title: No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population.
abstract: Several lines of evidence have suggested that the metabotropic glutamate receptor 3 (GRM3) gene is a candidate susceptibility gene for schizophrenia. To our knowledge, six studies have investigated the genetic association between GRM3 and schizophrenia, although the results have been quite controversial. In the present study, we investigated the association between the GRM3 gene and schizophrenia in 402 Japanese people by analyzing 10 single nucleotide polymorphisms (SNPs), including all SNPs that showed significant results in previous studies. We observed no significant difference in allelic frequencies or genotypic distributions of the 10 SNPs between the controls and patients. A permutation test showed no significant global differences in estimated haplotype frequencies between the controls and patients. Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Motomu
authors.initials: M
authors.lastname: Suga
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yamasue
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D015723:Gene Library; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics; D012559:Schizophrenia / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*
chemical_list: D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C102718:metabotropic glutamate receptor 3