Qualitative aspects of the degradation of mitomycins in alkaline solution.
The major degradation product in alkaline solution of mitomycin A, mitomycin C and porfiromycin is the corresponding 7-hydroxymitosane. The isolation and the physico-chemical and analytical properties of these compounds and their derivatized analogues are discussed. Data are presented on the degradation of mitomycin C at extremely high pH values.
Beijnen
J H
JH
Department of Analytical Pharmacy, Subfaculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511 GH Utrecht, The Netherlands.
den Hartigh
J
J
Underberg
W J
WJ