A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida.
Investigation of an acetone extract from Asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappaB-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.
Appendino
Giovanni
G
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy. appendino@pharm.unipmn.it
Maxia
Lucia
L
Bascope
Marcelo
M
Houghton
Peter J
PJ
Sanchez-Duffhues
Gonzalo
G
Muñoz
Eduardo
E
Sterner
Olov
O
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003106:Colon / Q000187:drug effects; D005309:Ferula / Q000737:chemistry*; D007194:India; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D010946:Plants, Medicinal / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016328:NF-kappa B; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; C513463:fetidone A; C513464:fetidone B