title: Dimerization in protein kinase signaling.
abstract: The closely related mitogen-activated protein kinases ERK1 and ERK2 have now been shown to have opposing roles in Ras-mediated cell proliferation. I propose that dimerization of these highly related protein kinases could underlie these surprising observations and that this could be a common paradigm for widespread regulation of protein phosphorylation by kinase-substrate interactions.
authors.affiliation: The Brain Research Centre, Division of Neurology, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 2B5, Canada. spelech@kinexus.ca
authors.forename: Steven
authors.initials: S
authors.lastname: Pelech
mesh_terms: D000818:Animals; D019281:Dimerization; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D011494:Protein Kinases