title: Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides.
abstract: A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 microM) and demonstrated modest adhesion inhibition to cell surface CSA.
authors.affiliation: Hygiene-Institut, Abteilung Parasigologie, Universität Heidelberg, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Adams
authors.forename: Craig
authors.initials: C
authors.lastname: Freeman
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schwartz-Albiez
authors.forename: Vito
authors.initials: V
authors.lastname: Ferro
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Parish
authors.forename: Katherine T
authors.initials: KT
authors.lastname: Andrews
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002809:Chondroitin Sulfates / Q000494:pharmacology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006497:Heparan Sulfate / Q000494:pharmacology*; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D009844:Oligosaccharides / Q000378:metabolism / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000166:cytology / Q000187:drug effects*; D013431:Sulfates / Q000737:chemistry
chemical_list: D000962:Antimalarials; D002809:Chondroitin Sulfates; D006497:Heparan Sulfate; D009844:Oligosaccharides; D013431:Sulfates