Dimerization in protein kinase signaling.
The closely related mitogen-activated protein kinases ERK1 and ERK2 have now been shown to have opposing roles in Ras-mediated cell proliferation. I propose that dimerization of these highly related protein kinases could underlie these surprising observations and that this could be a common paradigm for widespread regulation of protein phosphorylation by kinase-substrate interactions.
Pelech
Steven
S
The Brain Research Centre, Division of Neurology, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 2B5, Canada. spelech@kinexus.ca
D000818:Animals; D019281:Dimerization; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity
D011494:Protein Kinases