The relationship between anthropometry and serum concentrations of alkaline phosphatase isoenzymes, liver-enzymes, albumin, and bilirubin.
Alkaline phosphatase (ALP) is present in human preadipocytes. The aim of this study was to determine the relationship between anthropometry and serum levels of ALP isoenzymes, liver enzymes, albumin, and bilirubin. Anthropometric variables; serum total, bone, liver, and intestinal ALP levels; and alanine aminotransferase (ALT), albumin, total protein, total bilirubin, and g-glutamyltransferase serum levels were measured in 100 volunteers. The levels (given as median [interquartile range]) for total (74.0 U/L [30.0 U/L] vs 62.0 U/L [22.0 U/L]; P <.05) and liver ALP (37.3 U/L [14.6 U/L] vs 26.1 U/L [12.0 U/L]; P < .05) were higher in obese than in lean subjects. The levels of the other ALP isoenzymes and blood analytes were not significantly different between these groups. Albumin and ALT were the only blood proteins studied with serum levels that correlated significantly with waist circumference. This present study demonstrates a relationship between abdominal obesity and serum ALT levels and between body mass index and ALP levels. These findings suggest that serum ALP, particularly liver ALP, is derived from adipose and hepatic tissue.
Ali
Aus T
AT
Department of Chemical Pathology, National Health, Laboratory Service, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Paiker
Janice E
JE
Crowther
Nigel J
NJ
D000328:Adult; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D001663:Bilirubin / Q000097:blood*; D015992:Body Mass Index; D004435:Eating; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D007978:Levamisole / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis*; D012727:Sex Characteristics
D007527:Isoenzymes; D012709:Serum Albumin; D007978:Levamisole; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin