title: Autophagy in immune defense against Mycobacterium tuberculosis.
abstract: Autophagy is a newly recognized innate and adaptive immunity defense against intracellular pathogens, in keeping with its role as a cytoplasmic maintenance pathway. Induction of autophagy by physiological, pharmacological or immunological means can eliminate intracellular Mycobacterium tuberculosis, providing one of the first examples of the immunological role of autophagy. Under normal circumstances, M. Tuberculosis survives in macrophages by inhibiting phagolysosome biogenesis. Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated.
authors.affiliation: Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-001, USA. vderetic@salud.unm.edu
authors.forename: Isabelle
authors.initials: I
authors.lastname: Vergne
authors.forename: Sudha
authors.initials: S
authors.lastname: Singh
authors.forename: Esteban
authors.initials: E
authors.lastname: Roberts
authors.forename: George
authors.initials: G
authors.lastname: Kyei
authors.forename: Sharon
authors.initials: S
authors.lastname: Master
authors.forename: James
authors.initials: J
authors.lastname: Harris
authors.forename: Sergio
authors.initials: S
authors.lastname: de Haro
authors.forename: John
authors.initials: J
authors.lastname: Naylor
authors.forename: Alex
authors.initials: A
authors.lastname: Davis
authors.forename: Monica
authors.initials: M
authors.lastname: Delgado
authors.forename: Vojo
authors.initials: V
authors.lastname: Deretic
mesh_terms: D001343:Autophagy / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000502:physiology; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology; D008055:Lipids / Q000502:physiology; D008264:Macrophages / Q000382:microbiology; D050296:Microbial Viability; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity*; D010587:Phagocytosis / Q000502:physiology; D010588:Phagosomes / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000096:biosynthesis; D018418:Th2 Cells / Q000378:metabolism / Q000502:physiology; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D016207:Cytokines; D008055:Lipids; D018129:Phosphatidylinositol Phosphates; C055525:phosphatidylinositol 3-phosphate; D007371:Interferon-gamma; D020558:GTP Phosphohydrolases