[The sensitivity to ketoconazole of Candida strains isolated from the digestive tract ontocenoses in children].
The study included 52 children. During endoscopy the contents of oesophagus, stomach and duodenum were collected with catheters, and additionally washings from the oral cavity and anal swabs or samples of faeces. Materials were inoculated on Sabouraud's media. The axenic strains of fungi were identified using own methods and others tests (API 20C, API 20C AUX). The activity of ketoconazole (K) was measured against 100 strains of Candida: C. albicans (91 strains), C. kefyr (4), C. famata (2), C. tropicalis (1), C. guilliermondii (1), C. glabrata (1). The strains susceptibility to K (RO4 1400 Janssen) was estimated with the own system based on the dose-response curves; the minimal inhibitory concentration (MIC) values were canculated. The low values of MIC indicate high susceptibility to K of examined Candida strains.
Horwatt-Bozyczko
E
E
Katedra Biologii i Parazytologii Lekarskiej AM, 90-436 Lódź, Al. Kościuszki 85.
Kurnatowski
M
M
Wasowska-Królikowska
K
K
Kurnatowska
A
A
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D008826:Microbial Sensitivity Tests; D016533:Mycological Typing Techniques; D013045:Species Specificity
D000935:Antifungal Agents; D007654:Ketoconazole