title: What is ZAP-70?
abstract: Zap-70, a crucial molecule for the selective activation of T cells, through its interaction with the zeta chain of the TCR/CD3 complex, is a tyrosine kinase. This well studied molecule has gained a renewed interest upon the demonstration of its transduction and expression in B cells from patients with chronic lymphocytic leukemia. Here the major characteristics of this cytosolic protein are reviewed, as well as its expression in various cell types and some indications about its detection.
authors.affiliation: Immunology Laboratory, Faculty of Medicine & CHU, Nancy, France. marie-christine.bene@medecine.uhp-nancy.fr
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Béné
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000032:analysis / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D011948:Receptors, Antigen, T-Cell; D051746:ZAP-70 Protein-Tyrosine Kinase