title: Malignant blue nevus of the parotid gland: A case report.
abstract: BACKGROUND
  Malignant blue nevus is a highly aggressive tumor arising from a background of benign blue nevus. Extensive review of the medical literature revealed a few reported cases of this transformation from cutaneous origin. We report the first case of blue nevus of the parotid gland and its malignant transformation within this gland.
  
  
  METHODS
  A 62-year-old woman presented to our clinic with sudden onset parotid mass. After a superficial parotidectomy, histologic examination of the specimen was performed. Features compatible with blue nevus with focal region of atypical mitotic activity were evident. The diagnosis of malignant blue nevus was confirmed by immunohistochemical studies.
  
  
  RESULTS
  We report the first case of malignant transformation of blue nevus within the parotid gland.
  
  
  CONCLUSIONS
  We found this lesion to be highly aggressive and to have metastasized shortly after diagnosis.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, Garneau Professional Center, University of Alberta, #401, 11044-82 Avenue, Edmonton, AB, Canada T6G 0T2.
authors.forename: Ali
authors.initials: A
authors.lastname: Moshaver
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Puttagunta
authors.forename: Hadi
authors.initials: H
authors.lastname: Seikaly
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008875:Middle Aged; D018329:Nevus, Blue / Q000175:diagnosis / Q000473:pathology*; D010306:Parotid Gland / Q000473:pathology*; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D009418:S100 Proteins; D014746:Vimentin