Spatiotemporal changes of the herpes simplex virus entry receptor nectin-1 in murine brain during postnatal development.
Herpes simplex virus (HSV) is known to replicate within the limbic system and to alter behavior in both humans and experimental animals. However, the reason why the virus selectively damages this anatomical, developmental, and functional neural unit remains a mystery. Nor is it known why herpes simplex encephalitis fails to respect these neuroanatomical boundaries in newborns. In the present study, the authors determined the spatiotemporal changes in the distribution of the major neural entry receptor for HSV (nectin-1) in postnatal mouse and rat brains. Discrete nectin-1 immunopositivity was observed in regions susceptible to HSV infection in specific developmental phases of central nervous system. The authors also describe nectin-1-related pathways controlling neuronal cell migration/brain morphogenesis, the disruption of which might lead to the emergence of mental disorders with a rapid cognitive decline.
Horváth
Szatmár
S
Department of Psychiatry, Faculty of Medicine, University of Szeged, Szeged, Hungary. szatmar@nepsy.szote.u-szeged.hu
Prandovszky
Emese
E
Kis
Zsolt
Z
Krummenacher
Claude
C
Eisenberg
Roselyn J
RJ
Cohen
Gary H
GH
Janka
Zoltán
Z
Toldi
József
J
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002455:Cell Division; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D003337:Corpus Callosum / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D004198:Disease Susceptibility; D020803:Encephalitis, Herpes Simplex / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D008032:Limbic System / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D000075983:Nectins; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism; D011247:Pregnancy; D011991:Receptors, Virus / Q000378:metabolism*; D012794:Sialic Acids / Q000378:metabolism; D018139:Simplexvirus / Q000378:metabolism*
D015815:Cell Adhesion Molecules; C000619010:NECTIN1 protein, human; C000619015:Nectin1 protein, mouse; D000075983:Nectins; D039842:Neural Cell Adhesion Molecule L1; D011991:Receptors, Virus; D012794:Sialic Acids; C103469:polysialyl neural cell adhesion molecule