title: Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.
abstract: A focused library of variously substituted 9-aminoacridine compounds was screened for bioactivity against accumulation of the infectious prion protein isoform, denoted PrP(Sc), in a cell model of prion replication. The efficacy of compounds against PrP(Sc) accumulation was influenced by both substituents of the distal tertiary amine and acridine heterocycle, while cellular cytotoxicity was encoded in the acridine heterocycle substituents.
authors.affiliation: Institute for Neurodegenerative Diseases, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA. bmay@ind.ucsf.edu
authors.forename: Barnaby C H
authors.initials: BC
authors.lastname: May
authors.forename: Juanita
authors.initials: J
authors.lastname: Witkop
authors.forename: John
authors.initials: J
authors.lastname: Sherrill
authors.forename: Marc O
authors.initials: MO
authors.lastname: Anderson
authors.forename: Peter B
authors.initials: PB
authors.lastname: Madrid
authors.forename: Julie A
authors.initials: JA
authors.lastname: Zorn
authors.forename: Stanley B
authors.initials: SB
authors.lastname: Prusiner
authors.forename: Fred E
authors.initials: FE
authors.lastname: Cohen
authors.forename: R Kiplin
authors.initials: RK
authors.lastname: Guy
mesh_terms: D000585:Aminacrine / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009447:Neuroblastoma / Q000473:pathology*; D012608:Scrapie; D013329:Structure-Activity Relationship
chemical_list: D000585:Aminacrine