title: Synthesis of gem-difluoromethylenated daidzein analogues and their inhibitory effect on U2OS cell cycle.
abstract: gem-Difluoromethylenated daidzein analogues 2 and 4 were obtained by the insertion reaction of difluorocarbene. A series of alkylated fluorine-containing daidzein analogues 3a-f and 5a-f were synthesized. All the compounds were tested for the inhibitory effect on U2OS cell cycle in vitro. The results showed that 7-octyloxy-3-(4-difluoromethoxyphenyl)-chromen-4-one 5d was the most active inhibitor.
authors.affiliation: College of Chemistry and Chemical Engineering, Donghua University, 2999 Remin Rd. North, Songjiang District, Shanghai 201620, China. wdmeng@dhu.edu.cn
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Meng
authors.forename: Zhi-Hang
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Qing
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Yue-Yue
authors.initials: YY
authors.lastname: Zhang
authors.forename: Hui-Sheng
authors.initials: HS
authors.lastname: Wang
mesh_terms: D000478:Alkylation; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D007202:Indicators and Reagents; D007529:Isoflavones / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D007529:Isoflavones; C004742:daidzein