title: Prevalence of patent foramen ovale in migraine patients with and without aura compared with stroke patients. A transcranial Doppler study.
abstract: The aim of this study was to investigate the prevalence of patent foramen ovale (PFO) in a consecutive unselected cohort of migraine patients (with and without aura) and compare it with a group of ischaemic young and elderly stroke patients. One hundred and forty-one migraine patients were compared with 330 stroke patients (130 young patients; 200 elderly patients) selected from our hospital stroke data bank. PFO was assessed with transcranial Doppler sonography with i.v. injection of agitated saline. The prevalence of PFO was 51.7% in migraine with aura (MA) patients, 33.7% in migraine without aura (MoA) patients, 33.8% in young stroke patients and 20.5% in elderly stroke patients (P < 0.001). The prevalence of PFO in cryptogenic stroke in young and elderly stroke patients was, respectively, 41.1% and 25% (P = 0.04). The difference between MA and MoA patients was significant (odds ratio = 2.1). The prevalence of PFO in MA patients is higher than in MoA patients and in young cryptogenic stroke patients.
authors.affiliation: Department of Neurology, The Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brazilia DF, Brazil.
authors.forename: F J
authors.initials: FJ
authors.lastname: Carod-Artal
authors.forename: L
authors.initials: L
authors.lastname: da Silveira Ribeiro
authors.forename: H
authors.initials: H
authors.lastname: Braga
authors.forename: W
authors.initials: W
authors.lastname: Kummer
authors.forename: H M
authors.initials: HM
authors.lastname: Mesquita
authors.forename: A P
authors.initials: AP
authors.lastname: Vargas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D020325:Migraine with Aura / Q000000981:diagnostic imaging / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D017585:Ultrasonography, Doppler, Transcranial / Q000706:statistics & numerical data*