title: Oral misoprostol administration for labor induction.
abstract: Using oral agents for induction of labor would reduce the need for repeated vaginal examinations; this is more acceptable to women and could reduce infection rates. A systematic review was conducted of 41 randomized trials comparing oral misoprostol to other induction agents. Oral misoprostol is effective at achieving vaginal delivery, and may have benefits over both vaginal and intracervical dinoprostone. Although it does not achieve vaginal delivery as quickly as vaginal misoprostol, the rates of hyperstimulation are lower when using comparable doses. As the primary consideration should be safety rather than speed, an oral regimen using a maximum of 50 mcg 4 hourly is recommended.
authors.affiliation: School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool Women's Hospital, Liverpool, UK. aweeks@liv.ac.uk
authors.forename: Andrew
authors.initials: A
authors.lastname: Weeks
authors.forename: Zarko
authors.initials: Z
authors.lastname: Alfirevic
mesh_terms: D000284:Administration, Oral; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010120:Oxytocics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011247:Pregnancy
chemical_list: D010120:Oxytocics; D016595:Misoprostol