14Beta-hydroxy-10-deacetylbaccatin III as a convenient, alternative substrate for the improved synthesis of methoxylated second-generation taxanes.
This article describes a new, convenient, improved synthesis of the 2-debenzoyl-2-m-methoxybenzoyl-7-triethylsilyl-13-oxo-14beta-hydroxybaccatin III 1,14-carbonate, the key intermediate in the synthesis of two new second-generation antitumor taxanes.
Barboni
Luciano
L
Dipartimento di Scienze Chimiche, Università di Camerino, Via S. Agostino 1, 62032 Camerino (MC), Italy. luciano.barboni@unicam.it
Giarlo
Guido
G
Ballini
Roberto
R
Fontana
Gabriele
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D043823:Taxoids / Q000138:chemical synthesis* / Q000737:chemistry; D014297:Trimethylsilyl Compounds
C515124:14-hydroxy-10-deacetylbaccatin III; C515125:2-debenzoyl-2-m-methoxybenozyl-7-triethylsilyl-13-oxo-14-hydroxybaccatin III 1,14-carbonate; D000970:Antineoplastic Agents; D017646:Organosilicon Compounds; D043823:Taxoids; D014297:Trimethylsilyl Compounds