Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility.
A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C. albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.
Katiyar
Santosh
S
Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Pfaller
Michael
M
Edlind
Thomas
T
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D041221:Candida glabrata / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D002177:Candidiasis / Q000382:microbiology; D017124:Conserved Sequence; D025141:Drug Resistance, Fungal / Q000235:genetics; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid
D000935:Antifungal Agents; D005656:Fungal Proteins; D010456:Peptides, Cyclic; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase