[A complex approach to evaluation of human genome instability].
In this study, evaluation of genome instability in individuals exposed to chemical compounds included detection of the genetic polymorphism of some xenobiotic metabolic enzymes (CYP1A1, CYP1E1, PON1, GSTM1, GSTT1), as well as measurement of oxidative state chemiluminescent variables and the level of cytogenetic damage. According to the study, the level of chromosomal aberrations in peripheral blood lymphocytes shows a strong correlation with PON54 left allele and GSTM1 null genotype, and can be described by the polynomial function of blood plasma luminol-dependent chemiluminescence. The frequencies of micronuclei in buccal epithelium displayed a weak association with GSTT1 null genotype.
Revazova
Iu A
IuA
Khripach
L V
LV
Sidorova
I E
IE
Iurchenko
V V
VV
Zykova
I E
IE
D015894:Genome, Human / Q000235:genetics*; D016045:Human Genome Project; D006801:Humans; D016296:Mutagenesis / Q000235:genetics*; D009784:Occupational Diseases / Q000235:genetics*; D016273:Occupational Exposure; D018384:Oxidative Stress / Q000502:physiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D012426:Russia