Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice.
The effect of the aqueous leaf and seed extracts of Phyllanthus amarus at oral dose of 150, 300 and 600 mg/kg was investigated for their antidiabetic and anti-lipidemic potentials. The extract produced a dose-dependent decrease in the fasting plasma glucose and cholesterol, and reduction in weights in treated mice. The results suggest that the extract could be enhancing peripheral utilization of glucose but the mechanisms on how this works remain unclear.
Adeneye
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Department of Pharmacology, Lagos State University College of Medicine, P.M.B. 21266, Ikeja, Lagos, Nigeria. adeneye2001@yahoo.com
Amole
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Adeneye
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D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006937:Hypercholesterolemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D029803:Phyllanthus; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D012639:Seeds
D000924:Anticholesteremic Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D002784:Cholesterol