title: Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma.
abstract: BACKGROUND
  This report analysed the outcome of patients undergoing surgery for oral squamous cell carcinoma in order to identify the prognostic value of several factors.
  
  
  METHODS
  A total of 245 patients were studied who had undergone surgery for oral squamous cell carcinoma between 1989 and 2002, of whom 109 had received postoperative radiation therapy.
  
  
  METHODS
  For each patient, personal data, alcohol and tobacco consumption, symptoms, histological findings, treatment, and outcome were recorded and analysed statistically. Survival curves were calculated using the Kaplan-Meier algorithm, and the difference in survival among subgroups was examined.
  
  
  RESULTS
  The overall 5-year survival rate in the 245 patients was 63% (72.5% at 3 years). The differences in the 5-year survival were significant (p<0.05) for the site of origin, N and pN status, TNM stage, grading, status of the resection margins, osseous infiltration, and perineural invasion. Vascular involvement as a discriminator was not statistically significant. In patients undergoing radiation therapy, only perineural invasion negatively influenced the 5-year survival prognosis (p<0.01).
  
  
  CONCLUSIONS
  The overall survival rate was within the (previously) reported range. The prognostic value of many parameters is widely recognized; the combined evaluation of 'composite factors' is promising.
authors.affiliation: Division of Maxillofacial Surgery, Giovanni Battista Hospital, University of Turin, Italy. paologrz@tiscalinet.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Garzino-Demo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dell'Acqua
authors.forename: Paola
authors.initials: P
authors.lastname: Dalmasso
authors.forename: Massimo
authors.initials: M
authors.lastname: Fasolis
authors.forename: Gian Marco
authors.initials: GM
authors.lastname: La Terra Maggiore
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Ramieri
authors.forename: Sid
authors.initials: S
authors.lastname: Berrone
authors.forename: Monica
authors.initials: M
authors.lastname: Rampino
authors.forename: Marina
authors.initials: M
authors.lastname: Schena
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D037981:Neck Dissection / Q000401:mortality; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D015996:Survival Rate; D016896:Treatment Outcome