title: Detection and estimation of antimalarial drugs in body fluids--I. Field test for amodiaquine in urine and saliva.
abstract: Simple and specific tests for the detection of antimalarial drugs are required during clinical studies on the sensitivity of Plasmodium falciparum to these drugs. A specific colour test has been developed for amodiaquine which is sensitive enough to permit the visual detection of the drug, following the oral administration of a single 600 mg dose, for up to 10 days in saliva and up to seven weeks in urine. The test is based on the oxidation of amodiaquine to a yellow-coloured derivative using an aqueous solution of potassium persulphate and disodium hydrogen orthophosphate as oxidant. The colour has also been determined spectrophotometrically at 560 nm to achieve a lower detection limit of 0.5 microg amodiaquine in 10 ml biological fluid.
authors.affiliation: Department of Chemistry, University of Ibadan, Ibadan, Nigeria.
authors.forename: O R
authors.initials: OR
authors.lastname: Idowu