title: Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome.
abstract: We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characterization of a Brazilian DENV-3 strain since its introduction into the country in 2001. DENV-3 was responsible for the most severe dengue epidemic in the state, based on the highest number of reported cases and on the severity of clinical manifestations and deaths reported.
authors.affiliation: Departamento de Virologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, 21040-900, Brasil. marizepm@ioc.fiocruz.br
authors.forename: Marize Pereira
authors.initials: MP
authors.lastname: Miagostovich
authors.forename: Flávia Barreto
authors.initials: FB
authors.lastname: dos Santos
authors.forename: Túlio Machado
authors.initials: TM
authors.lastname: Fumian
authors.forename: Flávia Ramos
authors.initials: FR
authors.lastname: Guimarães
authors.forename: Eliane Veiga
authors.initials: EV
authors.lastname: da Costa
authors.forename: Fernando Neto
authors.initials: FN
authors.lastname: Tavares
authors.forename: Janice Oliveira
authors.initials: JO
authors.lastname: Coelho
authors.forename: Rita Maria Ribeiro
authors.initials: RM
authors.lastname: Nogueira
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D001938:Brazil; D003716:Dengue Virus / Q000235:genetics* / Q000302:isolation & purification; D017809:Fatal Outcome; D005260:Female; D005838:Genotype; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D019595:Severe Dengue / Q000821:virology*
chemical_list: D012367:RNA, Viral