Treatment monitoring and response prediction with proton MR spectroscopy in AD.
In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.
Jessen
F
F
Department of Psychiatry, University of Bonn, Germany. jessen@uni-bonn.de
Traeber
F
F
Freymann
K
K
Maier
W
W
Schild
H H
HH
Block
W
W
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D003401:Creatine / Q000378:metabolism*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018670:Monitoring, Ambulatory; D011522:Protons
D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine