title: Long-term retention of dye after indocyanine green-assisted internal limiting membrane peeling.
abstract: OBJECTIVE
  To evaluate dye retention in the fundus after indocyanine green (ICG)-assisted internal limiting membrane peeling.
  
  
  METHODS
  Ten eyes with stage 3 or 4 nondiabetic idiopathic macular hole (MH group) and six eyes with diffuse diabetic macular edema (DM group) were studied. The fundus was examined with 780-nm infrared illumination by a scanning laser ophthalmoscope (SLO) after ICG-assisted internal limiting membrane peeling. The postoperative follow-up period ranged from 6 to 12 months (mean+/-SD, 3.7+/-2.6 months).
  
  
  RESULTS
  Fluorescence from ICG was detected in all studied eyes in both groups up to 6 months after surgery. At 9 months after surgery, ICG fluorescence was visible in all eyes of the DM group, but in only one-third of eyes of the MH group. No fluorescence was detected in fellow eyes that had not been operated on.
  
  
  CONCLUSIONS
  The present study using SLO revealed that ICG remains in the fundus for over 6 months after surgery. The results also suggested that a longer time might be required for dye clearance from the diabetic retina than from the nondiabetic retina.
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan. ma-kou@t-gh.bias.ne.jp.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ashikari
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Ozeki
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tomida
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakurai
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Tamai
authors.affiliation: Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ogura
mesh_terms: D000368:Aged; D004396:Coloring Agents / Q000493:pharmacokinetics*; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008269:Macular Edema / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods; D012167:Retinal Perforations / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D014821:Vitrectomy / Q000379:methods*; D014822:Vitreous Body / Q000378:metabolism* / Q000601:surgery / Q000648:ultrastructure
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green