Asymmetric multicomponent [C+NC+CC] synthesis of highly functionalized pyrrolidines catalyzed by silver(I).
[reaction: see text] Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective Ag(I)-catalyzed asymmetric [C+NC+CC] coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines for both target- and diversity-oriented syntheses.
Garner
Philip
P
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, USA. ppg@case.edu
Kaniskan
H Umit
HU
Hu
Jieyu
J
Youngs
Wiley J
WJ
Panzner
Matthew
M