title: Folliculotropic mycosis fungoides with follicular mucinosis--case report.
abstract: Reports on clinical and histologic follicular alterations in patients previously diagnosed with mycosis fungoides (MF) or at the time of MF diagnosis are rare. The clinical and histologic criteria to distinguish MF associated with follicular mucinosis from follicular MF are a matter of debate. A patient is described with advanced clinical and histologic alterations predominated by follicular lesions and presence of mucin. In the early stage of the disease, folliculotropism was clinically and histologically present but less pronounced than epidermotropism and classic plaque-like lesions. The patient died four years after the diagnosis. As the term 'folliculotropic' describes a particular histopathologic finding, we consider it correct to use the term "folliculotropic MF" to denote atypical lymphocyte folliculotropism in the absence or presence of mild epidermotropism, presence of mucin, or no evidence for intrafollicular mucin. Folliculotropic MF seems to represent a specific clinicopathologic entity which may have a poorer prognosis than classic MF.
authors.affiliation: University Department of Dermatology and Venereology, Zagreb University Hospital Center, Salata 4 HR-10000 Zagreb, Croatia. sodarakaj@yahoo.com
authors.forename: Jaka
authors.initials: J
authors.lastname: Rados
authors.forename: Ivan
authors.initials: I
authors.lastname: Dobrić
authors.forename: Aida
authors.initials: A
authors.lastname: Pasić
authors.forename: Davorin
authors.initials: D
authors.lastname: Loncarić
authors.forename: Ivana
authors.initials: I
authors.lastname: Manola
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D000507:Mucinosis, Follicular / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D009182:Mycosis Fungoides / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D011701:PUVA Therapy; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones; D017255:Acitretin; D008727:Methotrexate