Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis.
We have analysed the expression during mid-gestation mouse development of the four member LRRTM gene family which encodes type 1 transmembrane proteins containing 10 extracellular leucine rich repeats and a short intracellular tail. Each family member has a developmentally regulated pattern of expression distinct from all other members. LRRTM1 is expressed in the neural tube, otic vesicle, apical ectodermal ridge, forebrain and midbrain up to a sharp central boundary. LRRTM2 is expressed in a subset of progenitors in the neural tube. LRRTM3 is expressed in a half somite wide stripe in the presomitic mesoderm adjacent to the boundary with the most recently formed somite. Additional expression is seen in the neural tube, forebrain and hindbrain. LRRTM4 is expressed in the limb mesenchyme, neural tube, caudal mesoderm and in three distinct regions of the head. Later expression occurs in a subset of the developing sclerotome. Each family member has a unique expression domain within the neural tube.
Haines
Bryan P
BP
Section of Gene Function and Regulation, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.
Rigby
Peter W J
PW
D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology / Q000378:metabolism; D017931:DNA Primers / Q000235:genetics; D047108:Embryonic Development / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011247:Pregnancy; D019170:Somites / Q000378:metabolism
D017931:DNA Primers; C526971:LRRTM1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins