What is ZAP-70?
Zap-70, a crucial molecule for the selective activation of T cells, through its interaction with the zeta chain of the TCR/CD3 complex, is a tyrosine kinase. This well studied molecule has gained a renewed interest upon the demonstration of its transduction and expression in B cells from patients with chronic lymphocytic leukemia. Here the major characteristics of this cytosolic protein are reviewed, as well as its expression in various cell types and some indications about its detection.
Béné
Marie Christine
MC
Immunology Laboratory, Faculty of Medicine & CHU, Nancy, France. marie-christine.bene@medecine.uhp-nancy.fr
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000032:analysis / Q000235:genetics / Q000378:metabolism
D014408:Biomarkers, Tumor; D011948:Receptors, Antigen, T-Cell; D051746:ZAP-70 Protein-Tyrosine Kinase