title: Churg-Strauss syndrome and congenital factor Leiden thrombophilia as nontypical causes of intracardiac thrombosis.
abstract: We present and discuss the case of a 26-year-old man suffering from Churg-Strauss syndrome (CSS). In our patient the disease severely affected both the heart and the lungs. Left ventricular dysfunction and intracardiac thrombosis, probably secondary to the cardiotoxic effect of eosinophils, were revealed by echocardiography. The risk of thrombosis was additionally increased by the coexistence of the factor V Leiden gene mutation. An opportunely established diagnosis allowed institution of an appropriate pharmacotherapy and subsequently to obtain a significant abatement of the clinical symptoms as well as the laboratory manifestations of the disease.
authors.affiliation: Department of Cardiology, Silesian University, Faculty of Medicine, Ziołowa Street 45/47, 40-635 Katowice, Poland. kmizia@op.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Mizia-Stec
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Gasior
authors.forename: Jan
authors.initials: J
authors.lastname: Duława
authors.forename: Mirosława
authors.initials: M
authors.lastname: Janowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Pysz
authors.forename: Magdalena
authors.initials: M
authors.lastname: Mizia
mesh_terms: D000328:Adult; D015267:Churg-Strauss Syndrome / Q000150:complications*; D018618:Echocardiography, Doppler, Color; D005165:Factor V / Q000235:genetics*; D006331:Heart Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D009154:Mutation; D013256:Steroids / Q000627:therapeutic use; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics; D013927:Thrombosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology
chemical_list: D013256:Steroids; C095381:factor V Leiden; D005165:Factor V