title: Iodine intake in pregnancy in Ireland--a cause for concern?
abstract: BACKGROUND
  Adequate dietary iodine intake is necessary to maintain maternal thyroid function at a level permitting normal neuropsychological development of the foetus.
  
  
  OBJECTIVE
  To determine dietary iodine status by measuring urinary iodine excretion (UIE), proportional to dietary intake, in Irish mothers during the first trimester of pregnancy.
  
  
  RESULTS
  Median UIE showed seasonal variations, being lower in summer than in winter. The median values in pregnant women were, summer 45microg/l, winter 68microg/l. Equivalent values for controls were 43 and 91microg/l respectively. UIE required to achieve WHO recommended daily iodine intakes would be 120-180microg/l. In the Irish subjects UIE values suggestive of iodine deficiency (<50microg/l) were observed in 55% of pregnant women tested in summer and 23% in winter. Dairy milk iodine, a major dietary iodine source, showed similar variation.
  
  
  CONCLUSIONS
  While there is as yet no available evidence of widespread thyroid hypofunction in the Irish obstetric population, the findings are a cause of concern, which if confirmed by a more comprehensive investigation, may indicate the need for iodine prophylaxis.
authors.affiliation: UCD School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin and National Maternity Hospital.
authors.forename: Z
authors.initials: Z
authors.lastname: Nawoor
authors.forename: R
authors.initials: R
authors.lastname: Burns
authors.forename: D F
authors.initials: DF
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Sheehan
authors.forename: C
authors.initials: C
authors.lastname: O'Herlihy
authors.forename: P P A
authors.initials: PP
authors.lastname: Smyth
mesh_terms: D000328:Adult; D000818:Animals; D004032:Diet; D005260:Female; D006801:Humans; D007455:Iodine / Q000652:urine*; D007494:Ireland / Q000453:epidemiology; D008892:Milk; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000652:urine; D012621:Seasons; D013961:Thyroid Gland / Q000196:embryology*
chemical_list: D007455:Iodine