Autophagy vs. Group A Streptococcus.
We have identified several mammalian protein components of the autophagy pathway. By using them as powerful tools to examine the functional significance of this degradation pathway, we recently showed that autophagy efficiently kills a pathogenic bacterium, Group A Streptococcus, after it invades host cells. However, the autophagosomes induced by these bacteria have features distinct from those of the canonical pathway.
Yoshimori
Tamotsu
T
Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. tamyoshi@lab.nig.ac.jp
D001343:Autophagy / Q000502:physiology*; D000071187:Autophagy-Related Protein 5; D006801:Humans; D007113:Immunity, Innate; D008869:Microtubule-Associated Proteins / Q000502:physiology; D011135:Polysaccharides, Bacterial / Q000502:physiology; D013289:Streptococcaceae / Q000472:pathogenicity / Q000502:physiology*
C502778:ATG5 protein, human; D000071187:Autophagy-Related Protein 5; C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins; D011135:Polysaccharides, Bacterial; C036112:streptococcal polysaccharide group A