The effect of PEG concentration on the release rate of cisplatin from PEG-modified silica xerogels.
Cisplatin-an antineoplastic medicine-was incorporated into a polyethylene glycol (PEG)-modified silica xerogels received by the sol-gel method. The influence of PEG concentration and drying temperature on the release of cisplatin was studied. From our results we may state that addition of PEG (MW 600) and drying of silica xerogels at 80 degrees C augmented the release of cisplatin. The release of cisplatin from the matrices grows with the increase of PEG volume in xerogel (up to 74-97% within 7 days), whereas application of thermal drying resulted in both increased speed and amount of the drug released up to 91-97% within 2 days.
Czarnobaj
Katarzyna
K
Department of Physical Chemistry with Laboratory of Instrumental Analysis, Medical University of Gdańsk, al. Gen. J. Hallera 107, Gdańsk, 80-416, Poland. kczar@biology.pl
Prokopowicz
Magdalena
M
Lukasiak
Jerzy
J
D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics; D002945:Cisplatin / Q000737:chemistry / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D005782:Gels; D011092:Polyethylene Glycols / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D013997:Time Factors
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D005782:Gels; D012821:Silanes; D011092:Polyethylene Glycols; C040733:tetraethoxysilane; D012822:Silicon Dioxide; D002945:Cisplatin