[Functional indices in assessment of gonarthrosis treatment efficacy with structum and chondrolon].
METHODS
The trial included 50 patients aged from 40 to 67 years with osteoarthrosis (OA) stage I and II by Kellgren-Lawrence. Patients of group 1 (n=30) received chondrolon, of group 2 (n=20)--structum. Treatment efficacy was assessed by WOMAC scale, Leken's functional index, VAS pain at rest, walking, goniometry findings, time of 30 m walking.


RESULTS
A positive clinical effect was achieved in both groups by all the indices. The improvement was significant in VAS pain, functional tests, Leken's index, WOMAC scale. A positive trend in clinical symptoms and tests developed more quickly in the treatment with chondrolon than with structum (in 8 vs. 12 months, respectively). Treatment with different chondroitin sulphate drugs raised quality of life in gonarthrosis patients assessed by WOMAC scale, the effect being comparable.


CONCLUSIONS
Structum and chondrolon can be used for OA stage I-II with moderate dysfunction of knee joints. The treatment course should be long, at least 3 months, 3-6 months for structum.
Maĭko
O Iu
OIu
Bagirova
G G
GG
D000328:Adult; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy*; D011788:Quality of Life / Q000523:psychology; D012720:Severity of Illness Index; D013449:Sulfonamides / Q000627:therapeutic use; D016896:Treatment Outcome
D016861:Cyclooxygenase Inhibitors; D013449:Sulfonamides; D002809:Chondroitin Sulfates; C012655:nimesulide