[Eosinophils in nasal polyposis pathogenia. Bibliographic revision].
The aim of this work is to do a review on relations between the eosinophils and nasosinusal polyps. The etiopathogenical action of eosinophils are reviewed, from bone narrow to nasal mucosa infiltration. The mechanism of tissue eosinophilic mediated inflammation, his regulation and the significance of the balance between positive (IL-5) and negative (TGFbeta and IL10) mediators are discussed. We conclude that the degree of eosinophilic infiltration and degranulation's patterns are important aspects conditioning the severity and prognosis of chronic rhinosinusitis and nasosinusal polyps.
Garín Martínez
L
L
Servicio de ORL, Hospital General Universitario, Facultad de Medicina, Valencia. lgarinm@wanadoo.es
Armengot Carceller
M
M
Carda Batalla
C
C
D015550:Cell Degranulation; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D009298:Nasal Polyps / Q000209:etiology* / Q000473:pathology*