[Not Available].
Changes in the ultraviolet absorption spectra with pH in aqueous solution were used to determine the pKA values of amidines. A new mathematical procedure was used to study sparingly soluble compounds. In this technique, all the experimental data are used to solve for the absorbance of the insoluble basic species and for the pKA value by a 'complex method' of optimization, which is more general than the classical least-squares method. A relationship between a double bond vibration frequency and the acidity constants of these compounds has been demonstrated.
Hanocq
M
M
Institut de Pharmacie, Université Libre de Bruxelles, Campus Plaine CP 205/1, Boulevard du Triomphe, 1050 Bruxelles, Belgique.
Van Damme
M
M
Fuks
R
R