title: The vasoactive intestinal peptide receptor turnover in pulmonary arteries indicates an important role for VIP in the rat lung circulation.
abstract: Vasoactive intestinal peptide (VIP) is a potent vasorelaxing peptide that plays a role in lung physiology and possibly in pulmonary hypertension. We investigated the turnover of the VIP receptors on rat pulmonary arteries ex vivo. There was evidence for a fast receptor turnover in pulmonary arteries, which underlines the important role of VIP for the regulation of pulmonary circulation and pulmonary pathology.
authors.affiliation: Medical University Vienna, KIM-1, Institute of Cancer Research, Borschkegasse 8a, A-1090 Wien, Austria.
authors.forename: Ventzislav
authors.initials: V
authors.lastname: Petkov
authors.forename: Temenuschka
authors.initials: T
authors.lastname: Gentscheva
authors.forename: Chantal
authors.initials: C
authors.lastname: Schamberger
authors.forename: Ines
authors.initials: I
authors.lastname: Haberl
authors.forename: Andreas
authors.initials: A
authors.lastname: Artl
authors.forename: Fritz
authors.initials: F
authors.lastname: Andreae
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Mosgoeller
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D008297:Male; D011651:Pulmonary Artery / Q000187:drug effects* / Q000378:metabolism*; D011652:Pulmonary Circulation / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018005:Receptors, Vasoactive Intestinal Peptide / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
chemical_list: D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide; D000109:Acetylcholine