title: [The optimal dosing times of corticoids].
abstract: The therapeutic use of cortisol and its derivatives, anti-inflammatory corticoids, sets delicate problems to resolve because of cortisol's physiological roles and its circadian rhythms. Cortisol and the majority of its derivatives have desirable and undesirable effects that are time-related administration. The chronotherapeutic optimisation to increase desirable effects and safety of corticoids is shown in the treatment of adrenocortical failure, congenital adrenal hyperplasia and asthma. The knowledge of physiological and physiopathological rhythms of asthma permitted to realize oral treatment optimisation by using a number of corticoids. This knowledge puts in a prominent position the advantages of ciclesonide: a new inhaled corticoid. A chronobiologic approach could be used in a classic optimisation which involves a molecule modification and inhalation like routes of administration.
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.
authors.forename: Dorra
authors.initials: D
authors.lastname: Dridi
authors.forename: Mossadok
authors.initials: M
authors.lastname: Ben Attia
authors.forename: Karim
authors.initials: K
authors.lastname: Aouam
authors.forename: Kamel
authors.initials: K
authors.lastname: Bouzouita
authors.forename: Naceur A
authors.initials: NA
authors.lastname: Boughattas
authors.forename: Alain
authors.initials: A
authors.lastname: Reinberg
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D004334:Drug Administration Schedule; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D010507:Periodicity
chemical_list: D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone