Foxp3+ regulatory T cells in antiretroviral-naive HIV patients.
We characterized regulatory T cells from antiretroviral-naive HIV patients by flow cytometry. The proportion of CD4 cells positive for CD25 and Foxp3 was increased, mainly in those with CD4 cell counts less than 200 cells/microl. The total number of Foxp3-positive cells correlated with the CD4 cell count. Further studies are needed on whether Foxp3-positive cell numbers or function explain the susceptibility to autoimmune and inflammatory diseases seen in some patients with advanced HIV.
Montes
Martin
M
Department of Medicine, Texas, USA.
Lewis
Dorothy E
DE
Sanchez
Cesar
C
Lopez de Castilla
Diego
D
Graviss
Edward A
EA
Seas
Carlos
C
Gotuzzo
Eduardo
E
White
A Clinton
AC
D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D051858:Forkhead Transcription Factors / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors