[Astressin blockade of amygdaloid corticoliberin receptors eliminates the stimulating effects of amphetamine, morphine and leu-enkephalin on brain self-stimulation].
Amphetamine (1 mg/kg), morphine (1 mg/kg), and ethaminal sodium (5 mg/kg) activated self-stimulation reaction of lateral hypothalamus in rats. In contrast, intraamygdalary injections of astressin (1 microg/microl), which is a nonselective antagonist of corticoliberin receptors, inhibited this reaction. The astressin blockade of extrahypothalamic corticoliberin receptors in the central nucleus of amygdala modified the effects of various narcogens on self-stimulation reaction. On this background, amphetamine did not activate self-stimulation, ethaminal sodium retained significant psychoactivating effect, whereas the effect of morphine switched from stimulant to depressant. Leu-enkephalin exhibited a stable depressant effect, thus potentiating the action of astressin. The astressin-induced enhancement of the inhibiting action of leu-enkephalin on cerebral self-stimulation is probably related to a temporary switch-off of the activating influence of the central nucleus of amygdala on hypothalamus.
Shabanov
P D
PD
Lebedev
A A
AA
Voevodin
E E
EE
Strel'tsov
V F
VF
D000200:Action Potentials / Q000187:drug effects; D000661:Amphetamine / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004743:Enkephalin, Leucine; D007026:Hypothalamic Area, Lateral / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism; D012653:Self Stimulation / Q000187:drug effects*
D000701:Analgesics, Opioid; D000697:Central Nervous System Stimulants; D018696:Neuroprotective Agents; D018377:Neurotransmitter Agents; D010446:Peptide Fragments; D018019:Receptors, Corticotropin-Releasing Hormone; C104416:astressin; D004743:Enkephalin, Leucine; D009020:Morphine; D003346:Corticotropin-Releasing Hormone; D000661:Amphetamine