Arginine vasopressin in the caudate nucleus plays an antinociceptive role in the rat.
Our previous work has shown that arginine vasopressin (AVP) regulates antinociception through brain nuclei rather than the spinal cord and peripheral organs. The present study investigated the nociceptive effect of AVP in the caudate nucleus (CdN) of the rat. Microinjection of AVP into the CdN increased pain threshold in a dose-dependent manner, while local administration of AVP-receptor antagonist-d(CH(2))(5)Tyr(Et)DAVP decreased pain threshold. Pain stimulation elevated AVP concentration in CdN perfuse liquid. CdN pretreatment with AVP-receptor antagonist completely reversed AVP's effect on pain threshold in the CdN. The data suggest that AVP in the CdN is involved in antinociception.
Yang
Jun
J
Institute for Pharmaceutical and Medical Science, Guangdong Bangmin Pharmaceutical Co. Ltd., Jianghai Distract, Jiangmen, Guangdong 529000, China. yj6676@yahoo.com
Chen
Jian-Min
JM
Liu
Wen-Yan
WY
Song
Cao-You
CY
Wang
Cheng-Hai
CH
Lin
Bao-Cheng
BC
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004558:Electric Stimulation; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D011188:Potassium / Q000494:pharmacology; D051381:Rats
D001127:Arginine Vasopressin; D011188:Potassium