title: Combination regimen of methylprednisolone, IV immunoglobulin, and plasmapheresis early in the treatment of acute disseminated encephalomyelitis.
abstract: Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease of the central nervous system that is associated with significant morbidity and mortality. Early recognition of the disease is of paramount importance; however, treatment options are limited because only case reports and small series are available in the literature. We report a case of a 42 year-old previously healthy man, whom we treated successfully with a combination regimen of methylprednisolone, IV immunoglobulin, and plasmapheresis early in the course of the disease.
authors.affiliation: Department of Medicine, Saint Vincent Hospital at Worcester Medical Center, Worcester, Massachusetts 01608, USA. rommelperillolu@yahoo.com
authors.forename: Rommel P
authors.initials: RP
authors.lastname: Lu
authors.forename: Gary
authors.initials: G
authors.lastname: Keilson
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004673:Encephalomyelitis, Acute Disseminated / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use*; D010951:Plasma Exchange; D010956:Plasmapheresis; D012141:Respiratory Tract Infections / Q000150:complications; D013997:Time Factors; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D008353:Mannitol; D014640:Vancomycin; D002443:Ceftriaxone; D000212:Acyclovir; D008775:Methylprednisolone