title: A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis.
abstract: The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed.
authors.affiliation: Crucell Holland BV, Leiden, The Netherlands. j.dekruif@crucell.com
authors.forename: John
authors.initials: J
authors.lastname: de Kruif
authors.forename: Alexander B H
authors.initials: AB
authors.lastname: Bakker
authors.forename: Wilfred E
authors.initials: WE
authors.lastname: Marissen
authors.forename: R Arjen
authors.initials: RA
authors.lastname: Kramer
authors.forename: Mark
authors.initials: M
authors.lastname: Throsby
authors.forename: Charles E
authors.initials: CE
authors.lastname: Rupprecht
authors.forename: Jaap
authors.initials: J
authors.lastname: Goudsmit
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007136:Immunoglobulins / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use*; D011818:Rabies / Q000517:prevention & control*; D011820:Rabies virus / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007155:Immunologic Factors