Distal phalange necrosis: a severe manifestation of palmar plantar erythrodysesthesia.
Palmar plantar erythrodysesthesia is a cutaneous drug reaction induced by chemotherapy. We present a case of a patient with neurosensorial deficit affected by ovarian cancer who experienced a painless necrosis of a distal phalange of the hand during treatment with pegylated liposomal doxorubicin. Palmar plantar erythrodysesthesia may be underestimated by physicians in paucisymptomatic patients.
Palaia
Innocenza
I
Department of Obstetrics and Gynecology, La Sapienza University, Rome, Italy.
Angioli
Roberto
R
Bellati
Filippo
F
Basile
Stefano
S
Rabitti
Carla
C
Panici
Pierluigi Benedetti
PB
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D050278:Finger Phalanges / Q000473:pathology*; D006801:Humans; D008081:Liposomes; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010292:Paresthesia / Q000139:chemically induced*; D011092:Polyethylene Glycols
D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D011092:Polyethylene Glycols; D004317:Doxorubicin