title: Neuroparalysis and ventilatory support in severe tetanus.
abstract: In severe form of tetanus, even with maximum dose of muscle relaxants, spasms and apnoeic spells may persist and that may be life-threatening. The aim of this study was to assess the effect of neuroparalysing the patients and then providing ventilatory support in bringing about their recovery. Forty-nine adult patients of severe tetanus (Ablett's grade IIIA--6 patients and Ablett's grade IIIB--43 patients) were studied during the period from April, 1993 to February, 1996. Mean period of onset ie, period from trismus to first spasm, in these patients was 24 hours. Patients were neuroparalysed with a bolus dose of 2-4 mg of pancuronium followed by a continuous infusion of 1-2 mg/hour and simultaneously supported with mechanical ventilation until spasms subsided. Fourteen patients (28.6%) survived and rest died. Mean duration of ventilatory support on survived patients was 14.4 days. The commonest complication encountered during ventilatory support was respiratory tract infection observed in 36 patients (73.5%). Commonest cause of death was autonomic imbalance encountered in 15 patients (30.6%). Treatment of choice in severe tetanus should be neuroparalytic ventilatory support. With use of new generation ventilators and better intensive care facility, death in severe tetanus is likely to be very less.
authors.affiliation: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
authors.forename: T K
authors.initials: TK
authors.lastname: Dutta
authors.forename: A K
authors.initials: AK
authors.lastname: Das
authors.forename: K R
authors.initials: KR
authors.lastname: Sethuraman
authors.forename: R P
authors.initials: RP
authors.lastname: Swaminathan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010197:Pancuronium / Q000627:therapeutic use*; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D012133:Respiratory Paralysis / Q000139:chemically induced*; D013035:Spasm / Q000188:drug therapy*; D013742:Tetanus / Q000150:complications / Q000188:drug therapy*
chemical_list: D010197:Pancuronium