Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis.
OBJECTIVE
To determine any possible adverse effect of 1-deamino 8-D-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis.


METHODS
Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray.


RESULTS
No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy.


CONCLUSIONS
Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time.
Akoğlu
Ertap
E
Mustafa Kemal University, Faculty of Medicine, Department of Oto-Rhino-Laryngology, Head and Neck Surgery, 31100 Antakya, Hatay, Turkey. ertapakoglu@yahoo.com
Görür
Sadik
S
Atik
Esin
E
Okuyucu
Semsettin
S
Sangün
Ozlem
O
D000281:Administration, Intranasal; D000293:Adolescent; D050034:Antidiuretic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002923:Cilia / Q000187:drug effects / Q000648:ultrastructure; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009079:Mucociliary Clearance / Q000187:drug effects*; D009297:Nasal Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D053206:Nocturnal Enuresis / Q000188:drug therapy*
D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin