title: [Delayed graft function: a frequent but still unsolved problem in renal transplantation].
abstract: Delayed graft function (DGF) is a frequent and well-known complication of renal transplantation, which occurs in 30% of cadaver kidney allografts. It has an economic cost that is the result of prolonged patient hospitalization and the need for hemodialysis sessions; it also increases the risk of acute allograft rejection and may affect long-term graft survival. Lots of risk factors were identified, like donor hemodynamic compromise or prolonged cold ischemia time; however, incidence of DGF remains high due to the frequent use of marginal donors due to organ shortage. Recent advances in the pathophysiology of DGF point the importance of the ischemia-reperfusion injury mechanisms and some therapeutics that may reduce them are under investigation, like the use of new solutions to improve organ preservation and the use of some antioxidant and anti-inflammatory drugs.
authors.affiliation: Service de néphrologie, transplantation et dialyse péritonéale, hôpital Lapeyronie, CHU de Montpellier, France.
authors.forename: Ilan
authors.initials: I
authors.lastname: Szwarc
authors.forename: Valérie
authors.initials: V
authors.lastname: Garrigue
authors.forename: Sylvie
authors.initials: S
authors.lastname: Delmas
authors.forename: Sébastien
authors.initials: S
authors.lastname: Deleuze
authors.forename: Guillaume
authors.initials: G
authors.lastname: Chong
authors.forename: Georges
authors.initials: G
authors.lastname: Mourad
mesh_terms: D002102:Cadaver; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000502:physiology*; D011183:Postoperative Complications / Q000453:epidemiology; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors; D014019:Tissue Donors