Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety.
A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.
Karthikeyan
Mari Sithambaram
MS
Department of Chemistry, Mangalore University, Mangalagangothri 574199, India. karthims02@rediffmail.com
Prasad
Dasappa Jagadeesh
DJ
Poojary
Boja
B
Subrahmanya Bhat
K
K
Holla
Bantwal Shivarama
BS
Kumari
Nalilu Suchetha
NS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D002713:Chlorine / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005461:Fluorine / Q000737:chemistry*; D006095:Gram-Positive Cocci / Q000187:drug effects; D008352:Mannich Bases / Q000138:chemical synthesis / Q000737:chemistry; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D008352:Mannich Bases; D012545:Schiff Bases; D005461:Fluorine; D002713:Chlorine