title: Clinical symptoms and the odds of human T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: application of best-fit logistic regression equation based on host genotype, age, and provirus load.
abstract: The authors have previously developed a logistic regression equation to predict the odds that a human T-cell lymphotropic virus type 1 (HTLV-1)-infected individual of specified genotype, age, and provirus load has HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in southern Japan. This study evaluated whether this equation is useful predictor for monitoring asymptomatic HTLV-1-seropositive carriers (HCs) in the same population. The authors genotyped 181 HCs for each HAM/TSP-associated gene (tumor necrosis factor [TNF]-alpha-863A/C, stromal cell-derived factor 1 (SDF-1) +801G/A, human leukocyte antigen [HLA]-A*02, HLA-Cw*08, HTLV-1 tax subgroup) and measured HTLV-1 provirus load in peripheral blood mononuclear cells using real-time polymerase chain reaction (PCR). Finally, the odds of HAM/TSP for each subject were calculated by using the equation and compared the results with clinical symptoms and laboratory findings. Although no clear difference was seen between the odds of HAM/TSP and either sex, family history of HAM/TSP or adult T-cell lenkemia (ATL), history of blood transfusion, it was found that brisk patellar deep tendon reflexes, which suggest latent central nervous system compromise, and flower cell-like abnormal lymphocytes, which is the morphological characteristic of ATL cells, were associated with a higher odds of HAM/TSP. The best-fit logistic regression equation may be useful for detecting subclinical abnormalities in HCs in southern Japan.
authors.affiliation: Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Nose
authors.forename: Mineki
authors.initials: M
authors.lastname: Saito
authors.forename: Koichiro
authors.initials: K
authors.lastname: Usuku
authors.forename: Amir H
authors.initials: AH
authors.lastname: Sabouri
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kubota
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Eiraku
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Shuji
authors.initials: S
authors.lastname: Izumo
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Osame
mesh_terms: D000328:Adult; D017677:Age Distribution; D002353:Carrier State / Q000453:epidemiology*; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D015368:Human T-lymphotropic virus 1; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D016017:Odds Ratio; D015493:Paraparesis, Tropical Spastic / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D011237:Predictive Value of Tests; D011533:Proviruses; D012372:ROC Curve; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D019562:Viral Load
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D015234:HLA-A Antigens; D015236:HLA-C Antigens; D014409:Tumor Necrosis Factor-alpha