title: Differentiating the effects of pharmacological and psychosocial interventions in an intensive rehabilitation programme.
abstract: BACKGROUND
  It is of clinical importance to identify the contribution of the individual components in a composite intervention, but this is difficult in practice. The aim of this study was to differentiate the effects of pharmacological and psychosocial interventions in improving the symptoms of patients with schizophrenia undergoing an intensive rehabilitation programme.
  
  
  METHODS
  The Krawiecka Goldberg Vaughn scale was used to record the symptoms of 19 long-stay inpatients in the rehabilitation programme. Ratings were made every 2 weeks for periods of between 1 year and 20 months.
  
  
  RESULTS
  Analysis of the time course of symptoms showed that substitution of a single novel antipsychotic for conventional antipsychotic regimes was followed by a significant reduction in delusions but no improvement in hallucinations or negative symptoms. However, hallucinations and negative symptoms reduced significantly over the whole period of the observations, indicating an effect of the composite psychosocial interventions in the programme.
  
  
  CONCLUSIONS
  For patients with persistent psychotic symptoms, changing from conventional to novel antipsychotic medication is likely to reduce delusions, whereas hallucinations and negative symptoms may be more responsive to a combination of psychosocial interventions.
authors.affiliation: Department of Mental Health Sciences, Royal Free and University College Medical School, London, UK. a.szmidla@medsch.ucl.ac.uk
authors.forename: Andrew
authors.initials: A
authors.lastname: Szmidla
authors.forename: Julian
authors.initials: J
authors.lastname: Leff
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D004358:Drug Therapy / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008605:Mental Health Services / Q000706:statistics & numerical data*; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy* / Q000534:rehabilitation* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents