AA amyloidosis in psoriatic arthritis.
BACKGROUND
Amyloidosis is an extremely rare complication of psoriatic arthritis (PsA) and is associated with a poor prognosis. We report a case of amyloidosis secondary to severe PsA in a young patient and the course of his disease over a 13-year period of aggressive immunosuppression.


METHODS
Diagnosis of renal amyloidosis was made on biopsy: multi-agent immunosuppressive therapy was continued with stabilisation of renal function.


RESULTS
Marked deterioration in renal function subsequently occurred following a reduction in cyclosporin A (CyA) dose and repeat biopsy confirmed worsening amyloidosis.


CONCLUSIONS
This case report emphasises the need for aggressive control of the inflammatory response in secondary amyloidosis.
Ryan
J G
JG
Dept of Rheumatology, Beaumont Hospital, Dublin. johngryan@gmail.com
Dorman
A M
AM
O'Connell
P G
PG
D000328:Adult; D000686:Amyloidosis / Q000188:drug therapy / Q000209:etiology*; D015535:Arthritis, Psoriatic / Q000150:complications*; D009202:Cardiomyopathies / Q000209:etiology; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology
D007166:Immunosuppressive Agents; D016572:Cyclosporine