[Distribution of HLA class I antigens in patients with uveitis in the presence of rheumatic diseases].
Uveitis associated with rheumatic diseases (RD) is one of the symptoms of an autoimmune lesion. A great role in the etiology of the latter is assigned to genetic predisposition, HLA antigens in particular. Twenty-four HLA class I antigens were histotyped, by applying the Terasaki microlymphocytotoxic test in 83 patients with uveitis in the presence of different types of RD. All the patients and 701 healthy donors making up a control group were Caucasians. The results were statistically processed. There was a significant increase in the incidence of the antigens of HLA B27 (RR = 10.04; p < 0.01) and A2 (RR = 1.84; p < 0.05) and a decrease in that of the antigens of HLA A10, B5, B10, and B13 (p < 0.05). There was evidence for that there was an association of the antigen of HLA B27 with acute anterior uveitis and that of the antigens B 8 and B 35 with posterior and generalized uveitis in RD. The specific features of the association of antigens and their haplotypes in individual nosological entities of RD are presented.
Drozdova
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EA
D000293:Adolescent; D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012216:Rheumatic Diseases / Q000150:complications* / Q000276:immunology; D014605:Uveitis / Q000150:complications / Q000235:genetics / Q000276:immunology*
D015395:Histocompatibility Antigens Class I