Carbamazepine-induced hypersensitivity syndrome occurring in a photodistributed pattern.
A 76- year- old man was commenced on carbamazepine for partial seizures. This was followed by the development of a rash in an apparently photodistributed pattern, fever, lymphadenopathy, eosinophilia, abnormal liver function tests and atypical lymphocytosis fulfilling the criteria for drug-induced hypersensitivity syndrome. Discontinuation of carbamazepine and application of topical steroid resulted in clearance of the rash, normalization of liver function tests and improvement in eosinophilia. The photodistributed pattern in this case of carbamazepine-induced hypersensitivity syndrome is of interest.
So
J S Y
JS
Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK. j.so@orange.net
Edwards
S L
SL
Ibbotson
S H
SH
D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004828:Epilepsies, Partial / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012867:Skin / Q000473:pathology*; D013577:Syndrome
D000927:Anticonvulsants; D002220:Carbamazepine