title: Somatic DNA recombination in a mouse genomic region, BC-1, in brain and non-brain tissue.
abstract: The genomic region BC-1 (GenBank acc. No. AB075899) on mouse chromosome 16 has been reported as a genomic region undergoing somatic DNA recombination producing circular DNA and genomic deletion in brain during late embryogenesis. The present study shows that the BC-1 circular DNA production had already started on the 13th day of embryonic age, earlier than the previous observation that the circular DNA production started on the 15th through 17th embryonic day. The BC-1 deletion was also observed in the spleen and ocular lens. In situ hybridization analysis indicated that a human-homologous region in the BC-1 sequence was expressed in the lens at a perinatal period. These data suggest that the somatic DNA recombination in the BC-1 region is not restricted to brain tissue, and that the BC-1 DNA recombination relates to lens development.
authors.affiliation: Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Tsurumihara, Beppu, Oita, Japan. maedat@beppu.kyushu-u.ac.jp
authors.forename: Toyoki
authors.initials: T
authors.lastname: Maeda
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Mizuno
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sugano
authors.forename: Shinji
authors.initials: S
authors.lastname: Satoh
authors.forename: Junichi
authors.initials: J
authors.lastname: Oyama
authors.forename: Saburo
authors.initials: S
authors.lastname: Sakoda
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Naoki
authors.initials: N
authors.lastname: Makino
mesh_terms: D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D004270:DNA, Circular / Q000235:genetics / Q000378:metabolism*; D007908:Lens, Crystalline / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D004270:DNA, Circular