Suppression of MeIQ-induced SOS response by allylbenzenes from Asiasarum heterotropoides in the Salmonella typhimurium OY1001/1A2 umu test.
Three allylbenzenes from Asiasarum heterotropoides, methyleugenol (1), elemicin (2) and gamma-asaron (3) showed suppressive effects on umu gene expression of the SOS response in the Salmonella typhimurium OY1001/1A2 umu test against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). Gene expression was suppressed 70.0, 75.9 and 81.7% at a concentration of 0.4 mM, respectively. The ID50 values (50% inhibition dose) of these compounds were 0.125, 0.098 and 0.059 mM, respectively. On the other hand, compounds 1-3 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.
Miyazawa
Mitsuo
M
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Higashiosaka-shi, Osaka 577-8502, Japan. miyazawa@apch.kindai.ac.jp
Kohno
Go
G
Okuno
Yoshiharu
Y
Oda
Yoshimitsu
Y
D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D029065:Aristolochiaceae / Q000737:chemistry*; D005054:Eugenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D009152:Mutagenicity Tests; D009153:Mutagens; D011748:Pyrogallol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011804:Quinolines; D013014:SOS Response, Genetics / Q000187:drug effects
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D016587:Antimutagenic Agents; D000970:Antineoplastic Agents; D009153:Mutagens; D011804:Quinolines; C012195:asarone; D011748:Pyrogallol; C005223:methyleugenol; D005054:Eugenol; C002135:elemicin; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline