title: Bioactive coatings based on polyelectrolyte multilayer architectures functionalized by embedded proteins, peptides or drugs.
abstract: In recent years, considerable effort has been devoted to the design and controlled fabrication of structured materials with functional properties. The layer by layer buildup of polyelectrolyte multilayer films (PEM films) from oppositely charged polyelectrolytes offers new opportunities for the preparation of functionalized biomaterial coatings. This technique allows the preparation of supramolecular nano-architectures exhibiting specific properties in terms of control of cell activation and may also play a role in the development of local drug delivery systems. Peptides, proteins, chemically bound to polyelectrolytes, adsorbed or embedded in PEM films, have been shown to retain their biological activities.
authors.affiliation: INSERM Unité 595, Université Louis Pasteur, 11 Rue Humann, F-67085 Strasbourg Cedex, France.
authors.forename: Erell
authors.initials: E
authors.lastname: Leguen
authors.forename: Armelle
authors.initials: A
authors.lastname: Chassepot
authors.forename: Gero
authors.initials: G
authors.lastname: Decher
authors.forename: Pierre
authors.initials: P
authors.lastname: Schaaf
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Voegel
authors.forename: Nadia
authors.initials: N
authors.lastname: Jessel
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D004573:Electrolytes; D010455:Peptides; D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; D011506:Proteins