Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat.
The effects of extracts of Crocus sativus L. (CSE), on memory were investigated in the rat by using the object recognition and the step-through passive avoidance task. In the first study, post-training administration of CSE (30 and 60 g/kg) successfully counteracted extinction of recognition memory in the normal rat, suggesting that CSE modulates storage and/or retrieval of information. In a subsequent study, pre-training treatment with CSE (30 and 60 mg/kg) significantly antagonized the scopolamine (0.75 mg/kg)-induced performance deficits in the step-through passive avoidance test. These results support and extend prior findings about the implication of CSE in learning and memory mechanisms.
Pitsikas
Nikolaos
N
Department of Pharmacology, School of Medicine, University of Thessaly, 22 Papakiriazi Str., 412-22 Larissa, Greece. npitsikas@med.uth.gr
Sakellaridis
Nikolaos
N
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D027622:Crocus; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior; D005108:Extinction, Psychological / Q000187:drug effects*; D035264:Flowers; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D021641:Recognition, Psychology / Q000187:drug effects*
D018697:Nootropic Agents; D010936:Plant Extracts