title: Impact of newly diagnosed breast cancer on quality of life among Chinese women.
abstract: BACKGROUND
  Being diagnosed with breast cancer is a very stressful event that has a profound impact on multiple aspects of a patient's daily life. Little is known about the quality of life (QOL) of Chinese women with newly diagnosed breast cancer.
  
  
  METHODS
  The authors evaluated QOL in 2,236 Chinese women with newly diagnosed breast cancer who were recruited into the Shanghai Breast Cancer Survival Study between April 1, 2002 and March 31, 2004. Patients' QOL was assessed after cancer diagnosis (median time 6.4 months; range 3.6-11.1 months) by using the General Quality of Life Inventory. Multiple linear regression models were used to analyze the associations of QOL outcomes with medical and socio-demographic factors.
  
  
  RESULTS
  Patients showed significantly worse overall QOL and perceived health status than healthy women, reflected mainly by lower QOL scores in physical and psychological well-being domains. Completion of radiotherapy, ever use of tamoxifen, being underweight, having an increased number of chronic diseases, and low household income were significantly associated with lower overall QOL scores after adjusting for other factors. Age at diagnosis was inversely associated with physical well-being, positively associated with material well-being, and had minimal influence on overall QOL. Stage of disease, chemotherapy, and education were only associated with certain domains, but had no influence on overall QOL. Estrogen receptor/progesterone receptor status and type of surgery or immunotherapy did not appear to be associated with QOL.
  
  
  CONCLUSIONS
  The findings of the present study provide important information on QOL and their correlates among Chinese women with newly diagnosed breast cancer and are helpful in developing treatment strategies accordingly.
authors.affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.forename: Kai
authors.initials: K
authors.lastname: Gu
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Xiao Ou
authors.initials: XO
authors.lastname: Shu
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D044466:Asian People / Q000523:psychology*; D001943:Breast Neoplasms / Q000208:ethnology / Q000523:psychology* / Q000628:therapy; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011788:Quality of Life; D018570:Risk Assessment; D012944:Social Support; D013315:Stress, Psychological; D011795:Surveys and Questionnaires; D013997:Time Factors