title: Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles.
abstract: We have recently described the preparation of stable, polymeric nanoparticles, composed of poly(ethylene glycol) and poloxamer 407 (Pluronic F127), prepared via inverse emulsion photopolymerization. In the present study we report on the performance of this novel colloidal system as a controlled delivery system for small hydrophobic drugs. Successful encapsulation of doxorubicin occurred through hydrophobic interactions, taking advantage of particle nanoarchitecture. Loadings of up to 8.7wt.% were achieved with a reproducible, fast, solvent evaporation procedure. In vitro drug release, monitored by fluorescence spectrometry and HPLC, revealed a minor burst (approximately 10% at 37 degrees C) and sustained, diffusional release for over 1 week; furthermore, drug encapsulation significantly delayed doxorubicin degradation kinetics.
authors.affiliation: Institute of Bioengineering, SV/IBI/LMRP, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 15, CH-1015 Lausanne, Switzerland.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Missirlis
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kawamura
authors.forename: Nicola
authors.initials: N
authors.lastname: Tirelli
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Hubbell
mesh_terms: D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D053758:Nanoparticles; D020442:Poloxamer / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000008:administration & dosage; D012995:Solubility
chemical_list: D020442:Poloxamer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D004317:Doxorubicin