title: Combined cardiovascular risk factors and outcome: NIPPON DATA80, 1980-1994.
abstract: BACKGROUND
  To examine the prognostic significance of the high-risk group with combined cardiovascular risk factors in the Japanese, we analyzed the relationship between the high-risk group with combined risks and coronary heart disease (CHD) and stroke mortality using the NIPPON DATA80 database.
  
  
  RESULTS
  At baseline in 1980, those of age>or=30 years were randomly selected and 4,144 men and 5,318 women without CHD and/or stroke at baseline were followed for 14 years. The cutoff values for risk components obtained heuristically by Cox analysis were hypertension (systolic>or=130, or diastolic>or=85 mmHg, or on antihypertensive drugs), hypercholesterolemia (total cholesterol>or=200 mg/dl), hyperglycemia (>or=130 mg/dl, or self-reported diabetes) and obesity (body mass index>or=27 kg/m2). Subjects were divided into 3 groups (0, 1-2 and 3-4 risks). Compared with those men in the risk 0 group, the hazard ratios in men in the risk 3-4 for CHD mortality was 8.04 (95% confidence interval: 1.03-62.6), and the stroke mortality was 5.06 (1.53-16.7). In women, no statistically significant difference was found due to a lesser number of events.
  
  
  CONCLUSIONS
  The high-risk group with combined risk factors is important risk for Japanese men.
authors.affiliation: Cardiovascular Epidemiology, Kyoto Women's University, Japan. nakamury@kyoto-wu.ac.jp
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takako
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Tomonori
authors.initials: T
authors.lastname: Okamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Takehito
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kita
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Saitoh
authors.forename: Akira
authors.initials: A
authors.lastname: Okayama
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006943:Hyperglycemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D011379:Prognosis; D016016:Proportional Hazards Models; D012016:Reference Values; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality*