title: [Potential open reading frames within 5'-untranslated regions of eukaryotic mRNAs].
abstract: It is known that 5'-untranslated sequences of eukaryotic mRNA often contain AUG triplets, which may serve as the sites of translation initiation. It is thought that these leader open reading frames can fulfil the regulatory functions and encode functionally active proteins. However, they have been incompletely characterized. The article deals with the context organization of leader reading frames of eukaryotic mRNAs. It has been shown that their characteristics correlate with the position relative to the protein-encoding sequence, which may be associated with the efficiency of initiation of translation.
authors.forename: O A
authors.initials: OA
authors.lastname: Volkova
authors.forename: A V
authors.initials: AV
authors.lastname: Kochetov
authors.forename: S E
authors.initials: SE
authors.lastname: Titov
authors.forename: N A
authors.initials: NA
authors.lastname: Kolchanov
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics*; D000818:Animals; D017360:Arabidopsis / Q000235:genetics; D018387:Codon, Initiator / Q000235:genetics; D005057:Eukaryotic Cells; D006801:Humans; D016366:Open Reading Frames / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D017423:Sequence Analysis, RNA / Q000379:methods; D012984:Software
chemical_list: D020121:5' Untranslated Regions; D018387:Codon, Initiator; D011506:Proteins