title: Investigation of Helicobacter pylori in the middle ear of the patients with chronic otitis media by CLO test and 14C urea breath test.
abstract: OBJECTIVE
  The aim of this study was to investigate the presence of Helicobacter pylori by CLO test in the middle ear of the patients with chronic otitis media. We also investigated the relationship between H. pylori in the stomach and in the middle ear by 14C urea breath test (14C UBT) for the possible source of this bacterium.
  
  
  METHODS
  A prospective controlled clinical study.
  
  
  METHODS
  Tissue samples were obtained from the middle ear mucosa of 41 patients undergoing ear surgery for chronic suppurative otitis media and placed in the CLO test kit. C UBT was performed in 24 patients and 20 normal subjects.
  
  
  RESULTS
  The CLO test results were positive in 22 patients (53.6%). Results of 14C UBT that was performed in 24 patients were positive in 19 patients (79.1%) and were positive in 6 control subjects (30%).
  
  
  CONCLUSIONS
  Fifty-three percent of the middle ear mucosae obtained from 41 patients with chronic otitis media were shown to be positive for H. pylori, and although our results suggest that the source of this bacterium is the stomach, further clinical studies are needed.
authors.affiliation: Otolaryngology Department, Ankara Numune Research and Training Hospital, Ankara, Turkey. mdagli@hotmail.com
authors.forename: Muharrem
authors.initials: M
authors.lastname: Dagli
authors.forename: Adil
authors.initials: A
authors.lastname: Eryilmaz
authors.forename: Adnan
authors.initials: A
authors.lastname: Uzun
authors.forename: Burcak
authors.initials: B
authors.lastname: Kayhan
authors.forename: Hayriye
authors.initials: H
authors.lastname: Karabulut
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001944:Breath Tests / Q000379:methods*; D002247:Carbon Isotopes; D016022:Case-Control Studies; D002648:Child; D018424:Cholesteatoma, Middle Ear / Q000150:complications; D002908:Chronic Disease; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D008297:Male; D008875:Middle Aged; D010035:Otitis Media, Suppurative / Q000150:complications / Q000382:microbiology*; D011446:Prospective Studies; D014508:Urea / Q000032:analysis*
chemical_list: D002247:Carbon Isotopes; D014508:Urea