C-type natriuretic peptide is specifically augmented by pituitary adenylate cyclase-activating polypeptide in rat astrocytes.
In rat-cultured astrocytes, pituitary adenylate cyclase-activating polypeptide (PACAP) activates gene expression and secretion of C-type natriuretic peptide (CNP) in a dose- and time-dependent manner. These results suggest that PACAP might be involved in the regulation of CNP biosynthesis in astrocytes.
Fujikawa
Kohsho
K
Department of Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, 890-8544, Japan.
Nagayama
Tetsuya
T
Inoue
Kazuhiko
K
Minamino
Naoto
N
Kangawa
Kenji
K
Niiro
Masaki
M
Miyata
Atsuro
A
D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000378:metabolism*; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D020098:Natriuretic Peptide, C-Type / Q000235:genetics* / Q000378:metabolism; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000494:pharmacology*; D051381:Rats
D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D020098:Natriuretic Peptide, C-Type