title: Paternal relatives and family history of breast cancer.
abstract: BACKGROUND
  Reported family medical history may be the most widely accessible genomics screen currently available. The worth of any population-screening tool may be measured by parameters such as sensitivity and specificity. There is some evidence and theory suggesting that family history of breast cancer may be more frequently communicated about maternal (versus paternal) lines. If true, a discrepancy in reporting family history of breast cancer could mean suboptimal accuracy for this genomics-screening tool.
  
  
  METHODS
  A cross-sectional analysis of reported family history of breast cancer was conducted beginning in early fall 2005 of data collected from April 2003 to March 2005. Study participants were Women's Health Clinic patients without breast cancer aged at least 40 years. The number of women reporting extended paternal relatives (e.g., aunts, grandmothers) with breast cancer was compared to the number of women reporting maternal relatives.
  
  
  RESULTS
  More women reported a maternal relative with breast cancer (16%) compared to those reporting paternal relatives (10%) (McNemar odds ratio = 1.71, 95% confidence interval = 1.26 to 2.34). A discrepancy remained in analyses adjusting for potential covariates (race/ethnicity, awareness of breast cancer, family communication about breast cancer, and perceived risk).
  
  
  CONCLUSIONS
  Self-reported family history of breast cancer may not optimally capture inherited risk from the father's side of the family. Further research is needed to look for modifiable contributors to this discrepancy to optimize screening for familial breast cancer.
authors.affiliation: Department of Human Genetics, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298-0037, USA. jmquilli@vcu.edu
authors.forename: John M
authors.initials: JM
authors.lastname: Quillin
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Ramakrishnan
authors.forename: Joseph
authors.initials: J
authors.lastname: Borzelleca
authors.forename: Joann
authors.initials: J
authors.lastname: Bodurtha
authors.forename: Deborah
authors.initials: D
authors.lastname: Bowen
authors.forename: Diane
authors.initials: D
authors.lastname: Baer Wilson
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D008487:Medical History Taking; D012737:Sex Factors; D011795:Surveys and Questionnaires