title: Application of heavy-ion CT.
abstract: In treatment planning for hadron therapy, information about the relative stopping power in a patient's body is used to calculate the range of incident ions. This information is obtained from computed tomography (CT) images using a conversion table from x-ray CT numbers into stopping powers relative to the stopping power of water. In treatment planning at the National Institute of Radiological Sciences (NIRS), the conversion table has been created based on the polybinary tissue model. However, it has not been fully verified that the model is accurate enough for use in real animal tissues. In order to irradiate heavy ions more precisely in radiotherapy, we have to evaluate the accuracy of the polybinary tissue calibration in animal tissues. We have measured animal tissue samples with a heavy-ion CT (HICT) and an x-ray CT. The x-ray CT image was converted to an image of relative stopping power by using the table derived from the polybinary tissue calibration (polybinary-tissue-model CT (PTCT) image). On the other hand, with HICT, the two-dimensional distribution of relative stopping power can be obtained directly. A comparison between PTCT and HICT images enabled us to verify the accuracy of the conversion table derived from the polybinary tissue calibration. Consequently, it was found that the agreement between the relative stopping powers of PTCT and HICT is 1.6% for fat, muscle and bone.
authors.affiliation: Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi 226-8502, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shinoda
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Kanai
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kohno
mesh_terms: D000818:Animals; D001822:Body Burden; D005528:Foot / Q000000981:diagnostic imaging* / Q000528:radiation effects; D063193:Heavy Ion Radiotherapy; D020450:Heavy Ions; D066298:In Vitro Techniques; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012062:Relative Biological Effectiveness; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000379:methods*