New developments in natural products-based anti-AIDS research.
This review discusses anti-HIV natural products from several compound classes, including terpenoids, coumarins, alkaloids, polyphenols, tannins, and flavonoids. Natural products can provide novel anti-AIDS chemotherapeutic leads that are structurally unique or have new mechanisms of action. The drug discovery and development process proceeds from bioactivity-directed isolation and identification of a promising lead natural product, followed by rational design-based structural modification and structure-activity relationship analyses to optimize the lead compound as a drug candidate. This process is notably exemplified by the discovery of the modified betulinic acid derivative, DSB [PA-457], which is currently in Phase II clinical trial and is the first-in-class HIV maturation inhibitor (MI).
Yu
Donglei
D
Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Morris-Natschke
Susan L
SL
Lee
Kuo-Hsiung
KH
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000470:Alkaloids / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000145:classification / Q000627:therapeutic use*; D003374:Coumarins / Q000737:chemistry / Q000627:therapeutic use; D015195:Drug Design; D005419:Flavonoids / Q000627:therapeutic use; D006801:Humans; D010636:Phenols / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*; D059808:Polyphenols; D013386:Succinates / Q000737:chemistry / Q000627:therapeutic use; D014315:Triterpenes / Q000737:chemistry / Q000627:therapeutic use; D053978:Pentacyclic Triterpenes
D000470:Alkaloids; D019380:Anti-HIV Agents; D003374:Coumarins; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013386:Succinates; D014315:Triterpenes; C479935:bevirimat; D053978:Pentacyclic Triterpenes