Strict preparation and evaluation of water-soluble hat-stacked carbon nanofibers for biomedical application and their high biocompatibility: influence of nanofiber-surface functional groups on cytotoxicity.
Water-soluble H-CNFs modified with a carboxyl group possessed the ability to induce TNF-alpha, whereas CHAPS-treated H-CNFs possessed significantly greater activity and were also found to activate NF-kappaB reporter activity, to a significantly greater level than H-CNFs; furthermore the functional group modified or coated on the surface of H-CNFs was a significant cytotoxic factor that affected cell activation.
Sato
Yoshinori
Y
Graduate School of Environmental Studies, Tohoku Univesity, Aramaki, Sendai, Japan. hige@buckyl.tohoku.ac.jp
Shibata
Ken-ichiro
K
Kataoka
Hideo
H
Ogino
Shin-ichi
S
Bunshi
Fugetsu
F
Yokoyama
Atsuro
A
Tamura
Kazuchika
K
Akasaka
Tsukasa
T
Uo
Motohiro
M
Motomiya
Kenichi
K
Jeyadevan
Balachandran
B
Hatakeyama
Rikizo
R
Watari
Fumio
F
Tohji
Kazuyuki
K
D002244:Carbon / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014867:Water / Q000737:chemistry
D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D014867:Water; D002244:Carbon