title: [Clinical and morphological characteristics of lupus nephritis in systemic lupus erythematosus with antiphospholipid syndrome].
abstract: OBJECTIVE
  To ascertain clinical and morphological features of lupus nephritis (LN) in systemic lupus erythematosus (SLE) associated with antiphospholipid syndrome (APS).
  
  
  METHODS
  Immunological markers of SLE and APS, clinical picture, urine indices were examined in 138 patients with SLE, APS and renal dysfunction.
  
  
  RESULTS
  LN associated with APS is characterized with marked arterial hypertension, such patients had arterial thromboses more frequently than patients with isolated LN. Patients with anticardiolipin antibodies have arteriolosclerosis, in APS - diffuse interstitial sclerosis.
  
  
  CONCLUSIONS
  Renal impairment in SLE may run not only with LN but also with thrombotic microangiopathy modifying clinical symptoms and course of the disease.
authors.forename: N L
authors.initials: NL
authors.lastname: Kozlovskaia
authors.forename: E M
authors.initials: EM
authors.lastname: Shilov
authors.forename: N A
authors.initials: NA
authors.lastname: Meteleva
authors.forename: V A
authors.initials: VA
authors.lastname: Varshavskiĭ
authors.forename: N G
authors.initials: NG
authors.lastname: Miroshnichenko
authors.forename: N A
authors.initials: NA
authors.lastname: Samokishina
authors.forename: A G
authors.initials: AG
authors.lastname: Serova
authors.forename: S G
authors.initials: SG
authors.lastname: Nesterova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D008181:Lupus Nephritis / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology