Cell polarity: formin on the move.
Formins assemble actin filaments that are typically arranged in long bundles. A new study has discovered that a fission yeast polarity formin transiently assembles short actin filaments at the cell tip, and then releases from the cortex and rides into the cell interior on filaments within the bundle.
Kovar
David R
DR
Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA. drkovar@uchicago.edu
D008841:Actin Cytoskeleton / Q000378:metabolism / Q000502:physiology; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D016764:Cell Polarity; D000080865:Formins; D051379:Mice; D008840:Microfilament Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D012568:Schizosaccharomyces / Q000166:cytology* / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; C491464:Diap1 protein, mouse; C444419:FOR3 protein, S pombe; D000080865:Formins; D008840:Microfilament Proteins; D029702:Schizosaccharomyces pombe Proteins