title: Clinical features and outcome of familial chronic lymphocytic leukemia.
abstract: The prognostic impact of the presence of a familial trait was analyzed in 1449 patient with chronic lymphocytic leukemia (CLL). A family history of hematologic malignancy (HM) was identified in 181 cases (12.5%) and recorded more frequently among female than male patients (HM: p < 0.05; CLL: p < 0.05). The relative was affected by CLL in 89 cases (6%). Familial and sporadic cases showed non-statistically different proportions of advanced stages (10.8 vs 7.1%) and patients requiring therapy (55 vs 60%) and a similar survival probability at 10 years (67 vs 66%). These data suggest that in CLL the presence of a familial trait does not imply an adverse prognosis.
authors.affiliation: Division of Hematology, Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Via Benevento 6, 00161 Rome, Italy. mauro@bce.uniroma1.it
authors.forename: Francesca R
authors.initials: FR
authors.lastname: Mauro
authors.forename: Elena
authors.initials: E
authors.lastname: Giammartini
authors.forename: Massimo
authors.initials: M
authors.lastname: Gentile
authors.forename: Isabella
authors.initials: I
authors.lastname: Sperduti
authors.forename: Veronica
authors.initials: V
authors.lastname: Valle
authors.forename: Antonio
authors.initials: A
authors.lastname: Pizzuti
authors.forename: Anna
authors.initials: A
authors.lastname: Guarini
authors.forename: Diana
authors.initials: D
authors.lastname: Giannarelli
authors.forename: Robin
authors.initials: R
authors.lastname: Foà
mesh_terms: D005190:Family; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012384:Rome / Q000453:epidemiology; D012727:Sex Characteristics; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome