Revisiting normal (51)Cr-ethylenediaminetetraacetic acid clearance values in children.
OBJECTIVE
Normal (51)Cr-ethylenediaminetetraacetic acid (EDTA) clearance values as a function of age were published a number of years ago. These values were based on data from children with a normal left to right ratio and a normal appearance on DMSA scintigraphy, despite the presence of an acute renal infection. At that time, the authors were unaware that hyperfiltration is a common phenomenon in patients with acute renal infection and that their normal values could have been significantly overestimated. The present work therefore aimed to re-appraise these normal values.


METHODS
In a first step, in order to verify the previous results, the same type of population was selected, namely patients with present or past urinary tract infection but normal images and a normal left to right ratio on DMSA scintigraphy. In a second step, the selection was based on patients who had had no recent urinary tract infection. In both series, a single blood sample method was used for the evaluation of (51)Cr-EDTA clearance.


RESULTS
In the first group of patients, the results obtained were almost identical to those previously published. In the second group of patients, the results were significantly lower: after 2 years of age, the mean GFR value was 104 ml/min/1.73 m(2) (10th and 90th percentiles 81 and 135 ml/min/1.73 m(2), respectively), compared with 117 ml/min/1.73 m(2) in the first group.


CONCLUSIONS
The data of the second group are probably more representative of the true normal GFR values and can be applied to the entire paediatric population.
Piepsz
A
A
CHU St Pierre, Department of Radioisotopes, Brussels, Belgium. amypiepsz@yahoo.com
Tondeur
M
M
Ham
H
H
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes / Q000737:chemistry; D004492:Edetic Acid / Q000737:chemistry* / Q000493:pharmacokinetics*; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging / Q000503:physiopathology; D008657:Metabolic Clearance Rate; D011866:Radioisotope Renography; D012016:Reference Values; D012189:Retrospective Studies; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014552:Urinary Tract Infections / Q000000981:diagnostic imaging / Q000378:metabolism
D002860:Chromium Radioisotopes; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004492:Edetic Acid