[Tumor stem cells--a possible scenario].
More and more evidence support that tumors arise from somatic stem cells or from cells, either progenitors or differentiated ones, with the properties of stemness. It is a question whether all tumor cells have the capacity for self renewal and unlimited growth or only a fraction of them, i.e. the tumor stem cells. The concept is challenging, since the existence of tumor stem cells has an important practical consequence: only stem cells should be removed or stopped in order to control the tumor, while the other cells have temporary proliferative capacity.
Kopper
László
L
I. sz. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Altalános Orvostudományi Kar, Budapest, Hungary. kopper@korb1.sote.hu
Hajdú
Melinda
M
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005260:Female; D053823:Hedgehog Proteins; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D008297:Male; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D051880:Receptors, Notch / Q000378:metabolism; D013234:Stem Cells; D015534:Trans-Activators / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism
D053823:Hedgehog Proteins; D051880:Receptors, Notch; D015534:Trans-Activators; D051153:Wnt Proteins