title: Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy.
abstract: BACKGROUND
  We investigated the change of prognosis in resected gastric cancer (RGC) patients and the role of radical surgery and adjuvant chemotherapy.
  
  
  METHODS
  We retrospectively analyze the outcome of 426 consecutive patients from 1975 to 2002, divided into 2 time-periods (TP) cohort: Before 1990 (TP1, n = 207) and 1990 or after (TP2; n= 219). Partial gastrectomy and D1-lymphadenectomy was predominant in TP1 and total gastrectomy with D2-lymphadenectomy it was in TP2. Adjuvant chemotherapy consisted of mitomycin C (MMC), 10-20 mg/m2 i.v. 4 courses or MMC plus Tegafur 500 mg/m2 for 6 months.
  
  
  RESULTS
  Positive nodes were similar in TP2/TP1 patients with 56%/59% respectively. Total gastrectomy was done in 56%/45% of TP2/TP1 respectively. Two-drug adjuvant chemotherapy was administered in 65%/18% of TP2/TP1 respectively. Survival at 5 years was 66% for TP2 versus 42% for TP1 patients (p < 0.0001). Survival by stages II, IIIA and IIIB for TP2 versus TP1 patients was 70 vs. 51% (p = 0.0132); 57 vs. 22% (p = 0.0008) and 30 vs. 15% (p = 0.2315) respectively. Multivariate analysis showed that age, stage of disease and period of treatment were independent variables.
  
  
  CONCLUSIONS
  The global prognosis and that of some stages have improved in recent years with case RGC patients treated with surgery and adjuvant chemotherapy.
authors.affiliation: Oncology Department, Institut Clinic de Malalties Hemato-Oncologiques, University of Barcelona, Hospital Clinic, Barcelona, Spain. jjgrau@clinic.ub.es
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Grau
authors.forename: Ramon
authors.initials: R
authors.lastname: Palmero
authors.forename: Maribel
authors.initials: M
authors.lastname: Marmol
authors.forename: Jose
authors.initials: J
authors.lastname: Domingo-Domenech
authors.forename: Mariano
authors.initials: M
authors.lastname: Monzo
authors.forename: Jose
authors.initials: J
authors.lastname: Fuster
authors.forename: Oscar
authors.initials: O
authors.lastname: Vidal
authors.forename: Constantino
authors.initials: C
authors.lastname: Fondevila
authors.forename: Juan C
authors.initials: JC
authors.lastname: Garcia-Valdecasas