title: Cyprinid herpes virus-3 (CyHV-3) bears genes of genetically distant large DNA viruses.
abstract: A large DNA virus, designated koi herpes virus (KHV), carp interstitial nephritis gill necrosis virus (CNGV) and Cyprinid herpes virus-3 (CyHV-3), causes massive mortality of carp. Morphologically, the virus resembles herpes viruses, but it contains a genome of ca 295 kbp, larger than that of any Herpesviridae member. Interestingly, three CyHV-3 genes, thymidylate monophosphate kinase (TmpK), ribonucleotide reductase and thymidine kinase, which are involved in deoxynucleotide tri-phosphate synthesis, resemble those of pox viruses. In addition to the TmpK gene, which is nonexistent in the genome of herpes viruses, CyHV-3 contains a B22R-like gene, exclusively expressed by pox viruses. These results raise questions on the phylogenic origin of CyHV-3.
authors.affiliation: Department of Pathology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Ilouze
authors.forename: Arnon
authors.initials: A
authors.lastname: Dishon
authors.forename: Tamar
authors.initials: T
authors.lastname: Kahan
authors.forename: Moshe
authors.initials: M
authors.lastname: Kotler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002347:Carps / Q000821:virology; D002460:Cell Line; D005814:Genes, Viral; D016679:Genome, Viral; D006564:Herpesviridae / Q000145:classification / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011212:Poxviridae / Q000145:classification / Q000235:genetics; D016415:Sequence Alignment; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins