title: A chromosomal event resulting in possession and expression of multiple HLA-B and Cw genes in a renal patient.
abstract: Routine HLA typing of a renal patient for purposes of registration for transplantation revealed an unusual human leucocyte antigen (HLA)-B and Cw genotype, with three specificities detected. Results were confirmed in a second sample, and in a second laboratory. The possibility of these results reflecting a chimaeric state was rejected following short tandem repeat (STR) analysis. Although cytogenetic analysis has failed to detect a chromosomal abnormality, these findings support the view that the aberrant expression of HLA in this patient resulted from an unequal crossover event, occurring during meiosis in a previous generation.
authors.affiliation: Transplant Immunology Laboratory, St James's University Hospital, Beckett Street, Leeds, West Yorkshire, UK. katherine.poole@leedsth.nhs.uk
authors.forename: K
authors.initials: K
authors.lastname: Poole
authors.forename: B
authors.initials: B
authors.lastname: Montague
authors.forename: R
authors.initials: R
authors.lastname: Roberts
authors.forename: J
authors.initials: J
authors.lastname: Stoves
authors.forename: N
authors.initials: N
authors.lastname: Bendukidze
authors.forename: B
authors.initials: B
authors.lastname: Clark
mesh_terms: D046528:Chimerism; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008540:Meiosis; D008875:Middle Aged; D020080:Tandem Repeat Sequences / Q000235:genetics
chemical_list: D015235:HLA-B Antigens; D015236:HLA-C Antigens