title: Guaijaverin -- a plant flavonoid as potential antiplaque agent against Streptococcus mutans.
abstract: OBJECTIVE
  The aim of the present study was to investigate the anti-Streptococcus mutans activity and the in vitro effects of subminimal inhibitory concentrations of guaijaverin isolated from Psidium guajava Linn. on cariogenic properties of Strep. mutans.
  
  
  RESULTS
  Bioautography-directed chromatographic fractionation, yield biologically active compound, quercetin-3-O-alpha-l-arabinopyranoside (guaijaverin), from crude methanol extract of P. guajava. Growth-inhibitory activity of the compound against Strep. mutans of both clinical and type strain cultures was evaluated. The anti-Strep. mutans activity of the guaijaverin was found to be bacteriostatic, both heat and acid stable and alkali labile with the minimum inhibitory concentration (MIC) of 4 mg ml(-1) for MTCC 1943 and 2 mg ml(-1) for CLSM 001. The sub-MIC concentrations (0.0078-2 mg ml(-1)) of the guaijaverin were evaluated for its cariogenic properties such as acid production, cell-surface hydrophobicity, sucrose-dependent adherence to glass surface and sucrose-induced aggregation of Strep. mutans.
  
  
  CONCLUSIONS
  The active flavonoid compound, quercetin-3-O-alpha-l-arabinopyranoside (guaijaverin) demonstrated high potential antiplaque agent by inhibiting the growth of the Strep. mutans.
  
  
  CONCLUSIONS
  This study demonstrated the new growth-inhibitory compound guaijaverin against Strep. mutans and led to the acceptance of traditional medicine and natural products as an alternative form of health care.
authors.affiliation: CHORD, Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, India.
authors.forename: G R
authors.initials: GR
authors.lastname: Prabu
authors.forename: A
authors.initials: A
authors.lastname: Gnanamani
authors.forename: S
authors.initials: S
authors.lastname: Sadulla
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control*; D006027:Glycosides / Q000302:isolation & purification / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D031647:Psidium; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D013295:Streptococcus mutans / Q000187:drug effects*; D013395:Sucrose / Q000494:pharmacology
chemical_list: D006027:Glycosides; D010936:Plant Extracts; C088178:guajavarin; D013395:Sucrose; D011794:Quercetin