title: High-frequency percussive ventilation improves oxygenation in trauma patients with acute respiratory distress syndrome: a retrospective review.
abstract: BACKGROUND
  High-frequency percussive ventilation (HFPV), a hybrid of conventional mechanical ventilation and high-frequency oscillatory ventilation, has been used to salvage patients with persistent hypoxemia on conventional mechanical ventilation. We hypothesized that oxygenation would improve in injured patients with severe hypoxemia who were converted to HFPV after initial management with conventional ventilation.
  
  
  METHODS
  Chart review identified patients with acute respiratory distress syndrome (ARDS) managed with HFPV. Oxygenation parameters (oxygenation index, OI; Pao(2)/Fio(2) ratio, P/F) and mean airway pressures (mPaw) were recorded at baseline and at 1 to 4, 8 to 12, and 12 to 24 hours after initiation of HFPV. Values at baseline and each time point after conversion to HFPV were compared by using analysis of variance or Kruskal-Wallis tests.
  
  
  RESULTS
  Twelve patients, over 24 months, were reviewed. Baseline measurements were OI: 42.2 +/- 33, P/F: 70 +/- 31, (median +/- interquartile range), and mPaw: 29 +/- 8 (mean +/- standard deviation) cm H(2)O. After initiation of HFPV, mPaw did not differ from baseline. There was an improvement in OI (P = .01) from baseline at 12 to 24 hours after initiation of HFPV and in P/F at 12 to 24 hours (P = .002) and 8 to 12 hours (P = .001) after initiation of HFPV.
  
  
  CONCLUSIONS
  HFPV may improve oxygenation in patients with ARDS without a concomitant increase in mPaw. A randomized trial of HFPV versus conventional ventilation in trauma patients is needed.
authors.affiliation: Department of Surgery, University of Texas Southwestern Medical Center at Dallas, 75390-9158, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Eastman
authors.forename: Dean
authors.initials: D
authors.lastname: Holland
authors.forename: Jason
authors.initials: J
authors.lastname: Higgins
authors.forename: Brian
authors.initials: B
authors.lastname: Smith
authors.forename: Jennifer
authors.initials: J
authors.lastname: Delagarza
authors.forename: Craig
authors.initials: C
authors.lastname: Olson
authors.forename: Scott
authors.initials: S
authors.lastname: Brakenridge
authors.forename: Kousta
authors.initials: K
authors.lastname: Foteh
authors.forename: Randall
authors.initials: R
authors.lastname: Friese
mesh_terms: D000328:Adult; D005500:Follow-Up Studies; D006612:High-Frequency Ventilation / Q000379:methods*; D006801:Humans; D055370:Lung Injury; D010101:Oxygen Consumption; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D012189:Retrospective Studies; D013898:Thoracic Injuries / Q000150:complications* / Q000378:metabolism; D015599:Trauma Severity Indices; D016896:Treatment Outcome; D014949:Wounds, Nonpenetrating / Q000150:complications* / Q000378:metabolism