title: Further improvement in IVF outcome may need more than consistency in ovarian stimulation.
abstract: It is agreed that reliability of hormonal products, starting with recombinant technology, has improved uniformity of ovarian response to a specified dosage, and that this has resulted in better pregnancy rates. Nevertheless, IVF cycle cancellation rate has not experienced a substantial decline in the last 5-10 years. We feel that further improvement will be more likely to be achieved once we gain better understanding of factors intrinsic to oocyte biology, such as oocyte ageing and oocyte depletion.
authors.affiliation: Reproductive Medicine Unit, Clinica Las Condes, Lo Fontecilla 441, Santiago, Chile. jbalmace@clinicalascondes.cl
authors.forename: Jose P
authors.initials: JP
authors.lastname: Balmaceda
authors.forename: Juan-Enrique
authors.initials: JE
authors.lastname: Schwarze
mesh_terms: D005260:Female; D005307:Fertilization in Vitro / Q000592:standards*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D043373:Follicle Stimulating Hormone, Human / Q000627:therapeutic use; D015292:Glycoprotein Hormones, alpha Subunit / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D010062:Ovulation Induction / Q000592:standards*; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D043373:Follicle Stimulating Hormone, Human; D015292:Glycoprotein Hormones, alpha Subunit; D005640:Follicle Stimulating Hormone