title: Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma.
abstract: We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations.
authors.affiliation: Department of Epidemiology, NUTRIM, Maastricht University, PO Box 616, Maastricht 6200 MD, The Netherlands.
authors.forename: B A C
authors.initials: BA
authors.lastname: van Dijk
authors.forename: L J
authors.initials: LJ
authors.lastname: Schouten
authors.forename: E
authors.initials: E
authors.lastname: Oosterwijk
authors.forename: C A
authors.initials: CA
authors.lastname: Hulsbergen-van de Kaa
authors.forename: L A L M
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: R A
authors.initials: RA
authors.lastname: Goldbohm
authors.forename: J A
authors.initials: JA
authors.lastname: Schalken
authors.forename: P A
authors.initials: PA
authors.lastname: van den Brandt
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics*
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein