title: Interferon alpha in the establishment of latency by herpes simplex virus type 1 strain tr.
abstract: The effect of interferon (IFN) alpha on the establishment and maintenance of neuronal latency and viral reactivation is still not known. Using cell culture methods and sensitive RT-PCR methods, we show that the presence of antiserum to IFN alpha promotes the establishment of HSV-1 tr latent infection. We suggest that IFN alpha is an important tool not only for the control of productive but also latent HSV-1 infection.
authors.affiliation: National Institute of Hygiene, Department of Virology, Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Wieczorek
authors.forename: Bogumiła
authors.initials: B
authors.lastname: Litwińska
mesh_terms: D000818:Animals; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000378:metabolism; D016898:Interferon-alpha / Q000276:immunology*; D009474:Neurons / Q000821:virology*; D016716:PC12 Cells; D051381:Rats; D013937:Thymidine Kinase / Q000378:metabolism; D010948:Viral Plaque Assay / Q000379:methods; D017735:Virus Latency / Q000235:genetics / Q000276:immunology*
chemical_list: C057120:ICP27 protein, human herpesvirus 1; D017874:Immediate-Early Proteins; D016898:Interferon-alpha; D013937:Thymidine Kinase