Quetiapine and citalopram: aetiological significances in serotonin syndrome.
The use of atypical antipsychotic medication is increasing, with an increase in reported side-effects. The first reported case of quetiapine and citalopram-associated serotonin syndrome is discussed with reference to a Medline, Embase, and PsycINFO literature search. The putative aetiological mechanism is supersensitivity of 5-HT(1A) receptors (quetiapine) within an environment of increased synaptic available serotonin (citalopram). The symptom profile of serotonin syndrome overlaps with neuroleptic malignant syndrome, but can be reliably differentiated using a time and toxicity scale.
Marlowe
Karl
K
Tower Hamlets Early Intervention Service, Royal London Hospital, St Clement's, 2A Bow Road, Mile End, London E3 4LL, UK. karl.marlowe@elcmht.nhs.uk
Schirgel
Dorothea
D
D000328:Adult; D000525:Alprazolam / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D015283:Citalopram / Q000009:adverse effects*; D003987:Dibenzothiazepines / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000069348:Quetiapine Fumarate; D018967:Risperidone / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000188:drug therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D016896:Treatment Outcome
D000525:Alprazolam; D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D015283:Citalopram; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D018967:Risperidone; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors