[Studies on the interaction of the metal complex of hydrazide of podophyllic acid with DNA].
The interaction between the metal complex of hydrazide of podophyllic acid and calf thymus (CT) DNA was studied by using absorption spectra, fluorescence spectra and DNA heat denaturation. It was found that the intensity of the maximal absorption peaks from absorption spectra is weakened in the presence of the metal complex of hydrazide of podophyllic acid compared with that in the absence of the metal complex. All the experimental results show that the intercalation mode was proved to exist between HDPP-Ni complexes and CT DNA.
Wang
Ping-Hong
PH
Province Key Laboratory of Refined Chemistry, Hainan University, Haikou 570228, China.
Zhang
Qi
Q
Wang
Liu-Fang
LF
Song
Yu-Min
YM
Qu
Jian-Qiang
JQ
Liu
Ying-Qian
YQ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; C507546:podophyllic acid; D004247:DNA; C427203:calf thymus DNA; D011034:Podophyllotoxin