title: Sodium iron (III) ethylenediaminetetraacetic acid synthesis to reduce iron deficiency globally.
abstract: Despite major interest in sodium iron (III) ethylenediaminetetraacetic acid's (EDTA) potential use in food fortification programs in potentially curbing the global problem of iron deficiency and its anemia, synthesis methods of stable isotope-labeled sodium iron (III) EDTA for use in human bioavailability studies are incomplete, incorrect or totally lacking. Owing to a number of clinical research groups requiring this compound in bioavailability studies, in both developing and already developed countries, we simplified and optimized the synthesis of sodium iron (III) EDTA from a block of isotopically enriched iron metal, in order that it be easily reproduced, cheaply, using simple basic laboratory apparatus. The resulting product is of high purity (>99.0%), and may be used for human stable isotope bioavailability studies. The simplicity of this method allows for the many research groups, currently doing such studies, to perform their own syntheses. Additionally, more uniformity in this synthesis will reduce the variation observed between such studies.
authors.affiliation: Department of Nutrition, School of Physiology, Nutrition and Consumer Sciences, North-West University, Potchefstroom, South Africa. vgedtl@puk.ac.za
authors.forename: Du T
authors.initials: du T
authors.lastname: Loots
authors.forename: M
authors.initials: M
authors.lastname: van Lieshout
authors.forename: M V
authors.initials: MV
authors.lastname: Lieshout
authors.forename: G
authors.initials: G
authors.lastname: Lachmann
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D001682:Biological Availability; D004492:Edetic Acid / Q000493:pharmacokinetics / Q000627:therapeutic use; D005290:Ferric Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005527:Food, Fortified; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007503:Iron Isotopes
chemical_list: D005290:Ferric Compounds; D007503:Iron Isotopes; D004492:Edetic Acid; D007501:Iron; C019179:Fe(III)-EDTA