Efficacy of voriconazole in experimental Cryptococcus neoformans infection.
Voriconazole is a third generation triazole with improved activity against many fungal pathogens. We examined the efficacy of voriconazole in a murine infection model and evaluated the drug's effect on cellular characteristics and serum polysaccharide levels. The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals.
Mavrogiorgos
Nikolaos
N
Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Zaragoza
Oscar
O
Casadevall
Arturo
A
Nosanchuk
Joshua D
JD
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000188:drug therapy*; D003455:Cryptococcus neoformans; D005260:Female; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000097:blood; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011134:Polysaccharides; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole