title: Nonresponse to 18-month lamivudine monotherapy in chronic hepatitis B patients with dual genotype B and C infection and acute exacerbation.
abstract: Molecular epidemiologic studies have indicated the possible existence of mixed infection of different hepatitis B virus (HBV) genotypes in chronic hepatitis B (CH-B) carriers, but the effect of dual HBV genotype B and C infection on the efficacy of lamivudine therapy remains unclear. We report four CH-B patients with dual HBV genotype B and C infection and acute exacerbation who received lamivudine monotherapy for about 18 months. None of them had achieved a sustained response at the end of the 18-month trial of treatment.
authors.affiliation: Department of Internal Medicine, Division of Hepatogastroenterology, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Sheu
authors.forename: Ching-Yih
authors.initials: CY
authors.lastname: Lin
authors.forename: Chi-Shu
authors.initials: CS
authors.lastname: Sun
authors.forename: Hsing-Tao
authors.initials: HT
authors.lastname: Kuo
authors.forename: Lok-Beng
authors.initials: LB
authors.lastname: Koay
authors.forename: Chuan
authors.initials: C
authors.lastname: Lee
authors.forename: Jyh-Jou
authors.initials: JJ
authors.lastname: Chen
authors.forename: Ling-Yu
authors.initials: LY
authors.lastname: Tang
authors.forename: Sun-Lung
authors.initials: SL
authors.lastname: Tsai
mesh_terms: D000208:Acute Disease; D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral / Q000097:blood; D005838:Genotype; D006515:Hepatitis B virus / Q000145:classification*; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D019259:Lamivudine