Chemokines and pain.
Chemokines are chemotactic mediators controlling cell trafficking under physiological and pathological conditions. Recently, it has been discovered that chemokines are not only important in various inflammatory conditions, but that they also play a role in pain and analgesia. Chemokine function in the periphery has been evaluated under non-inflammatory, inflammatory and neuropathic conditions. While many studies have examined the hyperalgesic action of chemokines, increasing evidence points to the antinociceptive properties of chemokines. This review focuses on the role of chemokines in the peripheral tissue.
Rittner
Heike L
HL
Klinik für Anästhesiologie und Operative Intensivmedizin, Charité-Universitätsmedizin Berlin, Germany. heike.rittner@charite.de
Brack
Alexander
A
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D018925:Chemokines / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology; D010146:Pain / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000150:complications
D000700:Analgesics; D018925:Chemokines