title: Long-term survival in post-transplant lymphoproliferative disorders with a dose-adjusted ACVBP regimen.
abstract: Post-transplant lymphoproliferative disorders (PTLD) are severe complications after solid organ transplantation with no consensus on best treatment practice. Chemotherapy is a therapeutic option with a high response and a significant relapse rate leading to a low long-term tolerance rate. Currently, most centres use anthracycline-based drug combinations, such as CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone). We assessed the efficacy and safety of a dose-adjusted ACVBP (doxorubicin reduced to 50 mg/m(2), cyclophosphamide adjusted to renal function, vindesine, bleomycin, prednisone) regimen in patients failing to respond to a reduction in immunosuppressive therapy. Favourable responses were observed in 24 (73%) of the 33 treated patients. Fourteen (42%) patients died, mostly from PTLD progression. Actuarial survival was 60% at 5 years and 55% at 10 years. Survival prognostic factors were: number of involved sites (P = 0.007), clinical stage III/IV (P = 0.004), bulky tumour (P < 0.0001), B symptoms (P = 0.03), decreased serum albumin (P = 0.03) and poor performance status (P = 0.06). Both the international and the PTLD prognostic index were predictive for survival (P = 0.001 and P = 0.002, respectively). Overall 128 cycles were given. Grade 3 or 4 neutropenia was recorded after 26 (20%) chemotherapy cycles in 19 (58%) patients. Forty-one (32%) infections were recorded in 26 (79%) patients. This study demonstrated that an individual dose-adjustment of ACVBP regimen was manageable in PTLD patients and favourably impacted on long-term survival.
authors.affiliation: Department of Haematology and Oncology, Hopitaux Universitaires de Strasbourg, Strasbourg, France. cecile.fohrer@chru-strasbourg.fr
authors.forename: Cécile
authors.initials: C
authors.lastname: Fohrer
authors.forename: Sophie
authors.initials: S
authors.lastname: Caillard
authors.forename: Argyro
authors.initials: A
authors.lastname: Koumarianou
authors.forename: Bernard
authors.initials: B
authors.lastname: Ellero
authors.forename: Marie-Lorraine
authors.initials: ML
authors.lastname: Woehl-Jaeglé
authors.forename: Carole
authors.initials: C
authors.lastname: Meyer
authors.forename: Eric
authors.initials: E
authors.lastname: Epailly
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Chenard
authors.forename: Bruno
authors.initials: B
authors.lastname: Lioure
authors.forename: Shanti
authors.initials: S
authors.lastname: Natarajan-Ame
authors.forename: Frédéric
authors.initials: F
authors.lastname: Maloisel
authors.forename: Philippe
authors.initials: P
authors.lastname: Lutun
authors.forename: Romain
authors.initials: R
authors.lastname: Kessler
authors.forename: Bruno
authors.initials: B
authors.lastname: Moulin
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bergerat
authors.forename: Philippe
authors.initials: P
authors.lastname: Wolf
authors.forename: Raoul
authors.initials: R
authors.lastname: Herbrecht
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000209:etiology / Q000401:mortality; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000188:drug therapy* / Q000401:mortality; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D015996:Survival Rate; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage; D014751:Vindesine / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D014751:Vindesine; D011241:Prednisone