High pass digital filtering applied to quantitative UV spectrometry.
High pass digital filtering is a novel method of data treatment for quantitative UV spectrometry in the presence of broad interfering bands. The test and standard spectra are digitally filtered using the binomial filter to remove low frequency components and a least squares fit of the standard to the test is then carried out. This paper reports a preliminary evaluation of the method, including a theoretical comparison with derivative spectrometry and the successful application to a typical problem in pharmaceutical analysis, the assay of the decongestant pseudoephedrine hydrochloride in the presence of the antihistamine triprolidine hydrochloride. The procedure should also be suitable for enhancing the specificity of other spectroscopic techniques.
Jones
R
R
Analytical Development Laboratories, The Wellcome Foundation Limited, Temple Hill, Dartford, Kent DA1 5AH, UK.
Leadley
B S
BS