Graded ephrin-A2 expression in the developing hamster superior colliculus.
During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostral(low) to caudal (high) gradient that is most prominent at postnatal days P4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell specific markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury.
Lukehurst
Sherralee S
SS
School of Animal Biology M092, The University of Western Australia, Crawley, WA, Australia.
King
Carolyn E
CE
Beazley
Lyn D
LD
Tay
David K C
DK
So
Kwok-Fai
KF
Rodger
Jennifer
J
D000818:Animals; D001253:Astrocytes / Q000502:physiology; D002452:Cell Count; D006224:Cricetinae; D036383:Ephrin-A2 / Q000096:biosynthesis*; D019084:Fluorescent Antibody Technique, Indirect; D007150:Immunohistochemistry; D018613:Microscopy, Confocal; D012160:Retina / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000502:physiology; D013477:Superior Colliculi / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*
D036383:Ephrin-A2