title: Estrogen-receptor-alpha-positive extramammary Paget's disease treated with hormonal therapy.
abstract: The patient was an 80-year-old man with scrotal and penile extramammary Paget's disease and prostate cancer. Both diseases were in advanced stages. Tumor cells of extramammary Paget's disease strongly expressed estrogen receptor alpha. The patient was concurrently treated with two kinds of hormonal therapy: the anti-estrogen tamoxifen (20 mg/day orally) for extramammary Paget's disease and the anti-androgen bicalutamide (80 mg/day orally) for prostate cancer. The toxicity of the therapy was mild. All of the metastatic lesions remained stable for 2 months after initiation of dual hormonal therapy. During a follow-up period of 22 months, performance status was well maintained for 17 months. Hormonal therapy may be an alternative for selected cases of advanced extramammary Paget's disease.
authors.affiliation: Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan. miwakoki33@yahoo.co.jp
authors.forename: M
authors.initials: M
authors.lastname: Iijima
authors.forename: H
authors.initials: H
authors.lastname: Uhara
authors.forename: Y
authors.initials: Y
authors.lastname: Ide
authors.forename: S
authors.initials: S
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Onuma
authors.forename: M
authors.initials: M
authors.lastname: Muto
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: F
authors.initials: F
authors.lastname: Mitsura
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Yoshizawa
authors.forename: T
authors.initials: T
authors.lastname: Saida
mesh_terms: D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000813:Anilides / Q000627:therapeutic use*; D001706:Biopsy; D003937:Diagnosis, Differential; D047628:Estrogen Receptor alpha / Q000097:blood*; D017809:Fatal Outcome; D005500:Follow-Up Studies; D005834:Genital Neoplasms, Male / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D009570:Nitriles; D010145:Paget Disease, Extramammary / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D014105:Tosyl Compounds
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D047628:Estrogen Receptor alpha; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide