title: A case of systemic lupus erythematosus expressing intractable thrombocytopenia remedied effectively by intermittent and continuous administrations of a small amount of immune globulin.
abstract: We describe a case where intermittent and continuous administrations of a small amount of immune globulin were effective in the treatment of refractory chronic immune thrombocytopenic purpura by systemic lupus erythematosus (SLE). Steroid pulse therapy and cyclophosphamide pulse therapy were considered for thrombopenia. However, the patient had compressed fracture of the lumbar vertebrae due to osteoporosis and right external malleolus ulcer with complications of infection. Therefore, high-dose intravenous immune globulin (IVIG) therapy (400 mg/kg daily for 5 consecutive days) was administered. Then, as a maintenance therapy, a small amount of 400 mg/kg for 1 day (400 mg/kg monthly) was given in an intermittent and continuous manner, which resulted in improvement of thrombocytopenia and reduction of the amount of steroid administered.
authors.affiliation: Department of Health and Sport Management, Osaka University of Health and Sport Sciences, 1-1 Asashirodai, Kumatoricho, Sennan, Osaka, 590-0496, Japan. etsukom@ouhs.ac.jp
authors.forename: Etsuko
authors.initials: E
authors.lastname: Maeshima
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kida
authors.forename: Mikako
authors.initials: M
authors.lastname: Goda
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Minami
mesh_terms: D002908:Chronic Disease; D005260:Female; D050815:Fractures, Compression / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology* / Q000276:immunology / Q000628:therapy*; D012074:Remission Induction; D013256:Steroids / Q000008:administration & dosage
chemical_list: D016756:Immunoglobulins, Intravenous; D013256:Steroids