Perospirone in treatment of Huntington's disease: a first case report.
Huntington's disease (HD) is a hereditary disorder clinically characterized by involuntary movements, cognitive decline and psychiatric symptoms. We report on a patient with HD, whose involuntary movements and psychiatric symptoms were clinically improved with perospirone, a second-generation antipsychotic agent with antagonistic effects on serotonin 5-HT(2A) and dopamine D(2) (D(2)) receptors, as well as a unique agonistic effect on serotonin 5-HT(1A) (5-HT(1A)) receptors. The fact that perospirone antagonizes D(2) receptors could explain its effects on the hyperkinetic syndrome, while its agonistic effects on 5-HT(1A) receptors may explain the amelioration of psychiatric symptoms (fear and anxiety) in this patient. Future studies would be valuable to elucidate the utility of perospirone for the treatment of involuntary movements and psychiatric symptoms in HD.
Roppongi
Tomohide
T
Department of Psychiatry, Yokohama City University School of Medicine: 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Togo
Takashi
T
Nakamura
Shinichi
S
Asami
Takeshi
T
Yoshimi
Asuka
A
Shiozaki
Kazumasa
K
Kato
Daiji
D
Kawanishi
Chiaki
C
Hirayasu
Yoshio
Y
D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001007:Anxiety / Q000150:complications / Q000188:drug therapy; D018492:Dopamine Antagonists / Q000494:pharmacology; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy* / Q000235:genetics / Q000523:psychology; D007211:Indoles / Q000009:adverse effects / Q000627:therapeutic use*; D054833:Isoindoles; D001523:Mental Disorders / Q000188:drug therapy / Q000209:etiology; D009483:Neuropsychological Tests; D012702:Serotonin Antagonists / Q000494:pharmacology; D013844:Thiazoles / Q000009:adverse effects / Q000627:therapeutic use*
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D007211:Indoles; D054833:Isoindoles; D012702:Serotonin Antagonists; D013844:Thiazoles; C065533:perospirone