title: Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.
abstract: A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.
authors.affiliation: Anacor Pharmaceuticals Inc., 1060 East Meadow Circle, Palo Alto, California 94303, USA. sbaker@anacor.com
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Baker
authors.forename: Yong-Kang
authors.initials: YK
authors.lastname: Zhang
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Akama
authors.forename: Agnes
authors.initials: A
authors.lastname: Lau
authors.forename: Huchen
authors.initials: H
authors.lastname: Zhou
authors.forename: Vincent
authors.initials: V
authors.lastname: Hernandez
authors.forename: Weimin
authors.initials: W
authors.lastname: Mao
authors.forename: M R K
authors.initials: MR
authors.lastname: Alley
authors.forename: Virginia
authors.initials: V
authors.lastname: Sanders
authors.forename: Jacob J
authors.initials: JJ
authors.lastname: Plattner
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D014009:Onychomycosis / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D001896:Boron Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; C512998:tavaborole