Short time exposure to hypoxia promotes H9c2 cell growth.
The effects of short time (15 min) exposure to hypoxia on rat cardiomyocytes (H9c2) were examined. Exposure to hypoxia inhibited cell death via activation of MEK/extracellular signal-regulated kinase (ERK). Further, exposure to hypoxia promoted cell growth by down-regulation of p27 and phosphorylation of cyclin-dependent kinase 2 (CDK2) and retinoblastoma protein (Rb).
Takahashi
Rie
R
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Kawawa
Akiyuki
A
Kubota
Shunichiro
S
D000818:Animals; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D015687:Cell Hypoxia; D002460:Cell Line; D049109:Cell Proliferation; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000378:metabolism; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051381:Rats; D016160:Retinoblastoma Protein / Q000378:metabolism; D013997:Time Factors
D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D016160:Retinoblastoma Protein; D017346:Protein Serine-Threonine Kinases; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases