title: Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response.
abstract: Cryptosporidiosis in young children prompts local inflammation in the intestinal tract. We studied a cohort of young children with cryptosporidiosis to determine whether systemic inflammatory responses occur and, if so, to evaluate whether inflammation persists after infection. Cryptosporidiosis was associated with increased levels of interleukin-8 and tumor necrosis factor- alpha systemically, which persisted at 6 months after enrollment. The level of intestinal tumor necrosis factor- alpha was elevated at enrollment, but elevated levels did not persist. Worsening of malnutrition, particularly stunting, was observed after infection. The association of cryptosporidiosis, inflammation, and stunting in children with cryptosporidiosis warrants further evaluation.
authors.affiliation: The University of Vermont College of Medicine, Department of Medicine, Unit of Infectious Diseases, Burlington, VT 05405, USA. beth.kirkpatrick@uvm.edu
authors.forename: B D
authors.initials: BD
authors.lastname: Kirkpatrick
authors.forename: Francine
authors.initials: F
authors.lastname: Noel
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Rouzier
authors.forename: Jan L
authors.initials: JL
authors.lastname: Powell
authors.forename: J W
authors.initials: JW
authors.lastname: Pape
authors.forename: Grylande
authors.initials: G
authors.lastname: Bois
authors.forename: W Kemper
authors.initials: WK
authors.lastname: Alston
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Larsson
authors.forename: Katherine
authors.initials: K
authors.lastname: Tenney
authors.forename: Cassandra
authors.initials: C
authors.lastname: Ventrone
authors.forename: Cheryl
authors.initials: C
authors.lastname: Powden
authors.forename: Meera
authors.initials: M
authors.lastname: Sreenivasan
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Sears
mesh_terms: D000953:Antigens, Protozoan / Q000097:blood; D015331:Cohort Studies; D003457:Cryptosporidiosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000097:blood / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood / Q000378:metabolism*
chemical_list: D000953:Antigens, Protozoan; D007378:Interleukins; D018124:Receptors, Tumor Necrosis Factor; D007371:Interferon-gamma