title: Strict preparation and evaluation of water-soluble hat-stacked carbon nanofibers for biomedical application and their high biocompatibility: influence of nanofiber-surface functional groups on cytotoxicity.
abstract: Water-soluble H-CNFs modified with a carboxyl group possessed the ability to induce TNF-alpha, whereas CHAPS-treated H-CNFs possessed significantly greater activity and were also found to activate NF-kappaB reporter activity, to a significantly greater level than H-CNFs; furthermore the functional group modified or coated on the surface of H-CNFs was a significant cytotoxic factor that affected cell activation.
authors.affiliation: Graduate School of Environmental Studies, Tohoku Univesity, Aramaki, Sendai, Japan. hige@buckyl.tohoku.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sato
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Shibata
authors.forename: Hideo
authors.initials: H
authors.lastname: Kataoka
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Ogino
authors.forename: Fugetsu
authors.initials: F
authors.lastname: Bunshi
authors.forename: Atsuro
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Kazuchika
authors.initials: K
authors.lastname: Tamura
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Akasaka
authors.forename: Motohiro
authors.initials: M
authors.lastname: Uo
authors.forename: Kenichi
authors.initials: K
authors.lastname: Motomiya
authors.forename: Balachandran
authors.initials: B
authors.lastname: Jeyadevan
authors.forename: Rikizo
authors.initials: R
authors.lastname: Hatakeyama
authors.forename: Fumio
authors.initials: F
authors.lastname: Watari
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tohji
mesh_terms: D002244:Carbon / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014867:Water / Q000737:chemistry
chemical_list: D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D014867:Water; D002244:Carbon