title: [Psychobiological significance of antipsychotics in multi-high dose drug therapy for schizophrenia].
abstract: In this session, the development of antipsychotics and 'atypicality' were discussed firstly. Various concepts regarding 'atypicality' had the meaning of optimal modulation of dopamine. Then, the key role of dopamine for psychotic symptoms and the question how antipsychotics should work for managing those symptoms were treated by introducing the theories by Kapur and Yagi. And from all these reasons, it came to the conclusion that megadose-polypharmacy treatment should be avoided.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D000075202:Contraindications; D004298:Dopamine / Q000502:physiology; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006801:Humans; D011613:Psychotherapy; D012559:Schizophrenia / Q000628:therapy*
chemical_list: D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D004298:Dopamine