Cell-type-specific regulation of RNA polymerase I transcription: a new frontier.
Ribosomal RNA transcription was one of the first model systems for molecular characterization of a transcription regulatory mechanism and certainly one of the best studied in the widest range of organisms. In multicellular organisms, however, the issue of cell-type-specific regulation of rRNA transcription has not been well addressed. Here I propose that a systematic study of cell-type-specific regulation of rRNA transcription may reveal new regulatory mechanisms that have not been previously realized. Specifically, issues concerning the cell-type-specific requirement for rRNA production, the universality of Pol I transcription complex and the division of rDNA into regulatory subdomains are discussed.
Tseng
Hung
H
Department of Dermatology, Department of Cell and Developmental Biology, Center for Research on Reproduction and Women's Health, University of Pennsylvania, CRB Room 242B, 415 Curie Boulevard, Philadelphia, PA 19104, USA. htsengpe@mail.med.upenn.edu
D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000145:classification / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family / Q000235:genetics; D012318:RNA Polymerase I / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics*
D007527:Isoenzymes; D012335:RNA, Ribosomal; D014157:Transcription Factors; D012318:RNA Polymerase I