Changes of serum and tissue amoxicillin levels following chlorpromazine administration in rats.
Patients under treatment with chlorpromazine (CPZ) may need antibacterial administration. Amoxicillin is the most widely used antibacterial agent in dental infections. The aim of this study was to investigate the possible interactions between amoxicillin and CPZ and the eventual changes in amoxicillin levels using an experimental model in rats. Thirty male Wistar rats weighing 200-260 g were used for this study. They were divided into three groups: group A taking 15 mg/kg amoxicillin every 8 h for 4 days; group B taking amoxicillin as group A, and 1.07 mg/kg CPZ every 8 h for 4 days; and group C taking only CPZ in the same dose as group B. Drugs were given per os for 4 days, using a special catheter. The rats were sacrificed 2 h after the last dose. Antibacterial levels were estimated in blood serum, jaw bones, tongue and liver. An increase in the level of amoxicillin in serum as well as in tissues was observed in group B. No significant antibacterial activity of CPZ was detected. The increase in amoxicillin concentration in serum and jaws of group B was statistically significant in relation to group A.
Melakopoulos
I
I
Department of Experimental Pharmacology, Medical School, University of Athens, Greece.
Tesseromatis
C
C
Saranteas
T
T
Karabinos
I
I