Neointima inhibition: comparison of effectiveness of non-stent-based local drug delivery and a drug-eluting stent in porcine coronary arteries.
OBJECTIVE
To compare the inhibition of neointimal proliferation by using non-stent-based local drug delivery and a drug-eluting stent in porcine coronary arteries.


METHODS
Experiments were conducted with permission of the animal protection committee of the local government. Paclitaxel was either dissolved in a nonionic contrast medium or coated on balloons. Stents were crimped on the coated balloons. Effectiveness was tested in 22 pigs. Two coronary stents were placed in each pig, and slight overstretch was applied. The animals were treated as follows: group A (control group), uncoated balloons, bare stents, and "plain" contrast medium; group B, same treatment as group A, but with paclitaxel in the contrast medium; group C, paclitaxel-coated balloons, with premounted bare stents and plain contrast medium; and group D, sirolimus-eluting stents, noncoated balloons, and plain contrast medium. Stenosis was assessed 4 weeks later at angiography and histomorphometry. For exploratory purposes, continuous variables of quantitative coronary angiography and histomorphometry were compared by using analysis of variance.


RESULTS
Results at follow-up angiography indicated a mean of 1.00 mm +/- 0.18 (standard deviation) lumen diameter loss in the control group and 0.14 mm +/- 0.18 loss in the group treated with the paclitaxel-coated balloon (group C; P < .001). Findings at histomorphometry confirmed the effectiveness of drug delivery, with the most impressive inhibition of neointimal proliferation from coated balloons-the neointimal area was 2.4 mm2 +/- 0.3 (P < .01 vs all other groups), compared with 5.2 mm2 +/- 0.3 in group A (control group), 4.3 mm2 +/- 0.3 in group B, and 3.8 mm2 +/- 0.3 in group D.


CONCLUSIONS
In spite of the short intima contact time, paclitaxel coated on the balloon inhibits neointimal formation in the porcine model of coronary stent placement.
Speck
Ulrich
U
Department of Radiology, Charité Humboldt-University Berlin, Schumannstr 20-21, D 10117 Berlin, Germany. ulrich.speck@charite.de
Scheller
Bruno
B
Abramjuk
Claudia
C
Breitwieser
Christoph
C
Dobberstein
Juergen
J
Boehm
Michael
M
Hamm
Bernd
B
D000704:Analysis of Variance; D000818:Animals; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects*; D016503:Drug Delivery Systems; D017239:Paclitaxel / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D020123:Sirolimus / Q000008:administration & dosage / Q000494:pharmacology*; D015607:Stents; D013552:Swine; D017539:Tunica Intima / Q000187:drug effects*
D017239:Paclitaxel; D020123:Sirolimus