Molecular aspects of fever and hyperthermia.
A rise in core temperature during fever usually results from change in the thermocontroller characteristics, resulting in an elevation of the set point of body temperature. Time course and extent of natural fevers are variable, but an upper limit (41 degrees C in humans), at which core temperature is maintained for some time and reduced when the set point of body temperature returns to its normal level, rarely is exceeded. Although any rise in body temperature may result from fever, those rises that are not accompanied by supportive changes in thermoeffector activities are termed hyperthermia.
Roth
Joachim
J
Department of Veterinary Physiology, Faculty of Veterinary Medicine, Justus-Liebig-University, Giessen, Germany. Joachim.Roth@vetmed.uni-giessen.de
Rummel
Christoph
C
Barth
Stephan W
SW
Gerstberger
Rüdiger
R
Hübschle
Thomas
T
D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology; D001833:Body Temperature Regulation / Q000276:immunology; D001921:Brain / Q000098:blood supply / Q000276:immunology*; D002552:Cerebral Ventricles / Q000276:immunology; D051546:Cyclooxygenase 2 / Q000502:physiology; D016207:Cytokines / Q000097:blood; D015232:Dinoprostone / Q000502:physiology; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000276:immunology; D005334:Fever / Q000276:immunology*; D006801:Humans; D007239:Infections / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D051381:Rats
D016207:Cytokines; D008070:Lipopolysaccharides; D051546:Cyclooxygenase 2; D015232:Dinoprostone