title: Direct access to enantiomerically enriched alpha-amino phosphonic acid derivatives by organocatalytic asymmetric hydrophosphonylation of imines.
abstract: A simple and efficient organocatalytic enantioselective hydrophosphonylation of imines to enantiomerically enriched alpha-amino phosphonates is reported. By using 10 mol % of quinine as the catalyst in the enantioselective addition of diethyl phosphite to N-Boc protected imines, alpha-amino phosphonates are obtained in moderate to good yields and with up to 94% ee.
authors.affiliation: Department of Organic Chemistry "A. Mangini", University of Bologna, V. Risorgimento 4, 40136 Bologna, Italy. dap@chem.gu.se
authors.forename: Daniel
authors.initials: D
authors.lastname: Pettersen
authors.forename: Mauro
authors.initials: M
authors.lastname: Marcolini
authors.forename: Luca
authors.initials: L
authors.lastname: Bernardi
authors.forename: Francesco
authors.initials: F
authors.lastname: Fini
authors.forename: Raquel P
authors.initials: RP
authors.lastname: Herrera
authors.forename: Valentina
authors.initials: V
authors.lastname: Sgarzani
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ricci