title: Antinociceptive effect of Hyptis pectinata leaves extracts.
abstract: Oral administration of hexanes, chloroform, and ethyl acetate extracts of the leaves of Hyptis pectinata significantly reduced the number of writhing induced by acetic acid and increased the response to thermal stimuli in hot-plate test. Such effect was completely reversed by the opioid antagonist naloxone.
authors.affiliation: Physiology Department, Federal University of Sergipe, São Cristovão, Sergipe, Brazil. tlemos@ufc.br
authors.forename: Ana C C D
authors.initials: AC
authors.lastname: Lisboa
authors.forename: Iderjane C M
authors.initials: IC
authors.lastname: Mello
authors.forename: Rogeria S
authors.initials: RS
authors.lastname: Nunes
authors.forename: Marquês A
authors.initials: MA
authors.lastname: Dos Santos
authors.forename: Angelo R
authors.initials: AR
authors.lastname: Antoniolli
authors.forename: Rosilene M
authors.initials: RM
authors.lastname: Marçal
authors.forename: Sócrates C de H
authors.initials: SC
authors.lastname: Cavalcanti
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D031331:Hyptis; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid