Identification of repressor element 1 in secretin/PACAP/VIP genes.
Repressor element 1 (RE-1) is a negative, cis-acting regulatory element that interacts with the transcription factor RE-1-silencing transcription factor (REST). REST represses gene expression by two repressor domains that recruit other factors including mSin3 and CoREST. RE-1 has been identified in an increasing number of neuronal-specific genes, and recently, functional REST sites have also been discovered in VIP and PACAP genes. In the present article, we demonstrated for the first time that RE-1 sites are present in the 5' flanking regions of several secretin/PACAP/VIP genes by in silico analysis. This observation suggests that RE-1/REST is a common negative regulatory pathway of this peptide family.
Lee
Leo T O
LT
Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, PRC.
Lee
Vien H Y
VH
Yuan
Paula Y
PY
Chow
Billy K C
BK
D000818:Animals; D019295:Computational Biology; D006801:Humans; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000145:classification / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D012633:Secretin / Q000145:classification / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014660:Vasoactive Intestinal Peptide / Q000145:classification / Q000235:genetics*; D000099229:RE1-Silencing Transcription Factor
D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D012097:Repressor Proteins; D012633:Secretin; D014157:Transcription Factors; D014660:Vasoactive Intestinal Peptide; D000099229:RE1-Silencing Transcription Factor