Oligomeric interaction between ryanodine receptors: potential role in Ca(2+) release.
Receptor proteins in both eukaryotic and prokaryotic cells often form regular lattice or array in the membrane. Recent theoretical analyses indicate that such arrays may provide a novel mechanism for receptor signaling regulation in cells. The functional coupling between neighboring receptors could improve the signaling performance. The ryanodine receptors (RyR)/calcium release channels usually form 2-D regular lattice in the endoplasmic/sarcoplasmic reticulum membranes. Thus, RyR is a potentially good model to study the function of receptor 2-D array. In this article, we briefly review recent progresses in this research field, including RyR-RyR interaction, RyR array's function and working mechanisms. The investigations performed by new methods in our laboratory are summarized. We demonstrate that the RyR-RyR interaction is modulated by the functional states of RyRs. Accordingly, the mechanism of "dynamic coupling" of RyR array is proposed. Its possible role in RyR-mediated Ca(2+) release is discussed.
Hu
Xiao-Fang
XF
College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. xfhu@sjtu.edu.cn
Zhu
Pei-Hong
PH
Hu
Jun
J
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002412:Cations; D006801:Humans; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D020239:Receptor Cross-Talk / Q000502:physiology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D002412:Cations; D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium