title: Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system.
abstract: We describe a compact diffuse optical tomography system specifically designed for breast imaging. The system consists of 64 silicon photodiode detectors, 64 excitation points, and 10 diode lasers in the near-infrared region, allowing multispectral, three-dimensional optical imaging of breast tissue. We also detail the system performance and optimization through a calibration procedure. The system is evaluated using tissue-like phantom experiments and an in vivo clinic experiment. Quantitative two-dimensional (2D) and three-dimensional (3D) images of absorption and reduced scattering coefficients are obtained from these experiments. The ten-wavelength spectra of the extracted reduced scattering coefficient enable quantitative morphological images to be reconstructed with this system. From the in vivo clinic experiment, functional images including deoxyhemoglobin, oxyhemoglobin, and water concentration are recovered and tumors are detected with correct size and position compared with the mammography.
authors.affiliation: Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611-6131, USA.
authors.forename: Changqing
authors.initials: C
authors.lastname: Li
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Zhao
authors.forename: Bonnie
authors.initials: B
authors.lastname: Anderson
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000465:Algorithms; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D002138:Calibration; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods*; D008327:Mammography / Q000295:instrumentation / Q000379:methods; D055095:Optics and Photonics; D010108:Oxyhemoglobins / Q000737:chemistry; D019047:Phantoms, Imaging; D012825:Silicon; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D014867:Water; C100003:deoxyhemoglobin; D012825:Silicon