title: Could melatonin unbalance the equilibrium between autophagy and invasive processes?
abstract: The Syrian hamster Harderian gland (HG) is a juxtaorbital organ exhibiting marked gender-associated morphological differences. Regarding contents of porphyrins, this gland is a good model for studying physiological oxidative stress effects, since both sexes present strong (in females) and moderate (in males) levels of this stress in normal conditions. We have recently showed that autophagic processes are in the Syrian hamster HG as the first result of an elevated porphyrin metabolism observed in both sexes. In this case, autophagy is not a cell death mechanism per se but a constant renovation system which allows to continuing with the normal gland activity. Moreover, we have also reported that this gland presents invasive processes, resembling to tumoral progression, and are, additionally, a consequence of a strong oxidative stress environment that is mainly observed in female Syrian hamster HG and in minor proportion in male HG. Here, we present additional data and discuss a model of melatonin action on these cited processes by which melatonin would be able to destroy the equilibrium between both detoxifying actions. We postulate that melatonin reduces oxidative stress level into HG as direct antioxidant. This decrease of free radicals produces the autophagy inhibition due to outbreak signal disappearance in HG. Under these events and regarding the huge contents of porphyrins that this gland supports, the invasive process triggers.
authors.affiliation: Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain. acoto@@uniovi.es
authors.forename: Ana
authors.initials: A
authors.lastname: Coto-Montes
authors.forename: Cristina
authors.initials: C
authors.lastname: Tomás-Zapico
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001343:Autophagy; D002402:Cathepsin D / Q000502:physiology; D002465:Cell Movement; D006224:Cricetinae; D005260:Female; D006243:Harderian Gland / Q000166:cytology*; D008297:Male; D008550:Melatonin / Q000502:physiology*; D018384:Oxidative Stress; D012737:Sex Factors
chemical_list: D000975:Antioxidants; D002402:Cathepsin D; D008550:Melatonin