[Biochemical and pharmacological mechanisms of different types of hypoxic preconditioning in cerebral ischemia in mice].
Different types of hypoxic preconditioning (hypoxic, circulatory, hemic and tissue hypoxia) increase the tolerance to complete global cerebral ischemia at early terms (hours). Biochemico-pharmacological analysis with the use of selective agonists and antagonists showed the importance of adenosine A1-receptors and K+(ATP)-channels in the mechanisms of the neuroprotective effect and natural tolerance. The general scheme of the investigated mechanisms of different types of hypoxic preconditioning has been proposed.
Kulinskiĭ
V I
VI
Gavrilina
T V
TV
Minakina
L N
LN
Kovtun
V Iu
VIu
D058907:Adenosine A1 Receptor Agonists; D058916:Adenosine A1 Receptor Antagonists; D000818:Animals; D002545:Brain Ischemia / Q000139:chemically induced / Q000473:pathology*; D003035:Cobalt; D005260:Female; D015640:Ion Channel Gating; D019194:Ischemic Preconditioning; D008297:Male; D051379:Mice; D009532:Nickel; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000819:agonists / Q000502:physiology*; D043682:Receptor, Adenosine A1 / Q000502:physiology*; D012977:Sodium Nitrite
D058907:Adenosine A1 Receptor Agonists; D058916:Adenosine A1 Receptor Antagonists; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D043682:Receptor, Adenosine A1; D003035:Cobalt; C022838:nickel chloride; D009532:Nickel; C018021:cobaltous chloride; D012977:Sodium Nitrite