Handedness effects on interhemispheric transfer time: a TMS study.
The crossed-uncrossed difference (CUD) estimates the interhemispheric transfer time (ITT) through the corpus callosum. Previous research has shown that transcranial magnetic stimulation (TMS) to the occipital cortex determines an increased CUD during cognitive tasks. The aim of the present study was to investigate whether TMS stimulation applied at a motor stage can interfere with the ITT, comparing the performance of left- and right-handed people. Results showed a significant TMS effect, i.e. increasing reaction times were reported when stimulation was delivered on the left primary motor area. Effects were more evident when information was primarily perceived through the dominant hemisphere. Both left and right stimulations increased CUD times in right-handed subjects; however, left-handed subjects showed significant effects associated with left stimulation only. Furthermore, in both groups, TMS produced larger effects in the crossed than in the uncrossed condition. TMS stimulation increased reaction times, thus supporting the idea that the interhemispheric transfer of visuo-motor information occurs at a motor processing stage. The dominant hemisphere seems to play a major role within this process: our data indicates that left- and right-handed people have different ITT latencies associated with the transfer of information to the contralateral hemisphere.
Basso
Demis
D
Laboratory of Clinical Biochemistry and Molecular Biology, University of Pisa, Italy. demis.basso@unipv.it
Vecchi
Tomaso
T
Kabiri
Lilach Akiva
LA
Baschenis
Ilaria
I
Boggiani
Elisa
E
Bisiacchi
Patrizia S
PS
D000328:Adult; D001921:Brain / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation