title: Designing research studies on psychosocial interventions in autism.
abstract: To address methodological challenges in research on psychosocial interventions for autism spectrum disorder (ASD), a model was developed for systematically validating and disseminating interventions in a sequence of steps. First, initial efficacy studies are conducted to establish interventions as promising. Next, promising interventions are assembled into a manual, which undergoes pilot-testing. Then, randomized clinical trials test efficacy under controlled conditions. Finally, effectiveness studies evaluate outcomes in community settings. Guidelines for research designs at each step are presented. Based on the model, current priorities in ASD research include (a) preparation for efficacy and effectiveness trials by developing manuals for interventions that have shown promise and (b) initial efficacy studies on interventions for core features of ASD such as social reciprocity.
authors.affiliation: Department of Pediatrics, Strong Center for Developmental Disabilities, University of Rochester Medical Center, 601 Elmwood, Box 671, Rochester, NY 14642, USA. Tristram_Smith@URMC.Rochester.edu
authors.forename: Tristram
authors.initials: T
authors.lastname: Smith
authors.forename: Lawrence
authors.initials: L
authors.lastname: Scahill
authors.forename: Geraldine
authors.initials: G
authors.lastname: Dawson
authors.forename: Donald
authors.initials: D
authors.lastname: Guthrie
authors.forename: Catherine
authors.initials: C
authors.lastname: Lord
authors.forename: Samuel
authors.initials: S
authors.lastname: Odom
authors.forename: Sally
authors.initials: S
authors.lastname: Rogers
authors.forename: Ann
authors.initials: A
authors.lastname: Wagner
mesh_terms: D001321:Autistic Disorder / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D011613:Psychotherapy / Q000379:methods*; D012107:Research Design