title: Three decades of antidepressant, anxiolytic and hypnotic use in a national population birth cohort.
abstract: BACKGROUND
  Psychotropic medication use is common and increasing. Use of such drugs at the individual level over long periods has not been reported.
  
  
  OBJECTIVE
  To describe antidepressant, anxiolytic and hypnotic drug use, and associations between such medication use and common mental disorder, over a 22-year period.
  
  
  METHODS
  Questions about psychotropic medication use and symptoms of common mental disorder were asked of more than 3000 members of the 1946 British birth cohort at multiple time points between ages 31 and 53 years.
  
  
  RESULTS
  Prevalence of any antidepressant, anxiolytic or hypnotic use increased significantly from 1977 (30.6 per 1000) to 1999 (59.1 per 1000) as the cohort aged. Less than 30% with mental disorder used antidepressants, anxiolytics or hypnotics. Previous use of antidepressant, anxiolytic or hypnotic was a strong predictor of future use during an episode of mental disorder (odds ratios 3.0-8.4); this association became weaker over time.
  
  
  CONCLUSIONS
  Pharmacotherapy is infrequently used by individuals with common mental disorder in Britain; this has not changed in the past three decades.
authors.affiliation: Department of Psychiatry, University of Cambridge, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Colman
authors.forename: Michael E J
authors.initials: ME
authors.lastname: Wadsworth
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Croudace
authors.forename: Peter B
authors.initials: PB
authors.lastname: Jones
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D001523:Mental Disorders / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D008875:Middle Aged; D010342:Patient Acceptance of Health Care / Q000523:psychology; D015995:Prevalence; D012720:Severity of Illness Index; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D006993:Hypnotics and Sedatives