title: Botanical antioxidants in the prevention of photocarcinogenesis and photoaging.
abstract: Exposure of the skin to ultraviolet (UV) radiation, particularly its UV-B component (280-320 nm), from the sun results in erythema, edema, hyperplasia, hyperpigmentation, sunburn cells, immunosuppression, photoaging, and skin cancer. Amongst these various adverse effects of UV-B radiation, skin cancer and photoaging are of great concern. More recent changes in lifestyle have led to a significant increase in the amount of UV-B radiation people receive leading to a surge in the incidence of skin cancer and photoaging. As these trends are likely to continue in the foreseeable future, the adverse effect of UV-B has become a major human health concern. Therefore, development of novel strategies to reduce the occurrence of skin cancer and delay the process of photoaging are highly desirable goals. One approach to reduce their occurrence is through photochemoprevention, which we define as the use of agents capable of ameliorating the adverse effects of UV-B on the skin. Photochemoprevention via use of botanical antioxidants, present in the common diet of human have gained considerable attention as photochemopreventive agents for human use. Many such agents have also found a place in skin care products. This review will focus on the effects of selected botanical antioxidants in the prevention of photocarcinogenesis and photoaging.
authors.affiliation: Department of Dermatology, University of Wisconsin, Madison, 53706, USA.
authors.forename: Farrukh
authors.initials: F
authors.lastname: Afaq
authors.forename: Hasan
authors.initials: H
authors.lastname: Mukhtar
mesh_terms: D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D019833:Genistein / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D029561:Lythraceae; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D000077185:Resveratrol; D012867:Skin / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000517:prevention & control*; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use; D013662:Tea
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D013267:Stilbenes; D013662:Tea; D019833:Genistein; D000077185:Resveratrol