title: Protective effect of lutein on ischemia-reperfusion injury in rat small intestine.
abstract: Lutein is a carotenoid and it has antioxidant effects. Lutein may have a protective effect on ischemia reperfusion (I/R) injury induced by free radical species. However, little is known about the protective effect of lutein on I/R injury in vivo. The present study was undertaken to clarify the protective effects of lutein on I/R injuries in the rat small intestine. Administration of lutein before intestinal I/R attenuated the damage to villi and deciduation of enterocytes and suppressed the increase in lipid peroxide.
authors.affiliation: Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan.
authors.forename: Wakako
authors.initials: W
authors.lastname: Ogura
authors.forename: Shirou
authors.initials: S
authors.lastname: Itagaki
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kurokawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Noda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirano
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizuno
authors.forename: Ken
authors.initials: K
authors.lastname: Iseki
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005609:Free Radicals; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology; D014975:Lutein / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D014975:Lutein