title: Chemokines and pain.
abstract: Chemokines are chemotactic mediators controlling cell trafficking under physiological and pathological conditions. Recently, it has been discovered that chemokines are not only important in various inflammatory conditions, but that they also play a role in pain and analgesia. Chemokine function in the periphery has been evaluated under non-inflammatory, inflammatory and neuropathic conditions. While many studies have examined the hyperalgesic action of chemokines, increasing evidence points to the antinociceptive properties of chemokines. This review focuses on the role of chemokines in the peripheral tissue.
authors.affiliation: Klinik für Anästhesiologie und Operative Intensivmedizin, Charité-Universitätsmedizin Berlin, Germany. heike.rittner@charite.de
authors.forename: Heike L
authors.initials: HL
authors.lastname: Rittner
authors.forename: Alexander
authors.initials: A
authors.lastname: Brack
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D018925:Chemokines / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology; D010146:Pain / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000150:complications
chemical_list: D000700:Analgesics; D018925:Chemokines