[Increased fracture rate in patients with type 2 diabetes mellitus is independent of its bone mineral density].
Several large-scale clinical studies have recently revealed that both type 1 and type 2 diabetic patients are at higher risk for some fractures than those without diabetes. The fracture rate of type 1 diabetic patients has been reported to increase due to decreased bone mineral density. Type 2 diabetic patients also suffer from increased fracture rate, but bone mineral density is almost the same as those without diabetes, or even increase. Thus, the etiologies of fractures seem to be different between type 1 and type 2 diabetic patients. Increased fracture rate in type 2 diabetic patients may be partly explained by poor bone quality as well as the extra-skeletal factors like falling. Further studies are needed to clarify bone quality and the etiology of fractures in type 2 diabetes.
Yamamoto
Masahiro
M
Shimane University Faculty of Medicine, Department of Internal Medicine I.
Yamaguchi
Toru
T
Sugimoto
Toshitsugu
T
D015519:Bone Density; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D050723:Fractures, Bone / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged