title: Creutzfeldt-Jakob disease: comparative analysis of MR imaging sequences.
abstract: OBJECTIVE
  MR imaging has played an increasingly important role in the diagnosis of Creutzfeldt-Jakob disease (CJD) since basal ganglia abnormalities on T2-weighted images have been described; thus, the aim of our study was to compare the value of different MR images in the diagnosis of CJD.
  
  
  METHODS
  One hundred fifty-seven patients with CJD underwent MR imaging examinations. Ninety-two patients were neuropathologically confirmed, and 65 were clinically classified as having CJD through the CJD Surveillance Unit (probability of 95%). There was no standardized MR imaging protocol; thus, the examinations included 143 T2-weighted, 43 proton attenuation (PD)-weighted, 84 fluid-attenuated inversion recovery (FLAIR), and 44 diffusion-weighted images (DWI). The MR images were reviewed for pathologic changes of the basal ganglia, thalamus, and cerebral cortex.
  
  
  RESULTS
  Cortical abnormalities were present in 70 patients (45%) and were visible in 80% (35/44) of all available DWI examinations. The basal ganglia were affected in 94 patients (60%), in particular in the caudate nucleus; the most sensitive sequences were DWI (64%) and PD-weighted (63%). A thalamic involvement was more frequently diagnosed on PD-weighted images (19%) and DWI (14%) than on FLAIR or T2-weighted images.
  
  
  CONCLUSIONS
  PD-weighted images and DWI showed better results in the diagnosis of signal intensity changes in the basal ganglia compared with T2-weighted or FLAIR images; however, in the diagnosis of cortical changes, DWI was clearly superior. Our data suggest that DWI is the most sensitive MR imaging technique in the diagnosis of CJD.
authors.affiliation: Department of Neuroradiology, Georg-August University Medical Center, Robert-Koch-Strasse 40, Goettingen 37075, Germany. kai.kallenberg@meduni-goettingen.de
authors.forename: K
authors.initials: K
authors.lastname: Kallenberg
authors.forename: W J
authors.initials: WJ
authors.lastname: Schulz-Schaeffer
authors.forename: U
authors.initials: U
authors.lastname: Jastrow
authors.forename: S
authors.initials: S
authors.lastname: Poser
authors.forename: B
authors.initials: B
authors.lastname: Meissner
authors.forename: H J
authors.initials: HJ
authors.lastname: Tschampa
authors.forename: I
authors.initials: I
authors.lastname: Zerr
authors.forename: M
authors.initials: M
authors.lastname: Knauth
mesh_terms: D001479:Basal Ganglia / Q000473:pathology; D002421:Caudate Nucleus / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011699:Putamen / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013788:Thalamus / Q000473:pathology