title: Cognitive and motor development of 8-year-old children born after ICSI compared to spontaneously conceived children.
abstract: BACKGROUND
  As a continuation of two large-scale, multicentre studies on the development of 5-year-old ICSI children, we present results of the follow-up study undertaken on the cognitive and motor development of 8-year-old ICSI children.
  
  
  METHODS
  Developmental outcomes of 151 8-year-old singletons born through ICSI after 32 weeks of gestation were compared with those of 153 singletons of the same age born after spontaneous conception (SC). Part of this population was seen in a cohort at the age 5 years. Outcome measures include Wechsler Intelligence Scale for Children-Revised (WISC-R) and Movement Assessment Battery for Children (ABC).
  
  
  RESULTS
  Regarding intellectual functioning, ICSI children tend to obtain significantly higher total (P < 0.01), verbal (P < 0.01) and performance (P < 0.05) intelligence scores than SC children, nevertheless remaining in similar ranges. These effects are small (Cohen's d < 0.50). High maternal educational level stayed in the regression as a factor accounting for some of the variance in total IQ between the groups. In terms of motor development, no significant differences were found between ICSI and SC children regarding overall motor skills, manual, balance and ball skills.
  
  
  CONCLUSIONS
  In this follow-up study, ICSI and SC children show a comparable cognitive and motor development until the age of 8 years.
authors.affiliation: Developmental and Lifespan Psychology, Centre for Medical Genetics, Vrije Universiteit Brussel, Brussels, Belgium. lize.leunens@vub.ac.be
authors.forename: L
authors.initials: L
authors.lastname: Leunens
authors.forename: S
authors.initials: S
authors.lastname: Celestin-Westreich
authors.forename: M
authors.initials: M
authors.lastname: Bonduelle
authors.forename: I
authors.initials: I
authors.lastname: Liebaers
authors.forename: I
authors.initials: I
authors.lastname: Ponjaert-Kristoffersen
mesh_terms: D001530:Belgium; D002648:Child; D002657:Child Development; D003071:Cognition; D004522:Educational Status; D005260:Female; D005306:Fertilization; D005865:Gestational Age; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D009043:Motor Activity; D013060:Speech; D020554:Sperm Injections, Intracytoplasmic; D014888:Wechsler Scales