title: Development of type 2 diabetes in children and adolescents.
abstract: Type 2 diabetes is emerging as a significant health problem in children and adolescents. The disease usually develops in obese insulin-resistant youth with a typical pattern of lipid partitioning characterized by increased lipid deposition in myocytes, the visceral compartment, and the liver. Unfavorable adipocytokine profiles, together with a state of low-grade inflammation, create an additional metabolic burden tightly coupled to other components of the metabolic syndrome. Insufficient beta-cell compensation promotes altered glucose metabolism.
authors.forename: Ram
authors.initials: R
authors.lastname: Weiss
authors.forename: Sara E
authors.initials: SE
authors.lastname: Taksali
authors.forename: Sonia
authors.initials: S
authors.lastname: Caprio
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050356:Lipid Metabolism / Q000502:physiology*; D009765:Obesity / Q000150:complications
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin