title: Mysterious outbreaks of gastrointestinal illness associated with burritos supplied through school lunch programs.
abstract: From October 1997 through March 1998, three outbreaks of gastrointestinal illness among school children were linked to company A burritos. In September 1998, a similar outbreak occurred in three North Dakota schools following lunches that included company B burritos. We conducted an investigation to determine the source of the North Dakota outbreak, identify other similar outbreaks, characterize the illness, and gather evidence about the cause. The investigation included epidemiologic analyses, environmental investigation, and laboratory analyses. In North Dakota, a case was defined as nausea, headache, abdominal cramps, vomiting, or diarrhea after lunch on 16 September 1998. Case definitions varied in the other states. In North Dakota, 504 students and staff met the case definition; predominant symptoms were nausea (72%), headache (68%), abdominal cramps (54%), vomiting (24%), and diarrhea (16%). The median incubation period was 35 min and median duration of illness was 6 h. Eating burritos was significantly associated with illness (odds ratio, 2.6; 95% confidence interval, 1.6 to 4.2). We identified 16 outbreaks that occurred in seven states from October 1997 through October 1998, affecting more than 1,900 people who ate burritos from two unrelated companies. All tortillas were made with wheat flour, but the fillings differed, suggesting that tortillas contained the etiologic agent. Results of plant inspections, tracebacks, and laboratory investigations were unrevealing. More than two million pounds of burritos were recalled or held from distribution. The short incubation period, symptoms, and laboratory data suggest that these outbreaks were caused by an undetected toxin or an agent not previously associated with this clinical syndrome. Mass psychogenic illness is an unlikely explanation because of the large number of sites where outbreaks occurred over a short period, the similarity of symptoms, the common food item, the lack of publicity, and the link to only two companies. A network of laboratories that can rapidly identify known and screen for unknown agents in food is a critical part of protecting the food supply against natural and intentional contamination.
authors.affiliation: Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. ellen.stevenson@choa.org
authors.forename: Ellen B
authors.initials: EB
authors.lastname: Steinberg
authors.forename: Alden
authors.initials: A
authors.lastname: Henderson
authors.forename: Adam
authors.initials: A
authors.lastname: Karpati
authors.forename: Mike
authors.initials: M
authors.lastname: Hoekstra
authors.forename: Nina
authors.initials: N
authors.lastname: Marano
authors.forename: Jennifer Martinelli
authors.initials: JM
authors.lastname: Souza
authors.forename: Meg
authors.initials: M
authors.lastname: Simons
authors.forename: Kirby
authors.initials: K
authors.lastname: Kruger
authors.forename: Jennifer
authors.initials: J
authors.lastname: Giroux
authors.forename: Helen S
authors.initials: HS
authors.lastname: Rogers
authors.forename: Michael K
authors.initials: MK
authors.lastname: Hoffman
authors.forename: Abdel-Razak M
authors.initials: AR
authors.lastname: Kadry
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Griffin
mesh_terms: D002648:Child; D015331:Cohort Studies; D004196:Disease Outbreaks; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D005516:Food Microbiology; D005522:Food Services; D005759:Gastroenteritis / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009658:North Dakota / Q000453:epidemiology; D016017:Odds Ratio; D012189:Retrospective Studies; D012574:Schools