Uterine tumor resembling ovarian sex cord tumors in a patient using tamoxifen: report of a case and review of literature.
Increasing number of uterine malignancies have been reported in breast cancer patients using tamoxifen. Most of these are endometrial adenocarcinomas. However, only a few cases of endometrial stromal sarcomas have been reported to be linked with tamoxifen usage. A 58-year-old postmenopausal women who had been using tamoxifen for 4 years after a surgery for breast cancer is presented with chronic pelvic pain. Preoperative investigations were indicative of a uterine myoma so that a standard total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Postoperative histologic diagnosis was a uterine tumor resembling ovarian sex cord tumors, which is an exceedingly rare entity itself. The present case is the first designated diagnosis of this rare tumor, with a possible association of tamoxifen usage.
Oztekin
O
O
2nd Obstetrics and Gynecology Clinic, Department of Gynecologic Oncology and Pathology Clinic, Ataturk Education and Training Hospital, Izmir, Turkey. ozeroztekin@gmail.com
Soylu
F
F
Yigit
S
S
Sarica
E
E
D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D010052:Ovariectomy; D017698:Postmenopause; D018312:Sex Cord-Gonadal Stromal Tumors / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D013629:Tamoxifen / Q000009:adverse effects*; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen