Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strain.
We developed mathematical modeling tools for mapping 3D infarct geometry from multislice late gadolinium enhancement data, allowing fusion with multislice MR tagging data, in mice with myocardial infarction. Five C57BL/6 mice were imaged at baseline, 1, 7 and 28 days after 60 min occlusion of the left anterior descending coronary artery. The 3D infarct geometry was mapped in material coordinates, and registered with 3D strain, showing permanent dysfunction in infarcted segments, intermediate function in the adjacent zone, and maintained function in the remote zone. 3D mapping of late enhancement and strain allows registration of multiple studies in a consistent framework.
Young
Alistair A
AA
Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. a.young@auckland.ac.nz
French
Brent A
BA
Yang
Zequan
Z
Cowan
Brett R
BR
Gilson
Wesley D
WD
Berr
Stuart S
SS
Kramer
Christopher M
CM
Epstein
Frederick H
FH
D000704:Analysis of Variance; D000818:Animals; D001185:Artificial Intelligence; D003287:Contrast Media / Q000008:administration & dosage*; D023921:Coronary Stenosis / Q000175:diagnosis; D004195:Disease Models, Animal; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006339:Heart Rate; D007089:Image Enhancement; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D008962:Models, Theoretical; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D013318:Stroke Volume; D013997:Time Factors; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
D003287:Contrast Media; D019786:Gadolinium DTPA