title: Treatment of anthracycline extravasation with dexrazoxane -- clinical experience.
abstract: BACKGROUND
  Accidental extravasation is a severe complication when administering anthracyclines. We describe 3 cases of extravasation with 3 different anthracyclines.
  
  
  METHODS
  One patient came from another hospital for a second opinion after an epirubicin extravasation. Only surgical debridement of the necrotic tissue was possible. The other two extravasations occurred during treatment with doxorubicin and doxorubicin- EMCH, respectively, in our department. Both patients were treated with dexrazoxane within 6 h of the event.
  
  
  RESULTS
  The 2 patients treated with dexrazoxane recovered completely without any sequelae.
  
  
  CONCLUSIONS
  Treatment of antracycline extravasation with dexrazoxane is potentially useful and safe.
authors.affiliation: Tumor Biology Center at the Albert Ludwigs University, Freiburg i.Br., Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Frost
authors.forename: Daniela
authors.initials: D
authors.lastname: Gmehling
authors.forename: Marc
authors.initials: M
authors.lastname: Azemar
authors.forename: Clemens
authors.initials: C
authors.lastname: Unger
authors.forename: Klaus
authors.initials: K
authors.lastname: Mross
mesh_terms: D000368:Aged; D018943:Anthracyclines / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011929:Razoxane / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D011929:Razoxane