Absorption of myo-inositol hexakisphosphate (InsP6) through the skin in humans.
In this paper, we present a pilot study of the absorption of myo-inositol hexakisphosphate (InsP6) through the skin in humans. We found that, after topical treatment with a 4% InsP6 rich gel, InsP6 urinary excretion increased 54% compared to the control situation (participants submitted to an InsP6-poor diet for 15 days, n = 6), clearly demonstrating that InsP6 is absorbed through the skin of humans. These results demonstrate the topical application as a suitable administration route of InsP6 in humans.
Grases
F
F
Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research, Faculty of Sciences, University of Balearic Islands, 07122 Palma de Mallorca, Spain. fgrases@uib.es
Isern
B
B
Perelló
J
J
Sanchis
P
P
Prieto
R M
RM
Costa-Bauzà
A
A
D000287:Administration, Topical; D000328:Adult; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D010833:Phytic Acid / Q000493:pharmacokinetics* / Q000652:urine; D012869:Skin Absorption / Q000502:physiology*
D010833:Phytic Acid