Clinical features of Japanese male patients with type 1 autoimmune hepatitis.
BACKGROUND
Recently, unusual patients with autoimmune hepatitis, such as male patients, have increased.


OBJECTIVE
To assess clinical feature of Japanese males with type 1 autoimmune hepatitis compared with females.


METHODS
We investigated consecutive 160 patients with type 1 autoimmune hepatitis, who consisted of 20 males and 140 females, with a median age of 55 (16-79) years.


RESULTS
Compared with females, males had a lower frequency of definite diagnosis according to the revised scoring system proposed by the International Autoimmune Hepatitis Group (40% vs. 85%) and lower serum levels of immunoglobulin G [1932 (1085-3850) mg/dL vs. 2624 (1354-6562) mg/dL]. However, they were similar in age, form of clinical onset, symptomatic concurrent autoimmune disease, human leucocyte antigen DR status and frequency of cirrhosis at the time of diagnosis. The normalization of serum alanine aminotransferase levels within 6 months after the introduction of corticosteroid treatment was lower in males compared with females (73% vs. 93%).


CONCLUSIONS
In male patients, a diagnosis of autoimmune hepatitis should be made carefully. In Japanese patients with a dominant frequency of human leucocyte antigen DR4, gender may affect the response to corticosteroid treatment.
Miyake
Y
Y
Department of Internal Medicine, Kurashiki Riverside Hospital, Kurashiki, Japan. miyakeyasuhiro@hotmail.com
Iwasaki
Y
Y
Sakaguchi
K
K
Shiratori
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000906:Antibodies / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D005260:Female; D006680:HLA Antigens / Q000097:blood; D019693:Hepatitis, Autoimmune / Q000208:ethnology / Q000473:pathology*; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology
D000906:Antibodies; D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D000410:Alanine Transaminase