[Evaluation of the antihypoxic activity of glycine and its phosphorylated derivative].
The antihypoxant activity of glycine and its phosphorilated derivative AKF 90-7 in doses 1, 20, 50 and 100 mg/kg was studied. AKF 90-7 increases the survival of laboratory animals under the conditions of various hypoxia types. The antihypoxic effect of glycine was the same with the effect of AKF 90-7 in hystotoxic hypoxia, but absent on the model of hemic hypoxia and substantially lower than that of AKF 90-7 on the models of hypercapnic and hypobaric hypoxia.
Makarova
L M
LM
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005998:Glycine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D008808:Mice, Inbred CBA
D000975:Antioxidants; D005998:Glycine