Determination of furosemide in rat plasma using HPLC and liquid scintillation.
A rapid and convenient HPLC method for the determination of furosemide in plasma is described. The method uses a buffered mobile phase containing 22% (v/v) acetonitrile. The precision, detection limit and the correlation between the HPLC method and a liquid scintillation determination of furosemide are satisfactory. A pharmacokinetic study of furosemide in the rat is described.
Guermouche
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Institute de Chimie, USTHB, B.P. no. 9, Dar-El-Beida, Alger, Algeria.
Guermouche
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Mansouri
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Abed
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