Pulmonary consequences of transfusion: TRALI and TACO.
Transfusion-related acute lung injury and transfusion-associated circulatory overload are important, life-threatening complications of transfusion. Each adversely impact hospital length of stay and cost of healthcare. TRALI is clinically indistinguishable from the adult respiratory distress syndrome but it has a more favorable prognosis. Approximately 10% of TRALI patients die from this complication. The at-risk patient for TRALI has not been identified. The most commonly cited incidence is 1:5000 plasma-containing blood component transfusions. Although several pathways may lead to TRALI, passive transfusion of leukocyte antibodies is currently the most important association. TACO occurs in 1-8% of patients undergoing hip or knee arthroplasty. It is precipitated by positive fluid balance and high transfusion flow rates. TACO is characterized by respiratory distress and acute pulmonary edema.
Popovsky
Mark A
MA
Haemonetics Corporation Address, 400 Wood Road, Braintree, MA 02184, USA. mpopovsky@haemonetics.com
D000707:Anaphylaxis / Q000209:etiology; D003937:Diagnosis, Differential; D006801:Humans; D011654:Pulmonary Edema / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D065227:Transfusion Reaction