Novel seco-dibenzopyrrocoline alkaloid from Cryptocarya oubatchensis.
[structure: see text] A novel seco-dibenzopyrrocoline alkaloid, named oubatchensine 6, and five phenanthroindolizidines (1-5) were isolated from Cryptocarya oubatchensis, and their structures were elucidated. Displacement centrifugal partition chromatography was used to purify compounds 1 and 6. Structure determination of the latter was carried out by mass spectrometry, NMR spectroscopy, quantum chemistry, and computer-assisted structure determination. Cytotoxic activity against KB cells was then investigated.
Toribio
Alix
A
FRE 2715 (IFR 53), UMR 6519, and UMR 6089, Université de Reims Champagne-Ardenne, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France.
Bonfils
Aurélie
A
Delannay
Eldra
E
Prost
Elise
E
Harakat
D
D
Henon
Eric
E
Richard
Bernard
B
Litaudon
Marc
M
Nuzillard
Jean-Marc
JM
Renault
Jean-Hugues
JH
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031369:Cryptocarya / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; C520161:oubatchensine