title: Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma.
abstract: We report two cases of eccrine porocarcinoma (EPC), one of intrepidermal EPC (IEEPC) and one of intradermal invasive EPC (IDEPC) in an immunohistochemical study of cytokeratins (CK) using nine different anti-keratin antibodies against CK1, 7, 8, 10, 14, 16, 17, 18 and 19. IEEPC expressed terminal differentiated CK1 and CK10. In contrast, IDEPC expressed simple-epithelial keratins such as CK7, 8, 18 and 19. Keratin expression of IEEPC preserves the immunophenotypes of normal epidermis. IDEPC, however, expresses poorly differentiated keratin. These results suggest that the keratin profiles of EPC are correlated with the invasive degree and reflect the clinical prognosis of EPC.
authors.affiliation: Department of Dermatology, Mie University Graduate School of Medicine, Mie 514-8507, Japan. kuroichi@clin.medic.mie-u.ac.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurokawa
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Urakawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Senba
authors.forename: Eriko
authors.initials: E
authors.lastname: Kawabata
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nishimura
authors.forename: Youichi
authors.initials: Y
authors.lastname: Omoto
authors.forename: Kazuya
authors.initials: K
authors.lastname: Tokime
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mizutani
authors.forename: Airo
authors.initials: A
authors.lastname: Tsubura
mesh_terms: D018250:Acrospiroma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D004439:Eccrine Glands / Q000378:metabolism* / Q000473:pathology; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D007633:Keratins