title: In vitro susceptibilities of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region: 2004 results from SMART (Study for Monitoring Antimicrobial Resistance Trends).
abstract: In the 2004 Study for Monitoring Antimicrobial Resistance Trends (SMART), 14 centres from six countries in Asia-Pacific collected 1198 unique aerobic and facultative Gram-negative bacilli from intra-abdominal infections for susceptibility testing to 12 antimicrobial agents. Enterobacteriaceae comprised 82% of the total isolates. Escherichia coli was the most commonly isolated species (43%). Resistance rates were generally higher in Enterobacteriaceae isolated from Asian centres than those isolated from Oceania centres. There was little difference in susceptibility rates between community- and hospital-acquired Enterobacteriaceae for carbapenems. Extended-spectrum beta-lactamase (ESBL)-producers typically had a more resistant profile than non-ESBL-producers, but were usually susceptible to carbapenems. Of the antimicrobial agents tested, carbapenems were the most reliably active in vitro against Enterobacteriaceae recovered from patients in Asia-Pacific with intra-abdominal infections.
authors.affiliation: Department of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Po-Ren
authors.initials: PR
authors.lastname: Hsueh
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Snyder
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Dinubile
authors.forename: Vilas
authors.initials: V
authors.lastname: Satischandran
authors.forename: Kathleen
authors.initials: K
authors.lastname: McCarroll
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Chow
mesh_terms: D000005:Abdomen; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia; D017714:Community-Acquired Infections / Q000382:microbiology; D003428:Cross Infection / Q000382:microbiology; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D044349:Oceania
chemical_list: D000900:Anti-Bacterial Agents