Two new monodesmosidic triterpene saponins from Gypsophila oldhamiana.
Two new monodesmosidic triterpene saponins were isolated from the roots of Gypsophila oldhamiana (Caryophyllaceae). Their structures were elucidated on the basis of spectral data to be quillaic acid, alpha-L-arabinopyranosyl-(1-->4)-alpha-L-arabinopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranosyl ester (1), and vaccaric acid, beta-D-glucopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranosyl ester (2). Compound 1 showed a significant enhancement of granulocyte phagocytosis in vitro.
Luo
Jian-Guang
JG
Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang. Nanjing 210009, People's Repubic of China.
Kong
Ling-Yi
LY
Takaya
Yoshiaki
Y
Niwa
Masatake
M
D000818:Animals; D029748:Caryophyllaceae / Q000737:chemistry*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D008213:Lymphocyte Activation / Q000187:drug effects; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry*
D012503:Saponins; D014315:Triterpenes; C513999:quillaic acid arabinopyranosyl-1-4-arabinopyranosyl-1-3-xylopyranosyl-1-4-rhamnopyranosyl-1-2-fucopyranosyl ester; C514000:vaccaric acid glucopyranosyl-1-3-(xylopyranosyl-1-4)-rhamnopyranosyl-1-2-fucopyranosyl ester