title: Periosteal osteosarcoma: long-term outcome and risk of late recurrence.
abstract: The long-term outcome of periosteal osteosarcoma is not well defined. We sought to examine the disease-specific survival and risk of late recurrence or dedifferentiation in a cohort of 29 patients with average of 15.8 years followup. Disease-free survival was 83%, with five patients dying of disease at an average of 26 months after presentation. Survival was similar with respect to anatomic location, pathologic grade, and limb-salvage resection. All instances of local recurrence, metastatic disease, and death occurred within 3 years after presentation. There were no instances of dedifferentiation. Long-term disease-free survival is possible after resection of the local recurrence. Limb-salvage therapy seems to offer survival equivalent to amputation, and there does not seem to be a substantial risk of late recurrence, dedifferentiation, or disease progression.
authors.affiliation: Departments of Orthopedic Surgery, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Rose
authors.forename: Ian D
authors.initials: ID
authors.lastname: Dickey
authors.forename: Doris E
authors.initials: DE
authors.lastname: Wenger
authors.forename: Krishnan K
authors.initials: KK
authors.lastname: Unni
authors.forename: Franklin H
authors.initials: FH
authors.lastname: Sim
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000473:pathology / Q000601:surgery*; D010521:Periosteum