Triterpenoids from the husks of Xanthoceras sorbifolia Bunge.
A new triterpenoid saponin, 3-O-[(3-O-alpha-l-arabinofuranosyl-2-O-beta-d-galactopyranosyl)-beta-d-glucuronopyranosyl]-21,22-di-O-angeloyl-R1-barrigenol (1), together with four known triterpenoids, have been isolated from the husks of Xanthoceras sorbifolia Bunge. Their structures were elucidated based on chemical and spectral analysis. Among them, 1 was found to have activity of inhibiting the proliferation of six human tumour cell lines (IC50 10-40 mug/ml).
Li
Z-L
ZL
Shenyang Pharmaceutical University, Research Department of Natural Medicine, Shenyang, 110016, China.
Yang
B-Z
BZ
Li
X
X
Wang
S-J
SJ
Li
N
N
Wang
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D029631:Sapindaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C517450:3-O-((3-O-alpha-l-arabinofuranosyl-2-O-beta-d-galactopyranosyl)-beta-d-glucuronopyranosyl)-21,22-di-O-angeloyl-R1-barrigenol; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes