[Optimizing effect of the combined administration of 8-OH-DPAT and galantamine on depression--anxiety behavior in old rats with dementia of Alzheimer's type].
The effect of chronic (14 days) administration of the serotonin 5-HT(1A) receptors agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and the 5-HT(1A) receptors antagonist NAN-190 (0.1 mg/kg, i.p.) alone or in combination with the acetylcholinesterase inhibitor galantamine (1.0 mg/kg, i.p.) on depression and anxiety was studied in old (24 months) male rats with dementia of Alzheimer's type. The results indicated that chronic combined administration of 8-OH-DPAT with galantamine resulted in pronounced antidepressant and anxiolytic action.
Sapronov
N S
NS
Fedotova
Iu O
IuO
Losev
N A
NA
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000375:Aging; D000544:Alzheimer Disease; D000818:Animals; D001007:Anxiety; D001522:Behavior, Animal / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003863:Depression; D005702:Galantamine / Q000494:pharmacology; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D058829:Serotonin 5-HT1 Receptor Antagonists; D012702:Serotonin Antagonists / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D010879:Piperazines; D058829:Serotonin 5-HT1 Receptor Antagonists; D012702:Serotonin Antagonists; D005702:Galantamine; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin