[Thrombotic microangiopathies in the intensive care unit].
OBJECTIVE
To analyze the clinico-biological manifestations, identify the causes and evaluate the outcome of patients with severe thrombotic microangiopathies admitted in a Tunisian intensive care unit.


METHODS
Retrospective study over a period of 10 years (1995-2004) in an intensive care unit.


RESULTS
Were included in this study 9 cases with a mean age of 29.2+/-9 years (range 15-44 years). Fever was observed in 5 patients, neurological impairment in 5 and digestive manifestations in 6. Haemolytic anaemia, thrombocytopenia and acute renal failure were observed in 100% of the cases. In our study, the aetiologies of thrombotic microangiopathies were: complicated pregnancy in 6 cases, systemic lupus erythematosus in 1 case. In contrast, no aetiology was found in 2 patients. Plasma exchange was performed in 5 patients, while 4 patients received only plasma infusion. After an average stay of 18+/-12.5 days, evolution was marked by the death 3 patients.


CONCLUSIONS
The incidence of severe thrombotic microangiopathies is rare in Tunisian ICU. The clinical manifestations are not specific. Despite the improvement in the outcome by exogenous plasma supply, thrombotic microangiopathies with severe organ dysfunctions leading to hospitalization in the intensive care unit are associated with a high mortality rate.
Bahloul
M
M
ICU, Centre Hospitalier H.-Bourguiba, route El-Ain, Km 0,5, 3029 Sfax, Tunisie. bahloulmab@yahoo.fr
Ben Hamida
C
C
Dammak
H
H
Chaari
L
L
Kallel
H
H
Chelly
H
H
Rekik
N
N
Bouaziz
M
M
D058186:Acute Kidney Injury / Q000150:complications; D000293:Adolescent; D000328:Adult; D000462:Algeria / Q000453:epidemiology; D000743:Anemia, Hemolytic / Q000150:complications / Q000175:diagnosis; D016887:Cardiopulmonary Resuscitation; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007362:Intensive Care Units; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology / Q000503:physiopathology; D016491:Peripheral Vascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D010951:Plasma Exchange; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D012189:Retrospective Studies; D016896:Treatment Outcome