Nimbolide and isonimbolide.
Nimbolide 1, a potent molecule of biological significance, was isolated. Attempts were made to cleave the ether linkage in nimbolide using boron trifluoride etherate in the presence of tetrabutyl ammonium bromide so as to generate a ring-opened structure akin to azadirachtins, which are known to possess excellent antifeedant properties. However, a novel rearranged product was envisaged during the course of the reaction, which was determined as isonimbolide 2-a structural isomer of nimbolide through spectroscopic methods.
Anitha
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Asthagiri Herbal Research Foundation, 7/1, Thirumazhisai Street, Sundaram Colony, East Tambaram, Chennai, 600 059, Tamil Nadu, India. asthagiri@vsln.net
Josepha Lourdu Raj
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Narasimhan
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Anand Solomon
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Rajan
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D006801:Humans; D036701:Limonins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010946:Plants, Medicinal
D036701:Limonins; C042198:nimbolide