title: Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques.
abstract: The non-invasive nature of arterial spin labelling (ASL) has opened a unique window into human brain function and perfusion physiology. High spatial and temporal resolution makes the technique very appealing not only for the diagnosis of vascular diseases, but also in basic neuroscience where the aim is to develop a more comprehensive picture of the physiological events accompanying neuronal activation. However, low signal-to-noise ratio and the complexity of flow quantification make ASL one of the more demanding disciplines within MRI. In this review, the theoretical background and main implementations of ASL are revisited. In particular, the perfusion quantification methods, including the problems and pitfalls involved, are thoroughly discussed in this article. Finally, a brief summary of applications is provided.
authors.affiliation: Department of Neuroradiology, National Neuroscience Institute, Singapore.
authors.forename: E T
authors.initials: ET
authors.lastname: Petersen
authors.forename: I
authors.initials: I
authors.lastname: Zimine
authors.forename: Y-C L
authors.initials: YC
authors.lastname: Ho
authors.forename: X
authors.initials: X
authors.lastname: Golay
mesh_terms: D002536:Cerebral Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008954:Models, Biological; D013113:Spin Labels
chemical_list: D013113:Spin Labels