Analysis of a complex analgesic formulation by high-performance liquid chromatography with column-switching.
An isocratic method is described which allows the complete separation of acetylsalicylic acid, paracetamol, caffeine, carbromal, bromisoval and codeine as well as the potential impurities salicylic acid, diacetyl-p-aminophenol and acetylcodeine. A column-switching technique was developed employing two columns (10 cm and 25 cm) containing 7-microm Zorbax C(8) material. The separation is better and faster than that obtained with a gradient elution method.
Cockaerts
P
P
Katholieke Universiteit Leuven, Instituut voor Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie, Van Evenstraat 4, B-3000 Leuven, Belgium.
Roets
E
E
Hoogmartens
J
J