Chorea induced by globus pallidus externus stimulation in a dystonic patient.
Bilateral high-frequency stimulation of the internal part of the pallidum has proven its efficacy in improving motor symptoms of dystonia. In Parkinson's disease, the stimulation of the external pallidum (GPe) can induce dyskinesias. This has never been described in dystonia. We report here a case of abnormal movements induced by the stimulation of GPe in a dystonic patient and discuss the pathophysiological mechanisms.
Mouton
Servane
S
Service de Neurologie C, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Claude Bernard Lyon I University, INSERM U 534, Lyon, France.
Xie-Brustolin
Jing
J
Mertens
Patrick
P
Polo
Gustavo
G
Damier
Philippe
P
Broussolle
Emmanuel
E
Thobois
Stéphane
S
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002819:Chorea / Q000209:etiology* / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D004292:Dominance, Cerebral / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000628:therapy*; D004421:Dystonia / Q000139:chemically induced* / Q000628:therapy*; D004567:Electrodes, Implanted; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D016896:Treatment Outcome
D014150:Antipsychotic Agents