title: Case report: Aggressive blood pressure management for carotid endarterectomy hyperperfusion syndrome.
abstract: OBJECTIVE
  Cerebral hyperperfusion syndrome (CHS) is a rare but potentially devastating complication following cerebral revascularization. Management of CHS requires aggressive blood pressure control to prevent stroke and intracerebral hemorrhage. This case report documents a severe case of CHS, and outlines a successful outcome associated with aggressive blood pressure control.
  
  
  METHODS
  A 67-yr-old gentleman, nine days post left carotid endarterectomy, required tracheal intubation and intensive care unit admission following seizures and acute right-sided weakness. A computed tomography scan and magnetic resonance imaging revealed significant vasogenic edema in the left middle cerebral artery territory, without evidence of infarction. The history and radiographic findings suggested CHS. As such, a systolic blood pressure target was set at 90-140 mmHg. This blood pressure parameter was lower than typically targeted following acute ischemic or hemorrhagic stroke. Rapid clinical improvements were seen by day five, and tight blood pressure control was maintained throughout. Repeat computed tomography and magnetic resonance imaging revealed improved edema and no evidence of infarct or hemorrhage.
  
  
  CONCLUSIONS
  Cerebral hyperperfusion syndrome is believed to occur following restoration of blood flow to a brain with impaired autoregulation due to chronic hypoperfusion. Massive brain edema and hemorrhage can result from higher pressures. Clinicians should be aware of this potential complication following cerebral revascularization procedures, and the importance of establishing blood pressure targets which are considerably lower than for other patients with similar clinical presentations.
authors.affiliation: Division of Neurology, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: James
authors.initials: J
authors.lastname: Scozzafava
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Hussain
authors.forename: Tom
authors.initials: T
authors.lastname: Yeo
authors.forename: Thomas
authors.initials: T
authors.lastname: Jeerakathil
authors.forename: Peter G
authors.initials: PG
authors.lastname: Brindley
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D001929:Brain Edema / Q000209:etiology / Q000628:therapy; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003422:Critical Care; D038524:Diffusion Magnetic Resonance Imaging; D016894:Endarterectomy, Carotid / Q000009:adverse effects*; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D020768:Middle Cerebral Artery / Q000473:pathology; D015427:Reperfusion Injury / Q000209:etiology / Q000628:therapy*; D012640:Seizures / Q000209:etiology / Q000628:therapy; D020521:Stroke / Q000209:etiology / Q000628:therapy; D013577:Syndrome; D014057:Tomography, X-Ray Computed