title: Low risk of relapse after achieving undetectable HCG levels in women with partial molar pregnancy.
abstract: OBJECTIVE
  We evaluated the risk of gestational trophoblastic neoplasia (GTN) for women with partial molar pregnancy whose human chorionic gonadotropin (hCG) levels fall spontaneously to undetectable levels using a sensitive hCG assay.
  
  
  METHODS
  We analyzed data from the New England Trophoblastic Disease Center to estimate the risk of GTN among 284 women with partial molar pregnancy and at least 6 months of gonadotropin follow-up.
  
  
  RESULTS
  None of the 238 women with complete gonadotropin follow-up and a spontaneous decline in serum hCG levels to undetectable levels subsequently developed GTN (95% confidence interval 0-1.6%).
  
  
  CONCLUSIONS
  If these results are replicated at other institutions with longstanding experience managing partial molar pregnancies, it may be reasonable to abbreviate clinical follow-up for women with partial molar pregnancy whose serum hCG levels spontaneously decline to an undetectable level.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women's Hospital, Boston, Massachusetts, USA. adam.wolfberg@childrens.harvard.edu
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Wolfberg
authors.forename: Whitfield B
authors.initials: WB
authors.lastname: Growdon
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Feltmate
authors.forename: Donald P
authors.initials: DP
authors.lastname: Goldstein
authors.forename: David R
authors.initials: DR
authors.lastname: Genest
authors.forename: Manuel E
authors.initials: ME
authors.lastname: Chinchilla
authors.forename: Ross S
authors.initials: RS
authors.lastname: Berkowitz
authors.forename: Ellice S
authors.initials: ES
authors.lastname: Lieberman
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D008404:Massachusetts / Q000453:epidemiology; D008499:Medical Records; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D012042:Registries; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000209:etiology
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin