Mycobacterium bovis BCG mycobacteria--new application.
The polarized response of T helper-2 (Th2) lymphocytes to an allergen is considered to be the main cause of the pathogenesis of asthma. In this study, we asked a question whether M. bovis BCG mycobacteria which are known for the preferential stimulation of T helper-1 (Th1) immunity, diminish the effector functions of Th2 cells from allergic patients upon stimulation with a common house dust mite Der p-1 allergen. Our results allow a positive answer to this question. We demonstrate that BCG modulates the dendritic cell-dependent allergen presentation process and switches naive T lymphocytes towards an anti-allergic Th1 profile.
Kowalewicz-Kulbat
Magdalena
M
Department of Immunology and Infectious Biology, Institute for Microbiology and Immunology, University of Lódź, Banacha 12/16, 90-237 Lódź, Poland,
Pestel
Joël
J
Biet
Franck
F
Locht
Camille
C
Tonnel
André-Bernard
AB
Druszczyńska
Magdalena
M
Rudnicka
Wiesława
W
D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D060829:Arthropod Proteins; D001500:BCG Vaccine / Q000276:immunology*; D018920:Coculture Techniques / Q000379:methods; D003546:Cysteine Endopeptidases; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology; D015848:Interleukin-5 / Q000276:immunology; D039981:Pyroglyphidae / Q000276:immunology*; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism
D039741:Antigens, Dermatophagoides; D060829:Arthropod Proteins; D001500:BCG Vaccine; C508598:IL4 protein, human; C508599:IL5 protein, human; D015848:Interleukin-5; D015847:Interleukin-4; D007371:Interferon-gamma; D003546:Cysteine Endopeptidases; C451162:Dermatophagoides pteronyssinus antigen p 1