Highly enantioselective synthesis of beta-amino alcohols.
[reaction: see text] N,N-Dialkyl-beta-amino alcohols derived from alpha-amino acids can be rearranged enantiospecifically by using TFAA/Et3N/NaOH to give 1,2-amino alcohols with enantiomeric excess up to 99%.
Métro
Thomas-Xavier
TX
Laboratoire de Chimie Organique, associé au CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Appenzeller
Jérôme
J
Pardo
Domingo Gomez
DG
Cossy
Janine
J
D000596:Amino Acids / Q000737:chemistry*; D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D013237:Stereoisomerism
D000596:Amino Acids; D000605:Amino Alcohols