title: Shift in vaginal flora (bacterial vaginosis) and the frequency of chorioamnionitis in a high-risk population.
abstract: OBJECTIVE
  To test the association between a shift in vaginal flora (SVF) and chorioamnionitis in a population with a high prevalence of both conditions.
  
  
  METHODS
  Subjects were women with Pap smears and placentas examined at the Medical Center of Louisiana, New Orleans. The presence of subchorionitis, chorionitis, chorioamnionitis and necrotizing chorioamnionitis was evaluated blindly on placental tissue sections. The presence of SVF was evaluated on matching cervical Pap smears obtained during gestation.
  
  
  RESULTS
  Three hundred twenty-two placentas and the corresponding Pap smears were examined. Chorioamnionitis was identified in 112 placentas. It was not significantly associated with maternal age or ethnicity, but its prevalence was inversely related to gestational age. SVF was observed in 114 Pap smears. It was more common among African Americans than other ethnic groups but was not significantly associated with maternal age or gestational age at delivery. SVF was more often observed in Pap smears collected in early pregnancies than in those collected later. There was no significant association between chorioamnionitis and SVF before and after accounting for ethnicity, maternal age, gestational age at Pap smear collection, and interval between Pap smear collection and delivery.
  
  
  CONCLUSIONS
  SVF had no significant predictive value for chorioamnionitis in our study population.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, Texas 77030-3498, USA. takei327@aol.com
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Takei
authors.forename: Bernardo
authors.initials: B
authors.lastname: Ruiz
mesh_terms: D000293:Adolescent; D000328:Adult; D002821:Chorioamnionitis / Q000382:microbiology*; D005006:Ethnicity; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D011247:Pregnancy; D012307:Risk Factors; D014626:Vaginal Smears; D016585:Vaginosis, Bacterial / Q000473:pathology*