Evolution of drug resistance in different sublineages of Mycobacterium tuberculosis Beijing genotype.
We compared the population structure and drug resistance patterns of the Mycobacterium tuberculosis strains currently circulating in the Beijing area of China. One hundred thirteen of 123 strains belonged to the Beijing family genotypes defined by spoligotyping. The Beijing genotype strains were further subdivided into old and modern sublineages on the basis of NTF locus analysis. A stronger association with resistance to the more recently introduced antituberculosis drugs has been observed for old versus modern strains of the Beijing genotype, suggesting that its different sublineages may differ in their mechanisms of adaptation to drug selective pressure.
Mokrousov
Igor
I
Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 14 Mira Street, 197101 St. Petersburg, Russia. igormokrousov@yahoo.com
Jiao
Wei Wei
WW
Sun
Gui Zhi
GZ
Liu
Jia Wen
JW
Valcheva
Violeta
V
Li
Mo
M
Narvskaya
Olga
O
Shen
A Dong
AD
D000995:Antitubercular Agents / Q000494:pharmacology*; D005075:Biological Evolution; D002681:China / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D012189:Retrospective Studies; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology*
D000995:Antitubercular Agents