title: [Enteropathy-type T-cell lymphoma with CD8 and CD56 expression].
abstract: A 54-year-old male presented at a previous hospital with abdominal pain, where the patient was diagnosed as having abdominal and retroperitoneal lymphadenopathies by CT scan, then, he was referred to our hospital for further examination. Upper gastrointestinal endoscopy showed a tumor formation in the second portion of the duodenum, and there were medium sized atypical lymphocytes in biopsy specimens of the tumor. Since the atypical lymphocytes in the biopsy specimens were positive for CD3, CD8, CD56 and CD103 by immunostain, and had a rearrangement of the T-cell receptor 7-chain, the patient was diagnosed as having enteropathy-type T-cell lymphoma (ETL). Although ETL usually occurs as a complication of celiac disease, malabsorption and anti-gliadin antibodies, which are normally present in celiac disease, were not observed in this patient.
authors.affiliation: Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sakai
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sato
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobune
authors.forename: Rishu
authors.initials: R
authors.lastname: Takimoto
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D017252:CD3 Complex / Q000096:biosynthesis; D019002:CD56 Antigen / Q000096:biosynthesis*; D016827:CD8 Antigens / Q000096:biosynthesis*; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D016099:Endoscopy, Gastrointestinal; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D017252:CD3 Complex; D019002:CD56 Antigen; D016827:CD8 Antigens