The use of particle counting immunoassay for the diagnosis of neurological disease.
Particle counting immunoassay (PACIA) is applied to the determination of proteins at trace levels in normal and pathological cerebrospinal fluid (CSF) samples. Performance characteristics for the assays are given and the results for immunoglobulins (Igs) expressed as Ig indices. Ig profiles characteristic of various neurological disorders have been studied, and anti-herpes antibodies detected using an agglutination inhibition method. Ferritin, C-reactive protein and the brain protein S-100 have also been studied.
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Unit of Experimental Medicine, I.C.P.-U.C.L., and Laboratory of Neurochemistry, U.C.L., 53, Avenue Mounier, 1200 Brussels, Belgium.