title: No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children.
abstract: The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.
authors.affiliation: Bio-X Center, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Gao
authors.forename: Xiaocai
authors.initials: X
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Fangli
authors.initials: F
authors.lastname: Dang
authors.forename: Fuchang
authors.initials: F
authors.lastname: Zhang
authors.forename: Xueqing
authors.initials: X
authors.lastname: Qian
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Zeng
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Xing
authors.forename: Zijian
authors.initials: Z
authors.lastname: Zheng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Tingwei
authors.initials: T
authors.lastname: Guo
authors.forename: Hongfen
authors.initials: H
authors.lastname: Chang
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D044466:Asian People / Q000208:ethnology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D009154:Mutation; D009483:Neuropsychological Tests; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011594:Psychometrics; D011597:Psychomotor Performance / Q000502:physiology*
chemical_list: D007703:Peptidyl-Dipeptidase A