title: Early pancreas transplant outcomes with histidine-tryptophan-ketoglutarate preservation: a multicenter study.
abstract: Little is known about the use of histidine-tryptophan-ketoglutarate (HTK) preservation solution for pancreas preservation. We compared early pancreas graft outcomes at four pancreas transplant programs within the state of Michigan in 2002 and 2003 (University of Wisconsin [UW] era) with those in 2004 (HTK era). The primary endpoint was early graft loss. The UW group (n=41) and the HTK group (n=36) had similar outcomes with respect to: technical graft loss (9.8% vs. 8.3%, P=NS), 90-day graft function (90.2% vs. 86.1%, P=NS), and rate of pancreatic leak/abscess (12.2% vs. 11.1%, P=NS). There were also no significant differences in postoperative amylase and lipase levels between the two groups. The HTK group did have significantly more acute rejection within the first 180 days (25.0% vs. 9.8%, P<0.05). HTK is a suitable substitute for UW in the preservation of pancreas allografts.
authors.affiliation: Division of Transplantation, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109-0331, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Englesbe
authors.forename: Alice
authors.initials: A
authors.lastname: Moyer
authors.forename: Dean Y
authors.initials: DY
authors.lastname: Kim
authors.forename: Darla K
authors.initials: DK
authors.lastname: Granger
authors.forename: Richard
authors.initials: R
authors.lastname: Pietroski
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshida
authors.forename: Juan D
authors.initials: JD
authors.lastname: Arenas
authors.forename: Henry
authors.initials: H
authors.lastname: Oh
authors.forename: Shawn J
authors.initials: SJ
authors.lastname: Pelletier
authors.forename: Darrell A
authors.initials: DA
authors.lastname: Campbell
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Punch
authors.forename: John C
authors.initials: JC
authors.lastname: Magee
authors.forename: Scott A
authors.initials: SA
authors.lastname: Gruber
authors.forename: Randall S
authors.initials: RS
authors.lastname: Sung
mesh_terms: D000328:Adult; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects*; D016035:Pancreas Transplantation; D011189:Potassium Chloride / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology
chemical_list: C039984:Bretschneider cardioplegic solution; D019188:Organ Preservation Solutions; D008353:Mannitol; D011343:Procaine; D011189:Potassium Chloride; D005947:Glucose