New efficient organic activators for highly enantioselective reduction of aromatic ketones by trichlorosilane.
[reaction: see text] Aryl ketones were reduced to the corresponding alcohols with excellent enantioselectivity (up to 99.7% ee) by Cl3SiH in the presence of a catalytic amount of N-formyl-alpha'-(2,4,6-triethylphenyl)-L-proline as an activator. Both carboxyl group at the alpha-position of the activator and 2,4,6-triethylphenyl group at the alpha'-position were critical for the high enantioselectivity.
Matsumura
Yoshihiro
Y
Graduate School of Biomedical Sciences, Nagasaki University,Bunkyo-machi, Nagasaki 852-8521, Japan. matumura@net.nagasaki-u.ac.jp
Ogura
Kanako
K
Kouchi
Yoshimi
Y
Iwasaki
Fumiaki
F
Onomura
Osamu
O