title: [Acute effects of low and moderate doses of alcohol on coordinate motor and autonomic nervous function in a group of healthy Hans].
abstract: The autonomic nervous function, blood pressure, coordinate motor and blood alcohol Concentration (BAG) of twenty-one healthy Han volunteers were examined before and after alcohol intake. The purpose was to assess the acute effects of low and moderate doses of alcohol on their coordinate motor and autonomic nervous function. The results showed that after alcohol intake the subjects' heart rate increased and the total power value (TPV) decreased significantly. After the intake of alcohol at low dose, the parasympathetic nervous function of the subjects lying supoine was inhibited significantly. After the intake of alcohol at moderate dose, both the parasympathetic and the sympathetic nervous functions were inhibited. After the intake of alcohol at low dose, both the systolic pressure and the diastolic pressure of the subjects standing up-right were decreased and the diastolic pressure of those lying supine were also decreased. After the intake of alcohol at moderate dose, the systolic and diastolic pressures of the subjects, either lying supine or standing up-right, were decreased. Some subjects showed ataxia after the intake of alcohol at low dose ,and some showed aggravated ataxia after intake of alcohol at moderate dose of alcohol. There was no relationship of BAG with the degree of changes in autonomic nervous function, blood pressure and ataxia. The results indicated that ataxia was induced to come on and the autonomic nervous function was inhibited in some subjects who had taken low and moderate doses of alcohol ,and the cardiovascular regulation was affected too. These suggested that the increase of alcohol intake is adverse to human body's adaptation to the sharp change of circumstance.
authors.affiliation: College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Xiujun
authors.initials: X
authors.lastname: Li
authors.forename: Shixiong
authors.initials: S
authors.lastname: Deng
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: Xie
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D002681:China / Q000208:ethnology; D004562:Electrocardiography / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D020234:Gait Ataxia / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male
chemical_list: D000431:Ethanol