title: [Gastroesophageal reflux disease and dyspepsia--drug therapy].
abstract: Proton pump inhibitors (PPI) are the antisecretory drugs of choice to manage GERD-related problems. The therapeutic goal in patients with non erosive reflux disease (NERD) and low-grade-GERD is to relieve symptoms, therefore PPI are given "on demand". Severe GERD requires long term treatment to heal lesions and to prevent relapses and complications. Barrett's esophagus has to be regarded as a precancerous lesion, therefore surveillance strategy is required. Functional dyspepsia is a common reason for upper gastrointestinal symptoms. If there are no alarming symptoms, you can omit endoscopy in younger patients. The treatment is empirical and symptom driven. Psychologic therapy is a promising avenue in some patients.
authors.affiliation: Klinik für Onkologie, Gastroenterologie und Allgemeine Innere Medizin, Städtische Kliniken Esslingen.
authors.forename: H
authors.initials: H
authors.lastname: Gräter
mesh_terms: D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004415:Dyspepsia / Q000188:drug therapy* / Q000209:etiology; D004942:Esophagitis, Peptic / Q000188:drug therapy* / Q000209:etiology; D004945:Esophagoscopy; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008134:Long-Term Care; D054328:Proton Pump Inhibitors; D012307:Risk Factors; D055502:Secondary Prevention
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors