Pyridostigmine in autonomic failure: can we treat postural hypotension and bladder dysfunction with one drug?
In a 66-year-old man with autonomic failure, pyridostigmine (180 mg/day orally) improved both postural hypotension and underactive detrusor bladder dysfunction. Acetylcholinesterase inhibition may be useful in the management of orthostatic hypotension and bladder dysfunction in autonomic failure patients.
Yamamoto
Tatsuya
T
Dept. of Neurology, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan. tatsuya-yamamoto@mbc.nifty.com
Sakakibara
Ryuji
R
Yamanaka
Yoshitaka
Y
Uchiyama
Tomoyuki
T
Asahina
Masato
M
Liu
Zhi
Z
Ito
Takashi
T
Koyama
Yu
Y
Awa
Yusuke
Y
Yamamoto
Kaori
K
Kinou
Mika
M
Hattori
Takamichi
T
D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011729:Pyridostigmine Bromide / Q000627:therapeutic use*; D001745:Urinary Bladder Diseases / Q000188:drug therapy* / Q000209:etiology
D002800:Cholinesterase Inhibitors; D011729:Pyridostigmine Bromide