title: Association of conversion & cure with initial smear grading among new smear positive pulmonary tuberculosis patients treated with Category I regimen.
abstract: OBJECTIVE
  Early diagnosis of tuberculosis (TB) is important for initiating treatment to gain cure. The present investigation was undertaken to study the association of conversion and cure with initial smear grading among pulmonary tuberculosis (TB) patients registered in a directly observed treatment - short course (DOTS) programme in Tiruvallur district, south India.
  
  
  METHODS
  All new smear positive cases registered from May, 1999 to December, 2002 were analysed for conversion and cure related to initial smear grading.
  
  
  RESULTS
  Of the 1463 patients, 1206(82.4%) were converted at the end of the intensive phase and 1109 (75.8%) were declared 'cured' after the completion of treatment. The cure rate decreased as the initial smear grading increased and the decrease in trend was statistically significant (P=0.01). Similarly, a significant decrease in conversion rate was also observed with increase in initial smear grading (P<0.001). In multivariate analysis, lower cure rate was significantly associated with patient's age (AOR=1.5, 95% CI=1.1-2.1), alcoholism (AOR=1.7, 95% CI 1.2- 2.4) and conversion at the end of intensive phase (AOR=3.5, 95% CI= 2.6-4.8).
  
  
  CONCLUSIONS
  Cure and conversion rates were linearly associated with initial smear grading. High default and death rates were responsible for low cure and conversion. The proportion of patients who required extension of treatment and those who had an unfavourable treatment outcome were significantly higher among patients with a 3+ initial smear grading. This reiterates the need to pay more attention in motivating these patients to return to regular treatment and sustained commitment in the control of tuberculosis. There is a need to extend the treatment for one more month in the intensive phase of treatment.
authors.affiliation: Tuberculosis Research Centre (ICMR), Chennai, India.
authors.forename: P G
authors.initials: PG
authors.lastname: Gopi
authors.forename: V
authors.initials: V
authors.lastname: Chandrasekaran
authors.forename: R
authors.initials: R
authors.lastname: Subramani
authors.forename: T
authors.initials: T
authors.lastname: Santha
authors.forename: A
authors.initials: A
authors.lastname: Thomas
authors.forename: N
authors.initials: N
authors.lastname: Selvakumar
authors.forename: P R
authors.initials: PR
authors.lastname: Narayanan
mesh_terms: D000328:Adult; D000367:Age Factors; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D023801:Directly Observed Therapy / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D013183:Sputum / Q000382:microbiology; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D000904:Antibiotics, Antitubercular