title: Preparation of PVA/PEI ultra-fine fibers and their composite membrane with PLA by electrospinning.
abstract: Ultra-fine fibers of poly(vinyl alcohol)/polyethylenimine (PVA/PEI) were prepared by electrospinning of their blend solutions in water. Effects of PVA/PEI mass ratio and the polymer concentration on the fiber morphology were discussed by analysis of scanning electron micrographs. Results showed that uniform ultra-fine fibers could be obtained from an 8% PVA/PEI solution with 75:25 mass ratio. It was supposed that the introduction of PVA could promote electrospinning of PEI by weakening the intermolecular interaction and increasing solution viscosity. A composite membrane of PVA/PEI with poly(D,L-lactide) (PLA) was produced by co-electrospinning simultaneously from the aqueous 8% PVA/PEI (75:25) solution and a 20% PLA solution in N,N-dimethylformamide in two separated syringes. Fourier transform infrared spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy verified the existence of PVA/PEI and PLA in the fibrous membrane. We attempted to incorporate PEI with PLA as ultra-fine fibers to diminish the acidic inflammation caused by biodegradation of PLA. The fibrous composite membrane of PVA/PEI-PLA could provide better biocompatibility and would be used as drug-delivery carriers or tissue-engineering scaffolds.
authors.affiliation: School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Cunhai
authors.initials: C
authors.lastname: Dong
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Yuan
authors.forename: Mingyu
authors.initials: M
authors.lastname: He
authors.forename: Kangde
authors.initials: K
authors.lastname: Yao
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000302:isolation & purification*; D004563:Electrochemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry / Q000302:isolation & purification*; D011094:Polyethyleneimine / Q000737:chemistry / Q000302:isolation & purification*; D011142:Polyvinyl Alcohol / Q000737:chemistry / Q000302:isolation & purification*; D017550:Spectroscopy, Fourier Transform Infrared; D013057:Spectrum Analysis; D013499:Surface Properties; D014961:X-Ray Diffraction; D014965:X-Rays
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide); D011142:Polyvinyl Alcohol; D011094:Polyethyleneimine