title: CD19/22 balance relates to improvement of disease activity in systemic lupus erythematosus.
abstract: B cells in patients with systemic lupus erythematosus (SLE) are hyperactivated and B-cell receptor signal transduction may be affected by various response regulators. CD19 and CD22 play a major role as regulators of B-cell response. Therefore, we examined CD19 and CD22 expressions on B cells of patients with SLE, and how they were related to disease activity. Thirty-one patients with active SLE were selected and enrolled in this study. Evaluation of CD19 and CD22 expressions on B cells was performed prior to and after treatments with flow cytometry analysis. Disease activity was determined according to the SLE disease activity index score. CD19 and CD22 expressions on B cells in SLE patients revealed no significant differences when compared with the controls. However, improvement of SLE was recognized among patients with an increased ratio of CD22-positive cells. Our results suggest that this balance is a useful marker for determining improvement of SLE disease activity, although the CD19/22 balance does not contribute to the pathogenesis of SLE.
authors.affiliation: Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. jade.s@nifty.ne.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Suzuki
authors.forename: Souichiro
authors.initials: S
authors.lastname: Nakano
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakairi
authors.forename: Akiko
authors.initials: A
authors.lastname: Mitsuo
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Amano
authors.forename: Shinji
authors.initials: S
authors.lastname: Morimoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tokano
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Takasaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018941:Antigens, CD19 / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000378:metabolism*
chemical_list: D018941:Antigens, CD19; D015415:Biomarkers; C497867:CD22 protein, human; D051918:Sialic Acid Binding Ig-like Lectin 2