[HLA-DM gene polymorphism in Cantonese with condyloma acuminata].
OBJECTIVE
To study the polymorphism of HLA-DM gene in Cantonese patients with condyloma acuminata(CA) and determine the susceptible genetic factors of CA.


METHODS
DMA and DMB typing was performed in 98 Cantonese patients with CA and 93 healthy controls using restriction fragment length polymorphism method.


RESULTS
The gene frequencies of DMA*0101 and DMB*0101 were significantly higher in the patients than in the controls (P<0.05 and P<0.01, respectively), and gene frequency of DMA*0102 was lower in patients than in the controls (P<0.01). Genotype frequencies of HLA-DM showed no significant difference between CA patients and the controls (P>0.05).


CONCLUSIONS
DMA*0101 and DMB*0101 alleles may be the susceptibility genes or closely linked to the susceptibility gene in Cantonese patients with CA.
Yang
Wen-lin
WL
Department of Dermatology, Second Affiliated Hospital, Guangzhou Medical College, Guangzhou 510260, China. yangwenlin@21cn.com
Yang
Jian
J
Chen
Sheng-qiang
SQ
Xie
Fang-ying
FY
Huang
Xin-yu
XY
Ye
Ting
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D003218:Condylomata Acuminata / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D006681:HLA-D Antigens; C084245:HLA-DM antigens