title: [Association between polymorphisms of XPD gene and susceptibility to chronic benzene poisoning].
abstract: OBJECTIVE
  To explore the relationship between genetic polymorphisms of XPD gene and susceptibility to chronic benzene poisoning.
  
  
  METHODS
  A case control study was conducted. Eighty patients diagnosed with chronic benzene poisoning and 62 workers occupationally exposed to benzene who were engaged in the same working time and job title as patients were investigated. PCR-RFLP was used for detecting the single nucleotide polymorphisms (SNPs) on codon156, codon312 and codon751 of XPD gene.
  
  
  RESULTS
  There was a 2.903 times (95% CI: 1.054 - 7.959, P = 0.039 2) increased risk of chronic benzene poisoning in the subjects carrying XPD 751Gln variant allele compared with those carrying XPD 751Lys/Lys genotype, after adjusted for sex, length of service, smoking and drinking status.
  
  
  CONCLUSIONS
  The subjects with XPD 751Gln variant allele are more susceptive to benzene.
authors.affiliation: Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Hui-long
authors.initials: HL
authors.lastname: Huang
authors.forename: Jian-ning
authors.initials: JN
authors.lastname: Xu
authors.forename: Quan-kai
authors.initials: QK
authors.lastname: Wang
authors.forename: Ya-wen
authors.initials: YW
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Gui-lan
authors.initials: GL
authors.lastname: Li
mesh_terms: D000483:Alleles; D001554:Benzene / Q000506:poisoning*; D016022:Case-Control Studies; D002908:Chronic Disease; D003062:Codon / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D003062:Codon; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human; D001554:Benzene