title: Admission blood glucose level and mortality among hospitalized nondiabetic patients with heart failure.
abstract: BACKGROUND
  The significance of admission blood glucose level in nondiabetic patients with heart failure (HF) is unknown. We examined the possible association between admission glucose levels and outcome in a large cohort of hospitalized patients with HF.
  
  
  METHODS
  We analyzed the data of 4102 patients with HF, who were hospitalized during a prospective national survey. The present study focuses on a subgroup of 1122 nondiabetic patients with acute HF who were admitted because of acute HF or exacerbation of chronic HF.
  
  
  RESULTS
  In-hospital mortality was twice as high in patients with admission blood glucose levels in the third tertile (7.2%) compared with the first (3%) and second (4%) tertiles (P = .02). Furthermore, mortality risk was correlated with admission glucose levels; each 18-mg/dL (1-mmol/L) increase in glucose level was associated with a 31% increased risk of in-hospital mortality (adjusted odds ratio, 1.31; 95% confidence interval, 1.10-1.57; P = .003) and a 12% increase in 60-day mortality (adjusted hazard ratio, 1.12; 95% confidence interval, 1.01-1.25; P = .04). Admission blood glucose levels remained an independent predictor of in-hospital and 60-day mortality even after the exclusion of 315 patients (28%) with acute myocardial infarction and HF. The 6- and 12-month mortality rates were similar in patients with and without abnormal admission blood glucose levels.
  
  
  CONCLUSIONS
  Elevated admission blood glucose levels are associated with increased in-hospital and 60-day mortality, but not 6-month or 1-year mortality, in nondiabetic patients hospitalized because of HF.
authors.affiliation: Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel.
authors.forename: Alon
authors.initials: A
authors.lastname: Barsheshet
authors.forename: Moshe
authors.initials: M
authors.lastname: Garty
authors.forename: Ehud
authors.initials: E
authors.lastname: Grossman
authors.forename: Amir
authors.initials: A
authors.lastname: Sandach
authors.forename: Basil S
authors.initials: BS
authors.lastname: Lewis
authors.forename: Shmuel
authors.initials: S
authors.lastname: Gottlieb
authors.forename: Abraham
authors.initials: A
authors.lastname: Shotan
authors.forename: Solomon
authors.initials: S
authors.lastname: Behar
authors.forename: Avi
authors.initials: A
authors.lastname: Caspi
authors.forename: Roseline
authors.initials: R
authors.lastname: Schwartz
authors.forename: Alexander
authors.initials: A
authors.lastname: Tenenbaum
authors.forename: Jonathan
authors.initials: J
authors.lastname: Leor
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D010343:Patient Admission; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D001786:Blood Glucose