title: Auditory filter shapes of CBA/CaJ mice: behavioral assessments.
abstract: Auditory filter shape and frequency tuning may be derived by measuring changes in pure tone thresholds as a function of the bandwidth of notched-noise maskers. When these psychophysical methods were applied to CBA/CaJ mice, the resulting filter shapes were well fit by roex(p,r) functions originally developed for human subjects. The equivalent rectangular bandwidths (ERBs) of the filter shapes ranged from 16 to 19% of test frequencies between 8 to 16 kHz. These ERBs correspond well to the performance of humans at high frequencies and the limited number of mammalian species that have been characterized with notched-noise procedures. Frequency tuning was maintained throughout most of the adult lifespan and then showed a selective high-frequency loss at ages beyond 2 years. These results suggest that auditory filtering effects in adult CBA/CaJ mice are similar to normal processes in other mammalian species and provide an excellent model of human presbycusis when they begin to degrade in aging individuals.
authors.affiliation: The Center for Hearing and Balance, Department of Otolarygnology-HNS, Johns Hopkins University, Baltimore, Maryland 21205, USA. bmay@jhu.edu
authors.forename: Bradford J
authors.initials: BJ
authors.lastname: May
authors.forename: Sarah
authors.initials: S
authors.lastname: Kimar
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Prosen
mesh_terms: D000818:Animals; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000502:physiology*; D001522:Behavior, Animal; D003213:Conditioning, Psychological; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D011304:Presbycusis / Q000503:physiopathology*; D011571:Psychoacoustics; D011594:Psychometrics