title: Lung deposition of continuous and intermittent intravenous ceftazidime in experimental Pseudomonas aeruginosa bronchopneumonia.
abstract: OBJECTIVE
  Lung tissue deposition of intravenous ceftazidime administered either continuously or intermittently was compared in ventilated piglets with experimental bronchopneumonia.
  
  
  METHODS
  Prospective experimental study
  
  
  METHODS
  Eighteen anesthetized and ventilated piglets
  
  
  METHODS
  Bronchopneumonia was produced by the intrabronchial inoculation of Pseudomonas aeruginosa characterized by an impaired sensitivity to ceftazidime (MIC 16 mg/l). Ceftazidime was administered either through a continuous infusion of 90 mg/kg per 24 h after a bolus of 30 mg/kg or by an intermittent infusion of 30 mg/kg per 8 h.
  
  
  RESULTS
  Piglets were killed 24 h after the initiation of continuous ceftazidime (n = 6), and 1 h (peak, n = 6) and 8 h (trough, n = 6) after the third dose following intermittent administration. Lung tissue concentrations of ceftazidime, measured by HPLC, and lung bacterial burden were assessed on multiple postmortem lung specimens. During continuous administration ceftazidime lung tissue concentrations were 9.7 +/- 3.8 microg/g. Following intermittent administration peak and trough lung tissue concentrations were, respectively, 7.1 +/- 2.4 microg/g and 0.6 +/- 1 microg/g. Lung bacterial burden was different after continuous and intermittent administration (median 7.10(3) vs. 4.10(2) cfu/g).
  
  
  CONCLUSIONS
  Continuous infusion of ceftazidime maintained higher tissue concentrations than intermittent administration.
authors.affiliation: Réanimation Chirurgicale Pierre Viars, Department of Anesthesiology, La Pitié-Salpêtrière Hospital, University of Paris VI, 47-83 Boulevard de l'Hôpital, Paris, France.
authors.forename: Cassio
authors.initials: C
authors.lastname: Girardi
authors.forename: Marc
authors.initials: M
authors.lastname: Tonnellier
authors.forename: Ivan
authors.initials: I
authors.lastname: Goldstein
authors.forename: Alfonso
authors.initials: A
authors.lastname: Sartorius
authors.forename: Frederic
authors.initials: F
authors.lastname: Wallet
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Rouby
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001996:Bronchopneumonia / Q000188:drug therapy*; D002442:Ceftazidime / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007262:Infusions, Intravenous / Q000379:methods; D008168:Lung / Q000378:metabolism*; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime