title: Ventilator associated pneumonia and transfusion, is there really an association? (the NAVTRA study).
abstract: BACKGROUND
  Anemic syndrome is a frequent problem in intensive care units. The most probable etiology is the suppression of the erythropoietin response due to the direct effects of cytokines, as well as frequent blood sampling. Transfusions are not free of complications, therefore transfusion reactions are estimated to occur in 2% of the total packed red blood cells (pRBCs) transfused. In the past several years, several trials had tried to compare the restrictive with the more liberal use of transfusions, and they were found to be equally effective. Nosocomial pneumonia is the most common nosocomial infection in intensive care units; the prevalence is 47% with an attributive mortality of 33%. There are multiple risk factors for the development of nosocomial pneumonia. Colonization of the upper airways is the most important pathophysiological factor but there are other factors implicated like, sedation techniques, inappropriate use of antibiotics and recumbent positioning.A secondary analysis of the CRIT study describes transfusion therapy and its practices in the United States. They found that transfusion practice is an independent risk factor for the development of nosocomial pneumonia.
  
  
  METHODS
  This is a multicenter, prospective cohort study in different intensive care units in Colombia. A total of 474 patients were selected who had more than 48 hours of mechanical ventilation. The primary objective is to try to demonstrate the hypothetical relationship between the use of transfusions and nosocomial pneumonia.Secondly, we will try to determine which other factors are implicated in the development of pneumonia in intensive care units and describe the incidence of pneumonia and transfusion practices.
  
  
  CONCLUSIONS
  Ventilator associated pneumonia is a primary problem in the intensive care unit, multiple factors have been associated with its presence in this study we try to explore the possible association between pneumonia and transfusion, describe all other factors associated with this, and the possible association with other nosocomial infections.
authors.affiliation: Department of critical care, Clinica Universitaria Bolivariana and Clinica CES, Department of epidemiology, University CES, Medellín, Colombia. dyepesmx@yahoo.com.mx
authors.forename: David
authors.initials: D
authors.lastname: Yepes
authors.forename: Bladimir
authors.initials: B
authors.lastname: Gil
authors.forename: Olga
authors.initials: O
authors.lastname: Hernandez
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Murillo
authors.forename: Marco
authors.initials: M
authors.lastname: Gonzalez
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Velasquez
mesh_terms: D015331:Cohort Studies; D003428:Cross Infection / Q000209:etiology*; D006801:Humans; D011014:Pneumonia / Q000382:microbiology*; D011446:Prospective Studies; D012107:Research Design; D012121:Respiration, Artificial / Q000009:adverse effects*; D065227:Transfusion Reaction