[Effect of allogenic intracranial transplantation of embryonal neural cell-precursors on the humoral immune response to neurospecific proteins in rabbits].
The purpose of the study was to prepare the neural precursors and evaluate the humoral autoimmune response to neuro-specific antigens in rabbits after intracranial transplantation of the prepared cells. The cell suspension enriched with vimentin-positive progenitor neurocells up to 70-80% was received on 9th day after cultivation of embryonal rabbit neurocells in DMEM+retinol acetate medium. The autoimmune responses to neuronspecific enolase were established in 30% of rabbits 1-3 months after intracranial neural precursors transplantation.
Lisianyĭ
M I
MI
Liubych
L D
LD
Cherchenko
A P
AP
Verkhohliadov
Iu P
IuP
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001921:Brain / Q000166:cytology* / Q000196:embryology*; D002452:Cell Count; D002470:Cell Survival / Q000276:immunology; D004224:Diterpenes; D011817:Rabbits; D000084562:Retinyl Esters; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014746:Vimentin / Q000378:metabolism; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology
D001323:Autoantibodies; D004224:Diterpenes; D000084562:Retinyl Esters; D014746:Vimentin; D014801:Vitamin A; C009166:retinol acetate