title: Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue.
abstract: We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the insertion of the aromatic residue could increase the reactivity of the amino group on oligonucleotides in comparison with conventional amino-modification.
authors.affiliation: Research Institute of Genome-based Biofactory, National Institute of Advanced Industrial Science and Technology, AIST, 2-17-2-1 Tsukisamu-Higashi, Sapporo 062-8517, Japan.
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kojima
authors.forename: Maiko
authors.initials: M
authors.lastname: Sugino
authors.forename: Akiko
authors.initials: A
authors.lastname: Mikami
authors.forename: Ken
authors.initials: K
authors.lastname: Nonaka
authors.forename: Yumi
authors.initials: Y
authors.lastname: Fujinawa
authors.forename: Isamu
authors.initials: I
authors.lastname: Muto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsubara
authors.forename: Eiko
authors.initials: E
authors.lastname: Ohtsuka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Komatsu
mesh_terms: D000588:Amines / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis*; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D003432:Cross-Linking Reagents; D009841:Oligonucleotides; D011084:Polycyclic Aromatic Hydrocarbons