[Development of testing kits of anti-ganglioside antibody: clinical utility in Guillain-Barré and Fisher syndromes].
We developed testing kits for anti-GM1 and anti-GQ1b IgG antibodies and examined their utilities in supporting the diagnosis of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS). Anti-GM1 antibody was detected in 49% of 95 patients with GBS and in 5% or less of disease and normal controls. Anti-GQ1b antibody was detected in 85% of 55 patients with FS, whereas in none of the controls. Eight GBS patients, in whom anti-GM1 IgG antibody was judged negative using the kit, were found to have other anti-ganglioside IgG antibodies. Four of them showed ophthalmoplegia and had anti-GQ1b IgG antibody. Detection of anti-GM1 IgG antibody in GBS and of anti-GQ1b IgG antibody in FS within one week after the disease onset were significantly more frequent compared to albuminocytologic dissociation in the cerebrospinal fluids (GBS, 58% vs 32%; FS, 89% vs 20%). These findings indicate that our testing kits are useful for supporting the early diagnosis of GBS and FS.
Akiyama
Mayumi
M
Shino-Test Corporation, 2-29-14 Oonodai, Sagamihara-shi, Kanagawa 229-0011, Japan.
Koga
Michiaki
M
Yoshino
Hiide
H
Hamaoka
Akira
A
Noguchi
Yasuhiko
Y
Hirata
Koichi
K
Yuki
Nobuhiro
N
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000175:diagnosis*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000175:diagnosis*; D011933:Reagent Kits, Diagnostic / Q000592:standards*
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; D011933:Reagent Kits, Diagnostic; D005677:G(M1) Ganglioside; C039129:GQ1b ganglioside