title: Telomere shortening with aging in the human pancreas.
abstract: We have conducted systematic studies to measure telomere length in human tissues of all types. Progressive telomere shortening with aging was studied in specimens of normal pancreas obtained at autopsy from 69 subjects aged 0 to 100 yr, and age-related shortening of telomere length at a rate of 36 base pairs (bp) per year was detected. Mean telomere length (+/-SD) was 13.9+/-1.4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/-SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5+/-1.5, 12.3+/-0.7, 11.3+/-2.5, and 10.7+/-1.8, respectively.
authors.affiliation: Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. aishii@tmig.or.jp
authors.forename: Akio
authors.initials: A
authors.lastname: Ishii
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kishimoto
authors.forename: Naoko
authors.initials: N
authors.lastname: Honma
authors.forename: Junko
authors.initials: J
authors.lastname: Aida
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.forename: Mutsunori
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Fujio
authors.initials: F
authors.lastname: Takeuchi
authors.forename: Motonobu
authors.initials: M
authors.lastname: Kato
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Oshimura
authors.forename: Naotaka
authors.initials: N
authors.lastname: Izumiyama
authors.forename: Kaiyo
authors.initials: K
authors.lastname: Takubo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D008136:Longevity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D016615:Telomere / Q000235:genetics*
chemical_list: D004247:DNA