title: Osteonecrosis of the jaw and oral bisphosphonate treatment.
abstract: BACKGROUND
  Bisphosphonates are becoming recognized increasingly as having a significant impact on dental therapies. This case report describes adverse clinical sequelae and successful treatment following periodontal surgery in a dental patient receiving bisphosphonate treatment.
  
  
  METHODS
  A 78-year-old woman experienced a nonhealing interproximal wound subsequent to a minor periodontal procedure performed to facilitate restoration of an adjacent tooth. Her medical history revealed that she had been taking an oral bisphosphonate every day for the previous five years for treatment of osteoporosis. After three months of periodic débridement and meticulous oral home care, one of the authors recovered a large piece of necrotic bone. The wound healed after the author performed surgery at the site.
  
  
  CONCLUSIONS
  Dentists should exercise caution when considering surgical procedures for patients with a history of oral bisphosphonate use. Thorough treatment of nonhealing wounds in these patients can lead to favorable outcomes.
authors.affiliation: Temple University School of Dentistry, Philadelphia, USA. DrJohn@adamember.net
authors.forename: John B
authors.initials: JB
authors.lastname: Nase
authors.forename: Jon B
authors.initials: JB
authors.lastname: Suzuki
mesh_terms: D000284:Administration, Oral; D000368:Aged; D019386:Alendronate / Q000008:administration & dosage / Q000009:adverse effects*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003646:Debridement; D003731:Dental Caries / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005890:Gingivectomy; D006801:Humans; D008336:Mandibular Diseases / Q000139:chemically induced* / Q000601:surgery; D010020:Osteonecrosis / Q000139:chemically induced* / Q000601:surgery; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy
chemical_list: D050071:Bone Density Conservation Agents; D019386:Alendronate