title: [Low dose whole lung irradiation for intractable pleural effusion due to idiopathic myelofibrosis].
abstract: A 63-year-old man with idiopathic myelofibrosis, diagnosed on Sept. 2004 and treated with hydroxyurea (HU), was admitted to our hospital on March 2005 because of dyspnea and pleural effusion on the right side. Effusion analysis revealed hemothorax due to extramedullary hematopoiesis or bleeding. We performed a thoracoscopic pleural lung biopsy and pleurodesis with minocycline after surgical evacuation. However, bilateral pleural effusion appeared only 2 weeks later, which was thought to be extramedullary hematopoiesis or acute transformation. We adopted a treatment strategy with low dose whole lung irradiation (4.25 Gy/5 fractions) which was followed by complete disappearance of the bilateral pleural effusion. Our present case suggests that low dose whole lung irradiation may be an effective and safe therapy for intractable pleural effusion due to extramedullary hematopoiesis.
authors.affiliation: Department of Hematology, Nippon Medical School.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Wakita
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okabe
authors.forename: Junko
authors.initials: J
authors.lastname: Takeuchi
authors.forename: Hayato
authors.initials: H
authors.lastname: Tamai
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kenji
authors.initials: K
authors.lastname: Tajika
authors.forename: Koiti
authors.initials: K
authors.lastname: Inokuchi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Dan
mesh_terms: D006411:Hematopoiesis, Extramedullary; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D008168:Lung / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy*; D055728:Primary Myelofibrosis / Q000150:complications*; D011879:Radiotherapy Dosage
chemical_list: D006918:Hydroxyurea