Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome.
Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems play a role in the etiology of FMS. These polymorphisms are not specific for FMS and are associated with other functional somatic disorders and depression. Future genetic studies in the field of FMS and related conditions should be conducted in larger cohorts of patients and ethnically matched control groups.
Buskila
Dan
D
Department of Medicine H, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel. dbuskila@bgumail.bgu.ac.il
Sarzi-Puttini
Piercarlo
P
D002394:Catechol O-Methyltransferase / Q000235:genetics; D005356:Fibromyalgia / Q000235:genetics* / Q000628:therapy*; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
D006680:HLA Antigens; D044402:Receptor, Serotonin, 5-HT2A; D050486:Serotonin Plasma Membrane Transport Proteins; D002394:Catechol O-Methyltransferase