title: Effects of short-term and subchronic lead poisoning on nitric oxide metabolites and vascular responsiveness in rat.
abstract: Chronic exposure to low levels of lead results in sustained hypertension in humans and experimental animals. The mechanism of lead-induced hypertension remains unclear. We investigated the short-term (4 and 8 weeks) and subchronic (12 weeks) effects of lead treatment on responsiveness of vascular adrenergic system and level of nitric oxide metabolites, that is, total nitrates and nitrites (NOx). Male Sprague-Dawley rats were treated with lead acetate (100 ppm in drinking water) for 12 weeks. Short-term lead administration resulted in marked elevation of blood pressure accompanied by significant reduction in serum NOx levels. In contrast, after subchronic lead administration the trend of decrease in NOx levels somehow reversed despite further increase in blood pressure. Both short-term and subchronic lead administration resulted in significant differences in vascular reactivity with respect to either vasoconstrictor (phenylephrine and clonidine) or vasodilator (isoproterenol) agents. We conclude that vascular adrenergic system and nitric oxide pathway change in short-term and subchronic phases of lead poisoning.
authors.affiliation: Department of Physiology and Biophysics, Baghyatollah University of Medical Sciences, Tehran, Iran. a1361h@yahoo.com
authors.forename: Azhdar
authors.initials: A
authors.lastname: Heydari
authors.forename: Ali
authors.initials: A
authors.lastname: Norouzzadeh
authors.forename: Ali
authors.initials: A
authors.lastname: Khoshbaten
authors.forename: Alireza
authors.initials: A
authors.lastname: Asgari
authors.forename: Asghar
authors.initials: A
authors.lastname: Ghasemi
authors.forename: Soheil
authors.initials: S
authors.lastname: Najafi
authors.forename: Reza
authors.initials: R
authors.lastname: Badalzadeh
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D007855:Lead Poisoning / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009566:Nitrates / Q000097:blood / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000097:blood / Q000378:metabolism; D009942:Organometallic Compounds / Q000097:blood / Q000506:poisoning; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D009566:Nitrates; D009573:Nitrites; D009942:Organometallic Compounds; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D009569:Nitric Oxide; C008261:lead acetate