Collision tumor of malignant skin cancers: a case of melanoma in basal cell carcinoma.
The coexistence of two malignant skin tumors intermingling in the same histologic specimen is rare. We report a case of melanoma in a basal cell carcinoma collision tumor. The presence of two intermingled neoplasms was confirmed by immunohistochemistry, which showed strong positivity for S-100 and HMB-45. A review of the literature and a case analysis allow for some pathogenetic and prognostic considerations.
Papa
Giovanni
G
Department of Plastic and Reconstructive Surgery, University of Trieste, Ospedale di Cattinara, Strada di Fiume 447, Trieste, Italy. chirurgia-plastica@aots.sanita.fvg.it
Grandi
Giorgio
G
Pascone
Michele
M
D000368:Aged; D000951:Antigens, Neoplasm; D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002610:Cheek / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000378:metabolism; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins