Surgical site infections after thyroidectomy.
BACKGROUND
The history of thyroid surgery starts with Billroth, Kocher, and Halsted, who developed techniques for thyroidectomy between 1873 and 1910. Before 1950, the operative mortality rate approached 50%. The advent of general anesthesia and antisepsis and the development of fine hemostatic instruments rendered thyroid surgery safer, but the potential persists for life-threatening complications. This study was designed to identify specific risk factors for the development of surgical site infections (SSIs); to define high-risk patients; to determine the causative organisms; to illustrate the clinical presentation, treatment, and outcome; and to establish management guidelines.


METHODS
A prospective analysis was carried out of complications affecting 241 consecutive patients (mean age 65+/-19 years; 76% female) undergoing cervical exploration for thyroid disease from 2000 to 2005, with particular attention to infection, and the pertinent literature was reviewed.


RESULTS
Surgical site infections (SSI) affected 2% of patients. The risk of infection depended mainly on the quality of pre-operative and post-operative care and on whether there was a break in sterile technique. The use of drains and pre-operative antibiotics did not affect the incidence of SSI. No pre-operative factor foreshadowed this complication, and the definition of a high-risk population remains obscure. Surgical site infections lengthened the hospital stay.


CONCLUSIONS
Effort should be made to improve sterile technique. Appropriate antibiotic coverage is indicated when infection develops post-operatively. The most important element in the management of SSI is adequate drainage of the incision once infection develops.
Dionigi
Gianlorenzo
G
Department of Surgical Sciences, University of Insubria, Varese, Italy. gianlorenzo.dionigi@uninsubria.it
Rovera
Francesca
F
Boni
Luigi
L
Castano
Patrizia
P
Dionigi
Renzo
R
D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D013211:Staphylococcus aureus; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology* / Q000503:physiopathology; D013965:Thyroidectomy / Q000009:adverse effects*