Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa.
A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP). Neither myeloperoxidase- nor proteinase-3-antineutrophil cytoplasmic antibody was positive. These manifestations met the American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Stopping minocycline led to amelioration of symptoms and normalization of CRP level. To our knowledge, this is the second case of minocycline-induced vasculitis satisfying the criteria. Differential diagnosis for drug-induced disease is invaluable even for patients with classical polyarteritis nodosa.
Katada
Yoshinori
Y
Division of Allergy and Clinical Immunology, National Hospital Organization, Osaka-Minami Medical Center, 2-1 Kido-higashi, Kawachinagano, 586-8521, Japan. kataday@omh.hosp.go.jp
Harada
Yoshinori
Y
Azuma
Naoto
N
Matsumoto
Kengo
K
Terada
Haruko
H
Kudo
Eriko
E
Ishii
Masaru
M
Yamane
Hiroyuki
H
Yamamoto
Suguru
S
Ohshima
Shiro
S
Mima
Toru
T
Tanaka
Toshio
T
Saeki
Yukihiko
Y
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D018771:Arthralgia / Q000139:chemically induced; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D010292:Paresthesia / Q000139:chemically induced; D010488:Polyarteritis Nodosa / Q000139:chemically induced*; D011565:Psoriasis / Q000188:drug therapy*; D013737:Testis
D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein; D008911:Minocycline