title: The efficacy and economic benefits of Supercox, a live anticoccidial vaccine in a commercial trial in broiler chickens in China.
abstract: The efficacy and economic benefits of Supercox, a live anticoccidial vaccine were examined and compared with an anticoccidial drug in a trial in broiler chickens under modern commercial conditions in China. In total, 40,660 chickens were used in the present study, half of which were vaccinated with the Supercox vaccine comprising a precocious line of Eimeria tenella and non-attenuated lines of Eimeria maxima and Eimeria acervulina, and the other half were medicated with Diclazuril delivered as feed additive at the dosage of 1mg/kg of feed. The vaccine was administered orally to 7-day-old chickens. No clinical diseases were diagnosed in any of the vaccinated birds. However, clinical coccidiosis occurred in a large proportion of medicated control birds and these chickens had to be treated with anticoccidial drugs (Diclazuril and Toltrazuril). Comparison of production performance between vaccinated birds and medicated control birds revealed that the vaccine Supercox performed better than anticoccidial drugs in terms of mortalities, costs and overall economic benefits (profits). These findings demonstrated that the use of the Supercox vaccine could control clinical coccidiosis in broilers and achieve production performance superior to that using anticoccidial drugs, particularly where drug resistance might result in failure to control clinical diseases.
authors.affiliation: Parasitology Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100094, PR China.
authors.forename: X
authors.initials: X
authors.lastname: Suo
authors.forename: J X
authors.initials: JX
authors.lastname: Zhang
authors.forename: Z G
authors.initials: ZG
authors.lastname: Li
authors.forename: C T
authors.initials: CT
authors.lastname: Yang
authors.forename: Q R
authors.initials: QR
authors.lastname: Min
authors.forename: L T
authors.initials: LT
authors.lastname: Xu
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: X Q
authors.initials: XQ
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002645:Chickens / Q000254:growth & development; D002681:China; D003048:Coccidiosis / Q000191:economics / Q000517:prevention & control / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D005243:Feces / Q000469:parasitology; D005260:Female; D008297:Male; D009570:Nitriles / Q000627:therapeutic use; D010270:Parasite Egg Count / Q000662:veterinary; D011201:Poultry Diseases / Q000191:economics / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000191:economics / Q000276:immunology*; D011897:Random Allocation; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use; D014611:Vaccination / Q000662:veterinary
chemical_list: D003049:Coccidiostats; D009570:Nitriles; D016052:Protozoan Vaccines; D014227:Triazines; C057884:diclazuril