title: A case of cutaneous T cell pseudolymphoma in a patient with Helicobacter pylori infection.
abstract: Cutaneous pseudolymphomas (CPL) are benign cutaneous lymphoproliferative infiltrations of various origin, including among others bacterial infections, viral infections and drugs . Helicobacter pylori has been frequently founded in the stomach of patients with MALT lymphoma. In January 2001, a 43-year-old man was referred to our department because of a 1-month history of itchy erythematous patches, plaques and flat tumors on his body. Histological examination revealed nodular infiltrations composed of lymphocytes, plasma cells and histiocytes with exocytosis of lymphocytes within the epidermis. Molecular analysis of rearrangement of T cell receptor and immunoglobulin heavy-chain genes did not reveal monoclonality. Based on these clinical, laboratory and histopathological data, a diagnosis of cutaneous T cell pseudolymphoma (CTPL) was made. The patient was anti-H. pylori antibody-positive, and was treated with anti-H. pylori combination with the result that all of the tumors had disappeared by January 2002. The patient has maintained complete response up to the last follow-up visit in December 2005.
authors.affiliation: Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Mitani
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nagatani
authors.forename: Zenro
authors.initials: Z
authors.lastname: Ikezawa
authors.forename: Natsue
authors.initials: N
authors.lastname: Kakemizu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Michiko
authors.initials: M
authors.lastname: Aihara
authors.forename: Akinori
authors.initials: A
authors.lastname: Nozawa
authors.forename: Naohiko
authors.initials: N
authors.lastname: Tomita
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000382:microbiology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D019310:Pseudolymphoma / Q000150:complications* / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial