Noninvasive detection of fetal sex: the laboratory diagnostician's view.
Toward the end of the twentieth century it was discovered that cell-free fetal DNA sequences could be detected in maternal blood plasma. Initially, Y-chromosome sequences originating from male fetuses were targeted in cell-free DNA extracted from maternal plasma in order to demonstrate proof of this concept towards the development of noninvasive prenatal diagnosis methods. Clinical application of this approach is now possible. Fetal sex can be detected through a procedure that is noninvasive with respect to the fetus. Specifically, the presence of Y-chromosome sequences in maternal blood plasma indicates that the fetus is male, whereas lack of a signal will indicate that the fetus is female. Fetal sex can be detected very early, from at least the 7th week of pregnancy (and even earlier, according to several studies), about two months before this information is available through ultrasound scanning. Although the controversial issue of fetal sexing is not new, it is expected that with the availability of an accurate noninvasive test, public interest will rise. It is therefore imperative that an authorized committee of experts in each country generates an official policy regarding application of the test.
Guetta
Esther
E
Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel. Esther.Guetta@sheba.health.gov.il
D001290:Attitude; D004247:DNA / Q000097:blood*; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000175:diagnosis; D006801:Humans; D007557:Israel; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012732:Sex Determination Analysis / Q000941:ethics / Q000379:methods*; D012743:Sex Preselection
D004247:DNA