title: [Relationship of hypoxia-induced factor with tumor angiogenesis in early liver metastasis in colonic cancer].
abstract: OBJECTIVE
  To study the relationships of hypoxia-induced factor (HIF) with tumor angiogenesis and early liver metastasis in colonic cancer.
  
  
  METHODS
  Thirty three cases of colon cancer undergoing radical surgery were divided into two groups according to liver metastasis or not within half a year after operation. Expressions of HIF and vascular endothelial growth factor (VEGF) were examined using immunohistochemical method and tumor microvessel density (MVD) was measured in colonic cancer specimens.
  
  
  RESULTS
  Fifteen cases developed early liver metastasis, while 18 did not. The positive rates of HIF and VEGF, and MVD were 86.7%, 66.7%, (57.9+/- 12.7)% respectively in the group with early liver metastasis, significantly higher than 44.4% (P< 0.05), 27.8% (P< 0.05) and (22.3+/- 10.2)% (P< 0.01) respectively in the group without early liver metastasis respectively.
  
  
  CONCLUSIONS
  HIF can promote tumor angiogenesis in colonic cancer, and is closely related with early liver metastasis.
authors.affiliation: Department of General Surgery, Shenzhen Second People's Hospital, Shenzhen 518035, China.
authors.forename: Hao-hui
authors.initials: HH
authors.lastname: Liang
authors.forename: Cheng-you
authors.initials: CY
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Shu-bang
authors.initials: SB
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D008113:Liver Neoplasms / Q000098:blood supply* / Q000556:secondary; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D051793:Hypoxia-Inducible Factor 1; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A