Small-cell lung carcinoma of recipient origin after bilateral lung transplantation for cystic fibrosis.
Bronchial carcinoma, usually of the non-small-cell type, is uncommon after lung transplantation and occurs predominantly in single-lung transplant ex-smoker recipients on their native lung. Bronchial carcinoma of donor origin is much rarer. We report the case of a small-cell lung carcinoma of recipient origin that occurred 12 months after a bilateral lung transplantation for cystic fibrosis in a 25-year-old woman who was a non-smoker. The tumor was of recipient origin, due to a gender mismatch between donor and recipient. This unusual observation corroborates the hypothesis of chimerism of the bronchial epithelium after lung transplantation.
Picard
Clément
C
Service pneumologie, Hôpital Foch, Suresnes, France.
Grenet
Dominique
D
Copie-Bergman
Christiane
C
Martin
Nadine
N
Longchampt
Elisabeth
E
Zemoura
Leila
L
Stern
Marc
M
D000328:Adult; D018288:Carcinoma, Small Cell / Q000209:etiology* / Q000473:pathology; D003550:Cystic Fibrosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D016040:Lung Transplantation / Q000009:adverse effects*