Current concepts in the diagnosis and management of metabolic complications of HIV infection and its therapy.
Changes in fat distribution, dyslipidemia, disordered glucose metabolism, and lactic acidosis have emerged as significant challenges to the treatment of human immunodeficiency virus (HIV) infection. Over the past decade, numerous investigations have been conducted to better define these conditions, identify risk factors associated with their development, and test potential therapeutic interventions. The lack of standardized diagnostic criteria, as well as disparate study populations and research methods, have led to conflicting data regarding the diagnosis and treatment of metabolic and body shape disorders associated with HIV infection. On the basis of a review of the medical literature published and/or data presented before April 2006, we have prepared a guide to assist the clinician in the detection and management of these complications.
Wohl
D A
DA
Div. of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA. wohl@med.unc.edu
McComsey
G
G
Tebas
P
P
Brown
T T
TT
Glesby
M J
MJ
Reeds
D
D
Shikuma
C
C
Mulligan
K
K
Dube
M
M
Wininger
D
D
Huang
J
J
Revuelta
M
M
Currier
J
J
Swindells
S
S
Fichtenbaum
C
C
Basar
M
M
Tungsiripat
M
M
Meyer
W
W
Weihe
J
J
Wanke
C
C
D050171:Dyslipidemias / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D044882:Glucose Metabolism Disorders / Q000209:etiology* / Q000628:therapy; D015658:HIV Infections / Q000150:complications*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced / Q000175:diagnosis* / Q000628:therapy; D006801:Humans