title: A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality.
abstract: BACKGROUND
  To investigate the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality.
  
  
  METHODS
  We compared the occurrence of HLA-DR and HLA-DQ antigens in patients with intracranial saccular aneurysm and in the control group by PCR and agarose gel electrophoresis.
  
  
  RESULTS
  No statistically significant correlation between HLA-DR, HLA-DQ antigen frequency, and the pathogenesis and clinical characteristics of intracranial aneurysm has been found.
  
  
  CONCLUSIONS
  We have not found any relationship between HLA-DR and HLA-DQ antigen frequency, haplotype frequency, and pathogenesis and clinical characteristics of intracranial aneurysm, but the patients who presented with HLA-DR53, DR52, DQ7(3), and DQ5(1) seem to be more likely to bear multiple intracranial aneurysms.
authors.affiliation: Department of Neurosurgery, Beijing TianTan Hospital, Capital University of Medical Sciences, Beijing 100050, China. wjf1998@yeah.net
authors.forename: Jiang-Fei
authors.initials: JF
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Ji-Zong
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Jia
authors.forename: Ru-Mei
authors.initials: RM
authors.lastname: Bi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D002532:Intracranial Aneurysm / Q000208:ethnology* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens