Is leptin related to systemic inflammatory response in acute pancreatitis?
OBJECTIVE
To evaluate the relationship between leptin and systemic inflammation in acute pancreatitis.


METHODS
Consecutive patients with acute pancreatitis were included. Body mass index and serum samples were obtained at admission. Leptin, TNF-alpha, IL-6, -8 and -10 levels were determined by ELISA. Severity was defined according to Atlanta criteria.


RESULTS
Fifty-two (29 females) patients were studied. Overall body mass index was similar between mild and severe cases, although women with severe pancreatitis had lower body mass index (P = 0.04) and men showed higher body mass index (P = 0.05). No difference was found in leptin levels regarding the severity of pancreatitis, but higher levels tended to appear in male patients with increased body mass index and severe pancreatitis (P = 0.1). A multivariate analysis showed no association between leptin levels and severity. The strongest cytokine associated with severity was IL-6. Correlations of leptin with another cytokines only showed a trend for IL-8 (P = 0.058).


CONCLUSIONS
High body mass index was associated with severity only in males, which may be related to android fat distribution. Serum leptin seems not to play a role on the systemic inflammatory response in acute pancreatitis and its association with severe outcome in males might represent a marker of increased adiposity.
Duarte-Rojo
Andrés
A
Department of Internal Medicine, Vasco de Quiroga 15, Sección XVI, Tlalpan, CP 14000, México, DF, México.
Lezama-Barreda
Ana
A
Ramirez-Iglesias
María Teresa
MT
Peláez-Luna
Mario
M
Robles-Díaz
Guillermo
G
D000208:Acute Disease; D050154:Adiposity / Q000502:physiology; D000328:Adult; D015992:Body Mass Index; D018450:Disease Progression; D005260:Female; D006801:Humans; D007249:Inflammation; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D020738:Leptin / Q000097:blood* / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D011379:Prognosis; D012720:Severity of Illness Index; D012727:Sex Characteristics; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015850:Interleukin-6; D016209:Interleukin-8; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10