title: Regular physical activity increases glutathione peroxidase activity in adolescents with Down syndrome.
abstract: OBJECTIVE
  The present study was designed to determine the influence of a 12-week exercise program on the activity of erythrocyte glutathione peroxidase (GPX) in adolescents with Down syndrome.
  
  
  METHODS
  An interventional study with before-after comparison.
  
  
  METHODS
  Sport Medicine School, University of Cadiz (Andalusia, Spain).
  
  
  METHODS
  Thirty-one male adolescents (16.3+/-1.1) with Down syndrome. None of them suffered acute medical problems at that moment and had not taken part in any physical activity program in the last 6 months.
  
  
  METHODS
  A 12-week training program with 3 days per week, consisting of warm up (15 min) followed by a main part (20 to 35 min) at a work intensity of 60% to 75% of peak heart rate (HRmax=194.5-[0.56xage]) and by a cool-down period (10 min).
  
  
  METHODS
  Erythrocyte activity of GPX.
  
  
  RESULTS
  Preexercise and postexercise GPX activity in adolescents with Down syndrome were 24.8+/-3.1 [23.1 to 26.5] U/g hemoglobin and 29.3+/-2.9 [28.1 to 30.5] U/g hemoglobin, respectively. When compared with baseline values it was increased significantly (24.8+/-3.1 vs. 29.3+/-2.9; P=0.011).
  
  
  CONCLUSIONS
  Regular exercise increased significantly GPX activity. Further studies are required to assess the behavior of other antioxidant enzymes to highlight potential benefits of regular exercise in redox metabolism.
authors.affiliation: Human Anatomy and Embryology, Medicine Department, Sport Medicine School, University of Cadiz, Spain.
authors.forename: Ordonez
authors.initials: O
authors.lastname: Francisco Javier
authors.forename: Rosety
authors.initials: R
authors.lastname: Manuel
authors.forename: Rosety-Rodriguez
authors.initials: RR
authors.lastname: Manuel
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism / Q000502:physiology; D004314:Down Syndrome / Q000201:enzymology* / Q000503:physiopathology; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005081:Exercise Therapy; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase