title: Efficacy of voriconazole in experimental Cryptococcus neoformans infection.
abstract: Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.
authors.affiliation: Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Mavrogiorgos
authors.forename: Oscar
authors.initials: O
authors.lastname: Zaragoza
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Nosanchuk
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000188:drug therapy*; D003455:Cryptococcus neoformans; D005260:Female; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000097:blood; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011134:Polysaccharides; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole