title: [Clinical study of lacrimal gland tumor involving anterior and middle cranial fossae].
abstract: OBJECTIVE
  To investigate the clinical manifestations of lacrimal gland tumor involving the anterior and middle cranial fossae and the effect of transcranial-orbital approach in treatment of such tumor.
  
  
  METHODS
  A retrospective study was conducted on the clinical data of 23 cases lacrimal gland tumor involving the anterior and middle cranial fossae confirmed by radiological examination, including 11 cases of adenoid cystic carcinoma, 6 cases of pleomorphic adenocarcinoma (malignant mixed tumor), 2 cases of adenocarcinoma, 1 case of squamous cell carcinoma, 1 case of ductal carcinoma, 1 case of mucoepidermoid carcinoma, and 1 case of benign mixed tumor, 15 males and 8 females, aged 42.5 (2 - 76), with a case history of 43 months (2 months to 27 years), with the chief complaints of progressive proptosis, disgenesia of the eye ball, and orbit pain, all undergoing transcranial-orbital operation from August 1998 to February. 2006. Follow up was conducted for 1 month to 7 years.
  
  
  RESULTS
  Postoperatively, ophthalmoplegia was found in 4 cases, and blindness in 1 case. There was no operative death or other significant complication. Recurrence of tumor occurred in 4 cases, and 1 case died from distant metastasis of adenocarcinoma.
  
  
  CONCLUSIONS
  Malignant lacrimal gland tumors, mainly adenoid cystic carcinomas, incline to involve the anterior and middle cranial fossae. Adequate orbital apex decompression and exposure of the tumor can result from suitable transcranial-orbital approach. However, complete surgical excision is difficult, and the tumor has a tendency to recur post-operatively. Suitable treatment strategy should by combination of operation with irradiation or chemotherapy. Prognosis is poor.
authors.affiliation: Department of Neurosurgery, Beijing Tongren Hospital, Capital University of Medical Science, Beijing 100730, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Tian-ming
authors.initials: TM
authors.lastname: Zhang
authors.forename: Yu-zhi
authors.initials: YZ
authors.lastname: An
authors.forename: Ji-tong
authors.initials: JT
authors.lastname: Shi
authors.forename: Ji-di
authors.initials: JD
authors.lastname: Fu
authors.forename: E
authors.initials: E
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D035262:Cranial Fossa, Anterior; D035301:Cranial Fossa, Middle; D003399:Craniotomy; D005134:Eye Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007765:Lacrimal Apparatus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery