title: Bacillisporins D and E, new oxyphenalenone dimers from Talaromyces bacillisporus.
abstract: The oligophenalenone dimer duclauxin and two new analogues, bacillisporins D and E, were isolated from the fungus TALAROMYCES BACILLISPORUS in addition to the previously reported bacillisporins A, B and C. Structures were established by spectroscopic studies. Duclauxin and bacillisporins A, B, C and E were evaluated for cytotoxicity against three human cancer cell lines. Bacillisporin A was strongly active against MCF-7 and NCI-H460 and moderately active against SF-268 while bacillisporins B, C and duclauxin were moderately active against all three cell lines.
authors.affiliation: Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand.
authors.forename: Tida
authors.initials: T
authors.lastname: Dethoup
authors.forename: Leka
authors.initials: L
authors.lastname: Manoch
authors.forename: Anake
authors.initials: A
authors.lastname: Kijjoa
authors.forename: Maria São
authors.initials: MS
authors.lastname: Nascimento
authors.forename: Prapawadee
authors.initials: P
authors.lastname: Puaparoj
authors.forename: Artur M
authors.initials: AM
authors.lastname: Silva
authors.forename: Graham
authors.initials: G
authors.lastname: Eaton
authors.forename: Werner
authors.initials: W
authors.lastname: Herz
mesh_terms: D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D019281:Dimerization; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D043803:Phenalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D032901:Talaromyces / Q000737:chemistry*
chemical_list: D002867:Chromones; D003603:Cytotoxins; D043803:Phenalenes; C515798:bacillisporin D; C515799:bacillisporin E; C007564:duclauxin