title: Current concepts in the pathogenesis and management of exfoliation syndrome and exfoliative glaucoma.
abstract: Exfoliative glaucoma is a common, sight-threatening disease that develops as a consequence of exfoliation syndrome. There are important differences in the clinical appearance, course, and prognosis of exfoliative glaucoma versus primary open-angle glaucoma. At the clinical, biochemical, and cellular levels, exfoliative glaucoma is a distinct entity, with an intriguing mechanism of development and numerous systemic manifestations that require further elucidation. The subtlety of clinical signs results in the diagnosis of exfoliative glaucoma often being overlooked and resulting in less-than-ideal management. We provide an overview of recent studies investigating the medical, laser, and surgical therapy of exfoliative glaucoma, with a focus on innovative approaches that may slow the progression of, or even prevent, the development of exfoliation syndrome and exfoliative glaucoma.
authors.affiliation: Glaucoma Unit, A University Department of Ophthalmology, AHEPA Hospital, 1 Kyriakidi Str., Thessaloniki 546 36, Greece. konstas@med.auth.gr
authors.forename: Anastasios G P
authors.initials: AG
authors.lastname: Konstas
authors.forename: Sevasti
authors.initials: S
authors.lastname: Tsironi
authors.forename: Robert
authors.initials: R
authors.lastname: Ritch
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D017889:Exfoliation Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D018463:Filtering Surgery / Q000379:methods*; D005901:Glaucoma / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D011379:Prognosis; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents