title: The relationship between adiponectin levels and metabolic status in centenarian, early elderly, young and obese women.
abstract: OBJECTIVE
  Adipose tissue secretes proteins which regulate energy metabolism and insulin sensitivity. Adiponectin possesses anti-diabetic, anti-atherogenic and insulin-sensitizing properties. To assess the prognostic factors in prolonged survival and the potential protective role of adiponectin in aging, we examined the release of adiponectin in relation to the metabolic status of centenarians, compared with young, early elderly and obese subjects.
  
  
  METHODS
  The study was carried out on 122 women: 22 centenarians aged 100-102 yrs, 45 younger women aged 20-43 yrs, 19 early elderly women aged 64-67 yrs, and 36 obese women aged 26-54 yrs. Anthropometric data, clinical features and blood samples were obtained. Plasma adiponectin and insulin concentrations were measured by RIA methods. Fasting plasma glucose levels, lipid profile and creatinine concentrations were determined using routine laboratory procedures.
  
  
  RESULTS
  In centenarians we found that adiponectin concentrations were significantly increased, compared with young, early elderly and obese women. Insulin concentrations were lower than those in young and obese subjects. HOMA-IR was significantly lower than in obese women. Positive correlations were found between adiponectin and HDL, and negative correlations between adiponectin and HOMA-IR, total cholesterol, LDL, triglycerides, blood pressure and BMI.
  
  
  CONCLUSIONS
  Our results indicate that adiponectin may play a protective role that contributes to longevity.
authors.affiliation: Department of Neuroendocrinology, Medical Centre of Postgraduate Education, Marymoncka 99, 01-813 Warsaw, Poland. zncmkp@op.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Bik
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Baranowska-Bik
authors.forename: Ewa
authors.initials: E
authors.lastname: Wolinska-Witort
authors.forename: Lidia
authors.initials: L
authors.lastname: Martynska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Chmielowska
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Szybinska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Broczek
authors.forename: Boguslawa
authors.initials: B
authors.lastname: Baranowska
mesh_terms: D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001794:Blood Pressure; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008136:Longevity / Q000502:physiology; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides