title: In vitro activity of a new antibacterial rhodanine derivative against Staphylococcus epidermidis biofilms.
abstract: OBJECTIVE
  Staphylococcus epidermidis biofilms form at the surface of implants and prostheses and are responsible for the failure of many antibiotic therapies. Only a few antibiotics are relatively active against biofilms, and rifampicin, a transcription inhibitor, is among the most effective molecules for treating biofilm-related infections. Having recently selected a new potential transcription inhibitor, we attempted to evaluate its efficacy against S. epidermidis biofilms.
  
  
  METHODS
  Biofilm-forming S. epidermidis strains were grown planktonically or as biofilms and their susceptibility to this transcription inhibitor was compared with reference antibiotics with different mechanisms of action.
  
  
  CONCLUSIONS
  Our results demonstrate that this new molecule is active; its effects are fast and kinetically related to those of rifampicin, but unlike rifampicin it does not select for resistant bacteria.
authors.affiliation: CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé, Faculté de Pharmacie Montpellier, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Gualtieri
authors.forename: Lionel
authors.initials: L
authors.lastname: Bastide
authors.forename: Philippe
authors.initials: P
authors.lastname: Villain-Guillot
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michaux-Charachon
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Latouche
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Leonetti
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011137:Polystyrenes; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000254:growth & development; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011137:Polystyrenes; D012236:Rhodanine; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin