[Research of modified rat laryngeal transplantation model].
OBJECTIVE
To study modified rat laryngeal transplantation model.


METHODS
Eighty isogeneic histocompatible F344 rats were randomized into control and experimental groups. Strome model of laryngeal transplantation was established in the the control group, and in the experimental group, the ascending pharyngeal artery was preserved and the base of the tongue, larynx and pharyngolarynx were harvested as a complex allograft followed by end-to-end anastomosis of the both allograft common carotid arteries with the recipient common carotid artery and the anterior jugular vein, respectively. The arterial and nenous patency rate and allograft viability rate were compared between the two groups.


RESULTS
The artery and vein patency rates and graft survival rate were 30%, 15%, and 30% in the control group, and 75%, 65%, and 80% in the experimental group, respectively, showing significant difference between the two groups (P<0.05).


CONCLUSIONS
In modified rat laryngeal transplantation model, the allograft viability rate and vessel patency rate are improved, which provides a good model for immunological study of larynx transplantation.
Li
Hao
H
State Key Laboratory of Oncology in Southern China, Department of Head and Neck, Oncology Center, Sun Yat-sen University, Guangzhou 510060, China.
Peng
Han-wei
HW
Zeng
Zong-yuan
ZY
Guo
Zhu-ming
ZM
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D007825:Laryngectomy; D007830:Larynx / Q000637:transplantation*; D023421:Models, Animal; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344; D014656:Vascular Surgical Procedures / Q000379:methods