Synthesis, spectroscopic characterization and biological analysis of a new palladium(II) complex with methionine sulfoxide.
A new palladium(II) complex with methionine sulfoxide was synthesized and characterized by a set of chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pd(C5H10NO3S)2].H2O. 13C NMR, [1H-15N] NMR and infrared spectra indicate coordination of the amino acid to Pd(II) through the carboxylate and amino groups in a square planar geometry. The complex is soluble in water. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium salt colorimetric assay, which reflects the cells viability. After incubation for 48 h, 20% of cell death was achieved at a concentration of 200 micromol L-1 of the complex.
Corbi
Pedro P
PP
Departamento de Química Geral e Inorgânica, Instituto de Química, UNESP, Rua Prof. Francisco Degni s/n, CP 355, CEP 14801-970 Araraquara, SP, Brazil. pedrocorbi@yahoo.com
Cagnin
Flávia
F
Sabeh
Lilian P B
LP
Massabni
Antonio C
AC
Costa-Neto
Claudio M
CM
D016923:Cell Death / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008715:Methionine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D010165:Palladium; D008715:Methionine; C013111:methionine sulfoxide