The vasoactive intestinal peptide receptor turnover in pulmonary arteries indicates an important role for VIP in the rat lung circulation.
Vasoactive intestinal peptide (VIP) is a potent vasorelaxing peptide that plays a role in lung physiology and possibly in pulmonary hypertension. We investigated the turnover of the VIP receptors on rat pulmonary arteries ex vivo. There was evidence for a fast receptor turnover in pulmonary arteries, which underlines the important role of VIP for the regulation of pulmonary circulation and pulmonary pathology.
Petkov
Ventzislav
V
Medical University Vienna, KIM-1, Institute of Cancer Research, Borschkegasse 8a, A-1090 Wien, Austria.
Gentscheva
Temenuschka
T
Schamberger
Chantal
C
Haberl
Ines
I
Artl
Andreas
A
Andreae
Fritz
F
Mosgoeller
Wilhelm
W
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D008297:Male; D011651:Pulmonary Artery / Q000187:drug effects* / Q000378:metabolism*; D011652:Pulmonary Circulation / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018005:Receptors, Vasoactive Intestinal Peptide / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide; D000109:Acetylcholine