Auditory perception and attention as reflected by the brain event-related potentials in children with Asperger syndrome.
OBJECTIVE
Language development is delayed and deviant in individuals with autism, but proceeds quite normally in those with Asperger syndrome (AS). We investigated auditory-discrimination and orienting in children with AS using an event-related potential (ERP) paradigm that was previously applied to children with autism.


METHODS
ERPs were measured to pitch, duration, and phonetic changes in vowels and to corresponding changes in non-speech sounds. Active sound discrimination was evaluated with a sound-identification task.


RESULTS
The mismatch negativity (MMN), indexing sound-discrimination accuracy, showed right-hemisphere dominance in the AS group, but not in the controls. Furthermore, the children with AS had diminished MMN-amplitudes and decreased hit rates for duration changes. In contrast, their MMN to speech pitch changes was parietally enhanced. The P3a, reflecting involuntary orienting to changes, was diminished in the children with AS for speech pitch and phoneme changes, but not for the corresponding non-speech changes.


CONCLUSIONS
The children with AS differ from controls with respect to their sound-discrimination and orienting abilities.


CONCLUSIONS
The results of the children with AS are relatively similar to those earlier obtained from children with autism using the same paradigm, although these clinical groups differ markedly in their language development.
Lepistö
T
T
Cognitive Brain Research Unit, Department of Psychology, P.O. Box 9, FIN-00014 University of Helsinki, Finland. tuulia.lepisto@helsinki.fi
Silokallio
S
S
Nieminen-von Wendt
T
T
Alku
P
P
Näätänen
R
R
Kujala
T
T
D000161:Acoustic Stimulation; D020817:Asperger Syndrome / Q000503:physiopathology*; D001288:Attention / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male