Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis.
Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10-year-old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associated with mild pancreatitis. Hypertriglyceridemia was successfully managed with plasmapheresis with a decrease in triglyceride levels to 590 mg/dl. Apheresis appears to be safe and effective in reducing hypertriglyceridemia and preventing related complications.
Ridola
Vita
V
Department of Pediatric Oncology, Catholic University of Rome, Rome, Italy. vita.ridola@rm.unicatt.it
Buonuomo
Paola Sabrina
PS
Maurizi
Palma
P
Putzulu
Rossana
R
Annunziata
Maria Laura
ML
Pietrini
Domenico
D
Riccardi
Riccardo
R
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000209:etiology / Q000628:therapy*; D007937:Leukapheresis; D008297:Male; D010956:Plasmapheresis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy / Q000628:therapy; D012074:Remission Induction; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D001215:Asparaginase