Mitochondria and cancer: is there a morphological connection?
Mitochondria are key players in several cellular functions including growth, division, energy metabolism, and apoptosis. The mitochondrial network undergoes constant remodelling and these morphological changes are of direct relevance for the role of this organelle in cell physiology. Mitochondrial dysfunction contributes to a number of human disorders and may aid cancer progression. Here, we summarize the recent contributions made in the field of mitochondrial dynamics and discuss their impact on our understanding of cell function and tumorigenesis.
Alirol
E
E
Department of Cell Biology, University of Geneva, Genève, Switzerland.
Martinou
J C
JC
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*