title: Labdanes and withanolides from Physalis coztomatl.
abstract: Aerial parts of Physalis coztomatl afforded a new labdane diterpene, physacoztomatin (1), and five new withanolides, physacoztolides A-E (5-9). Six known compounds were also isolated. The structures of the new compounds were established after analyses of their spectroscopic data and by means of chemical transformations. X-ray diffraction analyses of 15-dehydrophysacoztomatin (2) and 5 confirmed the structures of 1 and 5. Labd-13(E)-ene-8alpha,15-diol (4) and physacoztomatin (1) represent the first labdane diterpenes isolated from the genus Physalis.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacan 04510, DF, México. alperezc@servidor.unam.mx
authors.forename: Ana-L
authors.initials: AL
authors.lastname: Pérez-Castorena
authors.forename: Ruth F
authors.initials: RF
authors.lastname: Oropeza
authors.forename: Alma R
authors.initials: AR
authors.lastname: Vazquez
authors.forename: Mahinda
authors.initials: M
authors.lastname: Martínez
authors.forename: Emma
authors.initials: E
authors.lastname: Maldonado
mesh_terms: D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008800:Mexico; D008968:Molecular Conformation; D015394:Molecular Structure; D032321:Physalis / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D004224:Diterpenes; C513453:physacoztomatin; D004875:Ergosterol