Regular physical activity increases glutathione peroxidase activity in adolescents with Down syndrome.
OBJECTIVE
The present study was designed to determine the influence of a 12-week exercise program on the activity of erythrocyte glutathione peroxidase (GPX) in adolescents with Down syndrome.


METHODS
An interventional study with before-after comparison.


METHODS
Sport Medicine School, University of Cadiz (Andalusia, Spain).


METHODS
Thirty-one male adolescents (16.3+/-1.1) with Down syndrome. None of them suffered acute medical problems at that moment and had not taken part in any physical activity program in the last 6 months.


METHODS
A 12-week training program with 3 days per week, consisting of warm up (15 min) followed by a main part (20 to 35 min) at a work intensity of 60% to 75% of peak heart rate (HRmax=194.5-[0.56xage]) and by a cool-down period (10 min).


METHODS
Erythrocyte activity of GPX.


RESULTS
Preexercise and postexercise GPX activity in adolescents with Down syndrome were 24.8+/-3.1 [23.1 to 26.5] U/g hemoglobin and 29.3+/-2.9 [28.1 to 30.5] U/g hemoglobin, respectively. When compared with baseline values it was increased significantly (24.8+/-3.1 vs. 29.3+/-2.9; P=0.011).


CONCLUSIONS
Regular exercise increased significantly GPX activity. Further studies are required to assess the behavior of other antioxidant enzymes to highlight potential benefits of regular exercise in redox metabolism.
Francisco Javier
Ordonez
O
Human Anatomy and Embryology, Medicine Department, Sport Medicine School, University of Cadiz, Spain.
Manuel
Rosety
R
Manuel
Rosety-Rodriguez
RR
D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism / Q000502:physiology; D004314:Down Syndrome / Q000201:enzymology* / Q000503:physiopathology; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005081:Exercise Therapy; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D000975:Antioxidants; D005979:Glutathione Peroxidase