A modular approach to the synthesis of 2,3,4-trisubstituted tetrahydrofurans.
A highly diastereoselective Lewis acid-mediated [1,3] rearrangement of 1,3-dioxepins is the key step along a modular route to 2,3,4-trisubstituted tetrahydrofurans.
Nasveschuk
Christopher G
CG
Department of Chemistry, Colorado State University, Fort Collins, CO, USA.
Jui
Nathan T
NT
Rovis
Tomislav
T
D000143:Acids / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000143:Acids; D005663:Furans; C018674:tetrahydrofuran