title: Historical control clinical trial to assess the effectiveness of teflubenzuron for treating sea lice on Atlantic salmon.
abstract: A historical control clinical trial was performed to assess the effectiveness of teflubenzuron in controlling sea lice Lepeoptheirus salmonis burdens on farmed Atlantic salmon Salmo salar over time. The study site comprised 9 sea cages, all of which were treated. The teflubenzuron was administered in the feed, at a dosage of 10 mg kg(-1) biomass d(-1), over a treatment period of 7 d. At 1 wk post-treatment, sea lice chalimus and mobile stages were reduced by 92 and 74% (both p < 0.001), respectively. At 2 wk post-treatment, chalimus stages were reduced by 41% and mobile stages 61% (both p < 0.001) compared to pre-treatment levels. At 3 wk post-treatment, chalimus stages were still 36% (p < 0.001) lower than pre-treatment levels, but mobile stages had increased to above pre-treatment levels. Our results show that the effects of teflubenzuron are limited to a 3 wk duration, but that with appropriate management, farms could benefit from these reduced lice burdens for longer periods.
authors.affiliation: Department of Health Management, Atlantic Veterinary College, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3, Canada.
authors.forename: P J
authors.initials: PJ
authors.lastname: Campbell
authors.forename: K L
authors.initials: KL
authors.lastname: Hammell
authors.forename: I R
authors.initials: IR
authors.lastname: Dohoo
authors.forename: G
authors.initials: G
authors.lastname: Ritchie
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000494:pharmacology*; D033342:Copepoda / Q000187:drug effects*; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D004777:Environment; D005393:Fish Diseases / Q000188:drug therapy* / Q000469:parasitology; D005398:Fisheries / Q000379:methods; D008018:Life Cycle Stages / Q000187:drug effects; D020317:Salmo salar / Q000469:parasitology*; D013997:Time Factors
chemical_list: D001549:Benzamides; C052595:teflubenzuron