Functional domains of the subtype 1 neurotensin receptor (NTS1).
The subtype 1 neurotensin receptor (NTS1) belongs to the family of G protein coupled receptors with seven transmembrane domains and mediates most of the known effects of neurotensin. In the past years, mutagenesis studies have allowed to delineate functional regions of the receptor involved in agonist and antagonist binding, G protein coupling, sodium sensitivity of agonist binding, and agonist-induced receptor internalization. These data are reviewed and discussed in the present paper.
Kitabgi
Patrick
P
INSERM, UMR S 732, Université Pierre et Marie Curie-Paris 6, Hopital St-Antoine, 184 rue du Faubourg St-Antoine, 75571 Paris Cedex 12, France. kitabgi@st-antoine.inserm.fr
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009496:Neurotensin / Q000819:agonists / Q000037:antagonists & inhibitors; D017434:Protein Structure, Tertiary; D018028:Receptors, Neurotensin / Q000737:chemistry* / Q000235:genetics / Q000502:physiology
D018028:Receptors, Neurotensin; C114036:neurotensin type 1 receptor; D009496:Neurotensin