Unique features of a highly pathogenic Campylobacter jejuni strain.
Campylobacter jejuni, a major human enteric pathogen, exhibits significant strain-to-strain differences which result in differences in pathogenic potential. C. jejuni 81-176 is a highly virulent strain that exhibits unique pathogenic features and is used by many research laboratories. We have determined the nucleotide sequence of its genome and compared it to the genomes of other sequenced C. jejuni strains. We identified a number of unique genetic features which may confer specific metabolic and pathogenic properties on this strain. We have also identified regions of the C. jejuni genome that are hot spots for the integration of horizontally acquired genetic material. This information should help the understanding of the pathogenesis of C. jejuni and, in particular, the unique features of this highly pathogenic strain.
Hofreuter
Dirk
D
Section of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, Connecticut 06536, USA.
Tsai
Jennifer
J
Watson
Robert O
RO
Novik
Veronica
V
Altman
Bill
B
Benitez
Michelle
M
Clark
Christina
C
Perbost
Clotilde
C
Jarvie
Thomas
T
Du
Lei
L
Galán
Jorge E
JE
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D002169:Campylobacter Infections / Q000382:microbiology*; D016123:Campylobacter jejuni / Q000145:classification* / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D002460:Cell Line; D004269:DNA, Bacterial / Q000032:analysis; D004847:Epithelial Cells / Q000382:microbiology; D016680:Genome, Bacterial; D006801:Humans; D007422:Intestines / Q000166:cytology; D051379:Mice; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D014774:Virulence
D001426:Bacterial Proteins; D004269:DNA, Bacterial