title: Subclinical left ventricular dysfunction in multiple sclerosis.
abstract: OBJECTIVE
  To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI).
  
  
  METHODS
  A total of 41 patients with definite MS and 32 healthy controls were included in the study.
  
  
  RESULTS
  LV end-systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls (P < 0.05). LV end-diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance.
  
  
  CONCLUSIONS
  These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS.
authors.affiliation: Mustafa Kemal University, Faculty of Medicine, Department of Cardiology, Antakya, Turkey. feritakgul1@yahoo.ca
authors.forename: Ferit
authors.initials: F
authors.lastname: Akgül
authors.forename: Ismet
authors.initials: I
authors.lastname: McLek
authors.forename: Taşkin
authors.initials: T
authors.lastname: Duman
authors.forename: Ergün
authors.initials: E
authors.lastname: Seyfelì
authors.forename: Tunzale
authors.initials: T
authors.lastname: Seydaliyeva
authors.forename: Fatih
authors.initials: F
authors.lastname: Yalçin
mesh_terms: D000328:Adult; D002303:Cardiac Output, Low / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology*; D009205:Myocarditis / Q000000981:diagnostic imaging / Q000276:immunology / Q000503:physiopathology; D009206:Myocardium / Q000276:immunology*; D011237:Predictive Value of Tests; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*