title: Determination of morphine in human plasma by radioimmunoassay utilising a preliminary liquid-solid extraction.
abstract: Numerous assays are available for the pharmacokinetic study of morphine. Two of these methods are compared with a new assay procedure, which involves a solid-phase extraction to clean up human plasma before radioimmunoassay allowing the determination of morphine levels to a sensitivity of 1 mugl(-1). Data are presented to show the importance of correct method choice if clinical studies are to be used in pharmacokinetic interpretations.
authors.affiliation: Bioanalytical Department Napp Research Centre Ltd, Cambridge Science Park, Milion Road, Cambridge, UK.
authors.forename: K
authors.initials: K
authors.lastname: Quinn
authors.forename: D B
authors.initials: DB
authors.lastname: Galloway
authors.forename: S T
authors.initials: ST
authors.lastname: Leslie
authors.forename: C
authors.initials: C
authors.lastname: Ness
authors.forename: S
authors.initials: S
authors.lastname: Robertson
authors.forename: A
authors.initials: A
authors.lastname: Shill