DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children.
In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.
Milanese
Michele
M
Department of Developmental and Reproductive Sciences, University of Trieste, Trieste, Italy.
Segat
Ludovica
L
Pontillo
Alessandra
A
Arraes
Luiz Claudio
LC
de Lima Filho
José Luiz
JL
Crovella
Sergio
S
D000293:Adolescent; D000890:Anti-Infective Agents; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D007223:Infant; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D023083:beta-Defensins / Q000235:genetics*
D000890:Anti-Infective Agents; C406407:DEFB1 protein, human; D005819:Genetic Markers; D023083:beta-Defensins