title: Polyhexamethylenebiguanide hydrochloride exposure and erythema multiforme in a physician.
abstract: A 52-year-old woman physician developed recurrent erythema multiforme. Occupational and environmental exposure assessment suggested a disinfectant containing polyhexamethylenebiguanide hydrochloride (PHMB), Phagosept. Elimination of the product was followed by disappearance of symptomatology. Literature search revealed cases of sensitization and anaphylaxis due to contact with PHMB, but to our knowledge, this is the first report on PHMB-induced erythema multiforme.
authors.affiliation: Department of Occupational Medicine, Rouen University Hospital Charles Nicolle, Rouen, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Gehanno
authors.forename: Anne-Emmanuelle
authors.initials: AE
authors.lastname: Priot
authors.forename: Xavier
authors.initials: X
authors.lastname: Balguerie
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Caillard
mesh_terms: D001645:Biguanides / Q000009:adverse effects*; D004892:Erythema Multiforme / Q000503:physiopathology*; D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure; D010820:Physicians
chemical_list: D001645:Biguanides; C031233:polihexanide