title: Immunoglobulin A nephropathy complicating ulcerative colitis.
abstract: Ulcerative colitis is rarely associated with immunoglobulin A nephropathy (IgAN). The development of IgA nephropathy complicates further the clinical course of patients with ulcerative colitis. A 72-year old man with a 30-year history of ulcerative colitis requiring colectomy and modest renal insufficiency secondary to complications of nephrolithiasis and renal artery stenosis developed glomerular hematuria, proteinuria and progressive renal failure. Percutaneous kidney biopsy revealed IgAN with extensive glomerular and interstitial sclerotic changes. After resection of a chronically infected ileo-rectal pouch, renal function improved, while hematuria and proteinuria gradually disappeared without specific treatment of the IgAN. The manifestations of IgAN complicating ulcerative colitis can be improved with effective treatment of the bowel disease even when there are extensive sclerotic changes in the kidneys.
authors.affiliation: Renal Section, New Mexico Veterans Affairs Health Care System (VAHCS), Albuquerque, New Mexico, USA.
authors.forename: Aideloje
authors.initials: A
authors.lastname: Onime
authors.forename: Emmanuel I
authors.initials: EI
authors.lastname: Agaba
authors.forename: Yijuan
authors.initials: Y
authors.lastname: Sun
authors.forename: Robert B
authors.initials: RB
authors.lastname: Parsons
authors.forename: Karen S
authors.initials: KS
authors.lastname: Servilla
authors.forename: Larry W
authors.initials: LW
authors.lastname: Massie
authors.forename: Antonios H
authors.initials: AH
authors.lastname: Tzamaloukas
mesh_terms: D000368:Aged; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000601:surgery; D005922:Glomerulonephritis, IGA / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006417:Hematuria; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000601:surgery; D008297:Male; D011507:Proteinuria; D051437:Renal Insufficiency / Q000209:etiology; D012598:Sclerosis; D016896:Treatment Outcome