title: Hyperfunctioning intrathyroidal parathyroid carcinoma.
abstract: Intrathyroidal parathyroid carcinoma is an exceedingly rare cause of primary hyperparathyroidism with difficulties in the diagnosis and management. We report a case of hypercalcemia from intrathyroidal parathyroid carcinoma in a 63-year-old Saudi female. She was diagnosed 2 years earlier with osteoporosis in a primary care clinic and was on alendronate since then. This year she was noted to have hypercalcemia, but in retrospect she had more than 10 years history of multiple medical problems related to hypercalcemia. Parathyroid 99mTc-SestaMIBI scintigraphy revealed parathyroid adenoma in the left inferior parathyroid gland. She had successful video-assisted parathyroidectomy that relieved most of her symptoms. The extreme rarity of such a case, the interesting clinical presentation and review of the literature are discussed.
authors.affiliation: Section Head, Diabetes and Endocrinology Center, PO Box 35051, Dammam 31488, Kingdom of Saudi Arabia. husseinw@pol.net
authors.forename: Wiam I
authors.initials: WI
authors.lastname: Hussein
authors.forename: Tarek A
authors.initials: TA
authors.lastname: El-Maghraby
authors.forename: Osama
authors.initials: O
authors.lastname: Al-Sanea
mesh_terms: D002277:Carcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis* / Q000209:etiology*; D006961:Hyperparathyroidism / Q000150:complications; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D013965:Thyroidectomy; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi