The role of serum endothelin-1 level in the etiopathogenesis of central serous chorioretinopathy.
OBJECTIVE
To assess the role of serum endothelin-1 (ET-1) in the pathogenesis of central serous chorioretinopathy (CSC).


METHODS
Prospective, case control study.


METHODS
The serum ET-1 levels of 21 otherwise healthy patients who received a diagnosis of acute CSC (group 1) were measured with the enzyme-linked immunosorbent assay (ELISA) method at the initial visit, at the one month follow-up examination, and after complete angiographic resolution of the leakage. Nine patients with a previous diagnosis of CSC (group 2), 10 patients from the outpatient clinic (group 3), and 14 hospital employees (group 4) were also included.


RESULTS
The serum ET-1 levels in group 1 revealed neither correlation with the disease activity nor significant difference from the levels in groups 2 and 4. However, serum ET-1 levels in group 3 were statistically higher than the levels in groups 1 and 4.


CONCLUSIONS
These findings suggest no role of serum ET-1 in pathogenesis of CSC in otherwise healthy subjects.
Türkçüoğlu
Peykan
P
Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey. peykan74@yahoo.com
Kadayifçilar
Sibel
S
Eldem
Bora
B
D000208:Acute Disease; D016022:Case-Control Studies; D015862:Choroid Diseases / Q000097:blood / Q000209:etiology*; D019332:Endothelin-1 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D011446:Prospective Studies; D012164:Retinal Diseases / Q000097:blood / Q000209:etiology*
D019332:Endothelin-1