[Skin neuroendocrine carcinoma metastasis: a case report].
BACKGROUND
Merkel cell carcinoma (MCC) is a rare and aggressive skin tumour with a highly malignant nature whose appropriate treatment is still debated. The Authors report a case of cutaneous metastasis from neuroendocrine carcinoma and analyse new diagnostic and therapeutic options of neoplasms that occurs in sun-exposed areas.


METHODS
The authors present the clinical, immunocytochemical characteristic of primary and secondary skin localization of a neuroendocrine tumor that affected a woman.


RESULTS
Histological and immunocytochemical analysis demonstrated that the secondary cutaneous localization appeared to be compared to the primary tumour.


CONCLUSIONS
The case confirm the high incidence of regional metastasis; a wide surgical excision of tumor and regional lymphadenectomy is therefore recommended for primary treatment of MCC; the radiation treatment minimized the local recidives with long time survival.
Rossitto
Maurizio
M
Dipartimento di Patologia Umana, Universit, degli Studi di Messina, Azienda Ospedaliera Universitaria, Policlinico G. Martino, Messina. rossitt@unime.it
Fedele
Francesco
F
Pantè
Sebastiano
S
Crescenti
Fabio
F
Incardona
Salvatore
S
Ciccolo
Antonio
A
Famulari
Ciro
C
D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D011859:Radiography; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D014463:Ultrasonography