Osteonecrosis after allogeneic stem cell transplantation in childhood. A case-control study in Italy.
A case-control study was conducted among Italian children treated with a stem cell transplant (SCT). Cases (n = 43) were allogeneic recipients with osteonecrosis, and the controls (n = 129) were matched to the corresponding cases on the basis of survival, SCT center and date of transplant. Univariate analysis showed that older age at SCT (OR 1.39; 95% CI 1.24-1.57), total body irradiation (TBI) (OR 5.73; 95% CI 2.38-13.83), chronic graft-versus-host disease (GvHD) (OR 4.31; 95% CI 2.05-9.07), and duration of steroid treatment after SCT (OR 1.118; 95% CI 1.034-1.209) were statistically correlated with osteonecrosis. However, multivariate analysis revealed that the only factors that were significantly associated with osteonecrosis were older age at SCT (p = 0.0001), TBI (p = 0.001) and chronicGvHD (p = 0.001).
Faraci
Maura
M
Dept. of Hematology/Oncology, Bone Marrow Transplantation Section, G. Gaslini Children's Hospital, Largo G. Gaslini, 5, 16147 Genova, Italy. maurafaraci@ospedale-gaslini.ge.it
Calevo
Maria Grazia
MG
Lanino
Edoardo
E
Caruso
Silvia
S
Messina
Chiara
C
Favr
Claudio
C
Iori
Anna
A
Santaron
Stella
S
Bonanomi
Sonia
S
Rondelli
Roberto
R
Dini
Giorgio
G
Haupt
Riccardo
R
D000704:Analysis of Variance; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D007558:Italy; D010020:Osteonecrosis / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D012042:Registries; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D016019:Survival Analysis; D014184:Transplantation, Homologous / Q000009:adverse effects; D014916:Whole-Body Irradiation