Chimerism in a child with severe combined immunodeficiency: a case report.
Severe combined immunodeficiency (SCID) represents a group of rare, sometimes fatal, congenital disorders in which there is a combined absence of T-lymphocyte and B-lymphocyte function. Children with SCID die within two years of age, if untreated. The effective treatment for SCID is a hematopoietic stem cell transplantation (HSCT). It has been repeatedly described that in peripheral blood of infants with SCID maternal T cells can be found. Here we report a case of blood chimerism in a one-year-old boy with SCID.
Aureli
Anna
A
C.N.R. Institute for Organ Transplantation and Immunocytology, L'Aquila and Rome Sections, L'Aquila, Italy. a.aureli@itoi.cnr.it
Piancatelli
Daniela
D
Monaco
Palmina I
PI
Ozzella
Giuseppina
G
Canossi
Angelica
A
Piazza
Antonina
A
Isacchi
Giancarlo
G
Caniglia
Maurizio
M
Adorno
Domenico
D
D000483:Alleles; D046528:Chimerism; D006801:Humans; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D016511:Severe Combined Immunodeficiency / Q000235:genetics*