title: Increased plasma levels of IL-6 in bacteremic periodontis patients after scaling.
abstract: Bacteremia frequently occurs after dental treatment. Periodontal inflammation may influence the incidence, magnitude and duration of bacteremia. The presence of circulating oral bacteria or bacterial components may induce cytokine synthesis in blood cells, which may contribute to the development or exacerbation of atherosclerosis. The present study tested the hypothesis that bacteremia occurring after scaling in periodontitis patients results in altered plasma levels of cytokines. Twenty periodontitis patients were subjected to scaling. Blood samples at baseline and at 0.5, 10 and 30 minutes postscaling were examined for bacteremia whereas baseline and eight-hour postscaling blood samples were examined for the levels of IL-1beta, TNF-alpha, IL-6, IL-8, IL-10 and IL-12p70. IL-6 levels were significantly increased eight hours after scaling, while IL-8 was significantly decreased. No systematic changes occurred in the levels of IL-1beta, TNF-alpha, IL-10 and IL-2p70. IL-6 levels may be increased while IL-8 may be decreased due to scaling, which may have implications for general health.
authors.affiliation: Noerre Allé 20, Copenhagen N 2200, Denmark. and@odont.ku.dk
authors.forename: Lone
authors.initials: L
authors.lastname: Forner
authors.forename: Claus Henrik
authors.initials: CH
authors.lastname: Nielsen
authors.forename: Klaus
authors.initials: K
authors.lastname: Bendtzen
authors.forename: Tove
authors.initials: T
authors.lastname: Larsen
authors.forename: Palle
authors.initials: P
authors.lastname: Holmstrup
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000276:immunology* / Q000382:microbiology; D016866:Bacteroidaceae Infections / Q000097:blood; D003774:Dental Plaque Index; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000145:classification; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D010518:Periodontitis / Q000097:blood*; D018720:Prevotella / Q000145:classification; D013290:Streptococcal Infections / Q000097:blood; D013291:Streptococcus / Q000145:classification; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12