title: Simultaneous multiwavelength spectrophotometric quantitation of active components in analgesic formulations. Comparative study of three calculation methods.
abstract: This work deals with the UV spectrophotometric quantitation of a mixture of compounds with overlapped spectra. The mixture spectrum is resolved by use of three computational programs based on different algorithms, namely Multicomponent Analysis (commercial software available from Hewlett-Packard), MULTIC (relying on multiple regression analysis) and SIMPLEX. The results obtained for mixtures of acetylsalicylic acid, acetaminophen and caffeine in commercial analgesic formulations, are compared.
authors.affiliation: Department of Chemistry, Analytical Chemistry Laboratory, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Sala
authors.forename: S
authors.initials: S
authors.lastname: Maspotch
authors.forename: H
authors.initials: H
authors.lastname: Iturriaga
authors.forename: M
authors.initials: M
authors.lastname: Blanco
authors.forename: V
authors.initials: V
authors.lastname: Cerda