Intravenous methimazole in the treatment of refractory hyperthyroidism.
BACKGROUND
Management of a hyperthyroid patient unable to take oral or rectal medication is a difficult clinical problem. The need for an alternative parenteral route of antithyroid medication administration in thyrotoxic patients occurs in certain rare cases, such as emergent gastrointestinal surgery, bowel ileus or obstruction, or severe vomiting and diarrhea. We report a simple and successful protocol for the preparation and use of intravenous methimazole (MMI) for treatment of hyperthyroidism in patients intolerant of orally and rectally administered thionamides.


METHODS
Five hundred milligrams of methimazole USP powder was reconstituted with pH-neutral 0.9% sodium chloride solution to a final volume of 50 mL using aseptic technique, then filtered through a 0.22-microm filter. MMI injection was administered as a slow intravenous push over 2 minutes and followed by a saline flush.


METHODS
A 76-year-old man, intolerant of oral and rectal medications because of an ileus and intractable diarrhea, who developed worsening thyrotoxicosis after an emergent spinal cord decompression, and a 42-year-old man with chronic liver disease and hyperthyroidism, requiring emergent exploratory laparotomy and maintenance of complete bowel rest because of persistent gastrointestinal bleeding were rendered euthyroid using intravenous MMI.


CONCLUSIONS
Two cases of hyperthyroidism successfully treated with a preparation of intravenous MMI are described.
Hodak
Steven P
SP
Georgetown University Hospital, Division of Endocrinology and Metabolism, Washington, DC 20007, USA.
Huang
Caroline
C
Clarke
Donna
D
Burman
Kenneth D
KD
Jonklaas
Jacqueline
J
Janicic-Kharic
Natasa
N
D000328:Adult; D000368:Aged; D013956:Antithyroid Agents / Q000008:administration & dosage*; D004333:Drug Administration Routes; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D007262:Infusions, Intravenous; D008297:Male; D008713:Methimazole / Q000008:administration & dosage*; D013961:Thyroid Gland / Q000473:pathology; D013997:Time Factors
D013956:Antithyroid Agents; D008713:Methimazole