Temporal changes in the incidence of epilepsy in Finland: nationwide study.
OBJECTIVE
To examine possible changes over time in the incidence of epilepsy in different age groups.


METHODS
Based on the nationwide full-refundable antiepileptic drug register and population register, incidence of newly diagnosed epilepsy was measured by granted full-refundable antiepileptic drugs for epilepsy.


RESULTS
The incidence was throughout all age groups higher in men than in women. The incidence in the total population had significantly declined in 1986-2002, from 71.6/100,000 to 52.9/100,000. The incidence significantly decreased in children (0.77; 0.71-0.84, p<0.0001) and adults (0.83; 0.77-0.89, p<0.0001) but increased in the elderly (1.18; 1.10-1.26, p<0.0001). The increased incidence in the elderly over the time period was primarily seen in women.


CONCLUSIONS
The incidence of epilepsy has significantly declined in both children and adults with a concurrent increase in the incidence among the elderly. Further studies are needed to elucidate the precise cause of these temporal changes.
Sillanpää
Matti
M
Department of Public Health, University of Turku, Turku, Finland. matti.sillanpaa@utu.fi
Kälviäinen
Reetta
R
Klaukka
Timo
T
Helenius
Hans
H
Shinnar
Shlomo
S
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D011159:Population Surveillance; D017678:Sex Distribution
D000927:Anticonvulsants