title: Neuroprotective effect of PACAP against kainic acid-induced neurotoxicity in rat retina.
abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion cells in the retina died after KA injection in the control group and PACAP treatment significantly promoted cell survival. These findings strongly suggest that PACAP plays very important roles in preventing cell death in the retina.
authors.affiliation: Department of Ophthalmology, Kozawa Eye Hospital Eye Research Center, 2-2-11 Gokencho, Mito, Ibaraki 3100063, Japan. t.seki@kozawa-ganka.or.jp
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Seki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nakatani
authors.forename: Chisato
authors.initials: C
authors.lastname: Taki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Motoki
authors.initials: M
authors.lastname: Ozawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Seiji
authors.initials: S
authors.lastname: Shioda
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D007608:Kainic Acid / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000187:drug effects*
chemical_list: D018696:Neuroprotective Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D007608:Kainic Acid