[Occurrence of plasmic and platelet prothrombotic polymorphisms in women in childbirth].
METHODS
Plasmic pro-thrombotic factors as well as pro-thrombotic platelet glycoprotein mutations have been shown to play an important role in the mechanism of the thrombo-embolic disease. However, there is no published study evaluating the role of above mentioned genetic factors in the thrombo-embolic episodes in women in childbirth.


OBJECTIVE
The aim of the study was to evaluate the role of selected genetic factors in appearance of thrombo-embolic complications in the women in childbirth, and to determine if there is the coexistence of selected platelet glycoprotein polymorphisms and factor V Leiden mutations.


METHODS
71 cases of women in child birth with thrombo-embolic disease were analyzed. Selected demographic characteristics, and genetic pro-thrombotic factors like factor V Leiden mutation, and pro-thrombotic platelet glycoprotein GP Ia, and GP IIIa polymorphisms were examined.


RESULTS
Amongst pro-thrombotic platelet glycoprotein polymorphisms moderately pro-thrombotic heterozygous A1/A2, and heterozygous C/T were most prevalent. The least common were strongly pro-thrombotic homozygous A2/A2, and T/T. Analysis of the factor V Leiden mutation revealed statistically significant difference in the presence of allele A, which determines the prothrombotic tendencies in its carrier.


CONCLUSIONS
Our study shows that factor V Leiden mutation, and investigated platelet GP Ia, and GP IIIa polymorphisms frequently coexist. Moreover, presence of factor V Leiden mutation is a risk factor for thrombo-embolic disease in the women in childbirth.
Podciechowski
Lech
L
Klinika Medycyny Matczyno-Płodowej i Ginekologii, Instytutu Centrum Zdrowia Matki Polki w Lodzi. lechpodciech@go2.pl
Nowakowska
Dorota
D
Dabrowska
Katarzyna
K
Bielak
Adam
A
Dziatosz
Krzysztof
K
Krasomski
Grzegorz
G
Wilczyński
Jan
J
D000328:Adult; D005165:Factor V / Q000235:genetics; D005167:Factor VII / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D039421:Integrin alpha2 / Q000235:genetics; D039661:Integrin beta3 / Q000235:genetics; D007743:Labor, Obstetric / Q000097:blood*; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000453:epidemiology / Q000235:genetics*; D020246:Venous Thrombosis / Q000453:epidemiology / Q000235:genetics*
D039421:Integrin alpha2; D039661:Integrin beta3; D005165:Factor V; D005167:Factor VII