Modeling the contribution of lamina 5 neuronal and network dynamics to low frequency EEG phenomena.
The Electroencephalogram (EEG) is an important clinical and research tool in neurophysiology. With the advent of recording techniques, new evidence is emerging on the neuronal populations and wiring in the neocortex. A main challenge is to relate the EEG generation mechanisms to the underlying circuitry of the neocortex. In this paper, we look at the principal intrinsic properties of neocortical cells in layer 5 and their network behavior in simplified simulation models to explain the emergence of several important EEG phenomena such as the alpha rhythms, slow-wave sleep oscillations, and a form of cortical seizure. The models also predict the ability of layer 5 cells to produce a resonance-like neuronal recruitment known as the augmenting response. While previous models point to deeper brain structures, such as the thalamus, as the origin of many EEG rhythms (spindles), the current model suggests that the cortical circuitry itself has intrinsic oscillatory dynamics which could account for a wide variety of EEG phenomena.
Karameh
Fadi N
FN
Department of Electrical and Computer Engineering, American University of Beirut, Beirut, Lebanon. fk14@aub.edu.lb
Dahleh
Munther A
MA
Brown
Emery N
EN
Massaquoi
Steve G
SG
D000818:Animals; D003198:Computer Simulation; D004558:Electric Stimulation / Q000379:methods; D004569:Electroencephalography; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D008959:Models, Neurological; D019579:Neocortex / Q000166:cytology* / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D016571:Neural Networks, Computer; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D017711:Nonlinear Dynamics; D018079:Receptors, GABA / Q000502:physiology; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
D018690:Excitatory Amino Acid Agonists; D018079:Receptors, GABA; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid