Crossing cellular barriers using dendrimer nanotechnologies.
Dendrimers represent a class of polymers characterised by their well-defined structure, with a high degree of molecular uniformity and low polydispersity. They have found a wide-range of pharmaceutical applications; however, more recently, they have been shown to function as effective intracellular carriers for drugs. In addition, dendrimers have been shown to be capable of bypassing efflux transporters. A new generation of dendrimer-based delivery systems will enable the efficient transport of drugs across cellular barriers.
Najlah
Mohammad
M
School of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire, Preston, Lancashire PR1 2HE, UK.
D'Emanuele
Antony
A
D000818:Animals; D002463:Cell Membrane Permeability; D050091:Dendrimers / Q000008:administration & dosage*; D004337:Drug Carriers; D015195:Drug Design; D006801:Humans; D036103:Nanotechnology; D011073:Polyamines / Q000008:administration & dosage
D050091:Dendrimers; D004337:Drug Carriers; C104700:PAMAM Starburst; D011073:Polyamines