title: Systemic inflammatory response, prostate-specific antigen and survival in patients with metastatic prostate cancer.
abstract: BACKGROUND
  It is increasingly recognised that, in cancer patients, disease progression is dependent on a complex interaction of the tumour and the host inflammatory response and that the systemic inflammatory response, as evidenced by an elevated C-reactive protein (CRP) concentration, may be a useful prognostic factor.
  
  
  METHODS
  The prognostic value of CRP compared with prostate-specific antigen (PSA) was examined in 62 patients with metastatic prostate cancer receiving androgen-deprivation therapy.
  
  
  RESULTS
  In all, 41 (66%) of patients died, 38 (61%) of their disease. On univariate survival analysis, PSA (p < 0.05) and CRP (p < 0.05) were significant predictors of cancer-specific survival. On multivariate analysis, both PSA (HR 1.96, 95% CI 1.00-3.83, p = 0.049) and CR (HR 1.97, 95% CI 0.99-3.92, p = 0.052) were independent predictors of cancer-specific survival. PSA concentrations were significantly correlated with those of CRP (r(s) = 0.46, p < 0.001).
  
  
  CONCLUSIONS
  The results of the present study suggest that, in patients with metastatic prostate cancer, the presence of an elevated CRP concentration predicts poor outcome, independent of PSA.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, UK.
authors.forename: Peter A
authors.initials: PA
authors.lastname: McArdle
authors.forename: Khurram
authors.initials: K
authors.lastname: Mir
authors.forename: A S K
authors.initials: AS
authors.lastname: Almushatat
authors.forename: A Michael
authors.initials: AM
authors.lastname: Wallace
authors.forename: Mark A
authors.initials: MA
authors.lastname: Underwood
authors.forename: Donald C
authors.initials: DC
authors.lastname: McMillan
mesh_terms: D000368:Aged; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D008297:Male; D009362:Neoplasm Metastasis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000150:complications / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate
chemical_list: D017430:Prostate-Specific Antigen