title: Estimation of relative bioavailability of lead in soil and soil-like materials using young Swine.
abstract: In this article we summarize the results of a series of studies that measured the relative bioavailability (RBA) of lead in a variety of soil and soil-like test materials. Reference material (Pb acetate) or Pb-contaminated soils were administered orally to juvenile swine twice a day for 15 days. Blood samples were collected from each animal at multiple times during the course of the study, and samples of liver, kidney, and bone were collected at sacrifice. All samples were analyzed for Pb. We estimated the RBA of a test material by fitting mathematical models to the dose-response curves for each measurement end point and finding the ratio of doses that gave equal responses. The final RBA for a test material is the simple average of the four end point-specific RBA values. Results from 19 different test materials reveal a wide range of RBA values across different exposure materials, ranging from 6 to 105%. This variability in RBA between different samples highlights the importance of reliable RBA data to help improve risk assessments for Pb in soil. Although the RBA value for a sample depends on the relative amounts of the different chemical and physical forms of Pb present, data are not yet adequate to allow reliable quantitative predictions of RBA from chemical speciation data alone.
authors.affiliation: Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.
authors.forename: Stan W
authors.initials: SW
authors.lastname: Casteel
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Weis
authors.forename: Gerry M
authors.initials: GM
authors.lastname: Henningsen
authors.forename: William J
authors.initials: WJ
authors.lastname: Brattin
mesh_terms: D000465:Algorithms; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D001800:Blood Specimen Collection; D001835:Body Weight / Q000502:physiology; D004032:Diet; D004305:Dose-Response Relationship, Drug; D007854:Lead / Q000493:pharmacokinetics*; D008297:Male; D011786:Quality Control; D012015:Reference Standards; D015203:Reproducibility of Results; D012989:Soil Pollutants / Q000493:pharmacokinetics*; D013552:Swine; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D012989:Soil Pollutants; D007854:Lead