Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India.
BACKGROUND
Factor V Leiden has been reported in 2%-30% of patients with portal vein thrombosis. This wide variation makes it difficult to assess the importance of factor V Leiden as a predisposing factor.


METHODS
Factor V Leiden was determined by restriction fragment length polymorphism in 112 patients with portal vein thrombosis, 104 with deep vein thrombosis and 98 control subjects.


RESULTS
Only 3/112 (3%) patients with portal vein thrombosis had factor V Leiden, compared to 1/98 (1%) controls and 16/104 (15%) with deep vein thrombosis; of these, 3, 1 and 15, respectively, were heterozygous for this mutation.


CONCLUSIONS
Factor V Leiden contributes little, if at all, to the development of portal vein thrombosis in southern India.
Koshy
Abraham
A
Department of Gastroenterology and Molecular Biology Unit, Institute of Population Health and Clinical Research, St. John's Medical College Hospital, Bangalore - 560 034, India. koshyabe@yahoo.com
Jeyakumari
Mary
M
D020016:Activated Protein C Resistance / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D008642:Mesenteric Veins / Q000473:pathology; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011169:Portal Vein / Q000473:pathology*; D013162:Splenic Vein / Q000473:pathology; D020246:Venous Thrombosis / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V