title: Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.
abstract: Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.
authors.affiliation: Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon, 305-600, Republic of Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Ahn
authors.forename: Mi Sik
authors.initials: MS
authors.lastname: Shin
authors.forename: Sun Ho
authors.initials: SH
authors.lastname: Jung
authors.forename: Seung Kyu
authors.initials: SK
authors.lastname: Kang
authors.forename: Kwang Rok
authors.initials: KR
authors.lastname: Kim
authors.forename: Sang Dal
authors.initials: SD
authors.lastname: Rhee
authors.forename: Won Hoon
authors.initials: WH
authors.lastname: Jung
authors.forename: Sung Don
authors.initials: SD
authors.lastname: Yang
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kim
authors.forename: Joo Rang
authors.initials: JR
authors.lastname: Woo
authors.forename: Jeong Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyae Gyeong
authors.initials: HG
authors.lastname: Cheon
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006801:Humans; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D047495:PPAR gamma / Q000819:agonists* / Q000737:chemistry*
chemical_list: C513010:1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester; D007192:Indenes; D008024:Ligands; D047495:PPAR gamma