[Phenomenon of ischemic preconditioning and myocardial reserve in patients after myocardial infarction].
In order to assess effect of ischemic preconditioning (IP) on the level of myocardial reserve in patients after myocardial infarction we divided 78 patients into 2 groups -- with and without IP. It was shown that presence of IP in postinfarction period was associated with better parameters of systolic and diastolic left ventricular function: patients with IP had 1.15, 1.14 and 1.47 times lower end-systolic, end-diastolic volumes and myocardial mass index, respectively, and 1.38 times higher ejection fraction. The study of central hemodynamics during exercise on velo-ergometer revealed in these patients significantly smaller lowering of cardiac output in preischemic period and more rapid recovery during first 5 minutes of rest. All this was accompanied with almost twofold decrease of number of patients with clinical signs of heart failure. A conclusion has been made that in post myocardial infarction patients IP not only favorably affects level of coronary reserve but promotes maintenance of systolic and diastolic function of left ventricular myocardium at higher level.
D000328:Adult; D000368:Aged; D015716:Electrocardiography, Ambulatory; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D009203:Myocardial Infarction / Q000503:physiopathology / Q000534:rehabilitation*; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000502:physiology*