title: Transcardiac adiponectin gradient is independently related to endothelial vasomotor function in large and resistance coronary arteries in humans.
abstract: Adiponectin, an adipocyte-derived protein, has been shown to have vasculoprotective effects. This study examined the possible relationship between coronary vasomotor function and the transcardiac gradient of adiponectin, reflecting adiponectin utilization and/or accumulation in the coronary vascular bed. The epicardial diameter and blood flow response of the left anterior descending coronary artery to intracoronary infusions of ACh was analyzed in 108 consecutive subjects who had a normal coronary angiogram and left ventriculogram. Adiponectin levels were measured by ELISA in plasma obtained from the aortic root (Ao) and the anterior interventricular vein (AIV). Adiponectin levels in the AIV were lower than levels in the Ao. In multivariate linear regression analysis, the transcardiac gradient of adiponectin (Ao - AIV levels) showed a positive correlation with increases in epicardial coronary diameter and coronary blood flow in response to ACh that was independent of traditional coronary risk factors. The transcardiac gradient of adiponectin was not significantly associated with the coronary dilator response to isosorbide dinitrate and the coronary flow response to sodium nitroprusside. In other groups of patients with coronary spastic angina (n = 41) or microvascular angina (n = 32) who had impaired coronary vasomotor responses, there was no significant gradient of adiponectin between the Ao and AIV. The transcardiac gradient of adiponectin may modulate endothelial vasomotor function in large and resistance coronary arteries and may play a role in the pathogenesis of diseases presenting with coronary vasomotor dysfunction.
authors.affiliation: Dept. of Internal Medicine II, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, 409-3898 Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Takano
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kodama
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kitta
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Jyun-ei
authors.initials: JE
authors.lastname: Obata
authors.forename: Akira
authors.initials: A
authors.lastname: Mende
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kawabata
authors.forename: Yukio
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fujioka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hasebe
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kugiyama
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000368:Aged; D000787:Angina Pectoris / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D016022:Case-Control Studies; D003326:Coronary Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000294:innervation / Q000473:pathology / Q000502:physiology*; D004730:Endothelium, Vascular / Q000294:innervation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D012039:Regional Blood Flow / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology*; D014666:Vasomotor System / Q000502:physiology*
chemical_list: D052242:Adiponectin