[Future prospect for identification of schizophrenia susceptive genes].
Identification of the genetic polymorphisms that contribute to susceptibility for schizophrenia have focused on the technique of genetic linkage, but now whole-genome association studies are becoming more feasible. Linkage analyses in families collected from different populations have provided relatively well-defined genomic loci. These have been typically followed by fine mapping studies using single nucleotide polymorphisms (SNPs). In this article, we review the current genetic evidence that implicates schizophrenia-susceptibility genes. Recently, it has been reported that more than 70% of genome regions are transcribed. From this point of view, the genetic study for identification of susceptive genes proceeds to another aspect of genome research.
Iwata
Nakao
N
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake 470-1192, Japan. nakao@fujita-hu.ac.jp
D002352:Carrier Proteins; D002874:Chromosome Mapping; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005544:Forecasting; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D023281:Genomics / Q000639:trends*; D015810:Linkage Disequilibrium; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; D020641:Polymorphism, Single Nucleotide; D051057:Proto-Oncogene Proteins c-akt; D012559:Schizophrenia / Q000235:genetics*
D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; C094131:NRG1 protein, human; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt