Chronic inflammatory demyelinating polyneuropathy associated with idiopathic hemochromatosis.
We describe a 50-year-old woman who developed chronic inflammatory demyelinating polyneuropathy (CIDP) one year after onset of hemochromatosis. Electrodiagnostic studies showed evidence of multifocal demyelination. Marked hypergammaglobulinemia with positive anti-nuclear and anti-DNA antibodies was found. Corticosteroid treatment resulted in a significant lessening of neurological symptoms. This is the first case of CIDP with hemochromatosis. The association may be coincidental, but the altered immune system by hemochromatosis was possibly related to the development of CIDP in this patient.
Misawa
Sonoko
S
Department of Neurology, Chiba University School of Medicine, Chiba.
Kuwabara
Satoshi
S
Matsuda
Shinji
S
Sakakibara
Yumi
Y
Ogawa
Yoshitsugu
Y
Tashiro
Jun
J
Hattori
Takamichi
T
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000032:analysis; D004568:Electrodiagnosis; D005260:Female; D006432:Hemochromatosis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis / Q000276:immunology; D007107:Immune System / Q000503:physiopathology; D008875:Middle Aged; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear