title: New antimicrobials, systemic distribution, and local methods of antimicrobial delivery in horses.
abstract: The local delivery of antimicrobials is a valuable therapeutic tool with a low morbidity, is practical to use, and is well tolerated by horses. Clinically, its use has allowed equine practitioners to achieve better results when treating musculoskeletal infections, and it represents an extremely useful tool in the practitioner's armamentarium against these types of infections. The technique is indicated to combat orthopedic infections involving bones, joints, physes, tendon sheaths, and foot tissues. Optimal treatment must include other approaches, such as systemic antimicrobial therapy and surgical debridement and lavage, and monitoring of the clinical progression of the patient can help to determine the ideal protocol for each patient.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1. acruz@uoguelph.ca
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Cruz
authors.forename: Luis
authors.initials: L
authors.lastname: Rubio-Martinez
authors.forename: Trisha
authors.initials: T
authors.lastname: Dowling
mesh_terms: D020341:Absorbable Implants / Q000662:veterinary; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000662:veterinary*; D004343:Drug Implants / Q000008:administration & dosage; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007260:Infusion Pumps / Q000662:veterinary; D007270:Injections, Intra-Articular / Q000662:veterinary; D010477:Perfusion / Q000662:veterinary
chemical_list: D000890:Anti-Infective Agents; D004343:Drug Implants