title: The role of Helicobacter pylori in urticaria and atopic dermatitis.
abstract: BACKGROUND
  Helicobacter pylori, a common cause of gastritis and peptic ulcer, has been associated with several extragastrointestinal diseases. Many studies have shown a positive relation between H. pylori infection and both chronic idiopathic urticaria and atopic dermatitis.
  
  
  METHODS
  The study included 20 patients diagnosed with chronic idiopathic urticaria and 20 with atopic dermatitis. A randomized sample of 20 healthy individuals was selected as a control group. H. pylori infection was assessed using the C-urea breath test, and anti-H. pylori IgG antibody titers were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  In the chronic idiopathic urticaria group, the urea breath test titer was positive in 75% of patients, and anti-IgG antibodies were also detected in 75% of patients. In the atopic dermatitis group, titer was positive in 70% and antibodies were detected in 65% of patients, while in the control group, the urea breath test titer was positive in 55% and antibodies were seen in 20% of patients. This difference was statistically highly significant (p < 0.001) in the case of anti-H. pylori antibodies in relation to chronic idiopathic urticaria and significant (p < 0.05) in the case of atopic dermatitis.
  
  
  CONCLUSIONS
  These results provide some evidence of a relationship between H. pylori infection and both chronic idiopathic urticaria and atopic dermatitis. Treatment of infection demonstrated by reduction in C-urea breath test and anti-H. pylori antibody titers resulted in partial improvement of clinical symptoms in patients with atopic dermatitis.
authors.affiliation: Faculty of Medicine and Health Sciences, Dermatology Department, United Arab Emirates University and Al Ain Hospital, Al Ain, United Arab Emirate. galadari@email.com
authors.forename: Ibrahim H
authors.initials: IH
authors.lastname: Galadari
authors.forename: Mohamed Omar
authors.initials: MO
authors.lastname: Sheriff
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D001944:Breath Tests; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000209:etiology*; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D014508:Urea / Q000032:analysis; D014581:Urticaria / Q000209:etiology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D014508:Urea