Humoral response in hamsters following vaccination with cDNA encoding acey-1 cysteine proteinase of Ancylostoma ceylanicum.
The humoral response in hamsters following vaccination against Ancylostoma ceylanicum infections with DNA construct was investigated. Groups of hamsters were injected intramuscularly with plasmid pcDNA 3.1. containing cDNA of ACEY-1 cysteine proteinase. Vaccination resulted in IgG antibody response to somatic extracts of adult A. ceylanicum. The highest level of antibodies was observed seven weeks after vaccination.
Mieszczanek
J
J
Parasitology Department, Warsaw Agricultural University, 03-849 Warszawa, Grochowska 272.
Swiderska
M
M
Wedrychowicz
H
H
D000722:Ancylostoma / Q000201:enzymology*; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D000947:Antigens, Helminth / Q000302:isolation & purification; D006224:Cricetinae; D003546:Cysteine Endopeptidases / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D018076:DNA, Complementary / Q000008:administration & dosage*; D018509:DNA, Helminth / Q000008:administration & dosage*; D007114:Immunization / Q000379:methods; D007074:Immunoglobulin G / Q000097:blood; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D018076:DNA, Complementary; D018509:DNA, Helminth; D007074:Immunoglobulin G; D019444:Vaccines, DNA; D003546:Cysteine Endopeptidases