title: Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India.
abstract: BACKGROUND
  Factor V Leiden has been reported in 2%-30% of patients with portal vein thrombosis. This wide variation makes it difficult to assess the importance of factor V Leiden as a predisposing factor.
  
  
  METHODS
  Factor V Leiden was determined by restriction fragment length polymorphism in 112 patients with portal vein thrombosis, 104 with deep vein thrombosis and 98 control subjects.
  
  
  RESULTS
  Only 3/112 (3%) patients with portal vein thrombosis had factor V Leiden, compared to 1/98 (1%) controls and 16/104 (15%) with deep vein thrombosis; of these, 3, 1 and 15, respectively, were heterozygous for this mutation.
  
  
  CONCLUSIONS
  Factor V Leiden contributes little, if at all, to the development of portal vein thrombosis in southern India.
authors.affiliation: Department of Gastroenterology and Molecular Biology Unit, Institute of Population Health and Clinical Research, St. John's Medical College Hospital, Bangalore - 560 034, India. koshyabe@yahoo.com
authors.forename: Abraham
authors.initials: A
authors.lastname: Koshy
authors.forename: Mary
authors.initials: M
authors.lastname: Jeyakumari
mesh_terms: D020016:Activated Protein C Resistance / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D008642:Mesenteric Veins / Q000473:pathology; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011169:Portal Vein / Q000473:pathology*; D013162:Splenic Vein / Q000473:pathology; D020246:Venous Thrombosis / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V