title: Similar effects of general and spinal anaesthesia on perioperative stress response in patients undergoing haemorrhoidectomy.
abstract: Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (n = 7). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-alpha, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-alpha and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.
authors.affiliation: Department of Anaesthesiology and Reanimation, School of Medicine, Kirikkale Univeristy, 71100 Kirikkale, Turkey.
authors.forename: Unase
authors.initials: U
authors.lastname: Buyukkocak
authors.forename: Osman
authors.initials: O
authors.lastname: Caglayan
authors.forename: Cagatay
authors.initials: C
authors.lastname: Daphan
authors.forename: Kuzey
authors.initials: K
authors.lastname: Aydinuraz
authors.forename: Oral
authors.initials: O
authors.lastname: Saygun
authors.forename: Fatih
authors.initials: F
authors.lastname: Agalar
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects; D000775:Anesthesia, Spinal / Q000009:adverse effects; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006484:Hemorrhoids / Q000601:surgery*; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein