title: Delayed posttraumatic Propionibacterium acnes endophthalmitis in a child.
abstract: A 7-year-old boy presented with granulomatous anterior uveitis after an unrecognized penetrating injury in the same eye 2 months previously. The uveitis was unresponsive to topical corticosteroid therapy, lensectomy with anterior vitrectomy, and administration of intraocular and subconjunctival injections of vancomycin. Pars plana vitrectomy, capsulectomy, and injection of intravitreal vancomycin were eventually performed, leading to complete resolution of the intraocular inflammation. Culture and histopathologic examination of a capsular specimen confirmed sequestered Propionibacterium acnes infection. This case demonstrates that P. acnes may cause delayed endophthalmitis following penetrating trauma and may persist within capsular remnants in the aphakic eye.
authors.affiliation: W K Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor 48105, USA.
authors.forename: Tony H
authors.initials: TH
authors.lastname: Huynh
authors.forename: Mark W
authors.initials: MW
authors.lastname: Johnson
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D065306:Corneal Injuries; D009877:Endophthalmitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D015807:Eye Injuries, Penetrating / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D007267:Injections; D007903:Lens Capsule, Crystalline / Q000601:surgery; D008297:Male; D011425:Propionibacterium acnes / Q000302:isolation & purification*; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D014640:Vancomycin / Q000627:therapeutic use; D014821:Vitrectomy
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin