title: [The importance of hypothermia in the preconditioning increase of ischemic tolerance to global cerebral ischemia].
abstract: Various types of preconditioning including the main hypoxia (hypoxic, circulatory, hematic/hypemic and tissue/histotoxic), agonists of adenosine A-receptors and openers of K(ATP)-channels induce a hypothermia. A-agonists act through A1-receptors, CoCl2 and NiCl2--via endogenous adenosine and activation by it A1-receptors. The developing hypothermia correlates with neuroprotective effect and is important, but not the only mechanism of tolerance increase to global ischemia. At the similar hypothermia the preconditioning effect excels more frequently an influence of external cooling.
authors.forename: V I
authors.initials: VI
authors.lastname: Kulikovskiĭ
authors.forename: T V
authors.initials: TV
authors.lastname: Gavrilina
authors.forename: L N
authors.initials: LN
authors.lastname: Minakina
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Kovtun
mesh_terms: D058907:Adenosine A1 Receptor Agonists; D000818:Animals; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000378:metabolism*; D003035:Cobalt / Q000494:pharmacology; D005260:Female; D007036:Hypothermia, Induced; D019194:Ischemic Preconditioning; D008297:Male; D051379:Mice; D009532:Nickel / Q000494:pharmacology
chemical_list: D058907:Adenosine A1 Receptor Agonists; D003035:Cobalt; C022838:nickel chloride; D009532:Nickel; C018021:cobaltous chloride