CD24 V/V is an allele associated with the risk of developing multiple sclerosis in the Spanish population.
The allele C in the CD24 gene has been related to multiple sclerosis (MS). In this work we check this single nucleotide polymorphism (SNP) in a population of 135 patients and 285 controls. Our results confirm the association between the V/V genotype at aa 57 of this gene and MS and highlight the importance of taking into account the origin of the subjects to avoid a population bias.
Otaegui
D
D
Unidad Experimental, Hospital Donostia, San Sebastián, Spain. uniexpe2@chdo.osakidetza.net
Sáenz
A
A
Camaño
P
P
Blázquez
L
L
Goicoechea
M
M
Ruíz-Martínez
J
J
Olaskoaga
J
J
Emparanza
J A
JA
López de Munain
A
A
D000328:Adult; D051927:CD24 Antigen / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D044465:White People / Q000235:genetics
D051927:CD24 Antigen; C497889:CD24 protein, human