title: Synthesis and neuroprotective effects of serofendic acid analogues.
abstract: Analogues of serofendic acid were prepared and their protective effects against L-glutamate (Glu)-induced neurotoxicity were examined using primary cultures of rat cortical neurons. Some analogues exhibited similar neuroprotective activity to that of serofendic acid.
authors.affiliation: Tsukuba Research Laboratories, Eisai Co. Ltd, Tsukuba-Shi 300-2635, Japan. t-terauchi@hhc.eisai.co.jp
authors.forename: Taro
authors.initials: T
authors.lastname: Terauchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Doko
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yonaga
authors.forename: Akiharu
authors.initials: A
authors.lastname: Kajiwara
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Niidome
authors.forename: Ryota
authors.initials: R
authors.lastname: Taguchi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kume
authors.forename: Akinori
authors.initials: A
authors.lastname: Akaike
authors.forename: Hachiro
authors.initials: H
authors.lastname: Sugimoto
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D018698:Glutamic Acid / Q000009:adverse effects; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000138:chemical synthesis*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D004224:Diterpenes; D018696:Neuroprotective Agents; C452642:serofendic acid; D018698:Glutamic Acid