[Comparison of inflammatory response after laparoscopic and conventional surgery for colorectal carcinoma].
OBJECTIVE
To compare the systemic and local inflammatory response after laparoscopic and conventional surgery for colorectal carcinoma.


METHODS
From April 2004 to August 2004, 51 colorectal cancer patients undergoing laparoscopic (n=25) and conventional open (n=26) colorectal resection were enrolled in the study. The general clinical data,and inflammatory response were compared between the two groups.


RESULTS
There were no significant differences in age, sex, pre-operative levels of haemoglobin and albumin, Dukes stage and surgical procedure between the two groups (P > 0.05). Laparoscopic surgery had more advantages over conventional open surgery such as incision, operating time, recovery time of bowel function, and hospitalization. On postoperative day (POD) 1, WBC count [(7.30+/- 2.62)x10(9)/L], and the serum levels of IL-10 [(19.46+/- 3.31)pg/ml] and C-reactive protein (CRP) [(2.76+/- 2.17)mg/dl] were significantly lower in laparoscopic group than those in conventional group (P< 0.05), but there were no differences on POD 4 between the two groups (P > 0.05). There were no significant differences in the volume of peritoneal drainage fluid, and levels of IL-10, TNF and CRP in it on POD 1 between the two groups, but the volume of peritoneal drainage fluid decreased significantly from POD 2, and the level of IL-10 in it was significantly lower on POD 4 in laparoscopic group than that in conventional group.


CONCLUSIONS
In early stage after operation,intra- peritoneal inflammatory response caused by laparoscopic surgery is similar to that by conventional open surgery, but systemic inflammatory response is slighter than that by conventional open surgery for colorectal carcinoma.
Mao
Zhi-hai
ZH
Department of Surgery, Ruijin Hospital, Shcool of Medicine, Shanghai Jiaotong University, Shanghai Minimally Invasive Surgery Center, Shanghai Institute of Digestive Surgery, Shanghai 200025, China. zhihaimao@163.com
Chen
Hai-zhen
HZ
Li
Jian-wen
JW
Lu
Ai-guo
AG
Wang
Ming-liang
ML
Hu
Wei-guo
WG
Zheng
Min-hua
MH
D000368:Aged; D015179:Colorectal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D007249:Inflammation; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged