title: Isolation of meclofenamic acid and two metabolites from equine urine--a comparison between horse and man.
abstract: Two metabolites of meclofenamic acid have been isolated from equine urine. Both metabolites are found to be monohydroxylated forms of meclofenamic acid by gas chromatography-mass spectrometry after extractive alkylation. The parent drug and the metabolites are separated by reversed-phase liquid chromatography on a Spherisorb ODS column, using methanol-phosphate buffer eluents and UV detection at 280 nm. The structure of the metabolites is discussed on the basis of LC, TLC and GC-MS data.
authors.affiliation: Swedish University of Agricultural Sciences, Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Biomedical Center, Box 573, S-751 23 Uppsala, Sweden.
authors.forename: I M
authors.initials: IM
authors.lastname: Johansson
authors.forename: E L
authors.initials: EL
authors.lastname: Anlér
authors.forename: U
authors.initials: U
authors.lastname: Bondesson
authors.forename: B
authors.initials: B
authors.lastname: Schubert