[Leu-enkephalin modulates gastric secretion activated by various stimulants].
The results of chronic experiments on dogs showed that leu-enkephalin in doses 1, 7, and 9 microg/kg produced different effects on the gastric secretion and excretion on the background of various stimulants. The maximum protective effect of opiate was produced in a dose of 7 microg/kg. The peptide effect depended on the gastric secretion stimulator used: on the background of carbachol and pentagastrine, the activity of acidic and peptic factors was decreased and the protective factors of gastric juice were increased. In the case of histamine, leu-enkephalin increased the juice acidity and mucus secretion, but decreased the activity of pepsin and the excretion of ammonia from the stomach.
Prosekina
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Tomova
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D000641:Ammonia / Q000378:metabolism; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005765:Gastrointestinal Agents / Q000494:pharmacology; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*
D018712:Analgesics, Non-Narcotic; D005765:Gastrointestinal Agents; D018377:Neurotransmitter Agents; D004743:Enkephalin, Leucine; D000641:Ammonia; D002217:Carbachol; D010434:Pepsin A; D010418:Pentagastrin