title: Improving QTL mapping resolution based on genotypic sampling--a case using a RIL population.
abstract: The QTL mapping results were compared with the genotypically selected and random samples of the same size on the base of a RIL population. The results demonstrated that there were no obvious differences in the trait distribution and marker segregation distortion between the genotypically selected and random samples with the same population size. However, a significant increase in QTL detection power, sensitivity, specificity, and QTL resolution in the genotypically selected samples were observed. Moreover, the highly significant effect was detected in small size of genotypically selected samples. In QTL mapping, phenotyping is a more sensitive limiting factor than genotyping so that the selection of samples could be an attractive strategy for increasing genome-wide QTL mapping resolution. The efficient selection of samples should be more helpful for QTL maker assistant selection, fine mapping, and QTL cloning.
authors.affiliation: National Maize Improvement Center of China, China Agricultural University, Beijing 100094, China. yjianbing@cau.edu.cn
authors.forename: Jian-Bing
authors.initials: JB
authors.lastname: Yan
authors.forename: Ji-Hua
authors.initials: JH
authors.lastname: Tang
authors.forename: Yi-Jiang
authors.initials: YJ
authors.lastname: Meng
authors.forename: Xi-Qing
authors.initials: XQ
authors.lastname: Ma
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Teng
authors.forename: Subhash
authors.initials: S
authors.lastname: Chander
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Li
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D005787:Gene Frequency / Q000235:genetics; D005821:Genetic Techniques; D018745:Genome, Plant / Q000235:genetics*; D005838:Genotype; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*