title: Spatiotemporal Bayesian analysis of Lyme disease in New York state, 1990-2000.
abstract: Mapping ordinarily increases our understanding of nontrivial spatial and temporal heterogeneities in disease rates. However, the large number of parameters required by the corresponding statistical models often complicates detailed analysis. This study investigates the feasibility of a fully Bayesian hierarchical regression approach to the problem and identifies how it outperforms two more popular methods: crude rate estimates (CRE) and empirical Bayes standardization (EBS). In particular, we apply a fully Bayesian approach to the spatiotemporal analysis of Lyme disease incidence in New York state for the period 1990-2000. These results are compared with those obtained by CRE and EBS in Chen et al. (2005). We show that the fully Bayesian regression model not only gives more reliable estimates of disease rates than the other two approaches but also allows for tractable models that can accommodate more numerous sources of variation and unknown parameters.
authors.affiliation: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Howard H
authors.initials: HH
authors.lastname: Stratton
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Caraco
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: White
mesh_terms: D001499:Bayes Theorem; D005843:Geography; D006801:Humans; D015994:Incidence; D008193:Lyme Disease / Q000453:epidemiology*; D008954:Models, Biological; D009518:New York / Q000453:epidemiology; D012044:Regression Analysis; D013997:Time Factors