title: Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV.
abstract: In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.
authors.affiliation: Department of Microbiology, University of Chicago, 920 E. 58th Street, Chicago, Illinois 60637, USA.
authors.forename: Kristin L
authors.initials: KL
authors.lastname: DeBord
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Anderson
authors.forename: Melanie M
authors.initials: MM
authors.lastname: Marketon
authors.forename: Katie A
authors.initials: KA
authors.lastname: Overheim
authors.forename: R William
authors.initials: RW
authors.lastname: DePaolo
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Ciletti
authors.forename: Bana
authors.initials: B
authors.lastname: Jabri
authors.forename: Olaf
authors.initials: O
authors.lastname: Schneewind
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010930:Plague / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control*; D010931:Plague Vaccine / Q000008:administration & dosage / Q000276:immunology*; D052899:Pore Forming Cytotoxic Proteins; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology*; D014611:Vaccination; D015010:Yersinia pestis / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; C043908:LcrV protein, Yersinia; D010931:Plague Vaccine; D052899:Pore Forming Cytotoxic Proteins; D011994:Recombinant Proteins