Dopamine and reward: comment on Hernandez et al. (2006).
Many lines of evidence suggest that the dopaminergic projection from the midbrain tegmentum to the forebrain must play a critical role in mediating the behavioral effects of natural and artificial rewards, with brain stimulation reward and addictive drugs included in the latter category. However, a closer look reveals many incongruities. The work of G. Hernandez et al. (2006) resolves several puzzles. It implies that the dopaminergic projection does not carry the signal that encodes the magnitude of a brain stimulation reward. It suggests that the elevation in the tonic levels of dopamine consequent on brain stimulation reward modulates the registration of the magnitude of the reward. This reconciles the psychophysical evidence with the pharmacological, electrophysiological, and anatomical evidence. However, some serious puzzles do remain.
Gallistel
C R
CR
Department of Psychology and Center for Cognitive Science, Rutgers University, Piscataway, NJ 08854-8020, USA. galliste@ruccs.rutgers.edu
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D012201:Reward
D004298:Dopamine