Ultra-sensitive and quantitative characterization of proteomes.
Electrospray ionization mass spectrometry combined with high efficiency capillary liquid chromatography provides high sensitivity and broad dynamic range measurements for the characterization of biological macromolecules in complex matrices, and is an increasingly powerful analytical tool for systems biology research.
Smith
Richard D
RD
Biological Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, MS K8-98, Richland, WA 99352, USA. rds@pnl.gov
Tang
Keqi
K
Shen
Yufeng
Y
D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008954:Models, Biological; D040901:Proteomics / Q000379:methods*; D020592:Shewanella / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods