Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach.
In the present study, which includes 287 participants, metformin has been used by women undergoing IVF/intracytoplasmic sperm injection for more than 5 weeks before and during treatment and during luteal phase. There was no significant difference in number of gonadotrophins used, days of stimulation, number of oocytes retrieved, and number of embryos replaced. There was no significant difference in clinical pregnancy rate between both groups but there was significant reduction in the incidence of ovarian hyperstimulation syndrome (OHSS) in the group taking metformin. Metformin is a safe, cheap drug that can help in prevention of OHSS.
Khattab
Sherif
S
Department of Obstetrics and Gynecology, Cairo University, Misr International Hospital, 40, Abdel Rehim Sabry St, Dokki, Cairo, Egypt. eifc@soficom.com.eg
Fotouh
Ismail Aboul
IA
Mohesn
Iman Abdel
IA
Metwally
Mostapha
M
Moaz
Mohamed
M
D000328:Adult; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D004967:Estrogens / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006801:Humans; D007049:Iatrogenic Disease / Q000517:prevention & control*; D007247:Infertility, Female / Q000188:drug therapy; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D009865:Oocytes / Q000187:drug effects; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects
D004967:Estrogens; D005640:Follicle Stimulating Hormone; D008687:Metformin