title: Frontal lobe metabolic decreases with sleep deprivation not totally reversed by recovery sleep.
abstract: We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.
authors.affiliation: UC Irvine Department of Psychiatry and Human Behavior, Irvine, CA, USA. jcwu@uci.edu
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Wu
authors.forename: J Christian
authors.initials: JC
authors.lastname: Gillin
authors.forename: Monte S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: Phillip
authors.initials: P
authors.lastname: Chen
authors.forename: David B
authors.initials: DB
authors.lastname: Keator
authors.forename: Neetika
authors.initials: N
authors.lastname: Khosla Wu
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Darnall
authors.forename: James H
authors.initials: JH
authors.lastname: Fallon
authors.forename: William E
authors.initials: WE
authors.lastname: Bunney
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D020127:Recovery of Function / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D013788:Thalamus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology