title: FXR, a multipurpose nuclear receptor.
abstract: The farnesoid X receptor (FXR) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. In the past six years, remarkable inroads have been made into determining the functional importance of FXR. This receptor has been shown to have crucial roles in controlling bile acid homeostasis, lipoprotein and glucose metabolism, hepatic regeneration, intestinal bacterial growth and the response to hepatotoxins. Thus, the development of FXR agonists might prove useful for the treatment of diabetes, cholesterol gallstones, and hepatic and intestinal toxicity.
authors.affiliation: Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Florence Y
authors.initials: FY
authors.lastname: Lee
authors.forename: Hans
authors.initials: H
authors.lastname: Lee
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Hubbert
authors.forename: Peter A
authors.initials: PA
authors.lastname: Edwards
authors.forename: Yanqiao
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008954:Models, Biological; D020033:Protein Isoforms / Q000235:genetics / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001647:Bile Acids and Salts; D004268:DNA-Binding Proteins; D020033:Protein Isoforms; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated