Hemiextinction induced by transcranial magnetic stimulation over the right temporo-parietal junction.
Whereas it is widely accepted that the parietal cortex is crucial for visual attention, the role of the temporal cortex and the temporo-parietal junction (TPJ) is less clear. There are clinical reports of patients with lesions in different posterior temporal areas which exhibit contralateral visual neglect but this syndrome seems to be less frequent than in patients with parietal lesions. In a previous study, we could show that single-pulse transcranial magnetic stimulation (TMS) over the right inferior parietal cortex is capable to induce both neglect-like and extinction-like impairments of performance in normal subjects. In the present study, we used this method to examine the functional role of the superior temporal gyrus (STG) and the TPJ of the right hemisphere for visuo-spatial attention. Healthy volunteers were asked to detect small dots appearing for 40 ms unilaterally on right or left side or bilaterally on a computer screen. TMS was applied over the TPJ or STG. TMS over the TPJ induced an extinction-like behavioral pattern to the contralateral hemifield. TMS over the STG had no effect. The results demonstrate a functional involvement of the TPJ in visuo-attentional processing of competing stimuli in both hemifields. This region is part of the cortical network mediating stimulus-driven attention which is relevant for processing of competing stimuli.
Meister
I G
IG
Department of Neurology, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany. igmeister@gmx.de
Wienemann
M
M
Buelte
D
D
Grünewald
C
C
Sparing
R
R
Dambeck
N
N
Boroojerdi
B
B
D000328:Adult; D001288:Attention / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D010296:Parietal Lobe / Q000503:physiopathology*; D010468:Perceptual Disorders / Q000209:etiology*; D010775:Photic Stimulation / Q000379:methods; D013028:Space Perception / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000009:adverse effects*