[Clinical value of changes in red blood cell ultrastructure and energy metabolism in children with cystic fibrosis of the pancreas].
In 42 patients of various age (from 1 month to 14 years) with cystic fibrosis were analyzed ultra structure, level of adenylnukleotides and activity of ATP-ase of erythrocytes, in order to characterize their membrane and energy metabolism . Our recent studies revealed increase of ATP-ase and decrease of ATP of erythrocytes, in children both with bronchopulmonary and mixed form of cystic fibrosis. In patients with lethal outcome were detected more significant decrease of the ATP combined with increase of ATP-ase in erythrocytes then in other cases, which is resulted not only by suppressed glycolic processes but also by exhausted compensative-adaptive abilities of the human organism in whole. In patients with cystic fibrosis were detected changes both in quantity and quality of erythrocytes' stereoultrastructure: the level of the discocytes was significantly decreased, while the level of all other 12 types of erythrocytes were increased, also there were detected appearance of erythrocytes with pathogenic forms. The changes mentioned above were more apparent in patients with mixed form of cystic fibrosis and lethal outcome. The results of our study have a great value for medical practice providing more precise diagnosis, in time correction of disorders and a comprehensive assessment of multiple-modality treatment of cystic fibrosis.
Badriashvili
N R
NR
Topuridze
N L
NL
Chakhunashvili
G S
GS
Tabutsadze
D O
DO
Khvitisiashvili
N O
NO
D000251:Adenosine Triphosphatases / Q000032:analysis; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000473:pathology*; D004734:Energy Metabolism; D004910:Erythrocyte Membrane / Q000648:ultrastructure; D004912:Erythrocytes / Q000201:enzymology / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008855:Microscopy, Electron, Scanning; D010182:Pancreatic Diseases / Q000473:pathology*
D000251:Adenosine Triphosphatases