title: Bone morphogenetic proteins in orthopaedic trauma: recent clinical findings with human bone morphogenetic protein-2 (rhBMP-2).
abstract: This article introduces papers based on presentations from a symposium entitled "Bone Morphogenic Protein Advisory Meeting in Orthopaedic Trauma", where recent clinical findings with human bone morphogenetic protein-2 (rhBMP-2) were reviewed. It also presents two case studies which illustrate the clinical problems with the potential morbidity of tibial fractures and the potential benefits of the use of rhBMP-2 at surgery. The article concludes with a summary of the symposium. Tibial shaft fracture repair is associated with a significant financial burden on the patient, the health care providers and the medical insurance companies. It is anticipated that the clinical advantages of rhBMP-2 could lead to cost savings both inside and outside the hospital setting.
authors.affiliation: Norfolk and Norwich University Hospital NHS Trust, Colney Lane, Norwich NR4 7UY, UK. ad.patel@nnuh.nhs.uk
authors.forename: A D
authors.initials: AD
authors.lastname: Patel
mesh_terms: D000328:Adult; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000191:economics; D003362:Cost-Benefit Analysis; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D008297:Male; D019637:Orthopedic Procedures; D011859:Radiography; D011994:Recombinant Proteins / Q000627:therapeutic use*; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery
chemical_list: D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2