A mouse strain difference in tumorigenesis induced by biodegradable polymers.
The use of poly-L-lactic acid (PLLA) surgical implants for repair of bone fractures has gained popularity in the past decade. The aim of this study was to evaluate the in vivo effect of PLLA plates on subcutaneous tissue in two mouse strains, BALB/cJ and SJL/J, which have higher and lower tumorigenicity, respectively. Gap-junctional intercellular communication and protein expression of connexin 43 were significantly suppressed, whereas secretion of transforming growth factor-beta1 and expression of extracellular matrix, insulin-like growth factor binding protein 3, and cysteine-rich intestinal protein 2 were significantly increased in PLLA-implanted BALB/cJ mice when compared with BALB/cJ controls. Finally, tumors were formed after implantation of cultured cells from the more-tumorigenic BALB/cJ, but not SJL/J, mice into nude mice.
Ahmed
Saifuddin
S
Division of Medical Devices, National Institute of Health Sciences, 1-18-1 Kamiyoga, Tokyo 158-8501, Japan.
Tsuchiya
Toshie
T
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D018031:Connexin 43 / Q000737:chemistry; D005260:Female; D017629:Gap Junctions; D006016:Glycolates / Q000737:chemistry; D019344:Lactic Acid; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D020411:Oligonucleotide Array Sequence Analysis; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D013045:Species Specificity; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
D001672:Biocompatible Materials; D018031:Connexin 43; D006016:Glycolates; D011108:Polymers; D053773:Transforming Growth Factor beta1; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid