[Effect of perindopril on indices of cardiac function and quality of life in patients with arterial hypertension in regard to age].
At present in the treatment of arterial hypertension the role of angiotensine converting enzyme inhibitors is significant. From this group the most special attention was attracted to peridopril-esbumin. High efficiency of this preparation has been corroborated by numerous controlled, multicentral investigations. Study of the effect of dosage and peculiarities of peridopril appears to be the most important taking into account age factor that has been insufficiently studied. The goal of our investigation was to study effect of 4 mg and 8 mg of peridopril on functional indices of the heart of patients with hypertonic disease and their psychoemotional sphere in the aspect of age. Total of 78 patients with hypertension and without clinical manifestations of cardiac insufficiency, diabetes mellitus and having had myocardial infarction were examined. According to the age patients were divided into two groups: <65 and >65. The investigations lasted for 12 months. Besides ECG investigations, patients were subjected to echoscopic and doplerographic investigations. For the estimation of life quality a questionnaire of evaluation of general health state (SF-36 Health Status Surveu) containing 11 questions was used. It was shown that peridopril has the different action among patients of different age groups. In older patients (>65 years) it increases indices of physical activity, while in younger patients it has a beneficial effect on the emotional parameters.
Sadunishvili
M Z
MZ
Megreladze
I I
II
Pagava
Z T
ZT
Dzhanaridze
L U
LU
Mamaladze
G T
GT
D000367:Age Factors; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015150:Echocardiography, Doppler; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D020913:Perindopril / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D020913:Perindopril