Maternal outcome in HELLP syndrome requiring intensive care management in a Turkish hospital.
OBJECTIVE
Despite the development of tertiary care facilities, intensive care and advanced blood banking techniques, pregnancy-related hypertensive disorders are the main cause of maternal mortality in most countries. Our purpose was to determine maternal outcome in pregnancies complicated by HELLP syndrome (hemolysis, elevated liver enzymes and low platelet count) that required intensive care management.


METHODS
Retrospective study at Department of Obstetrics and Gynecology, and Department of Anesthesiology and Reanimation, Karadeniz Technical University, Trabzon, Turkey.


METHODS
37 patients with HELLP syndrome admitted to the obstetric intensive care unit were analyzed retrospectively from 1992 to 2004.


RESULTS
All patients were hypertensive, with mean Glasgow coma score (GCS) of 11 +/- 3.96. Mean gestational age at delivery was 32 +/- 4.09 weeks. Delivery was vaginally in nine and by cesarean section in 27 patients. General anesthesia was used in 12 and spinal anesthesia in 25 patients. Maternal morbidity included acute renal failure (11%), disseminated intravascular coagulation (5%), acute lung edema (3%), severe ascites (11%), pleural effusion (3%), adult respiratory distress syndrome (11%), abruptio placenta (11%), cerebral edema (8%) and cerebral hemorrhage (40%). All patients required transfusions using blood products. There were 11 maternal deaths (30%).


CONCLUSIONS
Because of high maternal mortality and morbidity found among patients with HELLP syndrome, standard antenatal follow-up protocols should be applied, so as to obtain early diagnosis and improve the speed of transfer to obstetric departments with expertise in this field.
Osmanagaoglu
Mehmet Armagan
MA
Department of Obstetrics and Gynecology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. osmanaga@meds.ktu.edu.tr
Osmanagaoglu
Selen
S
Ulusoy
Hülya
H
Bozkaya
Hasan
H
D000328:Adult; D001803:Blood Transfusion; D003422:Critical Care; D005260:Female; D015600:Glasgow Coma Scale; D017359:HELLP Syndrome / Q000401:mortality* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008428:Maternal Mortality; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology