title: [Effect of sodium fluoride on the activity of sorbitol dehydrogenase in plasma and liver of rabbits with experimental atherosclerosis].
abstract: This study was done in rabbits placed on a low-cholesterol (0.5 g%) and high-cholesterol (2.0 g%) diet to induce experimental atherosclerosis. The intake of fluorine in the form of NaF in water was 3 mg F(-)/kg b.w./24 h. The activity of sorbitol dehydrogenase (SDH) was increased in plasma and decreased in the liver of rabbits on the high-cholesterol diet and in animals simultaneously exposed to NaF in water. Two months of the low-cholesterol diet produced an increase in SDH activity in plasma as a direct consequence of exposure to fluoride in the diet and presumably caused by accumulation of fluoride in the liver.
authors.affiliation: Zakład Biochemii Ogólnej Katedry Biochemii w Zabrzu Slaskiej Akademii Medycznej w Katowicach ul. Jordana 19, 41-808 Zabrze.
authors.forename: Ewa
authors.initials: E
authors.lastname: Birkner
authors.forename: Ewa
authors.initials: E
authors.lastname: Grucka-Mamczar
authors.forename: Sławomir
authors.initials: S
authors.lastname: Kasperczyk
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kasperczyk
authors.forename: Jolanta
authors.initials: J
authors.lastname: Zalejska-Fiolka
authors.forename: Beata
authors.initials: B
authors.lastname: Birkner
authors.forename: Beata
authors.initials: B
authors.lastname: Pieczyrak
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000139:chemically induced / Q000201:enzymology*; D002791:Cholesterol, Dietary; D007064:L-Iditol 2-Dehydrogenase / Q000187:drug effects*; D008099:Liver / Q000201:enzymology*; D011817:Rabbits; D012969:Sodium Fluoride / Q000494:pharmacology*
chemical_list: D002791:Cholesterol, Dietary; D012969:Sodium Fluoride; D007064:L-Iditol 2-Dehydrogenase