title: Parathyroid cancer.
abstract: Parathyroid cancer is a rare endocrine tumor and an uncommon cause of HPT. Advances have been made to identify a promising molecular diagnostic marker for the disease. The use of accurate preoperative imaging modalities would undoubtedly facilitate its management by making an accurate preoperative diagnosis by assessing its invasiveness, and by searching for nodal or distant metastases. The effectiveness of the application of intraoperative PTH assay in the management of this rare condition remains to be seen. Radical surgical treatment offers the best chance of cure, but for patients who have refractory unresectable disease or metastases, the availability of more effective targeted medical therapy may palliate the debilitating symptoms of hypercalcemia, reduce its metabolic complications, and potentially improve survival.
authors.affiliation: Division of Endocrine Surgery, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China.
authors.forename: Brian
authors.initials: B
authors.lastname: Lang
authors.forename: Chung-Yau
authors.initials: CY
authors.lastname: Lo
mesh_terms: D000069449:Cinacalcet; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D007432:Intraoperative Period; D009281:Naphthalenes / Q000627:therapeutic use; D010280:Parathyroid Glands / Q000000981:diagnostic imaging; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D016105:Parathyroidectomy; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D014463:Ultrasonography
chemical_list: D009281:Naphthalenes; D010281:Parathyroid Hormone; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D000069449:Cinacalcet