title: Human polymorphism around recombination hotspots.
abstract: Meiotic recombination in humans is thought to occur as part of the resolution of DSBs (double-strand breaks). The repair of DSBs potentially leads to biases in DNA repair that can distort the population frequency of the alleles at single-nucleotide polymorphisms. Genome-wide variation data provide evidence for a weak fixation bias in favour of G and C alleles that is strongest at the centre of inferred recombination hotspots.
authors.affiliation: Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX13TG, UK. spencer@stats.ox.ac.uk
authors.forename: C C A
authors.initials: CC
authors.lastname: Spencer
mesh_terms: D000483:Alleles; D006801:Humans; D008540:Meiosis; D009154:Mutation / Q000235:genetics; D009711:Nucleotides / Q000235:genetics; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic / Q000235:genetics*
chemical_list: D009711:Nucleotides