Colloidal stability of pluronic F68-coated PLGA nanoparticles: a variety of stabilisation mechanisms.
Poloxamers are a family of polypropylene oxide (PPO) and polyethylene oxide (PEO) tri-block copolymers that are usually employed in the micro- and nanoparticulate engineering for drug delivery systems. The aim of this work is to study the electrophoretic mobility (mu(e)) and colloidal stability of complexes formed by adsorbing a poloxamer (Pluronic F68) onto poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles. A variety of stabilisation mechanisms have been observed for the Pluronic-coated PLGA nanoparticles, where DLVO interactions, solvent-polymer segment interactions and hydration forces play different roles as a function of the adsorbed amount of Pluronic. In addition, the mu(e) and stability data of these complexes have been compared to those obtained previously using a PLGA-Pluronic F68 blend formulation. As both the mu(e) and the stability data are identical between the two systems, a phase separation of both components in the PLGA-Pluronic blend formulation is suggested, being the PLGA located in the core of the particles and the Pluronic in an adsorbed shell.
Santander-Ortega
M J
MJ
Biocolloid and Fluid Physics Group, Department of Applied Physics, University of Granada, Av. Fuentenueva S/N, 18071, Granada, Spain.
Jódar-Reyes
A B
AB
Csaba
N
N
Bastos-González
D
D
Ortega-Vinuesa
J L
JL
D000327:Adsorption; D002122:Calcium Chloride / Q000737:chemistry; D003102:Colloids; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D013499:Surface Properties
D003102:Colloids; D011108:Polymers; D020442:Poloxamer; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012965:Sodium Chloride; D002122:Calcium Chloride