title: Lateral membrane waves constitute a universal dynamic pattern of motile cells.
abstract: We have monitored active movements of the cell circumference on specifically coated substrates for a variety of cells including mouse embryonic fibroblasts and T cells, as well as wing disk cells from fruit flies. Despite having different functions and being from multiple phyla, these cell types share a common spatiotemporal pattern in their normal membrane velocity; we show that protrusion and retraction events are organized in lateral waves along the cell membrane. These wave patterns indicate both spatial and temporal long-range periodic correlations of the actomyosin gel.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, New York 10027, USA. hgd@biophysik.uni-bremen.de
authors.forename: Hans-Günther
authors.initials: HG
authors.lastname: Döbereiner
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Dubin-Thaler
authors.forename: Jake M
authors.initials: JM
authors.lastname: Hofman
authors.forename: Harry S
authors.initials: HS
authors.lastname: Xenias
authors.forename: Tasha N
authors.initials: TN
authors.lastname: Sims
authors.forename: Grégory
authors.initials: G
authors.lastname: Giannone
authors.forename: Michael L
authors.initials: ML
authors.lastname: Dustin
authors.forename: Chris H
authors.initials: CH
authors.lastname: Wiggins
authors.forename: Michael P
authors.initials: MP
authors.lastname: Sheetz
mesh_terms: D000205:Actomyosin / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D005782:Gels / Q000737:chemistry; D051379:Mice; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology / Q000502:physiology*; D013997:Time Factors
chemical_list: D005782:Gels; D000205:Actomyosin