title: Etanercept for the treatment of psoriasis in the elderly.
abstract: This study's objective was to analyze the effect of etanercept on Psoriasis Area and Severity Index (PASI) 50, PASI 75, and Dermatology Life Quality Index in geriatric and nongeriatric populations. We conducted a post hoc analysis of two large phase III randomized placebo trials of etanercept. There were no statistically significant differences between the elderly and young with regard to the number of patients reaching a PASI 50 or PASI 75 at any of the 3 dosing regimens. Baseline Dermatology Life Quality Index scores were not statistically significant between both groups and both the elderly and young had similar changes in Dermatology Life Quality Index with therapy. A limitation of the study was the small number of patients in the elderly group. In conclusion, psoriasis and its treatment has a similar impact on quality of life in the elderly as it does in the young.
authors.affiliation: University of Pennsylvania Department of Dermatology, Philadelphia 19104, USA.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Militello
authors.forename: Amy
authors.initials: A
authors.lastname: Xia
authors.forename: Seth R
authors.initials: SR
authors.lastname: Stevens
authors.forename: Abby S
authors.initials: AS
authors.lastname: Van Voorhees
mesh_terms: D000368:Aged; D000375:Aging; D017326:Clinical Trials, Phase III as Topic; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000503:physiopathology; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D000068800:Etanercept