Small molecules in an RNAi world.
In this Opinion, we compare and contrast small molecules and RNAi. We discuss the advantages and disadvantages of both technologies focusing on timing, specificity, dose and therapeutic use.
Eggert
Ulrike S
US
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. ulrike_eggert@hms.harvard.edu
Field
Christine M
CM
Mitchison
Timothy J
TJ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008954:Models, Biological; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D013997:Time Factors
D034741:RNA, Small Interfering