High levels of thymidine phosphorylase as an independent prognostic factor in renal cell carcinoma.
BACKGROUND
We investigated whether thymidine phosphorylase (TP) protein level in renal cell carcinoma (RCC) correlates with clinicopathological characteristics and clinical outcomes.


METHODS
TP protein level was measured in 116 RCC specimens and in 90 non-neoplastic kidney tissues using a sandwich-type enzyme-linked immunosolvent assay.


RESULTS
The median TP protein level in RCC tissues was 9.76-fold (range, 3.2-933.9) higher than those in non-neoplastic kidney tissues (P < 0.0001). TP protein level was correlated with T classification, histological grade and mode of infiltration. TP as a prognostic variable was studied using a logistic regression model. TP at higher levels (128 U/mg protein or greater) would play a role as an independent prognostic factor (odds ratio, 13.73; 95% confidence interval, 2.09-90.41; P = 0.0064).


CONCLUSIONS
TP at high levels can be regarded as an unfavorable independent prognostic factor. These results may pave a way for a novel approach to effective treatment of RCC.
Takayama
Tatsuya
T
Department of Urology, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. takayama@hama-med.ac.jp
Mugiya
Soichi
S
Sugiyama
Takayuki
T
Aoki
Takahiro
T
Furuse
Hiroshi
H
Liu
Hongming
H
Hirano
Yasuhiro
Y
Kai
Fumitake
F
Ushiyama
Tomomi
T
Ozono
Seiichiro
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000201:enzymology*; D007680:Kidney Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D013939:Thymidine Phosphorylase / Q000032:analysis / Q000378:metabolism*
D014408:Biomarkers, Tumor; D013939:Thymidine Phosphorylase