title: [Clinical observation on treatment of active systemic lupus erythematosus with haoqin qingdan decoction].
abstract: OBJECTIVE
  To observe the therapeutic efficacy and safety of Haoqin Qingdan Decoction (HQD) in treating active stage of systemic lupus erythematosus (SLE).
  
  
  METHODS
  One hundred and twenty patients with SLE were randomly assigned into two groups, the treated group receiving HQD and prednisone, and the control group receiving prednisone and cyclophosphamide (CTX), both were treated for 3 months. SLE disease activity index (SLEDAI), various immunological indexes, blood and urine routine, hepatic and renal function, as well as the other adverse reaction of the treatment were observed.
  
  
  RESULTS
  The total effective rate in the treated group was 81.67% (49/60), while 76.67% (46/60) in the control group, showing insignificant difference between the two groups. SLEDAI, erythrocyte sedimentation rate (ESR), complement 3 (C3), 24-hr urinary protein excretion and anti-double strain deoxyribonucleic acid (dsDNA) antibody were improved in the treated group, and no obvious adverse reaction was shown.
  
  
  CONCLUSIONS
  HQD is obviously more effective in treating active stage of SLE with high safety.
authors.affiliation: The First Affiliated Hospital of Tianjin College of TCM, Tianjin. fengshiliuwei@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003176:Complement C3 / Q000378:metabolism; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011241:Prednisone / Q000008:administration & dosage*
chemical_list: D003176:Complement C3; D004365:Drugs, Chinese Herbal; D011241:Prednisone