title: [Application of cell technologies to tissue defect closure in oncology].
abstract: In vivo and in vitro experiments on the application of cell technologies to tissue defect closure were conducted; autologic mesenchymal stem cells on 3-demensional matrices were used. The authors analyze the results of the application of bioengineering tissue equivalents for the closure of soft tissue and upper airway defects after extensive resections performed in 52 oncological patients. Tissue equivalents with stem cells provide engraftment and long-term graft functioning; they also modify wound surface, thus stimulating wound epithelization. In this study the application of tissue equivalents led to wound healing and functional recovery in 87% of patients.
authors.forename: V I
authors.initials: VI
authors.lastname: Chissov
authors.forename: I V
authors.initials: IV
authors.lastname: Reshetov
authors.forename: N S
authors.initials: NS
authors.lastname: Sergeeva
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
authors.forename: S M
authors.initials: SM
authors.lastname: Barinov
authors.forename: V V
authors.initials: VV
authors.lastname: Terskikh
authors.forename: I K
authors.initials: IK
authors.lastname: Sviridova
authors.forename: V S
authors.initials: VS
authors.lastname: Komlev
authors.forename: V A
authors.initials: VA
authors.lastname: Kirsanova
authors.forename: E V
authors.initials: EV
authors.lastname: Batukhtina
authors.forename: O S
authors.initials: OS
authors.lastname: Rogovaia
authors.forename: M M
authors.initials: MM
authors.lastname: Filiushin
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D066298:In Vitro Techniques; D007822:Laryngeal Neoplasms / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing