title: The impact of the use of COL-1492, a nonoxynol-9 vaginal gel, on the presence of cervical human papillomavirus in female sex workers.
abstract: This study investigated the effectiveness of a nonoxynol-9 (52.5mg, 3.5%), vaginal gel (Advantage S), in the prevention of human papillomavirus (HPV) infection in female sex workers. We showed by HPV DNA determination in cervico-vaginal rinses a significant increase in multiple (>1) HPV infection in HIV-1 seropositive women compared with HIV-1 seronegative women (OR 4.0, 95% CI 1.3-11.9). We also demonstrated a significant increase in multiple HPV infections in HIV-1 seronegative women using nonoxynol-9 compared with HIV-1 seronegative women using placebo (OR 3.5 95% CI 1.0-11.8). We conclude that the use of nonoxynol-9 did not prevent genital HPV infection and could increase the virus' ability to infect or persist.
authors.affiliation: Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa.
authors.forename: Dianne
authors.initials: D
authors.lastname: Marais
authors.forename: Henri
authors.initials: H
authors.lastname: Carrara
authors.forename: Patti
authors.initials: P
authors.lastname: Kay
authors.forename: Gita
authors.initials: G
authors.lastname: Ramjee
authors.forename: Bruce
authors.initials: B
authors.lastname: Allan
authors.forename: Anna-Lise
authors.initials: AL
authors.lastname: Williamson
mesh_terms: D000282:Administration, Intravaginal; D002584:Cervix Uteri / Q000821:virology; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006679:HIV Seropositivity / Q000150:complications / Q000453:epidemiology; D015497:HIV-1; D006801:Humans; D017137:Nonoxynol / Q000008:administration & dosage*; D027383:Papillomaviridae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000517:prevention & control; D011477:Sex Work; D013019:South Africa / Q000453:epidemiology; D013089:Spermatocidal Agents / Q000008:administration & dosage*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000517:prevention & control; D014622:Vaginal Creams, Foams, and Jellies / Q000008:administration & dosage
chemical_list: D004279:DNA, Viral; D013089:Spermatocidal Agents; D014622:Vaginal Creams, Foams, and Jellies; D017137:Nonoxynol