PRINS combined with peptide nucleic acid labeling.
Both primed in situ labeling (PRINS) and peptide nucleic acid (PNA) technologies have emerged as research techniques, but they have quickly evolved to applications in biological diagnosis assays. The two procedures present several features (specificity, discriminating ability, rapidity) that make them very attractive for cytogenetic purposes. The combined use of PRINS and PNA for in situ chromosomal detection on a same cell preparation is described in this chapter.
Pellestor
Franck
F
Institute of Human Genetics, CNRS UPR 1142, Montpellier, France.
Paulasova
Petra
P
D002877:Chromosomes, Human / Q000235:genetics; D006801:Humans; D020135:Peptide Nucleic Acids / Q000032:analysis* / Q000737:chemistry*; D020401:Primed In Situ Labeling / Q000379:methods*
D020135:Peptide Nucleic Acids