Neuropharmacological evaluation of Ginkgo biloba phytosomes in rodents.
On oral administration, Ginkgo biloba phytosomes significantly reduced pentobarbitone-induced sleeping time, produced an alteration in the general behaviour pattern, increased spontaneous motility and inhibited the chlorpromazine-induced blockade of conditioned and unconditioned responses in rodents. They exhibited both antiamnestic and antidepressant activities in the scopolamine-induced amnesia test and behavioural despair test, respectively. However, the phytosomes failed to show anticonvulsant activity. The observations suggest that the G. biloba phytosomes possess moderate antiamnestic/nootropic activity.
Naik
Suresh R
SR
Department of Pharmacology and Toxicology, Principal K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai 400 005, India. srnaik5@rediffmail.com
Pilgaonkar
Vinaya W
VW
Panda
Vandana S
VS
D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002491:Central Nervous System Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D007538:Isoniazid / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D018697:Nootropic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010424:Pentobarbital / Q000037:antagonists & inhibitors; D010713:Phosphatidylcholines / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000037:antagonists & inhibitors; D012890:Sleep
D000927:Anticonvulsants; D000928:Antidepressive Agents; D002491:Central Nervous System Agents; D018697:Nootropic Agents; D010713:Phosphatidylcholines; D010936:Plant Extracts; D012601:Scopolamine; D010424:Pentobarbital; D007538:Isoniazid