Characterization of drug purity by liquid chromatography.
Applications of liquid chromatography (LC) in the characterization of drug purity are reviewed. Examples are given of the development of methods for the separation of impurities in acids, amines and neutral drug substances. A variety of methods and techniques are discussed including normal-phase and reversed-phase LC, gradient elution, and multidimensional separation systems.
Jansson
S O
SO
Analytical Chemistry, AB Hässle, S-431 83 Mölndal, Sweden.