Twice primed: cyclin E is phosphorylated and isomerized before being ubiquitinated.
Targeting proteins for irreversible degradation must be under tight control and is often regulated at the level of substrate-receptor binding. But does a protein really need to be marked twice with two different modifications, first phosphorylation and then isomerization, to bind its receptor, as van Drogen et al. (2006) show for cyclin E?
Shumway
Stuart D
SD
Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Xiong
Yue
Y
D018797:Cell Cycle Proteins / Q000378:metabolism; D019927:Cyclin E / Q000819:agonists* / Q000378:metabolism*; D044783:F-Box Proteins / Q000378:metabolism; D007536:Isomerism; D010766:Phosphorylation; D011485:Protein Binding; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism*
D018797:Cell Cycle Proteins; D019927:Cyclin E; D044783:F-Box Proteins; D014452:Ubiquitins; D044767:Ubiquitin-Protein Ligases