[Spectrophotometric determination of azithromycin by charge transfer reaction].
The charge transfer interactions of Azithromycin and 7,7,8,8-tetracyanoquinodimethane (TCNQ) or chloranilic acid (CL) were investigated by spectrophotometry. The apparent molar absorptivity of TCNQ complex is 2.7 x 10(4) L x mol(-1) x cm(-1) at 743 nm, and 5.0 x 10(4) L x mol(-1) x cm(-1) at 842 nm; and that of CL complex is 2.4 x 10(3) L x mol(-1) x cm(-1). Beers law is obeyed in the concentration range of 0-30 mg x L(-1) for TCNQ method, and 5-225 mg x L(-1) for CL method. The relative standard deviations of the two methods are 1.0% and 1.4% (n = 6), respectively. The composition of complex of Azithromycin with 7,7,8,8-tetracyanoquinodimethane or chloranilic acid is 1 : 2. This proposed method has been applied to the determination of Azithromycin in tablets with satisfactory results.
Huang
Wei
W
Zaozhuang College, Zaozhuang 277100, China.
Liu
Xue-Jing
XJ
Zhao
Feng-Lin
FL
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D017963:Azithromycin / Q000737:chemistry*; D016227:Benzoquinones / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*
D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D009570:Nitriles; C013703:tetracyanoquinodimethane; D017963:Azithromycin; C014400:chloranilic acid