title: Stridor in Crohn disease and the use of infliximab.
abstract: Extraintestinal manifestations of Crohn disease are well recognized. Upper airway obstruction is a very rare but important complication that usually responds to high-dose steroids. We report a case of Crohn disease initially presenting with respiratory symptoms and subsequently resulting in acute severe upper airway obstruction, which failed to respond to steroids but dramatically responded to the first documented use of infliximab in this context.
authors.affiliation: Nottingham City Hospital, UK.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kirkcaldy
authors.forename: Wei Shen
authors.initials: WS
authors.lastname: Lim
authors.forename: Adrian
authors.initials: A
authors.lastname: Jones
authors.forename: Kate
authors.initials: K
authors.lastname: Pointon
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001999:Bronchoscopy; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D012135:Respiratory Sounds / Q000175:diagnosis* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab