Biphasic synovial sarcoma of the abdominal wall.
Synovial sarcoma arising in the abdominal wall is a rare tumor. We report a case of a 38-year-old man who complained of abdominal pain. Physical examination revealed a firm mobile mass, 25 cm in diameter, in the left lower abdominal wall. The tumor was first thought to be a sarcoma arising from the omentum or mesentery. During surgery, a large tumor was found attached to the inner surface of the abdominal wall and compressing the gastrointestinal tract. On microscopic examination the tumor corresponded to a biphasic synovial sarcoma immunoreactive for cytokeratins (AE1/AE3, 7 and 19), epithelial membrane antigen and carcinoembryonic antigen in the epithelial tumor cells, for E-cadherin especially in their glandular structure, vimentin, CD99, and CD56 in the spindle cell component and for bcl-2 protein. The tumor recurred at the same site, and clinical course progressed to death 3 months after the initial diagnosis.
Vera
Jesús
J
Department of Pathology, Hospital General San Jorge, Avenida Martinez de Velasco, 36, 22071, Huesca, Spain. jjvera@salud.aragon.es
García
María-Dolores
MD
Marigil
Miguel
M
Abascal
Manuel
M
Lopez
Jose-Ignacio
JI
Ligorred
Luis
L
D000071443:12E7 Antigen; D000008:Abdominal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D034861:Abdominal Wall / Q000473:pathology* / Q000601:surgery; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D015820:Cadherins / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002296:Carcinosarcoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D009364:Neoplasm Recurrence, Local; D013584:Sarcoma, Synovial / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000032:analysis
D000071443:12E7 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D019002:CD56 Antigen; C061828:CD99 protein, human; D015820:Cadherins; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D014746:Vimentin; D007633:Keratins