title: Pediatric multiple sclerosis: detection of clinically silent lesions by multimodal evoked potentials.
abstract: Pediatric patients with multiple sclerosis (MS) frequently do not meet MRI criteria for diagnosis because of lack of evidence of dissemination in space. We assessed the diagnostic utility of multimodal evoked potentials (EP). In 46% of 85 childhood patients with MS, spatial dissemination was detected by EP before the second clinical attack. EP may constitute an important tool for earlier diagnosis of pediatric MS.
authors.affiliation: Department of Pediatrics and Pediatric Neurology, Georg August University Goettingen, Germany. dpohl@med.uni-goettingen.de
authors.forename: Daniela
authors.initials: D
authors.lastname: Pohl
authors.forename: Kevin
authors.initials: K
authors.lastname: Rostasy
authors.forename: Stephanie
authors.initials: S
authors.lastname: Treiber-Held
authors.forename: Knut
authors.initials: K
authors.lastname: Brockmann
authors.forename: Jutta
authors.initials: J
authors.lastname: Gärtner
authors.forename: Folker
authors.initials: F
authors.lastname: Hanefeld
mesh_terms: D000293:Adolescent; D002648:Child; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology*; D009460:Neurologic Examination; D012189:Retrospective Studies