title: Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder.
abstract: OBJECTIVE
  The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study.
  
  
  METHODS
  Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either antidepressants, mood stabilizers, or no medication for a minimum of 4 weeks after delivery.
  
  
  RESULTS
  Two (18.2%) of the women in the OLZ group experienced a postpartum mood episode, whereas eight (57.1%) of the women in the No-OLZ group did.
  
  
  CONCLUSIONS
  The role of OLZ in the prophylaxis of PP and mood episodes, particularly in women at high risk, clearly warrants further investigation.
authors.affiliation: Department of Psychiatry and Obstetrics & Gynecology, University of Western Ontario, Ontario, Canada. vsharma@uwo.ca
authors.forename: Verinder
authors.initials: V
authors.lastname: Sharma
authors.forename: Angela
authors.initials: A
authors.lastname: Smith
authors.forename: Dwight
authors.initials: D
authors.lastname: Mazmanian
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000150:complications; D005260:Female; D006801:Humans; D000077152:Olanzapine; D011618:Psychotic Disorders / Q000209:etiology / Q000517:prevention & control*; D011644:Puerperal Disorders / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine