title: External and internal exposure to polycyclic aromatic hydrocarbons (PAH) among workers in the production of fire-proof materials - proposal of a biological monitoring guidance value.
abstract: In 1999, we introduced the German polycyclic aromatic hydrocarbons (PAH) study. The study was designed as a nation-wide investigation on workers exposed to PAH. One aim of the study was to establish biological monitoring guidance values (BMGVs) for different branches. Here, we report on the production of fire-proof materials. This branch of industry is typically confronted with high exposure to PAH and with PAH-induced occupational (cancer) diseases. One hundred and thirty-five employees participated in the course of seven sampling dates in four different plants in Germany. External exposure was determined by personal air monitoring of the 16 EPA-PAH. Human biological monitoring was accomplished by the determination of 1-hydroxypyrene and monohydroxyphenanthrenes in post-shift spot urine samples. Concentrations of PAH in the air of the workplaces ranged up to 1102.6microg/m(3). Maximum benzo[a]pyrene concentration was 38.2microg/m(3). The internal PAH exposure of workers was much higher compared with that of the general population. Median concentration for 1-hydroxypyrene was 6.4microg/g creatinine (maximum 279.6, 90th percentile 23.9microg/g creatinine) and for the sum of monohydroxyphenanthrene metabolites 13.3microg/g creatinine (maximum 313.4, 90th percentile 70.8microg/g creatinine). The following BMGVs for the non-smokers of this branch of industry are proposed: for 1-hydroxypyrene 18microg/g creatinine and for the sum of hydroxyphenanthrenes 77microg/g creatinine in urine measured at the end of the shift.
authors.affiliation: University of Erlangen-Nuremberg, Institute and Outpatient Clinic of Occupational, Social- and Environmental Medicine, Erlangen, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Preuss
authors.forename: Bernd
authors.initials: B
authors.lastname: Rossbach
authors.forename: Michael
authors.initials: M
authors.lastname: Wilhelm
authors.forename: Thomas
authors.initials: T
authors.lastname: Brüning
authors.forename: Jürgen
authors.initials: J
authors.lastname: Angerer
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods / Q000592:standards*; D005858:Germany; D006801:Humans; D007221:Industry; D008875:Middle Aged; D016273:Occupational Exposure; D010616:Phenanthrenes / Q000652:urine; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D011721:Pyrenes / Q000032:analysis; D012907:Smoking; D020711:Threshold Limit Values
chemical_list: D000395:Air Pollutants, Occupational; D010616:Phenanthrenes; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes