title: [Effect of lamivudine treatment on the quality of life of chronic hepatitis B].
abstract: OBJECTIVE
  To assess the quality of life of 3 types of chronic hepatitis B before and after the treatment of lamivudine, and to find an ideal way of medical treatment for chronic hepatitis B.
  
  
  METHODS
  One hundred and fifty patients with chronic hepatitis B were investigated in this study, among whom 5 1 were in mild state illness, 53 were middle-range and the other 46 were severe. The quality of life of the patients was assessed by the quality of life questionnaire (SF-36). The marks of questionnaire were compared before and after the use of lamivudine to assess its comprehensive curative effect on chronic hepatitis B.
  
  
  RESULTS
  The total score of SF-36, score of physical function, role-physical, mental health, social function, bodily pain and vitality were significant different before and after the treatment. Statistically significant differences were found among the 3 types of chronic hepatitis B before and after the treatment.
  
  
  CONCLUSIONS
  The quality of life of patients with chronic hepatitis B can be improved by using lamivudine. Assessment of quality of life may be taken as an important index in treating chronic hepatitis B.
authors.affiliation: Department of Infectious Disease, Second Xiangya Hospital, Central South University, Changsha, China. hongmeil@hotmail.com
authors.forename: Lu-xi
authors.initials: LX
authors.lastname: Yi
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
authors.forename: Xiao-wan
authors.initials: XW
authors.lastname: Wang
mesh_terms: D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D011788:Quality of Life; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D011795:Surveys and Questionnaires
chemical_list: D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine