title: Effects of risperidone on auditory information processing in neuroleptic-naive patients with schizophrenia spectrum disorders.
abstract: Early effects of risperidone (2.5 +/- 1 mg/day) on auditory information processing were investigated in 9 neuroleptic naive patients with schizophrenia spectrum disorders and 9 healthy controls by using event-related potentials (ERPs). ERPs were elicited during active auditory "oddball" paradigm and were recorded before and after two weeks of treatment. Baseline P3 latencies were significantly delayed in patient group. Risperidone treatment did not change P3 amplitudes and latencies. However, P2 amplitudes were reduced in parallel with the clinical improvement measured by Positive and Negative Syndrome Scale (PANSS). Although risperidone did not change neural bases of active attention after two weeks of treatment, the reduction of P2 amplitude suggests that risperidone may affect auditory information processing in patients with schizophrenia spectrum disorders who never have been exposed to antipsychotic treatment.
authors.affiliation: Department of Electrophysiology, Republican Vilnius Psychiatric Hospital, Parko-15, Vilnius, Lithuania LT-11205. milena@rvpl.lt.
authors.forename: Milena
authors.initials: M
authors.lastname: Korostenskaja
authors.forename: Kastysis
authors.initials: K
authors.lastname: Dapsys
authors.forename: Aldona
authors.initials: A
authors.lastname: Siurkute
authors.forename: Valentinas
authors.initials: V
authors.lastname: Maciulis
authors.forename: Osvaldas
authors.initials: O
authors.lastname: Ruksenas
authors.forename: Seppo
authors.initials: S
authors.lastname: Kähkönen
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001288:Attention / Q000187:drug effects; D001307:Auditory Perception / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D018967:Risperidone / Q000008:administration & dosage*; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone