Peritoneal adhesions: pathogenesis, assessment and effects.
BACKGROUND
As modem surgery has evolved, there has been an increase in iatrogenic peritoneal adhesions. Most surgeons manage adhesions and their related complications on a regular basis. Studies in recent years have improved the understanding of the pathogenesis and impact of adhesions, which are discussed.


METHODS
A systematic search of literature was performed to identify publications addressing the etiopathogenesis, clinical spectrum and effects of adhesions, using the following database: Medline (1966 to April 2005), Embase (1974 to April 2005), and the Cochrane controlled trials register. The reference lists of key publications so identified were in addition scrutinized for additional articles of relevance.


RESULTS
Adhesions occur in more than three fourths of patients following laparotomy. Perironeal trauma results in a unique inflammatory process in which fibrin formation and fibrinolysis play a central role. The effects of adhesions are unpredictable but are wide ranging, causing a significant health care burden. Intestinal obstruction, infertility, problems at reoperative surgery and cumulative costs of care over many years are the key concerns. While adhesiolysis is beneficial in adhesive intestinal obstruction and infertility, its value in chronic pain is uncertain.


CONCLUSIONS
Every violation of the peritoneum carries a potentially lifelong risk of a range of complications. Data available on the epidemiology and natural history of adhesions call for a wider acknowledgement of the problem in the planning of services and greater attention to preventive strategies.
Senthilkumar
M P
MP
Department of Surgery, Dumfries and Galloway Royal Infirmary, Dumfries, UK. sanskrity@hotmail.com
Dreyer
Jacob S
JS
D015746:Abdominal Pain / Q000209:etiology; D017281:Cost of Illness; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology; D017699:Pelvic Pain / Q000209:etiology; D010532:Peritoneal Diseases / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D000267:Tissue Adhesions