title: Mesangial proliferative glomerulonephritis after autologous stem cell transplantation.
abstract: Although glomerulonephritis and renal failure have been observed after allogenic stem cell transplantation, only a few such reports were published about patients undergoing autologous stem cell transplantation. We report a case of mesangial proliferative glomerulonephritis developing 4 months after autologous stem cell transplantation for chronic lymphatic leukemia. Serological test results, together with histological, immunohistochemical, and electronic microscopic findings of a kidney biopsy specimen, confirmed the diagnosis of mesangial proliferative glomerulonephritis in our patient. Complement and immunoglobulin A were not present in the kidney biopsy specimen. An abnormal clone, not previously reported, with the translocation t(5;11)(q31;q13) in blood and bone marrow was observed. The reason for and whether progenitor cells in stem cell transplantations could contribute to the development of glomerulonephritis remain open questions. Kidney biopsy should be performed in patients with microscopic hematuria and/or proteinuria after autologous stem cell transplantation.
authors.affiliation: Department of Medicine, Division of Nephrology, Central Hospital, Central Finland Health Care District, Jyväskylä. terje.forslund@ksshp.fi
authors.forename: Terje
authors.initials: T
authors.lastname: Forslund
authors.forename: Jorma
authors.initials: J
authors.lastname: Anttinen
authors.forename: Heikki
authors.initials: H
authors.lastname: Hallman
authors.forename: Kristiina
authors.initials: K
authors.lastname: Heinonen
authors.forename: Reino
authors.initials: R
authors.lastname: Pitkänen
mesh_terms: D001706:Biopsy; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy; D050527:Mesangial Cells; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D013997:Time Factors; D014182:Transplantation, Autologous