Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models.
Extracts of Ginkgo biloba (EGB) are a complex product prepared from green leaves of the Ginkgo biloba tree. In the present study, the antidepressant effect of EGB was examined using two behavioral models, the forced swimming test (FST) in rats and tail suspension test (TST) in mice. EGB significantly reduced immobility time in the FST at a dosage of 10 and 50 mg/kg body weight after repeated oral treatment for 14 d, although no change of motor dysfunction was observed with the same dosage in the open field test. These results indicate that EGB might possess an antidepressant activity. In addition, EGB markedly shortened immobility time in the TST after acute inter-peritoneal treatment at a dosage of 50 and 100 mg/kg body weight. The present study clearly demonstrated that EGB exerts an antidepressant effect in these two behavioral models.
Sakakibara
Hiroyuki
H
Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
Ishida
Kaori
K
Grundmann
Oliver
O
Nakajima
Jun-ichiro
J
Seo
Shujiro
S
Butterweck
Veronika
V
Minami
Yuko
Y
Saito
Satomi
S
Kawai
Yoshichika
Y
Nakaya
Yutaka
Y
Terao
Junji
J
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D020441:Ginkgo biloba / Q000737:chemistry*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats
D000928:Antidepressive Agents; D010936:Plant Extracts