Vaccine clinical trials--a statistical primer.
We discuss some of the key statistical issues that arise in all stages of vaccine development and, where necessary, contrast drug and vaccine clinical trials.
Mehrotra
D V
DV
Merck Research Laboratories, North Wales, PA 19454, USA. devan_mehrotra@merck.com
D000818:Animals; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D015233:Models, Statistical; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000706:statistics & numerical data*; D014612:Vaccines / Q000009:adverse effects / Q000138:chemical synthesis / Q000276:immunology / Q000627:therapeutic use*
D014612:Vaccines