[Increased use of sodium chloride modulates the diuretic effect of enalapril in intact rats and in rats with model edema syndrome].
Experiments on rats showed that the increased use of NaCl modulates the renal activity of enalapril. In animals with a model edema syndrome caused by subdiaphragm constriction of the interior vena cava, a hyper-NaCl diet enhances the Na-diuretic action of enalapril in both subacute and chronic stage of circulation insufficiency. In addition, enalapril increases the creatinin secretion in rats with this model (but not in intact animals). The administraton of enalapril in animals with caval obstruction receiving excess NaCl, in contrast to the case of standard diet, decreases the consumption of water, thus preventing the development of a positive balance of water.
Shtrygol'
S Iu
SIu
Shumakova
V A
VA
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D003404:Creatinine / Q000652:urine; D004195:Disease Models, Animal; D004232:Diuretics / Q000008:administration & dosage*; D004326:Drinking / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004656:Enalapril / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017673:Sodium Chloride, Dietary / Q000009:adverse effects / Q000494:pharmacology; D013577:Syndrome; D014682:Vena Cava, Inferior / Q000473:pathology; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D000959:Antihypertensive Agents; D004232:Diuretics; D017673:Sodium Chloride, Dietary; D004656:Enalapril; D003404:Creatinine