title: Etodolac-liquid-filled dispersion into hard gelatin capsules: an approach to improve dissolution and stability of etodolac formulation.
abstract: The formation of melt dispersion is an effective method of increasing the dissolution rate of poorly soluble drugs, and hence, of improving the bioavailability. The carrier fusion method was used to prepare different dispersion of etodolac using Gelucire 44/14 and D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS). The physical characteristics of the binary systems were determined by differential scanning calorimetry (DSC), infrared spectroscopy (IR). The release rate from the resulting dispersion was determined from dissolution studies by use of USP dissolution apparatus II (paddle method). The dissolution rate of etodolac is increased in all the dispersion systems compared to that of pure drug. A liquid dispersion system of etodolac (20%) and Gelucire 44/14: TPGS blend (80%), in different ratios, was also prepared. The capsule formulation was subjected to stability studies at different temperature and humidity conditions as per ICH guidelines. Physical and chemical properties of the dispersion didn't change during a period of storage at room temperature and at 4 degrees C, 0% RH. It was found that etodolac was chemically stable against the effects of temperature and humidity. However, the relative humidity and storage time exerted an effect on the dissolution behavior of etodolac. The changes in dissolution behavior after storage under conditions of high humidity and temperature might be related to the formation of etodolac microcrystal and to water absorption by the carrier during storage. It is predicted that acceptable shelf-lives should result when moisture-resistant packaging is used for pharmaceutical formulations of this type.
authors.affiliation: King Saud University, College of Pharmacy, Dept. of Pharmaceutics, Saudi Arabia. nsybarakat@yahoo.com
authors.forename: N S
authors.initials: NS
authors.lastname: Barakat
mesh_terms: D002152:Calorimetry, Differential Scanning; D002214:Capsules; D003460:Crystallization; D004337:Drug Carriers; D004355:Drug Stability; D017308:Etodolac / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D006813:Humidity; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D002214:Capsules; D004337:Drug Carriers; C104509:gelucire 44-14; D014810:Vitamin E; D017308:Etodolac; D011092:Polyethylene Glycols; D005780:Gelatin; C014225:tocophersolan