The histone deacetylase inhibitor FK228 may have therapeutic usefulness to prevent suicidal behaviour via upregulation of the guanosine triphosphatase Rap-1.
Emanuele
Enzo
E
D047630:Depsipeptides / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D013406:Suicide, Attempted / Q000517:prevention & control*; D020827:rap1 GTP-Binding Proteins / Q000235:genetics*
D047630:Depsipeptides; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; C087123:romidepsin; D020827:rap1 GTP-Binding Proteins