Post traumatic epilepsy: a review of scientific evidence.
Post traumatic epilepsy is the development of recurrent seizures following head trauma and has a high clinical relevance. Several risk factors including some genetic factors increase the susceptibility of post traumatic epilepsy. The precise mechanisms of epileptogenesis in post-traumatic epilepsy are still poorly understood. Many structural, physiologic and biochemical changes in the brain may account for epileptogenesis. The reactive oxygen species (ROS), especially *OH and excitotoxicity are primarily involved. Antioxidants, like tocopherol, antiepileptic drug zonisamide, condensed tannins, melatonin, adenosine, trans-resveratrol, and some other agents have been proposed to prevent epileptogenic focus formation. The review also discusses various aspects of post traumatic epilepsy, mechanisms of epileptogenesis, and clinical implications.
Gupta
Y K
YK
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029. yk.ykgupta@gmail.com
Gupta
Madhur
M
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D001923:Brain Chemistry; D004834:Epilepsy, Post-Traumatic / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000927:Anticonvulsants; D000975:Antioxidants; D017382:Reactive Oxygen Species