title: Perirhinal cortex lesions impair simultaneous but not serial feature-positive discrimination learning.
abstract: The role of the perirhinal cortex in discriminative eyeblink conditioning was examined by means of feature-positive discrimination procedures with simultaneous (A-/XA+) and serial (A-/X-->A+) stimulus compounds. Lesions of the perirhinal cortex severely impaired acquisition of simultaneous feature-positive discrimination but produced no impairment in serial feature-positive discrimination. The results suggest that the perirhinal cortex plays a role in discriminative eyeblink conditioning by resolving ambiguity in discriminations with overlapping stimulus elements.
authors.affiliation: Department of Psychology, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Campolattaro
authors.forename: John H
authors.initials: JH
authors.lastname: Freeman
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications; D003213:Conditioning, Psychological / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology*; D018728:Entorhinal Cortex / Q000473:pathology / Q000503:physiopathology*; D007859:Learning Disabilities / Q000209:etiology / Q000473:pathology*; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D012691:Serial Learning / Q000502:physiology*