title: Nanowires network for biomolecular detection using contactless impedance tomoscopy technique.
abstract: Here we present the detection of ultralow concentrations of biomolecules in a device made from a polycarbonate membrane containing a network of gold nanowires and using a "contactless" impedance tomoscopy technique. The sensor comprises a thin dielectric layer with two parallel band electrodes on the one side and a microchannel containing gold nanowires onto which the adsorption of antibodies occurs. Upon applying a high-frequency ac voltage between the two electrodes, the adsorption process occurring at the surface of the gold nanowires can be followed through contactless impedance measurements. The configuration allows the real-time detection of biomolecules with a bulk concentration in the picomolar range.
authors.affiliation: Laboratoire d'Electrochimie Physique et Analytique, ISIC-Station 6, and Laboratoire de Physique des Matériaux Nanostructurés, IPN-Station 3, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Gamby
authors.forename: J-P
authors.initials: JP
authors.lastname: Abid
authors.forename: M
authors.initials: M
authors.lastname: Abid
authors.forename: J-P
authors.initials: JP
authors.lastname: Ansermet
authors.forename: H H
authors.initials: HH
authors.lastname: Girault
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D007074:Immunoglobulin G / Q000032:analysis*; D008567:Membranes, Artificial; D053770:Nanowires / Q000737:chemistry*; D010316:Particle Size; D011076:Polycarboxylate Cement / Q000737:chemistry; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D008567:Membranes, Artificial; D011076:Polycarboxylate Cement; C005506:polycarbonate; D006046:Gold; D004247:DNA