Novel antitumor and radioprotective sulfonamides containing pyrrolo [2,3-d]pyrimidines.
Several sulfonamides having pyrrole (5a-c, 8, 11b-19, 23, 24), pyrrolo[2,3-d] pyrimidine (6, 7, 10, 20, 21, 25) and pyrrolo[2,3-b]pyridine (22) were synthesized and evaluated for their antitumor and radioprotective activities. The structure of the synthesized compounds was elucidated by elemental analyses and spectral data. Compounds 5a, 16, 17, 19, and 23 displayed more potent antitumor activities than the reference drug, doxorubicin. On the other hand compounds 19, 23 and 25 exhibited radioprotective activities.
Ghorab
Moustafa M
MM
Department of Drug Radiation Research, National Centre for Radiation Research and Technology, P.O. Box 29, Nasr City, Cairo, Egypt. ghorabmoustafa@yahoo.com
Noaman
Eman
E
Ismail
Magda M F
MM
Heiba
Helmy I
HI
Ammar
Yousry A
YA
Sayed
Marwa Y
MY
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D045744:Cell Line, Tumor; D005260:Female; D005720:Gamma Rays; D005978:Glutathione / Q000097:blood; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009368:Neoplasm Transplantation; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood
D000970:Antineoplastic Agents; D000975:Antioxidants; D007202:Indicators and Reagents; D011743:Pyrimidines; D011758:Pyrroles; D011837:Radiation-Protective Agents; D013449:Sulfonamides; D013482:Superoxide Dismutase; D005978:Glutathione