Finding the groove.
Envisioning how T cells might recognize antigen presented by major histocompatibility complex molecules proved to be a formidable challenge. Pamela Bjorkman describes her journey to provide structural insights into how such recognition is achieved.
Bjorkman
Pamela J
PJ
Howard Hughes Medical Institute and Division of Biology 114-96, California Institute of Technology, Pasadena, California 91125, USA. bjorkman@caltech.edu
D000486:Allergy and Immunology / Q000266:history; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D049673:History, 20th Century; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*