title: Assessment with magnetic resonance imaging and spectroscopy in Lhermitte-Duclos disease.
abstract: Lhermitte-Duclos disease (LDD) is a rare benign lesion of uncertain pathogenesis characterized by distortion of the normal cerebellar laminar cytoarchitecture. We report a 22-year-old man admitted for injury sustained in a traffic accident with the incidental finding of a cerebellar mass. Magnetic resonance imaging (MRI) revealed a mass lesion within the right cerebellar hemisphere. The final diagnosis of LDD was made by obtaining a surgical specimen and identifying the characteristic appearance of the lesion by MRI study. The images showed the typical striated pattern of hyperintensity on T2-weighted images and corresponding hypointensity on T1-weighted images, as well as the typical absence of enhancement following gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) administration. In addition, no disturbance of water diffusion on diffusion-weighted MRI, and associations of decreases in the N-acetylaspartate/creatine (NAA/Cr) and NAA/Choline (Cho) ratios with near normal values of Cho/Cr, as well as an obvious lactate peak gave supplemental information for diagnosis.
authors.affiliation: Department of Radiology, Taichung Veterans General Hospital, Taiwan, ROC. chenhaowu@mail.vghtc.gov.tw
authors.forename: Chen-Hao
authors.initials: CH
authors.lastname: Wu
authors.forename: Jyh-Wen
authors.initials: JW
authors.lastname: Chai
authors.forename: Chen-Hui
authors.initials: CH
authors.lastname: Lee
authors.forename: Wen-Hsien
authors.initials: WH
authors.lastname: Chen
authors.forename: Tan
authors.initials: T
authors.lastname: Lee
authors.forename: Clayton Chi-Cheng
authors.initials: CC
authors.lastname: Chen
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D002528:Cerebellar Neoplasms / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005729:Ganglioneuroma / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline