title: Unchanged rat brain amyloid precursor protein levels after exposure to benzodiazepines in vivo.
abstract: OBJECTIVE
  Recent studies emphasize a positive correlation between (cardiac) surgical interventions and increased risk for developing Alzheimer's disease in the late postoperative period. Since amyloid precursor protein and its neurotoxic derivatives play key roles in the development of Alzheimer's dementia, the impact of several agents used in the intra- and perioperative period is examined.
  
  
  METHODS
  Amyloid precursor protein concentrations were assessed by semi-quantitative Western-immunoblot in brains of rats following intraperitoneal treatment with diazepam and midazolam.
  
  
  RESULTS
  There were no significant changes in the amyloid precursor protein concentrations.
  
  
  CONCLUSIONS
  Both diazepam and midazolam are considered to be relatively safe with respect to amyloid precursor protein metabolism.
authors.affiliation: University of Szeged, Department of Psychiatry, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Kálmán
authors.forename: M
authors.initials: M
authors.lastname: Palotás
authors.forename: M
authors.initials: M
authors.lastname: Pákáski
authors.forename: M
authors.initials: M
authors.lastname: Hugyecz
authors.forename: Z
authors.initials: Z
authors.lastname: Janka
authors.forename: A
authors.initials: A
authors.lastname: Palotás
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000096:biosynthesis*; D000768:Anesthesia, General; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D001569:Benzodiazepines / Q000378:metabolism / Q000633:toxicity*; D001921:Brain / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D011184:Postoperative Period; D051381:Rats; D017207:Rats, Sprague-Dawley; D012306:Risk
chemical_list: D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal; D001569:Benzodiazepines; D003975:Diazepam; D008874:Midazolam