title: Naphthopyrone glucosides from the seeds of Cassia tora with inhibitory activity on advanced glycation end products (AGEs) formation.
abstract: Three naphthopyrone glucosides, cassiaside (1), rubrofusarin-6-O-beta-D-gentiobioside (2), and toralactone-9-O-beta-D-gentiobioside (3), were isolated from the BuOH-soluble extract of the seeds of Cassia tora as active constituents, using an in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structures of 1-3 were determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates (1-3) were evaluated for the inhibitory activity on AGEs formation in vitro.
authors.affiliation: Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.
authors.forename: Ga Young
authors.initials: GY
authors.lastname: Lee
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Jang
authors.forename: Yun Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Kim
mesh_terms: D002366:Cassia / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017127:Glycation End Products, Advanced / Q000096:biosynthesis; D006031:Glycosylation; D015394:Molecular Structure; D011499:Protein Processing, Post-Translational; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism
chemical_list: D002867:Chromones; D004187:Disaccharides; D005960:Glucosides; D017127:Glycation End Products, Advanced; D011753:Pyrones; C119595:rubrofusarin gentiobioside; C513232:toralactone-9-O-gentiobioside; C119594:cassiaside; D012710:Serum Albumin, Bovine