title: Bone mineral density in users of two kinds of once-a-month combined injectable contraceptives.
abstract: OBJECTIVE
  The objective of this descriptive study was to compare bone mineral density (BMD) between users of two kinds of once-a-month combined injectable contraceptives (CICs) and control subjects.
  
  
  METHODS
  This cross-sectional descriptive study included 97 women aged between 20 and 45 years using CICs containing either 25 mg of medroxyprogesterone acetate and 5 mg of estradiol cypionate for 12-82 months or 50 mg of norethindrone enanthate and 5 mg of estradiol valerate for 12-60 months, matched by age (+/-1 year) and body mass index (BMI; kg/m(2)) (+/-1) with users of the TCu 380A intrauterine device as control subjects. BMD was evaluated at the midshaft of the ulna and at the distal section of the radius of the nondominant forearm using double X-ray absorptiometry.
  
  
  RESULTS
  There was no difference in BMD between users of either CIC and nonusers at either section of the forearm studied. There was also no difference in BMD between users of the two CICs at either section of the forearm.
  
  
  CONCLUSIONS
  Women aged between 20 and 45 years, currently using one of these two kinds of CICs, presented BMDs similar to those of control subjects paired by age and BMI.
authors.affiliation: Human Reproduction Unit, Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas, Campinas 13084-971, São Paulo, Brazil. bahamond@caism.unicamp.br
authors.forename: Luis
authors.initials: L
authors.lastname: Bahamondes
authors.forename: Cássia Teatin
authors.initials: CT
authors.lastname: Juliato
authors.forename: Marina
authors.initials: M
authors.lastname: Villarreal
authors.forename: Bruno
authors.initials: B
authors.lastname: Sobreira-Lima
authors.forename: José A
authors.initials: JA
authors.lastname: Simões
authors.forename: Arlete M
authors.initials: AM
authors.lastname: dos Santos Fernandes
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015992:Body Mass Index; D015519:Bone Density; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007267:Injections; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives; D011884:Radius; D014457:Ulna
chemical_list: D003271:Contraceptive Agents, Female; D004958:Estradiol; C007630:estradiol 17 beta-cypionate; D017258:Medroxyprogesterone Acetate; C024319:norethindrone enanthate; D009640:Norethindrone