title: Sleep and COMT polymorphism in ADHD children: preliminary actigraphic data.
abstract: OBJECTIVE
  To examine whether COMT (catechol-O-methyltransferase) polymorphism modulates aspects of sleep in children diagnosed with attention-deficit/hyperactivity disorder (ADHD).
  
  
  METHODS
  Nightly sleep actigraphic recordings during a double-blind, placebo-controlled, crossover clinical study (1 week of 0.5 mg/kg MPH; 1 week of placebo) were obtained for 34 children, 7.4 to 12 years old, diagnosed with ADHD (DSM-IV). Diagnosis was generated by the Diagnostic Interview Schedule for Children and was confirmed by multidisciplinary consensus.
  
  
  RESULTS
  Children who were Val allele carriers had poorer sleep continuity compared with children with the Met-Met genotype while receiving a placebo and while receiving methylphenidate.
  
  
  CONCLUSIONS
  The findings of the present study support the hypothesis that sleep disturbances in children with ADHD are related to the underlying pathophysiology of the disorder.
authors.affiliation: Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.. Electronic address: reut.gruber@douglas.mcgill.ca.
authors.forename: Reut
authors.initials: R
authors.lastname: Gruber
authors.affiliation: Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.
authors.forename: Natalie
authors.initials: N
authors.lastname: Grizenko
authors.affiliation: Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.
authors.forename: George
authors.initials: G
authors.lastname: Schwartz
authors.affiliation: Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.
authors.forename: Leila
authors.initials: L
authors.lastname: Ben Amor
authors.affiliation: Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Gauthier
authors.affiliation: Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.
authors.forename: Rosherrie
authors.initials: R
authors.lastname: de Guzman
authors.affiliation: Drs. Gruber, Grizenko, and Joober, Mr. Schwartz, Ms. Gauthier, and Ms. de Guzman are with the Douglas Hospital Research Centre and McGill University, Montreal; and Dr. Amor is with the Laval University and Hôpital Hôtel Dieu de Lévis, Quebec City, Canada.
authors.forename: Ridha
authors.initials: R
authors.lastname: Joober
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002648:Child; D018592:Cross-Over Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D011110:Polymorphism, Genetic / Q000235:genetics*; D017286:Polysomnography; D012890:Sleep / Q000502:physiology*
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D002394:Catechol O-Methyltransferase