title: A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation.
abstract: Numerous single-institutional studies and a large pooled analysis have demonstrated that the presence of disseminated tumor cells (DTCs) in the bone marrow (BM) from patients with primary, nonmetastatic breast cancer (Stages I-III) is associated with impaired prognosis. To date, sampling of BM and assessment of DTCs is not considered a routine procedure in the clinical management of breast cancer patients; however, emerging data suggest a future role for risk stratification and monitoring of therapeutic efficacy. Because these clinical options need to be evaluated in trials to verify the principle of this concept in the clinical setting, agreement on the standardized detection of DTCs is necessary. Consequently, the German, Austrian, and Swiss Societies for Senology recently formed a panel 1) to review and discuss the existing methodologies, 2) to find a consensus for a standardized detection of DTCs, and 3) to explore the options for its clinical implementation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tubingen, Tubingen, Germany. tanja.fehm@med.uni-tuebingen.de
authors.forename: Tanja
authors.initials: T
authors.lastname: Fehm
authors.forename: Stephan
authors.initials: S
authors.lastname: Braun
authors.forename: Volkmar
authors.initials: V
authors.lastname: Muller
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Janni
authors.forename: Gerhard
authors.initials: G
authors.lastname: Gebauer
authors.forename: Christian
authors.initials: C
authors.lastname: Marth
authors.forename: Christian
authors.initials: C
authors.lastname: Schindlbeck
authors.forename: Diethelm
authors.initials: D
authors.lastname: Wallwiener
authors.forename: Elin
authors.initials: E
authors.lastname: Borgen
authors.forename: Bjorn
authors.initials: B
authors.lastname: Naume
authors.forename: Klaus
authors.initials: K
authors.lastname: Pantel
authors.forename: Erich
authors.initials: E
authors.lastname: Solomayer
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination / Q000592:standards*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005260:Female; D006412:Hematopoietic Stem Cells / Q000145:classification; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods / Q000592:standards; D011379:Prognosis; D012306:Risk; D013997:Time Factors