B-1 B cells: development, selection, natural autoantibody and leukemia.
B-1 (CD5+) B cells constitute a phenotypic and functionally distinct population of B cells in mouse that show enriched expression of autoreactive B-cell antigen receptors and that produce several types of natural autoantibodies. Recently, there has been much progress in this field of research. Evidence has appeared for the existence of distinctive B-cell precursors that preferentially generate B-1 B cells, and the crucial requirement for strong B-cell antigen receptor signaling in the maturation of B-1 B cells has been established. Other work focuses on a phenotypically similar population that lacks CD5, termed 'B-1b', which shows similarities and differences from most CD5+ B cells in both development and function. The relationship of normal B-1 cells with B-cell lymphomas and leukemias continues to be a subject of interest and debate.
Hardy
Richard R
RR
Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. rr_hardy@fccc.edu
D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000502:physiology*; D018956:CD5 Antigens; D016130:Immunophenotyping; D007938:Leukemia / Q000097:blood / Q000276:immunology*; D038041:Lymphopoiesis; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D015398:Signal Transduction
D001323:Autoantibodies; D001324:Autoantigens; D018956:CD5 Antigens; D011947:Receptors, Antigen, B-Cell