[Effect of leu-enkephalin on potassium currents in neurons of the respiratory center of rats in vitro].
Action of opioid peptide: leu-enkephalin (10 nM - 1 microM), on K+A-current and inward rectifier in neurons of two divisions of the respiratory center: ventrolateral area of the solitary tract nucleus and the pre-Botzinger complex, was investigated in brainstem slices of Wistar rats by whole-cell voltage-clamp recordings. A-current and inward rectifier were found in all the neurons under study. A-current did not change after the application of leu-enkephalin to the bath solution while the amplitude of inward rectifier did reversibly increase. The data obtained suggest that the inhibitory effect of leu-enkephalin on neurons of the respiratory center, at least in part, can be based on its ability to modulate inward rectifier.
Iniushkin
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D000818:Animals; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D017136:Ion Transport / Q000187:drug effects; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012125:Respiratory Center / Q000378:metabolism*
D018377:Neurotransmitter Agents; D004743:Enkephalin, Leucine; D011188:Potassium