Successful treatment of Candida parapsilosis (fluconazole-resistant) osteomyelitis with caspofungin in a HIV patient.
Treating Candida arthritis is challenging. We report a case of Candida parapsilosis arthritis successfully treated with caspofungin. We illustrate the likelihood of severe infections due fluconazole resistant C. parapsilosis after extensive fluconazole use and discuss the role of newer antifungal agents in the treatment of arthritis due to Candida spp.
Legout
L
L
Orthopaedic Surgery Service, University Hospital of Geneva, Switzerland. laurence.legout@hcuge.ch
Assal
M
M
Rohner
P
P
Lew
D
D
Bernard
L
L
Hoffmeyer
P
P
D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology / Q000821:virology; D000077336:Caspofungin; D004352:Drug Resistance, Microbial; D054714:Echinocandins; D015725:Fluconazole / Q000494:pharmacology*; D006678:HIV; D015658:HIV Infections / Q000382:microbiology*; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology / Q000821:virology; D010456:Peptides, Cyclic / Q000627:therapeutic use*
D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D015725:Fluconazole; D000077336:Caspofungin