NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.
Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the IkappaB kinase (IKK) complex, the central component of the nuclear factor (NF)-kappaB signaling cascade. Two new papers demonstrate that NF-kappaB essential modulator (NEMO)-IKKgamma, the structural and regulatory component of the IKK complex, specifically recognizes Lys63 polyubiquitin chains attached to the receptor-interacting protein (RIP)1 kinase following tumor necrosis factor treatment, and that this recognition is a requirement for IKK activation.
Israël
Alain
A
Unité de Signalisation Moléculaire et Activation Cellulaire, URA 2582 CNRS Institut Pasteur, 75015 Paris, France. aisrael@pasteur.fr
D004789:Enzyme Activation; D051550:I-kappa B Kinase / Q000276:immunology / Q000378:metabolism; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism*; D014452:Ubiquitins / Q000276:immunology / Q000378:metabolism*
D016328:NF-kappa B; D014452:Ubiquitins; D051550:I-kappa B Kinase