title: The IL-10 -1082G polymorphism is associated with clearance of HPV infection.
abstract: The role of cytokines in protecting against human papillomavirus (HPV) and HPV-associated disease is not fully understood. We compared the frequency of the interleukin (IL)-10 polymorphism (G allele) at position --1082 and the distribution of GG/GA/AA genotypes among 116 HPV-positive women, grouped according to their cervical cytological profiles, with 119 HPV-negative controls with normal smears. No difference was observed in genotype frequency between the groups. Among women in the HPV-positive, smear-normal group, who were re-tested for HPV after 12 months, there was a significant inverse association between presence of at least one variant G allele (high activity) and HPV persistence (OR per G allele = 0.082 [95% CI 0.009-0.73], P= 0.001; after controlling for ethnicity). This association remained significant after controlling for age, smoking and hormonal contraception (OR = 0.028 [95% CI 0.001-0.66], P= 0.001). This preliminary study suggests that higher levels of IL-10 may prevent cervical neoplasia through their role in eliminating HPV.
authors.affiliation: Academic Unit of Obstetrics & Gynaecology, St Mary's Hospital, Manchester, UK.
authors.forename: F
authors.initials: F
authors.lastname: Farzaneh
authors.forename: Sa
authors.initials: S
authors.lastname: Roberts
authors.forename: D
authors.initials: D
authors.lastname: Mandal
authors.forename: B
authors.initials: B
authors.lastname: Ollier
authors.forename: U
authors.initials: U
authors.lastname: Winters
authors.forename: H C
authors.initials: HC
authors.lastname: Kitchener
authors.forename: L
authors.initials: L
authors.lastname: Brabin
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D030361:Papillomavirus Infections / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D016753:Interleukin-10