title: Minocycline-induced vasculitis fulfilling the criteria of polyarteritis nodosa.
abstract: A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP). Neither myeloperoxidase- nor proteinase-3-antineutrophil cytoplasmic antibody was positive. These manifestations met the American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Stopping minocycline led to amelioration of symptoms and normalization of CRP level. To our knowledge, this is the second case of minocycline-induced vasculitis satisfying the criteria. Differential diagnosis for drug-induced disease is invaluable even for patients with classical polyarteritis nodosa.
authors.affiliation: Division of Allergy and Clinical Immunology, National Hospital Organization, Osaka-Minami Medical Center, 2-1 Kido-higashi, Kawachinagano, 586-8521, Japan. kataday@omh.hosp.go.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Katada
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Harada
authors.forename: Naoto
authors.initials: N
authors.lastname: Azuma
authors.forename: Kengo
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Haruko
authors.initials: H
authors.lastname: Terada
authors.forename: Eriko
authors.initials: E
authors.lastname: Kudo
authors.forename: Masaru
authors.initials: M
authors.lastname: Ishii
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamane
authors.forename: Suguru
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Shiro
authors.initials: S
authors.lastname: Ohshima
authors.forename: Toru
authors.initials: T
authors.lastname: Mima
authors.forename: Toshio
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Saeki
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D018771:Arthralgia / Q000139:chemically induced; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D010292:Paresthesia / Q000139:chemically induced; D010488:Polyarteritis Nodosa / Q000139:chemically induced*; D011565:Psoriasis / Q000188:drug therapy*; D013737:Testis
chemical_list: D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein; D008911:Minocycline