ErbB2 makes beta 4 integrin an accomplice in tumorigenesis.
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not clear. Guo et al. (2006) now demonstrate that alpha 6 beta 4 integrin cooperates with ErbB2 in the formation of mammary tumors and discover distinct pathways that regulate cellular proliferation and adhesion downstream of the ErbB2-integrin complex.
Muthuswamy
Senthil K
SK
One Bungtown Road, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. muthuswa@cshl.edu
D000818:Animals; D002277:Carcinoma / Q000378:metabolism* / Q000503:physiopathology; D002448:Cell Adhesion / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D039161:Integrin alpha6beta4 / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D019108:Tight Junctions / Q000378:metabolism
D039161:Integrin alpha6beta4; D018719:Erb-b2 Receptor Tyrosine Kinases