The analytical control of the composition of creams.
The analysis without prior sample clean-up of promethazine hydrochloride or clioquinol in commercially available creams has been investigated using UV-spectrophotometry and titrimetric methods. The results were compared with those obtained by GLC and HPLC. Although in some cases the active drug could be determined satisfactorily using the comparatively non-selective UV-absorbance or titrimetric methods, these methods were found to be reliable only when applied to creams for which the qualitative and quantitative composition was completely known. Without prior sample clean-up, these methods will therefore be of interest mainly for process control purposes in manufacturing.
van de Vaart
F J
FJ
Laboratory of the Dutch Pharmacists, Alexanderstraat 11, 2514 JL The Hague, The Netherlands.
Hulshoff
A
A
Indemans
A W
AW