Naphthopyrone glucosides from the seeds of Cassia tora with inhibitory activity on advanced glycation end products (AGEs) formation.
Three naphthopyrone glucosides, cassiaside (1), rubrofusarin-6-O-beta-D-gentiobioside (2), and toralactone-9-O-beta-D-gentiobioside (3), were isolated from the BuOH-soluble extract of the seeds of Cassia tora as active constituents, using an in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structures of 1-3 were determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates (1-3) were evaluated for the inhibitory activity on AGEs formation in vitro.
Lee
Ga Young
GY
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.
Jang
Dae Sik
DS
Lee
Yun Mi
YM
Kim
Jong Min
JM
Kim
Jin Sook
JS
D002366:Cassia / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017127:Glycation End Products, Advanced / Q000096:biosynthesis; D006031:Glycosylation; D015394:Molecular Structure; D011499:Protein Processing, Post-Translational; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism
D002867:Chromones; D004187:Disaccharides; D005960:Glucosides; D017127:Glycation End Products, Advanced; D011753:Pyrones; C119595:rubrofusarin gentiobioside; C513232:toralactone-9-O-gentiobioside; C119594:cassiaside; D012710:Serum Albumin, Bovine