title: [Helicobacteriosis and oxidative stress in children with type 1 diabetes mellitus].
abstract: There was a study of 70 children with type 1 diabetes mellitus (DM). The average degree of H. pylori semination of the stomach mucous coat was reliably more frequent in patients with repeated DM decompensation within one year of observation at the admission to in hospital. The average degree of H. pylori semination of the stomach mucous coat was accompanied by an expressed reduction of activity of glutathione reductase in neutrophils against the background of the increase in levels of circulating immune complexes and malonic dialdehyde of blood, i.e. development of oxidative stress. In the course of the study of cytochemical indices in the dynamics it was revealed that patients with repeated DM decompensation within one year of observation had a further drop in the activity of glutathione reductase in neutrophils against the background of the increase in levels of circulating immune complexes and malonic dialdehyde of blood. The revealed activation of oxidative stress reached its maximum in the patients with repeated DM decompensation during one year of follow up.
mesh_terms: D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D004386:Duodenum / Q000382:microbiology / Q000473:pathology*; D004724:Endoscopy; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D005980:Glutathione Reductase / Q000032:analysis; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D009504:Neutrophils / Q000201:enzymology; D018384:Oxidative Stress
chemical_list: D005980:Glutathione Reductase