title: Prophylaxis of recurrent preeclampsia: low-molecular-weight heparin plus low-dose aspirin versus low-dose aspirin alone.
abstract: OBJECTIVE
  To verify whether prophylaxis with low-molecular-weight heparin (LMWH) and low-dose aspirin (LDA) could positively affect pregnancy outcome in women with a history of severe preeclampsia.
  
  
  METHODS
  We compared 23 pregnancies treated with LDA alone to 31 pregnancies treated with LMWH plus LDA.
  
  
  RESULTS
  Women treated with LMWH-LDA (n = 31) showed a better pregnancy outcome than those treated with LDA alone (n = 23) in terms of gestational age at delivery (p < 0.05), birth weight (p < 0.01), birth weight percentile (p < 0.01), and rate of preeclampsia (p < 0.01). Furthermore, comparing the intra-group outcome variation between previous and index pregnancies, an improvement appeared in each group, but a more pronounced gain was noted in the LMWH-LDA group in terms of gestational age at delivery (p< 0.005), birth weight (p < 0.005), and birth weight percentile (p < 0.005).
  
  
  CONCLUSIONS
  Thromboprophylaxis with LMWH plus LDA can improve pregnancy outcome in women with previous severe preeclampsia.
authors.affiliation: Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, Rome, Italy. s.ferrazzani@rm.unicatt.it
authors.forename: Ferrazzani
authors.initials: F
authors.lastname: Sergio
authors.forename: D'Alessio
authors.initials: D
authors.lastname: Maria Clara
authors.forename: Fatigante
authors.initials: F
authors.lastname: Gabriella
authors.forename: Soreca
authors.initials: S
authors.lastname: Giorgia
authors.lastname: Sara De Carolis
authors.forename: Paradisi
authors.initials: P
authors.lastname: Giancarlo
authors.forename: Caruso
authors.initials: C
authors.lastname: Alessandro
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome; D055502:Secondary Prevention
chemical_list: D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D001241:Aspirin