title: [A model for trans-translation].
abstract: Trans-translation is a mechanism that fixes stalled translation course. tmRNA is the core of trans-translation and it has dual function as a tRNA and a mRNA. tmRNA recognizes the ribosome carrying truncated mRNA with specificity under the help SmpB protein. It can be directed to A site by ribosomal protein S1. At first tmRNA prolongs the genetic message on the stalled mRNA, then termination codon stops peptide synthesis to form a nascent chain with the tag sequence. Finally, tmRNA-SmpB system frees stalled ribosomes and directs degradation of the products of these frustrated protein synthesis reactions. This paper introduces the most recent studies on trans-translation.
authors.affiliation: Biochemistry & Fermentation Lab of Life Science, Hunan Agricultural University, Changsha 410128, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhou
authors.forename: Yong-Yao
authors.initials: YY
authors.lastname: Wu
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Chen
authors.forename: Fen-You
authors.initials: FY
authors.lastname: Zeng
authors.forename: Yun
authors.initials: Y
authors.lastname: Tian
mesh_terms: D004926:Escherichia coli / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D012333:RNA, Messenger; D012343:RNA, Transfer