The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women.
BACKGROUND
Because serum paraoxonase activity is influenced by the -108C/T polymorphism in the PON1 gene, we studied its involvement in the decreased paraoxonase activity recently described in the polycystic ovary syndrome (PCOS).


METHODS
Paraoxonase activity, PON1-108C/T genotypes and clinical, hormonal and biochemical variables were evaluated in a case-control study involving 139 consecutive PCOS patients and 85 healthy controls matched for BMI and prevalence of smoking.


RESULTS
Women homozygous for -108T presented with reduced serum paraoxonase activity compared with carriers of C alleles (P < 0.001), both in PCOS patients and in controls. Although homozygosity for T alleles was more prevalent in PCOS patients than in controls (P = 0.003), serum paraoxonase activity was not significantly different in the PCOS and control groups. In a stepwise multivariate linear regression model, homozygosity for PON1-108T alleles was the only significant predictor of the logarithm of serum paraoxonase activity (beta = -0.328, t = -4.176, P < 0.001).


CONCLUSIONS
In premenopausal women from the Spanish population, the PON1-108C/T polymorphism, and not PCOS, is an important determinant of serum paraoxonase activity.
San Millán
José L
JL
Department of Molecular Genetics, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Alvarez-Blasco
Francisco
F
Luque-Ramírez
Manuel
M
Botella-Carretero
José I
JI
Escobar-Morreale
Héctor F
HF
D043303:Aryldialkylphosphatase / Q000097:blood* / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011110:Polymorphism, Genetic; D017697:Premenopause / Q000235:genetics*
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human