Subacute combined degeneration of the spinal cord concomitant with gastric cancer.
We report a rare case of subacute combined degeneration of the spinal cord concomitant with gastric cancer. A 67-year-old man was admitted because of posterior column symptoms, pyramidal tract sign and peripheral neuropathy with severe hyperchromic anemia. He was treated with mecobalamin 1 mg IM, after which his anemia and neurological signs recovered. He was diagnosed as having subacute combined degeneration with pernicious anemia. Subsequent stomach biopsy revealed gastric cancer, and the patient underwent gastrectomy. It is a well known association that chronic atrophic gastritis is associated with gastric cancer or subacute combined degeneration. Our findings suggest that in this case subacute combined degeneration and gastric cancer are independent of each other; rather, both resulted from chronic atrophic gastritis.
Hirata
Ayako
A
Department of Neurology, Toho University School of Medicine, Oohashi Hospital, Tokyo.
Nomoto
Nobuatsu
N
Konno
Shingo
S
Nakazora
Hiroshi
H
Sugimoto
Hideki
H
Nemoto
Hiroshi
H
Kurihara
Teruyuki
T
Wakata
Nobuo
N
D000368:Aged; D000747:Anemia, Hypochromic / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D009410:Nerve Degeneration / Q000209:etiology* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000627:therapeutic use
C019476:mecobalamin; D014805:Vitamin B 12