title: Antibiotic-polymethylmethacrylate strut: an option for treating cervical pyogenic spondylitis. Case report.
abstract: Antibiotic-polymethylmethacrylate (PMMA) cement and beads constitute an effective system of local drug delivery of antibiotic agents in patients with bone and soft-tissue infections. Debridement followed by implantation of antibiotic-PMMA beads and systemic administration of antibiotic agents has achieved a 100% success rate in treating chronic osteomyelitis; however, there have been no reports of an antibiotic-PMMA strut for treating spinal pyogenic spondylitis. In this case report we describe a 57-year-old woman with C5-6 pyogenic spondylitis, progressive kyphotic deformity, and neurological deficits. The patient underwent anterior C-5 and C-6 corpectomy and spinal reconstruction in which we used an antibiotic-PMMA strut. The strut was 14 mm in diameter and contained PMMA and vancomycin powder. The operation was technically successful, and no complication related to anesthesia or the surgical procedure occurred. At the 12-month follow-up examination, dynamic radiographs revealed cervical spine stabilization. The patient's neck pain subsided and she recovered neurologically with no residual infection. No antibiotic-PMMA strut dislodgment or failure was identified; however, 9.8% subsidence of the strut into the vertebrae was observed. The long-term outcome in this case requires further evaluation.
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan, Republic of China. chenjf@adm.cgmh.org.tw
authors.forename: Jyi-Feng
authors.initials: JF
authors.lastname: Chen
authors.forename: Shih-Tseng
authors.initials: ST
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002574:Cervical Vertebrae; D005260:Female; D006801:Humans; D008875:Middle Aged; D019904:Polymethyl Methacrylate; D013123:Spinal Fusion / Q000295:instrumentation; D013166:Spondylitis / Q000382:microbiology / Q000628:therapy*; D013203:Staphylococcal Infections / Q000628:therapy*; D014640:Vancomycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D019904:Polymethyl Methacrylate