title: Post traumatic epilepsy: a review of scientific evidence.
abstract: Post traumatic epilepsy is the development of recurrent seizures following head trauma and has a high clinical relevance. Several risk factors including some genetic factors increase the susceptibility of post traumatic epilepsy. The precise mechanisms of epileptogenesis in post-traumatic epilepsy are still poorly understood. Many structural, physiologic and biochemical changes in the brain may account for epileptogenesis. The reactive oxygen species (ROS), especially *OH and excitotoxicity are primarily involved. Antioxidants, like tocopherol, antiepileptic drug zonisamide, condensed tannins, melatonin, adenosine, trans-resveratrol, and some other agents have been proposed to prevent epileptogenic focus formation. The review also discusses various aspects of post traumatic epilepsy, mechanisms of epileptogenesis, and clinical implications.
authors.affiliation: Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029. yk.ykgupta@gmail.com
authors.forename: Y K
authors.initials: YK
authors.lastname: Gupta
authors.forename: Madhur
authors.initials: M
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D001923:Brain Chemistry; D004834:Epilepsy, Post-Traumatic / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D000927:Anticonvulsants; D000975:Antioxidants; D017382:Reactive Oxygen Species