Nonabsorbable dietary fat enhances disposal of 2,2',4,4'-tetrabromodiphenyl ether in rats through interruption of enterohepatic circulation.
Polybrominated diphenyl ethers are lipophilic persistent organic pollutants (POPs), which accumulate in the environment, leading to human exposure. The compounds exert a negative impact on human health. Strategies to prevent or diminish their accumulation in humans are required. We investigated in rats whether the disposal rate of 14C-labeled tetrabromodiphenyl ether (BDE-47) could be enhanced by increasing fecal fat excretion through dietary treatment with nonabsorbable fat (sucrose polyester, SPE). As compared to control rats, SPE treatment increased fecal excretion rates of fat (+188%, p < 0.05) and 14C-BDE-47 (+291%, p < 0.05). On the basis of biliary secretion and fecal excretion rates of 14C-BDE-47, SPE effectively inhibited the enterohepatic circulation of 14C-BDE-47. In conclusion, dietary supplementation of nonabsorbable fat can enhance excretion of hydrophobic POPs by interruption of their enterohepatic circulation. Our data indicate that this strategy could decrease concentrations of hydrophobic POPs in the human body and thereby their impact on human health.
Meijer
Lisethe
L
Department of Pediatrics, Beatrix Children's Hospital, 9700 RB Groningen, The Netherlands. Lisethe.meijer@gmail.com
Hafkamp
Anja M
AM
Bosman
Wouter E
WE
Havinga
Rick
R
Bergman
Ake
A
Sauer
Pieter J J
PJ
Verkade
Henkjan J
HJ
D000818:Animals; D002250:Carbon Radioisotopes; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004764:Enterohepatic Circulation / Q000187:drug effects*; D005243:Feces / Q000737:chemistry; D055768:Halogenated Diphenyl Ethers; D006842:Hydrocarbons, Brominated / Q000032:analysis / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D008297:Male; D010647:Phenyl Ethers / Q000032:analysis / Q000493:pharmacokinetics*; D011075:Polybrominated Biphenyls; D051381:Rats; D017208:Rats, Wistar
D002250:Carbon Radioisotopes; D004041:Dietary Fats; D055768:Halogenated Diphenyl Ethers; D006842:Hydrocarbons, Brominated; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; C511295:2,2',4,4'-tetrabromodiphenyl ether