title: Effect of vaccination with recombinant canine distemper virus vaccine immediately before exposure under shelter-like conditions.
abstract: Vaccination with modified-live virus (MLV) canine distemper virus (CDV) vaccine has historically been recommended for animals in high-risk environments because of the rapid onset of immunity following vaccination. Recombinant CDV (rCDV) vaccine was deemed a suitable alternative to MLV-CDV vaccination in pet dogs, but insufficient data precluded its use where CDV was a serious threat to puppies, such as in shelters, kennels, and pet stores. In this study, dogs experimentally challenged hours after a single dose of rCDV or MLV vaccine became sick but recovered, whereas unvaccinated dogs became sick and died. Dogs vaccinated with a single dose of rCDV or MLV vaccine 1 week before being experimentally challenged remained healthy and showed no clinical signs. Dogs given one dose of rCDV vaccine hours before being placed in a CDV-contaminated environment did not become sick. These findings support the hypothesis that rCDV vaccine has a similar time-to-immunity as MLV-CDV vaccines and can likewise protect dogs in high-risk environments after one dose.
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, 2015 Linden Dr, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Larson
authors.forename: R D
authors.initials: RD
authors.lastname: Schultz
mesh_terms: D000818:Animals; D004216:Distemper / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology*; D004283:Dog Diseases / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D004285:Dogs; D006799:Housing, Animal / Q000145:classification; D011897:Random Allocation; D012307:Risk Factors; D013997:Time Factors; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
chemical_list: D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D014765:Viral Vaccines