Stereotactic radiosurgery and fractionated stereotactic radiotherapy in the treatment of uveal melanoma.
Uveal melanoma is the most common primary intraocular malignant tumor. Radiation therapy has now replaced enucleation as the treatment of choice, with radioactive eye plaques and proton therapy being the two most studied radiotherapy modalities. More recently, stereotactic radiosurgery and fractionated stereotactic radiotherapy have emerged as promising, non-invasive treatments for uveal melanoma. This review summarizes the available literature on these newer treatment modalities.
Henderson
Mark A
MA
Department of Radiation Oncology, Indiana University Medical Center, Indianapolis, IN, USA.
Shirazi
Haider
H
Lo
Simon S
SS
Mendonca
Marc S
MS
Fakiris
Achilles J
AJ
Witt
Thomas C
TC
Worth
Robert M
RM
Timmerman
Robert D
RD
D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D006801:Humans; D008545:Melanoma / Q000532:radiotherapy* / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*