title: Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues.
abstract: Two series of dioscin derivatives (4a-o and 5a-o) with selected modifications at the 6' and 4''' positions of the chacotriosyl residue, respectively, were synthesized. All the 6'-N-acyl-dioscin derivatives did not show considerable inhibitory activities at 10 microM, while most of the 4'''-O-(2-N-acyl)ethyl-dioscin derivatives behaved as potent as dioscin, against the growth of tumor cells.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Shilei
authors.initials: S
authors.lastname: Zhu
authors.forename: Yichun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: Yu
authors.forename: Lihong
authors.initials: L
authors.lastname: Zhang
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Li
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D045744:Cell Line, Tumor; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D014326:Tropanes / Q000737:chemistry*
chemical_list: D014326:Tropanes; C433845:chacotriose; C019357:dioscin; D004144:Diosgenin