title: Triterpene saponins from Eryngium campestre.
abstract: Five new triterpene saponins, 3-O-alpha-l-rhamnopyranosyl-(1-->2)-beta-d-glucuronopyranosyl-22-O-beta,beta-dimethylacryloyl-A1-barrigenol (1), 3-O-alpha-l-rhamnopyranosyl-(1-->2)-beta-d-glucuronopyranosyl-22-O-angeloyl-R1-barrigenol (2), 3-O-alpha-l-rhamnopyranosyl-(1-->2)-beta-d-glucuronopyranosyl-21-O-acetyl-22-O-angeloyl-R1-barrigenol (3), 3-O-alpha-l-rhamnopyranosyl-(1-->2)-beta-d-glucuronopyranosyl-21-O-acetyl-22-O-beta,beta-dimethylacryloyl-R1-barrigenol (4), and 3-O-alpha-l-rhamnopyranosyl-(1-->2)-beta-d-glucuronopyranosyl-22-O-angeloyl-28-O-acetyl-R1-barrigenol (5), were isolated from the roots of Eryngium campestre. Their structures were established mainly by 2D NMR techniques and mass spectrometry. Compounds 1-4 and 3-O-beta-d-glucopyranosyl-(1-->2)-[alpha-l-rhamnopyranosyl-(1-->4)]-beta-d-glucuronopyranosyl-22-O-beta,beta-dimethylacryloyl-A1-barrigenol, previously isolated from the same plant, showed a weak cytotoxicity when tested against HCT 116 and HT 29 human colon cancer cells.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100 Tandogan-Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kartal
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Mitaine-Offer
authors.forename: Thomas
authors.initials: T
authors.lastname: Paululat
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Abu-Asaker
authors.forename: Hildebert
authors.initials: H
authors.lastname: Wagner
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mirjolet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guilbaud
authors.forename: Marie-Aleth
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D031049:Eryngium / Q000737:chemistry*; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014421:Turkey
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes