title: Chimerism in a child with severe combined immunodeficiency: a case report.
abstract: Severe combined immunodeficiency (SCID) represents a group of rare, sometimes fatal, congenital disorders in which there is a combined absence of T-lymphocyte and B-lymphocyte function. Children with SCID die within two years of age, if untreated. The effective treatment for SCID is a hematopoietic stem cell transplantation (HSCT). It has been repeatedly described that in peripheral blood of infants with SCID maternal T cells can be found. Here we report a case of blood chimerism in a one-year-old boy with SCID.
authors.affiliation: C.N.R. Institute for Organ Transplantation and Immunocytology, L'Aquila and Rome Sections, L'Aquila, Italy. a.aureli@itoi.cnr.it
authors.forename: Anna
authors.initials: A
authors.lastname: Aureli
authors.forename: Daniela
authors.initials: D
authors.lastname: Piancatelli
authors.forename: Palmina I
authors.initials: PI
authors.lastname: Monaco
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Ozzella
authors.forename: Angelica
authors.initials: A
authors.lastname: Canossi
authors.forename: Antonina
authors.initials: A
authors.lastname: Piazza
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Isacchi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Caniglia
authors.forename: Domenico
authors.initials: D
authors.lastname: Adorno
mesh_terms: D000483:Alleles; D046528:Chimerism; D006801:Humans; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D016511:Severe Combined Immunodeficiency / Q000235:genetics*