title: Interleukin-1 gene complex in schizophrenia: an association study.
abstract: The aim of this study is to investigate the association between three polymorphisms of the interleukin-1 (IL-1) gene complex and schizophrenia. We genotyped 228 outpatients with schizophrenia (DSM-IV criteria) and 419 unrelated healthy controls. The following polymorphisms were analyzed: IL-1alpha -889 C/T, IL-1beta +3953 C/T, and IL-1RA (86 bp)n. No significant differences in genotype or in allelic distribution of the Il-1alpha, IL-1beta, and IL-1RA polymorphisms were found. Estimated haplotype frequencies were similar in both groups. Our data do not suggest that genetically determined changes in the IL-1 gene complex confer increased susceptibility for schizophrenia.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Oviedo, Oviedo, Spain. frank@uniovi.es
authors.forename: Pilar A
authors.initials: PA
authors.lastname: Saiz
authors.forename: Maria P
authors.initials: MP
authors.lastname: Garcia-Portilla
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Blanca
authors.initials: B
authors.lastname: Morales
authors.forename: Sara
authors.initials: S
authors.lastname: Martinez-Barrondo
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: Juan
authors.initials: J
authors.lastname: Fernandez
authors.forename: Manuel
authors.initials: M
authors.lastname: Bousono
authors.forename: Julio
authors.initials: J
authors.lastname: Bobes
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D007375:Interleukin-1