Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma.
We report two cases of eccrine porocarcinoma (EPC), one of intrepidermal EPC (IEEPC) and one of intradermal invasive EPC (IDEPC) in an immunohistochemical study of cytokeratins (CK) using nine different anti-keratin antibodies against CK1, 7, 8, 10, 14, 16, 17, 18 and 19. IEEPC expressed terminal differentiated CK1 and CK10. In contrast, IDEPC expressed simple-epithelial keratins such as CK7, 8, 18 and 19. Keratin expression of IEEPC preserves the immunophenotypes of normal epidermis. IDEPC, however, expresses poorly differentiated keratin. These results suggest that the keratin profiles of EPC are correlated with the invasive degree and reflect the clinical prognosis of EPC.
Kurokawa
Ichiro
I
Department of Dermatology, Mie University Graduate School of Medicine, Mie 514-8507, Japan. kuroichi@clin.medic.mie-u.ac.jp
Urakawa
Yoshiko
Y
Senba
Yuko
Y
Kawabata
Eriko
E
Nishimura
Keisuke
K
Omoto
Youichi
Y
Tokime
Kazuya
K
Mizutani
Hitoshi
H
Tsubura
Airo
A
D018250:Acrospiroma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D004439:Eccrine Glands / Q000378:metabolism* / Q000473:pathology; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism*
D007633:Keratins