title: Asymmetric multicomponent [C+NC+CC] synthesis of highly functionalized pyrrolidines catalyzed by silver(I).
abstract: [reaction: see text] Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective Ag(I)-catalyzed asymmetric [C+NC+CC] coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines for both target- and diversity-oriented syntheses.
authors.affiliation: Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, USA. ppg@case.edu
authors.forename: Philip
authors.initials: P
authors.lastname: Garner
authors.forename: H Umit
authors.initials: HU
authors.lastname: Kaniskan
authors.forename: Jieyu
authors.initials: J
authors.lastname: Hu
authors.forename: Wiley J
authors.initials: WJ
authors.lastname: Youngs
authors.forename: Matthew
authors.initials: M
authors.lastname: Panzner