A case of malignant pheochromocytoma with early intense uptake and immediate rapid washout of 99mTc-tetrofosmin characterizing the overexpression of anti-apoptotic Bcl-2.
Defective apoptotic program due to the overexpression of the anti-apoptotic Bcl-2 protein of the outer mitochondrial membrane may be a cause of the poor response of malignant pheochromocytoma to 131I-MIBG therapy. We report a case of malignant pheochromocytoma which showed early intense uptake and immediate rapid washout of 99mTc-tetrofosmin characterizing the overexpression of anti-apoptotic Bcl-2 and which was refractory to 131I-MIBG therapy.
Wakasugi
Shigetoshi
S
Department of Nuclear Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan. wakasugi-si@mc.pref.osaka.jp
Kinouchi
Toshiaki
T
Taniguchi
Haruo
H
Yokoyama
Kunihiko
K
Fukuchi
Kazuki
K
Noguchi
Atushi
A
Takeshita
Masanori
M
Hashizume
Terumi
T
D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008657:Metabolic Clearance Rate; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010673:Pheochromocytoma / Q000000981:diagnostic imaging* / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
D051017:Apoptosis Regulatory Proteins; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019253:Proto-Oncogene Proteins c-bcl-2; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin