Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.
A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC(50)<100nM) and selectivity (SI>1000) against the pestivirus BVDV (bovine viral diarrhea virus).
Puerstinger
Gerhard
G
Institut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria. Gerhard.Puerstinger@uibk.ac.at
Paeshuyse
Jan
J
Herdewijn
Piet
P
Rozenski
Jef
J
De Clercq
Erik
E
Neyts
Johan
J
D000998:Antiviral Agents / Q000737:chemistry / Q000145:classification* / Q000494:pharmacology*; D002460:Cell Line; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects*; D007093:Imidazoles / Q000737:chemistry / Q000145:classification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000145:classification* / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D007093:Imidazoles; D011725:Pyridines