[Association between primary osteoarthrosis and metabolic syndrome according to data from arthroscopic and cytochemical studies].
The aim of the study was to investigate the influence of metabolic syndrome (MS) on the clinical course of osteoarthrosis (OA). The level of neutrophilic free radical production and the condition of antioxidative protection of blood was determined in 72 patients with OA. The tests used in the study included nitro blue tetrazole reduction test (NBTRT), measurement of cellular myeloperoxidase and glutathione reductase (GR) activity, as well as measurement of blood levels of catalase, malonic dialdehyde (MDA), and circulating immune complexes. Twenty-two (30.5%) OA patients underwent arthroscopy. Patients suffering from OA with MS had stage IV of erosive knee joint cartilage lesion significantly more frequently. This was accompanied by higher levels of triglycerides and MDA, as well as an increase in NBTRT results, a decrease in blood catalase activity and the neutrophilic level of GR. The correlation of erosive cartilage changes was the strongest in OA patients who had hyperglycemia upon admission. Thus, the presence of MS in patients with OA is accompanied by more severe cartilage lesions, which are associated with the development of oxidative stress against the background of dyslipidemia.
Kratnov
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Kuryleva
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KV
Kratnov
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AA
D001182:Arthroscopy / Q000379:methods*; D002356:Cartilage / Q000473:pathology; D005260:Female; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D010003:Osteoarthritis / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D012720:Severity of Illness Index