title: Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat.
abstract: Effects of early-life trauma on adult behavioral responses, corticosterone (CORT) concentration, and levels of nerve growth factor (NGF), brain-derived neutrophic factor (BDNF), and neurotrophin-3 (NT-3) in hippocampus and frontal cortex were investigated. Traumatized animals showed an increase in rearing in both the elevated plus maze and open field after adult restress, higher basal levels of CORT, lower levels of BDNF in dorsal hippocampus, and lower levels of NT-3 in dorsal and ventral hippocampus. Trauma-related behavioral hyperarousal and altered hypothalamic-pituitary-adrenal (HPA) axis activity may be mediated by decreases in hippocampal neurotrophin expression.
authors.affiliation: MRC Unit for Anxiety and Stress Related Disorders, Department of Medical Physiology, University of Stellenbosch, Tygerberg 7505, South Africa. jduys@sun.ac.za
authors.forename: Joachim D K
authors.initials: JD
authors.lastname: Uys
authors.forename: Lelanie
authors.initials: L
authors.lastname: Marais
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Faure
authors.forename: Desiree
authors.initials: D
authors.lastname: Prevoo
authors.forename: Pieter
authors.initials: P
authors.lastname: Swart
authors.forename: Abdul H
authors.initials: AH
authors.lastname: Mohammed
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Stein
authors.forename: Willie M U
authors.initials: WM
authors.lastname: Daniels
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001143:Arousal / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology*; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis; D006624:Hippocampus / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D020933:Neurotrophin 3 / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014947:Wounds and Injuries / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020933:Neurotrophin 3