title: Temporomandibular joint cytokine profiles in the horse.
abstract: It has been suggested that dental abnormalities lead to temporomandibular joint inflammation and pain that may be mitigated by regular dental care. There is considerable literature on the pathophysiology of equine joint disease including studies on cytokine profiles in diseased appendicular joints. This study examined the effects of age and dental malocclusions summarized as a dental pathology score on equine temporomandibular joint cytokine (IL-1, IL-6, IL-8, TNF alpha and TGF-beta1, -beta2, -beta3) concentrations. TGF-beta3 was not detected in any joint sample. IL-1, IL-6 and TNF alpha were not influenced by age. Foals had significantly lower concentrations of lL-8 and TGF-beta1, and higher levels of TGF-beta2 compared with older horses. Age did not effect cytokine concentration in older horses although there was a trend towards increasing 1L-8 with age. The dental pathology score increased with age in mature horses, however there was no effect of dental pathology score on cytokine concentration. There was no effect of incisor eruption, and presence or number of periodontal lesions on temporomandibular joint cytokine concentration. Our findings indicate that age but not dental pathology affected temporomandibular joint proinflammatory cytokine concentration in this population of horses.
authors.affiliation: Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada. carmalt_vet@hotmail.com
authors.forename: James L
authors.initials: JL
authors.lastname: Carmalt
authors.forename: John R
authors.initials: JR
authors.lastname: Gordon
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Allen
mesh_terms: D000375:Aging; D000818:Animals; D016207:Cytokines / Q000276:immunology*; D003774:Dental Plaque Index; D006734:Horse Diseases / Q000276:immunology* / Q000473:pathology; D006736:Horses / Q000276:immunology; D010510:Periodontal Diseases / Q000150:complications / Q000276:immunology / Q000662:veterinary*; D013582:Synovial Fluid / Q000276:immunology; D013704:Temporomandibular Joint / Q000276:immunology*; D013705:Temporomandibular Joint Disorders / Q000150:complications / Q000276:immunology / Q000662:veterinary*
chemical_list: D016207:Cytokines