title: Water may cure patients with Meniere disease.
abstract: OBJECTIVE
  We examined whether sufficient water intake is effective in the long-term control of vertigo and hearing activity in patients with Meniere disease (MD) for whom conventional therapy has proven unsuccessful.
  
  
  METHODS
  The authors conducted a time-series study with historical control.
  
  
  METHODS
  Eighteen patients with MD in group 1 drank 35 mL/kg per day of water for 2 years. Twenty-nine patients with MD treated with the conventional dietary and diuretic therapy for more than 2 years during 1992 to 1999 at the same hospital were enrolled in a historical control of group 2.
  
  
  RESULTS
  Patients in group 1 dramatically relieved vertigo and significantly improved in the hearing of the worst pure-tone average of three frequencies (0.125, 0.25, and 0.5 kHz) (low PTA) during the last 6 months of the study period. In contrast, patients in group 2 became worse in both the four- (0.5, 1, 2, and 4 kHz) frequency PTA and the low PTA, although their vertigo did improve. The number of patients whose hearing were improved, unchanged, and worse were 4, 12, and 2 in group 1 and 2, 11, and 16 in group 2, respectively.
  
  
  CONCLUSIONS
  Deliberate modulation of the intake of water may be the simplest and most cost-effective medical treatment for patients with MD. Larger studies will be needed to confirm these results in a larger patient cohort.
authors.affiliation: Department of Otorhinolaryngology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. naganuma@kitasato-u.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Naganuma
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Kawahara
authors.forename: Koji
authors.initials: K
authors.lastname: Tokumasu
authors.forename: Makito
authors.initials: M
authors.lastname: Okamoto
mesh_terms: D004326:Drinking; D005260:Female; D006311:Hearing Disorders / Q000628:therapy; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000628:therapy*; D008875:Middle Aged; D014667:Vasopressins / Q000097:blood; D014717:Vertigo / Q000628:therapy
chemical_list: D014667:Vasopressins