Composition, enantiomeric distribution, and antibacterial activity of the essential oil of Achillea ligustica All. from Corsica.
The essential oil of Achillea ligustica from Corsica was investigated by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 82 compounds representing 94.0% of the oil were tentatively identified. The main constituents were the camphane derivatives, representing >30% (camphor, 21.3%; borneol, 6.2%; bornyl acetate, 3.5%) of the whole oil, and santolina alcohol (19.3%). The enantiomeric distribution of 8 chiral constituents was determined by GC-MS using two enantioselective stationary phases (DIME-beta-CD and Lipodex-E). Racemic santolina alcohol, required for optimization of the enantioselective GC conditions, was prepared by an original two-step synthesis from 2,5-dimethylhexa-2,4-diene. The whole essential oil was tested for its antibacterial activity against a wide range of bacteria using a paper disk method. The results show a promising activity against Streptomyces species.
Filippi
Jean-Jacques
JJ
LCMBA, UMR CNRS 6001, Université de Nice-Sophia Antipolis, Parc Valrose, F-06108 Nice Cedex 2, France. jfilippi@uni-hohenheim.de
Lanfranchi
Don-Antoine
DA
Prado
Soizic
S
Baldovini
Nicolas
N
Meierhenrich
Uwe J
UJ
D031162:Achillea / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002849:Chromatography, Gas; D005602:France; D008401:Gas Chromatography-Mass Spectrometry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism; D013302:Streptomyces / Q000187:drug effects
D000900:Anti-Bacterial Agents; D009822:Oils, Volatile