title: Staphylococcal vaccines and immunotherapy: to dream the impossible dream?
abstract: Staphylococcal infections not only remain an important cause of morbidity and mortality in both the community and the clinic, but the emergence of a global pandemic of community-associated methicillin-resistant Staphylococcus aureus, involving what purports to be a more virulent strain of this organism, has also led several in the infectious disease community to call for improved disease prevention strategies (in addition to novel therapeutics) in what could be thought of as the microbiological version of pre-emption. In this case, Staphylococcus aureus possesses "weapons of mass destruction" and appears to be using them effectively as part of anti-immunization insurgency.
authors.affiliation: Wyeth Research, 87 Cambridgepark Drive, Cambridge MA 02140, USA. projans@wyeth.com
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Projan
authors.forename: Mirjana
authors.initials: M
authors.lastname: Nesin
authors.forename: Paul M
authors.initials: PM
authors.lastname: Dunman
mesh_terms: D018829:Adhesins, Bacterial / Q000276:immunology; D006801:Humans; D007114:Immunization; D007167:Immunotherapy; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013209:Staphylococcal Vaccines / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*
chemical_list: D018829:Adhesins, Bacterial; D013209:Staphylococcal Vaccines; C048165:adhesin, Staphylococcus aureus