title: Primary biomarkers in cerebral spinal fluid obtained from patients with influenza-associated encephalopathy analyzed by metabolomics.
abstract: In order to search for the specific biomarkers of patients with influenza-associated encephalopathy this article analyzed all metabolites in cerebrospinal fluid (CSF) by using metabolome analysis. In all metabolites, the peaks of two molecular weights, 246.0092 and 204.0611, were significantly higher than those in other diseases including influenza without convulsion (p < .05). The peak of a molecular weight 228.0247 in all of the patients except one was less than that in other patients. These results indicate that the new metabolites detected in CSF would be primary markers for the diagnosis of influenza-associated encephalopathy.
authors.affiliation: Department of Paediatrics, Tokyo Medical University, Japan. hisashi@tokyo-med.ac.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Manabu
authors.initials: M
authors.lastname: Oguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ioi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Amaha
authors.forename: Gaku
authors.initials: G
authors.lastname: Yamanaka
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Kashiwagi
authors.forename: Kouji
authors.initials: K
authors.lastname: Takekuma
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Akinori
authors.initials: A
authors.lastname: Hoshika
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid* / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000503:physiopathology; D008297:Male
chemical_list: D015415:Biomarkers