(De)constructing mitochondria: what for?
Mitochondria are dynamic organelles, essential for cell life and death. The morphology of this organelle is determined by fusion and fission, controlled by a growing set of "mitochondria-shaping" proteins, which influence crucial signalling cascades, including apoptosis.
Dimmer
Kai S
KS
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, I-35129 Padova, Italy.
Scorrano
Luca
L
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D049109:Cell Proliferation; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D004272:DNA, Mitochondrial / Q000235:genetics; D034281:Dynamins; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000502:physiology; D008928:Mitochondria / Q000502:physiology* / Q000648:ultrastructure*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000502:physiology / Q000648:ultrastructure; D015398:Signal Transduction / Q000502:physiology
D004272:DNA, Mitochondrial; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D000255:Adenosine Triphosphate; D020558:GTP Phosphohydrolases; C415198:OPA1 protein, human; C110768:DNM1L protein, human; D034281:Dynamins