title: [Effects of acupoint thread implantation and Chinese herb on PTH and TGF-beta1 in the rate of chronic renal failure].
abstract: OBJECTIVE
  To probe into the mechanisms of thread implantation at Zusanli(ST 36) and Chinese herbs in treatment of chronic renal failure(CRF).
  
  
  METHODS
  CRF rat model was made by Platt subtotal nephrectomy. They were divided into 5 groups, sham operation group, model group, Chinese herbs group, thread implantation group and thread implantation plus Chinese herbs group. After treatment of 8 weeks, serum parathyroid hormone (PHT), transforming growth factor beta1 (TGF-beta1) expression in residual renal cells, malondialdehyde(MDA) content in the residual renal tissue, serum urea nitrogen(BUN) and creatinine(Scr), protein in urine and pathological changes were investigated.
  
  
  RESULTS
  The above indexes after treatment by thread implantation at acupoint, Chinese herbs, and acupoint thread implantation plus Chinese herbs showed begin reversion, especially, the most obviously improvement in the acupoint thread implantation plus Chinese herbs treatment group.
  
  
  CONCLUSIONS
  The mechanism of acupoint thread implantation and Chinese herbs in improvement of CRF is related with decrease of PTH, inhibition of TGF-beta1 expression, decrease of MDA content and resisting lesion of renal fibrosis.
authors.affiliation: Guiyang City Maternity and Infant Health Institute, Guizhou 550003, China. ckz025@163.com
authors.forename: Kun-zhi
authors.initials: KZ
authors.lastname: Chen
authors.forename: Jing-li
authors.initials: JL
authors.lastname: Shi
authors.forename: Ming-zhuang
authors.initials: MZ
authors.lastname: Lü
authors.forename: Zhi-guang
authors.initials: ZG
authors.lastname: He
authors.forename: Ren-an
authors.initials: RA
authors.lastname: Qin
mesh_terms: D015669:Acupuncture Points; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000097:blood*; D053773:Transforming Growth Factor beta1
chemical_list: D004365:Drugs, Chinese Herbal; D010281:Parathyroid Hormone; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1