title: Sexual dysfunction in major depression.
abstract: Little is known about the prevalence, typology, and natural course of non-drug-induced sexual dysfunction in patients with depression. Loss of libido has been reported in various studies to affect from 25% to 75% of patients with unipolar depression, and its prevalence appears to be correlated with the severity of depression. Disorders of arousal also appear to be relatively common in both men and women with major depression, of whom approximately 25% may experience problems with erection or lubrication. The scant available data regarding orgasmic difficulties in patients with depression who have not yet taken antidepressant medication suggest that they are more common than in the general population. The potential causes of sexual dysfunction in patients with depression are complex and little investigated, and future research must distinguish and explore the various biological, psychological, and psychosocial factors that are likely to be involved.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, CA 94305-5723, USA. elliew@stanford.edu
authors.forename: Katherine
authors.initials: K
authors.lastname: Williams
authors.forename: Margaret F
authors.initials: MF
authors.lastname: Reynolds
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000453:epidemiology*; D007172:Erectile Dysfunction / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012735:Sexual Dysfunction, Physiological / Q000175:diagnosis / Q000209:etiology*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced
chemical_list: D000928:Antidepressive Agents