title: Schizophrenia: new pathological insights and therapies.
abstract: The neurodevelopmental hypothesis of schizophrenia posits an interaction between multiple susceptibility genes and one or more environmental insults in early life, resulting in altered brain development and the emergence of psychosis in early adulthood. Based on this framework, it has been argued that most neuropathological deficits observed in post mortem and neuroimaging studies of schizophrenia represent one or more lesions that originated in early life and remained static thereafter. However, recent longitudinal neuroimaging studies demonstrate a progressive component to the neuropathology of new-onset schizophrenia. This opens the possibility that the functional decline seen in many patients following the onset of illness may be halted or slowed. This review provides an update on developments in research on the neuropathology of schizophrenia and discusses recent advances in antipsychotic treatment and the potential impact on long-term outcomes.
authors.affiliation: Department of Psychiatry, Schizophrenia Research Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, USA. jarskog@med.unc.edu
authors.forename: L Fredrik
authors.initials: LF
authors.lastname: Jarskog
authors.forename: Seiya
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Lieberman
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology*; D015259:Dopamine Agents / Q000627:therapeutic use*; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D014150:Antipsychotic Agents; D015259:Dopamine Agents