title: Aggressive periodontitis in a 16-year-old Ghanaian adolescent, the original source of Actinobacillus actinomycetemcomitans strain HK1651 - a 10-year follow up.
abstract: The highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans is strongly associated with periodontitis in adolescents. Availability of the DNA sequence of the complete genome of A. actinomycetemcomitans strain HK1651, a representative strain of the JP2 clone (http://www.genome.ou.edu/act.html), has provided new possibilities in basic research regarding the understanding of the pathogenesis of A. actinomycetemcomitans in periodontitis. This case report describes the periodontal treatment of the original source of A. actinomycetemcomitans HK1651, a 16-year-old Ghanaian adolescent girl with aggressive periodontitis. The bacterial examination involved polymerase chain reaction analysis for presence of JP2 and non-JP2 types of A. actinomycetemcomitans. The treatment, including periodontal surgery supplemented by antibiotics, arrested the progression of periodontitis for more than 10 years. Initially, infection by A. actinomycetemcomitans, including the JP2 clone, was detected at various locations in the oral cavity and was not limited to the periodontal pockets. Post-therapy, the JP2 clone of A. actinomycetemcomitans disappeared, while the non-JP2 types of A. actinomycetemcomitans remained a part of the oral microflora.
authors.affiliation: Department of Community Oral Health and Pediatric Dentistry, School of Dentistry University of Aarhus, Denmark. dhaubek@odont.au.dk
authors.forename: D
authors.initials: D
authors.lastname: Haubek
authors.forename: A
authors.initials: A
authors.lastname: Havemose-Poulsen
authors.forename: J
authors.initials: J
authors.lastname: Westergaard
mesh_terms: D000293:Adolescent; D016976:Aggregatibacter actinomycetemcomitans / Q000235:genetics*; D010520:Aggressive Periodontitis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging; D005098:Exotoxins / Q000032:analysis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000032:analysis; D008336:Mandibular Diseases / Q000000981:diagnostic imaging; D008439:Maxillary Diseases / Q000000981:diagnostic imaging; D010514:Periodontal Pocket / Q000382:microbiology; D011859:Radiography
chemical_list: D005098:Exotoxins; D007166:Immunosuppressive Agents; C018579:leukotoxin