Modulation of vascular smooth muscle signaling by reactive oxygen species.
Modulation of signaling in vascular cells by reactive oxygen species (ROS) affects many aspects of cellular function, including growth, migration, and contraction. NADPH oxidases, important sources of ROS, regulate many growth-specific and migration-related signaling pathways. Identifying the precise intracellular targets of ROS enhances understanding of their role in cardiovascular physiology and pathophysiology.
Lyle
Alicia N
AN
Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia, USA.
Griendling
Kathy K
KK
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D002465:Cell Movement / Q000502:physiology; D006321:Heart / Q000254:growth & development / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D017382:Reactive Oxygen Species; D000804:Angiotensin II; D019255:NADPH Oxidases