Immunohistochemical distribution of amyloid deposits in 25 cows diagnosed with systemic AA amyloidosis.
The distribution of amyloid deposits was histopathologically and immunohistochemically examined in 25 cows aged 5 to 10 years that had been diagnosed with systemic AA amyloidosis. This examination revealed that amyloid deposits were also present in the hypophysis, ovary, uterus, mammary gland and skeletal muscle, in addition to the liver, kidney, spleen, pancreas, thyroid gland, adrenal gland, gastrointestinal mucosa, heart, lung and lymph nodes. The examined cows tended to have chronic inflammations, including chronic mastitis (six cases) or chronic pneumonia (four cases), which is thought of as a causative agent of AA amyloidosis. In contrast, five cases did not exhibit any chronic inflammation.
Yamada
Manabu
M
National Institute of Animal Health, Tsukuba, Japan.
Kotani
Yuri
Y
Nakamura
Kikuyasu
K
Kobayashi
Yoshiyasu
Y
Horiuchi
Noriyuki
N
Doi
Takuya
T
Suzuki
Satoshi
S
Sato
Norihiro
N
Kanno
Takeshi
T
Matsui
Takane
T
D000375:Aging; D000682:Amyloid / Q000302:isolation & purification*; D000686:Amyloidosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology; D010053:Ovary / Q000473:pathology; D010902:Pituitary Gland / Q000473:pathology
D000682:Amyloid