title: Koebnerizing sclerodermatous graft-versus-host disease caused by donor lymphocyte infusion and interferon-alpha.
abstract: Graft-versus-host disease (GvHD) is a common sequel to allogeneic bone marrow transplants, which may be accompanied by desirable graft-versus-tumour effects. Sclerodermatous GvHD is a rare subtype that is very difficult to treat. We report the first case of sclerodermatous GvHD as part of the Koebner phenomenon. We propose that donor lymphocyte infusion and interferon-alpha were involved in the pathogenesis of this case.
authors.affiliation: Department of Dermatology, King's College Hospital, Denmark Hill, London SE5 9RS, UK. jonathanmlwhite@hotmail.com
authors.forename: J M L
authors.initials: JM
authors.lastname: White
authors.forename: S
authors.initials: S
authors.lastname: Devereux
authors.forename: A
authors.initials: A
authors.lastname: Pagliuca
authors.forename: J R
authors.initials: JR
authors.lastname: Salisbury
authors.forename: A W P
authors.initials: AW
authors.lastname: du Vivier
authors.forename: D
authors.initials: D
authors.lastname: Creamer
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology; D006086:Graft vs Host Disease / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D017710:Lymphocyte Transfusion / Q000009:adverse effects*; D008297:Male; D012594:Scleroderma, Localized / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha