title: Distance and oxygen desaturation in 6-min walk test predict prognosis in COPD patients.
abstract: The aim of the present study was to predict the prognosis of Chronic obstructive pulmonary disease (COPD) patients who underwent comprehensive pulmonary rehabilitation (PR). A total of 144 patients who performed PR between 1992 and 1999 was assessed. After PR, 67 patients underwent lung volume reduction surgery (LVRS). Baseline data before PR consisted of body mass index, serum albumin levels, use of supplement oxygen at home, pulmonary function, arterial blood gas analysis, and distance and fall of hemoglobin oxygen saturation (DeltaSpO(2)) in 6-min walk test. In addition to pre-PR factors, treatment with LVRS was taken into the analysis. The prognostic significance of variables influencing survival was determined by univariate analysis with Log rank test or multivariate analysis using Cox's proportional hazard model. By a median follow-up time of 8.4 years, the median survival time was 8.1 years (95% confidence interval: 6.9-9.4 years). Albumin level, PaCO(2), distance and DeltaSpO(2) were significant prognostic factors in univariate analysis. LVRS did not affect the prognosis. The multivariate analysis showed short distance and increase of DeltaSpO(2) as significant independent predictors of the risk of death. 6-min walk test was very useful for predicting the prognosis of the COPD patients.
authors.affiliation: Department of Internal Medicine, National Hospital Organization, Minami-Okayama Medical Center, 4066 Hayashima, Okayama 701 0304, Japan. ntakigaw@md.okayama-u.ac.jp
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Tada
authors.forename: Ryo
authors.initials: R
authors.lastname: Soda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
authors.forename: Motohiro
authors.initials: M
authors.lastname: Yamashita
authors.forename: Shigeto
authors.initials: S
authors.lastname: Endo
authors.forename: Syuji
authors.initials: S
authors.lastname: Takahashi
authors.forename: Noriko
authors.initials: N
authors.lastname: Kawata
authors.forename: Takuo
authors.initials: T
authors.lastname: Shibayama
authors.forename: Noboru
authors.initials: N
authors.lastname: Hamada
authors.forename: Motoi
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirano
authors.forename: Goro
authors.initials: G
authors.lastname: Kimura
authors.forename: Chiharu
authors.initials: C
authors.lastname: Okada
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000502:physiology; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D012129:Respiratory Function Tests / Q000379:methods; D012709:Serum Albumin / Q000032:analysis; D016019:Survival Analysis; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology
chemical_list: D012709:Serum Albumin; D002245:Carbon Dioxide; D010100:Oxygen