title: Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.
authors.affiliation: Department of Medicinal Chemistry, Technology Enabled Synthesis Group, Merck Research Laboratories, P.O. Box 4, West Point, PA 19486, USA. craig_lindsley@merck.com
authors.forename: Craig W
authors.initials: CW
authors.lastname: Lindsley
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Zhao
authors.forename: William H
authors.initials: WH
authors.lastname: Leister
authors.forename: Julie
authors.initials: J
authors.lastname: O'Brien
authors.forename: Wei
authors.initials: W
authors.lastname: Lemaire
authors.forename: David L
authors.initials: DL
authors.lastname: Williams
authors.forename: Tsing-Bau
authors.initials: TB
authors.lastname: Chen
authors.forename: Raymond S L
authors.initials: RS
authors.lastname: Chang
authors.forename: Maryann
authors.initials: M
authors.lastname: Burno
authors.forename: Marlene A
authors.initials: MA
authors.lastname: Jacobson
authors.forename: Cyrille
authors.initials: C
authors.lastname: Sur
authors.forename: Gene G
authors.initials: GG
authors.lastname: Kinney
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Pettibone
authors.forename: Philip R
authors.initials: PR
authors.lastname: Tiller
authors.forename: Sheri
authors.initials: S
authors.lastname: Smith
authors.forename: Nancy N
authors.initials: NN
authors.lastname: Tsou
authors.forename: Mark E
authors.initials: ME
authors.lastname: Duggan
authors.forename: P Jeffrey
authors.initials: PJ
authors.lastname: Conn
authors.forename: George D
authors.initials: GD
authors.lastname: Hartman
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001549:Benzamides / Q000737:chemistry*; D015195:Drug Design; D050487:Glycine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors*; D051379:Mice; D008811:Mice, Inbred DBA; D051381:Rats; D012559:Schizophrenia / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D014150:Antipsychotic Agents; D001549:Benzamides; D050487:Glycine Plasma Membrane Transport Proteins; D013449:Sulfonamides