Improvement of walking disturbance by beraprost sodium in rat femoral artery occlusion models.
In rats receiving bilateral femoral arteries ligation (day 0), repeated oral administration of the prostacyclin derivative beraprost sodium (50 microg/kg, b.i.d.) from day 1 to day 5 resulted in a significant prolongation in walking time in rotarod walking exercise performed on day 5. Similarly, results were obtained in rats with bilateral femoral arterial thrombosis induced by application of FeCl(3)/HCl. In the ligation model, a significant increase was observed in femoral/carotid arterial blood pressure ratio even on day 2. These results indicated that beraprost sodium improves blood flow and walking disturbances associated with arterial occlusion in rats.
Miyamoto
Mitsuko
M
Pharmaceutical Laboratories, Toray Industries, Inc., 1111 Tebiro, Kamakura, Kanagawa, 248-8555, Japan. Mitsuko_Miyamoto@nts.toray.co.jp
Tayama
Toshikazu
T
Yamaguchi
Sin'ichi
S
Kaneko
Masayuki
M
Kurumatani
Hajimu
H
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005263:Femoral Artery; D007383:Intermittent Claudication / Q000188:drug therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D016138:Walking
C048081:beraprost; D011464:Epoprostenol