title: Effect of fish or soybean oil-rich diets on bradykinin, kallikrein, nitric oxide, leptin, corticosterone and macrophages in carrageenan stimulated rats.
abstract: We have previously demonstrated that both n-3 and n-6 polyunsaturated fatty acids (PUFA)-rich diets decrease the acute inflammatory response partially explained by the high corticosterone basal levels. The present study aimed to determine the effect of hyperlipidic diets (PUFA n-3 or n-6) on phagocytosis, hydrogen peroxide (H(2)O(2)) and nitric oxide (NO) release by macrophages, bradykinin (BK) and NO release in the paw inflammatory perfusate and Kallikrein (KK), corticosterone and leptin blood levels. Hyperlipidic diets decreased H(2)O(2) release from macrophages stimulated by carrageenan or phorbol-miristate-acetate (PMA), NO release from macrophage stimulated by carrageenan, BK and NO release in the edema perfusate, KK plasma levels and the increase of serum leptin after carrageenan stimulus. These data show that both fish and soybean oil-rich diets promote similar alterations on inflammatory mediators of carrageenan edema and a causal association with the anti-inflammatory effect of these diets.
authors.affiliation: Physiology Department, Federal University of São Paulo-EPM, Rua Botucatu 862-2 andar, Vila Clementino-CEP, São Paulo 04023-060, Brazil.
authors.forename: Marta
authors.initials: M
authors.lastname: Wohlers
authors.forename: Roberta Araujo Navarro
authors.initials: RA
authors.lastname: Xavier
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
authors.forename: Eliane Beraldi
authors.initials: EB
authors.lastname: Ribeiro
authors.forename: Cláudia Maria Oller
authors.initials: CM
authors.lastname: do Nascimento
authors.forename: Dulce Elena
authors.initials: DE
authors.lastname: Casarini
authors.forename: Vera Lucia Flor
authors.initials: VL
authors.lastname: Silveira
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000096:biosynthesis* / Q000378:metabolism; D002351:Carrageenan / Q000494:pharmacology*; D003345:Corticosterone / Q000378:metabolism*; D005395:Fish Oils / Q000378:metabolism*; D005399:Fishes; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology; D007610:Kallikreins / Q000378:metabolism*; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000378:metabolism*
chemical_list: D005395:Fish Oils; D020738:Leptin; D009569:Nitric Oxide; D013024:Soybean Oil; D002351:Carrageenan; D006861:Hydrogen Peroxide; D007610:Kallikreins; D001920:Bradykinin; D003345:Corticosterone