title: Rough sheets and smooth tubules.
abstract: The endoplasmic reticulum (ER) has distinct morphological domains composed of sheets and tubules, which differ in their characteristic membrane curvature. Key proteins may drive the formation of these structural morphologies, which in turn could generate the rough and smooth functional domains of the ER.
authors.affiliation: Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Gia K
authors.initials: GK
authors.lastname: Voeltz
authors.forename: Tom A
authors.initials: TA
authors.lastname: Rapoport
mesh_terms: D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism / Q000648:ultrastructure; D018870:Endoplasmic Reticulum, Rough / Q000378:metabolism* / Q000648:ultrastructure*; D018871:Endoplasmic Reticulum, Smooth / Q000378:metabolism* / Q000648:ultrastructure*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism / Q000648:ultrastructure; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D014176:Protein Biosynthesis / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism; D013256:Steroids / Q000096:biosynthesis
chemical_list: D013256:Steroids