title: Ratio of oleic to palmitic acid is a dietary determinant of thrombogenic and fibrinolytic factors during the postprandial state in men.
abstract: BACKGROUND
  The nature of dietary fats affects the postprandial activation of the hemostatic system.
  
  
  OBJECTIVE
  We investigated whether the ratio of oleic to palmitic acid [and that of monounsaturated to saturated fatty acids (MUFA:SFA)] in the diet affects postprandial concentrations of triacylglycerols, tissue factor (TF), fibrinogen, tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor 1 (PAI-1).
  
  
  METHODS
  We studied the effects of diets enriched in olive oil (ROO), high-palmitic sunflower oil (HPSO), butter, or a mixture of vegetable and fish oils (VEFO) on circulating concentrations of the aforementioned factors in 14 healthy men. The fats had ratios of oleic to palmitic acid (MUFA:SFA) of 6.83 (5.43), 2.36 (2.42), 0.82 (0.48), and 13.81 (7.08).
  
  
  RESULTS
  The largest and longest-lasting postprandial changes in plasma triacylglycerol concentrations were found with the butter-based diet (all P < 0.05). No correlation was observed between the net incremental area under the curve (netAUC) for triacylglycerol and the ratio of oleic to palmitic acid (or MUFA:SFA) in the dietary fats. The netAUCs for TF and PAI-1, however, were inversely related to the ratio of oleic to palmitic acid (and MUFA:SFA) in ROO, HPSO, butter, and VEFO. Similar results were found for the fibrinogen netAUC when VEFO was omitted from the analysis. The netAUC for t-PA was inversely correlated with postprandial concentrations of triacylglycerol.
  
  
  CONCLUSIONS
  Postprandial concentrations of TF, fibrinogen, and PAI-1 are associated with the ratio of oleic to palmitic acid (MUFA:SFA) in dietary fats. The postprandial t-PA response is related to postprandial concentrations of triacylglycerol.
authors.affiliation: Cellular and Molecular Nutrition, Instituto de la Grasa, Seville, Spain.
authors.forename: Yolanda M
authors.initials: YM
authors.lastname: Pacheco
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bermúdez
authors.forename: Sergio
authors.initials: S
authors.lastname: López
authors.forename: Rocío
authors.initials: R
authors.lastname: Abia
authors.forename: José
authors.initials: J
authors.lastname: Villar
authors.forename: Francisco J G
authors.initials: FJ
authors.lastname: Muriana
mesh_terms: D000328:Adult; D019540:Area Under Curve; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000378:metabolism; D004791:Enzyme Inhibitors; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D019301:Oleic Acid / Q000008:administration & dosage* / Q000378:metabolism; D019308:Palmitic Acid / Q000008:administration & dosage* / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D010960:Plasminogen Activators / Q000378:metabolism; D019518:Postprandial Period; D012307:Risk Factors; D013925:Thromboplastin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control; D014280:Triglycerides / Q000097:blood*
chemical_list: D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D004791:Enzyme Inhibitors; D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides; D019301:Oleic Acid; D019308:Palmitic Acid; D005340:Fibrinogen; D013925:Thromboplastin; D010960:Plasminogen Activators