title: Quantitative determination of polymorphic forms in a formulation matrix using the near infra-red reflectance analysis technique.
abstract: An analytical method based upon near infra-red reflectance measurements on solid samples is described for the determination of the polymorphic transformation of an active ingredient in a solid dosage form matrix. Calculations were performed using multiple linear regression techniques. The method was applied to mixtures of two polymorphic forms of a new chemical entity in a formulation matrix and gave recoveries close to the expected values with an acceptable reproducibility.
authors.affiliation: Searle Recherche et Développement, Parc de Sophia Antipolis, 06561 Valbonne Cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Gimet
authors.forename: A T
authors.initials: AT
authors.lastname: Luong