Impact of laboratory cross-contamination on molecular epidemiology studies of tuberculosis.
Laboratory cross-contamination by Mycobacterium tuberculosis is known to be responsible for the misdiagnosis of tuberculosis, but its impact on other contexts has not been analyzed. We present the findings of a molecular epidemiology analysis in which the recent transmission events identified by a genotyping reference center were overestimated as a result of unnoticed laboratory cross-contamination in the original diagnostic laboratories.
Martínez
Miguel
M
Complejo Hospitalario Torrecárdenas, Almería, Spain.
García de Viedma
Darío
D
Alonso
María
M
Andrés
Sandra
S
Bouza
Emilio
E
Cabezas
Teresa
T
Cabeza
Isabel
I
Reyes
Armando
A
Sánchez-Yebra
Waldo
W
Rodríguez
Manuel
M
Sánchez
M Isabel
MI
Rogado
M Cruz
MC
Fernández
Rosa
R
Peñafiel
Teresa
T
Martínez
Juan
J
Barroso
Pilar
P
Lucerna
M Angeles
MA
Diez
L Felipe
LF
Gutiérrez
Carmelo
C
D015373:Bacterial Typing Techniques; D003951:Diagnostic Errors; D004866:Equipment Contamination; D006801:Humans; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification*; D014376:Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology*