A novel HLA-A*0119 allele of a Caucasian family containing a mutation in a highly conserved region.
A novel human leucocyte antigen (HLA)-A (HLA-A*0119) allele has been identified in two individuals of a Caucasian family from Middle Europe using a single-allele-specific sequencing strategy. This allele is identical to the HLA-A*0101 allele except for one point mutation in the highly conserved codon 92 (TCT --> GCT) resulting in an amino acid change from serine to alanine.
Schlaf
G
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Institute of Medical Immunology, Interbranch HLA-Laboratory, Martin Luther University Halle-Wittenberg, Halle, Germany.
Wahle
A
A
Seliger
B
B
Altermann
W W
WW
D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D005091:Exons; D005190:Family; D005260:Female; D015234:HLA-A Antigens / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007951:Leukemia, Myeloid; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D044465:White People / Q000235:genetics
D015234:HLA-A Antigens