Human ABC transporter ABCG2 in xenobiotic protection and redox biology.
Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is regarded as a member of the phase III system of xenobiotic metabolism. This efflux pump is suggested to be responsible for protecting the body from toxic xenobiotics and for removing toxic metabolites. The aim of this review article is to address new aspects of ABCG2 related to redox biology, namely the posttranslational modification (intra- and intermolecular disulfide bond formation) of ABCG2 protein and the transport of porphyrin and chlorophyll metabolites, as well as the high-speed screening and QSAR analysis method to evaluate ABCG2-drug interactions.
Wakabayashi
Kanako
K
Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology, Yokohama, Japan.
Tamura
Ai
A
Saito
Hikaru
H
Onishi
Yuko
Y
Ishikawa
Toshihisa
T
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D002734:Chlorophyll / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D011166:Porphyrins / Q000378:metabolism; D015262:Xenobiotics / Q000008:administration & dosage / Q000378:metabolism*
C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D009363:Neoplasm Proteins; D011166:Porphyrins; D015262:Xenobiotics; D002734:Chlorophyll