Small-molecule screening made simple for a difficult target with a signaling nucleic acid aptamer that reports on deaminase activity.
Elowe
Nadine H
NH
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
Nutiu
Razvan
R
Allali-Hassani
Abdellah
A
Cechetto
Jonathan D
JD
Hughes
Donald W
DW
Li
Yingfu
Y
Brown
Eric D
ED
D000243:Adenosine Deaminase / Q000737:chemistry; D058892:Adenosine Deaminase Inhibitors; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D001665:Binding Sites; D015374:Biosensing Techniques / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D019793:Fluorescein / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D015394:Molecular Structure
D058892:Adenosine Deaminase Inhibitors; D052157:Aptamers, Nucleotide; D004791:Enzyme Inhibitors; D005456:Fluorescent Dyes; D000243:Adenosine Deaminase; D019793:Fluorescein