Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005.
From 2003 to 2005, deaths of 3 individuals as a result of cardiac arrest caused by hypocalcemia during chelation therapy were reported to the Centers for Disease Control and Prevention. Two were children, both of whom were treated with edetate disodium. At the time of this writing, the adult case was still under investigation. No previous cases of death resulting from hypocalcemia during chelation have been reported. From our experience and review of the literature, we suggest that health care providers who are unfamiliar with chelation consult an expert before undertaking treatment and that hospital formularies evaluate whether stocking edetate disodium is necessary, given the risk for hypocalcemia and the availability of less toxic alternatives.
Brown
Mary Jean
MJ
Lead Poisoning Prevention Branch, Division of Emergency and Environmental Health Services, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. mjb5@cdc.gov
Willis
Teresa
T
Omalu
Bennet
B
Leiker
Richard
R
D001321:Autistic Disorder / Q000188:drug therapy; D002118:Calcium / Q000008:administration & dosage; D002614:Chelating Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015913:Chelation Therapy / Q000009:adverse effects*; D002675:Child, Preschool; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced* / Q000150:complications; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology*; D007262:Infusions, Intravenous; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D008508:Medication Errors; D008875:Middle Aged; D009324:Naturopathy; D012308:Risk Management; D012964:Sodium / Q000008:administration & dosage; D004113:Succimer / Q000008:administration & dosage / Q000627:therapeutic use
D002614:Chelating Agents; D004492:Edetic Acid; D012964:Sodium; D004113:Succimer; D002118:Calcium