alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy.
Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized pathologically by inclusions in the brain containing alpha-synuclein, which is phosphorylated at serine 129. alpha-Synuclein is present not only in the brain but also in platelets; platelets have previously been used to study mitochondrial function in PD. We undertook to determine whether alpha-synuclein extracted from platelets of patients with PD and MSA is phosphorylated at serine 129 and could be used as a peripheral marker of these disorders. Immunoblots indicated that platelet alpha-synuclein is not phosphorylated at serine 129 in PD and MSA.
Shults
Clifford W
CW
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0662, USA. cshults@ucsd.edu
Barrett
Jennifer M
JM
Fontaine
Deborah
D
D000328:Adult; D000368:Aged; D000818:Animals; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D015153:Blotting, Western / Q000379:methods; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism*; D012694:Serine / Q000378:metabolism*; D051844:alpha-Synuclein / Q000097:blood*
D029681:Arabidopsis Proteins; D002352:Carrier Proteins; C097202:MBP1 protein, Arabidopsis; D051844:alpha-Synuclein; D012694:Serine