title: Fluostatins C-E, novel members of the fluostatin family produced by Streptomyces strain Acta 1383.
abstract: Three new members of the fluostatin family, fluostatins C-E, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Baur
authors.forename: Jörg
authors.initials: J
authors.lastname: Niehaus
authors.forename: Amalia D
authors.initials: AD
authors.lastname: Karagouni
authors.forename: Efstathios A
authors.initials: EA
authors.lastname: Katsifas
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Chalkou
authors.forename: Christos
authors.initials: C
authors.lastname: Meintanis
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Jones
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Alan C
authors.initials: AC
authors.lastname: Ward
authors.forename: Winfried
authors.initials: W
authors.lastname: Beil
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schneider
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005449:Fluorenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D005449:Fluorenes; C512873:fluostatin C; C512874:fluostatin D; C512875:fluostatin E