Psychiatric presentation of voltage-gated potassium channel antibody-associated encephalopathy. Case report.
Voltage-gated potassium channel antibody encephalopathy, a rare cause of limbic encephalopathy, typically presents with memory impairment and seizures. Psychiatric symptoms have not been emphasised in the literature. Here we describe a 58-year-old man who presented with panic attacks and psychogenic non-epileptic seizures and, later on, developed delusions and hallucinations and then confusion. He was found to have antibodies to voltage-gated potassium channels. Treatment with immuno-modulatory therapy resulted in almost complete recovery.
Parthasarathi
U D
UD
Cambridgeshire & Peterborough Mental Health NHS Trust, Cambridge, UK. upartha@hotmail.co.uk
Harrower
T
T
Tempest
M
M
Hodges
J R
JR
Walsh
C
C
McKenna
P J
PJ
Fletcher
P C
PC
D000906:Antibodies / Q000032:analysis*; D001927:Brain Diseases / Q000276:immunology / Q000523:psychology*; D003221:Confusion / Q000276:immunology / Q000523:psychology / Q000628:therapy; D003702:Delusions / Q000276:immunology / Q000523:psychology / Q000628:therapy; D006212:Hallucinations / Q000276:immunology / Q000523:psychology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000276:immunology* / Q000523:psychology / Q000628:therapy; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D012640:Seizures / Q000276:immunology / Q000523:psychology / Q000628:therapy; D016896:Treatment Outcome
D000906:Antibodies; D024642:Potassium Channels, Voltage-Gated