Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.
BACKGROUND
Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD).


OBJECTIVE
To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx).


METHODS
A retrospective review was performed in children with SBS-IFALD undergoing LTx and comparison made with weight, age-matched children undergoing iLTX (extra-hepatic biliary atresia (EHBA) and normal intestinal length and function).


RESULTS
Seven children with SBS-IFALD undergoing iLTx (median residual bowel length, 60 cm, range 40-80) were compared with 15 children undergoing LTx for EHBA. SBS-IFALD children had significantly lower trough tacrolimus levels at three months (5.8 vs. 7.9 ng/mL, p<0.05) and six months (5.0 vs. 8.0 ng/mL, p<0.05), but equivalent levels at 12 months after iLTx. The median calculated dose-normalized concentrations indicated that systemic availability of tacrolimus was comparable in two groups at 3, 6, 12 months (33.1 vs. 23.3; 42.4 vs. 36; 51 vs. 52.9) despite the differences in enteral function. The incidence of acute rejection was 1/7 (SBS-IFALD) and 10/15 (EHBA) group (p = 0.06).


CONCLUSIONS
Children with SBS-IFALD demonstrated adequate absorption of oral tacrolimus without significant acute rejection rate after iLTx suggesting that modification of immunosuppression is not necessary.
Olio
Dominic Dell
DD
The Liver Unit, Birmingham Children's Hospital (BCH), Birmingham, UK. Dominic.Dell-Olio@bch.nhs.uk
Gupte
Girish
G
Sharif
Khalid
K
Murphy
M S
MS
Lloyd
Carla
C
McKiernan
Patrick J
PJ
Kelly
Deirdre A
DA
Beath
Susan V
SV
D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D016031:Liver Transplantation; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies; D012778:Short Bowel Syndrome / Q000601:surgery*; D018709:Statistics, Nonparametric; D016559:Tacrolimus / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D011239:Prednisolone; D016559:Tacrolimus; D008775:Methylprednisolone