title: New efficient organic activators for highly enantioselective reduction of aromatic ketones by trichlorosilane.
abstract: [reaction: see text] Aryl ketones were reduced to the corresponding alcohols with excellent enantioselectivity (up to 99.7% ee) by Cl3SiH in the presence of a catalytic amount of N-formyl-alpha'-(2,4,6-triethylphenyl)-L-proline as an activator. Both carboxyl group at the alpha-position of the activator and 2,4,6-triethylphenyl group at the alpha'-position were critical for the high enantioselectivity.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University,Bunkyo-machi, Nagasaki 852-8521, Japan. matumura@net.nagasaki-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Kanako
authors.initials: K
authors.lastname: Ogura
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Kouchi
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Iwasaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Onomura