[Evaluation of effectiveness of radiation therapy for regional control in supraglottic larynx cancer].
The supraglottic cancer is characterised by high incidence of regional metastasis significantly worsening the prognosis. Working out of an adequate regional control represents the one of the important problems. The aim of the study was the evaluation of pre-operative radiation therapy in 331 patients with N-negative supraglottic cancer. Three groups of patients were analyzed: I-radiation therapy/laryngectomy, II-laryngectomy/radiation therapy, III-only laryngectomy. It was found that the main prognostic factors of regional metastasis are: extension, differentiation, ulceration and growth pattern of tumor. The pre-operative radiation therapy is reasonable for effective regional control. The fact that the regional recurrence is developing faster in patients not conducted the radiation therapy at all is also indicating on the above-mentioned. Despite the fact, that the regional control is improving with pre-operative radiation, the overall survival of supraglottic cancer could not be regarded adequate, which requires the further study in terms of evaluation of preventive neck dissections with laryngectomy is this group of patients.
Kalmakhelidze
L D
LD
Mardaleishvili
K M
KM
D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D009367:Neoplasm Staging; D011300:Preoperative Care / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies