title: Vaginal microbicides can interfere with nucleic acid amplification tests used for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae infection.
abstract: We confirmed findings from previous studies that cellulose sulfate gel can interfere with nucleic acid amplification tests used for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae. We therefore recommend that the effects of microbicide gels on diagnostic assays of sexually transmitted infections be established before starting up clinical studies.
authors.affiliation: HIV/STD Research and Intervention Unit, Institute of Tropical Medicine,155 Nationalestraat, 2000 Antwerp, Belgium. tcrucitti@itg.be
authors.forename: Tania
authors.initials: T
authors.lastname: Crucitti
authors.forename: Vicky
authors.initials: V
authors.lastname: Jespers
authors.forename: Lut
authors.initials: L
authors.lastname: Van Damme
authors.forename: Eddy
authors.initials: E
authors.lastname: Van Dyck
authors.forename: Anne
authors.initials: A
authors.lastname: Buvé
mesh_terms: D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000382:microbiology / Q000517:prevention & control; D002692:Chlamydia trachomatis / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005782:Gels; D006069:Gonorrhea / Q000175:diagnosis* / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000302:isolation & purification; D021141:Nucleic Acid Amplification Techniques / Q000592:standards; D013048:Specimen Handling / Q000379:methods; D014621:Vagina / Q000737:chemistry* / Q000382:microbiology
chemical_list: D005782:Gels; D002482:Cellulose; C020254:cellulose sulfate