[Clinical study of deoxyribonucleotidum for adjuvant treatment of pulmonary tuberculosis with hepatic lesion].
OBJECTIVE
To evaluate of therapeutic efficacy of deoxyribouncleotidum on pulmonary tuberculosis.


METHODS
Eighty patients with pulmonary tuberculosis sustaining hepatic lesion after treatment with antituberculosis drugs were randomized into therapeutic group and control group. Patients in the control group received regular treatment and those in the therapeutic group had additional deoxyribouncleotidum injection.


RESULTS
ALT, AST, ALP and TBIL levels were significantly higher in the therapeutic group than in the control group 4 weeks after treatment. IgG, IgA, IgM levels, and CD3(+) and CD8(+) lymphocytes were significantly increased in the therapeutic group after treatment (P<0.05).


CONCLUSIONS
deoxyribouncleotidum can improve hepatic function and immunity in patients with pulmonary tuberculosis.
Chen
Yong-hao
YH
Sixth Division, Department of Internal Medicine, Guangzhou Municipal Hospital of Chest Medicine, Guangzhou 510095, China.
Chen
Zhi-cheng
ZC
Chen
Qing-xin
QX
Lin
Qing-yu
QY
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000378:metabolism; D017252:CD3 Complex / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D056486:Chemical and Drug Induced Liver Injury; D003854:Deoxyribonucleotides / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007267:Injections; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy*
D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D017252:CD3 Complex; D003854:Deoxyribonucleotides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase