Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way.
The possibility for the application of organic synthesis to the discovery of new agents in combating neurodegenerative disorders is described. Our focus has been on agents derived from natural-product leads and natural products themselves prepared through total synthesis. Herein, we describe some of the chemistry as well as interesting observations made along the way.
Wilson
Rebecca M
RM
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
Danishefsky
Samuel J
SJ
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry; D004149:Dioxoles / Q000138:chemical synthesis / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry
C516856:11-O-debenzoyltashironin; D001688:Biological Products; D001952:Bridged-Ring Compounds; D004149:Dioxoles; D004224:Diterpenes; D007783:Lactones; C466781:NGA 0187; D012717:Sesquiterpenes; D013729:Terpenes; D014315:Triterpenes; C106690:garsubellin A; C457979:jiadifenin; C458341:merrilactone A; C119787:scabronine G; C098157:tricycloillicinone