The effect of Ascaris trypsin inhibitor on proteolytic activity of lungs and kidneys of guinea pig with larval ascariosis and after ascarid homogenate administration.
Trypsin inhibitor, isolated from Ascaris suum tegument reduces in vitro proteolytic activity (pH 7) of lungs and kidneys post-nuclear fractions of guinea pigs with larval ascariosis, pigs after subcutaneous ascarid homogenate administration as well as the activity in control groups. The comparative analysis of effect curves of trypsin inhibitor on the organ proteases revealed stronger reduction of the activity of post-nuclear lung proteases in ascariosis and of kidneys proteases after the injection of Ascaris homogenate than the inhibition of the fractions activity from respective control groups.
Wójcik
A
A
Chair of Biology and Medical Parasitology, Medical University of Lódź, Kościuszki 85, 90-436 Lódź, Poland.
Kadłubowski
R
R
D000818:Animals; D001196:Ascariasis / Q000201:enzymology* / Q000469:parasitology; D017165:Ascaris suum / Q000254:growth & development; D010450:Endopeptidases / Q000187:drug effects* / Q000378:metabolism; D006168:Guinea Pigs; D015801:Helminth Proteins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology*; D007814:Larva / Q000254:growth & development; D008168:Lung / Q000187:drug effects / Q000201:enzymology*; D008297:Male
D015801:Helminth Proteins; C089852:trypsin inhibitor, Ascaris; D010450:Endopeptidases