title: Biological roles of the Lon ATP-dependent protease.
abstract: The Lon ATP-dependent protease plays a major role in protein quality control. An increasing number of regulatory proteins, however, are being identified as Lon substrates, thus indicating that in addition to its housekeeping function, Lon plays an important role in regulating many biological processes in bacteria. This review presents and discusses the involvement of Lon in different aspects of bacterial physiology, including cell differentiation, sporulation, pathogenicity and survival under starvation conditions.
authors.affiliation: Laboratoire de Génétique des Procaryotes, IBMM, Université Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium.
authors.forename: Virginie
authors.initials: V
authors.lastname: Tsilibaris
authors.forename: Geneviève
authors.initials: G
authors.lastname: Maenhaut-Michel
authors.forename: Laurence
authors.initials: L
authors.lastname: Van Melderen
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000502:physiology*; D002454:Cell Differentiation; D002455:Cell Division; D019175:DNA Methylation; D004789:Enzyme Activation; D004926:Escherichia coli / Q000201:enzymology; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D049070:Protease La / Q000502:physiology*; D012486:Salmonella typhimurium / Q000201:enzymology; D015398:Signal Transduction; D013171:Spores, Bacterial / Q000201:enzymology; D013379:Substrate Specificity
chemical_list: D001426:Bacterial Proteins; D049070:Protease La