Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease.
Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant stimulation parameters resulted in a significant improvement of cognitive dysfunction and reduced the number of choreiform movements. This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD.
Temel
Yasin
Y
Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands. y.temel@np.unimaas.nl
Cao
Chunyan
C
Vlamings
Rinske
R
Blokland
Arjan
A
Ozen
Hatice
H
Steinbusch
Harry W M
HW
Michelsen
Kimmo A
KA
von Hörsten
Stephan
S
Schmitz
Christoph
C
Visser-Vandewalle
Veerle
V
D000818:Animals; D030801:Animals, Genetically Modified; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D046690:Deep Brain Stimulation / Q000379:methods* / Q000592:standards; D004195:Disease Models, Animal; D005917:Globus Pallidus / Q000503:physiopathology*; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D009068:Movement / Q000502:physiology; D009154:Mutation; D017072:Neostriatum / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000235:genetics; D009434:Neural Pathways / Q000503:physiopathology*; D009687:Nuclear Proteins / Q000235:genetics; D051381:Rats; D020127:Recovery of Function; D016896:Treatment Outcome
C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins