title: Melatonin and roentgen irradiation of the testis.
abstract: Melatonin is a free-radical scavenger and antioxidant. Roentgen irradiation of testis (animal model formed of albino rats) was associated with destruction and depletion of the germinal epithelial cells. In roentgen-irradiated, melatonin-pretreated animals, these changes were markedly ameliorated. Thus administration of melatonin before irradiation can protect testis from some of the destructive effects of roentgen irradiation.
authors.affiliation: Department of Histopathology, Assir Central Hospital (King Khlid University Teaching Hospitals), Assir, Kingdom of Saudi Arabia. mrh17@swissinfo.org
authors.forename: Mahmoud R
authors.initials: MR
authors.lastname: Hussein
authors.forename: Eman E
authors.initials: EE
authors.lastname: Abu-Dief
authors.forename: Amal T
authors.initials: AT
authors.lastname: Abou El-Ghait
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Adly
authors.forename: Mohamad H
authors.initials: MH
authors.lastname: Abdelraheem
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D011832:Radiation Injuries / Q000473:pathology* / Q000517:prevention & control*; D011836:Radiation Tolerance / Q000187:drug effects*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000293:injuries / Q000473:pathology / Q000528:radiation effects*; D014916:Whole-Body Irradiation / Q000009:adverse effects
chemical_list: D011837:Radiation-Protective Agents; D008550:Melatonin