title: [Mycotic complications of shunt infection in children with primary hydrocephalus].
abstract: Recently, the incidence of fungal infections in children, including children with shunt-dependent hydrocephalus, has increased. The analysis comprised 8 children treated in the III Clinic of Pediatrics of ICZMP during the period of 12 months (12% of all infectious complications of the shunt system). The clinical picture of fungal infection included symptoms of shunt dysfunction: febrile conditions, vomiting, distress and loss of appetite. The most common pathogens isolated from the cerebro-spinal fluid were fungi from the Candida species. Mean value of pleocytosis in the cerebro-spinal fluid was 812 cell/microl, and mean protein concentration was 311 mg/dl. Treatment consisted of monotherapy with Diflucan, monotherapy with Ancotil or combined treatment with Ancotil and Amphotericine B. The drugs were administered intravenously and intraventricularly after removal of the shunt and application of external drainage. Sterility of cerebro-spinal fluid was obtained in the shortest time with the use of Ancotil. Prophylactic application of antifungal drugs decreases the frequency of infections in children with shunt-dependent hydrocephalus.
authors.affiliation: III Klinika Pediatrii, Instytut Centrum Zdrowia Matki Polki, ul. Rzgowska 281/289, 93-338 Lódź.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kupś
authors.forename: Teresa
authors.initials: T
authors.lastname: Woźniakowska-Gesicka
authors.forename: Wojciech
authors.initials: W
authors.lastname: Grzegorczyk
authors.forename: Bogdana
authors.initials: B
authors.lastname: Borowska-Rybus
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002675:Child, Preschool; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage; D005437:Flucytosine / Q000008:administration & dosage; D006801:Humans; D006849:Hydrocephalus / Q000601:surgery*; D007223:Infant; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects* / Q000379:methods
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine