[A case of gastric cancer with abdominal wall invasion treated by weekly low-dose paclitaxel therapy].
Here we report a case of gastric cancer with diffuse abdominal wall invasion treated with weekly low-dose paclitaxel therapy. A 62-year-old male visited our hospital because of abdominal distention, prepubic tumor,and testicular hydrocele. Computed tomography revealed diffuse swelling of the abdominal wall and hydronephrosis of the right kidney. Upper gastrointestinal endoscopy demonstrated type 3' advanced gastric cancer. Pathological diagnosis of both gastric tumor and abdominal wall biopsy specimens was poorly-differentiated adenocarcinoma containing signet ring cell carcinoma. Low-dose paclitaxel (90 mg/body) was given once a week for 3 weeks. Abdominal wall swelling like cuirass disappeared after 2 courses of low-dose paclitaxel therapy. Nine repeated courses of this regimen have been given until now; the relapse of the abdominal wall invasion has not become apparent, and primary gastric lesion has been a stable disease. Diffuse abdominal wall invasion of gastric cancer like cuirass without ascites is a rare condition, and low-dose paclitaxel was very effective for this condition.
Waguri
Nobuo
N
Dept. of Gastroenterology and Hepatology, Niigata City General Hospital.
Furukawa
Koichi
K
Shobugawa
Kikuko
K
Takizawa
Kazuyoshi
K
Ikeda
Haruo
H
Iwamoto
Yasuhiko
Y
Aiba
Tsuneo
T
Yoneyama
Osamu
O
Igarashi
Kentarou
K
Tsukioka
Satoshi
S
Yabe
Masahiro
M
Kuwabara
Shiro
S
Shibuya
Hiroyuki
H
D034861:Abdominal Wall / Q000473:pathology*; D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D017239:Paclitaxel / Q000008:administration & dosage*; D011860:Radiography, Abdominal; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel