title: FOLFOX4 in advanced colorectal cancer: a monoinstitutional experience.
abstract: OBJECTIVE
  Patients included in clinical trials are "selected", and they usually differ from those commonly treated.
  
  
  METHODS
  From 1999 to 2004, in the Medical Oncology Department of Padua (Italy), 70 metastatic colorectal cancers were treated with FOLFOX4.
  
  
  RESULTS
  Our results, compared with those of the registration trial (response rate, duration of response and progression-free survival) appeared lower; overall survival was improved.
  
  
  CONCLUSIONS
  The number of therapeutic regimens more than their type influenced the results.
authors.affiliation: Operative Unit of Medical Oncology, Istituto Oncologico Veneto, Padua, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Boscolo
authors.forename: Lara Maria
authors.initials: LM
authors.lastname: Pasetto
authors.forename: Antonio
authors.initials: A
authors.lastname: Jirillo
authors.forename: Silvio
authors.initials: S
authors.lastname: Monfardini
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018572:Disease-Free Survival; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil