Analysis of population differentiation in North Eurasian cattle (Bos taurus) using single nucleotide polymorphisms in three genes associated with production traits.
Single nucleotide polymorphisms (SNPs) in growth hormone 1 (GH1), insulin-like growth factor 1 (IGF1) and leptin (LEP), all candidates for production traits in cattle, were characterized in North Eurasian cattle breeds. Allele frequencies of IGF1 exhibited significant (P < 0.05) deviation from neutral expectation and therefore, might be associated with divergence in North Eurasian cattle because of genetic selection. Allele frequencies and lower heterozygosity of LEP may indicate a recent introduction of an alternative allele in this geographic region. Locus F(ST) estimates were highest for IGF1 (0.151, sigma = 0.042) and lowest for GH (0.062, sigma = 0.020). Our results suggest a slightly higher population differentiation across the candidate genes (FST = 0.108) than across microsatellites (FST = 0.095), possibly because of selection and stochastic effects.
Li
M H
MH
Biotechnology and Food Research, MTT Agrifood Research Finland, FIN-31600 Jokioinen, Finland.
Adamowicz
T
T
Switonski
M
M
Ammosov
I
I
Ivanova
Z
Z
Kiselyova
T
T
Popov
R
R
Kantanen
J
J
D000818:Animals; D001208:Asia; D002417:Cattle / Q000145:classification / Q000235:genetics*; D005060:Europe; D005787:Gene Frequency; D005796:Genes; D013006:Growth Hormone / Q000235:genetics*; D006579:Heterozygote; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D020738:Leptin / Q000235:genetics*; D018895:Microsatellite Repeats; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci
D020738:Leptin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone