title: Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents.
abstract: We describe a novel class of benzocycloheptanone derived oxazolidinone antibacterial agents. The synthesis and antibacterial activities with structure variation is discussed.
authors.affiliation: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. Josyula.VaraPrasad@Pfizer.com
authors.forename: J V N
authors.initials: JV
authors.lastname: Vara Prasad
authors.forename: Frederick E
authors.initials: FE
authors.lastname: Boyer
authors.forename: Lou
authors.initials: L
authors.lastname: Chupak
authors.forename: Michael
authors.initials: M
authors.lastname: Dermyer
authors.forename: Qizhu
authors.initials: Q
authors.lastname: Ding
authors.forename: K
authors.initials: K
authors.lastname: Gavardinas
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hagen
authors.forename: Michael D
authors.initials: MD
authors.lastname: Huband
authors.forename: Wenhua
authors.initials: W
authors.lastname: Jiao
authors.forename: Takushi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Samarendra N
authors.initials: SN
authors.lastname: Maiti
authors.forename: Michael
authors.initials: M
authors.lastname: Melnick
authors.forename: Karina
authors.initials: K
authors.lastname: Romero
authors.forename: M
authors.initials: M
authors.lastname: Patterson
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Wu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001567:Benzocycloheptenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001567:Benzocycloheptenes; D023303:Oxazolidinones