Prescription of medroxyprogesterone acetate to a patient with pedophilia, resulting in Cushing's syndrome and adrenal insufficiency.
This article provides a case report of a patient with pedophilia who was treated over a 4-year period with medroxyprogesterone acetate (MPA) at a dose of 300 mg/day and as a consequence developed Cushing's Syndrome and adrenal insufficiency, for which he was treated and from which he recovered. He also reported a hypersexual reaction to his own past cessation of MPA. Gonadotropin-releasing hormone agonists, which have a more benign side-effect profile than MPA, are suggested as an alternative to MPA.
Krueger
Richard B
RB
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, and Medical Director, Sexual Behavior Clinic, New York State Psychiatric Institute, Unit #45, 1051 Riverside Drive, New York, NY 10032, USA. rbk1@columbia.edu
Hembree
Wylie
W
Hill
Michael
M
D000309:Adrenal Insufficiency / Q000139:chemically induced*; D000328:Adult; D000374:Aggression / Q000187:drug effects; D003272:Contraceptive Agents, Male / Q000009:adverse effects*; D003480:Cushing Syndrome / Q000139:chemically induced*; D006801:Humans; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects*; D010378:Pedophilia / Q000188:drug therapy* / Q000517:prevention & control; D010913:Pituitary-Adrenal System / Q000187:drug effects
D003272:Contraceptive Agents, Male; D017258:Medroxyprogesterone Acetate