title: Characterization of moderator assembly dimension for accelerator boron neutron capture therapy of brain tumors using 7Li(p, n) neutrons at proton energy of 2.5 MeV.
abstract: The characteristics of moderator assembly dimension are investigated for the usage of 7Li(p,n) neutrons by 2.5 MeV protons in boron newtron capture therapy (BNCT) of brain tumors in the present study. The indexes checked are treatable protocol depth (TPD), which is the greatest depth of the region satisfying the dose requirements in BNCT protocol, proton current necessary to complete BNCT by 1 h irradiation, and the heat flux deposited in the Li target which should be removed. Assumed materials are D2O for moderator, and mixture of polyethylene and LiF with 50 wt % for collimator. Dose distributions have been computed with MCNP 4B and 4C codes. Consequently, realized TPD does not show a monotonical tendency for the Li target diameter. However, the necessary proton current and heat flux in the Li target decreases as the Li target diameter increases, while this trend reverses at around 10 cm of the Li target diameter for the necessary proton current in the condition of this study. As to the moderator diameter, TPD does not exhibit an apparent dependence. On the other hand, necessary proton current and heat flux decrease as the moderator diameter increases, and this tendency saturates at around 60 cm of the moderator diameter in this study. As to the collimator, increase in inner diameter is suitable from the viewpoint of increasing TPD and decreasing necessary proton current and heat flux, while these indexes do not show apparent difference for collimator inner diameters over 14 cm for the parameters treated here. The practical viewpoint in selecting the parameters of moderator assembly dimension is to increase TPD, within the technically possible condition of accelerated proton current and heat removal from the Li target. In this process, the values for which the resultant characteristics mentioned above saturate or reverse would be important factors.
authors.affiliation: Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi-Minami-ku, Hiroshima, 834-8553, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Tooru
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Gerard
authors.initials: G
authors.lastname: Bengua
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Endo
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hoshi
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000295:instrumentation / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007554:Isotopes; D008094:Lithium / Q000737:chemistry*; D009502:Neutrons / Q000627:therapeutic use*; D010315:Particle Accelerators / Q000295:instrumentation*; D011522:Protons; D011879:Radiotherapy Dosage
chemical_list: D007554:Isotopes; D011522:Protons; D008094:Lithium