[The role of neutrophils during allograft rejection].
Because rejection of allografts is primarily caused by T and B lymphocyte responses to allogeneic histocompatibility molecules, the role of innate immunity in organ transplant rejection is often overlooked. However, the very first damages to vascularized organ allografts are caused by ischemia-reperfusion, an inflammatory reaction involving activation of vascular endothelial cells and release of neutrophil chemoattractants. Herein, we review experimental observations suggesting that the early neutrophil influx in organ transplants favors T cell-mediated rejection.
Surquin
Murielle
M
Département de néphrologie, dialyse et transplantation, hôpital Erasme, université Libre de Bruxelles, 808 route de Lennik, 1070 Brussels, Belgium. msurquin@ulb.ac.be
Buonocore
Sofia
S
Le Moine
Alain
A
Flamand
Véronique
V
Goldman
Michel
M
Abramowicz
Daniel
D
D000818:Animals; D006084:Graft Rejection; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D016377:Organ Transplantation; D014184:Transplantation, Homologous