Effect of Satureja khuzestanica essential oil on male rat fertility.
This study was undertaken to study the effect of Satureja khuzestanica essential oil (SKEO) in male rat fertility. SKEO was administered orally at doses of 75, 150, and 225 mg/kg/day for 45 days through drinking water. Treated and control rats were mated with female on day 45 of treatment. SKEO significantly improved all the parameters evaluated such as potency, fecundity, fertility index, and litter size. Moreover, concentrations of FSH and testosterone were significantly increased in SKEO-treated groups. Also the weights of testes, seminal vesicles, and ventral prostate weights were increased by SKEO (225 mg/kg). Histopathological analysis showed that in male rats treated with SKEO (150, 225 mg/kg) the number of spermatogonium, spermatid cords, Leydig cells, and spermatozoids was increased. Also in these groups, the Sertoli cells were hypertrophic.
Haeri
Sulmaz
S
Laboratory of Toxicology, Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Iran.
Minaie
Bagher
B
Amin
Gholamreza
G
Nikfar
Shekoufeh
S
Khorasani
Reza
R
Esmaily
Hadi
H
Salehnia
Alinazar
A
Abdollahi
Mohammad
M
D000284:Administration, Oral; D000818:Animals; D005260:Female; D005299:Fertility Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007248:Infertility, Male / Q000188:drug therapy; D008297:Male; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011467:Prostate / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D031362:Satureja; D012669:Seminal Vesicles / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D005299:Fertility Agents; D010938:Plant Oils; D013739:Testosterone