Endoscopic scoring of late gastrointestinal mucosal damage after adjuvant radiochemotherapy.
OBJECTIVE
To evaluate late effects of chemoradiation on gastrointestinal mucosa with an endoscopic scoring system and compare it to a clinical scoring system.


METHODS
Twenty-four patients going to receive chemoradiation after gastric surgery underwent endoscopy four wk after surgery and one year after the chemoradiation finished. Upper gastrointestinal findings were recorded according to a system proposed by World Organisation for Digestive Endoscopy (OMED) and clinical scoring was done with RTOG-EORTC radiation morbidity scoring systems.


RESULTS
There was no significant endoscopic difference in gastric and intestinal mucosa after chemoradiation (P > 0.05) and there was no association between endoscopic scores and clinical scores. Endoscopic changes were minimal.


CONCLUSIONS
Late effects after chemoradiation in operated patients with gastric cancers can be evaluated with an endoscopic scoring system objectively and this system is superior to clinical scoring systems.
Dabak
Resat
R
Department of Family Medicine, Kartal State Hospital, Kartal, Istanbul, Turkey.
Uygur-Bayramicli
Oya
O
Gemici
Cengiz
C
Yavuzer
Dilek
D
Sargin
Mehmet
M
Yildirim
Mehmet
M
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003131:Combined Modality Therapy; D016099:Endoscopy, Gastrointestinal / Q000706:statistics & numerical data*; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D006801:Humans; D015601:Injury Severity Score; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000145:classification; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy