Long-term stability of relationships between reference materials for thromboplastins.
Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and must be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. ERM-AD149 (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relationship between ERM-AD149 and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multicentre studies (n = 11 and n = 9, respectively). No significant changes were observed in the relationships between these reference materials when all results were included (5% significance level).
Linsinger
Thomas P J
TP
EC-JRC, Institute for Reference Materials and Measurements, Geel, Belgium. thomas.linsinger@ec.europa.eu
van den Besselaar
Anton M H P
AM
Tripodi
Armando
A
D000818:Animals; D001780:Blood Coagulation Tests / Q000295:instrumentation* / Q000379:methods* / Q000592:standards; D002138:Calibration; D002417:Cattle; D006801:Humans; D007391:International Cooperation; D019934:International Normalized Ratio; D015233:Models, Statistical; D011517:Prothrombin Time / Q000295:instrumentation* / Q000379:methods* / Q000592:standards; D011817:Rabbits; D012015:Reference Standards; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D013925:Thromboplastin / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism
D013925:Thromboplastin