Type I CD36 deficiency associated with metabolic syndrome and vasospastic angina: a case report.
A 54-year-old man was admitted to our hospital for evaluation of chest pain occurring at rest in the morning. ST segment depression was observed during a treadmill exercise test. Coronary angiography identified spontaneous spasm of the proximal right coronary artery, and right coronary obstruction was improved from 90% to about 50% stenosis after intracoronary administration of nitroglycerin. Myocardial iodine-123 beta-methyl-p-iodophenyl-pentadecanoic acid uptake was absent, but thallium-201 uptake during single photon emission computed tomography was normal, and neither platelet nor monocyte expression of the CD36 molecule was observed, indicating type I CD36 deficiency. High blood pressure, elevated plasma triglyceride and fasting plasma glucose levels, and low high-density lipoprotein values suggested metabolic syndrome. The final diagnosis was type I CD 36 deficiency associated with metabolic syndrome and vasospastic angina.
Kamiya
Masataka
M
First Department of Internal Medicine, Nippon Medical School, Sendagi 1-1-5, Bunkyo-ku, Tokyo 113-8603.
Nakagomi
Akihiro
A
Tokita
Yukichi
Y
Yasutake
Masahiro
M
Kusama
Yoshiki
Y
Takayama
Morimasa
M
Takano
Teruo
T
D000788:Angina Pectoris, Variant / Q000276:immunology* / Q000503:physiopathology; D018955:CD36 Antigens / Q000378:metabolism*; D003329:Coronary Vasospasm / Q000276:immunology*; D004562:Electrocardiography; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D024821:Metabolic Syndrome / Q000276:immunology*; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon
D018955:CD36 Antigens; D007457:Iodine Radioisotopes; D007462:Iodobenzenes