Influence of different treatment approaches on non-submerged and submerged healing of ligature induced peri-implantitis lesions: an experimental study in dogs.
OBJECTIVE
[corrected] The aim of the present study was to evaluate non-submerged and submerged healing of ligature induced peri-implantitis in dogs.


METHODS
Peri-implantitis was induced by ligature placement in five beagle dogs (n = 30 implants). The defects were randomly and equally allocated in a split-mouth design to either closed treatment + non-submerged healing (CNS), or open treatment + submerged healing (OS) using an Er:YAG laser (ERL), an ultrasonic device (VUS), or plastic curettes + local application of metronidazole gel (PCM), respectively. The animals were sacrificed after 3 months. Clinical, radiological and histological (e.g. new bone-to-implant contact (BIC)) parameters were assessed.


RESULTS
All treatment procedures resulted in statistically significant improvements of all clinical parameters at both CNS and OS implants. Radiological improvements were merely observed at OS implants. Histomorphometrical analysis revealed that all CNS implants exhibited comparable low amounts of new BIC (1.0-1.2%), while mean BIC was statistically significant higher in the respective OS groups [ERL (44.8%), PCM (14.8%), VUS (8.7%)].


CONCLUSIONS
Within the limits of the present study, it was concluded that (i) OS improved the outcome of treatment in comparison with CNS and (ii) ERL seemed to be more suitable to promote re-osseointegration than PCM and VUS.
Schwarz
Frank
F
Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. info@frank-schwarz.de
Jepsen
Søren
S
Herten
Monika
M
Sager
Martin
M
Rothamel
Daniel
D
Becker
Jürgen
J
D000538:Aluminum Silicates; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D015921:Dental Implants / Q000009:adverse effects*; D004195:Disease Models, Animal; D004285:Dogs; D004871:Erbium; D005260:Female; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods; D008026:Ligation / Q000295:instrumentation; D008795:Metronidazole / Q000627:therapeutic use; D016348:Osseointegration / Q000502:physiology; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D010969:Plastics; D011859:Radiography; D011897:Random Allocation; D013357:Subgingival Curettage / Q000295:instrumentation; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000295:instrumentation; D014945:Wound Healing / Q000502:physiology; D015019:Yttrium
D000538:Aluminum Silicates; D000890:Anti-Infective Agents; D015921:Dental Implants; D010969:Plastics; D008795:Metronidazole; D015019:Yttrium; D004871:Erbium