Effect of inhaled salbutamol on coronary circulation in humans.
In 12 patients we assessed the effect of inhaled salbutamol on the coronary circulation. According to our results, large doses of salbutamol increase coronary flow, but not in proportion to the needs of the myocardium (as documented by the increase in coronary oxygen extraction), and decrease coronary flow reserve. These effects may have deleterious consequences in patients with coronary artery disease, causing or worsening myocardial ischemia.
Kochiadakis
George E
GE
Hamilos
Michael I
MI
Skalidis
Emmanuel I
EI
Igoumenidis
Nikolaos E
NE
Schiza
Sophia E
SE
Vardas
Panos E
PE
D000280:Administration, Inhalation; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000420:Albuterol / Q000008:administration & dosage*; D003326:Coronary Circulation / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged
D000318:Adrenergic beta-Agonists; D000420:Albuterol