title: Self-assembly of stimuli-responsive water-soluble [60]fullerene end-capped ampholytic block copolymer.
abstract: A well-defined, water-soluble, pH and temperature stimuli-responsive [60]fullerene (C(60)) containing ampholytic block copolymer of poly((methacrylic acid)-block-(2-(dimethylamino)ethyl methacrylate))-block-C(60) (P(MAA-b-DMAEMA)-b-C(60)) was synthesized by the atom transfer radical polymerization (ATRP) technique. The self-assembly behavior of the C(60) containing polyampholyte in aqueous solution was characterized by potentiometric and conductometric titration, dynamic light scattering (DLS), and transmission electron microscopy. This amphiphilic mono-C(60) end-capped block copolymer shows enhanced solubility in aqueous medium at room and elevated temperatures and at low and high pH but phase separates at intermediate pH between 5.4 and 8.8. The self-assembly of the copolymer is different from that of P(MAA-b-DMAEMA). Examination of the association behavior using DLS revealed the coexistence of unimers and aggregates at low pH at all temperatures studied, with the association being driven by the balance of hydrophobic and electrostatic interactions. Unimers and aggregates of different microstructures are also observed at high pH and at temperatures below the lower critical solution temperature (LCST) of PDMAEMA. At high pH and at temperatures above the LCST of PDMAEMA, the formation of micelles and aggregates coexisting in solution is driven by the combination of hydrophobic, electrostatic, and charge-transfer interactions.
authors.affiliation: School of Mechanical and Aerospace Engineering and Division of Chemical and Biomolecular Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Republic of Singapore.
authors.forename: Soon Kay
authors.initials: SK
authors.lastname: Teoh
authors.forename: Palaniswamy
authors.initials: P
authors.lastname: Ravi
authors.forename: Sheng
authors.initials: S
authors.lastname: Dai
authors.forename: Kam Chiu
authors.initials: KC
authors.lastname: Tam
mesh_terms: D002850:Chromatography, Gel; D004553:Electric Conductivity; D037741:Fullerenes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D011108:Polymers; D019904:Polymethyl Methacrylate / Q000737:chemistry; D011199:Potentiometry; D012995:Solubility; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D037741:Fullerenes; D011108:Polymers; D012996:Solutions; D019904:Polymethyl Methacrylate