[Preparation of gelatin nanogel modified with fluoride anion and its ultrasonic triggered release characteristics].
OBJECTIVE
To investigate the preparation, shape and ultrasound triggered release characteristics of gelatin nanogel modified with fluoride anion.


METHODS
Adriamycin gelatin nanogel modified with fluoride anion (ADM-FMNG) was prepared by co-precipitation with fluoride anion. The content and encapsulation rate of adriamycin were measured by HPLC method. The size and shape of ADM-FMNG were determined by electron microscope. The size and distribution of ADM-FDNG before and after sonication were measured by laser size analysis device.


RESULTS
The average diameter of ADM-FMNG was (46 +/- 12) nm. Adriamycin encapsulated rate and loading were 87.2% and 0.091 g x L(-1), respectively. 48.5% of adriamycin was released within 50 h while in vitro at 37 degrees C. Under the action of ultrasound that has the frequency of 20 kHz, 0.4 W x cm(-2) of power density and 7-8 min duration, 51. 5% of adriamycin in ADM-FMNG was released that was significantly higher than control group, the size of ADM-FMNG was changed from (46 +/- 12) nm to (1,212 +/- 35) nm and restored after ultrasound stopped for 3-4 min.


CONCLUSIONS
ADM-FDNG system has the sensitive ultrasound triggered release characteristics.
Wu
Dao-cheng
DC
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, China. wudaocheng@mail.xjtu.edu.cn
Wan
Ming-xi
MX
Wu
Hong
H
D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005459:Fluorides; D005780:Gelatin; D000080385:Nanogels; D053758:Nanoparticles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D014465:Ultrasonics
D004337:Drug Carriers; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D004317:Doxorubicin; D005780:Gelatin; D011094:Polyethyleneimine; D005459:Fluorides