title: MicroRNAs: expression, avoidance and subversion by vertebrate viruses.
abstract: MicroRNAs (miRNAs), which can be expressed in a cell-type and tissue-specific manner, can influence the activities of genes that control cell growth and differentiation. Viruses often have clear tissue tropisms, raising the possibility that cellular miRNAs might modulate their pathogenesis. In this Review, we discuss recent findings that some vertebrate viruses either encode miRNAs or subvert cellular miRNAs, and that these miRNAs participate in both the infectious and the latent phase of the viral life cycle.
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94301, USA. psarnow@stanford.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Sarnow
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Jopling
authors.forename: Kara L
authors.initials: KL
authors.lastname: Norman
authors.forename: Sylvia
authors.initials: S
authors.lastname: Schütz
authors.forename: Karen A
authors.initials: KA
authors.lastname: Wehner
mesh_terms: D000818:Animals; D004267:DNA Viruses / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D015536:Down-Regulation; D016679:Genome, Viral; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D015854:Up-Regulation; D014714:Vertebrates / Q000821:virology
chemical_list: D035683:MicroRNAs