title: Sodium valproate vs phenytoin in status epilepticus: a pilot study.
abstract: Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.
authors.affiliation: Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India. drukmisra@rediffmail.com
authors.forename: U K
authors.initials: UK
authors.lastname: Misra
authors.forename: Jayantee
authors.initials: J
authors.lastname: Kalita
authors.forename: Rajesh
authors.initials: R
authors.lastname: Patel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage*; D010865:Pilot Projects; D013226:Status Epilepticus / Q000188:drug therapy* / Q000453:epidemiology*; D016896:Treatment Outcome; D014635:Valproic Acid / Q000008:administration & dosage*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid; D010672:Phenytoin