Evaluation of sympathetic re-innervation in heterotopic cardiac transplants by iodine-123-metaiodobenzylguanidine (I-123-MIBG) imaging.
Scintigraphy using iodine-123-metaiodobenzylguanidine (I-123-MIBG) has been used to demonstrate that >50% of orthotopically transplanted hearts undergo partial cardiac sympathetic re-innervation and that this occurs no earlier than 1 year post-transplant. This study used planar and singe-photon emission computed tomography (SPECT) I-123 MIBG scintigraphy to show that cardiac re-innervation was not detectable in any of the 8 patients studied 1.1 to 6.3 years post-heterotopic transplantation. Thus, potential for cardiac re-innervation varies according to the type of procedure performed.
Yap
Kenneth S K
KS
Department of Nuclear Medicine, The Alfred Hospital, Melbourne, Australia. kskyap@yahoo.com
Gould
Paul
P
Kalff
Victor
V
Kaye
David M
DM
Esmore
Don
D
Kelly
Michael J
MJ
D019797:3-Iodobenzylguanidine; D000328:Adult; D000368:Aged; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation*; D016027:Heart Transplantation; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging*
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine