title: Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case.
abstract: This report describes the 12th documented case of histiocytoid, diffuse or signet-ring cell eccrine sweat gland carcinoma of the eyelid, a rare neoplasm that characteristically affects older men and mimics distant metastasis. Clinically, the patient was thought to have a colonic metastasis. Histologically, the neoplasm comprised sheets and cords of polygonal, eosinophilic cells, with dispersed larger, rounded single cells resembling histiocytes, and cells with cytoplasmic lumina or a signet-ring appearance. Occasional duct formation was also seen. The features were reminiscent of both the histiocytoid and lobular variants of breast carcinoma. Ultrastructurally, the presence of nonintestinal type microvilli with a length : width ratio in excess of 16 were consistent with an eccrine origin, but also raised the possibility of metastatic mesothelioma. However, a metastatic lesion was excluded by clinical and imaging investigations. There has been no recurrence 3 years after primary excision.
authors.affiliation: Oral and Maxillofacial Pathology Unit, Eastman Dental Institute for Oral Healthcare Sciences, University College London, University of London, London, UK.
authors.forename: B
authors.initials: B
authors.lastname: Swinson
authors.forename: F
authors.initials: F
authors.lastname: Ryan
authors.forename: A W
authors.initials: AW
authors.lastname: Barrett
authors.forename: W
authors.initials: W
authors.lastname: Jerjes
authors.forename: G
authors.initials: G
authors.lastname: Landon
authors.forename: E
authors.initials: E
authors.lastname: Calonje
authors.forename: N
authors.initials: N
authors.lastname: Kalavrezos
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000556:secondary; D000368:Aged; D003110:Colonic Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D004439:Eccrine Glands; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D013544:Sweat Gland Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure