[Effect of compound glycyrrhizin on peripheral T-lymphocyte subset in AIDS patients].
OBJECTIVE
To probe the effect and mechanism of Compound Glycyrrhizin in treating AIDS.


METHODS
Forty AIDS patients were randomly divided into a treatment group and a control group, both treated with HAART. In addition, the former was given Compound Glycyrrhizin for 6 months, and the CD4+ T count and the expressions of CD8+ and HLA-DR on the surface of peripheral blood lymphocytes (PBL) were studied before and after the treatment.


RESULTS
After 6 months of treatment, the expressions of CD8+ and CD38+ of PBL in the treatment group [(6.6 +/- 2.1)%] were found lower than in the control [(11.4 +/- 3.8)%] (t = 5.043, P < 0.01) and CD4+ T count [(243.6 +/- 91.2) x 10(6)/L vs (170.8 +/- 55.7) x 10(6)/L] rose more significantly (t = 3.045, P < 0.01).


CONCLUSIONS
Compound Glycyrrhizin can lower the expression of active T-lymphocyte subset, inhibit HIV and help immune reconstitution.
Yao
Wen-hu
WH
Department of Infections, the Second Hospital of Nanjing Affiliated to Southeast University Medical College, Nanjing, Jiangsu 210003, China. ywh1950@sina.com
Zhao
Wei
W
Wu
Yin-wei
YW
Zhao
Hong
H
Wei
Hong-xia
HX
Cheng
Cong
C
Zhu
Ping
P
Chi
Yun
Y
D051997:ADP-ribosyl Cyclase 1 / Q000096:biosynthesis; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D019695:Glycyrrhizic Acid / Q000627:therapeutic use*; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology
D019380:Anti-HIV Agents; D006684:HLA-DR Antigens; D019695:Glycyrrhizic Acid; D051997:ADP-ribosyl Cyclase 1