title: [STI571 for gastrointestinal stromal tumors].
abstract: Since the effectiveness of STI571 for GIST was reported, therapy for GIST has changed markedly, and the disease has attracted attention. We have treated 19 patients with GIST since 2000 by 19 resections (local resection in 14 patients, total gastrectomy in 2 patients, distal gastrectomy in 2 patients, and hepatectomy in 1 patient), and administered STI571 to 5 patients with unresectable or recurrent GIST. Of these 5 patients, 2, 1, 1, and 1 had PR, SD, PD, and inevaluable disease, respectively, with a response rate of 50%. The disease was controllable in 80% of the patients. All patients had palpebral and crural edema as side effects, which were not severe, suggesting the safety of the drug. It is important to tailor therapy (STI571 or surgery) to the patient.
authors.affiliation: Department of Surgery, Matsushita Memorial Hospital.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Akinori
authors.initials: A
authors.lastname: Noguchi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takeshita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Tadao
authors.initials: T
authors.lastname: Ito
authors.forename: Naoki
authors.initials: N
authors.lastname: Tani
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suganuma
authors.forename: Masahide
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Shinji
authors.initials: S
authors.lastname: Okano
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yamane
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate