title: Validation of a noninvasive neonatal optical cerebral oximeter in veno-venous ECMO patients with a cephalad catheter.
abstract: BACKGROUND
  Cerebral Oximetry is an optical technique that allows for noninvasive and continuous monitoring of brain oxygenation by determining tissue oxygen saturation (SctO2). In conjunction with pulse oximetry, cerebral oximetry offers a promising method to estimate cerebral venous oxygen saturation (SvO2).
  
  
  OBJECTIVE
  The aim of this study was to validate the cerebral oximetry measurements with the cerebral oxygen saturation measured from blood drawn in neonates on veno-venous ECMO with existing cephalad catheter with a prototype neonatal cerebral oximeter developed by CAS Medical Systems (Branford, CT, USA).
  
  
  METHODS
  After obtaining informed consent, neonates undergoing VV-ECMO with cephalad catheterization were monitored by the CAS cerebral oximeter. Cephalad blood samples were periodically obtained to validate the monitor's accuracy.
  
  
  RESULTS
  Seventeen neonates were studied with 1718 h of cerebral oximetry data collected. Compared to the reference values, the bias+/-precision for cerebral oximetry SctO2 was 0.4+/-5.1% and derived SvO2 was 0.6+/-7.3%.
  
  
  CONCLUSIONS
  We recommend the use of this noninvasive method as an alternative to blood draws for cerebral venous saturation measurements in neonates requiring extracorporeal life support.
authors.affiliation: Department of Neonatology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA. kraisbah@cnmc.org
authors.forename: K
authors.initials: K
authors.lastname: Rais-Bahrami
authors.forename: O
authors.initials: O
authors.lastname: Rivera
authors.forename: B L
authors.initials: BL
authors.lastname: Short
mesh_terms: D001923:Brain Chemistry / Q000502:physiology; D002408:Catheters, Indwelling; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood; D012044:Regression Analysis; D019265:Spectroscopy, Near-Infrared
chemical_list: D010100:Oxygen