title: DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children.
abstract: In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.
authors.affiliation: Department of Developmental and Reproductive Sciences, University of Trieste, Trieste, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Milanese
authors.forename: Ludovica
authors.initials: L
authors.lastname: Segat
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pontillo
authors.forename: Luiz Claudio
authors.initials: LC
authors.lastname: Arraes
authors.forename: José Luiz
authors.initials: JL
authors.lastname: de Lima Filho
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
mesh_terms: D000293:Adolescent; D000890:Anti-Infective Agents; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D007223:Infant; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D023083:beta-Defensins / Q000235:genetics*
chemical_list: D000890:Anti-Infective Agents; C406407:DEFB1 protein, human; D005819:Genetic Markers; D023083:beta-Defensins