Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers.
Olsen
Christian A
CA
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2100 Copenhagen, Denmark.
Mellor
Ian R
IR
Wellendorph
Petrine
P
Usherwood
Peter N R
PN
Witt
Matthias
M
Franzyk
Henrik
H
Jaroszewski
Jerzy W
JW
D006801:Humans; D015640:Ion Channel Gating; D018733:Nicotinic Antagonists / Q000737:chemistry* / Q000633:toxicity*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D011073:Polyamines / Q000737:chemistry* / Q000633:toxicity*; D011978:Receptors, Nicotinic / Q000187:drug effects*; D014862:Wasp Venoms / Q000737:chemistry*
D018733:Nicotinic Antagonists; D011073:Polyamines; D011978:Receptors, Nicotinic; D014862:Wasp Venoms; C028544:cyclohexylalanine; D010649:Phenylalanine; C034092:delta-philanthotoxin