title: Primary mucinous carcinoma with direct histopathologic evidence of lymphatic invasion.
abstract: BACKGROUND
  Primary mucinous carcinoma of the skin is a rare sweat gland neoplasm which occurs most commonly in the periorbital region. Although the tumor has a propensity for local recurrence and regional spread, distant metastases are rare. The standard treatment of primary mucinous carcinoma is wide local excision. Mohs micrographic surgery may also be utilized in cases where tissue conservation is of utmost concern.
  
  
  OBJECTIVE
  We present a case of primary mucinous carcinoma arising in the scalp, which was treated with wide local excision.
  
  
  METHODS
  A case report and literature review are presented.
  
  
  RESULTS
  Histopathologic evaluation revealed a well-circumscribed neoplasm characterized by lobules and aggregates of epithelial cells embedded in abundant pools of mucin. In addition, small aggregates of neoplastic cells were found at a distance from the primary nodule, indicative of lymphatic invasion.
  
  
  CONCLUSIONS
  Primary mucinous carcinoma has a high propensity for locoregional metastases and recurrence. To our knowledge, this is the first report demonstrating direct histopathologic evidence of lymphatic invasion which correlates with this tumor's biologic behavior.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University Medical Center, New York, NY, USA.
authors.forename: Melanie
authors.initials: M
authors.lastname: Warycha
authors.forename: Hideko
authors.initials: H
authors.lastname: Kamino
authors.forename: Narciss
authors.initials: N
authors.lastname: Mobini
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Hale
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000601:surgery; D001706:Biopsy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery