title: C-type natriuretic peptide is specifically augmented by pituitary adenylate cyclase-activating polypeptide in rat astrocytes.
abstract: In rat-cultured astrocytes, pituitary adenylate cyclase-activating polypeptide (PACAP) activates gene expression and secretion of C-type natriuretic peptide (CNP) in a dose- and time-dependent manner. These results suggest that PACAP might be involved in the regulation of CNP biosynthesis in astrocytes.
authors.affiliation: Department of Pharmacology, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, 890-8544, Japan.
authors.forename: Kohsho
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nagayama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Inoue
authors.forename: Naoto
authors.initials: N
authors.lastname: Minamino
authors.forename: Kenji
authors.initials: K
authors.lastname: Kangawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Niiro
authors.forename: Atsuro
authors.initials: A
authors.lastname: Miyata
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000378:metabolism*; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D020098:Natriuretic Peptide, C-Type / Q000235:genetics* / Q000378:metabolism; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000494:pharmacology*; D051381:Rats
chemical_list: D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D020098:Natriuretic Peptide, C-Type