Effects of dietary apple polyphenol on adipose tissues weights in Wistar rats.
In this study, we investigated whether dietary apple polyphenol (APP) had an effect on adipose weights.Twenty-four Wistar male rats (10 weeks of age) were assigned to three groups: (1) the 5%APP group (diet containing 5% APP, N=8); (2) the 0.5%APP group (diet containing 0.5% APP, N=8); and (3) the control group (N=8) so that average weights of the groups were the same. After a three-week experimental period, adipose tissue weights were measured. Pathological and plasma characteristics were also examined. Retroperitoneal and epididymal adipose tissue weights in the 5%APP group were significantly lower than those of the control (P<0.05). Pathological examination showed that form-like cells were observed only in the control group, suggesting the existence of proliferating pre-adipocytes only in the control group. Lipid-related plasma profiles showed no statistical differences. Dietary polyphenol did not induce any anorectic effects as reported in studies concerning tea polyphenol. We conclude that dietary APP has an anti-adipogenic effect in Wistar rats without any anorectic phenomenon.
Nakazato
Koichi
K
Department of Exercise Physiology, Graduate School of Health and Sport Science, Nippon Sport Science University, 7-1-1 Fukasawa, Setagaya-ku, Tokyo 158-0081, Japan.
Song
Hongsun
H
Waga
Toshiaki
T
D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D004032:Diet; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D027845:Malus / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D005230:Fatty Acids, Nonesterified; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D014280:Triglycerides; D002784:Cholesterol