Streptococcus pneumoniae protein vaccine candidates: properties, activities and animal studies.
Streptococcus pneumoniae is a causative agent for community acquired pneumonia, bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant clinical isolates prompts the need of effective vaccine for the prevention of disease. The licensed polysaccharide-based pneumococcal vaccines only elicit protective antibodies against the infection of serotypes that are included in the vaccine. To broaden the protection, the use of pneumococcal proteins will be a feasible and preferable alternative. This communication provides a review on the biochemical properties of these protein candidates, their immunization results in animal studies, and perspectives on the development of protein-based pneumococcal vaccine.
Tai
Stanley S
SS
Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA. stai@howard.edu
D018829:Adhesins, Bacterial / Q000008:administration & dosage / Q000276:immunology; D000818:Animals; D001426:Bacterial Proteins / Q000008:administration & dosage* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage; D004195:Disease Models, Animal; D008074:Lipoproteins / Q000008:administration & dosage / Q000276:immunology; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000008:administration & dosage / Q000276:immunology; D009439:Neuraminidase / Q000008:administration & dosage / Q000276:immunology; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D013296:Streptococcus pneumoniae / Q000737:chemistry*; D013301:Streptolysins / Q000008:administration & dosage / Q000276:immunology
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; D022242:Pneumococcal Vaccines; C085000:PsaA protein, Streptococcus; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; C051592:pneumococcal surface protein A; D009439:Neuraminidase; D009238:N-Acetylmuramoyl-L-alanine Amidase