The rate of NSAID-induced endoscopic ulcers increases linearly but not exponentially with age: a pooled analysis of 12 randomised trials.
The risk of major ulcer complications on treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is known to increase exponentially with age. However, in a pooled analysis of 12 trial arms, the incidence of endoscopic ulcers on treatment with NSAID was found to increase with age in a roughly linear fashion. Thus, it is concluded that increasing age is associated with both more frequent and more serious NSAID gastropathy.
Boers
Maarten
M
Department of Clinical Epidemiology and Biostatistics, VU University Medical Center 9B-118, PO Box 7507, 1007 MB Amsterdam, The Netherlands. keb.info@vumc.nl
Tangelder
Marco J D
MJ
van Ingen
Hein
H
Fort
John G
JG
Goldstein
Jay L
JL
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000453:epidemiology; D004384:Duodenoscopy; D005260:Female; D005773:Gastroscopy; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal