title: Ovarian interstitial YAG-laser: an effective new method to manage anovulation in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  This study was undertaken to assess the effectiveness of transvaginal ultrasound-guided ovarian interstitial laser-coagulation treatment in anovulatory women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Nineteen anovulatory women with clomiphene citrate-resistant PCOS underwent ultrasound-guided transvaginal ovarian interstitial YAG-laser treatment. In this study, serum hormonal level, spontaneous ovulation rate, and pregnancy rate were assessed.
  
  
  RESULTS
  With a spontaneous ovulation rate of 84.2%, 16 of 19 cases ovulated regularly during the 6-month postoperative period. The mean serums luteinizing hormone and serum testosterone levels in the second, fourth, and sixth postoperative months were significantly lower than preoperative levels: 5.87 +/- 2.04 IU/L versus 13.17 +/- 3.03 IU/L (P < .001) and 2.98 +/- 1.79 nmol/L versus 5.49 +/- 3.23 nmol/L (P < .001), respectively. The mean luteinizing hormone/follicle-stimulating hormone ratio was also significantly lower postoperatively at 1.09 +/- 0.30 compared with the preoperative 2.85 +/- 1.14 (P < .001). There was a cumulative pregnancy rate at 6 months of 32.3% (6/19) among the subjects. No significant operative complications were encountered.
  
  
  CONCLUSIONS
  The ultrasound-guided transvaginal ovarian interstitial laser treatment may be an effective new method to manage anovulation in PCOS patients.
authors.affiliation: Department of Reproductive Health, ShenZhen Maternity and Child Healthcare Hospital, ShenZhen, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhu
authors.forename: Xuemei
authors.initials: X
authors.lastname: Li
authors.forename: Xiumin
authors.initials: X
authors.lastname: Chen
authors.forename: Zhan
authors.initials: Z
authors.lastname: Lin
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000535:Aluminum; D000858:Anovulation / Q000209:etiology / Q000601:surgery*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D017075:Laser Coagulation; D007834:Lasers; D007986:Luteinizing Hormone / Q000097:blood; D006080:Ovarian Follicle / Q000166:cytology; D010053:Ovary / Q000000981:diagnostic imaging; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000601:surgery*; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography; D014621:Vagina / Q000000981:diagnostic imaging; D015019:Yttrium
chemical_list: C503779:yttrium-aluminum-garnet; D013739:Testosterone; D015019:Yttrium; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000535:Aluminum