title: First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America.
abstract: The plasmid-mediated class A carbapenemase KPC-2 was isolated from unrelated Klebsiella pneumoniae isolates in Medellin, Colombia. These KPC enzymes are the first from South America and the second isolation outside of the United States. The expanding geographic spread of KPC carbapenemases underscores the importance of clinical recognition of these enzymes.
authors.affiliation: CIDEIM (International Center for Medical Research and Training), Cali, Colombia.
authors.forename: Maria Virginia
authors.initials: MV
authors.lastname: Villegas
authors.forename: Karen
authors.initials: K
authors.lastname: Lolans
authors.forename: Adriana
authors.initials: A
authors.lastname: Correa
authors.forename: Carlos Jose
authors.initials: CJ
authors.lastname: Suarez
authors.forename: Jaime A
authors.initials: JA
authors.lastname: Lopez
authors.forename: Marta
authors.initials: M
authors.lastname: Vallejo
authors.forename: John P
authors.initials: JP
authors.lastname: Quinn
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D015780:Carbapenems / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D007526:Isoelectric Point; D007710:Klebsiella Infections / Q000453:epidemiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010957:Plasmids / Q000235:genetics*; D013020:South America / Q000453:epidemiology; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; C063912:carbapenemase