Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B.
Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepatitis B e antigen-positive HBV infection is associated with a significant reduction in peripheral blood monocyte expression of Toll-like receptor 2, a key component of innate immunity, thereby providing a mechanism by which wild-type HBV may establish persistent infection.
Riordan
Stephen M
SM
Gastrointestinal and Liver Unit, Prince of Wales Hospital, Barker Street, Randwick 2031, New South Wales, Australia. sriordan@ozemail.com.au
Skinner
Narelle
N
Kurtovic
Jelica
J
Locarnini
Stephen
S
Visvanathan
Kumar
K
D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000276:immunology / Q000494:pharmacology; D015536:Down-Regulation; D005260:Female; D006515:Hepatitis B virus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000956:Antigens, Viral; D018950:Lipopolysaccharide Receptors; D051195:Toll-Like Receptor 2; D014409:Tumor Necrosis Factor-alpha