title: Changes in bleeding patterns with depot medroxyprogesterone acetate subcutaneous injection 104 mg.
abstract: OBJECTIVE
  This study aims to assess changes in bleeding patterns with the use of depot medroxyprogesterone acetate (DMPA) 104 mg/0.65 ml subcutaneous injection (DMPA-SC 104).
  
  
  METHODS
  An analysis was conducted using data from two 1-year, noncomparative clinical trials (N=1787) and a 2-year randomized study comparing DMPA-SC 104 (N=266) with DMPA intramuscular injection (DMPA-IM). Bleeding was analyzed per 30-day interval by category and number of days. Analyses also were performed for age and body mass index (BMI) subgroups and for the percentages of women shifting from bleeding/spotting to amenorrhea after each injection.
  
  
  RESULTS
  Each study showed decreased incidence of irregular bleeding and increased amenorrhea with continued use of DMPA-SC 104. Rates of amenorrhea at Month 12 (52-64% across studies) and Month 24 (71% in the 2-year trial) were comparable with those originally reported for DMPA-IM. Changes in bleeding patterns showed no consistent differences according to age or BMI. The percentages of subjects shifting from bleeding and/or spotting to amenorrhea increased with each subsequent injection.
  
  
  CONCLUSIONS
  Clinical data show that the incidence of amenorrhea increases over time with the use of DMPA-SC 104.
authors.affiliation: Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. rarias@hsc.usc.edu
authors.forename: Raquel D
authors.initials: RD
authors.lastname: Arias
authors.forename: John K
authors.initials: JK
authors.lastname: Jain
authors.forename: Cosima
authors.initials: C
authors.lastname: Brucker
authors.forename: Doug
authors.initials: D
authors.lastname: Ross
authors.forename: Amrit
authors.initials: A
authors.lastname: Ray
mesh_terms: D000328:Adult; D000568:Amenorrhea; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage*; D008597:Menstrual Cycle / Q000187:drug effects*; D014592:Uterine Hemorrhage
chemical_list: D003692:Delayed-Action Preparations; D017258:Medroxyprogesterone Acetate