Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism.
The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated control subjects of Korean origin. Associations between genotype, allele, and haplotype frequencies of the polymorphisms and alcoholism were investigated. The genotype frequencies of rs1806201 and the haplotype analysis of SNPs in this study show significantly differences between the case and controls. These findings suggest new candidate SNPs in GRIN2B for studying the genetic susceptibility to alcoholism.
Kim
Jin Hee
JH
Department of Pharmacology, School of Medicine, Eulji University, 143-5 Yongdu Dong, Jung Gu, Daejeon 301-832, Republic of Korea.
Park
Mira
M
Yang
So Young
SY
Jeong
Bum Seok
BS
Yoo
Hee Jeong
HJ
Kim
Jong-Woo
JW
Chung
Joo-Ho
JH
Kim
Soon Ae
SA
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology / Q000235:genetics*; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate