Induction of salivary antibodies to inhibit Candida albicans adherence to human epithelial cells by tonsillar immunization in rabbits.
To examine the possibility of a vaccine for Candida albicans infection in the oral cavity, we induced salivary antibodies by immunization of killed-C. albicans ATCC 18804 on the palatine tonsils of rabbits. The enzyme-linked immunosorbent assay reaction of salivary antibodies was high against C. albicans serotype A. The saliva antibodies greatly inhibited C. albicans adherence to cloned epithelial cells from human gingiva. Tonsillar immunizations of C. albicans ATCC 18804 induce salivary antibodies that prevent C. albicans adherence to epithelial cells, and thus should prove useful in the prevention of oral candidiasis caused by C. albicans serotype A.
Fukuizumi
Takaki
T
Division of Infections and Molecular Biology, Kyushu Dental College, Kitakyushu, Japan.
Nagamatsu
Hiroshi
H
Kojo
Tatsuro
T
Inoue
Hiromasa
H
D000818:Animals; D000908:Antibodies, Fungal / Q000096:biosynthesis / Q000276:immunology*; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology; D002176:Candida albicans / Q000276:immunology* / Q000502:physiology; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D004797:Enzyme-Linked Immunosorbent Assay; D005881:Gingiva / Q000166:cytology; D006801:Humans; D007114:Immunization / Q000379:methods*; D014066:Palatine Tonsil / Q000276:immunology*; D011817:Rabbits; D012463:Saliva / Q000276:immunology*
D000908:Antibodies, Fungal; D000941:Antigens