Asymmetric allylboration of cyclic imines and applications to alkaloid synthesis.
Treatment of cyclic imines with 3,3'-disubstituted binaphthol modified allylboronates provides the expected allylated products in good yields and with high stereoselectivities (91-99% ee). The products may be readily transformed into various alkaloids.
Wu
T Robert
TR
Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
Chong
J Michael
JM