title: [Hypersensitivity reactions to multiple drugs during the course of hairy cell leukemia treated with 2-chlorodeoxyadenosine].
abstract: A 38-year-man developed diffuse erythema 3 days after the administration of 2-chlorodeoxyadenosine (cladribine or 2-CdA) and many other drugs for hairy cell leukemia (HCL). Patch-testing and scratch patch-testing showed positive reactions for clindamycin (10%, 30%) at 24 hours and 48 hours. Furthermore, provocation-testing showed positive reactions for sulfamethoxazole.trimethoprim, allopurinol, fluconazole, so our diagnosis was erythroderma-type drug eruption due to clindamycin, sulfamethoxazole-trimethoprim, allopurinol, fluconazole. Cutaneous side-effects associated with cladribine have seldom been described in cases of HCL. Our case suggests that there is a relationship between the drug hypersensitivity and the prolonged suppressed CD4 cell levels caused by cladribine.
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Osaka University. karakara@hbk.pref.osaka.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Kokunai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Azusawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Murota
authors.forename: Chika
authors.initials: C
authors.lastname: Ohhata
authors.forename: Ichiro
authors.initials: I
authors.lastname: Katayama
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Murata
authors.forename: Seiji
authors.initials: S
authors.lastname: Tadokoro
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017338:Cladribine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy*; D008297:Male
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine