Resveratrol, a polyphenolic phytoalexin attenuates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rats.
The effects of resveratrol, a polyphenolic phytoalexin present in red wine have been investigated on hyperalgesia and cold allodynia in streptozotocin (STZ) induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin (65mg/kg). After 4-weeks of STZ injection, diabetic rats exhibited a significant thermal hyperalgesia and cold allodynia along with increased plasma glucose and decreased body weights as compared with controls rats. Chronic treatment with resveratrol (10mg/kg orally) from week 4 to week 6 significantly attenuated the cold allodynia and thermal hyperalgesia. The results emphasize the role of oxidative stress in development of hyperalgesia and cold allodynia in diabetic animals and point towards the potential of resveratrol as an adjuvant therapy for the prevention and treatment of diabetic neuropathy.
Sharma
Sameer
S
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
Kulkarni
S K
SK
Chopra
Kanwaljit
K
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D003080:Cold Temperature; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D006358:Hot Temperature; D006930:Hyperalgesia / Q000209:etiology / Q000517:prevention & control*; D007101:Immersion; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D012717:Sesquiterpenes; D013267:Stilbenes / Q000008:administration & dosage / Q000627:therapeutic use*; D013729:Terpenes; D000094162:Phytoalexins
D000975:Antioxidants; D001786:Blood Glucose; D010936:Plant Extracts; D012717:Sesquiterpenes; D013267:Stilbenes; D013729:Terpenes; D000077185:Resveratrol; D000094162:Phytoalexins