title: Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function.
abstract: Both hypoxia and hyperoxia have major effects on cardiovascular function. However, both states affect ventilation and many previous studies have not controlled CO(2) tension. We investigated whether hemodynamic effects previously attributed to modified O(2) tension were still apparent under isocapnic conditions. In eight healthy men, we studied blood pressure (BP), heart rate (HR), cardiac index (CI), systemic vascular resistance index (SVRI) and arterial stiffness (augmentation index, AI) during 1 h of hyperoxia (mean end-tidal O(2) 79.6 +/- 2.0%) or hypoxia (pulse oximeter oxygen saturation 82.6 +/- 0.3%). Hyperoxia increased SVRI (18.9 +/- 1.9%; P < 0.001) and reduced HR (-10.3 +/- 1.0%; P < 0.001), CI (-10.3 +/- 1.7%; P < 0.001), and stroke index (SI) (-7.3 +/- 1.3%; P < 0.001) but had no effect on AI, whereas hypoxia reduced SVRI (-15.2 +/- 1.2%; P < 0.001) and AI (-10.7 +/- 1.1%; P < 0.001) and increased HR (18.2 +/- 1.2%; P < 0.001), CI (20.2 +/- 1.8%; P < 0.001), and pulse pressure (13.2 +/- 2.3%; P = 0.02). The effects of hyperoxia on CI and SVRI, but not the other hemodynamic effects, persisted for up to 1 h after restoration of air breathing. Although increased oxidative stress has been proposed as a cause of the cardiovascular response to altered oxygenation, we found no significant changes in venous antioxidant or 8-iso-prostaglandin F(2alpha) levels. We conclude that both hyperoxia and hypoxia, when present during isocapnia, cause similar changes in cardiovascular function to those described with poikilocapnic conditions.
authors.affiliation: Dept. of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary, Edinburgh EH16 4SA, UK.
authors.forename: Alastair J
authors.initials: AJ
authors.lastname: Thomson
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Drummond
authors.forename: W Stephen
authors.initials: WS
authors.lastname: Waring
authors.forename: David J
authors.initials: DJ
authors.lastname: Webb
authors.forename: Simon R J
authors.initials: SR
authors.lastname: Maxwell
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood*; D002302:Cardiac Output; D018592:Cross-Over Studies; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010100:Oxygen / Q000097:blood*; D016037:Single-Blind Method; D013997:Time Factors; D014655:Vascular Resistance
chemical_list: D000975:Antioxidants; D002245:Carbon Dioxide; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D010100:Oxygen