Discovery and structure-activity relationship studies of a unique class of HIV-1 integrase inhibitors.
HIV-1 integrase (IN) is an essential enzyme for viral replication and a validated target for the development of drugs against AIDS. Currently there are no approved drugs that target IN. However, new IN inhibitors are under clinical investigation. As more IN inhibitors enter human drug trials, there is a growing need for the design of novel lead compounds with diverse structural scaffolds and promising pharmacokinetic properties to counteract the difficulties observed with first-generation IN inhibitors. We have identified a novel class of IN inhibitors through the systematic exploration of structure-activity relationships in a series of linomide analogues. The predicted bound conformation of the most active analogues inside the IN active site also supports the observed structure-activity correlation in this new compound class.
Dayam
Raveendra
R
Department of Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90089, USA.
Sanchez
Tino
T
Neamati
Nouri
N
D001483:Base Sequence; D017931:DNA Primers; D015195:Drug Design; D019427:HIV Integrase / Q000187:drug effects; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D017931:DNA Primers; D019428:HIV Integrase Inhibitors; D019427:HIV Integrase