title: Histopathologic findings in primary erythromelalgia are nonspecific: special studies show a decrease in small nerve fiber density.
abstract: The histopathology of primary erythromelalgia has been poorly characterized. A total of 33 skin biopsy specimens from 29 patients with a diagnosis of primary erythromelalgia were re-examined. Histopathologic findings were nonspecific. Vascular thrombi were not identified. A relative decrease in small nerve fiber density was noted in specimens from 13 of 16 patients.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Mark D P
authors.initials: MD
authors.lastname: Davis
authors.forename: Roger H
authors.initials: RH
authors.lastname: Weenig
authors.forename: Joseph
authors.initials: J
authors.lastname: Genebriera
authors.forename: Gwen
authors.initials: G
authors.lastname: Wendelschafer-Crabb
authors.forename: William R
authors.initials: WR
authors.lastname: Kennedy
authors.forename: Paola
authors.initials: P
authors.lastname: Sandroni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004916:Erythromelalgia / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012867:Skin / Q000294:innervation* / Q000473:pathology*