Double cancer of gall bladder and bile duct not associated with anomalous junction of the pancreaticobiliary duct system.
BACKGROUND
Simultaneous double cancers of the biliary tract are rare. Most of them are thought to be associated with pancreaticobiliary maljunction (PBM); however, the characteristics of tumours without PBM are still unclear.


METHODS
Histology, immunoreactivity with carcinoembryonic antigen, carbohydrate antigen 19-9 and p53 and mutations in the K-ras gene were examined in tumours resected from cases of simultaneous double cancers of the biliary tract.


RESULTS
Four cases of simultaneous double cancers of the biliary tract were identified among 108 patients with biliary tract cancer (3.7%). None of the four cases associated with PBM, and the results of histological, immunohistochemical and genetic examinations differed between the bile duct and gall bladder cancers in each case.


CONCLUSIONS
Even when they do not associate with PBM, double cancers in the biliary tract are more likely to be the result of multicentric development.
Hori
Hiiroshige
H
Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Kobe, Japan.
Ajiki
Tetsuo
T
Fujita
Tsunenori
T
Okazaki
Taro
T
Suzuki
Yasuyuki
Y
Kuroda
Yoshikazu
Y
Fujimori
Takahiro
T
D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D001652:Bile Ducts / Q000473:pathology; D001659:Biliary Tract / Q000473:pathology; D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D011905:Genes, ras; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009378:Neoplasms, Multiple Primary; D010183:Pancreatic Ducts / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000097:blood
D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D016159:Tumor Suppressor Protein p53