title: Association of nasopharyngeal and laryngopharyngeal reflux with postnasal drip symptomatology in patients with and without rhinosinusitis.
abstract: BACKGROUND
  Patients often report postnasal drip (PND), but objective rhinosinusitis and allergy findings are frequently absent. In this study, we evaluate the association between PND and pharyngeal reflux.
  
  
  METHODS
  Sixty-eight participants underwent 24-hour pH testing, including chronic rhinosinusitis (CRS) patients persistently symptomatic after endoscopic sinus surgery, CRS patients successfully treated by endoscopic sinus surgery, and volunteers without a CRS history. The pH probes contained nasopharyngeal (NP), laryngopharyngeal (LP), and distal esophageal sensors. Participants completed the Sinonasal Outcome Test-20 (SNOT-20) and Modified Reflux Symptom Index (MRSI) questionnaires. Survey items addressing PND symptomatology were compared with NP reflux (NPR) below pH 4 and pH 5 (defined as > or = 1 event), and LP reflux (LPR; defined as > or = 7 events or reflux area index > 6.3).
  
  
  RESULTS
  Pearson analyses revealed a positive correlation of r = 0.87 between SNOT-20 and MRSI PND items. For NPR < pH 4, no significant difference existed between participants with and without reflux on the SNOT-20 or MRSI (p > 0.05). However, for NPR < pH 5, reflux-positive participants exhibited significantly more PND symptoms on the SNOT-20 (p = 0.030) and the MRSI (p = 0.018) compared with participants without reflux. Finally, participants with LPR had significantly more PND symptomatology on the SNOT-20 (p = 0.010) versus those without LPR. A borderline significant difference existed on the MRSI PND item between participants positive and negative for LPR (p = 0.055).
  
  
  CONCLUSIONS
  Objective evidence of NPR and LPR exists in patients reporting PND. Reflux treatment may reduce PND complaints.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Emory Clinic, 1365A Clifton Road NE, Suite 2100, Atlanta, GA 30322, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Wise
authors.forename: Justin C
authors.initials: JC
authors.lastname: Wise
authors.forename: John M
authors.initials: JM
authors.lastname: DelGaudio
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D007013:Hypopharynx / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009302:Nasopharyngeal Diseases / Q000453:epidemiology*; D010608:Pharyngeal Diseases / Q000453:epidemiology*; D012220:Rhinitis / Q000453:epidemiology*; D012852:Sinusitis / Q000453:epidemiology*