title: A novel saliva test for caries risk assessment.
abstract: A new saliva test for caries risk assessment introduced in this study integrates a variety of host factors to predict for children, individual risk levels that are tooth-group specific. These various host factors correlate with caries history, DFT (decayed and filled teeth) or DFS (decayed and filled surfaces) in young adults. The test is based on the pattern of genetically determined oligosaccharides present on salivary glycoproteins. The mechanism behind the test is believed to be centered on the specific oligosaccharides that either facilitate bacterial attachment and colonization at the surface of teeth or protect against colonization by promoting agglutination and removal of free bacteria. It is the ratio of the two classes of oligosaccharides that is very strongly correlated with the numerical range of DFS or DFT observed in a young adult population.
authors.affiliation: Division of Diagnostic Sciences, University of Southern California School of Dentistry, Los Angeles 90089, USA.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Denny
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Denny
authors.forename: Jona
authors.initials: J
authors.lastname: Takashima
authors.forename: Yan
authors.initials: Y
authors.lastname: Si
authors.forename: Mahvash
authors.initials: M
authors.lastname: Navazesh
authors.forename: Joyce M
authors.initials: JM
authors.lastname: Galligan
mesh_terms: D000328:Adult; D002648:Child; D003731:Dental Caries / Q000175:diagnosis*; D003733:Dental Caries Susceptibility; D004812:Epidemiologic Methods; D006801:Humans; D037102:Lectins; D009844:Oligosaccharides / Q000032:analysis*; D012463:Saliva / Q000737:chemistry*
chemical_list: D037102:Lectins; D009844:Oligosaccharides