title: [Reactivation of Epstein-Barr virus is involved in the pathogenesis of lymphomatoid granulomatosis].
abstract: Recent studies point to a role of Epstein-Barr virus in the pathogenesis of lymphomatoid granulomatosis. Little is however known about the association of the pathogenesis of the disease with Epstein-Barr virus reactivation. A 46-year-old man presented with fever and general malaise. He had been admitted with fever of unknown origin 10 years previously. Chest radiographs and CT scans showed multiple nodular shadows in both lung fields. PET/CT showed strong accumulation in lung nodules, femoral muscle, lumbar subcutaneous nodule. He died of rapidly progressive neurological lesions. The definitive diagnosis of lymphomatoid granulomatosis was made from histological findings of the surgical biopsy specimen and at autopsy. Elevation of early antigen-IgG titer in serum was shown in this case. This result suggests that reactivation of Epstein-Barr virus is involved in the development of the disease.
authors.affiliation: Department of Respiratory Medicine, Saiseikai Yamagata Saisei Hospital.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kishi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Machida
authors.forename: Sinichirou
authors.initials: S
authors.lastname: Mikura
authors.forename: Keitarou
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D004854:Herpesvirus 4, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000209:etiology* / Q000821:virology*; D008230:Lymphomatoid Granulomatosis / Q000209:etiology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014775:Virus Activation
chemical_list: D007074:Immunoglobulin G