title: Cellular immune response of patients with chromoblastomycosis undergoing antifungal therapy.
abstract: One of the most characteristic features of the chromoblastomycosis is its unresponsiveness to treatment. In order to analyzed whether during therapy could be observed a change of cellular immune response pattern, we evaluated the production of IL-10, TNF-alpha and IFN-gamma, as well as proliferation of peripheral blood mononuclear cell (PBMC) from patients in different periods of chemotherapy treatment. Our results showed that after 6 months of treatment cells from patients proliferated to fungal antigens and produced a significant level of IFN-gamma. However, after 1 year of treatment a low proliferation of T cells and production of IFN-gamma accompanied by an increase of IL-10 were observed when compared with 6 months of treatment.
authors.affiliation: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 17, São Paulo, CEP: 05508-900, Brazil.
authors.forename: Viviane Mazo Fávero
authors.initials: VM
authors.lastname: Gimenes
authors.forename: Paulo Ricardo
authors.initials: PR
authors.lastname: Criado
authors.forename: José Eduardo Costa
authors.initials: JE
authors.lastname: Martins
authors.forename: Sandro Rogério
authors.initials: SR
authors.lastname: Almeida
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000276:immunology; D001203:Ascomycota / Q000302:isolation & purification; D049109:Cell Proliferation; D002862:Chromoblastomycosis / Q000188:drug therapy* / Q000276:immunology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology*; D000077291:Terbinafine; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D009281:Naphthalenes; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D017964:Itraconazole; D007371:Interferon-gamma; D000077291:Terbinafine