title: Involvement of the RNAse L gene in prostate cancer.
abstract: Prostate cancer is one of the most common cancers among men and has long been recognized to occur in familial clusters. Identification of genetic susceptibility loci for prostate cancer has however been extremely difficult, and only in 1996 was the first prostate cancer susceptibility locus HPC1 mapped to chromosome 1q24-25. Since, several additional putative loci have been identified by genetic linkage analysis on chromosome 1, 17, 20 and X (reviewed in). For three of these loci, family-based studies have identified three genes associated with inherited prostate cancer: the 3' processing endoribonuclease ELAC2/HPC2 gene, the macrophage scavenger receptor 1 gene (MSR1), and the endoribonuclease RNase L gene (RNAse L/HPC1). Here we will focus our review on the RNAse L gene and its involvement in prostate cancer and other diseases.
authors.affiliation: Laboratoire de Biologie et Physiologie Intégrée (CNRS/GDRE-ITI), Université du Luxembourg.
authors.forename: Nelly
authors.initials: N
authors.lastname: Kieffer
authors.forename: Martine
authors.initials: M
authors.lastname: Schmitz
authors.forename: René
authors.initials: R
authors.lastname: Scheiden
authors.forename: Michel
authors.initials: M
authors.lastname: Nathan
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Faber
mesh_terms: D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004722:Endoribonucleases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000235:genetics*
chemical_list: D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease