FT-IR Study of the influence of Tribulus terrestris on Mercury intoxicated mice, Mus musculus liver.
FT-IR spectra of liver tissue isolated from mice, Mus musculus, have been recorded in the region of 4000 - 400 cm-1 for normal, mercury treated and recovery phase. In this study, the total protein content was found to be decreased in the liver tissues after treatment with median-lethal dose of mercuric chloride. The marked fall in the level of bio-chemical constituent in the tissue due to metal exposure indicates the rapid initiation of the breakdown of the bio-chemical constituents to meet the energy demand during toxic stress. During the recovery phase, the decreased levels of bio-chemical constituents are restored to near normal level. Methanol fractions of Tribulus terrestris fruit extract was administrated on mercury intoxicated mice for 15 days. After the administration, the mercury-intoxicated animals slowly recovered from the adverse effect of mercury poisoning with the help of plant bio-formulations. The results are discussed in detail.
Jagadeesan
G
G
Toxicological Division, Department of Zoology, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.
Kavitha
A V
AV
Subashini
J
J
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D005638:Fruit; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008627:Mercuric Chloride / Q000633:toxicity*; D008630:Mercury Poisoning / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013055:Spectrophotometry, Infrared; D032444:Tribulus
D010936:Plant Extracts; D020011:Protective Agents; D008627:Mercuric Chloride