title: [Analysis of relevant factors causing laryngeal stenosis after partial laryngectomy].
abstract: OBJECTIVE
  To investigate the clinical relevant factors causing laryngeal stenosis after partial laryngectomy.
  
  
  METHODS
  A retrospective study was carried out to review the history clinical data from 138 patients of partial laryngectomy in the First Affiliated Hospital of Sun Yat-Sen University between January 1994 to October 2004. The clinical relevant factors causing laryngeal stenosis were included as follows: age, sex, TNM stage, tumor site, extension of thyroid cartilage defect, extension of larynx parenchyma defect, reconstruction method, laryngeal dilator, duration of using antibiotics, postoperative radiotherapy, lung infection, gastroesophageal reflux, diabetes. Multivariate stepwise logistic regression model was used for the analysis.
  
  
  RESULTS
  Of 138 cases after partial laryngectomy, stenosis developed in 25 cases. The occurrence rate was 18.1%. In multivariate analysis, it was confirmed that the following factors correlated to laryngeal stenosis, i. e, extension of thyroid cartilage defect (chi2 = 4.323, P = 0.038), postoperative radiotherapy (chi2 = 6.002, P = 0.014), lung infection (chi2 = 4.220, P = 0.040), and gastroesophageal reflux (chi2 = 5.614, P = 0.018).
  
  
  CONCLUSIONS
  The clinical relevant factors causing laryngeal stenosis after partial laryngectomy were multiple. Statistical analysis showed that extension of thyroid cartilage defect, postoperative radiotherapy, lung infection and gastroesophageal reflux were the risk factors which may cause laryngeal stenosis.
authors.affiliation: Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wu
authors.forename: Zhen-zhong
authors.initials: ZZ
authors.lastname: Su
authors.forename: Ai-yun
authors.initials: AY
authors.lastname: Jiang
authors.forename: Ai-hua
authors.initials: AH
authors.lastname: Lin
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Chai
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Wen
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Lei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery; D007825:Laryngectomy / Q000009:adverse effects*; D007829:Laryngostenosis / Q000209:etiology* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors