title: [Laboratory evaluation of the severity of intoxication syndrome in children with bacterial infections].
abstract: For the laboratory evaluation of the severity of intoxication syndrome, the spectral characteristics of low and median molecular weight substances (LMMWS) were studied in the plasma and red blood cells of 129 children with bacterial infections, among whom there were 76 children with acute intestinal infections (Flexner's dysentery, Sonne dysentery, and salmonellosis) and 53 children with bacterial purulent meningitis of hemophilic and meningococcal etiology. In the acute period, all the examinees were found to have considerable qualitative and quantitative distinctions of blood spectrograms from the normal values. There was an association of the spectral characteristics of blood LMMWS with the nosological entity, etiology and stage of disease, and the severity of intoxication syndrome. The maximum distinctions from the normal values were detected in children with bacterial meningitis running with complicating the course of acute intestinal infection. There was an increase in the blood levels of LMMWS with the concomitant intercurrent diseases occurring, as compared with the smooth uncomplicated course of disease. The studies of the natural history of disease have indicated a gradual normalization of blood spectrograms; however, in bacterial meningitis, insignificant deviations preserved at the stage of convalescence. The spectral characteristics of plasma and red blood cell LMMWS are proposed to use for the objective appraisal of the severity of intoxication syndrome and the reserve detoxification capacities of blood in children with bacterial infections.
authors.forename: L A
authors.initials: LA
authors.lastname: Alekseeva
authors.forename: T V
authors.initials: TV
authors.lastname: Bessonova
authors.forename: O V
authors.initials: OV
authors.lastname: Tikhomirova
authors.forename: A A
authors.initials: AA
authors.lastname: Vil'nits
authors.forename: O I
authors.initials: OI
authors.lastname: Nyrkova
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000097:blood* / Q000209:etiology / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D016920:Meningitis, Bacterial / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D008970:Molecular Weight; D012720:Severity of Illness Index; D013057:Spectrum Analysis
chemical_list: D015415:Biomarkers