title: Subacute combined degeneration of the spinal cord concomitant with gastric cancer.
abstract: We report a rare case of subacute combined degeneration of the spinal cord concomitant with gastric cancer. A 67-year-old man was admitted because of posterior column symptoms, pyramidal tract sign and peripheral neuropathy with severe hyperchromic anemia. He was treated with mecobalamin 1 mg IM, after which his anemia and neurological signs recovered. He was diagnosed as having subacute combined degeneration with pernicious anemia. Subsequent stomach biopsy revealed gastric cancer, and the patient underwent gastrectomy. It is a well known association that chronic atrophic gastritis is associated with gastric cancer or subacute combined degeneration. Our findings suggest that in this case subacute combined degeneration and gastric cancer are independent of each other; rather, both resulted from chronic atrophic gastritis.
authors.affiliation: Department of Neurology, Toho University School of Medicine, Oohashi Hospital, Tokyo.
authors.forename: Ayako
authors.initials: A
authors.lastname: Hirata
authors.forename: Nobuatsu
authors.initials: N
authors.lastname: Nomoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Konno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakazora
authors.forename: Hideki
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nemoto
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Kurihara
authors.forename: Nobuo
authors.initials: N
authors.lastname: Wakata
mesh_terms: D000368:Aged; D000747:Anemia, Hypochromic / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D009410:Nerve Degeneration / Q000209:etiology* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: C019476:mecobalamin; D014805:Vitamin B 12