Susceptibility of vaginal bacteria to metronidazole and tinidazole.
In vitro antimicrobial susceptibility testing was performed on 470 vaginal isolates from women with bacterial vaginosis and three species of Lactobacillus, to metronidazole and tinidazole using the agar dilution method. There was no significant difference observed in the inhibitory activity of either drug to any of the isolates tested.
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Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA. rsimna@mwri.magee.edu
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Hillier
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D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D005260:Female; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects; D006092:Gram-Negative Facultatively Anaerobic Rods / Q000187:drug effects; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D014011:Tinidazole / Q000494:pharmacology*; D014621:Vagina / Q000382:microbiology*; D016585:Vaginosis, Bacterial / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; D014011:Tinidazole; D008795:Metronidazole