title: [Preload and ventricular lusitropism; logistic and monoexponential function fittings].
abstract: A logistic function has been found to fit the isovolumic left ventricular (LV) relaxation pressure curve and the isometric relaxation force curve of the papillary muscle much more precisely than the conventional monoexponential function. Therefore, the logistic time constant (tauL) has been proposed as a better index of the rate of cardiac relaxation or lusitropism than the conventional monoexponential time constant (tauE). Many investigators have reported that tauE changes with preloading. We analysed and compared the effect of LV volume (LVV) loading on both logistic and monoexponential fittings and their time constants of the isovolumic LV relaxation pressure curve in the excised, cross-circulated canine hearts. We found that the logistic fitting was superior to the monoexponential fitting at any LVV. LVV loading did not affect tauL at all but affected tauE slightly. The logistic fitting more reliably characterises the lusitropism than the monoexponential fitting, and tauL, serving as a more reliable ventricular lusitropism index, is independent of changes in LVV loading or the Frank-Starling effect.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655.
authors.forename: Ju
authors.initials: J
authors.lastname: Mizuno
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hanaoka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suga
mesh_terms: D000758:Anesthesia; D000818:Animals; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D016015:Logistic Models; D009126:Muscle Relaxation; D010210:Papillary Muscles / Q000502:physiology; D013995:Time; D016277:Ventricular Function, Left / Q000502:physiology*