[Optimisation of the conditions of particle sizing of gentamicin sulfate].
One of the problems for the development of dry powder inhalation preparations is evaluation of particle size distribution of obtained micronized powders for the determination of theoretical aerodynamic diameter of the particles. The final aim of our study is the development of inhalation dry powder formulation of gentamicin sulfate, therefore it is necessary to determine theoretical aerodynamic diameter of micronized gentamicin sulfate particles. Micronized gentamicin sulfate powders are very cohesive and do not have satisfactory flow properties, the shape of the particles is close to spherical. The most suitable technique for this kind of powders is laser diffraction. On the basis of realized experiments the optimal conditions for the determination of particle size distribution of gentamicin powders were found. Results are in accordance with the data obtained by method-reference (Electron Microscopy).
Dzhikiia
T Dzh
TD
Bakuridze
A D
AD
Tsagareishvili
N T
NT
Kurdiani
N G
NG
Tsurtsumiia
I G
IG
D000280:Administration, Inhalation; D005839:Gentamicins / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D008904:Miniaturization; D011208:Powders / Q000032:analysis*
D005839:Gentamicins; D011208:Powders