title: Hemorheological disorders in the microcirculation during septic shock in rats.
abstract: OBJECTIVE
  The aim of the present study was the experimental analysis of blood rheological disorders in the microcirculation during endotoxic shock.
  
  
  METHODS
  Experiments were carried out on 30 white laboratory rats of both sexes weighing about 200 g. The experimental animals were divided in two groups: the control group and the group undergoing experimental endotoxic shock. The following specific hemorheological properties were investigated in all animals during the experiments: red blood cells (RBC) aggregability, their deformability and the systemic hematocrit.
  
  
  RESULTS
  We found that all the investigated hemorheological parameters appreciably changed underconditions of endotoxic shock. The RBC aggregability index was increased by a mean of 136%. As to the RBC deformability index was found to be decreased by 71%, and the systemic hematocrit lowered by 31%, as compared to the same parameters in the control group.
  
  
  CONCLUSIONS
  The data obtained provide us with evidence that the hemorheological derangements associated with the development of the heavy microcirculatory disorders during endotoxic shock, are most significant factors.
authors.affiliation: Microcirculation Research Center, I. Beritashvili Institute of Physiology, 14 Gotua St., 0160, Tbilisi 0160, Georgia. tiko_sordi@yahoo.com
authors.forename: Tea
authors.initials: T
authors.lastname: Sordia
authors.forename: Jemal
authors.initials: J
authors.lastname: Tatarishvili
authors.forename: George
authors.initials: G
authors.lastname: Mchedlishvili
mesh_terms: D000818:Animals; D004903:Erythrocyte Aggregation / Q000187:drug effects* / Q000502:physiology; D004907:Erythrocyte Deformability / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006400:Hematocrit; D018056:Hemorheology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D051381:Rats; D012772:Shock, Septic / Q000097:blood* / Q000503:physiopathology
chemical_list: D008070:Lipopolysaccharides