Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker.
Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.
Bedwell
Jeffrey S
JS
Psychology Department, University of Central Florida, Orlando, 32816, USA. jbedwell@mail.ucf.edu
Miller
L Stephen
LS
Brown
James M
JM
Yanasak
Nathan E
NE
D000328:Adult; D000368:Aged; D015415:Biomarkers; D003118:Color Perception / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010775:Photic Stimulation / Q000379:methods; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014795:Visual Pathways / Q000098:blood supply*
D015415:Biomarkers