title: Is obesity an aggravating factor in chronic venous disease? Results of a French epidemiological study in male patients.
abstract: OBJECTIVE
  In a recent epidemiological study on chronic venous disease (CVD) in French male patients, a correlation was found between obesity and disease severity. The objective of this study was to further analyze the relationship between age and/or obesity, and CVD severity as assessed by the CEAP C-class.
  
  
  METHODS
  Each physician taking part in this cross-sectional study included the first 3 adult male patients consulting for the first time and presenting at least one sign and one symptom of CVD. Patients' socio-demographic and clinical data were collected, and findings for obese (body mass index BMI: >30 kg/m(2)), overweight (25 <BMI =or<30 kg/m(2)), and non-obese patients (BMI =or<25 kg/m(2)) compared by univariate and multivariate analyses.
  
  
  RESULTS
  A total of 192 physicians included 494 male adult patients (49.3+/-13.7 years). Among these 494 patients, 37 (7.5%) were obese, 196 (39.7%) overweight, and 256 (51.8%) non-obese. While univariate analyses pointed to more severe CVD in obese patients, multivariate analyses failed to disclose any BMI effect on CVD severity (polytomic logistic regression: P=0.1826). The differences observed between obese, overweight, and non-obese patients were age-linked (P<0.0001): obese patients were older (55.3+/-14 years) than the other patients, and CVD was more severe with age (16.9%, 26.7%, 26.6%, and 39.6% of patients aged 18-40, 41-50, 51-60, and >60 years experienced trophic disorders, i.e., CEAP classes C4, C5, and C6).
  
  
  CONCLUSIONS
  This study does not show any relationship between the CEAP C-class and obesity in male patients. Obesity was thus probably not an aggravating factor in CVD but a simple reflection of ageing.
authors.affiliation: Unit of Cardiovascular Pathology, Begin Hospital, Saint Mandé, France. snipe@easynet.fr
authors.forename: J P
authors.initials: JP
authors.lastname: Benigni
authors.forename: M
authors.initials: M
authors.lastname: Cazaubon
authors.forename: A
authors.initials: A
authors.lastname: Tourneroche
authors.forename: I
authors.initials: I
authors.lastname: Achhammer
authors.forename: M
authors.initials: M
authors.lastname: Mathieu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D016022:Case-Control Studies; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D012720:Severity of Illness Index; D014652:Vascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D014680:Veins / Q000473:pathology; D014689:Venous Insufficiency / Q000209:etiology