title: Simple diamine- and triamine-protonic acid catalysts for the enantioselective Michael addition of cyclic ketones to nitroalkenes.
abstract: Simple, chiral, pyrrolidine-based diamine and triamine derivatives that incorporate the secondary-secondary diamine motif are efficient catalysts for the highly diastereoselective and enantioselective Michael addition of cyclic ketones to 2-nitrovinyl arenes. The highest selectivities are obtained when these catalysts are used in conjunction with protonic acids. Steric factors in the substrate and the size of the acid additive play an important role in stereoselection.
authors.affiliation: Department of Chemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3X7. spansare@mun.ca
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Pansare
authors.forename: Keyur
authors.initials: K
authors.lastname: Pandya