Evidence of a genetic basis of Morgagni-Stewart-Morel syndrome. A case report of identical twins.
We report two 71-year-old female monozygotic twins presenting with advanced hyperostosis frontalis interna, obesity, shortness and cognitive impairment. They both have suffered from generalized seizures since their early adulthood. Moreover, the patients showed some additional conditions only occurring in one individual or the other such as migraine, marked recurrent depressive disorder or polyarthrosis. The symptoms common to both twins appear to correspond to the Morgagni-Stewart-Morel syndrome and indicate a genetic basis of this disorder as these features occur in genetically identical patients.
Koller
Michael F
MF
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland. miko1@gmx.ch
Papassotiropoulos
Andreas
A
Henke
Katharina
K
Behrends
Britta
B
Noda
Shigeru
S
Kratzer
Adelgunde
A
Hock
Christoph
C
Hofmann
Marc
M
D000368:Aged; D000369:Aged, 80 and over; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D006957:Hyperostosis Frontalis Interna / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D018433:Twin Studies as Topic; D014430:Twins, Monozygotic