Suppression of hepcidin during anemia requires erythropoietic activity.
Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the diet and the mobilization of iron from stores. Previous studies indicated that hepcidin is suppressed during anemia, a response that would appropriately increase the absorption of iron and its release from stores. Indeed, in the mouse model, hepcidin-1 was suppressed after phlebotomy or erythropoietin administration but the suppression was reversed by inhibitors of erythropoiesis. The suppression of hepcidin necessary to match iron supply to erythropoietic demand thus requires increased erythropoiesis and is not directly mediated by anemia, tissue hypoxia, or erythropoietin.
Pak
Mihwa
M
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California (UCLA), Los Angeles, USA.
Lopez
Miguel A
MA
Gabayan
Victroia
V
Ganz
Tomas
T
Rivera
Seth
S
D000740:Anemia / Q000097:blood*; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000097:blood; D005260:Female; D064451:Hepcidins; D000860:Hypoxia / Q000097:blood; D007501:Iron / Q000097:blood*; D019266:Iron, Dietary / Q000378:metabolism; D008297:Male; D051379:Mice
D023181:Antimicrobial Cationic Peptides; C579599:Hamp protein, mouse; D064451:Hepcidins; D019266:Iron, Dietary; D004921:Erythropoietin; D007501:Iron