Two new bioactive sesquiterpenes from the soft coral Sinularia sp.
Two new sesquiterpenes, 1S*, 4R*, 5S*, 6R*, 7S*, 10S*-1(5), 6(7)-diepoxy-4-guaiol (1) and 1S*, 4S*, 5S*, 10R*-4,10-guaianediol (2) have been isolated from the ethyl acetate soluble portion of the soft coral Sinularia sp., and their stereostructure were determined by spectroscopic methods and by X-ray single crystal analysis. Both compounds showed antioxidant and cytotoxic activities.
Zhang
Guang-Wen
GW
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
Ma
Xiang-Quan
XQ
Su
Jing-Yu
JY
Zhang
Kun
K
Kurihara
Hiroshi
H
Yao
Xin-Sheng
XS
Zeng
Long-Mei
LM
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D000975:Antioxidants; D012717:Sesquiterpenes