title: A case of inflammatory pseudotumor in the spleen.
abstract: A case of an inflammatory pseudotumor of the spleen is presented. A 43-year-old woman was hospitalized for a detailed examination due to pancytopenia, which was diagnosed during an examination related to left upper quadrant abdominal pain. Physical examination revealed a 2 to 3 cm splenomegaly. Reticulocyte count was 4% and erythrocyte sedimentation rate was 55 mm/h. No other important findings were noted, except for an evident increase in myeloid series and megakaryocytes (more evident in erythroid series) on bone marrow aspiration and biopsy. Computed tomography (CT) scan revealed splenomegaly and a centrally located hypodense lesion with a 92 X 86 mm axial diameter in the spleen. With a hematologic malignancy prediagnosis, a splenectomy was performed on the patient because of pancytopenia and splenomegaly. An intrasplenic, centrally located, well-limited, capsulated lesion (9.5 x 11 x 10 cm in diameter) was discovered on macroscopic examination of the material. A cellular infiltration area was seen on microscopic examination. The spleen capsule was mildly fibrotically thickened. The lesion that separated from the spleen tissue consisted of diffusely proliferated fusiform fibroblasts, heterogenous inflammatory cells consisting mainly of plasma cells, lymphocytes, sparse neutrophils and vascular elements. No granuloma or multinuclear giant cells were detected. Pancytopenia improved on follow-up. The patient followed up for two years, is now healthy and has no complaints.
authors.affiliation: Department of Internal Medicine, Taksim Education and Research Hospital, and the Department of Internal Medicine, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.
authors.forename: Aslan
authors.initials: A
authors.lastname: Celebi
authors.forename: Seyit Mehmet
authors.initials: SM
authors.lastname: Kayacan
authors.forename: Serkan
authors.initials: S
authors.lastname: Keskin
authors.forename: Ela
authors.initials: E
authors.lastname: Temeloglu
authors.forename: Deniz
authors.initials: D
authors.lastname: Koç
authors.forename: Vildan
authors.initials: V
authors.lastname: Ercan
authors.forename: Deniz
authors.initials: D
authors.lastname: Esin
authors.forename: Ismail
authors.initials: I
authors.lastname: Ekizoglu
authors.forename: Sezai
authors.initials: S
authors.lastname: Vatansever
authors.forename: Mine G
authors.initials: MG
authors.lastname: Gulluoglu
authors.forename: Osman
authors.initials: O
authors.lastname: Erk
mesh_terms: D000328:Adult; D005260:Female; D006104:Granuloma, Plasma Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D013158:Splenic Diseases / Q000175:diagnosis* / Q000473:pathology