title: An overview of recent applications of inductively coupled plasma-mass spectrometry (ICP-MS) in determination of inorganic impurities in drugs and pharmaceuticals.
abstract: The recent applications of inductively coupled plasma-mass spectrometry (ICP-MS) in determination of trace level inorganic impurities in drugs and pharmaceuticals have been reviewed. ICP-MS coupled with LC, GC and CE was used for speciation of heavy metals in pharmaceutical products. The review covers the period from 1995 to 2005 during which the technique was applied not only for determination of metallic impurities but also the assay of various trace elements in pharmaceuticals.
authors.affiliation: Analytical Chemistry Division, Discovery Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India. rnrao55@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Nageswara Rao
authors.forename: M V N Kumar
authors.initials: MV
authors.lastname: Talluri
mesh_terms: D004340:Drug Contamination; D013058:Mass Spectrometry / Q000379:methods*; D008670:Metals / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D014131:Trace Elements
chemical_list: D008670:Metals; D004364:Pharmaceutical Preparations; D014131:Trace Elements