title: Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase.
abstract: The design, synthesis, and unexpected inhibitory activity against S-adenosyl-homocysteine (SAH) hydrolase (SAHase, EC 3.3.1.1) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a Ki value of 5.0 microM against SAHase.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
authors.forename: Sylvester L
authors.initials: SL
authors.lastname: Mosley
authors.forename: Brian A
authors.initials: BA
authors.lastname: Bakke
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Sadler
authors.forename: Naresh K
authors.initials: NK
authors.lastname: Sunkara
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Dorgan
authors.forename: Zhaohui Sunny
authors.initials: ZS
authors.lastname: Zhou
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Seley-Radtke
mesh_terms: D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D007700:Kinetics; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011741:Pyrimidine Nucleosides; D043383:Adenosylhomocysteinase