A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease.
We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P=.007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.
Cooke
Graham S
GS
Wellcome Trust Centre for Human Genetics, Churchill Hospital, University of Oxford, Oxford, United Kingdom, OX3 7BN. grahamc@well.ox.ac.uk
Tosh
Kerrie
K
Ramaley
Patricia A
PA
Kaleebu
Pontiano
P
Zhuang
Joanna
J
Nakiyingi
Jessica S
JS
Watera
Christine
C
Gilks
Charles F
CF
French
Neil
N
Whitworth
James A G
JA
Hill
Adrian V S
AV
D018946:Chemokine CCL5 / Q000235:genetics*; D015331:Cohort Studies; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000235:genetics* / Q000401:mortality* / Q000503:physiopathology; D006720:Homozygote; D006801:Humans; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D016019:Survival Analysis; D016896:Treatment Outcome; D014454:Uganda
D018946:Chemokine CCL5