title: [Analysis of the factors affecting the recurrence of giant cell tumor of bone].
abstract: OBJECTIVE
  To analyze the clinical factors affecting the recurrence of giant cell tumors (GCT) of bone.
  
  
  METHODS
  The complete data of 146 cases with GCT were reviewed. Thirteen clinical factors were analyzed by chi(2) analysis. And the related Campanacci's grade system and Jaffe's grade system was analyzed by Crosstabs analysis. Multipal factors were analyzed by Logistic regression analysis.
  
  
  RESULTS
  Nineteen of 146 cases recurred, and recurrence rate was 13.0%. Recurrence rates of curettage and enblock resection groups were 18.8% and 6.3% respectively. And recurrence rates of curettage with or without of extensive procedure were 12.9% and 38.9%. Five cases had lung metastasis, and two cases presented with malignant transformation. The metastasis rate and the rate of malignant transformation were 3.4% and 1.4% respectively. The two factors of surgery method and burst out of bone-envelope appearance were related with the recurrence. Moreover, Logistic regression revealed that the surgery method significantly affected the recurrence. And Campanacci's grade system and Jaffe's grade system were not related to each other.
  
  
  CONCLUSIONS
  Surgery method is the main factor affected the recurrence of GCT, and Campanacci's grade system or Jaffe's grade system has no prognostic value.
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Qian-chen
authors.initials: QC
authors.lastname: Guo
authors.forename: Jing-nan
authors.initials: JN
authors.lastname: Shen
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.forename: Chang-ye
authors.initials: CY
authors.lastname: Zou
authors.forename: Song
authors.initials: S
authors.lastname: Jin
authors.forename: Jun-qiang
authors.initials: JQ
authors.lastname: Yin
authors.forename: Wei-ming
authors.initials: WM
authors.lastname: Liao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery; D005163:Factor Analysis, Statistical; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000601:surgery; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D012307:Risk Factors