Koebnerizing sclerodermatous graft-versus-host disease caused by donor lymphocyte infusion and interferon-alpha.
Graft-versus-host disease (GvHD) is a common sequel to allogeneic bone marrow transplants, which may be accompanied by desirable graft-versus-tumour effects. Sclerodermatous GvHD is a rare subtype that is very difficult to treat. We report the first case of sclerodermatous GvHD as part of the Koebner phenomenon. We propose that donor lymphocyte infusion and interferon-alpha were involved in the pathogenesis of this case.
White
J M L
JM
Department of Dermatology, King's College Hospital, Denmark Hill, London SE5 9RS, UK. jonathanmlwhite@hotmail.com
Devereux
S
S
Pagliuca
A
A
Salisbury
J R
JR
du Vivier
A W P
AW
Creamer
D
D
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology; D006086:Graft vs Host Disease / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D017710:Lymphocyte Transfusion / Q000009:adverse effects*; D008297:Male; D012594:Scleroderma, Localized / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology
D000970:Antineoplastic Agents; D016898:Interferon-alpha