title: Prenylated xanthones as potential antiplasmodial substances.
abstract: Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed.
authors.affiliation: Department of Chemistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand. wilawan.m@psu.ac.th
authors.forename: Wilawan
authors.initials: W
authors.lastname: Mahabusarakam
authors.forename: Kunnika
authors.initials: K
authors.lastname: Kuaha
authors.forename: Prapon
authors.initials: P
authors.lastname: Wilairat
authors.forename: Walter C
authors.initials: WC
authors.lastname: Taylor
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D029762:Garcinia mangostana / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D000962:Antimalarials; D044004:Xanthones; C021053:mangostin