title: [Assessment of elimination and tolerance of high dose of methotrexate (3 g/m2) in children with standard-risk acute lymphoblastic leukemia].
abstract: We assessed correlation between the elimination of methotrexate administered in dose 3 g/m2 during consolidation phase and the early complications in 129 children treated for acute lymphoblastic leukemia. Among 500 chemotherapy cycles included in the analysis the elimination of methotrexate was delayed in 66 (13.2%) cycles in 43 (33.3%) of patients. Influence of methotrexate on selected liver and renal function tests was analyzed. We made an attempt of early identification of patients with high risk for delayed methotrexate elimination and subsequent toxicities.
authors.affiliation: Klinika Onkologii i Hematologii Dzieciecej P-A Instytutu Pediatrii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Cwliklińska
authors.forename: Walentyna
authors.initials: W
authors.lastname: Balwierz
authors.forename: Jacek
authors.initials: J
authors.lastname: Nowak
authors.forename: Helena
authors.initials: H
authors.lastname: Stanuch
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006801:Humans; D007223:Infant; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008727:Methotrexate / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate