A concise total synthesis of salinosporamide A.
A concise and straightforward 14-step total synthesis of (+/-)-salinosporamide A, based on a diastereoselective acid-catalysed intramolecular cyclisation of to the pyrrolidinone , and a regioselective reduction of the malonate derivative 8b to the aldehyde 9, is described.
Mulholland
Nicholas P
NP
School of Chemistry, University of Nottingham, England, UK. GP@nottingham.ac.uk
Pattenden
Gerald
G
Walters
Iain A S
IA
D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis*; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D061988:Proteasome Inhibitors; D011758:Pyrroles / Q000138:chemical synthesis*
D007783:Lactones; D011480:Protease Inhibitors; D061988:Proteasome Inhibitors; D011758:Pyrroles; C475865:marizomib