[A molecular epidemiological study on human plague fulminant epidemic in Qinghai, 2004].
OBJECTIVE
To study the epidemiology of genotyping Yersinia pestis isolated in the fulminant epidemics of human plague in Qinghai province in 2004.


METHODS
Primer pairs targeting the twenty-three different identified regions (DFRs) were designed to detect the presence or deletion of each DFR in 13 strains of Yersinia pestis isolated from the fulminant epidemic of human plague in Qinghai province in 2004.


RESULTS
There were 4 genomovars, i.e. Genomovar 8, 10, 15 and 16 in the 13 strains of Yersinia pestis identified. The genomovar of all the strains of Yersinia pestis isolated from Nangqian county was Genomovar 10. Among the two strains of Yersinia pestis isolated from Wulan county, the genomovar of one strain was Genomovar 8 and the other was Genomovar 10. The genomovars of all the strains of Yersinia pestis isolated from Qilian, Qumalai and Chengduo county belonged to Genomovar 16.


CONCLUSIONS
It was demonstrated that the genotyping of Yersinia pestis appeared to be a powerful tool for investigating human plague epidemics.
Qi
Zhi-zhen
ZZ
Qinghai Provincial Institute for Endemic Disease Prevention and Control, Xining 811602, China.
Dai
Er-hei
EH
Zhou
Dong-sheng
DS
Yang
Yong-hai
YH
Yu
Shou-hong
SH
Dai
Rui-xia
RX
Zhao
Hai-hong
HH
Li
Min
M
Yang
Rui-fu
RF
D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D010930:Plague / Q000453:epidemiology*; D015010:Yersinia pestis / Q000235:genetics* / Q000302:isolation & purification