Microcalorimetric and chromatographic investigations of the binding of some pyridine derivatives to cyclodextrins.
The binding of some pyridine derivatives to alpha-, beta- and gamma-cyclodextrins has been investigated by microcalorimetry. The strongest binding is to beta-cyclodextrin, but the binding constants are of the order 10(2) M(-1). The binding to beta-cyclodextrin was also investigated by high performance liquid chromatography. The addition of beta-cyclodextrin to the mobile phase allowed separation of molecules with similar binding constants and of racemates in the case of tropicamide.
El Gezawi
S
S
Department of Pharmacy University of Assiut, Assiut, Egypt.
Omar
N
N
El Rabbat
N
N
Ueda
H
H
Perrin
J H
JH