Nasal polyp diseases in allergic and nonallergic patients and steroid therapy.
OBJECTIVE
To investigate widespread disease causes, cellular-structural differences, and steroid response of nasal polyps (NPs).


METHODS
Study group consisted of NPs, allergic-NPs, NPs with steroid therapy (ST), antrochoanal polyp (ACP), and controls. We investigated stromal eosinophil, mast cell, CD4+ and CD8+ cell counts and presence of squamous metaplasia, Ki-67 expression, intraepithelial eosinophils-mast cells, epithelial damage, edema, fibrosis, hyalinization, polymorphonuclear leukocyte, and glandular hyperplasia.


RESULTS
In allergic-NPs, intraepithelial eosinophils and epithelial damage CD4+ were significantly higher than NPs and also, eosinophils, mast cells, intraepithelial eosinophils, and epithelial damage were significantly higher than ACP. Only stromal eosinophilic infiltration was significantly higher in NPs than ACP. There was significant increased glandular hyperplasia and decreased intraepithelial eosinophils, mast cells, CD4+ cells, squamous metaplasia, and epithelial damage with ST in allergic-NPs. There were no significant differences with ST in NPs.


CONCLUSIONS
NPs in allergic and nonallergic patients may differ in their histology and in their histologic responses to ST.


METHODS
B-3b.
Alatas
Necat
N
Department of Otorhinolaryngology-Head and Neck Surgery, Harran University Medical Faculty, Sanliurfa, Turkey. necat66@yahoo.com
Baba
Fusun
F
San
Imran
I
Kurcer
Zehra
Z
D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D002648:Child; D015897:Comorbidity; D004804:Eosinophils; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D007150:Immunohistochemistry; D018655:Lymphocyte Count; D008297:Male; D008407:Mast Cells; D008875:Middle Aged; D009298:Nasal Polyps / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology