title: Lipid peroxidation level and antioxidant enzyme activities in the blood of patients with acute and chronic fascioliasis.
abstract: OBJECTIVE
  In this study, we investigated the relationship between fascioliasis and serum malondialdehyde (MDA) levels, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities. We also investigated whether there are significant differences in MDA levels and antioxidant enzymatic activities between acute and chronic fascioliasis.
  
  
  METHODS
  Forty fascioliasis patients who were diagnosed by ES-ELISA positivity were included in this study. The patients were classified as 18 with acute and 22 with chronic fascioliasis.
  
  
  RESULTS
  In patients with fascioliasis, levels of MDA were statistically higher and erythrocyte SOD and GPx activities were statistically lower than in healthy controls. MDA levels were found to be higher in patients with acute fascioliasis than in patients with chronic fascioliasis although MDA levels were significantly higher in patients with chronic fascioliasis than in controls. There was no statistically significant difference between the two groups for the antioxidant enzyme activities.
  
  
  CONCLUSIONS
  The results of this study may indicate that fascioliasis produces specific effects on the antioxidant defense mechanisms due to its inflammatory character. Our results also allow us to suggest that oxidative stress has an important role in the pathogenesis of fascioliasis and the persistence of this oxidative stress can be one of the underlying factors in the pathogenesis of the chronic disease.
authors.affiliation: Department of Microbiology, Medicine Faculty, Suleyman Demirel University, Isparta, Turkey. selcuk@med.sdu.edu.tr
authors.forename: Selçuk
authors.initials: S
authors.lastname: Kaya
authors.forename: Recep
authors.initials: R
authors.lastname: Sütçü
authors.forename: Emel Sesli
authors.initials: ES
authors.lastname: Cetin
authors.forename: Buket Cicioglu
authors.initials: BC
authors.lastname: Aridogan
authors.forename: Namik
authors.initials: N
authors.lastname: Delibaş
authors.forename: Mustafa
authors.initials: M
authors.lastname: Demirci
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D002374:Catalase / Q000097:blood*; D002908:Chronic Disease; D005211:Fascioliasis / Q000097:blood* / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase