title: Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease.
abstract: Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant stimulation parameters resulted in a significant improvement of cognitive dysfunction and reduced the number of choreiform movements. This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD.
authors.affiliation: Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands. y.temel@np.unimaas.nl
authors.forename: Yasin
authors.initials: Y
authors.lastname: Temel
authors.forename: Chunyan
authors.initials: C
authors.lastname: Cao
authors.forename: Rinske
authors.initials: R
authors.lastname: Vlamings
authors.forename: Arjan
authors.initials: A
authors.lastname: Blokland
authors.forename: Hatice
authors.initials: H
authors.lastname: Ozen
authors.forename: Harry W M
authors.initials: HW
authors.lastname: Steinbusch
authors.forename: Kimmo A
authors.initials: KA
authors.lastname: Michelsen
authors.forename: Stephan
authors.initials: S
authors.lastname: von Hörsten
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmitz
authors.forename: Veerle
authors.initials: V
authors.lastname: Visser-Vandewalle
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D046690:Deep Brain Stimulation / Q000379:methods* / Q000592:standards; D004195:Disease Models, Animal; D005917:Globus Pallidus / Q000503:physiopathology*; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D009068:Movement / Q000502:physiology; D009154:Mutation; D017072:Neostriatum / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000235:genetics; D009434:Neural Pathways / Q000503:physiopathology*; D009687:Nuclear Proteins / Q000235:genetics; D051381:Rats; D020127:Recovery of Function; D016896:Treatment Outcome
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins