title: Combined intoxication with methylone and 5-MeO-MIPT.
abstract: Although preclinical studies suggest that methylone (2-methylamino-1-[3,4-methylenedioxyphenyl]propan-1-one) and 5-MeO-MIPT (5-methoxy-N-methyl,N-isopropyl tryptamine) may have psychostimulant properties, the scientific reports about the clinical effects of these agents are scant. We describe a 27-year-old male patient with substance intoxication after a single ingestion of the mixture of methylone and 5-MeO-MIPT. Though he bought the drug as pure methylone powder via an internet order, our chemical analyses indicated that the drug was composed of about 60% methylone (120 mg) and 38% 5-MeO-MIPT (76 mg). This case report suggests that clinicians should be alert to the possibility of the emergence of methylone or 5-MeO-MIPT intoxication, and substance-related mental disorder may be complicated by combined use of other psychoactive drugs.
authors.affiliation: Department of Integrative Neurophysiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuouku, Chiba 260-8670, Japan. eiji@faculty.chiba-u.jp
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Kojima
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hagiwara
authors.forename: Mihisa
authors.initials: M
authors.lastname: Fujisaki
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Miyatake
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
mesh_terms: D000328:Adult; D017109:Akathisia, Drug-Induced / Q000523:psychology; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000032:analysis / Q000506:poisoning; D011605:Psychoses, Substance-Induced / Q000523:psychology*; D019966:Substance-Related Disorders / Q000523:psychology*; D014363:Tryptamines / Q000032:analysis / Q000506:poisoning*
chemical_list: D014363:Tryptamines; D008694:Methamphetamine; C517919:5-methoxy-N-methyl,N-isopropyl tryptamine; C400939:methylone