title: Essential tremor associated with pathologic changes in the cerebellum.
abstract: BACKGROUND
  Although essential tremor (ET) is one of the most common neurologic disorders, there have been few postmortem studies. We recently reported postmortem changes (torpedoes and Bergmann gliosis) in the cerebellar cortex in a few ET cases.
  
  
  OBJECTIVE
  To describe more extensive postmortem changes in the cerebellum in another ET case.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 90-year-old woman had a 30-year history of ET. At postmortem examination, there was segmental loss of Purkinje cells, presence of torpedoes, and Bergmann gliosis in the cerebellar cortex. Moreover, there were extensive changes in the dentate nucleus, in the form of neuronal loss, neuronal atrophy, microglial clusters, and reduction in the number of efferent fibers (ie, pallor of the hilum).
  
  
  CONCLUSIONS
  The brain in the current case exhibited more marked cerebellar pathologic features than noted in previously reported ET cases and thereby extends the described cerebellar findings in this common, yet pathologically poorly characterized, neurologic disorder.
authors.affiliation: Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 W. 168th Street, New York, NY 10032, USA. EDL2@columbia.edu
authors.forename: Elan D
authors.initials: ED
authors.lastname: Louis
authors.forename: Jean Paul G
authors.initials: JP
authors.lastname: Vonsattel
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Honig
authors.forename: Arlene
authors.initials: A
authors.lastname: Lawton
authors.forename: Carol
authors.initials: C
authors.lastname: Moskowitz
authors.forename: Blair
authors.initials: B
authors.lastname: Ford
authors.forename: Steven
authors.initials: S
authors.lastname: Frucht
mesh_terms: D000369:Aged, 80 and over; D002531:Cerebellum / Q000473:pathology*; D020329:Essential Tremor / Q000473:pathology*; D005260:Female; D006801:Humans