A convenient synthesis of an anti-Helicobacter pylori agent, dehydrodiconiferyl alcohol.
Potential anti-Helicobacter pylori agent dehydrodiconiferyl alcohol was synthesized in 44% overall yield, starting from vanillin which could be commercially available. Carbon extension of vanillin followed by the Horner-Wadsworth-Emmons reaction, a biomolecular radical coupling reaction and DIBAL-H reduction gave dehydrodiconiferyl alcohol.
Hu
Kun
K
College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea.
Jeong
Jin-Hyun
JH
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001547:Benzaldehydes / Q000737:chemistry; D016480:Helicobacter pylori / Q000187:drug effects; D010084:Oxidation-Reduction; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001547:Benzaldehydes; D010636:Phenols; C080686:dehydrodiconiferyl alcohol; C100058:vanillin