Antiviral defense: interferons and beyond.
Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon production and raise important questions regarding the nature of cell-autonomous virus detection in coordinating the antiviral response.
Stetson
Daniel B
DB
Howard Hughes Medical Institute, Yale University School of Medicine, CT 06520, USA. daniel.stetson@yale.edu
Medzhitov
Ruslan
R
D048868:Adaptor Proteins, Signal Transducing / Q000172:deficiency; D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D007370:Interferon Type I / Q000378:metabolism*; D051379:Mice; D009696:Nucleic Acids / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D000998:Antiviral Agents; D007370:Interferon Type I; D009696:Nucleic Acids