Anti-endothelial antibodies and neuropsychiatric systemic lupus erythematosus.
The pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) has been attributed to autoantibody-mediated neural dysfunction, vasculopathy, and coagulopathy. Several autoantibodies specificities have been reported in serum and cerebrospinal fluid of NPSLE patients (i.e., antineuronal, antiribosomal P proteins, antiglial fibrillary acidic proteins, antiphospholipid, and anti-endothelial antibodies). We have recently demonstrated an association between serum anti-endothelial antibodies and psychosis or depression in patients with SLE. Subsequently, by screening a cDNA library from human umbilical artery endothelial cells with serum from a SLE patient with psychosis, one positive strongly reactive clone was identified encoding the C-terminal region (C-ter) of Nedd5, an intracytoplasmatic protein of the septin family. Anti-Nedd5 antibodies have been found significantly associated with psychiatric manifestations in SLE patients, strengthening the view of a possible implication of autoantibodies in the development of psychiatric disorders.
Valesini
Guido
G
Dipartimento di Clinica e Terapia Medica Applicata, Cattedra e Divisione di Reumatologia, Università La Sapienza, V.le del Policlinico 155, 00161 Rome, Italy. guido.valesini@uniroma1.it
Alessandri
Cristiano
C
Celestino
Domenico
D
Conti
Fabrizio
F
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D004727:Endothelium / Q000276:immunology*; D006801:Humans; D020945:Lupus Vasculitis, Central Nervous System / Q000276:immunology*; D010744:Phosphoric Monoester Hydrolases / Q000276:immunology
D000906:Antibodies; D010744:Phosphoric Monoester Hydrolases