Genetic variants and the risk of Crohn's disease: what does it mean for future disease management?
Genetic research in inflammatory bowel disease, especially in Crohn's disease, has made significant progress during recent years. There have been > 10 total genome scans that have been performed, and susceptibility loci on several chromosomes have been identified. Together with candidate gene studies, these scans have led to the identification of several susceptibility genes, with CARD15 being the most important. These genetic data have already provided important insights into the pathophysiology of inflammatory bowel disease and are stimulating future research. On the other hand, genotype-phenotype associations have illustrated the heterogenic nature of the disease. Although the clinical application of this knowledge is so far limited, there is significant optimism that an individual management of patients based on genetic data will be possible in the near future.
Török
Helga-Paula
HP
Department of Surgery Innenstadt, Ludwig-Maximilians University, Nussbaumstrasse 20, D-80336 Munich, Germany. Helga.Toeroek@med.uni-muenchen.de
Glas
Jürgen
J
Lohse
Peter
P
Folwaczny
Christian
C
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002986:Clinical Trials as Topic; D003424:Crohn Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D015122:Mercaptopurine / Q000031:analogs & derivatives / Q000627:therapeutic use; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D010548:Personal Health Services / Q000639:trends*; D010597:Pharmacogenetics / Q000639:trends*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
D048868:Adaptor Proteins, Signal Transducing; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D047908:Intracellular Signaling Peptides and Proteins; C119067:NOD1 protein, human; C429018:NOD2 protein, human; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; C488629:azathiopurine; D015122:Mercaptopurine