title: Organohalogen compounds in human breast milk from Republic of Buryatia, Russia.
abstract: Human breast milk samples collected during 2003/04 in Buryatia, a Russian autonomous republic, were analyzed in order to assess human exposure to organohalogen compounds including organochlorine pesticides, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs). When compared with available worldwide data, levels of HCB (23-880 ng/g lipid wt.), PCBs (69-680 ng/g lipid wt.), and HCHs (100-3700 ng/g lipid wt.) were relatively high, indicating elevated human exposure to these organochlorines (OCs) in Buryatia. In contrast to OCs, PBDE concentrations were low (0.46-1.7 ng/g lipid wt.). Out of 14 BDE congeners analyzed, BDE-28, BDE-47, BDE-100, BDE-153, BDE-197, and BDE-207 were detected. Estimated daily intakes (EDIs) of HCHs, HCB, CHLs, and PCBs by infants solely from human milk for 100%, 43%, 34%, and 17% of the samples, respectively, exceeded guideline thresholds. Although high EDIs raise concern for possible toxic effects of OCs, women in Buryatia are recommended to breastfeed due to numerous advantages of breastfeeding for mother and child.
authors.affiliation: Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
authors.forename: Oyuna V
authors.initials: OV
authors.lastname: Tsydenova
authors.forename: Agus
authors.initials: A
authors.lastname: Sudaryanto
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kajiwara
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kunisue
authors.forename: Valeriy B
authors.initials: VB
authors.lastname: Batoev
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tanabe
mesh_terms: D000328:Adult; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000032:analysis*; D005260:Female; D055768:Halogenated Diphenyl Ethers; D006581:Hexachlorobenzene / Q000032:analysis; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008423:Maternal Age; D008895:Milk, Human / Q000737:chemistry*; D010298:Parity; D010573:Pesticide Residues / Q000032:analysis*; D010647:Phenyl Ethers / Q000032:analysis; D011075:Polybrominated Biphenyls / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis; D011247:Pregnancy; D012426:Russia
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D006846:Hydrocarbons, Halogenated; D010573:Pesticide Residues; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; D006581:Hexachlorobenzene; C086401:pentabromodiphenyl ether; D011078:Polychlorinated Biphenyls