[The role of nitric oxide in physiology and pathogenesis of ocular diseases].
Nitric oxide (NO) is a gas with diverse biological activities produced from arginine by nitric oxide synthetase (NOS). The loss of retinal ganglion cells is a hallmark of many ophthalmic diseases including glaucoma, retinal ischemia due to central artery occlusion and anterior ischemic optic neuropathy. It may well be significant in optic neuritis, optic nerve, trauma and AIDS. NO appears to be involved in the regulation of intraocular pressure, in the modulation of ocular blood flow and in apoptosis. This article gives a short and simplified overview of the biochemistry of NO and its role in physiology and pathogenesis of ocular diseases.
Komaszyło
Katarzyna
K
Kliniki Okulistyki Akademii Medycznej w Bialymstoku.
Zalewska
Renata
R
Mariak
Zofia
Z
Wiśniewska
Róza Julia
RJ
D005128:Eye Diseases / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism
D009569:Nitric Oxide; D018698:Glutamic Acid; D019001:Nitric Oxide Synthase