Role for surgery as adjuvant therapy in optic nerve sheath meningioma.
OBJECTIVE
To describe a role for optic nerve decompression as adjuvant surgical therapy in the management of optic nerve sheath meningioma in patients with severe, progressive visual loss and optic disc edema before or after radiation therapy.


METHODS
Interventional case report.


RESULTS
Two patients with unilateral optic nerve sheath meningioma had progressive visual loss (20/200 and no light perception) and disc edema. The first had previously undergone fractionated stereotactic radiotherapy and the second subsequently was treated with fractionated stereotactic radiotherapy after decompression surgery. After excision of a dural window and biopsy of the tumor from the nerve sheath, visual acuity improved to 20/25 and 20/200, respectively, both coinciding with resolution of disc edema.


CONCLUSIONS
In patients with optic nerve sheath meningioma with severe disc edema and rapid vision loss, surgery may serve an important but restricted, adjuvant role to radiation therapy under special conditions.
Turbin
Roger E
RE
Institute of Ophthalmology and Visual Science, Department of Ophthalmology, UMDNJ - New Jersey Medical School, Newark, New Jersey 07103, USA. turbinre@umdnj.edu
Wladis
Edward J
EJ
Frohman
Larry P
LP
Langer
Paul D
PD
Kennerdell
John S
JS
D000328:Adult; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018317:Nerve Sheath Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D019574:Optic Nerve Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D010211:Papilledema / Q000175:diagnosis; D014786:Vision Disorders / Q000175:diagnosis