Statins for the prevention of perioperative cardiovascular complications in vascular surgery.
Perioperative cardiovascular complications in vascular surgery remain a significant problem despite recent advancements in perioperative care. This clinical update summarizes the results of recent studies on the effectiveness and safety of perioperative statin use for the prevention of these perioperative cardiovascular complications. Five studies in patients undergoing major noncardiac vascular surgery and two studies in patients undergoing carotid endarterectomy are described. All studies reported a significant reduction in perioperative cardiovascular events in statin users compared with nonusers. The safety of perioperative statin use has not yet been fully elaborated, although current evidence suggests there is no extra risk from statin-induced side effects in the perioperative period.
Schouten
Olaf
O
Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.
Bax
Jeroen J
JJ
Dunkelgrun
Martin
M
Feringa
Harm H
HH
van Urk
Hero
H
Poldermans
Don
D
D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D016894:Endarterectomy, Carotid / Q000009:adverse effects; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019990:Perioperative Care; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors