title: Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus.
abstract: OBJECTIVE
  Pleomorphic adenoma is the most common benign tumor of the major salivary glands, especially of the parotid gland. It is much less common in the minor salivary glands of the oral cavity, and it rarely occurs in others sites in the head and neck. Even if virus involvement in salivary glands tumor has been many times discuted, the etiology of this tumor keeps being unknown. As compared to other nasal tumors, we tried to prove if Epstein-Barr virus (EBV) could be involved in the development of pleomorphic adenoma in this particular nasal localization.
  
  
  METHODS
  Three cases of pleomorphic adenomas of the nasal septum (two women and a man in age of 23-59 years) were retrospectively studied. All had positive rate of EBV-related blood antibodies. All the patients had undergone endoscopic surgery to remove the complete tumor. We used hybridation technique in the search for EBV-DNA in the three tumors.
  
  
  CONCLUSIONS
  We had positive EBV-DNA detection in the tumor in one case, which seemed to prove relationship between pleomorphic adenoma and this virus. The literature concerning the subject is reviewed in order to explain EBV involvement in the development of such tumors in this particular localization.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, Faculté Necker Enfants Malades, Université Paris V, 20 Rue Leblanc, Paris, France. david.malinvaud@hop.egp.ap-hop-paris.fr
authors.forename: David
authors.initials: D
authors.lastname: Malinvaud
authors.forename: Vincent
authors.initials: V
authors.lastname: Couloigner
authors.forename: Cecile
authors.initials: C
authors.lastname: Badoual
authors.forename: Philippe
authors.initials: P
authors.lastname: Halimi
authors.forename: Pierre
authors.initials: P
authors.lastname: Bonfils
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology / Q000601:surgery / Q000821:virology*; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000032:analysis*; D004724:Endoscopy; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000601:surgery / Q000821:virology*; D014057:Tomography, X-Ray Computed
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral