[Experimental study of acellular xenogenic dermal matrix and allogeneic sclera as wrapping materials for hydroxy apatite implantation].
OBJECTIVE
To observe the experimental results and histopathological changes of acellular xenogenic dermal matrix (X-ADM) and allogeneic sclera used as wrapping materials of hydroxy apatite (HA) ocular implants in New Zealand white rabbits.


METHODS
Twenty-four rabbits received unilateral eye enucleating and the sockets were implanted with HA spherical implants wrapped with either acellular xenogenic dermal matrix or allogeneic sclera at random. The rabbits were examined for inflammation and implant exposure and sacrificed at 1, 2, 4, 6, 8 and 12 weeks after implantation. The sockets with the grafts were exenterated and the specimens were assessed histopathologically and ultrastructurally with light or transmission electron microscopy for the changes in inflammation reaction and vascularization.


RESULTS
Compared to allogeneic sclera at the same stage of implantation, acellular xenogenic dermal matrix demonstrated more active and earlier growth of fibroblasts and new vessels with abundant collagen deposition. There were few inflammatory cells and no rejection was found.


CONCLUSIONS
This experiment showed that the acellular xenogenic dermal matrix, with fast neovascularization and low immunity, can be an ideal material of ocular implant and a good substitute for allogeneic sclera.
He
Zhao-yan
ZY
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.
Hui
Yan-nian
YN
Han
Quan-hong
QH
Wang
Lin
L
Zhang
Zi-feng
ZF
Han
Jing
J
D000818:Animals; D020405:Dermis / Q000637:transplantation*; D005137:Eye, Artificial; D005260:Female; D006882:Hydroxyapatites; D008297:Male; D011817:Rabbits; D012590:Sclera / Q000637:transplantation*; D013552:Swine; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D006882:Hydroxyapatites