title: Composition, enantiomeric distribution, and antibacterial activity of the essential oil of Achillea ligustica All. from Corsica.
abstract: The essential oil of Achillea ligustica from Corsica was investigated by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 82 compounds representing 94.0% of the oil were tentatively identified. The main constituents were the camphane derivatives, representing >30% (camphor, 21.3%; borneol, 6.2%; bornyl acetate, 3.5%) of the whole oil, and santolina alcohol (19.3%). The enantiomeric distribution of 8 chiral constituents was determined by GC-MS using two enantioselective stationary phases (DIME-beta-CD and Lipodex-E). Racemic santolina alcohol, required for optimization of the enantioselective GC conditions, was prepared by an original two-step synthesis from 2,5-dimethylhexa-2,4-diene. The whole essential oil was tested for its antibacterial activity against a wide range of bacteria using a paper disk method. The results show a promising activity against Streptomyces species.
authors.affiliation: LCMBA, UMR CNRS 6001, Université de Nice-Sophia Antipolis, Parc Valrose, F-06108 Nice Cedex 2, France. jfilippi@uni-hohenheim.de
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Filippi
authors.forename: Don-Antoine
authors.initials: DA
authors.lastname: Lanfranchi
authors.forename: Soizic
authors.initials: S
authors.lastname: Prado
authors.forename: Nicolas
authors.initials: N
authors.lastname: Baldovini
authors.forename: Uwe J
authors.initials: UJ
authors.lastname: Meierhenrich
mesh_terms: D031162:Achillea / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002849:Chromatography, Gas; D005602:France; D008401:Gas Chromatography-Mass Spectrometry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism; D013302:Streptomyces / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile