Gout: new insights into an old disease.
Gout is an autoinflammatory disorder associated with deposition of monosodium urate (MSU) crystals in joints and periarticular tissues. Recent advances suggest that the innate immune system may drive the gouty inflammatory response to MSU. These findings prompt questions concerning how the innate immune system recognizes MSU and the identities of the receptors involved. In this issue of the JCI, Chen et al. show that the IL-1 receptor and its signaling protein myeloid differentiation primary response protein 88 (MyD88) but not the "classical" innate immune receptors, TLRs, are central for MSU-induced inflammation (see the related article beginning on page 2262).
Martinon
Fabio
F
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Glimcher
Laurie H
LH
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D006073:Gout / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D008954:Models, Biological; D053594:Myeloid Differentiation Factor 88
D048868:Adaptor Proteins, Signal Transducing; C507779:MYD88 protein, human; D053594:Myeloid Differentiation Factor 88