title: Cytomegalovirus and BK-Virus co-infection of a clinically non-functioning adrenal adenoma: innocent bystanders or new pathogenetic agents?
abstract: We report a case of a 64-year-old woman who underwent left adrenalectomy with removal of a 8,5 cm clinically non-functioning adrenocortical adenoma and a 4-cm myelolipoma. Molecular testing for viral infection demonstrated the presence of cytomegalovirus (CMV) DNA sequences in the adrenal adenoma, but not in the myelolipoma (confirmed by immunohistochemistry). Moreover, the adrenal adenoma was also positive for parvovirus B19, and both adrenal tumor samples were positive for polyomavirus BK (BKV) and adenovirus DNA sequences. This is the first report of co-infection of an adrenocortical adenoma by CMV and BKV. The role of these viruses in adrenal tumorigenesis was postulated.
authors.forename: G
authors.initials: G
authors.lastname: Pomara
authors.forename: F
authors.initials: F
authors.lastname: Cappello
authors.forename: L
authors.initials: L
authors.lastname: Barzon
authors.forename: G
authors.initials: G
authors.lastname: Morelli
authors.forename: F
authors.initials: F
authors.lastname: Rappa
authors.forename: L
authors.initials: L
authors.lastname: Benvegna
authors.forename: G
authors.initials: G
authors.lastname: Giannarini
authors.forename: G
authors.initials: G
authors.lastname: Palù
authors.forename: C
authors.initials: C
authors.lastname: Selli
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000601:surgery / Q000821:virology; D000315:Adrenalectomy; D018246:Adrenocortical Adenoma / Q000473:pathology* / Q000821:virology; D001739:BK Virus / Q000235:genetics* / Q000302:isolation & purification; D003587:Cytomegalovirus / Q000235:genetics* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D018209:Myelolipoma / Q000235:genetics / Q000473:pathology; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000150:complications*