The clot thickens.
Vascular sclerosis has been linked to many risk factors, including smoking, family history, low birth weight, and hypertension. In interesting studies, Goforth et al. show an increased rate of mutations in thrombophilic molecules in patients with vascular sclerosis in renal biopsies, suggesting yet another mechanism.
Fogo
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Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. agnes.fogo@vanderbilt.edu
D001706:Biopsy; D003920:Diabetes Mellitus / Q000235:genetics / Q000503:physiopathology; D005165:Factor V / Q000235:genetics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics / Q000502:physiology; D009154:Mutation; D009400:Nephrosclerosis / Q000209:etiology* / Q000235:genetics* / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics / Q000502:physiology; D011516:Prothrombin / Q000235:genetics / Q000502:physiology; D012077:Renal Artery / Q000473:pathology* / Q000503:physiopathology; D012307:Risk Factors; D012598:Sclerosis / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects
D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)