Histomorphology of renal dysplasia--an autopsy study.
A retrospective analysis of pediatric autopsies in the past 18 years was done with the aim of studying the histomorphology of renal dysplasia. Renal dysplasia comprised 150 (3.66%) of the 4,099 pediatric autopsies from 20 weeks of gestation to 1 year of life. Primitive ducts with the fibromuscular collar, the sine qua non of renal dysplasia, was seen in all cases. Lobar disorganization and cysts were seen in all cases except for the 7 cases of hypodysplasia. Other elements were seen in varying proportions: cartilage in 33.7%, bone in 1.08%, thickening of basement membrane of the primitive ducts in 64.13%, extramedullary hematopoiesis in 98.9%, nerve twigs in 72.8%, and nodular renal blastema in 2.17% cases. In unilateral multicystic dysplasia/renal agenesis, the contralateral kidney showed abnormalities in 44.45% and 47.37% of cases, respectively.
Kakkar
Nandita
N
Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. nan@glide.net.in
Menon
Santosh
S
Radotra
B D
BD
D001344:Autopsy; D005865:Gestational Age; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities* / Q000196:embryology; D021782:Multicystic Dysplastic Kidney / Q000196:embryology / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies