Cysteine proteinase inhibitors in murine cysticercosis.
We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.
Baig
Salman
S
Department of Cellular Biology, University of Georgia, Athens, Georgia 30603, USA.
Damian
Raymond T
RT
Morales-Montor
Jorge
J
Thazhath
Rupal
R
Ghaleb
Amr
A
Welch
Meredith
M
Talhouk
Jamil
J
White
A Clinton
AC
D000818:Animals; D002473:Cell Wall / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D015853:Cysteine Proteinase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D003551:Cysticercosis / Q000517:prevention & control*; D003552:Cysticercus / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D003560:Cysts / Q000188:drug therapy / Q000473:pathology / Q000648:ultrastructure; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D007274:Injections, Intraperitoneal; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D013154:Spleen / Q000166:cytology
D015853:Cysteine Proteinase Inhibitors; D004791:Enzyme Inhibitors