[Fluoroquinolone induced acute renal failure. General review about a case report with crystalluria due to ciprofloxacin].
A 58 year-old woman developed an acute renal failure very quickly after ingestion of two 500 mg tablets of ciprofloxacin, without any other identifiable risk factor. Renal biopsy was performed. No sign of acute interstitial nephritis was observed but tubular lesions were found, accompanied by deposits of a brown-yellowish substance identified by infrared microscopy as a ciprofloxacin salt. The outcome was favourable. This observation gives the opportunity to remind the different forms of quinolone-induced renal injury and to discuss the possible ways for preventing renal side-effects related to the quinolone use.
Montagnac
Richard
R
Service de néphrologie-hémodialyse, centre hospitalier de Troyes, 10003 Troyes cedex, France. richard.montagnac@ch-troyes.fr
Briat
Claude
C
Schillinger
Francis
F
Sartelet
Hervé
H
Birembaut
Philippe
P
Daudon
Michel
M
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000009:adverse effects*; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000473:pathology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin