[Biological properties study and animal experiment of polylactide/polytrimethylene carbonate blends membrane].
Polylactide is a biodegradable and biocompatible biomaterial. Based on the PLA (Polylactide) membrane, we have produced a new PLA/PTMC (Polytrimethylene carbonate) blends membrane. The biological properties of this membrane were studied by cell toxicity experiment, acute toxicity experiment, skin irritant experiment, sensitization test, hemolytic test, micronucleus test and subcutaneous implantation test. The results demonstrated that the blends membrane has no toxicity and it does not cause skin irritation, hypersensitive reaction and hemolysis. The micronucleus ratio of the membrane is 1.3% +/- 1.0%, being less than 3%. The result of medullary micronucleus test was reported negative. The wounds were free from suppuration and necrosis after subcutaneous implantation in all periods. In the experimental application of this member to preventing adhesion after rabbit intestine operation, the membrane demonstrated good effect. In conclusion, PLA/PTMC blends membrane is a material with good biocompatibility.
Yang
Xiaoqiang
X
Research Institute of Daily Chemistry of China, Taiyuan 030024, China. davis2218@163.com
Yuan
Minglong
M
Li
Wei
W
Zhang
Gaoyong
G
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D004146:Dioxanes / Q000737:chemistry*; D005260:Female; D007410:Intestinal Diseases / Q000517:prevention & control / Q000601:surgery; D008297:Male; D008422:Materials Testing; D008567:Membranes, Artificial; D051379:Mice; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D011897:Random Allocation; D000267:Tissue Adhesions / Q000517:prevention & control
D001672:Biocompatible Materials; D004146:Dioxanes; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; C059299:polytrimethylene carbonate; C033616:poly(lactide)