A bioactive (1-->3)-, (1--4)-beta-D-glucan from Collybia dryophila and other mushrooms.
Polysaccharides from higher Basidiomycete mushrooms, mainly beta-D-glucans, are considered to be potent bioactive fungal compounds. In this study a beta-glucan (1.237 x 10(6) Da) consisting of (1-->3) and (1-->4) glucosidic linkages, named Collybia dryophila polysaccharide (CDP), was extracted from the wild mushroom C. dryophila. CDP was shown to strongly inhibit nitric oxide production in activated macrophages suggesting that this polysaccharide displays a potential anti-inflammatory activity. In addition it was shown that polysaccharides similar to CDP (CDP-like) are present in Lentinus edodes and different wild mushrooms collected in northeastern North America.
Pacheco-Sanchez
Maribel
M
Centre de recherche en horticulture, Pavilion de l'Envirotron, Université Laval, Quebec QC, G1K 7P4 Canada
Boutin
Yvan
Y
Angers
Paul
P
Gosselin
André
A
Tweddell
Russell J
RJ
D000363:Agaricales / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D048690:Fruiting Bodies, Fungal / Q000378:metabolism; D005936:Glucans / Q000378:metabolism; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D020942:Shiitake Mushrooms / Q000378:metabolism; D047071:beta-Glucans / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D005936:Glucans; D047071:beta-Glucans; D009569:Nitric Oxide; C067858:beta-glucan, (1-3)(1-4)-