Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis.
New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their structures were established by various spectroscopic analyses. Compounds 1 and 3 were proposed to be biosynthesized from the oxidative coupling of the precursor hispidin with 3,4-dihydroxybenzaldehyde and 3,4-dihydroxybenzoic acid, respectively. These compounds exhibited significant scavenging activity against the ABTS radical cation, and compounds 2 and 4 displayed moderate superoxide radical scavenging activity.
Lee
In-Kyoung
IK
Functional Metabolomics Research Center, KRIBB, Yuseong, Daejeon 305-333, Republic of Korea.
Jung
Jin-Young
JY
Seok
Soon-Ja
SJ
Kim
Wan-Gyu
WG
Yun
Bong-Sik
BS
D000363:Agaricales / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000378:metabolism*; D011753:Pyrones / Q000302:isolation & purification / Q000378:metabolism*
D016166:Free Radical Scavengers; D011753:Pyrones