title: Multidrug-resistant genes are associated with an 86-kb island in Acinetobacter baumannii.
abstract: A strain of multidrug-resistant Acinetobacter baumannii that caused a 26% mortality rate in a French epidemic was characterized and compared with an antibiotic-susceptible strain of A. baumannii. The multiresistant strain carries many of its antibiotic-resistance genes on an 86-kb region, whereas the susceptible strain lacks these genes in a homologous region. Characterization of this multidrug-resistant A. baumannii strain highlights the limited options for current therapy and raises concerns for future treatment options in an era in which few novel antibiotics are being developed.
authors.affiliation: Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA. marilynr@u.washington.edu
authors.forename: Marilyn C
authors.initials: MC
authors.lastname: Roberts
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics; D019216:Metals, Heavy / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D019216:Metals, Heavy