[Preparation of ondansetron hydrochloride sustained-release tablet evaluation of its and drug release behavior in vitro].
For the purpose of preparing the ondansetron hydrochloride sustained-release tablets and studying the influencing factors, we prepared the ondansetron hydrochloride sustained-release tablets, using hydroxypropylmethylcellose (HPMC) as the matrix material. Then we investigated the effects of the viscosity and amount of HPMC,the sort of fillers, the preparation methods, the alcohol content in adhesives, and the pH of the dissolving solution on the release of ondansetron hydrochloride from sustained-release tablets. On the basis of pharmaceutical preformulation studies,the best formulation and preparation methods were screened out according to orthogonal experiment design method. The release behavior of the tablets followed the Higuchi equation. The viscosity of HPMC,the sort of fillers and the rotation speed had no significant effects on the release of ondansetron hydrochloride sustained-release tablets,while the preparation methods, the alcohol content in adhesives and the pH of the dissolving solution influcenced the release of ondansetron hydrochloride sustained-release tablets significantly. Ondansetron hydrochloride sustained-release tablets had good drug relase behavior for in 12 h in vitro.
Zhang
Yuhong
Y
College of Pharmacy, Shandong University, Ji'nan 250012, China. zhy6789@126.com
Huang
Guihua
G
Yu
Yanling
Y
Han
Jingbin
J
Yu
Ping
P
D003692:Delayed-Action Preparations; D007785:Lactose / Q000031:analogs & derivatives / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D008956:Models, Chemical; D017294:Ondansetron / Q000008:administration & dosage* / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013607:Tablets; D014783:Viscosity
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D013607:Tablets; C509290:hydroxypropylmethylcellulose-lactose matrix; D017294:Ondansetron; D008747:Methylcellulose; D007785:Lactose