The identification, assay and purity determination of chlorpropamide, glibenclamide and tolbutamide and their tablet preparations by thin-layer chromatography.
A thin-layer chromatographic procedure is described for the identification and quantitative determination of chlorpropamide, glibenclamide and tolbutamide in both powder and tablet form. The coefficient of variation of the method is 0.6-0.7%, and results show good agreement with those obtained by the B.P. methods of assay. The TLC procedure has the advantage of greater specificity, and can also be used to identify and limit degradation products that may be present.
Takla
P G
PG
Welsh School of Pharmacy, University of Wales Institute of Science and Technology, King Edward VII Avenue, Cardiff, CF1 3NU, Wales, UK.
Joshi
S R
SR