Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication.
Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (<or=0.5 mg ml(-1)) and no significant cytotoxic effects were observed in vitro.
Li
Yue-Qing
YQ
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhongshan Road, BOX 90, Dalian, Liaoning Province 116012, China.
Li
Ze-Lin
ZL
Zhao
Wei-Jie
WJ
Wen
Rui-Xing
RX
Meng
Qing-Wei
QW
Zeng
Yi
Y
D000818:Animals; D002522:Chlorocebus aethiops; D015394:Molecular Structure; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects* / Q000502:physiology*; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
D013267:Stilbenes