title: Quantitative assessment of WT1 expression in diagnosis of childhood acute leukemia.
abstract: The purpose of this study was to investigate WT1 expression levels in childhood acute leukemia. Bone marrow from 14 children with acute leukemia at diagnosis and from 7 children with solid tumors without bone marrow involvement (control group) was studied. Five of the 14 patients (35.7%), expressed high levels of WT1. Four of the five WT1 positive patients with additional adverse prognostic factors, have succumbed to their disease. The results of this study are in accordance with the fact that high levels of WT1 expression have been reported in patients with an unfavorable outcome.
authors.forename: A
authors.initials: A
authors.lastname: Spanaki
authors.forename: E
authors.initials: E
authors.lastname: Linardakis
authors.forename: C
authors.initials: C
authors.lastname: Perdikogianni
authors.forename: E
authors.initials: E
authors.lastname: Stiakaki
authors.forename: A
authors.initials: A
authors.lastname: Morotti
authors.forename: D
authors.initials: D
authors.lastname: Cilloni
authors.forename: M
authors.initials: M
authors.lastname: Kalmanti
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D025721:WT1 Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D025721:WT1 Proteins