title: Boronated thymidine analogues for boron neutron capture therapy.
abstract: Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.
authors.affiliation: College of Pharmacy, The Ohio State University, Columbus, Ohio 43120, USA.
authors.forename: B T S
authors.initials: BT
authors.lastname: Thirumamagal
authors.forename: Jayaseharan
authors.initials: J
authors.lastname: Johnsamuel
authors.forename: Guirec Y
authors.initials: GY
authors.lastname: Cosquer
authors.forename: Youngjoo
authors.initials: Y
authors.lastname: Byun
authors.forename: Junhua
authors.initials: J
authors.lastname: Yan
authors.forename: Sureshbabu
authors.initials: S
authors.lastname: Narayanasamy
authors.forename: Werner
authors.initials: W
authors.lastname: Tjarks
authors.forename: Rolf F
authors.initials: RF
authors.lastname: Barth
authors.forename: Ashraf S
authors.initials: AS
authors.lastname: Al-Madhoun
authors.forename: Staffan
authors.initials: S
authors.lastname: Eriksson
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D016754:Boron Neutron Capture Therapy; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D010766:Phosphorylation; D013936:Thymidine / Q000031:analogs & derivatives*; D013937:Thymidine Kinase / Q000378:metabolism
chemical_list: D001896:Boron Compounds; D013937:Thymidine Kinase; C092717:thymidine kinase 1; D013936:Thymidine