title: Benefit of "one-stage full-mouth disinfection" is explained by disinfection and root planing within 24 hours: a randomized controlled trial.
abstract: OBJECTIVE
  The beneficial effects of the one-stage, full-mouth disinfection remain controversial in the scientific literature. This might be due to the fact that an entire mouth disinfection with the use of antiseptics has been confused with a full-mouth scaling and root planing. This parallel, single blind RCT study aimed to compare several full-mouth treatment strategies with each other.
  
  
  METHODS
  Seventy-one patients with moderate periodontitis were randomly allocated to one of the following treatment strategies: scaling and root planing, quadrant by quadrant, at two-week intervals (negative control, NC), full-mouth scaling and root planing within 2 consecutive days (FRP), or three one-stage, full-mouth disinfection (FM) protocols within 2 consecutive days applying antiseptics to all intra-oral niches for periopathogens using as antiseptics: chlorhexidine (FMCHX) for 2 months, amine fluoride/stannous fluoride for 2 months (FMF), or chlorhexidine for 2 months followed by amine fluoride/stannous fluoride for another 6 months (FMCHX+F). At baseline and after 2, 4, and 8 a series of periodontal parameters were recorded.
  
  
  RESULTS
  All treatment strategies resulted in significant (p<0.05) improvements of all clinical parameters over the entire duration of the study. Inter-treatment differences were often encountered. The NC group nearly always showed significant smaller improvements than the two CHX groups. The differences between the FRP or FM groups, and the two CHX groups only sporadically reached a statistical significance.
  
  
  CONCLUSIONS
  These observations indicate that the benefits of the "OSFMD" protocol are partially due to the use of the antiseptics and partially to the completion of the therapy in a short time.
authors.affiliation: Department of Periodontology, Faculty of Medicine, Catholic University of leuven, Leuven, Belgium. Marc.Quirynen@med.kuleuven.ac.be
authors.forename: Marc
authors.initials: M
authors.lastname: Quirynen
authors.forename: Marc
authors.initials: M
authors.lastname: De Soete
authors.forename: Geert
authors.initials: G
authors.lastname: Boschmans
authors.forename: Martine
authors.initials: M
authors.lastname: Pauwels
authors.forename: Wim
authors.initials: W
authors.lastname: Coucke
authors.forename: Wim
authors.initials: W
authors.lastname: Teughels
authors.forename: Daniel
authors.initials: D
authors.lastname: van Steenberghe
mesh_terms: D000328:Adult; D000368:Aged; D000588:Amines / Q000008:administration & dosage / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use; D003773:Dental Plaque / Q000628:therapy; D012534:Dental Scaling; D004203:Disinfection / Q000379:methods*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000628:therapy; D005891:Gingivitis / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D009067:Mouthwashes / Q000627:therapeutic use; D017622:Periodontal Attachment Loss / Q000628:therapy; D010514:Periodontal Pocket / Q000628:therapy; D010518:Periodontitis / Q000628:therapy*; D016745:Root Planing; D016037:Single-Blind Method; D014002:Tin Fluorides / Q000008:administration & dosage / Q000627:therapeutic use; D014075:Tooth Discoloration / Q000139:chemically induced
chemical_list: D000588:Amines; D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009067:Mouthwashes; D014002:Tin Fluorides; C059813:Meridol; D002710:Chlorhexidine