Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.
A focused library of variously substituted 9-aminoacridine compounds was screened for bioactivity against accumulation of the infectious prion protein isoform, denoted PrP(Sc), in a cell model of prion replication. The efficacy of compounds against PrP(Sc) accumulation was influenced by both substituents of the distal tertiary amine and acridine heterocycle, while cellular cytotoxicity was encoded in the acridine heterocycle substituents.
May
Barnaby C H
BC
Institute for Neurodegenerative Diseases, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA. bmay@ind.ucsf.edu
Witkop
Juanita
J
Sherrill
John
J
Anderson
Marc O
MO
Madrid
Peter B
PB
Zorn
Julie A
JA
Prusiner
Stanley B
SB
Cohen
Fred E
FE
Guy
R Kiplin
RK
D000585:Aminacrine / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009447:Neuroblastoma / Q000473:pathology*; D012608:Scrapie; D013329:Structure-Activity Relationship
D000585:Aminacrine