NMR spectroscopy: analytical applications from chemistry to the clinic.
The impact of new technology in NMR instrumentation is described with reference to a range of problem areas in the pharmaceutical and biomedical fields. In particular, the contribution of very high field instruments based on superconducting magnets is considered, together with Fourier transform and related software developments. Specific application areas discussed include quantitative analysis, structure elucidation, NMR detection in high-performance liquid chromatography, analysis of body fluids, metabolic studies in single cells, analysis of intact tissue in vitro and in vivo, and NMR imaging.
Lindon
J C
JC
Department of Physical Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, UK.