title: A simple predictive model for postoperative mortality after head and neck cancer surgery with opening of mucosa.
abstract: The aim of this study was to determine the risk factors for the mortality during the first 30 days after a major head and neck cancer surgery. Two hundred and sixty one consecutive surgical procedure were prospectively studied at Oscar Lambret Cancer Centre within a 36-months period. Twenty variables were recorded for each patient. The significant risk factors for postoperative mortality were assessed by univariate and multivariate analysis. Overall 30-days mortality rate was 3.83% [95% CI 3.13-4.53]. In univariate analysis identified four risk factors: female gender (odd ratio 4.25 [95% CI 1.03-17.56]), age equal or superior than 70 (odd ratio 5.06 [95% CI 1.35-18.36]), current alcohol addiction (odd ratio 3.65 [1.02-13.06]) and laryngeal location (odd ratio 4.23 [CI 95% 1.18-3.38]). In multivariate analysis only female gender and laryngeal location remained significant. The incidence of postoperative mortality was 1.63% for patients without risk factor and was 6.41% for those with one or two risk factors. This model identifies easily high-risk patients for major head and neck cancer surgery. A multicenter validation is necessary.
authors.affiliation: General Oncology Department, Oscar Lambret Centre, 3 rue F. Combemale, Lille 59020 BP 207, France. n-penel@o-lambret.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Penel
authors.forename: Eric Yaovi
authors.initials: EY
authors.lastname: Amela
authors.forename: Yann
authors.initials: Y
authors.lastname: Mallet
authors.forename: Danièle
authors.initials: D
authors.lastname: Lefebvre
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Clisant
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kara
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Neu
authors.forename: Frédéric
authors.initials: F
authors.lastname: Everard
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Lefebvre
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D004812:Epidemiologic Methods; D005260:Female; D006258:Head and Neck Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D016896:Treatment Outcome