title: [The usefulness of tizanidine. A one-year follow-up of the treatment of spasticity in infantile cerebral palsy].
abstract: BACKGROUND
  The cerebral palsy has the first place of physical handicap in children (type spastic, 88%). Tizanidine imidazole derivative is centrally acting as a a2-adrenergic agonist.
  
  
  OBJECTIVE
  To demonstrate clinically the effectiveness of tizanidine in the decrease of the spasticity.
  
  
  METHODS
  We assigned randomly in a double blind study 10 children treated with tizanidine (0.05 mg/kg/day) and 30 with placebo for a 6-month period, after which they were unified in the group of tizanidine. The dependent variables were spasticity, Ashworth scale, posture tone scale, reflex scale and liver function test.
  
  
  RESULTS
  The spasticity and the reflex decreased in the group of tizanidine an 78.85% in comparison with a 7.64% in the group of placebo (p = 0.0001); in the monitoring of 6 months 35 patients reduced this to 78.2% (p= 0.0001). The duration of effectiveness of tizanidine in four patients was two months and they never returned to their appraisal basal. Without reported adverse effects, the liver function test remains normal.
  
  
  CONCLUSIONS
  Tizanidine produces a significant reduction of the spasticity in children without adverse effects, having a high percentage of acceptance to the prescribe dose.
authors.affiliation: División de Rehabilitación Pediátrica, Servicio de Parálisis Cerebral Infantil y Estimulación Temprana, Centro Nacional de Rehabilitación, Tlalpan, Mexico DF, Mexico. ascelayv@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Vásquez-Briceño
authors.forename: M E
authors.initials: ME
authors.lastname: Arellano-Saldaña
authors.forename: S R
authors.initials: SR
authors.lastname: León-Hernández
authors.forename: M G
authors.initials: MG
authors.lastname: Morales-Osorio
mesh_terms: D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D002547:Cerebral Palsy / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D003000:Clonidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy / Q000209:etiology; D011446:Prospective Studies
chemical_list: D000316:Adrenergic alpha-Agonists; D009125:Muscle Relaxants, Central; C023754:tizanidine; D003000:Clonidine