Neuronal loss in FIV-MD infected cats.
Previously, this laboratory has shown that the Maryland strain of feline immunodeficiency virus (FIV-MD) causes neurological disease in cats similar to human immunodeficiency virus type 1 (HIV-1) in people. Using morphometrical methods on neocortical histologic sections we now show a significant loss of neurons in FIV-MD infected cats compared to age-matched uninfected controls. The neuronal populations affected resembles those lost in HIV-1 infection of the brain in published reports, providing further evidence for the utility of FIV-MD infection as a model for HIV-1 infections of the brain.
Buck
W R
WR
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Podell
M
M
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000821:virology; D002415:Cats; D004195:Disease Models, Animal; D016181:Feline Acquired Immunodeficiency Syndrome / Q000473:pathology*; D005260:Female; D016089:Immunodeficiency Virus, Feline; D009474:Neurons / Q000473:pathology* / Q000821:virology; D012016:Reference Values