An 18-case outbreak of drug-resistant Pseudomonas aeruginosa bacteriemia in hematology patients.
We retrospectively identified an outbreak of 18 episodes of P. aeruginosa bacteriemia in 17 patients with hematologic malignancies in 2004. All strains were ticarcillin I/R, 77% ciprofloxacin I/R, 72% ceftazidime I/R, 72% amikacin I/R and 50% imipenem I/R. The outbreak was multiclonal. Colistin was employed for documented therapy in ten cases including seven in which it was the only active drug. Outcomes were resolution of infection in 12 out of 18 episodes (67%), and death in six cases, five (25%) of which were attributable to the infection. Colistin was useful even in highly resistant strains and the efficacy of antibacterial therapy was similar (57%)in bacteriemia due to strains only susceptible to colistin.
Micol
Jean Baptiste
JB
Service des Maladies du Sang, CHRU, Lille, France.
de Botton
Stéphane
S
Guieze
Romain
R
Coiteux
Valérie
V
Darre
Stéphane
S
Dessein
Rodrigue
R
Leroy
Olivier
O
Yakoub-Agha
Ibrahim
I
Quesnel
Bruno
B
Bauters
Francis
F
Beaucaire
Gilles
G
Alfandari
Serge
S
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000453:epidemiology / Q000401:mortality; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D019337:Hematologic Neoplasms / Q000150:complications / Q000382:microbiology*; D006801:Humans; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D011550:Pseudomonas aeruginosa; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents