Direct access to enantiomerically enriched alpha-amino phosphonic acid derivatives by organocatalytic asymmetric hydrophosphonylation of imines.
A simple and efficient organocatalytic enantioselective hydrophosphonylation of imines to enantiomerically enriched alpha-amino phosphonates is reported. By using 10 mol % of quinine as the catalyst in the enantioselective addition of diethyl phosphite to N-Boc protected imines, alpha-amino phosphonates are obtained in moderate to good yields and with up to 94% ee.
Pettersen
Daniel
D
Department of Organic Chemistry "A. Mangini", University of Bologna, V. Risorgimento 4, 40136 Bologna, Italy. dap@chem.gu.se
Marcolini
Mauro
M
Bernardi
Luca
L
Fini
Francesco
F
Herrera
Raquel P
RP
Sgarzani
Valentina
V
Ricci
Alfredo
A