title: [Obesity epidemic: origins and consequences].
abstract: Obesity is a chronic disease with serious health consequences. Initial weight gain is related to behavioural and environmental factors acting on a biological (mainly genetic) predisposition. The evolution of the disease is characterized by the development of an inflammatory organ disease that involves the adipocytes and other adipose tissue components. These alterations lead to various clinical complications and to a progressive resistance to diet effects. The treatment of obesity must be adapted to the stage of development of the disease and to the prevalent complications.
authors.affiliation: Inserm, Nutriomique U755 & université Pierre-et-Marie-Curie (Paris 6), service de Nutrition, Hôtel-Dieu, place du Parvis-Notre-Dame, 75004 Paris, France. arnaud.basdevant@htd.aphp.fr
authors.forename: Arnaud
authors.initials: A
authors.lastname: Basdevant
mesh_terms: D000273:Adipose Tissue / Q000002:abnormalities; D004734:Energy Metabolism; D004777:Environment; D006801:Humans; D009765:Obesity / Q000150:complications / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology; D012140:Respiratory Tract Diseases / Q000209:etiology