The effects of light and moderate-heavy ethanol exposure on the development of cirrhosis in rats.
Daily, light ethanol consumption has beneficial effects on liver recovery following partial hepatectomy and acute liver failure in rats. The aim of the present study was to determine whether such consumption has a beneficial, deleterious, or no effect on the progression of chronic hepatitis to cirrhosis in rats. Adult, male, Sprague-Dawley rats (n = 66) were gavaged with light (1.0 g/kg/day) or moderate-heavy (3.0 g/kg) ethanol in water daily for the final 8 weeks of a 10-week period of thioacetamide-induced cirrhosis. Control rats were gavaged with water alone. Compared to results in water-fed controls, light-ethanol exposure had beneficial or no effects, while moderate-heavy ethanol exposure had deleterious effects on hepatic inflammation, function, regenerative activity, and fibrosis. The results of this study indicate that daily, light ethanol exposure does not have a deleterious effect on the progression of chronic liver disease to cirrhosis in this animal model.
Zhang
Manna
M
Section of Hepatology, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Gong
Yuewen
Y
Corbin
Ian
I
Minuk
Gerald Y
GY
D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D006521:Hepatitis, Chronic / Q000150:complications* / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000209:etiology* / Q000473:pathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index
D002492:Central Nervous System Depressants; D000431:Ethanol