The role of neurotensin in central nervous system pathophysiology: what is the evidence?
The peptide neurotensin has been studied for more than 30 years. Although it is widely distributed in the central and peripheral nervous systems, neurotensin has been more intensely studied with regard to its interactions with the central dopamine system. A number of claims have been made regarding its possible implication in many diseases of the central nervous system, including schizophrenia. In this review, we describe briefly the basic biology of this neuropeptide, and then we consider the strengths and the weaknesses of the data that suggest a role for neurotensin in schizophrenia, drug abuse, Parkinson's disease, pain, central control of blood pressure, eating disorders, cancer, neurodegenerative disorders and inflammation.
St-Gelais
Fannie
F
Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montréal, Quebec.
Jomphe
Claudia
C
Trudeau
Louis-Eric
LE
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism / Q000502:physiology; D002490:Central Nervous System / Q000503:physiopathology*; D002493:Central Nervous System Diseases / Q000503:physiopathology*; D006801:Humans; D009496:Neurotensin / Q000096:biosynthesis / Q000502:physiology*; D010146:Pain / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology; D012559:Schizophrenia / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000503:physiopathology; D009435:Synaptic Transmission
D015306:Biogenic Monoamines; D009496:Neurotensin