Autophagy, mitochondrial quality control, and oncogenesis.
Cancer is a disease associated with aging. More than 80% of human cancers are diagnosed in people aged 55 years or older. Autophagy has recently been demonstrated to be a novel mechanism of tumor suppression. Interestingly, autophagy also plays an important role in the control of aging. Here we summarize the genetic studies of autophagy in tumorigenesis and aging, and propose that autophagy may suppress tumor development and prevent aging through a common mechanism involving mitochondrial surveillance.
Jin
Shengkan
S
Pharmacology Department and the Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA. jinsh@umdnj.edu
D000818:Animals; D001343:Autophagy; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D004272:DNA, Mitochondrial / Q000235:genetics / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism
D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species