Synthesis and reactivity of imide-derived bisvinyl phosphates. Reactivity of 2,6-disubstituted 1,4-dihydropyridines.
Symmetrical and unsymmetrical 2,6-disubstituted dihydropyridines were prepared in high yields under mild conditions using the Suzuki and Stille Pd-catalyzed coupling reactions of imide-derived bisvinyl phosphates with a range of aryl, heteroaryl, and alkenyl moieties. The alkylation reaction at C-4 easily afforded original tri- and tetrasubstituted dihydropyridines. Hydrolysis of the latter under acidic condition provided efficiently either open-chain 1,5-diketones or di- or trisubstituted pyridines.
Mousset
Deborah
D
ICOA, UMR 6005, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France.
Gillaizeau
Isabelle
I
Sabatié
Andréa
A
Bouyssou
Pascal
P
Coudert
Gérard
G