title: Demonstration of lanthanum in liver cells by energy-dispersive X-ray spectroscopy, electron energy loss spectroscopy and high-resolution transmission electron microscopy.
abstract: The appearance of lanthanum in liver cells as a result of the injection of lanthanum chloride into rats is investigated by advanced transmission electron microscopy techniques, including electron energy loss spectroscopy and high-resolution transmission electron microscopy. It is demonstrated that the lysosomes contain large amounts of lanthanum appearing in a granular form with particle dimensions between 5 and 25 nm, whereas no lanthanum could be detected in other surrounding cellular components.
authors.affiliation: EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Schryvers
authors.forename: F
authors.initials: F
authors.lastname: Roels
authors.forename: P C
authors.initials: PC
authors.lastname: D'Haese
authors.forename: M E
authors.initials: ME
authors.lastname: De Broe
mesh_terms: D000818:Animals; D022781:Hepatocytes / Q000737:chemistry*; D007811:Lanthanum / Q000032:analysis*; D008247:Lysosomes / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D023421:Models, Animal; D051381:Rats; D013052:Spectrometry, X-Ray Emission; D046590:Spectroscopy, Electron Energy-Loss
chemical_list: D007811:Lanthanum