title: Cerebral vasoreactivity is influenced by the prandial state among migraineurs.
abstract: OBJECTIVE
  To test if the cerebral vasoreactivity among migraineurs is influenced by the prandial state.
  
  
  METHODS
  Eight patients with migraine without aura were studied (mean age = 23.75 years; range = 19 to 32 years; 6 women). We also studied 8 healthy controls (mean age = 20.63 years; range = 18 to 22 years; 3 women), with no history of migraine. Cerebral vasoreactivity was measured on the right side by the breath holding index (BHI) using an EZ-Dop transcranial Doppler instrument, with a 2-MHz transducer fitted on a headband. Serum glucose levels were measured after a 10-hour fasting period and then 10 minutes after a standardized breakfast.
  
  
  RESULTS
  In both groups, we found a postprandial (PP) glycemia enhancement (P < .02). Migraineurs showed enhanced PP cerebral vasoreactivity when compared to the fasting state (FS) (BHI-PP = 1.46; BHI-FS = 1.16; P= .02). Among controls, we found a trade to enhancement, but without statistic significance (BHI-PP = 1.28; BHI-FS = 1.11; P= .30). Glucose levels were not significantly correlated to cerebral vasoreactivity in any of the groups (P > .05).
  
  
  CONCLUSIONS
  Our findings suggest that migraineurs have a higher reactivity to hypercapnia during the PP period.
authors.affiliation: Universidade Católica de Brasília, Brasilia, Distrito Federal, Brazil.
authors.forename: Rodolfo de S
authors.initials: Rde S
authors.lastname: Coelho
authors.forename: Ciro M
authors.initials: CM
authors.lastname: Gomes
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Teixeira
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005215:Fasting / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D020326:Migraine without Aura / Q000097:blood / Q000503:physiopathology*; D019518:Postprandial Period / Q000502:physiology*
chemical_list: D001786:Blood Glucose