[Serotonin transporter gene polymorphism in slow transit constipation].
OBJECTIVE
To investigate the association between the polymorphism of serotonin transporter gene-linked polymorphic region(5-HTTLPR) and slow transit constipation(STC).


METHODS
Polymerase chain reaction was used to assess 5-HTTLPR polymorphism of SERT gene in 54 patients with STC and 100 healthy controls.


RESULTS
The frequencies of serotonin transporter short/short(S/S) and allele S genotypes were significantly higher in STC patients than those in controls(72.2% vs 50.0%; 83.3% vs 72.5%; both P< 0.05). There were no significant differences in 5-HTTLPR polymorphism respectively between the two groups according to gender and age(less than 45 and more than 45 years old). The frequency of S/S genotype was higher in the patients with less than 40% of the ingested markers evacuated within 72 h than those with more than 40% evacuated(71.7% vs 42.6%, P< 0.05).


CONCLUSIONS
The presence of 5-HTTLPR allele S may contribute to the pathogenesis of STC.
Ding
Jian-hua
JH
Department of Colorectal Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. junyi93@yahoo.com.cn
Fu
Chuan-gang
CG
Zhao
Rong-hua
RH
Meng
Rong-gui
RG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002908:Chronic Disease; D003248:Constipation / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
D050486:Serotonin Plasma Membrane Transport Proteins