title: Obsessive compulsive disorder treatment in patients with Down syndrome: a case series.
abstract: In this case series we report four cases of patients with Down syndrome with symptoms consistent with obsessive compulsive disorder. Each patient experienced substantial reduction in compulsive behaviors with pharmacotherapy of an SSRI alone or with the addition of risperidone to SSRI therapy. None of the patients experienced significant side effects. This small case series supports the use of these medications in the treatment of co-morbid obsessive compulsive disorder in patients with Down syndrome.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 5905, USA. sutor.bruce@mayo.edu
authors.forename: Bruce
authors.initials: B
authors.lastname: Sutor
authors.forename: Mark R
authors.initials: MR
authors.lastname: Hansen
authors.forename: John L
authors.initials: JL
authors.lastname: Black
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D004314:Down Syndrome / Q000150:complications*; D004409:Dyskinesia, Drug-Induced / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000188:drug therapy*; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone; D017367:Selective Serotonin Reuptake Inhibitors