[Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes].
OBJECTIVE
To analyze the susceptibility genes of a Parkinson's Disease (PD) family.


METHODS
The blood samples of a four-generation classic idiopathic PD family were collected. Two-point LOD score method was applied to analyze the linkage disequilibrium between the disease locus and microsatellite markers.


RESULTS
We studied 13 markers near the 9 genes that had been reported to be associated with PD. No obvious evidence showed that the selected markers had anything correlation with PD locus.


CONCLUSIONS
These 9 genes are not the susceptibility genes of PD in this family.
Sun
Hao
H
Department of Medical Genetics, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China.
Zhang
Chang-Jun
CJ
Shu
Qing
Q
Tian
You-Yong
YY
Shi
Lei
L
Yu
Jian-Kun
JK
Qian
Ya-Ping
YP
Chu
Jia-You
JY
D000328:Adult; D000368:Aged; D002681:China; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D010375:Pedigree