title: A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease.
abstract: We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P=.007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.
authors.affiliation: Wellcome Trust Centre for Human Genetics, Churchill Hospital, University of Oxford, Oxford, United Kingdom, OX3 7BN. grahamc@well.ox.ac.uk
authors.forename: Graham S
authors.initials: GS
authors.lastname: Cooke
authors.forename: Kerrie
authors.initials: K
authors.lastname: Tosh
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Ramaley
authors.forename: Pontiano
authors.initials: P
authors.lastname: Kaleebu
authors.forename: Joanna
authors.initials: J
authors.lastname: Zhuang
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Nakiyingi
authors.forename: Christine
authors.initials: C
authors.lastname: Watera
authors.forename: Charles F
authors.initials: CF
authors.lastname: Gilks
authors.forename: Neil
authors.initials: N
authors.lastname: French
authors.forename: James A G
authors.initials: JA
authors.lastname: Whitworth
authors.forename: Adrian V S
authors.initials: AV
authors.lastname: Hill
mesh_terms: D018946:Chemokine CCL5 / Q000235:genetics*; D015331:Cohort Studies; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000235:genetics* / Q000401:mortality* / Q000503:physiopathology; D006720:Homozygote; D006801:Humans; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D016019:Survival Analysis; D016896:Treatment Outcome; D014454:Uganda
chemical_list: D018946:Chemokine CCL5