[The expression of GFAP after brain concussion in rats].
OBJECTIVE
To study the expression of GFAP and pathologic changes after rats brain concussion, so that to provide evidence on brain concussion for forensic identification.


METHODS
Forty-five SD rats were divided into 3, 6, 12, 24 h and 2, 4, 7, 10 d and normal control groups in terms of different wounding time after brain concussion model established, and the expression of GFAP after rats brain concussion were then observed by using SP immunohistochemical method.


RESULTS
In normal control brain, low-level GFAP expressions could be observed. After six hours' brain concussion, GFAP positive cells increased obviously. The trend reached to the peak at 7d, partly declined at 10d, then decreased gradually.


CONCLUSIONS
Brain concussion induced the expression of GFAP. The detection of GFAP could be useful for diagnosis of brain concussion on forensic pathology, and could be a reference index for timing of injury after brain concussion.
Zhang
Chun-Bing
CB
Department of Forensic Medicine, Wannan Medical College, Wuhu 241001, China.
Li
Yong-Hong
YH
D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology*; D001924:Brain Concussion / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D049429:Forensic Pathology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D005904:Glial Fibrillary Acidic Protein