title: qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.
abstract: We screened 313 ceftazidime-resistant Enterobacteriaceae isolates obtained in the United States from 1999 to 2004 for all three known qnr genes. A qnr gene was present in 20% of Klebsiella pneumoniae isolates, 31% of Enterobacter sp. isolates, and 4% of Escherichia coli isolates. qnrA and qnrB occurred with equivalent frequencies and, except for qnrB in enterobacters, were stable over time. qnrS was absent.
authors.affiliation: Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114-2696, USA.
authors.forename: A
authors.initials: A
authors.lastname: Robicsek
authors.forename: J
authors.initials: J
authors.lastname: Strahilevitz
authors.forename: D F
authors.initials: DF
authors.lastname: Sahm
authors.forename: G A
authors.initials: GA
authors.lastname: Jacoby
authors.forename: D C
authors.initials: DC
authors.lastname: Hooper
mesh_terms: D017677:Age Distribution; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D002442:Ceftazidime / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D004926:Escherichia coli; D005260:Female; D005798:Genes, Bacterial; D006801:Humans; D007297:Inpatients; D007711:Klebsiella pneumoniae; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008969:Molecular Sequence Data; D015995:Prevalence; D012189:Retrospective Studies; D019779:Salmonella enterica / Q000145:classification / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014481:United States / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002442:Ceftazidime