Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma.
We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.
Carpentier
C
C
INSERM U711, Biologie des Interactions Neurones and Glie, Université Pierre et Marie Curie, France.
Laigle-Donadey
F
F
Marie
Y
Y
Auger
N
N
Benouaich-Amiel
A
A
Lejeune
J
J
Kaloshi
G
G
Delattre
J-Y
JY
Thillet
J
J
Sanson
M
M
D000328:Adult; D000368:Aged; D000483:Alleles; D016009:Chi-Square Distribution; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011446:Prospective Studies; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012307:Risk Factors; D016329:Sp1 Transcription Factor / Q000378:metabolism*; D016019:Survival Analysis
D012333:RNA, Messenger; D016329:Sp1 Transcription Factor; D066246:ErbB Receptors