title: [Clinical study of deoxyribonucleotidum for adjuvant treatment of pulmonary tuberculosis with hepatic lesion].
abstract: OBJECTIVE
  To evaluate of therapeutic efficacy of deoxyribouncleotidum on pulmonary tuberculosis.
  
  
  METHODS
  Eighty patients with pulmonary tuberculosis sustaining hepatic lesion after treatment with antituberculosis drugs were randomized into therapeutic group and control group. Patients in the control group received regular treatment and those in the therapeutic group had additional deoxyribouncleotidum injection.
  
  
  RESULTS
  ALT, AST, ALP and TBIL levels were significantly higher in the therapeutic group than in the control group 4 weeks after treatment. IgG, IgA, IgM levels, and CD3(+) and CD8(+) lymphocytes were significantly increased in the therapeutic group after treatment (P<0.05).
  
  
  CONCLUSIONS
  deoxyribouncleotidum can improve hepatic function and immunity in patients with pulmonary tuberculosis.
authors.affiliation: Sixth Division, Department of Internal Medicine, Guangzhou Municipal Hospital of Chest Medicine, Guangzhou 510095, China.
authors.forename: Yong-hao
authors.initials: YH
authors.lastname: Chen
authors.forename: Zhi-cheng
authors.initials: ZC
authors.lastname: Chen
authors.forename: Qing-xin
authors.initials: QX
authors.lastname: Chen
authors.forename: Qing-yu
authors.initials: QY
authors.lastname: Lin
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000378:metabolism; D017252:CD3 Complex / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D056486:Chemical and Drug Induced Liver Injury; D003854:Deoxyribonucleotides / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007267:Injections; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D017252:CD3 Complex; D003854:Deoxyribonucleotides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase