Interaction between nociceptin/orphanin FQ (N/OFQ) and GABA in response to feeding.
Nociceptin/orphanin FQ (N/OFQ) and gamma aminobutyric acid (GABA) agonists have been shown to increase feed intake in mammals and birds. In this study, the effect of intracerebroventricular (icv) injection of the potent NOP receptor agonists Nociceptin (1-13) NH(2), the GABA(A) receptor antagonist bicuculline, and the GABA(A) receptor agonist muscimol on feed intake in cockerels was investigated. The icv injection of N/OFQ and muscimol increases feed intake. The effect of N/OFQ on feed intake was strongly blocked by the injection of bicuculline whereas the effect of muscimol was stimulated by N/OFQ. These results suggest that N/OFQ may act at GABA(A) receptors or increases overflow of GABA in the brain of chickens to stimulate feeding.
Tajalli
S
S
Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman (SBUK), 76169-133 Kerman, Iran.
Jonaidi
H
H
Abbasnejad
M
M
Denbow
D M
DM
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D002645:Chickens; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D018847:Opioid Peptides / Q000819:agonists / Q000494:pharmacology / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology*; D000097629:Nociceptin
D001640:Bicuculline; D018755:GABA Agonists; D018756:GABA Antagonists; D009118:Muscimol; D018847:Opioid Peptides; D010446:Peptide Fragments; D005680:gamma-Aminobutyric Acid; D000097629:Nociceptin; C439964:nociceptin (1-13) amide