title: Hemisynthesis of new labdane derivatives from (-)-sclareol.
abstract: A straightforward and very simple access to different analogues of (+)-subersic acid 7, the unnatural enantiomer (compounds 12) from naturally occurring (-)-sclareol 1 is described. We also report new conditions for the preparation of keto-intermediate 8 using maleic acid and describe hemiketal 11 as the new intermediate of degradative oxidation of 1.
authors.affiliation: Laboratoire de Chimie, Département des Sciences Fondamentales et Mixtes, Faculté de Médecine Dentaire, 5000 Monastir, Tunisia. fekihus@yahoo.com
authors.forename: Abdel Waheb
authors.initials: AW
authors.lastname: Fekih
authors.forename: Karima
authors.initials: K
authors.lastname: Gafsi
authors.forename: Letitia
authors.initials: L
authors.lastname: Ferreiro-Mederos
authors.forename: Gilles
authors.initials: G
authors.lastname: Hanquet
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry*; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004224:Diterpenes; D013729:Terpenes; C497305:subersic acid; C070760:sclareol