title: Oncological problems in pancreatic cancer surgery.
abstract: Despite the development of more sophisticated diagnostic techniques, pancreatic carcinoma has not yet been detected in the early stage. Surgical resection provides the only chance for cure or long-term survival. The resection rate has increased due to recent advances in surgical techniques and the application of extensive surgery. However, the postoperative prognosis has been poor due to commonly occurring liver metastasis, local recurrence and peritoneal dissemination. Recent molecular-biological studies have clarified occult metastasis, micrometastasis and systemic disease in pancreatic cancer. Several oncological problems in pancreatic cancer surgery are discussed in the present review.
authors.affiliation: Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. nakaoaki@med.nagoya-u.ac.jp
authors.forename: Akimasa
authors.initials: A
authors.lastname: Nakao
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujii
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Naohito
authors.initials: N
authors.lastname: Kanazumi
authors.forename: Shuji
authors.initials: S
authors.lastname: Nomoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kodera
authors.forename: Soichiro
authors.initials: S
authors.lastname: Inoue
authors.forename: Shin
authors.initials: S
authors.lastname: Takeda
mesh_terms: D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D015994:Incidence; D008207:Lymphatic Metastasis / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D009361:Neoplasm Invasiveness / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control; D009367:Neoplasm Staging; D010179:Pancreas / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant