[Effects of afobazole on the BDNF content in brain structures of inbred mice with different phenotypes of emotional stress reaction].
Changes in the BDNF content in brain structures--hippocampus, hypothalamus, striatum, and frontal cortex--were determined in mice of different emotional-stress reaction phenotypes, which were subjected to emotional stress and treated by the selective anxiolytic afobazole. The changes were different in BALB/c and C57BL/6 mice. Afobazole exhibited a significant protector action against a decrease in the brain BDNF level caused by emotional stress in BALB/c mice.
Seredin
S B
SB
Melkumian
D S
DS
Val'dman
E A
EA
Iarkova
M A
MA
Seredina
T C
TC
Voronin
M V
MV
Lapitskaia
A S
AS
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001562:Benzimidazoles / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009025:Morpholines / Q000494:pharmacology*; D010641:Phenotype; D013315:Stress, Psychological / Q000378:metabolism*
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D019208:Brain-Derived Neurotrophic Factor; D009025:Morpholines