The lactic acid-induced acid tolerance response in Salmonella enterica serovar Typhimurium induces sensitivity to hydrogen peroxide.
Transcriptome analyses of Salmonella enterica serovar Typhimurium revealed that 15 genes were significantly up-regulated after 2 h of adaptation with lactic acid. cadB was the most highly up-regulated gene and was shown to be an essential component. Lactic acid-adapted cells exhibited sensitivity to hydrogen peroxide, likely due to down-regulation of the OxyR regulon.
Greenacre
E J
EJ
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, United Kingdom. elizabeth.greenacre@bbsrc.ac.uk
Lucchini
S
S
Hinton
J C D
JC
Brocklehurst
T F
TF
D026905:Amino Acid Transport Systems / Q000235:genetics / Q000378:metabolism; D017920:Antiporters / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D019344:Lactic Acid / Q000494:pharmacology*; D020543:Proteome; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development*; D014158:Transcription, Genetic
D026905:Amino Acid Transport Systems; D017920:Antiporters; D001426:Bacterial Proteins; C088101:CadB protein, Bacteria; D020543:Proteome; D019344:Lactic Acid; D006861:Hydrogen Peroxide