Association of serum C-reactive protein and LDL:HDL with myocardial infarction.
OBJECTIVE
To identify frequency of the following markers of atherosclerosis risk: high C-Reactive Protein (CRP) and ratio between serum levels of low density lipoprotein (LDL) and high density lipoprotein (HDL) and to determine the association of high serum CRP levels and LDL:HDL in the patients presenting at NICVD with first myocardial infarction.


METHODS
This case control study was conducted at National Institute for Cardiovascular Disease (NICVD), in Karachi, comprising of 50 male patients of acute myocardial infarction (without any other co-morbidity) and 50 matching controls.


RESULTS
In this study, CRP levels were significantly high (p = 0.003) and serum HDL levels significantly low (p = 0.006) in patients as compared to controls. Serum LDL levels and the ratio of LDL and HDL were not significantly different among the two groups.


CONCLUSIONS
High serum CRP levels rather than high LDL:HDL are associated with myocardial infarction in the patients presenting at NICVD with first myocardial infarction.
Kulsoom
Bibi
B
Department of Biochemistry, Ziauddin Medical University and Hospital, Karachi.
Nazrul
S Hasnain
SH
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis*; D010154:Pakistan
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002097:C-Reactive Protein