Possibility of spontaneous seeding of transitional cell carcinoma of the ureter in renal tubules: another mechanism of transitional cell carcinoma dissemination.
Cancer cell seeding inside the urinary tract always has been considered one possible mechanism of the multicentric origin of transitional cell carcinoma (TCC). However, there is still no direct clinical evidence to prove that the natural seeding of TCC is a real event. To our knowledge, we report the first case of spontaneous seeding of TCC of the ureter in the renal tubules of a hydronephrotic kidney. The TCC nature of the intratubular tumor cells has been confirmed by the morphological appearance of them after hematoxylin and eosin staining and positive p53 immunohistochemical staining.
Fong
Chau-Jye
CJ
Department of Surgery, Division of Urology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. fong410418@yahoo.com.tw
Chen
Toan
T
Hsieh
Dar-Shih
DS
Yen
Chung-Yang
CY
Chen
Hong-I
HI
D000368:Aged; D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D007684:Kidney Tubules / Q000473:pathology*; D009366:Neoplasm Seeding; D009392:Nephrectomy / Q000379:methods; D014516:Ureteral Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018666:Ureteroscopy; D014567:Urography