Large cell neuroendocrine carcinoma of the ampulla of Vater.
BACKGROUND
Neuroendocrine tumors of the ampulla of Vater are extremely rare, and few cases of large cell neuroendocrine carcinoma (LCNEC) of the ampulla have been reported.


METHODS
A 48-year-old male with obstructive jaundice was admitted to our hospital. On examination the patient was found to have a periampullary growth and subsequently underwent the Whipple's procedure.


RESULTS
Histopathological examination and immuno-histochemistry revealed features of LCNEC of the ampulla of Vater. The patient developed multiple liver metastases 6 months after Whipple's procedure.


CONCLUSIONS
LCNEC of the ampulla of Vater is rare and highly aggressive, with a dismal prognosis.
Selvakumar
Eswaran
E
Department of Pathology, Center for G.I.Bleeding & Division of Hepatobiliary Pancreatic Diseases, Government Stanley Medical College Hospital, the Tamilnadu Dr. M.G.R. Medical University, Chennai, Tamilnadu, India.
Vimalraj
Velayutham
V
Rajendran
Shanmugasundaram
S
Balachandar
Tirupporur G
TG
Kannan
Devy G
DG
Jeswanth
Satyanesan
S
Ravichandran
Palaniappan
P
Sundaram
Arunachalam
A
Surendran
Rajagopal
R
D014670:Ampulla of Vater / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011859:Radiography