title: Pyoderma gangrenosum complicated with myelodysplastic syndrome followed by rapidly progressing pyothorax-associated lymphoma: a case report.
abstract: This report describes a patient with pyoderma gangrenosum (PG) complicated with myelodysplastic syndrome (MDS) followed by rapidly progressing pyothorax-associated lymphoma (PAL). A 74-year-old man was admitted with cutaneous gangrene associated with MDS. We diagnosed him as having PG, and high-dose oral prednisolone was started. Two months after admission he developed lymphoma rapidly. The patient died in spite of radiation therapy. On autopsy, the pathological diagnosis was diffuse large cell lymphoma. Epstein-Barr virus (EBV)-encoded RNA, and EBV-encoded nuclear antigen (EBNA) were detected in lymphoma cells. This case suggested that immunosuppressive therapy might favour the clonal proliferation of EBV-infected cells.
authors.affiliation: Division of Clinical Immunology and Hematology, Department of Medicine Sapporo City General Hospital, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Goto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Notoya
authors.forename: Akio
authors.initials: A
authors.lastname: Takada
authors.forename: Masaya
authors.initials: M
authors.lastname: Mukai
mesh_terms: D000368:Aged; D016724:Empyema, Pleural / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications*; D011239:Prednisolone / Q000008:administration & dosage; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000188:drug therapy
chemical_list: D011239:Prednisolone