title: The descent of memory T-cell subsets.
abstract: The immune system has evolved by continuously increasing its complexity to provide the host with an advantage over infectious agents. The development of immunological memory engenders long-lasting protection and lengthens the lifespan of the host. The generation of subsets of memory T cells with distinct homing and functional properties increases our defensive capabilities. However, the developmental relationship of memory T-cell subsets is a matter of debate. In this Opinion article, in light of recent developments, we suggest that it is probable that two distinct lineages comprise the memory CD8+ T-cell population generated in response to infection.
authors.affiliation: University of Connecticut Health Center, Department of Immunology, Farmington, Connecticut 06030, USA. llefranc@neuron.uchc.edu
authors.forename: Leo
authors.initials: L
authors.lastname: Lefrançois
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Marzo
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000166:cytology / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D019041:L-Selectin / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D018448:Models, Immunological; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
chemical_list: D019041:L-Selectin