Multiple interlinked mechanisms to circumvent DNA replication roadblocks.
DNA replication is a fragile process, since unavoidable lesions in the template DNA cause replicative polymerases to stall, posing a serious threat to genome integrity. Homologous recombination, translesion DNA synthesis and de novo reinitiation of DNA synthesis ensure robust replication by navigating it passed damaged DNA. In this review, we highlight the relationship between these three processes.
Eppink
Berina
B
Department of Cell Biology and Genetics, Erasmus MC, Rotterdam, The Netherlands.
Wyman
Claire
C
Kanaar
Roland
R
D000818:Animals; D004260:DNA Repair; D004261:DNA Replication; D042822:Genomic Instability; D006801:Humans; D011995:Recombination, Genetic