Multifocal choroiditis in disseminated Cryptococcus neoformans infection.
OBJECTIVE
To report an uncommon case of multifocal choroiditis as the result of disseminated Cryptococcus neoformans infection in a patient who is HIV-positive.


METHODS
Interventional case report.


METHODS
A 27-year-old HIV-positive woman with fever, headache, and vomiting was examined. Lumbar puncture was performed and revealed C neoformans infection. Her condition evolved with sudden bilateral blindness and deafness. Ophthalmologic examination revealed multiple yellowish choroidal lesions in the posterior pole of both eyes.


RESULTS
Postmortem examination showed disseminated C neoformans infection. Histologic examination of the eyes confirmed the presence of C neoformans in the choroiditis.


CONCLUSIONS
Multifocal choroiditis in C neoformans infection is a rare ophthalmic manifestation. The recognition of this condition by ophthalmologists can help physicians to diagnose a disseminated and fatal disease.
Andreola
Carla
C
Department of Ophthalmology, AIDS Section, Centro Previdenciário de Niterói, Rio de Janeiro, Brazil.
Ribeiro
Maria P D
MP
de Carli
Carla R S
CR
Gouvea
Ana Luisa F
AL
Curi
André L L
AL
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D001766:Blindness / Q000209:etiology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002833:Choroiditis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D003453:Cryptococcosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D003638:Deafness / Q000209:etiology; D004359:Drug Therapy, Combination; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D013129:Spinal Puncture
D000935:Antifungal Agents; D000998:Antiviral Agents