title: Derivatization reactions in the gas-liquid chromatographic analysis of drugs in biological fluids.
abstract: Alkylation, acylation, silylation and other derivatization reactions applied to the gas chromatographic analysis of drugs in biological matrices are reviewed. Reaction conditions are discussed in relation to reaction mechanisms. Detector-oriented labelling of drugs, and derivatization with chiral reagents for the separation of enantiomers are surveyed. Data on the sample clean-up, derivatization and GLC analysis of more than 300 drugs and related compounds are listed.
authors.affiliation: Department of Analytical Pharmacy, University of Utrecht, Pharmaceutical Laboratory, Catherijnesingel 60, 3511 GH Utrecht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Hulshoff
authors.forename: H
authors.initials: H
authors.lastname: Lingeman