title: Absorption of myo-inositol hexakisphosphate (InsP6) through the skin in humans.
abstract: In this paper, we present a pilot study of the absorption of myo-inositol hexakisphosphate (InsP6) through the skin in humans. We found that, after topical treatment with a 4% InsP6 rich gel, InsP6 urinary excretion increased 54% compared to the control situation (participants submitted to an InsP6-poor diet for 15 days, n = 6), clearly demonstrating that InsP6 is absorbed through the skin of humans. These results demonstrate the topical application as a suitable administration route of InsP6 in humans.
authors.affiliation: Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research, Faculty of Sciences, University of Balearic Islands, 07122 Palma de Mallorca, Spain. fgrases@uib.es
authors.forename: F
authors.initials: F
authors.lastname: Grases
authors.forename: B
authors.initials: B
authors.lastname: Isern
authors.forename: J
authors.initials: J
authors.lastname: Perelló
authors.forename: P
authors.initials: P
authors.lastname: Sanchis
authors.forename: R M
authors.initials: RM
authors.lastname: Prieto
authors.forename: A
authors.initials: A
authors.lastname: Costa-Bauzà
mesh_terms: D000287:Administration, Topical; D000328:Adult; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D010833:Phytic Acid / Q000493:pharmacokinetics* / Q000652:urine; D012869:Skin Absorption / Q000502:physiology*
chemical_list: D010833:Phytic Acid