[Distribution of HLA-B allele polymorphism of 8962 Han population in Liaoning of China].
OBJECTIVE
To investigate the distribution of genetic polymorphism of HLA-B locus in Liaoning Han population.


METHODS
The technique of polymerase chain reaction-sequence specific primers (PCR-SSP) was adopted in genotyping a sample of 8962 unrelated healthy individuals collected from a Chinese Han population in Liaoning area. The allele frequency of HLA-B was calculated and was compared with the results from other population.


RESULTS
Thirty-four HLA-B alleles were detected. The more common HLA-B allele included B*15(14.42%), B*40(14.33%) and B*13(11.99%). The B*82 and B*83 were absent. Forty-nine HLA-B antigens were detected.


CONCLUSIONS
The HLA-B allele polymorphism distribution of Liaoning Han population exhibits its own characteristic and the difference from old south and north Han population in China.
Chen
Yang
Y
Blood Center of Liaoning Province, Shenyang, Liaoning 110044, P. R. China.
Li
Jian-ping
JP
D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005787:Gene Frequency; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*
D015235:HLA-B Antigens