Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias.
OBJECTIVE
To describe recent studies on Krüppel-like factor transcription factors and their relationship with gastrointestinal neoplasias, in particular pancreatic cancer.


RESULTS
Krüppel-like factor proteins are a subfamily of transcription factors characterized by the presence of a conserved DNA-binding domain comprising three Krüppel-like zinc fingers. Each distinct family member differs in its ability to regulate transcription, and, as a consequence, to influence cellular processes including cell growth and differentiation. Recently, a number of publications have provided evidence of the implication of Krüppel-like factor proteins in gastrointestinal carcinogenesis.


CONCLUSIONS
This article will focus on the results of studies in the field published in the last year.
Buttar
Navtej S
NS
Gastroenterology Research Unit, Saint Mary's Hospital, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Fernandez-Zapico
Martin E
ME
Urrutia
Raul
R
D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*
D051741:Kruppel-Like Transcription Factors