title: Hierarchical classification of hydrolases catalytic sites.
abstract: Universal ontology of catalytic sites is required to systematize enzyme catalytic sites, their evolution as well as relations between catalytic sites and protein families, organisms and chemical reactions. Here we present a classification of hydrolases catalytic sites based on hierarchical organization. The web-accessible database provides information on the catalytic sites, protein folds, EC numbers and source organisms of the enzymes and includes software allowing for analysis and visualization of the relations between them.
  
  
  BACKGROUND
  http://www.enzyme.chem.msu.ru/hcs/
authors.affiliation: School of Enzymology, Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119992, Russia. gariev@hotmail.com
authors.forename: Igor A
authors.initials: IA
authors.lastname: Gariev
authors.forename: Sergey D
authors.initials: SD
authors.lastname: Varfolomeev
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D002384:Catalysis; D003198:Computer Simulation; D003628:Database Management Systems; D030562:Databases, Protein; D004789:Enzyme Activation; D006867:Hydrolases / Q000737:chemistry* / Q000145:classification*; D016247:Information Storage and Retrieval / Q000379:methods; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D014584:User-Computer Interface
chemical_list: D006867:Hydrolases