title: [Influence of acoustic signal with ultrasonic components on the development of defensive conditioned reflex in Wistar rats].
abstract: Short-term (90 s) effects of the complex acoustic signal (CAS) with ultrasonic components on the development of defensive conditioned reflex of two-way active avoidance in a shuttle-box were studied in female Wistar rats. The learning ability of rats was measured on a scale designed in our laboratory. It was shown that CAS stimulation triggered an audiogenic seizure of different strength in 59% of animals. The CAS was extremely stressful for Wistar rats: it prevented the active avoidance learning in early terms after its application (the first training session in 4 or 6 days). This effect did not depend on the presence or intensity of audiogenic seizures during CAS. In the second training session in 9 days (the first session was in 4 days), learning was impaired as compared to control without CAS. However, during repeated training procedure 1.5 months after the CAS (the first session in 6 days), rats rapidly reached the criterion of learning (10 consecutive avoidance reactions). On the other hand, if the CAS was presented with different time lags (immediately, in 3 or in 45 days) after the first training session, the ability of animals to learn during the second session was not impaired both in early and late terms after exposure to the stressor. The results suggest that exposure to CAS prevents development of short-term memory but does not affect consolidation process and long-term memory.
authors.forename: E V
authors.initials: EV
authors.lastname: Loseva
authors.forename: T G
authors.initials: TG
authors.lastname: Alekseeva
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003214:Conditioning, Classical; D005260:Female; D008568:Memory / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000209:etiology / Q000523:psychology; D013315:Stress, Psychological / Q000209:etiology / Q000523:psychology; D014465:Ultrasonics