title: Numerical predictions of the thermal behaviour and resultant effects of grouting cements while setting prosthetic components in bone.
abstract: Acrylic cements are commonly used to attach prosthetic components in joint replacement surgery. The cements set in short periods of time by a complex polymerization of initially liquid monomer compounds into solid structures with accompanying significant heat release. Two main problems arise from this form of fixation: the first is the potential damage caused by the temperature excursion, and the second is incomplete reaction leaving active monomer compounds, which can potentially be slowly released into the patient. This paper presents a numerical model predicting the temperature-time history in an idealized prosthetic-cement-bone system. Using polymerization kinetics equations from the literature, the degree of polymerization is predicted, which is found to be very dependent on the thermal history of the setting process. Using medical literature, predictions for the degree of thermal bone necrosis are also made. The model is used to identify the critical parameters controlling thermal and unreacted monomer distributions.
authors.affiliation: Department of Mechanical Engineering, University of Bristol, UK. joe.quarini@bristol.ac.uk
authors.forename: G L
authors.initials: GL
authors.lastname: Quarini
authors.forename: I D
authors.initials: ID
authors.lastname: Learmonth
authors.forename: S
authors.initials: S
authors.lastname: Gheduzzi
mesh_terms: D001843:Bone Cements / Q000009:adverse effects* / Q000737:chemistry*; D003198:Computer Simulation; D006244:Hardness; D006801:Humans; D007595:Joint Prosthesis / Q000009:adverse effects*; D008422:Materials Testing; D008954:Models, Biological; D010020:Osteonecrosis / Q000209:etiology / Q000503:physiopathology*; D019919:Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods*; D013696:Temperature
chemical_list: D001843:Bone Cements