title: Chorea induced by globus pallidus externus stimulation in a dystonic patient.
abstract: Bilateral high-frequency stimulation of the internal part of the pallidum has proven its efficacy in improving motor symptoms of dystonia. In Parkinson's disease, the stimulation of the external pallidum (GPe) can induce dyskinesias. This has never been described in dystonia. We report here a case of abnormal movements induced by the stimulation of GPe in a dystonic patient and discuss the pathophysiological mechanisms.
authors.affiliation: Service de Neurologie C, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Claude Bernard Lyon I University, INSERM U 534, Lyon, France.
authors.forename: Servane
authors.initials: S
authors.lastname: Mouton
authors.forename: Jing
authors.initials: J
authors.lastname: Xie-Brustolin
authors.forename: Patrick
authors.initials: P
authors.lastname: Mertens
authors.forename: Gustavo
authors.initials: G
authors.lastname: Polo
authors.forename: Philippe
authors.initials: P
authors.lastname: Damier
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Broussolle
authors.forename: Stéphane
authors.initials: S
authors.lastname: Thobois
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D002819:Chorea / Q000209:etiology* / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D004292:Dominance, Cerebral / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000628:therapy*; D004421:Dystonia / Q000139:chemically induced* / Q000628:therapy*; D004567:Electrodes, Implanted; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents