title: [Distribution and expression of peroxisome proliferator activated receptor gamma in human pituitary adenomas].
abstract: OBJECTIVE
  To evaluate the distribution and expression of peroxisome proliferator activated receptor gamma (PPAR-gamma) in human pituitary adenomas.
  
  
  METHODS
  Thirty eight consecutive surgically resected pituitary adenomas and 5 normal pituitary tissues were enrolled in the study. Immunohistochemistry was used to confirm the distribution of PPAR-gamma. Expression of PPAR-gamma was evaluated by Western blot.
  
  
  RESULTS
  PPAR-gamma immunoreactivity was located in the nucleoli of pituitary adenoma cells. PPAR-gamma was expressed in all human pituitary adenomas and normal pituitary tissues. Its expression in pituitary adenomas was significantly higher than in normal pituitary tissues (P < 0.01), and its expression in ACTH-secreting adenomas was significantly higher than in any other type of pituitary adenomas (P < 0.05).
  
  
  CONCLUSIONS
  PPAR-gamma may play an important role in the generation, growth, and invasion of human pituitary adenomas. It may become a novel therapeutic target for these tumors.
authors.affiliation: Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Xia
authors.forename: Chang-Bao
authors.initials: CB
authors.lastname: Su
authors.forename: Yan-Guo
authors.initials: YG
authors.lastname: Kong
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000378:metabolism*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000096:biosynthesis* / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism*
chemical_list: D047495:PPAR gamma