Determination of fluperlapine in human plasma by capillary gas chromatography.
A sensitive and simple gas chromatographic method was developed for the determination of fluperlapine in human blood plasma using amitriptyline as an internal standard. The compounds were extracted into diethyl ether, the extract chromatographed on a dimethyl silicone capillary column, and detected by nitrogen phosphorus selective flame ionization detector. The NP-FID responses, as peak area ratios of the compound and internal standard, were linearly correlated to their plasma concentrations between 10 and 1000 ng/ml. The limit of detection in plasma was 0.5 ng/ml. The relative recovery of fluperlapine was about 85%.
Olajos
S
S
Laboratory of Pharmacokinetics, National Institute for Nervous and Mental Diseases, P.O. Box 1, 1281 Budapest, Hungary.
Sztaniszlav
D
D