title: Health-related quality of life outcome after on-pump versus off-pump coronary artery bypass graft surgery: a prospective randomized study.
abstract: BACKGROUND
  The clinical benefit of off-pump coronary artery bypass graft surgery over on-pump surgery is a matter of controversy. The aim of this study was to assess quality of life in patients after on-pump and off-pump coronary artery bypass graft surgery, and compare the data with an age-matched and sex-matched standard population.
  
  
  METHODS
  Two hundred twelve patients admitted for elective coronary artery bypass graft surgery were randomized to on-pump (n = 104) and off-pump (n = 108) surgery. Quality-of-life assessments were made 6 and 18 months postoperatively using the standard form of the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36, version 2). The questionnaire yields eight subscores of functional health and well being. The eight SF-36 raw scores were standardized using means and standard deviations from a random sample of adults in Great Britain. Mean on-pump and off-pump SF-36 scores were compared using two-sample Student's t tests.
  
  
  RESULTS
  Questionnaires were completed for 72% (154 of 212) and 46% (98 of 212) of patients at the 6- and 18-month follow-up, respectively. There were no significant differences between on-pump and off-pump patients in any of the eight subscales at both stages. Fifty-six (72%) on-pump and 59 (75%) off-pump patients reported a better health status compared with the 6-month period before surgery (not significant).
  
  
  CONCLUSIONS
  Patients who have undergone off-pump coronary artery bypass graft surgery have a similar quality of life to on-pump patients at 6 and 18 months after surgery. For both groups, the majority of patients reported improved health after coronary artery bypass graft surgery compared with their preoperative status.
authors.affiliation: Department of Cardiac Surgery, St. George's Hospital Medical School, London, United Kingdom.
authors.forename: Reza
authors.initials: R
authors.lastname: Motallebzadeh
authors.forename: J Martin
authors.initials: JM
authors.lastname: Bland
authors.forename: Hugh S
authors.initials: HS
authors.lastname: Markus
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Kaski
authors.forename: Marjan
authors.initials: M
authors.lastname: Jahangiri
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass / Q000523:psychology*; D047549:Coronary Artery Bypass, Off-Pump / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life