Validation of the genital herpes treatment satisfaction questionnaire (GHerpTSQ) in status and change versions.
A new measure of treatment satisfaction (GHerpTSQ) for recurrent genital herpes simplex virus (HSV) was validated and used to evaluate two therapeutic strategies widely used for the management of HSV: episodic treatment, where individual herpes outbreaks are treated as they arise; suppressive therapy, where treatment is taken daily to prevent HSV outbreaks. Satisfaction with treatment is important since daily dosing with suppressive therapy is necessary in the absence of symptoms. A 12-item questionnaire was designed using a modified form of the Diabetes treatment satisfaction questionnaire (DTSQ). The psychometric properties of the GHerpTSQ were evaluated within a sample of 125 Canadians with a history of HSV (type 1, 2) infection participating in a 48 week randomised cross-over trial. Factor analysis suggested that the items can be analysed as two separate subscales corresponding to Control/effectiveness, and Convenience/lifestyle; the single item concerning side effects was retained for separate analysis. Forced one-factor analysis showed that the two subscales can be combined to obtain a total score relating to overall treatment satisfaction. The GHerpTSQ has good internal reliability, clear structure with little overlap of subscales and evidence of good sensitivity to changes in treatment.
Taback
Nathan Asher
NA
Department of Public Health Sciences, University of Toronto, and St. Michael's Hospital, Toronto, ON, Canada. tabackn@smh.toronto.on.ca
Bradley
Clare
C
D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods*; D017060:Patient Satisfaction; D011594:Psychometrics / Q000295:instrumentation*; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use
D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir