title: Gastrinoma: sporadic and familial disease.
abstract: The physiologic sequelae of a gastrinoma can be well controlled with medical therapy. The role of surgery has shifted from managing acid hyper-secretion and ulcer complications to preventing metastatic disease and managing symptomatic metastases. With improved methods of imaging for the detection of occult gastrinomas, the prospective evaluation of the role for surgery in altering the natural history of these tumors is now possible.
authors.affiliation: Tumor Angiogenesis Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, CRC 4-5940, 10 Center Drive, Bethesda, MD 20892, USA. libuttis@mail.nih.gov
authors.forename: Steven K
authors.initials: SK
authors.lastname: Libutti
authors.forename: H Richard
authors.initials: HR
authors.lastname: Alexander
mesh_terms: D000465:Algorithms; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D015408:Gastrinoma / Q000175:diagnosis / Q000503:physiopathology / Q000556:secondary / Q000601:surgery; D005755:Gastrins / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis / Q000401:mortality
chemical_list: D005755:Gastrins