title: Regression rate of clinical HPV infection of the lower genital tract during pregnancy after laser CO2 surgery.
abstract: The objective of the study was to evaluate the effects of laser CO2 surgery during pregnancy to prevent clinical HPV infection recurrence after delivery and vertical infection. A case-control study was performed on 280 pregnant women affected by clinical HPV infection treated during pregnancy with 256 women treated three months after delivery. Follow-up was performed for a minimum of three colposcopic examinations for two years. Recurrence rates were calculated considering the number of positive findings for at least one colposcopic examination confirmed by biopsy after a negative control in a year. Statistical comparison of rates was performed by chi-squared and Fisher's exact test. Recurrence rates were higher in the women treated in postpartum (p < .01) than in the group treated during gestation (p < .005). Clinical HPV infections treated during the second trimester of pregnancy showed a sensitive decrease in recurrence-rate of infection. Rarity of respiratory papillomatosis makes conclusions inconsistent for the prevention of vertical infection.
authors.affiliation: Department of Gynecology, Perinatology and Childhealth, University La Sapienza of Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Frega
authors.forename: E
authors.initials: E
authors.lastname: Baiocco
authors.forename: S
authors.initials: S
authors.lastname: Pace
authors.forename: A
authors.initials: A
authors.lastname: Palazzo
authors.forename: R
authors.initials: R
authors.lastname: Iacovelli
authors.forename: A
authors.initials: A
authors.lastname: Biamontil
authors.forename: M
authors.initials: M
authors.lastname: Moscarini
authors.forename: P
authors.initials: P
authors.lastname: Stentella
mesh_terms: D002245:Carbon Dioxide; D003218:Condylomata Acuminata / Q000601:surgery* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D005831:Genital Diseases, Female / Q000601:surgery* / Q000821:virology; D006801:Humans; D053685:Laser Therapy; D049590:Postpartum Period; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000601:surgery*; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012008:Recurrence; D019233:Retreatment / Q000706:statistics & numerical data
chemical_list: D002245:Carbon Dioxide