title: Prosthodontic treatment during active osteonecrosis related to radiation and bisphosphonate therapy: a clinical report.
abstract: Osteonecrosis of the jaws following the use of bisphosphonate drugs has been reported in the literature. Presently, there is limited evidence to establish guidelines for the prosthodontic management of patients with active osteonecrosis, a history of osteonecrosis, or medical history of using these medications. This clinical report reviews the current literature regarding bisphosphonate use, and reports the prosthodontic treatment of an edentulous patient with active osteonecrosis who had a history of oral bisphosphonate use and jaw irradiation.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, 4201 St. Antoine, UHC-5G, Detroit, MI 48201, USA. mmarunic@med.wayne.edu
authors.forename: Mark
authors.initials: M
authors.lastname: Marunick
authors.forename: Sara
authors.initials: S
authors.lastname: Gordon
mesh_terms: D019386:Alendronate / Q000009:adverse effects*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D003827:Denture, Complete, Upper; D005260:Female; D006801:Humans; D008336:Mandibular Diseases / Q000150:complications / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy; D009066:Mouth, Edentulous / Q000150:complications / Q000534:rehabilitation*; D010020:Osteonecrosis / Q000150:complications / Q000209:etiology* / Q000601:surgery; D010025:Osteoradionecrosis / Q000150:complications / Q000209:etiology / Q000601:surgery
chemical_list: D050071:Bone Density Conservation Agents; D019386:Alendronate