Vaginal microbicides can interfere with nucleic acid amplification tests used for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae infection.
We confirmed findings from previous studies that cellulose sulfate gel can interfere with nucleic acid amplification tests used for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae. We therefore recommend that the effects of microbicide gels on diagnostic assays of sexually transmitted infections be established before starting up clinical studies.
Crucitti
Tania
T
HIV/STD Research and Intervention Unit, Institute of Tropical Medicine,155 Nationalestraat, 2000 Antwerp, Belgium. tcrucitti@itg.be
Jespers
Vicky
V
Van Damme
Lut
L
Van Dyck
Eddy
E
Buvé
Anne
A
D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000382:microbiology / Q000517:prevention & control; D002692:Chlamydia trachomatis / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005782:Gels; D006069:Gonorrhea / Q000175:diagnosis* / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000302:isolation & purification; D021141:Nucleic Acid Amplification Techniques / Q000592:standards; D013048:Specimen Handling / Q000379:methods; D014621:Vagina / Q000737:chemistry* / Q000382:microbiology
D005782:Gels; D002482:Cellulose; C020254:cellulose sulfate