[The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion].
OBJECTIVE
To study the relationship between otitis media of effusion (OME) and allergy by investigating eosinophil cationic protein in middle ear effusion ( MECP), middle ear effusion IgE (MIgE) and serum eosinophil cationic protein (SECP).


METHODS
The specimens drawn from 31 patients of OME were tested with Uni-CAP-100 allergic antigen testing system for the MECP, IgE and SECP. The results then were analyzed by statistical methods.


RESULTS
MECP were found in all the effusion specimens of 31 patients, the average concentration of which was 56.88 microg/L. The MECP concentration level in nine specimens (28.1%) was significantly elevated. The average concentration of MIgE was 27.2 ku/L. The MIgE concentration level in three specimens (9.7%) was remarkably increased. There was a positive correlation between the MECP level and the MIgE level( P <0.05). The average concentration of SECP was 5.6 microg/L.


CONCLUSIONS
ECP exists in the middle ear effusion of OME. OME is an allergic inflammatory process more localized in middle ear itself in some patients. There may be a complicated allergic mechanism in OME.
Tian
Junhai
J
Department of Otolaryngology, the First Hospital of Hebei Medical University, Shijiazhuang, 050031, China. tianjunhai200@sina.com
Lu
Hong
H
Liu
Yanmei
Y
Sun
Changchun
C
Xue
Haitao
H
Meng
Wenxia
W
Liu
Huixin
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D004432:Ear, Middle / Q000378:metabolism; D047091:Eosinophil Granule Proteins / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000378:metabolism*; D055815:Young Adult
D047091:Eosinophil Granule Proteins; D007073:Immunoglobulin E