title: Osteomyelitis in horses.
abstract: Much has been learned in the past decade about osteomyelitis. The inhibitory mechanisms of the "biofilm slime" layer that is formed by bacterial extracapsular exopolysaccharides and binds to bone, joints, and implants are now better understood than in the past. The surface colonization of bacteria that occurs within these biofilms is a biologic phenomenon that is somewhat unique to orthopedic infections. This survival strategy of bacteria is effective, and it is important for veterinarians who treat osteomyelitis to be aware of current diagnostic and therapeutic treatment modalities. The practitioner should be aware of the most common bacteria associated with osteomyelitis and the traditional treatments that are still used. Current therapeutic treatment modalities, such as antibiotic- impregnated polymethylmethacrylate, antibiotic-impregnated plaster of Paris, and regional perfusion, have become routine, however, and have been responsible for improving the prevention and outcome of osteomyelitis in the horse. It is the intent of this article to make equine veterinarians aware of current information as well as the future treatments of osteomyelitis.
authors.affiliation: College of Veterinary Medicine, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA. laurie.goodrich@colostate.edu
authors.forename: Laurie R
authors.initials: LR
authors.lastname: Goodrich
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D016025:Bone Transplantation / Q000662:veterinary; D003475:Curettage / Q000662:veterinary; D006734:Horse Diseases / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D006736:Horses; D010019:Osteomyelitis / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy / Q000662:veterinary*; D010477:Perfusion / Q000662:veterinary; D011183:Postoperative Complications / Q000662:veterinary; D035703:Therapies, Investigational / Q000662:veterinary
chemical_list: D000900:Anti-Bacterial Agents