title: Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake.
abstract: Many health benefits are associated with a high dietary intake of vegetables and fruit (VF); however, little effort has been expended to determine whether the botanical families from which high-VF diets are formulated affect their biological activities. The objective of this study was to determine whether the botanical diversity of high-VF diets alters the response in oxidative biomarkers for lipid peroxidation and DNA oxidation. Two diets were developed that varied in botanical diversity and provided 8-10 servings of VF/d. The high botanical diversity diet (HBD) included foods from the 18 botanical families that induced a reduction in oxidative damage of lipids or DNA. The low botanical diversity diet (LBD) emphasized 5 of these botanical families based on reports that their bioactive components had high antioxidant activity. A total of 106 women completed the study. Participants consumed 9.1 +/- 2.6 and 8.3 +/- 2.1 servings of VF/d with the LBD and HBD diets. Only the HBD diet induced a significant reduction in DNA oxidation (P < 0.05). Both the LBD and the HBD diets were associated with a reduction in lipid peroxidation (P < 0.01). These findings indicate that botanical diversity plays a role in determining the bioactivity of high-VF diets and that smaller amounts of many phytochemicals may have greater beneficial effects than larger amounts of fewer phytochemicals.
authors.affiliation: Colorado State University, Fort Collins, CO 80523, USA. henry.thompson@colostate.edu
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Thompson
authors.forename: Jerianne
authors.initials: J
authors.lastname: Heimendinger
authors.forename: Ann
authors.initials: A
authors.lastname: Diker
authors.forename: Caitlin
authors.initials: C
authors.lastname: O'Neill
authors.forename: Al
authors.initials: A
authors.lastname: Haegele
authors.forename: Becky
authors.initials: B
authors.lastname: Meinecke
authors.forename: Pamela
authors.initials: P
authors.lastname: Wolfe
authors.forename: Scot
authors.initials: S
authors.lastname: Sedlacek
authors.forename: Zongjian
authors.initials: Z
authors.lastname: Zhu
authors.forename: Weiqin
authors.initials: W
authors.lastname: Jiang
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000652:urine; D002338:Carotenoids / Q000097:blood; D004032:Diet; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005638:Fruit / Q000145:classification*; D006801:Humans; D015227:Lipid Peroxidation; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D014662:Vasoconstrictor Agents / Q000097:blood; D014675:Vegetables / Q000145:classification*
chemical_list: D015415:Biomarkers; D014662:Vasoconstrictor Agents; C075750:8-epi-prostaglandin F2alpha; D002338:Carotenoids; D015237:Dinoprost