Fully-automated assay by liquid chromatography for routine drug monitoring in body fluids--method development with biological samples.
A fully-automated liquid chromatograph based on alternated pre-column enrichment technique has been developed for routine drug monitoring of body fluids using a column switching technique. Advantages of the method include the facility of direct injection of the body fluid onto the chromatograph and the simultaneous detection of both polar and non-polar metabolites under isocratic or gradient elution conditions.
Roth
W
W
Department of Biochemistry, Dr. K. Thomae GmbH, Postfach 17 55, 7950 Biberach, FRG.
Beschke
K
K