title: Copper(II) complexes of tridentate N,N,N',N'',N''-pentamethyldiethylenetriamine: superoxide dismutase and inhibitory activity against bacteria and fungi.
abstract: A series of ternary copper(II) complexes containing same coordination sphere but difference in the counter ions, viz., [Cu(PMDT)(OAc)]PF(6)(1); [Cu(PMDT)(OAc)]ClO(4)(2); [Cu(PMDT)(OAc)]BF(4)(3) and [Cu(PMDT)(OAc)]BPh(4)(4) where PMDT=N,N,N',N'',N''-pentamethyldiethylenetriamine, OAc=Acetate ion were synthesized and characterized by means of spectroscopic, magnetic and cyclic voltammetric measurements. In frozen solution e.p.r. spectra, an interesting relation g|| >g(perpendicular) has been observed which is atypical of the axially symmetric d(9) Cu(II) (S(Cu)=1/2) having an unpaired electron in a d (x2-y2) orbital. Single crystal X-ray analysis of (1) has revealed the presence of distorted square planar geometry. The influence of the counter ion on the complexes has been examined by performing some biological experiments like superoxide dismutase and anti-microbial activity.
authors.affiliation: Department of Chemistry, A.P.S. University, Rewa (M.P.) 486003, India. rnp64@yahoo.co.uk
authors.forename: R N
authors.initials: RN
authors.lastname: Patel
authors.forename: Nripendra
authors.initials: N
authors.lastname: Singh
authors.forename: V L N
authors.initials: VL
authors.lastname: Gundla
authors.forename: U K
authors.initials: UK
authors.lastname: Chauhan
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D008280:Magnetics; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000494:pharmacology*; D011073:Polyamines / Q000737:chemistry / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D009942:Organometallic Compounds; D011073:Polyamines; C519069:tridentate N,N,N',N'',N''-pentamethyldiethylenetriamine; C005391:diethylenetriamine; D003300:Copper; D013482:Superoxide Dismutase