title: Forensic application of chiral separation of amphetamine-type stimulants to impurity analysis of seized methamphetamine by capillary electrophoresis.
abstract: The applicability of capillary electrophoresis (CE) with a UV detector using highly sulfated gamma-cyclodextrin as a chiral selector was examined for analysis of impurities in seized methamphetamine. Samples of methamphetamine-hydrochloride dissolved in water at a high concentration (20 mg/mL) were analyzed. Electrokinetic injection has an advantage over hydrodynamic injection for improving the detection of trace impurities. Small peaks of the precursor impurities, such as (1R,2S)-(-)-ephedrine and (1S,2S)-(+)-pseudoephedrine, were detected and quantified without extraction. The seized drugs could be classified into three groups based on the contents of the two impurities.
authors.affiliation: National Research Institute of Police Science, Kashiwanoha, Kashiwa, Chiba, Japan. togawa@nrips.go.jp
authors.forename: Yuko T
authors.initials: YT
authors.lastname: Iwata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Kenji
authors.initials: K
authors.lastname: Kuwayama
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Kanamori
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsujikawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Miyaguchi
authors.forename: Tohru
authors.initials: T
authors.lastname: Kishi