title: Clinical, pathological and toxicological findings of a iatrogenic selenium toxicosis case in feeder pigs.
abstract: Histopathological and toxicological analyses confirmed a clinical diagnosis of selenium (Se) intoxication in pigs from a farm in Spain. After an initial episode of diarrhoea, animals presented both dermatological and neurological signs; the most obvious sign was a marked hind limb paresis. Cutaneous lesions consisted on diffuse alopecia, multifocal skin necrosis and coronary band necrosis of the hooves. Central nervous system lesions involved the cervical and lumbar intumescences of the spinal cord and consisted of a severe, bilateral symmetrical poliomyelomalacia of the ventral horns; pons and medulla oblongata also presented lesions of polioencephalomalacia. Analyses of feed and sera from clinically affected pigs revealed a marked increase in Se concentration. Clinical investigations indicated that a failure in Se dosage in feed was the cause of the toxicosis.
authors.affiliation: Unité Pédagogique d'Histologie et Anatomie Pathologique, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Casteignau
authors.forename: A
authors.initials: A
authors.lastname: Fontán
authors.forename: A
authors.initials: A
authors.lastname: Morillo
authors.forename: J A
authors.initials: JA
authors.lastname: Oliveros
authors.forename: J
authors.initials: J
authors.lastname: Segalés
mesh_terms: D000505:Alopecia / Q000139:chemically induced / Q000662:veterinary; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D005506:Food Contamination / Q000032:analysis*; D006724:Hoof and Claw / Q000473:pathology; D007794:Lameness, Animal / Q000139:chemically induced / Q000473:pathology; D012643:Selenium / Q000506:poisoning*; D013116:Spinal Cord / Q000473:pathology; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D012643:Selenium