title: Mini-incision for strictly retroperitoneal nephrectomy in living kidney donation vs flank incision.
abstract: BACKGROUND
  Mini-incision donor nephrectomies (MIDNs) were established during the last decade, as an alternative to traditional open donor nephrectomy (ODN) via flank incision. In this study, we investigated intra-operative and post-operative data on outcome following MIDN in comparison with ODN data.
  
  
  METHODS
  Data of 70 living kidney donations, performed at the University of Regensburg Medical Center since 1996, were evaluated. Donor operation was performed as either strictly retroperitoneal MIDN (n = 34) or as traditional ODN (n = 36) via flank incision. Total operation time, warm ischaemia time (WIT), perioperative pain-medication usage and creatinine levels as well as length of hospital stay, return to complete enteral nutrition and regular digestion were evaluated retrospectively.
  
  
  RESULTS
  Total operation times were similar in MIDN, n = 34 (132 +/- 26 min) and in ODN, n = 36 (140 +/- 37 min) (P = 0.424). WIT was also similar in both: MIDN (0.9 +/- 0.4 min) and ODN (0.9 +/- 0.4 min) (P = 0.568). The requirement for post-operative opioids in morphine equivalent doses was significantly lower in MIDN (8.4 +/- 16 mg) compared with ODN (44 +/- 57 mg) (P = 0.001). Additional application of non-opioids (metamizole) (MIDN: 4.8 +/- 6.3 g, ODN: 3.4 +/- 3.9 g) and non-steroidal antirheumatic (NSAR) (diclofenac) (MIDN: 322 +/- 361 mg, ODN: 247 +/- 474 mg) revealed no significant differences between the groups. The hospital stay was 4.9 +/- 1.4 days in MIDN which was significantly shorter than that in ODN (9.3 +/- 3.3 days) (P = 0.001). Patients achieved fully independent mobility earlier in MIDN than in ODN (P = 0.934). Start of enteral nutrition with fluids was significantly quicker in MIDN (1.9 +/- 7 h) compared with ODN (12 +/- 13 h) (P = 0.05). Full enteral nutrition was accomplished significantly earlier in MIDN (1.6 +/- 0.8 days) (P = 0.023). Return to normal digestion revealed no significant differences between groups. Serum creatinine levels of all kidney donors were in the normal range (66 +/- 18 micromol/l) one day before nephrectomy, increased on day 1 after surgery (119 micromol/l +/- 31 micromol/l) and were stable on day 3 (115 micromol/l +/- 30 micromol/l) without significant differences.
  
  
  CONCLUSIONS
  Strictly, retroperitoneal MIDN in living kidney donation is a fast and safe method for the procurement of a living donor graft, giving the patient a significantly shorter period of recovery, and thus is an attractive and recommendable alternative to traditional ODN procedures.
authors.affiliation: University of Regensburg Medical Center, Department of Surgery, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. andreas.schnitzbauer@klinik.uni-regensburg.de
authors.forename: A A
authors.initials: AA
authors.lastname: Schnitzbauer
authors.forename: M
authors.initials: M
authors.lastname: Loss
authors.forename: M
authors.initials: M
authors.lastname: Hornung
authors.forename: G
authors.initials: G
authors.lastname: Glockzin
authors.forename: L
authors.initials: L
authors.lastname: Mantouvalou
authors.forename: B
authors.initials: B
authors.lastname: Krüger
authors.forename: B K
authors.initials: BK
authors.lastname: Krämer
authors.forename: H J
authors.initials: HJ
authors.lastname: Schlitt
authors.forename: A
authors.initials: A
authors.lastname: Obed
mesh_terms: D000328:Adult; D000698:Analgesia / Q000379:methods; D003401:Creatine / Q000097:blood; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D007902:Length of Stay; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D008953:Models, Anatomic; D009392:Nephrectomy / Q000379:methods*; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications; D015203:Reproducibility of Results; D012187:Retroperitoneal Space / Q000601:surgery*
chemical_list: D003401:Creatine