Cellular immune response of patients with chromoblastomycosis undergoing antifungal therapy.
One of the most characteristic features of the chromoblastomycosis is its unresponsiveness to treatment. In order to analyzed whether during therapy could be observed a change of cellular immune response pattern, we evaluated the production of IL-10, TNF-alpha and IFN-gamma, as well as proliferation of peripheral blood mononuclear cell (PBMC) from patients in different periods of chemotherapy treatment. Our results showed that after 6 months of treatment cells from patients proliferated to fungal antigens and produced a significant level of IFN-gamma. However, after 1 year of treatment a low proliferation of T cells and production of IFN-gamma accompanied by an increase of IL-10 were observed when compared with 6 months of treatment.
Gimenes
Viviane Mazo Fávero
VM
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 17, São Paulo, CEP: 05508-900, Brazil.
Criado
Paulo Ricardo
PR
Martins
José Eduardo Costa
JE
Almeida
Sandro Rogério
SR
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000276:immunology; D001203:Ascomycota / Q000302:isolation & purification; D049109:Cell Proliferation; D002862:Chromoblastomycosis / Q000188:drug therapy* / Q000276:immunology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology*; D000077291:Terbinafine; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000935:Antifungal Agents; D000946:Antigens, Fungal; D009281:Naphthalenes; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D017964:Itraconazole; D007371:Interferon-gamma; D000077291:Terbinafine