Whole genome RNAi screens for increased longevity: important new insights but not the whole story.
This article discusses the pros and cons of using RNAi screening to identify longevity genes in Caenorhabditis elegans. The discussion will focus on the results of two large-scale longevity RNAi screens that were recently published. The two screens revealed largely non-overlapping sets of candidate longevity genes. The possible reasons for such differences and their implications will be discussed.
Lee
Siu Sylvia
SS
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA. SSL29@cornell.edu
D000375:Aging / Q000235:genetics*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics; D015723:Gene Library; D049751:Genome, Helminth / Q000235:genetics; D008136:Longevity / Q000235:genetics; D023421:Models, Animal; D034622:RNA Interference; D018510:RNA, Helminth / Q000235:genetics*; D034741:RNA, Small Interfering / Q000235:genetics*
D029742:Caenorhabditis elegans Proteins; D018510:RNA, Helminth; D034741:RNA, Small Interfering