title: First total synthesis of louisianin A.
abstract: The first total synthesis of louisianin A, 4-allyl-6,7-dihydro-1-hydroxycyclopenta[c]pyridin-5-one, is achieved from 2-chloro-4-cyanopyridine 5 via seven steps in an overall 24% yield. The key step is a cyclization-decarboxylation sequence toward the formation of a cyclopentenone ring.
authors.affiliation: Department of Biotechnology and Bioinformatics, Asia University, Wufeng, Taichung, 413, Taiwan, Republic of China. cychang@asia.edu.tw
authors.forename: Ching-Yao
authors.initials: CY
authors.lastname: Chang
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Liu
authors.forename: Tahsin J
authors.initials: TJ
authors.lastname: Chow
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000498:Allyl Compounds; D011725:Pyridines; C096930:louisianin A