No gender difference in development of obliterative airway disease in rat tracheal allografts.
The aim of this study was to test whether donor and recipient gender influence the development of obliterative airway disease in an established rat model of human bronchiolitis obliterans. Rat tracheas were transplanted from male and female Brown-Norway donors into male and female Lewis recipients. Grafts were harvested at days 7, 14 and 21 for morphometric studies and molecular analysis by real-time PCR. At each time point, both epithelial injury and the extent of luminal occlusion of the tracheal allografts were similar between the groups. Furthermore, intragraft mRNA expression for transforming growth factor (TGF)-beta1, interleukin (IL)-2 and interferon (INF)-gamma did not differ between the groups. Our data suggest that gender has no impact on the development of obliterative airway disease in this transplant model.
Antus
Balazs
B
Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Pihenö Street 1, H-1529 Budapest, Hungary. antbal@net.sote.hu <antbal@net.sote.hu>
Fillinger
Janos
J
Sebe
Attila
A
Jeney
Csaba
C
Soltesz
Ibolya
I
Horvath
Ildiko
I
D000818:Animals; D001989:Bronchiolitis Obliterans / Q000473:pathology*; D016207:Cytokines / Q000235:genetics; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008297:Male; D009336:Necrosis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D012727:Sex Characteristics; D014132:Trachea / Q000637:transplantation*; D014184:Transplantation, Homologous / Q000379:methods*
D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger