title: Eosinophil-selective mediators in human strongyloidiasis.
abstract: Strongyloides stercoralis infection is characterized by the production of IgE and eosinophils in peripheral blood. Experimental studies have demonstrated that eosinophils play an important role in protection against Strongyloides stercoralis, but the mechanisms regulating eosinophils are not known. In this study we have focused on analysing the molecules that selectively regulate eosinophil migration, namely eotaxin and interleukin-5 (IL-5), using an enzyme-linked immunosorbent assay in patients with strongyloidiasis. Serum expression of eotaxin and IL-5 were significantly increased in patients compared with the control group. This rise suggests that selective mediators of the eosinophil can have a role in immunity against S. stercoralis in human infection.
authors.affiliation: Department of Medicine, University of Valencia, Spain. amparo.mir@uv.es
authors.forename: A
authors.initials: A
authors.lastname: Mir
authors.forename: D
authors.initials: D
authors.lastname: Benahmed
authors.forename: R
authors.initials: R
authors.lastname: Igual
authors.forename: R
authors.initials: R
authors.lastname: Borrás
authors.forename: J E
authors.initials: JE
authors.lastname: O'Connor
authors.forename: M J
authors.initials: MJ
authors.lastname: Moreno
authors.forename: S
authors.initials: S
authors.lastname: Rull
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000097:blood* / Q000276:immunology; D002634:Chemotaxis, Leukocyte; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D015848:Interleukin-5 / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D017171:Strongyloides stercoralis / Q000276:immunology*; D013322:Strongyloidiasis / Q000276:immunology* / Q000469:parasitology
chemical_list: D000909:Antibodies, Helminth; C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D015848:Interleukin-5; D007073:Immunoglobulin E