Dissociation constants and assay of weak bases in non-aqueous solvents.
A method is described for evaluating standard cell potentials of specific electrode pair systems in anhydrous acetic acid and acetonitrile. The dissociation constants (K(HB+)) in acetonitrile and the overall dissociation constants (K(B)) and (K(BHClO4)) in anhydrous acetic acid of a series of bases of pharmaceutical interest have been determined. Simple potentiometric and visual titration methods are proposed for the assay of bases and their mixtures.
Barbosa
J
J
Department of Analytical Chemistry, University of Barcelona, Barcelona, Spain.
Barron
D
D
Beneyto
J E
JE
Sanz-Nebot
V
V