Lateral membrane waves constitute a universal dynamic pattern of motile cells.
We have monitored active movements of the cell circumference on specifically coated substrates for a variety of cells including mouse embryonic fibroblasts and T cells, as well as wing disk cells from fruit flies. Despite having different functions and being from multiple phyla, these cell types share a common spatiotemporal pattern in their normal membrane velocity; we show that protrusion and retraction events are organized in lateral waves along the cell membrane. These wave patterns indicate both spatial and temporal long-range periodic correlations of the actomyosin gel.
Döbereiner
Hans-Günther
HG
Department of Biological Sciences, Columbia University, New York, New York 10027, USA. hgd@biophysik.uni-bremen.de
Dubin-Thaler
Benjamin J
BJ
Hofman
Jake M
JM
Xenias
Harry S
HS
Sims
Tasha N
TN
Giannone
Grégory
G
Dustin
Michael L
ML
Wiggins
Chris H
CH
Sheetz
Michael P
MP
D000205:Actomyosin / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D005782:Gels / Q000737:chemistry; D051379:Mice; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology / Q000502:physiology*; D013997:Time Factors
D005782:Gels; D000205:Actomyosin