title: [A case of brain nocardiosis successfully treated with minocycline].
abstract: A 60-year-old man with surgically treated nocardia pyothorax was referred to our hospital since he became drowsy. Brain MRI revealed multiple brain abscesses. His cerebrospinal fluid (CSF) showed increase in polymorphonuclear cells and decrease in glucose. Since he was allergic to sulfamethoxazole * trimethoprim, ceftriaxone and then minocycline were given. Minocycline resulted in dramatic improvement of neurological symtoms, MRI findings and CSF cell count. PCR analysis of 16S ribosomal DNA using his resected thoracic wall revealed that nocardia from his tissue was strain IFM0860. Strain IFM0860 nocardia was found to be sensitive to minocycline but not to sulfamethoxazole * trimethoprim and ceftriaxone. Intravenous administration of minocycline was followed by three-year per os administration of minocycline during which he had no recurrence of brain abscess. Thus, brain nocardiosis could be successfully treated with appropriate antibiotics. The lesson from the present case is that identification of the type of nocardia by PCR analysis of 16S ribosomal DNA could help accomplish tailor-made antibiotic therapy.
authors.affiliation: Department of Neurology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Suzuki
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kimura
authors.forename: Akira
authors.initials: A
authors.lastname: Arai
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Maeda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tomiyama
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kannari
authors.forename: Masayuki
authors.initials: M
authors.lastname: Baba
authors.forename: Chieko
authors.initials: C
authors.lastname: Itabashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Wada
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy*; D016724:Empyema, Pleural / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D009617:Nocardia Infections / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline