title: Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects.
abstract: Anabolic androgenic steroids (AAS) are doping agents that are mostly used for improvement of strength and muscle hypertrophy. In some sports, athletes reported that the intake of AAS is associated with a better recovery, a higher training load capacity and therefore an increase in physical and mental performances. The purpose of this study was to evaluate, the effect of multiple doses of AAS on different physiological parameters that could indirectly relate the physical state of athletes during a hard endurance training program. In a double blind settings, three groups (n = 9, 8 and 8) were orally administered placebo, testosterone undecanoate or 19-norandrostenedione, 12 times during 1 month. Serum biomarkers (creatine kinase, ASAT and urea), serum hormone profiles (testosterone, cortisol and LH) and urinary catecholamines (noradrenalin, adrenalin and dopamine) were evaluated during the treatment. Running performance was assessed before and after the intervention phase by means of a standardized treadmill test. None of the measured biochemical variables showed significant impact of AAS on physical stress level. Data from exercise testing on submaximal and maximal level did not reveal any performance differences between the three groups or their response to the treatment. In the present study, no effect of multiple oral doses of AAS on endurance performance or bioserum recovery markers was found.
authors.affiliation: Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland. norbaume@gmail.com
authors.forename: Norbert
authors.initials: N
authors.lastname: Baume
authors.forename: Yorck Olaf
authors.initials: YO
authors.lastname: Schumacher
authors.forename: Pierre-Edouard
authors.initials: PE
authors.lastname: Sottas
authors.forename: Carlo
authors.initials: C
authors.lastname: Bagutti
authors.forename: Michel
authors.initials: M
authors.lastname: Cauderay
authors.forename: Patrice
authors.initials: P
authors.lastname: Mangin
authors.forename: Martial
authors.initials: M
authors.lastname: Saugy
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000494:pharmacology*; D000728:Androgens / Q000494:pharmacology*; D000735:Androstenedione / Q000031:analogs & derivatives / Q000494:pharmacology; D015415:Biomarkers; D002395:Catecholamines / Q000652:urine; D004311:Double-Blind Method; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006728:Hormones / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010807:Physical Endurance / Q000187:drug effects*; D010809:Physical Fitness / Q000502:physiology; D012420:Running / Q000502:physiology; D013256:Steroids / Q000494:pharmacology*; D013315:Stress, Psychological / Q000097:blood* / Q000652:urine; D013739:Testosterone / Q000494:pharmacology
chemical_list: D045930:Anabolic Agents; D000728:Androgens; D015415:Biomarkers; D002395:Catecholamines; D006728:Hormones; D013256:Steroids; D019344:Lactic Acid; D013739:Testosterone; D000735:Androstenedione; C002828:19-norandrostenedione; D006854:Hydrocortisone