title: [Chronic renal disease in boys with posterior urethral valve].
abstract: Posterior urethral valve (PUV) is the most common anatomical cause of bladder outlet obstruction with an incidence ranging from 1/3000 to 1/8000 births. In spite of early valve ablation deterioration of renal function is frequently reported during childhood and adolescence.
  
  
  OBJECTIVE
  To evaluate the frequency and progression of chronic renal disease in boys born with PUV.
  
  
  METHODS
  The presence of chronic renal disease (CRD) in 58 boys with posterior urethral valve (PUV) was assessed by renal ultrasound and estimation of glomerular filtration rate (GFR). GFR was estimated by the method of Schwartz. Chronic renal disease was defined according to NFK K/DOQI Guidelines and classified into 5 stages.
  
  
  RESULTS
  48 (82%) patients with PUV had CRD. Among the patients observed from birth 89% already demonstrated CRD in the first year of life.
  
  
  CONCLUSIONS
  1. The vast majority of boys with PUV (83%) demonstrate symptoms of chronic renal disease. 2. CRD in boys with PUV is frequently evident from the first year of life. 3. PUV patients require regular nephrologic assessment from birth.
authors.affiliation: Klinika Nefrologii Dzieciecej, Akademii Medycznej w Gdańsku. mmaternik@amg.gda.pl
authors.forename: Michał
authors.initials: M
authors.lastname: Maternik
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zurowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Czarniak
authors.forename: Magdalena
authors.initials: M
authors.lastname: Drozyńska-Duklas
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kosiak
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gołebiewski
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D002908:Chronic Disease; D015897:Comorbidity; D018450:Disease Progression; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D014463:Ultrasonography; D014521:Urethra / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D001748:Urinary Bladder Neck Obstruction / Q000453:epidemiology