title: Final height and gonad function after total body irradiation during childhood.
abstract: Short stature and gonad failure can be a side effect of total body irradiation (TBI). The purpose of the study was to evaluate the factors influencing final height and gonad function after TBI. Fifty young adults given TBI during childhood were included. Twenty-seven had been treated with growth hormone (GH). Those given single 10 Grays (Gy) or fractionated 12 Gy TBI had similar characteristics, GH peaks, final heights and gonad function. After the end of GH treatment, 11/20 patients evaluated had GH peak >10 microg/l. Final height was <-2s.d. in 29 (58%). The height loss between TBI and final height (2.4+/-1.1 s.d.) was greater in those who were younger when irradiated (P<0.0001). When the GH-treated and -untreated patients were analyzed separately, this loss was correlated with the age at TBI at 4-8 years for the GH-treated and at 6-8 years for the untreated. Boys showed negative correlations between testicular volume and plasma follicle-stimulating hormone (FSH, P=0.0008) and between plasma FSH and inhibin B (P=0.005) concentrations. We concluded that the indications for GH treatment should be mainly based on the age at irradiation, taking into account the GH peak. The plasma FSH and inhibin B concentrations may predict sperm function.
authors.affiliation: Université Paris-Descartes, Unité d'Endocrinologie Pédiatrique, AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
authors.forename: A-C
authors.initials: AC
authors.lastname: Couto-Silva
authors.forename: C
authors.initials: C
authors.lastname: Trivin
authors.forename: H
authors.initials: H
authors.lastname: Esperou
authors.forename: J
authors.initials: J
authors.lastname: Michon
authors.forename: A
authors.initials: A
authors.lastname: Baruchel
authors.forename: P
authors.initials: P
authors.lastname: Lemaire
authors.forename: R
authors.initials: R
authors.lastname: Brauner
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001827:Body Height / Q000528:radiation effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000097:blood* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D019337:Hematologic Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D019382:Human Growth Hormone / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000097:blood; D008297:Male; D009929:Organ Size / Q000528:radiation effects; D010053:Ovary / Q000254:growth & development / Q000473:pathology / Q000528:radiation effects; D011879:Radiotherapy Dosage; D012737:Sex Factors; D013094:Spermatozoa / Q000378:metabolism / Q000473:pathology; D013737:Testis / Q000254:growth & development* / Q000473:pathology / Q000528:radiation effects; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014916:Whole-Body Irradiation / Q000009:adverse effects*
chemical_list: C422364:inhibin B; D019382:Human Growth Hormone; D007265:Inhibins; D005640:Follicle Stimulating Hormone