Fluorimetric analysis of mebendazole and flubendazole with hydrogen peroxide.
Analytically useful fluorescence was obtained from mebendazole and flubendazole after reaction with hydrogen peroxide in alkaline solution. The fluorescence produced (lambda(ex) = 300 nm; lambda(em) = 360 nm) is stable and concentrations of 0.1 mug ml(-1) can be determined. The method has been applied to the analysis of some commercially available anthelmintic preparations.
Baeyens
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Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmaceutical Sciences, State University of Ghent, Harelbekestraat 72, B-9000-Ghent, Belgium.
Fattah
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De Moerloose
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