title: Mathematical simulation of dose-effect relationships for fish eggs exposed chronically to ionizing radiation.
abstract: A mathematical model which simulates the observed dose-effect relationships for fish eggs exposed to chronic irradiation is presented. The model assumes that the exposed fish eggs may exist in one of the following states: normally developing, reversibly damaged, and lethally damaged. Reversible damages may be recovered by repairing mechanisms which are spent for the repairing processes. The model was applied to describe the observed differences in effects of chronic exposure for quickly (2 weeks) and slowly (up to 20 weeks) developing fish eggs. Calculations were performed for dose rates of chronic irradiation ranging from 10 to 300 mGy/day. Two types of radiation effects were considered-the effect on eggs survival (percentage of survived eggs at time t), and the depletion of the repairing pool (in percentage of its maximal value). The model predictions have been compared with the experimental data from the EPIC database. This comparison showed that the model adequately describes the radiation effects in fish eggs of different species, within a wide range of chronic radiation exposures.
authors.affiliation: Scientific and Production Association Typhoon, 82 Lenin Ave., Obninsk, Kaluga Region 249038, Russia. ecomod@obninsk.com
authors.forename: A I
authors.initials: AI
authors.lastname: Kryshev
authors.forename: T G
authors.initials: TG
authors.lastname: Sazykina
authors.forename: K D
authors.initials: KD
authors.lastname: Badalian
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D005399:Fishes / Q000196:embryology* / Q000502:physiology*; D008954:Models, Biological; D010063:Ovum / Q000528:radiation effects*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000196:embryology*; D011839:Radiation, Ionizing; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors