[Pigment deposit in liver of BALB/c mice infected by Schistosoma japonicum and its relation to the effect of praziquantel treatment].
Pigment is a kind of metabolite excreted by schistosome after erythrocyte ingestion. It deposited first in liver sinusoid, then outside and inside of granuloma, and around eggs. The level of pigment was in parallel with the degree of liver fibrosis (P < 0.01). After chemotherapy with praziquantel, the level of pigment decreased considerably (P < 0.01) and the size of granuloma shrinks obviously too (P < 0.01). Therefore, the degree of liver fibrosis in mice with schistosome infection and the effect of praziquantel can be recognized by the level and distribution of pigment.
Tao
Jun
J
Examination laboratory, Hangzhou Army Sanitarium, Hangzhou 310007, China.
Cai
Wei-min
WM
Zhang
Bin-bin
BB
Huang
Yan
Y
Xiang
Quan
Q
Liu
Rong-hua
RH
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use; D003580:Cytochromes / Q000378:metabolism; D005260:Female; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000469:parasitology; D006790:Host-Parasite Interactions; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010270:Parasite Egg Count; D010860:Pigments, Biological / Q000378:metabolism*; D011223:Praziquantel / Q000494:pharmacology* / Q000627:therapeutic use; D012549:Schistosoma japonicum / Q000187:drug effects* / Q000502:physiology; D012554:Schistosomiasis japonica / Q000188:drug therapy* / Q000378:metabolism / Q000469:parasitology
D000871:Anthelmintics; D003580:Cytochromes; D010860:Pigments, Biological; D011223:Praziquantel