Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease.
To investigate the effect of single nucleotide polymorphisms (SNPs) of the upstream stimulatory factor (USF) 1 and 2 genes on the onset of Alzheimer's disease (AD), a case-control study was performed. The SNPs were genotyped by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 236 AD patients and 120 age-matched controls of Japanese descent. We observed no significant association between the three SNPs of the USF 1 gene and AD in our Japanese participants. In addition, the SNPs studied did not affect plasma cholesterol levels in our AD cases. For the USF 2 gene, the two SNPs did not show significant association with onset of AD. Our study suggests that the three SNPs of the USF 1 gene and two SNPs of the USF 2 gene presented here are not associated with onset of AD.
Shibata
Nobuto
N
Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan. nobuto.shibata@nifty.ne.jp
Ohnuma
Tohru
T
Higashi
Shinji
S
Higashi
Maiko
M
Usui
Chie
C
Ohkubo
Taku
T
Watanabe
Tomoko
T
Kawashima
Ritsuko
R
Kitajima
Akiyoshi
A
Ueki
Akira
A
Nagao
Masatsugu
M
Arai
Heii
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D018709:Statistics, Nonparametric; D051720:Upstream Stimulatory Factors / Q000235:genetics*
C497181:USF1 protein, human; C497184:USF2 protein, human; D051720:Upstream Stimulatory Factors