Hepatitis B virus-human immunodeficiency virus co-infection in France: a cross-sectional multicentre study.
This prospective, multicentre study was conducted between September and October 2003 in 38 French departments of internal medicine, infectious disease and hepatogastroenterology and included 406 consecutive HBV-infected patients (positive HBsAg), half of whom were HIV-infected (53%). The aim was to outline the main characteristics of hepatitis B virus (HBV)-human immunodeficiency virus (HIV) co-infected patients in French hospitals. HBV-HIV co-infected patients (85% were receiving HAART; mean CD4 count 447+/-245/microl, HIV RNA load<400 copies/ml, 67% of patients), compared to HIV-negative patients, were more often male, injecting drug users, HBeAg-positive and HCV-HIV co-infected (P<10(-4)). They underwent liver biopsy less often (31% vs. 51%, P<10(-4)), particularly those with severe immunodeficiency. They received anti-HBV treatment more often (75% vs. 45.7%, P<10(-4)), mainly lamivudine and tenofovir. Significant improvements in the management of such patients are awaited mainly in the appraisal of liver disease by either liver biopsy or non-invasive alternatives to liver biopsy.
Sène
D
D
Hopital La Pitié-Salpétrière, Service de Médecine Interne, Paris, France.
Pol
S
S
Piroth
L
L
Goujard
C
C
Dellamonica
P
P
Moussali
J
J
Rey
D
D
Loustaud-Ratti
V
V
Alric
L
L
Chousterman
M
M
Borsa-Lebas
F
F
Boucher
O
O
Séréni
D
D
Cacoub
P
P
D000328:Adult; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000097:blood; D005260:Female; D005602:France; D015658:HIV Infections / Q000150:complications*; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D004279:DNA, Viral