title: The effect of whole organ pancreas transplantation and PIT on diabetic complications.
abstract: Diabetes mellitus is a leading cause of morbidity and mortality in the Western world. Currently, the only forms of beta-cell replacement are whole organ pancreas transplantation and pancreatic islet transplantation. Whole organ transplantation has demonstrated benefits in prevention and reversal of diabetic complications with sustainable long-term outcomes. Pancreatic islet transplantation continues to be a field that needs further study to ascertain the true benefit of islet transplantation for diabetic complications. This can only be achieved with improvement in long-term islet allograft survival.
authors.affiliation: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Lee
authors.forename: Neal R
authors.initials: NR
authors.lastname: Barshes
authors.forename: Erin E
authors.initials: EE
authors.lastname: Agee
authors.forename: Christine A
authors.initials: CA
authors.lastname: O'Mahoney
authors.forename: F Charles
authors.initials: FC
authors.lastname: Brunicardi
authors.forename: John A
authors.initials: JA
authors.lastname: Goss
mesh_terms: D048909:Diabetes Complications / Q000503:physiopathology / Q000601:surgery*; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003925:Diabetic Angiopathies / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000503:physiopathology; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D016035:Pancreas Transplantation / Q000379:methods*; D016896:Treatment Outcome