title: How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations.
abstract: The default mode of brain function hypothesis and the presence of spontaneous intrinsic low-frequency signal fluctuations during rest have recently attracted attention in the neuroscience community. In this study we asked two questions: First, is it possible to attenuate intrinsic activity in the self-referential, default mode of brain function by directing the brains resources to a goal-oriented and attention-demanding task? Second, what effect does a sustained attention-demanding overt task performance have on the two intrinsically active networks in the brain, those being the task-negative, default-mode and the anticorrelated, task-positive network? We used functional magnetic resonance imaging to monitor spontaneous intrinsic activity during rest and sustained performance of a sequential two-back working memory task. We compared intrinsic activity during rest and the two-back task to the signal increases and decreases observed in an epoch-related version of the working memory task. Our results show that spontaneous intrinsic activity in the default-mode network is not extinguished but rather attenuated during performance of the working memory task. Moreover, we show that the intrinsic activity in the task-positive network is reorganized in response to the working memory task. The results presented here complements earlier work that have shown that task-induced signal deactivations in the default-mode regions is modulated by cognitive load to also show that intrinsic, spontaneous signal fluctuations in the default-mode regions persist and reorganize in response to changes in external work load.
authors.affiliation: MR Research Center, Cognitive Neurophysiology, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. Peter.Fransson@ki.se
authors.forename: Peter
authors.initials: P
authors.lastname: Fransson
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008959:Models, Neurological; D010100:Oxygen / Q000097:blood; D025341:Principal Component Analysis; D013057:Spectrum Analysis; D013223:Statistics as Topic
chemical_list: D010100:Oxygen