title: Secondary cutaneous effects of hydroxyurea: possible pathogenetic mechanisms.
abstract: We report the case of a 73-year-old man who had been on hydroxyurea for essential thrombocythemia since 1988. After 12 years of treatment he developed a symmetrical dermatomyositis-like eruption together with a leg ulceration and five squamous cell carcinomas of the face. The possible pathogenetic mechanisms of these known side effects are discussed.
authors.affiliation: Di.S.E.M. Department of Endocrinological and Metabolic Science, Section of Dermatology, University of Genoa, Genoa, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Zaccaria
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cozzani
authors.forename: Aurora
authors.initials: A
authors.lastname: Parodi
mesh_terms: D000368:Aged; D001132:Arm / Q000473:pathology; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007871:Leg Ulcer / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000188:drug therapy*
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D006918:Hydroxyurea