title: [Steroid-aggravated rosacea: successful therapy with pimecrolimus].
abstract: Steroid-induced erythema in rosacea is a therapeutic challenge because of its tendency to rebound and the local characteristics of the facial skin. We describe 3 cases of steroid-induced rosacea with the typical history of steroid abuse with tachyphylaxis. Steroids with increasing potency had to be used with increasing frequency in the course of treatment in order to achieve a response. Acute exacerbations followed any attempt at withdrawal. The steroid treatment was discontinued and therapy with pimecrolimus cream 1% twice daily initiated. This brought rapid and marked improvement within a few days. The cases show that the calcineurin antagonist pimecrolimus offers an effective and well-tolerated therapy option in the acute therapy of steroid-aggravated facial dermatoses.
authors.affiliation: Universitätsklinik und Poliklinik für Dermatologie und Venerologie der Martin-Luther-Universität Halle-Wittenberg, Ernst-Kromayer-Strasse 5, 06097 Halle (Saale). Nuschin.Meykadeh@medizin.uni-halle.de
authors.forename: N
authors.initials: N
authors.lastname: Meykadeh
authors.forename: F
authors.initials: F
authors.lastname: Meiss
authors.forename: W C
authors.initials: WC
authors.lastname: Marsch
authors.forename: M
authors.initials: M
authors.lastname: Fischer
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D012393:Rosacea / Q000139:chemically induced* / Q000188:drug therapy*; D013256:Steroids / Q000009:adverse effects* / Q000627:therapeutic use; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003879:Dermatologic Agents; D013256:Steroids; C117268:pimecrolimus; D016559:Tacrolimus