Successful in utero treatment of chronic and massive fetomaternal hemorrhage with fetal hydrops.
BACKGROUND
Massive fetomaternal hemorrhage is an uncommon cause of chronic fetal anemia. Without treatment, hydrops fetalis can occur and progress toward death. In some cases, an early diagnosis can improve the management.


METHODS
A patient was found to have a fetus with non-immune hydrops related to massive and early fetomaternal hemorrhage successfully treated with serial fetal intravascular transfusion. After the treatment, ultrasonographic signs of hydrops disappeared and the pregnancy resulted in a good fetal outcome. There was no need for neonatal transfusion. Neurological examination at 1 month post-natal was normal.


CONCLUSIONS
When massive fetomaternal hemorrhage is diagnosed early in the pregnancy, serial fetal intravascular transfusion may be an alternative to immediate delivery.
Rubod
Chrystèle
C
Clinique de Gynécologie-Obstétrique, Hôpital Jeanne de Flandre, CHRU de Lille, France.
Houfflin
Véronique
V
Belot
Franck
F
Ardiet
Emmanuel
E
Dufour
Philippe
P
Subtil
Damien
D
Deruelle
Philippe
P
D000328:Adult; D001805:Blood Transfusion, Intrauterine; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005324:Fetal Movement; D005331:Fetomaternal Transfusion / Q000150:complications* / Q000175:diagnosis; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016216:Ultrasonography, Prenatal
D006454:Hemoglobins