title: In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs.
abstract: In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.
authors.affiliation: University of Western Australia, School of Medicine and Pharmacology, Crawley, Western Australia 6959, Australia. tdavis@cyllene.uwa.edu.au
authors.forename: Timothy M E
authors.initials: TM
authors.lastname: Davis
authors.forename: Juliana
authors.initials: J
authors.lastname: Hamzah
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Ilett
authors.forename: Harin A
authors.initials: HA
authors.lastname: Karunajeewa
authors.forename: John C
authors.initials: JC
authors.lastname: Reeder
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Batty
authors.forename: Sara
authors.initials: S
authors.lastname: Hackett
authors.forename: P Hugh R
authors.initials: PH
authors.lastname: Barrett
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D066298:In Vitro Techniques; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D011804:Quinolines / Q000494:pharmacology*; D010879:Piperazines
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D011804:Quinolines; C034759:piperaquine; D010879:Piperazines