Dermal templates and the wound-healing paradigm: the promise of tissue regeneration.
Dermal regeneration templates arguably represent the first and most clinically successful 'tissue engineering' solution designed for organ reconstruction. Wound healing in the skin normally occurs on a continuum. At one extreme of the continuum lies the promise of tissue regeneration and the complete restoration of normal structure and function. Unfortunately, in the adult, all too often, wound healing occurs at the other extreme of the continuum and the dermis is reconstituted as scar tissue. Dermal regeneration templates are designed to manage the wound-healing process and tip the scales toward regeneration. This review discusses the architecture and molecular composition of the skin and the events that mediate wound healing and scar formation. The development, evolution and commercialization of dermal templates are examined and the clinical and business considerations that drive the product-development cycle are discussed. In the near term, dermal templates cannot be expected to dramatically change in overall composition. Product development will be dominated by continued refinements of existing templates and the field of use will continue to expand as manufacturers seek to increase revenue and capture market share. Continued exploration of novel processing strategies, such as electrospinning, that can be used to fabricate nanoscale biomaterials, may provide a gateway to the next generation of dermal templates.
Simpson
David G
DG
Virginia Commonwealth University, Department of Anatomy & Neurobiology, Richmond, VA 23298-0709, USA. dgsimpso@vcu.edu
D000818:Animals; D002921:Cicatrix / Q000473:pathology; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D012867:Skin / Q000473:pathology*; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing / Q000502:physiology*