[Resolution of alpha-cyclohexyl mandelic acid enantiomers by enantioselective extraction in separation system containing tartaric esters and beta-cyclodextrin].
OBJECTIVE
To establish a resolution method for alpha-cyclohexyl mandelic acid enantiomers by enantioselective extraction and to observe the effects of all kinds of tartaric esters, pH, the concentration of D-tartaric esters and beta-cyclodextrin on the enantioselectivity.


METHODS
Resolution of alpha-cyclohexyl mandelic acid enantiomers by enantioselective extraction with tartaric esters and beta-cyclodextrin has been studied.


RESULTS
The distribution behavior of alpha-cyclohexyl mandelic acid enantiomers in the separation system was studied. The effects of all kinds of tartaric esters, pH, the concentration of D-tartaric esters and beta-cyclodextrin on the enantioselectivity has been examined in the two-phase.


CONCLUSIONS
Results showed that the complex formed by D-iso-butyl-D-tartaric ester with R enantiomer is stabler than that with S enantiomer. With the increase of pH, the partition coefficient and separation factor decreased. The concentration of beta-cyclodextrin and D-tartaric ester had visible effect on the enantioselectivity.
Liu
Jia-jia
JJ
College of Chemistry and Chemical Engineering, Central South University, Changsha, China.
Zhou
Dan
D
Tang
Ke-wen
KW
D004952:Esters; D008333:Mandelic Acids / Q000737:chemistry*; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D004952:Esters; D008333:Mandelic Acids; D013644:Tartrates; D047392:beta-Cyclodextrins