Synthesis of potential biologically active 1,2-benzothiazin-3-yl-quinazolin-4(3H)-ones.
A series of potential biologically active 2-(4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)quinazolin-4(3H)-ones was synthesized in a straight forward manner by condensation of respective 4-hydroxy-1,2-benzothiazine-1,1-dioxides with anthranilamide followed by simple and high throughput cyclization of N-[2-(aminocarbonyl)phenyl]-4-hydroxy-1,2-benzothiazine-3-carboxamide-1,1-dioxides. All the synthesized compounds were subjected to preliminary evaluation for their biological activity against Gram positive and Gram negative bacteria. Some of the assayed compounds showed marked activity against Bacillus subtilis.
Zia-ur-Rehman
Muhammad
M
Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore-54600, Pakistan. rehman_pcsir@hotmail.com
Choudary
Jamil Anwar
JA
Ahmad
Saeed
S
Siddiqui
Hamid Latif
HL
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D062367:ortho-Aminobenzoates / Q000737:chemistry
D000900:Anti-Bacterial Agents; D011799:Quinazolines; D013843:Thiazines; D062367:ortho-Aminobenzoates; C000219:anthranilamide