title: [Necrotizing fasciitis: pathophysiological and clinical aspects of the problem].
abstract: The data of literature and results of treatment of 17 patients with necrotizing fasciitis are analyzed. Original conception of pathogenesis based on thrombosis of microcirculatory vessels of superficial fascia is described. Endotoxemia manifested with clinical picture of sepsis and septic shock. Successful treatment is possible in cases of early diagnosis, urgent surgical treatment and intensive antibiotic therapy. Urgent cryobiopsy of tissues is an important diagnostic point. Lethality was 50% (it reaches 75% according to the literature data), this can be explained by late hospitalization and delayed operation.
authors.forename: M V
authors.initials: MV
authors.lastname: Grinev
authors.forename: O A
authors.initials: OA
authors.lastname: Bud'ko
authors.forename: K M
authors.initials: KM
authors.lastname: Grinev
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D019115:Fasciitis, Necrotizing / Q000382:microbiology / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020246:Venous Thrombosis / Q000503:physiopathology / Q000601:surgery