Microalbuminuria: a marker of endothelial dysfunction in thermal injury.
BACKGROUND
Systemic endothelial dysfunction (SED) and capillary leak occur following severe burn. SED can be assessed as low-level albuminuria (microalbuminuria) detectable only by sensitive immunoassay. This study compared the magnitude and duration of microalbuminuria with burn surface area and associated aggravating factors.


METHODS
Serial urine specimens were collected from 2 to 36 h after injury from 43 adult burn patients with a mean total body surface area (TBSA) of 32% (range 15-68%) and during 44 episodes of wound manipulation within the same period. Urinary albumin was expressed as the albumin/creatinine ratio (ACR, normal <2.3 mg/mmol).


RESULTS
Median ACR was highest 2h after injury (12.3 range 1.8-118 mg/mmol) returning to normal within 6 h. Full thickness burns (mean 17%) showed a significant association with ACR between 3 and 7h after burn. ACR was higher for up to 8 h in the presence of inhalation injury, alcohol intoxication or accelerant (p<0.05). ACR rose within 30 min of escharotomy or wound scrubbing (p<0.01).


CONCLUSIONS
Severe burn produces variable SED which recurs with wound manipulation. Inhalation injury, alcohol intoxication and accelerant all showed a stronger association with SED than TBSA. Microalbuminuria provides a means of monitoring microvascular integrity during the early after injury period.
Vlachou
E
E
University Hospital Birmingham, UK. lilly@doctors.org.uk
Gosling
P
P
Moiemen
N S
NS
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000175:diagnosis*; D000435:Alcoholic Intoxication / Q000150:complications; D015415:Biomarkers / Q000652:urine; D001830:Body Surface Area; D002056:Burns / Q000473:pathology / Q000652:urine*; D002196:Capillaries; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014652:Vascular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology
D015415:Biomarkers