A case report of Clarkson's disease: If you don't know it, you'll miss it.
The systemic capillary leak syndrome (SCLS), also known as Clarkson's disease, is a rare disorder characterized by paroxysmal capillary hyperpermeability with a shift of plasma fluid from the intravascular to the interstitial space. A 35-year-old previously healthy woman was admitted with rapidly developing hypovolemic shock syndrome, rhabdomyolysis, and diffuse edema. Laboratory analysis revealed a severe hemoconcentration, renal insufficiency, and paraproteinemia. After exclusion of infection, allergy, burning or drug-induced conditions, the clinical presentation was consistent with the diagnosis of SCLS. Though this is a rare entity, the substantial morbidity and mortality associated with it necessitate the physician's awareness in order to provide timely therapy. This report is meant to enhance awareness of SCLS.
Bonadies
Nicolas
N
Department of Internal Medicine, University Hospital Bern, 3010 Bern, Switzerland.
Baud
Patricia
P
Peter
Hans-Jakob
HJ
Buergi
Ulrich
U
Mueller
Beatrice U
BU