title: Cross-talk between APC/C and CBP/p300.
abstract: APC/C complex has been known to regulate cell cycle progression via its ubiquitin E3 ligase activity that targets a number of cell cycle regulators. In a recent report, it is shown that APC/C interacts with transcription co-activators, CBP and p300, via its APC5 and APC7 subunits. The authors further demonstrate the functional significance of APC/C-CBP/p300 interaction in regulating both transcription and cell cycle progression. These findings have profound implications in unveiling additional functions and regulatory mechanisms of these two seemingly independent molecular modulators.
authors.affiliation: Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6046, USA. jiangliu@vet.upenn.edu
authors.forename: Jianghuai
authors.initials: J
authors.lastname: Liu
authors.forename: Serge Y
authors.initials: SY
authors.lastname: Fuchs
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D064193:Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome; D064195:Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome; D002453:Cell Cycle / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002472:Cell Transformation, Viral / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D014158:Transcription, Genetic; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*; D050880:p300-CBP Transcription Factors / Q000378:metabolism*
chemical_list: C577375:ANAPC5 protein, human; C577399:ANAPC7 protein, human; D064193:Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome; D064195:Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome; D050880:p300-CBP Transcription Factors; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome