title: Biocompatibility of a new radiopaque iodine-containing acrylic bone cement.
abstract: Radiopacity in the vast majority of the commercially available acrylic bone cements that are used clinically is provided by particles of either BaSO(4) or ZrO(2). Literature reports have shown these agents to have a detrimental effect on some mechanical properties of the cements as well as on its biological response. We, therefore, have developed a new type of bone cement, for which radiopacity results from the presence of an iodine-containing methacrylic copolymer. The focus of the present work was the comparison of the biocompatibility of this new cement and a commercially available cement that contains barium sulfate. In vitro experiments show that both cements are cytocompatible materials, for which no toxic leachables are found. Implantation of the cements in a rabbit for three months resulted in the occasional presence of a thin fibrous tissue at the cement-bone interface, which is common for acrylic bone cements. Consideration of all the results led to the conclusion that the new cement is as biocompatible as the BaSO(4)-containing one.
authors.affiliation: Centre for Biomaterials Research, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands.
authors.forename: Catharina S J
authors.initials: CS
authors.lastname: van Hooy-Corstjens
authors.forename: Sjoerd K
authors.initials: SK
authors.lastname: Bulstra
authors.forename: Menno L W
authors.initials: ML
authors.lastname: Knetsch
authors.forename: Piet
authors.initials: P
authors.lastname: Geusens
authors.forename: Roel
authors.initials: R
authors.lastname: Kuijer
authors.forename: Leo H
authors.initials: LH
authors.lastname: Koole
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D002478:Cells, Cultured; D003287:Contrast Media; D005269:Femur / Q000473:pathology / Q000601:surgery; D006801:Humans; D066298:In Vitro Techniques; D007455:Iodine / Q000737:chemistry; D007462:Iodobenzenes / Q000737:chemistry; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D016348:Osseointegration; D010006:Osteoblasts / Q000166:cytology; D011109:Polymethacrylic Acids / Q000737:chemistry; D011817:Rabbits
chemical_list: C458727:2-(4-iodobenzoyl)-oxo-ethylmethacrylate; D001843:Bone Cements; D003287:Contrast Media; D007462:Iodobenzenes; D008689:Methacrylates; D011109:Polymethacrylic Acids; D007455:Iodine