[Features of a cytokine profile in patients with chronic glomerulonephritis with progressive chronic renal failure].
OBJECTIVE
To specify the cytokine profile in chronic glomerulonephritis (CGN) with aggravating renal function, to assess prognostic value of some cytokines in development of CGN in these patients.


METHODS
Indices of the cytokine profile were followed up in 56 CGN patients with nephrotic syndrome and arterial hypertension and compared in those patients who developed CGN for 2 years (group 2) versus patients with intact renal function (group 1).


RESULTS
Serum levels of IL-1beta and TNF-alpha were maximal in CGN patients with aggravating renal function. Such patients had a low concentration of serum IL-1beta receptors antagonists. Severity of proteinurea correlated with serum level of TNF-alpha. If the latter was higher than 120 pg/ml, there was a high probability of CRF development within 2 years.


CONCLUSIONS
Pathogenesis of CRF in CGN is associated with proinflammatory cytokines, especially TNF-alpha. Its serum concentration can be used for evaluating risk of renal function deterioration.
Koriakova
N N
NN
Rozhdestvenskaia
E D
ED
Kazantseva
S V
SV
Bushueva
T V
TV
Valamina
I E
IE
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology*; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications; D007375:Interleukin-1 / Q000097:blood* / Q000276:immunology*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology / Q000652:urine; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000378:metabolism*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha