title: Phyllodes tumor of the breast: the challenge persists.
abstract: BACKGROUND
  Phyllodes tumors of the breast are uncommon, and it is difficult to predict biologic behavior based on clinicopathologic features. Despite the wealth of data on the factors to predict recurrence, little is known about the impact of treatment refinements. This study seeks to define changes in patient characteristics, histopathologic parameters, and outcome between the two periods before and after the care of patients with breast diseases was centralized to a breast specialty.
  
  
  METHODS
  The records of 182 patients with phyllodes tumors managed surgically were reviewed. Patients treated from 1985 to 1996 (n=81) were compared with those seen from 1997 to 2004 (n=101).
  
  
  RESULTS
  The analysis of the two treatment periods revealed that there was a decrease in tumor size at diagnosis, from 7.7 cm during the earlier period to 4.6 cm during the recent period (P=0.003). The patients undergoing breast-conserving surgery were significantly increased during the recent period. In contrast, pathologic features and local recurrence rates remained unchanged during the study period. Multivariate analysis revealed that positive surgical margin was the only independent predictor of recurrence, with an increased hazard of 8.0. Overall, upgrading to the next grade was observed in 16% of recurrences.
  
  
  CONCLUSIONS
  Breast-conserving surgery with clear margins is the current treatment of choice for phyllodes tumors, but this strategy does not further reduce local recurrence effectively. Optimal management continues to be a challenge.
authors.affiliation: Department of Surgery, Mackay Memorial Hospital, 92, Sec 2, Chung-Shan North Road, and Mackay Medicine, Nursing, and Management College, Taipei, 10449, Taiwan.
authors.forename: Shih-Ping
authors.initials: SP
authors.lastname: Cheng
authors.forename: Yuan-Ching
authors.initials: YC
authors.lastname: Chang
authors.forename: Tsang-Pai
authors.initials: TP
authors.lastname: Liu
authors.forename: Jie-Jen
authors.initials: JJ
authors.lastname: Lee
authors.forename: Chi-Yuan
authors.initials: CY
authors.lastname: Tzen
authors.forename: Chien-Liang
authors.initials: CL
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D003557:Phyllodes Tumor / Q000601:surgery*