Hypotonic stress enhances slope conductivity of ATP-sensitive K+ channels activated pharmacologically.
The aim of this paper was to find out the effects of hypotonic stress on the slope conductivity of ATP-sensitive K(+) channels. Using patch clamp technique, rilmakalim and pinacidil as the activators and glibenclamide as an inhibitor of mentioned channels, we have demonstrated that short hypotonic challenge doubled slope conductivity of exploring channels by augmentation of their open probability.
Kocić
Ivan
I
Hirano
Yuji
Y
Petrusewicz
Jacek
J
Hiraoka
Masayasu
M
D000255:Adenosine Triphosphate; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002839:Chromans / Q000494:pharmacology; D005260:Female; D005905:Glyburide / Q000494:pharmacology; D006168:Guinea Pigs; D007038:Hypotonic Solutions / Q000494:pharmacology*; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000502:physiology; D020110:Pinacidil / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D002839:Chromans; D007038:Hypotonic Solutions; D015221:Potassium Channels; D011759:Pyrrolidines; C075012:rilmakalim; D020110:Pinacidil; D000255:Adenosine Triphosphate; D005905:Glyburide