[Expression of c-fos protein after muscle contusion in experimental rats].
OBJECTIVE
To study the relationship between the expression of c-Fos protooncogene and skeleton muscle contusion of rats, and to search for a sensitive marker of timing for skeleton muscle contusion.


METHODS
Fifty Sprague-Dawley rats were randomly distributed into control group and experimental groups. The expression of c-fos was microscopically observed by immunohistochemical method.


RESULTS
With the time prolonged the c-fos positive intensity and area were increased. Positive expression of c-fos protein appeared at 15 min after skeleton muscle contusion, and reached to the peak at 1h after skeleton muscle contusion, then decreased gradually and returned to the normal level on 1d after skeleton muscle contusion.


CONCLUSIONS
The detection of the expression of c-fos protein could be a sensitive marker for timing skeleton muscle contusion.
Yan
Hong-Tao
HT
Forensic Pathology Department, College of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. yanht678@163.com
Li
Bin
B
Yang
Jing
J
Peng
Qi-Yi
QY
Wang
Ye
Y
Xing
Yu
Y
Liao
Zhi-Gang
ZG
Liu
Min
M
D000818:Animals; D003288:Contusions / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006614:Hindlimb / Q000293:injuries*; D007150:Immunohistochemistry; D008297:Male; D018482:Muscle, Skeletal / Q000293:injuries* / Q000378:metabolism* / Q000473:pathology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling; D013997:Time Factors
D016760:Proto-Oncogene Proteins c-fos