Organohalogen compounds in human breast milk from Republic of Buryatia, Russia.
Human breast milk samples collected during 2003/04 in Buryatia, a Russian autonomous republic, were analyzed in order to assess human exposure to organohalogen compounds including organochlorine pesticides, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs). When compared with available worldwide data, levels of HCB (23-880 ng/g lipid wt.), PCBs (69-680 ng/g lipid wt.), and HCHs (100-3700 ng/g lipid wt.) were relatively high, indicating elevated human exposure to these organochlorines (OCs) in Buryatia. In contrast to OCs, PBDE concentrations were low (0.46-1.7 ng/g lipid wt.). Out of 14 BDE congeners analyzed, BDE-28, BDE-47, BDE-100, BDE-153, BDE-197, and BDE-207 were detected. Estimated daily intakes (EDIs) of HCHs, HCB, CHLs, and PCBs by infants solely from human milk for 100%, 43%, 34%, and 17% of the samples, respectively, exceeded guideline thresholds. Although high EDIs raise concern for possible toxic effects of OCs, women in Buryatia are recommended to breastfeed due to numerous advantages of breastfeeding for mother and child.
Tsydenova
Oyuna V
OV
Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
Sudaryanto
Agus
A
Kajiwara
Natsuko
N
Kunisue
Tatsuya
T
Batoev
Valeriy B
VB
Tanabe
Shinsuke
S
D000328:Adult; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000032:analysis*; D005260:Female; D055768:Halogenated Diphenyl Ethers; D006581:Hexachlorobenzene / Q000032:analysis; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008423:Maternal Age; D008895:Milk, Human / Q000737:chemistry*; D010298:Parity; D010573:Pesticide Residues / Q000032:analysis*; D010647:Phenyl Ethers / Q000032:analysis; D011075:Polybrominated Biphenyls / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis; D011247:Pregnancy; D012426:Russia
D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D006846:Hydrocarbons, Halogenated; D010573:Pesticide Residues; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; D006581:Hexachlorobenzene; C086401:pentabromodiphenyl ether; D011078:Polychlorinated Biphenyls