[Function of PAT family proteins in the lipid metabolism].
Triglycerides are stored in intracellular lipid droplets in mammalian cells. Current evidences suggest that the intracellular lipid droplets are active participants in a variety of metabolic processes, and thus are considered as functional organelles in cells. The lipid droplet is composed of a triglyceride core surrounded by a phospholipid monolayer in which several proteins are embedded. Four of these proteins belong to a family of structurally related PAT protein, which includes perilipin, ADRP, TIP47 and S3-12. In this review, we summarize the functions of these proteins in the modulation of lipolysis and lipid droplets formation.
Liu
Mei-Fang
MF
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China.
Xu
Guo-Heng
GH
D017667:Adipocytes / Q000000981:diagnostic imaging / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins; D004268:DNA-Binding Proteins / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D000070778:Perilipin-1; D000070780:Perilipin-2; D000070796:Perilipin-3; D000071229:Perilipin-4; D010750:Phosphoproteins / Q000502:physiology*; D011257:Pregnancy Proteins / Q000502:physiology*; D014280:Triglycerides / Q000378:metabolism*; D014463:Ultrasonography; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C000602982:PLIN2 protein, human; C038196:PLIN3 protein, human; D000070778:Perilipin-1; D000070780:Perilipin-2; D000070796:Perilipin-3; D000071229:Perilipin-4; D010750:Phosphoproteins; C000602983:Plin2 protein, mouse; C487119:Plin4 protein, mouse; D011257:Pregnancy Proteins; D014280:Triglycerides; D033921:Vesicular Transport Proteins