title: Subchronic administration of LY354740 does not modify ketamine-evoked behavior and neuronal activity in rats.
abstract: Acute treatment with LY354740 {1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate}, a potent and selective agonist for group II metabotropic glutamate receptors (mGlu2/3), has previously been shown to block some schizophrenia-like effects of N-methyl-D-aspartate (NMDA) receptor antagonists, suggesting a novel therapeutic strategy for schizophrenia. The present study examined the effects of subchronic pretreatment with LY354740 (0.3, 3 and 10 mg/kg i.p.) on ketamine-evoked (12 mg/kg s.c.) prepulse inhibition deficits, hyperlocomotion and c-fos expression. At all doses, LY354740 failed to reverse both behavioral and neuronal effects of the ketamine. These results therefore do not support the putative antipsychotic role of LY354740.
authors.affiliation: Department of Psychiatry, University Medical Center Groningen, P7.16, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen, The Netherlands. g.imre@med.umcg.nl
authors.forename: Gabor
authors.initials: G
authors.lastname: Imre
authors.forename: Dirk S
authors.initials: DS
authors.lastname: Fokkema
authors.forename: Gert J
authors.initials: GJ
authors.lastname: Ter Horst
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007150:Immunohistochemistry; D007649:Ketamine / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D009068:Movement; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D001643:Bridged Bicyclo Compounds; D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine; C104753:eglumetad