title: [Damage of iron metabolism and oxidoreduction process in children with beta-thalassemia].
abstract: beta-thalassemia is the most common monogenic hereditary blood disease in children. It is also considered to be the regional pathology for Georgia. The influence of iron metabolism disorder on metabolic processes taking place in erythrocyte membrane and their role in pathogenesis of beta-thalassemia, is very important until now. The aim of our research was to study the condition of oxidoreduction processes in RBC membranes on the background of iron metabolism disorder in children with beta-thalassemia. We observed 44 patients with beta-thalassemia aged 0.4-14 years. Iron, ferritin, malon-dialdehyde and catalase were evaluated. The carried out investigation revealed, that oxidoreduction processes in patients with beta-thalassemia, together with iron overload, is one of the factors in promoting further disorder of proliferation and differentiation processes in erythrone system and also in formation of ineffective erythropoiesis. The revealed changes in data of iron metabolism. malon-dialdehyde and catalase showed us the need for correction of this disorder. Pathogenetically there are good reasons to include in the combined treatment beta-thalassemia the membrano-protective preparations (vitamin E, acetylcysteine) together with the hemotransfusion and chelator therapy.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Mtvarelidze
authors.forename: A N
authors.initials: AN
authors.lastname: Kvezereli-Kopadze
authors.forename: M N
authors.initials: MN
authors.lastname: Kvezereli-Kopadze
mesh_terms: D000293:Adolescent; D002374:Catalase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004910:Erythrocyte Membrane / Q000378:metabolism; D004920:Erythropoiesis / Q000502:physiology; D005293:Ferritins / Q000097:blood; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood*; D019189:Iron Metabolism Disorders / Q000097:blood* / Q000209:etiology; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction; D012307:Risk Factors; D012720:Severity of Illness Index; D017086:beta-Thalassemia / Q000097:blood* / Q000150:complications
chemical_list: D008315:Malondialdehyde; D005293:Ferritins; D007501:Iron; D002374:Catalase