Seven-transmembrane receptor signalling and ERK compartmentalization.
Vast numbers of extracellular signalling molecules exert effects on their target cells by activation of a relatively limited number of mitogen-activated protein kinase (MAPK) cascades, raising the question of how specificity is achieved. To a large extent, this appears to be attributable to differences in kinetics and compartmentalization of MAPK protein activation that are dictated by MAPK-associated proteins serving as scaffolds, anchors, activators or effectors. Here, we review spatiotemporal aspects of signalling via the Ras-Raf-extracellular signal-regulated kinase pathway, emphasizing recent work on roles of arrestins as scaffolds and transducers for seven transmembrane receptor signalling.
Caunt
Christopher J
CJ
University of Bristol, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Whitson Street, Bristol, BS1 3NY, UK.
Finch
Ann R
AR
Sedgley
Kathleen R
KR
McArdle
Craig A
CA
D000818:Animals; D019390:Arrestins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D019390:Arrestins; D011956:Receptors, Cell Surface; D048049:Extracellular Signal-Regulated MAP Kinases