title: Analysis of nandrolone esters in oily injections by reversed-phase high-performance liquid chromatography.
abstract: A specific liquid chromatographic (HPLC) procedure is presented for the analysis of nandrolone esters (phenylpropionate, decanoate and undecanoate) in commercial oily injections. The analysis was carried out under isocratic, reversed-phase (RP8 column) conditions using a UV detector (240 nm). The system discriminates between nandrolone alcohol, a potential impurity, and its esters and permits the quantitation of trace benzaldehyde derived from the oxidative degradation of benzyl alcohol. The proposed HPLC method was found to be more specific and accurate than the pharmacopoeial spectrophotometric assay procedure (isoniazid reagent). The interference of benzaldehyde with the isoniazid method was also investigated.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, via Belmeloro 6, 40126 Bologna, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Cavrini
authors.forename: A M
authors.initials: AM
authors.lastname: Di Pietra
authors.forename: M A
authors.initials: MA
authors.lastname: Raggi
authors.forename: R
authors.initials: R
authors.lastname: Sarti