title: [Pigment deposit in liver of BALB/c mice infected by Schistosoma japonicum and its relation to the effect of praziquantel treatment].
abstract: Pigment is a kind of metabolite excreted by schistosome after erythrocyte ingestion. It deposited first in liver sinusoid, then outside and inside of granuloma, and around eggs. The level of pigment was in parallel with the degree of liver fibrosis (P < 0.01). After chemotherapy with praziquantel, the level of pigment decreased considerably (P < 0.01) and the size of granuloma shrinks obviously too (P < 0.01). Therefore, the degree of liver fibrosis in mice with schistosome infection and the effect of praziquantel can be recognized by the level and distribution of pigment.
authors.affiliation: Examination laboratory, Hangzhou Army Sanitarium, Hangzhou 310007, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tao
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Cai
authors.forename: Bin-bin
authors.initials: BB
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Quan
authors.initials: Q
authors.lastname: Xiang
authors.forename: Rong-hua
authors.initials: RH
authors.lastname: Liu
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use; D003580:Cytochromes / Q000378:metabolism; D005260:Female; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000469:parasitology; D006790:Host-Parasite Interactions; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010270:Parasite Egg Count; D010860:Pigments, Biological / Q000378:metabolism*; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D012549:Schistosoma japonicum / Q000187:drug effects* / Q000502:physiology; D012554:Schistosomiasis japonica / Q000188:drug therapy* / Q000378:metabolism / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D003580:Cytochromes; D010860:Pigments, Biological; D011223:Praziquantel