title: Transjugular intrahepatic portosystemic shunt placement in patients with cirrhosis and concomitant portal vein thrombosis.
abstract: OBJECTIVE
  To determine the safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) creation in patients with liver cirrhosis complicated by thrombosed portal vein.
  
  
  METHODS
  This study reviewed 15 cases of TIPS creation in 15 cirrhotic patients with portal vein thrombosis at our institution over an 8-year period. There were 2 women and 13 men with a mean age of 53 years. Indications were refractory ascites, variceal hemorrhage, and refractory pleural effusion. Clinical follow-up was performed in all patients.
  
  
  RESULTS
  The technical success rate was 75% (3/4) in patients with chronic portal vein thrombosis associated with cavernomatous transformation and 91% (10/11) in patients with acute thrombosis or partial thrombosis, giving an overall success rate of 87%. Complications included postprocedural encephalopathy and localized hematoma at the access site. In patients with successful shunt placement, the total follow-up time was 223 months. The 30-day mortality rate was 13%. Two patients underwent liver transplantation at 35 days and 7 months, respectively, after TIPS insertion. One patient had an occluded shunt at 4 months with an unsuccessful revision. The remaining patients had functioning shunts at follow-up.
  
  
  CONCLUSIONS
  TIPS creation in thrombosed portal vein is possible and might be a treatment option in certain patients.
authors.affiliation: Department of Radiology, Section of Interventional Radiology, The University of Chicago, 5841 South Maryland Avenue MC 2026, Chicago, IL 60637, USA. tgvanha@radiology.bsd.uchicago.edu
authors.forename: Thuong G
authors.initials: TG
authors.lastname: Van Ha
authors.forename: Justin
authors.initials: J
authors.lastname: Hodge
authors.forename: Brian
authors.initials: B
authors.lastname: Funaki
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lorenz
authors.forename: Jordan
authors.initials: J
authors.lastname: Rosenblum
authors.forename: Christopher
authors.initials: C
authors.lastname: Straus
authors.forename: Jeff
authors.initials: J
authors.lastname: Leef
mesh_terms: D000328:Adult; D000368:Aged; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000601:surgery; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D020246:Venous Thrombosis / Q000601:surgery*