title: Antiviral defense: interferons and beyond.
abstract: Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon production and raise important questions regarding the nature of cell-autonomous virus detection in coordinating the antiviral response.
authors.affiliation: Howard Hughes Medical Institute, Yale University School of Medicine, CT 06520, USA. daniel.stetson@yale.edu
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Stetson
authors.forename: Ruslan
authors.initials: R
authors.lastname: Medzhitov
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000172:deficiency; D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D007370:Interferon Type I / Q000378:metabolism*; D051379:Mice; D009696:Nucleic Acids / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000998:Antiviral Agents; D007370:Interferon Type I; D009696:Nucleic Acids