title: A new entry to polycyclic indole skeletons via palladium-catalyzed intramolecular heteroannulation.
abstract: [reaction: see text] A one-step method was developed for elaboration of a variety of polycyclic indole skeletons via a novel palladium-catalyzed intramolecular indolization of 2-chloroanilines bearing tethered acetylenes. This novel intramolecular indolization method unveils an unusual syn amidopalladation pathway of a tethered alkyne.
authors.affiliation: Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., 800 East Leigh Street, Suite 205, Richmond, Virginia 23219, USA.
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.forename: Yongda
authors.initials: Y
authors.lastname: Zhang
authors.forename: Guisheng
authors.initials: G
authors.lastname: Li
authors.forename: Ahmad
authors.initials: A
authors.lastname: Khodabocus
authors.forename: Sonia
authors.initials: S
authors.lastname: Rodriguez
authors.forename: Bo
authors.initials: B
authors.lastname: Qu
authors.forename: Vittorio
authors.initials: V
authors.lastname: Farina
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Lu
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D026121:Indole Alkaloids; D010165:Palladium