title: Clinical catecholamine neurochemistry: a legacy of Julius Axelrod.
abstract: 1. Discoveries, insights, and concepts that Julius Axelrod introduced about the disposition and metabolism of catecholamines provided the scientific basis and spurred the development of clinical catecholamine neurochemistry. 2. Here, we provide examples of this aspect of Axelrod's scientific legacy.
authors.affiliation: Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1620, USA. goldsteind@ninds.nih.gov
authors.forename: David S
authors.initials: DS
authors.lastname: Goldstein
authors.forename: Graeme
authors.initials: G
authors.lastname: Eisenhofer
authors.forename: Irwin J
authors.initials: IJ
authors.lastname: Kopin
mesh_terms: D000224:Addison Disease / Q000209:etiology; D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000175:diagnosis; D000818:Animals; D002395:Catecholamines / Q000097:blood / Q000502:physiology*; D006321:Heart / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D008676:Metanephrine / Q000097:blood; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000032:analysis; D008954:Models, Biological; D009424:Nervous System Physiological Phenomena; D009448:Neurochemistry; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000032:analysis; D010300:Parkinson Disease / Q000503:physiopathology; D010625:Phenylethanolamine N-Methyltransferase / Q000378:metabolism; D010673:Pheochromocytoma / Q000097:blood / Q000175:diagnosis
chemical_list: D002395:Catecholamines; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D008676:Metanephrine; D008734:Methoxyhydroxyphenylglycol; D010625:Phenylethanolamine N-Methyltransferase; C010117:3,4-dihydroxyphenylglycol