title: Chromatin modulation and the DNA damage response.
abstract: The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.
authors.affiliation: Genome Stability Laboratory, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway.
authors.forename: Thomas
authors.initials: T
authors.lastname: Costelloe
authors.forename: Jennifer
authors.initials: J
authors.lastname: Fitzgerald
authors.forename: Niall J
authors.initials: NJ
authors.lastname: Murphy
authors.forename: Andrew
authors.initials: A
authors.lastname: Flaus
authors.forename: Noel F
authors.initials: NF
authors.lastname: Lowndes
mesh_terms: D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly; D004249:DNA Damage; D004260:DNA Repair; D006657:Histones / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008745:Methylation; D008957:Models, Genetic; D008958:Models, Molecular; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational
chemical_list: D002843:Chromatin; C468783:H2AX protein, human; D006657:Histones