Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray.
This is a case report of granulocytic sarcoma occurring as a nasal lesion prior to the onset of acute myelogenous leukaemia (AML). To understand this case in more detail, we used 40,000 human cDNA microarray to identify the gene expression patterns of nonleukaemic stage bone marrow (BM), AML stage BM and AML stage peripheral blood cells and subsequently define the molecular basis of this disease progression. Of significance, we have tracked the expression profile of BM samples during the course of nonleukaemic to leukaemic progression, and identified a number of genes that may account for the growth potential of leukaemia cells and indicate poor prognosis of this case.
Teramoto
H
H
Department of Internal Medicine, Kojin Hospital, Nagoya, Japan.
Miwa
H
H
Patel
V
V
Letwin
N
N
Castellone
M D
MD
Imai
N
N
Shikami
M
M
Imamura
A
A
Gutkind
J S
JS
Nitta
M
M
Lee
N H
NH
D000369:Aged, 80 and over; D018450:Disease Progression; D015536:Down-Regulation / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D023981:Sarcoma, Myeloid / Q000235:genetics* / Q000473:pathology; D015854:Up-Regulation / Q000235:genetics