title: Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia.
abstract: Subtle variation in the expression or function of a small group of transcription factors can drive leukemogenesis. The CEBPA protein is known to regulate the balance between cell proliferation and differentiation during early hematopoietic development and myeloid differentiation. In human myeloid leukemia, CEBPA is frequently inactivated by mutation and indirect and posttranslational mechanisms, in keeping with tumor suppressor properties. We report that CEBPA is activated by juxtaposition to the immunoglobulin gene enhancer upon its rearrangement with the immunoglobulin heavy-chain locus in precursor B-cell acute lymphoblastic leukemia harboring t(14;19)(q32;q13). Overexpression of apparently normal CEBPA RNA or protein was observed in 6 patients. These data indicate that CEBPA may exhibit oncogenic as well as tumor suppressor properties in human leukemogenesis.
authors.affiliation: Assistance Publique-Hôpitaux de Paris (AP-HP) Service d'Hématologie Biologique, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Chapiro
authors.forename: Lisa
authors.initials: L
authors.lastname: Russell
authors.forename: Isabelle
authors.initials: I
authors.lastname: Radford-Weiss
authors.forename: Christian
authors.initials: C
authors.lastname: Bastard
authors.forename: Michel
authors.initials: M
authors.lastname: Lessard
authors.forename: Stephanie
authors.initials: S
authors.lastname: Struski
authors.forename: Helene
authors.initials: H
authors.lastname: Cave
authors.forename: Sandra
authors.initials: S
authors.lastname: Fert-Ferrer
authors.forename: Carole
authors.initials: C
authors.lastname: Barin
authors.forename: Odile
authors.initials: O
authors.lastname: Maarek
authors.forename: Veronique
authors.initials: V
authors.lastname: Della-Valle
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Strefford
authors.forename: Roland
authors.initials: R
authors.lastname: Berger
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Harrison
authors.forename: Olivier A
authors.initials: OA
authors.lastname: Bernard
authors.forename: Florence
authors.initials: F
authors.lastname: Nguyen-Khac
mesh_terms: D000328:Adult; D000368:Aged; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D002648:Child; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*; D012334:RNA, Neoplasm / Q000032:analysis; D014178:Translocation, Genetic
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; D007143:Immunoglobulin Heavy Chains; D012334:RNA, Neoplasm