[Possible mechanisms of small bowel propulsion regulation within early periods after abdominal cavity organ surgeries].
The impact of various prokinetic drugs on small bowel propulsion was studied in a rat model at the post-surgical period (laparotomy plus manipulation of the gut). Intestinal transit was measured by the migration of Evans blue marker. It was shown that the small bowel transit was decelerated after laparotomy. All drugs improved the small bowel propulsion but it turned out that nitric oxide as the key inhibitory non-adrenergic non-cholinergic neurotransmitter played the main part in the pathogenesis of post-surgical small bowel propulsion inhibition.
Tropskaia
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NS
D034841:Abdominal Cavity / Q000601:surgery*; D000818:Animals; D005772:Gastrointestinal Transit / Q000187:drug effects / Q000502:physiology*; D007583:Jejunum / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009569:Nitric Oxide / Q000502:physiology*; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar
D009569:Nitric Oxide