Potentiation of ethanol in spatial memory deficits induced by some benzodiazepines.
Triazolam caused no significant increase in the total error at 0.05 and 0.1 mg/kg. However, at 0.2 mg/kg, it caused a significant increase in total error. Almost the same findings were observed with brotizolam and rilmazafone. That is, at 0.2 and 0.5 mg/kg of brotizolam, 0.5 and 1.0 mg/kg of rilmazafone caused no significant increase in the total error. However, brotizolam at 1.0 mg/kg and rilmazafone at 2.0 mg/kg caused a significant increase in total error. Triazolam (0.05 mg/kg) and ethanol (1.0 g/kg) showed no significant effect on the numbers of errors when used alone separately, but the simultaneous use of triazolam and ethanol caused a significant increase in total error. Almost the same findings were observed with the coadministration of brotizolam (0.2 mg/kg) or rilmazafone (0.5 mg/kg) with ethanol. These results clearly indicate that all the short-acting benzodiazepines used in the study showed potentiation by ethanol in spatial memory deficits in mice.
Takiguchi
Atsushi
A
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Masuoka
Takayoshi
T
Yamamoto
Yasuko
Y
Mikami
Azusa
A
Kamei
Chiaki
C
D000818:Animals; D001381:Azepines / Q000008:administration & dosage / Q000633:toxicity; D001569:Benzodiazepines / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000503:physiopathology*; D051379:Mice; D013028:Space Perception; D013037:Spatial Behavior / Q000187:drug effects*; D014229:Triazolam / Q000008:administration & dosage / Q000633:toxicity; D014230:Triazoles / Q000008:administration & dosage / Q000633:toxicity
D001381:Azepines; D014230:Triazoles; D001569:Benzodiazepines; D014229:Triazolam; D000431:Ethanol; C020960:brotizolam; C041075:rilmazafone