[Circulating proteinic biomarkers and breast cancer].
Circulating proteinic biomarkers are secreted by tumor cells or by their environmental cells and they have a variable specificity. In case of breast cancer, carcino-embryonic antigen (CEA) was for a long time the only circulating biomarker used. Nowadays, the most useful biomarkers measure circulating levels of fragments of MUC1-polymorphic epithelial mucin (MUC1-PEM): cancer antigen (CA) 15.3, mucin-like carcinoma-associated antigen (MCA), CA 27-29, CA 549... They are useful for general disease follow-up. Other circulating markers belonging to keratins (tissue polypeptide antigen, TPA, TPS or Cyfra 21.1) are correlated with proliferative activity of breast tumors. More recently, the measure of the c-erb B2 circulating part (extra cellular domain, ECD) was proposed as a prognostic biomarker for breast tumors with c-erb B2 overexpression. Moreover, the determination of urinary level of trefoil factor1 (PS2-TFF1) might be useful for the follow-up of hormonodependent breast cancers. The present review describes the clinical interest of these different circulating biomarkers in case of breast cancer, emphasizing their biological characteristics.
Mathelin
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Service de gynécologie-obstétrique, CHRU de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. carole.mathelin@chru-strasbourg.fr
Koehl
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Rio
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MC
D000951:Antigens, Neoplasm / Q000097:blood; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D007633:Keratins / Q000097:blood; D018396:Mucin-1 / Q000097:blood; D009077:Mucins / Q000097:blood; D009363:Neoplasm Proteins / Q000097:blood*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins / Q000652:urine
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D006023:Glycoproteins; D007633:Keratins; D018396:Mucin-1; D009077:Mucins; D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; C090797:CA 27-29 antigen; C072700:CA549 glycoprotein, human; C060192:MUC1 protein, human; C051838:TFF1 protein, human; C057387:mucinous carcinoma-associated antigen