[Deep vein thrombosis and pulmonary embolism in a patient with multiple myeloma treated with thalidomide and dexamethasone].
A 51-year-old man visited our hospital because of fever in 2003. With the discovery of the presence of a chest wall tumor, pleural effusion and M-protein, and increased plasma cells in the bone marrow, a diagnosis of multiple myeloma was established. Since the effect of combination chemotherapy followed by tandem auto-PBSCT lasted only one year, thalidomide and dexamethasone administration was started in November 2004. However, three months later, his lower limbs became swollen. Elevation of fibrin degradation product (FDP) and computed tomography findings suggested deep vein thrombosis and pulmonary embolism. With heparin and warfarin, these thromboses disappeared. Furthermore, chemotherapy strategies in addition to thalidomide were safely performed with anti-coagulation therapy. As thalidomide has become an accepted component in therapeutic strategies for multiple myeloma, careful attention must be paid to the prevention of thrombosis.
Miyazawa
Yuri
Y
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine.
Irisawa
Hiroyuki
H
Uchiumi
Hideki
H
Saitoh
Takayuki
T
Handa
Hiroshi
H
Matsushima
Takafumi
T
Tsukamoto
Norifumi
N
Karasawa
Masamitsu
M
Murakami
Hirokazu
H
Nojima
Yoshihisa
Y
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy*; D011655:Pulmonary Embolism / Q000209:etiology*; D013792:Thalidomide / Q000008:administration & dosage*; D020246:Venous Thrombosis / Q000209:etiology*
D020533:Angiogenesis Inhibitors; D018931:Antineoplastic Agents, Hormonal; D013792:Thalidomide; D003907:Dexamethasone