title: Production of resveratrol in recombinant microorganisms.
abstract: Resveratrol production in Saccharomyces cerevisiae was compared to that in Escherichia coli. In both systems, 4-coumarate:coenzyme A ligase from tobacco and stilbene synthase from grapes were expressed. When p-coumaric acid was used as the precursor, resveratrol accumulations in the culture medium were observed to be comparable in E. coli (16 mg/liter) and yeast (6 mg/liter).
authors.affiliation: Plant Research International, 6700 AA Wageningen, The Netherlands. Jules.Beekwilder@wur.nl
authors.forename: Jules
authors.initials: J
authors.lastname: Beekwilder
authors.forename: Rianne
authors.initials: R
authors.lastname: Wolswinkel
authors.forename: Harry
authors.initials: H
authors.lastname: Jonker
authors.forename: Robert
authors.initials: R
authors.lastname: Hall
authors.forename: C H Ric
authors.initials: CH
authors.lastname: de Vos
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bovy
mesh_terms: D000217:Acyltransferases / Q000235:genetics / Q000378:metabolism; D001709:Biotechnology / Q000379:methods; D003066:Coenzyme A Ligases / Q000235:genetics / Q000378:metabolism; D003373:Coumaric Acids / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics* / Q000378:metabolism; D011995:Recombination, Genetic; D000077185:Resveratrol; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics* / Q000378:metabolism; D013267:Stilbenes / Q000378:metabolism*; D014026:Nicotiana / Q000201:enzymology / Q000235:genetics; D027843:Vitis / Q000235:genetics / Q000378:metabolism
chemical_list: D003373:Coumaric Acids; D013267:Stilbenes; D000217:Acyltransferases; C022674:stilbene synthase; D003066:Coenzyme A Ligases; C019943:4-coumarate-CoA ligase; D000077185:Resveratrol