Clues to VIP function from knockout mice.
We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: (a) airway reactivity and airway inflammation, as indicators of bronchial asthma; (b) mortality from endotoxemia, a model of septic shock; and (c) the pulmonary circulation. VIP KO mice showed: (a) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; (b) a greater susceptibility to death from endotoxemia; and (c) evidence suggestive of pulmonary hypertension.
Hamidi
S A
SA
Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794-8172, USA. sami.i.said@stonybrook.edu
Szema
A M
AM
Lyubsky
S
S
Dickman
K G
KG
Degene
A
A
Mathew
S M
SM
Waschek
J A
JA
Said
S I
SI
D000818:Animals; D001991:Bronchitis / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism; D004198:Disease Susceptibility; D019446:Endotoxemia / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D015996:Survival Rate; D014660:Vasoactive Intestinal Peptide / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*
D008070:Lipopolysaccharides; D016210:Methacholine Chloride; D014660:Vasoactive Intestinal Peptide