Stability-indicating determination of adrenaline in injections containing procaine.
Adrenaline was determined in injections containing procaine in a 1000-fold excess by reversed-phase high-performance liquid chromatography using UV detection at 205 nm and aqueous sulphuric acid (100 micromol/l) as eluent. The relative standard deviation was 2.1%, and the method was selective in the presence of adrenaline degradation products. Changes of the capacity factor with pH and ionic strength of the eluent were studied, and a simple model is suggested to explain the retention data.
Török
I
I
National Institute of Pharmacy, Budapest 5, P.O.B. 450, H-1372 Hungary.
Fekete
J
J
Paál
T L
TL