title: Reversed-phase ion-pair liquid chromatography of some quaternary ammonium drugs.
abstract: The resolving power of a reversed-phase liquid chromatographic method that makes use of a mobile phase system with two counter-ions of opposite charge (N,N-dimethyloctylamine and sodium octanesulphonate) for the separation of quaternary ammonium drugs, is compared with that obtained using more traditional ion-pairing systems. Efficient, selective and well-resolved separations could only be obtained by the combined effects of the eluent modifiers.
authors.affiliation: Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmaceutical Sciences, State University of Ghent, Harelbekestraat 72, B-9000-Ghent, Belgium.
authors.forename: J A
authors.initials: JA
authors.lastname: De Schutter
authors.forename: P
authors.initials: P
authors.lastname: De Moerloose