title: Pediatric Epstein-Barr virus-associated encephalitis: 10-year review.
abstract: Many neurologic manifestations of Epstein-Barr virus (EBV) infection have been documented, including encephalitis, aseptic meningitis, transverse myelitis, and Guillain-Barré syndrome. These manifestations can occur alone or coincidentally with the clinical picture of infectious mononucleosis. Since 1994, The Hospital for Sick Children has maintained a prospective registry of all children admitted with acute encephalitis. This report summarizes all cases of Epstein-Barr virus-associated encephalitis compiled from 1994 to 2003. Twenty-one (6%) of 216 children, median age 13 years (range 3-17 years), in the Encephalitis Registry were identified as having evidence of Epstein-Barr virus infection. This evidence consisted of convincing Epstein-Barr virus serology and/or positive cerebrospinal fluid polymerase chain reaction (PCR). One patient had symptoms of classic infectious mononucleosis; all others had a nonspecific prodrome, including fever (n = 17; 81%) and headache (n = 14; 66%). Slightly less than half (n = 10; 48%) had seizures and often had electroencephalograms showing a slow background (n = 12; 57%). Many demonstrated cerebrospinal fluid pleocytosis (n = 17; 81%), and 71% (n = 15) had abnormal magnetic resonance imaging findings. Two patients died, 2 suffered mild deficits, and 16 were neurologically normal at follow-up. Most patients with Epstein-Barr virus encephalitis do not show typical symptoms of infectious mononucleosis. Establishing a diagnosis of Epstein-Barr virus encephalitis can be difficult, and, consequently, a combination of serologic and molecular techniques should be used when investigating a child with acute encephalitis. Most children make full recoveries, but residual neurologic sequelae and even death can and do occur.
authors.affiliation: Division of Neurology, Department of Pediatrics, The Hospital for Sick Children and the University of Toronto, ON, Canada.
authors.forename: Asif
authors.initials: A
authors.lastname: Doja
authors.forename: Ari
authors.initials: A
authors.lastname: Bitnun
authors.forename: Elizabeth Lee
authors.initials: EL
authors.lastname: Ford Jones
authors.forename: Susan
authors.initials: S
authors.lastname: Richardson
authors.forename: Raymond
authors.initials: R
authors.lastname: Tellier
authors.forename: Martin
authors.initials: M
authors.lastname: Petric
authors.forename: Helen
authors.initials: H
authors.lastname: Heurter
authors.forename: Daune
authors.initials: D
authors.lastname: MacGregor
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D018792:Encephalitis, Viral / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000097:blood; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D017063:Outcome Assessment, Health Care; D012042:Registries; D012189:Retrospective Studies; D012698:Serologic Tests
chemical_list: D019309:Epstein-Barr Virus Nuclear Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M