title: The determination of thiomalate in physiological fluids by high-performance liquid chromatography and electrochemical detection.
abstract: Methods are described for the determination of free thiomalate in the plasma and urine of patients receiving the anti-rheumatic drug sodium aurothiomalate. Thiomalate is separated by reversed-phase chromatography and detected using a gold electrochemical cell. Plasma analyses require maximal sensitivity while urine estimations require selectivity rather than sensitivity: different phosphate buffer-methanol eluents and electrode potentials are used. On-column sensitivity for thiomalate is 40 fmol injected.
authors.affiliation: Department of Rheumatology, City Hospital, Nottingham, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Rudge
authors.forename: D
authors.initials: D
authors.lastname: Perrett
authors.forename: P L
authors.initials: PL
authors.lastname: Drury
authors.forename: A J
authors.initials: AJ
authors.lastname: Swannell