title: Modification of the biopolymer castor oil with free isocyanate groups to be applied as bioadhesive.
abstract: Surgical adhesives have been used for several applications, including haemostasis, sealing air leakages and tissue adhesion. The aim of this work was to develop a biodegradable urethane-based bioadhesive containing free isocyanate groups. This material presents the advantage of being biodegradable, biocompatible and having the capacity of reacting with amino groups present in the biological molecules. A urethane based on castor oil (CO) was synthesized by reaction of the molecule with isophorone diisocyanate (IPD). The characterization of the material was accomplished by different techniques: ATR-FT-IR (attenuated transmittance reflection-Fourier transform infrared), swelling capacity determination, evaluation of the moisture curing kinetics, reaction with aminated substrates and determination of surface energy by contact angle measurement. The study of the urethane thermal properties was performed by DMTA (dynamical mechanical thermal analysis) and TGA (thermogravimetric analysis). The haemocompatibility of the urethane was also evaluated by thrombosis and haemolysis tests.
authors.affiliation: Departamento de Engenharia Química, Universidade de Coimbra, Polo II, Pinhal de Marrocos, 3030-290 Coimbra, Portugal. paula_calvinho@yahoo.com
authors.forename: P
authors.initials: P
authors.lastname: Ferreira
authors.forename: R
authors.initials: R
authors.lastname: Pereira
authors.forename: J F J
authors.initials: JF
authors.lastname: Coelho
authors.forename: António F M
authors.initials: AF
authors.lastname: Silva
authors.forename: M H
authors.initials: MH
authors.lastname: Gil
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D002368:Castor Oil / Q000737:chemistry*; D006461:Hemolysis; D006801:Humans; D017953:Isocyanates / Q000737:chemistry*; D008422:Materials Testing; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014014:Tissue Adhesives / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001704:Biopolymers; D017953:Isocyanates; D011140:Polyurethanes; D014014:Tissue Adhesives; C015301:isophorone diisocyanate; D002368:Castor Oil