A review of nelfinavir for the treatment of HIV infection.
Nelfinavir (NFV) is a protease inhibitor that has been widely used for several years for the treatment of HIV infection. This has led to extensive experience with NFV-containing regimens, in which the drug has shown prolonged viral suppression, good tolerability and a unique resistance profile. In recent years, several antiretroviral drugs with some advantages over NFV have been developed. Nevertheless, NFV has favourable characteristics that make it a suitable antiretroviral compound for many HIV-infected patients. It can be used in patients who do not tolerate ritonavir even at low doses, and it is well tolerated in pregnant women, has a low-grade interaction with methadone and may be well tolerated in hepatitis C virus-co-infected patients. In addition, its new simplified posology may contribute to improved adherence.
Olmo
Montserrat
M
Hospital Universitario de Bellvitge, Infectious Diseases Service, HIV Unit, Hospitalet de Llobregat, Barcelona, Spain. molmo@csub.scs.es
Podzamczer
Daniel
D
D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D015394:Molecular Structure; D019888:Nelfinavir / Q000737:chemistry / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000821:virology; D011480:Protease Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
D011480:Protease Inhibitors; D019888:Nelfinavir