A convergent synthesis of new beta-turn mimics by click chemistry.
Alkyne-azide cycloaddition ("click" chemistry) between two peptide strands derivatized with terminal azide and alkyne, respectively, provides an efficient convergent synthesis of triazole ring-based new beta-turn mimics.
Oh
Keunchan
K
Department of Chemistry, 1120 Natural Sciences 2, University of California, Irvine, CA 92697-2025, USA.
Guan
Zhibin
Z
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D008968:Molecular Conformation; D018716:Molecular Mimicry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D010456:Peptides, Cyclic; D014230:Triazoles