Tandem Diels-Alder cycloadditions of 2-pyrone-5-acrylates for the efficient synthesis of novel tetracyclolactones.
Readily prepared from the regioselective Pd-catalyzed coupling reactions of 3,5-dibromo-2-pyrone, 3-bromo-2-pyrone-5-carboxylates undergo tandem uninterrupted sequential Diels-Alder cycloaddition reactions with allyl vinyl ethers in a highly regio- and stereoselective fashion to provide a series of novel tetracyclolactones in good yields.
Chung
Soo-Im
SI
Department of Chemistry, Hanyang University, Seoul 131-791, Korea.
Seo
Joobeom
J
Cho
Cheon-Gyu
CG