title: Differentiation of spontaneous and induced mammary adenocarcinomas of the rat by gene expression profiling.
abstract: The differentiation of spontaneous and induced adenocarcinomas is of interest in the setting of carcinogenicity studies. In the experiment reported here, a differentiation of morphologically similar spontaneous and induced mammary adenocarcinomas of the rat is achieved by gene expression profiling. By choosing one marker gene based on the gene expression profile for each tumour type, we were able to distinguish the tumours by real-time quantitative polymerase chain reaction (RT-QPCR) as well.
authors.affiliation: Preclinical Safety, Novartis Pharma AG, Basel, Switzerland. heike.marxfeld@eur.crl.com
authors.forename: Heike
authors.initials: H
authors.lastname: Marxfeld
authors.forename: Olivier
authors.initials: O
authors.lastname: Grenet
authors.forename: Josiane
authors.initials: J
authors.lastname: Bringel
authors.forename: Frank
authors.initials: F
authors.lastname: Staedtler
authors.forename: Johannes H
authors.initials: JH
authors.lastname: Harleman
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000235:genetics*; D000818:Animals; D005260:Female; D020869:Gene Expression Profiling; D015674:Mammary Neoplasms, Animal / Q000235:genetics* / Q000473:pathology; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene