title: Clues to VIP function from knockout mice.
abstract: We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: (a) airway reactivity and airway inflammation, as indicators of bronchial asthma; (b) mortality from endotoxemia, a model of septic shock; and (c) the pulmonary circulation. VIP KO mice showed: (a) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; (b) a greater susceptibility to death from endotoxemia; and (c) evidence suggestive of pulmonary hypertension.
authors.affiliation: Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794-8172, USA. sami.i.said@stonybrook.edu
authors.forename: S A
authors.initials: SA
authors.lastname: Hamidi
authors.forename: A M
authors.initials: AM
authors.lastname: Szema
authors.forename: S
authors.initials: S
authors.lastname: Lyubsky
authors.forename: K G
authors.initials: KG
authors.lastname: Dickman
authors.forename: A
authors.initials: A
authors.lastname: Degene
authors.forename: S M
authors.initials: SM
authors.lastname: Mathew
authors.forename: J A
authors.initials: JA
authors.lastname: Waschek
authors.forename: S I
authors.initials: SI
authors.lastname: Said
mesh_terms: D000818:Animals; D001991:Bronchitis / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism; D004198:Disease Susceptibility; D019446:Endotoxemia / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D015996:Survival Rate; D014660:Vasoactive Intestinal Peptide / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*
chemical_list: D008070:Lipopolysaccharides; D016210:Methacholine Chloride; D014660:Vasoactive Intestinal Peptide