title: A weighted logistic regression model for estimation of recurrence of adenomas.
abstract: In a colorectal polyp prevention trial, some participants might have their follow-up colonoscopy conducted before the scheduled time (i.e. at the end of the trial). This results in variable follow-up lengths for participants and the data of recurrence status at the end of the trial can be considered as current status data. In this paper, we use a weighted logistic regression model to estimate recurrence rate of adenoma data at the end of the trial. The weights are used to adjust for variable follow-up. We show that logistic regression tends to underestimate recurrence rate. In a simulation study, we show that Kaplan-Meier estimator derived from the right endpoint of the current status data tends to overestimate recurrence rate in contrast to logistic regression and the weighted logistic regression method can produce reasonable estimates of recurrence rate even under a high non-compliance rate compared to conventional logistic regression and Kaplan-Meier estimator. The method described here is illustrated with an example from a colon cancer study.
authors.affiliation: Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health and Arizona Cancer Center, University of Arizona, Tucson, AZ 85724-5024, USA. phsu@azcc.arizona.edu
authors.forename: Chiu-Hsieh
authors.initials: CH
authors.lastname: Hsu
authors.forename: Sylvan B
authors.initials: SB
authors.lastname: Green
authors.forename: Yulei
authors.initials: Y
authors.lastname: He
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control; D002756:Cholagogues and Choleretics / Q000494:pharmacology; D003111:Colonic Polyps / Q000473:pathology / Q000517:prevention & control; D003113:Colonoscopy / Q000592:standards; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control; D003198:Computer Simulation; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology* / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D016312:Treatment Refusal; D014580:Ursodeoxycholic Acid / Q000494:pharmacology
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid