title: Malignant nonfunctioning islet cell tumor of the pancreas with intrasplenic growth: a case report.
abstract: BACKGROUND
  We reported a case of malignant nonfunction islet cell tumor (10.0 cm in diameter) of the pancreas, with malignant histological features and splenic infiltration. The case is rare, and few reports have been published.
  
  
  METHODS
  A 46-year-old woman with a vague pain in the left upper quadrant for 3 months was found to have a tumor in the spleen. Ultrasonography and computed tomography demonstrated a well-defined pancreatic tumor of 8.2 X 10.0 cm in size, her serum levels of pancreatic hormones were within normal limits.
  
  
  RESULTS
  Splenectomy combined with pancreatectomy was performed for the tail of the pancreas. Resected specimens showed a malignant nonfunctioning islet cell tumor invading the spleen.
  
  
  CONCLUSIONS
  The growth pattern of the tumor causes malignant features. Resection of the tumor should be performed by enucleation, pancreaticoduodenectomy or distal pancreatectomy.
authors.affiliation: Department of General Surgery, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. wanghj@mail.dlptt.ln.cn
authors.forename: Hong-Jiang
authors.initials: HJ
authors.lastname: Wang
authors.forename: Zuo-Wei
authors.initials: ZW
authors.lastname: Zhao
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Luo
authors.forename: Zhong-Yu
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D018273:Carcinoma, Islet Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary