title: Consumption of juice fortified with oregano extract markedly increases excretion of phenolic acids but lacks short- and long-term effects on lipid peroxidation in healthy nonsmoking men.
abstract: Oregano has been shown to possess antioxidant capacity in various in vitro models and has thus been suggested to be potentially beneficial to human health, but studies in humans are lacking. The aim of this study was to investigate the bioavailability and the effects of Origanum vulgare extract supplementation on serum lipids and lipid peroxidation in healthy nonsmoking men. A four-week double-blinded supplementation trial was concluded in which volunteers (n = 45) were randomized to consume daily mango-orange juice (placebo), mango-orange juice enriched with 300 mg/d total phenolic compounds from oregano extract, or mango-orange juice enriched with 600 mg/d total phenolic compounds from oregano extract. The excretion of phenolic compounds was markedly increased in the higher phenolic group as compared to the placebo group, but no significant changes were observed in the safety parameters, serum lipids, or biomarkers of lipid peroxidation.
authors.affiliation: Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Nurmi
authors.forename: Jaakko
authors.initials: J
authors.lastname: Mursu
authors.forename: Tarja
authors.initials: T
authors.lastname: Nurmi
authors.forename: Kristiina
authors.initials: K
authors.lastname: Nyyssönen
authors.forename: Georg
authors.initials: G
authors.lastname: Alfthan
authors.forename: Raimo
authors.initials: R
authors.lastname: Hiltunen
authors.forename: Jari
authors.initials: J
authors.lastname: Kaikkonen
authors.forename: Jukka T
authors.initials: JT
authors.lastname: Salonen
authors.forename: Sari
authors.initials: S
authors.lastname: Voutilainen
mesh_terms: D001628:Beverages / Q000032:analysis*; D001682:Biological Availability; D002957:Citrus; D004311:Double-Blind Method; D005527:Food, Fortified / Q000032:analysis*; D005638:Fruit; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D031022:Mangifera; D031341:Origanum / Q000737:chemistry*; D010636:Phenols / Q000652:urine*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012907:Smoking
chemical_list: D008055:Lipids; D010636:Phenols; D010936:Plant Extracts