title: Supplementation of whole persimmon leaf improves lipid profiles and suppresses body weight gain in rats fed high-fat diet.
abstract: The objective of this study was to investigate the hypolipidemic effects of powdered whole persimmon leaf supplement in rats fed high-fat diet. Three groups of male Sprague-Dawley rats during 6 weeks were fed different diet: normal control (NC), high-fat (HF), and high-fat supplemented with powdered whole persimmon leaf (PL; 5%, wt/wt) groups. Body weight and relative weight of interscapular brown adipose tissue were significantly lower in the PL group than in the HF group, while plasma leptin concentration was higher. The supplementation of persimmon leaf significantly lowered the plasma total cholesterol and triglyceride concentrations, whereas elevated the ratio of HDL-C/total-C and improved the atherogenic index. Persimmon leaf supplementation led the hepatic cholesterol and triglyceride values to similar levels to the NC group. Accumulation of hepatic lipid droplets and the epididymal white adipocyte size of PL group were diminished comparing to the HF group. Hepatic HMG-CoA and ACAT activities were significantly higher in the PL group than in other groups. Contents of fecal triglyceride, cholesterol and acidic sterol were significantly higher in the PL group than in the HF group. Accordingly, we suggest that supplementation of the powdered whole persimmon leaf improves plasma and hepatic lipid levels profile partly via the increased fecal lipids in high-fat fed rats. These beneficial effects may be due to the properties of its phenolic compounds (1.15 g/100g) and high fiber (63.48 g/100g) content in the powdered persimmon leaf.
authors.affiliation: Ottogi Research Center, Anyang-si, Kyonngi-do 430-070, Republic of Korea.
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: M K
authors.initials: MK
authors.lastname: Lee
authors.forename: T Y
authors.initials: TY
authors.lastname: Ha
authors.forename: S H
authors.initials: SH
authors.lastname: Bok
authors.forename: H M
authors.initials: HM
authors.lastname: Park
authors.forename: K S
authors.initials: KS
authors.lastname: Jeong
authors.forename: M N
authors.initials: MN
authors.lastname: Woo
authors.forename: G-M
authors.initials: GM
authors.lastname: Do
authors.forename: J-Y
authors.initials: JY
authors.lastname: Yeo
authors.forename: M-S
authors.initials: MS
authors.lastname: Choi
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage*; D029788:Diospyros / Q000737:chemistry*; D004195:Disease Models, Animal; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D000214:Acyl Coenzyme A; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D010936:Plant Extracts; D014280:Triglycerides; C030104:lipoprotein cholesterol; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D002784:Cholesterol; D002785:Sterol O-Acyltransferase