title: Seroepidemiology of hepatitis B virus infection and high rate of response to hepatitis B virus Butang vaccine in adolescents from low income families in Central Brazil.
abstract: In order to evaluate the seroepidemiology and response to Butang vaccine in adolescents from low income families in Central Brazil, blood samples of 664 adolescents were tested for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc), and hepatitis B surface antibody (anti-HBs) markers, and multiple logistical regression analysis was carried out to determine variables associated with hepatitis B virus (HBV) infection markers. further, three 20 microg Butang vaccine doses were offered to all susceptible individuals (n = 304). Among those who accepted them (n = 182), the seroresponse was evaluated in 170 individuals by quantitative anti-HBs. an overall hbv prevalence of 5.9% was found: four adolescents were HBsAg positive, 24 were anti-HBc, anti-HBs-reactive, and 11 were anti-HBc only. The analyse of risk factors showed that age 16-19 years, place of birth outside Goiás, school B and body piercing were statistically associated with HBV infection markers (p < 0.05). All 170 adolescents responded to Butang, and a geometric mean titer (gmt) of 4344 mUI/ml was obtained. these results reinforce the importance of hepatitis b vaccine in adolescents despite of the hbv regional endemicity, and suggest that three doses of 20 microg of the Butang should guarantee protective anti-hbs levels to individuals at a critical time for hepatitis b acquiring such as latter adolescence and adulthood.
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Goiás, Goiânia, GO, 74605-080, Brasil.
authors.forename: Michele Dias da S
authors.initials: MD
authors.lastname: Oliveira
authors.forename: Regina M B
authors.initials: RM
authors.lastname: Martins
authors.forename: Marcos A
authors.initials: MA
authors.lastname: Matos
authors.forename: Renata C
authors.initials: RC
authors.lastname: Ferreira
authors.forename: Márcia A
authors.initials: MA
authors.lastname: Dias
authors.forename: Megmar A S
authors.initials: MA
authors.lastname: Carneiro
authors.forename: Ana Luiza N
authors.initials: AL
authors.lastname: Junqueira
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Teles
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood*; D006512:Hepatitis B Core Antigens / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D011203:Poverty; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines