Killing kinetics of caspofungin, micafungin, and amphotericin B against Candida guilliermondii.
Amphotericin B (AMB), micafungin, and caspofungin MICs, minimal fungicidal concentrations, and time-killing curves were determined in the presence and absence of 10% inactivated serum. AMB was the only agent with consistent killing activity (time required to achieve 99.9% of growth reduction was 2.1 to 3.2 h). The presence of serum enhanced caspofungin activity but lowered those of micafungin and AMB.
Cantón
Emilia
E
Unidad de Microbiología Experimental-Centro de Investigación, Hospital Universitario La Fe, 46009 Valencia, Spain. canton_emi@gva.es
Pemán
Javier
J
Sastre
Macrina
M
Romero
Mónica
M
Espinel-Ingroff
Ana
A
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000382:microbiology; D000077336:Caspofungin; D054714:Echinocandins; D007700:Kinetics; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology*
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D000666:Amphotericin B; D000077336:Caspofungin; D000077551:Micafungin