[Saponins of polygalacic acid type from Platycodon grandiflorum].
OBJECTIVE
To isolate triterpene saponins of polygalacic acid type from the roots of Platycodon grandiflorum (Jacq.) A. DC and to identify their structures.


METHODS
The compounds were separated by means of extraction, chromatography on silica gel, MPLC and HPLC, and their structures were elucidated on the basis of spectral analyses (FAB-MS, IR, 1H NMR, 13C NMR etc.).


RESULTS
Three triterpene saponins were isolated from the roots of Platycodon grandiflorum. They were identified as 3-O-beta-D-laminaribiosyl polygalacic acid (I), 3-O-beta-D-glucopyranosyl polygalacic acid (II), polygalacin D (III), separately.


CONCLUSIONS
Compound I is a new compound, compounds II, III are known triterpene saponins. The compound I and II were isolated from the plant for the first time, which is also the monodesmoside from the plant for the first time.
Fu
Wen-wei
WW
School of Traditional Chinese Material Medica, Shenyang Pharmaceutical University, China.
Hou
Wen-bin
WB
Dou
De-qiang
DQ
Hua
Hui-ming
HM
Gui
Mao-hua
MH
Fu
Rui
R
Chen
Ying-jie
YJ
Pei
Yue-hu
YH
D008968:Molecular Conformation; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031238:Platycodon / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*
C523478:3-O-beta-D-glucopyranosyl polygalacic acid; C523477:3-O-beta-D-laminaribiosyl polygalacic acid; D012503:Saponins