title: Hypotonic stress enhances slope conductivity of ATP-sensitive K+ channels activated pharmacologically.
abstract: The aim of this paper was to find out the effects of hypotonic stress on the slope conductivity of ATP-sensitive K(+) channels. Using patch clamp technique, rilmakalim and pinacidil as the activators and glibenclamide as an inhibitor of mentioned channels, we have demonstrated that short hypotonic challenge doubled slope conductivity of exploring channels by augmentation of their open probability.
authors.forename: Ivan
authors.initials: I
authors.lastname: Kocić
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirano
authors.forename: Jacek
authors.initials: J
authors.lastname: Petrusewicz
authors.forename: Masayasu
authors.initials: M
authors.lastname: Hiraoka
mesh_terms: D000255:Adenosine Triphosphate; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002839:Chromans / Q000494:pharmacology; D005260:Female; D005905:Glyburide / Q000494:pharmacology; D006168:Guinea Pigs; D007038:Hypotonic Solutions / Q000494:pharmacology*; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000502:physiology; D020110:Pinacidil / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D002839:Chromans; D007038:Hypotonic Solutions; D015221:Potassium Channels; D011759:Pyrrolidines; C075012:rilmakalim; D020110:Pinacidil; D000255:Adenosine Triphosphate; D005905:Glyburide