title: Prevalence of EGG derangement in newly diagnosed type 1 diabetes in childhood.
abstract: OBJECTIVE
  To evaluate gastric myoelectrical activity in children with newly diagnosed type 1 diabetes melliltus (T1DM) in relation to blood glucose control and visceral neuropathy.
  
  
  METHODS
  Percutaneous electrogastrograpy (EGG) was performed on 42 children (20 F; mean age 12.9 +/- 3.1 years) with T1DM of <1 year's duration and on 35 healthy controls (18 F; mean age 13.4 +/- 3.6 years). After overnight fasting, a 30-minute EGG recording was followed by test meal consumption and then a 60-minute postprandial EGG aquisition. Fasting and postprandial periods were analyzed for gastric dysrhythmias, dominant frequency (DF) and additional parameters. In T1DM patients, HbA1c and blood glucose levels were measured and tests for visceral neuropathy were performed.
  
  
  RESULTS
  In 41 T1DM patients (98%), cardiovascular neuropathy tests were negative. In 12 of those patients (29%) and in 32 healthy controls (91%), electrogastrograms were normal. The percentages of fasting and postprandial gastric dysrhythmias were significantly higher in T1DM patients compared to controls (P < 0,05). In T1DM children after feeding, some normalization of gastric myoelectrical rhythm was observed: normogastria increased nearly 2-fold to 72.6 +/- 22.9% and bradygastria decreased to 20.8 +/- 20.4% from 52.3 +/- 32.4% (P < 0.05). The percentages of fasting bradygastria and normogastria were correlated with glycemia level (r = -0.55 and r = 0.51, respectively; P < 0.05), as was postprandial DF (r = 0.41; P < 0.05). There was no correlation between HbA1c levels and EGG parameters.
  
  
  CONCLUSIONS
  Derangement of the gastric myoelectrical activity is present in 71% of children with early stage T1DM. Glucose levels influence gastric myoelectrical activity, whereas long-term glucose control (HbA1c level) does not correlate with EGG parameters.
authors.affiliation: Department of Pediatric Allergology, Gastroenterology and Nutrition, Medical University of Lodz, Poland. etka@op.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Toporowska-Kowalska
authors.forename: Krystyna
authors.initials: K
authors.lastname: Wasowska-Królikowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szadkowska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Młynarski
authors.forename: J
authors.initials: J
authors.lastname: Bodalski
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000453:epidemiology; D004576:Electromyography / Q000379:methods*; D005215:Fasting; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D019518:Postprandial Period; D015995:Prevalence; D013270:Stomach / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin