[Maternal methyl-containing dietary supplementation alters the ability to learn in adult rats in swimming Morris test].
Maternal choline diet influences the spatial learning processes. In this work, the learning ability of adult progeny of mothers who had received methyl diet enriched with choline and betain during pregnancy and lactation was studied in Morris test. The introduction of the diet to pregnant rats resulted in an increase in the time of search for invisible platform and time of swimming near the pool walls in offsprings, which meant a worsening of their learning ability. It was also found that change in platform searching strategy was not associated with an increase in anxiety of male rats. Possible involvement of maternal methyl diet in the change of expression of genes which control development of the nervous system is discussed.
Pliusnina
I Z
IZ
Os'kina
I N
IN
Shchepina
O A
OA
Prasolova
L A
LA
Trut
L N
LN
D000818:Animals; D000831:Animals, Newborn; D001622:Betaine / Q000008:administration & dosage* / Q000378:metabolism; D002794:Choline / Q000008:administration & dosage* / Q000378:metabolism; D019175:DNA Methylation; D019587:Dietary Supplements; D005260:Female; D007774:Lactation / Q000378:metabolism*; D008297:Male; D008431:Maternal-Fetal Exchange; D018782:Maze Learning; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013037:Spatial Behavior; D013550:Swimming
D001622:Betaine; D002794:Choline