A corrected Haldane's map function to calculate genetic distances from recombination data.
The estimation of genetic distances from recombination data has no direct relationship due to the fact that multiple crossovers do not generate recombinant gametes that can be recognized in the progeny. The Haldane's map function is the most widely used mathematical formulation able to relate the observed recombination frequency with the actual number of crossovers. Here I show that the model in which the Haldane's correction is based on is not correct, and I present a modified map function that takes into consideration the actual number of recombinant gametes produced in cells in which different number of crossovers have occurred. My correction generates shorter genetic distances than the Haldane's one.
Casares
Pelayo
P
Area de Genetica, Facultad de Medicina, Biologia Funcional, Universidad de Oviedo, Julian Claveria s/n, Oviedo, Spain. pcg@uniovi.es
D002874:Chromosome Mapping / Q000379:methods*; D003434:Crossing Over, Genetic / Q000235:genetics*; D008957:Models, Genetic; D011995:Recombination, Genetic / Q000235:genetics*