title: [Haplotypes of DXS10011 and DXS8377 in Guangdong Han individuals].
abstract: OBJECTIVE
  To investigate genetic polymorphism of two X chromosome specific STR: DXS10011 and DXS8377 in male samples from Guangdong Han population.
  
  
  METHODS
  The DNA samples were amplified by PCR and analyzed by polyacrylamide gel electrophoresis followed by silver staining.
  
  
  RESULTS
  Among 113 samples, 20 alleles were found for DXS1011 and 12 alleles for DXS8377. Also, 72 DXS10011-DXS8377 haplotypes were shown. The most common haplotypes only occurred three times. When only female children were tested in motherless case, the exclusion probability of paternity was 0.9588 for DXS10011-DXS8377 haplotypes. Investigations in 83 family trios with female children and 29 pedigrees with two children suggested a co-dominant X-linked inheritance; mutations were not found.
  
  
  CONCLUSIONS
  Our data indicate that DXS10011 and DXS8377 are highly informative X chromosome markers for complicated kinship analysis.
authors.affiliation: Department of Forensic Serology, Zhongshan-Medical College, Sun Yat-sen University, Guangzhou 510089, China. dejian6182@sina.com
authors.forename: De-Jian
authors.initials: DJ
authors.lastname: Lu
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Chen
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Qiu-Ling
authors.initials: QL
authors.lastname: Liu
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Lu
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D041321:Chromosomes, Human, X / Q000235:genetics*; D004247:DNA / Q000097:blood / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D044707:Forensic Sciences; D005787:Gene Frequency; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D008297:Male; D010334:Paternity; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences
chemical_list: D004247:DNA