title: Favorable entropy of aromatic clusters in thermophilic proteins.
abstract: Aromatic clusters, found with increased frequency in a set of thermophilic proteins, confer an entropic advantage over mesophilic analogues through introduction of large-amplitude oscillations; this is a source of improved free energy at high temperatures.
authors.affiliation: Dipartimento di Chimica G. Ciamician, Università di Bologna, via F. Selmi 2, 40126 Bologna, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Trebbi
authors.forename: Francois
authors.initials: F
authors.lastname: Dehez
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Fowler
authors.forename: Francesco
authors.initials: F
authors.lastname: Zerbetto
mesh_terms: D000595:Amino Acid Sequence; D024322:Amino Acids, Aromatic / Q000737:chemistry*; D002151:Calorimetry; D019277:Entropy; D004798:Enzymes / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D024322:Amino Acids, Aromatic; D004798:Enzymes; D011506:Proteins