First development of a polyurethane keratoprosthesis and its Australian connection: an unbeknown episode in the history of artificial cornea.
This paper is aimed at establishing a particular chronological priority issue in the convoluted history of artificial cornea. According to existing records, the first keratoprosthesis made from polyurethane was developed by Caldwell and Jacob-Labarre in the late 1980s. This paper demonstrates that in fact the first polyurethane keratoprosthesis was proposed and designed in 1985 by Lawrence Hirst, an Australian ophthalmologist then working in St Louis, USA. The first prototype was manufactured in January 1986 by Thermedics Inc according to Dr Hirst's instructions from Tecoflex, a transparent polyurethane developed by the same company. This keratoprosthesis, which also had a porous skirt, was inserted intralamellarly in a monkey cornea and followed up clinically for about 3 months. There were no significant postoperative complications, and the histology of the explant indicated proper biointegration of the prosthetic skirt within the host stromal tissue. Because of a delay in the manufacture of further prototypes and to Dr Hirst's decision to return to Australia, the project was eventually abandoned. As no report was published on this development, the present paper is entirely based on original documents held in Dr Hirst's archives.
Chirila
Traian V
TV
Queensland Eye Institute, South Brisbane, Autralia. traian.chirila@pbf.org.au
D001187:Artificial Organs / Q000266:history*; D001315:Australia; D003315:Cornea; D049673:History, 20th Century; D006801:Humans; D009885:Ophthalmology / Q000266:history*; D011140:Polyurethanes / Q000266:history*; D014481:United States
D011140:Polyurethanes