Peptide immunization as an adjuvant to chemotherapy in mice challenged intratracheally with virulent yeast cells of Paracoccidioides brasiliensis.
Immunization with peptide P10, derived from gp43, and chemotherapy were used together in an attempt to improve treatment of paracoccidioidomycosis and prevent relapses. The combined treatment showed an additive protective effect when administered at 48 h or 30 days after intratracheal challenge. Its use is recommended to improve regular chemotherapy and reduce the duration of treatment.
Marques
A F
AF
Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, Brazil.
da Silva
M B
MB
Juliano
M A P
MA
Travassos
L R
LR
Taborda
C P
CP
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005656:Fungal Proteins / Q000008:administration & dosage / Q000276:immunology*; D005657:Fungal Vaccines / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007114:Immunization; D007442:Intubation, Intratracheal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D010228:Paracoccidioides / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity*; D010229:Paracoccidioidomycosis / Q000188:drug therapy* / Q000628:therapy*; D010455:Peptides / Q000008:administration & dosage / Q000276:immunology*; D014774:Virulence
D000276:Adjuvants, Immunologic; D000935:Antifungal Agents; D005656:Fungal Proteins; D005657:Fungal Vaccines; D010455:Peptides