[The role of oxidative metabolism in pathogenesis of hyperbilirubinemia in infants].
The aim of the study was the investigation of free radical oxidation intensity in blood of newborn infants with hyperbilirubinemia. In infants blood the bilirubin, free nitric oxide, lipoperoxide radicals Fe(2+)-ions, methemoglobin, oxy- and desoxy hemoglobin content, erythrocytes deformability and resistance were studied. Results of the study testify the intensive generation of free nitric oxide, release of ferritin-free ferrous (Fe(2+)), intensification of lipoperoxidation, decrease of red blood cells resistance, and accumulation of methemoglobin in blood of newborn infants with hyperbilirubinemia. The low content of nitric oxide in blood is due to its oxidative transformation to peroxynitrite. NOO(-)-inducible hemolysis of erythrocytes is one of promoters of hyperbilirubinemia in infants. It was concluded, that the reason of infants hyperbilirubinemia is intensification of oxidative stress, formation of excessive nitric oxide, enhancing of red blood cells haemolysis and it promotes disturbance of erythrocytes membrane, decrease of their resistance and deformability, intensification of haemolysis and extrication of redox-active iron.
Abzhandadze
T Iu
TIu
Kvezereli-Kopadze
A N
AN
Dzhaparidze
E Sh
ESh
Tkhilava
N G
NG
Sanikidze
T V
TV
D004912:Erythrocytes / Q000378:metabolism; D016166:Free Radical Scavengers / Q000097:blood; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood*; D007231:Infant, Newborn; D008706:Methemoglobin / Q000378:metabolism; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D011379:Prognosis
D016166:Free Radical Scavengers; D009569:Nitric Oxide; D008706:Methemoglobin