RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity.
A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).
Liebetanz
K M
KM
Department of Clinical Neurophysiology, Georg-August-University, Goettingen, Germany.
Winkelmann
J
J
Trenkwalder
C
C
Pütz
B
B
Dichgans
M
M
Gasser
T
T
Müller-Myhsok
B
B
D025063:Chromosome Disorders / Q000453:epidemiology* / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005190:Family; D005260:Female; D005799:Genes, Dominant; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005858:Germany / Q000453:epidemiology; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012148:Restless Legs Syndrome / Q000453:epidemiology* / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors