Reproducibility of contrast enhanced magnetic resonance renography in adolescents.
OBJECTIVE
We sought to determine the reproducibility of magnetic resonance imaging renography using 3 different mathematical models and 2 different approaches to convert the relative signal intensity into quantitative indices. Furthermore, we wanted to examine the influence of fluid intake on the obtained renal parameters.


METHODS
A total of 10 healthy volunteers 13 to 16 years old were subjected to magnetic resonance imaging 3 times within 10 weeks, including an examination where fluid intake was increased. At each examination 0.1 mmol/kg gadolinium diethylenetriamine pentaacetic acid was administrated intravenously as a rapid bolus during a fast magnetic resonance renography sequence. Images were acquired in the coronal plan, and 1,200 images were recorded during approximately 7 minutes. Cortical data were analyzed to estimate absolute and differential function of renal parameters by converting signal intensities into quantitative units.


RESULTS
Using the simple approach that a change in magnetic resonance imaging signal is linearly related to the change in gadolinium diethylenetriamine pentaacetic acid concentration, we found reproducibility in the range of 1% to 5% of all estimations of the differential renal function. The relative glomerular ultrafiltration (ml per minute per cm(3) kidney cortex) was calculated and a reproducibility of 7% was observed for relative glomerular ultrafiltration (using the model based on deconvolution). Increased hydration caused a significant change in most parameters.


CONCLUSIONS
Contrast enhanced magnetic resonance renography is reproducible in the normal human kidney but excessive water intake has a significant influence on these parameters. Further studies are required to elucidate whether similar measurements can be applied to a kidney with impaired function.
Jørgensen
Bettina
B
Institute of Clinical Medicine, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardsvej, 8200 Aarhus, Denmark. bettina.jorgensen@ki.au.dk
Keller
Anna Krarup
AK
Radvanska
Eva
E
Rittig
Søren
S
Taagehøj-Jensen
Finn
F
Frøkiaer
Jørgen
J
Jørgensen
Troels Munch
TM
Pedersen
Michael
M
D000293:Adolescent; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011866:Radioisotope Renography / Q000379:methods*; D015203:Reproducibility of Results
D003287:Contrast Media