title: Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
abstract: The synthesis and in vitro antitumour evaluation of a new series of fluorinated benzothiazole-substituted 4-hydroxycyclohexa-2,5-dienones ('quinols') is described. The new compounds were found to be of comparable activity compared to the non-fluorinated precursor PMX 464, in terms of antiproliferative activity in sensitive human cancer cell lines (nanomolar GI(50) values) and inhibitory activity against the thioredoxin signalling system.
authors.affiliation: Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: Cedric J
authors.initials: CJ
authors.lastname: Lion
authors.forename: Charles S
authors.initials: CS
authors.lastname: Matthews
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Wells
authors.forename: Tracey D
authors.initials: TD
authors.lastname: Bradshaw
authors.forename: Malcolm F G
authors.initials: MF
authors.lastname: Stevens
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Westwell
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship; D013879:Thioredoxins / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D006873:Hydroquinones; D013879:Thioredoxins