title: [Signal transduction of IL-3 in regulating hematopoietic stem cell proliferation and differentiation].
abstract: IL-3 is also called as multi-lineage colony stimulating factor, which can positively regulate proliferation and differentiation of hematopoietic stem cell. After binding to its receptor on target cell, IL-3 can regulate hematopoietic stem cell to survive, proliferate, differentiate or to mature by transmitting growth, proliferation and differentiation signals. This paper is to summarize the signal transduction pathways of IL-3 in regulating hematopoietic stem cell proliferation and differentiation.
authors.affiliation: Department of Physiology, Chongqing University of Medical Science, Chongqing 400016, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guan
authors.forename: Sha-Li
authors.initials: SL
authors.lastname: Wang
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Wang
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D007377:Interleukin-3 / Q000378:metabolism / Q000502:physiology*; D053614:Janus Kinase 2 / Q000502:physiology; D020929:Mitogen-Activated Protein Kinase Kinases / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D015398:Signal Transduction
chemical_list: D007377:Interleukin-3; D019869:Phosphatidylinositol 3-Kinases; D053614:Janus Kinase 2; D020929:Mitogen-Activated Protein Kinase Kinases