title: Direct quantitation of antiseptic quaternary ammonium compounds by fast atom bombardment mass spectrometry.
abstract: The medicinally important quaternary ammonium salts benzyldimethyltetradecylammonium chloride (BDTA), cetylpyridinium chloride and benzethonium chloride, all afford, under fast atom bombardment (FAB) mass spectrometric conditions, abundant and persistent [M-Cl]+ species usefully amenable to quantitative analysis with the aid of thioglycerol as a liquid FAB matrix. The use of BDTA as an internal standard allowed a direct, precise and accurate determination of cetylpyridinium and benzethonium chlorides, either as pure samples or in dosage forms, in the concentration range 0.05-2 mg/ml.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via G. Capponi 9, 50121 Firenze, Italy.
authors.forename: M B
authors.initials: MB
authors.lastname: Alberti
authors.forename: S
authors.initials: S
authors.lastname: Pinzauti
authors.forename: G
authors.initials: G
authors.lastname: Moneti
authors.forename: G
authors.initials: G
authors.lastname: Agati
authors.forename: V
authors.initials: V
authors.lastname: Giannellini
authors.forename: S A
authors.initials: SA
authors.lastname: Coran
authors.forename: F F
authors.initials: FF
authors.lastname: Vincieri