[The effect of glycine with timoptol on the rabbit IOP physiological values].
OBJECTIVE
the mixture of 10% L-glycine.HCl in 0.5% Timoptol, intensity and duration of effect on the physiological IOP is evaluated in this work.


METHODS
Experiments were performed on 5 rabbits of the New Zealand White species. The mixture and its components were individually instilled into the left conjunctival sac. The right eye was used as control.


RESULTS
after instillation of the 10% L-glycine.HCl and 0.5% Timoptol mixture the IOP showed significant decrease compared with the control eye during 24 hour evaluation. Maximal decrease for 33% (8.5 torr) was measured in 60th min., compared with the decrease for 30.5% (7.6 torr) in 120th and for 28% in 30th min. On the contrary, both substances alone--the 10% L-glycine.HC1 and 0.5% Timoptol decrease the physiological IOP values only no significantly compared with their mixture and the control eyes. The mean value of the pupilar diameter was 7.8 mm on both eyes.


CONCLUSIONS
We assume that the decrease of the physiological IOP value is caused by a new metabolite--the "bioantiglaucomatic" created by interaction of glycine and Timoptol in vitro. The effect of this mixture on the decrease of the physiological IOP values is 8-times stronger compared with Timoptol and 4.3-times stronger compared with glycine. Application of such already prepared bioantiglaucomatic in the clinical practice can contribute to the more effective, safe and reliable therapeutic effect on the IOP in glaucomatic disease.
Veselovský
J
J
Katedra zivocísnej fyziológie a etológie PriF UK, Bratislava, SR.
Oláh
Z
Z
Veselá
A
A
Gressnerová
S
S
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D004338:Drug Combinations; D005998:Glycine / Q000008:administration & dosage* / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D009883:Ophthalmic Solutions; D011817:Rabbits; D013999:Timolol / Q000008:administration & dosage* / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D013999:Timolol; D005998:Glycine