Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation.
It is well established that interactions of neuropeptides with several cell types at various parts of the intestine are critically involved in intestinal pathophysiology. Among them, neurotensin has been identified as an important mediator in the development and progress of several gastrointestinal functions and disease conditions, exerting its effects by interacting with specific receptors that exert direct and indirect effects on nerves, epithelial cells, and cells of the immune and inflammatory systems. This review summarizes our recent understanding on the participation of neurotensin in the physiology and pathophysiology of the small and large intestine, and discusses various mechanisms that could be involved in these actions.
Zhao
Dezheng
D
Gastrointestinal Neuropeptide Center, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Pothoulakis
Charalabos
C
D000818:Animals; D042783:Endothelial Cells / Q000502:physiology; D005759:Gastroenteritis / Q000209:etiology / Q000503:physiopathology*; D005769:Gastrointestinal Motility / Q000502:physiology; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D008954:Models, Biological; D009496:Neurotensin / Q000502:physiology*; D018028:Receptors, Neurotensin / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology
D018028:Receptors, Neurotensin; D009496:Neurotensin