Telomere protection: an act of God.
Telomeres are nucleoprotein structures that shelter the ends of linear chromosomes from being inappropriately recognized as DNA double-strand breaks. New work has revealed that Apollo, a nuclease previously implicated in DNA repair, also has a role in safeguarding telomeres during S phase.
Szilard
Rachel K
RK
Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Durocher
Daniel
D
D004260:DNA Repair; D045643:DNA Repair Enzymes; D005090:Exodeoxyribonucleases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D021122:Protein Subunits / Q000378:metabolism; D016196:S Phase; D000089804:Shelterin Complex; D035182:TATA Box Binding Protein-Like Proteins / Q000378:metabolism; D016615:Telomere / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000378:metabolism; D035341:Telomeric Repeat Binding Protein 2
D009687:Nuclear Proteins; D021122:Protein Subunits; D000089804:Shelterin Complex; D035182:TATA Box Binding Protein-Like Proteins; C504753:TERF2 protein, human; D034501:Telomere-Binding Proteins; D035341:Telomeric Repeat Binding Protein 2; C493741:DCLRE1B protein, human; D005090:Exodeoxyribonucleases; D045643:DNA Repair Enzymes