Glycosylated foldamers to probe the carbohydrate-carbohydrate interaction.
The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate-carbohydrate interactions.
Simpson
Graham L
GL
School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
Gordon
Andrew H
AH
Lindsay
David M
DM
Promsawan
Netnepa
N
Crump
Matthew P
MP
Mulholland
Keith
K
Hayter
Barry R
BR
Gallagher
Timothy
T
D002241:Carbohydrates / Q000737:chemistry*; D006031:Glycosylation; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding
D002241:Carbohydrates; D010455:Peptides