title: Synthesis of potential biologically active 1,2-benzothiazin-3-yl-quinazolin-4(3H)-ones.
abstract: A series of potential biologically active 2-(4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)quinazolin-4(3H)-ones was synthesized in a straight forward manner by condensation of respective 4-hydroxy-1,2-benzothiazine-1,1-dioxides with anthranilamide followed by simple and high throughput cyclization of N-[2-(aminocarbonyl)phenyl]-4-hydroxy-1,2-benzothiazine-3-carboxamide-1,1-dioxides. All the synthesized compounds were subjected to preliminary evaluation for their biological activity against Gram positive and Gram negative bacteria. Some of the assayed compounds showed marked activity against Bacillus subtilis.
authors.affiliation: Applied Chemistry Research Center, PCSIR Laboratories Complex, Lahore-54600, Pakistan. rehman_pcsir@hotmail.com
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zia-ur-Rehman
authors.forename: Jamil Anwar
authors.initials: JA
authors.lastname: Choudary
authors.forename: Saeed
authors.initials: S
authors.lastname: Ahmad
authors.forename: Hamid Latif
authors.initials: HL
authors.lastname: Siddiqui
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D062367:ortho-Aminobenzoates / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D011799:Quinazolines; D013843:Thiazines; D062367:ortho-Aminobenzoates; C000219:anthranilamide