title: Can specific vessel-based papulopustular lesions of Behçet's disease be differentiated from nonspecific follicular-based lesions clinically?
abstract: BACKGROUND
  Although papulopustular lesions are one of the diagnostic criteria for Behçet's disease, controversy exists as to the nature of these lesions. Specific vessel-based papulopustular lesions as well as nonspecific follicular lesions may be seen in patients with Behçet's disease. Some authors suggest that papulopustular lesions should be considered a positive criterion only if they exhibit a vessel-based neutrophilic reaction.
  
  
  OBJECTIVE
  [corrected] To determine whether specific vessel-based papulopustular lesions can be differentiated clinically from nonspecific follicular lesions in patients with Behçet's disease.
  
  
  METHODS
  Twenty-three papulopustular lesions in 20 patients with Behçet's disease were initially examined clinically by two dermatologists blind to each other's diagnosis. Biopsies taken from these lesions were examined by a pathologist unaware of the patient data.
  
  
  RESULTS
  Leukocytoclastic vasculitis or perivascular infiltration was observed in 10 lesions, perifollicular and perivascular infiltration was noted in nine lesions, and perifollicular inflammation was seen in four biopsy specimens. Most of the lesions interpreted clinically as specific papulopustular lesions of Behçet's disease had predominantly perivascular infiltration or leukocytoclastic vasculitis; however, three papulopustular lesions evaluated by both observers as specific papulopustular lesions had only perifollicular inflammation, and one lesion diagnosed clinically as a nonspecific follicular eruption revealed perivascular neutrophilic reaction. Interobserver variance was noted in three papulopustular lesions.
  
  
  CONCLUSIONS
  Clinical examination may not be sufficient to predict the dermatopathologic pattern in all lesions. Papulopustular lesions with no specific clinical and histopathologic features may create problems in the diagnosis of Behçet's disease.
authors.affiliation: Department of Dermatology and Pathology, Ankara University School of Medicine, Ankara, Turkey. boyvat@medicine.ankara.edu.tr
authors.forename: Ayşe
authors.initials: A
authors.lastname: Boyvat
authors.forename: Aylin Okçu
authors.initials: AO
authors.lastname: Heper
authors.forename: Pelin
authors.initials: P
authors.lastname: Koçyiğit
authors.forename: Selim
authors.initials: S
authors.lastname: Erekul
authors.forename: Erbak
authors.initials: E
authors.lastname: Gürgey
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000473:pathology*; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D018859:Hair Follicle; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012867:Skin / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000473:pathology*