title: Electrochemical behaviour of cis-platin at carbon paste and platinum electrodes.
abstract: The electrochemical behaviour of a platinum(II) anti-tumour drug (cis-platin) has been investigated at the platinised platinum and carbon paste electrodes using cyclic voltammetry. Measurements performed in neutral aqueous media at the platinised platinum electrode as a function of free chloride ions have enabled the nature of oxidised species to be established and the sensitive determination of the molecule within the range of concentration 1 x 10(-3) - 1 x 10(-5) M to be realised. Use of the carbon paste electrode offers interesting insights into the redox stability of the molecule and allows the hydrolytic degradation of cis-platin to be followed as a function of time.
authors.affiliation: Free University of Brussels, Pharmaceutical Institute Campus de la Plaine 205/6, Bd. du Triomphe, B-1050 Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Mebsout
authors.forename: J M
authors.initials: JM
authors.lastname: Kauffmann
authors.forename: G J
authors.initials: GJ
authors.lastname: Patriarche