title: Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions.
abstract: Pathomorphological studies described pathological heterogeneity in patients with multiple sclerosis (MS). Different effector mechanisms might therefore be responsible for lesion formation in MS. The present report shows that myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in common marmoset monkeys reflects one specific lesional subtype of MS, namely MS pattern II lesions with antibody/complement-mediated damage. MOG-induced EAE in marmoset monkeys will, therefore, provide an ideal model for therapeutic approaches directed against B-cell/antibody/complement in MS.
authors.affiliation: Department of Neuropathology, Georg-August University Göttingen, Göttingen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Merkler
authors.forename: B
authors.initials: B
authors.lastname: Schmelting
authors.forename: B
authors.initials: B
authors.lastname: Czéh
authors.forename: E
authors.initials: E
authors.lastname: Fuchs
authors.forename: C
authors.initials: C
authors.lastname: Stadelmann
authors.forename: W
authors.initials: W
authors.lastname: Brück
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D002144:Callithrix; D003165:Complement System Proteins / Q000276:immunology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology*; D005260:Female; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology*; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D011994:Recombinant Proteins / Q000276:immunology
chemical_list: D001323:Autoantibodies; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D011994:Recombinant Proteins; D003165:Complement System Proteins