Subclinical left ventricular dysfunction in multiple sclerosis.
OBJECTIVE
To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI).


METHODS
A total of 41 patients with definite MS and 32 healthy controls were included in the study.


RESULTS
LV end-systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls (P < 0.05). LV end-diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance.


CONCLUSIONS
These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS.
Akgül
Ferit
F
Mustafa Kemal University, Faculty of Medicine, Department of Cardiology, Antakya, Turkey. feritakgul1@yahoo.ca
McLek
Ismet
I
Duman
Taşkin
T
Seyfelì
Ergün
E
Seydaliyeva
Tunzale
T
Yalçin
Fatih
F
D000328:Adult; D002303:Cardiac Output, Low / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology*; D009205:Myocarditis / Q000000981:diagnostic imaging / Q000276:immunology / Q000503:physiopathology; D009206:Myocardium / Q000276:immunology*; D011237:Predictive Value of Tests; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*