title: Noisy silencing of chromatin.
abstract: Chromatin-based repression is a major mechanism for epigenetically heritable variation. Work in the July 21 issue of Molecular Cell quantitatively examines transcriptional silencing in individual yeast cells, demonstrating locus-specific effects and finding that different silencing mutants exhibit qualitatively distinct single-cell defects.
authors.affiliation: Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138.
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Rando
authors.forename: Johan
authors.initials: J
authors.lastname: Paulsson
mesh_terms: D002843:Chromatin / Q000235:genetics*; D020868:Gene Silencing; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin