In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs.
In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.
Davis
Timothy M E
TM
University of Western Australia, School of Medicine and Pharmacology, Crawley, Western Australia 6959, Australia. tdavis@cyllene.uwa.edu.au
Hamzah
Juliana
J
Ilett
Kenneth F
KF
Karunajeewa
Harin A
HA
Reeder
John C
JC
Batty
Kevin T
KT
Hackett
Sara
S
Barrett
P Hugh R
PH
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D066298:In Vitro Techniques; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D011804:Quinolines / Q000494:pharmacology*; D010879:Piperazines
D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D011804:Quinolines; C034759:piperaquine; D010879:Piperazines