title: Azole resistance of Candida glabrata in a case of recurrent fungemia.
abstract: We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.
authors.affiliation: Department of Microbiology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome 00168, Italy.
authors.forename: Brunella
authors.initials: B
authors.lastname: Posteraro
authors.forename: Mario
authors.initials: M
authors.lastname: Tumbarello
authors.forename: Marilena
authors.initials: M
authors.lastname: La Sorda
authors.forename: Teresa
authors.initials: T
authors.lastname: Spanu
authors.forename: Enrico Maria
authors.initials: EM
authors.lastname: Trecarichi
authors.forename: Flavia
authors.initials: F
authors.lastname: De Bernardis
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Scoppettuolo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sanguinetti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fadda
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology; D001393:Azoles / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology; D041221:Candida glabrata / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005260:Female; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology*; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D006801:Humans; D012008:Recurrence; D014621:Vagina / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D000666:Amphotericin B