title: Gastric proliferative lesions induced by duodenogastric reflux in rats.
abstract: OBJECTIVE
  To analyze mucosal proliferation and its characteristics, through specific models of duodenogastric reflux, in the stomach of Wistar rats.
  
  
  METHODS
  Seventy-five healthy and adult male rats were divided into three groups: group I--control (n = 25 animals), submitted to gastrotomy of the posterior wall of the glandular stomach; group II--DGR (n = 25 animals), submitted to duodenogastric reflux through latero-lateral gastrojejunal anastomosis in the posterior wall of the glandular stomach and group III--DGR-P (n = 25 animals), submitted to duodenogastric reflux through the pylorus following the same procedure of group II, sectioning and closing the afferent loop. The animals were observed during 36 weeks and subsequently the mucosal lesions were analyzed, with macroscopic and microscopic examination of the prepyloric, the gastrojejunostomy and the squamous area of the stomach.
  
  
  RESULTS
  Group I did not present any kind of lesion. Macroscopic lesions of the prepyloric area in groups II and III were 0% and 20%, respectively. Macroscopic lesions of the gastrojejunal stoma in groups II and III were 36% and 88%, respectively, and 12% and 28%, respectively, in the squamous area. Microscopically, adenomatous hyperplasia (AH), squamous hyperplasia (SH) and adenocarcinoma (AC) were diagnosed. The occurrence of AH at the prepyloric area in groups II and III was 0% and 40%, respectively, and in the gastrojejunal stoma, 40% and 72%, respectively. The occurrence of SH in the squamous area in groups II and III was 12% and 20%, respectively, without statistical differences between the groups. AC was found only in three animals of groups III (12%).
  
  
  CONCLUSIONS
  The duodenogastric reflux in this experimental model caused high frequency of proliferative lesions of the gastrojejunal stoma and in the prepyloric area, while adenocarcinoma was a rare occurrence.
authors.affiliation: School of Medicine of Pouso Alegre, University of Vale do Sapucai, Brazil. mrclin@uol.com.br
authors.forename: Rosângela Lucinda Rocha
authors.initials: RL
authors.lastname: Monteiro
authors.forename: Nelson Adami
authors.initials: NA
authors.lastname: Andreollo
authors.forename: Maria Aparecida Marchesan
authors.initials: MA
authors.lastname: Rodrigues
authors.forename: Marina Raquel
authors.initials: MR
authors.lastname: Araujo
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology*; D000714:Anastomosis, Surgical; D000818:Animals; D004195:Disease Models, Animal; D004379:Duodenal Neoplasms / Q000209:etiology / Q000473:pathology*; D004383:Duodenogastric Reflux / Q000150:complications* / Q000473:pathology; D006965:Hyperplasia / Q000209:etiology / Q000473:pathology; D007583:Jejunum / Q000473:pathology / Q000601:surgery; D008297:Male; D011708:Pylorus / Q000473:pathology / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000473:pathology*