A TGF-beta1 polymorphism association with dementia and neuropathologies: the HAAS.
The transforming growth factor-beta1 (TGF-beta1) is involved in post-ischemic neuronal rescue and in beta-amyloid turn-over. We hypothesized that the risk for dementia and related neuropathologies is modified by the TGF-beta1 functional genetic variants. The association of the TGF-beta1+29T-->C polymorphism with dementia was examined in a sample of 261 cases and 491 controls from the Honolulu-Asia Aging Study, including 282 subjects with autopsy data. Dementia was assessed in 1991 and 1994 by a multi-step protocol and standardized diagnostic criteria. The analysis was adjusted for demographic and vascular factors. Compared to the TT genotype, the TC and the CC genotypes were associated with a reduced risk for vascular dementia (OR(TC)=0.28, 95% confidence interval (CI): 0.1-0.9; OR(CC)=0.28, CI: 0.1-0.9), microinfarcts (OR(CC)=0.31, CI: 0.13-0.71) and cerebral amyloid angiopathy (OR(CC)=0.48, CI: 0.2-0.9). The CC genotype was associated with an increase risk of neocortical plaques (OR(CC)=4.34, CI: 1.6-11.8). These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia.
Peila
Rita
R
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C-309, Bethesda, MD 20892-9205, USA. peilar@mail.nih.gov <peilar@mail.nih.gov>
Yucesoy
Berran
B
White
Lon R
LR
Johnson
Victor
V
Kashon
Michael L
ML
Wu
Kim
K
Petrovitch
Helen
H
Luster
Michael
M
Launer
Lenore J
LJ
D000368:Aged; D000369:Aged, 80 and over; D001213:Asian; D001344:Autopsy; D016657:Cerebral Amyloid Angiopathy; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D003704:Dementia / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015577:Geriatric Assessment; D006254:Hawaii / Q000453:epidemiology / Q000208:ethnology; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012720:Severity of Illness Index; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D053773:Transforming Growth Factor beta1