Histopathologic findings in primary erythromelalgia are nonspecific: special studies show a decrease in small nerve fiber density.
The histopathology of primary erythromelalgia has been poorly characterized. A total of 33 skin biopsy specimens from 29 patients with a diagnosis of primary erythromelalgia were re-examined. Histopathologic findings were nonspecific. Vascular thrombi were not identified. A relative decrease in small nerve fiber density was noted in specimens from 13 of 16 patients.
Davis
Mark D P
MD
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Weenig
Roger H
RH
Genebriera
Joseph
J
Wendelschafer-Crabb
Gwen
G
Kennedy
William R
WR
Sandroni
Paola
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004916:Erythromelalgia / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012867:Skin / Q000294:innervation* / Q000473:pathology*