title: A born-type approximation method for bioluminescence tomography.
abstract: In this paper, we present a Born-type approximation method for bioluminescence tomography (BLT), which is to reconstruct an internal bioluminescent source from the measured bioluminescent signal on the external surface of a small animal. Based on the diffusion approximation for the photon propagation in biological tissue, this BLT method utilizes the Green function to establish a linear relationship between the measured bioluminescent signal and the internal bioluminescent source distribution. The Green function can be modified to describe a heterogeneous medium with an arbitrary boundary using the Born approximation. The BLT reconstruction is formulated in a linear least-squares optimization framework with simple bounds constraint. The performance of this method is evaluated in numerical simulation and phantom experiments.
authors.affiliation: Bioluminescence Tomography Laboratory, Department of Radiology, University of Iowa, Iowa City, Iowa 52242, USA. cong@ct.radiology.uiowa.edu
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Cong
authors.forename: Kumar
authors.initials: K
authors.lastname: Durairaj
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004058:Diffusion; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016018:Least-Squares Analysis; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*