Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome.
We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characterization of a Brazilian DENV-3 strain since its introduction into the country in 2001. DENV-3 was responsible for the most severe dengue epidemic in the state, based on the highest number of reported cases and on the severity of clinical manifestations and deaths reported.
Miagostovich
Marize Pereira
MP
Departamento de Virologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, 21040-900, Brasil. marizepm@ioc.fiocruz.br
dos Santos
Flávia Barreto
FB
Fumian
Túlio Machado
TM
Guimarães
Flávia Ramos
FR
da Costa
Eliane Veiga
EV
Tavares
Fernando Neto
FN
Coelho
Janice Oliveira
JO
Nogueira
Rita Maria Ribeiro
RM
D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D001938:Brazil; D003716:Dengue Virus / Q000235:genetics* / Q000302:isolation & purification; D017809:Fatal Outcome; D005260:Female; D005838:Genotype; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D019595:Severe Dengue / Q000821:virology*
D012367:RNA, Viral