title: Pathophysiology of leukocyte-tissue interactions.
abstract: Unlike most somatic cells, leukocytes are constitutively non-adherent. However, adhesive interactions are not only a required step in essentially all effector functions performed by leukocytes, but they also relay increasingly well-defined intracellular signals that affect the leukocyte as well as the surrounding tissues. Dissecting such signals in leukocytes has provided a wealth of information that contributes to our understanding of how adhesion controls higher-order biological responses, ranging from cell migration to proliferation, differentiation and survival.
authors.affiliation: Unit of Leukocyte Biology, Vita-Salute San Raffaele University School of Medicine, DIBIT-Scientific Institute San Raffaele, Milano, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Molteni
authors.forename: Monica
authors.initials: M
authors.lastname: Fabbri
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Bender
authors.forename: Ruggero
authors.initials: R
authors.lastname: Pardi
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D004727:Endothelium / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D007962:Leukocytes / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016023:Integrins