title: [Screening of new derivatives of arylheteroalkanecarboxylic acid on the immune system].
abstract: The screening of 13 original compounds from the group of derivatives of arylheteroalkanecarboxylic acid on immunity were performed. The compounds exhibit strong myelostimulating/myelosuppressive property, increased or decreased influence on the: PFC (IgM and IgG), DTH at the sheep erythrocytes in CBF1 in vivo. In contrast, in vitro the compounds had no effect or inhibited the spontaneous, ConA or PWM induced proliferation of the splenocytes from normal mice. The problems of the universal methods of the screening of immunoactive properties of compounds are discussed.
authors.forename: O P
authors.initials: OP
authors.lastname: Kolesnikova
authors.forename: O T
authors.initials: OT
authors.lastname: Kudaeva
authors.forename: T G
authors.initials: TG
authors.lastname: Sukhenko
authors.forename: A P
authors.initials: AP
authors.lastname: Lykov
authors.forename: K V
authors.initials: KV
authors.lastname: Gaĭdul'
authors.forename: V L
authors.initials: VL
authors.lastname: Limonov
authors.forename: A N
authors.initials: AN
authors.lastname: Mirskova
authors.forename: G G
authors.initials: GG
authors.lastname: Lavskovskaia
authors.forename: M G
authors.initials: MG
authors.lastname: Voronkov
authors.forename: V A
authors.initials: VA
authors.lastname: Kozlov
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D002264:Carboxylic Acids / Q000276:immunology / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D051379:Mice; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D002264:Carboxylic Acids; D007074:Immunoglobulin G; D007075:Immunoglobulin M