Enantioselective reduction of ketones with "designer cells" at high substrate concentrations: highly efficient access to functionalized optically active alcohols.
Gröger
Harald
H
Degussa AG, Service Center Biocatalysis, P.O. Box 1345, 63403 Hanau, Germany. harald.groeger@degussa.com
Chamouleau
Francoise
F
Orologas
Nicolas
N
Rollmann
Claudia
C
Drauz
Karlheinz
K
Hummel
Werner
W
Weckbecker
Andrea
A
May
Oliver
O
D000426:Alcohol Dehydrogenase / Q000737:chemistry* / Q000235:genetics; D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D042843:Glucose 1-Dehydrogenase / Q000737:chemistry* / Q000235:genetics; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
D000438:Alcohols; D007659:Ketones; D000426:Alcohol Dehydrogenase; D042843:Glucose 1-Dehydrogenase