title: Analysis of some dosage forms containing pyridine derivatives using a cyclodextrin bonded stationary phase in HPLC.
abstract: The high performance liquid chromatography of some pyridine derivatives using a silica column to which beta-cyclodextrin has been bonded, has been investigated. In spite of the low affinity constants of the drugs for cyclodextrin (of the order of 10(2) M(-1)) good separations can be achieved using a mobile phase of methanol and pH 7.0 phosphate. Good analysis of some dosage forms are achieved, including one on a tablet containing pheniramine maleate, pyrilamine maleate and phenylpropanolamine hydrochloride. Extractions and chromatography are quick and simple.
authors.affiliation: Department of Pharmacy, University of Assiut, Assiut Egypt.
authors.forename: S
authors.initials: S
authors.lastname: El Gezawi
authors.forename: N
authors.initials: N
authors.lastname: Omar
authors.forename: N
authors.initials: N
authors.lastname: El Rabbat
authors.forename: J H
authors.initials: JH
authors.lastname: Perrin