MDM2 309T>G polymorphism and risk of lung cancer in a Korean population.
BACKGROUND
The MDM2 protein plays an important role in regulating cell proliferation and apoptosis by interaction with multiple proteins including p53 and Rb. A polymorphism (309T>G) in the MDM2 promoter has been shown to result in higher levels of MDM2 RNA and protein. In order to evaluate the association of the MDM2 309T>G polymorphism and lung cancer risk, we carried out a case-control study in a Korean population.


METHODS
The MDM2 genotypes were determined in 582 lung cancer patients and in 582 healthy control subjects who were frequency matched for age and gender.


RESULTS
The distribution of the MDM2 309T>G genotypes was not significantly different between overall lung cancer cases and controls. However, when the cases were categorized by tumor histology, the 309GG genotype was associated with a significantly increased risk of adenocarcinoma (adjusted OR=1.91, 95% CI=1.16-3.14, P=0.01) compared to the 309TT genotype. In addition, the risk of adenocarcinoma increased as the number of 309G alleles increased (P(trend)=0.01).


CONCLUSIONS
Our findings suggest that the MDM2 309T>G polymorphism may be used as a marker for genetic susceptibility to adenocarcinoma of the lung.
Park
Sun Ha
SH
Cancer Research Institute, Kyungpook National University Hospital, Samduk 2Ga 50, Daegu 700-412, Republic of Korea.
Choi
Jin Eun
JE
Kim
Eun Jin
EJ
Jang
Jin Sung
JS
Han
Hyung Soo
HS
Lee
Won Kee
WK
Kang
Young Mo
YM
Park
Jae Yong
JY
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea; D016015:Logistic Models; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors
C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2