title: Novel A-ring homodimeric C-3-carbamate analogues of 1alpha,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation.
abstract: The synthesis of a new class of vitamin D3 analogues in which two units of 1alpha,25-dihydroxyvitamin D3 are linked at the C-3 position by a dicarbamate functionality of variable length is described. The analogues demonstrated no affinity for the vitamin D receptor and possessed no antiproliferative or transactivating properties.
authors.affiliation: Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006-Oviedo (Asturias), Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Oves
authors.forename: Susana
authors.initials: S
authors.lastname: Fernández
authors.forename: Lieve
authors.initials: L
authors.lastname: Verlinden
authors.forename: Roger
authors.initials: R
authors.lastname: Bouillon
authors.forename: Annemieke
authors.initials: A
authors.lastname: Verstuyf
authors.forename: Miguel
authors.initials: M
authors.lastname: Ferrero
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor
mesh_terms: D000818:Animals; D002219:Carbamates / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D019281:Dimerization; D006801:Humans; D015394:Molecular Structure; D018167:Receptors, Calcitriol / Q000378:metabolism; D013329:Structure-Activity Relationship; D013552:Swine; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002219:Carbamates; D018167:Receptors, Calcitriol; C118756:dihydroxy-vitamin D3; D014807:Vitamin D