title: [Improvement of thrombocytopenia with normalization of thyroid function in a patient with Graves disease].
abstract: A 39-year-old man was admitted to our hospital because of hyperthyroidism complicated with fever, atrial fibrillation with rapid ventricular response and congestive heart failure. Laboratory data revealed pancytopenia with a white blood cell count of 3360/microl, Hb 9.6 g/dl, and a platelet count of 88000/ul. After initiation of treatment with 30 mg of thiamazole daily, the patient's thyroid function improved but 4 weeks later, thiamazole induced agranulocytosis occurred and the drug was discontinued. After recovery from agranulocytosis, a subtotal thyroidectomy was performed, and the patient's pancytopenia rapidly improved. In this case, hyperthyroidism itself appeared to be closely related to the development of thrombocytopenia.
authors.affiliation: Department of Internal Medicine, Nantan General Hospital.
authors.forename: Akio
authors.initials: A
authors.lastname: Okamoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kajita
mesh_terms: D000328:Adult; D006111:Graves Disease / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006980:Hyperthyroidism / Q000601:surgery*; D008297:Male; D013921:Thrombocytopenia / Q000150:complications / Q000503:physiopathology*; D013961:Thyroid Gland / Q000503:physiopathology*; D013965:Thyroidectomy / Q000379:methods*