title: A regioselective cyanohydration of steroidal 17-ketones and the configuration of the resulted cyanohydrins.
abstract: Cyanohydration of some 17-keto steroids with 4-en-3-one or 1,4-dien-3-one unit showed high regioselectivity to give 17-cyanohydrins with high yields when the reaction was carried out under acetone cyanohydrin/K2CO3 in aq. MeOH. The crystal X-ray exhibited the configuration of resulted cyanohydrins were depended on the structure of substrates.
authors.affiliation: Department of Medicinal Chemistry, Pharmacy School, Fudan University, Shanghai 200032, China.
authors.forename: Bei Na
authors.initials: BN
authors.lastname: Zhang
authors.forename: Min Qin
authors.initials: MQ
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Xia
mesh_terms: D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D007659:Ketones; D009570:Nitriles; D013256:Steroids; C430593:cyanohydrin