title: Staphyloxanthin plays a role in the fitness of Staphylococcus aureus and its ability to cope with oxidative stress.
abstract: Staphyloxanthin is a membrane-bound carotenoid of Staphylococcus aureus. Here we studied the interaction of staphyloxanthin with reactive oxygen substances (ROS) and showed by comparative analysis of the wild type (WT) and an isogenic crtM mutant that the WT is more resistant to hydrogen peroxide, superoxide radical, hydroxyl radical, hypochloride, and neutrophil killing.
authors.affiliation: Mikrobielle Genetik, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Clauditz
authors.forename: Alexandra
authors.initials: A
authors.lastname: Resch
authors.forename: Karsten-Peter
authors.initials: KP
authors.lastname: Wieland
authors.forename: Andreas
authors.initials: A
authors.lastname: Peschel
authors.forename: Friedrich
authors.initials: F
authors.lastname: Götz
mesh_terms: D015169:Colony Count, Microbial; D003470:Culture Media; D018869:Heat-Shock Response; D009154:Mutation; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress / Q000502:physiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D024341:Xanthophylls / Q000235:genetics / Q000378:metabolism*
chemical_list: D003470:Culture Media; D016877:Oxidants; D024341:Xanthophylls; C031841:staphyloxanthin