title: Antibacterial and cytotoxic activity of Brazilian plant extracts--Clusiaceae.
abstract: Twelve extracts obtained from nine plants belonging to six different genera of Clusiaceae were analyzed against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus and Enterococcus faecalis) bacteria using the microdilution broth assay. Tovomita aff. longifolia, T. brasiliensis, Clusia columnaris, Garcinia madruno, Haploclathra paniculata, and Caraipa grandifolia extracts showed significant results against the bacteria. The organic extract obtained from the leaves of T. aff. longifolia showed minimal inhibitory concentration (MIC) = 70 microg/ml and minimal bactericidal concentration (MBC) = 90 microg/ml against E. faecalis and the organic extract made with the stem of C. columnaris showed MIC = 180 microg/ml and MBC = 270 microg/ml against P. aeruginosa. None of the antibacterial extracts showed lethal activity against brine shrimp nauplii. On the other hand, both aqueous and organic extracts obtained from the aerial organs of Vismia guianensis that were cytotoxic to brine shrimp nauplii did not show a significant antibacterial activity in the assay.
authors.affiliation: Laboratório de Extração, Universidade Paulista, São Paulo, SP, 01310-100, Brasil. extractlab@unip.br
authors.forename: Ivana B
authors.initials: IB
authors.lastname: Suffredini
authors.forename: Mateus Lb
authors.initials: ML
authors.lastname: Paciencia
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Nepomuceno
authors.forename: Riad N
authors.initials: RN
authors.lastname: Younes
authors.forename: Antonio D
authors.initials: AD
authors.lastname: Varella
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D001156:Artemia / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry* / Q000145:classification; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts