title: Urodynamic parameters and plasma LH/FSH in spayed Beagle bitches before and 8 weeks after GnRH depot analogue treatment.
abstract: The pathophysiology of urinary incontinence due to spaying remains unknown. Incontinent bitches can be treated successfully with depot preparations of GnRH-analogues and there are differences in plasma gonadotropin levels between continent and incontinent spayed bitches. It is therefore assumed that the supraordinated hormones, GnRH, FSH, and/or LH, have an effect on the urodynamic parameters. In this study, the potential influence of these hormones on the lower urinary tract was investigated by measuring urethral pressure profiles and cystometry. Simultaneously, plasma concentrations in 10 spayed Beagle bitches were determined 5 weeks prior to and 8 weeks after treatment with the GnRH analogue leuprolide. Within 1 week of GnRH analogue administration, plasma FSH and LH levels decreased from 72.5 and 7.7 to 7.75 and 0.72ng/mL, respectively. These plasma gonadotropin levels correspond with those of intact bitches during anoestrus. Urethral pressure profiles indicated that the treatment had no significant effect on maximum urethral closure pressure, functional and total length of the urethra, or area of the closure pressure curve. The data obtained by cystometry regarding mean bladder threshold volume showed a significant increase from 109 to 172mL. The improvement in bladder function after the application of GnRH-application is presumably a direct effect of the GnRH as a relationship between the plasma gonadotropin levels and the urodynamic parameters could not demonstrated.
authors.affiliation: Section of Small Animal Reproduction, Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 260, 8057 Zurich, Switzerland. ireichler@vetclinics.unizh.ch
authors.forename: Iris Margaret
authors.initials: IM
authors.lastname: Reichler
authors.forename: Andrea
authors.initials: A
authors.lastname: Barth
authors.forename: Claude A
authors.initials: CA
authors.lastname: Piché
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Jöchle
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Roos
authors.forename: Madeleine
authors.initials: M
authors.lastname: Hubler
authors.forename: Susi
authors.initials: S
authors.lastname: Arnold
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D004285:Dogs / Q000097:blood / Q000502:physiology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*; D016729:Leuprolide / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood; D010052:Ovariectomy / Q000009:adverse effects / Q000662:veterinary; D011312:Pressure; D014521:Urethra / Q000502:physiology*; D014549:Urinary Incontinence / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide