[A reviewing for profiling of highly degraded remains].
It's always a challenge to type from highly degraded biological remains. PCR-based STR genotyping is helpful and valuable for such degraded samples like bones, teeth et al, but the typing results are sometimes unstable or wrong. Here the methods for solving the problems and improving reproducibility are reviewed.
He
Bai-Fang
BF
Department of forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. healytomato@163.com
Lou
Di-Dong
DD
D001842:Bone and Bones; D004247:DNA / Q000032:analysis; D053836:DNA Degradation, Necrotic; D016172:DNA Fingerprinting / Q000379:methods*; D018732:Forensic Anthropology; D005819:Genetic Markers; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D020080:Tandem Repeat Sequences; D014070:Tooth / Q000737:chemistry
D005819:Genetic Markers; D004247:DNA