Left bundle branch block as a risk factor for progression to heart failure.
The prevalence of conduction disturbances, particularly left bundle branch block (LBBB), is strongly correlated with age and with the presence of cardiovascular disease. LBBB has been reported to affect approximately 25% of the heart failure (HF) population and it is likely that the deleterious role of such conduction disorders in the progression to HF has been underestimated. The purpose of this article is to review the data from the literature indicating that LBBB may have a causative role, mediated through the resulting intra-ventricular asynchrony, in the deterioration of cardiac function and the development of cardiac remodelling and HF. It also aims to address the potential for future clinical therapies for this conduction disorder.
Zannad
Faiez
F
CIC-INSERM-CHU de Nancy, Hôpital Jeanne d'Arc, Dommartin-lès-Toul, BP 303 - 54201 Toul Cedex, France. f.zannad@chu-nancy.fr
Huvelle
Etienne
E
Dickstein
Kenneth
K
van Veldhuisen
Dirk J
DJ
Stellbrink
Christoph
C
Køber
Lars
L
Cazeau
Serge
S
Ritter
Philippe
P
Maggioni
Aldo Pietro
AP
Ferrari
Roberto
R
Lechat
Philippe
P
D002037:Bundle-Branch Block / Q000150:complications / Q000503:physiopathology*; D018450:Disease Progression; D007839:Functional Laterality; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology