Air-stable PinP(O)H as preligand for palladium-catalyzed Kumada couplings of unactivated tosylates.
[reaction: see text] Air-stable and easily accessible PinP(O)H enables highly efficient palladium-catalyzed Kumada cross-coupling reactions of aryl tosylates. The in situ generated catalyst proved applicable not only to electron-rich and electron-poor carbocyclic tosylates but also to heterocyclic tosylates, such as pyridine and quinoline derivatives. The results described herein constitute the first use of air-stable secondary phosphine oxides as preligands for transition-metal-catalyzed coupling reactions between organometallic species and tosylates.
Ackermann
Lutz
L
Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, D-81377 München, Germany. lutz.ackermann@cup.uni-muenchen.de
Althammer
Andreas
A