Coenzyme Q10 supplementation reduces corticosteroids dosage in patients with bronchial asthma.
Bronchial asthma is a chronic inflammatory disease of respiratory system, with disturbances in the dynamic balance of oxidant-antioxidant capacity of the lungs. Long-term administration of corticosteroids has been shown to result in mitochondrial dysfunction and oxidative damage of mitochondrial and nuclear DNAs. We previously documented decreased coenzyme Q(10) (CoQ(10)) and alpha-tocopherol concentrations in plasma and blood in corticosteroid-dependent bronchial asthma patients. In the present study we demonstrate that CoQ(10) supplementation reduces the dosage of corticosteroids in these patients.


METHODS
This was an open, cross-over, randomized clinical study with 41 bronchial asthma patients (13 males, 28 females), ages 25-50 years. All patients suffered from persistent mild to moderate asthma. The patients were divided into two groups, one group receiving standard antiasthmatic therapy and clinically stabilized, and the second group receiving, in addition, antioxidants consisting of CoQ(10) as Q-Gel (120 mg) + 400 mg alpha-tocopherol + 250 mg vitamin C a day. The groups were crossed over at 16 weeks for a total duration of 32 weeks.


CONCLUSIONS
Data show that patients with corticosteroid-dependent bronchial asthma have low plasma CoQ(10) concentrations that may contribute to their antioxidant imbalance and oxidative stress. A reduction in the dosage of corticosteroids required by the patients following antioxidant supplementation was observed, indicating lower incidence of potential adverse effects of the drugs, decreased oxidative stress. This study also demonstrates the significant uptake of CoQ(10) by lung tissue in a rat model using hydrosoluble CoQ(10) (Q-Gel).
Gvozdjáková
Anna
A
Comenius University, Medical Faculty, Pharmacobiochemical Laboratory, Bratislava, Slovakia. physicus@netax.sk
Kucharská
Jarmila
J
Bartkovjaková
Mária
M
Gazdíková
Katarína
K
Gazdík
Frantis Ek
FE
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D003067:Coenzymes; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10; D024502:alpha-Tocopherol; D001205:Ascorbic Acid