Treatment of anthracycline extravasation with dexrazoxane -- clinical experience.
BACKGROUND
Accidental extravasation is a severe complication when administering anthracyclines. We describe 3 cases of extravasation with 3 different anthracyclines.


METHODS
One patient came from another hospital for a second opinion after an epirubicin extravasation. Only surgical debridement of the necrotic tissue was possible. The other two extravasations occurred during treatment with doxorubicin and doxorubicin- EMCH, respectively, in our department. Both patients were treated with dexrazoxane within 6 h of the event.


RESULTS
The 2 patients treated with dexrazoxane recovered completely without any sequelae.


CONCLUSIONS
Treatment of antracycline extravasation with dexrazoxane is potentially useful and safe.
Frost
Annette
A
Tumor Biology Center at the Albert Ludwigs University, Freiburg i.Br., Germany.
Gmehling
Daniela
D
Azemar
Marc
M
Unger
Clemens
C
Mross
Klaus
K
D000368:Aged; D018943:Anthracyclines / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011929:Razoxane / Q000627:therapeutic use*; D016896:Treatment Outcome
D018943:Anthracyclines; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D011929:Razoxane