title: [An autopsy case of obliterative bronchiolitis associated with Stevens-Johnson syndrome].
abstract: We reviewed an autopsied 27-year-old female with obliterative bronchiolitis associated with Stevens-Johnson syndrome. She had a history of Stevens-Johnson syndrome at age 10 years old and was treated with corticosteroids. Two months after the onset of dermatitis, the patient complained of dyspnea on exertion. The chest radiograph showed hyperinflation, and pulmonary function tests revealed obstructive impairment. The respiratory failure progressed due to respiratory tract infection and pneumothorax. She underwent thoracoscopic cyst surgery for right pneumothorax. Although the patient was clinically diagnosed as having obliterative bronchiolitis and received corticosteroids therapy and mechanical ventilation, she died of progressive respiratory failure 17 years after the onset of Stevens-Johnson syndrome. On autopsy, the macroscopic appearance of both lungs showed multiple white nodules in the centrilobular lesion corresponding to the obliteration of the small bronchioli. The microscopic appearance revealed constrictive bronchiolitis in the membranous bronchioli of both lungs associated with secondary bronchiectasis caused by superimposed infection.
authors.affiliation: Department of Respiratory Medicine, Toho University School of Medicine.
authors.forename: Keishi
authors.initials: K
authors.lastname: Sugino
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kimura
authors.forename: Go
authors.initials: G
authors.lastname: Sano
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Kato
authors.forename: Keigo
authors.initials: K
authors.lastname: Takagi
authors.forename: Kayoko
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Akira
authors.initials: A
authors.lastname: Hebisawa
authors.forename: Koichiro
authors.initials: K
authors.lastname: Nakata
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects; D001989:Bronchiolitis Obliterans / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D013902:Radiography, Thoracic; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000150:complications*
chemical_list: D000658:Amoxicillin