title: Factors influencing outcome after intestinal transplantation in children.
abstract: We evaluated 131 patients (6 months-14 years) who experienced 21 deaths before listing, 11 continuing on the waiting list, 38 well on home parenteral nutrition, 6 off parenteral nutrition and 59 transplanted (20 girls) aged 2.5 to 15 years, (18 >7 years). They received cadaveric isolated intestine (ITx, n = 31) or liver-small bowel (LITx, n = 32), including right colon (n = 43; 23 LITx) for short bowel (n = 19), enteropathy (n = 20), Hirschsprung (n = 14), or pseudo-obstruction (n = 6). Treatment included tacrolimus, steroids, azathioprine, or interleukin-2 blockers. After 6 months to 10.5 years, the patient and graft survivals were 75% and 54%. Sixteen patients (10 LITx) died within 3 months from surgery (n = 3), bacterial (n = 5) or fungal (n = 6) sepsis, or posttransplant lymphoproliferative disorder (n = 2). Rejection occurred in 27 patients, including 10 steroid-resistant episodes requiring antilymphoglobulins. The grafts were removed due to uncontrolled rejection in seven ITx recipients. Surgical complications were observed in 38 recipients (25 LSBTx) within 2 months, including bacterial (n = 22) or fungal (n = 11) sepsis, cytomegalovirus disease (n=12), adenovirus (n = 11), or posttransplant lymphoproliferative disorder (n = 12). Forty-two children (19 LSBTx) are alive. Weaning from parenteral nutrition was achieved after 42 days (median). Factors related to death or graft loss were pre-Tx surgery (P < .01), pseudo-obstruction (P < .01), age over 7 years (P < .03), fungal sepsis (P < .03), steroid resistant rejection (P < .05), hospitalized versus home patient (P < .01), and retransplantation (P < .05). Colon transplant did not affect the outcome. Interleukin-2 blockers improved isolated ITx (P < .05). Early referral and close monitoring of intestinal failure and related disorders are mandatory to achieve successful ITx.
authors.affiliation: UFR Necker-Enfants Malades, University René Descartes Paris V, FAMA de Transplantation Intestinale, AP-HP, 149 Rue de Sèvres, 757015 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Sauvat
authors.forename: L
authors.initials: L
authors.lastname: Dupic
authors.forename: D
authors.initials: D
authors.lastname: Caldari
authors.forename: F
authors.initials: F
authors.lastname: Lesage
authors.forename: J P
authors.initials: JP
authors.lastname: Cezard
authors.forename: F
authors.initials: F
authors.lastname: Lacaille
authors.forename: F
authors.initials: F
authors.lastname: Ruemmele
authors.forename: J P
authors.initials: JP
authors.lastname: Hugot
authors.forename: V
authors.initials: V
authors.lastname: Colomb
authors.forename: D
authors.initials: D
authors.lastname: Jan
authors.forename: P
authors.initials: P
authors.lastname: Hubert
authors.forename: Y
authors.initials: Y
authors.lastname: Revillon
authors.forename: O
authors.initials: O
authors.lastname: Goulet
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000145:classification / Q000601:surgery; D007421:Intestine, Small / Q000637:transplantation*; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous / Q000401:mortality / Q000502:physiology; D017211:Treatment Failure; D016896:Treatment Outcome