title: Injection tongueplasty: effects of sclerosant OK-432 on rat tongue.
abstract: Our aim was to investigate the effect of sclerosant agent OK-432 on tongue fibrosis and to determine whether the fibrosis formed by this substance increases with dose. Fifty Wistar albino rats were divided into three groups for the study. In the first group 0.2 ml OK-432, in the second group 0.5 ml OK-432, and in the third group physiological saline as the control substance was injected into the tongue of these rats. Subjects were sacrificed on the first day, first week, first month, third month and sixth month following the injection. Cross-sections of the tongues were stained with hematoxylin-eosin (HE) and Masson Tri-chrome. The degree of fibrosis was measured using ocular micrometry. A significant amount of fibrosis was observed in both the 0.2 ml (P = 0.020) and 0.5 ml (P = 0.003) OK-432 injection groups. OK-432 is a material that causes significant fibrosis in the muscle when compared to physiological saline. The degree of fibrosis in the tongue increases with dose.
authors.affiliation: Otorhinolaryngology Department, Kocaeli University School of Medicine, Kocaeli, Turkey. gurkankeskin@yahoo.com
authors.forename: Gurkan
authors.initials: G
authors.lastname: Keskin
authors.forename: Sinem
authors.initials: S
authors.lastname: Keskin
authors.forename: Omer
authors.initials: O
authors.lastname: Aydin
authors.forename: Yesim
authors.initials: Y
authors.lastname: Gurbuz
authors.forename: Emre
authors.initials: E
authors.lastname: Ustundag
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005355:Fibrosis / Q000188:drug therapy* / Q000473:pathology; D007267:Injections; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D010844:Picibanil / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012597:Sclerosing Solutions / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D020181:Sleep Apnea, Obstructive / Q000188:drug therapy; D012913:Snoring / Q000601:surgery*; D014060:Tongue Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D012597:Sclerosing Solutions; D010844:Picibanil