Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors.
Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.
Farhanullah
Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shinlim-Dong, Seoul 151-742, Republic of Korea.
Kim
Su Yeon
SY
Yoon
Eun-Jeong
EJ
Choi
Eung-Chil
EC
Kim
Sunghoon
S
Kang
Taehee
T
Samrin
Farhana
F
Puri
Sadhna
S
Lee
Jeewoo
J
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008718:Methionine-tRNA Ligase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D015363:Quinolones; D008718:Methionine-tRNA Ligase