Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-).
Genetic manipulation of pituitary adenylate cyclase-activating polypeptide (PACAP) in mice has uncovered its involvement in psychomotor function. We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP (Adcyap1-/-) displayed intense jumping behavior when placed in a novel environment such as an open field. Here, we show that Adcyap1-/- mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild-type mice and that the selective serotonin (5-HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5-hydroxytryptophan, suppress jumping behavior. Our previous study showed a slight decrease in 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in Adcyap1-/- mouse brain. Taken together, these results suggest that there is a developmental aspect to the jumping behavior seen in Adcyap1-/- mice, and that jumping behaviour may involve the serotonergic system.
Shintani
Norihito
N
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Hashimoto
Hitoshi
H
Tanaka
Kazuhiro
K
Kawagishi
Naofumi
N
Kawaguchi
Chihiro
C
Hatanaka
Michiyoshi
M
Ago
Yukio
Y
Matsuda
Toshio
T
Baba
Akemichi
A
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000375:Aging / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D010805:Physical Conditioning, Animal; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology*
C495402:Adcyap1 protein, mouse; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D012702:Serotonin Antagonists; D005473:Fluoxetine; D012701:Serotonin; D006916:5-Hydroxytryptophan