Diastereoselective cobalt-catalyzed reductive aldol cyclizations using diethylzinc as the stoichiometric reductant.
[reaction: see text] Cobalt catalysis enables a new method for the generation of zinc enolates using diethylzinc to reduce alpha,beta-unsaturated amides. This method has been applied to a high-yielding diastereoselective reductive aldol cyclization.
Lam
Hon Wai
HW
School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, United Kingdom. h.lam@ed.ac.uk
Joensuu
Pekka M
PM
Murray
Gordon J
GJ
Fordyce
Euan A F
EA
Prieto
Oscar
O
Luebbers
Thomas
T