CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea.
In a nested-case control study of 100 cases of gastric cancer and 400 matched controls in relation to virulence factors of Helicobacter pylori in a Korean cohort, CagA seropositivity was significantly associated with a higher risk of gastric cancer among H. pylori-infected subjects (OR=3.57, 95% CI 1.05-12.14).
Gwack
J
J
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Korea.
Shin
A
A
Kim
C-S
CS
Ko
K-P
KP
Kim
Y
Y
Jun
J K
JK
Bae
J
J
Park
S K
SK
Hong
Y-C
YC
Kang
D
D
Chang
S-H
SH
Shin
H-R
HR
Yoo
K-Y
KY
D000368:Aged; D000428:Alcohol Drinking; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000382:microbiology*; D014774:Virulence
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori