title: Distal phalange necrosis: a severe manifestation of palmar plantar erythrodysesthesia.
abstract: Palmar plantar erythrodysesthesia is a cutaneous drug reaction induced by chemotherapy. We present a case of a patient with neurosensorial deficit affected by ovarian cancer who experienced a painless necrosis of a distal phalange of the hand during treatment with pegylated liposomal doxorubicin. Palmar plantar erythrodysesthesia may be underestimated by physicians in paucisymptomatic patients.
authors.affiliation: Department of Obstetrics and Gynecology, La Sapienza University, Rome, Italy.
authors.forename: Innocenza
authors.initials: I
authors.lastname: Palaia
authors.forename: Roberto
authors.initials: R
authors.lastname: Angioli
authors.forename: Filippo
authors.initials: F
authors.lastname: Bellati
authors.forename: Stefano
authors.initials: S
authors.lastname: Basile
authors.forename: Carla
authors.initials: C
authors.lastname: Rabitti
authors.forename: Pierluigi Benedetti
authors.initials: PB
authors.lastname: Panici
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D050278:Finger Phalanges / Q000473:pathology*; D006801:Humans; D008081:Liposomes; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010292:Paresthesia / Q000139:chemically induced*; D011092:Polyethylene Glycols
chemical_list: D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D011092:Polyethylene Glycols; D004317:Doxorubicin