title: CD24 V/V is an allele associated with the risk of developing multiple sclerosis in the Spanish population.
abstract: The allele C in the CD24 gene has been related to multiple sclerosis (MS). In this work we check this single nucleotide polymorphism (SNP) in a population of 135 patients and 285 controls. Our results confirm the association between the V/V genotype at aa 57 of this gene and MS and highlight the importance of taking into account the origin of the subjects to avoid a population bias.
authors.affiliation: Unidad Experimental, Hospital Donostia, San Sebastián, Spain. uniexpe2@chdo.osakidetza.net
authors.forename: D
authors.initials: D
authors.lastname: Otaegui
authors.forename: A
authors.initials: A
authors.lastname: Sáenz
authors.forename: P
authors.initials: P
authors.lastname: Camaño
authors.forename: L
authors.initials: L
authors.lastname: Blázquez
authors.forename: M
authors.initials: M
authors.lastname: Goicoechea
authors.forename: J
authors.initials: J
authors.lastname: Ruíz-Martínez
authors.forename: J
authors.initials: J
authors.lastname: Olaskoaga
authors.forename: J A
authors.initials: JA
authors.lastname: Emparanza
authors.forename: A
authors.initials: A
authors.lastname: López de Munain
mesh_terms: D000328:Adult; D051927:CD24 Antigen / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D044465:White People / Q000235:genetics
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human