title: Serum TRACP 5b and ICTP as markers of bone metastases in breast cancer.
abstract: BACKGROUND
  The purpose of this cross-sectional study was to evaluate the value of serum tartrate-resistant acid phosphatase 5b (TRACP 5b) and carboxyterminal telopeptide of type I collagen (ICTP) separately and in combination as markers of bone metastases compared to total alkaline phosphatase (tALP) in breast cancer.
  
  
  METHODS
  Two groups of patients were studied, one with verfied bone metastases (N=46) and one without bone metastases (N=141). Bone marker levels were correlated with the presence or absence of bone metastases.
  
  
  RESULTS
  Serum TRACP 5b concentrations exhibited the largest area under the receiver-operating characteristics (ROC) curve (AUC=0.845), followed by ICTP (0.818) and tALP (0.814) when all patients were included in the analysis. With the combination of TRACP 5b and ICTP, the AUC increased to 0.881. In multivariate regression analysis, all three markers were significant predictors of bone metastases.
  
  
  CONCLUSIONS
  Serum TRACP 5b, ICTP and tALP exhibited equal performances in the detection of bone metastases. The combination of TRACP with ICTP did not significantly improve the detection of bone metastases over tALP.
authors.affiliation: Department of Oncology, Turku University Hospital, Turku, Finland. jaakor@utu.fi
authors.forename: J
authors.initials: J
authors.lastname: Korpela
authors.forename: S L
authors.initials: SL
authors.lastname: Tiitinen
authors.forename: H
authors.initials: H
authors.lastname: Hiekkanen
authors.forename: J M
authors.initials: JM
authors.lastname: Halleen
authors.forename: K S
authors.initials: KS
authors.lastname: Selander
authors.forename: H K
authors.initials: HK
authors.lastname: Väänänen
authors.forename: P
authors.initials: P
authors.lastname: Suominen
authors.forename: H
authors.initials: H
authors.lastname: Helenius
authors.forename: E
authors.initials: E
authors.lastname: Salminen
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood* / Q000201:enzymology / Q000556:secondary*; D001943:Breast Neoplasms / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D024042:Collagen Type I; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides; D011347:Procollagen / Q000097:blood*; D012680:Sensitivity and Specificity; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D014408:Biomarkers, Tumor; D024042:Collagen Type I; D007527:Isoenzymes; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; D000469:Alkaline Phosphatase; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase