Calcium influx: beyond 'current' biology.
A novel, cell-surface protein essential for Ca(2+) release-activated Ca(2+) (CRAC) channel function has been identified through independent genome-wide screens. This huge advance will enable molecular dissection of the CRAC channel complex, moving the field beyond Icrac signature to structure.
Robinson
Lisbeth C
LC
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 55455, USA.
Marchant
Jonathan S
JS
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics* / Q000378:metabolism; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D023281:Genomics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D005810:Multigene Family / Q000502:physiology; D009154:Mutation; D000071740:ORAI1 Protein; D034622:RNA Interference; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology
D015220:Calcium Channels; D029721:Drosophila Proteins; D008565:Membrane Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C510747:olf186-F protein, Drosophila; D002118:Calcium