title: [Skin neuroendocrine carcinoma metastasis: a case report].
abstract: BACKGROUND
  Merkel cell carcinoma (MCC) is a rare and aggressive skin tumour with a highly malignant nature whose appropriate treatment is still debated. The Authors report a case of cutaneous metastasis from neuroendocrine carcinoma and analyse new diagnostic and therapeutic options of neoplasms that occurs in sun-exposed areas.
  
  
  METHODS
  The authors present the clinical, immunocytochemical characteristic of primary and secondary skin localization of a neuroendocrine tumor that affected a woman.
  
  
  RESULTS
  Histological and immunocytochemical analysis demonstrated that the secondary cutaneous localization appeared to be compared to the primary tumour.
  
  
  CONCLUSIONS
  The case confirm the high incidence of regional metastasis; a wide surgical excision of tumor and regional lymphadenectomy is therefore recommended for primary treatment of MCC; the radiation treatment minimized the local recidives with long time survival.
authors.affiliation: Dipartimento di Patologia Umana, Universit, degli Studi di Messina, Azienda Ospedaliera Universitaria, Policlinico G. Martino, Messina. rossitt@unime.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Rossitto
authors.forename: Francesco
authors.initials: F
authors.lastname: Fedele
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Pantè
authors.forename: Fabio
authors.initials: F
authors.lastname: Crescenti
authors.forename: Salvatore
authors.initials: S
authors.lastname: Incardona
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciccolo
authors.forename: Ciro
authors.initials: C
authors.lastname: Famulari
mesh_terms: D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D011859:Radiography; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D014463:Ultrasonography