Plasma glucose concentrations in profound neonatal hypoglycemia.
The study goal was to define low thresholds of plasma glucose concentrations that constitute profound hypoglycemia. Population analysis was performed on research publications on neonatal hypoglycemia ascertained by a Medline search. Eligible patients had neurological sequelae associated directly and primarily with hypoglycemia (profound hypoglycemia). Of 89 infants, more than 95% had plasma glucose levels of less than 25 mg/dL that were first detected at more than 10 hours of age. A breakdown of study patients according to those with or without neurological sequelae, who were exposed to a similar degree of hypoglycemia, showed a combined incidence of neurological injury of 21%, with 95% confidence interval from 14% to 27%.
Alkalay
Arie L
AL
Division of Neonatology, Department of Pediatrics, Ahmanson Pediatric Center, David Geffen School of Medicine, UCLA, Los Angeles, CA 90048, USA, and Division of Neurology, Department of Pediatrics, Alberta Children's Hospital, Calgary, Canada.
Flores-Sarnat
Laura
L
Sarnat
Harvey B
HB
Farber
Sergio J
SJ
Simmons
Charles F
CF
D001786:Blood Glucose / Q000032:analysis*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000150:complications; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology; D012016:Reference Values
D001786:Blood Glucose