Single-dose sertaconazole vaginal tablet treatment of vulvovaginal candidiasis.
BACKGROUND
Vulvovaginal candidiasis (WC) is a bothersome disease in women. Poor compliance with the continuous use of antifungal vaginal drugs often results in treatment failure. The aim of the present study was to evaluate the efficacy, acceptability, and safety of single-dose sertaconazole vaginal tablet (500 mg) treatment compared with conventional 3-dose econazole vaginal tablet (150 mg) treatment for VVC.


METHODS
In this open, randomized, and comparative study, 40 symptomatic patients with VVC confirmed by the smear method were enrolled. Patients in group A were treated with single-dose sertaconazole vaginal tablet and those in group B were treated continuously with econazole vaginal tablet for 3 days.


RESULTS
The characteristics of the patients in both groups were comparable and without statistical difference. Group A showed a significantly better clearance rate for candidiasis than group B (100% vs. 72.2% on day 7, p = 0.013; 100% vs. 77.8% on day 14, p = 0.030), based on smear method results. Group A showed a more rapid response for symptom relief than group B on day 7, but there was no difference in overall symptom relief between group A and group B on day 14.


CONCLUSIONS
Single-dose sertaconazole proved to be a more convenient and symptom-relieving treatment for VVC. The advantages of such management are worthy of further study in women with relapse VVC.
Wang
Peng-Hui
PH
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taiwan, ROC. phwang@vghtpe.gov.tw
Chao
Hsiang-Tai
HT
Chen
Cheng-Li
CL
Yuan
Chiou-Chung
CC
D000282:Administration, Intravaginal; D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D013607:Tablets; D013876:Thiophenes / Q000008:administration & dosage* / Q000009:adverse effects
D007093:Imidazoles; D013607:Tablets; D013876:Thiophenes; C061131:sertaconazole