title: [Lecithin-cholesterol acyltransferase gene 608C/T polymorphism associated with atherosclerotic cerebral infarction].
abstract: OBJECTIVE
  To explore the distribution of lecithin-cholesterol acyltransferase gene (LCAT) 608C/T polymorphism in Chinese Han population and the relationship of the polymorphism association with the occurrence of atherosclerotic cerebral infarction.
  
  
  METHODS
  The lecithin:cholesterol acyltransferase gene 608C/T polymorphism is identified by polymerase chain reaction (PCR), single-strand conformation polymorphism (SSCP)and restriction fragment length polymorphism (RFLP) in 150 patients with ACI and 122 healthy controls matching age and sex.
  
  
  RESULTS
  The distribution of LCAT 608C/T gene polymorphism was in accordance with Hardy-Weinberg equilibrium. The CT genotype frequency (14.0%) and T allele frequency (7.0%) in ACI group were significantly higher than those in control group (P<0.05). The concentration of high density lipoprotein cholesterol (HDL-C) in 608CC subgroups were significantly higher than those in 608CT subgroups both in ACI group and in control group (P<0.05).
  
  
  CONCLUSIONS
  The LCAT 608C/T polymorphism is possibly a predisposing factor in ACI happening of Chinese Han population. T allele frequency is possibly concerned with the metabolism of HDL-C.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China. zxysdjm@yahoo.com.cn
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Zhu
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Xu
authors.forename: Rong-yao
authors.initials: RY
authors.lastname: Hou
authors.forename: Heng-fang
authors.initials: HF
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
authors.forename: Xiao-su
authors.initials: XS
authors.lastname: Yang
authors.forename: Qi-dong
authors.initials: QD
authors.lastname: Yang
authors.forename: Bei-sha
authors.initials: BS
authors.lastname: Tang
mesh_terms: D000368:Aged; D000483:Alleles; D002544:Cerebral Infarction / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational / Q000235:genetics
chemical_list: D007862:Phosphatidylcholine-Sterol O-Acyltransferase