title: Antiplatelet agents, carotid endarterectomy, and perioperative complications.
abstract: Neurosurgeons are frequently involved in choosing an antiplatelet therapy for their patients in the perioperative period. New data obtained from the Aspirin and Carotid Endarterectomy (ACE) Trial suggest that low-dose aspirin is superior to high-dose aspirin therapy in reducing rates of perioperative stroke and death. The ACE-related data are reviewed, and the authors provide an update on current Food and Drug Administration-approved antiplatelet therapies for secondary stroke prevention, as well as a summary of antiplatelet therapies being developed.
authors.affiliation: Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA. bbw9r@virginia.edu
authors.forename: B B
authors.initials: BB
authors.lastname: Worrall
authors.forename: K C
authors.initials: KC
authors.lastname: Johnston
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D016894:Endarterectomy, Carotid / Q000009:adverse effects; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D008954:Models, Biological; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin