title: The influences of a nitrogen atom position in dinucleoside 2-,3-,4-pyridylphosphonates on fragmentation patterns in electrospray ionization multistage tandem mass spectra.
abstract: 2-,3-,4-Pyridylphosphonates and their phosphonothioate congeners were analyzed by electrospray ionization multistage tandem mass spectrometry (ESI-MS(n)). It was found that the fragmentation pathways of these compounds were not influenced to any detectable extent by the stereochemistry at the phosphorus centers but were sensitive to the position of a nitrogen atom in the pyridine ring of these compounds. Possible mechanisms for fragmentations of the investigated compounds are discussed in detail.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.
authors.forename: Sanhao
authors.initials: S
authors.lastname: Ji
authors.forename: Yong
authors.initials: Y
authors.lastname: Ju
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
authors.forename: Tommy
authors.initials: T
authors.lastname: Johansson
authors.forename: Jacek
authors.initials: J
authors.lastname: Stawinski
mesh_terms: D019281:Dimerization; D008968:Molecular Conformation; D009584:Nitrogen / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D009705:Nucleosides; D009943:Organophosphorus Compounds; D009584:Nitrogen