title: [Natural killer-like T-cell lymphoma/leukemia--a case report and literature review].
abstract: OBJECTIVE
  To identify the clinical and pathological features of natural killer-like T-cell lymphoma/leukemia.
  
  
  METHODS
  The characteristics of natural killer-like T-cell lymphoma/leukemia was discussed with report a new case and review of literatures.
  
  
  RESULTS
  A 16-year-old girl was referred to our hospital because of fever and disseminated cutaneous herpes and ulcer. Atypical lymphoid cells surrounded the dermal vessels with a CD3(+), CD8(+), CD4(-), CD5(-), CD10(-), CD19(-), CD57(-), CD56(+), perforin(+), granzyme B(+) immunophenotype and rearranged T-cell receptor-gamma gene implicated natural killer-like T cell origin. She was treated with prednisone and for several months. Then the patient developed progressive spleen enlargement with overt leukemia, which led to her eventual death.
  
  
  CONCLUSIONS
  Natural killer-like T-cell lymphoma/leukemia is a rare disease with distinctive clinical, histopathologic, and immuno phenotypic characteristics. Current treatment modalities are ineffective for most of the patients.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.
authors.forename: Feng-kui
authors.initials: FK
authors.lastname: Zhang
authors.forename: Hui-jun
authors.initials: HJ
authors.lastname: Wang
authors.forename: Yu-hong
authors.initials: YH
authors.lastname: Wu
authors.forename: Shu-xu
authors.initials: SX
authors.lastname: Dong
authors.forename: Hong-qiang
authors.initials: HQ
authors.lastname: Li
authors.forename: Dong-lin
authors.initials: DL
authors.lastname: Yang
authors.forename: Hui-shu
authors.initials: HS
authors.lastname: Chen
authors.forename: Yu-lin
authors.initials: YL
authors.lastname: Chu
mesh_terms: D000293:Adolescent; D019002:CD56 Antigen / Q000276:immunology; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology*; D015458:Leukemia, T-Cell / Q000276:immunology / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology*
chemical_list: D019002:CD56 Antigen