Genetic polymorphisms of vascular endothelial growth factor and angiopoietin 2 in retinopathy of prematurity.
Angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2) contribute to development of retinopathy of prematurity (ROP). We aimed to test whether polymorphisms of these factors are associated with ROP. VEGF(-2578) and Ang2(-35) polymorphisms were analyzed with PCR-RFLP method in 200 preterm infants without ROP or with ROP stages 1-5. Our results suggest that there is no association between carrier state of VEGF(-2578) and Ang2(-35) and risk of ROP in preterm infants. The prevalence of VEGF(-2578) "A" allele was lower in preterm boys with severe ROP (stages 4-5) than in those without or with mild ROP (stages 1-3).
Bányász
Ilona
I
1st Department of Paediatrics, Semmelweis University, Budapest, Hungary. banyasz@gyer1@sote.hu
Bokodi
Géza
G
Vannay
Adám
A
Szebeni
Beáta
B
Treszl
András
A
Vásárhelyi
Barna
B
Tulassay
Tivadar
T
Szabó
András
A
D000483:Alleles; D042702:Angiopoietin-2 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012178:Retinopathy of Prematurity / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
D042702:Angiopoietin-2; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D004247:DNA