Visuospatial processing and the function of prefrontal-parietal networks in autism spectrum disorders: a functional MRI study.
OBJECTIVE
Individuals with autism spectrum disorders typically have normal visuospatial abilities but impaired executive functioning, particularly in abilities related to working memory and attention. The aim of this study was to elucidate the functioning of frontoparietal networks underlying spatial working memory processes during mental rotation in persons with autism spectrum disorders.


METHODS
Seven adolescent males with normal IQ with an autism spectrum disorder and nine age- and IQ-matched male comparison subjects underwent functional magnetic resonance imaging scans while performing a mental rotation task.


RESULTS
The autism spectrum disorders group showed less activation in lateral and medial premotor cortex, dorsolateral prefrontal cortex, anterior cingulate gyrus, and caudate nucleus.


CONCLUSIONS
The finding of less activation in prefrontal regions but not in parietal regions supports a model of dysfunction of frontostriatal networks in autism spectrum disorders.
Silk
Timothy J
TJ
Howard Florey Institute, University of Melbourne, Victoria 3010, Australia.
Rinehart
Nicole
N
Bradshaw
John L
JL
Tonge
Bruce
B
Egan
Gary
G
O'Boyle
Michael W
MW
Cunnington
Ross
R
D000293:Adolescent; D001321:Autistic Disorder / Q000175:diagnosis* / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000502:physiology*; D013647:Task Performance and Analysis