[Development of new reactions of fluorine compounds using a rhodium catalyst].
Novel fluoroalkylated products where a CF(2)COOEt group was introduced at the alpha-position of alpha,beta-unsaturated ketones or the Reformatsky-type products have been obtained selectively by the reaction of BrCF(2)COOEt and alpha,beta-unsaturated ketones with Et(2)Zn in the presence of RhCl(PPh(3))(3) depending on the solvents. Furthermore, the novel alpha-fluoroalkylated products could synthesize by using various halofluoroalkyl compounds (R(f)-X) instead of BrCF(2)COOEt. On the other hand, this Reformatsky-type reaction by imines gave difluoro-beta-lactams or 3-amino-2,2-difluorocalboxylic esters without or with MgSO(4) . 7H(2)O, selectively.
Sato
Kazuyuki
K
Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata City, Japan. sato@pharm.setsunan.ac.jp
D000478:Alkylation; D002384:Catalysis; D002625:Chemistry, Organic; D017611:Fluorine Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D008745:Methylation; D055601:Organic Chemistry Phenomena; D012238:Rhodium
D017611:Fluorine Compounds; D012238:Rhodium