Neurotensin: role in psychiatric and neurological diseases.
Neurotensin (NT), an endogenous brain-gut peptide, has a close anatomical and functional relationship with the mesocorticolimbic and neostriatal dopamine system. Dysregulation of NT neurotransmission in this system has been hypothesized to be involved in the pathogenesis of schizophrenia. Additionally, NT containing circuits have been demonstrated to mediate some of the mechanisms of action of antipsychotic drugs, as well as the rewarding and/or sensitizing properties of drugs of abuse. NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction.
Cáceda
Ricardo
R
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Suite 4000 WMRB, 101 Woodruff Circle, Atlanta, GA 30322 4990, USA. rcaceda@emory.edu
Kinkead
Becky
B
Nemeroff
Charles B
CB
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001519:Behavior / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D009422:Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D009496:Neurotensin / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology; D018028:Receptors, Neurotensin / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000503:physiopathology; D009435:Synaptic Transmission
D014150:Antipsychotic Agents; D018028:Receptors, Neurotensin; D009496:Neurotensin; D004298:Dopamine