MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS).
Recent studies suggest that monocyte activation may play a role in ALS pathogenesis. Therefore, monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), and plasma levels of MCP-1 were measured in 42 sALS patients, 38 healthy and 34 age-related macular degeneration (ARMD) controls. MCP-1 was elevated in both sALS and ARMD patients, but CCR2 levels were significantly decreased on sALS but not on ARMD monocytes. Loss of monocyte CCR2 expression was inversely correlated with degree of monocyte/macrophage activation in sALS and this decrease was unlikely due to receptor down-regulation given the ARMD results. Defective monocyte/macrophages may play an active role in sALS.
Zhang
Rongzhen
R
University of California, San Francisco, San Francisco General Hospital, San Francisco, CA 94110, USA.
Gascon
Ron
R
Miller
Robert G
RG
Gelinas
Deborah F
DF
Mass
Jason
J
Lancero
Mariselle
M
Narvaez
Amy
A
McGrath
Michael S
MS
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy / Q000378:metabolism*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008262:Macrophage Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000096:biosynthesis*; D019782:Riluzole / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; C111835:CCL2 protein, human; C515334:CCR2 protein, human; D018932:Chemokine CCL2; D018696:Neuroprotective Agents; D054390:Receptors, CCR2; D019707:Receptors, Chemokine; D019782:Riluzole