Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold.
A short synthetic protocol leading to HIV-1 protease inhibitors with a tertiary alcohol based transition-state mimicking unit and different P2 side chains has been developed.
Ekegren
Jenny K
JK
Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.
Gising
Johan
J
Wallberg
Hans
H
Larhed
Mats
M
Samuelsson
Bertil
B
Hallberg
Anders
A
D000438:Alcohols / Q000737:chemistry*; D018360:Crystallography, X-Ray; D017320:HIV Protease Inhibitors / Q000737:chemistry*; D015497:HIV-1 / Q000201:enzymology*
D000438:Alcohols; D017320:HIV Protease Inhibitors