title: The mycobacterium-specific gene Rv2719c is DNA damage inducible independently of RecA.
abstract: The mycobacterium-specific gene Rv2719c was found to be expressed primarily from a promoter that was clearly DNA damage inducible independently of RecA. Upstream of the transcriptional start site for this promoter, sequence motifs resembling those observed previously at the RecA-independent, DNA damage-inducible recA promoter were identified, and the -10 motif was demonstrated by mutational analysis in transcriptional fusion constructs to be important for expression of Rv2719c.
authors.affiliation: Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, United Kingdom.
authors.forename: Patricia C
authors.initials: PC
authors.lastname: Brooks
authors.forename: Lisa F
authors.initials: LF
authors.lastname: Dawson
authors.forename: Lucinda
authors.initials: L
authors.lastname: Rand
authors.forename: Elaine O
authors.initials: EO
authors.lastname: Davis
mesh_terms: D001483:Base Sequence; D004249:DNA Damage / Q000502:physiology*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D011938:Rec A Recombinases / Q000378:metabolism*; D024363:Transcription Initiation Site
chemical_list: D004269:DNA, Bacterial; D011938:Rec A Recombinases