Perifosine may be of therapeutic usefulness in morbid obese females via inhibition of the PI3K/Akt signaling pathway.
Geroldi
Diego
D
Aldeghi
Alessia
A
Emanuele
Enzo
E
D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D009767:Obesity, Morbid / Q000188:drug therapy* / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
D010767:Phosphorylcholine; C105905:perifosine; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt