Quantitative aspects of the degradation of mitomycin C in alkaline solution.
The alkaline hydrolysis of mitomycin C has been studied over a wide range of pH/H_(7-15). A stability-indicating high-performance liquid chromatographic (HPLC) method was used to separate the degradation products from the parent drug. The quantitative effects of temperature and buffers on the degradation of mitomycin C in alkali have been determined. A profile of log k(obs) against pH/H_ was constructed after corrections had been made for buffer effects and after extrapolation to 25 degrees C by application of the Arrhenius equation.
Beijnen
J H
JH
Department of Analytical Pharmacy, Subfaculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511 GH Utrecht, The Netherlands.
den Hartigh
J
J
Underberg
W J
WJ