Early cytokine responses after percutaneous magnetic resonance imaging guided laser thermoablation of malignant liver tumors.
An early systemic response induced by magnetic resonance imaging (MRI)-guided interstitial percutaneous laser thermoablation was analyzed in 13 consecutive patients with malignant liver tumors by serum interleukin (IL)-1beta, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, its receptor TNFRI, and C-reactive protein (CRP) levels up to 72h after the procedures. Only IL-6 (p=0.033) and TNFRI (p<0.001) increased statistically significantly after ablation, while the TNF-alpha, IL-1 beta, and IL-10 levels remained unchanged. The peak median CRP response was 92mg/l. There was a dose-dependent correlation between the energy used and the maximum CRP values (tau=0.68, p=0.013). MRI-guided laser thermoablation induced an early systemic inflammatory reaction with statistically significantly elevated IL-6, TNFRI, and CRP levels but not TNF-alpha or IL-10 levels and without procedure-related complications, favoring this procedure as a safe therapeutic alternative for well-selected patients with liver tumors.
Kallio
Raija
R
Department of Oncology and Radiotherapy, Oulu University Hospital, P.O. Box 22, FIN-90029 OYS, Oulu, Finland. raija.kallio@oulu.fi
Sequeiros
Roberto
R
Surcel
Heljä-Marja
HM
Ohtonen
Pasi
P
Kiviniemi
Heikki
H
Syrjälä
Hannu
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008113:Liver Neoplasms / Q000097:blood* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012867:Skin; D013696:Temperature; D013997:Time Factors
D016207:Cytokines