[Change of concentration endothelin-1 in rats on a background of alcohol and /or mildronate treatment].
Alcoholic cardiomyopathy is specific cardial pathology characteristic for chronic consumption of alcohol. Endothelin-1 is an endothelium-derived potent vasoconstrictor peptide, which level directly influence the severity of this condition. Mildronate is an antiischemic drug. It inhibits carnitine biosynthesis (suppress beta-oxidation of the fatty acids) and increases the production of nitric oxide in the vascular endothelium. The aim of the study was to establish how Mildronate influences concentration of ET-1 in blood of rats on a background of chronic consumption of alcohol and at abstinence. White rats (n=28) instead of drinking water were taking 15% ethanol with the following regimens: A) three-week alcohol consumption, B) after 3 weeks of alcohol consumption on a background of alcohol they took mildronate, C) four-week alcohol consumption; D) after 4 weeks alcohol consumption they took only mildronate. Concentration of ET-1 in the group A was 6,00 +/- 0,35 fmol/ml, in the group B - 4,82 +/- 0,31 fmol/ml, in the group C - 13,25 +/- 0,49 fmol/ml and in the group D - 9,17 +/- 0,17 fmol/ml. Consumption of alcohol concentration ET-1 in blood high, for this purpose it is enough also 3-week alcohol consumption; the concentration of ET-1 progressively elevates with increase of duration of alcohol consumption; mildronate lowers concentration of ET-1 both on the background of alcohol consumption and on the background of acceptance of alcohol; under influence of mildronate the condition is improved in parallel the with complete alcohol consumption and acceptance of alcohol.
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D000428:Alcohol Drinking; D000818:Animals; D002310:Cardiomyopathy, Alcoholic / Q000188:drug therapy*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000097:blood*; D000431:Ethanol / Q000008:administration & dosage; D008297:Male; D008763:Methylhydrazines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D002317:Cardiovascular Agents; D019332:Endothelin-1; D008763:Methylhydrazines; D000431:Ethanol; C050147:3-(2,2,2-trimethylhydrazine)propionate