[Natural killer-like T-cell lymphoma/leukemia--a case report and literature review].
OBJECTIVE
To identify the clinical and pathological features of natural killer-like T-cell lymphoma/leukemia.


METHODS
The characteristics of natural killer-like T-cell lymphoma/leukemia was discussed with report a new case and review of literatures.


RESULTS
A 16-year-old girl was referred to our hospital because of fever and disseminated cutaneous herpes and ulcer. Atypical lymphoid cells surrounded the dermal vessels with a CD3(+), CD8(+), CD4(-), CD5(-), CD10(-), CD19(-), CD57(-), CD56(+), perforin(+), granzyme B(+) immunophenotype and rearranged T-cell receptor-gamma gene implicated natural killer-like T cell origin. She was treated with prednisone and for several months. Then the patient developed progressive spleen enlargement with overt leukemia, which led to her eventual death.


CONCLUSIONS
Natural killer-like T-cell lymphoma/leukemia is a rare disease with distinctive clinical, histopathologic, and immuno phenotypic characteristics. Current treatment modalities are ineffective for most of the patients.
Zhang
Feng-kui
FK
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.
Wang
Hui-jun
HJ
Wu
Yu-hong
YH
Dong
Shu-xu
SX
Li
Hong-qiang
HQ
Yang
Dong-lin
DL
Chen
Hui-shu
HS
Chu
Yu-lin
YL
D000293:Adolescent; D019002:CD56 Antigen / Q000276:immunology; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology*; D015458:Leukemia, T-Cell / Q000276:immunology / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology*
D019002:CD56 Antigen