Cerebral vasoreactivity is influenced by the prandial state among migraineurs.
OBJECTIVE
To test if the cerebral vasoreactivity among migraineurs is influenced by the prandial state.


METHODS
Eight patients with migraine without aura were studied (mean age = 23.75 years; range = 19 to 32 years; 6 women). We also studied 8 healthy controls (mean age = 20.63 years; range = 18 to 22 years; 3 women), with no history of migraine. Cerebral vasoreactivity was measured on the right side by the breath holding index (BHI) using an EZ-Dop transcranial Doppler instrument, with a 2-MHz transducer fitted on a headband. Serum glucose levels were measured after a 10-hour fasting period and then 10 minutes after a standardized breakfast.


RESULTS
In both groups, we found a postprandial (PP) glycemia enhancement (P < .02). Migraineurs showed enhanced PP cerebral vasoreactivity when compared to the fasting state (FS) (BHI-PP = 1.46; BHI-FS = 1.16; P= .02). Among controls, we found a trade to enhancement, but without statistic significance (BHI-PP = 1.28; BHI-FS = 1.11; P= .30). Glucose levels were not significantly correlated to cerebral vasoreactivity in any of the groups (P > .05).


CONCLUSIONS
Our findings suggest that migraineurs have a higher reactivity to hypercapnia during the PP period.
Coelho
Rodolfo de S
Rde S
Universidade Católica de Brasília, Brasilia, Distrito Federal, Brazil.
Gomes
Ciro M
CM
Teixeira
Ricardo A
RA
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005215:Fasting / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D020326:Migraine without Aura / Q000097:blood / Q000503:physiopathology*; D019518:Postprandial Period / Q000502:physiology*
D001786:Blood Glucose