Frontal lobe metabolic decreases with sleep deprivation not totally reversed by recovery sleep.
We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.
Wu
Joseph C
JC
UC Irvine Department of Psychiatry and Human Behavior, Irvine, CA, USA. jcwu@uci.edu
Gillin
J Christian
JC
Buchsbaum
Monte S
MS
Chen
Phillip
P
Keator
David B
DB
Khosla Wu
Neetika
N
Darnall
Lynn A
LA
Fallon
James H
JH
Bunney
William E
WE
D000328:Adult; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D020127:Recovery of Function / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D013788:Thalamus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology