Iridoids from Neopicrorhiza scrophulariiflora and their hepatoprotective activities in vitro.
Four new non-glycosidic iridoids, piscrocins D (1), E (2), F (6), and G (7), as well as two new iridoid glycosides, piscrosides A (8) and B (9), were isolated from the roots of Neopicrorhiza scrophulariiflora (Scrophulariaceae), together with seven known iridoids. The structures of the isolated compounds were established by means of 1D and 2D NMR spectroscopy and chemical methods. The hepatoprotective activities of these compounds were evaluated by measuring their effects on CCl(4)-induced hepatocytes damage in vitro, and the structure-activity relationships were also discussed.
Wang
Hao
H
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P.R. China.
Wu
Fei-Hua
FH
Xiong
Fei
F
Wu
Jia-Jun
JJ
Zhang
Lu-Yong
LY
Ye
Wen-Cai
WC
Li
Ping
P
Zhao
Shou-Xun
SX
D000818:Animals; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D022781:Hepatocytes / Q000187:drug effects*; D039823:Iridoids / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D028083:Scrophulariaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
D039823:Iridoids; D010936:Plant Extracts