Attempts of modification of apoptosis in the course of experimental trichinellosis in mice.
The influence of the some immunomodulators (PHA-P, TFX and dexamethasone) on the process of apoptosis, occurring in the course of trichinellosis in mice, has been studied. It has been found that PHA-P activates this process in the jejunum mucosa and prolongs it in the muscular inflammatory infiltration, whereas TFX has no influence and dexamethasone distinctly decreases the level of the apoptotic cells. The number of the intestinal trichinae on the successive days of infection was similar in all groups of animals, however, the number of the muscular larvae in the groups receiving immunostimulators was much lower and in the group treated with dexamethasone--a little higher than that in control. As in mice receiving PHA-P and TFX, the cellular inflammatory infiltration in the muscles was larger than that in control, and in the group to which dexamethasone was administrated--smaller, the authors think that it was extensiveness of the infiltration and not the level of the apoptotic cells that influenced the number of the outliving larvae.
Karmańska
K
K
W. Stefańiski Institute of Parasitology, Polish Academy of Sciences 50-375 Wrocław, Norwida.
Piekarska
J
J
Widyma
A
A
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D007413:Intestinal Mucosa / Q000187:drug effects / Q000469:parasitology / Q000473:pathology; D007583:Jejunum / Q000187:drug effects / Q000473:pathology; D007814:Larva / Q000187:drug effects; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects / Q000469:parasitology / Q000473:pathology; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology* / Q000627:therapeutic use; D013949:Thymus Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D014234:Trichinella / Q000187:drug effects; D014235:Trichinellosis / Q000188:drug therapy / Q000473:pathology*
D007155:Immunologic Factors; D010835:Phytohemagglutinins; C019108:TFX; D013949:Thymus Extracts; C028784:phytohemagglutinin-P; D003907:Dexamethasone