The effect of type 2 diabetes on diastolic function.
OBJECTIVE
This study aimed to determine whether sedentary overweight subjects with type 2 diabetes have impaired diastolic function compared with equally sedentary and overweight nondiabetic subjects.


METHODS
Mitral valve pulsed Doppler echocardiography and tissue Doppler imaging (TDI) were used to assess left ventricular structure and diastolic function in 40- to 60-yr-old sedentary overweight subjects with type 2 diabetes (N = 13) and age- and body mass-matched sedentary nondiabetic subjects (N = 15). Pseudonormal filling was identified using preload reduction and TDI.


RESULTS
Traditional Doppler mitral inflow parameters were not different between groups; however, early diastolic relaxation, as measured by peak early mitral annular velocity (E') and the ratio of E' and peak late mitral annular velocity (E'/A'), was reduced in type 2 diabetic subjects (P < 0.05). The ratio of peak early mitral inflow (E) to E' (E/E'), an estimate of left ventricular filling pressure, was also higher in the type 2 diabetes group (P < 0.05). The proportions of diastolic impairment (69 vs 40%) and pseudonormal filling (39 vs 20%) were not different between groups (P = 0.18).


CONCLUSIONS
These findings suggest that type 2 diabetes has an effect on diastolic function that is independent of age and body composition.
Baldi
James C
JC
Department of Sport and Exercise Science, The University of Auckland, Auckland, New Zealand. j.baldi@auckland.ac.nz
Aoina
James L
JL
Whalley
Gillian A
GA
Carrick-Ranson
Graeme
G
Walsh
Helen A
HA
O'Shaughnessy
Helen
H
Bagg
Warwick
W
Doughty
Robert N
RN
D000328:Adult; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology*; D018619:Echocardiography, Doppler, Pulsed; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight; D010101:Oxygen Consumption / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*