[Notch signaling in chondrogenesis].
Notch is a signaling molecule which plays a critical role in the determination of multiple cellular differentiation pathways and morphogenesis in various biological systems, such as neurogenesis, immune system, and hematopoiesis. However, roles of Notch signaling in osteo/chondrogenesis have not been well studied. We will present our recent progress in investigating roles of Notch signaling in chondrogenesis using in vitro chondrogenic system. We will also discuss about the recent reports which used conditional knockout mice to investigate roles of Notch signaling molecules in vivo .
Fujimaki
Ryoji
R
Keio University School of Medicine, Department of Orthopaedic Surgery.
Tezuka
Ken-ichi
K
D000818:Animals; D002478:Cells, Cultured; D020219:Chondrogenesis / Q000502:physiology*; D051379:Mice; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction
D051880:Receptors, Notch