title: Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults.
abstract: Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA. temesgen.zelalem@mayo.edu
authors.forename: Zelalem
authors.initials: Z
authors.lastname: Temesgen
authors.forename: Francesca
authors.initials: F
authors.lastname: Cainelli
authors.forename: Eric M
authors.initials: EM
authors.lastname: Poeschla
authors.forename: Stacey A R
authors.initials: SA
authors.lastname: Vlahakis
authors.forename: Sandro
authors.initials: S
authors.lastname: Vento
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D024921:Drug Resistance, Multiple, Viral; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006801:Humans; D017211:Treatment Failure; D016896:Treatment Outcome; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D017320:HIV Protease Inhibitors