title: [Hypogonadism may cause insulin resistance in young males].
abstract: OBJECTIVE
  To investigate the relationship between hypogonadism and insulin resistance in young male.
  
  
  METHODS
  Twenty-one hypogonadism young males aged 15 to 30 years were included in the clinical trial group, and 11 healthy young males of similar age and BMI in the control. Height, weight, serum FSH, LH, total testosterone (TT), nuclear type and bone age were measured for all the subjects. Serum glucose and insulin levels were taken through 3 h OGTT at 0, 30, 60, 120 and 180 min. And comparisons were made of the levels of fast glucose and insulin, areas under the curve of glucose and insulin and HOMA insulin resistance indexes (HOMA-IR) between the two groups.
  
  
  RESULTS
  (1) In the hypogonadism group the average value of TT was (0.9 +/- 0.6) nmol/L and 5 cases of Klinefelter syndrome had pubertal development with Tanner stage above P3, while the other 16 had no. (2) No significant differences were found in BMI, age, areas under the glucose and insulin secretory curve in OGTT between the two groups. (3) Three patients were diagnosed as IGT by OGTT in hypogonadism group, whose serum glucose levels at 120 min were 8.6, 7.9 and 8.2 mmol/L respectively. The maximal insulin excretion time was 30 min after glucose loading. No IGT or DM was found in the control group. (4) Significant difference was found in HOMA-IR and fast insulin level between the two groups.
  
  
  CONCLUSIONS
  (1) IGT incidence was higher in the hypogonadism group than in the control. (2) HOMA-IR and fast insulin levels were significantly higher in the hypogonadism group than in the control, which suggests that lower serum testosterone may cause insulin resistance in young male patients.
authors.affiliation: Department of Endocrinology, Peking Union Hospital, China Union Medical University, Beijing 100730, China.
authors.forename: Jiang-feng
authors.initials: JF
authors.lastname: Mao
authors.forename: Xue-yan
authors.initials: XY
authors.lastname: Wu
authors.forename: Nai-shi
authors.initials: NS
authors.lastname: Li
authors.forename: Yi-fan
authors.initials: YF
authors.lastname: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007006:Hypogonadism / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D013739:Testosterone / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone