title: A case of epidermodysplasia verruciformis associated with squamous cell carcinoma and Bowen's disease: a therapeutic challenge.
abstract: Epidermodysplasia verruciformis (EV) is a very rare and chronic disease characterized by a susceptibility to cutaneous infections by a group of phylogenetically related human papillomavirus (HPV) types. We present here a 52-year-old man previously diagnosed and treated as squamous cell carcinoma but also found to have epidermodysplasia verruciformis lesions in association with Bowen's disease. The patient was effectively treated with a combination of interferon therapy (6 million units, twice a week) and topical imiquimod for Bowen's disease (five times a week). We conclude that topical imiquimod is very effective in the treatment of Bowen's disease and may be combined with systemic interferon therapy in rare cases with multiple vivid presentations of HPV infections.
authors.affiliation: Departments of DermatologyPathology, Uludag University Medical Faculty, Bursa, Turkey. bbemel@uludag.edu.tr
authors.forename: Emel Bulbul
authors.initials: EB
authors.lastname: Baskan
authors.forename: Sukran
authors.initials: S
authors.lastname: Tunali
authors.forename: Saduman Balaban
authors.initials: SB
authors.lastname: Adim
authors.forename: Aysegul
authors.initials: A
authors.lastname: Turan
authors.forename: Semra
authors.initials: S
authors.lastname: Toker
mesh_terms: D000279:Administration, Cutaneous; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001913:Bowen's Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004819:Epidermodysplasia Verruciformis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D000077271:Imiquimod; D007372:Interferons / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012535:Scalp / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D007372:Interferons; D000077271:Imiquimod