title: Temporal subtraction of dual-energy chest radiographs.
abstract: Temporal subtraction and dual-energy imaging are two enhanced radiography techniques that are receiving increased attention in chest radiography. Temporal subtraction is an image processing technique that facilitates the visualization of pathologic change across serial chest radiographic images acquired from the same patient; dual-energy imaging exploits the differential relative attenuation of x-ray photons exhibited by soft-tissue and bony structures at different x-ray energies to generate a pair of images that accentuate those structures. Although temporal subtraction images provide a powerful mechanism for enhancing visualization of subtle change, misregistration artifacts in these images can mimic or obscure abnormalities. The purpose of this study was to evaluate whether dual-energy imaging could improve the quality of temporal subtraction images. Temporal subtraction images were generated from 100 pairs of temporally sequential standard radiographic chest images and from the corresponding 100 pairs of dual-energy, soft-tissue radiographic images. The registration accuracy demonstrated in the resulting temporal subtraction images was evaluated subjectively by two radiologists. The registration accuracy of the soft-tissue-based temporal subtraction images was rated superior to that of the conventional temporal subtraction images. Registration accuracy also was evaluated objectively through an automated method, which achieved an area-under-the-ROC-curve value of 0.92 in the distinction between temporal subtraction images that demonstrated clinically acceptable and clinically unacceptable registration accuracy. By combining dual-energy soft-tissue images with temporal subtraction, misregistration artifacts can be reduced and superior image quality can be obtained.
authors.affiliation: Department of Radiology, The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA. s-armato@uchicago.edu
authors.forename: Samuel G
authors.initials: SG
authors.lastname: Armato
authors.forename: Devang J
authors.initials: DJ
authors.lastname: Doshi
authors.forename: Roger
authors.initials: R
authors.lastname: Engelmann
authors.forename: Philip
authors.initials: P
authors.lastname: Caligiuri
authors.forename: Heber
authors.initials: H
authors.lastname: MacMahon
mesh_terms: D001331:Automation; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D019992:Databases as Topic; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D008400:Mass Chest X-Ray / Q000379:methods*; D017785:Photons; D012372:ROC Curve; D011856:Radiographic Image Enhancement / Q000379:methods*; D015900:Radiography, Dual-Energy Scanned Projection / Q000379:methods*; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D013382:Subtraction Technique