title: Psychiatric presentation of voltage-gated potassium channel antibody-associated encephalopathy. Case report.
abstract: Voltage-gated potassium channel antibody encephalopathy, a rare cause of limbic encephalopathy, typically presents with memory impairment and seizures. Psychiatric symptoms have not been emphasised in the literature. Here we describe a 58-year-old man who presented with panic attacks and psychogenic non-epileptic seizures and, later on, developed delusions and hallucinations and then confusion. He was found to have antibodies to voltage-gated potassium channels. Treatment with immuno-modulatory therapy resulted in almost complete recovery.
authors.affiliation: Cambridgeshire & Peterborough Mental Health NHS Trust, Cambridge, UK. upartha@hotmail.co.uk
authors.forename: U D
authors.initials: UD
authors.lastname: Parthasarathi
authors.forename: T
authors.initials: T
authors.lastname: Harrower
authors.forename: M
authors.initials: M
authors.lastname: Tempest
authors.forename: J R
authors.initials: JR
authors.lastname: Hodges
authors.forename: C
authors.initials: C
authors.lastname: Walsh
authors.forename: P J
authors.initials: PJ
authors.lastname: McKenna
authors.forename: P C
authors.initials: PC
authors.lastname: Fletcher
mesh_terms: D000906:Antibodies / Q000032:analysis*; D001927:Brain Diseases / Q000276:immunology / Q000523:psychology*; D003221:Confusion / Q000276:immunology / Q000523:psychology / Q000628:therapy; D003702:Delusions / Q000276:immunology / Q000523:psychology / Q000628:therapy; D006212:Hallucinations / Q000276:immunology / Q000523:psychology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000276:immunology* / Q000523:psychology / Q000628:therapy; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D012640:Seizures / Q000276:immunology / Q000523:psychology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D024642:Potassium Channels, Voltage-Gated