Interleukin-1beta as a mechanism for stress-induced startle suppression in females.
Startle measures were taken 2 h following a systemic injection of interleukin-1beta (IL-1beta) (3 microg/kg) to intact or ovariectomy (OVX) female rats. Changes in startle responsivity (reduced startle magnitude) were evident in intact IL-1beta-treated rats, despite no significant effects on startle sensitivity (number of elicited startles). No significant changes in startle sensitivity or responsivity were evident in IL-1beta-treated OVX rats. These results are discussed as a possible mechanism for stress-induced suppression of startle responsivity seen in intact female rats.
Beck
Kevin D
KD
Neurobehavioral Research Laboratory (129), East Orange VA Medical Center, 385 Tremont Ave., East Orange, NJ 07018, USA. beck@njneuromed.org
Servatius
Richard J
RJ
D000818:Animals; D005260:Female; D007375:Interleukin-1 / Q000494:pharmacology*; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013216:Reflex, Startle / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*
D007375:Interleukin-1