Selenoprotein W during development and oxidative stress.
Selenium is involved in prevention of cancer, heart and muscle diseases, is implicated in immune function, fertility and in delaying the aging process. Selenium deficiency is harmful to brain, heart and skeletal muscles. Selenoprotein W, a member of the selenoprotein family was expressed in developing nervous system, skeletal muscles and heart in mice. Selenoprotein W was highly expressed in proliferating myoblasts and less or not in differentiated myotubes. Selenoprotein W exhibited an immediate response to oxidative stress in proliferating myoblasts, after exposure to hydrogen peroxide, similar to gluteraldehyde-3-phosphate dehydrogenase. We suggest that Selenoprotein W is involved in muscle growth and differentiation by protecting the developing myoblasts from oxidative stress.
Loflin
John
J
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, 97331, USA.
Lopez
Nathan
N
Whanger
Phil D
PD
Kioussi
Chrissa
C
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005775:Gastrula / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006861:Hydrogen Peroxide / Q000494:pharmacology; D051379:Mice; D024510:Muscle Development / Q000235:genetics; D032448:Myoblasts, Skeletal / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress; D051151:Selenoprotein W / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism*
D051151:Selenoprotein W; D006861:Hydrogen Peroxide