title: [Factors influencing the recurrence of Cushing's disease treated by transsphenoidal surgery].
abstract: OBJECTIVE
  To explore factors influencing the recurrence of patients with Cushing's disease after transsphenoidal surgery.
  
  
  METHODS
  We retrospectively analyzed the clinical data of 182 patients treated by transsphenoidal surgery with Cushing's disease in our department in PUMC Hospital from 1992 to 2002.
  
  
  RESULTS
  The recurrence rates were significantly different when patients had different radiological findings (P = 0.001), operative methods (P = 0.001), histological findings (P = 0.04), and postoperative cortisol levels (P = 0.02); however, such difference was not found in term of tumor size (P = 0.43).
  
  
  CONCLUSIONS
  Radiological findings, operative methods, histological findings, and postoperative cortisol estimates may be the factors influencing the recurrence of patients treated by transsphenoidal surgery.
authors.affiliation: Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Xia
authors.forename: Chang-Bao
authors.initials: CB
authors.lastname: Su
authors.forename: Zu-Yuan
authors.initials: ZY
authors.lastname: Ren
authors.forename: Ren-Zhi
authors.initials: RZ
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Ma
authors.forename: Yong-Ning
authors.initials: YN
authors.lastname: Li
authors.forename: Yan-Guo
authors.initials: YG
authors.lastname: Kong
mesh_terms: D000236:Adenoma / Q000150:complications / Q000601:surgery; D005260:Female; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000209:etiology / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies