Favorable entropy of aromatic clusters in thermophilic proteins.
Aromatic clusters, found with increased frequency in a set of thermophilic proteins, confer an entropic advantage over mesophilic analogues through introduction of large-amplitude oscillations; this is a source of improved free energy at high temperatures.
Trebbi
Bruno
B
Dipartimento di Chimica G. Ciamician, Università di Bologna, via F. Selmi 2, 40126 Bologna, Italy.
Dehez
Francois
F
Fowler
Patrick W
PW
Zerbetto
Francesco
F
D000595:Amino Acid Sequence; D024322:Amino Acids, Aromatic / Q000737:chemistry*; D002151:Calorimetry; D019277:Entropy; D004798:Enzymes / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D013816:Thermodynamics
D024322:Amino Acids, Aromatic; D004798:Enzymes; D011506:Proteins