Clinician validation of Poison Control Center (PCC) intentional exposure cases involving prescription opioids.
Poison Control Center (PCC) cases involving intentional ingestion, injection or inhalation of prescription opioids are a potentially valuable source of information on the abuse and misuse of these products. This study sought to validate PCC classifications of prescription opioid intentional exposure cases against clinical diagnostic criteria. 4,321 cases were reviewed. PCC-clinician concordance was good to excellent for Withdrawal, Abuse, and Suicide (kappa statistics: 0.73, 0.53, 0.48, respectively), but poor for Misuse and Intentional Unknown (Specific motive not known). Interrater reliability among clinicians was good (weighted kappa range: 0.56-0.68). Results demonstrate the degree of compatibility between PCC and standard nosologic classifications.
Smith
Meredith Y
MY
Purdue Pharma L.P., Stamford, Connecticut 06901-3431, USA. meredith.smith@pharma.com
Dart
Richard
R
Hughes
Alice
A
Geller
Anne
A
Senay
Edward
E
Woody
George
G
Colucci
Salvatore
S
D004353:Drug Evaluation, Preclinical; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D006801:Humans; D033182:Intention; D009294:Narcotics / Q000009:adverse effects; D015588:Observer Variation; D011039:Poison Control Centers / Q000706:statistics & numerical data*; D013375:Substance Withdrawal Syndrome / Q000453:epidemiology / Q000209:etiology; D019966:Substance-Related Disorders / Q000453:epidemiology*; D013405:Suicide / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires
D009294:Narcotics