5-Substituted-2,3-diphenyltetrahydrofurans: a new class of moderately selective COX-2 inhibitors.
The nature of C-5 substituent and the configuration at C-5 carbon of 2,3-diphenyltetrahydrofurans, with chiral centres at C-2, C-3 and C-5, show a remarkable influence on their COX-2 inhibition and selectivity. Out of the eight compounds investigated here, 1b with COOH group and R* configuration at C-5, and 2d with CH2SCH2CH3 group and S* configuration at C-5 have been identified as lead molecules for further studies on COX-2 inhibition.
Singh
Palwinder
P
Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. palwinder_singh_2000@yahoo.com
Mittal
Anu
A
Kaur
Satwinderjit
S
Kumar
Subodh
S
D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D052246:Cyclooxygenase 2 Inhibitors; D005663:Furans