Cell cycle: sustained ERK signalling represses the inhibitors.
The duration of ERK pathway signalling determines the proliferative response of cells. A recent study has shown that cell cycle re-entry requires the downregulation of an anti-proliferative gene cluster following sustained activation of the ERK pathway.
Sharrocks
Andrew D
AD
Faculty of Life Sciences, University of Manchester, UK. a.d.sharrocks@man.ac.uk
D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology; D005786:Gene Expression Regulation; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008957:Models, Genetic
D018797:Cell Cycle Proteins