Polyhexamethylenebiguanide hydrochloride exposure and erythema multiforme in a physician.
A 52-year-old woman physician developed recurrent erythema multiforme. Occupational and environmental exposure assessment suggested a disinfectant containing polyhexamethylenebiguanide hydrochloride (PHMB), Phagosept. Elimination of the product was followed by disappearance of symptomatology. Literature search revealed cases of sensitization and anaphylaxis due to contact with PHMB, but to our knowledge, this is the first report on PHMB-induced erythema multiforme.
Gehanno
Jean-François
JF
Department of Occupational Medicine, Rouen University Hospital Charles Nicolle, Rouen, France.
Priot
Anne-Emmanuelle
AE
Balguerie
Xavier
X
Caillard
Jean-François
JF
D001645:Biguanides / Q000009:adverse effects*; D004892:Erythema Multiforme / Q000503:physiopathology*; D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure; D010820:Physicians
D001645:Biguanides; C031233:polihexanide