title: [Iris mammillations: three case reports].
abstract: BACKGROUND
  Iris mammillations are congenital abnormalities characterized by vitiliform protuberances regularly spaced on the surface of a velvety iris. They can be either isolated or associated with melanocytosis involving iris, sclera or periocular tissues, resulting in a risk for uveal melanoma. They can be complicated by ocular hypertension. We report three cases of iris mammillations in three children.
  
  
  METHODS
  For each patient, age, circumstances of revelation, anterior and posterior segment examination, intraocular pressure, associated anomalies, and progression were noted. Patient no. 1: In a 13-month-old boy examined for a squint, bilateral iris mammillations were fortuitously discovered. Intraocular pressure remained normal over 22 months of follow-up. Patient no. 2: In an eight-year-old boy, bilateral iris mammillations with papillary excavation were fortuitously discovered. Intraocular pressure was normal and the excavation did not change over 20 months of follow-up. Patient no. 3: A five-year-old boy was examined for a scleral pigmentation in the right eye. The examination found unilateral iris mammillations and ipsilateral ocular melanocytosis. Intraocular pressure and fundus were normal and remained normal over 13 months of follow-up.
  
  
  CONCLUSIONS
  and conclusion: Iris mammillations are congenital abnormalities, generally unilateral, sometimes hereditary. The differential diagnosis includes Lisch nodules of neurofibromatosis and iris melanoma. The etiology of iris mammillations is unknown; these lesions can be complicated by ocular hypertony and, in case of associated melanocytosis of the iris, sclera or periocular tissues, by uveal melanoma. These potential complications warrant a regular clinical follow-up.
authors.affiliation: Service d'Ophtalmo-Pédiatrie, Fondation Ophtalmologique Adolphe de Rothschild, 25-29 rue Manin, 75940 Paris cedex 19.
authors.forename: W
authors.initials: W
authors.lastname: Kharrat
authors.forename: P
authors.initials: P
authors.lastname: Dureau
authors.forename: C
authors.initials: C
authors.lastname: Edelson
authors.forename: G
authors.initials: G
authors.lastname: Caputo
mesh_terms: D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007499:Iris Diseases / Q000473:pathology*; D008297:Male; D008548:Melanosis / Q000473:pathology; D012189:Retrospective Studies