title: Tumour markers in chronic heart failure. Review of the literature and clinical implications.
abstract: Over the last years a growing interest for the biochemical abnormalities detectable in heart failure has become evident. In particular, large scientific evidence has been provided on hormones (catecholamines, renin-angiotensin-aldosterone system, natriuretic peptides) and cytokines (tumour necrosis factor, interleukins, etc.). Quite recently the attention of clinicians and researchers has also been directed towards high serum levels of tumour markers in this syndrome. Carbohydrate antigen 125 has been observed to increase in patients with congestive heart failure, to correlate with haemodynamic and clinical parameters of severity, and to show significant changes after adequate treatment. The aim of this paper is to review the data currently available on serum levels of tumour markers in patients with chronic heart failure, focusing the attention on the potential clinical use of carbohydrate antigen 125.
authors.affiliation: Division of Cardiology, University of Brescia, Italy. faggiano@numerica.it
authors.forename: Pompilio
authors.initials: P
authors.lastname: Faggiano
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Aloia
authors.forename: Francesco
authors.initials: F
authors.lastname: Antonini-Canterin
authors.forename: Enrico
authors.initials: E
authors.lastname: Vizzardi
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Nicolosi
authors.forename: Livio Dei
authors.initials: LD
authors.lastname: Cas
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D002908:Chronic Disease; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen