title: [Peculiarities of metabolic characteristics in females of reproductive age with hyperplastic processes of cervix and mammary glands].
abstract: The aim of our investigation was the evaluation of character of metabolic disorders in patients with hyperplastic processes of uterine corpus, cervix and mammary glands. 88 patients of reproductive age with several gynaecological complaints have been investigated. 72 patients with hyperplastic processes of endometrium and endocervix (hyperplasia, polyposis), myoma of uterus, fibroadenoms and adenomatosis of mammary glands were selected in main group. Control group consisted of 16 patients without any hyperplastic processes of genital organs. Metabolic syndrome in main group was revealed in 28% of cases, in control--18.8% (chi(2)=3.95, p=0.047); insulin resistance--30.5% and 18.7% (chi(2)=4.01, p=0.046), respectively. In main group in comparison with control group took place the tendency of the increase triglyceride plasma level and the decrease of levels of HDL-cholesterol. b-cell function was significantly increased in patients with hyperplastic processes of uterine corpus and cervix, in subgroup of uterine myoma revealed the tendency. Insulin resistance revealed in patients with hyperplasia of endocervix and pathologies of mammary glands. Our results suggest that metabolic syndrome and its components significantly influences on the formation of hyperplastic processes of uterine corpus, cervix and mammary glands.
authors.forename: D K
authors.initials: DK
authors.lastname: Virsaladze
authors.forename: B D
authors.initials: BD
authors.lastname: Tkeshelashvili
authors.forename: L V
authors.initials: LV
authors.lastname: Dzhavashvili
authors.forename: N R
authors.initials: NR
authors.lastname: Kadzhaia
authors.forename: M P
authors.initials: MP
authors.lastname: Khutsishvili
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000378:metabolism* / Q000473:pathology*; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D007333:Insulin Resistance; D042361:Mammary Glands, Human / Q000378:metabolism* / Q000473:pathology*; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism*; D011379:Prognosis; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides