title: Correlation of sonographic severity with biochemical markers of synovium and cartilage in knee osteoarthritis patients.
abstract: OBJECTIVE
  Ultrasonography can be used to detect soft tissue abnormalities within the joints that cannot be assessed using conventional X-rays. This study investigated the relationship between soft tissue and/or bony abnormalities on ultrasonography and the biochemical markers of the synovium and cartilage in the knee of osteoarthritis (OA) patients.
  
  
  METHODS
  The knees from 51 OA patients who fulfilled the ACR criteria were enrolled in this study. Knee ultrasonography was performed in the affected knee joints using a 12 MHz linear probe to assess the presence of effusion, synovial proliferation, capsular distention, the length of osteophytes and the cartilage thickness. At the same time, the serum hyaluronic acid (HA) and the cartilage oligomeric protein (COMP) levels were measured by ELISA, and RIA was used to determine the serum osteocalcin levels.
  
  
  RESULTS
  The patients with a longer medial osteophyte showed higher serum HA and COMP levels than those with a shorter one. The serum HA levels were significantly higher in those patients with a larger amount of effusion and/or synovial proliferation, which indicated inflammatory changes, than in those without. In addition, the severity of the capsular distention also correlated well with the serum HA and COMP levels. However, the length of the lateral osteophytes and the thickness of the femoral cartilage showed no correlation with the serum HA or COMP levels. In addition, the serum osteocalcin levels did not show any association with the above ultrasonographic parameters.
  
  
  CONCLUSIONS
  This study demonstrated that the serum HA and COMP levels were elevated in the more severe OA patients by knee ultrasonography than in the less severe patients. This suggests that the detailed pathological changes in the soft tissue and/or bone of the OA joints on ultrasonography are directly reflected by the biochemical markers measured in the peripheral blood.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Hallym University Medical College, Chuncheon, South Korea.
authors.forename: Y O
authors.initials: YO
authors.lastname: Jung
authors.forename: J-H
authors.initials: JH
authors.lastname: Do
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kang
authors.forename: S-A
authors.initials: SA
authors.lastname: Yoo
authors.forename: C-H
authors.initials: CH
authors.lastname: Yoon
authors.forename: H-A
authors.initials: HA
authors.lastname: Kim
authors.forename: C-S
authors.initials: CS
authors.lastname: Cho
authors.forename: W-U
authors.initials: WU
authors.lastname: Kim
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D064236:Cartilage Oligomeric Matrix Protein; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D064235:Matrilin Proteins; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D013583:Synovial Membrane / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D014463:Ultrasonography / Q000379:methods*
chemical_list: D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; C577553:TSP5 protein, human; D006820:Hyaluronic Acid