Anti-heat shock protein 90 is increased in acute mania.
OBJECTIVE
The aim of this work was to examine autoantibodies in patients with bipolar disorder.


METHODS
We enrolled 94 patients with acute bipolar mania, with 37 of them medicated and 57 unmedicated at the time of blood sampling. The samples also consisted of 44 patients in the remission state and another 48 normal controls. We first used human glioblastoma (U373 MG) cell lysate to screen the potential autoantibodies present in sera of bipolar mania patients, and anti-heat shock protein (anti-HSP) 60, 70 and 90 autoantibodies were identified. We then examined the serum levels of these autoantibodies by enzyme-linked immunosorbent assay.


RESULTS
The findings of this study showed that serum anti-HSP90 level was significantly higher in bipolar patients in acute mania than those in remission (p = 0.002).


CONCLUSIONS
The data of this study suggest that increased anti-HSP90 might be a state marker for acute mania in patients with bipolar disorder.
Shen
Winston W
WW
Graduate Institute of Cell and Molecular Biology, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.
Liu
Hsing-Cheng
HC
Yang
Yi-Yuan
YY
Lin
Chia-Yi
CY
Chen
Kun-Po
KP
Yeh
Tien-Shun
TS
Leu
Sy-Jye
SJ
D000208:Acute Disease; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000175:diagnosis / Q000276:immunology*; D018834:Chaperonin 60 / Q000276:immunology; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology; D018841:HSP90 Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D008297:Male; D012016:Reference Values
D001323:Autoantibodies; D015415:Biomarkers; D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins