title: Influence of autonomic nervous dysfunction characterizing effect of diabetes mellitus on heart rate response and exercise capacity in patients undergoing cardiac rehabilitation for acute myocardial infarction.
abstract: BACKGROUND
  The aim of this study was to clarify the influence of sympathetic and parasympathetic nerve (SN and PN) dysfunction on the heart rate (HR) response to exercise and the exercise capacity of patients with acute myocardial infarction (AMI) and diabetes mellitus (DM).
  
  
  RESULTS
  Fifty-two male patients who underwent cardiopulmonary exercise testing (CPX) 1 month after onset of AMI were divided into 2 groups: (DM (+) group, n=20; DM (-) group, n=32). HR, peak oxygen uptake (VO2peak), and plasma norepinephrine (NE) levels were measured during CPX. The high-frequency power (HF) was analyzed by HR variability. The DeltaHR/logDeltaNE obtained from changes of HR and NE from rest to peak exercise and HR change from baseline to the minimum HF (DeltaHRHF) were calculated as parameters of HR response derived from SN and PN activities, respectively. DeltaHR, VO2peak, DeltaHR/logDeltaNE, and DeltaHRHF were significantly lower in the DM (+) group than in the DM (-) group, and both of them showed positive correlations with VO2peak.
  
  
  CONCLUSIONS
  An inadequate HR response to exercise is a major factor causing a decline of exercise capacity, which is derived from both of SN and PN dysfunction, in AMI patients with DM.
authors.affiliation: Department of Rehabilitation Medicine, St Marianna University School of Medicine, Yokohama City Seibu Hospital, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kasahara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Izawa
authors.forename: Kazuto
authors.initials: K
authors.lastname: Omiya
authors.forename: Naohiko
authors.initials: N
authors.lastname: Osada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Masakazu
authors.initials: M
authors.lastname: Saitoh
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Matsunaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Masuda
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000097:blood / Q000503:physiopathology; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology* / Q000534:rehabilitation*; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D009638:Norepinephrine