title: The natural course of cytomegalovirus infection and disease in renal transplant recipients.
abstract: A series of prospective studies of a large cohort population of renal transplant recipients who did not receive cytomegalovirus (CMV) prophylaxis or preemptive therapy examined the effects of CMV infection and disease on renal allograft rejection, long-term recipient and graft survival, and new-onset diabetes mellitus. CMV infection and disease were found to be independent risk factors for allograft rejection and new-onset diabetes mellitus within 100 days posttransplantation, and for recipient mortality and uncensored graft loss beyond 100 days posttransplantation. Additional studies are needed to determine whether CMV prophylaxis or preemptive therapy may be of benefit in preventing these complications.
authors.affiliation: Department of Medicine, Rikshospitalet University Hospital, Rikshospitalet, Oslo, Norway. anders.hartmann@rikshospitalet.no
authors.forename: Anders
authors.initials: A
authors.lastname: Hartmann
authors.forename: Solbjørg
authors.initials: S
authors.lastname: Sagedal
authors.forename: Jøran
authors.initials: J
authors.lastname: Hjelmesaeth
mesh_terms: D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000503:physiopathology; D048909:Diabetes Complications / Q000453:epidemiology / Q000821:virology; D006084:Graft Rejection / Q000453:epidemiology / Q000821:virology; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000503:physiopathology / Q000821:virology*; D012307:Risk Factors