Autophagy in immune defense against Mycobacterium tuberculosis.
Autophagy is a newly recognized innate and adaptive immunity defense against intracellular pathogens, in keeping with its role as a cytoplasmic maintenance pathway. Induction of autophagy by physiological, pharmacological or immunological means can eliminate intracellular Mycobacterium tuberculosis, providing one of the first examples of the immunological role of autophagy. Under normal circumstances, M. Tuberculosis survives in macrophages by inhibiting phagolysosome biogenesis. Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated.
Vergne
Isabelle
I
Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-001, USA. vderetic@salud.unm.edu
Singh
Sudha
S
Roberts
Esteban
E
Kyei
George
G
Master
Sharon
S
Harris
James
J
de Haro
Sergio
S
Naylor
John
J
Davis
Alex
A
Delgado
Monica
M
Deretic
Vojo
V
D001343:Autophagy / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000502:physiology; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology; D008055:Lipids / Q000502:physiology; D008264:Macrophages / Q000382:microbiology; D050296:Microbial Viability; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity*; D010587:Phagocytosis / Q000502:physiology; D010588:Phagosomes / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000096:biosynthesis; D018418:Th2 Cells / Q000378:metabolism / Q000502:physiology; D014376:Tuberculosis / Q000276:immunology*
D016207:Cytokines; D008055:Lipids; D018129:Phosphatidylinositol Phosphates; C055525:phosphatidylinositol 3-phosphate; D007371:Interferon-gamma; D020558:GTP Phosphohydrolases