Applications of X-ray diffractometric techniques in the analysis of drugs.
The principles underlying the diffraction of X-rays by crystals and the strategy of determining crystal structure are discussed; special attention is given to results obtained by X-ray crystallography. Examples illustrate how detailed study of the topographical characteristics of drug molecules of a particular pharmacological class may furnish a set of structural parameters that are helpful in understanding a given pharmacological response.
De Ranter
C J
CJ
Lab. Anal. Chemie en Medicinale Fysicochemie, Inst. Farm. Wet., K.U. Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium.