Simultaneous multiwavelength spectrophotometric quantitation of active components in analgesic formulations. Comparative study of three calculation methods.
This work deals with the UV spectrophotometric quantitation of a mixture of compounds with overlapped spectra. The mixture spectrum is resolved by use of three computational programs based on different algorithms, namely Multicomponent Analysis (commercial software available from Hewlett-Packard), MULTIC (relying on multiple regression analysis) and SIMPLEX. The results obtained for mixtures of acetylsalicylic acid, acetaminophen and caffeine in commercial analgesic formulations, are compared.
Sala
G
G
Department of Chemistry, Analytical Chemistry Laboratory, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Maspotch
S
S
Iturriaga
H
H
Blanco
M
M
Cerda
V
V