title: Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers.
abstract: This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
authors.affiliation: Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Seoul 130-701, Republic of Korea. ljy@khu.ac.kr
authors.forename: Jae Yeol
authors.initials: JY
authors.lastname: Lee
authors.forename: Seong Jun
authors.initials: SJ
authors.lastname: Park
authors.forename: Sung Jun
authors.initials: SJ
authors.lastname: Park
authors.forename: Min Joo
authors.initials: MJ
authors.lastname: Lee
authors.forename: Hyewhon
authors.initials: H
authors.lastname: Rhim
authors.forename: Seon Hee
authors.initials: SH
authors.lastname: Seo
authors.forename: Ki-Sun
authors.initials: KS
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D020747:Calcium Channels, T-Type; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002121:Calcium Channel Blockers; D020747:Calcium Channels, T-Type; D002118:Calcium