IKK epsilon signaling: not just NF-kappaB.
IkappaB kinases (IKKs) are key components of NF-kappaB signaling pathways in innate immunity and inflammation. Surprisingly, three recent reports implicate IKKs in Drosophila in seemingly unrelated functions, including non-apoptotic caspase activation and cytoskeleton organization.
Bergmann
Andreas
A
The University of Texas MD Anderson Cancer Center, Department of Biochemistry & Molecular Biology, 1515 Holcombe Blvd-Unit 1000, Houston, Texas 77030, USA. abergman@mdanderson.org
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism*; D003599:Cytoskeleton / Q000502:physiology*; D004331:Drosophila melanogaster / Q000502:physiology*; D051550:I-kappa B Kinase / Q000378:metabolism*; D034443:RNA Transport / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D051550:I-kappa B Kinase; D020169:Caspases