title: Simultaneous determination of fenbendazole, its sulphoxide and sulphone metabolites with the corresponding metabolites of triclabendazole in the plasma of sheep and cattle by high-performance liquid chromatography.
abstract: Pharmacokinetic studies following the simultaneous treatment of sheep or cattle with the anthelmintics triclabendazole and fenbendazole required an assay for determining the analytes in the plasma. An extraction and clean-up procedure is described which uses a C(18) Sep Pak cartridge, involves no evaporation steps and produces a clean extract from sheep and cattle plasma in which triclabendazole, fenbendazole and their respective oxidation products may be determined by reversed-phase high-performance liquid chromatography. Results from application of the method to a pharmacokinetic study of sheep are presented.
authors.affiliation: CIBA-GEIGY Australia Limited, Western Road, Kemps Creek, N.S.W. 2171, Australia.
authors.forename: M S
authors.initials: MS
authors.lastname: Bull
authors.forename: G R
authors.initials: GR
authors.lastname: Shume