Cellular senescence and DNA repair.
Aging is a complex process that results in functional decline and mortality of the organisms. On the cellular lever, cellular senescence has been used as a model for aging. Therefore, understanding cellular senescence has important health implications. Initial observations suggest that cellular senescence is the result of telomere shortening. Recent findings suggest that cellular senescence could be triggered by DNA damage. In fact, both telomere shortening and DNA-damage-induced cellular senescence share a common mechanism, the DNA damage response pathway. This review will discuss the link between DNA repair defects and cellular senescence.
Lou
Zhenkun
Z
Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.
Chen
Junjie
J
D000375:Aging / Q000235:genetics; D000818:Animals; D016923:Cell Death / Q000235:genetics*; D004260:DNA Repair; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics; D016615:Telomere / Q000502:physiology