[Diabetic vascular calcification and abnormal bone metabolism: the relation between bone and vascular].
High-frequency severe atherosclerosis/calcinosis is observed in diabetes mellitus and chronic dialysis, which leads to cardiovascular events. However, the effective treatment for suppressing the progression of vascular calcification has not been established. Here we review the mechanism of vascular calcification and present our findings that a first generation of bisphosphonate is useful in prevention of vascular calcification in diabetes and chronic renal failure.
Okada
Yosuke
Y
University of Occupational and Environmental Health, First Department of Internal Medicine.
Nishida
Keiko
K
Tanikawa
Takahisa
T
Hashimoto
Osamu
O
Tanaka
Yoshiya
Y
D001161:Arteriosclerosis / Q000473:pathology; D001842:Bone and Bones / Q000378:metabolism*; D002114:Calcinosis; D003925:Diabetic Angiopathies / Q000473:pathology*; D006801:Humans