title: [Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes].
abstract: OBJECTIVE
  To analyze the susceptibility genes of a Parkinson's Disease (PD) family.
  
  
  METHODS
  The blood samples of a four-generation classic idiopathic PD family were collected. Two-point LOD score method was applied to analyze the linkage disequilibrium between the disease locus and microsatellite markers.
  
  
  RESULTS
  We studied 13 markers near the 9 genes that had been reported to be associated with PD. No obvious evidence showed that the selected markers had anything correlation with PD locus.
  
  
  CONCLUSIONS
  These 9 genes are not the susceptibility genes of PD in this family.
authors.affiliation: Department of Medical Genetics, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Shu
authors.forename: You-Yong
authors.initials: YY
authors.lastname: Tian
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Jian-Kun
authors.initials: JK
authors.lastname: Yu
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Qian
authors.forename: Jia-You
authors.initials: JY
authors.lastname: Chu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D010375:Pedigree