title: Prognostic factors in the treatment of generalized aggressive periodontitis: I. Clinical features and initial outcome.
abstract: OBJECTIVE
  The aims of this study were to investigate prognostic factors for initial response to non-surgical periodontal treatment for generalized aggressive periodontitis.
  
  
  METHODS
  Seventy-nine patients with generalized aggressive periodontitis were included in this prospective follow-up intervention study. Patients' clinical and demographic parameters were collected at baseline and 10 weeks following a standard course of treatment (four visits of non-surgical root surface debridement together with OHI as required). The relationship between clinical variables and treatment outcome were analysed at site-specific level by chi(2) analysis and for patient-specific variables by logistic regression.
  
  
  RESULTS
  In general, there was a good response to the treatment provided. In deep sites the mean pocket depth reduction was 2.11+/-2.01 mm. Site-specific analysis showed that the presence of plaque had a small but significant predictive effect on outcome (odds ratio 1.4). Sites on teeth with grade II/III mobility showed a significantly reduced response to treatment. Twenty-five patients were classified as "non-responders". Current smoking was strongly associated with non-responding patients (odds ratio 3.8) in a logistic regression model; plaque, baseline bleeding and initial pocket depth were not significantly associated with treatment outcomes.
  
  
  CONCLUSIONS
  Overall, the results emphasize the importance of smoking as a negative prognostic factor, and suggest that treatment outcomes may be determined by a wide range of different determinants requiring further study.
authors.affiliation: Collaborative Group in Risk Factors for Periodontal Disease, Institute of Dentistry, Queen Mary's School of Medicine, London, UK. f.j.hughes@qmul.ac.uk
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Hughes
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Syed
authors.forename: Bindhu
authors.initials: B
authors.lastname: Koshy
authors.forename: Valeria
authors.initials: V
authors.lastname: Marinho
authors.forename: Nagihan
authors.initials: N
authors.lastname: Bostanci
authors.forename: Ian J
authors.initials: IJ
authors.lastname: McKay
authors.forename: Michael A
authors.initials: MA
authors.lastname: Curtis
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Croucher
authors.forename: Wagner
authors.initials: W
authors.lastname: Marcenes
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003773:Dental Plaque / Q000628:therapy; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000628:therapy; D005884:Gingival Hemorrhage / Q000628:therapy; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009910:Oral Hygiene; D017622:Periodontal Attachment Loss / Q000628:therapy; D010514:Periodontal Pocket / Q000628:therapy; D010518:Periodontitis / Q000628:therapy*; D011379:Prognosis; D011446:Prospective Studies; D016745:Root Planing; D012907:Smoking / Q000009:adverse effects; D013357:Subgingival Curettage; D014086:Tooth Mobility / Q000628:therapy; D016896:Treatment Outcome