title: Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin.
abstract: Proper fatty acid metabolism is critical for hair and skin development and maintenance. The acyl-CoA binding protein (Acbp) is a widely expressed protein that binds long-chain fatty acyl-CoA esters and plays a role in fatty acyl-CoA transport and pool formation. However, loss of function of Acbp in the whole animal has not been investigated. Here, we show that deletion of Acbp in mouse results in sebocyte hyperplasia and sparse, matted hair with a greasy appearance. Consistent with these gross abnormalities, Acbp is highly expressed in the pilosebaceous units of mouse skin as determined by Northern analysis and in situ hybridization. Loss of Acbp also results in fatty acid metabolism abnormalities, with hair lipid profiles showing altered levels of triacylglycerols and nearly co-migrating lipids. These data suggest that Acbp plays a role in triacylglycerol biosynthesis, and that regulation of this process is important for proper hair and skin development and maintenance in the mouse.
authors.affiliation: Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Lance
authors.initials: L
authors.lastname: Lee
authors.forename: C Anthony
authors.initials: CA
authors.lastname: DeBono
authors.forename: Dean R
authors.initials: DR
authors.lastname: Campagna
authors.forename: David C
authors.initials: DC
authors.lastname: Young
authors.forename: D Branch
authors.initials: DB
authors.lastname: Moody
authors.forename: Mark D
authors.initials: MD
authors.lastname: Fleming
mesh_terms: D000818:Animals; D026261:Diazepam Binding Inhibitor / Q000032:analysis / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D006197:Hair / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation; D047495:PPAR gamma / Q000235:genetics / Q000502:physiology; D012867:Skin / Q000378:metabolism*; D014280:Triglycerides / Q000096:biosynthesis
chemical_list: D026261:Diazepam Binding Inhibitor; D005227:Fatty Acids; D047495:PPAR gamma; D014280:Triglycerides