[Distribution of ion channels in pulmonary arterial smooth muscle cells and their roles in hypoxia pulmonary vasoconstriction].
Hypoxic pulmonary vasoconstriction (HPV) is the rapid, reversible increase in pulmonary vascular resistance that occurs when the alveolar oxygen tension falls below a threshold level, thereby achieving ventilation/perfusion matching. HPV is closely related to the state of K+, Ca2+ and Cl- channels in pulmonary arterial smooth muscle cells, which distribute heterogeneously along the longitude of pulmonary artery tree, and cause heterogeneous vasoconstriction response in different part of pulmonary artery in HPV. In this review we summarize current knowledge about the distribution of these ion channels and their roles in HPV.
Hu
Ying
Y
Research Center for High Altitude Medicine of Qinghai University, Xining 810001, China.
Ge
Ri-Li
RL
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology; D018118:Chloride Channels / Q000378:metabolism / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology*; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism / Q000502:physiology; D011651:Pulmonary Artery / Q000166:cytology / Q000378:metabolism / Q000503:physiopathology*; D014018:Tissue Distribution; D014661:Vasoconstriction / Q000502:physiology*
D015220:Calcium Channels; D018118:Chloride Channels; D007473:Ion Channels; D015221:Potassium Channels