Pattern recognition receptors: a contemporary view on liver diseases.
Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver. This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated.
Szabo
Gyongyi
G
Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. gyongyi.szabo@umassmed.edu
Dolganiuc
Angela
A
Mandrekar
Pranoti
P
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000502:physiology*
D015415:Biomarkers; D051192:Receptors, Pattern Recognition