title: Epidemiology of HIV-1 infection in agricultural plantation residents in Kericho, Kenya: preparation for vaccine feasibility studies.
abstract: A cross-sectional study was performed to determine the prevalence and risk factors for HIV-1 infection among agricultural plantation residents in Kericho, Kenya. Volunteers were recruited, interviewed, and phlebotomized for HIV-1 serologic testing. Sex-specific adjusted odds ratios were estimated using logistic regression. The overall HIV-1 prevalence was 9.9% (81/820), with prevalence in women more than twice that in men (17.4% vs 8.0%, P=0.001). Among men, elevated HIV-1 prevalence was seen with increasing age, peaking in those older than 30 years (10.3%), marriage (10.4%), Luo tribe affiliation (23.5%), employment (8.9%), travel (11.0%), and being uncircumcised (29.2%). Among women, elevated HIV-1 prevalence was seen in those with no formal education (36.8%) and those who received goods in exchange for sex (36.0%). More than 97% of volunteers expressed a willingness to participate in future HIV-1 studies requiring semiannual visits. HIV prevention efforts have been implemented, along with further research to characterize this population for future cohort feasibility studies and HIV-1 vaccine efficacy trials.
authors.affiliation: US Military HIV Research Program at the Walter Reed Army Institute of Research (WRAIR), Division of Retrovirology, and the Henry M. Jackson Foundation for the Advancement Military Medicine, Inc, Rockville, MD 20850, USA. wsateren@hivresearch.org
authors.forename: Warren B
authors.initials: WB
authors.lastname: Sateren
authors.forename: Ginamarie
authors.initials: G
authors.lastname: Foglia
authors.forename: Philip O
authors.initials: PO
authors.lastname: Renzullo
authors.forename: Lynne
authors.initials: L
authors.lastname: Elson
authors.forename: Monique
authors.initials: M
authors.lastname: Wasunna
authors.forename: Christian T
authors.initials: CT
authors.lastname: Bautista
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Birx
mesh_terms: D000293:Adolescent; D000383:Agriculture / Q000706:statistics & numerical data; D019496:Cancer Vaccines; D002675:Child, Preschool; D003431:Cross-Cultural Comparison; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D015995:Prevalence
chemical_list: D019496:Cancer Vaccines