title: Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model.
abstract: Herein we describe a small-molecule, non-peptidic, inhibitor for botulinum neurotoxin A protease, that displays for the first time efficacy in a cell-based assay.
authors.affiliation: Department of Chemistry and Immunology, Skaggs Institute for Chemical Biology, Worm Institute for Research Medicine (WIRM), Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Grant E
authors.initials: GE
authors.lastname: Boldt
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Eubanks
authors.forename: Kim D
authors.initials: KD
authors.lastname: Janda
mesh_terms: D000818:Animals; D001681:Biological Assay; D019274:Botulinum Toxins, Type A / Q000037:antagonists & inhibitors*; D051379:Mice; D009447:Neuroblastoma / Q000201:enzymology* / Q000473:pathology; D009498:Neurotoxins / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D009498:Neurotoxins; D011480:Protease Inhibitors; D019274:Botulinum Toxins, Type A