[Local recurrence of renal cell carcinoma after radical nephrectomy].
Radical nephrectomy was made in 483 patients with renal cell carcinoma (RCC) without metastases admitted to National Urology Center in 1989-2004. Isolated local recurrence was observed in 10 (2.07%) patients who were divided into two groups. The recurrent tumor was removed in 6 patients of group 1, four patients of group 2 received conservative treatment. Statistic processing was made with Kolmogorov-Smirnov test and unmatched t-test. Survival was estimated according to Kaplan-Meyer, significance of the differences--by log rank test. Three patients of group 1 died of progression of basic disease. Only 1 patient from group 2 was alive 22 months after detection of the recurrence. Mean survival in group 1 was 27.5 +/- 14.9 months, in group 2--10 +/- 8.5 months (p = 0.045). A mean size of the recurrent tumor in survivors was 5.4 +/- 2.1 cm, while in dead patients--10.05 +/- 2.76 cm (p = 0.02). Radicalism of the recurrent tumor removal influenced survival of the patients (p = 0.019). In survivors local recurrence developed 35.7 +/- 28.1 months after radical nephrectomy; in the deceased the recurrence arose 23.3 +/- 25.5 months after nephrectomy (p = 0.46). Thus, early detection of isolated local recurrence of a relatively small size allows complete recovery in some surgically treated patients.
Pertiia
A R
AR
Managadze
L G
LG
D002292:Carcinoma, Renal Cell / Q000401:mortality* / Q000601:surgery; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality* / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000401:mortality*; D009392:Nephrectomy