title: Association of a wide invasive malignant thymoma with myastenia gravis and primary hyperparathyroidism due to parathyroid adenoma: case report and review of the literature.
abstract: There are few cases described in the world literature reporting an association of thymoma (with myasthenia gravis or not) with hyperparathyroidism. In these cases the hyperparathyroidism was due to the presence of an adenoma or hyperplasic parathyroid tissue either in the cervical region or in an ectopic intrathymic location.(12345) In other cases the syndrome of hypercalcemia was due to the secretion of parathyroid-related protein (PTHRP) (6) or parathyroid hormone (PTH) (7) by the thymoma itself. We report the first case, at the best of our knowledge, of a wide invasive malignant thymoma (type B3), associated with myasthenia gravis and hyperparathyroidism caused by parathyroid adenoma.
authors.affiliation: Endocrinology and Metabolic Diseases, Department of Application of Innovative Technology in Surgery, University of Bari, Bari, Italy. v.triggiani@endo.uniba.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Triggiani
authors.forename: Edoardo
authors.initials: E
authors.lastname: Guastamacchia
authors.forename: Ivan
authors.initials: I
authors.lastname: Lolli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Troccoli
authors.forename: Francesco
authors.initials: F
authors.lastname: Resta
authors.forename: Carlo
authors.initials: C
authors.lastname: Sabbà
authors.forename: Nadia
authors.initials: N
authors.lastname: Ruggieri
authors.forename: Emilio
authors.initials: E
authors.lastname: Tafaro
mesh_terms: D000236:Adenoma / Q000150:complications / Q000473:pathology*; D000971:Antineoplastic Combined Chemotherapy Protocols; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D010282:Parathyroid Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D013953:Thymus Neoplasms / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D016896:Treatment Outcome