title: Recurring HRAS mutation G12S in Dutch patients with Costello syndrome.
abstract: Costello syndrome (CS) is a rare multiple congenital anomaly/mental retardation syndrome characterized by coarse face, loose skin and cardiomyopathy. It is often associated with benign and malignant tumors. Several groups have now demonstrated that CS is caused by recurring mutations in the HRAS gene in different ethnic groups. Here, we describe three unrelated Dutch patients and show that they all have the same mutation, G12S, in HRAS. To our knowledge, our patients are the first Dutch to be analysed. The syndrome seems to be genetically homogeneous. We discuss the pertinent nosology of the syndrome.
authors.affiliation: Department of Dermatology, University Hospital Maastricht, Maastricht, The Netherlands. mvst@sder.azm.nl
authors.forename: M A M
authors.initials: MA
authors.lastname: van Steensel
authors.forename: M
authors.initials: M
authors.lastname: Vreeburg
authors.forename: C
authors.initials: C
authors.lastname: Peels
authors.forename: C M
authors.initials: CM
authors.lastname: van Ravenswaaij-Arts
authors.forename: E
authors.initials: E
authors.lastname: Bijlsma
authors.forename: C T
authors.initials: CT
authors.lastname: Schrander-Stumpel
authors.forename: M
authors.initials: M
authors.lastname: van Geel
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics* / Q000473:pathology; D000328:Adult; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D013577:Syndrome; D044465:White People / Q000235:genetics
chemical_list: C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)