title: [Somatic mutagenesis at T-cell receptor locus in inhabitants of radiation polluted regions as a result of the Chernobyl disaster].
abstract: In the period of 2001-2004, frequency of cells bearing mutations at T-cell receptor (TCR) locus was assessed in 553 inhabitants of radiation polluted regions of the Russian Federation and 154 unexposed control persons. The inhabitants were divided into three groups according to age at the moment of the Chernobyl disaster and 137Cs pollution density: 1) in utero, 37-555 kBq/m2; 2) 0-14 years old, 20-555 kBq/m2; 3) 18 and more years old, highest 137Cs density (185 more than 555 kBq/m2). The most intense changes of the TCR-mutant cell frequency were observed in the group of persons exposed to ionizing radiation in utero. The mean frequency of the mutant cells was higher in the first group than in age-matched control group by about 1.5-fold: 4.0 x 10(-4) vs 2.7 x 10(-4) accordingly (p < 0.0001). Elevation in the mean TCR-mutant cell frequency was less expressed in group of inhabitants aged 0-14 years at the moment of irradiation start: 1.3-fold increase in comparison to age-matched control (3.8 x 10(-4) vs 2.9 x 10(-4), p = 0.0002). It was not found significant differences in mutant cell frequencies between control group and adults consisting in the third group (18 and more years old at the moment of the Chernobyl accident). The changes of the TCR-mutant cell frequency in persons exposed in pre- and postnatal periods differ not only quantitatively, but qualitatively. In the fist case all persons react to irradiation by increasing number of the TCR-mutant cells in some degree. In the second case - only a part of population. Proportion of reacting persons depends on age at the start of irradiation and, perhaps, on dose absorbed. The TCR-mutant frequency was significantly higher in persons with benign tumors of different localizations and nodules in thyroid gland than in persons without this pathology.
authors.forename: I A
authors.initials: IA
authors.lastname: Zamulaeva
authors.forename: S G
authors.initials: SG
authors.lastname: Smirnova
authors.forename: N V
authors.initials: NV
authors.lastname: Orlova
authors.forename: O A
authors.initials: OA
authors.lastname: Vereshchagina
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Chekin
authors.forename: I A
authors.initials: IA
authors.lastname: Smirnova
authors.forename: L I
authors.initials: LI
authors.lastname: Krikunova
authors.forename: V S
authors.initials: VS
authors.lastname: Parshin
authors.forename: V K
authors.initials: VK
authors.lastname: Ivanov
authors.forename: A S
authors.initials: AS
authors.lastname: Saenko
mesh_terms: D047852:Chernobyl Nuclear Accident; D020732:Cytogenetic Analysis; D004781:Environmental Exposure; D004787:Environmental Pollution; D005260:Female; D019672:Genes, T-Cell Receptor; D006801:Humans; D008297:Male; D016296:Mutagenesis; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D011848:Radioactive Pollutants / Q000633:toxicity*; D012426:Russia
chemical_list: D011848:Radioactive Pollutants