Protein-mediated fatty acid uptake: novel insights from in vivo models.
Long-chain fatty acids are both important metabolites as well as signaling molecules. Fatty acid transport proteins are key mediators of cellular fatty acid uptake and recent transgenic and knockout animal models have provided new insights into their contribution to energy homeostasis and to pathological processes, including obesity and insulin desensitization.
Doege
Holger
H
Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA.
Stahl
Andreas
A
D000818:Animals; D030801:Animals, Genetically Modified; D001692:Biological Transport / Q000502:physiology; D050612:Fatty Acid Transport Proteins / Q000235:genetics / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D009765:Obesity / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology
D050612:Fatty Acid Transport Proteins; D005227:Fatty Acids