[Hypersensitivity reactions to multiple drugs during the course of hairy cell leukemia treated with 2-chlorodeoxyadenosine].
A 38-year-man developed diffuse erythema 3 days after the administration of 2-chlorodeoxyadenosine (cladribine or 2-CdA) and many other drugs for hairy cell leukemia (HCL). Patch-testing and scratch patch-testing showed positive reactions for clindamycin (10%, 30%) at 24 hours and 48 hours. Furthermore, provocation-testing showed positive reactions for sulfamethoxazole.trimethoprim, allopurinol, fluconazole, so our diagnosis was erythroderma-type drug eruption due to clindamycin, sulfamethoxazole-trimethoprim, allopurinol, fluconazole. Cutaneous side-effects associated with cladribine have seldom been described in cases of HCL. Our case suggests that there is a relationship between the drug hypersensitivity and the prolonged suppressed CD4 cell levels caused by cladribine.
Kokunai
Akiko
A
Department of Dermatology, Graduate School of Medicine, Osaka University. karakara@hbk.pref.osaka.jp
Azusawa
Hiroaki
H
Murota
Hiroyuki
H
Ohhata
Chika
C
Katayama
Ichiro
I
Murata
Shinsuke
S
Tadokoro
Seiji
S
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017338:Cladribine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy*; D008297:Male
D000970:Antineoplastic Agents; D017338:Cladribine