Effect of chelation to lanthanum ions on the photodynamic properties of hypocrellin A.
Hypocrellin A (HA), an efficient phototherapeutic agent, can chelate with lanthanum ion to form a 1:1 complex, which exhibits enhanced 1O2 generation quantum yield, a red-shifted absorption window, greatly improved water solubility, a much lengthened triplet excited state lifetime, and an increased affinity to DNA with respect to HA. These effects in turn lead to a more potent photodamage ability on calf thymus DNA for La3+-HA than HA in both aerobic and anaerobic conditions, indicating the potential application of La3+-HA in the field of photodynamic therapy (PDT).
Zhou
Jiahong
J
Analysis & Detecting Central, Nanjing Normal University, Nanjing, 210097, People's Republic of China. zhoujiahong72@hotmail.com
Liu
Jihua
J
Xia
Shengqin
S
Wang
Xuesong
X
Zhang
Baowen
B
D000332:Aerobiosis; D000693:Anaerobiosis; D001203:Ascomycota / Q000737:chemistry / Q000378:metabolism; D002614:Chelating Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D004996:Ethidium / Q000737:chemistry; D006900:Hydroxylation; D007811:Lanthanum / Q000737:chemistry*; D049449:Luminescence; D010100:Oxygen / Q000737:chemistry; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry; D019800:Phenol; D010777:Photochemistry; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013481:Superoxides / Q000737:chemistry
D002614:Chelating Agents; D017319:Photosensitizing Agents; D011809:Quinones; D013481:Superoxides; D019800:Phenol; D010569:Perylene; D007811:Lanthanum; D004247:DNA; D004996:Ethidium; D010100:Oxygen; C048388:hypocrellin A