[Effect of low-dose irradiation on the lifespan in various strains of Drosophila melanogaster].
Drosophila melanogaster strains defective in repair, antioxidant defense, and apoptosis displayed a higher aging rate than the wild-type strains when unexposed to ionizing radiation. Irradiation changed the lifespan depending on the genotype. The lifespan and the functional (neuromuscular) activity, which reflects the "life quality", changed in the same direction. A mechanism was suggested for the remote effect of low-dose irradiation on the lifespan. Since cells with a weakened defense system accumulate lesions and age at a higher rate, their elimination in early ontogeny decelerates age-related changes and decreases the aging rate. In subsequent generations, this somatic stress response (hormesis) is replaced by negative genetic effects at the population level and, consequently, the lifespan decreases.
Moskalev
A A
AA
Iatskiv
A S
AS
Zaĭnullin
V G
VG
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology / Q000528:radiation effects; D005260:Female; D008136:Longevity / Q000528:radiation effects; D008297:Male; D009154:Mutation; D013045:Species Specificity; D013482:Superoxide Dismutase / Q000235:genetics
D013482:Superoxide Dismutase