title: Modular synthesis of heterocyclic carbene precursors.
abstract: A series of N-heterocyclic carbene precursors, containing an imidazoline or tetrahydropyrimidine framework, were prepared from omega-chloroalkanoyl chlorides. The sequential attachment of nitrogen nucleophiles and subsequent ring closure gave, depending on the reagents used, either the desired dihydroimidazolium and tetrahydropyrimidinium salts or their parent heterocycles. In this latter case, the second substituent was introduced in an alkylation step. The preparation of carbene precursors bearing chiral or bulky substituents was acieved with comparable efficiency.
authors.affiliation: Institute of Chemistry, Eötvös Lorand University, Pazmany Péter s. 1/A, H-1117 Budapest, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Paczal
authors.forename: Attila C
authors.initials: AC
authors.lastname: Bényei
authors.forename: Andras
authors.initials: A
authors.lastname: Kotschy