Disseminated crytococcosis with extensive cutaneous involvement in AIDS.
Cutaneous infections is observed in 15% of patients with disseminated cryptococcosis with AIDS. We present here a case of a 34 years old female with AIDS. She presented with multiple skin coloured umbilicated over face, neck, trunk and limbs, which mimicked molluscum contagiosum and kaposi sarcoma. The tissue from cutaneous lesions was collected by excision biopsy and processed by standard mycological methods. Cryptococcus neoformans was isolated and identified. Cerebrospinal fluid (CSF) also yielded the growth of C. neoformans . Cryptococcal antigen was detected with a titre of 1024 by Latex agglutination, is serum and CSF. Her serum was reactive for HIVI and 2 antibodies. The CD4 lymphocytes count was 80/cmm. The HIV viral load was 2,48,084 copies/mL. She was treated with amphotericin B injectable and oral fluconazole. She responded well and lesions regressed.
Dharmshale
S N
SN
Department of Microbiology, Grant Medical College and Sir J J Group of Hospital, Mumbai - 400 008, India. sujatadharmshale@rediffmail.com
Patil
S A
SA
Gohil
A
A
Chowdhary
A
A
Oberoi
C
C
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D003453:Cryptococcosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole