title: The effect of lidocaine and sufentanil in preventing intraocular pressure increase due to succinylcholine and endotracheal intubation.
abstract: OBJECTIVE
  Succinylcholine administration, laryngoscopy and tracheal intubation are followed by increased intraocular pressure. Various premedications have been advocated for preventing increases in intraocular pressure, especially in patients undergoing surgical repair of open globe due to penetrating eye trauma. Results of studies in this area have been controversial.
  
  
  METHODS
  In this double-blind study, three groups of 70 patients receiving sufentanil, lidocaine and placebo 90 s prior to intubation were evaluated and compared for intraocular pressure changes following succinylcholine administration, laryngoscopy and tracheal intubation.
  
  
  RESULTS
  Mean intraocular pressure measured 2 and 3 min after succinylcholine administration in groups receiving sufentanil and lidocaine was significantly lower than in the placebo group. Mean intraocular pressure changes in the three groups were -1.84, -2.03 and +2.82 mmHg, respectively in minute 2; -4.78, -4.73 and +1.35 mmHg, respectively in minute 5. There was a significant intraocular pressure decrease in the sufentanil and lidocaine groups, compared to the placebo group. The eye surgeons' satisfaction was also significantly higher with the sufentanil and lidocaine groups.
  
  
  CONCLUSIONS
  Previous studies have yielded controversial results as to the effect of sufentanil and lidocaine in preventing intraocular pressure following succinylcholine administration, laryngoscopy and tracheal intubation. The present study affirms the preventive effect of these drugs on intraocular pressure increase.
authors.affiliation: University of Isfahan Medical Science, Faculty of Medicine, Ophthalmology Department, Iran.
authors.forename: H A
authors.initials: HA
authors.lastname: Moeini
authors.forename: H A
authors.initials: HA
authors.lastname: Soltani
authors.forename: A R
authors.initials: AR
authors.lastname: Gholami
authors.forename: H
authors.initials: H
authors.lastname: Masoudpour
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007442:Intubation, Intratracheal / Q000379:methods*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000494:pharmacology; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D013390:Succinylcholine / Q000378:metabolism*; D017409:Sufentanil / Q000494:pharmacology*
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D009467:Neuromuscular Depolarizing Agents; D009020:Morphine; D008012:Lidocaine; D017409:Sufentanil; D013390:Succinylcholine