N-Hydroxy and N-acyloxy peptides: synthesis and chemical modifications.
The preparation of a series of N-hydroxy peptides is described, along with their acylation on the oxygen of the pseudopeptide bond. Nineteen N-acyloxy peptides, first examples of this new class of pseudopeptides, were thus synthesized; they present a range of acyl groups, including N-protected amino acyl groups. Possibilities of elongation for these pseudopeptides were also investigated.
Lawrence
James
J
Grenoble Universités, LEDSS, UMR CNRS/UJF 5616, ICMG, FR-2607, Université Joseph Fourier Grenoble I, BP 53, 38041, Grenoble Cedex 9, France.
Cointeaux
Laure
L
Maire
Pascal
P
Vallée
Yannick
Y
Blandin
Véronique
V
D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation
D010455:Peptides