Biological cost of fluoroquinolone resistance in Escherichia coli implicated in polyclonal infection.
Polyclonal Escherichia coli strains were isolated in a transplanted patient who experienced successive septic shocks. Fluoroquinolone susceptible and resistant strains were corresponding to different PFGE fragment profiles. The gyrA S83L mutation was associated with a reduction in biological fitness. Resistant strain was selected by a long-term single use of ofloxacin.
Bémer
P
P
Department of Microbiology, CHU Hôtel-Dieu, 9, quai Moncousu, 44093 Nantes cedex 01, France. pascale.bemer@chu-nantes.fr
Corvec
S
S
Guitton
C
C
Giraudeau
C
C
Le Gargasson
G
G
Espaze
E
E
Drugeon
H
H
D024881:Drug Resistance, Bacterial; D004927:Escherichia coli Infections / Q000188:drug therapy*; D017809:Fatal Outcome; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000382:microbiology*
D024841:Fluoroquinolones