title: [A comparative study of the components of the antioxidant defense system during growth of the mycelium of a wild-type Neurospora crassa strain and mutants, white collar-1 and white collar-2].
abstract: A comparative study of the changes in the components of the antioxidant defense system (ADS), the activity of superoxide dismutase (SOD) and catalase and the level of extractable SH-groups, during the growth of wild-type and mutant (white collar-1 and white colar-2) Neurospora crassa strains was performed. Oxidative stress developing during spore germination and upon the transition to a stationary growth phase was accompanied in all strains by an increase in the level of extractable SH-groups and SOD activity, whereas the total catalase activity decreased during growth. However, in contrast to the wild-type strain, the activity of the catalase in the mutant strains wc-1 and wc-2 slightly increased upon the transition to the stationary phase. In the wc-2 mutant, SOD activity and the level of extractable SH-groups in the exponential growth phase were always lower than in the wild-type and wc-2 strains. The role of wc-1 and wc-2 genes in the level regulation of reactive oxygen species is discussed.
authors.forename: N N
authors.initials: NN
authors.lastname: Gessler
authors.forename: O A
authors.initials: OA
authors.lastname: Leonovich
authors.forename: Ia M
authors.initials: IaM
authors.lastname: Rabinovich
authors.forename: M N
authors.initials: MN
authors.lastname: Rudchenko
authors.forename: T A
authors.initials: TA
authors.lastname: Belozerskaia
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D005656:Fungal Proteins / Q000096:biosynthesis* / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D009154:Mutation; D009492:Neurospora crassa / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D018384:Oxidative Stress / Q000235:genetics; D010088:Oxidoreductases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000975:Antioxidants; D005656:Fungal Proteins; D010088:Oxidoreductases