title: Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease.
abstract: To investigate the effect of single nucleotide polymorphisms (SNPs) of the upstream stimulatory factor (USF) 1 and 2 genes on the onset of Alzheimer's disease (AD), a case-control study was performed. The SNPs were genotyped by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 236 AD patients and 120 age-matched controls of Japanese descent. We observed no significant association between the three SNPs of the USF 1 gene and AD in our Japanese participants. In addition, the SNPs studied did not affect plasma cholesterol levels in our AD cases. For the USF 2 gene, the two SNPs did not show significant association with onset of AD. Our study suggests that the three SNPs of the USF 1 gene and two SNPs of the USF 2 gene presented here are not associated with onset of AD.
authors.affiliation: Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan. nobuto.shibata@nifty.ne.jp
authors.forename: Nobuto
authors.initials: N
authors.lastname: Shibata
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohnuma
authors.forename: Shinji
authors.initials: S
authors.lastname: Higashi
authors.forename: Maiko
authors.initials: M
authors.lastname: Higashi
authors.forename: Chie
authors.initials: C
authors.lastname: Usui
authors.forename: Taku
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Tomoko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Kawashima
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Kitajima
authors.forename: Akira
authors.initials: A
authors.lastname: Ueki
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Nagao
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D018709:Statistics, Nonparametric; D051720:Upstream Stimulatory Factors / Q000235:genetics*
chemical_list: C497181:USF1 protein, human; C497184:USF2 protein, human; D051720:Upstream Stimulatory Factors