title: [Morphological peculiarities of consolidation of experimental mandible fractures by osteosynthesis using Kollapan and retabolil].
abstract: The Purpose of the research was to study in the experiment morphological particularities of mandible fracture consolidation by osteosynthesis using Kollapan and Retabolil. The experiments were carried out on sexually matured rabbits. In the first series of the experiments (the control group), mandibula bones fracture was prototyped lower, whereas bone fragments were fixed by miniplate. In the second series of the experiments (the study group) bone fragments were bolted by the above mentioned way but diastase between bone fragments was filled by Kollapan granules, containing klaforan, and animals were intramuscularly anabolic material (the retabolil 0.4 mg/kg). On the 3-d and 15-th days, as well as, after 1 and 2 months after operation observing all corresponding rules, animals were killed and patologico-anatomic study of jaw bone was carried out. The analysis of the results showed that in experimental animals both in the control and the study groups reparative regeneration of bone tissues runs with the formation of periosteum and intermedium regenerator, at the same time consolidation of the bone defect in the main group occurs earlier than in the control group. The Results of the studies point out that Retabolil under osteosynthesis is an osteoinductive material and Kollapan, having osteoinductive, osteoconductive, and osteoprotective characteristics, promotes speeding of the process of jaw bones fracture consolidation.
authors.forename: G K
authors.initials: GK
authors.lastname: Beriashvili
authors.forename: G T
authors.initials: GT
authors.lastname: Menabde
authors.forename: R T
authors.initials: RT
authors.lastname: Chikhladze
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology*; D004195:Disease Models, Animal; D004338:Drug Combinations; D017886:Durapatite / Q000494:pharmacology*; D005592:Fracture Fixation / Q000379:methods*; D008297:Male; D008337:Mandibular Fractures / Q000473:pathology / Q000628:therapy*; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D011817:Rabbits; D016896:Treatment Outcome
chemical_list: D045930:Anabolic Agents; D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D009277:Nandrolone; D003094:Collagen; D017886:Durapatite; D000077603:Nandrolone Decanoate