Effects of neuropeptide Y on feeding microstructure: dissociation of appetitive and consummatory actions.
The effects of intracerebroventricular application of Neuropeptide Y (NPY) on licking microstructure for sucrose, saccharin, and water solutions were evaluated. In Experiment 1, NPY increased meal size for three sucrose concentrations (0.03 M, 0.3 M, and 1.0 M) by increasing licking burst number but not size and by extending meals more than four-fold in duration with a slow, sustained rate of ingestion in late phases of the meal. Results are consistent with the interpretation that NPY suppressed inhibitory postingestive feedback. Experiment 2 supported this conclusion. NPY significantly increased the number of meals initiated for water, 0.1% saccharin, and 1.0 M sucrose solutions, but meal size was only increased for 1.0 M sucrose. Therefore, NPY also increased appetitive feeding behaviors, but its consummatory effects were limited to caloric solutions. The results are discussed with regard to their potential to explain current discrepancies in the literature.
Baird
John-Paul
JP
Department of Psychology, Amherst College, Amherst, MA 01002, USA. jpbaird@amherst.edu
Gray
Nora E
NE
Fischer
Shannon G
SG
D000704:Analysis of Variance; D000818:Animals; D019167:Appetite Stimulants / Q000494:pharmacology; D001070:Appetitive Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005518:Food Preferences / Q000187:drug effects*; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012439:Saccharin / Q000008:administration & dosage; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D013649:Taste / Q000187:drug effects / Q000502:physiology*
D019167:Appetite Stimulants; D009478:Neuropeptide Y; D013549:Sweetening Agents; D013395:Sucrose; D012439:Saccharin