Japonicins A and B from the flowers of Inula japonica.
Two new flavonols japonicins, A (1) and B (2), along with nine known flavonoids were isolated from an antidepressant fraction, which was separated from the 70% alcohol extract of the flowers of Inula japonica Thumb. The structures of compounds 1 and 2 were determined as 3,3',4',5,9,10-hexahydroxy-12-methylchroman[2,3-h]flavone and 8-(1-(3,4-dihydroxyphenyl)ethyl)-3,3',4',5,7-pentahydroxyflavone by the analyses of physical constants and spectral data. The special flavonoid structure having the substituent 1-phenylethyl at C-8 position was discovered for the first time.
Yu
N-J
NJ
Laboratory of Phytochemistry, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Zhao
Y-M
YM
Zhang
Y-Z
YZ
Li
Y-F
YF
D000928:Antidepressive Agents / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D035264:Flowers; D006801:Humans; D038143:Inula; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry
D000928:Antidepressive Agents; D005419:Flavonoids; D010936:Plant Extracts