title: Core/shell quantum-dot-photosensitized nano-TiO2 films: fabrication and application to the damage of cells and DNA.
abstract: Through the use of monodisperse core/shell quantum dots (QDs) as photosensitizers for the first time, a novel strategy for the fabrication of QD-photosensitized nano-TiO2 films was demonstrated. Core/shell QDs were self-assembled on nano-TiO2 films through carboxyls as anchoring groups to metal oxides. Atomic force microscopy and some other experiments showed the fabrication strategy is successful. Reactive oxygen species detection experiments indicated that such films have photosensitization ability. The results of bactericidal and DNA damage experiments demonstrate that such films have excellent photoactivity.
authors.affiliation: College of Chemistry and Molecular Sciences and State Key Laboratory of Virology, Wuhan University, Wuhan 430072, People's Republic of China.
authors.forename: Zhe-Xue
authors.initials: ZX
authors.lastname: Lu
authors.forename: Zhi-Ling
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Ming-Xi
authors.initials: MX
authors.lastname: Zhang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Xie
authors.forename: Zhi-Quan
authors.initials: ZQ
authors.lastname: Tian
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.forename: Dai-Wen
authors.initials: DW
authors.lastname: Pang
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004249:DNA Damage; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D008567:Membranes, Artificial; D049329:Nanostructures / Q000737:chemistry*; D010777:Photochemistry; D045663:Quantum Dots; D017382:Reactive Oxygen Species / Q000032:analysis / Q000737:chemistry; D012680:Sensitivity and Specificity; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D008567:Membranes, Artificial; D017382:Reactive Oxygen Species; C009495:titanium dioxide; D004247:DNA; D014025:Titanium