Reaction of N-monosubstituted hydrazones with nitroolefins: a novel regioselective pyrazole synthesis.
A novel regioselective synthesis of substituted pyrazoles from N-monosubstituted hydrazones and nitroolefins is described. The reaction is performed in a one-pot manner and the yields range from moderate to excellent. A key nitropyrazolidine intermediate is characterized and a plausible mechanism is proposed.
Deng
Xiaohu
X
Department of Drug Discovery, Johnson & Johnson Pharmaceutical R&D LLC, 3210 Merryfield Row, San Diego, California 92121, USA. xdeng@prdus.jnj.com
Mani
Neelakandha S
NS
D000475:Alkenes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis*
D000475:Alkenes; D006835:Hydrazones; D009574:Nitro Compounds; D011720:Pyrazoles