[Pharmacokinetics of radiotracers in the ocular tissues exposed to infrasound and ultrasound phonophoreses].
The paper compares the efficiency of infrasound and ultrasound phonophoreses. The efficiency was evaluated on the basis of the rate of radiotracers within the eye after infrasound or ultrasound exposure of the eyeball. The exposure was made after preliminary putting the radiotracer-impregnated application into the bulbar conjunctiva of an animal. Radioactivity was recorded on a Siemens gamma camera in its lifetime. The time course of changes in the radioactivities measured 10, 30, and 60 minutes after termination of exposures strongly suggests its stable increase in the eye exposed to infrasound. At the same time 10 minutes after ultrasound exposure, the increased concentration of a radiotracer in the eye was less than that after infrasound exposure and then it progressively decreased. Thus, having a significant phoretic activity, infrasound, as ultrasound, creates more favorable conditions for long drug storage in the eye.
D000287:Administration, Topical; D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage / Q000493:pharmacokinetics; D003228:Conjunctiva; D005123:Eye / Q000378:metabolism*; D015612:Phonophoresis; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013670:Sodium Pertechnetate Tc 99m / Q000008:administration & dosage / Q000493:pharmacokinetics
D019275:Radiopharmaceuticals; D002701:Chloramphenicol; D013670:Sodium Pertechnetate Tc 99m