Comparative evaluation of oral fluorescein angiography using the confocal scanning laser ophthalmoscope and digital fundus camera with intravenous fluorescein angiography using the digital fundus camera.
BACKGROUND
To study the efficacy of oral fluorescein angiography (FA) with confocal scanning laser ophthalmoscope (CSLO).


METHODS
Ten patients each of choroidal neovascular membrane, central serous retinopathy, diabetic retinopathy and five normal subjects were evaluated with group 1 - intravenous FA using digital fundus camera (DFC); group 2 - oral FA using DFC; and group 3 - oral FA using CSLO.


RESULTS
Third-order branch vessels were identified in 85.7% eyes in group 3 versus 51.4% in group 2 (P = 0.004), image quality was comparable to intravenous FA in 77.1% in group 3 versus 48.5% in group 2 (P = 0.02) and margin delineation was better in 80% eyes in group 3 versus 35% in group 2 (P = 0.01). The foveal avascular zone was clear and intact in 54.2% eyes in group 3 versus 37.1% in group 2 (P = 0.14) and 57.1% in group 1 (P = 0.8).


CONCLUSIONS
Oral FA using CSLO is superior to oral FA using DFC and comparable to intravenous FA using DFC in terms of image quality, branch retinal vessel identification and margin delineation.
Azad
Raj Vardhan
RV
Vitreo-Retina Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. rajvardhanazad@hotmail.com
Baishya
Bipul
B
Pal
Nikhil
N
Sharma
Yog Raj
YR
Kumar
Atul
A
Vohra
Rajpal
R
D000284:Administration, Oral; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D003287:Contrast Media / Q000008:administration & dosage*; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D019793:Fluorescein / Q000008:administration & dosage*; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D007275:Injections, Intravenous; D007834:Lasers; D019721:Ophthalmoscopes; D010781:Photography / Q000379:methods; D012171:Retinal Vessels / Q000473:pathology*
D003287:Contrast Media; D019793:Fluorescein