title: Pleural malignant solitary fibrous tumor with sarcomatous overgrowth showing PDGFRbeta mutation.
abstract: Pleural malignant solitary fibrous tumors (SFTs) are uncommon, and little is known about their histogenesis and molecular features. We report a case of pleural SFT with sarcomatous overgrowth that showed expression for PDGFRbeta and a missense mutation on exon 18 of the PDGFRbeta gene. The involvement of the PDGFRbeta gene in SFT is compatible with a pericytic derivation, also supporting a possible role of this tyrosine kinase in malignant transformation and in the adoption of novel molecular therapies.
authors.affiliation: Section of Pathologic Anatomy, University of Modena and Reggio Emilia, Modena, Italy. rossi.giulio@unimo.it
authors.forename: Giulio
authors.initials: G
authors.lastname: Rossi
authors.forename: Laura
authors.initials: L
authors.lastname: Schirosi
authors.forename: Filippo
authors.initials: F
authors.lastname: Giovanardi
authors.forename: Giuliana
authors.initials: G
authors.lastname: Sartori
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Paci
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
mesh_terms: D000368:Aged; D001706:Biopsy; D001999:Bronchoscopy; D004273:DNA, Neoplasm / Q000235:genetics*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009154:Mutation; D018218:Neoplasms, Fibrous Tissue / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D010997:Pleural Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics*; D012509:Sarcoma / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014057:Tomography, X-Ray Computed
chemical_list: D004273:DNA, Neoplasm; D020797:Receptor, Platelet-Derived Growth Factor beta