title: [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].
abstract: Behavioral and psychological symptoms of dementia (BPSD) includes anxiety, depression, hallucination, delusion, aggression, irritability, agitation and wandering. BPSD often causes a deterioration of activity of daily living (ADL) and worsens caregiver burden. Trazodone, an atypical antidepressant, is used for the treatment of BPSD, but the effectiveness is controversial. In this study, we retrospectively analyzed the medical records of the 13 AD patients who were rated as having the aggression and negativism in caregiving situation and were treated by trazodone. The BPSD of the per-treatment stage of the patients was assessed with Neoropsychiatric Inventory(NPI). Improvement of BPSD after trazodone was observed in 9 patients, and the aggression and negativism in caregiving situations were improved in 6 patient. Trazodone may be effect for the treatment of a certain type of BPSD such as aggression and negativism in caregiving situations. Prospective studies of this issue are recommended in AD patient.
authors.affiliation: Department of Speech Therapy, School of Health Sciences, Niigata University of Health and Welfare, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kudo
authors.forename: Toru
authors.initials: T
authors.lastname: Imamura
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000374:Aggression / Q000523:psychology*; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001519:Behavior; D017028:Caregivers; D003704:Dementia / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009341:Negativism; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D014196:Trazodone / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D014196:Trazodone