title: Characterization of dopaminergic dysfunction in familial progressive supranuclear palsy: an 18F-dopa PET study.
abstract: We analyzed (18)F-dopa PET data from 11 members of kindreds with familial progressive supranuclear palsy (PSP) to characterize their cerebral dopaminergic dysfunction. Three clinically-affected PSP patients showed reduced (18)F-dopa uptake in the striatum, orbitofrontal cortex and amygdala. One asymptomatic subject exhibited progressive putamen dopaminergic dysfunction. 60% of subjects with abnormal (18)F-dopa scans developed PSP subsequently. This is the first in vivo documentation of cortical dopaminergic deficiency in PSP. Reduced striatal (18)F-dopa uptake in susceptible relatives may predict later clinical disease.
authors.affiliation: MRC Clinical Sciences Centre and Division of Neurosciences, Hammersmith Hospital, Imperial College London, United Kingdom.
authors.forename: Y F
authors.initials: YF
authors.lastname: Tai
authors.forename: R L
authors.initials: RL
authors.lastname: Ahsan
authors.forename: J G
authors.initials: JG
authors.lastname: de Yébenes
authors.forename: N
authors.initials: N
authors.lastname: Pavese
authors.forename: D J
authors.initials: DJ
authors.lastname: Brooks
authors.forename: P
authors.initials: P
authors.lastname: Piccini
mesh_terms: D000368:Aged; D000679:Amygdala / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D018450:Disease Progression; D004298:Dopamine / Q000378:metabolism*; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D019965:Neurocognitive Disorders / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D010375:Pedigree; D049268:Positron-Emission Tomography / Q000379:methods; D011237:Predictive Value of Tests; D012016:Reference Values; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology
chemical_list: C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D004298:Dopamine