title: Two neolignan glucosides and antihistamine release activities from Bidens parviflora WILLD.
abstract: Two new neolignan glucosides, bidenlignasides A (1) and B (2), were isolated from the whole plant of Bidens parviflora WILLD. The structures of the two new compounds 1 and 2 established to be 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-[5E-(3-hydroxypropenyl)-3-methoxy-2-O-beta-D-glucosyl)phenyl] propan-1-one and 3-{3-[1,3-dihydroxy-3-(4-hydroxy-3-methoxyphenyl)propyl]-4-hydroxy-5-methoxyphenyl}-allyl-O-beta-D-glucuside, respectively, on the basis of spectral and chemical evidence. Compounds 1 and 2 were found to inhibit histamine release from peritoneal exudate mast cells induced by antigen-antibody reaction.
authors.affiliation: Department of Natural Products Chemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Shanyang 110015, China. wangnl@sz.tsinghua.edu.cn
authors.forename: Nai Li
authors.initials: NL
authors.lastname: Wang
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Xin Sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031176:Bidens / Q000737:chemistry*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects* / Q000502:physiology; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
chemical_list: D018926:Anti-Allergic Agents; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D007783:Lactones; D017705:Lignans; D010636:Phenols; C513995:bidenlignaside A; C513996:bidenlignaside B