title: Bisabolanes from the red alga Laurencia scoparia.
abstract: Three novel halogenated beta-bisabolene sesquiterpenoids (1-3), together with two know triquinane alcohol sesquiterpenes (6 and 7), were isolated from the red alga Laurencia scoparia and their structures elucidated by spectroscopic methods. Single-crystal X-ray crystallography allowed us to confirm the structure of 1 as well as to determine the absolute configuration of all stereocenters. To the best of our knowledge, the isolation of beta-bisabolenes from the genus Laurencia has no precedent in the literature. Compound 1 showed weak in vitro anthelmintic activity against parasitant stage (L4) Nippostrongilus brasiliensis.
authors.affiliation: Facultad de Química, Universidad de la República, Avenida Gral. Flores 2124, Montevideo, Uruguay.
authors.forename: Danilo
authors.initials: D
authors.lastname: Davyt
authors.forename: Rafael
authors.initials: R
authors.lastname: Fernandez
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Suescun
authors.forename: Alvaro W
authors.initials: AW
authors.lastname: Mombrú
authors.forename: Jenny
authors.initials: J
authors.lastname: Saldaña
authors.forename: Laura
authors.initials: L
authors.lastname: Domínguez
authors.forename: Mutue T
authors.initials: MT
authors.lastname: Fujii
authors.forename: Eduardo
authors.initials: E
authors.lastname: Manta
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D018360:Crystallography, X-Ray; D044722:Laurencia / Q000737:chemistry*; D015394:Molecular Structure; D009559:Nippostrongylus / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000871:Anthelmintics; D012717:Sesquiterpenes