title: Direct observation of surface-mediated thioacetyl deprotection: covalent tethering of a thiol-terminated porphyrin to the Ag(100) surface.
abstract: Covalent tethering of macromolecules such as porphyrins to metal surfaces underpins bottom-up fabrication of systems intended for a variety of applications. Thiol linkages are especially useful but often need protection during macromolecule synthesis. By means of scanning tunneling microscopy, we directly observe the spontaneous deprotection of an acetyl-protected thioporphyrin upon contact with a silver surface, without the intervention of any solution-mediated chemistry.
authors.affiliation: Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
authors.forename: Owain P H
authors.initials: OP
authors.lastname: Vaughan
authors.forename: Mark
authors.initials: M
authors.lastname: Turner
authors.forename: Federico J
authors.initials: FJ
authors.lastname: Williams
authors.forename: Andreas
authors.initials: A
authors.lastname: Hille
authors.forename: Jeremy K M
authors.initials: JK
authors.lastname: Sanders
authors.forename: Richard M
authors.initials: RM
authors.lastname: Lambert