[Peculiarities of regulation of cardiac function in some mammals].
We studied acetylcholine induced changes of action potentials (AP) in ventricles and atria of bat, hedgehog, yakut ground squirrel, and laboratory mice. In atria of all these species of mammals acetylcholine caused pronounced dose dependent shortening of AP. However sensitivity of ventricles of studied animals to acetylcholine was different. Acetylcholine induced AP shortening was 29.4, 42.1, 6.6 and 11% in ventricles of bat, hedgehog, laboratory mice and ground squirrel, respectively. Ventricles of none of previously studied mammals had sensitivity to acetylcholine comparable by magnitude to acetylcholine sensitivity which we found in hedgehog and bat. It is suggested that these animals have unique nervous regulation of cardiac action, principally different from that of other mammals, which do not require parasympathetic regulation of ventricles.
Abramochkin
A V
AV
Sukhova
G S
GS
Rozenshtraukh
L V
LV
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002685:Chiroptera; D005260:Female; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D006329:Heart Conduction System / Q000187:drug effects / Q000502:physiology; D006352:Heart Ventricles / Q000187:drug effects; D006364:Hedgehogs; D008297:Male; D051379:Mice; D012589:Sciuridae; D014665:Vasodilator Agents / Q000494:pharmacology; D016276:Ventricular Function
D014665:Vasodilator Agents; D000109:Acetylcholine