title: Adrenergic receptor polymorphisms and autonomic nervous system function in human obesity.
abstract: Adrenergic receptors (ARs) are cell-surface G-protein-coupled receptors for catecholamines. They are essential components of the sympathetic nervous system, organized within the autonomic nervous system (ANS), which controls various physiological functions, including energy homeostasis and metabolism of glucose and lipids. An impairment of ANS function in metabolism is considered to be one of the pathological states associated with human obesity and related metabolic diseases; thus, alterations in AR function might be implicated in the pathophysiology of these diseases. Several studies have suggested an association between obesity phenotypes and some AR polymorphisms. In vitro and human clinical studies indicate that some of these polymorphisms have functional and pathophysiological significance, including the linkage to ANS function. This review summarizes present knowledge of AR polymorphisms related to human obesity, and their association with ANS function.
authors.affiliation: Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, and Diabetic Center, Tsunashimakai-Kosei Hospital, Himeji, Japan. yasuda2@tom.life.h.kyoto-u.ac.jp
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yasuda
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Adachi
authors.forename: Norihiko
authors.initials: N
authors.lastname: Aoki
authors.forename: Gozoh
authors.initials: G
authors.lastname: Tsujimoto
authors.forename: Kinsuke
authors.initials: K
authors.lastname: Tsuda
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology*; D019204:GTP-Binding Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011941:Receptors, Adrenergic / Q000235:genetics*
chemical_list: D011941:Receptors, Adrenergic; D019204:GTP-Binding Proteins