[Factors influencing the recurrence of Cushing's disease treated by transsphenoidal surgery].
OBJECTIVE
To explore factors influencing the recurrence of patients with Cushing's disease after transsphenoidal surgery.


METHODS
We retrospectively analyzed the clinical data of 182 patients treated by transsphenoidal surgery with Cushing's disease in our department in PUMC Hospital from 1992 to 2002.


RESULTS
The recurrence rates were significantly different when patients had different radiological findings (P = 0.001), operative methods (P = 0.001), histological findings (P = 0.04), and postoperative cortisol levels (P = 0.02); however, such difference was not found in term of tumor size (P = 0.43).


CONCLUSIONS
Radiological findings, operative methods, histological findings, and postoperative cortisol estimates may be the factors influencing the recurrence of patients treated by transsphenoidal surgery.
Xia
Xue-Wei
XW
Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Su
Chang-Bao
CB
Ren
Zu-Yuan
ZY
Wang
Ren-Zhi
RZ
Yang
Yi
Y
Ma
Wen-Bin
WB
Li
Yong-Ning
YN
Kong
Yan-Guo
YG
D000236:Adenoma / Q000150:complications / Q000601:surgery; D005260:Female; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000209:etiology / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies