title: Recurrent neural tube defects.
abstract: We report a case of recurrent neural tube defects in a 30-year-old multigravida with no medical or family history of note. She presented with a significant history of having three (out of four) previous pregnancies affected by neural tube defects diagnosed at the 20-week foetal anomaly ultrasonographical scans, and which resulted in mid-trimester pregnancy terminations. Previous investigations for the foetuses did not yield any obvious cause. We discuss the possible differential diagnoses and aetiological factors. Rare causes of neural tube defects need to be excluded in recurrent cases with no obvious aetiology.
authors.affiliation: Department of General Obstetrics and Gynaecology, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore 229899. shenligoh@hotmail.com
authors.forename: S L
authors.initials: SL
authors.lastname: Goh
authors.forename: J V K
authors.initials: JV
authors.lastname: Tan
authors.forename: K Y C
authors.initials: KY
authors.lastname: Kwek
authors.forename: G S H
authors.initials: GS
authors.lastname: Yeo
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009436:Neural Tube Defects / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors