Immune dysregulation in atopic dermatitis.
Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in affected individuals. It is characterized by dysregulated immune responses that consist of an increased systemic Th2 response and a combination of Th2 and Th1 responses in the skin lesions. In this article, we review factors that contribute to these abnormal responses, including key effector cells of the immune system, chemokines, defective skin barrier, genetic predisposition, and environmental triggers. Understanding these pathomechanisms may improve our current therapies for atopic dermatitis.
Ong
Peck Y
PY
National Jewish Medical and Research Center,Department of Pediatrics, Room K926i,1400 Jackson Street, Denver, Colorado 80206, USA.
Leung
Donald Y M
DY
D000485:Allergens / Q000276:immunology; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens