Macrophage Activation Factors<br />in the Brains of AIDS Patients.
HIV, soluble HLA class I (sHLA-I), quinolinic acid (QUIN), and the monokines IL-1&beta;, IL-6, and TNF-&#945; were measured by ELISA and PCR in brain tissue of 60 AIDS autopsies without evidence of CNS opportunistic infections. Individual cases showed good interrogational correlations for the factors measured. There was a positive correlation between concentrations of IL-1&beta; and IL-6. Brain viral burden correlated with intraparenchymal levels of sHLA-I, IL-1&beta;, and IL-6. Comparison of neuritic damage and levels of immune mediators implicates macrophage activation factors in the etiology of neurologic damage in AIDS.
Achim
C L
CL
, Pittsburgh, PA, 15213, United States.
Masliah
E
E
Heyes
M P
MP
Sarnacki
P
P
Hilty
C
C
Baldwin
M
M
Wiley
C A
CA
D015526:AIDS Dementia Complex; D017088:AIDS-Related Opportunistic Infections; D000163:Acquired Immunodeficiency Syndrome; D001921:Brain / Q000276:immunology; D006801:Humans; D008262:Macrophage Activation; D016215:Macrophage-Activating Factors; D009894:Opportunistic Infections; D017378:Quinolinic Acid; D011805:Quinolinic Acids
D016215:Macrophage-Activating Factors; D011805:Quinolinic Acids; D017378:Quinolinic Acid