title: Can Asperger syndrome be diagnosed at 26 months old? A genetic high-risk single-case study.
abstract: Asperger syndrome, a heritable condition entailing empathy deficits together with unusually narrow interests in individuals of normal or even above-average intelligence, was recognized only recently. Here we report the first-ever prospective study of a child born to two adults with a formal diagnosis of Asperger syndrome. The child's parents are both scientists (a mathematician and a chemist). The aim of study 1 was to test if the child also developed Asperger syndrome, given the heritability of the condition, and if Asperger syndrome can be detected at 26 months. At 18 months, the child was given the Checklist for Autism in Toddlers, and at 26 months, she was assessed diagnostically for autism spectrum conditions using the Autism Diagnostic Interview-Revised and the Autism Diagnostic Observational Scale. The child failed the Checklist for Autism in Toddlers at 18 months and met the criteria for Asperger syndrome at 26 months. This single case is consistent with the hypersystemizing, assortative mating theory of autism. This theory requires further testing with large samples. This study also demonstrates that Asperger syndrome can be diagnosed by age 26 months. The aim of study 2 was to test if dyadic eye contact in infancy is intact in a child later diagnosed with Asperger syndrome. The same child's eye contact was measured at three time points (3, 6, and 9 months) over her first year of life and compared with that of age-matched controls. Although the child had low rates of eye contact at 6 months, it was within the normal range at all three points in the first year of life. We conclude that low levels of eye contact are not predictive of later development of Asperger syndrome.
authors.affiliation: Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. sb205@cam.ac.uk
authors.forename: Simon
authors.initials: S
authors.lastname: Baron-Cohen
authors.forename: Fiona
authors.initials: F
authors.lastname: Scott
authors.forename: Sally
authors.initials: S
authors.lastname: Wheelwright
authors.forename: Mark
authors.initials: M
authors.lastname: Johnson
authors.forename: Dheraj
authors.initials: D
authors.lastname: Bisarya
authors.forename: Atman
authors.initials: A
authors.lastname: Desai
authors.forename: Jag
authors.initials: J
authors.lastname: Ahluwalia
mesh_terms: D000367:Age Factors; D020817:Asperger Syndrome / Q000175:diagnosis* / Q000235:genetics*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005403:Fixation, Ocular; D006801:Humans; D007223:Infant; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012307:Risk Factors; D014743:Videotape Recording