title: Bafoudiosbulbins A, and B, two anti-salmonellal clerodane diterpenoids from Dioscorea bulbifera L. var sativa.
abstract: Two clerodane diterpenoids, Bafoudiosbulbins A 1, and B 2, together with five known compounds: tetracosanoic acid, 1-(tetracosanoyl)-glycerol, trans-tetracosanylferulate, beta-sitosterol and 3-O-beta-D-glucopyranosyl-beta-sitosterol were isolated from the tubers of Dioscorea bulbifera L. var sativa. Their structures were established by spectroscopic methods (1D and 2D-NMR, MS) and X-ray crystallographic diffraction analysis of compound 1. The CH2Cl2-soluble portion of the crude extract and the two clerodanes were screened for anti-bacterial activity using both agar diffusion and broth dilution techniques against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi A and Salmonella paratyphi B. They both showed significant activities against P. aeruginosa, S. typhi, S. paratyphi A and S. paratyphi B.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
authors.forename: Rémy Bertrand
authors.initials: RB
authors.lastname: Teponno
authors.forename: Azefack Léon
authors.initials: AL
authors.lastname: Tapondjou
authors.forename: Donatien
authors.initials: D
authors.lastname: Gatsing
authors.forename: Jules Désiré
authors.initials: JD
authors.lastname: Djoukeng
authors.forename: Eliane
authors.initials: E
authors.lastname: Abou-Mansour
authors.forename: Raphael
authors.initials: R
authors.lastname: Tabacchi
authors.forename: Pierre
authors.initials: P
authors.lastname: Tane
authors.forename: H
authors.initials: H
authors.lastname: Stoekli-Evans
authors.forename: David
authors.initials: D
authors.lastname: Lontsi
mesh_terms: D001419:Bacteria / Q000187:drug effects; D027742:Dioscorea / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008826:Microbial Sensitivity Tests / Q000379:methods; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012485:Salmonella typhi / Q000187:drug effects*; D014961:X-Ray Diffraction
chemical_list: D004224:Diterpenes; D045785:Diterpenes, Clerodane; D005227:Fatty Acids; D010936:Plant Extracts; C010210:lignoceric acid