title: The yjeQ gene is required for virulence of Staphylococcus aureus.
abstract: Gene products required for in vivo growth and survival of Staphylococcus aureus and other pathogens represent new targets for antimicrobial chemotherapy. In this study we created a Staphylococcus aureus yjeQ deletion strain and tested its virulence using a mouse kidney abscess infection model. The yjeQ deletion strain was compromised for growth in vitro and severely attenuated for virulence. We concluded that yjeQ is an attractive and novel new drug target.
authors.affiliation: Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5.
authors.forename: Tracey L
authors.initials: TL
authors.lastname: Campbell
authors.forename: James
authors.initials: J
authors.lastname: Henderson
authors.forename: David E
authors.initials: DE
authors.lastname: Heinrichs
authors.forename: Eric D
authors.initials: ED
authors.lastname: Brown
mesh_terms: D000038:Abscess / Q000382:microbiology / Q000473:pathology*; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D020558:GTP Phosphohydrolases / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D006801:Humans; D007674:Kidney Diseases / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D020558:GTP Phosphohydrolases