[Glomerulonephritis with organized immunoglobulin deposits].
Glomerulonephritis with organized immunoglobulin deposits are heterogeneous and may be encountered in a variety of renal disorders. It is particularly important to determine the exact types of immunoglobulin deposited and their monotypy/monoclonality, using specific anti-light chain conjugates and in some instances, anti-heavy chain subclass conjugates. The histologic pattern and identification of monotypic Ig deposits in renal tissue are in some cases sufficient for the diagnosis of AL amyloidosis, type I cryoglobulinic glomerulonephritis or "Randall-type" monoclonal immunoglobulin deposition disease (MIDD). Electron microscopy is particularly valuable for the precise localization of Ig deposits and for determing the pattern of deposition: organized, homogeneous (non-organized or granular) or mixed. New entities in the broad spectrum of Ig deposition diseases are emerging from electron microscopy studies of renal diseases. We propose here a comprehensive classification for diseases featuring the organized deposition in tissues of Ig.
Touchard
Guy
G
Service de néphrologie, service d'anatomie pathologique et unité de pathologie ultrastructurale, hôpital Jean-Bernard, centre hospitalier universitaire, Poitiers, France. g.touchard@chu-poitiers.fr
Bridoux
Frank
F
Goujon
Jean-Michel
JM
D000686:Amyloidosis / Q000276:immunology* / Q000628:therapy; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008870:Microtubules / Q000276:immunology / Q000473:pathology
D007143:Immunoglobulin Heavy Chains; D007136:Immunoglobulins