title: Insights into the regulation of the ryanodine receptor: differential effects of Mg2+ and Ca2+ on ATP binding.
abstract: Calcium ions are frequently used second messengers in most living organisms. Members of the family of ryanodine sensitive calcium channels (ryanodine receptors, RyRs) are responsible for many important Ca(2+) signaling events in both excitable and nonexcitable cells. The biological activity of these membrane proteins is modulated and regulated by a great variety of different cellular and extracellular effectors, proteins, and small molecules. However, very little is still understood about how the modulators work on a molecular level. The very large size of more than 2 million Da per functional tetrameric RyR unit and its membrane association have made more detailed biochemical and structural analysis extremely challenging.
authors.affiliation: Department of Biological Sciences, Southern Methodist University, 6501 Airline Road, Dallas, Texas 75275, USA.
authors.forename: José M
authors.initials: JM
authors.lastname: Dias
authors.forename: Csaba
authors.initials: C
authors.lastname: Szegedi
authors.forename: Istvan
authors.initials: I
authors.lastname: Jóna
authors.forename: Pia D
authors.initials: PD
authors.lastname: Vogel
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000737:chemistry / Q000378:metabolism*; D002413:Cations, Divalent / Q000737:chemistry / Q000378:metabolism; D008274:Magnesium / Q000737:chemistry / Q000378:metabolism*; D011817:Rabbits; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002413:Cations, Divalent; D019837:Ryanodine Receptor Calcium Release Channel; C026652:3'-O-(1-oxyl-2,2,5,5-tetramethyl-3-carbonyl pyrrolidine)-adenosine 5'-triphosphate; D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium