title: On the use of phosphoramidite ligands in copper-catalyzed asymmetric transformations with trialkylaluminum reagents.
abstract: [reaction: see text] Phosphoramidites based on BINOL readily react with trimethylaluminum in "noncoordinating" solvents, leading to the corresponding aminophosphine which is the real ligand in copper-catalyzed asymmetric transformations. This artifact explains the experimental differences in the asymmetric ring opening of meso bicyclic hydrazines using dialkylzinc or trialkylaluminum reagents as nucleophiles.
authors.affiliation: Laboratoire de Chimie Thérapeutique, UMR 8638 associée au CNRS et à l'Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 av de l'Observatoire, 75270 Paris Cedex 06, France.
authors.forename: Chloée
authors.initials: C
authors.lastname: Bournaud
authors.forename: Caroline
authors.initials: C
authors.lastname: Falciola
authors.forename: Thomas
authors.initials: T
authors.lastname: Lecourt
authors.forename: Stéphane
authors.initials: S
authors.lastname: Rosset
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis
authors.forename: Laurent
authors.initials: L
authors.lastname: Micouin