[Current diagnostic status, clinical and pathologic manifestation for a Crohn's disease].
OBJECTIVE
To evaluate the contemporary diagnostic and therapeutic status for Crohn's disease (CD), and analyze its clinical and pathologic manifestation.


METHODS
Retrospectively we reviewed 220 hospitalized inflammatory bowel disease (IBD) cases in which 48 were diagnosed as CD. Data of diagnostic and therapeutic details were recorded.


RESULTS
In the past 10 years 44 of the 48 CD cases were diagnosed in recent and 75.0% of the cases were in the onset age range from 17 to 40 years. The most common symptoms were abdominal pain, diarrhea and bloody stool. 16 (33.3%) of the cases were accompanied with extra-intestinal manifestations, 3 (6.3%) with perianal abscess, and 2 (4.2%) with intestinal fistulation. The main findings through colonoscopy were ulceration, obstruction and cobble stone sign, with a diagnostic correspondence of 85.7% (36/42). Non-caseous granulomas were totally identified in 43.2% (19/44) of the histology. Thirty cases were administrated with Sulfasalazine/Mesalazine (SASP/5-ASA) or corticosteroids/immuno-suppressor in which 27 got clinically improved. Thirteen patients underwent surgery.


CONCLUSIONS
The diagnostic incidence of Crohn's disease has been increased in recent years. The combination of endoscopy, radiography and histology is the best way for the diagnosis of CD. Small intestinal endoscopy and capsule endoscopy with repeated histopathology and follow-up are helpful for the diagnosis.
Yang
Xue-song
XS
Department of Gastroenterology, Peking University Third Hospital, Beijing 100083, China. yangxuesong@bjm.edu.cn
Zhang
Lei
L
Shi
Xue-ying
XY
Zhang
Yun-li
YL
Lv
Yu-min
YM
D000328:Adult; D000368:Aged; D003424:Crohn Disease / Q000175:diagnosis* / Q000628:therapy*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies