title: The research of molecular and ionic mechanisms in vagally mediated atrial fibrillation in canine.
abstract: BACKGROUND
  The reentrant mechanism of vagally mediated AF is not clearly elucidated.
  
  
  RESULTS
  After vagal stimulation, thirty dogs were divided AF group (AF could be induced) and control group (AF could not be induced). Western blot and patch clamp were used to determine M(2) receptor and I(K,ACh) in left atrial appendage (LAA), right atrial appendage (RAA), left atrium (LA), right atrium (RA), pulmonary veins (PVs) and superior vena cava (SVC). In control group, the densities of M(2) receptor and I(K,ACh) in LAA, RAA and LA were higher than that in RA, PVs and SVC. However, there was no significant difference in LAA, RAA and LA. In AF group, the densities of M(2) receptor and I(K,ACh) in LAA, RAA and LA were higher than that in RA, PVs and SVC. Furthermore, the densities of the M(2) and I(K,ACh) in LAA and RAA were higher than that in LA.
  
  
  CONCLUSIONS
  Atrial appendage perhaps play an important role in initiation of cholinergic AF. However, PVs and SVC less often play an important role in vagotonic paroxysmal AF.
authors.forename: Qing-Yan
authors.initials: QY
authors.lastname: Zhao
authors.forename: Cong-Xin
authors.initials: CX
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Jin-Jun
authors.initials: JJ
authors.lastname: Liang
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Geng-Shan
authors.initials: GS
authors.lastname: Li
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000209:etiology / Q000503:physiopathology*; D004285:Dogs; D004558:Electric Stimulation; D007477:Ions; D008967:Molecular Biology; D014630:Vagus Nerve
chemical_list: D007477:Ions