title: Effect of recombinant canine distemper vaccine on antibody titers in previously vaccinated dogs.
abstract: Two canine distemper virus (CDV) vaccine types are currently commercially available: modified-live virus (MLV) vaccines and a canarypox recombinant CDV (rCDV) vaccine (Recombitek, Merial). This study compared the ability of the rCDV vaccine and MLV vaccines to significantly enhance (boost) the antibody response of previously immunized adult and juvenile dogs. A significant (fourfold or greater) increase in titer occurred in significantly more dogs revaccinated with Recombitek C-4 or Recombitek C-6 than with the MLV-CDV vaccines. This study demonstrates that Recombitek, the only vaccine for dogs containing rCDV, is more likely to significantly boost the CDV antibody response in previously vaccinated dogs than are the MLV-CDV vaccines. Because rCDV vaccine can boost the antibody titer of dogs previously vaccinated with an MLV vaccine, it can and should be used when core vaccines are readministered.
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, 2015 Linden Dr, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Larson
authors.forename: T L
authors.initials: TL
authors.lastname: Hageny
authors.forename: C J
authors.initials: CJ
authors.lastname: Haase
authors.forename: R D
authors.initials: RD
authors.lastname: Schultz
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D004216:Distemper / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology*; D004283:Dog Diseases / Q000453:epidemiology / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D007117:Immunization, Secondary / Q000379:methods / Q000662:veterinary*; D008297:Male; D011897:Random Allocation; D016896:Treatment Outcome; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014765:Viral Vaccines