title: Reduced atherosclerotic lesion size in P-selectin deficient apolipoprotein E-knockout mice fed a chow but not a fat diet.
abstract: P-selectin. We investigated the role of P-selectin on the development of vascular lesions in an ApoE(-/-) male mice. Double-knockout (ApoE(-/-), P-selectin(-/-); DKO) were compared to single-knockout (ApoE(-/-); SKO) mice. They were fed a chow or fat diet for 3, 6, 15, and 20 weeks, without any differences in cholesterol levels. DKO mice fed a chow diet exhibited a ratio of lesion area over media lower than SKO mice, for 3 (P < .03) , 6 (P < .001), and 15 (P < .02) weeks. DKO mice fed a fat diet showed a lower ratio only at 3 weeks. P-selectin deficiency in ApoE(-/-) mice has a protective effect in atherosclerotic lesions development. Reduction of lesion size depends on diet type and duration. A fat diet could neutralize the beneficial effects of P-selectin deficiency, inducing atherosclerotic lesions via probably other adhesion molecules.
authors.affiliation: EA-3740, INSERM-IFR62, Faculté de Médecine Laënnec, Université Claude Bernard Lyon 1, Lyon, France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Bourdillon
authors.forename: Jacques
authors.initials: J
authors.lastname: Randon
authors.forename: Lydie
authors.initials: L
authors.lastname: Barek
authors.forename: Kazem
authors.initials: K
authors.lastname: Zibara
authors.forename: Chantal
authors.initials: C
authors.lastname: Covacho
authors.forename: Robin N
authors.initials: RN
authors.lastname: Poston
authors.forename: Elza
authors.initials: E
authors.lastname: Chignier
authors.forename: John L
authors.initials: JL
authors.lastname: McGregor