title: Association of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1) polymorphisms with pig growth and fat deposition traits.
abstract: The aim of this study was to analyse the combined effect of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1) polymorphisms on growth and fatness traits in Duroc pigs. No significant interaction was observed between MC4R and HMGA1 for back-fat traits. An additive mode of inheritance of both gene effects was found for average daily gain and lean meat content. Maximum mean differences from combined genotypic effects were over 2 mm for back fat, 70 g/day for average daily gain and 2% for lean meat content. Therefore, utilization of polymorphisms in both MC4R and HMGA1 for marker-assisted selection could result in an economic benefit to the pig industry.
authors.affiliation: Department of Animal Science, Chungbuk National University, Cheongju, Korea. kwanskim@chungbuk.ac.kr
authors.forename: K S
authors.initials: KS
authors.lastname: Kim
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.forename: H Y
authors.initials: HY
authors.lastname: Shin
authors.forename: B H
authors.initials: BH
authors.lastname: Choi
authors.forename: C K
authors.initials: CK
authors.lastname: Lee
authors.forename: J J
authors.initials: JJ
authors.lastname: Kim
authors.forename: B W
authors.initials: BW
authors.lastname: Cho
authors.forename: T-H
authors.initials: TH
authors.lastname: Kim
mesh_terms: D000818:Animals; D050218:Body Fat Distribution; D005838:Genotype; D024003:HMGA Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D013552:Swine / Q000033:anatomy & histology / Q000235:genetics / Q000254:growth & development*
chemical_list: D024003:HMGA Proteins; D044105:Receptor, Melanocortin, Type 4