title: Liquid-solid sample preparation in drug analysis.
abstract: This article compares liquid-solid extraction (LSE) with the more conventional liquid-liquid extraction (LLE) for the preparation of biological samples for assay. The commercially available manual LSE methods, Sep-Pak and Bond Elut, as well as the automated instruments Prep and Analytichem Automated Sample Processor (AASP), are reviewed. Using examples from the literature and the authors' own experiences a practical guide is given to the advantages and disadvantages of LSE.
authors.affiliation: Department of Drug Analysis, Smith Kline & French Research Limited, The Frythe, Welwyn, Herts, AL6 9AR, UK.
authors.forename: R D
authors.initials: RD
authors.lastname: McDowall
authors.forename: J C
authors.initials: JC
authors.lastname: Pearce
authors.forename: G S
authors.initials: GS
authors.lastname: Murkitt