Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy.
Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5'-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n=32) and carbamazepine (group B, n=20) monotherapy. P-tHcy significantly increased in both groups, s-F and s-B12 significantly increased in group A, while s-F and p-PLP significantly decreased in group B. Our study showed an early effect of antiepileptic drug treatment on homocysteine metabolism.
Attilakos
Achilleas
A
Second Department of Pediatrics, University of Athens, Panagiotis and Aglaia Kyriakou Children's Hospital, 1 Dimitsanis Street, Marousi, 15125 Athens, Greece. attilakos@hotmail.com
Papakonstantinou
Evangellos
E
Schulpis
Kleopatra
K
Voudris
Konstantinos
K
Katsarou
Eustathia
E
Mastroyianni
Sotiria
S
Garoufi
Anastasia
A
D000293:Adolescent; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D002220:Carbamazepine / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000378:metabolism*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011732:Pyridoxal Phosphate / Q000097:blood; D014635:Valproic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D014805:Vitamin B 12 / Q000097:blood
D000927:Anticonvulsants; D006710:Homocysteine; D002220:Carbamazepine; D011732:Pyridoxal Phosphate; D014635:Valproic Acid; D005492:Folic Acid; D014805:Vitamin B 12