title: Changes in PACAP levels in the central nervous system after ovariectomy and castration.
abstract: The aim of the present article was to investigate the influence of gonadectomy on pituitary adenylate cyclase-activating polypeptide (PACAP) levels in different brain areas. In males, there seems to be an inverse relationship between gonadotropins and PACAP in the brain in the acute phase of castration: PACAP levels decreased in almost all brain areas examined within the first week after castration. In females, such pattern was observed in the hypothalamus, brain stem, and temporal cortex. In the pituitary, levels decreased only on the first day after ovariectomy, and later, as in the thalamus, increases were observed. Although the pattern of change showed gender differences, our results provide further evidence that levels of gonadotropins and possibly gonadotropin-releasing hormone influence PACAP levels and that PACAP is involved in the regulation of gonadal functions.
authors.affiliation: Department of Anatomy, University of Pécs, 7624 Pécs, Szigeti u 12. Hungary.
authors.forename: Jozsef
authors.initials: J
authors.lastname: Nemeth
authors.forename: Andrea
authors.initials: A
authors.lastname: Tamas
authors.forename: Rita
authors.initials: R
authors.lastname: Jozsa
authors.forename: Judit E
authors.initials: JE
authors.lastname: Horvath
authors.forename: Balazs
authors.initials: B
authors.lastname: Jakab
authors.forename: Istvan
authors.initials: I
authors.lastname: Lengvari
authors.forename: Akira
authors.initials: A
authors.lastname: Arimura
authors.forename: Andrea
authors.initials: A
authors.lastname: Lubics
authors.forename: Dora
authors.initials: D
authors.lastname: Reglódi
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D005260:Female; D008297:Male; D010052:Ovariectomy; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D051219:Pituitary Adenylate Cyclase-Activating Polypeptide