Specific anti-Toxoplasma gondii antibodies produced in inbred mice differring in their natural resistance to toxoplasmosis.
The laboratory diagnostics of T. gondii infections both in humans and animals relies mainly upon detection of specific antibodies. We studied the influence of the host genetic factors on the level and repertoire of antibodies produced in Toxoplasma infection employing as an experimental model two inbred mouse strains with different innate susceptibility to toxoplasmosis. Using polyvalent antigen preparations in ELISA and microagglutination we found no differences in the antibody levels in both strains. By comparison of the antibody profiles in immunoblot we determined mouse strain-specific and common toxoplasmosis markers.
Dytnerska
Katarzyna
K
Institute of Microbiology and Immunology, University of Lódź, Poland. kdytner@biol.uni.lodz.pl
Gatkowska
Justyna
J
Długońska
Henryka
H
D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology* / Q000302:isolation & purification; D000953:Antigens, Protozoan / Q000276:immunology / Q000302:isolation & purification; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease / Q000145:classification*; D007113:Immunity, Innate / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012698:Serologic Tests; D013045:Species Specificity; D014122:Toxoplasma / Q000302:isolation & purification; D014124:Toxoplasmosis, Animal / Q000235:genetics* / Q000276:immunology*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D015415:Biomarkers