Deregulated NF-kappaB activity in haematological malignancies.
The NF-kappaB family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappaB activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappaB deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor.
Keutgens
Aurore
A
Laboratory of Medical Chemistry, Center for Cellular and Molecular Therapy, Center for Biomedical Integrative Genoproteomics, University of Liege, Tour de Pathologie, +3 B23, CHU Sart-Tilman, 4000 Liège, Belgium.
Robert
Isabelle
I
Viatour
Patrick
P
Chariot
Alain
A
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D049109:Cell Proliferation; D005786:Gene Expression Regulation / Q000502:physiology; D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism* / Q000502:physiology
D016328:NF-kappa B