Release of anti-restenosis drugs from poly(ethylene oxide)-poly(DL-lactic-co-glycolic acid) nanoparticles.
Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly(dl-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method. A fast release of drug in PBS (pH 7.4) at 37 degrees C resulting in 100% release within 5 h was observed for both drugs. The rate of drug release was substantially reduced by treating the particles with gelatin or albumin after drug loading, resulting in a linear drug release in time. It was shown that the rate of drug release is related to the amount of protein associated with the nanoparticles. After gelatin treatment of drug-loaded nanoparticles, sustained release of dexamethasone for 17 days and of rapamycin for 50 days could be achieved.
Zweers
Miechel L T
ML
Department of Polymer Chemistry and Biomaterials, Institute for Biomedical Technology, Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands.
Engbers
Gerard H M
GH
Grijpma
Dirk W
DW
Feijen
Jan
J
D023903:Coronary Restenosis / Q000517:prevention & control*; D003907:Dexamethasone / Q000008:administration & dosage* / Q000737:chemistry; D004058:Diffusion; D004337:Drug Carriers; D004852:Epoxy Compounds; D005027:Ethylene Oxide / Q000008:administration & dosage*; D019344:Lactic Acid; D049329:Nanostructures; D011091:Polyesters; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D011506:Proteins / Q000032:analysis; D020123:Sirolimus / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility
D004337:Drug Carriers; D004852:Epoxy Compounds; C402662:PEO-poly(lactide); D011091:Polyesters; D011108:Polymers; D011506:Proteins; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003907:Dexamethasone; D005027:Ethylene Oxide; D020123:Sirolimus