title: In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: A physicochemical and cyto-genotoxical study.
abstract: Although the current production of oxide nanoparticles may be modest, the wide range of proposed applications and forecasted growth in production has raised questions about the potential impact of these nanoparticles on the environment and human health. Iron oxide nanoparticles have been proposed for an increasing number of biomedical applications although in vitro toxicity depending on the particles coating has been evidenced. The aim of this study was to examine the potential in vitro cyto- and genotoxicity on human dermal fibroblasts of DMSA-coated maghemite nanoparticles (NmDMSA) as a function of well-defined physicochemical states. Well-stabilized NmDMSA produced weak cytotoxic and no genotoxic effects. This is attributed in part to the DMSA coating, which serves as a barrier for a direct contact between nano-oxide and fibroblasts, inhibiting a potential toxic effect.
authors.affiliation: CEREGE UMR 6635 CNRS-Université Paul Cézanne, Europôle de l'Arbois 13545 Aix-en-Provence, France. auffan@cerege.fr
authors.forename: Melanie
authors.initials: M
authors.lastname: Auffan
authors.forename: Laetitia
authors.initials: L
authors.lastname: Decome
authors.forename: Jerome
authors.initials: J
authors.lastname: Rose
authors.forename: Thierry
authors.initials: T
authors.lastname: Orsiere
authors.forename: Michel
authors.initials: M
authors.lastname: De Meo
authors.forename: Valerie
authors.initials: V
authors.lastname: Briois
authors.forename: Corinne
authors.initials: C
authors.lastname: Chaneac
authors.forename: Luca
authors.initials: L
authors.lastname: Olivi
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Berge-Lefranc
authors.forename: Alain
authors.initials: A
authors.lastname: Botta
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wiesner
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Bottero
mesh_terms: D005347:Fibroblasts / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D046529:Microscopy, Electron, Transmission; D009153:Mutagens / Q000633:toxicity*; D053758:Nanoparticles; D013057:Spectrum Analysis; D004113:Succimer / Q000633:toxicity*; D014965:X-Rays
chemical_list: D009153:Mutagens; D004113:Succimer