title: Postpartum acquired factor VIII inhibitors.
abstract: The development of factor VIII autoantibodies is a rare but severe complication of pregnancy. Although the natural history of postpartum acquired hemophilia A is usually benign, with a high percentage of spontaneous remissions and a low mortality, its quick recognition is important to control bleeding episodes. Based on an analysis of the literature, this review presents the current knowledge on the pathogenesis, diagnosis, epidemiology, natural history, clinical manifestations, and therapeutic management of postpartum acquired hemophilia A.
authors.affiliation: Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy. mfranchini@univr.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
mesh_terms: D001323:Autoantibodies / Q000097:blood; D003029:Coagulants / Q000627:therapeutic use; D005169:Factor VIII / Q000276:immunology* / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D011247:Pregnancy
chemical_list: D001323:Autoantibodies; D003029:Coagulants; D005169:Factor VIII