title: Biocompatibility of peritoneal dialysis fluid and influence of compositions on peritoneal fibrosis.
abstract: Conventional peritoneal dialysis fluid (PDF) is a bioincompatible solution because of several components. These unphysiological compositions might contribute to the development of peritoneal fibrosis. In the present overview we summarize the influence of each composition of PDF (acidic pH, high concentration of glucose and glucose degradation products; advanced glycation end-products and lactate) on the peritoneal fibrotic changes in long peritoneal dialysis (PD) patients. We also summarized the report of new approaches to the prevention of peritoneal fibrosis in Japan.
authors.affiliation: Division of Internal Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan. chiekogm@dnh.twmu.ac.jp
authors.forename: Chieko
authors.initials: C
authors.lastname: Higuchi
authors.forename: Hideki
authors.initials: H
authors.lastname: Nishimura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sanaka
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry; D015314:Dialysis Solutions / Q000009:adverse effects* / Q000737:chemistry; D005355:Fibrosis / Q000139:chemically induced; D005947:Glucose / Q000009:adverse effects; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007676:Kidney Failure, Chronic / Q000473:pathology* / Q000628:therapy*; D019344:Lactic Acid / Q000378:metabolism; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010537:Peritoneum / Q000473:pathology*
chemical_list: D001672:Biocompatible Materials; D015314:Dialysis Solutions; D017127:Glycation End Products, Advanced; D019344:Lactic Acid; D005947:Glucose