title: Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome which can be an inherited congenital disorder or can develop secondary to malignancy, infection, or autoimmune disease. Secondary HLH due to malignancy occurs most commonly with T or NK-cell lymphoid neoplasms. HLH with B-cell malignancies is less common and HLH has rarely been described in association with precursor B-cell acute lymphoblastic leukemia (B-ALL). We report three cases of HLH associated with B-ALL and review 17 cases of ALL-associated HLH previously reported in the literature.
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA.
authors.forename: Maureen M
authors.initials: MM
authors.lastname: O'Brien
authors.forename: Youngna
authors.initials: Y
authors.lastname: Lee-Kim
authors.forename: Tracy I
authors.initials: TI
authors.lastname: George
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: McClain
authors.forename: Clare J
authors.initials: CJ
authors.lastname: Twist
authors.forename: Michael
authors.initials: M
authors.lastname: Jeng
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000276:immunology; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000276:immunology