Forensic application of chiral separation of amphetamine-type stimulants to impurity analysis of seized methamphetamine by capillary electrophoresis.
The applicability of capillary electrophoresis (CE) with a UV detector using highly sulfated gamma-cyclodextrin as a chiral selector was examined for analysis of impurities in seized methamphetamine. Samples of methamphetamine-hydrochloride dissolved in water at a high concentration (20 mg/mL) were analyzed. Electrokinetic injection has an advantage over hydrodynamic injection for improving the detection of trace impurities. Small peaks of the precursor impurities, such as (1R,2S)-(-)-ephedrine and (1S,2S)-(+)-pseudoephedrine, were detected and quantified without extraction. The seized drugs could be classified into three groups based on the contents of the two impurities.
Iwata
Yuko T
YT
National Research Institute of Police Science, Kashiwanoha, Kashiwa, Chiba, Japan. togawa@nrips.go.jp
Inoue
Hiroyuki
H
Kuwayama
Kenji
K
Kanamori
Tatsuyuki
T
Tsujikawa
Kenji
K
Miyaguchi
Hajime
H
Kishi
Tohru
T