[Differential contribution of dopamine D1 and D2 receptors in the mu-opioidergic immunomodulation].
The study has shown that activation of mu-opioid receptors by a highly selective agonist DAGO (100 microg/kg) results in a significant increase of the immune response to antigen (SRBC, 5% 10(8)) in CBA mice. Haloperidol (2 mg/kg), a selective antagonist of the postsynaptic dopamine (DA) receptors, prevented immunostimulating effect of DAGO. In contrast, selective D1--antagonist SCH 23390 (1 mg/kg) did not affect on DAGO-induced enhancing of immune reactivity. At the same time, the blockade of both types of DA receptors (D1 and D2) caused similar immunosuppressing effects. These data suggest a possible differential role for D1 and D2 receptors in mu-opioidergic immunomodulation.
Cheĭdo
M A
MA
Idova
G V
GV
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000276:immunology; D017448:Receptors, Dopamine D2 / Q000276:immunology; D017450:Receptors, Opioid, mu / Q000819:agonists* / Q000276:immunology
D000701:Analgesics, Opioid; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D006220:Haloperidol