Tec kinases in T cell development: a clue behind the mask?
In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmental pathway.
Hogquist
Kristin A
KA
Center for Immunology, University of Minnesota, Minneapolis, 55455, USA.
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology; D011505:Protein-Tyrosine Kinases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*
C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases