title: Brassicaceae contain nortropane alkaloids.
abstract: The report of cochlearine, the 3-hydroxybenzoate ester of tropine found in Cochlearia officinalis, Brassicaceae, initiated a screening for tropane alkaloids in Cochlearia species and for calystegines in further Brassicaceae. All ten Cochlearia species investigated contained cochlearine, tropine, and pseudotropine. Calystegines, nortropane alkaloids deriving from pseudotropine, were also identified in all Cochlearia species and accumulated up to 0.5% dry mass in leaves. Brassicaceae species of all major lineages of the family were analysed for calystegines. Of the 43 species included in the study, 18 accumulated calystegines of various structures. This is the first screening of Brassicaceae for products of the tropane alkaloid pathway, which is known as characteristic for plants of Solanaceae family. The identification of calystegines in all branches of the Brassicaceae family including Aethionema, a species at the basis of the family, suggests tropane alkaloids as secondary compound typical for Brassicaceae.
authors.affiliation: Institute of Pharmaceutical Biology and Pharmacology, Faculty of Pharmacy, Martin Luther University Halle-Wittenberg, Hoher Weg 8, D-06120-Halle, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Brock
authors.forename: Tobias
authors.initials: T
authors.lastname: Herzfeld
authors.forename: Reinhard
authors.initials: R
authors.lastname: Paschke
authors.forename: Marcus
authors.initials: M
authors.lastname: Koch
authors.forename: Birgit
authors.initials: B
authors.lastname: Dräger
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D019607:Brassicaceae / Q000737:chemistry* / Q000145:classification*; D009662:Nortropanes / Q000737:chemistry* / Q000302:isolation & purification; D012991:Solanaceous Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D014326:Tropanes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D009662:Nortropanes; D012991:Solanaceous Alkaloids; D014326:Tropanes; C516710:cochlearine; C095613:calystegine B(2)