Inflammatory bowel disease--environmental modification and genetic determinants.
Inflammatory bowel disease (IBD) is a complex disease, controlled by multiple risk factors that evolve and interact together. In a genetically susceptible host, there are multiple processing steps controlled by the host and the environment, from environmental exposure to the clinical and biological expression of IBD-related phenotypes. This article discusses the recent genetic discoveries, along with the proposed environmental risk factors that have been implicated in IBD. Technical advances of the HapMap project and the promise of whole genome association scans have given hopes for clarifying gene-environmental interactions in IBD that ultimately lead to a clearer understanding of the pathogenesis.
Kugathasan
Subra
S
Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. skuga@mcw.edu
Amre
Devendra
D
D002648:Child; D002874:Chromosome Mapping; D004777:Environment; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors