title: Topiramate for migraine prophylaxis.
abstract: About 14% of adults in the UK have migraines. Drugs used in migraine prophylaxis include beta-blockers (e.g. propranolol), 5HT antagonists (e.g. pizotifen), antidepressants (e.g. amitriptyline), antiepileptics (e.g. sodium valproate) and NSAIDs. The antiepileptic topiramate (Topamax-Janssen-Cilag) is licensed for the prophylaxis of migraine headache in patients aged over 16 years. Here we discuss the place of topiramate in migraine prophylaxis.
mesh_terms: D000700:Analgesics / Q000191:economics / Q000627:therapeutic use*; D004311:Double-Blind Method; D016527:Drug Costs; D005632:Fructose / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D006801:Humans; D015201:Meta-Analysis as Topic; D008881:Migraine Disorders / Q000191:economics / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000077236:Topiramate; D005632:Fructose