title: [Management of bone lesions in multiple myeloma].
abstract: Bone destruction is a key feature of multiple myeloma, which causes significant impairment of patients' activity. Some of the mechanisms regulating bone destruction have recently been clarified, and the management of bone diseases in myeloma patients has made considerable progress. Moreover,imaging techniques for screening bone lesions have been developed, such as PET scan or (99m)Tc scan, other than regular X-ray analysis. We describe here strategies for the management of bone disease in myeloma, e.g., ( I ) effective chemotherapy against myeloma cells, (II) decrease of osteoclasts by bisphosphonates, (III) surgical treatment of damaged bone, (IV) irradiation to lytic bone lesion and (V) other forms of supportive care. All of these approaches should be effectively integrated to improve the quality of life of myeloma patients.
authors.affiliation: Dept. of Hematology, Kumamoto University Hospital.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hata
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mitsuya
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001847:Bone Diseases / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D001862:Bone Resorption / Q000175:diagnosis; D001842:Bone and Bones / Q000000981:diagnostic imaging; D003131:Combined Modality Therapy; D004164:Diphosphonates / Q000627:therapeutic use*; D015775:Fractures, Stress / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy*; D049268:Positron-Emission Tomography; D011859:Radiography
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates