Meiotic crossing-over: obligation and interference.
During meiosis, crossing-over--the exchange of genetic material between maternal and paternal chromosomes--is stringently controlled to restrict the number of crossovers per chromosome pair. In this issue of Cell, Martini et al., (2006) report that the reduction of crossover-initiating events does not result in fewer crossovers. These results have important implications for our understanding of crossover control.
Jones
Gareth H
GH
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK. g.h.jones@bham.ac.uk
Franklin
F Chris H
FC
D003434:Crossing Over, Genetic; D006706:Homeostasis; D008540:Meiosis; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology*