title: [Changes of trace elements in regional lymph nodes of gastric carcinoma].
abstract: OBJECTIVE
  To explore the relationship between the changes of trace elements and lymphatic metastasis in gastric carcinoma.
  
  
  METHODS
  Trace elements including Fe, Mg, Mn, Ca, Cu, Zn, Se were measured in primary gastric carcinoma and regional lymph nodes from 40 patients with gastric carcinoma, and compared among the primary tumor, metastatic, and non-metastatic nodes.
  
  
  RESULTS
  There were no significant differences in the contents of Fe, Mg, Mn and Ca among primary gastric tumors, regional lymph nodes with or without metastasis (P=0.372 - 0.741, P > 005), and no significant differences in the contents of all 7 trace elements between primary tumors and metastatic lymph nodes (P=0.15 - 0.59, P > 005). Compared with metastatic lymph nodes, the contents of Zn, Se significantly decreased, while Cu and Cu/Zn significantly increased (P=0.001 - 0.009, P< 0.01) in non-metastatic lymph nodes. The content of Zn in N2 positive lymph nodes was significant lower than that in N1 positive nodes (P=0.027). There were no significant difference in the contents of all 7 elements between intestinal type and diffuse type (P=0.149 - 0.758, P > 0.05).
  
  
  CONCLUSIONS
  Lymphatic metastasis of gastric cancer is concomitant with the changes of trace elements, and the changes of Zn, Cu, Se may be related with lymphatic metastasis.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China. 65166066@163.com
authors.forename: Jing-cheng
authors.initials: JC
authors.lastname: Zhang
authors.forename: Guang-zhao
authors.initials: GZ
authors.lastname: Li
authors.forename: Yun-sheng
authors.initials: YS
authors.lastname: Huang
authors.forename: Wen-ying
authors.initials: WY
authors.lastname: Shen
authors.forename: Chao-yang
authors.initials: CY
authors.lastname: Qi
authors.forename: Chun-lai
authors.initials: CL
authors.lastname: Chen
authors.forename: Xing-hong
authors.initials: XH
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D014131:Trace Elements / Q000378:metabolism*
chemical_list: D014131:Trace Elements