Stilbene derivatives from Pholidota chinensis and their anti-inflammatory activity.
Ethyl acetate extract of Pholidota chinensis L. showed strong NO production inhibitory activity in murine macrophage-like cell line, RAW 264.7, which was activated by a lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). Fractionation of the active extract led to the isolation of two new stilbene derivatives, 2,3'-dihydroxy-5-methoxy-3,4-methylenedioxydihydrostilbene (Pholidotol A) and 2-hydroxy-5-methoxy-3,4,3',4'-dimethylenedioxydihydrostilbene (Pholidotol B) together with six known stilbene derivatives. Pholidotols A both B and inhibited Nitric oxide (NO) production with an IC(50) value at 24.3 and 17.1 microM, respectively.
Wang
Jue
J
Department of Pharmacognosy, College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, China.
Matsuzaki
Keiichi
K
Kitanaka
Susumu
S
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D052117:Benzodioxoles / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D008264:Macrophages / Q000187:drug effects; D008516:Medicine, Chinese Traditional; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D029595:Orchidaceae / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D052117:Benzodioxoles; D013267:Stilbenes; C514003:pholidotol A; C514004:pholidotol B; D009569:Nitric Oxide