New integron-associated gene cassette encoding a trimethoprim-resistant DfrB-type dihydrofolate reductase.
A sixth gene cassette containing a dfrB-type gene, dfrB6, was found in a dfrB6-aadA1 cassette array in class 1 integrons. This array was isolated from several multiply antibiotic-resistant Salmonella enterica serovar Infantis strains that appear to be clonally related. The DfrB6 dihydrofolate reductase conferred resistance to trimethoprim.
Levings
Renee S
RS
New South Wales Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Camden, NSW, Australia.
Lightfoot
Diane
D
Elbourne
Liam D H
LD
Djordjevic
Steven P
SP
Hall
Ruth M
RM
D000595:Amino Acid Sequence; D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology; D001483:Base Sequence; D002415:Cats; D002645:Chickens; D004285:Dogs; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005493:Folic Acid Antagonists / Q000494:pharmacology; D005798:Genes, Bacterial; D032023:Integrons; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D019779:Salmonella enterica / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D017386:Sequence Homology, Amino Acid; D012703:Serotyping; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D014295:Trimethoprim / Q000494:pharmacology; D014296:Trimethoprim Resistance / Q000235:genetics
D000892:Anti-Infective Agents, Urinary; D005493:Folic Acid Antagonists; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase