title: Frequency of elemental events of intracellular Ca(2+) dynamics.
abstract: The dynamics of intracellular Ca(2+) is driven by random events called Ca(2+) puffs, in which Ca(2+) is liberated from intracellular stores. We show that the emergence of Ca(2+) puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca(2+) puffs has to account for the discrete character of the Ca(2+) release sites and does not permit a continuous description of the number of open channels.
authors.affiliation: Hahn-Meitner Institut, Abteilung Theorie, Glienicker Str. 100, D-14109 Berlin, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Thul
authors.forename: M
authors.initials: M
authors.lastname: Falcke
mesh_terms: D002118:Calcium / Q000502:physiology*; D020013:Calcium Signaling; D042541:Intracellular Space / Q000378:metabolism; D008954:Models, Biological
chemical_list: D002118:Calcium