Synthesis of 2H-indazoles via Lewis acid promoted cyclization of 2-(phenylazo)benzonitriles.
Lewis-acid promoted "coarctate" cyclization of 10 2-(phenylazo)benzonitrile derivatives furnishes the isoindazole ring system in ca. 65-95% yield. A plausible mechanism for this unusual transformation is proposed.
Shirtcliff
Laura D
LD
Department of Chemistry, University of Oregon, Eugene, Oregon 97403-1253, USA.
Rivers
Jazmin
J
Haley
Michael M
MM