Kidney disease in antiphospholipid syndrome.
Renal involvement is a frequent finding in patients with APS. All vascular structures of the kidney may be affected, leading to diverse clinical con-sequences including severe hypertension, proteinuria, hematuria, nephrotic syndrome, and renal failure. In some instances ESRD may occur. Unfortunately, APS patients are at high risk of posttransplant renal thrombosis. The nephropathy of APS is characterized by TMA, FIH, and FCA. The nephropathy of APS should be included in the APS classification criteria. Prospective studies to evaluate management of the diverse renal compromise in APS patients are urgently needed.
Amigo
Mary-Carmen
MC
Universidad Nacional Autónoma de México, Department of Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Distrito Federal, Tlalpan, Mexico 14080, Mexico. marycarmenamigo@gmail.com
D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D001284:Atrophy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006965:Hyperplasia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D007672:Kidney Cortex / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008833:Microcirculation / Q000503:physiopathology; D013927:Thrombosis / Q000209:etiology / Q000473:pathology; D017539:Tunica Intima / Q000473:pathology