Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjects.
The correlation between scores on the Barratt Impulsiveness Scale (BIS) and activation measured by functional magnetic resonance imaging in a dorsolateral prefrontal cortical (DLPFC) activating task was examined in 15 MDMA-using subjects and 19 controls. A significant correlation between BIS scores and DLPFC activation was found, supporting a role for the DLPFC in BIS-measured impulsivity.
Valdes
Ignacio H
IH
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund, Houston, TX 77030, USA. ivaldes@hal-pc.org
Steinberg
Joel L
JL
Narayana
Ponnada A
PA
Kramer
Larry A
LA
Dougherty
Donald M
DM
Swann
Alan C
AC
Barratt
Ernest S
ES
Moeller
Frederick Gerard
FG
D000328:Adult; D001921:Brain / Q000378:metabolism*; D006213:Hallucinogens; D006304:Health Status; D006801:Humans; D007175:Impulsive Behavior / Q000453:epidemiology* / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D017397:Prefrontal Cortex / Q000378:metabolism; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000378:metabolism*
D006213:Hallucinogens; D018817:N-Methyl-3,4-methylenedioxyamphetamine