Reversed-phase ion-pair liquid chromatography of some quaternary ammonium drugs.
The resolving power of a reversed-phase liquid chromatographic method that makes use of a mobile phase system with two counter-ions of opposite charge (N,N-dimethyloctylamine and sodium octanesulphonate) for the separation of quaternary ammonium drugs, is compared with that obtained using more traditional ion-pairing systems. Efficient, selective and well-resolved separations could only be obtained by the combined effects of the eluent modifiers.
De Schutter
J A
JA
Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmaceutical Sciences, State University of Ghent, Harelbekestraat 72, B-9000-Ghent, Belgium.
De Moerloose
P
P