Immune reconstitution syndrome in a child with TB and HIV.
Immune reconstitution syndrome (IRS) is the transient worsening or appearance of new signs, symptoms or radiological manifestation of an opportunistic infection occurring after the initiation of Highly active antiretroviral therapy (HAART) and is not due to treatment failure or new infection. We describe a case of a HIV infected child with tubercular (mediastinal) lymphadenitis with worsening of clinical and radiological features on starting HAART.
Narendran
G
G
Tuberculosis Research Centre, Chetput, Chennai, India.
Swaminathan
Soumya
S
Sathish
S
S
Rajasekaran
S
S
D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D002648:Child; D005938:Glucocorticoids / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D014388:Tuberculosis, Lymph Node / Q000150:complications / Q000188:drug therapy
D019380:Anti-HIV Agents; D000995:Antitubercular Agents; D005938:Glucocorticoids; D011239:Prednisolone