title: [Pulmonary artery wedge pressure and heart rate measurement during pharmacological stress induction for left cardial function diagnosis in horses with and without heart disease].
abstract: In 18 horses, the pulmonary artery wedge pressure and the heart rate were measured during pharmacological stress load. 12 horses were healthy (4 trained, 8 untrained) and 6 horses had a heart disease (3 trained, 3 untrained). Pharmacological stress induction was carried out with the sympathomimetic drug dobutamine at a dosage rate of 7.5 microg/kg/min over 10 minutes of infusion. At the fourth minute, the parasympatholytic drug atropine was administered (5 microg/kg bw), and the heart rate and the pulmonary artery wedge pressure were continuously measured over 26 minutes. During sole dobutamine infusion, a significant decrease in heart rate and a significant increase in pulmonary artery wedge pressure were observed. After the application of atropine in the fourth minute, a significant increase in heart rate (from 35.7 +/- 6 up to 106 +/- 38/ min) and in pulmonary artery wedge pressure (from 15.7 +/- 3 up to 24 +/- 8.6 mmHg) were visible in the group of healthy horses. The horses with heart diseases had a significantly higher increase in both parameters (heart rate and pulmonary artery wedge pressure) with a significantly positive correlation (r = 0.7). The heart rate increased in the horses with heart diseases from 35.2 +/- 2,8 beats/min up to 132 +/- 45.7 beats/min and the pulmonary artery wedge pressure increased from 17.3 +/- 3,2 mmHg up to 32.7 +/- 13 mmHg. The cardiac status (healthy or heart disease) as well as the training level of the horses (untrained or trained) had a significant influence on the heart rate and the pulmonary artery wedge pressure. The untrained horses (healthy and heart disease) showed significantly higher values over a longer period of time than did the trained horses with the same cardiac status. Additionally the influence of pharmacological stress induction on echocardiographic parameters was investigated. The left atrial size (p = 0.015) and left ventricular diameter were significanly different in the systole (p = 0.008) and in the diastole (p = 0.001) between healthy horses and horses with heart diseases. All horses showed a positive correlation between the pulmonary artery wedge pressure and the left atrial size (r = 0.8), as well as between the left ventricular systolic (r = 0.6) and the diastolic diameter (r = 0.6). The correlation between the pulmonary artery wedge pressure and the left atrial size was nearly the same in the healthy horses (r = 0.74) and in the horses with heart diseases (r = 0.76). Regarding the training level, all untrained horses had a significantly higher correlation between the pulmonary artery wedge pressure and the left atrial size (r = 0.87) in comparison to the trained horses (r = 0.74). Particularly in the untrained horses with heart diseases, this correlation was remarcable (r = 0.99).
authors.affiliation: Klinik für Pferde. Stiftung Tierärztliche Hochschule Hannover. heidrun.gehlen@tiho-hannover.de
authors.forename: H
authors.initials: H
authors.lastname: Gehlen
authors.forename: U
authors.initials: U
authors.lastname: Groner
authors.forename: K
authors.initials: K
authors.lastname: Rohn
authors.forename: P
authors.initials: P
authors.lastname: Stadler
mesh_terms: D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000494:pharmacology; D016022:Case-Control Studies; D004280:Dobutamine / Q000008:administration & dosage / Q000494:pharmacology; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D006331:Heart Diseases / Q000503:physiopathology / Q000662:veterinary*; D006339:Heart Rate / Q000187:drug effects*; D006734:Horse Diseases / Q000139:chemically induced / Q000503:physiopathology*; D006736:Horses; D008297:Male; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects*; D013312:Stress, Physiological / Q000139:chemically induced / Q000662:veterinary*; D013566:Sympathomimetics / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
chemical_list: D002317:Cardiovascular Agents; D010276:Parasympatholytics; D013566:Sympathomimetics; D004280:Dobutamine; D001285:Atropine