Boronated thymidine analogues for boron neutron capture therapy.
Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.
Thirumamagal
B T S
BT
College of Pharmacy, The Ohio State University, Columbus, Ohio 43120, USA.
Johnsamuel
Jayaseharan
J
Cosquer
Guirec Y
GY
Byun
Youngjoo
Y
Yan
Junhua
J
Narayanasamy
Sureshbabu
S
Tjarks
Werner
W
Barth
Rolf F
RF
Al-Madhoun
Ashraf S
AS
Eriksson
Staffan
S
D001896:Boron Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D016754:Boron Neutron Capture Therapy; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D010766:Phosphorylation; D013936:Thymidine / Q000031:analogs & derivatives*; D013937:Thymidine Kinase / Q000378:metabolism
D001896:Boron Compounds; D013937:Thymidine Kinase; C092717:thymidine kinase 1; D013936:Thymidine