title: [Bilateral optic neuropathy and non-Hodkin's lymphoma].
abstract: While ocular lesion is commonly known in lymphoma, optic neuropathy is very rare : 1,3% of lymphomas affecting the central nervous systems.
  
  
  METHODS
  Authors report the case of a 75 year old patient treated in the haematology department for 8 years, for a large cell B phenotype stage IV lymphoma for which he received 7 chemotherapy courses (CHOP protocol). After a 4 year remission period, he presented a relapse with a rapid progressive bilateral impairment of visual acuity observed for a week before his admission. The ophthalmologic exam revealed no light perception and no afferent reflex on the right eye. There was light perception and weak afferent reflex on the left eye. The anterior segment was normal on both eyes and fundus examination revealed a bilateral stage I papillar oedema. The general exam showed a right facial palsy and an impairment of general condition. The orbital CT scan revealed a significant thickening of both optic nerves caused by lymphomatous infiltration. A chemotherapy with highly dosed IV and intrathecal methotrexate was performed.
  
  
  CONCLUSIONS
  the optic neuropathy is usually associated with a generalized lymphoma with central nervous system involvement, but sometimes can precede the systemic spread of the disease. Apart from infiltration, the optic nerve can be compressed by an intracranial or orbital tumor. The optic neuropathy can also be caused by lymphomatous leptomeningitis.
authors.affiliation: Service d'Ophtalmologie Pédiatrique, Hôpital 20 Août - Casablanca - Maroc. asmaaelkettani@yahoo.fr
authors.forename: A
authors.initials: A
authors.lastname: El Kettani
authors.forename: H
authors.initials: H
authors.lastname: Lamari
authors.forename: D
authors.initials: D
authors.lastname: Lahbil
authors.forename: L
authors.initials: L
authors.lastname: Rais
authors.forename: K
authors.initials: K
authors.lastname: Zaghloul
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D006801:Humans; D007278:Injections, Spinal; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D019574:Optic Nerve Neoplasms / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate