[Production of interferon-gamma and interleukin-10 by splenic cells of mice infected with Toxoplasma gondii or immunized with antigens of killed parasites].
Splenic lymphocytes from T. gondii infected mice produced high levels of IFN-gamma in vitro. The production of IFN-gamma was increasing until 10-th day of infection, reaching a level 1600-fold higher to that found in control cultures, then it began to decrease. The level of IL-10 released by lymphocytes to the medium was also increasing up to the 10-th day of infection, afterwards its content dropped down to the level 18-fold higher than that at the beginning of experiments. There were no effects of immunization with antigens of killed parasites on the production of IFN-gamma by splenic cells in vitro.
Konopka
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Zakład Parazytologii Lekarskiej PZH, 00-791 Warszawa, ul. Chocimska 24.
Dzbeński
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D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology / Q000302:isolation & purification; D002478:Cells, Cultured; D007114:Immunization / Q000379:methods; D007371:Interferon-gamma / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014122:Toxoplasma / Q000276:immunology* / Q000302:isolation & purification; D014124:Toxoplasmosis, Animal / Q000276:immunology* / Q000517:prevention & control; D015164:Vaccines, Inactivated
D000953:Antigens, Protozoan; D015164:Vaccines, Inactivated; D016753:Interleukin-10; D007371:Interferon-gamma