Postnatal growth, neurodevelopment and altered adiposity after preterm birth--from a clinical nutrition perspective.
Evidence reveals a dilemma that under-nutrition and growth retardation during brain growth are associated with neurodevelopmental deficits, and nutritional supplement resulting in catch-up growth and relative visceral adiposity leads to metabolic/cardiovascular morbidities. Hyperinsulinaemia secondary to insulin resistance appears to play a central role in the development of visceral adiposity through its action on adipocyte beta3-adrenoceptor.


CONCLUSIONS
Optimal nutritional management to minimize hyperinsulinaemia and insulin resistance may potentially improve neurodevelopment and facilitate catch-up growth with normal body composition.
Yeung
Melinda Y
MY
Department of Pharmacy, The Children's Hospital at Westmead, New South Wales, Australia. melinday@chw.edu.au
D050154:Adiposity / Q000502:physiology*; D001921:Brain / Q000254:growth & development*; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology*; D050152:Intra-Abdominal Fat / Q000502:physiology; D024821:Metabolic Syndrome / Q000209:etiology; D022702:Receptors, Adrenergic, beta-3 / Q000502:physiology
D022702:Receptors, Adrenergic, beta-3