Allosteric regulation of the conformational dynamics of a cavitand receptor.
[reaction: see text] Inspired by allostery in nature, we synthesized cavitand 1 and investigated regulation of its conformational dynamics. Quantitative 1H NMR studies have revealed that the rate of the conformational isomerization of 1 can be modulated using the external addition of acid. As 1 maintains its vase-like conformation in an acidic environment, ample opportunities for controlling the kinetics of molecular recognition, and thus reactivity, in this and related receptors have arisen.
Yan
Zhiqing
Z
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
Chang
Yuning
Y
Mayo
Dennis
D
Maslak
Veselin
V
Xia
Shijing
S
Badjić
Jovica D
JD