title: [Analysis of HLA-B locus gene polymorphism in Sichuan Yi ethnic group and Xinjiang Uygur ethnic group].
abstract: The polymorphism of HLA-B alleles in Sichuan Yi and Xinjiang Uygur population was investigated using the PCR-SSP method. Twenty one alleles were detected in HLA-B loci in 106 Sichuan unrelated Yi healthy subjects. Of them, B*40, B*15 and B*51 were the most common alleles with an allele frequency of 0.1981, 0.1368, 0.1274, respectively; while B*47, B*44, B*18, B*57 and B*78 were the rare alleles with an allele frequency of 0.0189, 0.0142, 0.0094, 0.0047 and 0.0047, respectively. The distribution of HLA-B allele frequencies in Sichuan Yis was between Southern Han and Northern Han. In 110 Xinjiang unrelated healthy Uygur subjects, 27 alleles were detected in HLA-B loci. Of them, B*35 and B*51 were the most common alleles with an allele frequency of 0.1136 and 0.1136, respectively; while B*41, B*56 and B*78 were the rare alleles with a frequency of 0.0045, 0.0045 and 0.0091, respectively. Frequencies of "Caucasoid origin" HLA alleles such as B*08, B*35 and B*50 in Xinjiang Uygurs were higher than other ethnic groups in China. The result of chi2 tests showed that the distributions of HLA-B alleles in Yi and Uygur ethnic groups were in Hardy-Weinberg equilibrium. Heterozygosity (H), discrimination power (DP) and probability of paternity exclusion (EP) of HLA-B locus from Sichuan Yi ethnic group were computed to be 0.8977, 0.9661 and 0.8009; and those from Xinjiang Uygur ethnic group were 0.9372, 0.9857 and 0.8732. The data obtained in this study on the distributions of HLA-B alleles in the Sichuan Yi and Xinjiang Uygur population provide important group genetics information for forensic and paternity tests to estimate the frequency of a DNA profile in these two populations, and can be used in transplant matching, anthropological and disease association studies.
authors.affiliation: Division of Research on Virology and Immunology, National Center for STD/AIDS Control and Prevention, Beijing 100050, China. myxu@stu.edu.cn
authors.forename: Ming-Yan
authors.initials: MY
authors.lastname: Xu
authors.forename: Kun-Xue
authors.initials: KX
authors.lastname: Hong
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Deng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Peng
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Ruan
authors.forename: Guan-Ming
authors.initials: GM
authors.lastname: Qin
authors.forename: Yuan-Zhi
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Xiao-Hu
authors.initials: XH
authors.lastname: Xu
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shao
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic
chemical_list: D015235:HLA-B Antigens