title: [Cardiac sympathetic innervation in patients with ventricular arrhythmias: an assessment by 123I-metaiodobenzylguanidine scintigraphy].
abstract: The aim of this study was to determine the state of sympathetic innervation in patients with ventricular arrhythmias (VA) using 123I-metaiodobenzylguanidine 123I -MIBG) scintigraphy. Fifty six patients (26 men and 30 women, mean age 37.4+/-11,6) underwent single-photon emission computed tomography (SPECT) imaging and planner scintigraphy after injection of 123I-MIBG (activity 148 MBq). They form three groups. Thirty patients with idiopathic VA (IVA) were included in group I: 14 patients with ventricular extrasystoles (VE) and 16 - with ventricular tachycardias (VT). Group II was formed by 17 patients (with dilated cardiomyopathy, n=7 and chronic myocarditis, n=10), 6 of them had VE and 11 - VT. The control group III was formed by 9 healthy subjects with structurally normal heart without VA. We analyzed early (30 minutes) and delayed (4 hours) images after 123I-MIBG administration. The global sympathetic activity (SA) was assessed by heart/mediastinum ratio and washout rate. Regional SA was assessed by extent and severity of defect. In group I 25 of 30 patients (83.3%) had regional SA abnormalities significantly different from controls (p<0.001). At the same time global uptake of 123I-MIBG in this group was not affected. In group II regional SA abnormalities were revealed in all patients (100%) and global reduction of 123I-MIBG uptake - in 14 patients (82.4%). Regional and global SA abnormalities in group II were different from controls (p<0.0001) and patients with IVA (p<0.001). There was no difference in SA abnormalities between patients with VE and VT. Our results suggest that patients with different VA have abnormalities of sympathetic innervation, including patients with structurally normal heart.
authors.forename: N V
authors.initials: NV
authors.lastname: Loladze
authors.forename: S P
authors.initials: SP
authors.lastname: Golitsyn
authors.forename: L E
authors.initials: LE
authors.lastname: Samoĭlenko
authors.forename: M S
authors.initials: MS
authors.lastname: Bekbosynova
authors.forename: D S
authors.initials: DS
authors.lastname: Novikova
authors.forename: D S
authors.initials: DS
authors.lastname: Nikitina
authors.forename: T Ia
authors.initials: TIa
authors.lastname: Nikitina
authors.forename: V B
authors.initials: VB
authors.lastname: Sergienko
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000294:innervation* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D019275:Radiopharmaceuticals; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017180:Tachycardia, Ventricular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D018879:Ventricular Premature Complexes / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine