[Lipodystrophic syndromes: congenital or acquired diseases of adipose tissue].
Lipodystrophic syndromes regroup a heterogeneous group of genetic or acquired diseases. Lipodystrophy, an altered development and/or repartition of body fat, is associated with alterations of lipid and glucose metabolism with insulin resistance. Genetic forms, rare, can be generalized and recessive resulting from mutations in the seipin or AGPAT2 gene. Partial lipodystrophies are dominant and observed in patients mutated in the gene encoding PPAR-gamma or lamin A/C, a gene seen also mutated in patients with syndromes of premature aging. Acquired forms are common and regroup the highly prevalent Metabolic Syndrome, hypercorticism together with lipodystrophy related to antiretroviral treatment of HIV-infected patients.
Capeau
Jacqueline
J
Inserm, U680, université Pierre-et-Marie-Curie, site Saint-Antoine, faculté de médecine, 27, rue Chaligny, 75571 Paris cedex 12, France. capeau@st-antoine.inserm.fr
Vigouroux
Corinne
C
Magré
Jocelyne
J
Lascols
Olivier
O
Caron
Martine
M
Bastard
Jean-Philippe
JP
D000273:Adipose Tissue / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D039682:HIV-Associated Lipodystrophy Syndrome / Q000151:congenital / Q000503:physiopathology*; D006801:Humans; D008060:Lipodystrophy / Q000145:classification / Q000151:congenital / Q000235:genetics / Q000503:physiopathology*; D051379:Mice