title: [Principles of constructing synbiotic preparations, and evaluation of their clinical effectiveness].
abstract: The problem of constructing means of correction of gastrointestinal microflora is utterly important. The most promising direction here seems to be construction of synbiotics containing a multiprobiotic complex of bifidobacteria and lactobacilli, modeling the microbiocenosis of a certain age group, inulin, as a prebiotic factor and a vitamin and mineral complex. The aim of the study was to evaluate the biologically active food supplement "Normospectrum" vs. the commercial preparation "Bifidumbacterin", its ability to correct the intestinal microflora and the functional condition of the gastrointestinal tract in children. "Normospectrum" was well tolerated, favored regression of the main clinical manifestations, and had positive effect on the intestinal microbiocenosis, increasing the proportion of bifidobacteria, lactobacilli and escherichiae with full enzymatic activity, and lowering the proportion of conditionally pathogenic bacteria and fungi in the intestinal tract. The effects of "Normospectrum" on the functional disturbances of the gastrointestinal tract and the intestinal microflora were much more profound than those of "Bifidumbacterin". Good tolerance and positive effects of the new probiotic preparation "Normospectrum" on the intestinal microbiosis allows recommending it for broad clinical application in children when correction of dysbiotic shifts in the intestinal microflora is necessary.
authors.forename: A M
authors.initials: AM
authors.lastname: Amerkhanova
authors.forename: V A
authors.initials: VA
authors.lastname: Aleshkin
authors.forename: N M
authors.initials: NM
authors.lastname: Gracheva
authors.forename: M S
authors.initials: MS
authors.lastname: Petrova
authors.forename: O P
authors.initials: OP
authors.lastname: Popova
authors.forename: E S
authors.initials: ES
authors.lastname: Zubkova
authors.forename: O G
authors.initials: OG
authors.lastname: Zhilenkova
authors.forename: A A
authors.initials: AA
authors.lastname: Kuralenko
authors.forename: A I
authors.initials: AI
authors.lastname: Solov'eva
mesh_terms: D001688:Biological Products / Q000627:therapeutic use; D019587:Dietary Supplements; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006801:Humans; D017410:Practice Guidelines as Topic; D019936:Probiotics / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D001688:Biological Products; C010546:bifidobacterin