title: [Synthesis and anti-inflammatory activity of hydroxylated E,E-1-(3'-indolyl)-5-(substituted phenyl)-1,4-pentadien-3-one derivatives].
abstract: OBJECTIVE
  A series of new 1,4-pentadien-3-one derivatives were synthesized to search for new Eight novel hydroxylated non-steroidal anti-inflammatory drugs (NSAIDs) with potent activity.
  
  
  METHODS
  E,E-1-(3'-indolyl)-5-( substituted phenyl)-1,4-pentadien-3-one derivatives were synthesized by means of aldol condensation and characterized by 1H NMR, ESI-MS and element analysis. Their anti-inflammatory activity in vitro were evaluated.
  
  
  RESULTS
  Preliminary in vitro pharmacological tests showed that all compounds exhibited anti-inflammatory activity.
  
  
  CONCLUSIONS
  Compounds 4d and 4e exhibited potent anti-inflammatory activity and their anti-inflammatory activity was comparable to resveratrol, and were worthy of further study.
authors.affiliation: Department of Chemistry , University of Science and Technology of China, Hefei.
authors.forename: Xiao-he
authors.initials: XH
authors.lastname: Guo
authors.forename: Sen-xiang
authors.initials: SX
authors.lastname: Cheng
authors.forename: Gui-fang
authors.initials: GF
authors.lastname: Cheng
authors.forename: Jing-xi
authors.initials: JX
authors.lastname: Xie
authors.forename: Jun-biao
authors.initials: JB
authors.lastname: Chang
mesh_terms: D000466:Alkadienes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D000466:Alkadienes; D000893:Anti-Inflammatory Agents; D007211:Indoles; D014409:Tumor Necrosis Factor-alpha