title: Phosphodiesterase-I inhibitor quinovic acid glycosides from Bridelia ndellensis.
abstract: Quinovic acid-3-O-alpha-L-rhamnopyranoside (1), quinovic acid-3-O-beta-D-fucopyranoside (2), quinovic acid-3-O-beta-D-glucopyranosyl (1 --> 4)-beta-D-fucopyranoside (3), methyl gallate (4) and ethyl gallate (5) were isolated from the ethyl acetate extract of Bridelia ndellensis barks by fractionation. Compounds 1-3 showed significant inhibitory activity against snake venom phosphodiesterase-I.
authors.affiliation: Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.
authors.forename: M
authors.initials: M
authors.lastname: Mostafa
authors.forename: Nilufar
authors.initials: N
authors.lastname: Nahar
authors.forename: M
authors.initials: M
authors.lastname: Mosihuzzaman
authors.forename: Selestin D
authors.initials: SD
authors.lastname: Sokeng
authors.forename: Naheed
authors.initials: N
authors.lastname: Fatima
authors.lastname: Atta-Ur-Rahman
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D019665:Euphorbiaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D043264:Phosphodiesterase I / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D010726:Phosphodiesterase Inhibitors; D012503:Saponins; D014315:Triterpenes; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom