H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation.
The mechanism of apoptotic signaling by JNK is incompletely understood. In the July 7 issue of Molecular Cell, Lu et al. (2006) report that JNK phosphorylation of H2AX at a noncanonical site is required for caspase-induced DNA fragmentation.
Sluss
Hayla K
HK
Department of Cancer Cell Biology and University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Davis
Roger J
RJ
D017209:Apoptosis / Q000502:physiology*; D053938:DNA Fragmentation; D006657:Histones / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*
C468783:H2AX protein, human; D006657:Histones; D048031:JNK Mitogen-Activated Protein Kinases