Synthesis and antitumour activity of new muricatacin and goniofufurone analogues.
A divergent approach to the 7-oxa (-)-muricatacin analogue 2, the corresponding (+)-enantiomer ent-2 and the furanolactone 3 is reported starting from D-xylose. The resulting lactones have shown a potent and selective in vitro cytotoxicity against certain human neoplastic cell lines.
Popsavin
Velimir
V
Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia. popsavin@ih.ns.ac.yu
Srećo
Bojana
B
Krstić
Ivana
I
Popsavin
Mirjana
M
Kojić
Vesna
V
Bogdanović
Gordana
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones; C082488:muricatacin; C073080:7-goniofufurone