title: The effect of 7.2% hypertonic saline solution on m-mode echocardiographic indices in normovolemic dogs.
abstract: This study investigated whether a small volume of 7.2% hypertonic saline solution (HSS) could affect M-mode echocardiographic indices in dogs. HSS induced significant increase in heart rate, stroke volume and cardiac index, when the fluid infusion was completed (P<0.05). In the HSS group, the left ventricular end-diastolic volume index, as an index of preload, significantly increased (P<0.05), whereas left ventricular end-systolic volume index were not altered. HSS induced slight increases in ejection fraction at end of infusion despite significantly differences were not observed. In conclusion, HSS did not induce a demonstrable effect on M-mode echocardiographic indices of systolic function-enhance cardiac contractility, but it caused preload augmentation that may contribute to an abrupt and transient increase in cardiac output just after HSS infusion.
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Shinobu
authors.initials: S
authors.lastname: Aoyagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koie
authors.forename: Ryuji
authors.initials: R
authors.lastname: Asano
mesh_terms: D000818:Animals; D004285:Dogs; D004452:Echocardiography / Q000379:methods*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009994:Osmolar Concentration; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects*; D013997:Time Factors
chemical_list: D012462:Saline Solution, Hypertonic