title: Platelet dysfunction during cardiopulmonary bypass assessed by a novel whole-blood aggregometer.
abstract: OBJECTIVE
  The purpose of this study was to assess perioperative platelet function with 2 types of monitors (a whole-blood aggregometer [WBA analyzer; Mebanix, Tokyo, Japan]) and the Sonoclot monitor [Sienco, Wheat Ridge, CO]) in patients undergoing hypothermic cardiopulmonary bypass (CPB).
  
  
  METHODS
  Prospective, observational study.
  
  
  METHODS
  Single-center study at a university hospital.
  
  
  METHODS
  Twenty-six patients who underwent coronary artery bypass grafting or valve replacement under hypothermic CPB without platelet transfusion or fresh frozen plasma administration.
  
  
  METHODS
  Blood sampling was performed at the following time periods: after anesthetic induction, after CPB, and on the first postoperative day. These samples were assessed with the WBA analyzer and the Sonoclot.
  
  
  RESULTS
  Significant attenuation of adenosine diphosphate-induced platelet aggregation was detected shortly after CPB by 2 WBA analyzer-derived parameters: a decrease in the filtration pressure rate and an increase in the platelet aggregatory threshold index. Platelet aggregation returned to the preoperative level on the next day. There was no correlation between the amount of postoperative mediastinal drainage and defects in platelet aggregation. On the other hand, time to peak obtained by the Sonoclot did not show any significant changes.
  
  
  CONCLUSIONS
  Whole-blood aggregation measured with the WBA analyzer detected transient platelet dysfunction shortly after CPB, whereas the Sonoclot was less sensitive to this change.
authors.affiliation: Department of Anesthesiology, Keio University School of Medicine, Tokyo, Japan. ykotake@sc.itc.keio.ac.jp
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kotake
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Ogawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Katori
authors.forename: Ryohei
authors.initials: R
authors.lastname: Serita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morisaki
authors.forename: Junzo
authors.initials: J
authors.lastname: Takeda
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D001791:Blood Platelet Disorders / Q000175:diagnosis* / Q000209:etiology; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests / Q000295:instrumentation*; D012680:Sensitivity and Specificity
chemical_list: D000244:Adenosine Diphosphate