Comparison of FK 506, mycophenolate mofetil, and aminoguanidine effects on delay of corneal allograft rejection in an experimental model of low-risk and high-risk keratoplasty.
The purpose of our study was to compare the effectiveness of immunosuppressive drugs on the prevention of allograft rejection in a murine model of low-risk and high-risk keratoplasty. The therapy included FK 506 (tacrolimus; 0.2 mg/kg), mycophenolate mofetil (30 mg/kg), aminoguanidine (0.1 g/kg), and combination of FK506 + mycophenolate mofetil or FK506 + aminoguanidine. The results obtained from the Gray's survival model stratified according to the type of subjects suggest that a major rejection risk reduction was achieved using FK506; good results also were obtained for mycophenolate mofetil. Although the point estimates of both the survival and relative risk of rejection suggest a deferred effect of the combination FK506 + mycophenolate mofetil, this finding did not prove statistically significant.
Svozílková
P
P
Institute of Pharmacology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. psvoz@If1.cuni.cz
Bysterská
P
P
Masek
K
K
Valenta
Z
Z
Zvárová
J
J
Farghali
H
H
D000818:Animals; D003316:Corneal Diseases / Q000628:therapy; D016039:Corneal Transplantation; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006085:Graft Survival / Q000187:drug effects; D006146:Guanidines / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012307:Risk Factors; D016559:Tacrolimus / Q000008:administration & dosage*; D014184:Transplantation, Homologous
D004338:Drug Combinations; D006146:Guanidines; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid; C004479:pimagedine; D016559:Tacrolimus