title: Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold.
abstract: A short synthetic protocol leading to HIV-1 protease inhibitors with a tertiary alcohol based transition-state mimicking unit and different P2 side chains has been developed.
authors.affiliation: Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.
authors.forename: Jenny K
authors.initials: JK
authors.lastname: Ekegren
authors.forename: Johan
authors.initials: J
authors.lastname: Gising
authors.forename: Hans
authors.initials: H
authors.lastname: Wallberg
authors.forename: Mats
authors.initials: M
authors.lastname: Larhed
authors.forename: Bertil
authors.initials: B
authors.lastname: Samuelsson
authors.forename: Anders
authors.initials: A
authors.lastname: Hallberg
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D018360:Crystallography, X-Ray; D017320:HIV Protease Inhibitors / Q000737:chemistry*; D015497:HIV-1 / Q000201:enzymology*
chemical_list: D000438:Alcohols; D017320:HIV Protease Inhibitors