title: Diphenylphosphinoyl-mediated synthesis of ketones.
abstract: alpha-Diphenylphosphinoyl ketones are selectively and sequentially alkylated at the alpha-position. Double lithiation and selective alkylation occurs at the less stabilised gamma-position. Dephosphinoylation of the alkylation products gives ketones. Mono-alkylation is selective, highly crystalline intermediates are formed and a one-pot strategy is possible. The method is ideally suited for the preparation of acid-sensitive ketones.
authors.affiliation: Cambridge University, University Chemical Laboratory, Lensfield Road, Cambridge, UK. dif34@cam.ac.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Fox
authors.forename: Daniel Sejer
authors.initials: DS
authors.lastname: Pedersen
authors.forename: Stuart
authors.initials: S
authors.lastname: Warren