Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patients.
A relationship between response to lithium prophylaxis and T-50C polymorphism of glycogen synthase kinase-3beta (GSK-3beta) gene was investigated in 89 bipolar patients (41 male and 48 female) who have been taking lithium for at least 5 years. The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be related to the degree of prophylactic lithium response.
Szczepankiewicz
Aleksandra
A
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poland. alszczep@amp.edu.pl
Rybakowski
Janusz K
JK
Suwalska
Aleksandra
A
Skibinska
Maria
M
Leszczynska-Rodziewicz
Anna
A
Dmitrzak-Weglarz
Monika
M
Czerski
Piotr M
PM
Hauser
Joanna
J
D000328:Adult; D000483:Alleles; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006720:Homozygote; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D055502:Secondary Prevention; D013223:Statistics as Topic; D016896:Treatment Outcome
D018692:Antimanic Agents; D016651:Lithium Carbonate; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3