Steroid sulfatase in breast carcinoma and change of serum estrogens levels after operation.
Fifty-four breast carcinomas were studied for the expression of steroid sulfatase (STS) by immunohistochemistry. Correlations between the expression of STS and clinical parameters were determined. Concentrations of serum estrone (E1), estrone sulfate (E1S), estradiol (E2) and estradiol sulfate (E2S) in 12 postmenopausal patients with STS positive tumor were measured by radioimmunoassay. Positive expression of STS was obtained in 72% of tumors. The incidence of STS positive tumor was significantly more frequent in postmenopausal patients (p = 0.01). In our postmenopausal patients, serum E1, E1S, E2, E2S and E2S levels in STS high score group were decreased postoperatively, and those in both STS high and low score group were stabilized after operation. Results from this study suggest STS in breast carcinoma may play an important enzyme of the intratumoral estrogen synthesis in postmenopausal women, and it would be interesting that locally produced STS might be closely related to the control of estrogens environment in breast carcinoma.
Tsunoda
Yuko
Y
Second Department of Surgery, School of Medicine, Showa University, Tokyo, Japan. at1151proc@med.showa-u.ac.jp
Shimizu
Yukiko
Y
Tsunoda
Akira
A
Takimoto
Masafumi
M
Sakamoto
Masa-Aki
MA
Kusano
Mitsuo
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D004967:Estrogens / Q000096:biosynthesis / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D047648:Perimenopause; D017698:Postmenopause; D011863:Radioimmunoassay; D012680:Sensitivity and Specificity; D013194:Staining and Labeling; D043266:Steryl-Sulfatase / Q000032:analysis / Q000096:biosynthesis*
D004967:Estrogens; D043266:Steryl-Sulfatase