title: Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors.
abstract: Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.
authors.affiliation: Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shinlim-Dong, Seoul 151-742, Republic of Korea.
authors.lastname: Farhanullah
authors.forename: Su Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Eun-Jeong
authors.initials: EJ
authors.lastname: Yoon
authors.forename: Eung-Chil
authors.initials: EC
authors.lastname: Choi
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Kim
authors.forename: Taehee
authors.initials: T
authors.lastname: Kang
authors.forename: Farhana
authors.initials: F
authors.lastname: Samrin
authors.forename: Sadhna
authors.initials: S
authors.lastname: Puri
authors.forename: Jeewoo
authors.initials: J
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008718:Methionine-tRNA Ligase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D015363:Quinolones; D008718:Methionine-tRNA Ligase