title: A concise total synthesis of salinosporamide A.
abstract: A concise and straightforward 14-step total synthesis of (+/-)-salinosporamide A, based on a diastereoselective acid-catalysed intramolecular cyclisation of to the pyrrolidinone , and a regioselective reduction of the malonate derivative 8b to the aldehyde 9, is described.
authors.affiliation: School of Chemistry, University of Nottingham, England, UK. GP@nottingham.ac.uk
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Mulholland
authors.forename: Gerald
authors.initials: G
authors.lastname: Pattenden
authors.forename: Iain A S
authors.initials: IA
authors.lastname: Walters
mesh_terms: D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis*; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D061988:Proteasome Inhibitors; D011758:Pyrroles / Q000138:chemical synthesis*
chemical_list: D007783:Lactones; D011480:Protease Inhibitors; D061988:Proteasome Inhibitors; D011758:Pyrroles; C475865:marizomib