Remodeled cardiac calcium channels.
Cardiac calcium channels play a pivotal role in the proper functioning of cardiac cells. In response to various pathologic stimuli, they become remodeled, changing how they function, as they adapt to their new environment. Specific features of remodeled channels depend upon the particular disease state. This review will summarize what is known about remodeled cardiac calcium channels in three disease states: hypertrophy, heart failure and atrial fibrillation. In addition, it will review the recent advances made in our understanding of the function of the various molecular building blocks that contribute to the proper functioning of the cardiac calcium channel.
Pitt
Geoffrey S
GS
Department of Medicine, Columbia University, New York, NY, USA.
Dun
Wen
W
Boyden
Penelope A
PA
D000818:Animals; D001281:Atrial Fibrillation; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000737:chemistry* / Q000502:physiology*; D006333:Heart Failure / Q000473:pathology; D006801:Humans; D006984:Hypertrophy; D008954:Models, Biological; D009200:Myocardial Contraction; D017434:Protein Structure, Tertiary
D015220:Calcium Channels; D002118:Calcium