Non-coding RNA in fly dosage compensation.
Dosage compensation modulates global expression of an X chromosome and is necessary to restore the balance between X-chromosome and autosome expression in both sexes. A central question in the field is how this regulation is directed. Large non-coding RNAs, such as Xist in mammals and roX in flies, have pivotal roles in targeting chromosome-wide modification for dosage compensation. Several recent studies in Drosophila provide new insight into the principles of X-chromosome recognition and the function of non-coding RNA in this process.
Deng
Xinxian
X
Department of Biological Science, Wayne State University, Detroit, MI 48201, USA.
Meller
Victoria H
VH
D000818:Animals; D004303:Dosage Compensation, Genetic; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D014960:X Chromosome; D049951:X Chromosome Inactivation
D029721:Drosophila Proteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D014157:Transcription Factors; C077885:XIST non-coding RNA; C454144:roX1 protein, Drosophila