title: Determination of carbisocaine, heptacaine and pentacaine in plasma by capillary gas chromatography with nitrogen-selective detection.
abstract: A gas-liquid chromatographic method is described for the determination of the local anaesthetics carbisocaine, heptacaine and pentacaine in plasma. A C(18) solid-phase extraction was used in a modification to increase selectivity. Following on-column derivatization with trimethylanilinium hydroxide, the analytes were determined by means of capillary gas chromatography and nitrogen-phosphorus selective detection. In comparison with flame ionization detection, the sensitivity of NPD was 20 times higher with a limit of determination in plasma of 10 ng ml(-1).
authors.affiliation: Department of Analytical Chemistry and Toxicology, State University, Deusinglaan 2, 9713 AW Groningen, The Netherlands.
authors.forename: V
authors.initials: V
authors.lastname: Marko
authors.forename: J
authors.initials: J
authors.lastname: Wijsbeek
authors.forename: R A
authors.initials: RA
authors.lastname: De Zeeuw