Functional responses of bone cells to thrombin.
Cells responsible for the formation and maintenance of bone express thrombin-responsive members of the protease-activated receptor family of G protein-coupled receptors. Thrombin has been shown to elicit a number of functional responses in these cells, including proliferation and cytokine production in osteoblasts. Many, but not all, of the effects of thrombin on bone cells are initiated by activation of protease-activated receptor-1. A combination of in vitro observations and results of in vivo studies in protease-activated receptor-1-null mice suggest that thrombin plays multiple roles in the early stages of bone healing.
Pagel
Charles N
CN
School of Veterinary Science, University of Melbourne, Parkville, Victoria 3010, Australia. cpagel@unimelb.edu.au
Sivagurunathan
Sutharshani
S
Loh
Lay Hoon
LH
Tudor
Elizabeth M
EM
Pike
Robert N
RN
Mackie
Eleanor J
EJ
D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D044463:Receptor, PAR-1 / Q000187:drug effects / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*
D044463:Receptor, PAR-1; D013917:Thrombin