title: Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety.
abstract: A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangothri 574199, India. karthims02@rediffmail.com
authors.forename: Mari Sithambaram
authors.initials: MS
authors.lastname: Karthikeyan
authors.forename: Dasappa Jagadeesh
authors.initials: DJ
authors.lastname: Prasad
authors.forename: Boja
authors.initials: B
authors.lastname: Poojary
authors.forename: K
authors.initials: K
authors.lastname: Subrahmanya Bhat
authors.forename: Bantwal Shivarama
authors.initials: BS
authors.lastname: Holla
authors.forename: Nalilu Suchetha
authors.initials: NS
authors.lastname: Kumari
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D002713:Chlorine / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005461:Fluorine / Q000737:chemistry*; D006095:Gram-Positive Cocci / Q000187:drug effects; D008352:Mannich Bases / Q000138:chemical synthesis / Q000737:chemistry; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D008352:Mannich Bases; D012545:Schiff Bases; D005461:Fluorine; D002713:Chlorine