Anterior visual pathway gliomas: The last 30 years.
Modern neuroimaging provides excellent characterization of anterior visual pathway gliomas, often obviating the need for biopsy of the tumor. Management remains controversial, but if there is progression, chemotherapy is preferred for young patients. Stereotactically guided conformal radiotherapy and proton beam radiotherapy allow smaller, more precise doses of radiation to be administered and can be considered in older children with progressive disease. A mouse model of NF-1 with optic pathway gliomas has the potential to provide important insights into the development of gliomas as well as serving as a model for their effective treatment.
Pepin
Susan M
SM
Massachusetts Eye and Ear Infirmary, Boston, MA, USA. susan.m.pepin@hitchcock.org
Lessell
Simmons
S
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D005910:Glioma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D009456:Neurofibromatosis 1 / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D009897:Optic Chiasm / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D019574:Optic Nerve Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D020266:Radiotherapy, Conformal; D014795:Visual Pathways / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects
D000970:Antineoplastic Agents