title: Mitomycin antitumour agents: a review of their physico-chemical and analytical properties and stability.
abstract: The review enumerates the physico-chemical and analytical properties of mitomycin antitumour antibiotics, of which mitomycin C is the most important representative. After a short overview of the position of the compounds in oncology the following subjects will be discussed: structural features, prototropic properties, spectroscopy (UV-VIS, ORD, CD, IR, NMR, MS), chromatography and electrochemistry. The chemical stability and aspects of the mechanism of action of the compounds are also discussed. The last part of the review surveys the analysis of mitomycin C in biological fluids.
authors.affiliation: Department of Analytical Pharmacy, Subfaculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511 GH Utrecht, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: H
authors.initials: H
authors.lastname: Lingeman
authors.forename: H A
authors.initials: HA
authors.lastname: Van Munster
authors.forename: W J
authors.initials: WJ
authors.lastname: Underberg