Association between suicide attempts in south Brazilian depressed patients with the serotonin transporter polymorphism.
A polymorphism in the serotonin transporter gene (5-HTTLPR) is being studied for association with suicidal behavior. We verified the relationship between the frequencies of the 5-HTTLPR alleles in 84 depressed patients with suicide attempts compared with 152 controls. We found a higher risk for suicide behavior among depressed patients bearing SS or LS genotypes.
Segal
Jair
J
Post Graduate Program in Medical Sciences: Psychiatry, Universidade Federal do Rio Grande do Sul. Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil.
Pujol
Clarissa
C
Birck
Alan
A
Gus Manfro
Gisele
G
Leistner-Segal
Sandra
S
D000328:Adult; D000483:Alleles; D001938:Brazil; D003865:Major Depressive Disorder / Q000208:ethnology / Q000235:genetics* / Q000523:psychology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013406:Suicide, Attempted / Q000208:ethnology / Q000523:psychology*; D014754:Violence / Q000208:ethnology / Q000523:psychology
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins