Pharmacological options in resistent ovary syndrome and premature ovarian failure.
OBJECTIVE
To present methods of treating women in apparent ovarian failure to allow them to ovulate and conceive.


METHODS
Ethinyl estradiol was used to lower elevated serum follicle stimulating hormone (FSH) levels to restore down-regulated FSH receptors on the follicle. Ovulation and pregnancy rates were then determined. Aggressive progesterone (P) therapy in the luteal phase was also used. Lowering elevated serum FSH with gonadotropin releasing hormone agonists was also successful in inducing ovulation in these patients.


RESULTS
Several anecdotal studies have demonstrated that ethinyl estradiol therapy can induce ovulation in women in apparent menopause and achieve live births.


CONCLUSIONS
The advantage of ethinyl estradiol over other estrogens to induce ovulation in hypergonadotropic women is that it does not cross-react in the assay for serum estradiol and can allow detection of estradiol secretion by the follicle. Thus estrogen therapy is by far the most effective treatment.
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000568:Amenorrhea / Q000188:drug therapy; D003687:Dehydroepiandrosterone / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000819:agonists / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000097:blood; D006727:Hormone Antagonists / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy*
D000276:Adjuvants, Immunologic; D000305:Adrenal Cortex Hormones; D005300:Fertility Agents, Female; D006727:Hormone Antagonists; D019382:Human Growth Hormone; D003687:Dehydroepiandrosterone; D005640:Follicle Stimulating Hormone