title: High-throughput genomic technology in research and clinical management of breast cancer. Molecular signatures of progression from benign epithelium to metastatic breast cancer.
abstract: It is generally accepted that early detection of breast cancer has great impact on patient survival, emphasizing the importance of early diagnosis. In a widely recognized model of breast cancer development, tumor cells progress through chronological and well defined stages. However, the molecular basis of disease progression in breast cancer remains poorly understood. High-throughput molecular profiling techniques are excellent tools for the study of complex molecular alterations. By accurately mapping changes in the genome and subsequent biological/molecular pathways, the chances of finding potential novel treatment targets as well as intervention strategies are enhanced, and ultimately lives can be saved. This review provides a brief summary of recent progress in identifying molecular markers for invasiveness in early breast lesions.
authors.affiliation: Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden. Karin.Rennstam@med.lu.se
authors.forename: Karin
authors.initials: K
authors.lastname: Rennstam
authors.forename: Ingrid
authors.initials: I
authors.lastname: Hedenfalk
mesh_terms: D001940:Breast / Q000503:physiopathology; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics / Q000473:pathology; D018275:Carcinoma, Lobular / Q000235:genetics / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D018450:Disease Progression; D004848:Epithelium / Q000503:physiopathology; D005260:Female; D020869:Gene Expression Profiling; D005821:Genetic Techniques; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics; D011230:Precancerous Conditions / Q000235:genetics / Q000473:pathology; D012106:Research