Chromatin modulation and the DNA damage response.
The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.
Costelloe
Thomas
T
Genome Stability Laboratory, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway.
Fitzgerald
Jennifer
J
Murphy
Niall J
NJ
Flaus
Andrew
A
Lowndes
Noel F
NF
D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly; D004249:DNA Damage; D004260:DNA Repair; D006657:Histones / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008745:Methylation; D008957:Models, Genetic; D008958:Models, Molecular; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational
D002843:Chromatin; C468783:H2AX protein, human; D006657:Histones