title: Diabetes mellitus impairs myocardial oxygen metabolism even in non-infarct-related areas in patients with acute myocardial infarction.
abstract: BACKGROUND
  Although diabetes is associated with poor clinical outcomes after acute myocardial infarction, to date there have been no reports focusing on the myocardial oxygen metabolism in these patients. Thus, we evaluated the myocardial oxygen metabolism in patients with and without diabetes suffering from acute myocardial infarction using carbon-11 acetate positron emission tomography.
  
  
  METHODS
  20 patients (13 diabetic patients [group A] and 7 non-diabetic patients [group B]) underwent carbon-11 acetate positron emission tomography soon after the onset of acute myocardial infarction. The myocardial oxygen metabolism was evaluated within the infarct-related area and in the non infarct-related area. 6 healthy volunteers (group C) and 6 diabetic patients without coronary artery disease (group D) also participated as controls.
  
  
  RESULTS
  There were no significant differences in gender, age, infarct-related artery, peak level of serum creatine phosphokinase, left-ventricular ejection fraction at onset, or the defect severity on myocardial perfusion images between group A and group B. In group A, the clearance rate (Kmono) of carbon-11 acetate in infarct-related area (0.042+/-0.010) was not significantly different from that in group B (0.049+/-0.016). In contrast, Kmono in non infarct-related area in group A (0.059+/-0.010) was significantly lower than that in group B (0.076+/-0.009; p=0.002), group C (0.072+/-0.004; p=0.026) and group D (0.078+/-0.005; p=0.001).
  
  
  CONCLUSIONS
  These data indicate that the myocardial oxygen metabolism even in non infarct-related area in diabetic patients was impaired after the onset of acute myocardial infarction.
authors.affiliation: First Department of Internal Medicine, Faculty of Medical Sciences, Fukui University, 23-3 Shimoaizuki, Matsuoka-cho, Fukui, 910-1193, Japan.
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Toyoda
authors.forename: Akira
authors.initials: A
authors.lastname: Nakano
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujibayashi
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Yonekura
authors.forename: Takanori
authors.initials: T
authors.lastname: Ueda
authors.forename: Jong-Dae
authors.initials: JD
authors.lastname: Lee
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D015897:Comorbidity; D017023:Coronary Angiography / Q000379:methods; D003326:Coronary Circulation / Q000502:physiology*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D015425:Myocardial Reperfusion / Q000379:methods; D010101:Oxygen Consumption / Q000502:physiology*; D049268:Positron-Emission Tomography / Q000379:methods; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D015899:Tomography, Emission-Computed, Single-Photon