[The effects of the GH, IGF-I and IGF-IBP3 gene on growth and development traits of Nanyang cattle in different growth period].
This study was conducted to identify polymorphisms of the Nangyang cattle's growth hormone (GH) and insulin-like growth factor-I (IGF-I) and insulin-like growth factor-I binding protein 3(IGF-IBP3) gene by the single nucleotide Polymorphisms and Polymerase chain reaction-based restriction fragment length polymorphism and to study association of polymorphisms identified in these genes with growth traits of the birth, 6 months, 12 months, 18 months, 24 months and 36 months. Results from the analysis showed a significant association of the BB genotype in the promoter of GH gene (GH-P5) with higher body length and body height during from 6 month to 18 month. From 24 month to 36 month, the IGF-IBP3 locus has a dominance modulation and control effect on backbody in Nanyang Cattle, and the BB genotype with higher Rump width than AA.
Gao
Xue
X
The Institute of Animal Science, Chinese Academic Agriculture Science, Beijing 100094, China. gaoxueyl@163.net
Xu
Xiu-Rong
XR
Ren
Hong-Yan
HY
Zhang
Ying-Han
YH
Xu
Shang-Zhong
SZ
D000818:Animals; D001835:Body Weight; D002417:Cattle / Q000033:anatomy & histology / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D002681:China; D005838:Genotype; D013006:Growth Hormone / Q000235:genetics* / Q000378:metabolism; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics* / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone