Synthesis and biological evaluation of copper (II) complexes of sterically hindered o-aminophenol derivatives as antimicrobial agents.
Cu(II) complexes with 4,6-di(tert-butyl)-2-aminophenol (I) and 2-anilino-4,6-di(tert-butyl)phenol (II) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, UV-vis, ESR, and conductance measurements. The compounds I and II can coordinate in their singly deprotonated forms and behave as bidentate O,N-coordinated ligands; their CuL(2) complexes are characterized by CuN(2)O(2) coordination modes and square planar geometry. In vitro antimicrobial screening against Gram-positive and Gram-negative bacteria, yeasts, and moulds indicated that the compound I and its Cu(II) complex were more active than Questiomycin B, the compound II, and its Cu(II) complex.
Loginova
Natalia V
NV
Faculty of Chemistry, Belarusian State University, Leningradskaya str. 14, 220050 Minsk, Belarus. loginonv@yahoo.com
Koval'chuk
Tat'yana V
TV
Zheldakova
Rimma A
RA
Osipovich
Nikolai P
NP
Sorokin
Victor L
VL
Polozov
Genrikh I
GI
Ksendzova
Galina A
GA
Glushonok
Gennady K
GK
Chernyavskaya
Anna A
AA
Shadyro
Oleg I
OI
D000627:Aminophenols / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000627:Aminophenols; D000890:Anti-Infective Agents; D009942:Organometallic Compounds; C027667:2-aminophenol; D003300:Copper