Bacillisporins D and E, new oxyphenalenone dimers from Talaromyces bacillisporus.
The oligophenalenone dimer duclauxin and two new analogues, bacillisporins D and E, were isolated from the fungus TALAROMYCES BACILLISPORUS in addition to the previously reported bacillisporins A, B and C. Structures were established by spectroscopic studies. Duclauxin and bacillisporins A, B, C and E were evaluated for cytotoxicity against three human cancer cell lines. Bacillisporin A was strongly active against MCF-7 and NCI-H460 and moderately active against SF-268 while bacillisporins B, C and duclauxin were moderately active against all three cell lines.
Dethoup
Tida
T
Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand.
Manoch
Leka
L
Kijjoa
Anake
A
Nascimento
Maria São
MS
Puaparoj
Prapawadee
P
Silva
Artur M
AM
Eaton
Graham
G
Herz
Werner
W
D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D019281:Dimerization; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D043803:Phenalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D032901:Talaromyces / Q000737:chemistry*
D002867:Chromones; D003603:Cytotoxins; D043803:Phenalenes; C515798:bacillisporin D; C515799:bacillisporin E; C007564:duclauxin