The polymerases for V(D)J recombination.
DNA transactions of a wide variety generally require three major types of enzymatic activities: nucleases, polymerases, and ligases. V(D)J recombination is no exception. In this issue, Bertocci et al. (2006) have provided new insight by generating mice deficient in one or more of the polymerases.
Lieber
Michael R
MR
USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, 90089-9176, USA.
D000818:Animals; D004253:DNA Nucleotidylexotransferase / Q000145:classification / Q000378:metabolism; D019951:DNA Polymerase beta / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics* / Q000378:metabolism*; D007144:Immunoglobulin J-Chains / Q000235:genetics* / Q000378:metabolism*; D011995:Recombination, Genetic / Q000235:genetics*
D007143:Immunoglobulin Heavy Chains; D007144:Immunoglobulin J-Chains; C415367:DNA polymerase beta2; C407743:DNA polymerase mu; D004253:DNA Nucleotidylexotransferase; D019951:DNA Polymerase beta; D004259:DNA-Directed DNA Polymerase