Prenylated xanthones as potential antiplasmodial substances.
Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed.
Mahabusarakam
Wilawan
W
Department of Chemistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand. wilawan.m@psu.ac.th
Kuaha
Kunnika
K
Wilairat
Prapon
P
Taylor
Walter C
WC
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D029762:Garcinia mangostana / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
D000962:Antimalarials; D044004:Xanthones; C021053:mangostin