[The influence of antileukotrienes on the skin reactivity induced by histamine and allergens by visual evaluation and laser Doppler flowmetry].
There is different opinion whether antileukotrienes can influence skin prick tests (SPT) results.


OBJECTIVE
Estimation of SPT results with laser Doppler flowmetry (LDF) for histamine solutions and allergens before and after usage of antileukotrienes.


METHODS
The study group consisted of 27 patients with allergic diseases. Before and after 4 days of zafirlukast or placebo usage, there were done SPT on the skin of the back with three histamine solutions (0.1 mg/ml, 1.0 mg/ml, 10.0 mg/ml) and with standard inhalant allergens. The estimation of SPT was done visually and with use of LDF. The cutaneous blood flow was measured after 15 minutes using Periflux PF 3 (PERIMED, Sweden) in point 5 mm of distance from prick center.


RESULTS
Both visual estimations and flow rate didn't show the statistical differences between SPT with histamine solutions and allergens before and after 4 days use of antileukotrienes.


CONCLUSIONS
Zafirlukast usage in dose 20 mg twice daily for 4 days does not influence on immediate skin reactivity on histamine solutions or allergens in visual evaluations as well laser Doppler flowmetry. There is no need of zafirlukast discontinuation before skin prick tests.
Zakrzewski
Aleksander
A
Wojskowy Instytut Medyczny w Warszawie, Klinika Chorób Infekcyjnych i Alergologii, CSK MON. olozak@wp.pl
Kruszewski
Jerzy
J
Kłos
Krzysztof
K
D000328:Adult; D000485:Allergens; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006632:Histamine; D006801:Humans; D007211:Indoles; D017078:Laser-Doppler Flowmetry; D020024:Leukotriene Antagonists / Q000494:pharmacology*; D008297:Male; D048448:Phenylcarbamates; D012867:Skin / Q000098:blood supply*; D012882:Skin Tests; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000494:pharmacology*
D000485:Allergens; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds; D006632:Histamine; C062735:zafirlukast