Relationship of five inflammatory gene polymorphisms with morbidity and mortality in 533 patients admitted to an ICU.
BACKGROUND
The aim of this study was to analyze the association of polymorphisms of five candidate genes with the outcome of consecutive patients admitted to a medical ICU.


METHODS
The study population was prospectively recruited. Inclusion criteria were admission to the ICU and written informed consent by the patients or their relatives. A total of 533 patients were recruited. The morbidity was assessed by SAPS II Score. Outcome data of in hospital mortality and length of ICU and hospital stay were obtained. Genotyping for genetic polymorphisms (CRP 1059, IL1B -511, CTGF -477, CCR2 64VI, IL6 -174) were performed by allele-specific fluorogenic oligonucleotide probes (TaqMan analysis).


RESULTS
All of the investigated polymorphisms were not associated with an altered outcome. There was no difference in morbidity and ICU or in-hospital mortality (neither in cross tabs analysis nor in Kaplan Meier or Cox regression analysis including age, gender and diagnosis as covariates) between the different genotypes.


CONCLUSIONS
Genotyping of the investigated polymorphism for risk stratification of patients admitted to ICU does not seem to be appropriated.
Ortlepp
Jan R
JR
Interdisciplinary Intermediate Care, University Hospital of Aachen-RTWTH, Pauwelsstrasse 30, 52057 Aachen, Germany.
Graf
Jürgen
J
Vesper
Katharina
K
Schmitz
Fabian
F
Mevissen
Vera
V
Sucigan
Sebastian
S
Kersten
Alexander
A
Weber
Christian
C
Janssens
Uwe
U
D000368:Aged; D000483:Alleles; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016896:Treatment Outcome
D016207:Cytokines