title: Role of C825T polymorphism of GNbeta3 gene in preeclampsia.
abstract: OBJECTIVE
  The main objective of the study was to understand the role of C825T polymorphism that generates a splice variant in the beta3 subunit of heterotrimeric G-protein in preeclampsia.
  
  
  RESULTS
  We analyzed genomic DNA of 151 women with preeclampsia (72 Caucasians and 79 African-Americans) and 198 women with normal delivery (102 Caucasians and 96 African-Americans) for C825T polymorphism of GNbeta3 gene. The T-allele frequency in Caucasian women with preeclampsia was 0.42 as compared to 0.25 in normal pregnant women (p = 0.0004) and in African-American women with preeclampsia was 0.82 as compared to 0.68 in normal pregnant women (p = 0.0028).
  
  
  CONCLUSIONS
  Results of these experiments show that the allele frequency of C825T polymorphism is significantly different in women with preeclampsia compared with women with normal delivery in Caucasian as well as African-American population.
authors.affiliation: Department of Pathology, New York Medical College, Valhalla, New York 10595, USA.
authors.forename: Xiangna
authors.initials: X
authors.lastname: Tang
authors.forename: Mallikarjunarao
authors.initials: M
authors.lastname: Guruju
authors.forename: Geetha P
authors.initials: GP
authors.lastname: Rajendran
authors.forename: Christy M
authors.initials: CM
authors.lastname: Isler
authors.forename: James N
authors.initials: JN
authors.lastname: Martin
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics; D016022:Case-Control Studies; D003596:Cytosine; D005260:Female; D005787:Gene Frequency; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D013941:Thymine; D044465:White People / Q000235:genetics
chemical_list: C454420:G-protein beta3 subunit; D003596:Cytosine; D020962:Heterotrimeric GTP-Binding Proteins; D013941:Thymine