title: Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study.
abstract: Interactions between prevalent late-life medical conditions and expansion of the cerebral ventricles are not well understood. Thirty elderly subjects received three magnetic resonance (MR) scans each, in 1997-1999, 2002-2004, and 2003-2005. A linear expansion model of MR-measured lateral ventricle volume was estimated for each subject by fitting a line to a plot of their 1997-1999 and 2002-2004 volumes as a function of time. Acceleration in ventricular expansion was defined as the deviation between the 2003-2005 volumes measured from MR and the 2003-2005 volumes predicted by the linear expansion model. Ventricular acceleration was analyzed in a multivariate model with age, race, history of heart disease, diabetes, and hypertension as fixed effects. Ventricular acceleration was significantly higher in non-whites, diabetics, and those without heart disease (p<0.05). Ventricular acceleration was higher in subjects with a history of hypertension, but the difference was not statistically significant (p=0.08). Acceleration of ventricular expansion in the elderly may be related to demographic and cardiovascular factors.
authors.affiliation: Neurology Department, University of California, Center For Neuroscience, 1544 Newton Court, Davis, CA 95616, United States. ocarmichael@ucdavis.edu <ocarmichael@ucdavis.edu>
authors.forename: Owen T
authors.initials: OT
authors.lastname: Carmichael
authors.forename: L H
authors.initials: LH
authors.lastname: Kuller
authors.forename: O L
authors.initials: OL
authors.lastname: Lopez
authors.forename: P M
authors.initials: PM
authors.lastname: Thompson
authors.forename: R A
authors.initials: RA
authors.lastname: Dutton
authors.forename: A
authors.initials: A
authors.lastname: Lu
authors.forename: S E
authors.initials: SE
authors.lastname: Lee
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Aizenstein
authors.forename: C C
authors.initials: CC
authors.lastname: Meltzer
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: A W
authors.initials: AW
authors.lastname: Toga
authors.forename: J T
authors.initials: JT
authors.lastname: Becker
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002318:Cardiovascular Diseases / Q000473:pathology / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D012016:Reference Values; D012189:Retrospective Studies; D012737:Sex Factors; D013997:Time Factors