title: Colloidal stability of pluronic F68-coated PLGA nanoparticles: a variety of stabilisation mechanisms.
abstract: Poloxamers are a family of polypropylene oxide (PPO) and polyethylene oxide (PEO) tri-block copolymers that are usually employed in the micro- and nanoparticulate engineering for drug delivery systems. The aim of this work is to study the electrophoretic mobility (mu(e)) and colloidal stability of complexes formed by adsorbing a poloxamer (Pluronic F68) onto poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles. A variety of stabilisation mechanisms have been observed for the Pluronic-coated PLGA nanoparticles, where DLVO interactions, solvent-polymer segment interactions and hydration forces play different roles as a function of the adsorbed amount of Pluronic. In addition, the mu(e) and stability data of these complexes have been compared to those obtained previously using a PLGA-Pluronic F68 blend formulation. As both the mu(e) and the stability data are identical between the two systems, a phase separation of both components in the PLGA-Pluronic blend formulation is suggested, being the PLGA located in the core of the particles and the Pluronic in an adsorbed shell.
authors.affiliation: Biocolloid and Fluid Physics Group, Department of Applied Physics, University of Granada, Av. Fuentenueva S/N, 18071, Granada, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Santander-Ortega
authors.forename: A B
authors.initials: AB
authors.lastname: Jódar-Reyes
authors.forename: N
authors.initials: N
authors.lastname: Csaba
authors.forename: D
authors.initials: D
authors.lastname: Bastos-González
authors.forename: J L
authors.initials: JL
authors.lastname: Ortega-Vinuesa
mesh_terms: D000327:Adsorption; D002122:Calcium Chloride / Q000737:chemistry; D003102:Colloids; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D013499:Surface Properties
chemical_list: D003102:Colloids; D011108:Polymers; D020442:Poloxamer; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012965:Sodium Chloride; D002122:Calcium Chloride