title: Zonal origin of localized prostate cancer does not affect the rate of biochemical recurrence after radical prostatectomy.
abstract: OBJECTIVE
  To investigate whether transition zone (TZ) prostate cancers demonstrate different rates of biochemical recurrence after radical prostatectomy compared to peripheral zone (PZ) cancers.
  
  
  METHODS
  In 1262 consecutive patients treated with radical prostatectomy, computerized planimetry defined tumour origin as either TZ tumours (>70% TZ location) or PZ. Kaplan-Meier and multivariate Cox regression models tested the association between zonal origin and the rate of biochemical recurrence (prostate-specific antigen >0.1ng/ml and rising). We used the Harrell's concordance index to quantify the accuracy of various Cox regression models.
  
  
  RESULTS
  TZ prostate cancers were diagnosed in 115 patients (9.1%). Biochemical recurrence was recorded in 16 TZ and in 201 PZ prostate cancers patients. In multivariate Cox models, the rate of biochemical recurrence was not significantly different between TZ and PZ prostate cancers (p=0.4). Combined multivariate predictive accuracy of biochemical recurrence predictions was 81.2% accurate when zonal origin was included versus 81.0% when zonal origin was omitted.
  
  
  CONCLUSIONS
  The zonal origin of prostate cancers does not affect the rate of biochemical recurrence after radical prostatectomy.
authors.affiliation: Department of Urology, University of Hamburg, Hamburg, Germany.
authors.forename: Felix K-H
authors.initials: FK
authors.lastname: Chun
authors.forename: Alberto
authors.initials: A
authors.lastname: Briganti
authors.forename: Claudio
authors.initials: C
authors.lastname: Jeldres
authors.forename: Andreas
authors.initials: A
authors.lastname: Erbersdobler
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schlomm
authors.forename: Thomas
authors.initials: T
authors.lastname: Steuber
authors.forename: Andrea
authors.initials: A
authors.lastname: Gallina
authors.forename: Jochen
authors.initials: J
authors.lastname: Walz
authors.forename: Paul
authors.initials: P
authors.lastname: Perrotte
authors.forename: Hartwig
authors.initials: H
authors.lastname: Huland
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
mesh_terms: D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000453:epidemiology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D013997:Time Factors
chemical_list: D017430:Prostate-Specific Antigen