Antiviral acyclic nucleoside phosphonates structure activity studies.
This review concerns acyclic nucleoside phosphonates (ANP) and describes the concept of the design of isopolar and isosteric nucleotide analogues resistant towards degradation by enzymes in vivo. It describes the development of research which led to the discovery of several structurally related potent antivirals and ultimately resulted in the development of drugs directed against HIV, HBV and DNA-virus infections in general, namely adefovir, cidofovir and tenofovir. In addition to these "classical compounds" the review describes the present development in the field of ANP, the "open-ring ANP" and discusses the present achievements, concept of prodrug design and application.
Holý
Antonín
A
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Centre for Novel Antivirals and Antineoplastics, 166 10 Praha 6, Czech Republic. holy@uochb.cas.cz
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004266:DNA Virus Infections / Q000188:drug therapy / Q000821:virology; D004267:DNA Viruses / Q000187:drug effects*; D006801:Humans; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D009705:Nucleosides; D063065:Organophosphonates