title: Design, synthesis and diuretic activity of some novel 2,4-diamino-6-aryl-7-arylaminopyrimido [4,5-d]pyrimidin-5(6H)-ones.
abstract: Synthesis and diuretic activity of some novel 2,4-diamino-6-aryl-7-arylaminopyrimidol4,5-d]pyrimidin-5(6H) -ones were described. The series was designed on the basis of structural similarity between pteridines and pyridopyrimidines. Designed molecules were synthesized by cyclo-condensation of 5-cyano-6-methylmercapto-3-aryl-2-arylaminopyrimidin-4(3H)-one with guanidine. All the compounds were screened for their diuretic activity using triamterene and furosemide as standard drugs. Compounds 2a, 2b, 2d, 2e and 2f were found more potent than triamterene. Compound 2e exhibited diuretic activity comparable to furosemide with greater natriuretic effect. It also exhibited significant antihypertensive activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Lallubhai Motilal College of Pharmacy, Ahmedabad, India.
authors.forename: Ishwarsinh S
authors.initials: IS
authors.lastname: Rathod
authors.forename: Mahesh T
authors.initials: MT
authors.lastname: Chhabria
authors.forename: Atul S
authors.initials: AS
authors.lastname: Chaudhari
authors.forename: Mitesh H
authors.initials: MH
authors.lastname: Jani
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006439:Hemodynamics / Q000187:drug effects; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D011744:Pyrimidinones; D011188:Potassium