Catheter-related fungemia due to Candida thermophila.
We report a case of bloodstream infection caused by Candida thermophila, a yeast not previously associated with human disease. The infection occurred in a 13-year-old boy with medulloblastoma who presented with 1 day of fever. Multiple blood cultures were positive for yeast. Removal of the catheter resulted in prompt resolution of the fever and sterilization of the blood cultures. The species was identified by sequencing domains 1 and 2 of the large subunit rRNA gene. Antifungal susceptibility testing was also performed.
Bar-Meir
Maskit
M
Children's Memorial Hospital, Northwestern University Feinberg School of Medicine, 2300 Children's Plaza, Box 53, Chicago, IL 60614, USA.
Sutton
Deanna A
DA
Wickes
Brian
B
Kurtzman
Cletus P
CP
Goldman
Stewart
S
Zheng
Xiaotian
X
D000293:Adolescent; D000935:Antifungal Agents / Q000494:pharmacology; D001769:Blood / Q000382:microbiology; D002175:Candida / Q000145:classification* / Q000302:isolation & purification*; D002177:Candidiasis / Q000209:etiology* / Q000382:microbiology; D002408:Catheters, Indwelling / Q000009:adverse effects*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D005334:Fever; D016469:Fungemia / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000150:complications* / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010802:Phylogeny; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D012337:RNA, Ribosomal, 18S