title: Development of suspending agent from sodium carboxymethyl mungbean starches.
abstract: Three sodium carboxymethyl mungbean starches (SCMMSs) were selected, based on the physicochemical profiles and evaluated as potential pharmaceutical suspending agent in comparison with a sodium carboxymethyl tapioca starch and other five commercial suspending agents. Ibuprofen suspension was employed as a model formulation with 0.5, 1.0, and 2.0% w/v of suspending agents. Evaluation parameters included the determination of sedimentation volume ratio, redispersibility, viscosity and rheological properties and content uniformity studies. The results revealed that a high-viscosity modified mungbean starch, MMS-M-04, possessed suitable properties as a suspending agent and, at 1% concentration, was as effective as sodium carboxymethylcellulose and xanthan gum, two most-commonly used suspending agents. This modified starch could be further developed and employed as a new commercial suspending agent in the pharmaceutical industry.
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Thailand. ornanong@pharmacy.cmu.ac.th
authors.forename: O S
authors.initials: OS
authors.lastname: Kittipongpatana
authors.forename: J
authors.initials: J
authors.lastname: Sirithunyalug
mesh_terms: D005079:Excipients / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry; D012212:Rheology; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry; D013535:Suspensions / Q000737:chemistry*; D014783:Viscosity
chemical_list: D005079:Excipients; D013535:Suspensions; D013213:Starch; C034848:carboxymethyl starch; D007052:Ibuprofen