title: Influenza vaccination for healthcare workers who work with the elderly.
abstract: BACKGROUND
  Healthcare workers (HCW) (nurses, doctors, other health professionals, cleaners and porters), have substantial rates of clinical and sub-clinical influenza during influenza seasons and may transmit influenza to those in their care, especially the vulnerable elderly.
  
  
  OBJECTIVE
  To identify and summarise comparative studies assessing the effects of vaccinating healthcare workers (HCW) on the incidence of influenza, influenza-like-illness (ILI) and its complications on elderly residents in long-term facilities.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CENTRAL), the Cochrane Database of Systematic Reviews and the NHS Database of Abstracts of Reviews of Effectiveness (DARE) (The Cochrane Library Issue 1, 2006); MEDLINE (January 1966 to Week 1, February 2006); EMBASE (1974 to March 2006); Biological Abstracts (1969 to December 2004); and Science Citation Index-Expanded (1974 to March 2006).
  
  
  METHODS
  Comparative randomised and non-randomised studies reporting the effects of influenza vaccines on the incidence of viral infections in institutions for the elderly of any type, in any schedule of vaccination given to HCW caring for elderly residents of long-term facilities aged 60 years or older.
  
  
  METHODS
  Two authors independently extracted data and assessed the methodological quality using criteria from the Cochrane Reviewers' Handbook and the Newcastle-Ottawa scale (for non-randomised studies).
  
  
  RESULTS
  We included two cluster randomised controlled trials (C-RCT) and one cohort study. Staff vaccination appears to have significant effect against ILI (absolute vaccine efficacy (VE) 86%, 95% confidence interval (CI) 40% to 97%) only when patients are vaccinated too; if patients are not vaccinated, staff immunisation shows no effect (based on one C-RCT). Based on a small number of observations from two C-RCTs, the vaccines have no efficacy against influenza (odds ratio (OR) 0.86, 95% CI 0.44 to 1.68) or lower respiratory tract infections (OR 0.70, 95% CI 0.41 to 1.20) but were effective against deaths from pneumonia (VE 39%, 95% CI 2% to 62%) and deaths from all causes (VE 40%, 95% CI 27% to 50%). All findings must be interpreted with caution given the presence of selection bias.
  
  
  CONCLUSIONS
  We concluded that there is no credible evidence that vaccination of healthy people under the age of 60, who are HCWs caring for the elderly, affects influenza complications in those cared for. However, as vaccinating the elderly in institutions reduces the complications of influenza and vaccinating healthy persons under 60 reduces cases of influenza, those with the responsibility of caring for the elderly in institutions may want to increase vaccine coverage and assess its effects in well-designed studies.
authors.affiliation: University of Calgary, Department of Medicine, UCMC, #1707-1632 14th Avenue, Calgary, Alberta, Canada T2M 1N7. rthomas@ucalgary.ca
authors.forename: R E
authors.initials: RE
authors.lastname: Thomas
authors.forename: T
authors.initials: T
authors.lastname: Jefferson
authors.forename: V
authors.initials: V
authors.lastname: Demicheli
authors.forename: D
authors.initials: D
authors.lastname: Rivetti
mesh_terms: D000328:Adult; D000368:Aged; D006282:Health Personnel; D006707:Homes for the Aged; D006801:Humans; D017757:Infectious Disease Transmission, Professional-to-Patient / Q000517:prevention & control*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000517:prevention & control / Q000635:transmission*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D015164:Vaccines, Inactivated / Q000008:administration & dosage
chemical_list: D007252:Influenza Vaccines; D015164:Vaccines, Inactivated