title: [Expression and significance of interleukin-17 and its receptor in nasal polyps].
abstract: OBJECTIVE
  To detect the expression and distribution of interleukin-17 and interleukin 17 receptor (IL-17R) in nasal polyps and to probe into their significance in the pathology of nasal polyps.
  
  
  METHODS
  The methods of immunohistochemical staining and western blot were used to detect IL-17 and IL-17R in nasal polyps and controls.
  
  
  RESULTS
  In nasal polyp tissues, IL-17 expressed mainly in cytoplasm of plasm cell, less in prickle-cell layer of the epithelium and the acinus of the serous gland. In turbinates, IL-17 also expressed in the cytoplasm of the plasm cell, the prickle-cell layer of the epithelium and the acinus of the serous gland. The expression of IL-17 between nasal polyps and turbinates differed significantly (t = 2.237, 2.176, 2.246, P < 0.05, respectively). Both IL-17 and IL-17R displayed specific bands in nasal polyps and turbinates, but the bands of IL-17 and IL-17R in nasal polyps were stronger than those in turbinates.
  
  
  CONCLUSIONS
  IL-17 may have an important role in the occurrence of nasal polyps by specific combination with IL-17R and over-expression in nasal polyps.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Friendship Hospital, Jilin University, Changchun.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D053722:Receptors, Interleukin-17 / Q000378:metabolism*
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17