title: Timely diagnosis of MDR-TB under program conditions: is rapid drug susceptibility testing sufficient?
abstract: Timely diagnosis and effective, safe treatment are essential to reduce transmission and improve outcomes for patients with tuberculosis. Aside from laboratory methods, many programmatic factors influence the overall turnaround time (TAT) in diagnosing multidrug-resistant tuberculosis (MDR-TB). We measured each step in the overall TAT required for MDR-TB in two of five health districts of Lima, Peru. The total TAT, from initial sputum specimen to diagnosis and appropriate treatment, was 5 months, almost twice as long as the bacteriological procedures per se. Expensive investments in laboratory technology may yield low returns unless the programmatic aspects of the diagnostic process are streamlined at the same time.
authors.affiliation: Instituto Nacional de Salud, Lima, Perú.
authors.forename: M
authors.initials: M
authors.lastname: Yagui
authors.forename: M T
authors.initials: MT
authors.lastname: Perales
authors.forename: L
authors.initials: L
authors.lastname: Asencios
authors.forename: L
authors.initials: L
authors.lastname: Vergara
authors.forename: C
authors.initials: C
authors.lastname: Suarez
authors.forename: G
authors.initials: G
authors.lastname: Yale
authors.forename: C
authors.initials: C
authors.lastname: Salazar
authors.forename: M
authors.initials: M
authors.lastname: Saavedra
authors.forename: S
authors.initials: S
authors.lastname: Shin
authors.forename: O
authors.initials: O
authors.lastname: Ferrousier
authors.forename: P
authors.initials: P
authors.lastname: Cegielski
mesh_terms: D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D015986:Confounding Factors, Epidemiologic; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010568:Peru / Q000453:epidemiology; D012293:Rifampin / Q000627:therapeutic use; D013183:Sputum / Q000382:microbiology; D013997:Time Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000904:Antibiotics, Antitubercular; D007538:Isoniazid; D012293:Rifampin