title: Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death.
abstract: BACKGROUND
  Guidelines for optimal weight in older persons are limited by uncertainty about the ideal body mass index (BMI) or the usefulness of alternative anthropometric measures.
  
  
  OBJECTIVE
  We investigated the association of BMI (in kg/m(2)), waist circumference, and waist-hip ratio (WHR) with mortality and cause-specific mortality.
  
  
  METHODS
  Subjects aged >/=75 y (n = 14 833) from 53 family practices in the United Kingdom underwent a health assessment that included measurement of BMI and waist and hip circumferences; they also were followed up for mortality.
  
  
  RESULTS
  During a median follow-up of 5.9 y, 6649 subjects died (46% of circulatory causes). In nonsmoking men and women (90% of the cohort), compared with the lowest quintile of BMI (<23 in men and <22.3 in women), adjusted hazard ratios (HRs) for mortality were <1 for all other quintiles of BMI (P for trend = 0.0003 and 0.0001 in men and women, respectively). Increasing WHR was associated with increasing HRs in men and women (P for trend = 0.008 and 0.0002, respectively). BMI was not associated with circulatory mortality in men (P for trend = 0.667) and was negatively associated in women (P for trend = 0.004). WHR was positively related to circulatory mortality in both men and women (P for trend = 0.001 and 0.005, respectively). Waist circumference was not associated with all-cause or circulatory mortality.
  
  
  CONCLUSIONS
  Current guidelines for BMI-based risk categories overestimate risks due to excess weight in persons aged >/=75 y. Increased mortality risk is more clearly indicated for relative abdominal obesity as measured by high WHR.
authors.affiliation: Centre for Ageing and Public Health and the Nutrition and Public Health Interventions Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Gill M
authors.initials: GM
authors.lastname: Price
authors.forename: Ricardo
authors.initials: R
authors.lastname: Uauy
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Breeze
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bulpitt
authors.forename: Astrid E
authors.initials: AE
authors.lastname: Fletcher
mesh_terms: D000368:Aged; D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002318:Cardiovascular Diseases / Q000401:mortality; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000401:mortality; D009765:Obesity / Q000401:mortality*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012140:Respiratory Tract Diseases / Q000401:mortality; D012307:Risk Factors; D012907:Smoking; D006113:United Kingdom / Q000453:epidemiology; D049629:Waist-Hip Ratio