title: Qualitative aspects of the degradation of mitomycins in alkaline solution.
abstract: The major degradation product in alkaline solution of mitomycin A, mitomycin C and porfiromycin is the corresponding 7-hydroxymitosane. The isolation and the physico-chemical and analytical properties of these compounds and their derivatized analogues are discussed. Data are presented on the degradation of mitomycin C at extremely high pH values.
authors.affiliation: Department of Analytical Pharmacy, Subfaculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511 GH Utrecht, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: J
authors.initials: J
authors.lastname: den Hartigh
authors.forename: W J
authors.initials: WJ
authors.lastname: Underberg