Meta-analysis of frusemide to prevent or treat acute renal failure.
OBJECTIVE
To investigate the potential beneficial and adverse effects of frusemide to prevent or treat acute renal failure in adults.


METHODS
Meta-analysis of randomised controlled trials.


METHODS
Cochrane controlled trials register (2005 issue 4), Embase, and Medline (1966 to 1 February 2006), without language restrictions.


METHODS
Two reviewers checked the quality of the studies and independently extracted data.


RESULTS
Nine randomised controlled trials totalling 849 patients with or at risk of acute renal failure were included. Outcome measures not significantly different after frusemide treatment were in-hospital mortality (relative risk 1.11, 95% confidence interval 0.92 to 1.33), risk for requiring renal replacement therapy or dialysis (0.99, 0.80 to 1.22), number of dialysis sessions required (weight mean difference--0.48 sessions, -1.45 to 0.50), and proportion of patients with persistent oliguria (urine output < 500 ml/day: 0.54, 0.18 to 1.61). Stratifying studies that used frusemide to prevent or treat acute renal failure did not change the results on mortality (relative risk ratio 2.10, 95% confidence interval 0.67 to 6.63) and the risk for requiring dialysis (4.12, 0.46 to 37.2). Evidence suggested an increased risk of temporary deafness and tinnitus in patients treated with high doses of frusemide (relative risk 3.97, 95% confidence interval 1.00 to 15.78).


CONCLUSIONS
Frusemide is not associated with any significant clinical benefits in the prevention and treatment of acute renal failure in adults. High doses may be associated with an increased risk of ototoxicity.
Ho
Kwok M
KM
Intensive Care Unit, Royal Perth Hospital, Perth, Western Australia 6000. kwok.ho@health.wa.gov.au
Sheridan
David J
DJ
D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000517:prevention & control; D000328:Adult; D004232:Diuretics / Q000627:therapeutic use*; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic
D004232:Diuretics; D005665:Furosemide