title: Allosteric regulation of the conformational dynamics of a cavitand receptor.
abstract: [reaction: see text] Inspired by allostery in nature, we synthesized cavitand 1 and investigated regulation of its conformational dynamics. Quantitative 1H NMR studies have revealed that the rate of the conformational isomerization of 1 can be modulated using the external addition of acid. As 1 maintains its vase-like conformation in an acidic environment, ample opportunities for controlling the kinetics of molecular recognition, and thus reactivity, in this and related receptors have arisen.
authors.affiliation: Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Yan
authors.forename: Yuning
authors.initials: Y
authors.lastname: Chang
authors.forename: Dennis
authors.initials: D
authors.lastname: Mayo
authors.forename: Veselin
authors.initials: V
authors.lastname: Maslak
authors.forename: Shijing
authors.initials: S
authors.lastname: Xia
authors.forename: Jovica D
authors.initials: JD
authors.lastname: Badjić