FOXP3 and NFAT: partners in tolerance.
Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.
Rudensky
Alexander Y
AY
Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA. aruden@u.washington.edu
Gavin
Marc
M
Zheng
Ye
Y
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D015551:Autoimmunity; D001483:Base Sequence; D015415:Biomarkers / Q000378:metabolism; D051927:CD24 Antigen / Q000276:immunology; D018360:Crystallography, X-Ray; D051858:Forkhead Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology; D017930:Genes, Reporter; D006801:Humans; D006860:Hydrogen Bonding; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology; D019169:Jurkat Cells; D008156:Luciferases / Q000378:metabolism; D008213:Lymphocyte Activation; D008954:Models, Biological; D008969:Molecular Sequence Data; D050778:NFATC Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D017434:Protein Structure, Tertiary; D015375:Receptors, Interleukin-2 / Q000276:immunology; D017386:Sequence Homology, Amino Acid; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D015415:Biomarkers; D051927:CD24 Antigen; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D007376:Interleukin-2; D050778:NFATC Transcription Factors; D015375:Receptors, Interleukin-2; D008156:Luciferases