title: Detection of Chlamydia trachomatis and herpes simplex virus type 1 or 2 in cervical samples in human papilloma virus (HPV)-positive and HPV-negative women.
abstract: This study investigated whether the prevalence of human papilloma virus (HPV) in association with Chlamydia trachomatis, herpes simplex virus (HSV)-1 and/or HSV-2 was greater in high-grade than in low-grade or control cervical biopsy specimens. HPV-positive (n = 86) and HPV-negative (n = 213) women were screened for HPV, HSV and C. trachomatis by PCR. The most common HPV genotypes were HPV-16, HPV-6 and HPV-33; mixed HPV infection (n = 12) was also seen. A higher prevalence of C. trachomatis, HSV-1 and HSV-2 was found in HPV-positive samples. High-risk HPV genotypes and combined HPV + C. trachomatis or HPV + HSV-1, but not HSV-2, infections were associated with a greater risk of developing cervical carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, St Georges University Hospital, Beirut, Lebanon.
authors.forename: R R
authors.initials: RR
authors.lastname: Finan
authors.forename: U
authors.initials: U
authors.lastname: Musharrafieh
authors.forename: W Y
authors.initials: WY
authors.lastname: Almawi
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000453:epidemiology / Q000382:microbiology / Q000821:virology; D002584:Cervix Uteri / Q000382:microbiology* / Q000821:virology*; D002690:Chlamydia Infections / Q000453:epidemiology / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D005260:Female; D005838:Genotype; D006558:Herpes Genitalis / Q000453:epidemiology / Q000821:virology; D006561:Herpes Simplex / Q000453:epidemiology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000382:microbiology / Q000821:virology