title: Analysis of epistasis for diabetic nephropathy among type 2 diabetic patients.
abstract: Diabetic nephropathy (DN) is one of the most serious complications of diabetes, accounting for the majority of patients with end-stage renal disease. The molecular pathogenesis of DN involves multiple pathways in a complex, partially resolved manner. The paper presents an exploratory epistatic study for DN. Association analysis were performed on 231 SNP loci in a cohort of 264 type 2 diabetes patients, followed by the epistasis analysis using the multifactor dimensionality reduction and the genetic algorithm with Boolean algebra. A two-locus epistatic effect of EGFR and RXRG was identified, with a cross-validation consistency of 91.7%.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.
authors.forename: Chang-Hsun
authors.initials: CH
authors.lastname: Hsieh
authors.forename: Kung-Hao
authors.initials: KH
authors.lastname: Liang
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Hung
authors.forename: Li-Chin
authors.initials: LC
authors.lastname: Huang
authors.forename: Dee
authors.initials: D
authors.lastname: Pei
authors.forename: Ya-Tang
authors.initials: YT
authors.lastname: Liao
authors.forename: Shi-Wen
authors.initials: SW
authors.lastname: Kuo
authors.forename: Monica Shian-Jy
authors.initials: MS
authors.lastname: Bey
authors.forename: Jui-Lin
authors.initials: JL
authors.lastname: Chen
authors.forename: Ellson Y
authors.initials: EY
authors.lastname: Chen
mesh_terms: D000368:Aged; D000465:Algorithms; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000209:etiology / Q000235:genetics*; D004843:Epistasis, Genetic; D005260:Female; D018773:Genes, erbB-1; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D047491:Retinoid X Receptor gamma / Q000235:genetics; D013624:Taiwan
chemical_list: D047491:Retinoid X Receptor gamma