title: Severe ventricular dysrhythmias and silent ischemia during infusion of the antimetabolite 5-fluorouracil and cis-platin.
abstract: The antimetabolite 5-fluorouracil is frequently used in the therapy of various malignancies. Cardiotoxicity has frequently been described during treatment, but there is no common agreement on the need to perform cardiovascular monitoring of patients during 5-fluorouracil administration. We report the case of a young patient with an head-neck cancer on whom a continuous electrocardiogram recording was performed, documenting serious ventricular dysrhythmias in the presence of myocardial ischemia during 5-fluorouracil and cis-platin infusion.
authors.affiliation: UO Cardiologia-ARC, Dip. Emergenza, AO SM degli Angeli, Italy. e.hrovatin@tin.it
authors.forename: Enzo
authors.initials: E
authors.lastname: Hrovatin
authors.forename: Elda
authors.initials: E
authors.lastname: Viel
authors.forename: Chiara
authors.initials: C
authors.lastname: Lestuzzi
authors.forename: Lucia
authors.initials: L
authors.lastname: Tartuferi
authors.forename: Fabio
authors.initials: F
authors.lastname: Zardo
authors.forename: Marco
authors.initials: M
authors.lastname: Brieda
authors.forename: Ermanno
authors.initials: E
authors.lastname: Dametto
authors.forename: Rita
authors.initials: R
authors.lastname: Piazza
authors.forename: Francesco
authors.initials: F
authors.lastname: Antonini-Canterin
authors.forename: Elda
authors.initials: E
authors.lastname: Vaccher
authors.forename: Nereo
authors.initials: N
authors.lastname: Meneguzzo
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Nicolosi
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced*
chemical_list: D000964:Antimetabolites, Antineoplastic; D002945:Cisplatin; D005472:Fluorouracil