title: O-methyl nakafuran-8 lactone, a new sesquiterpenoid from a hainan marine sponge Dysidea sp.
abstract: A new sesquiterpenoid, O-methyl nakafuran-8 lactone (1) has been isolated from a Hainan sponge Dysidea sp. and the structure of the new compound proposed by spectral data, was confirmed by X-ray diffraction analysis. The complete 1H- and 13C-NMR assignments were made on the basis of detailed 2D NMR spectral analysis. Compound 1 showed strong inhibitory bioactivity against PTP1B with IC50 value of 1.58 microM.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang High-Tech Park, Shanghai 201203, China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Shao
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: C J
authors.initials: CJ
authors.lastname: Sim
authors.forename: J-Y
authors.initials: JY
authors.lastname: Li
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Li
authors.forename: F-J
authors.initials: FJ
authors.lastname: Nan
authors.forename: Y-W
authors.initials: YW
authors.lastname: Guo
mesh_terms: D000818:Animals; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014961:X-Ray Diffraction
chemical_list: C517562:O-methyl nakafuran-8 lactone; D012717:Sesquiterpenes; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases