title: Inverse correlation between serum free IGF-I and IGFBP-3 levels and blood pressure in patients affected with type 1 diabetes.
abstract: BACKGROUND
  Even though the gene encoding for IGF-I is considered of most importance amongst blood pressure-regulating genes in mouse models, little and discordant data are available in literature for what concerns a possible relationship between blood pressure and serum free IGF-I values in humans. In addition, no information is available on type 1 diabetes patients.
  
  
  OBJECTIVE
  Our aim is to analyze the relationship between systolic and diastolic blood pressure and serum free IGF-I and IGFBP-3 levels in subjects suffering from type 1 diabetes.
  
  
  RESULTS
  A highly significant inverse correlation was observed between serum free IGF-I levels and both systolic and diastolic blood pressure in subjects affected with type 1 diabetes. Similar but less significant relationships were observed for IGFBP-3, whose levels were also significantly and directly correlated with those of free IGF-I. The correlation between systolic and diastolic blood pressures with free IGF-I and between systolic blood pressure and IGFBP-3 levels were confirmed after adjusting for age, gender, age at diagnosis, disease duration, familial history, HBA1c, and amount of insulin administered by multivariate logistic regression analysis. A decrease in free IGF-I and IGFBP-3 levels, along with increases in blood pressure, significantly influenced the presence of diabetic complications, confirming how these molecules may be considered as severity markers for patients with type 1 diabetes as well as risk factors for altered pressure control linked diseases.
authors.affiliation: Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy. ecapoluongo@rm.unicatt.it
authors.forename: Ettore
authors.initials: E
authors.lastname: Capoluongo
authors.forename: Dario
authors.initials: D
authors.lastname: Pitocco
authors.forename: Paola
authors.initials: P
authors.lastname: Lulli
authors.forename: Angelo
authors.initials: A
authors.lastname: Minucci
authors.forename: Concetta
authors.initials: C
authors.lastname: Santonocito
authors.forename: Andrea
authors.initials: A
authors.lastname: Manto
authors.forename: Enrico
authors.initials: E
authors.lastname: Di Stasio
authors.forename: Francesco
authors.initials: F
authors.lastname: Zaccardi
authors.forename: Cecilia
authors.initials: C
authors.lastname: Zuppi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ghirlanda
authors.forename: Franco
authors.initials: F
authors.lastname: Ameglio
mesh_terms: D000328:Adult; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000145:classification / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D044967:Serum
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I