Lowering effect of an isoflavone-rich fermented soybean extract on the serum cholesterol concentrations in female rats, with or without ovariectomy, but not in male rats.
We examined the effect of administering an isoflavone-rich fermented soybean extract (FSBE) on the serum cholesterol concentrations in male rats and in intact and ovariectomized (OVX) female rats. Dietary FSBE decreased the serum cholesterol concentrations in intact female and OVX rats, but did not affect the concentrations in male rats. Dietary FSBE increased the hepatic total and esterified cholesterol contents in the intact female rats, but decreased them in the OVX rats. This hypocholesterolemic effect was not a simple estrogenic effect because it has appeared in some reports that estrogen administration decreased serum cholesterol both male and female rats. Dietary FSBE increased the hepatic low-density lipoprotein receptor (LDLR) gene expression in the intact female rats as has previously been reported from many studies, but did not affect that of the OVX rats. Further investigation is needed into the hypocholesterolemic mechanism of FSBE.
Kishida
Taro
T
Department of Biological Resources, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan. kishida@agr.ehime-u.ac.jp
Mizushige
Takafumi
T
Nagamoto
Manabu
M
Ohtsu
Yohhei
Y
Izumi
Tohru
T
Obata
Akio
A
Ebihara
Kiyoshi
K
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000737:chemistry; D005260:Female; D005285:Fermentation; D015870:Gene Expression; D007529:Isoflavones / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010052:Ovariectomy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D011973:Receptors, LDL / Q000378:metabolism; D012737:Sex Factors; D013025:Glycine max / Q000737:chemistry*
D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D007529:Isoflavones; D010936:Plant Extracts; D011973:Receptors, LDL; D002784:Cholesterol