title: Specificity by design.
authors.affiliation: Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, WAB 536, Boston, MA 02115, USA. pabo@hms.harvard.edu
authors.forename: Carl O
authors.initials: CO
authors.lastname: Pabo
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D001665:Binding Sites; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D004720:Endonucleases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D007438:Introns / Q000235:genetics; D008956:Models, Chemical; D008958:Models, Molecular; D009010:Monte Carlo Method; D011487:Protein Conformation; D015202:Protein Engineering / Q000379:methods; D013379:Substrate Specificity; D013816:Thermodynamics
chemical_list: D004247:DNA; D004720:Endonucleases