title: Contribution to the methodology of optimization and in-process control of some physical properties of pharmaceutical bulk substances and granulates.
abstract: Many experts consider drug analysis exclusively as a chemical measuring technique. In the pharmaceutical industry, physical and physico-chemical parameters form an integrated part of the quality specification, because they play an essential role both in quality assurance and in the technical and economic aspects of production on the commercial scale. Such physical and physico-chemical properties are analysed by special, non-chemical methods. In their programme of systematic research in this field, the authors have elaborated new methods to test some essential properties of powders and granulates used in the production of compressed tablets. The following test and production methods have been developed: (i) the determination of flowing-sliding characteristics of granulates based on the measurement of the mass-flow (g s(-1)) and mass-flow density (g s(-1) cm(-2)); (ii) the determination of optimum granulometric parameters with regard to tablet diameter; (iii) the direct determination of the temperature-dependent equilibrium vapour pressure; and (iv) the compression of tablets under controlled temperature.
authors.affiliation: Chemical Works of Gedeon Richter Ltd, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Dávid
authors.forename: P
authors.initials: P
authors.lastname: Nagy
authors.forename: J
authors.initials: J
authors.lastname: Pogány
authors.forename: I
authors.initials: I
authors.lastname: Rácz
authors.forename: G
authors.initials: G
authors.lastname: Takács