[Changes of IFN-gamma, IL-2, IL-6 and IL-10 in the patient with cardiac surgery under combined acupuncture anesthesia].
OBJECTIVE
To observe the effect of electroacupuncture (EA) on cytokines in the cardiac surgical patient and to evaluate the application of combined acupuncture anesthesia to cardiac surgery.


METHODS
Thirty patients with atrial septal defect were divided into 3 groups, general anesthesia group (A), acupuncture anesthesia group (B) and combined general anesthesia and EA group (C). Peripheral blood samples were collected before anesthesia, before cardiopulmonary bypass (CPB), 30 min after CPB and 24 h after operation to determine the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), IL-6 and IL-10.


RESULTS
The levels of IFN-gamma and IL-2 decreased in the 3 groups after CPB and further decreased 24 h after operation, and in the group C were higher than those in the group B. The levels of IL-6 and IL-10 significantly increased 24 h after operation in the 3 groups with no significant difference among the 3 groups.


CONCLUSIONS
The general anesthesia combined with EA can not completely improve the decrease of IFN-gamma and IL-2 induced by CPB, indicating that the good response of the general anesthesia combined with EA to stress can partially improve the immunosupression induced by CPB. Acupuncture does not have significant effect on inflammatory cytokine reaction induced by cardiac surgery.
Yang
Qing-guo
QG
Beijing Jishuitan Hospital, Beijing, China. yang_qingguo@hotmail.com
Hang
Yan-nan
YN
Sun
Da-jin
DJ
Chen
Xi-ming
XM
Wang
Xiang-rui
XR
Xu
Can-ran
CR
Yao
Jian-ling
JL
D015667:Acupuncture Analgesia; D000328:Adult; D006348:Cardiac Surgical Procedures; D015671:Electroacupuncture; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged
D007376:Interleukin-2; D015850:Interleukin-6; D016753:Interleukin-10; D007371:Interferon-gamma