Murine model of infection by Tropheryma whipplei.
We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.
Genot
Séverine
S
Unité des Rickettsies, CNRS UMR 6020, Faculté de Médecine, Université de la Méditerranée, 27 Bld. Jean Moulin, 13385 Marseille Cedex 05, France.
Stein
Andreas
A
Lepidi
Hubert
H
Ihrig
Melanie
M
Raoult
Didier
D
Mege
Jean-Louis
JL
D000192:Actinomycetales / Q000472:pathogenicity*; D000193:Actinomycetales Infections / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008099:Liver / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D008061:Whipple Disease / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*