title: The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women.
abstract: BACKGROUND
  Because serum paraoxonase activity is influenced by the -108C/T polymorphism in the PON1 gene, we studied its involvement in the decreased paraoxonase activity recently described in the polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Paraoxonase activity, PON1-108C/T genotypes and clinical, hormonal and biochemical variables were evaluated in a case-control study involving 139 consecutive PCOS patients and 85 healthy controls matched for BMI and prevalence of smoking.
  
  
  RESULTS
  Women homozygous for -108T presented with reduced serum paraoxonase activity compared with carriers of C alleles (P < 0.001), both in PCOS patients and in controls. Although homozygosity for T alleles was more prevalent in PCOS patients than in controls (P = 0.003), serum paraoxonase activity was not significantly different in the PCOS and control groups. In a stepwise multivariate linear regression model, homozygosity for PON1-108T alleles was the only significant predictor of the logarithm of serum paraoxonase activity (beta = -0.328, t = -4.176, P < 0.001).
  
  
  CONCLUSIONS
  In premenopausal women from the Spanish population, the PON1-108C/T polymorphism, and not PCOS, is an important determinant of serum paraoxonase activity.
authors.affiliation: Department of Molecular Genetics, Hospital Universitario Ramón y Cajal, Madrid, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: San Millán
authors.forename: Francisco
authors.initials: F
authors.lastname: Alvarez-Blasco
authors.forename: Manuel
authors.initials: M
authors.lastname: Luque-Ramírez
authors.forename: José I
authors.initials: JI
authors.lastname: Botella-Carretero
authors.forename: Héctor F
authors.initials: HF
authors.lastname: Escobar-Morreale
mesh_terms: D043303:Aryldialkylphosphatase / Q000097:blood* / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011110:Polymorphism, Genetic; D017697:Premenopause / Q000235:genetics*
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human