title: Central nervous system metastases of pulmonary adenocarcinoma mimicking neurofibromatosis type 2.
abstract: We report a case of a 51-year-old man presenting with rapidly progressive unilateral tinnitus, hearing loss and imbalance. Neuroimaging revealed bilateral VIIIth cranial nerve masses and multiple cerebral and spinal cord lesions that were interpreted as being acoustic schwannomas and multiple meningeomas. An initial tentative diagnosis of neurofibromatosis type 2 (NF2) was made. Both clinical and radiological evolution were atypical for NF2 and the initial diagnosis of NF2 was questioned. Additional technical investigations demonstrated a pulmonary adenocarcinoma. Postmortem examination confirmed that this patient had multiple central nervous system metastases of a primary pulmonary adenocarcinoma, presenting clinically and neuroradiologically as a probable neurofibromatosis type 2. Clinicians should be aware of the rare possibility of central nervous system metastases mimicking NF2.
authors.affiliation: Department of Neurology, Middelheim Hospital, ZNA, Antwerp, Belgium.
authors.forename: B M P
authors.initials: BM
authors.lastname: Willekens
authors.forename: S
authors.initials: S
authors.lastname: Rooker
authors.forename: G
authors.initials: G
authors.lastname: Dua
authors.forename: B
authors.initials: B
authors.lastname: Appel
authors.forename: J J
authors.initials: JJ
authors.lastname: Martin
authors.forename: R
authors.initials: R
authors.lastname: Crols
authors.forename: P P
authors.initials: PP
authors.lastname: De Deyn
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D016518:Neurofibromatosis 2 / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011859:Radiography