title: Lutheran b blood group alloimmunization: case series and literature review.
abstract: The Lutheran b blood antigen is a high prevalence antigen occurring in 99.8% of Caucasians. Consequently, antibody formation against Lutheran b is very rare. While this antibody can cause hemolytic reactions in adults, there is limited clinical information on its effects on the fetus and newborn. As a high prevalence antigen, it may be difficult to obtain Lutheran b-negative blood for possible maternal transfusion. We describe two cases of pregnancy complicated by Lutheran b alloimmunization. These cases highlight the potential fetal and maternal complications associated with this antibody and we review options to maximize perinatal outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Bridgeport Hospital, USA.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Kashani
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Stiller
mesh_terms: D000328:Adult; D000941:Antigens / Q000276:immunology*; D005260:Female; D006801:Humans; D008188:Lutheran Blood-Group System; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D014481:United States
chemical_list: D000941:Antigens; D008188:Lutheran Blood-Group System