title: Total synthesis of (+)-hygrine via asymmetric phase-transfer catalytic alkylation.
abstract: The first enantioselective synthesis of (+)-hygrine (1) is reported. 1 was obtained in 12 steps with 29% overall yield and 97% ee via asymmetric phase-transfer catalytic alkylation and ring-closing metathesis as key steps. The absolute configuration of (+)-hygrine could be directly confirmed as R.
authors.affiliation: Research Institute of Pharmaceutical Science and College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors.forename: Jeong-Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Byeong-Seon
authors.initials: BS
authors.lastname: Jeong
authors.forename: Jin-Mo
authors.initials: JM
authors.lastname: Ku
authors.forename: Sang-sup
authors.initials: SS
authors.lastname: Jew
authors.forename: Hyeung-geun
authors.initials: HG
authors.lastname: Park
mesh_terms: D000478:Alkylation; D002384:Catalysis; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011759:Pyrrolidines; C015946:hygrine