title: Feedback dynamics and cell function: Why systems biology is called Systems Biology.
abstract: A new paradigm, like Systems Biology, should challenge the way research has been conducted previously. This Opinion article aims to present Systems Biology, not as the application of engineering principles to biology but as a merger of systems- and control theory with molecular- and cell biology. In our view, the central dogma of Systems Biology is that it is system dynamics that gives rise to the functioning and function of cells. The concepts of feedback regulation and control of pathways and the coordination of cell function are emphasized as an important area of Systems Biology research. The hurdles and risks for this area are discussed from the perspective of dynamic pathway modelling. Most of all, the aim of this article is to promote mathematical modelling and simulation as a part of molecular- and cell biology. Systems Biology is a success if it is widely accepted that there is nothing more practical than a good theory.
authors.affiliation: Department of Computer Science, University of Rostock, Albert Einstein Str. 21, 18059 Rostock, Mecklenburg-Vorpommern, Germany. olaf.wolkenhauer@uni-rostock.de
authors.forename: Olaf
authors.initials: O
authors.lastname: Wolkenhauer
authors.forename: Mihajlo
authors.initials: M
authors.lastname: Mesarovic
mesh_terms: D019295:Computational Biology; D003198:Computer Simulation; D005246:Feedback; D008954:Models, Biological; D049490:Systems Biology