Triamcinolone acetonide-induced ocular hypertension.
OBJECTIVE
The aim of this study is to report on the clinical course of a patient showing markedly increased intraocular pressure (IOP) caused by intravitreal triamcinolone acetonide.


METHODS
A 33-year-old patient received an intravitreal injection of approximately 20 mg of triamcinolone acetonide (TA) as treatment of otherwise therapy-resistant uveitis. She experienced an IOP rise to values over 40 mmHg for a period for more than 3 months, despite maximal antiglaucomatous medical therapy. Peak IOP was 55 mmHg.


RESULTS
Neither confocal scanning laser tomography nor qualitative assessment of optic disc photographs nor perimetry showed development of glaucomatous changes. Scanning laser polarimetry of the retinal nerve fiber layer suggested a slight loss in the nasal upper fundus quadrant.


CONCLUSIONS
Relatively young patients with a pronounced TA-induced rise in IOP, unresponsive to maximal antiglaucomatous medication, may not necessarily undergo antiglaucomatous surgery if the rise in IOP does not last longer than approximately 3 months.
Jonas
Jost B
JB
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany. Jost.Jonas@augen.ma.uni-heidelberg.de
Sauder
Gangolf
G
Budde
Wido M
WM
Spandau
Ulrich H M
UH
Kamppeter
Bernd A
BA
Harder
Bjoern
B
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007834:Lasers; D009412:Nerve Fibers / Q000187:drug effects / Q000473:pathology; D009798:Ocular Hypertension / Q000139:chemically induced*; D009898:Optic Disk / Q000187:drug effects / Q000473:pathology; D009901:Optic Nerve Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D014054:Tomography; D014222:Triamcinolone Acetonide / Q000009:adverse effects*; D014605:Uveitis / Q000188:drug therapy
D000959:Antihypertensive Agents; D005938:Glucocorticoids; D014222:Triamcinolone Acetonide