title: Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker.
abstract: Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
authors.affiliation: Psychology Department, University of Central Florida, Orlando, 32816, USA. jbedwell@mail.ucf.edu
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Bedwell
authors.forename: L Stephen
authors.initials: LS
authors.lastname: Miller
authors.forename: James M
authors.initials: JM
authors.lastname: Brown
authors.forename: Nathan E
authors.initials: NE
authors.lastname: Yanasak
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D003118:Color Perception / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010775:Photic Stimulation / Q000379:methods; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014795:Visual Pathways / Q000098:blood supply*
chemical_list: D015415:Biomarkers