title: Haptoglobin gene promoter polymorphism and haplotypes are unique in different populations.
abstract: We investigated the distribution of haptoglobin (HP) alleles and haplotypes among Africans (Ghanaians), Europeans (from South Africa), and Chinese. HP*1F was present only in Africans and Europeans, whereas HP*del was unique to Chinese. Six base substitutions at the promoter region were population specific. Only 3 out of 18 haplotypes were shared among the populations. A probable application of HP in human population genetics appears legitimate.
authors.affiliation: Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Japan.
authors.forename: Kwesi
authors.initials: K
authors.lastname: Teye
authors.forename: Mikiko
authors.initials: M
authors.lastname: Soejima
authors.forename: Isaac K E
authors.initials: IK
authors.lastname: Quaye
authors.forename: Hao
authors.initials: H
authors.lastname: Pang
authors.forename: Makoto
authors.initials: M
authors.lastname: Tsuneoka
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Koda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000349:Africa; D000483:Alleles; D002681:China; D005060:Europe; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics*; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D006242:Haptoglobins