title: Detection and classification of the mucosal and vascular patterns (mucosal morphology) in Barrett's esophagus by using narrow band imaging.
abstract: BACKGROUND
  The detection of the mucosal morphology (ie, mucosal and vascular patterns) in Barrett's esophagus (BE) by magnifying (chromo)endoscopy may improve the distinction of high-grade intraepithelial neoplasia (HGIN) from nondysplastic specialized intestinal metaplasia (SIM). Narrow band imaging (NBI) is a new technique that uses optical filters to enhance the mucosal contrast without the need for chromoendoscopy.
  
  
  OBJECTIVE
  To use NBI for the characterization and the classification of the mucosal morphology in nondysplastic BE and in BE with HGIN.
  
  
  METHODS
  Descriptive study.
  
  
  METHODS
  Single-center study in a tertiary referral center for the diagnosis and treatment of patients with BE.
  
  
  METHODS
  We used NBI with magnifying endoscopy to image and biopsy randomly selected areas in 63 patients with BE. A systematic image and a biopsy specimen evaluation process was followed, including unblinded assessment of an exploratory set of images and biopsy specimens, and blinded evaluation of learning and validation sets.
  
  
  METHODS
  The relationship between the mucosal morphology and the presence of SIM and HGIN.
  
  
  RESULTS
  SIM was characterized by either villous/gyrus-forming patterns (80%), which were mostly regular and had regular vascular patterns, or a flat mucosa with regular normal-appearing long branching vessels (20%). HGIN was characterized by 3 abnormalities: irregular/disrupted mucosal patterns, irregular vascular patterns, and abnormal blood vessels. All areas with HGIN had at least 1 abnormality, and 85% had 2 or more abnormalities. The frequency of abnormalities showed a significant rise with increasing grades of dysplasia. The magnified NBI images had a sensitivity of 94%, a specificity of 76%, a positive predictive value of 64%, and a negative predictive value of 98% for HGIN.
  
  
  CONCLUSIONS
  No data on observer agreement.
  
  
  CONCLUSIONS
  NBI with magnification reveals the mucosal morphology characteristics of nondysplastic BE and HGIN, without the need for staining and has a relatively high diagnostic value for HGIN when used for targeted detailed examination of areas of interest.
authors.affiliation: Department of Gastroenterology, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Kara
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ennahachi
authors.forename: Paul
authors.initials: P
authors.lastname: Fockens
authors.forename: Fiebo J W
authors.initials: FJ
authors.lastname: ten Kate
authors.forename: Jacques J G H M
authors.initials: JJ
authors.lastname: Bergman
mesh_terms: D000368:Aged; D001471:Barrett Esophagus / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004947:Esophagus / Q000098:blood supply / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D018570:Risk Assessment; D012680:Sensitivity and Specificity