title: Repeated dexmedetomidine infusions, a postoperative living-donor liver transplantation patient.
abstract: Here we report on a postoperative living-donor liver transplantation (LDLT) patient who received nightly infusions of dexmedetomidine (DEX), a specific alpha2-adrenergic receptor agonist, to treat agitation and insomnia during an intensive care unit stay. The infusion rate was adjusted according to the Ramsay sedation score. The actual plasma concentrations were higher than the values predicted by RugLoop software package simulation 9 h after the DEX infusion. However, all of the measurements were within the therapeutic range for DEX. Thus, DEX infusion could be safely used in the postoperative LDLT patient by employing a simple consciousness scale.
authors.affiliation: Department of Anesthesiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Terajima
authors.forename: Shinhiro
authors.initials: S
authors.lastname: Takeda
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Taniai
authors.forename: Keiji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Oda
authors.forename: Akira
authors.initials: A
authors.lastname: Asada
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Sakamoto
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D016031:Liver Transplantation; D019520:Living Donors; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000188:drug therapy*; D011595:Psychomotor Agitation / Q000188:drug therapy; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000316:Adrenergic alpha-Agonists; D020927:Dexmedetomidine