title: Impact--the cone and plate(let) analyzer: testing platelet function and anti-platelet drug response.
abstract: The Impact [cone and plate(let) analyzer (CPA) Technology]is testing whole blood platelet adhesion and aggregation under arterial flow conditions. The adhered platelets are stained and the percentage of surface covered (SC) by the stained objects and the average size (AS) of the objects are determined by image analyzer. The system allows screening of congenital primary hemostasis abnormalities, including adhesion as well as aggregation defects. The observation that exposure of blood to suboptimal concentrations of platelet agonists for 1 min prior to the Impact test causes platelet adhesion refractoriness led to the development of Impact aggregation tests and of specific tests for the determination of platelet response to aspirin and clopidogrel.
authors.affiliation: Goldschleger Eye Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Naphtali
authors.initials: N
authors.lastname: Savion
authors.forename: David
authors.initials: D
authors.lastname: Varon
mesh_terms: D001791:Blood Platelet Disorders / Q000175:diagnosis; D019411:Clinical Laboratory Techniques; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010979:Platelet Function Tests / Q000295:instrumentation / Q000379:methods*
chemical_list: D010975:Platelet Aggregation Inhibitors