title: [Therapeutic angiogenesis: present status of development].
abstract: Despite the enormous progress and scientific developments dedicated to the field of peripheral vascular diseases, in so diverse areas of activity such pathogenesis, methods of diagnosis and therapeutic modalities, the truth is that many failures still occur, occasionally, carrying serious consequences not only with vital implications, but also with limitations of quality of life, autonomy and well-being. These facts stimulated the search for new therapeutic alternatives. Recently, a new method has been developed, the therapeutic angiogenesis, with promising results, based on animal experimentation and also from clinical utilization, allowing already some significant conclusions. The present status of development of therapeutic angiogenesis, its intimal mechanisms and a critical analysis on its clinical utilization are the main subject of the present review, made by the author.
authors.affiliation: Clinica Universitária de Cirurgia Vascular do Hospital de Santa Maria.
authors.forename: Orlanda
authors.initials: O
authors.lastname: Castelbranco
mesh_terms: D000818:Animals; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D014652:Vascular Diseases / Q000628:therapy*