title: [A case of partial response in liver metastatic lesion from gastric endocrine cell carcinoma treated with TS-1].
abstract: Endocrine cell carcinoma (ECC) of the stomach is a rare pathological type with a poor outcome. Standard chemotherapy has not yet been established. We experienced a case of partial response in the liver metastasis from the gastric ECC treated with TS-1. The patient was a 68-year-old female. An upper GI series and gastroendoscopy revealed pyrolus stenosis and CT-scan showed liver metastasis. A non-curative total gastrectomy was performed to allow oral intake. Since the histopathological examination revealed that tumor cells were partially positive for chromogranin A on immunohistochemical study, we diagnosed tumor ECC of the stomach. The patient with liver metastasis was treated using TS-1, and CT-scan showed a remarkable decrease (PR) in the metastatic lesion. TS-1 administration can improve the clinical outcome for ECC of the stomach.
authors.affiliation: Dept. of Surgery, Kumamoto Rosai Hospital.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Hanada
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Inoue
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Osako
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kuriwaki
authors.forename: Shohei
authors.initials: S
authors.lastname: Shimajiri
authors.forename: Mizuho
authors.initials: M
authors.lastname: Mochinaga
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D010094:Oxonic Acid / Q000008:administration & dosage*; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid