title: New derivatization reactions in pharmaceutical analysis.
abstract: The application of chemical reactions in conjunction with spectrometric and chromatographic methods is exemplified by the formation of 2-nitrophenylhydrazide derivatives for the spectrometric assay of carboxylic acids; silylation and trifluoroacetylation of drugs for gas chromatography; selective reduction of steroid ketones for their IR spectrometric identification; the use of epoxidation in discriminating between saturated and unsaturated steroids in gas chromatography; increasing the selectivity and sensitivity of the spectrometric and gas chromatographic determination of isomeric Delta4- and Delta5-3-ethylenedioxy steroids by treatment with hydrochloric acid; and the use of the same reagent in the difference spectrometric determination of 2,5-dimethyl-alpha-ethyl benzhydrol.
authors.affiliation: Chemical Works of Gedeon Richter Ltd, P.O. Box 27, H-1475 Budapest, Hungary.
authors.forename: S
authors.initials: S
authors.lastname: Görög
authors.forename: A
authors.initials: A
authors.lastname: Laukó
authors.forename: M
authors.initials: M
authors.lastname: Rényei
authors.forename: B
authors.initials: B
authors.lastname: Hegedüs