Platinum-catalyzed intramolecular asymmetric hydroarylation of unactivated alkenes with indoles.
[reaction: see text] A 1:1 mixture of the platinum bis(phosphine) complex [(S)-4]PtCl2 [(S)-4 = (S)-3,5-t-Bu-4-MeO-MeOBIPHEP] catalyzes the intramolecular asymmetric hydroarylation of 2-(4-pentenyl)indoles in moderate to good yield with up to 90% ee.
Han
Xiaoqing
X
Duke University, P. M. Gross Chemical Laboratory, Durham, North Carolina 27708-0346, USA.
Widenhoefer
Ross A
RA