Computer-aided spectrophotometric determination of multicomponent drugs.
The conditions of least squares deconvolution by linear combination have been investigated in three-component systems. The significant effects of the main factors, the lack of significant interactions and the linear relationship of absorbance with the concentration of each component were established by using a 2(3) factorial experiment design and by evaluating the results with a three-way analysis of variance. The content of active ingredients of three-component injections was determined by means of computer-aided evaluation of UV-spectra in systems that fulfilled these conditions.
Géher
J
J
CHINOIN Pharmaceutical and Chemical Works Ltd., Budapest, Hungary.
Szabó
E
E