[How to improve efficacy of onychomycosis treatment?].
Onychomycosis is a public health concern because of its high world wide prevalence, and its potential for spread of fungal elements to others. About one half of all patients presenting to dermatologists' offices for nail disorders have onychomycosis. This kind of infection may impact upon physical, functional, and emotional aspects of life. Onychomycosis can be treated with the new generation of oral antifungals. Efficacy rates for fingernail onychomycosis are high; however, for toenail onychomycosis, efficacy rates may range from 60% to 80%. Relapse rates have been estimated to be 15% to 20% measured at 2 years following therapy initiation. Because many factors may be associated with a suboptimal clinical response, consideration to measures that reflect the most appropriate pharmacologic and supportive regimens must be made in order to meet the challenge of onychomycosis cure. In some situations supplemental therapy consisting of extra antifungal or adjunctive (topical/surgical) therapy may be beneficial.
Nowicki
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Katedra i Klinika Chorób Skórnych i Wenerycznych AM w Gdańsku, 80-211 Gdańsk, ul Debinki 7.
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000627:therapeutic use; D005533:Foot Dermatoses / Q000175:diagnosis / Q000628:therapy*; D006229:Hand Dermatoses / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009260:Nail Diseases / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D014009:Onychomycosis / Q000175:diagnosis / Q000628:therapy*; D020551:Pulse Therapy, Drug / Q000379:methods; D011728:Pyridones / Q000627:therapeutic use
D000935:Antifungal Agents; D011728:Pyridones; D015725:Fluconazole