Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries.
An efficient method for preparation of 4,6 or 5,6 disubstituted 3-aminopyridazines was easily carried out starting from easily available 4-bromo-pyridazine-3,6-dione, and using combination of both amination and Pd(0) cross-coupling reactions under microwave irradiation.
Schmitt
Martine
M
Laboratoire de Pharmacochimie de la Communication Cellulaire (UMR 7081), Faculté de Pharmacie, Université Louis Pasteur, Illkirch cedex, France. schmitt@pharma.u-strasbg.fr
de Araújo-Júnior
João X
JX
Oumouch
Said
S
Bourguignon
Jean-Jacques
JJ
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry*
D011724:Pyridazines; C513630:aminopyridazine; C062482:pyridazine; D010165:Palladium