title: Low CD4+ T cell nadir is an independent predictor of lower HIV-specific immune responses in chronically HIV-1-infected subjects receiving highly active antiretroviral therapy.
abstract: The influence of CD4(+) T cell nadirs on human immunodeficiency virus (HIV)-specific immune responses in subjects with apparently normal CD4(+) T cell counts is not known. We evaluated the frequency of HIV-1-specific immune responses in a cohort of patients with complete viral suppression (HIV-1 RNA load, <50 copies/mL) who were receiving highly active antiretroviral therapy and had a wide range of CD4(+) T cell nadirs. We found positive associations between CD4(+) T cell nadirs and the magnitude of HIV-specific CD8(+) T cell responses (P=.02) and of T cell helper responses (P=.04). These data show the CD4(+) T cell nadir to be an independent predictor of HIV-specific CD4(+) and CD8(+) T cell responses in HIV-1-infected subjects with optimal suppression of viremia.
authors.affiliation: Department of Medicine, Infectious Diseases Unit, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
authors.forename: M Atif
authors.initials: MA
authors.lastname: Siddique
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Hartman
authors.forename: Ella
authors.initials: E
authors.lastname: Dragileva
authors.forename: Marla
authors.initials: M
authors.lastname: Dondero
authors.forename: Tebeb
authors.initials: T
authors.lastname: Gebretsadik
authors.forename: Ayumi
authors.initials: A
authors.lastname: Shintani
authors.forename: Laurence
authors.initials: L
authors.lastname: Peiperl
authors.forename: Fred
authors.initials: F
authors.lastname: Valentine
authors.forename: Spyros A
authors.initials: SA
authors.lastname: Kalams
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D008213:Lymphocyte Activation; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D012367:RNA, Viral