title: Modulation of pituitary adenylate cyclase-activating polypeptide (PACAP) expression in explant-cultured guinea pig cardiac neurons.
abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) expression was quantified in explant-cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP-immunoreactive neurons and pro-PACAP transcript levels increased significantly. Treatment with neurturin or glial-derived neurotrophic factor significantly suppressed the percentage of PACAP-IR neurons, but not pro-PACAP transcript levels.
authors.affiliation: University of Vermont College of Medicine, Department of Anatomy & Neurobiology, 149 Beaumont Avenue, HSRF 416A, Burlington, VT 05405, USA. Beatrice.Girard@uvm.edu
authors.forename: Beatrice M
authors.initials: BM
authors.lastname: Girard
authors.forename: Beth A
authors.initials: BA
authors.lastname: Young
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Buttolph
authors.forename: Sheryl L
authors.initials: SL
authors.lastname: White
authors.forename: Rodney L
authors.initials: RL
authors.lastname: Parsons
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D005260:Female; D005786:Gene Expression Regulation; D006168:Guinea Pigs; D008297:Male; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000235:genetics / Q000378:metabolism*
chemical_list: D051219:Pituitary Adenylate Cyclase-Activating Polypeptide