title: Application of genetic approaches to ocular disease.
abstract: The human eye is a complex organ whose development requires extraordinary coordination of developmental processes. Multiple genes responsible for the proper development and maintenance of the vertebrate eye have been identified and shown to be involved in a variety of debilitating ocular conditions. Genetic diseases involving the eye represent a leading cause of blindness in children and adults. This article summarizes current genetic approaches and their application to studies of ocular disease.
authors.affiliation: Medical College of Wisconsin, 925 North 87th Street, Milwaukee, WI 53226, USA. mruttum@mcw.edu
authors.forename: Mark S
authors.initials: MS
authors.lastname: Ruttum
authors.forename: Linda M
authors.initials: LM
authors.lastname: Reis
authors.forename: Elena V
authors.initials: EV
authors.lastname: Semina
mesh_terms: D000818:Animals; D002648:Child; D005128:Eye Diseases / Q000145:classification / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans