title: Oxidative stress is decreased in off-pump versus on-pump coronary artery surgery.
abstract: Oxidative stress occurs in patients undergoing coronary artery bypass operation. The aim of this study was to investigate the difference in oxidative stress in off-pump versus on-pump coronary artery bypass surgery. In the present study, in serial blood samples, plasma malondialdehyde (MDA) as index of lipid peroxidation, red blood cells glutathione peroxidase (GPx) and superoxide dismutase (SOD) were measured to compare the extent of oxidative stress in 30 patients undergoing OPCAB (off-pump coronary artery bypass grafting), 12 patients undergoing CABG (on-pump coronary artery bypass grafting) and 18 healthy controls. In CABG group, MDA levels increased significantly from 2.87 +/- 0.62 nmol/mL before anesthesia and 2.87 +/- 0.65 nmol/mL after anesthesia to 3.05 +/- 0.66 nmol/mL after ischemia (p < 0.05). Similarly, SOD levels also elevated significantly from 661.58 +/- 78.70 U/g Hb before anesthesia and 659.42 +/- 81.21 U/g Hb anesthesia induction to 678.08 +/- 75.80 U/g Hb after ischemia (p < 0.01, p < 0.01, respectively). In OPCAB group, only SOD levels increased from 581.73 +/- 86.24 U/g Hb anesthesia induction to 590.90 +/- 88.90 U/g Hb after reperfusion (p < 0.05). Glutathione peroxidase levels were not changed according to blood collection times in both of CABG group or OPCAB group (p > 0.05). Our results show that only mild signs of oxidative stress is found after reperfusion in OPCAB operation compared with CABG operation. Further studies are needed in order to confirm this hypothesis.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey. aymelek@gazi.edu.tr
authors.forename: Aymelek
authors.initials: A
authors.lastname: Gönenç
authors.forename: Aysun
authors.initials: A
authors.lastname: Hacişevki
authors.forename: Beyhan
authors.initials: B
authors.lastname: Bakkaloğlu
authors.forename: Aylin
authors.initials: A
authors.lastname: Soyağir
authors.forename: Meral
authors.initials: M
authors.lastname: Torun
authors.forename: Haldun
authors.initials: H
authors.lastname: Karagöz
authors.forename: Bolkan
authors.initials: B
authors.lastname: Simşek
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D001026:Coronary Artery Bypass / Q000379:methods*; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase