title: Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models.
abstract: Extracts of Ginkgo biloba (EGB) are a complex product prepared from green leaves of the Ginkgo biloba tree. In the present study, the antidepressant effect of EGB was examined using two behavioral models, the forced swimming test (FST) in rats and tail suspension test (TST) in mice. EGB significantly reduced immobility time in the FST at a dosage of 10 and 50 mg/kg body weight after repeated oral treatment for 14 d, although no change of motor dysfunction was observed with the same dosage in the open field test. These results indicate that EGB might possess an antidepressant activity. In addition, EGB markedly shortened immobility time in the TST after acute inter-peritoneal treatment at a dosage of 50 and 100 mg/kg body weight. The present study clearly demonstrated that EGB exerts an antidepressant effect in these two behavioral models.
authors.affiliation: Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakakibara
authors.forename: Kaori
authors.initials: K
authors.lastname: Ishida
authors.forename: Oliver
authors.initials: O
authors.lastname: Grundmann
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Nakajima
authors.forename: Shujiro
authors.initials: S
authors.lastname: Seo
authors.forename: Veronika
authors.initials: V
authors.lastname: Butterweck
authors.forename: Yuko
authors.initials: Y
authors.lastname: Minami
authors.forename: Satomi
authors.initials: S
authors.lastname: Saito
authors.forename: Yoshichika
authors.initials: Y
authors.lastname: Kawai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakaya
authors.forename: Junji
authors.initials: J
authors.lastname: Terao
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D020441:Ginkgo biloba / Q000737:chemistry*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts