Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation.
Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.
Keeney
S
S
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 97, New York, NY 10021, USA. s-keeney@ski.mskcc.org
Neale
M J
MJ
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D008540:Meiosis / Q000235:genetics; D011485:Protein Binding; D011995:Recombination, Genetic / Q000235:genetics*
D004247:DNA