title: Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma.
abstract: We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.
authors.affiliation: INSERM U711, Biologie des Interactions Neurones and Glie, Université Pierre et Marie Curie, France.
authors.forename: C
authors.initials: C
authors.lastname: Carpentier
authors.forename: F
authors.initials: F
authors.lastname: Laigle-Donadey
authors.forename: Y
authors.initials: Y
authors.lastname: Marie
authors.forename: N
authors.initials: N
authors.lastname: Auger
authors.forename: A
authors.initials: A
authors.lastname: Benouaich-Amiel
authors.forename: J
authors.initials: J
authors.lastname: Lejeune
authors.forename: G
authors.initials: G
authors.lastname: Kaloshi
authors.forename: J-Y
authors.initials: JY
authors.lastname: Delattre
authors.forename: J
authors.initials: J
authors.lastname: Thillet
authors.forename: M
authors.initials: M
authors.lastname: Sanson
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016009:Chi-Square Distribution; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011446:Prospective Studies; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012307:Risk Factors; D016329:Sp1 Transcription Factor / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D012333:RNA, Messenger; D016329:Sp1 Transcription Factor; D066246:ErbB Receptors