Determination of p-aminosalicylic acid and m-aminophenol by derivative UV-spectrophotometry.
A direct method for the simultaneous determination of p-aminosalicylic acid (PAS) and its major decomposition product, m-aminophenol (MAP), is described. The analysis is based on the use of derivative UV-spectrophotometry and is a rapid procedure which gives accurate and precise results. A simple purity test which utilizes the third derivative spectrum is also reported and compared with the USP XX spectrophotometric method for the estimation of MAP in PAS formulations.
Vetuschi
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Dipartimento Farmaco-Chimico dell'Università, Via Amendola 173, 70126 Bari, Italy.
Ragno
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Mazzeo
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