Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake.
Many health benefits are associated with a high dietary intake of vegetables and fruit (VF); however, little effort has been expended to determine whether the botanical families from which high-VF diets are formulated affect their biological activities. The objective of this study was to determine whether the botanical diversity of high-VF diets alters the response in oxidative biomarkers for lipid peroxidation and DNA oxidation. Two diets were developed that varied in botanical diversity and provided 8-10 servings of VF/d. The high botanical diversity diet (HBD) included foods from the 18 botanical families that induced a reduction in oxidative damage of lipids or DNA. The low botanical diversity diet (LBD) emphasized 5 of these botanical families based on reports that their bioactive components had high antioxidant activity. A total of 106 women completed the study. Participants consumed 9.1 +/- 2.6 and 8.3 +/- 2.1 servings of VF/d with the LBD and HBD diets. Only the HBD diet induced a significant reduction in DNA oxidation (P < 0.05). Both the LBD and the HBD diets were associated with a reduction in lipid peroxidation (P < 0.01). These findings indicate that botanical diversity plays a role in determining the bioactivity of high-VF diets and that smaller amounts of many phytochemicals may have greater beneficial effects than larger amounts of fewer phytochemicals.
Thompson
Henry J
HJ
Colorado State University, Fort Collins, CO 80523, USA. henry.thompson@colostate.edu
Heimendinger
Jerianne
J
Diker
Ann
A
O'Neill
Caitlin
C
Haegele
Al
A
Meinecke
Becky
B
Wolfe
Pamela
P
Sedlacek
Scot
S
Zhu
Zongjian
Z
Jiang
Weiqin
W
D015415:Biomarkers / Q000097:blood / Q000652:urine; D002338:Carotenoids / Q000097:blood; D004032:Diet; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005638:Fruit / Q000145:classification*; D006801:Humans; D015227:Lipid Peroxidation; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D014662:Vasoconstrictor Agents / Q000097:blood; D014675:Vegetables / Q000145:classification*
D015415:Biomarkers; D014662:Vasoconstrictor Agents; C075750:8-epi-prostaglandin F2alpha; D002338:Carotenoids; D015237:Dinoprost