[Use of aminoglycoside antibiotic gentamycin in extremely premature infants--administration schedule and suggested dosage based on pharmacokinetic studies in plasma].
The pharmacokinetics of Gentamycin administered to 22 infants intravenously at currently recommended doses (2-2.5 mg every 24 h for infants less than 7 days of life and 28 g.a. and 12 h for infants 32 g.a). The results showed a statistically significant relation between half-life and postconsiptional age and direct correlation between total body clearance and postconsiptional age. These pharmacokinetics data were used to calculate a new dosage schedule for preterm infants. Ondoing therapeutic drug monitoring is essential to tailor the dosage to the individual patient. Gentamycin.
Slŭncheva
B
B
Emilova
Z
Z
Vakrilova
L
L
Pramatarova
T
T
Popivanova
A
A
Svinarov
D
D
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005839:Gentamicins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate
D000900:Anti-Bacterial Agents; D005839:Gentamicins