Carbamazepine-responsive paroxysmal nausea and vomiting in a patient with meningeal carcinomatosis.
In neurology, paroxysmal syndromes are well-known, eg, as manifestations of multiple sclerosis. We report a patient with meningeal carcinomatosis, who presented with therapy-refractory nausea and vomiting. The clinical suspicion of a paroxysmal syndrome prompted a trial of carbamazepine, which resulted in complete cessation of the symptoms. In cancer patients with central nervous system (CNS) involvement and therapy-refractory symptoms with sudden onset, carbamazepine treatment should be considered.
Strohscheer
Imke
I
Section of Palliative Care, Medical University, Graz, Germany. imke.strohscheer@klinikum-graz.at
Borasio
Gian Domenico
GD
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use*; D001943:Breast Neoplasms; D002220:Carbamazepine / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy / Q000556:secondary*; D004351:Drug Resistance; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D009325:Nausea / Q000188:drug therapy* / Q000209:etiology; D013577:Syndrome; D014839:Vomiting / Q000188:drug therapy* / Q000209:etiology
D000927:Anticonvulsants; D000932:Antiemetics; D002220:Carbamazepine