[Comparative study of the antiarrhythmic activity of magnesium aspartate L-, D- and DL-aspartate stereoisomers].
It seems an established fact that magnesium (Mg) aspartate is effective in prophylaxis and adjuvant therapy of cardiac arrhythmia (e.g. prevention of toxic symptoms during therapy with digoxin). There are claims that L-aspartate salts are better delivery forms for cations such as Mg than D-aspartate salts, and Mg L-aspartate can be more beneficial in the treatment of several forms of primary Mg deficiency than Mg DL- and D-aspartate. Therefore, the purposes of the present work were to compare of antiarrhythmic action of Mg L-, D- and DL-aspartate stereoisomers using CaCl(2)- and aconitine-induced arrhythmia models in rats. It was found that intravenously administered Mg L-aspartate exhibited higher activity compared to Mg D- and DL-aspartate in calcium chloride and aconitine-induced arrhythmias. In rats with arrhythmias induced by calcium chloride Mg L-aspartate compared with Mg D-aspartate and Mg DL-aspartate produced greater decrease of incidence of arrhythmias, increase of time first arrhythmia onset, decrease of percentage of rats that died and increase of duration of life after onset of first arrhythmia. In rats with aconitine-induced arrhythmia Mg L-aspartate surpassed Mg D-aspartate and Mg DL-aspartate in parameters of acute toxicity (LD(50)), effective dose (ED(50)) and antiarrhythmic (therapeutic) ratio (LD(50)/ED(50)).
D031841:Aconitum / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry* / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001224:Aspartic Acid / Q000737:chemistry* / Q000627:therapeutic use*; D002122:Calcium Chloride / Q000633:toxicity; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D000889:Anti-Arrhythmia Agents; D001224:Aspartic Acid; D002122:Calcium Chloride