title: Are age, anthropometry and components of metabolic syndrome-risk factors interrelated with lower urinary tract symptoms in patients with erectile dysfunction? A prospective study.
abstract: OBJECTIVE
  To evaluate the effects of metabolic profiles on lower urinary tract symptoms (LUTS) in men with erectile dysfunction (ED).
  
  
  METHODS
  A total of 75 impotent men aged 25-75 years old (mean 58.1 years) were included in the study on a prospective basis. Patients were evaluated with a complete history, physical examination, anthropometry and metabolic profiles. LUTS were assessed using the International Prostate Symptom Score (IPSS).
  
  
  RESULTS
  Overall, there was no correlation between the IPSS and continuous parameters. However, when continuous variables were categorized, some parameters were significantly associated with LUTS. Patients with triglyceride level of 150 mg/dL or higher had more severe symptoms than those with triglyceride levels less than 150 mg/dL (19.4 +/- 2.4 vs. 14.3 +/- 1.1, P = 0.033). When 40 mg/dL was chosen as the high-density lipoprotein (HDL)-cholesterol cut-off level, the IPSS was significantly different between the two groups divided by 40 mg/dL (19.4 +/- 2.6 for HDL-cholesterol < 40 mg/dL vs. 14.4 +/- 1.0 for HDL-cholesterol = or > 40 mg/dL, P = 0.042). The area under the receiver operating characteristic curve (AUROCC) of triglyceride was 65.7% (95% confidence interval [CI], 52.6%-82.3%; P = 0.034) for severe LUTS. However, the AUROCC for 'HDL-cholesterol' was not significant (area, 65.4%; 95% CI, 48.2%-82.7%; P = 0.062). No other factors were determined to be significant in this regard.
  
  
  CONCLUSIONS
  The results of the present study indicate that some metabolic profiles might influence LUTS in men with ED.
authors.affiliation: Department of Urology, Seoul Veterans Hospital, 6-2, Doonchon Dong, Kangdong Ku, Seoul 134791, Korea.
authors.forename: Jae-Seung
authors.initials: JS
authors.lastname: Paick
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Yang
authors.forename: Soo-Woong
authors.initials: SW
authors.lastname: Kim
authors.forename: Ja-Hyeon
authors.initials: JH
authors.lastname: Ku
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D015992:Body Mass Index; D007172:Erectile Dysfunction / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014570:Urologic Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*
chemical_list: D014280:Triglycerides