title: N-Hydroxy and N-acyloxy peptides: synthesis and chemical modifications.
abstract: The preparation of a series of N-hydroxy peptides is described, along with their acylation on the oxygen of the pseudopeptide bond. Nineteen N-acyloxy peptides, first examples of this new class of pseudopeptides, were thus synthesized; they present a range of acyl groups, including N-protected amino acyl groups. Possibilities of elongation for these pseudopeptides were also investigated.
authors.affiliation: Grenoble Universités, LEDSS, UMR CNRS/UJF 5616, ICMG, FR-2607, Université Joseph Fourier Grenoble I, BP 53, 38041, Grenoble Cedex 9, France.
authors.forename: James
authors.initials: J
authors.lastname: Lawrence
authors.forename: Laure
authors.initials: L
authors.lastname: Cointeaux
authors.forename: Pascal
authors.initials: P
authors.lastname: Maire
authors.forename: Yannick
authors.initials: Y
authors.lastname: Vallée
authors.forename: Véronique
authors.initials: V
authors.lastname: Blandin
mesh_terms: D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation
chemical_list: D010455:Peptides