title: Fine needle aspiration biopsy of vertebral and paravertebral lesions: retrospective study of 124 cases.
abstract: OBJECTIVE
  To evaluate the diagnostic value of image-guided fine needle aspiration biopsy (FNAB) in the diagnosis and management of vertebral and paravertebral lesions and to review similar studies in the literature.
  
  
  METHODS
  One hundred twenty-four FNAB cases (113 [corrected] patients) of vertebral and paravertebral lesions occurring over a 10-year period were retrieved from the archives of the University of Mississippi Medical Center for review and clinico-radiologic correlation. Thirty-four of the cases included a concurrent core needle biopsy sample, 15 cases had subsequent surgical specimens, while 32 cases had previously established malignancy. The age range was 11 days to 91 years (mean, 46 years), with 57 male patients and 56 female.
  
  
  RESULTS
  One hundred five cases were vertebral lesions, and 19 cases were paravertebral lesions. FNAB diagnosis were malignant in 33.87% of cases, benign in 5.64%, suspicious in 4.03%, infectious/inflammatory and degenerative in 12.91%, unsatisfactory in 16.13% and negative in 27.42%. The overall sensitivity of the procedure was 89.3% and the specificity, 93.8%. The positive predictive value was 95.7% and negative predictive value, 85.2%.
  
  
  CONCLUSIONS
  FNAB is an effective means of establishing a definitive diagnosis of vertebral and paravertebral lesions, allowing appropriate patient management. Cell blocks, core biopsies and ancillary studies are useful adjuncts in rendering the diagnosis.
authors.affiliation: Department of Pathology, School of Health Related Professions, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA. israha@hotmail.com
authors.forename: Israh
authors.initials: I
authors.lastname: Akhtar
authors.forename: Rhyne
authors.initials: R
authors.lastname: Flowers
authors.forename: Anwer
authors.initials: A
authors.lastname: Siddiqi
authors.forename: Ken
authors.initials: K
authors.lastname: Heard
authors.forename: Mithra
authors.initials: M
authors.lastname: Baliga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000473:pathology; D044963:Biopsy, Fine-Needle; D001759:Blastomycosis / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology; D012189:Retrospective Studies; D013122:Spinal Diseases / Q000175:diagnosis / Q000473:pathology*; D013131:Spine / Q000473:pathology*