title: Isolation of Propionibacterium acnes from central nervous system infections.
abstract: Propionibacterium acnes is a common skin colonizer and its involvement in central nervous system (CNS) infections may be related with previous neurosurgical procedures. P. acnes was isolated in pure or mixed cultures from ten patients with CNS infections during a 5-year period. The clinical presentation, treatment and outcome were retrospectively reviewed. Nine out of 11 patients had CNS infections after a neurosurgical procedure. The clinical presentation was: brain abscess (five patients), subdural or epidural empyema (four patients) and shunt meningitis (one patient). Three patients had also secondary meningitis. All patients received antibiotic therapy and all abscesses and empyemas were drained. The patient with shunt meningitis cured without catheter removal. Only one patient with a brain abscess by P. acnes died, but several months thereafter and as a consequence of a Gram-negative superinfection. P. acnes is a pathogen for the CNS and infections must be surgically managed under adequate antibiotic treatment.
authors.affiliation: Department of Medical Microbiology, Fundacion Jimenez Diaz, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Ramos
authors.forename: J
authors.initials: J
authors.lastname: Esteban
authors.forename: F
authors.initials: F
authors.lastname: Soriano