[Chronic renal disease in boys with posterior urethral valve].
Posterior urethral valve (PUV) is the most common anatomical cause of bladder outlet obstruction with an incidence ranging from 1/3000 to 1/8000 births. In spite of early valve ablation deterioration of renal function is frequently reported during childhood and adolescence.


OBJECTIVE
To evaluate the frequency and progression of chronic renal disease in boys born with PUV.


METHODS
The presence of chronic renal disease (CRD) in 58 boys with posterior urethral valve (PUV) was assessed by renal ultrasound and estimation of glomerular filtration rate (GFR). GFR was estimated by the method of Schwartz. Chronic renal disease was defined according to NFK K/DOQI Guidelines and classified into 5 stages.


RESULTS
48 (82%) patients with PUV had CRD. Among the patients observed from birth 89% already demonstrated CRD in the first year of life.


CONCLUSIONS
1. The vast majority of boys with PUV (83%) demonstrate symptoms of chronic renal disease. 2. CRD in boys with PUV is frequently evident from the first year of life. 3. PUV patients require regular nephrologic assessment from birth.
Maternik
Michał
M
Klinika Nefrologii Dzieciecej, Akademii Medycznej w Gdańsku. mmaternik@amg.gda.pl
Zurowska
Aleksandra
A
Czarniak
Piotr
P
Drozyńska-Duklas
Magdalena
M
Kosiak
Wojciech
W
Gołebiewski
Andrzej
A
D000293:Adolescent; D002675:Child, Preschool; D002908:Chronic Disease; D015897:Comorbidity; D018450:Disease Progression; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D014463:Ultrasonography; D014521:Urethra / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D001748:Urinary Bladder Neck Obstruction / Q000453:epidemiology