Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model.
Herein we describe a small-molecule, non-peptidic, inhibitor for botulinum neurotoxin A protease, that displays for the first time efficacy in a cell-based assay.
Boldt
Grant E
GE
Department of Chemistry and Immunology, Skaggs Institute for Chemical Biology, Worm Institute for Research Medicine (WIRM), Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Eubanks
Lisa M
LM
Janda
Kim D
KD
D000818:Animals; D001681:Biological Assay; D019274:Botulinum Toxins, Type A / Q000037:antagonists & inhibitors*; D051379:Mice; D009447:Neuroblastoma / Q000201:enzymology* / Q000473:pathology; D009498:Neurotoxins / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D009498:Neurotoxins; D011480:Protease Inhibitors; D019274:Botulinum Toxins, Type A