Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features.
We investigate the clinical association of tumor necrosis factor receptor 2 (TNFR2) M196R polymorphism with rheumatoid arthritis (RA) and knee osteoarthritis (OA). Acute phase reactants, lipid profile, sTNFR2 levels, disease activity-disability indexes, and TNFR2 M196R polymorphism were analyzed in 50 RA, 50 knee OA patients, and 120 healthy subjects (HS). The M/M genotype frequency was 0.74 (RA), 0.80 (OA), and 0.64 (HS). The M/R genotype frequency was RA (0.26), OA (0.20), and HS (0.29). The R/R genotype was observed only in HS (0.07). The M allele was associated with OA (P = 0.0137, OR = 2.43). Total cholesterol, triglyceride levels, apolipoprotein A-I and B showed significant differences (P < 0.05). The highest sTNFR2 levels were observed in RA and OA (P = 0.001), however M/M and M/R carriers do not correlate with sTNFR2 production. Our findings suggest an association of the M allele with knee OA. In addition, high sTNFR2 levels in RA and OA were found.
Oregón-Romero
Edith
E
Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Vázquez-Del Mercado
Mónica
M
Navarro-Hernández
Rosa Elena
RE
Torres-Carrillo
Norma
N
Martínez-Bonilla
Gloria
G
Estrada-García
Iris
I
Rangel-Villalobos
Héctor
H
Muñoz-Valle
José Francisco
JF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000235:genetics*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D004185:Disability Evaluation; D005838:Genotype; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000235:genetics*; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D047889:Receptors, Tumor Necrosis Factor, Type II; D014280:Triglycerides; D002784:Cholesterol