Structural identification of a new acetildenafil analogue from pre-mixed bulk powder intended as a dietary supplement.
An analogue of acetildenafil was detected in an extract of pre-mixed bulk powder. To our knowledge, the powder was destined to be encapsulated and sold as a dietary supplement. The structure was identified by NMR, HR-ESI-MS, ESI-MSn and FTIR analyses. Owing to the inclusion of a hydroxyl group in acetildenafil, the detected compound was called 'hydroxyacetildenafil'. With increasing use of dietary supplements marketed for penile erectile dysfunction, the detection of analogues of sexual performance enhancers is important and timely.
Hou
Peiling
P
Department of Pharmacy, Faculty of Science, National University of Singapore, Science Drive 4, Singapore 117543.
Zou
Peng
P
Low
Min-Yong
MY
Chan
Eli
E
Koh
Hwee-Ling
HL
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D019587:Dietary Supplements / Q000032:analysis*; D007172:Erectile Dysfunction / Q000628:therapy; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification*; D011687:Purines / Q000737:chemistry / Q000302:isolation & purification; D000068677:Sildenafil Citrate; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013450:Sulfones / Q000737:chemistry / Q000302:isolation & purification*
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate