title: Febrile seizures associated with influenza A.
abstract: To clarify the clinical impact of influenza A on the development of febrile seizures (FS), consecutive FS patients brought to our hospital between October 2003 and September 2004 were prospectively surveyed. Patients infected with influenza A (influenza A patients) and those uninfected with influenza (non-influenza patients) were compared with regard to clinical characteristics of FS. Influenza infection was determined by rapid antigen test and/or serologically. Associations of influenza A with atypical findings of FS, including partial seizures, prolonged seizures, multiple seizures during the same illness, and 30-min or longer prolonged postictal impairment of consciousness (PPIC), were analyzed by multiple logistic regression. A total of 215 patients (47 influenza A and 168 non-influenza patients) were enrolled in the study. Age was significantly higher in the influenza A group (39.85+/-22.16 months vs. 27.51+/-17.14 months, P<0.001). Of 42 patients aged 48 months or older, which corresponded to the 80th percentile for age, 15 (35.7%) were influenza A patients, with a significantly higher incidence of such patients than in the subgroup of patients aged 47 months or younger (32/173, 18.5%) (P=0.015). On multiple logistic regression analysis, influenza A was independently associated with PPIC (odds ratio: 4.44, 95% confidence interval: 1.52-12.95, P=0.006), but not with other atypical findings. The positive association of influenza A with PPIC suggests that influenza may affect state of consciousness at the same time that it induces seizures with fever.
authors.affiliation: Division of Pediatrics, Hirakata City Hospital, 2-14-1 Kinyahonmachi, Hirakata, Osaka, Japan. harakatacity@tree.odn.ne.jp
authors.forename: Keita
authors.initials: K
authors.lastname: Hara
authors.forename: Takuya
authors.initials: T
authors.lastname: Tanabe
authors.forename: Tomoki
authors.initials: T
authors.lastname: Aomatsu
authors.forename: Nao
authors.initials: N
authors.lastname: Inoue
authors.forename: Hirohumi
authors.initials: H
authors.lastname: Tamaki
authors.forename: Nami
authors.initials: N
authors.lastname: Okamoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Okasora
authors.forename: Takahiro
authors.initials: T
authors.lastname: Morimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamai
mesh_terms: D017677:Age Distribution; D001831:Body Temperature / Q000502:physiology; D015984:Causality; D002675:Child, Preschool; D015897:Comorbidity; D003244:Consciousness Disorders / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology*; D005260:Female; D005334:Fever / Q000150:complications / Q000503:physiopathology; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007251:Influenza, Human / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D007564:Japan / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D012044:Regression Analysis; D003294:Seizures, Febrile / Q000453:epidemiology* / Q000503:physiopathology / Q000821:virology*; D012698:Serologic Tests