[ Effect of Mebendazole on the activity of superoxide dismutase and catalase in the liver of rats infected with Trichinella spiralis].
By administering mebendazolum to control the trichinella invaded white linear rats it was showed that mebendazolum does not have direct effect on activity of liver antioxidizing enzyme, however it increases prooxidantal effect of trichinella metabolite, which in condition of invaded organism appears to be a supplementary pathogenic factor.
Tolstoy
Viktor
V
Katedra Biologii Medycznej, Białoruski Państwowy Uniwersytet Medyczny, Mińsk, Białoruś.
Salamatin
Rusłan
R
Grytner-Ziecina
Barbara
B
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology; D002374:Catalase / Q000187:drug effects* / Q000378:metabolism; D006790:Host-Parasite Interactions; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000469:parasitology; D008463:Mebendazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects* / Q000378:metabolism; D017160:Trichinella spiralis; D014235:Trichinellosis / Q000188:drug therapy* / Q000201:enzymology
D000969:Antinematodal Agents; D008463:Mebendazole; D002374:Catalase; D013482:Superoxide Dismutase