MicroRNAs: expression, avoidance and subversion by vertebrate viruses.
MicroRNAs (miRNAs), which can be expressed in a cell-type and tissue-specific manner, can influence the activities of genes that control cell growth and differentiation. Viruses often have clear tissue tropisms, raising the possibility that cellular miRNAs might modulate their pathogenesis. In this Review, we discuss recent findings that some vertebrate viruses either encode miRNAs or subvert cellular miRNAs, and that these miRNAs participate in both the infectious and the latent phase of the viral life cycle.
Sarnow
Peter
P
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94301, USA. psarnow@stanford.edu
Jopling
Catherine L
CL
Norman
Kara L
KL
Schütz
Sylvia
S
Wehner
Karen A
KA
D000818:Animals; D004267:DNA Viruses / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D015536:Down-Regulation; D016679:Genome, Viral; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D015854:Up-Regulation; D014714:Vertebrates / Q000821:virology
D035683:MicroRNAs