Study on mutagenic effects of bisphenol A diglycidyl ether (BADGE) and its derivatives in the Escherichia coli tryptophan reverse mutation assay.
The di-epoxy compound bisphenol A diglycidyl ether (BADGE), its first and second hydrolysis products (BADGE.H2O and BADGE.2H2O, respectively) and its bis-chlorohydrin derivative (BADGE.2HCl) were examined for their mutagenicity in the Escherichia coli tryptophan reverse mutation test with strains WP2, WP2uvrA and IC3327. The assays were performed in the presence and absence of exogenous metabolic activation (S9 fraction from rat liver). The di-epoxy compound BADGE was able to induce mutagenic effects in strains WP2uvrA and IC3327 and the epoxy-diol BADGE.H2O also showed a positive response with these strains, although the latter was less potent than the former. On the other hand, the lack of mutagenic activity of BADGE.2H2O and BADGE.2HCl was also demonstrated.
Sueiro
Rosa Ana
RA
Laboratorio de Microbioloxía, Instituto de Investigación e Análises Alimentarias, Universidade de Santiago de Compostela, Campus Sur s/n, 15782 Santiago de Compostela, Spain. mprosaan@usc.es
Suárez
Susanna
S
Araujo
Manuel
M
Garrido
Manuel Joaquín
MJ
D001559:Benzhydryl Compounds; D002273:Carcinogens / Q000737:chemistry / Q000633:toxicity; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D004852:Epoxy Compounds / Q000737:chemistry / Q000633:toxicity*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D015394:Molecular Structure; D009152:Mutagenicity Tests / Q000379:methods; D009154:Mutation / Q000187:drug effects* / Q000235:genetics; D014364:Tryptophan / Q000235:genetics*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D002273:Carcinogens; D004852:Epoxy Compounds; D014364:Tryptophan; C019273:bisphenol A diglycidyl ether; D000098826:Bisphenol A Compounds