title: Virulence attenuation and phenotypic variation of Paracoccidioides brasiliensis isolates obtained from armadillos and patients.
abstract: Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, the most important systemic mycosis in Latin America. The virulence profiles of five isolates of P. brasiliensis were studied in two different moments and correlated with some colonial phenotypic aspects. We observed a significant decrease in the virulence and an intense phenotypic variation in the mycelial colony. The recognition of all ranges of phenotypic and virulence variation of P. brasiliensis, as well as its physiological and genetic basis, will be important for a better comprehension of its pathogenic and epidemiological features.
authors.affiliation: Departamento de Microbiologia e Imunologia, Instituto de Biociêncas, SP, Brasil.
authors.forename: S A G
authors.initials: SA
authors.lastname: Macoris
authors.forename: M F
authors.initials: MF
authors.lastname: Sugizaki
authors.forename: M T S
authors.initials: MT
authors.lastname: Peraçoli
authors.forename: S M G
authors.initials: SM
authors.lastname: Bosco
authors.forename: F
authors.initials: F
authors.lastname: Hebeler-Barbosa
authors.forename: L B
authors.initials: LB
authors.lastname: Simões
authors.forename: R C
authors.initials: RC
authors.lastname: Theodoro
authors.forename: L A
authors.initials: LA
authors.lastname: Trinca
authors.forename: E
authors.initials: E
authors.lastname: Bagagli
mesh_terms: D000818:Animals; D001135:Armadillos / Q000382:microbiology; D015169:Colony Count, Microbial; D006224:Cricetinae; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D010228:Paracoccidioides / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D010229:Paracoccidioidomycosis / Q000382:microbiology*; D010641:Phenotype; D013737:Testis / Q000382:microbiology; D013997:Time Factors; D014774:Virulence / Q000235:genetics