[Markers of inflammation--monocyte chemoattractant protein-1 (MCP-1) and C-reactive protein--in blood of patients with unstable angina pectoris and stable effort angina].
OBJECTIVE
To estimate concentrations of C-reactive protein (CRP) and MCP-1 in blood plasma of patients with unstable angina (UA) and stable effort angina (SEA).


METHODS
Multiprojection coronaroangiography was performed in 12 patients with UA and 11 patients with SEA. Hemodynamically significant stenosis (50% and more) at least in one major coronary artery was confirmed in all the patients. CRP and MCP-1 were measured with latex agglutination and enzyme immunoassay (Biosource kits), respectively.


RESULTS
UA patients had significantly higher plasma levels of MCP-1 and CRP than those with SEA (107.25 +/- 16.19 vs. 63.0 +/- 16.16 pg/ml and 1.99 +/- 1.64 vs 0.44 +/- 0.28 mcg/ml, respectively).


CONCLUSIONS
Estimation of MCP-1, as a marker of vascular wall inflammation, can be used, in line with other indices, for verification of UA.
Provatoriv
S I
SI
Aref'eva
T I
TI
Kukhtina
N B
NB
Liukova
T K
TK
Aref'eva
A M
AM
Krasnikova
T L
TL
D000208:Acute Disease; D000787:Angina Pectoris / Q000378:metabolism; D000789:Angina, Unstable / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000378:metabolism*; D003327:Coronary Disease / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D002097:C-Reactive Protein