Morphometric study of gender differences with regard to age-related changes in the C57BL/6 mouse kidney.
To investigate gender differences with regard to age-related changes in the mouse kidney, kidneys from male and female C57BL/6Cr mice were morphometrically examined at 2, 4, 12, 27 and 33 months of age. Gender differences were clearly observed in age-related changes in renal corpuscle diameter, in addition to semiquantitative scores of glomerular damage and interstitial fibrosis. A greater relative increase in renal corpuscle diameter was observed in females compared to males, and scores indicating glomerular damage and interstitial fibrosis were more severe in males than in females.
Yabuki
Akira
A
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
Tanaka
Shin
S
Matsumoto
Mitsuharu
M
Suzuki
Shusaku
S
D000375:Aging / Q000502:physiology; D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D007668:Kidney / Q000033:anatomy & histology*; D007672:Kidney Cortex / Q000648:ultrastructure; D008297:Male; D051379:Mice / Q000033:anatomy & histology* / Q000502:physiology; D008810:Mice, Inbred C57BL; D012737:Sex Factors