Plasma level of mitochondrial coupling factor 6 increases in patients with type 2 diabetes mellitus.
Coupling factor 6 (CF6) is a novel endogenous inhibitor of prostacyclin. Plasma CF6 and 6-keto-PGF(1a) were measured by radioimmunoassay in 70 consecutively recruited patients with type 2 diabetes and in 56 healthy controls. A significantly increased plasma CF6 level was found in diabetics compared with controls. The CF6 level was inversely correlated with plasma 6-keto-PGF(1a) level and positively correlated with blood glucose and lipids. These results suggest that CF6 might be an obvious marker of impaired endothelium and might contribute to vascular damage in diabetes.
Li
Xiao Lu
XL
Xing
Qi Chong
QC
Dong
Bo
B
Gao
Yan Yan
YY
Xing
Shan Shan
SS
Pang
Yong Zheng
YZ
Jiang
Hong Feng
HF
Tang
Chao Shu
CS
D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D025261:Mitochondrial Proton-Translocating ATPases / Q000097:blood*; D010086:Oxidative Phosphorylation Coupling Factors / Q000097:blood*
D010086:Oxidative Phosphorylation Coupling Factors; C000628217:F(6) ATPase; D025261:Mitochondrial Proton-Translocating ATPases