Compartmentalized cAMP signalling is important in the regulation of Ca(2+) cycling in the heart.
Co-ordinated myocyte handling of calcium is essential for efficient excitation-contraction coupling in the heart. The calcium cycling activity can be modulated by adrenergic stimulation and subsequent phosphorylation. Important functional consequences of phosphorylation include a greater influx of calcium through the voltage-dependent L-type Ca(2+) channel and a greater release of calcium from SR (sarcoplasmic reticulum) through the ryanodine R2 receptor. Furthermore, a more efficient reuptake through SERCA2 (sarcoplasmic/endoplasmic-reticulum Ca(2+)-ATPase 2) is a result of phosphorylation of its regulatory protein phospholamban. Compartmentalized signalling is important in this signalling cascade, and A-kinase-anchoring proteins play a central role by providing a high level of specificity.
Lygren
B
B
Biotechnology Centre of Oslo, University of Oslo, PO Box 1125 Blindern, N-0317 Oslo, Norway. birgitte.lygren@biotek.uio.no
Taskén
K
K
D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D015398:Signal Transduction
D000242:Cyclic AMP; D002118:Calcium