[Haloperidol does not alter a choice strategy for reinforcement value in cats].
A blockade of the dopaminergic D1/D2 receptors by systemic administration of haloperidol (0.05-0.5 mg/kg) produced a dose-dependent increase in inhibition of conditioned alimentary behavior in cats under conditions of choice between a valuable delayed reward and a less valuable immediate reward. Administration of haloperidol produced a progressive decrease in the number of effective instrumental reactions, but did not affect the choice between short- and long-latency reactions and their mean latencies. The data obtained do not support a hypothesis that the blockade of dopaminergic receptors shifts behavior towards impulsive reactions. The reasons why the results do not support the hypothesis are discussed.
Kuleshova
E P
EP
Merghanova
G Kh
GKh
Kulikov
M A
MA
Grigor'ian
G A
GA
D000818:Animals; D002415:Cats; D002755:Choice Behavior / Q000502:physiology*; D003216:Conditioning, Operant; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D006220:Haloperidol / Q000494:pharmacology*; D011930:Reaction Time; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D012054:Reinforcement, Psychology; D012201:Reward
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D006220:Haloperidol