title: Trypanocidal constituents in plants 6. 1) Minor withanolides from the aerial parts of Physalis angulata.
abstract: Further study of the methanol extract of the aerial parts of Physalis angulata (Solanaceae) resulted in the isolation of new withanolides, designated physagulins L, M and N, together with known withanolide, physagulin D and flavonol glycoside, quercetin 3-O-rhamnosyl-(1-->6)-galactoside. The chemical structures of these new withanolides were elucidated by detailed spectroscopic analyses to be (20R,22R)-15alpha-acetoxy-5alpha,6beta,14beta,17beta,27-pentahydroxy-1-oxo-witha-2, 24-dienolide, (20S,22S)-15alpha-acetoxy-5alpha,6beta,14alpha,23beta-tetrahydroxy-1-oxo-witha-2,16,24-trienolide and (20S,22R)-15alpha-acetoxy-5beta,6beta-epoxy-14alpha-hydoxy-3beta-methoxy-1-oxo-witha-16,24-dienolide, respectively. All these compounds showed weak trypanocidal activity against trypomastigotes, an infectious form of Trypanosoma cruzi, the etiologic agent for Chagas' disease. Withanolides obtained in the previous paper showed considerable trypanocidal activity, suggesting the structure-activity relationships.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. abefumi@fukuoka-u.ac.jp
authors.forename: Fumiko
authors.initials: F
authors.lastname: Abe
authors.forename: Shinya
authors.initials: S
authors.lastname: Nagafuji
authors.forename: Masafumi
authors.initials: M
authors.lastname: Okawa
authors.forename: Junei
authors.initials: J
authors.lastname: Kinjo
mesh_terms: D000818:Animals; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D032321:Physalis / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry*; D028321:Plant Preparations / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D028321:Plant Preparations; D014344:Trypanocidal Agents; D004875:Ergosterol