title: The imaging features of gastrointestinal stromal tumours.
abstract: Gastrointestinal stromal tumours (GISTs) are a rare group of mesenchymal neoplasms that occur predominantly in the gastrointestinal tract. Previously GISTs were classified as smooth muscle tumours referred to as leiomyomas, leiomyosacromas or leiomyoblastomas. However, with the advent of immunohistochemistry, GISTs are now defined by the identification of cKit positivity. This is now used to select patients with metastatic disease who may respond to chemotherapeutic agents such as the tyrosine kinase inhibitor, STI-571. In this pictorial essay we have attemped to describe the range of imaging findings of GISTs that can suggest a pre-biopsy diagnosis.
authors.affiliation: Department of Medical Imaging, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada. sullypos@yahoo.com <sullypos@yahoo.com>
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Sullivan
authors.forename: A C
authors.initials: AC
authors.lastname: Harris
authors.forename: S G
authors.initials: SG
authors.lastname: Ho
authors.forename: P L
authors.initials: PL
authors.lastname: Munk
mesh_terms: D003287:Contrast Media; D003952:Diagnostic Imaging; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans
chemical_list: D003287:Contrast Media