Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae).
Five cadinane sesquiterpenes derivatives were isolated by bioassay-guided fractionation from Phomopis cassiae, an endophytic fungus isolated from Cassia spectabilis. The structures of the two diastereoisomeric 3,9,12-trihydroxycalamenenes (1, 2); 3,12-dihydroxycalamenene (3); 3,12-dihydroxycadalene (4) and 3,11,12-trihydroxycadalene (5) were established on the basis of analyses of 1D and 2D NMR and HRTOFMS experiments. Antifungal activity of the isolates was evaluated against Cladosporium sphaerospermum and Cladosporium cladosporioides, revealing 5 as the most active compound.
Silva
Geraldo Humberto
GH
NuBBE-Núcleo de Bioensaio, Biossíntese e Ecofisiologia de Produtos Naturais, Instituto de Química, Universidade Estadual Paulista, CP 355, CEP 14801-970, Araraquara, SP, Brazil.
Teles
Helder Lopes
HL
Zanardi
Lisinéia Maria
LM
Marx Young
Maria Claudia
MC
Eberlin
Marcos Nogueira
MN
Hadad
Renato
R
Pfenning
Ludwig H
LH
Costa-Neto
Claudio Miguel
CM
Castro-Gamboa
Ian
I
da Silva Bolzani
Vanderlan
V
Araújo
Angela Regina
AR
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D002366:Cassia / Q000382:microbiology*; D002470:Cell Survival / Q000187:drug effects; D002963:Cladosporium / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C508039:cadinane