title: Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination.
abstract: Chronic opioid administration modulates lymphocytes' functional capabilities increasing susceptibility to infectious diseases. Bacille-Calmette-Guérin (BCG) vaccination initiates a non-specific and specific cell-mediated immunity orchestrated by T lymphocytes including gammadelta T lymphocytes. gammadelta T lymphocytes increase in natural killer and antigen-directed cytolytic response following BCG vaccination. The objective of this study was to determine morphine effects on gammadelta T lymphocytes' cytolytic activity. Pigs were chronically administered morphine and subsequently vaccinated with Mycobacterium bovis BCG. By administering morphine prior to BCG vaccination, natural killer response was significantly suppressed (p=.034). Furthermore, innate cytolytic response against M. bovis-infected monocytes (p=.002) as well as antigen specific cytolytic functions (p=.04) were significantly altered due to morphine administration. It was concluded that administering morphine prior to BCG vaccination significantly altered gammadelta T lymphocyte cytolytic responses.
authors.affiliation: University of Minnesota, Veterinary Population Medicine, College of Veterinary Medicine, 1365 Gortner Ave., St. Paul, MN 55108, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Olin
authors.forename: Keumhwa
authors.initials: K
authors.lastname: Choi
authors.forename: Jinhee
authors.initials: J
authors.lastname: Lee
authors.forename: Phillip K
authors.initials: PK
authors.lastname: Peterson
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Molitor
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular / Q000187:drug effects* / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D008297:Male; D009020:Morphine / Q000276:immunology / Q000494:pharmacology*; D009163:Mycobacterium bovis / Q000276:immunology; D009294:Narcotics / Q000276:immunology / Q000494:pharmacology*; D034421:Sus scrofa; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology
chemical_list: D001500:BCG Vaccine; D009294:Narcotics; D009020:Morphine