Azole resistance of Candida glabrata in a case of recurrent fungemia.
We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.
Posteraro
Brunella
B
Department of Microbiology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome 00168, Italy.
Tumbarello
Mario
M
La Sorda
Marilena
M
Spanu
Teresa
T
Trecarichi
Enrico Maria
EM
De Bernardis
Flavia
F
Scoppettuolo
Giancarlo
G
Sanguinetti
Maurizio
M
Fadda
Giovanni
G
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology; D001393:Azoles / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology; D041221:Candida glabrata / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005260:Female; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology*; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D006801:Humans; D012008:Recurrence; D014621:Vagina / Q000382:microbiology
D000935:Antifungal Agents; D001393:Azoles; D000666:Amphotericin B