Use of nonsteroidal anti-inflammatory drugs and risk of oral cancer: a cohort study.
Epidemiologic data regarding the chemopreventive potential of nonsteroidal anti-inflammatory drugs (NSAIDs) against oral cancer are sparse. We found a relative risk for oral cancer of 1.2 (95% CI, 1.0-1.6) among 169,589 Danish NSAID users (> or =2 prescriptions), with no apparent trends in subgroups. Our study provided no clear evidence that NSAIDs may protect against oral cancer.
Friis
S
S
Institute of Cancer Epidemiology, Department of Genetics and Medicine, Danish Cancer Society, DK-2100 Copenhagen, Denmark. friis@cancer.dk
Poulsen
A
A
Pedersen
L
L
Baron
J A
JA
Sørensen
H T
HT
D000293:Adolescent; D017677:Age Distribution; D000367:Age Factors; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005500:Follow-Up Studies; D005783:Gender Identity; D006801:Humans; D015994:Incidence; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D012042:Registries; D012307:Risk Factors; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal