title: Evaluation of blood flow in the ophthalmic artery and central retinal artery in children with retinopathy of prematurity.
abstract: OBJECTIVE
  To evaluate blood flow parameters in the ophthalmic artery and central retinal artery in children with retinopathy of prematurity (ROP).
  
  
  METHODS
  The study comprised 57 premature children born between 24 and 33 weeks of gestation, with birth weight from 600 g to 1660 g, including 42 preterm children with retinopathy in stage 1, 2, 3 and 3 "plus" and 15 preterm children without retinopathy. Color Doppler ultrasonography (USG-CD) was used to measure in the studied vessels maximal systolic velocity (Vmax), end-diastolic velocity (Vmin) and resistance index (RI).
  
  
  RESULTS
  Statistically significantly (p < 0.05) higher values of Vmax were seen in the ophthalmic artery and central retinal artery in preterm children with retinopathy in stage 2 and 3, as compared with other children. In preterms with dilation and tortuosity of posterior blood vessels in stage 3 "plus" ROP Vmax in both studied vessels was lower and was comparable to that in stage 1 ROP and in children without retinopathy. RI in the ophthalmic artery in children with ROP in stage 2 and 3 was statistically significantly higher (p < 0.05) from its values seen in other groups, and for the central retinal artery RI did not differ statistically significantly.
  
  
  CONCLUSIONS
  The conducted USG-CD measurements revealed that in children with retinopathy of prematurity haemodynamic parameters of blood flow in the ophthalmic artery and central retinal artery differ in relation to disease stage of advancement, and in relation to the status of blood vessels in the eye fundus. The clinical implications of these results, however, need to be confirmed in long term studies, in order to determine the sensitivity, specificity and repeatability of this method, as well as to establish the diagnostic standards.
authors.affiliation: Department of Paediatric Ophthalmology, Medical University of Lódź, University Hospital No 4.
authors.forename: Anna
authors.initials: A
authors.lastname: Niwald
authors.forename: Mirosława
authors.initials: M
authors.lastname: Grałek
mesh_terms: D000704:Analysis of Variance; D001724:Birth Weight; D001783:Blood Flow Velocity; D005123:Eye / Q000098:blood supply*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging*; D012161:Retinal Artery / Q000000981:diagnostic imaging*; D012178:Retinopathy of Prematurity / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D018615:Ultrasonography, Doppler, Color