[Inhibition of quercetin on liver fibrosis due to Schistosoma japonicum infection and on the expression of immediate early gene and metalloproteinase 1 inhibitor in liver tissue of mice].
Quercetin and praziquantel were used to treat mice with hepatic fibrosis due to Schistosoma japonicum infection. Quercetin treatment obviously relieved the degree of hepatic fibrosis, significantly reduced the expression of immediate early gene, tissue inhibitor of metalloproteinase 1 (TIMP 1), types I and III collagen compared to the control. The expression of c-jun mRNA, type I and type III collagen were reduced significantly compared to the group treated with praziquantel, whereas no difference in the expression of c-fos mRNA and TIMP1 between the two groups, indicating that quercetin may have better effect on schistosomal liver fibrosis than praziquantel in the long term.
Xu
Biao
B
Division of Infection, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
He
Sheng-song
SS
Han
Chun-rong
CR
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D024042:Collagen Type I / Q000096:biosynthesis; D024061:Collagen Type III / Q000096:biosynthesis; D005260:Female; D005355:Fibrosis / Q000209:etiology; D015870:Gene Expression / Q000187:drug effects; D017781:Genes, Immediate-Early / Q000235:genetics*; D007150:Immunohistochemistry; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D011794:Quercetin / Q000494:pharmacology* / Q000627:therapeutic use; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012549:Schistosoma japonicum / Q000187:drug effects*; D012554:Schistosomiasis japonica / Q000150:complications / Q000188:drug therapy* / Q000469:parasitology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000096:biosynthesis*
D000975:Antioxidants; D024042:Collagen Type I; D024061:Collagen Type III; D012333:RNA, Messenger; D019715:Tissue Inhibitor of Metalloproteinase-1; D011794:Quercetin