Correction of massive hydrocephalus and brain wound in holoprosencephaly.
Holoprosencephaly is a rare disorder of embryologic development that denotes an incomplete or absent division of the embryonic forebrain (prosencephalon) into distinct lateral cerebral hemispheres. In most cases of holoprosencephaly, the fetus fails to survive to term, and those that do survive have severe functional limitations, including mental retardation. We present a case report of cranial vault remodeling in a 20-month-old female who was born with holoprosencephaly and a severe number 0/14 cleft. The patient developed chronic nonhealing ulcers secondary to hydrocephalus, ventriculoperitoneal shunts, and the underlying architecture of her cranial vault.
Dickinson
Brian P
BP
Division of Plastic and Reconstructive Surgery, University of California Los Angeles (UCLA) School of Medicine, Los Angeles, California 90095-6960, USA.
Spoon
Daniel B
DB
Cordray
Tracy L
TL
Lazareff
Jorge
J
Wasson
Kristy
K
Bradley
James P
JP
D020341:Absorbable Implants; D001860:Bone Plates; D016025:Bone Transplantation; D003399:Craniotomy; D005260:Female; D016142:Holoprosencephaly / Q000150:complications / Q000601:surgery*; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000601:surgery*; D007223:Infant; D019651:Plastic Surgery Procedures / Q000379:methods; D012883:Skin Ulcer / Q000209:etiology; D012886:Skull / Q000002:abnormalities / Q000601:surgery*; D017287:Ventriculoperitoneal Shunt