title: Characterization of digoxin and related cardiac glycosides by fast atom bombardment mass spectrometry.
abstract: The potential of using fast atom bombardment mass spectrometry for the detection and the characterization of digoxin and a series of related cardenolide analogues was investigated. The spectra were dependent upon the type of support-matrix in which they were recorded; thioglycerol proved to be satisfactory for the characterization of digoxin and allowed for its detection in human urine extract spiked with ca 11 ng ml(-1).
authors.affiliation: Chemistry and Biology Research Institute, Agriculture Canada, K.W. Neatby Bldg., Ottawa, Ontario K1A 0C6, Canada.
authors.forename: J R
authors.initials: JR
authors.lastname: Paré
authors.forename: P
authors.initials: P
authors.lastname: Lafontaine
authors.forename: J
authors.initials: J
authors.lastname: Bélanger
authors.forename: W W
authors.initials: WW
authors.lastname: Sy
authors.forename: N
authors.initials: N
authors.lastname: Jordan
authors.forename: J C
authors.initials: JC
authors.lastname: Loo