title: Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 1: Fluorides.
abstract: Radiation-induced xerostomia results in significant changes in the oral cavity particularly oral microbial changes, which include a marked increase in the number of cariogenic organisms, notably Streptococcus mutans and lactobacillus species. This loss of the capacity to secrete saliva creates or promotes the rapid onset and progression of rampant dental caries. In this 2-part series, the benefit of fluoride in reducing caries activity is presented. Part 1 discusses the historical and currently available fluoride preparations and Part 2 presents data of a recently completed trial investigating the benefit of an intraoral sodium fluoride releasing system.
authors.affiliation: Department of Head and Neck Surgery, Department of Radiation Oncology, M.D. Anderson Cancer Center, Houston, TX 77030, USA. mchamber@mdanderson.org
authors.forename: Mark S
authors.initials: MS
authors.lastname: Chambers
authors.forename: James R
authors.initials: JR
authors.lastname: Mellberg
authors.forename: Harris J
authors.initials: HJ
authors.lastname: Keene
authors.forename: Otis J
authors.initials: OJ
authors.lastname: Bouwsma
authors.forename: Adam S
authors.initials: AS
authors.lastname: Garden
authors.forename: Tibor
authors.initials: T
authors.lastname: Sipos
authors.forename: Terence J
authors.initials: TJ
authors.lastname: Fleming
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D003731:Dental Caries / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D005457:Fluoridation; D006801:Humans; D009062:Mouth Neoplasms / Q000382:microbiology / Q000532:radiotherapy; D009067:Mouthwashes; D011878:Radiotherapy / Q000009:adverse effects; D012969:Sodium Fluoride / Q000627:therapeutic use*; D013290:Streptococcal Infections / Q000150:complications / Q000517:prevention & control; D013295:Streptococcus mutans; D013607:Tablets; D014100:Toothpastes; D014987:Xerostomia / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D009067:Mouthwashes; D013607:Tablets; D014100:Toothpastes; D012969:Sodium Fluoride