Derivatization reactions in the gas-liquid chromatographic analysis of drugs in biological fluids.
Alkylation, acylation, silylation and other derivatization reactions applied to the gas chromatographic analysis of drugs in biological matrices are reviewed. Reaction conditions are discussed in relation to reaction mechanisms. Detector-oriented labelling of drugs, and derivatization with chiral reagents for the separation of enantiomers are surveyed. Data on the sample clean-up, derivatization and GLC analysis of more than 300 drugs and related compounds are listed.
Hulshoff
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Department of Analytical Pharmacy, University of Utrecht, Pharmaceutical Laboratory, Catherijnesingel 60, 3511 GH Utrecht, The Netherlands.
Lingeman
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