title: Rotavirus infection in Saudi Arabia.
abstract: BACKGROUND
  Human rotavirus, an important causative agent of severe gastroenteritis in infants and young children worldwide, leads to high morbidity in both developing and developed countries, including Saudi Arabia, and high mortality in developing countries. Effective control depends upon an accurate understanding of disease burden and the relative importance of circulating serotypes.
  
  
  METHODS
  We examined the epidemiology and disease burden of rotavirus in Saudi Arabia through a review of 22 published studies of rotavirus and the aetiology of diarrhoea carried out from 1982 to 2003.
  
  
  RESULTS
  The prevalence of rotavirus infection ranged between 10% to 46% with a median of 30%. Most cases were among children less than 2 years of age, and particularly in the first year of life. There were significant differences in seasonality within Saudi Arabia, with increased infection during winter in some cities and during summer in others. G1 was the predominant serotype followed by G4, G3 and G2, in 4 studies where strains had been G-typed. The prevalence of nontypeable strains ranged from 11.0% to 31.3%. No data were available on P types. Results of electropherotyping in 4 studies revealed that the long electropherotype was predominant.
  
  
  CONCLUSIONS
  Rotavirus is an important cause of severe diarrhoea in Saudi children. However, the available data on rotavirus strains in circulation are limited and there is an urgent need for up-to-date and comprehensive studies to evaluate rotavirus strains in circulation and identify unusual types that could be incorporated into future vaccines.
authors.affiliation: Division of Medical Microbiology and Genitourinary Medicine, Faculty of Medicine, University of Liverpool Liverpool, United Kingdom. a.kheyami@liverpool.ac.uk
authors.forename: Ali M
authors.initials: AM
authors.lastname: Kheyami
authors.forename: Nigel A
authors.initials: NA
authors.lastname: Cunliffe
authors.forename: C Anthony
authors.initials: CA
authors.lastname: Hart
mesh_terms: D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D017281:Cost of Illness; D003968:Diarrhea, Infantile / Q000453:epidemiology* / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007223:Infant; D015995:Prevalence; D012401:Rotavirus / Q000145:classification* / Q000235:genetics / Q000276:immunology; D012400:Rotavirus Infections / Q000191:economics / Q000453:epidemiology*; D012529:Saudi Arabia / Q000453:epidemiology; D012621:Seasons
chemical_list: D000956:Antigens, Viral