First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America.
The plasmid-mediated class A carbapenemase KPC-2 was isolated from unrelated Klebsiella pneumoniae isolates in Medellin, Colombia. These KPC enzymes are the first from South America and the second isolation outside of the United States. The expanding geographic spread of KPC carbapenemases underscores the importance of clinical recognition of these enzymes.
Villegas
Maria Virginia
MV
CIDEIM (International Center for Medical Research and Training), Cali, Colombia.
Lolans
Karen
K
Correa
Adriana
A
Suarez
Carlos Jose
CJ
Lopez
Jaime A
JA
Vallejo
Marta
M
Quinn
John P
JP
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D015780:Carbapenems / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D007526:Isoelectric Point; D007710:Klebsiella Infections / Q000453:epidemiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010957:Plasmids / Q000235:genetics*; D013020:South America / Q000453:epidemiology; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; C063912:carbapenemase