Staphyloxanthin plays a role in the fitness of Staphylococcus aureus and its ability to cope with oxidative stress.
Staphyloxanthin is a membrane-bound carotenoid of Staphylococcus aureus. Here we studied the interaction of staphyloxanthin with reactive oxygen substances (ROS) and showed by comparative analysis of the wild type (WT) and an isogenic crtM mutant that the WT is more resistant to hydrogen peroxide, superoxide radical, hydroxyl radical, hypochloride, and neutrophil killing.
Clauditz
Alexandra
A
Mikrobielle Genetik, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
Resch
Alexandra
A
Wieland
Karsten-Peter
KP
Peschel
Andreas
A
Götz
Friedrich
F
D015169:Colony Count, Microbial; D003470:Culture Media; D018869:Heat-Shock Response; D009154:Mutation; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress / Q000502:physiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D024341:Xanthophylls / Q000235:genetics / Q000378:metabolism*
D003470:Culture Media; D016877:Oxidants; D024341:Xanthophylls; C031841:staphyloxanthin