title: Inverted ductal papilloma of minor salivary gland: case report with immunohistochemical study and literature review.
abstract: Inverted ductal papilloma (IDP) is a type of ductal papilloma arising in ducts of minor salivary glands. Very few cases, and no cases in Japan, have been reported. Reported herein is a case of IDP with a review of the literature. The patient was a 49-year-old man presenting with a lump in the right buccal mucosa of the premolar area of the mandible. The tumor was excised en bloc after a biopsy diagnosis of IDP. On the surface of the covering epithelium, an opening was seen to be filled with mucinous material. On cut surface the opening led to the tumor cavity. The major portion of the tumor parenchyma was made up of papillary proliferation of basaloid squamous cells. Some crypts, microcysts, and mucous cells were seen. There were no findings suggestive of a malignant tumor. The patient's postoperative course was uneventful and there has been no recurrence after 1 year's follow up. Immunohistochemical analysis of the present case supports the hypothesis that IDP originates from squamous metaplasia and proliferation of minor salivary gland duct cells.
authors.affiliation: Department of Diagnostic Pathology, Kanagawa Dental College Hospital, Yokosuka, Japan. nobunobu@kdcnet.ac.jp
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Kubota
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawai
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mizunuma
authors.forename: Ushaku
authors.initials: U
authors.lastname: Lee
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Konishi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Eiro
authors.initials: E
authors.lastname: Kubota
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000737:chemistry / Q000473:pathology; D018396:Mucin-1 / Q000032:analysis; D018308:Papilloma, Inverted / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018987:Salivary Ducts / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012470:Salivary Glands, Minor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1; D007633:Keratins