title: Early and severe hyperparathyroidism associated with hypercalcemia after renal transplant treated with cinacalcet.
abstract: Bone disease is a common clinical problem following renal transplantation. In renal transplant recipients, multiple underlying factors determine the extent of bone loss and the subsequent risk of fractures. In addition to the well-recognized risk to bone disease posed by steroids, calcineurin inhibitors and pre-existing bone disease, persistent hyperparathyroidism (HPT) contributes to post-transplant bone loss. HPT is usually treated with vitamin D supplements combined with calcium. Patients whose HPT is associated with hypercalcemia pose a difficult therapeutic dilemma which often requires parathyroidectomy. Cinacalcet, a calcium mimetic agent, offers a unique pharmacologic approach to the treatment of patients with post-transplant hypercalcemia and HPT. In this paper, we describe the clinical course and biochemical changes in 10 renal transplant recipients with hypercalcemia and severe HPT early after renal transplantation treated with cinacalcet. Cinacalcet therapy corrected hypercalcemia and decreased parathyroid hormone (PTH) levels in all cases. A transient rise in the level of alkaline phosphatase was noted following initiation of cinacalcet therapy. In this patient population, correction of HPT was not permanent as discontinuing cinacalcet therapy led to a rapid rise in PTH level.
authors.affiliation: Department of Medicine, SUNY University at Buffalo, NY, USA.
authors.forename: N
authors.initials: N
authors.lastname: Leca
authors.forename: M
authors.initials: M
authors.lastname: Laftavi
authors.forename: A
authors.initials: A
authors.lastname: Gundroo
authors.forename: R
authors.initials: R
authors.lastname: Kohli
authors.forename: I
authors.initials: I
authors.lastname: Min
authors.forename: J
authors.initials: J
authors.lastname: Karam
authors.forename: N
authors.initials: N
authors.lastname: Sridhar
authors.forename: G
authors.initials: G
authors.lastname: Blessios
authors.forename: R
authors.initials: R
authors.lastname: Venuto
authors.forename: O
authors.initials: O
authors.lastname: Pankewycz
mesh_terms: D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D000069449:Cinacalcet; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006961:Hyperparathyroidism / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D016030:Kidney Transplantation / Q000009:adverse effects*; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D010281:Parathyroid Hormone / Q000097:blood; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D009281:Naphthalenes; D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D002118:Calcium; D000069449:Cinacalcet