Role of C825T polymorphism of GNbeta3 gene in preeclampsia.
OBJECTIVE
The main objective of the study was to understand the role of C825T polymorphism that generates a splice variant in the beta3 subunit of heterotrimeric G-protein in preeclampsia.


RESULTS
We analyzed genomic DNA of 151 women with preeclampsia (72 Caucasians and 79 African-Americans) and 198 women with normal delivery (102 Caucasians and 96 African-Americans) for C825T polymorphism of GNbeta3 gene. The T-allele frequency in Caucasian women with preeclampsia was 0.42 as compared to 0.25 in normal pregnant women (p = 0.0004) and in African-American women with preeclampsia was 0.82 as compared to 0.68 in normal pregnant women (p = 0.0028).


CONCLUSIONS
Results of these experiments show that the allele frequency of C825T polymorphism is significantly different in women with preeclampsia compared with women with normal delivery in Caucasian as well as African-American population.
Tang
Xiangna
X
Department of Pathology, New York Medical College, Valhalla, New York 10595, USA.
Guruju
Mallikarjunarao
M
Rajendran
Geetha P
GP
Isler
Christy M
CM
Martin
James N
JN
Kumar
Ashok
A
D000328:Adult; D001741:Black or African American / Q000235:genetics; D016022:Case-Control Studies; D003596:Cytosine; D005260:Female; D005787:Gene Frequency; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D013941:Thymine; D044465:White People / Q000235:genetics
C454420:G-protein beta3 subunit; D003596:Cytosine; D020962:Heterotrimeric GTP-Binding Proteins; D013941:Thymine