title: Cytotoxic compounds of Schizolaena hystrix from the Madagascar rainforest.
abstract: Bioassay-guided fractionation of a crude ethanol extract from a Madagascar collection of Schizolaena hystrix afforded the two new long-chain compounds, 3 S-acetoxyeicosanoic acid ethyl ester ( 1) and 3 S-acetoxydoeicosanoic acid ( 2), and the known long-chain compound 3 S-acetoxyeicosanoic acid ( 3). In addition, the long-chain alcohol 1-hydroxydodecan-2-one ( 7), as well as the new flavonoid schizolaenone C ( 4) and the two known flavonoids diplacol ( 5) and 3'-prenylnaringenin ( 6) were isolated from a methanol extract of the same plant. Isolation and structure elucidation of the novel compounds and the cytotoxicities of all the isolates are reported.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Murphy
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Andrew
authors.initials: A
authors.lastname: Norris
authors.forename: James S
authors.initials: JS
authors.lastname: Miller
authors.forename: Fidisoa
authors.initials: F
authors.lastname: Ratovoson
authors.forename: Rabodo
authors.initials: R
authors.lastname: Andriantsiferana
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: David G
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D045744:Cell Line, Tumor; D005591:Chemical Fractionation; D004537:Eicosanoic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D007850:Lauric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D008270:Madagascar; D019684:Magnoliopsida / Q000737:chemistry*; D014329:Tropical Climate
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004537:Eicosanoic Acids; D044950:Flavanones; D007850:Lauric Acids