Prediction of the concentrations in rat tissues of the intravenous anaesthetic methohexital from a nonlinear pharmacokinetic model.
A nonlinear pharmacokinetic model that describes the tissue distribution of intravenous anaesthetics was evaluated against experimental values for methohexital in the rat. There was excellent agreement between experimental and theoretical values for brain tissue, and good agreement for blood and adipose tissue. Agreement for lean tissue was good if it was assumed that some adipose tissue was present in skeletal muscle. Agreement was poor for all other visceral tissues. The experimental results justify further development of this mathematical model for use in accounting for differences in tissue distribution of anaesthetics, especially under various physiological conditions.
Wynn
R L
RL
Department of Oral Biology, University of Kentucky, Lexington, KY 40506, USA.
Gillis
P P
PP
Lovelace
G
G
O'Reilly
J E
JE