Treatment of primary hyperoxaluria type 1 with sequential liver and kidney transplants from the same living donor.
Alanine-glyoxalate aminotransferase deficiency occurs in patients with primary hyperoxaluria type 1. Increased hepatic oxalate production leads to high urine concentrations of glycolate and oxalate. Calcium oxalate nephrolithiasis and nephrocalcinosis occur, and renal function progressively declines until patients develop end-stage renal disease. Renal transplantation alone is inadequate therapy because the primary enzyme deficiency remains. We report what we believe to be the second-youngest recipient to undergo successful sequential liver and kidney transplantation from a single living-related donor for treatment of primary hyperoxaluria type 1. We also discuss the changes in this patient's serum oxalate levels after transplantation.
Rosenblatt
Gregory S
GS
Department of Surgery, Division of Urology and Renal Transplantation, Oregon Health and Science University, Portland, Oregon 97239-3098, USA. rosenblg@ohsu.edu
Jenkins
Randall D
RD
Barry
John M
JM
D006801:Humans; D006960:Hyperoxaluria, Primary / Q000601:surgery*; D007223:Infant; D016030:Kidney Transplantation; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male