[Clinical features and CD38 polymorphisms of latent autoimmune diabetes of adults (LADA) in Chengdu].
OBJECTIVE
To find out the clinical characteristic elements as parameters and detect the polymorphism at PvU II endonuclease site and Arg(140) Trp mutation of the CD38 gene of LADA patients in the Chengdu area.


METHODS
The clinical parameters, islet cell-specific autoantibodies, C-peptide levels, genetic and mutation frequency of the CD38 gene in 44 patients with LADA and 67 patients with T2DM were investigated and compared with those in 25 normal controls.


RESULTS
The patients of 30-50 years of age had higher prevalence of LADA. A number of LADA patients were obese or over-obese. The positivity of GAD-Ab, ICA and IAA declined with the increase of age. Both LADA and T2DM patients had the polymorphisms of B/B and A/B of the CD38 gene, but the healthy controls did not have such polymorphisms. Arg1140 Trp mutation was not found in both patients and healthy controls.


CONCLUSIONS
This research revealed no relationship between the on-set of LADA and the CD38 polymorphism and CD38 Arg(140) Trp mutation.
Liu
Li-mei
LM
Department of Endocrinology and Medabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
Xiu-jun
XJ
Chen
Zi-yang
ZY
D051997:ADP-ribosyl Cyclase 1 / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001323:Autoantibodies / Q000097:blood; D002681:China; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic
D001323:Autoantibodies; D004720:Endonucleases; D051997:ADP-ribosyl Cyclase 1