title: Immunohistochemical distribution of amyloid deposits in 25 cows diagnosed with systemic AA amyloidosis.
abstract: The distribution of amyloid deposits was histopathologically and immunohistochemically examined in 25 cows aged 5 to 10 years that had been diagnosed with systemic AA amyloidosis. This examination revealed that amyloid deposits were also present in the hypophysis, ovary, uterus, mammary gland and skeletal muscle, in addition to the liver, kidney, spleen, pancreas, thyroid gland, adrenal gland, gastrointestinal mucosa, heart, lung and lymph nodes. The examined cows tended to have chronic inflammations, including chronic mastitis (six cases) or chronic pneumonia (four cases), which is thought of as a causative agent of AA amyloidosis. In contrast, five cases did not exhibit any chronic inflammation.
authors.affiliation: National Institute of Animal Health, Tsukuba, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamada
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kotani
authors.forename: Kikuyasu
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Horiuchi
authors.forename: Takuya
authors.initials: T
authors.lastname: Doi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Norihiro
authors.initials: N
authors.lastname: Sato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kanno
authors.forename: Takane
authors.initials: T
authors.lastname: Matsui
mesh_terms: D000375:Aging; D000682:Amyloid / Q000302:isolation & purification*; D000686:Amyloidosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology; D010053:Ovary / Q000473:pathology; D010902:Pituitary Gland / Q000473:pathology
chemical_list: D000682:Amyloid