[Analysis of the function of vascular endothelial cells in coronary heart disease patients of blood-stasis syndrome].
OBJECTIVE
To explore the function of vascular endothelial cell (VEC) in patients with coronary heart disease (CHD) of Xin-blood-stasis syndrome.


METHODS
Some vasoactive substances produced by VEC were detected and analyzed in patients with CHD of or without Xin blood stasis syndrome in group A (n=112) and group B (n=108) respectively, also in patients with non-CHD but of Xin-blood-stasis syndrome in group C (n=110), and healthy persons in group D (n=100), including nitric oxide (NO), endothelin (ET), angiotensin H (Ag II), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule -1 (sVCAM-1).


RESULTS
The abnormality degree of ET, Ag II , sICAM-1 and sVCAM-1 in various groups showed such a tendency as group A> group B> group D (P < 0.01 or P < 0.05), while no significant difference in these criteria between group A and group C was shown (P > 0.05).


CONCLUSIONS
The vasoactive substances secreted by VEC are closely related to the formation and progression of CHD, and are likely to be important pathological markers of blood-stasis syndrome in CHD.
Yuan
Zhao-kai
ZK
Hunan University of TCM, Changsha. yuanzk1520@yahoo.com.cn
Huang
Xian-ping
XP
Tan
Guang-bo
GB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003937:Diagnosis, Differential; D042783:Endothelial Cells / Q000378:metabolism / Q000502:physiology*; D016232:Endothelins / Q000378:metabolism; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*
D016232:Endothelins; D018799:Intercellular Adhesion Molecule-1; D009569:Nitric Oxide