Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis.
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome which can be an inherited congenital disorder or can develop secondary to malignancy, infection, or autoimmune disease. Secondary HLH due to malignancy occurs most commonly with T or NK-cell lymphoid neoplasms. HLH with B-cell malignancies is less common and HLH has rarely been described in association with precursor B-cell acute lymphoblastic leukemia (B-ALL). We report three cases of HLH associated with B-ALL and review 17 cases of ALL-associated HLH previously reported in the literature.
O'Brien
Maureen M
MM
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA.
Lee-Kim
Youngna
Y
George
Tracy I
TI
McClain
Kenneth L
KL
Twist
Clare J
CJ
Jeng
Michael
M
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000276:immunology; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000276:immunology