Neuroprotective effect of PACAP against kainic acid-induced neurotoxicity in rat retina.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion cells in the retina died after KA injection in the control group and PACAP treatment significantly promoted cell survival. These findings strongly suggest that PACAP plays very important roles in preventing cell death in the retina.
Seki
Tamotsu
T
Department of Ophthalmology, Kozawa Eye Hospital Eye Research Center, 2-2-11 Gokencho, Mito, Ibaraki 3100063, Japan. t.seki@kozawa-ganka.or.jp
Nakatani
Masayoshi
M
Taki
Chisato
C
Shinohara
Yuko
Y
Ozawa
Motoki
M
Nishimura
Shigeru
S
Ito
Hiroyuki
H
Shioda
Seiji
S
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D007608:Kainic Acid / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000187:drug effects*
D018696:Neuroprotective Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D007608:Kainic Acid