Iridoid glycosides from Harpagophytum procumbens D.C. (devil's claw).
Iridoid glycosides, harprocumbide A (6''-O-alpha-D-galactopyranosylharpagoside, 1) and harprocumbide B (6''-O-(cis-p-coumaroyl)-procumbide, 2) were isolated from the tubers of Harpagophytum prucumbens D.C., along with nine known iridoid glycosides 6-O-alpha-D-galactopyranosylharpagoside (3), and harpagoside (4), harpagide (5), 8-cinnamoylmyoporoside (6), 8-O-feruloylhapagide (7), procumbide (8), 6''-O-(p-coumaroyl)-procumbide (9), 8-O-(p-coumaroyl)-harpagide (10) and 8-O-(cis-p-coumaroyl)-harpagide (11). Compound 10 showed marginal inhibition activity against macrophages respiratory burst.
Qi
Jin
J
Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 210009, PR China.
Chen
Ji-Jun
JJ
Cheng
Zhi-Hong
ZH
Zhou
Jia-Hong
JH
Yu
Bo-Yang
BY
Qiu
Samuel X
SX
D000818:Animals; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031684:Harpagophytum / Q000737:chemistry*; D039823:Iridoids / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure
D006027:Glycosides; D039823:Iridoids