title: Treatment of acute post-surgical infection of joint arthroplasty.
abstract: The best antibiotic regimen for acute prosthetic joint infection, treated without removal of the implant, has not been well-defined. This study describes the use of a protocol based on oral rifampicin combinations to treat 47 cases that were followed prospectively for a 2-year period. The regimen used most commonly was levofloxacin 500 mg/24 h plus rifampicin 600 mg/24 h for a mean duration of 2.7 +/- 1 months. The cure rate was 76.9%, and the only independent risk-factor associated with treatment failure was infection caused by methicillin-resistant Staphylococcus aureus or Enterococcus spp. (OR 17.6, p 0.003). Overall, the results suggested that use of oral antibiotics, including rifampicin, for 2-3 months was a good treatment option.
authors.affiliation: Department of Infectious Diseases, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain. asoriano@clinic.ub.es
authors.forename: A
authors.initials: A
authors.lastname: Soriano
authors.forename: S
authors.initials: S
authors.lastname: García
authors.forename: G
authors.initials: G
authors.lastname: Bori
authors.forename: M
authors.initials: M
authors.lastname: Almela
authors.forename: X
authors.initials: X
authors.lastname: Gallart
authors.forename: F
authors.initials: F
authors.lastname: Macule
authors.forename: J
authors.initials: J
authors.lastname: Sierra
authors.forename: J A
authors.initials: JA
authors.lastname: Martínez
authors.forename: S
authors.initials: S
authors.lastname: Suso
authors.forename: J
authors.initials: J
authors.lastname: Mensa
mesh_terms: D000208:Acute Disease; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D003646:Debridement; D004359:Drug Therapy, Combination; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006095:Gram-Positive Cocci / Q000187:drug effects; D006801:Humans; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin; D012293:Rifampin