A splice variant to PACAP receptor that is involved in spermatogenesis is expressed in astrocytes.
The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor, PAC1, recognizes PACAP with a higher affinity than it recognizes vasoactive intestinal peptide (VIP) and belongs to the subfamily G protein-coupled receptors. So far, more than 10 different splice variants of PAC1 have been cloned from rat tissue. Interestingly, the various PAC1 splice variants exhibit different signaling pathways. These splice variants are suggested to play a functional role mostly in the brain as well as in the testes. The present article introduces PAC1(3a) that was originally discovered in testes as another potential regulator in rat astrocytes.
Pilzer
Inbar
I
Department of Molecular Genetics and Biochemistry, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Dr. Diana and Zelman Elton (Elbaum) Laboratory for Molecular Neuroendocrinology, Tel Aviv University, Tel Aviv 69978, Israel.
Gozes
Illana
I
D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000378:metabolism*; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D005091:Exons / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D012326:RNA Splicing / Q000235:genetics*; D051381:Rats; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I / Q000235:genetics*; D013091:Spermatogenesis / Q000235:genetics*
D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I