title: Radiotherapy in the multimodal treatment of extrarenal extracranial malignant rhabdoid tumors.
abstract: Extrarenal extracranial malignant rhabdoid tumors (MRT) are extremely rare and typically lethal. No consensus exists on an optimal treatment approach, and, in particular, the role of radiation therapy (RT) is poorly defined. We report on three children who underwent multimodality treatment including surgery, chemotherapy (CMT), and RT. Two of these patients are alive and without evidence of disease 6(1/2) and 7 years after diagnosis and one has expired. Our limited experience suggests that RT in the setting of CMT and surgery has the potential to prolong survival with acceptable toxicity, but outcomes are inconsistent and further study is necessary.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors.forename: Dev R
authors.initials: DR
authors.lastname: Puri
authors.forename: Paul A
authors.initials: PA
authors.lastname: Meyers
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Kraus
authors.forename: Michael P
authors.initials: MP
authors.lastname: Laquaglia
authors.forename: Leonard H
authors.initials: LH
authors.lastname: Wexler
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Wolden
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D004200:Diseases in Twins; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D006801:Humans; D007223:Infant; D018335:Rhabdoid Tumor / Q000235:genetics / Q000532:radiotherapy*