Role of coagulation factor XIII (FXIII) in angiogenesis and tissue repair.
Factor FXIII (FXIII) is a plasma transglutaminase that catalyzes the cross link formation between fibrin chains to stabilize the clot. Beside it s function in hemostasis FXIII has a role in wound healing and embryo implantation--processes that involve angiogenesis. In this review we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its pro-angiogenic effect. In addition, FXIII role in wound repair is discussed.
Inbal
Aida
A
Institute of Thrombosis, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Israel. AIDAINBAL@HOTMAIL.COM
Dardik
Rima
R
D005176:Factor XIII / Q000502:physiology*; D005177:Factor XIII Deficiency; D006706:Homeostasis; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
D005176:Factor XIII