Hyperinols A and B, chymotrypsin inhibiting triterpenes from Hypericum oblongifolium.
Hyperinols A (1) and B (2) are new taraxastane type triterpenes which have been isolated from the chloroform soluble fraction of Hypericum oblongifolium and their structures elucidated on the basis of spectroscopic data. Both showed significant inhibitory activity against chymotrypsin enzyme.
Ferheen
Sadia
S
Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex, Karachi-75280, Pakistan.
Ahmed
Ejaz
E
Malik
Abdul
A
Afza
Nighat
N
Lodhi
Muhammad Arif
MA
Choudhary
Muhammad Iqbal
MI
D002725:Chloroform / Q000737:chemistry; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000494:pharmacology*
C513990:3,22-dihydroxy-20(30)-taraxastane-28,13-olide; C513989:3-hydroxy-20(30)-taraxastene-28,13-olide; D012996:Solutions; D014315:Triterpenes; D014361:Trypsin Inhibitors; D002725:Chloroform; D002918:Chymotrypsin