title: Effect of isoflurane on echocardiographic left-ventricular relaxation indices in patients with diastolic dysfunction due to concentric hypertrophy and ischemic heart disease.
abstract: OBJECTIVE
  The purpose of this study was to investigate whether isoflurane, a known negative lusitropic agent, exacerbates diastolic dysfunction in patients with preexisting impaired relaxation.
  
  
  METHODS
  Prospective, experimental study.
  
  
  METHODS
  Single-institution, university hospital.
  
  
  METHODS
  Twenty-five patients with diastolic dysfunction due to concentric hypertrophy and ischemic heart disease undergoing elective coronary artery bypass graft surgery.
  
  
  METHODS
  After approval of the local ethics committee and informed consent, patients randomly received sufentanil/midazolam anesthesia plus either 0.5 to 1.0 minimum alveolar concentration of isoflurane (n = 15) or weight-adjusted boli of urapidil (n = 10) during preparation of the internal mammary artery. Changes in hemodynamic parameters and echocardiographic diastolic indices before and after drug administration were compared. Filling pressures during the study were kept constant within normal range.
  
  
  RESULTS
  Hemodynamic changes measured by invasive arterial and pulmonary arterial pressures were comparable between isoflurane and urapidil. Both interventions led to a marked reduction in afterload that was accompanied by a significant increase in thermodilution cardiac output and stroke volume. Transesophageal echocardiographic relaxation indices were also comparable between groups. Transmitral and tissue Doppler E waves increased significantly, leading to larger E/A and Em/Am ratios; whereas the deceleration time and the isovolumetric relaxation time decreased significantly.
  
  
  CONCLUSIONS
  Isoflurane did not exacerbate diastolic dysfunction in patients with concentric hypertrophy and ischemic heart disease. In contrast, isoflurane led to a "normalization" of the relaxation pattern that was attributed to a reduction in left-ventricular loading conditions.
authors.affiliation: Department of Anaesthesiology, Intensive Care Medicine, Pain Treatment, University Hospital Giessen, Giessen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Neuhäuser
authors.forename: Matthias
authors.initials: M
authors.lastname: Müller
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Welters
authors.forename: Stefan
authors.initials: S
authors.lastname: Scholz
authors.forename: Myron M
authors.initials: MM
authors.lastname: Kwapisz
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous; D000959:Antihypertensive Agents / Q000494:pharmacology; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D001026:Coronary Artery Bypass; D003971:Diastole / Q000187:drug effects*; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications*; D006993:Hypnotics and Sedatives; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000601:surgery; D010879:Piperazines / Q000494:pharmacology; D017409:Sufentanil; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000959:Antihypertensive Agents; D006993:Hypnotics and Sedatives; D010879:Piperazines; C015568:urapidil; D017409:Sufentanil; D007530:Isoflurane; D008874:Midazolam