title: Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model.
abstract: Some have claimed that triclabendazole, a safe and efficacious drug for the treatment of fascioliasis, also exhibits antischistosomal properties, but results are conflicting. We assessed the effect of triclabendazole and its two main metabolites against two different strains of Schistosoma mansoni harbored in mice. Low worm burden reductions (18.6-35.9%) were observed in mice infected with an Egyptian strain of S. mansoni and treated with a single dose of 120 mg/kg 3 days before infection or single/double doses of 120-200 mg/kg 7 weeks after infection. Triclabendazole failed to significantly reduce hepatic and intestinal tissue egg loads, and eggs of all developmental stages were observed. Administration of 400 mg/kg of either triclabendazole, triclabendazole sulphone, or triclabendazole sulfphoxide to mice infected with a Liberian strain of S. mansoni resulted in worm burden reductions < 10%. In comparison, high worm burden reductions (82-100%) were observed in S. mansoni-infected mice treated with single oral doses of 400, 500, or 500 mg/kg twice a day praziquantel, regardless of the S. mansoni strain. We conclude that triclabendazole and its main metabolites display weak and inconsistent schistosomicidal activities.
authors.affiliation: Swiss Tropical Institute, Basel, Switzerland.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keiser
authors.forename: Nadia Abou
authors.initials: NA
authors.lastname: El Ela
authors.forename: Engy
authors.initials: E
authors.lastname: El Komy
authors.forename: Naglaa
authors.initials: N
authors.lastname: El Lakkany
authors.forename: Tarek
authors.initials: T
authors.lastname: Diab
authors.forename: Jacques
authors.initials: J
authors.lastname: Chollet
authors.forename: Jürg
authors.initials: J
authors.lastname: Utzinger
authors.forename: Rashida
authors.initials: R
authors.lastname: Barakat
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D004195:Disease Models, Animal; D005243:Feces / Q000469:parasitology; D005260:Female; D008099:Liver / Q000469:parasitology; D008297:Male; D008642:Mesenteric Veins / Q000469:parasitology; D051379:Mice; D010270:Parasite Egg Count / Q000379:methods; D011223:Praziquantel / Q000494:pharmacology; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D013454:Sulfoxides / Q000494:pharmacology; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D013454:Sulfoxides; D000077682:Triclabendazole; D011223:Praziquantel; C085104:triclabendazole sulfoxide