[Some aspects of the antiarrhythmic effect of glialin].
The antiarrhythmic activity of allapinine and glialin (a complex of allapinin and glycyrrhizic acid) was studied on models of arrhythmias induced in rats and guinea pigs by intravenous administration of calcium chloride, aconitine, barium chloride, and strophanthin. The antiarrhythmic activity of glialin is qualitatively analogous to that of allapinine. The advantage of glialin over allapinin is its low toxicity, which is due to the presence of glycyrrhizic acid.
Khisatmutdinova
R Iu
RIu
Baschenko
N Zh
NZh
Zarudiĭ
F S
FS
Gabdrakhmanova
S F
SF
Makara
N S
NS
Sapozhnikova
T A
TA
D000157:Aconitine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D019695:Glycyrrhizic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D006168:Guinea Pigs; D008297:Male; D051381:Rats
D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019695:Glycyrrhizic Acid; C051402:allapinin; D000157:Aconitine