[Efficacy and safety of specific immunotherapy of upper airways allergic diseases caused by allergy to mites].
OBJECTIVE
The aim of this study was to evaluate the efficacy and safety of 3 years oral specific immunotherapy in patients with perannial allergic rhinitis and bronchial asthma caused by allergy to mites.


METHODS
Fifteen patients with allergic perannial rhinitis entered the study. Ten of them suffered also from bronchial asthma. During 3 years of therapy we have monitored the appearance of side effects, clinical parameters (symptoms degree and medication usage score) and immunological parameters (serum eosinophil cationic protein concentration and leukotriene C4 liberation by peripheral blood leukocytes upon in vitro specific allergens stimulation).


RESULTS
We have not observed the appearance of any adverse event, so medication has been recognized as a safe. Moreover, we have observed a lot of positive therapeutical effects--the lowering of symptoms scores, accompanied by advantageous changes in immunological parameters. However, in spite of 3 years of therapy, many patients still reported the substantial clinical symptoms, accompanied by still elevated serum ECP concentration and relatively high leukotriene C4 liberation by peripheral blood leukocytes upon in vitro stimulation by specific allergens.


CONCLUSIONS
Oral specific immunotherapy in the patients with allergic diseases of upper airways is a safe medication but leads only to moderate clinical efficacy accompanied by lowering serum ECP concentration and reducing of leukotrienes C4 liberation by peripheral blood leukocytes stimulated by specific allergens.
Medrala
Wojciech
W
Akademia Medyczna we Wrocławiu, Katedra i Klinika Chorób Wewnetrznych i Alergologii.
Wolańczyk-Medrala
Anna
A
Szczepaniak
Wioletta
W
Gietkiewicz
Krystyna
K
Murawski
Marek
M
Litwa
Marta
M
Nadobna
Grazyna
G
Gogolewski
Grzegorz
G
D000284:Administration, Oral; D000328:Adult; D000818:Animals; D040002:Dermatophagoides pteronyssinus; D047150:Eosinophil Cationic Protein / Q000097:blood; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D017997:Leukotriene C4 / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D012882:Skin Tests
D010936:Plant Extracts; D017997:Leukotriene C4; C014135:Novo-Helisen Depot; D047150:Eosinophil Cationic Protein