title: Plasma glucose level decreases as collateral effect of fermented papaya preparation use.
abstract: OBJECTIVE
  Fermented Papaya Preparation (FPP) is a natural healthy drug that has been commercially sold in Japan and Philippines. This nutricetive, bio-normalizer product has antioxidant action, inhibitory effect on oxidative DNA damage and tissue injury, being a potent OH scavanger. The wide use of FPP, expecially by elderly people, made us note an unknown collateral effect, i.e., blood sugar level dropping signs especially in the afternoon. The aim of the present work was to scientifically verify the possibility that individuals, who are taking the nutriceutical FPP, might have a decrease of plasma sugar levels.
  
  
  METHODS
  For this purpose, 50 subjects, divided in two groups, were enrolled. The first group was made of 25 patients: 13 females and 12 males affected by type-2 diabetes mellitus under treatment with the oral antidiabetic drug, glybenclamide. The control group included 25 clinically-healthy subjects: 16 females and 9 males, matching in age. All subjects were given 3 grams of FPP daily, during lunch, for two months.
  
  
  RESULTS
  The results of this study confirmed the empirical experience that FPP use can induce a significant decrease in plasma sugar levels in both healthy subjects and type 2 diabetic patients. This hypoglycaemic effect, associated with clinical signs, induced the diabetic patients to reduce the dosage of their antidiabetic oral therapy (in one patient the therapy was really suspended).
  
  
  CONCLUSIONS
  In accordance with these results, the FPP administration is suggested as an adjuvant drug to join the oral antidiabetic therapy in type 2 diabetes meltus.
authors.affiliation: Department of Clinical Science, University "La Sapienza", Rome, Italy. chiara.danese@uniroma1.it
authors.forename: C
authors.initials: C
authors.lastname: Danese
authors.forename: D
authors.initials: D
authors.lastname: Esposito
authors.forename: V
authors.initials: V
authors.lastname: D'Alfonso
authors.forename: M
authors.initials: M
authors.lastname: Cirene
authors.forename: M
authors.initials: M
authors.lastname: Ambrosino
authors.forename: M
authors.initials: M
authors.lastname: Colotto
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis* / Q000187:drug effects*; D029441:Carica; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D005285:Fermentation; D005638:Fruit; D006801:Humans; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D028321:Plant Preparations