title: N-hexacosanol ameliorates streptozotocin-induced diabetic rat nephropathy.
abstract: In this study we investigated the effects of N-hexacosanol on streptozotocin-induced rat diabetic nephropathy. Diabetes was induced in 8-week-old male Sprague-Dawley rats by administering an intraperitoneal injection of streptozotocin (50 mg/kg). The rats were divided into four groups and maintained for 8 weeks: control rats, diabetic rats without treatment with N-hexacosanol, and diabetic rats treated with N-hexacosanol (2 mg/kg and 8 mg/kg i.p. every day). Although N-hexacosanol failed to modify the diabetic status, increases in serum creatinine as well as in kidney weight were significantly reduced. The malonaldehyde and transforming growth factor beta-1 (TGF-beta1) concentrations as well as the protein kinase C (PKC) activities in the diabetic kidney were significantly higher than those of the control, which were decreased by treatment with N-hexacosanol. Histological examinations revealed that N-hexacosanol significantly ameliorated diabetic-induced tubulointerstitial pathological changes. Our data suggest that N-hexacosanol could prevent increases in the malonaldehyde and TGF-beta1 concentrations and PKC activities in the kidney, and ameliorate diabetic-induced nephropathy.
authors.affiliation: Department of Pathophysiological and Therapeutic Science, Division of Molecular Pharmacology, Tottori University Faculty of Medicine, 86 Nishimachi, Yonago 683-8503, Japan. saitomo@grape.med.tottori-u.ac.jp
authors.forename: Motoaki
authors.initials: M
authors.lastname: Saito
authors.forename: Yukako
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Itaru
authors.initials: I
authors.lastname: Satoh
authors.forename: Chiko
authors.initials: C
authors.lastname: Shinbori
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Kono
authors.forename: Takuya
authors.initials: T
authors.lastname: Hanada
authors.forename: Jiro
authors.initials: J
authors.lastname: Uemasu
authors.forename: Hiroto
authors.initials: H
authors.lastname: Suzuki
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Satoh
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000139:chemically induced* / Q000473:pathology*; D005233:Fatty Alcohols / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D005233:Fatty Alcohols; D007328:Insulin; D053773:Transforming Growth Factor beta1; D008315:Malondialdehyde; D013311:Streptozocin; D003404:Creatinine; D011493:Protein Kinase C; C051942:1-hexacosanol