Synthesis and immunosuppressive activity of new artemisinin derivatives. Part 2: 2-[12(beta or alpha)-dihydroartemisinoxymethyl(or 1'-ethyl)]phenoxyl propionic acids and esters.
Another series of novel dihydroartemisinin derivatives were synthesized and assessed for their cytotoxicity of lymphocyte, inhibitory activity on mitogen-induced spleen lymphocyte proliferation in vitro. Some of the compounds exhibited inhibitory effects on ConA-induced T cell and LPS-induced B cell proliferation comparable to or more potent than parent artemisinin.
Yang
Zhong-Shun
ZS
Department of Synthetic Chemistry, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
Wang
Jun-Xia
JX
Zhou
Yu
Y
Zuo
Jian-Ping
JP
Li
Ying
Y
D037621:Artemisinins / Q000138:chemical synthesis* / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004952:Esters; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D011422:Propionates / Q000138:chemical synthesis / Q000494:pharmacology; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology
D037621:Artemisinins; D004952:Esters; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D011422:Propionates; D012717:Sesquiterpenes; D003208:Concanavalin A; C031327:artemisinin