Migratory dendritic cells: sometimes simply ferries?
In this issue, Allan et al. (2006) conclude that transport of herpes-virus antigens to lymph nodes by dendritic cells is crucial for antiviral immunity, but migrating DCs do not present herpes antigens to CD8(+) lymphocytes.
Randolph
Gwendalyn J
GJ
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D006561:Herpes Simplex / Q000276:immunology / Q000821:virology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology