title: Long-term follow-up of blood lead levels and haematological and biochemical parameters in heifers that survived an accidental lead poisoning episode.
abstract: Four of 10 heifers that survived an episode of lead poisoning caused by an old broken battery in the pasture were periodically monitored from days 14 to 205 after the episode, with the aim of (i) determining the time-course of lead clearance from blood; and (ii) assessing whether the exposed cattle showed changes in haematological parameters or serum markers of hepatic and renal function (e.g. serum creatinine level) that might be useful as indicators of subclinical toxicity. On the first sampling day, lead levels in blood varied between 0.478 and 0.758 mg/l. The half-life of lead in blood was rather variable, ranging from 68 to 266 days. Despite the high blood lead levels, no significant changes were detected in haematological parameters or hepatic/renal markers, all of which remained within normal ranges. In conclusion, these cattle that survived an episode of lead poisoning may constitute a risk for human consumers, but do not appear to have suffered severe health consequences themselves.
authors.affiliation: Departamento de Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, 27002 Lugo, Spain. mmiranda@lugo.usc.es
authors.forename: M
authors.initials: M
authors.lastname: Miranda
authors.forename: M
authors.initials: M
authors.lastname: López-Alonso
authors.forename: P
authors.initials: P
authors.lastname: García-Partida
authors.forename: J
authors.initials: J
authors.lastname: Velasco
authors.forename: J L
authors.initials: JL
authors.lastname: Benedito
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D002417:Cattle / Q000097:blood*; D003257:Consumer Product Safety; D005260:Female; D006207:Half-Life; D007854:Lead / Q000097:blood / Q000493:pharmacokinetics*; D007855:Lead Poisoning / Q000097:blood / Q000662:veterinary*; D008460:Meat / Q000032:analysis; D013997:Time Factors
chemical_list: D007854:Lead