Two new sesquiterpene lactones from the leaves of Laurus nobilis.
As a part of our ongoing interest in new bioactive compounds from natural sources, we studied Laurus nobilis (Lauraceae). This plant is widespread in the Mediterranean area and is used for medicinal and economic purposes. Chromatographic separations on active extracts led to the isolation of two new sesquiterpene lactones, 5a,9-dimethyl-3-methylene-3,3a,4,5,5a,6,7,8-octahydro-1-oxacyclopenta[c]azulen-2-one (1) and 3beta-chlorodehydrocostuslactone (2). The structures of the new compounds were identified by 1D and 2D NMR experiments, as well as high resolution mass spectrometry. The cytotoxic activity was also evaluated against three different tumor cell lines of human origin.
Dall'Acqua
Stefano
S
Dipartimento di Scienze Farmaceutiche, Università di Padova, Viale S. Ignacio 13, 09124 Cagliari, Italy.
Viola
Giampietro
G
Giorgetti
Michela
M
Loi
Maria Cecilia
MC
Innocenti
Gabbriella
G
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005060:Europe; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D027442:Laurus / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
C513994:3-chlorodehydrocostuslactone; C513993:5a,9-dimethyl-3-methylene-3,3a,4,5,5a,6,7,8-octahydro-1-oxacyclopenta(c)azulen-2-one; D007783:Lactones; D012717:Sesquiterpenes