title: Erysipelothrix rhusiopathiae neuraminidase and its role in pathogenicity.
abstract: The role of the enzyme neuraminidase in pathogenicity of the bacillus Erysipelothrix rhusiopathiae was studied. Different substances with low and high molecular weight were tested as inducers of E. rhusiopathiae neuraminidase biosynthesis. It was found that macromolecular complexes induce the secretion of the enzyme. K(M) values for different substrates showed that the affinity of the E. rhusiopathiae neuraminidase increases in parallel with the enlargement of the molecular weight of glycoproteins. Results from the rabbits skin test confirmed the role of E. rhusiopathiae neuraminidase as a factor of pathogenicity with spreading functions.
authors.affiliation: Bulgarian Academy of Sciences, Institute of Microbiology, Department of Microbial Biochemistry, 26 Acad. G. Bonchev str., 1113 Sofia, Bulgaria. abrashev@microbio.bas.bg
authors.forename: Ignat
authors.initials: I
authors.lastname: Abrashev
authors.forename: Petya
authors.initials: P
authors.lastname: Orozova
mesh_terms: D004790:Enzyme Induction; D004888:Erysipelothrix / Q000201:enzymology* / Q000472:pathogenicity*; D004889:Erysipelothrix Infections / Q000201:enzymology*; D007700:Kinetics; D009439:Neuraminidase / Q000378:metabolism*; D017192:Skin Diseases, Bacterial / Q000201:enzymology*
chemical_list: D009439:Neuraminidase