title: Edrophonium provocative testing for the evaluation of upper gastrointestinal hypersensitivity in patients with nonulcer dyspepsia.
abstract: The aim of this study was to examine if edrophonium provocative testing is useful for evaluating upper gastrointestinal hypersensitivity in patients with nonulcer dyspepsia (NUD). A questionnaire rating dyspeptic symptoms was done for 58 patients with NUD. The patients were then given an intravenous infusion of saline followed by 5 mg of edrophonium. Baseline esophageal manometry was also done. Patients whose usual symptoms were reproduced (48.3%) had significantly higher symptom scores (13.0 [8.5, 17.0] vs. 8.5 [6.0, 11.0]; P = 0.015) and a significantly higher number of symptoms (4.0 [2.5, 6.0] vs. 3.0 [1.0, 4.0]; P = 0.010) than patients whose usual symptoms were not reproduced. The presence of an esophageal motility disorder was not significantly different between the two groups. These findings suggest upper gastrointestinal hypersensitivity in the patients whose symptoms were reproduced. Edrophonium provocative testing might be useful for evaluating upper gastrointestinal hypersensitivity in patients with NUD.
authors.affiliation: Department of Psychosomatic Medicine, Graduate School of Medicine, Kyushu University, Fukuoka, 812-8582, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tsutsui
authors.forename: Kazunori
authors.initials: K
authors.lastname: Mine
authors.forename: Masanori
authors.initials: M
authors.lastname: Handa
authors.forename: Haruo
authors.initials: H
authors.lastname: Hayashi
authors.forename: Masako
authors.initials: M
authors.lastname: Hosoi
authors.forename: Naoko
authors.initials: N
authors.lastname: Kinukawa
authors.forename: Chiharu
authors.initials: C
authors.lastname: Kubo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage; D004415:Dyspepsia / Q000150:complications* / Q000175:diagnosis; D004491:Edrophonium / Q000008:administration & dosage; D015154:Esophageal Motility Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D007262:Infusions, Intravenous; D008297:Male; D008365:Manometry; D008875:Middle Aged; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
chemical_list: D002800:Cholinesterase Inhibitors; D004491:Edrophonium