Empirical evaluation of the genetic similarity of samples from twin registries in Australia and the Netherlands using 359 STRP markers.
One way to achieve the large sample sizes required for genetic studies of complex traits is to combine samples collected by different groups. It is not often clear, however, whether this practice is reasonable from a genetic perspective. To assess the comparability of samples from the Australian and the Netherlands twin studies, we estimated Fst (the proportion of total genetic variability attributable to genetic differences between cohorts) based on 359 short tandem repeat polymorphisms in 1068 individuals. Fst was estimated to be 0.30% between the Australian and the Netherlands cohorts, a smaller value than between many European groups. We conclude that it is reasonable to combine the Australian and the Netherlands samples for joint genetic analyses.
Sullivan
Patrick F
PF
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, United States of America. pfsulliv@med.unc.edu
Montgomery
Grant W
GW
Hottenga
Jouke Jan
JJ
Wray
Naomi R
NR
Boomsma
Dorret I
DI
Martin
Nicholas G
NG
D001315:Australia; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009426:Netherlands; D011110:Polymorphism, Genetic; D012042:Registries; D018401:Sample Size; D020080:Tandem Repeat Sequences / Q000235:genetics*; D018433:Twin Studies as Topic; D014427:Twins / Q000235:genetics*