Signaling in the immunological synapse: defining the optimal size.
In this issue of Immunity, Varma et al. (2006) report that in the synapses between T cells and planar bilayers, T cell receptor (TCR) proximal signaling takes place in peripheral TCR-microclusters that form continually and that TCR signaling ceases when they fuse with the central supramolecular activation cluster.
Kupfer
Abraham
A
Department of Cell Biology and Program in Immunology at Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, BRB Room 623, Baltimore, Maryland 21205, USA.
D002118:Calcium / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; D002118:Calcium