[Changes in activity of the hypothalamic neurons in response to physiological fluctuations of the homeostasis constants].
In acute experiments on cats under the combined narcosis (ketamine + N2O) we have investigated impulse activity of the rostral hypothalamic neurons and analyzed its modifications due to visceral stimulation. As stimulation we used warmed up or cooled (on 7 degrees C) a paw of an animals, cooled a body of an animal, we administered solutions into a carotid artery: 5 % of glucose, 0,2 % and 3 % NaCl, phenilephrine. Thus we modeled fluctuation of homeostasis's constants in physiological limits in an animal organism. It is shown that the greatest quantity of investigated neurons--more than 10 % authentically changes a pattern impulse activity when we entered solutions of 5 % of glucose and 0,2 % NaCl into a carotid artery of animals. In other cases the degree of transformation of a pattern was less (6-7 %) and approximately identical. When we entered of a microdose phenilephrine into the v. femoralis in order to modulate press effect we registered minimal quantity of neurons (1,4%). Studing of the parameters of the IA hypothalamic neurons during the homeostatic changes could be a basis for finding of transformation of the functional state of neurons which take part in the regulator mechanisms for maintaining of homeostasis.
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D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002415:Cats; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010656:Phenylephrine / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013696:Temperature
D010656:Phenylephrine; D012965:Sodium Chloride; D005947:Glucose