title: An 18-case outbreak of drug-resistant Pseudomonas aeruginosa bacteriemia in hematology patients.
abstract: We retrospectively identified an outbreak of 18 episodes of P. aeruginosa bacteriemia in 17 patients with hematologic malignancies in 2004. All strains were ticarcillin I/R, 77% ciprofloxacin I/R, 72% ceftazidime I/R, 72% amikacin I/R and 50% imipenem I/R. The outbreak was multiclonal. Colistin was employed for documented therapy in ten cases including seven in which it was the only active drug. Outcomes were resolution of infection in 12 out of 18 episodes (67%), and death in six cases, five (25%) of which were attributable to the infection. Colistin was useful even in highly resistant strains and the efficacy of antibacterial therapy was similar (57%)in bacteriemia due to strains only susceptible to colistin.
authors.affiliation: Service des Maladies du Sang, CHRU, Lille, France.
authors.forename: Jean Baptiste
authors.initials: JB
authors.lastname: Micol
authors.forename: Stéphane
authors.initials: S
authors.lastname: de Botton
authors.forename: Romain
authors.initials: R
authors.lastname: Guieze
authors.forename: Valérie
authors.initials: V
authors.lastname: Coiteux
authors.forename: Stéphane
authors.initials: S
authors.lastname: Darre
authors.forename: Rodrigue
authors.initials: R
authors.lastname: Dessein
authors.forename: Olivier
authors.initials: O
authors.lastname: Leroy
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yakoub-Agha
authors.forename: Bruno
authors.initials: B
authors.lastname: Quesnel
authors.forename: Francis
authors.initials: F
authors.lastname: Bauters
authors.forename: Gilles
authors.initials: G
authors.lastname: Beaucaire
authors.forename: Serge
authors.initials: S
authors.lastname: Alfandari
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000453:epidemiology / Q000401:mortality; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D019337:Hematologic Neoplasms / Q000150:complications / Q000382:microbiology*; D006801:Humans; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D011550:Pseudomonas aeruginosa; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents