title: Avinosol, a meroterpenoid-nucleoside conjugate with antiinvasion activity isolated from the marine sponge Dysidea sp.
abstract: [structure: see text] The new meroterpenoids avinosol (1), 3'-aminoavarone (2), and 3'-phenethylaminoavarone (3) have been isolated from the marine sponge Dysidea sp. collected in Papua New Guinea, and their structures were elucidated by analysis of spectroscopic data. Avinosol (1), which is apparently the first example of a naturally occurring meroterpenoid-nucleoside conjugate, showed antiinvasion activity in a cell-based assay.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Diaz-Marrero
authors.forename: Pamela
authors.initials: P
authors.lastname: Austin
authors.forename: Rob
authors.initials: R
authors.lastname: Van Soest
authors.forename: Teatulohi
authors.initials: T
authors.lastname: Matainaho
authors.forename: Calvin D
authors.initials: CD
authors.lastname: Roskelley
authors.forename: Michel
authors.initials: M
authors.lastname: Roberge
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D047088:Dysidea / Q000737:chemistry*; D005260:Female; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes; C520166:avinosol