Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues.
Two series of dioscin derivatives (4a-o and 5a-o) with selected modifications at the 6' and 4''' positions of the chacotriosyl residue, respectively, were synthesized. All the 6'-N-acyl-dioscin derivatives did not show considerable inhibitory activities at 10 microM, while most of the 4'''-O-(2-N-acyl)ethyl-dioscin derivatives behaved as potent as dioscin, against the growth of tumor cells.
Zhu
Shilei
S
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Zhang
Yichun
Y
Li
Ming
M
Yu
Jia
J
Zhang
Lihong
L
Li
Yingxia
Y
Yu
Biao
B
D045744:Cell Line, Tumor; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D014326:Tropanes / Q000737:chemistry*
D014326:Tropanes; C433845:chacotriose; C019357:dioscin; D004144:Diosgenin