[Clinical significance of serum-glycated apolipoprotein B measured by the digestion LDL sediment fraction with protease].
We previously reported an assay method for serum glycated aplipoprotein B (G-apo B) using protease. The present study demonstrated correlations between serum G-apo B levels and some other serum parameters, from which a clinical significance of the G-apo B in diabetics was deduced. Serum G-apo B determined by the present method was significantly correlated with glyco-albumin and glycohemoglobin. However, no significant difference was observed between G-apo B levels and total cholesterol and the other lipid items. The mean levels of serum G-apo B in type 2 diabetics with or without hyperlipidemia were significantly higher than in normal subjects (p<0.001). In a comparison of type 2 diabetics with and without hyperlipidemia, the G-apo B levels were not significant between the former and the latter. However, those levels were significantly higher in the nodular and disrupted type of LDL than in the symmetry type of LDL. Even more, the G-apo B levels in the nodular type of LDL were significantly higher than in the disrupted type of LDL. Therefore, the G-apo B levels might be considered an independent risk marker of diabetes hyperlipidemia and atherogenesis.
Shishino
Koji
K
Central Laboratory Department, Ehime University School of Medicine, Toon.
Ochi
Masaaki
M
Murase
Mitsuharu
M
Osawa
Haruhiko
H
Makino
Hideichi
H
D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000494:pharmacology; D012709:Serum Albumin / Q000032:analysis; D000093423:Glycated Serum Albumin; D000093844:Glycated Proteins
D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D008077:Lipoproteins, LDL; D010447:Peptide Hydrolases; D012709:Serum Albumin; D000093423:Glycated Serum Albumin; C031797:glycated lipoproteins, LDL; D000093844:Glycated Proteins