title: A case of suspected lymphocytic hypophysitis and organizing pneumonia during maintenance therapy for autoimmune pancreatitis associated with autoimmune thrombocytopenia.
abstract: A 75-year-old man with a medical history of autoimmune pancreatitis associated with autoimmune thrombocytopenia was emergently admitted to our hospital because of anorexia, vomiting, and transient loss of consciousness. Serum sodium was 115 mEq/l and the endocrinologic data indicated impaired secretion of ACTH, TSH, and gonadotropin, a preserved GH response, and increased PRL. Dynamic magnetic resonance imaging revealed marked swelling of the pituitary gland and stalk, with enhancement on early phase. The findings were consistent with lymphocytic hypophysitis according to the diagnostic criteria. Chest computed tomography revealed consolidation adjacent to the pleura in the right upper lobe, lower lobe, and left lower lobe. Because lymphocytic hypophysitis and associated organizing pneumonia were suggested, 50 mg of prednisolone was started and the dose was tapered. Swelling of the pituitary gland, lung lesion, and the LH and FSH response on the stimulation test were all markedly improved. Autoimmune pancreatitis, pituitary lesion, and organizing pneumonia might all be components of a systemic autoimmune fibrosclerosing disease in our case, although further studies are required to confirm this hypothesis.
authors.affiliation: Department of Internal Medicine, Otsu Red Cross Hospital, Otsu, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hamasaki
authors.forename: Motozumi
authors.initials: M
authors.lastname: Okamoto
mesh_terms: D000368:Aged; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D050500:Pancreatitis, Chronic / Q000150:complications* / Q000188:drug therapy; D010900:Pituitary Diseases / Q000150:complications* / Q000175:diagnosis; D011014:Pneumonia / Q000150:complications* / Q000175:diagnosis; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000188:drug therapy
chemical_list: D011239:Prednisolone