title: Sol-gel derived aluminosilicate coatings on alumina as substrate for osteoblasts.
abstract: Rat bone marrow stromal cell differentiation on aluminosilicate 3Al(2)O(3)-2SiO(2) coatings was investigated. Thin ceramic coatings were prepared on alpha-alumina substrates by the sol-gel process and calcined in order to establish an amorphous aluminosilicate ceramic phase with and without nanosized transitional mullite crystals. In addition, coatings of thermally sprayed aluminosilicate and diphasic gamma-alumina-silica nanosized colloids were prepared. Cell culture testing by rat osteoblasts showed good biocompatibility for aluminosilicates with sustained normal osteoblast functions. Despite mutual disparities in physical and chemical nanostructures, the culture findings suggested fairly similar osteoblast response to all tested coatings. The results suggest that topographical frequency parameters and chemical uniformity are important parameters in determining the best conditions for osteoblasts on sol-gel derived aluminosilicate materials.
authors.affiliation: Institute of Materials Science, Tampere University of Technology, 33101 Tampere, Finland. jarkko.leivo@millidyne.fi
authors.forename: Jarkko
authors.initials: J
authors.lastname: Leivo
authors.forename: Ville
authors.initials: V
authors.lastname: Meretoja
authors.forename: Minnamari
authors.initials: M
authors.lastname: Vippola
authors.forename: Erkki
authors.initials: E
authors.lastname: Levänen
authors.forename: Pekka
authors.initials: P
authors.lastname: Vallittu
authors.forename: Tapio A
authors.initials: TA
authors.lastname: Mäntylä
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry*; D000538:Aluminum Silicates / Q000737:chemistry*; D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D044367:Phase Transition; D051381:Rats; D017207:Rats, Sprague-Dawley; D023822:Tissue Engineering / Q000379:methods
chemical_list: D000538:Aluminum Silicates; D020099:Coated Materials, Biocompatible; D005782:Gels; C049037:aluminosilicate; D000537:Aluminum Oxide