title: Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species.
abstract: Xanthonol, a novel dimeric xanthone, was isolated from a fermentation broth of a non-sporulating fungal species using Sephadex LH20 followed by HPLC and the structure elucidated by spectral analysis. Xanthonol exhibited insecticidal and anthelmintic activities against larvae of Lucilia sericata, Aedes aegypti, and Haemonchus contortus with LD90 of 33, 8, and 50 microg/ml, respectively.
authors.affiliation: Merck Research Laboratories, Merck & Co., Inc. PO Box 2000, R80Y-355, Rahway, New Jersey 07065, USA. john_ondeyka@merck.com
authors.forename: John G
authors.initials: JG
authors.lastname: Ondeyka
authors.forename: Anne W
authors.initials: AW
authors.lastname: Dombrowski
authors.forename: Jon P
authors.initials: JP
authors.lastname: Polishook
authors.forename: Tom
authors.initials: T
authors.lastname: Felcetto
authors.forename: Wesley L
authors.initials: WL
authors.lastname: Shoop
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Guan
authors.forename: Sheo B
authors.initials: SB
authors.lastname: Singh
mesh_terms: D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D021241:Spectrometry, Mass, Electrospray Ionization; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000871:Anthelmintics; D007306:Insecticides; D044004:Xanthones; C512872:xanthonol