Fluostatins C-E, novel members of the fluostatin family produced by Streptomyces strain Acta 1383.
Three new members of the fluostatin family, fluostatins C-E, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.
Baur
Stefanie
S
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Niehaus
Jörg
J
Karagouni
Amalia D
AD
Katsifas
Efstathios A
EA
Chalkou
Kalliopi
K
Meintanis
Christos
C
Jones
Amanda L
AL
Goodfellow
Michael
M
Ward
Alan C
AC
Beil
Winfried
W
Schneider
Kathrin
K
Süssmuth
Roderich D
RD
Fiedler
Hans-Peter
HP
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005449:Fluorenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry*
D000970:Antineoplastic Agents; D005449:Fluorenes; C512873:fluostatin C; C512874:fluostatin D; C512875:fluostatin E