title: Protein driven patterning of self-assembled cubosomic nanostructures: long oriented nanoridges.
abstract: Self-assembly lipid/protein cubosomic nanostructures are generated at high hydration level (dispersion of 5% lipid only) and examined by freeze-fracture electron microscopy (FF-EM) and synchrotron X-ray diffraction (XRD). The fracture surface of the three-dimensional (3D) soft-matter membranous assembly reveals starlike nanopatterns of oriented 100-nm-long cubosomic nanoridges with lateral periodicity defined by their 21-nm diameters. The average water channel radius in these liquid crystalline cubosomic nanoarchitectures, determined by high-resolution FF-EM and XRD, is 18.0 Angstrom. The protein-directed fragmentation of a diamond-type lipid cubic phase at high hydration can induce 3D patterns of oriented nanoporous building blocks, which are a unique example of tertiary organization of functionalized fluid lipid/water interfaces.
authors.forename: Angelina
authors.initials: A
authors.lastname: Angelova
authors.forename: Borislav
authors.initials: B
authors.lastname: Angelov
authors.forename: Brigitte
authors.initials: B
authors.lastname: Papahadjopoulos-Sternberg
authors.forename: Claudie
authors.initials: C
authors.lastname: Bourgaux
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
mesh_terms: D002627:Chemistry, Physical / Q000379:methods*; D005614:Freeze Fracturing; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008055:Lipids / Q000737:chemistry; D008956:Models, Chemical; D015233:Models, Statistical; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D008055:Lipids; D011506:Proteins