How inflammation changes neuromuscular function and its relevance to symptoms in diverticular disease.
Diverticulosis is largely asymptomatic but recent evidence suggests that episodes of acute diverticulitis double the risk of subsequently suffering from recurrent noninflammatory pain. Numerous animal models demonstrate how inflammation is followed by circular muscle hypertrophy, abnormalities of innervation, and increased sensitivity to cholinergic agents. There is also an impairment of norepinephrine and acetylcholine release and damage to nitrergic neurons. These changes are also associated with visceral hypersensitivity. Many of the features, including visceral hypersensitivity are also seen in symptomatic patients with diverticulosis. The trinitrobenzene sulfonic acid colitis model demonstrates that inflammation is followed by long lasting increases in tachykinin and other neuropeptide immunoreactivity. These changes occur both in the mucosa and myenteric plexus and parallel changes seen in resections and mucosal biopsies in diverticular patients. These neural abnormalities may be responsible for the visceral hypersensitivity, which explains why symptoms correlate poorly with objective abnormalities such as intraluminal pressure or motor patterns. Treatment of visceral hypersensitivity might be more effective than current therapies that often leave pain unaltered.
Spiller
Robin
R
Wolfson Digestive Diseases Centre, University of Nottingham, University Hospital, Nottingham, UK.
D000818:Animals; D004195:Disease Models, Animal; D004239:Diverticulitis, Colonic / Q000150:complications / Q000276:immunology* / Q000503:physiopathology*; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007249:Inflammation; D051379:Mice; D009130:Muscle, Smooth / Q000294:innervation* / Q000473:pathology / Q000503:physiopathology*; D009197:Myenteric Plexus / Q000473:pathology / Q000503:physiopathology*; D009473:Neuronal Plasticity / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D010146:Pain / Q000209:etiology / Q000503:physiopathology
D018377:Neurotransmitter Agents