Antinociceptive effect of Hyptis pectinata leaves extracts.
Oral administration of hexanes, chloroform, and ethyl acetate extracts of the leaves of Hyptis pectinata significantly reduced the number of writhing induced by acetic acid and increased the response to thermal stimuli in hot-plate test. Such effect was completely reversed by the opioid antagonist naloxone.
Lisboa
Ana C C D
AC
Physiology Department, Federal University of Sergipe, São Cristovão, Sergipe, Brazil. tlemos@ufc.br
Mello
Iderjane C M
IC
Nunes
Rogeria S
RS
Dos Santos
Marquês A
MA
Antoniolli
Angelo R
AR
Marçal
Rosilene M
RM
Cavalcanti
Sócrates C de H
SC
D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D031331:Hyptis; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid