Identification of a peptide mimic of bioactive gibberellins with affinity to GA 2-oxidase.
Previously we reported the first example of peptide mimics of a small hydrophobic molecule, a phytohormone gibberellin. The second peptide mimic of gibberellin has been identified from random peptide libraries by its affinity to a type of catalyzing enzyme of gibberellins, which specifically recognizes bioactive gibberellins. These results suggest that even hydrophobic compounds can be mimicked by peptides.
Sekimoto
Haruko
H
Department of Applied Biological Chemistry, The University of Tokyo, Japan.
Park
Seung-Hyun
SH
Nakajima
Masatoshi
M
Yamaguchi
Isomaro
I
Suzuki
Yoshihito
Y
D002384:Catalysis; D005875:Gibberellins / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D006899:Mixed Function Oxygenases / Q000737:chemistry*; D018716:Molecular Mimicry; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*; D013329:Structure-Activity Relationship
D005875:Gibberellins; D019151:Peptide Library; D010455:Peptides; D006899:Mixed Function Oxygenases; C121463:gibberellin 2-dioxygenase