[The mechamism of L-arginine protective influence on the liver under ischemia - reperfusion conditions].
Previous investigations indicated a protective effect of L-arginine (300 mg/kg) against hepatic reperfusion injury. This was an investigation of the mechanism of this protective effect. The infusion of L-arginine under the conditions of inhibited NO synthesis (L-NAME, 10 mg/kg) significantly increased lipid peroxidation processes and transaminase activity and decreased antioxidant defense in postischemic liver. It is concluded that protective mechanism of L-arginine against hepatic reperfusion injury is associated with NO synthesis.
Khodosovskiĭ
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D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001120:Arginine / Q000008:administration & dosage*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis; D011817:Rabbits; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000637:Transaminases / Q000378:metabolism
D000975:Antioxidants; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D001120:Arginine; D000637:Transaminases; D019331:NG-Nitroarginine Methyl Ester