Antihyperglycemic effect of Cucurbita ficifolia fruit extract in streptozotocin-induced diabetic rats.
In the present study, the antihyperglycemic effects of Cucurbita ficifolia fruit extract were investigated on streptozotocin-induced experimental diabetes in rats. Oral administration of the extract (300 and 600 mg/kg body weight, day) for 30 days resulted in a significant reduction in blood glucose, glycosylated haemoglobin, and an increase in plasma insulin and total haemoglobin. The effect was compared with 150 mg/kg b.w. tolbutamide.
Xia
Tao
T
College of Life Science, East China Normal University, 3663 Zhongshang North Rd., Shanghai 200062, PR China. txia@bio.ecnu.edu.cn
Wang
Qin
Q
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D028464:Cucurbita; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D006442:Glycated Hemoglobin / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D013311:Streptozocin