title: Foxp3+ regulatory T cells in antiretroviral-naive HIV patients.
abstract: We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/microl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.
authors.affiliation: Department of Medicine, Texas, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Montes
authors.forename: Dorothy E
authors.initials: DE
authors.lastname: Lewis
authors.forename: Cesar
authors.initials: C
authors.lastname: Sanchez
authors.forename: Diego
authors.initials: D
authors.lastname: Lopez de Castilla
authors.forename: Edward A
authors.initials: EA
authors.lastname: Graviss
authors.forename: Carlos
authors.initials: C
authors.lastname: Seas
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gotuzzo
authors.forename: A Clinton
authors.initials: AC
authors.lastname: White
mesh_terms: D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D051858:Forkhead Transcription Factors / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors