Apicomplexa genes involved in the host cell invasion: the Cpa135 protein family.
The availability of a bulk of genomic data of Apicomplexa parasites is a unique opportunity to identify groups of related proteins that are characteristic of this phylum. The Cpa135 protein of Cryptosporidium parvum is expressed and secreted through the apical complex at the invasive stage of sporozoite. This protein is characterised by an LCCL domain, a common trait of various secreted proteins within Apicomplexa. Using the Cpa135 as a "virtual template", we have identified Cpa135 orthologous genes in four apicomplexan species (Plasmodium falciparum, Theileria parva, Toxoplasma gondii and Eimeria tenella). In addition, the architecture of the deduced proteins shows that the Cpa135-related proteins are a distinct family among the apicomplexan LCCL proteins.
Tosini
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Department of Infectious, Parasitic and Immunomediated Diseases Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, Italy.
Trasarti
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Pozio
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D000818:Animals; D016782:Apicomplexa / Q000235:genetics* / Q000502:physiology; D016785:Cryptosporidium parvum / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D016786:Eimeria tenella / Q000235:genetics / Q000502:physiology; D005091:Exons / Q000235:genetics; D017125:Genes, Protozoan; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D010963:Plasmodium falciparum / Q000235:genetics; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D016797:Theileria parva / Q000235:genetics / Q000502:physiology; D014122:Toxoplasma / Q000235:genetics / Q000502:physiology; D014774:Virulence / Q000235:genetics
C514023:Cpa135 protein, Cryptosporidium parvum; D008562:Membrane Glycoproteins