Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity.
Feyen
Fabian
F
ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Hönggerberg, HCI H 405, 8093 Zürich, Switzerland.
Gertsch
Jürg
J
Wartmann
Markus
M
Altmann
Karl-Heinz
KH
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002851:Chromatography, High Pressure Liquid; D034261:Epothilones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008854:Microscopy, Electron
D000970:Antineoplastic Agents; D001688:Biological Products; D034261:Epothilones