Chronic mucocutaneous candidiasis associated with malignant thymoma and systemic lupus erythematosus with hypergammaglobulinemia: a case report and literature review.
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent candidal infections of the mucous membranes, nails, and skin. Systemic involvement is rare. CMC in adults with coexistent thymoma, benign or malignant, is well-known and is often associated with hypogammaglobulinemia. There is an unusually high frequency of thymoma and systemic lupus erythematosus (SLE). I present a case of a patient with a history of malignant thymoma, SLE, and hypergammaglobulinemia who was found to have CMC. Discussion of the relationship of these findings is presented.
San Filippo
James
J
Department of Dermatology, State University of New York at Buffalo, USA. js@neoucom.edu
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D017964:Itraconazole / Q000627:therapeutic use; D007654:Ketoconazole / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole