Endothelin, the kidney, and hypertension.
The kidneys play a central role in the long-term regulation of blood pressure and in the pathogenesis of hypertension. A common defect that has been found in all forms of hypertension examined to date is a hypertensive shift in the pressure-natriuresis relationship. A major objective of this brief review is to highlight some of the recent advances in our understanding of the mechanisms whereby the renal endothelin system, via endothelin type A- and endothelin type B-receptor activation, modulates renal pressure-natriuresis and blood pressure regulation under normal physiologic conditions and in certain forms of hypertension.
Granger
Joey P
JP
Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, 39216-4505, USA. jgranger@physiology.umsmed.edu
Abram
Sean
S
Stec
David
D
Chandler
Derrick
D
LaMarca
Babbette
B
D000818:Animals; D001794:Blood Pressure; D019332:Endothelin-1 / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D009318:Natriuresis; D017466:Receptors, Endothelin / Q000378:metabolism*; D012079:Renal Circulation; D012084:Renin-Angiotensin System; D014661:Vasoconstriction
D019332:Endothelin-1; D017466:Receptors, Endothelin