title: Oxidative stress and Alzheimer disease: the autophagy connection?
abstract: Intraneuronal accumulation of amyloid beta-protein (Abeta) is believed to be responsible for degeneration and apoptosis of neurons and consequent senile plaque formation in Alzheimer disease (AD), the main cause of senile dementia. Oxidative stress, an early determinant of AD, has been recently found to induce intralysosomal Abeta accumulation in cultured differentiated neuroblastoma cells through activation of macroautophagy. Because Abeta is known to destabilize lysosomal membranes, potentially resulting in apoptotic cell death, this finding suggests the involvement of oxidative stress-induced macroautophagy in the pathogenesis of AD.
authors.affiliation: Division of Geriatric Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. linzh@inr.liu.se
authors.forename: Lin
authors.initials: L
authors.lastname: Zheng
authors.forename: Jan
authors.initials: J
authors.lastname: Marcusson
authors.forename: Alexei
authors.initials: A
authors.lastname: Terman
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000502:physiology; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D007425:Intracellular Membranes / Q000473:pathology; D008247:Lysosomes / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides