title: The effect of APOE genotype on clinical phenotype in Alzheimer disease.
abstract: The authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-epsilon4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-epsilon4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-epsilon4 allele.
authors.affiliation: Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. wm.vdflier@vumc.nl
authors.forename: W M
authors.initials: WM
authors.lastname: van der Flier
authors.forename: S N M
authors.initials: SN
authors.lastname: Schoonenboom
authors.forename: Y A L
authors.initials: YA
authors.lastname: Pijnenburg
authors.forename: N C
authors.initials: NC
authors.lastname: Fox
authors.forename: P
authors.initials: P
authors.lastname: Scheltens
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D001057:Apolipoproteins E