[Plasmacytoma with multiple hypervascular lesions revealed by angiography in a patient with multiple myeloma].
A 68-year-old woman suffering from a left iliac tumor and severe back pain was admitted to another hospital in May 1999. The bone X-ray, CT scan and MRI demonstrated a 7 cm x 5 cm left iliac tumor with osteolysis and she was transferred to our hospital. Angiography demonstrated multiple hypervascular lesions in the left ilium, lumbar vertebrae, left ischium, left pubis and left rib. The tumor was resected and diagnosed as a plasmacytoma. Immunoelectrophoresis did not show any M-protein in the serum and urine, but the patient was diagnosed as having a non-secretory or low producing multiple myeloma because of the presence of 42.8% of abnormal plasma cells in the bone marrow aspirate. Her symptoms improved following 3 courses of MCNU-VMP therapy and the bone marrow plasma cells decreased to less than 5%. She was discharged and treated as an outpatient but relapsed and died of chemotherapy-resistant myeloma. We report this case because macro-angiogenesis in a multiple myeloma demonstrated by angiography is rare and interesting.
Handa
Hiroshi
H
School of Health Science, Faculty of Medicine, Gunma University.
Irisawa
Hiroyuki
H
Komatsumoto
Satoru
S
Matsushima
Takafumi
T
Tsukamoto
Norifumi
N
Nojima
Yoshihisa
Y
Murakami
Hirokazu
H
D000368:Aged; D000792:Angiography; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001842:Bone and Bones / Q000098:blood supply / Q000000981:diagnostic imaging; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D009101:Multiple Myeloma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D010954:Plasmacytoma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014751:Vindesine / Q000008:administration & dosage
D009607:Nitrosourea Compounds; D011239:Prednisolone; D008558:Melphalan; D014751:Vindesine; D011241:Prednisone