Polycystic ovary syndrome in bulimic women--an evaluation based on the new diagnostic criteria.
An association between bulimia nervosa and polycystic ovary syndrome (PCOS) has been suggested but also questioned. Since there is still a controversy about this issue, we investigated clinical and biochemical symptoms of PCOS according to the new diagnostic criteria in a large group of bulimic women compared with controls. Seventy-seven women with bulimia and 59 matched healthy women were investigated with respect to menstrual status, polycystic ovaries, hirsutism, acne and sex hormone levels. We found increased occurrence of menstrual disturbances, hirsutism and PCOS in bulimic women, whereas ovarian variables and acne did not differ from controls. Hirsutism score and indices of biologically active testosterone were positively correlated in bulimics but not in controls, while there were no major differences in serum androgens. In conclusion, this study supports an increased frequency of PCOS in bulimic women and may also indicate increased androgen sensitivity in these women. PCOS may promote bulimic behavior since androgens have appetite-stimulating effects and could impair impulse control. Menstrual disturbances and clinical signs of hyperandrogenism should be evaluated in bulimics in order to provide adequate medical care and treatment.
Naessén
Sabine
S
Department of Women and Child Health, Division of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden. Sabine.Naessén@karolinska.se
Carlström
Kjell
K
Garoff
Leena
L
Glant
Rolf
R
Hirschberg
Angelica Lindén
AL
D000328:Adult; D002032:Bulimia / Q000150:complications* / Q000175:diagnosis*; D016022:Case-Control Studies; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood; D006628:Hirsutism / Q000175:diagnosis; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008599:Menstruation Disturbances / Q000175:diagnosis; D009839:Oligomenorrhea / Q000175:diagnosis; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000175:diagnosis*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin; D003687:Dehydroepiandrosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone