title: Mandelamide-zinc-catalyzed enantioselective alkyne addition to heteroaromatic aldehydes.
abstract: The (S,S)-mandelamide III catalyzes the additions of both aryl- and alkylalkynylzinc reagents to heteroaromatic aldehydes with good yields and enantioselectivities up to 92%. This catalyst is easily prepared in a one-step procedure, and both enantiomers are available. Unlike most other described methods, using this catalyst does not require the addition of Ti(O(i)Pr)4.
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr. Moliner, 50, E-46100-Burjassot (València), Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Blay
authors.forename: Isabel
authors.initials: I
authors.lastname: Fernandez
authors.forename: Alícia
authors.initials: A
authors.lastname: Marco-Aleixandre
authors.forename: José R
authors.initials: JR
authors.lastname: Pedro