[The role of some selected risk factors in the development of the nephrotoxicity of immunosuppressive medications used after the heart transplantation in children and young adults].
The goal of this research was the assessment of non-genetic and genetic risk factors of renal lesions in children after heart transplants. The research was carried out in 22 pediatric heart transplant recipients who have had a long-term treatment with calcineurin inhibitors. Renal function was assessed directly after the transplantation and then in 3 months intervals with the monitoring of calcineurin inhibitors concentration in the plasma. A significant renal lesion has been confirmed, which was a time-function in all examined patients, although its severity varied. Acute renal insufficiency, transplant rejection and ATG usage in the peri-transplant and the post-transplant periods have not proven to influence the complications mentioned above. The relationship between "high TGFbeta production genotype" and the intensity of nephrotoxicity of calcineurin inhibitors has been confirmed.
Hyla-Klekot
Lidia
L
Chorzowskie Centrum Pediatrii i Onkologii.
Kucharska
Grazyna
G
D000293:Adolescent; D000328:Adult; D065095:Calcineurin Inhibitors; D002648:Child; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects*; D051437:Renal Insufficiency / Q000139:chemically induced*; D012307:Risk Factors; D016896:Treatment Outcome
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016572:Cyclosporine