title: [A molecular epidemiological study on human plague fulminant epidemic in Qinghai, 2004].
abstract: OBJECTIVE
  To study the epidemiology of genotyping Yersinia pestis isolated in the fulminant epidemics of human plague in Qinghai province in 2004.
  
  
  METHODS
  Primer pairs targeting the twenty-three different identified regions (DFRs) were designed to detect the presence or deletion of each DFR in 13 strains of Yersinia pestis isolated from the fulminant epidemic of human plague in Qinghai province in 2004.
  
  
  RESULTS
  There were 4 genomovars, i.e. Genomovar 8, 10, 15 and 16 in the 13 strains of Yersinia pestis identified. The genomovar of all the strains of Yersinia pestis isolated from Nangqian county was Genomovar 10. Among the two strains of Yersinia pestis isolated from Wulan county, the genomovar of one strain was Genomovar 8 and the other was Genomovar 10. The genomovars of all the strains of Yersinia pestis isolated from Qilian, Qumalai and Chengduo county belonged to Genomovar 16.
  
  
  CONCLUSIONS
  It was demonstrated that the genotyping of Yersinia pestis appeared to be a powerful tool for investigating human plague epidemics.
authors.affiliation: Qinghai Provincial Institute for Endemic Disease Prevention and Control, Xining 811602, China.
authors.forename: Zhi-zhen
authors.initials: ZZ
authors.lastname: Qi
authors.forename: Er-hei
authors.initials: EH
authors.lastname: Dai
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Zhou
authors.forename: Yong-hai
authors.initials: YH
authors.lastname: Yang
authors.forename: Shou-hong
authors.initials: SH
authors.lastname: Yu
authors.forename: Rui-xia
authors.initials: RX
authors.lastname: Dai
authors.forename: Hai-hong
authors.initials: HH
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Rui-fu
authors.initials: RF
authors.lastname: Yang
mesh_terms: D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D010930:Plague / Q000453:epidemiology*; D015010:Yersinia pestis / Q000235:genetics* / Q000302:isolation & purification