Giant cell interstitial pneumonia associated with nitrofurantoin.
A case of giant cell interstitial pneumonia (GIF) that occurred in association with exposure to nitrofurantoin is presented. While the diagnosis of GIP is confirmed by histopathology, this diagnosis can be supported by the findings of bizarre multinucleated giant cells (MGC), elevated T lymphocytes, and a low T lymphocyte helper/suppressor ratio in the bronchoalveolar lavage fluid (BALF). Recognition of GIP as a rare manifestation of nitrofurantoin toxicity is important because prompt therapy may be associated with a favorable outcome.
Hargett
Charles William
CW
Division of Pulmonary, Allergy, and Critical Care, Duke University Medical Center, Box 3221, Durham, NC 27710, USA.
Sporn
Thomas A
TA
Roggli
Victor L
VL
Hollingsworth
John W
JW
D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D005260:Female; D015726:Giant Cells; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D009582:Nitrofurantoin / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy
D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin