[Study of correlation between renal vein renin and therapeutic effect of percutaneous renal artery stenting].
OBJECTIVE
To assess the value of renal vein renin , plasma endothelin (ET), nitric oxide (NO), calcitonin gene-related peptide (CGRP) in predicting the therapeutic effect of percutaneous renal artery stenting.


METHODS
Selective renal angiography was performed in 60 patients with coronary artery disease and hypertension. All the patients with obvious unilateral renal artery stenosis (lumen narrowing >or =50%) underwent percutaneous transluminal renal angioplasty and stenting. Bilateral renal vein and inferior vena cava plasma renin activity (PRA) and plasma ET, NO, and CGRP levels were measured and the two-year follow-up data of the patients analyzed.


RESULTS
In all the patients, PRA in the ischemic kidney was significantly higher than that in the contralateral kidney (3.89-/+3.14 vs 2.01-/+1.93 nmol/L/h, P>0.05). After renal artery revascularization with stenting, PRA in the ischemic kidney was reduced obviously (P<0.05), which was significantly lower in patients with renal vein renin ratio (RVRR)>1.5 than in those with RVRR <1.5 (1.92-/+2.15 vs 2.42-/+0.56 nmol/L/h, P<0.05]. Plasma ET level was significantly higher, whereas plasma NO level significantly lower in patients with PVRR>1.5 (P<0.05). Greater improvement of blood pressure was observed in patients with RVRR>1.5 after two years than in those with RVRR< 1.5 (P<0.05).


CONCLUSIONS
The activity of penal vein renin, plasma ET, NO, and CGRP may provide valuable information for predicting the therapeutic effect of percutaneous renal artery stenting.
Feng
Ying-qing
YQ
Department of Cardiology, People's Hospital of Guangdong Province, Guangzhou 510080, China. fyq18@hotmail.com
Zhou
Ying-ling
YL
Luo
Jian-fang
JF
Yu
Dan-qing
DQ
Chen
Ji-yan
JY
D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000601:surgery; D012078:Renal Artery Obstruction / Q000097:blood / Q000628:therapy*; D012082:Renal Veins; D012083:Renin / Q000097:blood*; D015607:Stents
D019332:Endothelin-1; D009569:Nitric Oxide; D012083:Renin; D015740:Calcitonin Gene-Related Peptide