title: [Oxidative stress and hypertensive arteriopathy in children with primary hypertension--preliminary results].
abstract: Hypertensive arteriopathy and intima-media (IMT) thickening is observed already in adolescents with primary hypertension (PH) at diagnosis. The injury of arterial wall may cause also generation of free radicals and free radicals may by itself perpetuate arterial wall injury. The aim of the study was to verify the hypothesis that children with PH are exposed to oxidative injury (Sox) due to impaired antioxidant barrier, and that markers of Sox correlate with IMT and metabolic risk factors of arteriosclerosis.
  
  
  METHODS
  controlled, cross-sectional.
  
  
  METHODS
  76 children with untreated PH, aged 14.7 yrs (5-20): 23 girls, 53 boys.
  
  
  METHODS
  83 healthy children aged 13.4 yrs (4-23): 44 girls, 39 boys.
  
  
  METHODS
  Sono-graphic assessment of IMT in common carotid (cIMT) and superficial femoral arteries (cIMT). Sox was assessed as thiobarbituric acid reactive substances plasma concentration (TBARS), glutathione plasma concentration (GSH) as well as, glutathione peroxidase activity (GPX) were tested to demonstrate free radical scavenger activity.
  
  
  RESULTS
  PH pts had greater cIMT (p<0.0001), carotid wall cross sectional area (WCSA) (p<0.0001), fIMT (p<0.0001), lower HDL-cholesterol, apoA1/apoB than control group (p<0.05). GSH and GPX did not differ between groups but TBARS was significantly greater in PH pts (p <0.05). In control group fIMT significantly correlated with hCRP (r=0.30, p<0.01), homocysteine (r=0.3, p< 0.05), apoA1 (r=-0.2417, p<0.05), TBARS (r=0.329, p<0.01), GPX (r=-0.241, p<0.05) and with GSH (r=-0.22, p=0.05). In pts group, there were similar correlations between fIMT and hCRP (r=0.29, p<0.05), apoA1/apoB (r=-0.28, p<0.05).
  
  
  CONCLUSIONS
  PH pts are exposed to significantly higher Sox than controls. The significant correlations between markers of Sox and biochemical parameters suggest that hypertensive arteriopathy is an effect of complex interplay between Sox, metabolic and hemodynamic insults.
authors.affiliation: Instytut Pomnik-Centrum Zdrowia Dziecka.
authors.forename: Joanna
authors.initials: J
authors.lastname: Sladowska
authors.forename: Aldona
authors.initials: A
authors.lastname: Wierzbicka
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Litwin
authors.forename: Jolanta
authors.initials: J
authors.lastname: Antoniewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Niemirska
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Wawer
authors.forename: Piotr
authors.initials: P
authors.lastname: Socha
authors.forename: Ewa
authors.initials: E
authors.lastname: Skorupa
authors.forename: Ryszard
authors.initials: R
authors.lastname: Grenda
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D018384:Oxidative Stress; D012016:Reference Values; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D017540:Tunica Media / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase; D005978:Glutathione