A new entry to polycyclic indole skeletons via palladium-catalyzed intramolecular heteroannulation.
[reaction: see text] A one-step method was developed for elaboration of a variety of polycyclic indole skeletons via a novel palladium-catalyzed intramolecular indolization of 2-chloroanilines bearing tethered acetylenes. This novel intramolecular indolization method unveils an unusual syn amidopalladation pathway of a tethered alkyne.
Liu
Jianxiu
J
Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., 800 East Leigh Street, Suite 205, Richmond, Virginia 23219, USA.
Shen
Ming
M
Zhang
Yongda
Y
Li
Guisheng
G
Khodabocus
Ahmad
A
Rodriguez
Sonia
S
Qu
Bo
B
Farina
Vittorio
V
Senanayake
Chris H
CH
Lu
Bruce Z
BZ
D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000480:Alkynes; D026121:Indole Alkaloids; D010165:Palladium