The yjeQ gene is required for virulence of Staphylococcus aureus.
Gene products required for in vivo growth and survival of Staphylococcus aureus and other pathogens represent new targets for antimicrobial chemotherapy. In this study we created a Staphylococcus aureus yjeQ deletion strain and tested its virulence using a mouse kidney abscess infection model. The yjeQ deletion strain was compromised for growth in vitro and severely attenuated for virulence. We concluded that yjeQ is an attractive and novel new drug target.
Campbell
Tracey L
TL
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5.
Henderson
James
J
Heinrichs
David E
DE
Brown
Eric D
ED
D000038:Abscess / Q000382:microbiology / Q000473:pathology*; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D020558:GTP Phosphohydrolases / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D006801:Humans; D007674:Kidney Diseases / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D014774:Virulence
D001426:Bacterial Proteins; D020558:GTP Phosphohydrolases