[Cytoadherence in cerebral malaria as particular example of pathology in host--parasite system].
Cerebral malaria in man and in animals is the consequence of a cascade of events, involving the patological changes, leading to the amplification of the expression of the receptors for cytoadherence on brain capillary endothelial cells. Sequestration is the process by which erytrocytes infected with the mature forms of the malaria parasite Plasmodium falciparum disappear from circulation and accumulate within venules and capillaries of various organs and tissues. The molecular mechanism in sequestration is one of the most rapidly advancing fields in malaria research. The several specific aspects considered in this paper. Our electron micrographs show cytoadherence in own model of cerebral malaria in rats infected with Plasmodium berghei.
Stelmach
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WR
Wojskowa Akademia Medyczna Zakład Medycyny Tropikalnej w Gdyni Gdynia ul. Grudzińskiego 4.
Walski
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Olszański
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D000818:Animals; D001921:Brain / Q000098:blood supply; D002196:Capillaries; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000648:ultrastructure*; D004912:Erythrocytes / Q000473:pathology* / Q000648:ultrastructure; D006790:Host-Parasite Interactions; D016779:Malaria, Cerebral / Q000469:parasitology* / Q000473:pathology*; D051379:Mice; D010962:Plasmodium berghei; D051381:Rats; D016024:Receptors, Cytoadhesin / Q000648:ultrastructure
D015815:Cell Adhesion Molecules; D016024:Receptors, Cytoadhesin