title: Comparison of advanced irradiation techniques with photons for benign intracranial tumours.
abstract: OBJECTIVE
  The potential benefits and limitations of different radiation techniques (stereotactic arc therapy (SRS/T), intensity modulated radiotherapy (IMRT), helical tomotherapy (HT), Cyberknife and intensity-modulated multiple arc therapy (AMOA)) have been assessed using comparative treatment planning methods on twelve patients presenting with 'benign' brain tumours.
  
  
  METHODS
  Plans for five acoustic neurinomas, five meningiomas and two pituitary adenomas were computed to generate dose distributions for all modalities using a common CT dataset to delineate planning target volume and organs at risk.
  
  
  RESULTS
  HT, AMOA and IMRT resulted superior to SRS/T and Cyberknife for target coverage. For the first group V(95%) ranged from 98% to 100%, minimum dose ranged from 91% to 96% and standard deviation from 0.84% to 1.67%. For organs at risk all techniques respected planning objectives with a tendency of Cyberknife and SRS/T to better spare the brain stem and the healthy brain tissue (e.g., V(20Gy) of 2.0% and 2.3%, respectively, compared to 3.1-5.0% for the other techniques). AMOA is in general preferable to IMRT for all OARs. Conformity index (CI(95)) was better for HT and Cyberknife (both 1.8) and less for AMOA and IMRT (3.9 and 3.0, respectively).
  
  
  CONCLUSIONS
  All techniques provided good OAR sparing and primarily differed in target coverage indices. For the class of tumours investigated in this report, HT, AMOA and IMRT had better target coverage with HT providing the best combination of indeces. Between AMOA and IMRT, target coverage was comparable and, considering organs at risk, AMOA was slightly preferable.
authors.affiliation: Oncology Institute of Southern Switzerland, Medical Physics, Bellinzona, Switzerland. lucozzi@iosi.ch <lucozzi@iosi.ch>
authors.forename: L
authors.initials: L
authors.lastname: Cozzi
authors.forename: A
authors.initials: A
authors.lastname: Clivio
authors.forename: G
authors.initials: G
authors.lastname: Bauman
authors.forename: S
authors.initials: S
authors.lastname: Cora
authors.forename: G
authors.initials: G
authors.lastname: Nicolini
authors.forename: R
authors.initials: R
authors.lastname: Pellegrini
authors.forename: E
authors.initials: E
authors.lastname: Vanetti
authors.forename: S
authors.initials: S
authors.lastname: Yartsev
authors.forename: A
authors.initials: A
authors.lastname: Fogliata
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008579:Meningioma / Q000532:radiotherapy; D009442:Neurilemmoma / Q000532:radiotherapy; D017785:Photons / Q000627:therapeutic use*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D013238:Stereotaxic Techniques; D036542:Tomography, Spiral Computed / Q000379:methods