title: Serum androgen levels in black, Hispanic, and white men.
abstract: BACKGROUND
  Racial/ethnic differences in androgen levels could account for differences in prostate cancer risk, body composition, and bone loss.
  
  
  OBJECTIVE
  The objective of the study was to investigate racial/ethnic variations in testosterone, bioavailable testosterone, dihydrotestosterone (DHT), SHBG, and dehydroepiandrosterone sulfate (DHEAS) levels.
  
  
  METHODS
  The Boston Area Community Health (BACH) Survey was a multistage stratified cluster random sample, recruiting from 2002 to 2005.
  
  
  METHODS
  The study was a community-based sample of Boston.
  
  
  METHODS
  Participants included black, Hispanic, or white individuals, aged 30-79 yr, competent to sign informed consent and literate in English/Spanish. Of 2301 men recruited, 1899 provided blood samples (538 black, 651 Hispanic, 710 white).
  
  
  METHODS
  Intervention consisted of data obtained during in-person at-home interview, conducted by a bilingual phlebotomist/interviewer.
  
  
  METHODS
  Testosterone, bioavailable testosterone, DHT, DHT to testosterone ratio, SHBG, and DHEAS were measured.
  
  
  RESULTS
  With or without adjustment for covariates, there were no significant differences in testosterone, bioavailable testosterone, or SHBG levels by race/ethnicity. DHEAS levels differed by race/ethnicity before covariate adjustment; after adjustment this difference was attenuated. Before adjustment, DHT and DHT to testosterone ratios did not significantly differ by racial/ethnic group. After adjustment, there was evidence of racial/ethnic differences in DHT (P = 0.047) and DHT to testosterone (P = 0.038) levels. Black men had higher DHT levels and DHT to testosterone ratios than white and Hispanic men.
  
  
  CONCLUSIONS
  Because there are no racial/ethnic differences in testosterone levels, normative ranges need not be adjusted by race/ethnicity for androgen deficiency diagnosis for men aged 30-79 yr. Further investigation is needed to determine whether differences in DHT levels and DHT to testosterone ratio can help explain racial/ethnic variations in prostate cancer incidence, body composition, and bone mass.
authors.affiliation: New England Research Institutes, Watertown, Massachusetts 02472, USA. hlitman@neriscience.com
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Litman
authors.forename: Shalender
authors.initials: S
authors.lastname: Bhasin
authors.forename: Carol L
authors.initials: CL
authors.lastname: Link
authors.forename: Andre B
authors.initials: AB
authors.lastname: Araujo
authors.forename: John B
authors.initials: JB
authors.lastname: McKinlay
mesh_terms: D000328:Adult; D001741:Black or African American; D017677:Age Distribution; D000368:Aged; D000728:Androgens / Q000097:blood*; D001900:Boston / Q000208:ethnology; D003625:Data Collection; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D013196:Dihydrotestosterone / Q000097:blood; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D044465:White People
chemical_list: D000728:Androgens; D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate