Haptoglobin gene promoter polymorphism and haplotypes are unique in different populations.
We investigated the distribution of haptoglobin (HP) alleles and haplotypes among Africans (Ghanaians), Europeans (from South Africa), and Chinese. HP*1F was present only in Africans and Europeans, whereas HP*del was unique to Chinese. Six base substitutions at the promoter region were population specific. Only 3 out of 18 haplotypes were shared among the populations. A probable application of HP in human population genetics appears legitimate.
Teye
Kwesi
K
Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Japan.
Soejima
Mikiko
M
Quaye
Isaac K E
IK
Pang
Hao
H
Tsuneoka
Makoto
M
Koda
Yoshiro
Y
Kimura
Hiroshi
H
D000349:Africa; D000483:Alleles; D002681:China; D005060:Europe; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics*; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*
D006242:Haptoglobins