title: [Expression of c-fos protein after muscle contusion in experimental rats].
abstract: OBJECTIVE
  To study the relationship between the expression of c-Fos protooncogene and skeleton muscle contusion of rats, and to search for a sensitive marker of timing for skeleton muscle contusion.
  
  
  METHODS
  Fifty Sprague-Dawley rats were randomly distributed into control group and experimental groups. The expression of c-fos was microscopically observed by immunohistochemical method.
  
  
  RESULTS
  With the time prolonged the c-fos positive intensity and area were increased. Positive expression of c-fos protein appeared at 15 min after skeleton muscle contusion, and reached to the peak at 1h after skeleton muscle contusion, then decreased gradually and returned to the normal level on 1d after skeleton muscle contusion.
  
  
  CONCLUSIONS
  The detection of the expression of c-fos protein could be a sensitive marker for timing skeleton muscle contusion.
authors.affiliation: Forensic Pathology Department, College of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. yanht678@163.com
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Yan
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Qi-Yi
authors.initials: QY
authors.lastname: Peng
authors.forename: Ye
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Xing
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Liao
authors.forename: Min
authors.initials: M
authors.lastname: Liu
mesh_terms: D000818:Animals; D003288:Contusions / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006614:Hindlimb / Q000293:injuries*; D007150:Immunohistochemistry; D008297:Male; D018482:Muscle, Skeletal / Q000293:injuries* / Q000378:metabolism* / Q000473:pathology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling; D013997:Time Factors
chemical_list: D016760:Proto-Oncogene Proteins c-fos