title: Outcomes of donor evaluations for adult-to-adult right hepatic lobe living donor liver transplantation.
abstract: The purpose of this study is to determine the role of liver biopsy and outcome of patients undergoing donor evaluation for adult-to-adult right hepatic lobe living donor liver transplantation (LDLT). Records of patients presenting for a comprehensive donor evaluation between 1997 and February 2005 were reviewed. Liver biopsy was performed only in patients with risk factors for abnormal histology. Two hundred and sixty patients underwent a comprehensive donor evaluation and 116 of 260 (45%) were suitable for donation, 14 of 260 (5.4%) did not complete evaluation and 130 of 260 (50%) were rejected. Four patients underwent unsuccessful hepatectomy surgery due to discovery of intraoperative abnormalities. Between 1997 and 2001, the acceptance rate of donor candidates (63%) was higher than 2002-2005 (36%), p < 0.0001. Sixty-six of the 150 eligible patients (44%) fulfilled criteria for liver biopsy and 28 of 66 (42%) had an abnormal finding. Less than half of the patients undergoing donor evaluation were suitable donors and the donor acceptance rate has declined over time. A large proportion of the patients undergoing liver biopsy have abnormal findings. Our evaluation process failed to identify 4 of 103 who had aborted donor surgeries.
authors.affiliation: Division of Gastroenterology/Hepatology, University of Colorado Health Sciences Center, Denver, USA. james.trotter@uchsc.edu
authors.forename: J F
authors.initials: JF
authors.lastname: Trotter
authors.forename: J
authors.initials: J
authors.lastname: Campsen
authors.forename: T
authors.initials: T
authors.lastname: Bak
authors.forename: M
authors.initials: M
authors.lastname: Wachs
authors.forename: L
authors.initials: L
authors.lastname: Forman
authors.forename: G
authors.initials: G
authors.lastname: Everson
authors.forename: I
authors.initials: I
authors.lastname: Kam
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D046148:Donor Selection / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000706:statistics & numerical data; D019520:Living Donors / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome