Linkage and association studies of the susceptibility genes for type 2 diabetes.
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by hyperglycemia, insulin resistance, and impaired insulin secretion. T2DM is under strong genetic control. Identification and characterization of genes involved in determining T2DM will contribute to a greater understanding of the pathogenesis of T2DM, and ultimately might lead to the development of better diagnosis, prevention and treatment strategies. Efforts to identify T2DM susceptibility genes have focused on candidate gene approach (association studies) and genome-wide scans (linkage analyses). In this article, we review the current status for mapping and identification of genes for T2DM, with a focus on some promising regions (or genes) and future prospects.
Huang
Qing-Yang
QY
College of Life Science, Central China Normal University, Wuhan 430079, China. huangqy@mail.ccnu.edu.cn
Cheng
Meng-Rong
MR
Ji
Sen-Lin
SL
D001244:Association; D002877:Chromosomes, Human / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D005544:Forecasting; D015894:Genome, Human; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics
D007328:Insulin