Spatiotemporal fluctuation-induced transition in a tumor model with immune surveillance.
We report on a simple model of spatially extended antitumor system with a fluctuation in growth rate, which can undergo a nonequilibrium phase transition. Three states as excited, subexcited and nonexcited states of a tumor are defined to describe its growth. The multiplicative noise is found to have opposite effects: The positive effect on a nonexcited tumor and the negative effect on an excited tumor.
Zhong
Wei-Rong
WR
State Key Laboratory of Optoelectronic Materials and Technologies, Department of Physics, Sun Yat-sen University, Guangzhou 510275, People's Republic of China.
Shao
Yuan-Zhi
YZ
He
Zhen-Hui
ZH
D000818:Animals; D048708:Cell Growth Processes / Q000276:immunology; D049109:Cell Proliferation; D003198:Computer Simulation; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D018448:Models, Immunological; D015233:Models, Statistical; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy