Prognostic factors in the treatment of generalized aggressive periodontitis: I. Clinical features and initial outcome.
OBJECTIVE
The aims of this study were to investigate prognostic factors for initial response to non-surgical periodontal treatment for generalized aggressive periodontitis.


METHODS
Seventy-nine patients with generalized aggressive periodontitis were included in this prospective follow-up intervention study. Patients' clinical and demographic parameters were collected at baseline and 10 weeks following a standard course of treatment (four visits of non-surgical root surface debridement together with OHI as required). The relationship between clinical variables and treatment outcome were analysed at site-specific level by chi(2) analysis and for patient-specific variables by logistic regression.


RESULTS
In general, there was a good response to the treatment provided. In deep sites the mean pocket depth reduction was 2.11+/-2.01 mm. Site-specific analysis showed that the presence of plaque had a small but significant predictive effect on outcome (odds ratio 1.4). Sites on teeth with grade II/III mobility showed a significantly reduced response to treatment. Twenty-five patients were classified as "non-responders". Current smoking was strongly associated with non-responding patients (odds ratio 3.8) in a logistic regression model; plaque, baseline bleeding and initial pocket depth were not significantly associated with treatment outcomes.


CONCLUSIONS
Overall, the results emphasize the importance of smoking as a negative prognostic factor, and suggest that treatment outcomes may be determined by a wide range of different determinants requiring further study.
Hughes
Francis J
FJ
Collaborative Group in Risk Factors for Periodontal Disease, Institute of Dentistry, Queen Mary's School of Medicine, London, UK. f.j.hughes@qmul.ac.uk
Syed
Mahnaz
M
Koshy
Bindhu
B
Marinho
Valeria
V
Bostanci
Nagihan
N
McKay
Ian J
IJ
Curtis
Michael A
MA
Croucher
Raymond E
RE
Marcenes
Wagner
W
D000328:Adult; D015331:Cohort Studies; D003773:Dental Plaque / Q000628:therapy; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000628:therapy; D005884:Gingival Hemorrhage / Q000628:therapy; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009910:Oral Hygiene; D017622:Periodontal Attachment Loss / Q000628:therapy; D010514:Periodontal Pocket / Q000628:therapy; D010518:Periodontitis / Q000628:therapy*; D011379:Prognosis; D011446:Prospective Studies; D016745:Root Planing; D012907:Smoking / Q000009:adverse effects; D013357:Subgingival Curettage; D014086:Tooth Mobility / Q000628:therapy; D016896:Treatment Outcome