Protective effect of lutein on ischemia-reperfusion injury in rat small intestine.
Lutein is a carotenoid and it has antioxidant effects. Lutein may have a protective effect on ischemia reperfusion (I/R) injury induced by free radical species. However, little is known about the protective effect of lutein on I/R injury in vivo. The present study was undertaken to clarify the protective effects of lutein on I/R injuries in the rat small intestine. Administration of lutein before intestinal I/R attenuated the damage to villi and deciduation of enterocytes and suppressed the increase in lipid peroxide.
Ogura
Wakako
W
Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan.
Itagaki
Shirou
S
Kurokawa
Toshimitsu
T
Noda
Toshihiro
T
Hirano
Takeshi
T
Mizuno
Satoshi
S
Iseki
Ken
K
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005609:Free Radicals; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology; D014975:Lutein / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*
D000975:Antioxidants; D005609:Free Radicals; D014975:Lutein