Synthesis and antitumor activity of 1-substituted-2-methyl-5-nitrobenzimidazoles.
Different substituents were introduced in position 1 of 2-methyl-5(6)-nitro-1H-benzimidazole (2) in order to obtain different side chains having different heterocyclic compounds, for example, thiadiazoles (5-7), tetrazoles (8, 9a, b), triazoles (11-13), thiazoles (14a-e), triazines (10, 16, 17), and imidazoles (18a-c). The antitumor effect of compounds 1, 2, 2a, 4, 5, 7, 8, 9a, 10, 13, 14a, 15, 16, and 18c was studied against breast cancer (MCF7) and compounds 2 [IC(50)=4.52 microg] and 7 [IC(50)=8.29 microg] were found to be active.
Ramla
Mostafa M
MM
Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt. ragab118@yahoo.com
Omar
Mohamed A
MA
El-Khamry
Abdel-Momen M
AM
El-Diwani
Hoda I
HI
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D001562:Benzimidazoles