Synthesis of imidazoles through the copper-catalyzed cross-cycloaddition between two different isocyanides.
The copper-catalyzed reaction between two different isocyanides produces the corresponding heteroaromatization products, imidazoles, in good yields. The reaction proceeds most probably through the activation of the sp3 C-H bond in the isocyanides by a copper catalyst, followed by a [3 + 2] cycloaddition between the cuprioisocyanide intermediates and arylisocyanides.
Kanazawa
Chikashi
C
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Kamijo
Shin
S
Yamamoto
Yoshinori
Y
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis*; D015394:Molecular Structure
D003486:Cyanides; D007093:Imidazoles; D003300:Copper