Synergistic effect of ginger and nifedipine on human platelet aggregation: a study in hypertensive patients and normal volunteers.
In this study, we evaluated the synergistic effect of ginger and nifedipine on anti-platelet aggregation in normal human volunteers and hypertensive patients. The results showed that the percentage of platelet aggregation induced by collagen, ADP and epinephrine in hypertensive patients was larger than that in normal volunteers. Either aspirin or ginger could potentiate the anti-platelet aggregation effect of nifedipine in normal volunteer and hypertensive patients. These results suggested that ginger and nifedipine possessed synergistic effect on anti-platelet aggregation. A combination of 1 g ginger with 10 mg nifedipine per day could be valuable for cardiovascular and cerebrovascular complication due to platelet aggregation.
Young
Haw-Yaw
HY
Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, ROC.
Liao
Jung-Chun
JC
Chang
Yuan-Shiun
YS
Luo
Yen-Lin
YL
Lu
Ming-Chin
MC
Peng
Wen-Huang
WH
D000244:Adenosine Diphosphate / Q000008:administration & dosage / Q000494:pharmacology; D000328:Adult; D003094:Collagen / Q000008:administration & dosage / Q000494:pharmacology; D004357:Drug Synergism; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D020939:Zingiber officinale; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology
D028321:Plant Preparations; D010975:Platelet Aggregation Inhibitors; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D000244:Adenosine Diphosphate; D003094:Collagen; D009543:Nifedipine; D004837:Epinephrine