Effects of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide on food intake and locomotor activity in the goldfish, Carassius auratus.
We investigated the effects of intracerebroventricular (ICV) and intraperitoneal (IP) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on food intake in the goldfish, Carassius auratus. Cumulative food intake was significantly decreased by ICV injection of PACAP or VIP. Similarly, IP administration of PACAP or VIP induced a significant decrease in food intake. ICV injection of PACAP or VIP also induced a significant decrease in locomotor activity. These results suggest that PACAP and VIP may be involved in the regulation of feeding in goldfish.
Matsuda
Kouhei
K
Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama 930-8555, Japan. kmatsuda@sci.u-toyama.ac.jp
Maruyama
Keisuke
K
Nakamachi
Tomoya
T
Miura
Tohru
T
Shioda
Seiji
S
D000818:Animals; D004435:Eating / Q000187:drug effects*; D006054:Goldfish; D009043:Motor Activity / Q000187:drug effects*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000494:pharmacology*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D014660:Vasoactive Intestinal Peptide