title: Catch the kinase conformer.
abstract: Protein kinases exist in inactive and active states, but little attention has been paid to which state is or should be the target in drug discovery efforts. In this issue of Chemistry & Biology, Okram et al. tackle this issue and show that inhibitors can be designed specifically to bind to inactive Abl.
authors.affiliation: College of Pharmacy, University of South Carolina, Columbia, 29208, USA.
authors.forename: Campbell
authors.initials: C
authors.lastname: McInnes
authors.forename: Mokdad
authors.initials: M
authors.lastname: Mezna
authors.forename: George
authors.initials: G
authors.lastname: Kontopidis
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D011487:Protein Conformation; D011494:Protein Kinases / Q000737:chemistry*
chemical_list: D011494:Protein Kinases