Determination of morphine in human plasma by radioimmunoassay utilising a preliminary liquid-solid extraction.
Numerous assays are available for the pharmacokinetic study of morphine. Two of these methods are compared with a new assay procedure, which involves a solid-phase extraction to clean up human plasma before radioimmunoassay allowing the determination of morphine levels to a sensitivity of 1 mugl(-1). Data are presented to show the importance of correct method choice if clinical studies are to be used in pharmacokinetic interpretations.
Quinn
K
K
Bioanalytical Department Napp Research Centre Ltd, Cambridge Science Park, Milion Road, Cambridge, UK.
Galloway
D B
DB
Leslie
S T
ST
Ness
C
C
Robertson
S
S
Shill
A
A