title: Hyperpolarized 3helium magnetic resonance ventilation imaging of the lung in cystic fibrosis: comparison with high resolution CT and spirometry.
abstract: The purpose of this study was to compare hyperpolarized 3helium magnetic resonance imaging (3He MRI) of the lungs in adults with cystic fibrosis (CF) with high-resolution computed tomography (HRCT) and spirometry. Eight patients with stable CF prospectively underwent 3He MRI, HRCT, and spirometry within 1 week. Three-dimensional (3D) gradient-echo sequence was used during an 18-s breath-hold following inhalation of hyperpolarized 3He. Each lung was divided into six zones; 3He MRI was scored as percentage ventilation per lung zone. HRCT was scored using a modified Bhalla scoring system. Univariate (Spearman rank) and multivariate correlations were performed between 3He MRI, HRCT, and spirometry. Results are expressed as mean+/-SD (range). Spirometry is expressed as percent predicted. There were four men and four women, mean age = 31.9+/-9 (20-46). Mean forced expiratory volume in 1 s (FEV)1 = 52%+/-29 (27-93). Mean 3He MRI score = 74%+/-25 (55-100). Mean HRCT score = 48.8+/-24 (13.5-83). The correlation between 3He MRI and HRCT was strong (R = +/-0.89, p < 0.001). Bronchiectasis was the only independent predictor of 3He MRI; 3He MRI correlated better with FEV1 and forced vital capacity (FVC) (R = 0.86 and 0.93, p < 0.01, respectively) than HRCT (R = +/-0.72 and +/-0.81, p < 0.05, respectively). This study showed that 3He MRI correlates strongly with structural HRCT abnormalities and is a stronger correlate of spirometry than HRCT in CF.
authors.affiliation: Department of Radiology, St. Vincent's University Hospital, Dublin 4, Ireland. colmjmcmahon@yahoo.co.uk
authors.forename: Colm J
authors.initials: CJ
authors.lastname: McMahon
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Dodd
authors.forename: Catherine
authors.initials: C
authors.lastname: Hill
authors.forename: Neil
authors.initials: N
authors.lastname: Woodhouse
authors.forename: Jim M
authors.initials: JM
authors.lastname: Wild
authors.forename: Stan
authors.initials: S
authors.lastname: Fichele
authors.forename: Charles G
authors.initials: CG
authors.lastname: Gallagher
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Skehan
authors.forename: Edwin J R
authors.initials: EJ
authors.lastname: van Beek
authors.forename: James B
authors.initials: JB
authors.lastname: Masterson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001987:Bronchiectasis / Q000175:diagnosis; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006371:Helium; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007554:Isotopes; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012107:Research Design; D012720:Severity of Illness Index; D013147:Spirometry; D014057:Tomography, X-Ray Computed; D014797:Vital Capacity
chemical_list: D007554:Isotopes; D006371:Helium