title: Vanadium-catalyzed addition of propargyl alcohols and imines.
abstract: A Mannich-type addition of propargylic alcohols and N-methoxycarbonylimines has been achieved by using a vanadium catalyst. The reactivity of the vanadium catalyst could be modulated by modifying the silanol ligands to avoid the background reaction. The strategy described herein provides an atom-economical access to beta-aryl-substituted Z-enones with an allylic amino functional group, which are not readily accessible with other methods.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Cheol K
authors.initials: CK
authors.lastname: Chung
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D014639:Vanadium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007097:Imines; D020005:Propanols; D014639:Vanadium; C028255:propargyl alcohol