Endothelial dysfunction in chronic kidney disease: determinant of susceptibility to end-organ damage and therapeutic response.
Endothelial dysfunction (ED) seems to be a crucial mediator of increased cardiovascular risk observed among patients with chronic kidney disease (CKD). Importantly, systemic ED does not only occur in patients with severe renal failure, but also in individuals with earlier stages of CKD. Close association between microalbuminuria and systemic ED renders renal vascular function an important marker for the severity of cardiovascular damage. Furthermore, changes in renal endothelium might be actively involved in the progression of renal end-organ damage. Recently, experimental evidence showed that interindividual variability in endothelial function of healthy rats predicts susceptibility to renal damage and the efficacy of renoprotective treatment. Therefore, a specific manipulation of renal and systemic ED might provide benefits in various stages of CKD. ED thus may represent an ideal therapeutic target not only for treatment, but also for primary prevention of renal disease.
Ochodnicky
Peter
P
Department of Clinical Pharmacology, University Medical Center Groningen (UMCG) and Groningen Institute for Drug Exploration (GUIDE), University of Groningen, Groningen, The Netherlands. p.ochodnicky@med.umcg.nl
Vettoretti
Simone
S
Henning
Robert H
RH
Buikema
Hendrick
H
Van Dokkum
Richard P E
RP
de Zeeuw
Dick
D
D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D004198:Disease Susceptibility; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy