title: Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
abstract: A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università di Siena, via Aldo Moro, 53100 Siena, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Gemma
authors.forename: Gagan
authors.initials: G
authors.lastname: Kukreja
authors.forename: Caterina
authors.initials: C
authors.lastname: Fattorusso
authors.forename: Marco
authors.initials: M
authors.lastname: Persico
authors.forename: Maria P
authors.initials: MP
authors.lastname: Romano
authors.forename: Maria
authors.initials: M
authors.lastname: Altarelli
authors.forename: Luisa
authors.initials: L
authors.lastname: Savini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Campiani
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Basilico
authors.forename: Donatella
authors.initials: D
authors.lastname: Taramelli
authors.forename: Vanessa
authors.initials: V
authors.lastname: Yardley
authors.forename: Stefania
authors.initials: S
authors.lastname: Butini
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D006835:Hydrazones; D002738:Chloroquine