Telomeres and telomerase. A survey about methods and recent advances in cancer diagnostic and therapy.
Since the discovery that telomerase is repressed in most normal human somatic cells but strongly expressed in most human tumours, telomerase emerged as an attractive target for diagnostic, prognostic and therapeutic purposes to combat human cancer. In this review, a synopsis of methods detecting telomerase is presented evaluating their potential for diagnostic and prognostic use. Also, the most promising telomerase therapeutics are discussed in the light of recent advances in the field.
Weise
J M
JM
Heinrich-Pette-Institute for Experimental Virology and Immunology, at the University of Hamburg, Hamburg, Germany.
Günes
C
C
D000818:Animals; D001483:Base Sequence; D016922:Cellular Senescence; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008495:Medical Oncology / Q000379:methods*; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D011379:Prognosis; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*; D016615:Telomere / Q000648:ultrastructure*
D019098:Telomerase