T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities.
Cytogenetic data for T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) are scarcely available. We report here a case of THRLBCL with a near-tetraploid karyotype and complex chromosomal aberrations, without rearrangement of BCL2 or BCL6, and characterized pathologically by a variegated morphologic appearance with areas resembling nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL).
de Leval
Laurence
L
Department of Pathology, CHU Sart-Tilman, Liege, Belgium. L.deLeval@ulg.ac.be
Harris
Nancy Lee
NL
Lampertz
Serge
S
Herens
Christian
C
D002869:Chromosome Aberrations; D006644:Histiocytes / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D013601:T-Lymphocytes / Q000473:pathology*