Noisy silencing of chromatin.
Chromatin-based repression is a major mechanism for epigenetically heritable variation. Work in the July 21 issue of Molecular Cell quantitatively examines transcriptional silencing in individual yeast cells, demonstrating locus-specific effects and finding that different silencing mutants exhibit qualitatively distinct single-cell defects.
Rando
Oliver J
OJ
Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138.
Paulsson
Johan
J
D002843:Chromatin / Q000235:genetics*; D020868:Gene Silencing; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic
D002843:Chromatin