title: Labelling monoclonal antibodies with macrocyclic radiometal complexes. A challenge for coordination chemists.
abstract: The technique consisting of labelling antibodies with radionuclides is a promising approach for the diagnosis and therapy of human cancers. In this paper the chemical aspects of radiolabelling with macrocyclic metal complexes are dealt with. The choice of the radioisotope, its coordination chemistry, the design of the bifunctional macrocyclic ligand, and its attachment to the monoclonal antibody are discussed. Finally several newer ideas for a better application are presented.
authors.affiliation: Department of Chemistry, Spitalstrasse 51, 4056 Basel, Switzerland. th.kaden@.unibas.ch
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Kaden
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D007553:Isotope Labeling / Q000379:methods; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D011868:Radioisotopes
chemical_list: D000911:Antibodies, Monoclonal; D002614:Chelating Agents; D047028:Macrocyclic Compounds; D008670:Metals; D011868:Radioisotopes; D003300:Copper