title: Analysis of a complex analgesic formulation by high-performance liquid chromatography with column-switching.
abstract: An isocratic method is described which allows the complete separation of acetylsalicylic acid, paracetamol, caffeine, carbromal, bromisoval and codeine as well as the potential impurities salicylic acid, diacetyl-p-aminophenol and acetylcodeine. A column-switching technique was developed employing two columns (10 cm and 25 cm) containing 7-microm Zorbax C(8) material. The separation is better and faster than that obtained with a gradient elution method.
authors.affiliation: Katholieke Universiteit Leuven, Instituut voor Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie, Van Evenstraat 4, B-3000 Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Cockaerts
authors.forename: E
authors.initials: E
authors.lastname: Roets
authors.forename: J
authors.initials: J
authors.lastname: Hoogmartens