Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides.
A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 microM) and demonstrated modest adhesion inhibition to cell surface CSA.
Adams
Yvonne
Y
Hygiene-Institut, Abteilung Parasigologie, Universität Heidelberg, Germany.
Freeman
Craig
C
Schwartz-Albiez
Reinhard
R
Ferro
Vito
V
Parish
Christopher R
CR
Andrews
Katherine T
KT
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002809:Chondroitin Sulfates / Q000494:pharmacology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006497:Heparan Sulfate / Q000494:pharmacology*; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D009844:Oligosaccharides / Q000378:metabolism / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000166:cytology / Q000187:drug effects*; D013431:Sulfates / Q000737:chemistry
D000962:Antimalarials; D002809:Chondroitin Sulfates; D006497:Heparan Sulfate; D009844:Oligosaccharides; D013431:Sulfates