Cytochrome P450s and cholesterol homeostasis.
By participating in pathways of cholesterol biosynthesis and elimination, different cytochrome P450 (P450 or CYP) enzymes play an important role in maintenance of cholesterol homeostasis. CYP51 is involved in cholesterol biosynthesis, whereas CYP 7A1, 27A1, 46A1, 7B1, 39A1, and 8B1 are the key enzymes in cholesterol catabolism to bile acids, the major route of cholesterol elimination in mammals. Cholesterol transformations to steroid hormones are also initiated by the P450 enzyme CYP11A1. Finally, one of the major drug-metabolizing P450s CYP3A4 seems to contribute to bile acid biosynthesis as well. The 9 P450s will be the focus of this review and assessed as drug targets for cholesterol lowering.
Pikuleva
Irina A
IA
Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1031, USA. irpikule@utmb.edu
D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000502:physiology; D013256:Steroids / Q000096:biosynthesis
D001647:Bile Acids and Salts; D007527:Isoenzymes; D013256:Steroids; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol