title: Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier.
abstract: In providing the cell with ATP generated by oxidative phosphorylation, the mitochondrial ADP/ATP carrier plays a central role in aerobic eukaryotic cells. Combining biochemical, genetic, and structural approaches contributes to understanding the molecular mechanism of this essential transport system, the dysfunction of which is implicated in neuromuscular diseases.
authors.affiliation: Département de Réponse et Dynamique Cellulaires, CEA-Grenoble, Laboratoire de Biochimie et Biophysique des Systèmes Intégrés, UMR 5092 CEA-CNRS-Université Joseph Fourier, Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Dahout-Gonzalez
authors.forename: H
authors.initials: H
authors.lastname: Nury
authors.forename: V
authors.initials: V
authors.lastname: Trézéguet
authors.forename: G J-M
authors.initials: GJ
authors.lastname: Lauquin
authors.forename: E
authors.initials: E
authors.lastname: Pebay-Peyroula
authors.forename: G
authors.initials: G
authors.lastname: Brandolin
mesh_terms: D000818:Animals; D001278:Atractyloside / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D019069:Cell Respiration / Q000502:physiology; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008931:Mitochondria, Muscle / Q000502:physiology; D000226:Mitochondrial ADP, ATP Translocases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009468:Neuromuscular Diseases / Q000503:physiopathology*
chemical_list: D001278:Atractyloside; D000226:Mitochondrial ADP, ATP Translocases; C003853:carboxyatractyloside