title: Pathways of neurodegeneration and experimental models of basal ganglia disorders: downstream effects of mitochondrial inhibition.
abstract: The basal ganglia circuit plays a key role in the regulation of voluntary movements as well as in behavioural control and cognitive functions. The main pathogenic role of mitochondrial dysfunctions is now accepted in the neurodegenerative process and the mitochondria have been successfully used as subcellular targets to obtain relevant experimental models of basal ganglia neurodegenerative disorders. Mitochondrial toxins act through an inhibition of the respiratory chain complexes. These toxins, by uncoupling cellular respiration, shift the cell into a state of oxidative stress and trigger several bidirectional links with the excitotoxic process. Moreover, the in vitro inhibition of the respiratory chain complexes alters the electrophysiological properties of the neurons. The downstream effects triggered by mitochondrial complexes inhibition provide a model integrating genetic and environmental pathogenic factors to explain the selective neuronal vulnerability.
authors.affiliation: Clinica Neurologica, Università degli Studi di Perugia, Ospedale Silvestrini, Perugia, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Di Filippo
authors.forename: Barbara
authors.initials: B
authors.lastname: Picconi
authors.forename: Cinzia
authors.initials: C
authors.lastname: Costa
authors.forename: Vincenza
authors.initials: V
authors.lastname: Bagetta
authors.forename: Michela
authors.initials: M
authors.lastname: Tantucci
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabresi
mesh_terms: D000818:Animals; D001480:Basal Ganglia Diseases / Q000378:metabolism*; D004195:Disease Models, Animal; D042967:Electron Transport Complex I / Q000378:metabolism; D042963:Electron Transport Complex II / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D009410:Nerve Degeneration / Q000378:metabolism*
chemical_list: D042963:Electron Transport Complex II; D042967:Electron Transport Complex I