Low-grade systemic inflammation and the risk of type 2 diabetes in obese children and adolescents.
BACKGROUND
There is growing evidence that low-grade systemic inflammation is closely involved in the pathogenesis of type 2 diabetes.


OBJECTIVE
The aim of this study was to investigate the relationship between serum inflammatory markers and selected parameters known as risk factors of type 2 diabetes in obese children and adolescents.


METHODS
Fasting levels of C-reactive protein (CRP), fibrinogen (FB) interleukin-6 (IL-6), interleukin 1-beta (IL-1beta), glucose, insulin, total, HDL and LDL cholesterol, triglycerides, white blood cell count (WBC) and fasting glucose to insulin ratio (FGIR) were measured in 281 obese children and adolescents. Pearson's correlation was used for assessing the relationship between inflammatory markers and selected clinical parameters.


RESULTS
Inflammatory markers correlated significantly with insulin resistance indices, HbA1c, lipid profile, hypertension, positive family history of type 2 diabetes, low physical fitness, and mixed high-fat and high-carbohydrate diet.


CONCLUSIONS
Serum inflammatory markers were significantly correlated with most factors implicated in the development of type 2 diabetes. These data provide additional support for previously reported in adults relationship between subclinical inflammation and the risk of type 2 diabetes.
Syrenicz
Anhelli
A
Department of Endocrinology, Arterial Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland. anhelli@asymed.ifg.pl
Garanty-Bogacka
Barbara
B
Syrenicz
Małgorzata
M
Gebala
Aneta
A
Walczak
Mieczysław
M
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000276:immunology* / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000453:epidemiology* / Q000378:metabolism; D007328:Insulin / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D009765:Obesity / Q000453:epidemiology* / Q000276:immunology* / Q000378:metabolism; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D053583:Interleukin-1beta; D015850:Interleukin-6; D014280:Triglycerides; D005340:Fibrinogen; D002097:C-Reactive Protein