Differential proteomic alterations between localised and metastatic prostate cancer.
Molecular alterations in the prostate cancer proteome mediate the functional and phenotypic transformation from clinically localised to metastatic cancer, a transition that drives patient's mortality and challenges therapeutic intervention. A first approximation of differential proteomic alterations stratified by disease stage has yielded repertoires of potential diagnostic and prognostic markers, multiplex signatures of predictive value, and yield fundamental insight into molecular commonalities in cancer progression. Deciphering these causative proteomic alterations from the molecular noise will continue to mature our understanding of tumour biology and drive new computational and integrative approaches to model a system's view that accommodates the heterogeneity of prostate cancer progression.
Taylor
B S
BS
Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA.
Varambally
S
S
Chinnaiyan
A M
AM
D014408:Biomarkers, Tumor / Q000032:analysis; D018450:Disease Progression; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000175:diagnosis; D009363:Neoplasm Proteins / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins