A tale of two estrogen receptors (ERs): how differential ER-estrogen responsive element interactions contribute to subtype-specific transcriptional responses.
The interaction of ERalpha and ERbeta with ERE constitutes the initial step in the canonical nuclear E2 signaling in which E2-ERbeta is a weaker transactivator than E2-ERalpha. This perspective summarizes recent findings to discuss potential mechanisms that contribute to ER subtype-specific transcriptional responses.
Huang
Jing
J
Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY, USA.
Li
Xiaodong
X
Qiao
Tao
T
Bambara
Robert A
RA
Hilf
Russell
R
Muyan
Mesut
M