title: [Preparation and biological evaluation of Chitin short fiber reinforced polycaprolactone composite].
abstract: Chitin short fiber reinforced polycaprolactone composite was prepared by melting blending method. The cytotoxicity and biocompatibility of pure polycaprolactone and of chitin short fiber reinforced polycaprolactone composite were investigated in order to provide useful scientific basis for clinical application. The biocompatibility of pure polycaprolactone and that of chitin short fiber reinforced polycaprolactone composite were evaluated by a series of tests, including cytotoxicity test in vitro, acute systemic toxicity test, hemolysis test, pyrogen test and sensitivity test. The results showed that the cytotoxicity scores of the two materials were grade 0 and the growth and proliferation of the cultured cells were not significantly inhibited by the two materials. There were no potential allergic materials in the composites and the maceration extract showed no hemolytic reaction, no acute systemic toxicity and no pyrogen reaction. We conclude that the composites have fine biocompatibility and are safe for clinical use in the reconstruction treatment for chest wall defect.
authors.affiliation: Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. duan-liang@sohu.com
authors.forename: Liang
authors.initials: L
authors.lastname: Duan
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Xu
authors.forename: Kang
authors.initials: K
authors.lastname: Sun
authors.forename: Xuewei
authors.initials: X
authors.lastname: Zhao
authors.forename: Jia
authors.initials: J
authors.lastname: Fang
authors.forename: Xiong
authors.initials: X
authors.lastname: Qin
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Gong
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D002686:Chitin / Q000737:chemistry*; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; D002686:Chitin; C016240:polycaprolactone