[Distribution and expression of peroxisome proliferator activated receptor gamma in human pituitary adenomas].
OBJECTIVE
To evaluate the distribution and expression of peroxisome proliferator activated receptor gamma (PPAR-gamma) in human pituitary adenomas.


METHODS
Thirty eight consecutive surgically resected pituitary adenomas and 5 normal pituitary tissues were enrolled in the study. Immunohistochemistry was used to confirm the distribution of PPAR-gamma. Expression of PPAR-gamma was evaluated by Western blot.


RESULTS
PPAR-gamma immunoreactivity was located in the nucleoli of pituitary adenoma cells. PPAR-gamma was expressed in all human pituitary adenomas and normal pituitary tissues. Its expression in pituitary adenomas was significantly higher than in normal pituitary tissues (P < 0.01), and its expression in ACTH-secreting adenomas was significantly higher than in any other type of pituitary adenomas (P < 0.05).


CONCLUSIONS
PPAR-gamma may play an important role in the generation, growth, and invasion of human pituitary adenomas. It may become a novel therapeutic target for these tumors.
Ma
Yan
Y
Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Xia
Xue-Wei
XW
Su
Chang-Bao
CB
Kong
Yan-Guo
YG
D049913:ACTH-Secreting Pituitary Adenoma / Q000378:metabolism*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000096:biosynthesis* / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism*
D047495:PPAR gamma