[Effect of sodium fluoride on the activity of sorbitol dehydrogenase in plasma and liver of rabbits with experimental atherosclerosis].
This study was done in rabbits placed on a low-cholesterol (0.5 g%) and high-cholesterol (2.0 g%) diet to induce experimental atherosclerosis. The intake of fluorine in the form of NaF in water was 3 mg F(-)/kg b.w./24 h. The activity of sorbitol dehydrogenase (SDH) was increased in plasma and decreased in the liver of rabbits on the high-cholesterol diet and in animals simultaneously exposed to NaF in water. Two months of the low-cholesterol diet produced an increase in SDH activity in plasma as a direct consequence of exposure to fluoride in the diet and presumably caused by accumulation of fluoride in the liver.
Birkner
Ewa
E
Zakład Biochemii Ogólnej Katedry Biochemii w Zabrzu Slaskiej Akademii Medycznej w Katowicach ul. Jordana 19, 41-808 Zabrze.
Grucka-Mamczar
Ewa
E
Kasperczyk
Sławomir
S
Kasperczyk
Aleksandra
A
Zalejska-Fiolka
Jolanta
J
Birkner
Beata
B
Pieczyrak
Beata
B
D000818:Animals; D050197:Atherosclerosis / Q000139:chemically induced / Q000201:enzymology*; D002791:Cholesterol, Dietary; D007064:L-Iditol 2-Dehydrogenase / Q000187:drug effects*; D008099:Liver / Q000201:enzymology*; D011817:Rabbits; D012969:Sodium Fluoride / Q000494:pharmacology*
D002791:Cholesterol, Dietary; D012969:Sodium Fluoride; D007064:L-Iditol 2-Dehydrogenase