Cytotoxic arylnaphthalene lignans from Phyllanthus oligospermus.
Three new arylnaphthalene lignans, namely phyllanthusmins A-C, together with nine known compounds were isolated and characterized from the stems and roots of Phyllanthus oligospermus by a bioassay-guided purification. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Among them, phyllanthusminA displayed significant cytotoxicity against KB and P-388 cancer cell lines.
Wu
Shwu-Jen
SJ
Department of Medical Technology, Chung Hwa College of Medical Technology, Tainan Hsien 717, Taiwan. shwu01054@yahoo.com.tw
Wu
Tian-Shung
TS
D052117:Benzodioxoles / Q000737:chemistry* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D029803:Phyllanthus / Q000737:chemistry*; D028321:Plant Preparations / Q000737:chemistry; D013057:Spectrum Analysis
D052117:Benzodioxoles; D001572:Benzofurans; D006027:Glycosides; D017705:Lignans; D009281:Naphthalenes; D028321:Plant Preparations; C514007:phyllanthusmin A; C514008:phyllanthusmin B; C514009:phyllanthusmin C