[Changes in lymph circulation in rats with experimental disseminated intravascular coagulation].
OBJECTIVE
To explore changes in lymph circulation in rats with experimental disseminated intravascular coagulation (DIC).


METHODS
Thirty-two male Wistar rats were randomly divided into two groups: DIC group and sham-operation group, with 16 rats in each group.In each group, 8 rats were used to observe the lymphatic circulation of intestinal mesentery, and the others were used to observe lymphatic dynamics. Experimental DIC model was replicated by injecting dextran 500 via jugular vein in Wistar rats. The changes in lymph circulation were observed in these rats with lymphology methods.


RESULTS
During the phase of DIC, the contractility of mesenteric micro-lymphatic (ML), the intestinal lymph flux, lymphocytes output were obviously decreased, and there was a few monocytes in the lymph fluid, but the lymph fluid viscosity was increased. After treatment with normal saline (NS), the contractility of ML, the intestinal lymph flux, lymphocytes output were obviously increased, and there was a large amount of monocytes in the lymph fluid, with significant difference compared with sham-operation group (all P<0.05). Moreover, the lymph fluid viscosity was decreased compared with sham-operation group (P<0.05).


CONCLUSIONS
The disturbance in lymph circulation mainly includes depression of contractility of lymphatics, the transport function of lymph circulation, and increased lymph fluid viscosity.
Li
Fu-long
FL
The Laboratory of Microcirculation and Critical Care, Hebei North University, Zhangjiakou 075000, Hebei, China. lifulong8915833@163.com
Liu
Yan-kai
YK
Niu
Chun-yu
CY
Du
Shu-ting
ST
Jiang
Hua
H
Zhao
Zi-gang
ZG
D000818:Animals; D003911:Dextrans / Q000633:toxicity; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000503:physiopathology*; D007700:Kinetics; D008196:Lymph / Q000502:physiology*; D008208:Lymphatic System / Q000503:physiopathology*; D042601:Lymphatic Vessels / Q000503:physiopathology; D008297:Male; D008643:Mesentery / Q000503:physiopathology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D003911:Dextrans