title: [Analysis of DC-SIGN and DC-SIGNR genetic polymorphism in Chinese Han population].
abstract: OBJECTIVE
  To understand the genetic polymorphism of DC-SIGN's and DC-SIGNR's neck regions in normal Chinese Han population, and to obtain the genetic data of the two loci in Chinese Han population.
  
  
  METHODS
  The genotypes and alleles of repeat sequences of DC-SIGN and DC-SIGNR neck region were typed by PCR, agarose gel electrophoresis and sequencing. Polymorphism information content (PIC) of DC-SIGNR was calculated.
  
  
  RESULTS
  DC-SIGN genetic polymorphism was rare. Allele 7 was most and its frequency was 0.9808. 4-, 5-, 6- and 8- alleles were also found, although their frequencies were very low. Caucasians had only 6- and 8- allele mutants; DC-SIGNR genetic polymorphism was high, its PIC was 0.5312, 4-,5-,6-,7-,8-,9- alleles and 16 genotypes were found in normal Chinese Han population. The differences of 6/5,7/4,7/5,7/6,7/7,9/5,9/7,9/9 genotypes distribution and 5-,6-,7-,9- alleles frequency between normal Chinese Han population and Caucasian population were all extremely distinct (P<0.01). The inserted mutation seemed more in Chinese Hans than Caucasian population.
  
  
  CONCLUSIONS
  DC-SIGN and DC-SIGNR genotypes and alleles distribution in Chinese Han population are significantly different from Caucasian population and with Chinese own population genetic characteristics, compared with Caucasians.
authors.affiliation: Department of AIDS Clinical Research, Shenzhen Donghu Hospital, Shenzhen, Guangdong 518020, P. R. China. huiwang98@yahoo.com
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Ya-dong
authors.initials: YD
authors.lastname: Hu
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Wang
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Dong
authors.forename: Li-xiong
authors.initials: LX
authors.lastname: Li
authors.forename: Fu-ping
authors.initials: FP
authors.lastname: Liu
authors.forename: Lu-biao
authors.initials: LB
authors.lastname: Yan
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Xing-deng
authors.initials: XD
authors.lastname: Tong
authors.forename: Ling-ling
authors.initials: LL
authors.lastname: Shi
authors.forename: Xin
authors.initials: X
authors.lastname: Xiao
authors.forename: Tuo-fu
authors.initials: TF
authors.lastname: Zhu
authors.forename: Bo-ping
authors.initials: BP
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*; D055815:Young Adult; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human