title: Iridoids from Neopicrorhiza scrophulariiflora and their hepatoprotective activities in vitro.
abstract: Four new non-glycosidic iridoids, piscrocins D (1), E (2), F (6), and G (7), as well as two new iridoid glycosides, piscrosides A (8) and B (9), were isolated from the roots of Neopicrorhiza scrophulariiflora (Scrophulariaceae), together with seven known iridoids. The structures of the isolated compounds were established by means of 1D and 2D NMR spectroscopy and chemical methods. The hepatoprotective activities of these compounds were evaluated by measuring their effects on CCl(4)-induced hepatocytes damage in vitro, and the structure-activity relationships were also discussed.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P.R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Fei-Hua
authors.initials: FH
authors.lastname: Wu
authors.forename: Fei
authors.initials: F
authors.lastname: Xiong
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Wu
authors.forename: Lu-Yong
authors.initials: LY
authors.lastname: Zhang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Shou-Xun
authors.initials: SX
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D022781:Hepatocytes / Q000187:drug effects*; D039823:Iridoids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D028083:Scrophulariaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D039823:Iridoids; D010936:Plant Extracts