title: Highly efficient alkylation to ketones and aldimines with Grignard reagents catalyzed by zinc(II) chloride.
abstract: A highly efficient alkylation to ketones and aldimines with Grignard reagents in the presence of catalytic trialkylzinc(II) ate complexes derived from ZnCl2 (10 mol %) in situ was developed. This simple Zn(II)-catalyzed alkylation could minimize the well-known but serious problems with the use of only Grignard reagents, which leads to reduction and aldol side products, and the yield of desired alkylation products could be improved.
authors.affiliation: Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hatano
authors.forename: Shinji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishihara