MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women.
OBJECTIVE
The aim of our study was to examine genetic variability in the gene encoding methylenetetrahydrofolate reductase (MTHFR) and individual susceptibility to the placental abruption or preeclampsia.


METHODS
362 women (133 with preeclampsia, 117 with placental abruption, and 112 healthy controls) were genotyped for C677T polymorphism in the MTHFR gene.


RESULTS
Similar genotype distributions were observed in the frequencies of C/C homozygotes (58.6%, 64.1%, and 57.1% for the three groups, respectively) and mutant homozygotes T/T (9.0%, 5.1% and 5.4%). No significant differences were detected in T allele frequencies (25.2%, 20.5%, and 24.1% for the three groups, respectively).


CONCLUSIONS
MTHFR C677T polymorphism does not have a major role in the development of preeclampsia or placental abruption in the Finnish population.
Jääskeläinen
Ester
E
Department of Obstetrics and Gynecology, Kuopio University and University Hospital, Kuopio, Finland.
Keski-Nisula
Leea
L
Toivonen
Sari
S
Romppanen
Eeva-Liisa
EL
Helisalmi
Seppo
S
Punnonen
Kari
K
Heinonen
Seppo
S
D000037:Abruptio Placentae / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D003596:Cytosine; D005260:Female; D005387:Finland; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D013941:Thymine
D003596:Cytosine; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013941:Thymine