title: Reversible posterior leukoencephalopathy caused by azathioprine in systemic lupus erythematosus.
abstract: The authors report a case of systemic lupus erythematosus with posterior leukoencephalopathy who presented with headache, tonic-clonic seizure, loss of consciousness and bilateral loss of vision, after taking azathioprine for three weeks. The patient had hypertension with normal eye grounds. The brain CT showed a hypodensity lesion at both bilateral occipital lobes, mainly in the white matter The symptoms and follow-up MRI were improved after the control of hypertension and discontinuation of azathioprine.
authors.affiliation: Division of Allergy-Immunology-Rheumatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand. fching@kku.ac.th
authors.forename: Chingching
authors.initials: C
authors.lastname: Foocharoen
authors.forename: Somsak
authors.initials: S
authors.lastname: Tiamkao
authors.forename: Jiraporn
authors.initials: J
authors.lastname: Srinakarin
authors.forename: Nittaya
authors.initials: N
authors.lastname: Chamadol
authors.forename: Kittisak
authors.initials: K
authors.lastname: Sawanyawisuth
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine