title: Detection of salivary interleukin 2 and interleukin 6 in patients with burning mouth syndrome.
abstract: The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patients with BMS, age range 55-65, was tested for the presence of IL-6 and IL-2 by enzyme immunoassay. Control group consisted of 30 healthy participants, aged 55-65 years. Saliva IL-2 concentrations in BMS were significantly increased in patients compared to healthy subjects: mean 34.1 +/- 9.7 versus 7.3 +/- 3.0 pg/mL; P < .001. Patients with BMS had significantly higher concentrations of IL-6 compared to control: mean 30.8 +/- 5.6 versus 5.2 +/- 2.8 pg/mL; P < .001. In patients with BMS, IL-2 and IL-6 levels in saliva are elevated, correlating with the severity of illness.
authors.affiliation: School of Dentistry, Medical Faculty, University of Rijeka, 51000 Rijeka, Croatia.
authors.forename: Daria
authors.initials: D
authors.lastname: Simcić
authors.forename: Sonja
authors.initials: S
authors.lastname: Pezelj-Ribarić
authors.forename: Renata
authors.initials: R
authors.lastname: Grzić
authors.forename: Jelena
authors.initials: J
authors.lastname: Horvat
authors.forename: Gordana
authors.initials: G
authors.lastname: Brumini
authors.forename: Miranda
authors.initials: M
authors.lastname: Muhvić-Urek
mesh_terms: D000368:Aged; D002054:Burning Mouth Syndrome / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005786:Gene Expression Regulation; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000378:metabolism; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000378:metabolism
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D012471:Salivary Proteins and Peptides