[Immunovac VP-4 and GMDP increase the cytotoxic activity of mononuclear leukocytes and cytokine production in mice].
The cytotoxity of mononuclear leucocytes (ML) and the level of cytokines in mouse blood were estimated upon the administration of immunomodulators of microbial origin: a polycomponent vaccine Immunovak-VP-4 and GMDP (N-acetylglukozamin-N-acetylmuramoil-dipeptide, L-alanyl-D-izoglutaminyl). The immunomodulators reinforced the cytotoxic ML activity of murine spleens (p < 0.05) in comparison to that in control mice. The maximum increase in IL-6, IL-10, TNF-alpha, IFN-gamma in the blood was observed in 4 hours after administration of immunomodulators (p < 0.001).
Akhmatova
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D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016207:Cytokines / Q000276:immunology; D006020:Glycopeptides / Q000276:immunology / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects* / Q000276:immunology; D007155:Immunologic Factors / Q000276:immunology / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA
D001426:Bacterial Proteins; D016207:Cytokines; D006020:Glycopeptides; D007155:Immunologic Factors