Analysis of tablets containing acetylsalicylic acid and phenylephrine by high-performance liquid chromatography.
A high-performance liquid chromatographic method permitted the quantitation of acetylsalicylic acid, phenylephrine, caffeine and phenacetin in tablets, and of the main impurities, salicylic acid and mono- and diacetyl derivatives of phenylephrine. A C8 reversed-phase column was used with a mobile phase containing methanol-1 M phosphoric acid-water 34:5:61 v/v/v.
Wouters
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I
Katholieke Universiteit Leuven, Instituut voor Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie, Van Evenstraat 4, 3000 Leuven, Belgium.
Roets
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E
Hoogmartens
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J