title: [Adjuvant effect of CpG DNA recombinant plasmid on antigen of Cysticercus cellulosae].
abstract: In order to prove the adjuvant effect of CpG DNA recombinant plasmid, the total antibodies and their IgG2a subtype induced by antigen of Cysticercus cellulosae, and content of IL-4 and IFN-gamma secreted from splenic cell of mouse immunized were measured. The recombinant plasmids showed an adjuvant effect, and CpG2 was the best adjuvant among the plasmids. It is proved that the CpG DNA possesses a synergistic effect with AI(OH)3 and 206 adjuvant, and is an effective Th1 type adjuvant in mice.
authors.affiliation: Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China.
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Jing
authors.forename: Xue-lian
authors.initials: XL
authors.lastname: Meng
authors.forename: Pei-ya
authors.initials: PY
authors.lastname: Wang
authors.forename: Yong-xi
authors.initials: YX
authors.lastname: Dou
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xue-nong
authors.initials: XN
authors.lastname: Luo
authors.forename: Ya-dong
authors.initials: YD
authors.lastname: Zheng
authors.forename: Xue-peng
authors.initials: XP
authors.lastname: Cai
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D018899:CpG Islands / Q000235:genetics; D003551:Cysticercosis / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D003552:Cysticercus / Q000276:immunology; D004247:DNA / Q000276:immunology*; D005260:Female; D007114:Immunization; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010957:Plasmids / Q000235:genetics; D011897:Random Allocation; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; D000947:Antigens, Helminth; C423450:CpG ODN 1585; D007376:Interleukin-2; D007371:Interferon-gamma; D004247:DNA