title: Small molecules in an RNAi world.
abstract: In this Opinion, we compare and contrast small molecules and RNAi. We discuss the advantages and disadvantages of both technologies focusing on timing, specificity, dose and therapeutic use.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. ulrike_eggert@hms.harvard.edu
authors.forename: Ulrike S
authors.initials: US
authors.lastname: Eggert
authors.forename: Christine M
authors.initials: CM
authors.lastname: Field
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Mitchison
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008954:Models, Biological; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D034741:RNA, Small Interfering