[Natural course from rhinitis to asthma in the patients with autumnal pollinosis: a clinical study of 1096 patients].
OBJECTIVE
To investigate the natural course from rhinitis to asthma in the patients with autumnal pollinosis.


METHODS
1096 patients with autumnal pollinosis, 488 males and 632 females, aged 38 +/- 14 (5 - 77), 511 with pure allergic rhinitis and 585 with allergic rhinitis complicated with asthma, underwent skin test of inhalant allergens, serum IgE specific to autumnal pollens, and questionnaire survey.


RESULTS
The age range of rhinitis induced by autumnal pollens was 2 - 75. The peak onset age of rhinitis was 15 - 44, and the peak onset age of asthma was 25 - 54. 33% of the rhinitis patients complicated with asthma (194/585) had their first attack of rhinitis and the first attack of asthma in the same year, 66% of them (386/585) had the first attack of asthma later than the first attack of rhinitis, and only 0.8% of them (5/585) had their first attack of asthma earlier than that of rhinitis. 37% of the patients with autumnal pollen allergic rhinitis (410/1096) developed asthma within 5 years, 47% (511/1096), within 9 years, 5% (58/1096) within 10 approximately 19 years, and 1.5% (16/1096) within 20 - 40 years.


CONCLUSIONS
Almost half of the patients with autumnal pollen allergic rhinitis develop to seasonal allergic asthma within 9 years.
Yin
Jia
J
Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Yue
Feng-min
FM
Wang
Liang-lu
LL
He
Hai-juan
HJ
Xu
Tao
T
Li
Hong
H
Wen
Li-ping
LP
Sun
Jing-lü
JL
Gu
Jian-qing
JQ
Han
Shao-mei
SM
Zhang
Hong-yu
HY
Ye
Shi-tai
ST
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000453:epidemiology*; D011795:Surveys and Questionnaires
D007073:Immunoglobulin E