title: Relationship of five inflammatory gene polymorphisms with morbidity and mortality in 533 patients admitted to an ICU.
abstract: BACKGROUND
  The aim of this study was to analyze the association of polymorphisms of five candidate genes with the outcome of consecutive patients admitted to a medical ICU.
  
  
  METHODS
  The study population was prospectively recruited. Inclusion criteria were admission to the ICU and written informed consent by the patients or their relatives. A total of 533 patients were recruited. The morbidity was assessed by SAPS II Score. Outcome data of in hospital mortality and length of ICU and hospital stay were obtained. Genotyping for genetic polymorphisms (CRP 1059, IL1B -511, CTGF -477, CCR2 64VI, IL6 -174) were performed by allele-specific fluorogenic oligonucleotide probes (TaqMan analysis).
  
  
  RESULTS
  All of the investigated polymorphisms were not associated with an altered outcome. There was no difference in morbidity and ICU or in-hospital mortality (neither in cross tabs analysis nor in Kaplan Meier or Cox regression analysis including age, gender and diagnosis as covariates) between the different genotypes.
  
  
  CONCLUSIONS
  Genotyping of the investigated polymorphism for risk stratification of patients admitted to ICU does not seem to be appropriated.
authors.affiliation: Interdisciplinary Intermediate Care, University Hospital of Aachen-RTWTH, Pauwelsstrasse 30, 52057 Aachen, Germany.
authors.forename: Jan R
authors.initials: JR
authors.lastname: Ortlepp
authors.forename: Jürgen
authors.initials: J
authors.lastname: Graf
authors.forename: Katharina
authors.initials: K
authors.lastname: Vesper
authors.forename: Fabian
authors.initials: F
authors.lastname: Schmitz
authors.forename: Vera
authors.initials: V
authors.lastname: Mevissen
authors.forename: Sebastian
authors.initials: S
authors.lastname: Sucigan
authors.forename: Alexander
authors.initials: A
authors.lastname: Kersten
authors.forename: Christian
authors.initials: C
authors.lastname: Weber
authors.forename: Uwe
authors.initials: U
authors.lastname: Janssens
mesh_terms: D000368:Aged; D000483:Alleles; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D016207:Cytokines