Determination of water in penicillins using fast Karl Fischer reagents and electronic end-point optimization.
When using conventional Karl Fischer reagents for titration of water in penicillins, decomposition products (i.e. penicilloic acid) are shown to be partly cotitrated. Water in ampicillin, bacampicillin, carboxybenzylpenicillin and cloxacillin was titrated with slow and fast reagents and the differences in the results obtained were compared with the content of penicilloic acid determined mercurimetrically. A simple electronic control unit has been developed to optimize the speed of titration.
Lindquist
J
J
Astra Läkemedel AB, Research and Development Laboratories, Pharmaceutical Analysis, S-15185 Södertälje, Sweden.