Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial.
Bonanni
Bernardo
B
Macis
Debora
D
Maisonneuve
Patrick
P
Johansson
Harriet A
HA
Gucciardo
Giacomo
G
Oliviero
Pasquale
P
Travaglini
Roberto
R
Muraca
Maria G
MG
Rotmensz
Nicole
N
Veronesi
Umberto
U
Decensi
Andrea U
AU
D000328:Adult; D000368:Aged; D016588:Anticarcinogenic Agents / Q000378:metabolism*; D018931:Antineoplastic Agents, Hormonal / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D020847:Estrogen Receptor Modulators / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D019584:Hot Flashes / Q000517:prevention & control*; D006801:Humans; D007558:Italy; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016032:Randomized Controlled Trials as Topic; D013629:Tamoxifen / Q000378:metabolism*
D016588:Anticarcinogenic Agents; D018931:Antineoplastic Agents, Hormonal; D020847:Estrogen Receptor Modulators; D013629:Tamoxifen; D019389:Cytochrome P-450 CYP2D6