The history of von Hippel-Lindau disease.
von Hippel-Lindau (vHL) disease is a heritable multisystem cancer syndrome that is associated with a germ line mutation of the vHL tumor suppressor gene on the short arm of chromosome 3. Affected individuals are at risk of developing various benign and malignant tumors of the central nervous system, kidneys, adrenal glands, pancreas, and epididymis. The name of this disease derives from two prestigious European physicians, Eugen von Hippel and Arvid Lindau, but many others played an important part in the description of the disorder. vHL disease has an old and modern history, thanks to the advent of new radiology and molecular biology diagnostic techniques.
Molino
Daniela
D
First Division of Nephrology and PhD Program in Nephrological Sciences, Second University of Naples, Naples, Italy.
Sepe
Joseph
J
Anastasio
Pietro
P
De Santo
Natale G
NG
D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007668:Kidney / Q000473:pathology; D006623:von Hippel-Lindau Disease / Q000235:genetics / Q000266:history* / Q000473:pathology / Q000628:therapy