title: Impact of a massage therapy clinical trial on immune status in young Dominican children infected with HIV-1.
abstract: OBJECTIVE
  The effectiveness of massage therapy on immune parameters was evaluated in young Dominican HIV+ children without current access to antiretroviral therapies.
  
  
  METHODS
  Eligible children, who were followed at the Robert Reid Cabral Hospital (San Domingo, Dominican Republic), were randomized to receive either massage treatment or a control/friendly visit twice weekly for 12 weeks. Blood was drawn at baseline and following the 3-month intervention for determinations of CD4, CD8, and CD56 cell counts and percentage, along with activation markers (CD25 and CD69).
  
  
  RESULTS
  Despite similar immune parameters at baseline in the two groups, significantly more of the control group exhibited a decline in CD4 cell count (>30%, p = 0.03), postintervention. The decrease was particularly evident in older (5-8 years) children in the control arm, who demonstrated a significant reduction in both CD4 and CD8 cell counts compared to massage-treated older children who remained stable or showed immune improvement. Additionally, a significant increase in CD4+CD25+ cells was observed over the 12-week trial in the massage-treated older children (p = 0.04) but not in the control group. In younger massage-treated children, (2-4 years old), a significant increase in natural killer cells was shown.
  
  
  CONCLUSIONS
  Together these findings support the role for massage therapy in immune preservation in HIV+ children.
authors.affiliation: Division of Disease Prevention, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA. gshor@med.miami.edu
authors.forename: Gail
authors.initials: G
authors.lastname: Shor-Posner
authors.forename: Maria
authors.initials: M
authors.lastname: Hernandez-Reif
authors.forename: Maria-Jose
authors.initials: MJ
authors.lastname: Miguez
authors.forename: Maryann
authors.initials: M
authors.lastname: Fletcher
authors.forename: Noaris
authors.initials: N
authors.lastname: Quintero
authors.forename: Jeanette
authors.initials: J
authors.lastname: Baez
authors.forename: Eddy
authors.initials: E
authors.lastname: Perez-Then
authors.forename: Solange
authors.initials: S
authors.lastname: Soto
authors.forename: Rosangela
authors.initials: R
authors.lastname: Mendoza
authors.forename: Raquell
authors.initials: R
authors.lastname: Castillo
authors.forename: Guoyan
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000628:therapy*; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D004293:Dominican Republic; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D008405:Massage / Q000379:methods*; D016896:Treatment Outcome