title: H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation.
abstract: The mechanism of apoptotic signaling by JNK is incompletely understood. In the July 7 issue of Molecular Cell, Lu et al. (2006) report that JNK phosphorylation of H2AX at a noncanonical site is required for caspase-induced DNA fragmentation.
authors.affiliation: Department of Cancer Cell Biology and University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
authors.forename: Hayla K
authors.initials: HK
authors.lastname: Sluss
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Davis
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D053938:DNA Fragmentation; D006657:Histones / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C468783:H2AX protein, human; D006657:Histones; D048031:JNK Mitogen-Activated Protein Kinases