Molecular mobility of interlocked structures exploiting new functions of advanced biomaterials.
Cyclic compounds can rotate and/or slide along a polymeric chain in a polyrotaxane structure, and the mobility of the ligands linked by the cyclic compounds is closely related to enhancing the multivalent interaction with binding sites on the receptor proteins. This concept is being exploited in more practical applications in the biomedical and pharmaceutical fields, such as a non-viral gene carriers.
Yui
Nobuhiko
N
The School of Materials Science and the 21st Century COE Program, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan. yui@jaist.ac.jp
Ooya
Tooru
T
D001672:Biocompatible Materials / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D007700:Kinetics; D008968:Molecular Conformation; D043862:Rotaxanes / Q000737:chemistry*; D013816:Thermodynamics
D001672:Biocompatible Materials; D003505:Cyclodextrins; D043862:Rotaxanes