Delivery of chemotherapy and antibodies across the blood-brain barrier and the role of chemoprotection, in primary and metastatic brain tumors: report of the Eleventh Annual Blood-Brain Barrier Consortium meeting.
Although knowledge of molecular biology and cellular physiology has advanced at a rapid pace, much remains to be learned about delivering chemotherapy and antibodies across the blood-brain barrier (BBB) for the diagnosis and treatment of central nervous system (CNS) disease. A meeting, partially funded by an NIH R13 grant, was convened to discuss the state of the science, current knowledge gaps, and future directions in the delivery of drugs and proteins to the CNS, for the treatment of primary and metastatic brain tumors. Meeting topics included CNS metastases and the BBB, and chemoprotection and chemoenhancement in CNS disorders. The discussions regarding CNS metastases generated possibilities of chemoprotection as a means not only to decrease treatment-related toxicity but also to increase chemotherapy dose intensity. The increasing incidence of sanctuary brain metastasis from breast cancer, in part due to the difficulty of monoclonal antibodies (mAbs) such as herceptin to cross the BBB, was one of the most salient "take home" messages of the meeting.
Doolittle
Nancy D
ND
Department of Neurology, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road-L603, Portland, OR 97239-3098, USA.
Peereboom
David M
DM
Christoforidis
Gregory A
GA
Hall
Walter A
WA
Palmieri
Diane
D
Brock
Penelope R
PR
Campbell
Kathleen C M
KC
Dickey
D Thomas
DT
Muldoon
Leslie L
LL
O'Neill
Brian Patrick
BP
Peterson
Darryl R
DR
Pollock
Brad
B
Soussain
Carole
C
Smith
Quentin
Q
Tyson
Rose Marie
RM
Neuwelt
Edward A
EA
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000556:secondary / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007223:Infant; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D020258:Neurotoxicity Syndromes / Q000517:prevention & control
D000970:Antineoplastic Agents