T-kininogen: a biomarker of aging in Fisher 344 rats with possible implications for the immune response.
T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG follows an exponential curve, whereas in females the increase is best fitted by a linear curve. In both genders, dietary restriction delays the increase in T-KG. We have previously shown that T-KG inhibits T lymphocyte proliferation. Here we show that serum T-KG levels correlate negatively with the ability of splenocytes (most likely B cells) to proliferate in response to lipopolysaccharide. A similar correlation was not observed with other markers of inflammation, including alpha1-acid glycoprotein (AGP), haptoglobin, or interleukin-10. We conclude that the increase in serum T-KG represents a useful biomarker of aging in Fisher 344, and it correlates with decreased lymphocyte proliferation with age, although a cause-effect relationship has not been established.
Acuña-Castillo
Claudio
C
Instituto de Ciencias Biomédicas, Progama de Biología Celular y Molecular, Facultad de Medina, Universidad de Chile, Santiago.
Leiva-Salcedo
Elias
E
Gómez
Christian R
CR
Pérez
Viviana
V
Li
Min
M
Torres
Claudio
C
Walter
Robin
R
Murasko
Donna M
DM
Sierra
Felipe
F
D000375:Aging / Q000097:blood* / Q000276:immunology; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D005260:Female; D007704:Kininogens / Q000097:blood* / Q000276:immunology; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D018709:Statistics, Nonparametric
D015415:Biomarkers; D007704:Kininogens