title: [Distribution of HLA-B allele polymorphism of 8962 Han population in Liaoning of China].
abstract: OBJECTIVE
  To investigate the distribution of genetic polymorphism of HLA-B locus in Liaoning Han population.
  
  
  METHODS
  The technique of polymerase chain reaction-sequence specific primers (PCR-SSP) was adopted in genotyping a sample of 8962 unrelated healthy individuals collected from a Chinese Han population in Liaoning area. The allele frequency of HLA-B was calculated and was compared with the results from other population.
  
  
  RESULTS
  Thirty-four HLA-B alleles were detected. The more common HLA-B allele included B*15(14.42%), B*40(14.33%) and B*13(11.99%). The B*82 and B*83 were absent. Forty-nine HLA-B antigens were detected.
  
  
  CONCLUSIONS
  The HLA-B allele polymorphism distribution of Liaoning Han population exhibits its own characteristic and the difference from old south and north Han population in China.
authors.affiliation: Blood Center of Liaoning Province, Shenyang, Liaoning 110044, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005787:Gene Frequency; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D015235:HLA-B Antigens