Moxifloxacin lethality against Mycobacterium tuberculosis in the presence and absence of chloramphenicol.
The C-8-methoxy fluoroquinolone moxifloxacin was more lethal against chloramphenicol-treated Mycobacterium tuberculosis than Bay y3114, a C-8-H cognate of moxifloxacin, and two C-8-methoxy fluoroquinolones, gatifloxacin and BMS-433368, which have different C-7 substituents. Thus, an optimal combination of C-7 and C-8 substituents is likely to be important for killing nongrowing M. tuberculosis.
Malik
Muhammad
M
Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA.
Drlica
Karl
K
D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D001372:Aza Compounds / Q000737:chemistry / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024841:Fluoroquinolones / Q000737:chemistry / Q000494:pharmacology; D000077734:Gatifloxacin; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D000077266:Moxifloxacin; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*
D000995:Antitubercular Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011500:Protein Synthesis Inhibitors; D011804:Quinolines; D002701:Chloramphenicol; D000077734:Gatifloxacin; D000077266:Moxifloxacin