The effect of 7.2% hypertonic saline solution on m-mode echocardiographic indices in normovolemic dogs.
This study investigated whether a small volume of 7.2% hypertonic saline solution (HSS) could affect M-mode echocardiographic indices in dogs. HSS induced significant increase in heart rate, stroke volume and cardiac index, when the fluid infusion was completed (P<0.05). In the HSS group, the left ventricular end-diastolic volume index, as an index of preload, significantly increased (P<0.05), whereas left ventricular end-systolic volume index were not altered. HSS induced slight increases in ejection fraction at end of infusion despite significantly differences were not observed. In conclusion, HSS did not induce a demonstrable effect on M-mode echocardiographic indices of systolic function-enhance cardiac contractility, but it caused preload augmentation that may contribute to an abrupt and transient increase in cardiac output just after HSS infusion.
Suzuki
Kazuyuki
K
Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Aoyagi
Shinobu
S
Koie
Hiroshi
H
Asano
Ryuji
R
D000818:Animals; D004285:Dogs; D004452:Echocardiography / Q000379:methods*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009994:Osmolar Concentration; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects*; D013997:Time Factors
D012462:Saline Solution, Hypertonic