Sensing by bacterial regulatory systems in host and non-host environments.
Free-living organisms have the ability to gauge their surroundings and modify their gene expression patterns in ways that help them cope with new environments. Here we discuss the physiological significance of recent reports describing the ability of the Salmonella typhimurium PhoP/PhoQ two-component system to recognize and respond to host-derived antimicrobial peptides.
Groisman
Eduardo A
EA
Department of Molecular Microbiology, Washington University School of Medicine, Campus P.O. Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. groisman@borcim.wustl.edu
Mouslim
Chakib
C
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D012486:Salmonella typhimurium / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction
D023181:Antimicrobial Cationic Peptides; D001426:Bacterial Proteins; C079792:PhoQ protein, Bacteria; C061064:PhoP protein, Bacteria