Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings.
A novel conjugate of 3-Clip-Phen and polyamide containing three N-methylimidazole (Im) rings was synthesized for the targeting human telomeric repeat of 5'-TTAGGG-3', and the DNA cleaving activity and the sequence selectivity of the complex of copper-conjugate were confirmed by electrospray ionization mass spectrometry.
Liu
Dan
D
Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Zhou
Jiang
J
Li
Huihui
H
Zheng
Bo
B
Yuan
Gu
G
D001665:Binding Sites; D002614:Chelating Agents / Q000737:chemistry; D003300:Copper; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects*; D016503:Drug Delivery Systems; D015195:Drug Design; D007093:Imidazoles / Q000737:chemistry; D009757:Nylons / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D012091:Repetitive Sequences, Nucleic Acid / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D016615:Telomere / Q000737:chemistry / Q000187:drug effects
D002614:Chelating Agents; D007093:Imidazoles; D009757:Nylons; D009942:Organometallic Compounds; D003300:Copper; D004247:DNA; C018100:1-methylimidazole