DNA replication: keep moving and don't mind the gap.
As the replication fork progresses, synthesis of the discontinuous lagging strand requires frequent priming and cycling of the lagging strand polymerase to the new primers. It appears that this mechanism also permits bypass of template lesions on both strands, leaving the damage behind in a single-strand gap and precluding fork stalling or collapse.
Langston
Lance D
LD
Howard Hughes Medical Institute, The Rockefeller University, New York City, New York 10021, USA.
O'Donnell
Mike
M
D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000502:physiology; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D009097:Multienzyme Complexes / Q000737:chemistry / Q000502:physiology; D000099272:Replisomes
D004259:DNA-Directed DNA Polymerase; D009097:Multienzyme Complexes; D000099272:Replisomes