title: Proteasome inhibition and Parkinson's disease modeling.
abstract: Impaired proteasome function is a potential mechanism for dopaminergic neuron degeneration. To model this molecular defect, we administered systemically the reversible lipophilic proteasome inhibitor, carbobenzoxy-L-isoleucyl-gamma-t-butyl-L-glutamyl-L-alanyl-L-leucinal (PSI), to rodents. In contrast to a previous report, this approach failed to cause any detectable behavioral or neuropathological abnormality in either rats or mice. Although theoretically appealing, this specific model of Parkinson's disease appears to exhibit poor reproducibility.
authors.affiliation: Department of Neurology, Columbia University, New York, NY, USA.
authors.forename: Jordi
authors.initials: J
authors.lastname: Bové
authors.forename: Chun
authors.initials: C
authors.lastname: Zhou
authors.forename: Vernice
authors.initials: V
authors.lastname: Jackson-Lewis
authors.forename: Julie
authors.initials: J
authors.lastname: Taylor
authors.forename: Yaping
authors.initials: Y
authors.lastname: Chu
authors.forename: Hardy J
authors.initials: HJ
authors.lastname: Rideout
authors.forename: Du-Chu
authors.initials: DC
authors.lastname: Wu
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Kordower
authors.forename: Leonard
authors.initials: L
authors.lastname: Petrucelli
authors.forename: Serge
authors.initials: S
authors.lastname: Przedborski
mesh_terms: D000818:Animals; D002460:Cell Line; D015853:Cysteine Proteinase Inhibitors / Q000633:toxicity*; D004195:Disease Models, Animal; D005434:Flow Cytometry; D049452:Green Fluorescent Proteins / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009842:Oligopeptides / Q000633:toxicity*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D015853:Cysteine Proteinase Inhibitors; D009842:Oligopeptides; C090535:benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal; D049452:Green Fluorescent Proteins; D014446:Tyrosine 3-Monooxygenase