t(8;14)(q24;q32) in two patients with CD10-negative primary thyroid diffuse large B-cell lymphoma.
Diffuse large B-cell lymphoma (DLBCL) with the 8q24 translocation is occasionally seen in the gastrointestinal tract, but has rarely been reported in the thyroid gland. We experienced two cases of primary thyroid DLBCL having t(8;14)(q24;q32). The immunophenotype and karyotype of Case 1 (66-year-old female) and Case 2 (70-year-old female) were: CD10-, CD20+, BCL-2+/add(13)(q34), t(8;14)(q24;q32) and CD10-, CD20-, CD79a+, BCL-2-/t(8;14)(q24;q32), respectively. Although long-term complete remission could be achieved in both of our patients by conventional chemotherapy with/without radiation therapy, accumulation of further such cases is necessary to develop a standard treatment protocol and also to elucidate the pathogenesis of t(8;14)(q24;q32)-positive primary thyroid DLBCL.
Niitsu
Nozomi
N
Division of Hematology, Department of Internal Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma-Gun, Saitama, Japan. nniitsu@saitama-med.ac.jp
Okamoto
Masataka
M
Yoshino
Tadashi
T
Nakamine
Hirokazu
H
Nakamura
Naoya
N
Bessho
Masami
M
Hirano
Masami
M
Miura
Ikuo
I
D000368:Aged; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D015260:Neprilysin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000532:radiotherapy; D014178:Translocation, Genetic / Q000235:genetics*
D015260:Neprilysin