Brown tumor of secondary hyperparathyroidism involving the superior orbit and frontal calvarium.
A 29-year-old white man with chronic renal failure on hemodialysis presented with a subacute onset of painful proptosis, inferior displacement and limited upgaze of his right globe, and a tender, palpable fronto-temporal mass beneath the right scalp. A cranio-orbitotomy was performed to completely excise a large, necrotic, multilocular, cystic, heterogeneous mass. Histopathologic examination with light microscopy demonstrated the characteristic findings of a giant cell tumor. Based on the patient's history of renal failure and laboratory evidence of hyperparathyroidism, a diagnosis of brown tumor was determined.
Zwick
Orin M
OM
Department of Ophthalmic Plastic and Reconstructive Surgery, University of California San Francisco, CA 94143-0344, USA. ozwickmd@yahoo.com
Vagefi
M Reza
MR
Cockerham
Kimberly P
KP
McDermott
Michael W
MW
D000328:Adult; D005094:Exophthalmos / Q000209:etiology; D005624:Frontal Bone; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006435:Renal Dialysis; D012888:Skull Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000209:etiology