title: Poly-L-lysine-induced morphology changes in mixed anionic/zwitterionic and neat zwitterionic-supported phospholipid bilayers.
abstract: Poly-L-lysine-induced morphological changes in liquid phase supported bilayers consisting of mixed anionic/zwitterionic and neat zwitterionic headgroup phospholipids were studied with atomic force microscopy and epifluorescence microscopy. Results obtained from these studies indicate that poly-L-lysine can induce domains, defects, and aggregate structures on both mixed bilayers and strictly zwitterionic bilayers. The structures formed on liquid phase supported bilayers were observed to be immobile from a timescale of 50 ms to several minutes. We propose that poly-L-lysine of sufficient length interacts with the mica substrate and phospholipids to create the stationary structures noted.
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: Tighe A
authors.initials: TA
authors.lastname: Spurlin
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Gewirth
mesh_terms: D005782:Gels; D007477:Ions; D008051:Lipid Bilayers / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D010743:Phospholipids / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry*
chemical_list: D005782:Gels; D007477:Ions; D008051:Lipid Bilayers; D010743:Phospholipids; D011107:Polylysine