Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa.
The methanolic extract from the dried stems of Cistanche tubulosa (Schrenk) R. Wight was found to show an inhibitory effect on contractions induced by noradrenaline in isolated rat aortic strips. From the extract, new phenylethanoid oligoglycoside constituents, kankanosides F and G, and an acylated oligosugar, kankanose, were isolated together with 14 known compounds. The structures of these new compounds were determined on the basis of their chemical and physicochemical evidence. In addition, principal constituents, kankanoside F, kankanose, echinacoside, acteoside, and cistanoside F, showed vasorelaxant activity, and several structural requirements for the activity were clarified.
Yoshikawa
Masayuki
M
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. shoyaku@mb.kyoto-phu.ac.jp
Matsuda
Hisashi
H
Morikawa
Toshio
T
Xie
Haihui
H
Nakamura
Seikou
S
Muraoka
Osamu
O
D000215:Acylation; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D031671:Cistanche / Q000737:chemistry*; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D000432:Methanol; D015394:Molecular Structure; D009638:Norepinephrine / Q000494:pharmacology; D009844:Oligosaccharides / Q000737:chemistry* / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014664:Vasodilation / Q000187:drug effects*
D009844:Oligosaccharides; D010636:Phenols; D010936:Plant Extracts; D011188:Potassium; D009638:Norepinephrine; D000432:Methanol