title: Chiral ytterbium complex-catalyzed direct asymmetric aldol-Tishchenko reaction: synthesis of anti-1,3-diols.
abstract: The asymmetric aldol-Tishchenko reaction of aromatic aldehydes with aliphatic and aromatic ketones has been developed as an efficient strategy for the synthesis of anti-1,3-diols in good yield with high diastereocontrol and good levels of enantioselectivity. This domino-type reaction is catalyzed by a chiral ytterbium complex that promotes both the aldol reaction through enolization of the carbonyl compound and the Evans-Tishchenko reduction of the aldol intermediate. The stereochemistry of the resulting diols is also investigated and finally proved by using CD techniques.
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland. mlynar@icho.edu.pl
authors.forename: Jacek
authors.initials: J
authors.lastname: Mlynarski
authors.forename: Bartosz
authors.initials: B
authors.lastname: Rakiel
authors.forename: Maciej
authors.initials: M
authors.lastname: Stodulski
authors.forename: Agata
authors.initials: A
authors.lastname: Suszczyńska
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Frelek