Plasmapheresis for recurrent posttransplant focal segmental glomerulosclerosis.
The high recurrence rate of focal segmental glomerulosclerosis (FSGS) in kidney transplant recipients suggests that such patients have a circulating factor that alters glomerular capillary permeability. Serum from patients with FSGS increases glomerular permeability to albumin. This permeability factor has been partially identified as a protein. The removal of this protein by plasmapheresis (PP) decreases proteinuria. In this study we report data on the therapeutic effects of PP in FSGS children with recurrence in the transplanted kidney. Three hundred pediatric (age <19 years) renal transplants were performed, including 21 patients (24 transplants) with FSGS as a cause of renal failure. Fourteen (58.3%) subjects experienced disease recurrence (proteinuria >1 g/m(2) per day) within 1 month after transplantation. Mean age patient was 12 +/- 4.3 years, including 83.3% Caucasians and 70.2% recipients of living donor grafts. Nine were treated with 10 cycles of PP (3 cycles/weekly), initiated immediately after recurrence (<48 hours). Immunosuppression included high doses of cyclosporine (C(2) levels of 1700-1800 ng/mL), mycophenolate sodium or mofetil, and prednisone. Thirteen patients were induced with anti-IL2 receptor monoclonal antibody (daclizumab/basiliximab). Among the patients who underwent PP, five (55.5%) achieved a complete remission and one (12%), a partial remission (1 g/24 hours). There were no cases of remission among the five patients who were not treated with PP. Those who achieved remission after PP experienced no recurrences during the 2.6 +/- 1.4 years follow-up. PP appears to be effective to treat recurrent FSGS following kidney transplantation. It should be started as soon as possible.
Garcia
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CD
Santo Antônio Children's Hospital, Santa Casa Hospital Complex, School of Medical Sciences of Porto Alegre, Correa Lima 1493, Porto Alegre, 90850-250 Brazil. cdgarcia1@uol.com.br
Bittencourt
V B
VB
Tumelero
A
A
Antonello
J S
JS
Malheiros
D
D
Garcia
V D
VD
D000293:Adolescent; D000328:Adult; D002648:Child; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007501:Iron / Q000097:blood; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D010956:Plasmapheresis; D011183:Postoperative Complications / Q000628:therapy; D012008:Recurrence
D007501:Iron