Oncological problems in pancreatic cancer surgery.
Despite the development of more sophisticated diagnostic techniques, pancreatic carcinoma has not yet been detected in the early stage. Surgical resection provides the only chance for cure or long-term survival. The resection rate has increased due to recent advances in surgical techniques and the application of extensive surgery. However, the postoperative prognosis has been poor due to commonly occurring liver metastasis, local recurrence and peritoneal dissemination. Recent molecular-biological studies have clarified occult metastasis, micrometastasis and systemic disease in pancreatic cancer. Several oncological problems in pancreatic cancer surgery are discussed in the present review.
Nakao
Akimasa
A
Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. nakaoaki@med.nagoya-u.ac.jp
Fujii
Tsutomu
T
Sugimoto
Hiroyuki
H
Kanazumi
Naohito
N
Nomoto
Shuji
S
Kodera
Yasuhiro
Y
Inoue
Soichiro
S
Takeda
Shin
S
D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D015994:Incidence; D008207:Lymphatic Metastasis / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D009361:Neoplasm Invasiveness / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control; D009367:Neoplasm Staging; D010179:Pancreas / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant