title: Murine model of infection by Tropheryma whipplei.
abstract: We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.
authors.affiliation: Unité des Rickettsies, CNRS UMR 6020, Faculté de Médecine, Université de la Méditerranée, 27 Bld. Jean Moulin, 13385 Marseille Cedex 05, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Genot
authors.forename: Andreas
authors.initials: A
authors.lastname: Stein
authors.forename: Hubert
authors.initials: H
authors.lastname: Lepidi
authors.forename: Melanie
authors.initials: M
authors.lastname: Ihrig
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mege
mesh_terms: D000192:Actinomycetales / Q000472:pathogenicity*; D000193:Actinomycetales Infections / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008099:Liver / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D008061:Whipple Disease / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*