title: t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma.
abstract: Diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation is occasionally seen in the gastrointestinal tract, but has rarely been reported in the thyroid gland. We experienced two cases of primary thyroid DLBCL having t(8;14)(q24;q32). The immunophenotype and karyotype of Case 1 (66-year-old female) and Case 2 (70-year-old female) were: CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) and CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32), respectively. Although long-term complete remission could be achieved in both of our patients by conventional chemotherapy with/without radiation therapy, accumulation of further such cases is necessary to develop a standard treatment protocol and also to elucidate the pathogenesis of t(8;14)(q24;q32)-positive primary thyroid DLBCL.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma-Gun, Saitama, Japan. nniitsu@saitama-med.ac.jp
authors.forename: Nozomi
authors.initials: N
authors.lastname: Niitsu
authors.forename: Masataka
authors.initials: M
authors.lastname: Okamoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nakamine
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.forename: Masami
authors.initials: M
authors.lastname: Bessho
authors.forename: Masami
authors.initials: M
authors.lastname: Hirano
authors.forename: Ikuo
authors.initials: I
authors.lastname: Miura
mesh_terms: D000368:Aged; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D015260:Neprilysin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D015260:Neprilysin