Coenzyme Q10 is increased in placenta and cord blood during preeclampsia.
Preeclampsia is a common (approximately 7% of all pregnancies) disorder of pregnancy in which the normal hemodynamic response to pregnancy is compromised. Despite many years of intensive research, the pathogenesis of preeclampsia is still not fully understood. The objective of the present study was to investigate the levels of coenzyme Q(10) (CoQ(10)) in placental tissue compared to maternal and umbilical cord levels both during normal pregnancy and in those complicated with preeclampsia. Pregnant women (n = 30) and women with preeclampsia (n = 30) were included. Maternal, newborn cord blood levels and placental content of coenzyme Q(10) were measured by high performance liquid chromatography (HPLC). Plasma coenzyme Q(10) levels were significantly higher in normal pregnant women than in women with preeclampsia. CoQ(10) content in placenta from women with preeclampsia (mean 0.28 SEM 0.11 nmol/mg protein) was significantly higher compared to normal pregnancy (mean 0.09 SEM 0.01 nmol/mg protein; p = 0.05). Levels of CoQ(10) in cord blood from normal pregnant women (mean 0.30 SEM 0.05 micromol/l) were significantly lower than in preeclamptic women (mean 4.03 SEM 2.38 micromol/l). In conclusion, these data indicate a possible involvement of CoQ(10) in preeclampsia that might bear deep physiopathological significance and deserve to be further elucidated.
Teran
Enrique
E
Experimental Pharmacology and Cellular Metabolism Unit, Biomedical Center, Central University of Ecuador, Quito. eteran@cbm.uce.edu.ec
Vivero
Sandra
S
Racines-Orbe
Marcia
M
Castellanos
Alberto
A
Chuncha
Galo
G
Enriquez
Galo
G
Moya
Walter
W
D000293:Adolescent; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003067:Coenzymes; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D010920:Placenta / Q000737:chemistry*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10