Therapeutic potential of selectin antagonists in psoriasis.
Psoriasis is a systemic chronic inflammatory disorder. One of the major characteristics is an excess of infiltration of inflammatory cells, mainly lymphocytes, into the skin. Because the adhesion family of selectins is suggested to play a relevant role in this process, selectins have emerged as an interesting target for drug discovery and development in psoriasis. Different strategies targeting selectins have been described. This review discusses these approaches and summarises the current development of selectin antagonists for the treatment of psoriasis. An expert opinion will give the authors' personal opinion about selectin antagonism in psoriasis and which approach might be preferable.
Bock
Daniel
D
Revotar Biopharmaceuticals AG, Neuendorfstrasse 24a, 16761 Hennigsdorf, Germany. d.bock@revotar-ag.de
Philipp
Sandra
S
Wolff
Gerhard
G
D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D003879:Dermatologic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000069462:Dimethyl Fumarate; D005650:Fumarates / Q000494:pharmacology / Q000627:therapeutic use; D005786:Gene Expression Regulation / Q000187:drug effects; D006023:Glycoproteins / Q000378:metabolism*; D006028:Glycosphingolipids / Q000494:pharmacology / Q000627:therapeutic use; D006031:Glycosylation; D006801:Humans; D036904:Leukocyte Rolling; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D008024:Ligands; D023421:Models, Animal; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D061988:Proteasome Inhibitors; D011499:Protein Processing, Post-Translational / Q000187:drug effects*; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic; D019087:Selectins / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
D003879:Dermatologic Agents; D005650:Fumarates; D006023:Glycoproteins; D006028:Glycosphingolipids; D008024:Ligands; C411422:PS519; D011480:Protease Inhibitors; D061988:Proteasome Inhibitors; D019087:Selectins; C104429:GSC 150; D046988:Proteasome Endopeptidase Complex; D000069462:Dimethyl Fumarate; D000111:Acetylcysteine