Interleukin-1 gene complex in schizophrenia: an association study.
The aim of this study is to investigate the association between three polymorphisms of the interleukin-1 (IL-1) gene complex and schizophrenia. We genotyped 228 outpatients with schizophrenia (DSM-IV criteria) and 419 unrelated healthy controls. The following polymorphisms were analyzed: IL-1alpha -889 C/T, IL-1beta +3953 C/T, and IL-1RA (86 bp)n. No significant differences in genotype or in allelic distribution of the Il-1alpha, IL-1beta, and IL-1RA polymorphisms were found. Estimated haplotype frequencies were similar in both groups. Our data do not suggest that genetically determined changes in the IL-1 gene complex confer increased susceptibility for schizophrenia.
Saiz
Pilar A
PA
Department of Psychiatry, School of Medicine, University of Oviedo, Oviedo, Spain. frank@uniovi.es
Garcia-Portilla
Maria P
MP
Arango
Celso
C
Morales
Blanca
B
Martinez-Barrondo
Sara
S
Alvarez
Victoria
V
Coto
Eliecer
E
Fernandez
Juan
J
Bousono
Manuel
M
Bobes
Julio
J
D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D007375:Interleukin-1