Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma.
We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations.
van Dijk
B A C
BA
Department of Epidemiology, NUTRIM, Maastricht University, PO Box 616, Maastricht 6200 MD, The Netherlands.
Schouten
L J
LJ
Oosterwijk
E
E
Hulsbergen-van de Kaa
C A
CA
Kiemeney
L A L M
LA
Goldbohm
R A
RA
Schalken
J A
JA
van den Brandt
P A
PA
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics*
D051794:Von Hippel-Lindau Tumor Suppressor Protein