title: Hyperinols A and B, chymotrypsin inhibiting triterpenes from Hypericum oblongifolium.
abstract: Hyperinols A (1) and B (2) are new taraxastane type triterpenes which have been isolated from the chloroform soluble fraction of Hypericum oblongifolium and their structures elucidated on the basis of spectroscopic data. Both showed significant inhibitory activity against chymotrypsin enzyme.
authors.affiliation: Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex, Karachi-75280, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Ferheen
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmed
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
authors.forename: Muhammad Arif
authors.initials: MA
authors.lastname: Lodhi
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D002725:Chloroform / Q000737:chemistry; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C513990:3,22-dihydroxy-20(30)-taraxastane-28,13-olide; C513989:3-hydroxy-20(30)-taraxastene-28,13-olide; D012996:Solutions; D014315:Triterpenes; D014361:Trypsin Inhibitors; D002725:Chloroform; D002918:Chymotrypsin