Structure-activity relationship study of asiatic acid derivatives for new wound healing agent.
Ten semi-synthetic derivatives of asiatic acid were prepared and their wound healing effects were evaluated by employing a tensile strength assay and a wound area assay. Among them, ethoxymethyl 2-oxo-3,23-isopropylidene-asiatate (12) showed the strongest and the fastest wound healing activity. Furthermore, it left the smallest scar after healing.
Jeong
Byeong-Seon
BS
College of Pharmacy, Seoul National University, Seoul 151-742, Korea. ddongmak@naver.com
D000287:Administration, Topical; D000818:Animals; D002921:Cicatrix / Q000517:prevention & control; D062109:Dermatologic Surgical Procedures; D005260:Female; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013329:Structure-Activity Relationship; D013718:Tensile Strength; D013997:Time Factors; D014315:Triterpenes / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D014945:Wound Healing
D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C017032:asiatic acid