Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker.
From the leaves of Phellolophium madagascariense Baker (Apiaceae), an endemic herb to Madagascar, three known coumarins (osthol, murraol and meranzin hydrate) have been isolated and identified. This is the first report of these compounds in this species. The structural elucidations were based on the analysis of physical and spectroscopic data. The anticancer activity of the three isolated compounds and of a synthetic sample of osthol was evaluated on L1210 mouse leukemia and on human prostatic cancer hormonosensitive LNCaP and hormonoindependent PC3 and DU145 cell lines.
Riviere
C
C
Institut de Chimie Pharmaceutique Albert Lespagnol, EA2692, rue J. Laguesse, BP 83, F-59006 Lille, France.
Goossens
L
L
Pommery
N
N
Fourneau
C
C
Delelis
A
A
Henichart
J P
JP
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D018515:Plant Leaves / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins