title: Whole genome RNAi screens for increased longevity: important new insights but not the whole story.
abstract: This article discusses the pros and cons of using RNAi screening to identify longevity genes in Caenorhabditis elegans. The discussion will focus on the results of two large-scale longevity RNAi screens that were recently published. The two screens revealed largely non-overlapping sets of candidate longevity genes. The possible reasons for such differences and their implications will be discussed.
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA. SSL29@cornell.edu
authors.forename: Siu Sylvia
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics; D015723:Gene Library; D049751:Genome, Helminth / Q000235:genetics; D008136:Longevity / Q000235:genetics; D023421:Models, Animal; D034622:RNA Interference; D018510:RNA, Helminth / Q000235:genetics*; D034741:RNA, Small Interfering / Q000235:genetics*
chemical_list: D029742:Caenorhabditis elegans Proteins; D018510:RNA, Helminth; D034741:RNA, Small Interfering