[Stage-oriented treatment of Lyme borreliosis].
Every manifestation of Lyme borreliosis needs to be treated with antibiotics. The type of antibiotic applied and duration of treatment will depend on the stage and severity of the disease. Erythema migrans, Borrelia lymphocytoma, Lyme arthritis and acrodermatitis chronica atrophicans are primarily treated orally. If neurological symptoms, severe Lyme carditis or eye manifestations are present, intravenous treatment is initially recommended. For oral therapy, doxycycline, amoxicillin, cefuroxime and, if intolerance is shown, azithromycin, are available. For intravenous treatment ceftriaxone, cefotaxime or penicillin G is employed. The overall prognosis for treated Lyme borreliosis is good. However, in particular when manifestations with substantial organic injury have persisted, incomplete healing must be expected. With the exception of erythema migrans, every manifestation should be subjected to a careful diagnostic work-up prior to the start of treatment, because premature antibiotic administration is not only associated with an elevated risk for the patient, but can also mask important diagnostic signs.
Fingerle
V
V
Nationales Referenzzentrum für Borrelien, Max v. Pettenkofer Institut, LMU München. nrz-borrelien@mvp.uni-muenchen.de
Wilske
B
B
D000169:Acrodermatitis / Q000188:drug therapy / Q000209:etiology; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D025065:Borrelia burgdorferi; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D015787:Erythema Chronicum Migrans / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D008193:Lyme Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D020852:Lyme Neuroborreliosis / Q000188:drug therapy; D011379:Prognosis; D011446:Prospective Studies; D019310:Pseudolymphoma / Q000188:drug therapy; D012189:Retrospective Studies; D013997:Time Factors
D000900:Anti-Bacterial Agents