A novel antiproliferative agent, phenylpyridineylbutenol, isolated from Streptomyces sp.
A novel compound showing antiproliferative effect was isolated from Streptomyces sp. Its structure was determined based on the interpretation of the NMR spectra, and its conformation was elucidated using molecular modeling and 2D NOESY. It was determined to be (E)-4-phenyl-3-(pyridine-2-yl)but-2-en-1-ol.
Shin
Choonshik
C
Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
Lim
Haeyoung
H
Moon
Sangik
S
Kim
Seunghyun
S
Yong
Yeonjoong
Y
Kim
Bum-Joon
BJ
Lee
Chul-Hoon
CH
Lim
Yoongho
Y
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000440:Butanols / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013302:Streptomyces
D000970:Antineoplastic Agents; D000440:Butanols; D011725:Pyridines