title: A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers.
abstract: OBJECTIVE
  Ibuprofen arginate is a salt formulation of ibuprofen designed to reach target concentrations rapidly. The primary objective of this study was to compare the 12-h pharmacokinetic profile of S(+)-ibuprofen following administration of single doses of ibuprofen arginate (600 mg) and dexibuprofen (400 mg) in healthy volunteers.
  
  
  METHODS
  Twenty-four volunteers were recruited into an open-label, randomised, two-period, single-centre study with crossover design.
  
  
  RESULTS
  Both treatments were well tolerated. Ibuprofen arginate and dexibuprofen showed similar bioavailability for S(+)-ibuprofen. Compared with dexibuprofen, ibuprofen arginate demonstrated a 45% higher maximum concentration (C(max)), and a time to peak concentration (T(max)) 2 h sooner.
  
  
  CONCLUSIONS
  Ibuprofen arginate approaches maximum concentrations of S(+)-ibuprofen faster and higher than dexibuprofen.
authors.affiliation: Clinical Research Unit, Clínica Universitaria de Navarra, Universidad de Navarra, 31008, Pamplona, Spain. bsadaba@unav.es
authors.forename: Belén
authors.initials: B
authors.lastname: Sádaba
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Campanero
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Muñoz-Juarez
authors.forename: Isabel
authors.initials: I
authors.lastname: Gil-Aldea
authors.forename: Emilio
authors.initials: E
authors.lastname: García-Quetglas
authors.forename: Antonio
authors.initials: A
authors.lastname: Esteras
authors.forename: Jose R
authors.initials: JR
authors.lastname: Azanza
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001120:Arginine / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004844:Epistaxis / Q000139:chemically induced; D005260:Female; D006207:Half-Life; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007052:Ibuprofen / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D013237:Stereoisomerism; D013810:Therapeutic Equivalency; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D001120:Arginine; D007052:Ibuprofen; C106674:ibuprofen arginine