Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue.
We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the insertion of the aromatic residue could increase the reactivity of the amino group on oligonucleotides in comparison with conventional amino-modification.
Kojima
Naoshi
N
Research Institute of Genome-based Biofactory, National Institute of Advanced Industrial Science and Technology, AIST, 2-17-2-1 Tsukisamu-Higashi, Sapporo 062-8517, Japan.
Sugino
Maiko
M
Mikami
Akiko
A
Nonaka
Ken
K
Fujinawa
Yumi
Y
Muto
Isamu
I
Matsubara
Kenichi
K
Ohtsuka
Eiko
E
Komatsu
Yasuo
Y
D000588:Amines / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis*; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry; D013329:Structure-Activity Relationship
D000588:Amines; D003432:Cross-Linking Reagents; D009841:Oligonucleotides; D011084:Polycyclic Aromatic Hydrocarbons