Atypical pemphigus: discordance between clinicopathological findings and the antigenic profile in four cases.
BACKGROUND
The diagnosis of pemphigus vulgaris and pemphigus foliaceus is usually based on clinical, histological, and immunofluorescence (IF) findings. In recent years, the antigenic profile of both diseases has been further defined by immunobiochemical techniques (ELISA, immunoblot, and immunoprecipitation).


METHODS
A retrospective study of 40 pemphigus patients was performed to determine the clinical, histological, and antigenic profile in patients with pemphigus followed at our Department. Charts review, clinical data, histological and IF findings, and antigenic analysis by ELISA were performed in all patients.


RESULTS
In most patients, there was a perfect correlation between the clinical and histological findings and their antigenic profile. In four patients (10%), clinicopathological features and antigenic findings were discordant.


CONCLUSIONS
The antigenic profiles in pemphigus do not always correlate with the clinical diagnosis. Therefore, clinical and histological features should be considered as the mainstay for the diagnosis of pemphigus.
Herrero-Gonzalez
Josep E
JE
Department of Dermatology, Hospital Clinic & Barcelona University School of Medicine, Barcelona, Spain.
Mascaró
José M
JM
Iranzo
Pilar
P
Herrero
Carmen
C
D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D051183:Desmoglein 1 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D004817:Epidermis / Q000276:immunology / Q000473:pathology*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000276:immunology / Q000473:pathology*; D012189:Retrospective Studies
D001323:Autoantibodies; D001324:Autoantigens; C495297:DSG1 protein, human; D051183:Desmoglein 1