Adsorption of bile acid by chitosan salts prepared with cinnamic acid and analogue compounds.
A chitosan (CS) powder treated with cinnamic acid and an analogue compound (CN) was prepared as CS-CN. Using it, bile acid adsorption by CS-CN and the release of CN were investigated in vitro. When CS-CN was soaked in a taurocholate solution, it released CN and simultaneously adsorbed the bile acid. For CS-CN prepared with cinnamic acid, the amount of CN released was 0.286 +/- 0.001 mmol/g CS-CN; the amount of taurocholate adsorbed was 0.284 +/- 0.003 mmol/g CS-CN. These two functions were recognized on alginate or pectin gel beads containing CS-CN. The amount of released CN was altered extensively by the species of CN used for gel-bead preparation. Results suggest that CS-CN is a candidate for complementary medicine to prevent lifestyle-related diseases.
Murata
Yoshifumi
Y
Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan. y-murata@hokuriku-u.ac.jp
Nagaki
Kumiko
K
Kofuji
Kyouko
K
Sanae
Fujiko
F
Kontani
Hitoshi
H
Kawashima
Susumu
S
D000327:Adsorption; D000464:Alginates / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D001647:Bile Acids and Salts / Q000737:chemistry*; D048271:Chitosan / Q000378:metabolism* / Q000493:pharmacokinetics*; D002934:Cinnamates / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry; D005750:Gastric Juice / Q000378:metabolism; D020723:Glucuronic Acid / Q000737:chemistry; D006000:Glycocholic Acid / Q000737:chemistry / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000378:metabolism; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis; D011208:Powders / Q000737:chemistry; D013656:Taurocholic Acid / Q000737:chemistry; D013657:Taurodeoxycholic Acid / Q000737:chemistry; D014641:Vanillic Acid / Q000737:chemistry; D014961:X-Ray Diffraction
D000464:Alginates; D000975:Antioxidants; D001647:Bile Acids and Salts; D002934:Cinnamates; D003373:Coumaric Acids; D006603:Hexuronic Acids; D004364:Pharmaceutical Preparations; D011208:Powders; C029010:cinnamic acid; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D013657:Taurodeoxycholic Acid; D013656:Taurocholic Acid; D020723:Glucuronic Acid; D048271:Chitosan; D006000:Glycocholic Acid; D014641:Vanillic Acid