title: [Mechanism of actions and clinical applications of proton pump inhibitors].
abstract: Proton pump inhibitors (PPIs) are widely used in clinical practice from early 1990s for the treatment of acid- related diseases. PPIs are superior to histamine2-receptor antagonists or anticholinergic agents. These drugs have proven to be effective, safe and well-tolerated during the past two decades. This brief review presents the pharmacodynamics and pharmacokinetics of PPIs and presents clinical applications of the drugs in acid-related diseases.
authors.affiliation: Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea. seolsymd@hanmail.net
authors.forename: Sang Yong
authors.initials: SY
authors.lastname: Seol
mesh_terms: D005744:Gastric Acid / Q000378:metabolism*; D005765:Gastrointestinal Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D054328:Proton Pump Inhibitors
chemical_list: D005765:Gastrointestinal Agents; D054328:Proton Pump Inhibitors