[Screening of new derivatives of arylheteroalkanecarboxylic acid on the immune system].
The screening of 13 original compounds from the group of derivatives of arylheteroalkanecarboxylic acid on immunity were performed. The compounds exhibit strong myelostimulating/myelosuppressive property, increased or decreased influence on the: PFC (IgM and IgG), DTH at the sheep erythrocytes in CBF1 in vivo. In contrast, in vitro the compounds had no effect or inhibited the spontaneous, ConA or PWM induced proliferation of the splenocytes from normal mice. The problems of the universal methods of the screening of immunoactive properties of compounds are discussed.
Kolesnikova
O P
OP
Kudaeva
O T
OT
Sukhenko
T G
TG
Lykov
A P
AP
Gaĭdul'
K V
KV
Limonov
V L
VL
Mirskova
A N
AN
Lavskovskaia
G G
GG
Voronkov
M G
MG
Kozlov
V A
VA
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D002264:Carboxylic Acids / Q000276:immunology / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D051379:Mice; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000276:immunology
D002264:Carboxylic Acids; D007074:Immunoglobulin G; D007075:Immunoglobulin M