Autophagy: a highway for Porphyromonas gingivalis in endothelial cells.
P. gingivalis, an important periodontal pathogen associated with adult periodontitis and a likely contributing factor to atherosclerosis and cardiovascular disease, traffics in endothelial cells via the autophagic pathway. Initially, P. gingivalis rapidly adheres to the host cell surface followed by internalization via lipid rafts and incorporation of the bacterium into early phagosomes. P. gingivalis activates cellular autophagy to provide a replicative niche while suppressing apoptosis. The replicating vacuole contains host proteins delivered by autophagy that are used by this asaccharolytic pathogen to survive and replicate within the host cell. When autophagy is suppressed by 3-methyladenine or wortmannin, internalized P. gingivalis transits to the phagolysosome where it is destroyed and degraded. Therefore, the survival of P. gingivalis depends upon the activation of autophagy and survival of the endothelial host cell, but the mechanism by which P. gingivalis accomplishes this remains unclear.
Bélanger
Myriam
M
Department of Oral Biology, College of Dentistry, Center for Molecular Microbiology, University of Florida, Gainesville, Florida 32610-0424, USA.
Rodrigues
Paulo H
PH
Dunn
William A
WA
Progulske-Fox
Ann
A
D000818:Animals; D001343:Autophagy / Q000502:physiology*; D016866:Bacteroidaceae Infections / Q000378:metabolism / Q000382:microbiology; D001692:Biological Transport; D002470:Cell Survival; D004730:Endothelium, Vascular / Q000166:cytology / Q000382:microbiology*; D006801:Humans; D050296:Microbial Viability; D008954:Models, Biological; D016966:Porphyromonas gingivalis / Q000472:pathogenicity*