title: Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: therapeutic challenges.
abstract: We present the first child case of pseudomembranous conjunctivitis accompanied by an extensive corneal ulcer with acute graft-versus-host disease (GVHD) after cord blood stem cell transplantation (CBSCT). The histopathology of the pseudomembrane and the ocular changes following its excision were investigated specifically. One week after the excision of pseudomembrane, the extensive corneal epithelial defects had totally disappeared. Pseudomembrane excision may be an effective method of treatment in corneal epithelial defects observed after GVHD.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Uchino
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Masataka
authors.initials: M
authors.lastname: Kawai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.forename: Kaori
authors.initials: K
authors.lastname: Kameyama
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Okamoto
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003231:Conjunctivitis / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D003320:Corneal Ulcer / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006086:Graft vs Host Disease / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy; D008297:Male; D013508:Ophthalmologic Surgical Procedures