A cytotoxic saponin from Albizia julibrissin.
A new triterpenoidal saponin (1: Julibroside J(21)) with a xylopyranosyl moiety located at its C-21 side chain was isolated from Albizia julibrissin DURAZZ. (Leguminosae), and its structure was determined on the basis of comprehensive spectroscopic analyses. Compound 1 showed marked inhibitory action against Bel-7402 cancer cell line at 10 microg/ml.
Zou
Kun
K
Hubei Key Laboratory of Natural Product Research and Development, Chemistry and Life Science College, China Three Gorges University, Yichang 443002, P.R. China. kzou@ctgu.edu.cn
Zhao
Yu-Ying
YY
Zhang
Ru-Yi
RY
D031289:Albizzia / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D012503:Saponins; C514002:julibroside J(21)