[Soluble receptors of TNF-alpha: association with atherosclerotic vascular affection in systemic lupus erythematosus in males].
OBJECTIVE
To study association between concentration of soluble receptors of TNF-alpha (sTNFa-R1) and atherosclerotic vascular affection in systemic lupus erythematosus (SLE) in men.


METHODS
The examination covered 75 patients (mean age 34.76 +/- 11.8 years), duration of the disease 126 +/- 110 months. Standard cardiovascular risk factors were analysed. SLE activity was estimated by SLEDAI and ECLAM scales, SLICC/ACR index was calculated. Atherosclerotic vascular affection was studied with ultrasonic scanning of the carotid arteries. sTNFa-RI concentration in blood serum was determined with enzyme immunoassay technique in 73 SLE patients and 20 healthy donors.


RESULTS
By sTNFa-R1 concentration, the patients were divided into two groups. Group 1 consisted of patients with sTNFa-R1 < or = 2.87 ng/ml, group 2 > 2.87 ng/ml. Higher concentrations of the receptors were associated with higher mean values of the damage index and proteinuria occurrence, with older age and higher body mass, with signs of vascular atherosclerotic affection (atherosclerotic plaques and intima-media thickness > 0.9 mm.


CONCLUSIONS
Concentration of sTNFa-R1 can be considered as a laboratory marker of atherosclerotic vascular lesions.
Il'ina
A E
AE
Kliukvina
N G
NG
Aleksandrova
E N
EN
Popkova
T V
TV
Novikov
A A
AA
Novikova
D S
DS
Mach
E S
ES
Nasonov
E L
EL
D000293:Adolescent; D000328:Adult; D002340:Carotid Artery Diseases / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D002784:Cholesterol / Q000378:metabolism; D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000502:physiology*; D017539:Tunica Intima / Q000473:pathology
D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol; D000068800:Etanercept