cGMP signalling in a transporting epithelium.
The biochemical aspects of cGMP signalling are well known, although in vivo roles of cGMP have only been recently discovered through work in genetic model organisms. The Drosophila melanogaster Malpighian (renal) tubule has been used to address the roles of cGMP in epithelial function. Here, we describe some of this work and outline recent progress in understanding the organotypic function of novel phosphodiesterases encoded by the D. melanogaster genome.
Davies
S-A
SA
Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Dumbarton Road, Glasgow G116NU, UK. s.a.davies@bio.gla.ac.uk
Day
J P
JP
D000818:Animals; D001692:Biological Transport; D006152:Cyclic GMP / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D008317:Malpighian Tubules / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D015398:Signal Transduction
D010727:Phosphoric Diester Hydrolases; D006152:Cyclic GMP