Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers.
This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
Lee
Jae Yeol
JY
Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Seoul 130-701, Republic of Korea. ljy@khu.ac.kr
Park
Seong Jun
SJ
Park
Sung Jun
SJ
Lee
Min Joo
MJ
Rhim
Hyewhon
H
Seo
Seon Hee
SH
Kim
Ki-Sun
KS
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D020747:Calcium Channels, T-Type; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002121:Calcium Channel Blockers; D020747:Calcium Channels, T-Type; D002118:Calcium