title: Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo 1, 06123 Perugia, Italy. rp@unipg.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Pellicciari
authors.forename: Rosa C
authors.initials: RC
authors.lastname: Rizzo
authors.forename: Gabriele
authors.initials: G
authors.lastname: Costantino
authors.forename: Maura
authors.initials: M
authors.lastname: Marinozzi
authors.forename: Laura
authors.initials: L
authors.lastname: Amori
authors.forename: Paolo
authors.initials: P
authors.lastname: Guidetti
authors.forename: Hui-Qiu
authors.initials: HQ
authors.lastname: Wu
authors.forename: Robert
authors.initials: R
authors.lastname: Schwarcz
mesh_terms: D000613:Aminobutyrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007737:Kynurenine / Q000378:metabolism*; D051381:Rats; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology*; D000637:Transaminases / Q000037:antagonists & inhibitors*; D014364:Tryptophan / Q000378:metabolism*
chemical_list: C515021:4-(ethylsulfonyl)benzoylalanine; D000613:Aminobutyrates; D004791:Enzyme Inhibitors; D013450:Sulfones; D007737:Kynurenine; D014364:Tryptophan; D000637:Transaminases; C021481:kynurenine-oxoglutarate transaminase