Melatonin and roentgen irradiation of the testis.
Melatonin is a free-radical scavenger and antioxidant. Roentgen irradiation of testis (animal model formed of albino rats) was associated with destruction and depletion of the germinal epithelial cells. In roentgen-irradiated, melatonin-pretreated animals, these changes were markedly ameliorated. Thus administration of melatonin before irradiation can protect testis from some of the destructive effects of roentgen irradiation.
Hussein
Mahmoud R
MR
Department of Histopathology, Assir Central Hospital (King Khlid University Teaching Hospitals), Assir, Kingdom of Saudi Arabia. mrh17@swissinfo.org
Abu-Dief
Eman E
EE
Abou El-Ghait
Amal T
AT
Adly
Mohamed A
MA
Abdelraheem
Mohamad H
MH
D000818:Animals; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D011832:Radiation Injuries / Q000473:pathology* / Q000517:prevention & control*; D011836:Radiation Tolerance / Q000187:drug effects*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000293:injuries / Q000473:pathology / Q000528:radiation effects*; D014916:Whole-Body Irradiation / Q000009:adverse effects
D011837:Radiation-Protective Agents; D008550:Melatonin