Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia.
Total adiponectin concentrations have been shown to increase in serum of preeclamptic women. However, variance of concentrations of different isoforms has not been studied, despite the emerging notion that high, medium and low molecular weight adiponectin exert different functions. We have determined serum concentrations of each adiponectin isoform using a newly developed enzyme immunosorbent assay. High molecular weight (HMW) adiponectin concentrations were significantly higher in women with preeclampsia (n=14; median, 11.2 microg/ml; interquartile range, 9.2-15.8) compared to normal pregnant women (n=14; 6.8 microg/ml, 5.4-10.7; P=0.04). In contrast, medium molecular weight and low molecular weight adiponectin concentrations were substantially equal between the groups. The ratio of HMW adiponectin to total adiponectin was also markedly higher in preeclamptic women (52.3%, 49.5-58.7) than control women (43.0%; 39.8-48.0; P=0.004). Taken together with other reports our findings imply a physiological feedback response to minimize endothelial damage in preeclamptic women.
Takemura
Yuri
Y
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Osuga
Yutaka
Y
Koga
Kaori
K
Tajima
Toshiki
T
Hirota
Yasushi
Y
Hirata
Tetsuya
T
Morimoto
Chieko
C
Harada
Miyuki
M
Yano
Tetsu
T
Taketani
Yuji
Y
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005260:Female; D006801:Humans; D008970:Molecular Weight; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D020033:Protein Isoforms / Q000097:blood
D052242:Adiponectin; D020033:Protein Isoforms