title: Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele.
abstract: In 29 adults with attention deficit hyperactivity disorder (ADHD) striatal dopamine transporter (DAT) availability was assessed by [(99m)Tc]TRODAT-1 SPECT and correlated with 3' VNTR polymorphism of the DAT gene on chromosome 5p15.3. Seventeen patients showed homozygosity for the 10-repeat allele, two homozygosity of the 9 allele and 10 were heterozygous (9-10). No statistically significant difference in DAT availability was found between patients with 10-10 carriers (DAT 1.28 +/- 0.34) and with at least one 9 allele (DAT 1.31 +/- 0.27); when smokers were excluded, DAT availability was 1.38 +/- 0.28 in the 10-10 carriers (n = 12) and 1.42 +/- 0.19 in the 9-10 and 9-9 carriers (n = 7). In conclusion, no higher striatal DAT was found in patients with homozygosity of the 10 allele of the DAT gene in this study. These results differ from a study in 11 Korean children with ADHD, in which 10-10 carriers showed higher DAT availability in [(123)I]IPT SPECT. Discrepancies may be explained by differences in patient's age, ethnical differences, different imaging techniques or the limited number of patients included in both studies.
authors.affiliation: Outpatient Clinic for Psychiatry and Psychotherapy, Ottobrunn, Germany. drjkrause@yahoo.com
authors.forename: Johanna
authors.initials: J
authors.lastname: Krause
authors.forename: Stefan H
authors.initials: SH
authors.lastname: Dresel
authors.forename: Klaus-Henning
authors.initials: KH
authors.lastname: Krause
authors.forename: Christian
authors.initials: C
authors.lastname: La Fougère
authors.forename: Peter
authors.initials: P
authors.lastname: Zill
authors.forename: Manfred
authors.initials: M
authors.lastname: Ackenheil
mesh_terms: D000328:Adult; D000367:Age Factors; D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000000981:diagnostic imaging / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003431:Cross-Cultural Comparison; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D005091:Exons; D005260:Female; D006580:Genetic Carrier Screening; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D015609:Organotechnetium Compounds; D011110:Polymorphism, Genetic / Q000235:genetics*; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; C493214:SLC6A3 protein, human; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1