title: Primary hypothyroidism presenting as ovarian tumor and precocious puberty in a prepubertal girl.
abstract: We report a case of a prepubertal girl with juvenile primary hypothyroidism presenting as ovarian cysts and precocious puberty. The 7-year-old female was referred to our clinic because of a pelvic/abdominal mass and vaginal bleeding. Besides these findings, on physical examination we noticed the thyroid gland globally increased and the presence of secondary sexual characteristics. Based upon the clinical profile and investigations, the patient was diagnosed with juvenile primary hypothyroidism due to autoimmune thyroiditis. The cysts and precocious puberty resolved spontaneously after the simple replacement of thyroid hormone. It is important to bear in mind hypothyroidism in cases of girls presenting ovarian cysts and precocious puberty in order to avoid unnecessary surgery on the ovaries.
authors.affiliation: Department of Obstetrics and Gynecology, Santa Casa São Paulo-Faculty of Medical Science, São Paulo, Brazil. abcampaner@terra.com.br
authors.forename: Adriana B
authors.initials: AB
authors.lastname: Campaner
authors.forename: Alessandro
authors.initials: A
authors.lastname: Scapinelli
authors.forename: Ruy O
authors.initials: RO
authors.lastname: Machado
authors.forename: Roberto E
authors.initials: RE
authors.lastname: Dos Santos
authors.forename: Geni W
authors.initials: GW
authors.lastname: Beznos
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Aoki
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D010048:Ovarian Cysts / Q000000981:diagnostic imaging / Q000209:etiology*; D011629:Puberty, Precocious / Q000209:etiology*; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013967:Thyroiditis, Autoimmune / Q000150:complications; D013974:Thyroxine / Q000627:therapeutic use; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000175:diagnosis
chemical_list: D013974:Thyroxine