title: An igf-I gene polymorphism modifies the risk of diabetic retinopathy.
abstract: The role of IGF-I in the pathogenesis of diabetic retinopathy is unclear. We studied, prospectively, the relationship between an IGF-I gene polymorphism, retinal vessel diameters, and incident diabetic retinopathy in subjects with impaired glucose tolerance (IGT) or type 2 diabetes. In all 5,505 participants of the population-based Rotterdam Study (775 with IGT, 394 with type 2 diabetes, and 4,336 control subjects), fundus color transparencies were taken at baseline (between 1990 and 1993) and at follow-up (from 1997 to 1999). The wild-type genotype (i.e., carriers of the 192- or 194-bp alleles) was present in 72.7% of the participants, while 27.3% were variant carriers. Variant carriers with IGT or type 2 diabetes appeared to have larger retinal arteriolar and venular diameters at baseline than individuals with the wild-type genotype, but these differences did not reach statistical significance. This trend was especially observed in subjects who developed retinopathy at follow-up. In variant carriers with IGT/diabetes, an increase (odds ratio 1.8 [95% CI 1.0-3.2]; P = 0.04) in the risk of retinopathy was observed compared with participants with the wild-type genotype. In conclusion, our findings suggest that this IGF-I gene polymorphism is associated with an increased risk of diabetic retinopathy.
authors.affiliation: Department of Internal Medicine, Erasmus Medical Center, Room D-436, Dr. Molewaterplein 40, 3015 GD, Rotterdam, Netherlands.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Rietveld
authors.forename: M Kamran
authors.initials: MK
authors.lastname: Ikram
authors.forename: Johannes R
authors.initials: JR
authors.lastname: Vingerling
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Huibert A P
authors.initials: HA
authors.lastname: Pols
authors.forename: Steven W J
authors.initials: SW
authors.lastname: Lamberts
authors.forename: Paulus T V M
authors.initials: PT
authors.lastname: de Jong
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Joop A M J L
authors.initials: JA
authors.lastname: Janssen
mesh_terms: D000368:Aged; D001160:Arterioles / Q000473:pathology; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018149:Glucose Intolerance / Q000235:genetics; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011446:Prospective Studies; D012171:Retinal Vessels / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D014699:Venules / Q000473:pathology
chemical_list: D007334:Insulin-Like Growth Factor I