title: The polymerases for V(D)J recombination.
abstract: DNA transactions of a wide variety generally require three major types of enzymatic activities: nucleases, polymerases, and ligases. V(D)J recombination is no exception. In this issue, Bertocci et al. (2006) have provided new insight by generating mice deficient in one or more of the polymerases.
authors.affiliation: USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, 90089-9176, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Lieber
mesh_terms: D000818:Animals; D004253:DNA Nucleotidylexotransferase / Q000145:classification / Q000378:metabolism; D019951:DNA Polymerase beta / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics* / Q000378:metabolism*; D007144:Immunoglobulin J-Chains / Q000235:genetics* / Q000378:metabolism*; D011995:Recombination, Genetic / Q000235:genetics*
chemical_list: D007143:Immunoglobulin Heavy Chains; D007144:Immunoglobulin J-Chains; C415367:DNA polymerase beta2; C407743:DNA polymerase mu; D004253:DNA Nucleotidylexotransferase; D019951:DNA Polymerase beta; D004259:DNA-Directed DNA Polymerase