[Constituents relating to anti-oxidative and alpha-glucosidase inhibitory activities in Yacon aerial part extract].
Hot water extract of the aerial part of Yacon (Smallanthus sonchifolia, Compositae) showed potent free radical-scavenging activity and inhibitory effects on lipid peroxidation in rat brain homogenate. The most potent antioxidative activity focused on the 50% MeOH-eluted fraction on DIAION HP-20 column chromatography. The structure of the major component in the fraction was identified as 2,3,5-tricaffeoylaltraric acid (TCAA) based on spectroscopic evidence. The antioxidative activity of TCAA is superior to that of natural antioxidants such as (+/-)-catechin, alpha-tocopherol, and ellagic acid, and TCAA also showed selective maltase-inhibitory activity (IC(50) 49 microg/ml). As the hypoglycemic activity of Yacon extract was described in a previous report, the present results showing that the aerial part of Yacon has strong antioxidative activity may encourage its potential use as a food supplement to prevent type II diabetes.
Terada
Sumio
S
Research Laboratory, Zenyaku Kogyo Co. Ltd., Tokyo, Japan. Sumio_Terada@mail.zenyaku.co.jp
Ito
Kikuo
K
Yoshimura
Akira
A
Noguchi
Naoto
N
Ishida
Takashi
T
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002109:Caffeic Acids / Q000302:isolation & purification* / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D051381:Rats; D013400:Sugar Acids / Q000302:isolation & purification* / Q000494:pharmacology
C514547:2,3,5-tricaffeoylaltraric acid; D000975:Antioxidants; D002109:Caffeic Acids; D016166:Free Radical Scavengers; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D013400:Sugar Acids