title: Cell stress response in skeletal muscle myofibers.
abstract: Cells respond to conditions that impair homeostasis through ex novo synthesis of stress proteins, which differ in subcellular localization and biological function and whose differential expression depends on the type of the stressing stimulus and on the involvement of the specific stress-response signaling cascade. The biological significance of such an event is the increased resistance against further perturbations of cell homeostasis, and thus, enhanced survival. We will review briefly the available evidence concerning stress response of skeletal muscle cells, including recent results indicating the involvement of endoplasmic reticulum stress response and proteins in skeletal muscle cell differentiation and in progression of muscle diseases.
authors.affiliation: Department of Biomedical Sciences, University of Padova, Padova, Italy. elena.tarricone@unipd.it
authors.forename: Elena
authors.initials: E
authors.lastname: Tarricone
authors.forename: Anna
authors.initials: A
authors.lastname: Ghirardello
authors.forename: Sandra
authors.initials: S
authors.lastname: Zampieri
authors.forename: Rampudda Maria
authors.initials: RM
authors.lastname: Elisa
authors.forename: Andrea
authors.initials: A
authors.lastname: Doria
authors.forename: Luisa
authors.initials: L
authors.lastname: Gorza
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006706:Homeostasis; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism* / Q000473:pathology*; D009210:Myofibrils / Q000378:metabolism* / Q000473:pathology*