title: Effect of cortical cleaving hydrodissection on posterior capsule opacification in age-related nuclear cataract.
abstract: OBJECTIVE
  To evaluate the effect of multiquadrant cortical cleaving hydrodissection on the development of posterior capsule opacification (PCO) after phacoemulsification.
  
  
  METHODS
  Iladevi Cataract and IOL Research Center, Ahmedabad, India.
  
  
  METHODS
  A prospective randomized triple blind clinical trial was conducted in 86 eyes (86 patients) having phacoemulsification. Eyes were assigned randomly to Group 1, multiquadrant cortical cleaving hydrodissection and hydrodelineation (n = 48 eyes), or Group 2, no multiquadrant cortical cleaving hydrodissection, only hydrodelineation (n = 38 eyes). Age-related nuclear sclerosis (grading system of 1 to 5) and age greater than 50 years were included. Diabetes mellitus and associated eye diseases were excluded. Standard phacoemulsification with implantation of an AcrySof MA30BA intraocular lens (IOL) was done in both groups. High-resolution digital retroillumination images of the posterior capsule were analyzed at 4 years using POCOman software. Seven patients dropped out (8.1%). Outcome measures were incidence and percentage area of PCO. Test of proportions, independent sample t test, and 95% confidence intervals (CIs) were noted.
  
  
  RESULTS
  In Groups 1 and 2, the mean age was 58 years +/- 4 (SD) and 57 +/- 5 years, respectively (P = .702; 95% CI, 1.90-2.81); mean follow-up was 48.4 +/- 2.5 months and 49.3 +/- 1.9 months, respectively (P = .687; 95% CI, 1.186-0.7856); incidence of PCO was 11 of 44 (25%) and 12 of 35 (34.3%), respectively (P = .317; 95% CI, 0.359-0.0889); percentage area of PCO was 14.3% and 25.6%, respectively (P = .006; 95% CI, -19.19 to -3.44). One of 44 eyes (2.27%) and 2 of 35 eyes (5.7%) in the groups, respectively, had a neodymium:YAG capsulotomy.
  
  
  CONCLUSIONS
  Although no difference was noted in the incidence of PCO, in eyes that had PCO, the percentage of the area of the central posterior capsule involved by PCO was significantly lower in eyes that had multiquadrant cortical cleaving hydrodissection than in those that did not.
authors.affiliation: Iladevi Cataract & IOL Research Centre, Raghudeep Eye Clinic, Ahmedabad, India. shailad1@sancharnet.in
authors.forename: Abhay R
authors.initials: AR
authors.lastname: Vasavada
authors.forename: Sheena A
authors.initials: SA
authors.lastname: Dholakia
authors.forename: Shetal M
authors.initials: SM
authors.lastname: Raj
authors.forename: Raminder
authors.initials: R
authors.lastname: Singh
mesh_terms: D000375:Aging; D002386:Cataract / Q000209:etiology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D007904:Lens Cortex, Crystalline / Q000601:surgery*; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D011183:Postoperative Complications; D011446:Prospective Studies