title: Genetic polymorphisms of vascular endothelial growth factor and angiopoietin 2 in retinopathy of prematurity.
abstract: Angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2) contribute to development of retinopathy of prematurity (ROP). We aimed to test whether polymorphisms of these factors are associated with ROP. VEGF(-2578) and Ang2(-35) polymorphisms were analyzed with PCR-RFLP method in 200 preterm infants without ROP or with ROP stages 1-5. Our results suggest that there is no association between carrier state of VEGF(-2578) and Ang2(-35) and risk of ROP in preterm infants. The prevalence of VEGF(-2578) "A" allele was lower in preterm boys with severe ROP (stages 4-5) than in those without or with mild ROP (stages 1-3).
authors.affiliation: 1st Department of Paediatrics, Semmelweis University, Budapest, Hungary. banyasz@gyer1@sote.hu
authors.forename: Ilona
authors.initials: I
authors.lastname: Bányász
authors.forename: Géza
authors.initials: G
authors.lastname: Bokodi
authors.forename: Adám
authors.initials: A
authors.lastname: Vannay
authors.forename: Beáta
authors.initials: B
authors.lastname: Szebeni
authors.forename: András
authors.initials: A
authors.lastname: Treszl
authors.forename: Barna
authors.initials: B
authors.lastname: Vásárhelyi
authors.forename: Tivadar
authors.initials: T
authors.lastname: Tulassay
authors.forename: András
authors.initials: A
authors.lastname: Szabó
mesh_terms: D000483:Alleles; D042702:Angiopoietin-2 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012178:Retinopathy of Prematurity / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042702:Angiopoietin-2; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D004247:DNA