title: Lack of association of VEGF promoter polymorphisms with sporadic ALS.
abstract: The authors tested the association of three vascular endothelial growth factor (VEGF) promoter polymorphisms with sporadic ALS (SALS) to verify the results of a previous study and to investigate their modifier effects on the subphenotypes of SALS in a large family-based and case-control cohort of North American white subjects (N = 1,603). They did not find any association of the VEGF promoter polymorphisms with SALS or its subphenotypes, suggesting that they do not have a direct causal role in ALS.
authors.affiliation: Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Saeed
authors.forename: H
authors.initials: H
authors.lastname: Mao
authors.forename: N
authors.initials: N
authors.lastname: Siddique
authors.forename: L
authors.initials: L
authors.lastname: Dellefave
authors.forename: W-Y
authors.initials: WY
authors.lastname: Hung
authors.forename: H-X
authors.initials: HX
authors.lastname: Deng
authors.forename: R L
authors.initials: RL
authors.lastname: Sufit
authors.forename: S L
authors.initials: SL
authors.lastname: Heller
authors.forename: J L
authors.initials: JL
authors.lastname: Haines
authors.forename: M
authors.initials: M
authors.lastname: Pericak-Vance
authors.forename: T
authors.initials: T
authors.lastname: Siddique
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A