title: MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women.
abstract: OBJECTIVE
  The aim of our study was to examine genetic variability in the gene encoding methylenetetrahydrofolate reductase (MTHFR) and individual susceptibility to the placental abruption or preeclampsia.
  
  
  METHODS
  362 women (133 with preeclampsia, 117 with placental abruption, and 112 healthy controls) were genotyped for C677T polymorphism in the MTHFR gene.
  
  
  RESULTS
  Similar genotype distributions were observed in the frequencies of C/C homozygotes (58.6%, 64.1%, and 57.1% for the three groups, respectively) and mutant homozygotes T/T (9.0%, 5.1% and 5.4%). No significant differences were detected in T allele frequencies (25.2%, 20.5%, and 24.1% for the three groups, respectively).
  
  
  CONCLUSIONS
  MTHFR C677T polymorphism does not have a major role in the development of preeclampsia or placental abruption in the Finnish population.
authors.affiliation: Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland.
authors.forename: Ester
authors.initials: E
authors.lastname: Jääskeläinen
authors.forename: Leea
authors.initials: L
authors.lastname: Keski-Nisula
authors.forename: Sari
authors.initials: S
authors.lastname: Toivonen
authors.forename: Eeva-Liisa
authors.initials: EL
authors.lastname: Romppanen
authors.forename: Seppo
authors.initials: S
authors.lastname: Helisalmi
authors.forename: Kari
authors.initials: K
authors.lastname: Punnonen
authors.forename: Seppo
authors.initials: S
authors.lastname: Heinonen
mesh_terms: D000037:Abruptio Placentae / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D003596:Cytosine; D005260:Female; D005387:Finland; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D013941:Thymine
chemical_list: D003596:Cytosine; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013941:Thymine