title: Cocaine use in an urban medical population and the development of angiographically significant coronary artery disease.
abstract: Cocaine is a common drug of abuse in the United States. Although long-term cocaine use has been associated with premature coronary artery disease (CAD), the relationship between cocaine use and the presence of angiographically significant CAD (> or =70%) is not clear. A retrospective analysis of all patients who had undergone cardiac catheterization at an urban medical center over a 1-year period was performed. Five hundred twelve patients were enrolled in the study; 84 (16.4%) had evidence of cocaine use, and 111 (21.7%) were admitted with a myocardial infarction. At the time of cardiac catheterization, 31 (36.9%) cocaine-positive patients had > or =70% stenosis in at least one epicardial vessel, compared with 200 (46.7%) cocaine-negative patients (p = 0.09). Although a trend toward an association was noted on unadjusted analysis, after adjusting for CAD risk factors, cocaine use was not associated with angiographically significant CAD (odds ratio, 0.9; 95% confidence interval, 0.55-1.5; p = 0.7).
authors.affiliation: Emory University School of Medicine, Division of Cardiology, Atlanta, GA 30303, USA.
authors.forename: Amar D
authors.initials: AD
authors.lastname: Patel
authors.forename: Srikanth
authors.initials: S
authors.lastname: Sola
authors.forename: Patrick
authors.initials: P
authors.lastname: Caneer
authors.forename: Faiz A
authors.initials: FA
authors.lastname: Cheema
authors.forename: Divya
authors.initials: D
authors.lastname: Gupta
authors.forename: Tarek
authors.initials: T
authors.lastname: Helmy
authors.forename: Bobby V
authors.initials: BV
authors.lastname: Khan
mesh_terms: D006328:Cardiac Catheterization / Q000379:methods; D003042:Cocaine; D000075202:Contraindications; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009294:Narcotics; D012189:Retrospective Studies; D012307:Risk Factors; D014505:Urban Population
chemical_list: D009294:Narcotics; D003042:Cocaine