Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.
Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.
Ahn
Jin Hee
JH
Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon, 305-600, Republic of Korea.
Shin
Mi Sik
MS
Jung
Sun Ho
SH
Kang
Seung Kyu
SK
Kim
Kwang Rok
KR
Rhee
Sang Dal
SD
Jung
Won Hoon
WH
Yang
Sung Don
SD
Kim
Seung Jun
SJ
Woo
Joo Rang
JR
Lee
Jeong Hyung
JH
Cheon
Hyae Gyeong
HG
Kim
Sung Soo
SS
D000818:Animals; D018360:Crystallography, X-Ray; D006801:Humans; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D047495:PPAR gamma / Q000819:agonists* / Q000737:chemistry*
C513010:1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester; D007192:Indenes; D008024:Ligands; D047495:PPAR gamma