Repeated dexmedetomidine infusions, a postoperative living-donor liver transplantation patient.
Here we report on a postoperative living-donor liver transplantation (LDLT) patient who received nightly infusions of dexmedetomidine (DEX), a specific alpha2-adrenergic receptor agonist, to treat agitation and insomnia during an intensive care unit stay. The infusion rate was adjusted according to the Ramsay sedation score. The actual plasma concentrations were higher than the values predicted by RugLoop software package simulation 9 h after the DEX infusion. However, all of the measurements were within the therapeutic range for DEX. Thus, DEX infusion could be safely used in the postoperative LDLT patient by employing a simple consciousness scale.
Terajima
Katsuyuki
K
Department of Anesthesiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Takeda
Shinhiro
S
Taniai
Nobuhiko
N
Tanaka
Keiji
K
Oda
Yutaka
Y
Asada
Akira
A
Sakamoto
Atsuhiro
A
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D016031:Liver Transplantation; D019520:Living Donors; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000188:drug therapy*; D011595:Psychomotor Agitation / Q000188:drug therapy; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D020927:Dexmedetomidine