Language dominance in mesial temporal lobe epilepsy: a functional transcranial Doppler sonography study of brain plasticity.
Functional transcranial Doppler sonography was used to study hemispheric language dominance (HLD) in 24 right-handed patients with left temporal lobe epilepsy (TLE) and a structural lesion in the left temporal lobe and in 69 healthy controls. Twenty-five percent of the patients and 4% of controls showed atypical (right or bilateral) HLD. Degree of HLD was not correlated with age, Full Scale IQ, Verbal IQ, spike frequency, seizure frequency, age at seizure onset, or duration of TLE. Atypical HLD appears to be lesion-induced, independent of epilepsy characteristics.
Knake
Susanne
S
Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Rudolf-Bultmann-Strasse 8, 35033 Marburg, Germany. knake@staff.uni-marburg.de
Haag
Anja
A
Pilgramm
Guido
G
Dittmer
Christine
C
Reis
Janine
J
Assmann
Heike
H
Oertel
Wolfgang H
WH
Rosenow
Felix
F
Hamer
Hajo M
HM
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004292:Dominance, Cerebral; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity; D011300:Preoperative Care; D012016:Reference Values; D012598:Sclerosis; D017585:Ultrasonography, Doppler, Transcranial