Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.
The design, synthesis, and unexpected inhibitory activity against S-adenosyl-homocysteine (SAH) hydrolase (SAHase, EC 3.3.1.1) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a Ki value of 5.0 microM against SAHase.
Mosley
Sylvester L
SL
Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Bakke
Brian A
BA
Sadler
Joshua M
JM
Sunkara
Naresh K
NK
Dorgan
Kathleen M
KM
Zhou
Zhaohui Sunny
ZS
Seley-Radtke
Katherine L
KL
D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D007700:Kinetics; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011741:Pyrimidine Nucleosides; D043383:Adenosylhomocysteinase