title: Contribution of penicillin-binding protein homologs to antibiotic resistance, cell morphology, and virulence of Listeria monocytogenes EGDe.
abstract: Seven open reading frames, annotated as potential penicillin-binding-protein-encoding genes (lmo0441, lmo0540, lmo1438, lmo1892, lmo2039, lmo2229, and lmo2754), were targeted for insertional mutagenesis in Listeria monocytogenes EGDe. These genes were found to contribute in various degrees to beta-lactam resistance, cell morphology, or the virulence potential of this organism.
authors.affiliation: Department of Microbiology, University College Cork, Cork, Ireland.
authors.forename: Caitriona M
authors.initials: CM
authors.lastname: Guinane
authors.forename: Paul D
authors.initials: PD
authors.lastname: Cotter
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
mesh_terms: D000595:Amino Acid Sequence; D015169:Colony Count, Microbial; D005798:Genes, Bacterial; D008089:Listeria monocytogenes / Q000145:classification / Q000166:cytology* / Q000235:genetics* / Q000472:pathogenicity* / Q000648:ultrastructure; D008088:Listeriosis / Q000382:microbiology; D008969:Molecular Sequence Data; D008970:Molecular Weight; D016254:Mutagenesis, Insertional; D016366:Open Reading Frames; D046915:Penicillin-Binding Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D010406:Penicillins / Q000378:metabolism; D014774:Virulence / Q000235:genetics; D018440:beta-Lactam Resistance / Q000235:genetics
chemical_list: D046915:Penicillin-Binding Proteins; D010406:Penicillins