title: A novel antiproliferative agent, phenylpyridineylbutenol, isolated from Streptomyces sp.
abstract: A novel compound showing antiproliferative effect was isolated from Streptomyces sp. Its structure was determined based on the interpretation of the NMR spectra, and its conformation was elucidated using molecular modeling and 2D NOESY. It was determined to be (E)-4-phenyl-3-(pyridine-2-yl)but-2-en-1-ol.
authors.affiliation: Bio/Molecular Informatics Center, Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Choonshik
authors.initials: C
authors.lastname: Shin
authors.forename: Haeyoung
authors.initials: H
authors.lastname: Lim
authors.forename: Sangik
authors.initials: S
authors.lastname: Moon
authors.forename: Seunghyun
authors.initials: S
authors.lastname: Kim
authors.forename: Yeonjoong
authors.initials: Y
authors.lastname: Yong
authors.forename: Bum-Joon
authors.initials: BJ
authors.lastname: Kim
authors.forename: Chul-Hoon
authors.initials: CH
authors.lastname: Lee
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000440:Butanols / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013302:Streptomyces
chemical_list: D000970:Antineoplastic Agents; D000440:Butanols; D011725:Pyridines