[Analysis of the factors affecting the recurrence of giant cell tumor of bone].
OBJECTIVE
To analyze the clinical factors affecting the recurrence of giant cell tumors (GCT) of bone.


METHODS
The complete data of 146 cases with GCT were reviewed. Thirteen clinical factors were analyzed by chi(2) analysis. And the related Campanacci's grade system and Jaffe's grade system was analyzed by Crosstabs analysis. Multipal factors were analyzed by Logistic regression analysis.


RESULTS
Nineteen of 146 cases recurred, and recurrence rate was 13.0%. Recurrence rates of curettage and enblock resection groups were 18.8% and 6.3% respectively. And recurrence rates of curettage with or without of extensive procedure were 12.9% and 38.9%. Five cases had lung metastasis, and two cases presented with malignant transformation. The metastasis rate and the rate of malignant transformation were 3.4% and 1.4% respectively. The two factors of surgery method and burst out of bone-envelope appearance were related with the recurrence. Moreover, Logistic regression revealed that the surgery method significantly affected the recurrence. And Campanacci's grade system and Jaffe's grade system were not related to each other.


CONCLUSIONS
Surgery method is the main factor affected the recurrence of GCT, and Campanacci's grade system or Jaffe's grade system has no prognostic value.
Guo
Qian-chen
QC
Department of Orthopedics, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Shen
Jing-nan
JN
Wang
Jin
J
Huang
Gang
G
Zou
Chang-ye
CY
Jin
Song
S
Yin
Jun-qiang
JQ
Liao
Wei-ming
WM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery; D005163:Factor Analysis, Statistical; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000601:surgery; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D012307:Risk Factors