Can PACAP-38 modulate immune and endocrine responses during lipopolysaccharide (LPS)-induced acute inflammation?
Pituitary adenylate cyclase-activating polypeptide (PACAP) shows a potential anti-inflammatory activity and interacts with the endocrine system. The aim of the present article was to evaluate the effects of PACAP38 on the endocrine and immune systems during acute inflammation. Rats used in the experiments, divided into four groups, were given intraperitoneal injection of, respectively 0.9% NaCl, LPS, PACAP38, and LPS+PACAP38. Hormone (pituitary, adrenal, and thyroid) and cytokine (TNF-alpha, IL-6, IL10) concentrations were measured 2 and 4 h after the injection. Treatment with LPS + PACAP, as compared to LPS, caused TNF-alpha and corticosterone to decrease and T4 to increase after 2 h. These data suggest that PACAP modulates both the endocrine and immune responses in this model of septic shock.
Baranowska-Bik
Agnieszka
A
Neuroendocrinology Department, Medical Centre of Postgraduate Education, Marymoncka 99, 01 - 813 Warsaw, Poland.
Bik
Wojciech
W
Wolinska-Witort
Ewa
E
Chmielowska
Magdalena
M
Martynska
Lidia
L
Baranowska
Boguslawa
B
D000208:Acute Disease; D000818:Animals; D003345:Corticosterone / Q000097:blood; D016207:Cytokines / Q000097:blood; D004703:Endocrine System / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000627:therapeutic use*; D051381:Rats; D011921:Rats, Inbred WKY
D016207:Cytokines; D008070:Lipopolysaccharides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D003345:Corticosterone