[Expression of adhesive molecules, angiogenesis markers and protein products of suppressor genes in neoplasms of oral cavity and maxillary sinus].
BACKGROUND
Adhesion molecules, angiogenesis markers and protein products of suppressor genes are potential prognostic indicators in different type of tumours. The purpose of this study was to analyze relations between expression of these markers and clinical as well as histological features of oral cavity and maxillary sinus tumours.


METHODS
Measurements of expression of CD44, TP53, Nm23 oncoproteins and angiogenesis markers were performed. Forty-three patients treated in years 1985-2000 in the Department of Maxillofacial Surgery of the University Hospital in Wroclaw entered our study. Thirty-two of them were treated for oral cavity cancers. Remaining eleven patients were treated for maxillary sinus cancers.


RESULTS
We have shown, there was a positive correlation between the number of the vessels and presence of the nodal metastases; between histological grading and VCAM expression; between CD44 expression and total surface area of the blood vessels. There was also correlation between total surface area of the blood vessels and patients' survival time.
Jeleń-Krzeszewska
Joanna
J
Klinika Chirurgii Szczekowo-Twarzowej Akademii Medycznej we Wrocławiu.
Jeleń
Michał
M
Zalesska-Krecicka
Maria
M
Zatoński
Tomasz
T
Fraczek
Marcin
M
Preś
Krzysztof
K
Krecicki
Tomasz
T
D014408:Biomarkers, Tumor / Q000032:analysis*; D004268:DNA-Binding Proteins / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D008207:Lymphatic Metastasis; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000098:blood supply / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply / Q000737:chemistry* / Q000473:pathology; D054778:NM23 Nucleoside Diphosphate Kinases; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000473:pathology; D009701:Nucleoside-Diphosphate Kinase / Q000032:analysis*; D014157:Transcription Factors / Q000032:analysis
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D018960:Hyaluronan Receptors; D054778:NM23 Nucleoside Diphosphate Kinases; C114495:TP53TG1 protein, human; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase