CpNifS-dependent iron-sulfur cluster biogenesis in chloroplasts.
Iron-sulfur (Fe-S) clusters are important prosthetic groups in all organisms. The biosynthesis of Fe-S clusters has been studied extensively in bacteria and yeast. By contrast, much remains to be discovered about Fe-S cluster biogenesis in higher plants. Plant plastids are known to make their own Fe-S clusters. Plastid Fe-S proteins are involved in essential metabolic pathways, such as photosynthesis, nitrogen and sulfur assimilation, protein import, and chlorophyll transformation. This review aims to summarize the roles of Fe-S proteins in essential metabolic pathways and to give an overview of the latest findings on plastidic Fe-S assembly. The plastidic Fe-S biosynthetic machinery contains many homologues of bacterial mobilization of sulfur (SUF) proteins, but there are additional components and properties that may be plant-specific. These additional features could make the plastidic machinery more suitable for assembling Fe-S clusters in the presence of oxygen, and may enable it to be regulated in response to oxidative stress, iron status and light.
Ye
Hong
H
Biology Department, Colorado State University, Fort Collins, CO 80523, USA.
Pilon
Marinus
M
Pilon-Smits
Elizabeth A H
EA
D013437:Carbon-Sulfur Lyases / Q000502:physiology*; D002736:Chloroplasts / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D007506:Iron-Sulfur Proteins / Q000096:biosynthesis* / Q000502:physiology; D010944:Plants / Q000378:metabolism*; D013455:Sulfur / Q000378:metabolism
D007506:Iron-Sulfur Proteins; D013455:Sulfur; D007501:Iron; D013437:Carbon-Sulfur Lyases; C080546:cysteine desulfurase