title: Ultra-sensitive and quantitative characterization of proteomes.
abstract: Electrospray ionization mass spectrometry combined with high efficiency capillary liquid chromatography provides high sensitivity and broad dynamic range measurements for the characterization of biological macromolecules in complex matrices, and is an increasingly powerful analytical tool for systems biology research.
authors.affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, MS K8-98, Richland, WA 99352, USA. rds@pnl.gov
authors.forename: Richard D
authors.initials: RD
authors.lastname: Smith
authors.forename: Keqi
authors.initials: K
authors.lastname: Tang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008954:Models, Biological; D040901:Proteomics / Q000379:methods*; D020592:Shewanella / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods