title: Recording of high V1-V3 precordial leads may be essential to the diagnosis of Brugada syndrome during the ajmaline test.
abstract: Sodium channel-blocking agents are routinely used to unveil the Brugada syndrome in patients in whom the typical electrocardiographic pattern is absent or doubtful. In this article, the authors report a patient with syncopal episodes of unknown origin in whom the conventional electrocardiographic result was normal and a negligibly small "saddle back" type repolarization was present in lead V2 recorded 2 intercostal spaces above the conventional site. Intravenous ajmaline (50 mg) did not elicit the type 1 pattern of the Brugada syndrome in the precordial leads obtained at their usual level, but a clear-cut coved-type repolarization was apparent in high right precordial leads. These findings indicate that high precordial leads should be routinely recorded while assessing the ajmaline test in patients suspected of having the Brugada syndrome.
authors.affiliation: Division of Cardiology, Hospital General de Agudos Jose M. Ramos Mejia, General Urquiza 609, C1221ADC Buenos Aires, Argentina.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Teijeiro
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Garro
authors.forename: Rafael S
authors.initials: RS
authors.lastname: Acunzo
authors.forename: Ernesto
authors.initials: E
authors.lastname: Albino
authors.forename: Pablo A
authors.initials: PA
authors.lastname: Chiale
mesh_terms: D000328:Adult; D000404:Ajmaline; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000235:genetics; D017147:Defibrillators, Implantable; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D026941:Sodium Channel Blockers; D013575:Syncope / Q000209:etiology; D013577:Syndrome; D014672:Vectorcardiography
chemical_list: D000889:Anti-Arrhythmia Agents; D026941:Sodium Channel Blockers; D000404:Ajmaline