Rough sheets and smooth tubules.
The endoplasmic reticulum (ER) has distinct morphological domains composed of sheets and tubules, which differ in their characteristic membrane curvature. Key proteins may drive the formation of these structural morphologies, which in turn could generate the rough and smooth functional domains of the ER.
Shibata
Yoko
Y
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Voeltz
Gia K
GK
Rapoport
Tom A
TA
D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism / Q000648:ultrastructure; D018870:Endoplasmic Reticulum, Rough / Q000378:metabolism* / Q000648:ultrastructure*; D018871:Endoplasmic Reticulum, Smooth / Q000378:metabolism* / Q000648:ultrastructure*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism / Q000648:ultrastructure; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D014176:Protein Biosynthesis / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism; D013256:Steroids / Q000096:biosynthesis
D013256:Steroids