title: The use of contrast media in deceased kidney donors does not affect initial graft function or graft survival.
abstract: Patients receiving cadaveric kidney transplants often experience delayed graft function. As iodinated contrast media injection (ICMI), necessary for cerebral angiography, which is often used to diagnose brain death, can be nephrotoxic, we compared renal function recovery (RFR) and 1-year and long-term graft survival according to the method used to diagnose brain death. Data from 9921 cadaveric kidneys, transplanted between 1 January 1998 and 31 December 2003, were retrieved from the French National Registry for organ donation. We defined RFR as the number of days for the recipient to reach a plasma creatinine less than 250 mumol/l, and/or a 24-h urine output greater than 1000 ml. RFR and 1-year and long-term graft survival were compared between four different donor groups (according to ICMI and diabetes mellitus). A total of 41.5% of deceased donors received ICMI before organ procurement and 1.95% of them were diabetic. History of ICMI or diabetes in the donor did not influence RFR or 1-year graft survival. Long-term graft survival was decreased in the group of patients transplanted with a diabetic graft as compared to patients transplanted with a non-diabetic graft (P=0.001). History of ICMI in the donor did not affect long-term graft survival in the non-diabetic donor group (P=0.2); however, in the diabetic group, ICMI tended to decrease long-term graft survival (P=0.056). ICMI did not affect RFR or graft survival in non-diabetic deceased donors. However, its use in diabetic deceased donors requires further study.
authors.affiliation: Department of Nephrology A, Tenon Hospital, Assistance Publique Hôpitaux de Paris, Paris, France. cecile.vigneau@mssm.edu
authors.forename: C
authors.initials: C
authors.lastname: Vigneau
authors.forename: J-P
authors.initials: JP
authors.lastname: Fulgencio
authors.forename: A
authors.initials: A
authors.lastname: Godier
authors.forename: Y
authors.initials: Y
authors.lastname: Chalem
authors.forename: S
authors.initials: S
authors.lastname: El Metaoua
authors.forename: E
authors.initials: E
authors.lastname: Rondeau
authors.forename: P
authors.initials: P
authors.lastname: Tuppin
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
mesh_terms: D017677:Age Distribution; D002102:Cadaver; D003287:Contrast Media / Q000494:pharmacology*; D016208:Databases, Factual; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D006084:Graft Rejection / Q000401:mortality; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology / Q000706:statistics & numerical data*; D008297:Male; D015999:Multivariate Analysis; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D013997:Time Factors; D009927:Tissue and Organ Procurement; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media