title: Ocular surface sealants and adhesives.
abstract: Tissue adhesives, both synthetic and biologic, have a long history of use in ophthalmology. Cyanoacrylate-based glues have traditionally been the most widely used glues for various purposes. They have been specially useful for treating corneal perforations and have had significantly improved long-term outcomes. More recently, fibrin-based glues have gained a major role as a suture substitute for attaching biologic tissues and as surface sealants. The literature supports expanded use of fibrin glue in this fashion. Other new agents, such as polyethyelene glycols, have been underutilized and hold promise, especially as surface protectants. Numerous other glues are being developed and show promise as ocular surface sealants and protective membranes. Advances in knowledge about tissue adhesives are leading to more effective and efficient ophthalmic care.
authors.affiliation: Department of Ophthalmology, University of Florida, Gainesville, Florida 32610, USA. Subirb@yahoo.com
authors.forename: Subir Singh
authors.initials: SS
authors.lastname: Bhatia
mesh_terms: D000269:Adhesives / Q000627:therapeutic use*; D003315:Cornea / Q000601:surgery; D003316:Corneal Diseases / Q000209:etiology / Q000601:surgery*; D065306:Corneal Injuries; D006801:Humans; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000269:Adhesives; D014014:Tissue Adhesives