title: A case report of Clarkson's disease: If you don't know it, you'll miss it.
abstract: The systemic capillary leak syndrome (SCLS), also known as Clarkson's disease, is a rare disorder characterized by paroxysmal capillary hyperpermeability with a shift of plasma fluid from the intravascular to the interstitial space. A 35-year-old previously healthy woman was admitted with rapidly developing hypovolemic shock syndrome, rhabdomyolysis, and diffuse edema. Laboratory analysis revealed a severe hemoconcentration, renal insufficiency, and paraproteinemia. After exclusion of infection, allergy, burning or drug-induced conditions, the clinical presentation was consistent with the diagnosis of SCLS. Though this is a rare entity, the substantial morbidity and mortality associated with it necessitate the physician's awareness in order to provide timely therapy. This report is meant to enhance awareness of SCLS.
authors.affiliation: Department of Internal Medicine, University Hospital Bern, 3010 Bern, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bonadies
authors.forename: Patricia
authors.initials: P
authors.lastname: Baud
authors.forename: Hans-Jakob
authors.initials: HJ
authors.lastname: Peter
authors.forename: Ulrich
authors.initials: U
authors.lastname: Buergi
authors.forename: Beatrice U
authors.initials: BU
authors.lastname: Mueller