New developments: a look to the future.
Inflammatory cytokines plus the human immunodeficiency virus Tat protein apparently trigger the development of early Kaposi's sarcoma. Activated spindle cells provide a self-perpetuating, autocrine-supported mechanism for further development of hyperplastic lesions. In more advanced stages, a true neoplastic process may develop.
Ensoli
B
B
Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
Gallo
R C
RC
Fiorelli
V
V
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D016207:Cytokines / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D015696:Gene Products, tat / Q000378:metabolism; D006801:Humans; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000378:metabolism; D054322:tat Gene Products, Human Immunodeficiency Virus
D016207:Cytokines; D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus