[Apoptosis in the regulation of immune response in mice infected with Heligmosomoides polygyrus].
An unbalanced Th1 and Th2 cell subsets response was proposed as the main downregulating mechanisms operating in mice infected with H. polygyrus. During worm infections nonspecific inflammatory and specific immune reactions which might be regulated by apoptosis, coordinate the host protective response. The intensity of apoptosis and proliferation of lymphocytes, the concentration of Th1 and Th2 related cytokines were measured in BALB/c and C57BL6 mice on day 3, 6, 12, 24, 30 after infection with H. polygyrus. Mesenteric lymph nodes (MLN) and popliteal lymph nodes (PLN) lymphocytes underwent an apoptosis, with a different kinetics to the proliferation. Interleukine 5 and IL-6 concentrations increased on time when apoptosis was reduced. No changes in the level of IL-12 were related to intensity of proliferation or apoptosis in both examined strains of mice.
Donskow
Katarzyna
K
Zakład Parazytologii, Instytut Zoologii, Wydział Biologii, Uniwersytet Warszawski, Warszawa.
Rzepecka
Justyna
J
Doligalska
Maria
M
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D006790:Host-Parasite Interactions / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology*; D007378:Interleukins / Q000276:immunology; D007411:Intestinal Diseases, Parasitic / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009351:Nematospiroides dubius / Q000502:physiology; D013045:Species Specificity; D017206:Strongylida Infections / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D007378:Interleukins