title: A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida.
abstract: Investigation of an acetone extract from Asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappaB-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.
authors.affiliation: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy. appendino@pharm.unipmn.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Lucia
authors.initials: L
authors.lastname: Maxia
authors.forename: Marcelo
authors.initials: M
authors.lastname: Bascope
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Houghton
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Sanchez-Duffhues
authors.forename: Eduardo
authors.initials: E
authors.lastname: Muñoz
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003106:Colon / Q000187:drug effects; D005309:Ferula / Q000737:chemistry*; D007194:India; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D010946:Plants, Medicinal / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016328:NF-kappa B; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; C513463:fetidone A; C513464:fetidone B