title: FDA signals it's open to drug trials that shift midcourse.
authors.forename: Anna Wilde
authors.initials: AW
authors.lastname: Mathews
mesh_terms: D026661:Clinical Trials Data Monitoring Committees; D002986:Clinical Trials as Topic / Q000941:ethics / Q000331:legislation & jurisprudence / Q000379:methods*; D003627:Data Interpretation, Statistical; D004341:Drug Evaluation / Q000379:methods; D004345:Drug Industry; D006801:Humans; D012107:Research Design; D018401:Sample Size; D014481:United States; D014486:United States Food and Drug Administration