Rhabdomyolysis in the military: recognizing late-onset very long-chain acyl Co-A dehydrogenase deficiency.
Very long-chain acyl Co-A dehydrogenase deficiency, an inborn error of lipid metabolism, is commonly thought of as a disease of infancy or early childhood. However, several cases of late-onset very long-chain acyl Co-A dehydrogenase have been reported. This report of two military men who survived basic training before their disease presentation broadens the spectrum of late-onset disease, presents two previously unreported mutations, and demonstrates the fine line between athletic, active lifestyle and severe disease presentation.
Hoffman
Jodi D
JD
Division of Genetics, Tufts-New England Medical Center, Boston, MA 02111, USA.
Steiner
Robert D
RD
Paradise
Lori
L
Harding
Carey O
CO
Ding
Li
L
Strauss
Arnold W
AW
Kaplan
Paige
P
D044942:Acyl-CoA Dehydrogenase, Long-Chain / Q000172:deficiency*; D000328:Adult; D017668:Age of Onset; D006801:Humans; D008019:Life Style; D008297:Male; D008661:Metabolism, Inborn Errors / Q000150:complications / Q000175:diagnosis*; D008889:Military Personnel; D010809:Physical Fitness; D012206:Rhabdomyolysis / Q000175:diagnosis*
D044942:Acyl-CoA Dehydrogenase, Long-Chain