title: Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries.
abstract: An efficient method for preparation of 4,6 or 5,6 disubstituted 3-aminopyridazines was easily carried out starting from easily available 4-bromo-pyridazine-3,6-dione, and using combination of both amination and Pd(0) cross-coupling reactions under microwave irradiation.
authors.affiliation: Laboratoire de Pharmacochimie de la Communication Cellulaire (UMR 7081), Faculté de Pharmacie, Université Louis Pasteur, Illkirch cedex, France. schmitt@pharma.u-strasbg.fr
authors.forename: Martine
authors.initials: M
authors.lastname: Schmitt
authors.forename: João X
authors.initials: JX
authors.lastname: de Araújo-Júnior
authors.forename: Said
authors.initials: S
authors.lastname: Oumouch
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Bourguignon
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D011724:Pyridazines; C513630:aminopyridazine; C062482:pyridazine; D010165:Palladium