The evolving story of the omega subunit of bacterial RNA polymerase.
Omega (omega) is the smallest subunit of bacterial RNA polymerase (RNAP). Although identified early in RNAP research, its function remained ambiguous and shrouded by controversy for a considerable period. It has subsequently been shown that the protein has a structural role in maintenance of the conformation of the largest subunit, beta', and recruitment of beta' to the enzyme assembly. Conservation of this function across all forms of life indicates the importance of its role. Several recent observations have suggested additional functional roles for this protein and have settled some long-standing controversies surrounding it. In this context, revisiting the omega subunit story is especially interesting; here, we review the progress of omega research since its discovery and highlight the importance of these recent observations.
Mathew
Renjith
R
Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, India.
Chatterji
Dipankar
D
D001419:Bacteria / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D011487:Protein Conformation; D012808:Sigma Factor / Q000378:metabolism
D001426:Bacterial Proteins; D012808:Sigma Factor; C111232:RNA polymerase omega subunit; C108570:beta' subunit of RNA polymerase; D012321:DNA-Directed RNA Polymerases