title: Metabolic alterations and neurodevelopmental outcome of infants with transposition of the great arteries.
abstract: Abnormal neurodevelopment has been reported for infants who were born with transposition of the great arteries (TGA) and underwent arterial switch operation (ASO). This study evaluates the cerebral metabolism of TGA infants at birth and before ASO and neurodevelopment 1 year after ASO. Proton magnetic resonance spectroscopy (1H-MRS) was performed on 16 full-term TGA brains before ASO within 3-6 days after birth. The brain metabolite ratios of [NAA/Cr], [Cho/Cr], and [mI/Cr] evaluated measured. Ten infants were evaluated at 1 year using the Bayley Scales of Infants Development II (BSED II). Cerebral metabolism of infants with TGA was altered in parietal white matter (PWM) and occipital gray matter (OGM) at birth before ASO. One year after ASO, [Cho/Cr] in PWM remained altered, but all metabolic ratios in OGM were normal. The results of BSID II at 1 year showed delayed mental and psychomotor development. This delayed neurodevelopmental outcome may reflect consequences of the altered cerebral metabolism in PWM measured by 1H-MRS. It is speculated that the abnormal hemodynamics due to TGA in utero may be responsible for the impaired cerebral metabolism and the subsequent neurodevelopmental deficit.
authors.affiliation: Division of Pediatric Cardiology, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: I Sook
authors.initials: IS
authors.lastname: Park
authors.forename: S Young
authors.initials: SY
authors.lastname: Yoon
authors.forename: J Yeon
authors.initials: JY
authors.lastname: Min
authors.forename: Y Hwue
authors.initials: YH
authors.lastname: Kim
authors.forename: J Kok
authors.initials: JK
authors.lastname: Ko
authors.forename: K Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: D Man
authors.initials: DM
authors.lastname: Seo
authors.forename: J Hee
authors.initials: JH
authors.lastname: Lee
mesh_terms: D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D002658:Developmental Disabilities / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D014188:Transposition of Great Vessels / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures