title: [Allergy towards bone cement].
abstract: Bone cements based on polymethylmethacrylate are typically used for fixation of artificial joints. Intolerance reactions to endoprostheses not explained by infection or mechanical failure may lead to allergological diagnostics, which mostly focuses on metal allergy. However, also bone cement components may provoke hypersensitivity reactions leading to eczema, implant loosening, or fistula formation. Elicitors of such reactions encompass acrylates and additives such as benzoyl peroxide, N,N-dimethyl-p-toluidine, hydroquinone, or antibiotics (particularly gentamicin). Upon repeated contact with bone cement components, e.g., acrylate monomers, also in medical personnel occasionally hand eczema or even asthma may develop. Therefore, in the case of suspected hypersensitivity reactions to arthroplasty, the allergological diagnostics should include bone cement components.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Frauenlobstrasse 9-11, 80337, München. Peter.Thomas@med.uni-muenchen.de
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: A
authors.initials: A
authors.lastname: Schuh
authors.forename: B
authors.initials: B
authors.lastname: Summer
authors.forename: F
authors.initials: F
authors.lastname: Mazoochian
authors.forename: M
authors.initials: M
authors.lastname: Thomsen
mesh_terms: D001843:Bone Cements / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects*; D019904:Polymethyl Methacrylate / Q000009:adverse effects*
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate