title: Vascular wall elasticity measurement by magnetic resonance imaging.
abstract: The goal of this current study was to determine whether an MRI-based elastography (MRE) method can visualize and assess propagating mechanical waves within fluid-filled vessels and to investigate the feasibility of measuring the elastic properties of vessel walls and quantitatively assessing stenotic lesions by using MRE. The ability to measure the Young's modulus-wall thickness product was tested using a thin-walled latex vessel model. Also tested in vessel models was the ability to quantitate the degree of stenosis by measuring transmitted and reflected mechanical waves. This method was then applied to ex vivo porcine models and in vivo human arteries to further test its feasibility. The results provide preliminary evidence that MRE can be used to quantitatively assess the stiffness of blood vessels, and provide a non-morphologic method to measure stenosis. With further development, it is possible that the method can be implemented in vivo.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Woodrum
authors.forename: A J
authors.initials: AJ
authors.lastname: Romano
authors.forename: A
authors.initials: A
authors.lastname: Lerman
authors.forename: U H
authors.initials: UH
authors.lastname: Pandya
authors.forename: D
authors.initials: D
authors.lastname: Brosh
authors.forename: P J
authors.initials: PJ
authors.lastname: Rossman
authors.forename: L O
authors.initials: LO
authors.lastname: Lerman
authors.forename: R L
authors.initials: RL
authors.lastname: Ehman
mesh_terms: D000465:Algorithms; D000818:Animals; D001158:Arteries / Q000033:anatomy & histology* / Q000502:physiology*; D003198:Computer Simulation; D004548:Elasticity; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D016247:Information Storage and Retrieval / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength; D013314:Stress, Mechanical; D013552:Swine