Combined immune deficiencies in children.
Combined immune deficiencies are a heterogeneous group of congenital disorders usually attributable to a single gene defect. The hallmark of these disorders is recurrent infections resulting from defects in both T- and B-cell function. This article reviews the basic components of the immune system as well as the clinical presentation, laboratory findings, and treatment for 3 distinct combined immune deficiencies.
Kobrynski
Lisa J
LJ
Emory University, and Emory Children's Center in Atlanta, Georgia 30322, USA. lkobryn@emory.edu
D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000917:Antibody Formation / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D016026:Bone Marrow Transplantation; D002648:Child; D003663:Decision Trees; D004062:DiGeorge Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005440:Fluid Therapy; D005817:Genetic Counseling; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007239:Infections / Q000188:drug therapy / Q000209:etiology; D040582:Inheritance Patterns / Q000235:genetics / Q000276:immunology; D011379:Prognosis; D016511:Severe Combined Immunodeficiency / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D033581:Stem Cell Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
D000900:Anti-Bacterial Agents; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous