title: Dissociation constants and assay of weak bases in non-aqueous solvents.
abstract: A method is described for evaluating standard cell potentials of specific electrode pair systems in anhydrous acetic acid and acetonitrile. The dissociation constants (K(HB+)) in acetonitrile and the overall dissociation constants (K(B)) and (K(BHClO4)) in anhydrous acetic acid of a series of bases of pharmaceutical interest have been determined. Simple potentiometric and visual titration methods are proposed for the assay of bases and their mixtures.
authors.affiliation: Department of Analytical Chemistry, University of Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Barbosa
authors.forename: D
authors.initials: D
authors.lastname: Barron
authors.forename: J E
authors.initials: JE
authors.lastname: Beneyto
authors.forename: V
authors.initials: V
authors.lastname: Sanz-Nebot