Compartmentalized cAMP signalling: a personal perspective.
Scaffolding proteins create order out of chaos. Multifunctional binding proteins such as the AKAPs (A-kinase-anchoring proteins) oversee the dynamic organization of signalling events by clustering activator proteins with kinases, phosphatases and phosphodiesterases and directing them toward their downstream effectors. This article will focus on the role of AKAPs in the spatial and temporal control of cAMP signalling events.
Scott
J D
JD
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, MRB322, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. scott@ohsu.edu
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D000242:Cyclic AMP