title: Bayesian reanalysis of a quantitative trait locus accounting for multiple environments by scaling in broilers.
abstract: A Bayesian method was developed to handle QTL analyses of multiple experimental data of outbred populations with heterogeneity of variance between sexes for all random effects. The method employed a scaled reduced animal model with random polygenic and QTL allelic effects. A parsimonious model specification was applied by choosing assumptions regarding the covariance structure to limit the number of parameters to estimate. Markov chain Monte Carlo algorithms were applied to obtain marginal posterior densities. Simulation demonstrated that joint analysis of multiple environments is more powerful than separate single trait analyses of each environment. Measurements on broiler BW obtained from 2 experiments concerning growth efficiency and carcass traits were used to illustrate the method. The population consisted of 10 full-sib families from a cross between 2 broiler lines. Microsatellite genotypes were determined on generations 1 and 2, and phenotypes were collected on groups of generation 3 animals. The model included a polygenic correlation, which had a posterior mean of 0.70 in the analyses. The reanalysis agreed on the presence of a QTL in marker bracket MCW0058-LEI0071 accounting for 34% of the genetic variation in males and 24% in females in the growth efficiency experiment. In the carcass experiment, this QTL accounted for 19% of the genetic variation in males and 6% in females.
authors.affiliation: Istituto Zooprofilattico Sperimentale della Sicilia A. Mirri, Via G. Marinuzzi 3, 90129 Palermo, Italy. jtkaam@unipa.it
authors.forename: J B C H M
authors.initials: JB
authors.lastname: van Kaam
authors.forename: M C A M
authors.initials: MC
authors.lastname: Bink
authors.forename: D O
authors.initials: DO
authors.lastname: Maizon
authors.forename: J A M
authors.initials: JA
authors.lastname: van Arendonk
authors.forename: R L
authors.initials: RL
authors.lastname: Quaas
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D001499:Bayes Theorem; D002645:Chickens / Q000235:genetics* / Q000254:growth & development / Q000502:physiology*; D003198:Computer Simulation; D005260:Female; D005819:Genetic Markers; D008297:Male; D008390:Markov Chains; D008954:Models, Biological; D009010:Monte Carlo Method; D020412:Multifactorial Inheritance; D040641:Quantitative Trait Loci / Q000235:genetics*; D012727:Sex Characteristics; D015430:Weight Gain
chemical_list: D005819:Genetic Markers