Liver biopsy interpretation for causes of late liver allograft dysfunction.
Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury. In an attempt to enable centers to compare and pool results, improve therapy, and better understand pathophysiological disease mechanisms, the Banff Working Group on Liver Allograft Pathology herein proposes a set of consensus criteria for the most common and problematic causes of late liver allograft dysfunction, including late-onset acute and chronic rejection, recurrent and new-onset viral and autoimmune hepatitis, biliary strictures, and recurrent primary biliary cirrhosis and primary sclerosing cholangitis. A discussion of differential diagnosis is also presented.
Demetris
Anthony J
AJ
Adeyi
Oyedele
O
Bellamy
Chris O C
CO
Clouston
Andrew
A
Charlotte
Frederic
F
Czaja
Albert
A
Daskal
Ierachmiel
I
El-Monayeri
Magda S
MS
Fontes
Paulo
P
Fung
John
J
Gridelli
Bruno
B
Guido
Maria
M
Haga
Hironori
H
Hart
John
J
Honsova
Eva
E
Hubscher
Stefan
S
Itoh
Tomoo
T
Jhala
Nirag
N
Jungmann
Patricia
P
Khettry
Urmila
U
Lassman
Charles
C
Ligato
Saverio
S
Lunz
John G
JG
Marcos
Amadeo
A
Minervini
Marta Ida
MI
Mölne
Johan
J
Nalesnik
Mike
M
Nasser
Imad
I
Neil
Desley
D
Ochoa
Erin
E
Pappo
Orit
O
Randhawa
Parmjeet
P
Reinholt
Finn P
FP
Ruiz
Phil
P
Sebagh
Mylène
M
Spada
Marco
M
Sonzogni
Aurelio
A
Tsamandas
Athanassios C
AC
Wernerson
Annika
A
Wu
Tong
T
Yilmaz
Funda
F
D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation / Q000473:pathology*; D013997:Time Factors; D014184:Transplantation, Homologous