Transforming growth factor beta and monocyte chemotactic protein-1 are elevated in cerebrospinal fluid of immunocompromised patients with HIV-1 infection.
Monocyte infiltration of the brain is central to the pathogenesis of HIV-1 encephalitis. The cytokines promoting recruitment of monocytes into the central nervous system during HIV-1 infection are not established. In this study, we evaluated human cerebrospinal fluid from patients with HIV-1 infection for transforming growth factor beta1 (TGFbeta1) and monocyte chemotactic protein-1 (MCP-1) using a quantitative sandwich enzyme-linked immunoassays. Cytokine levels were compared to those from patients with multiple sclerosis and normal controls. In cerebrospinal fluid of patients with HIV-1 infection and CD4<500 cells/mm3, both TGFbeta1 and MCP-1 were significantly elevated compared to those with CD4>500 cells/mm3, multiple sclerosis, and controls.
Johnson
M D
MD
University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, and the Nashville Veterans Administration Medical Center, 37232, USA.
Kim
P
P
Tourtellotte
W
W
Federspiel
C F
CF
D018791:CD4 Lymphocyte Count; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid*; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D012016:Reference Values; D016212:Transforming Growth Factor beta / Q000134:cerebrospinal fluid*
D018932:Chemokine CCL2; D016212:Transforming Growth Factor beta