title: Lethal brain abscess due to the fungus Scedosporium apiospermum (teleomorph Pseudallescheria boydii) after a near-drowning incident: case report and review of the literature.
abstract: A 39-year-old healthy man developed a brain abscess weeks after a near-drowning incident. Scedosporium apiospermum, the anamorph of Pseudallescheria boydii, was isolated from the abscess. The patient died 153 days after the accident despite antifungal therapy. We discuss the role of antifungals and review the literature for comparable cases.
authors.affiliation: Medical Mycology, Institute of Hygiene, Medical University Graz, Universitaetsplatz, Graz, Austria. walter.buzina@meduni-graz.at
authors.forename: W
authors.initials: W
authors.lastname: Buzina
authors.forename: G
authors.initials: G
authors.lastname: Feierl
authors.forename: D
authors.initials: D
authors.lastname: Haas
authors.forename: F F
authors.initials: FF
authors.lastname: Reinthaler
authors.forename: A
authors.initials: A
authors.lastname: Holl
authors.forename: R
authors.initials: R
authors.lastname: Kleinert
authors.forename: B
authors.initials: B
authors.lastname: Reichenpfader
authors.forename: P
authors.initials: P
authors.lastname: Roll
authors.forename: E
authors.initials: E
authors.lastname: Marth
mesh_terms: D000063:Accidents, Traffic; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D001922:Brain Abscess / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D008271:Mycetoma / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D015701:Near Drowning / Q000150:complications*; D011541:Pseudallescheria / Q000302:isolation & purification; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D021681:Scedosporium / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D013687:Telencephalon / Q000382:microbiology; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole