[Mutation in factor II and factor V gene in patients with peripheral arterial occlusive disease].
Mutations in factor-V- and factor-II-genes are correlated with an increased risk for venous thrombosis according to the literature. The significance of the mutations in factor- II- and factor-V-genes for the development of the peripheral arterial occlusive disease is not known. Therefore, we investigated the presence of these mutations in 152 patients with documented peripheral arterial occlusive disease and 318 controls without peripheral arterial occlusive disease with polymerase chain reaction (PCR). There was no association between factor-II-mutation and peripheral arterial occlusive disease. The factor-V-mutation, however, was increased in patients with peripheral arterial occlusive disease double fold (12 positive cases in 318 controls, 12 positive cases in 152 patients with peripheral arterial occlusive disease). The significance level was reached (p = 0.05) in statistical analysis but the result did not fall below the significance level as necessary to reach statistical significance (odds ratio 2.19). Nevertheless, from these data we have to discuss a biological relevance of factor-V-mutation in the pathogenesis of peripheral arterial occlusive disease.
Abukishe
A
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Universitätsklinikum Schleswig-Holstein/Campus Kiel, I. Medizinische Universitätsklinik, Schlittenhelmstr. 12, 24105 Kiel.
Brandt
M
M
Hedderich
J
J
Hirt
S
S
Lentz
S
S
Schäfer
H
H
Walluscheck
K
K
Cremer
J
J
Bruhn
H D
HD
D001157:Arterial Occlusive Diseases / Q000097:blood / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000235:genetics; D008297:Male; D009154:Mutation; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D012016:Reference Values; D013927:Thrombosis / Q000097:blood / Q000235:genetics
D005165:Factor V; D011516:Prothrombin