title: Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: Initial results.
abstract: The purpose of our study was to investigate whether quantitative diffusion-weighted images (DWI) were useful for monitoring the therapeutic response of primary bone tumors. We encountered 18 osteogenic and Ewing sarcomas. Magnetic resonance (MR) images were performed in all patients before and after therapy. We measured the apparent diffusion coefficient (ADC) values, contrast-to-noise ratio (CNR), and tumor volume of the bone tumors pre- and posttreatment. We determined change in ADC value, change in CNR on T2-weighted images (T2WI), change in CNR on gadopentetate dimeglumine (Gd)-T1-weighted images (Gd-T1WI), and change in tumor volume. The bone tumors were divided into two groups: group A was comprised of tumors with less than 90% necrosis after treatment and group B of tumors at least with 90%. Changes in ADC value, tumor volume, and CNR were compared between the groups. Change in the ADC value was statistically greater in group B than that in the group A (p = 0.003). There was no significant difference in the changes in CNR on T2WI (p = 0.683), in CNR on Gd-T1WI (p = 0.763), and tumor volume (p = 0.065). The ADC value on DWI is a promising tool for monitoring the therapeutic response of primary bone sarcomas.
authors.affiliation: Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-0811, Japan. 1-doll@tb3.so-net.ne.jp
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Hayashida
authors.forename: Toshitake
authors.initials: T
authors.lastname: Yakushiji
authors.forename: Kazuo
authors.initials: K
authors.lastname: Awai
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Katahira
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Osamu
authors.initials: O
authors.lastname: Shimomura
authors.forename: Mika
authors.initials: M
authors.lastname: Kitajima
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hirai
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuta
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002648:Child; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology; D012512:Sarcoma, Ewing / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D019786:Gadolinium DTPA