The role of 1H magnetic resonance spectroscopy in pre-operative evaluation for epilepsy surgery. A meta-analysis.
OBJECTIVE
We aimed to assess the additional pre-operative value of (1)H MRS in identifying the epileptogenic zone (EZ) for epilepsy surgery by performing a meta-analysis considering publications from 1992 to 2003.


METHODS
From an extensive computer and hand search 22 studies were included. For inclusion, studies had to report post-operative outcome and detailed diagnostic test results for each individual patient. Studies exclusively reporting on patients with brain tumors or on children were excluded.


RESULTS
Great heterogeneity among studies regarding methodological and technical aspects and concerning evaluation and interpretation of data was observed. Only patients with intractable temporal lobe epilepsy were presented. Sixty-four percent of all patients and 72% of patients with good outcome had an ipsilateral MRS abnormality concordant with the EZ. The positive predictive value of all patients with ipsilateral MRS abnormality for good outcome was 82%. An odds ratio weighted by inverse variance showed a 4.891 better chance of seizure free outcome [CI=1.965-12.172; Q=2.748; d.f.=5; critical chi2-value=11.07] in patients with an ipsilateral MRS abnormality when compared to patients with bilateral MRS abnormalities. Data for MRI-negative patients were conflicting. One study stressed a role for MRS in patients with bilateral hippocampal atrophy at MRI.


CONCLUSIONS
MRS still remains a research tool with clinical potential. Our findings indicate the connection of ipsilateral MRS abnormality to good outcome. The ability for prediction of post-operative outcome may depend on the assessed population. Prospective studies limited to non-localized ictal scalp EEG or MRI-negative patients are required for validation of these data.
Willmann
O
O
Department of Neurology, University Hospital Mannheim, University of Heidelberg, Germany.
Wennberg
R
R
May
T
T
Woermann
F G
FG
Pohlmann-Eden
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000601:surgery; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008875:Middle Aged; D016017:Odds Ratio; D011300:Preoperative Care; D016896:Treatment Outcome