Tissue helminthes larvae as the first xenotransplants in mammal and human evolution.
The review aims at explaining the role of larvae of tissue helminthes in suppression of protective responses of the host during xenotransplantation. We analyse the influence of invasion in the host by larvae of tissue helminths on the development of the graft against host reaction. The role of secrets and excrets of parasites in suppression of protective responses of the host is clarified at allotransplantation. The author considers the nature of immunodepressive components generated with larvae of helminthes in preventing response of the graft against host reaction. The role of corticosteroids and eicosanoids, secreted by parasites, in suppression of immune responses of the host is estimated at allotransplantation.
Bekish
O J
OJ
Vitebsk State Medical University, Vitebsk, 27 Frunze ave., Belarus.
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis*; D000947:Antigens, Helminth / Q000378:metabolism; D005075:Biological Evolution; D006086:Graft vs Host Disease / Q000276:immunology*; D006373:Helminthiasis / Q000276:immunology* / Q000469:parasitology; D006376:Helminths / Q000472:pathogenicity*; D006790:Host-Parasite Interactions; D006801:Humans; D008322:Mammals; D014183:Transplantation, Heterologous / Q000276:immunology*
D000909:Antibodies, Helminth; D000947:Antigens, Helminth