title: The use of a dispersive ground electrode with a loosely wound helical coil for interstitial radiofrequency thermal therapy.
abstract: We have developed a novel, thermal therapy device designed to improve local control of large solid tumours using heat in the range 55-90 degrees C. The device is a helical coil designed to be loosely wound inside a tumour and excited with radiofrequency energy at 27.12 MHz. This design exploits the size and uniformity of the electric fields generated by magnetic induction inside this solenoidal geometry for heating and coagulating a large target volume. The use of the electrically conductive shape memory alloy Nitinol for the coil and an external ground plane permit the minimally invasive percutaneous insertion of the coil through a single cannulating delivery needle. To demonstrate the feasibility of this device, phantom models and finite-element models using COMSOL 3.2 were used to characterize uniformity of the radial and axial ARD (absorption rate density) profiles of different monopolar coil geometries. COMSOL 3.2 was also used to calculate temperature profiles and distributions produced by these coils in a non-perfused tissue-mimicking domain following a 10 min heating period. ARD results showed that optimum radial and axial uniformities were achieved with a 0.75 cm pitch and 3 cm length for a 1.5 cm diameter coil, and a 1.4 cm pitch and 4.2 cm length for a 2 cm diameter coil. These coils were able to produce lesions in excised bovine liver of 4 cm x 4.5 cm and 3.5 cm x 6.5 cm, respectively. Predicted temperature profiles showed similar profile sizes and shapes in a non-perfused domain, with the absolute temperature rise determined by the source input to the coil. These results demonstrate the potential of this interstitial, monopolar induction coil device for heating large tumours using a single applicator delivered through a single needle insertion.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, 610 University Avenue, Toronto, ON M5G 2M9, Canada. cmccann@uhnres.utoronto.ca
authors.forename: Claire
authors.initials: C
authors.lastname: McCann
authors.forename: Michael D
authors.initials: MD
authors.lastname: Sherar
mesh_terms: D000497:Alloys / Q000737:chemistry; D000818:Animals; D002417:Cattle; D003972:Diathermy / Q000295:instrumentation* / Q000379:methods; D004553:Electric Conductivity; D004574:Electromagnetic Fields; D004867:Equipment Design; D006358:Hot Temperature; D006979:Hyperthermia, Induced / Q000295:instrumentation* / Q000379:methods; D015233:Models, Statistical; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D011846:Radio Waves; D013696:Temperature
chemical_list: D000497:Alloys; C013616:nitinol