title: Deregulated NF-kappaB activity in haematological malignancies.
abstract: The NF-kappaB family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappaB activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappaB deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor.
authors.affiliation: Laboratory of Medical Chemistry, Center for Cellular and Molecular Therapy, Center for Biomedical Integrative Genoproteomics, University of Liege, Tour de Pathologie, +3 B23, CHU Sart-Tilman, 4000 Liège, Belgium.
authors.forename: Aurore
authors.initials: A
authors.lastname: Keutgens
authors.forename: Isabelle
authors.initials: I
authors.lastname: Robert
authors.forename: Patrick
authors.initials: P
authors.lastname: Viatour
authors.forename: Alain
authors.initials: A
authors.lastname: Chariot
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D049109:Cell Proliferation; D005786:Gene Expression Regulation / Q000502:physiology; D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism* / Q000502:physiology
chemical_list: D016328:NF-kappa B