Effect of a high-fat meal on the growth hormone response to exercise in children.
Exercise-induced growth hormone (GH) secretion may significantly modulate growth and development in children. Altered physiological GH responses, therefore, may reduce the beneficial effects of exercise. High-fat food ingestion before exercise blunts the GH response in adults, but it is unknown whether this occurs in children. We therefore performed standard exercise tests, following a high-fat meal or placebo, in 12 children, age 11-15 (6 M, 6 F). GH, insulin-like growth factor-I, glucose, insulin, glucagon, cortisol, epinephrine and interleukin-6 samples were drawn at baseline, end-exercise, and 30 and 60 min post-exercise. While GH was similar at baseline in all experiments, the exercise-induced GH peak was lower after the high-fat meal (6.7 +/- 1.6 ng/l vs 11.8 +/- 2.4 ng/l, p <0.02). Other exercise responses were not affected by prior fat ingestion. A high-fat meal before exercise, therefore (a common event in Western societies), may reduce the growth factor response to exercise in children, with potential implications for growth and development.
Galassetti
Pietro
P
General Clinical Research Center and Department of Pediatrics, University of California Irvine School of Medicine, USA. pgalasse@uci.edu
Larson
Jennifer
J
Iwanaga
Kensho
K
Salsberg
Sandra L
SL
Eliakim
Alon
A
Pontello
Andria
A
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D005080:Exercise Test; D005260:Female; D005934:Glucagon / Q000097:blood; D013006:Growth Hormone / Q000097:blood*; D006133:Growth Substances / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010919:Placebos; D013997:Time Factors
D001786:Blood Glucose; D004041:Dietary Fats; D006133:Growth Substances; D007328:Insulin; D015850:Interleukin-6; D010919:Placebos; D013006:Growth Hormone; D005934:Glucagon; D006854:Hydrocortisone; D004837:Epinephrine