Modulatory effects of diallyl sulfide against testosterone- induced oxidative stress in Swiss albino mice.
OBJECTIVE
To investigate the protective effect of diallyl sulfide (DAS), a constituent of garlic, against testosterone-induced oxidative stress in male Swiss albino mice.


METHODS
The animals were given low (250 mg/animal) and high dose (500 mg/animal) of DAS in corn oil for 7 days along with testosterone (5 mg/kg body weight, i.p.). At the end of the study period, the prostate and the liver were dissected to determine various antioxidant enzyme levels (catalase, superoxide dismutase, glutathione reductase, glutathione-s-transferase) and lipid peroxidation.


RESULTS
In testosterone treated mice, depleted antioxidant enzyme level was accompanied with enhancement in lipid peroxidation in prostate and liver. DAS significantly restored the testosterone-induced antioxidant enzymes and lipid peroxidation in the both organs. These changes appear to be mediated by the antioxidant-enhancing effects of DAS.


CONCLUSIONS
The results of the present study suggest that DAS is effective in exerting antioxidant effects by inhibiting testosterone-induced oxidative stress and might be helpful in preventing prostate cancer.
Prasad
Sahdeo
S
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, PO Box 80; M.G. Marg, Lucknow 226001, India.
Kalra
Neetu
N
Shukla
Yogeshwer
Y
D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D013440:Sulfides / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013739:Testosterone / Q000037:antagonists & inhibitors*
D000498:Allyl Compounds; D013440:Sulfides; D013739:Testosterone; C038491:allyl sulfide; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase