title: Efficacy of a herbal toothpaste on patients with established gingivitis--a randomized controlled trial.
abstract: The aim of this randomised, double blind controlled trial was to verify the efficacy of a herbal dentifrice on the reduction of plaque and gingivitis. Forty eight volunteers with established gingivitis were randomly assigned to either a test group (herbal dentifrice) or positive control group (dentifrice with triclosan and fluoride). The dentifrices were distributed in plain white tubes by an independent pharmacy, which revealed the contents of each tube only after the experimental period. Plaque and gingivitis assessments were carried out on baseline and after 28 days of product use. All examinations were conducted by the same calibrated investigator. Subjects were instructed to brush their teeth three times daily using their assigned dentifrice for 28 days. There was a significant reduction in plaque levels in both the test and control groups. However, there was no significant difference between the groups. A significant reduction in gingivitis was observed in both groups, although there was no significant difference between them. No adverse reactions were reported. The authors concluded that both dentifrices were effective in reducing plaque and gingivitis in subjects with established gingivitis.
authors.affiliation: School of Dentistry, Ibirapuera University.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Ozaki
authors.forename: Claudio Mendes
authors.initials: CM
authors.lastname: Pannuti
authors.forename: Ana Vitória
authors.initials: AV
authors.lastname: Imbronito
authors.forename: Wellington
authors.initials: W
authors.lastname: Pessotti
authors.forename: Luciana
authors.initials: L
authors.lastname: Saraiva
authors.forename: Nívea Maria
authors.initials: NM
authors.lastname: de Freitas
authors.forename: Graziella
authors.initials: G
authors.lastname: Ferrari
authors.forename: Veronica Neto
authors.initials: VN
authors.lastname: Cabral
mesh_terms: D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D003773:Dental Plaque / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D014100:Toothpastes / Q000592:standards / Q000627:therapeutic use*; D014260:Triclosan / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D014100:Toothpastes; D014260:Triclosan; D017693:Sodium Bicarbonate; D012969:Sodium Fluoride