Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination.
Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.
Ha
Sang-Jun
SJ
Division of Molecular and Life Sciences, Postech Biotech Center, Pohang University of Science & Technology, Hyoja-dong, Pohang, Korea.
Park
Su-Hyung
SH
Kim
Hye-Ju
HJ
Kim
Seung-Chul
SC
Kang
Hyang-Ju
HJ
Lee
Eun-Gae
EG
Kwon
Soon-Geon
SG
Kim
Byong-Moon
BM
Lee
Sung-Hee
SH
Kim
Won-Bae
WB
Sung
Young-Chul
YC
Cho
Sang-Nae
SN
D000217:Acyltransferases / Q000276:immunology; D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins; D002214:Capsules; D003692:Delayed-Action Preparations; D018664:Interleukin-12 / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008863:Microspheres; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity; D018417:Th1 Cells / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014611:Vaccination
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D002214:Capsules; D003692:Delayed-Action Preparations; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D032581:Tuberculosis Vaccines; D018664:Interleukin-12; D000217:Acyltransferases; C112580:antigen 85A, Mycobacterium tuberculosis