Regulating secretory lysosomes.
Secretory lysosomes are lysosomes which are capable of undergoing regulated secretion in response to external stimuli. Many cells of the immune system use secretory lysosomes to release proteins involved in their specialised effector mechanisms. Precisely how lysosomal secretion is regulated in each of these cell types is now the study of much research as these mechanisms control the ability of each of these cells to function. Studies on a number of human genetic diseases have identified some key proteins in controlling secretory lysosome release, and now many interacting partners have been identified. The different regulatory components seem to vary from one cell type to another, providing a multitude of ways for fine tuning the release of secretory lysosomes.
Holt
Oliver J
OJ
Sir William Dunn School of Pathology, South Parks Rd, Oxford OX1 3RE, UK.
Gallo
Federico
F
Griffiths
Gillian M
GM
D033963:Adaptor Protein Complex 3 / Q000172:deficiency; D019883:Alkyl and Aryl Transferases / Q000378:metabolism; D000818:Animals; D002609:Chediak-Higashi Syndrome / Q000235:genetics / Q000503:physiopathology; D022861:Hermanski-Pudlak Syndrome / Q000503:physiopathology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure; D008561:Membrane Fusion / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics; D050600:SNARE Proteins / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology; D033921:Vesicular Transport Proteins / Q000235:genetics; D020691:rab GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology; D000075745:rab27 GTP-Binding Proteins
D033963:Adaptor Protein Complex 3; C102161:LYST protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D050600:SNARE Proteins; C485548:UNC13B protein, human; C507969:UNC13D protein, human; D033921:Vesicular Transport Proteins; D000075745:rab27 GTP-Binding Proteins; D019883:Alkyl and Aryl Transferases; C075607:Rab geranylgeranyltransferase; C066694:RAB27A protein, human; D020691:rab GTP-Binding Proteins