Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease.
Compain
Philippe
P
ICOA, UMR 6005 CNRS/Université d'Orléans rue de Chartres, Orléans, France. philippe.compain@univ-orleans.fr
Martin
Olivier R
OR
Boucheron
Charlotte
C
Godin
Guillaume
G
Yu
Liang
L
Ikeda
Kyoko
K
Asano
Naoki
N
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives / Q000737:chemistry; D002384:Catalysis; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology; D005776:Gaucher Disease / Q000188:drug therapy*; D005087:Glucan 1,4-alpha-Glucosidase / Q000037:antagonists & inhibitors / Q000737:chemistry; D005959:Glucosidases / Q000037:antagonists & inhibitors / Q000737:chemistry; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000187:drug effects; D006801:Humans; D007097:Imines / Q000737:chemistry; D014993:Xylitol / Q000031:analogs & derivatives / Q000737:chemistry
D004791:Enzyme Inhibitors; D007097:Imines; D017485:1-Deoxynojirimycin; D005959:Glucosidases; D005087:Glucan 1,4-alpha-Glucosidase; D005962:Glucosylceramidase; D014993:Xylitol