Collective dynamics of interacting molecular motors.
The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N> or approximately 5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events.
Campàs
O
O
Institut Curie, UMR CNRS 168, 26 rue d'Ulm 75248 Paris Cedex 05, France.
Kafri
Y
Y
Zeldovich
K B
KB
Casademunt
J
J
Joanny
J-F
JF
D003198:Computer Simulation; D016547:Kinesins / Q000737:chemistry*; D008954:Models, Biological; D008956:Models, Chemical; D020409:Molecular Motor Proteins / Q000737:chemistry*; D009038:Motion
D020409:Molecular Motor Proteins; D016547:Kinesins