Cytotoxic macrocyclic diterpenoid esters from Euphorbia cornigera.
Root extract of Euphorbia cornigera Boiss. (Euphorbiaceae) was separated into seven (compound 1-7) isolates through multiple Craig's distributions and preparative HPLC. The structures and relative configuration of theses compounds were established via spectral analyses as 7,8,12- O-triacetyl-3- O-(2-methylbutanoyl)-ingol (1), 3,8,12- O-triacetyl-7- O-(2-methylbutanoyl = -ingol (2), 3,7,12- O-triacetyl-8- O-(2-methylbutanoyl)-ingol (3), 3,7,8- O-triacetyl-12- O-(2-methylbutanoyl)-ingol (4), 7,12- O-diacetyl-3- O-(2-methylbutanoyl)-8- O-methylingol (5), 3,12- O-diacetyl-7- O-(2-methylbutanoyl)-8- O-methylingol (6) and 3,7- O-diacetyl-12- O-(2-methylbutanoyl)-8- O-methylingol (7). All these compounds, except for 2, are novel metabolites and have not been reported earlier. It has further been demonstrated that all the compounds (1 - 7) are cytotoxic.
Baloch
Imam Bakhsh
IB
Department of Chemistry, Gomal University, Dera Ismail Khan, Pakistan.
Baloch
Musa Kaleem
MK
Saqib
Qazi Najam
QN
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D004952:Esters / Q000737:chemistry; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D007536:Isomerism; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004952:Esters; D010936:Plant Extracts