title: Community exposure to perfluorooctanoate: relationships between serum levels and certain health parameters.
abstract: OBJECTIVE
  The objective of this study was to determine whether certain biomarkers of toxicity and/or a past diagnosis of liver or thyroid disease were associated with serum perfluorooctanoate concentrations (PFOA) in a community with longstanding environmental exposure to PFOA.
  
  
  METHODS
  Serum (PFOA), hematologic and biochemical biomarkers, and a questionnaire were administered to 371 residents selected by stratified random sampling and a lottery among volunteers. Median PFOA was 354 ng/mL (interquartile range, 181-571 ng/mL).
  
  
  RESULTS
  No significant positive relationships between serum (PFOA) and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts. Mean serum (PFOA) was not increased in those with a history of liver or thyroid disease.
  
  
  CONCLUSIONS
  No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.
authors.affiliation: University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104-4284, USA. emmetted@mail.med.upenn.edu
authors.forename: Edward Anthony
authors.initials: EA
authors.lastname: Emmett
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Frances Susan
authors.initials: FS
authors.lastname: Shofer
authors.forename: David
authors.initials: D
authors.lastname: Freeman
authors.forename: Nancy Virginia
authors.initials: NV
authors.lastname: Rodway
authors.forename: Chintan
authors.initials: C
authors.lastname: Desai
authors.forename: Leslie Michael
authors.initials: LM
authors.lastname: Shaw
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002210:Caprylates / Q000097:blood* / Q000506:poisoning; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods; D004785:Environmental Pollutants / Q000097:blood* / Q000506:poisoning; D005260:Female; D005466:Fluorocarbons / Q000097:blood* / Q000506:poisoning; D006304:Health Status; D006801:Humans; D008107:Liver Diseases / Q000097:blood; D008297:Male; D008875:Middle Aged; D012111:Residence Characteristics; D013959:Thyroid Diseases / Q000097:blood; D014903:West Virginia
chemical_list: D002210:Caprylates; D004785:Environmental Pollutants; D005466:Fluorocarbons; C023036:perfluorooctanoic acid