[Treatment of thrombophlebitis by the method of the transplantation of the endothelial cells].
The end XX of century was marked by introduction into the clinical practice of the methods of cellular therapy. Intensive studies on its application for treating the whole series of diseases are conducted. Thrombophlebitis is not an exception in spite of the already existing effective surgical and conservative methods of its treatment. On the rabbits we produced experiments on the treatment of thrombophlebitis of "aseptic" and infectious etiology. The results of complex treatment with the use of autologous vascular endothelial cells were studied. The damaged wall of vein under the conditions of the "aseptic" model of thrombophlebitis, with conducting active complex therapy with the start of antibiotics and trombolitic means is completely covered with endothelium, and only to the place where the dust devils were attached to the walls of vein, defects remain. In these places the wall of vein gradually is extended and undergoes scarring, and the intact sections of vein around the defect are hypertrophied and then they undergo dilatation, being adapted thus to the new conditions of functioning. The transplanted endothelial vascular cells not only modify the process of remodulation of the damaged vein and thus they contribute to averting the dilation of its wall and expansion of scar, but also contribute to the retention of the thickness of the wall of vein. Calculations showed that in the case of "aseptic" etiology the processes of thrombogenesis and treating thrombophlebitis continue more rapidly than in the case of the infectious etiology. The comparison of traditional method of the treatment of thrombophlebitis with the complex (with the application of auto of endothelial cells) showed that the latter is more effective.
Sardzhveladze
N M
NM
Kakabadze
Z Sh
ZSh
Tvaladze
M G
MG
D000818:Animals; D017690:Cell Transplantation / Q000379:methods*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000166:cytology* / Q000637:transplantation*; D005500:Follow-Up Studies; D011817:Rabbits; D013924:Thrombophlebitis / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome