[Effect of amaranth oil and intermittent hypoxic training on ultrastructural and metabolic changes in the liver induced by fluorine and low doses of radiation].
Ultrastructural and metabolic changes were studied during chronic fluorine intoxication and low doses of radiation (total dose is 1 Gr) in liver cells and tissues in rats fed with amaranth oil and treated with intermittent hypoxic training (IHT). The obtained data detected the ordered and compact position of mitochondria, peroxisomes, lipoprotein droplets with light electronic density, glycogen granules and also agranular endoplasmatic retuculum channels, which may be linked with reorganization of metabolic pathway of energy supply from fat acids via gluconeogenesis. Simultaneously the decrease of TBA-reactive substances accumulation with the considerable increase in activity of the antioxidant enzymes (catalase, glutathione peroxidase) and index of general antioxidant activity have been established. Therefore, the combined effect of IHT and amaranth oil on adequate occurence of free radical reactions provides the effective adaptation of organism to fluorine intoxication and ionizing radiation via the restoration of homeostasis on metabolic and ultrastructural levels. The obtained results allow to recommend IHT and amaranth oil for complex correction of changes, induced by fluorine intoxication and ionizing radiation.
Hzhehots'kyĭ
M P
MP
Konyk
U V
UV
Kozak
L P
LP
Kovalyshyn
V I
VI
D027721:Amaranthus / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004734:Energy Metabolism; D000860:Hypoxia / Q000503:physiopathology*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010938:Plant Oils / Q000494:pharmacology*; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D051381:Rats; D012969:Sodium Fluoride / Q000633:toxicity*; D013997:Time Factors
D000975:Antioxidants; D008054:Lipid Peroxides; D010938:Plant Oils; D012969:Sodium Fluoride