[Transplantation-associated infections].
Transplantation-associated infections are caused by an infected transplanted organ or the endogenic or exogenic environment of the recipient in a state of induced immunodeficiency. The best therapy would be to reconstitute the immunodeficiency, but this is usually impossible as it endangers the transplanted organ. Thus, a specific, standardised anti-infectious therapy is needed even in the absence of clearly identified micro-organisms [bacteria (in two thirds gram-positive rods), parasites (in central Europe predominantly Toxoplasma), fungi (especially Candida spp. or Aspergillus spp.) or viruses (such as Parvovirus B19 and Cytomegalovirus)]. Origins of infection (e.g., hygiene), types of infection (e.g., reactivation), typical localisations, diagnostic tools (e.g., blood cultures, antigenic tests, PCR, CT, advantages and disadvantages of antibody assays) and possible therapies are briefly discussed. The take home messages are to avoid economy measures in microbial diagnostics and to use CMV-seronegative donors whenever possible.
Würzner
R
R
Department für Hygiene, Mikrobiologie und Sozialmedizin, Medizinische Universität Innsbruck & Ludwig-Boltzmann-Institute for AIDS-Research, Innsbruck, Austria.
D002176:Candida albicans / Q000302:isolation & purification; D003140:Communicable Disease Control; D004926:Escherichia coli / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D006920:Hygiene; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000209:etiology / Q000473:pathology; D007239:Infections / Q000145:classification / Q000209:etiology* / Q000473:pathology; D016377:Organ Transplantation / Q000009:adverse effects*; D013291:Streptococcus / Q000302:isolation & purification; D014181:Transplantation Immunology