Synthesis and neuroprotective effects of serofendic acid analogues.
Analogues of serofendic acid were prepared and their protective effects against L-glutamate (Glu)-induced neurotoxicity were examined using primary cultures of rat cortical neurons. Some analogues exhibited similar neuroprotective activity to that of serofendic acid.
Terauchi
Taro
T
Tsukuba Research Laboratories, Eisai Co. Ltd, Tsukuba-Shi 300-2635, Japan. t-terauchi@hhc.eisai.co.jp
Doko
Takashi
T
Yonaga
Masahiro
M
Kajiwara
Akiharu
A
Niidome
Tetsuhiro
T
Taguchi
Ryota
R
Kume
Toshiaki
T
Akaike
Akinori
A
Sugimoto
Hachiro
H
D000818:Animals; D002478:Cells, Cultured; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D018698:Glutamic Acid / Q000009:adverse effects; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000138:chemical synthesis*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D013329:Structure-Activity Relationship
D004224:Diterpenes; D018696:Neuroprotective Agents; C452642:serofendic acid; D018698:Glutamic Acid