title: Postoperative adjuvant treatment for pineal parenchymal tumour of intermediate differentiation.
abstract: Pineal parenchymal tumour of intermediate differentiation (PPTID) in adults is rare and a treatment strategy for this condition has not yet been established. We present a case of an elderly patient treated with postoperative adjuvant therapy using radio- and chemotherapy. This 60-year-old man presented with a 3-month history of memory disturbance, gait instability and double vision. Computed tomography and magnetic resonance imaging demonstrated a mass in the pineal region that suggested a malignant tumour. Partial removal of the tumour was undertaken via the right occipital transtentorial approach. The histological diagnosis was PPTID. Postoperative radio- and chemotherapy were administered, with a good response. Little is known about the clinical behaviour of PPTID in adults. Our treatment plan indicates one effective option for the management of such tumours.
authors.affiliation: Department of Neurosurgery, Oita University, 1-1 Idaigaoka, Hasama, Oita 879 5593, Japan. annmitsu@med.oita-u.ac.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Anan
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ishii
authors.forename: Takaharu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masanori
authors.initials: M
authors.lastname: Yamashita
authors.forename: Seiji
authors.initials: S
authors.lastname: Katayama
authors.forename: Michifumi
authors.initials: M
authors.lastname: Sainoo
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nagatomi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D004172:Diplopia / Q000209:etiology / Q000503:physiopathology; D004358:Drug Therapy / Q000379:methods* / Q000592:standards; D005047:Etoposide / Q000627:therapeutic use; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010870:Pineal Gland / Q000187:drug effects* / Q000528:radiation effects* / Q000601:surgery; D010871:Pinealoma / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D011829:Radiation Dosage; D011878:Radiotherapy / Q000379:methods* / Q000592:standards; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005047:Etoposide; D016190:Carboplatin