Functional roles of the NTS2 and NTS3 receptors.
Neurotensin exerts its actions in the central nervous system and the periphery through three identified receptors. Two of them, the NTS2 and NTS3, display unusual properties either because of their complex signal transduction mechanisms (NTS2) or because of their structural composition as a non-G-protein-coupled receptor (NTS3). Here, we review the transduction mechanisms, cellular trafficking, and potential physiological roles of these two unconventional receptors.
Mazella
Jean
J
Institut de Pharmacologie Moléculaire et Cellulaire, Unité Mixte de Recherche 6097 du Centre National de la Recherche Scientifique, et de l'Université de Nice Sophia Antipolis, Sophia Antipolis, 06560 Valbonne, France. mazella@ipmc.cnrs.fr
Vincent
Jean-Pierre
JP
D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D001693:Biological Transport, Active; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D018028:Receptors, Neurotensin / Q000145:classification / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D000099183:Sortilin
D033942:Adaptor Proteins, Vesicular Transport; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D018028:Receptors, Neurotensin; D011994:Recombinant Proteins; D000099183:Sortilin