[Multifactorial aspect of acute side effects of angiotensin converting enzyme inhibitors].
Angiotensin converting enzyme inhibitors are a class of drugs successfully used in the treatment of cardiovascular diseases. Despite their effectiveness, treatment with these drugs is characterized by chronic and acute side effects with variable expression depending on the clinical context. Angioedema occurs in patients with hypertension or heart failure. Anaphylactoid reaction is also reported in hemodialysis patients and severe hypotensive reaction in patients receiving transfused blood products and plasmapheresis. In this paper, we describe the role of kinins and metallopeptidases in the pathophysiology of these acute side effects. We also propose different experimental and clinical evidences which plead for an ecogenetic nature of these rare but life-threatening events.
Moreau
M-E
ME
Faculté de pharmacie, Université de Montréal, Québec, Canada.
Adam
A
A
D000208:Acute Disease; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000818:Animals; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors