title: Heart rate variability in diabetes patients.
abstract: Diabetes mellitus can cause cardiovascular autonomic neuropathy and is associated with increased cardiovascular deaths. We investigated cardiovascular autonomic neuropathy in diabetics and healthy controls by analysis of heart rate variability. Thirty-one diabetics and 30 age- and sex-matched controls were included. In the time domain we measured the mean R - R interval (NN), the standard deviation of the R - R interval index (SDNN), the standard deviation of the 5-min R - R interval mean (SDANN), the root mean square of successive R - R interval differences (RMSSD) and the percentage of beats with a consecutive R - R interval difference > 50 ms (pNN50). In the frequency domain we measured high-frequency power (HF), low-frequency power (LF) and the LF/HF ratio. Diabetes patients had lower values for time-domain and frequency-domain parameters than controls. Most heart rate variability parameters were lower in diabetes patients with chronic complications than in those without chronic complications.
authors.affiliation: Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. hkudat@istanbul.edu.tr
authors.forename: H
authors.initials: H
authors.lastname: Kudat
authors.forename: V
authors.initials: V
authors.lastname: Akkaya
authors.forename: A B
authors.initials: AB
authors.lastname: Sozen
authors.forename: S
authors.initials: S
authors.lastname: Salman
authors.forename: S
authors.initials: S
authors.lastname: Demirel
authors.forename: M
authors.initials: M
authors.lastname: Ozcan
authors.forename: D
authors.initials: D
authors.lastname: Atilgan
authors.forename: M T
authors.initials: MT
authors.lastname: Yilmaz
authors.forename: O
authors.initials: O
authors.lastname: Guven
mesh_terms: D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004562:Electrocardiography; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged