The Norton-Simon hypothesis: designing more effective and less toxic chemotherapeutic regimens.
Simon
Richard
R
Biometric Research Branch, National Cancer Institute, Bethesda, MD 20892, USA. rsimon@mail.nih.gov
Norton
Larry
L
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D018570:Risk Assessment; D047368:Tumor Burden / Q000187:drug effects