title: Corneal asphericity and visual function after wavefront-guided LASIK.
abstract: OBJECTIVE
  In recent years, a theory has been advanced that corneal asphericity in and of itself determines visual function; that the natural, optimal shape of the cornea is prolate; and that changing the cornea from prolate to oblate negatively impacts visual results. This article presents an analysis of the impact of corneal asphericity on wavefront-guided LASIK.
  
  
  METHODS
  A retrospective analysis was conducted of 160 myopic eyes that had undergone wavefront-guided LASIK. Surgical procedures and data collection were conducted at six clinical sites. Corneal topography, visual acuity, and contrast sensitivity data were collected before and 6 months after surgery. The topographically measured corneal surface of each eye was fitted to a conic, and a Q-value was computed for a 5.5-mm pupil. Multivariate regression analysis was performed to evaluate the correlation between Q-value and visual function. The relationship of changes in the corneal surfaces to visual performance was also investigated.
  
  
  RESULTS
  Preoperative corneas exhibited negative (prolate) conic shape constants. Postoperative corneas were about equally divided between positive (oblate) and negative conics. There was no statistically significant correlation between corneal shape and visual acuity or contrast sensitivity function. Changes in corneal asphericity after surgery had no significant correlation with changes in visual acuity or contrast sensitivity.
  
  
  CONCLUSIONS
  Visual acuity and contrast sensitivity after wavefront-guided LASIK are not dependent on corneal asphericity. Neither preserving nor inducing asphericity ensures better visual outcome. Better visual outcomes are more likely to result from the application of a customized shape than a standard conic shape.
authors.affiliation: VISX, Incorporated, Santa Clara, CA, USA. ashley.tuan@amo-inc.com
authors.forename: Kuang-mon Ashley
authors.initials: KM
authors.lastname: Tuan
authors.forename: Dimitri
authors.initials: D
authors.lastname: Chernyak
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D015350:Contrast Sensitivity / Q000502:physiology*; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D009216:Myopia / Q000601:surgery*; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology*