title: Interferon alpha sensitisation induced fatal renal insufficiency in a patient with chronic myeloid leukaemia: case report and review of literature.
abstract: Renal dysfunction as a sequel to extended interferon alfa (IFNalpha) treatment in chronic myeloid leukaemia (CML) has been reported previously in six patients. An additional patient is presented with Philadelphia chromosome positive (Ph+) CML and nephrotic syndrome in whom initial renal insufficiency developed after only one month of low dose IFNalpha therapy. The renal biopsy showed a focal segmental mononuclear cell infiltration, basal membrane thickening, and deposits of immunoglobulins (IgG; IgAGM IC3). In spite of discontinuation of IFNalpha, renal function deteriorated and the patient died six months later. This case represents an instance of fatal kidney insufficiency as an untoward effect of sensitisation to the IFNalpha, confirmed by modified Coombs assay.
authors.affiliation: Institute of Haematology, School of Medicine, University of Belgrade, Serbia.
authors.forename: M
authors.initials: M
authors.lastname: Colovic
authors.forename: V
authors.initials: V
authors.lastname: Jurisic
authors.forename: G
authors.initials: G
authors.lastname: Jankovic
authors.forename: D
authors.initials: D
authors.lastname: Jovanovic
authors.forename: L J
authors.initials: LJ
authors.lastname: Nikolic
authors.forename: J
authors.initials: J
authors.lastname: Dimitrijevic
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha