Telomere shortening with aging in the human pancreas.
We have conducted systematic studies to measure telomere length in human tissues of all types. Progressive telomere shortening with aging was studied in specimens of normal pancreas obtained at autopsy from 69 subjects aged 0 to 100 yr, and age-related shortening of telomere length at a rate of 36 base pairs (bp) per year was detected. Mean telomere length (+/-SD) was 13.9+/-1.4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/-SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5+/-1.5, 12.3+/-0.7, 11.3+/-2.5, and 10.7+/-1.8, respectively.
Ishii
Akio
A
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. aishii@tmig.or.jp
Nakamura
Ken-Ichi
K
Kishimoto
Hiroshi
H
Honma
Naoko
N
Aida
Junko
J
Sawabe
Motoji
M
Arai
Tomio
T
Fujiwara
Mutsunori
M
Takeuchi
Fujio
F
Kato
Motonobu
M
Oshimura
Mitsuo
M
Izumiyama
Naotaka
N
Takubo
Kaiyo
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D008136:Longevity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D016615:Telomere / Q000235:genetics*
D004247:DNA