title: Antibody response after single-visit full-mouth ultrasonic debridement versus quadrant-wise therapy.
abstract: BACKGROUND
  The aim of this study was to compare serum antibody responses to periodontal pathogens after single-visit full-mouth ultrasonic debridement and quadrant-wise therapy.
  
  
  METHODS
  Thirty-six subjects with chronic periodontitis were randomized into three groups: quadrant-wise debridement in four visits, one-visit full-mouth debridement with water and with povidone iodine. Blood samples were collected before and immediately after treatment and 1, 3 and 6 months post-therapy. Serum antibody titres and avidity to Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia and Treponema denticola were determined by enzyme-linked immunosorbent assay (ELISA) and thiocyanate ELISA, respectively.
  
  
  RESULTS
  IgG titres to P. gingivalis significantly decreased at 1, 3 and 6 months in full-mouth debridement with water group, while significant reductions were seen only at 3 and 6 months after quadrant-wise debridement. Both full-mouth groups showed significant reduction in IgG titres to A. actinomycetemcomitans at 3 and 6 months. Significant increases in antibody avidity to P. gingivalis and A. actinomycetemcomitans were noted 3 months following full-mouth debridement with povidone.
  
  
  CONCLUSIONS
  Both full-mouth and quadrant treatments generally resulted in a decrease in antibody titres and increase in antibody avidity. Full-mouth debridement induced an earlier reduction of IgG titre to P. gingivalis and A. actinomycetemcomitans, than quadrant-wise therapy.
authors.affiliation: Periodontology, Department of Hard Tissue Engineering,Tokyo Medical and Dental University, Tokyo, Japan. wdq.peri@tmd.ac.jp
authors.forename: Dongqing
authors.initials: D
authors.lastname: Wang
authors.forename: Geena
authors.initials: G
authors.lastname: Koshy
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kawashima
authors.forename: Makoto
authors.initials: M
authors.lastname: Kiji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nitta
authors.forename: Shigeru
authors.initials: S
authors.lastname: Oda
authors.forename: Isao
authors.initials: I
authors.lastname: Ishikawa
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans / Q000276:immunology; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D000915:Antibody Affinity / Q000276:immunology; D002908:Chronic Disease; D003773:Dental Plaque / Q000382:microbiology; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D010518:Periodontitis / Q000276:immunology / Q000382:microbiology / Q000628:therapy; D016966:Porphyromonas gingivalis / Q000276:immunology; D011206:Povidone-Iodine / Q000627:therapeutic use; D018713:Prevotella intermedia / Q000276:immunology; D012463:Saliva / Q000382:microbiology; D016037:Single-Blind Method; D013357:Subgingival Curettage / Q000379:methods*; D048373:Treponema denticola / Q000276:immunology; D014464:Ultrasonic Therapy
chemical_list: D000891:Anti-Infective Agents, Local; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D011206:Povidone-Iodine