title: Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines.
abstract: We report herein the SAR studies of a series of indole-imidazole compounds. that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types, including hematologic and solid tumor cell lines of various origins (e.g., leukemia, breast, colon, and uterine).
authors.affiliation: Synta Pharmaceuticals, 45 Hartwell Ave, Lexington, MA 02421, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: James
authors.forename: Keizo
authors.initials: K
authors.lastname: Koya
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Shoujun
authors.initials: S
authors.lastname: Chen
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Xia
authors.forename: Weiwen
authors.initials: W
authors.lastname: Ying
authors.forename: Yaming
authors.initials: Y
authors.lastname: Wu
authors.forename: Lijun
authors.initials: L
authors.lastname: Sun
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D007211:Indoles