A chromosomal event resulting in possession and expression of multiple HLA-B and Cw genes in a renal patient.
Routine HLA typing of a renal patient for purposes of registration for transplantation revealed an unusual human leucocyte antigen (HLA)-B and Cw genotype, with three specificities detected. Results were confirmed in a second sample, and in a second laboratory. The possibility of these results reflecting a chimaeric state was rejected following short tandem repeat (STR) analysis. Although cytogenetic analysis has failed to detect a chromosomal abnormality, these findings support the view that the aberrant expression of HLA in this patient resulted from an unequal crossover event, occurring during meiosis in a previous generation.
Poole
K
K
Transplant Immunology Laboratory, St James's University Hospital, Beckett Street, Leeds, West Yorkshire, UK. katherine.poole@leedsth.nhs.uk
Montague
B
B
Roberts
R
R
Stoves
J
J
Bendukidze
N
N
Clark
B
B
D046528:Chimerism; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008540:Meiosis; D008875:Middle Aged; D020080:Tandem Repeat Sequences / Q000235:genetics
D015235:HLA-B Antigens; D015236:HLA-C Antigens