title: Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study.
abstract: The aim of this study was to estimate the heritability and describe the correlates of bone marrow lesions in knee subchondral bone. A sibpair design was used. T2- and T1-weighted MRI scans were performed on the right knee to assess bone marrow lesions at lateral tibia and femora and medial tibia and femora, as well as chondral defects. A radiograph was taken on the same knee and scored for individual features of osteoarthritis (radiographic osteoarthritis; ROA) and alignment. Other variables measured included height, weight, knee pain, and lower-limb muscle strength. Heritability was estimated with the program SOLAR (Sequential Oligogenetic Linkage Analysis Routines). A total of 115 siblings (60 females and 55 males) from 48 families, representing 95 sib pairs, took part. The adjusted heritability estimates were 53 +/- 28% (mean +/- SEM; p = 0.03) and 65 +/- 32% (p = 0.03) for severity of bone marrow lesions at lateral and medial compartments, respectively. The estimates were reduced by 8 to 9% after adjustment for chondral defects and ROA (but not alignment). The adjusted heritability estimate was 99% for prevalent bone marrow lesions at both lateral and medial compartments. Both lateral and medial bone marrow lesions were significantly correlated with age, chondral defects, and ROA of the knee (all p < 0.05). Medial bone marrow lesions were also more common in males and were correlated with body mass index (BMI). Thus, bone marrow lesions have a significant genetic component. They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI.
authors.affiliation: Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia.
authors.forename: Guangju
authors.initials: G
authors.lastname: Zhai
authors.forename: James
authors.initials: J
authors.lastname: Stankovich
authors.forename: Flavia
authors.initials: F
authors.lastname: Cicuttini
authors.forename: Changhai
authors.initials: C
authors.lastname: Ding
authors.forename: Graeme
authors.initials: G
authors.lastname: Jones
mesh_terms: D000328:Adult; D017677:Age Distribution; D000886:Anthropometry; D001175:Arthrography; D015992:Body Mass Index; D001855:Bone Marrow Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D004777:Environment; D005260:Female; D005269:Femur / Q000473:pathology; D006801:Humans; D015994:Incidence; D007719:Knee Joint / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging; D012720:Severity of Illness Index; D017678:Sex Distribution; D035781:Siblings; D013977:Tibia / Q000473:pathology