[Place of anatomopathology in evaluation of response to neoadjuvant chemotherapy. Prognostic and predictive markers: example of breast cancer].
The pathologist plays a key role in the optimal management of patients receiving an induction or a neoadjuvant chemotherapy. The evaluation of the pre-treatment biopsy helps to establish key patient-management parameters such as tumor type, SBR grade and immunohistochemical parameters. This evaluation provides predictive parameters with regards to drug response such as hormonal status, proliferation factors and overexpression of Her-2. The evaluation of the post-treatment tumour residue helps to determine tumour response to treatment and prognosis, as well as to adjust adjuvant regimens. It is essential to standardize these histopathological procedures.
Abrial
Catherine
C
Unité de recherche clinique, Centre Jean-Perrin, 58, rue Montalembert, BP392, 63011 Clermont-Ferrand Cedex 1. recherche.clinique@cjp.fr
Bouchet-Mishellany
Florence
F
Raoelfils
Inès
I
Cayre
Anne
A
Curé
Hervé
H
Chollet
Philippe
P
Penault-Llorca
Frédérique
F
D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D011379:Prognosis; D012074:Remission Induction
D014408:Biomarkers, Tumor