title: Accelerated atheroma in the antiphospholipid syndrome.
abstract: Increased cardiovascular morbidity and mortality due to the pre-mature or accelerated development of atherosclerosis has been reported in patients with systemic autoimmune diseases such as systemic lupus erythematosus. These findings motivated a great deal of research into the role of autoimmunity in atherogenesis. The relationship between atherosclerosis and cholesterol metabolism to atherosclerosis has been well established. However, the participation of newer inflammatory and immunologic mechanisms are emerging as relevant factors for the initiation and progression of atherosclerotic lesions.
authors.affiliation: Department of Cell Chemistry, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. eijimatu@md.okayama-u.ac.jp
authors.forename: Eiji
authors.initials: E
authors.lastname: Matsuura
authors.forename: Kazuko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masako
authors.initials: M
authors.lastname: Tabuchi
authors.forename: Luis R
authors.initials: LR
authors.lastname: Lopez
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D008078:Cholesterol, LDL / Q000276:immunology; D006801:Humans; D013927:Thrombosis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology
chemical_list: D017152:Antibodies, Antiphospholipid; D008078:Cholesterol, LDL