title: Effect of radiofrequency catheter ablation on endothelial function and oxidative stress.
abstract: OBJECTIVE
  Thromboembolic complications commonly occur in radiofrequency (RF) ablation procedures. Endothelial injury is believed to be induced during the process of RF ablation and to be involved in the mechanisms of thromboembolism. In this study, we gave further information about endothelial injury and also investiged the possible reasons for endothelial dysfunction during RF.
  
  
  RESULTS
  Plasma levels of nitric oxide (NO), a biomarker of endothelial injury and some antioxidants and oxidants: beta-carotene (beta-CAR), lipoperoxide (LPO), superoxide dismutase (SOD), vitamin C (VC) and vitamin E (VE) were measured in 44 patients who underwent radiofrequency catheter ablation. Plasma NO concentration decreased significantly from 433.27 +/- 59.93 nmol/L to 407.13 +/- 52.32 nmol/L during RF ablation. Levels of beta-CAR, LPO, SOD,VC and VE were not significantly different. The decrease of plasma NO level was significantly correlated with ablation duration and cumulative ablation energy but had no significant correlation with overall procedure time, output ablation energy, ablation temperature and age of the patients.
  
  
  CONCLUSIONS
  Radiofrequency catheter ablation induced endothelial injury but had no effect on oxidative stress. Radiofrequency energy was the main factor that caused endothelial injury during RF ablation.
authors.affiliation: Department of Cardiology, the Second Affiliated Hospital, Zhejiang University, Medical School, Hangzhou Zhejiang, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Ma
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Shaoxiang
authors.initials: S
authors.lastname: Weng
authors.forename: Xingguang
authors.initials: X
authors.lastname: Lu
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D017115:Catheter Ablation; D004730:Endothelium, Vascular / Q000293:injuries / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D011183:Postoperative Complications / Q000503:physiopathology*; D012307:Risk Factors; D013223:Statistics as Topic; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000503:physiopathology / Q000601:surgery*; D013612:Tachycardia, Ectopic Atrial / Q000503:physiopathology / Q000601:surgery*; D013617:Tachycardia, Supraventricular / Q000503:physiopathology / Q000601:surgery*; D013923:Thromboembolism / Q000503:physiopathology
chemical_list: D000975:Antioxidants; D016877:Oxidants; D009569:Nitric Oxide