title: A novel HLA-A*0119 allele of a Caucasian family containing a mutation in a highly conserved region.
abstract: A novel human leucocyte antigen (HLA)-A (HLA-A*0119) allele has been identified in two individuals of a Caucasian family from Middle Europe using a single-allele-specific sequencing strategy. This allele is identical to the HLA-A*0101 allele except for one point mutation in the highly conserved codon 92 (TCT --> GCT) resulting in an amino acid change from serine to alanine.
authors.affiliation: Institute of Medical Immunology, Interbranch HLA-Laboratory, Martin Luther University Halle-Wittenberg, Halle, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Schlaf
authors.forename: A
authors.initials: A
authors.lastname: Wahle
authors.forename: B
authors.initials: B
authors.lastname: Seliger
authors.forename: W W
authors.initials: WW
authors.lastname: Altermann
mesh_terms: D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D005091:Exons; D005190:Family; D005260:Female; D015234:HLA-A Antigens / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007951:Leukemia, Myeloid; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D044465:White People / Q000235:genetics
chemical_list: D015234:HLA-A Antigens