title: [Occurrence of plasmic and platelet prothrombotic polymorphisms in women in childbirth].
abstract: METHODS
  Plasmic pro-thrombotic factors as well as pro-thrombotic platelet glycoprotein mutations have been shown to play an important role in the mechanism of the thrombo-embolic disease. However, there is no published study evaluating the role of above mentioned genetic factors in the thrombo-embolic episodes in women in childbirth.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the role of selected genetic factors in appearance of thrombo-embolic complications in the women in childbirth, and to determine if there is the coexistence of selected platelet glycoprotein polymorphisms and factor V Leiden mutations.
  
  
  METHODS
  71 cases of women in child birth with thrombo-embolic disease were analyzed. Selected demographic characteristics, and genetic pro-thrombotic factors like factor V Leiden mutation, and pro-thrombotic platelet glycoprotein GP Ia, and GP IIIa polymorphisms were examined.
  
  
  RESULTS
  Amongst pro-thrombotic platelet glycoprotein polymorphisms moderately pro-thrombotic heterozygous A1/A2, and heterozygous C/T were most prevalent. The least common were strongly pro-thrombotic homozygous A2/A2, and T/T. Analysis of the factor V Leiden mutation revealed statistically significant difference in the presence of allele A, which determines the prothrombotic tendencies in its carrier.
  
  
  CONCLUSIONS
  Our study shows that factor V Leiden mutation, and investigated platelet GP Ia, and GP IIIa polymorphisms frequently coexist. Moreover, presence of factor V Leiden mutation is a risk factor for thrombo-embolic disease in the women in childbirth.
authors.affiliation: Klinika Medycyny Matczyno-Płodowej i Ginekologii, Instytutu Centrum Zdrowia Matki Polki w Lodzi. lechpodciech@go2.pl
authors.forename: Lech
authors.initials: L
authors.lastname: Podciechowski
authors.forename: Dorota
authors.initials: D
authors.lastname: Nowakowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Dabrowska
authors.forename: Adam
authors.initials: A
authors.lastname: Bielak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Dziatosz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Krasomski
authors.forename: Jan
authors.initials: J
authors.lastname: Wilczyński
mesh_terms: D000328:Adult; D005165:Factor V / Q000235:genetics; D005167:Factor VII / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D039421:Integrin alpha2 / Q000235:genetics; D039661:Integrin beta3 / Q000235:genetics; D007743:Labor, Obstetric / Q000097:blood*; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology / Q000235:genetics*; D020246:Venous Thrombosis / Q000453:epidemiology / Q000235:genetics*
chemical_list: D039421:Integrin alpha2; D039661:Integrin beta3; D005165:Factor V; D005167:Factor VII