title: Comparison of serum beta 2-microglobulin and 24 hour urinary creatinine clearance as a prognostic factor in multiple myeloma.
abstract: A new staging system for multiple myeloma (MM) has utilized serum concentrations of beta2-microglobulin (Sbeta2M) and albumin as important prognostic factors for survival. Since Sbeta2M is an indicator of glomerular filtration rate, we compared the prognostic values of Sbeta2M and 24-hr urinary creatinine clearance (Ccr) in patients with MM. We retrospectively reviewed the records of 170 MM patients from January 1996 to November 2003 whose 24-hr urinary Ccr was available at the time of diagnosis. We found that pretreatment Sbeta2M was inversely related to Ccr (Spearman's correlation coefficient=-0.787). In univariate analysis, the hazard ratio (HR) of death was 1.043 (p<0.001) for Sbeta2M and 0.985 (p<0.001) for Ccr. Multivariate analysis showed that Sbeta2M (HR 1.030, p=0.010) and Ccr (HR 0.993, p=0.059) were significant prognostic factors in patients' survival. In conclusion, 24-hr urinary Ccr may be utilized for staging of patients with MM.
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Songpa-gu, Seoul, Korea.
authors.forename: Jae-Pil
authors.initials: JP
authors.lastname: Yun
authors.forename: Cheolwon
authors.initials: C
authors.lastname: Suh
authors.forename: Eunkyoung
authors.initials: E
authors.lastname: Lee
authors.forename: Jai Won
authors.initials: JW
authors.lastname: Chang
authors.forename: Won Seok
authors.initials: WS
authors.lastname: Yang
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Park
authors.forename: Su-Kil
authors.initials: SK
authors.lastname: Park
mesh_terms: D003404:Creatinine / Q000652:urine*; D009101:Multiple Myeloma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D015999:Multivariate Analysis; D009367:Neoplasm Staging / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D001613:beta 2-Microglobulin; D003404:Creatinine