title: Correction of massive hydrocephalus and brain wound in holoprosencephaly.
abstract: Holoprosencephaly is a rare disorder of embryologic development that denotes an incomplete or absent division of the embryonic forebrain (prosencephalon) into distinct lateral cerebral hemispheres. In most cases of holoprosencephaly, the fetus fails to survive to term, and those that do survive have severe functional limitations, including mental retardation. We present a case report of cranial vault remodeling in a 20-month-old female who was born with holoprosencephaly and a severe number 0/14 cleft. The patient developed chronic nonhealing ulcers secondary to hydrocephalus, ventriculoperitoneal shunts, and the underlying architecture of her cranial vault.
authors.affiliation: Division of Plastic and Reconstructive Surgery, University of California Los Angeles (UCLA) School of Medicine, Los Angeles, California 90095-6960, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Dickinson
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Spoon
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Cordray
authors.forename: Jorge
authors.initials: J
authors.lastname: Lazareff
authors.forename: Kristy
authors.initials: K
authors.lastname: Wasson
authors.forename: James P
authors.initials: JP
authors.lastname: Bradley
mesh_terms: D020341:Absorbable Implants; D001860:Bone Plates; D016025:Bone Transplantation; D003399:Craniotomy; D005260:Female; D016142:Holoprosencephaly / Q000150:complications / Q000601:surgery*; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000601:surgery*; D007223:Infant; D019651:Plastic Surgery Procedures / Q000379:methods; D012883:Skin Ulcer / Q000209:etiology; D012886:Skull / Q000002:abnormalities / Q000601:surgery*; D017287:Ventriculoperitoneal Shunt