title: Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma.
abstract: Fatty acid synthase (FAS) is emerging as a potential therapeutic target to treat cancer and obesity. Bioassay-guided fractionation of a MeOH extract of the rhizomes of Dryopteris crassirhizoma (Dryopteridaceae), using an in vitro FAS inhibitory assay, resulted in the isolation of a series of acylphloroglucinols, as the active principles. The isolates 1-10 inhibited FAS with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM. The results of the present study indicate that the acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, 52 Eoun-dong, Yuseong-gu, Daejeon 305-333, Republic of Korea.
authors.forename: MinKyun
authors.initials: M
authors.lastname: Na
authors.forename: JunPil
authors.initials: J
authors.lastname: Jang
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Myung Sun
authors.initials: MS
authors.lastname: Lee
authors.forename: Bo Yeon
authors.initials: BY
authors.lastname: Kim
authors.forename: Won Keun
authors.initials: WK
authors.lastname: Oh
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
mesh_terms: D000215:Acylation; D032492:Dryopteris / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010696:Phloroglucinol / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D010696:Phloroglucinol; D064429:Fatty Acid Synthases