title: Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks.
abstract: Several lines of evidence suggest that anxiety disorders have a strong genetic component, but so far only few susceptibility genes have been identified. There is preclinical and clinical evidence for a dysregulation of the central gamma-aminobutyric acid (GABA)-ergic tone in the pathophysiology of anxiety disorders. Diazepam binding inhibitor (DBI) has been suggested to play a pivotal role in anxiety disorders through direct and indirect, i.e. via synthesis of neuroactive steroids, modulation of GABA(A) receptor function. These findings suggest that the DBI gene can be postulated as a candidate for a genetic association study in this disorder. Thus, single nucleotide polymorphisms (SNPs) of the DBI gene were investigated for putative disease associations in a German sample of anxiety disorder patients suffering from panic attacks and matched controls. We were able to detect a significant association between a non-synonymous coding variant of DBI with anxiety disorders with panic attacks. The rare allele of this polymorphism was more frequent in controls than in patients (OR=0.43; 95% CI: 0.19-0.95). In conclusion, these results suggest a central role of DBI genetic variants in the susceptibility for the development of anxiety disorders that are characterized by the occurrence of panic attacks.
authors.affiliation: Max Planck Institute of Psychiatry, Munich 80804, Germany.
authors.forename: Christoph K
authors.initials: CK
authors.lastname: Thoeringer
authors.forename: Elisabeth B
authors.initials: EB
authors.lastname: Binder
authors.forename: Daria
authors.initials: D
authors.lastname: Salyakina
authors.forename: Angelika
authors.initials: A
authors.lastname: Erhardt
authors.forename: Marcus
authors.initials: M
authors.lastname: Ising
authors.forename: Paul G
authors.initials: PG
authors.lastname: Unschuld
authors.forename: Nikola
authors.initials: N
authors.lastname: Kern
authors.forename: Susanne
authors.initials: S
authors.lastname: Lucae
authors.forename: Tanja M
authors.initials: TM
authors.lastname: Brueckl
authors.forename: Marianne B
authors.initials: MB
authors.lastname: Mueller
authors.forename: Brigitte
authors.initials: B
authors.lastname: Fuchs
authors.forename: Benno
authors.initials: B
authors.lastname: Puetz
authors.forename: Roselind
authors.initials: R
authors.lastname: Lieb
authors.forename: Manfred
authors.initials: M
authors.lastname: Uhr
authors.forename: Florian
authors.initials: F
authors.lastname: Holsboer
authors.forename: Bertram
authors.initials: B
authors.lastname: Mueller-Myhsok
authors.forename: Martin E
authors.initials: ME
authors.lastname: Keck
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D000483:Alleles; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D015897:Comorbidity; D026261:Diazepam Binding Inhibitor; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D005858:Germany; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D026261:Diazepam Binding Inhibitor; D005819:Genetic Markers