The centrosome cycle.
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and provide a site for concerted regulation of cell cycle progression. While there is diversity in microtubule organizing center structure among eukaryotes, many centrosome components, such as centrin, are conserved. Experimental analysis has provided an outline to describe centrosome duplication, and numerous centrosome components have been identified. Even so, more work is needed to provide a detailed understanding of the interactions between centrosome components and their roles in centrosome function and duplication. Precise duplication of centrosomes once during each cell cycle ensures proper mitotic spindle formation and chromosome segregation. Defects in centrosome duplication or function are linked to human diseases including cancer. Here we provide a multifaceted look at centrosomes with a detailed summary of the centrosome cycle.
Mattison
Christopher P
CP
MCD Biology, University of Colorado-Boulder, 80309-0347, USA.
Winey
Mark
M
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D018385:Centrosome / Q000378:metabolism*; D020090:Chromosome Segregation; D006801:Humans; D022101:Microtubule-Organizing Center / Q000378:metabolism; D008938:Mitosis; D008954:Models, Biological
D018797:Cell Cycle Proteins