Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.
Disulfiram, a drug used to treat alcoholism, has recently been indicated to play a primary as well as an adjuvant role in the treatment of many cancers and in the reversal of fungal drug-resistance. This review discusses the molecular mechanism of action of disulfiram and its potential use in the treatment of human cancers and fungal infections.
Sauna
Zuben E
ZE
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892-4256, USA.
Shukla
Suneet
S
Ambudkar
Suresh V
SV
D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D004221:Disulfiram / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D009181:Mycoses / Q000188:drug therapy*; D009369:Neoplasms / Q000188:drug therapy*
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D004221:Disulfiram