title: Serum leptin is not a diagnostic marker for familial Mediterranean fever attacks.
abstract: The aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of 24.42 +/- 1.22 (Mean +/- SEM) years and 24.30 +/- 1.19 years (Mean +/- SEM), respectively. We investigated serum levels of leptin, interleukin-6 (IL-6) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP),fibrinogen, and leukocyte counts before the attack and 8-12 hours after the attack started. The same parameters have been investigated in the control subjects. The mean serum leptin levels before the attacks were 6.45 +/- 1.05 (Mean +/- SEM) and during the attacks were 7.59 +/- 1.3 (Mean +/- SEM) in FMF group,respectively. There was a slight increase in serum leptin levels during the attacks but it was not statistically significant (P > .05). The mean serum leptin levels were 16.12 +/- 2.81 in the control group which were not different from the mean serum leptin levels before and during the attack periods in the study group (P > .05). However, there were statistical differences in the serum levels of IL-6, ESR, CRP, fibrinogen, and leukocyte counts before and during the attack periods (P > .05). No correlation was found between serum leptin levels and IL-6, ESR, CRP, fibrinogen, and leukocyte counts (P > .05). Serum leptin levels do not increase during FMF attacks and therefore it is not useful for diagnostic purposes and follow-up during treatment.
authors.affiliation: Department of Gastroenterology, Gülhane Military Medical Academy, Ankara 06018, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Toy
authors.forename: Orhan
authors.initials: O
authors.lastname: Tarçin
authors.forename: Sait
authors.initials: S
authors.lastname: Bağci
authors.forename: Yücel
authors.initials: Y
authors.lastname: Ustündağ
authors.forename: Ali
authors.initials: A
authors.lastname: Inal
authors.forename: Arzu
authors.initials: A
authors.lastname: Tiftikçi
mesh_terms: D000328:Adult; D015415:Biomarkers; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000096:biosynthesis; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005340:Fibrinogen / Q000096:biosynthesis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood*; D007958:Leukocyte Count; D008297:Male
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D020738:Leptin; D005340:Fibrinogen; D002097:C-Reactive Protein