title: Serum cytokines and bone metabolism in patients with thyroid dysfunction.
abstract: Hyperthyroidism is associated with increased bone turnover. Besides the hormones of calcium metabolism, locally produced factors are important in maintaining normal bone metabolism. Interleukin-6 (IL-6), in particular, has a major influence on bone turnover. In this study, serum IL-6 and tumor necrosis factor-alpha (TNF-alpha) levels, as well as bone turnover markers and relationships between them, were investigated in hyperthyroidism and hypothyroidism. A total of 20 female patients with hyperthyroidism, 15 with subclinical hyperthyroidism, 16 with hypothyroidism, and 15 with subclinical hypothyroidism constituted the patient groups. In all, 15 age-matched healthy female volunteers were recruited as controls. When compared with controls, serum TNF-alpha levels showed no significant difference in any of the patient groups (P>.05). In the groups with hyperthyroidism and subclinical hyperthyroidism, IL-6 levels were significantly higher compared with control group values (P<.05). Hyperthyroid patients showed higher levels of alkaline phosphatase (ALP) and osteocalcin, and a higher urinary deoxypyridinoline/creatinine ratio, compared with controls (P<.05). In subclinical hyperthyroidism, only ALP was found to be higher compared with control values. No significant correlations were made in any group between serum IL-6 or TNF-alpha level and bone turnover markers. Results suggest that serum IL-6 level and markers of bone turnover rate seem to be increased in hyperthyroidism. This finding may support the role of IL-6 in induction of bone turnover in hyperthyroid states.
authors.affiliation: Department of Biochemistry, Yüzüncü Yil University, Van, Turkey.
authors.forename: M Ramazan
authors.initials: MR
authors.lastname: Sekeroglu
authors.forename: Z Büsra
authors.initials: ZB
authors.lastname: Altun
authors.forename: Ekrem
authors.initials: E
authors.lastname: Algün
authors.forename: Haluk
authors.initials: H
authors.lastname: Dülger
authors.forename: Tevfik
authors.initials: T
authors.lastname: Noyan
authors.forename: Ragip
authors.initials: R
authors.lastname: Balaharoglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oztürk
mesh_terms: D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D015850:Interleukin-6 / Q000096:biosynthesis*; D013960:Thyroid Function Tests; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002118:Calcium