[A study on HLA-DQB1 allele associated with genetic susceptibility to duodenal ulcer in Guangdong Hans].
OBJECTIVE
To study the genetic susceptibility of HLA-DQB1 alleles to duodenal ulcer in Chinese Hans from Guangdong area around.


METHODS
Hundred and five patients with duodenal ulcer and hundred and five healthy controls were examined for HLA-DQB1 genotypes. HLA-DQB1 allele typing was carried out by polymerase chain reaction with sequence specific primers (PCR-SSP).


RESULTS
The allele frequency of HLA-DQB1*0602 in patients with duodenal ulcer (64.8%) was significantly higher than that in healthy controls (14.3%).


CONCLUSIONS
These findings suggest that HLA-DQB1*0602 is a susceptible gene to duodenal ulcer in Guangdong Hans of China. And at HLA-DQB1 site, there are immunogenetic differences between duodenal ulcer patients and healthy controls.
Du
Yi-ping
YP
Digestive Department of Shenzhen Hospital of Beijing University, Shenzhen, Guangdong, 518036 P. R. China. duyp64@public.szptt.net.cn
Ye
Hong-jun
HJ
Long
Xia
X
Yu
Jie
J
Fang
Jia-zhi
JZ
Wang
Jun-ping
JP
Hao
Feng-wen
FW
Jiang
Li
L
Wang
Yuan-yuan
YY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D004381:Duodenal Ulcer / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D055815:Young Adult
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D008562:Membrane Glycoproteins