Optimal probing of optical contrast of breast lesions of different size located at different depths by US localization.
We report a frequency domain optical tomography system utilizing three RF modulation frequencies, which are optimized for probing breast lesions of different size located at different depths. A real-time co-registered ultrasound scanner is used to provide on-site estimation of lesion size and location. Based on the lesion information, an optimal light modulation frequency can be selected, which may yield more accurate estimates of lesion angiogenesis and hypoxia. Phantom experiments have demonstrated that a high modulation frequency, such as 350Mhz, is preferable for probing small lesions closer to the surface while a low modulation frequency, such as 50Mhz, is desirable for imaging deeper and larger lesions. A clinical example of a large invasive carcinoma is presented to demonstrate the application of this novel technique.
Zhu
Quing
Q
Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd., Storrs, CT 06269, USA. zhu@engr.uconn.edu
Xu
Chen
C
Guo
Puyun
P
Aguirre
Andres
A
Yuan
Baohong
B
Huang
Fei
F
Castilo
Diego
D
Gamelin
John
J
Tannenbaum
Susan
S
Kane
Mark
M
Hegde
Poornima
P
Kurtzman
Scott
S
D000465:Algorithms; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology*; D004867:Equipment Design; D005260:Female; D006801:Humans; D000860:Hypoxia; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008875:Middle Aged; D015233:Models, Statistical; D009389:Neovascularization, Pathologic; D019047:Phantoms, Imaging; D012984:Software; D014463:Ultrasonography / Q000379:methods*