title: Influence of smoking on osseointegrated implant failure: a meta-analysis.
abstract: The aim of this study was to examine the influence of smoking on osseointegrated implant failure by performing a meta-analysis. A computerized literature search using PubMed database (in English) and Japana Centra Revuo Medicina (in Japanese) was carried out to identify all relevant studies. Among 175 studies identified and chosen for detailed review, 19 were appropriate for inclusion in our meta-analysis. When smokers were compared with non-smokers, odds ratio (OR) for osseointegrated implant failure was significantly elevated (OR 2.17, 95% confidence intervals (CI), 1.67-2.83). Seven studies were appropriate to examine the influence of intra-oral location (maxillary arch vs. mandibular arch) of implant failure on smoking. The OR for implant failure occurring in the maxillary arch was significantly elevated (OR 2.06, 95% CI, 1.61-2.65), whereas the OR in the mandibular arch did not demonstrate a significant increased risk associated with smoking (OR 1.32, 95% CI, 0.72-2.4). Our meta-analysis revealed a significant relationship between smoking and the risk of osseointegrated implant failure, more particularly those implants located in the maxillary arch.
authors.affiliation: Department of Preventive Dentistry, Institute of Health Bioscience, The University of Tokushima Graduate School, and Department of Oral and Maxillofacial Surgery, Tokushima University Hospital, Tokushima City, Japan. hinode@dent.tokushima-u.ac.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hinode
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Tanabe
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Fujisawa
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamauchi
authors.forename: Youji
authors.initials: Y
authors.lastname: Miyamoto
mesh_terms: D003724:Dental Arch; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019232:Dental Restoration Failure; D004812:Epidemiologic Methods; D006801:Humans; D008334:Mandible; D008437:Maxilla; D012907:Smoking / Q000009:adverse effects*
chemical_list: D015921:Dental Implants