Interactions between heparan sulfate and proteins: the concept of specificity.
Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS-protein binding. Unexpectedly, many interactions appear to depend more on the overall organization of HS domains than on their fine structure.
Kreuger
Johan
J
Rudbeck Laboratory, Department of Genetics and Pathology, Biomedical Center, Uppsala University, SE-75185 Uppsala, Sweden.
Spillmann
Dorothe
D
Li
Jin-ping
JP
Lindahl
Ulf
U
D000818:Animals; D001665:Binding Sites; D001704:Biopolymers; D006497:Heparan Sulfate / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D013379:Substrate Specificity
D001704:Biopolymers; D006497:Heparan Sulfate; D011506:Proteins