Radiotherapy in the multimodal treatment of extrarenal extracranial malignant rhabdoid tumors.
Extrarenal extracranial malignant rhabdoid tumors (MRT) are extremely rare and typically lethal. No consensus exists on an optimal treatment approach, and, in particular, the role of radiation therapy (RT) is poorly defined. We report on three children who underwent multimodality treatment including surgery, chemotherapy (CMT), and RT. Two of these patients are alive and without evidence of disease 6(1/2) and 7 years after diagnosis and one has expired. Our limited experience suggests that RT in the setting of CMT and surgery has the potential to prolong survival with acceptable toxicity, but outcomes are inconsistent and further study is necessary.
Puri
Dev R
DR
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Meyers
Paul A
PA
Kraus
Dennis H
DH
Laquaglia
Michael P
MP
Wexler
Leonard H
LH
Wolden
Suzanne L
SL
D002648:Child; D003131:Combined Modality Therapy; D004200:Diseases in Twins; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D006801:Humans; D007223:Infant; D018335:Rhabdoid Tumor / Q000235:genetics / Q000532:radiotherapy*