title: Complex wound management utilizing an artificial dermal matrix.
abstract: The benefits of the Integra Dermal Regeneration Template in the management of extensive burn injuries have been well documented. Integra can reduce donor- and graft-site scarring and has been reported to be capable of vascularizing over small areas of exposed bone and tendon. Given these potential advantages, we have used Integra for a variety of other reconstruction applications. We performed a retrospective review of patients with complex wounds treated with Integra at our burn center. Integra was used in the management of a variety of wounds, including necrotizing fasciitis, extremity degloving injury, meningococcemia, Marjolin ulcer, postburn lip reconstruction, and fourth-degree burns with exposed bone or tendon. Engraftment rates of Integra and autograft were 98% +/- 4% and 97% +/- 4%, respectively. All areas of graft loss healed without need for regrafting. The benefits of Integra in the management of acute burn wounds can be extended to other traumatic and complex wounds.
authors.affiliation: Burn Center, Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA.
authors.forename: Pornprom
authors.initials: P
authors.lastname: Muangman
authors.forename: Loren H
authors.initials: LH
authors.lastname: Engrav
authors.forename: David M
authors.initials: DM
authors.lastname: Heimbach
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Harunari
authors.forename: Shari
authors.initials: S
authors.lastname: Honari
authors.forename: Nicole S
authors.initials: NS
authors.lastname: Gibran
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Klein
mesh_terms: D000293:Adolescent; D000328:Adult; D002809:Chondroitin Sulfates; D003094:Collagen; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017695:Soft Tissue Injuries / Q000628:therapy*
chemical_list: C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen