title: Tacrolimus treatment for refractory lupus cystitis.
abstract: A 23-year-old woman presented with recurrence of lupus cystitis, which had been in remission under daily administration of a single corticosteroid over a period of 8 years. She was treated with increased doses of corticosteroid and immunosuppressants, i.e., cyclosporin, cyclophosphamide, azathioprine, and salazosulfapyridine, but the cystitis remained active. Since her condition became critical by the complication of intestinal pseudo-obstruction, tacrolimus was administered. This agent induced a remission promptly without significant adverse events in this patient, suggesting an efficacy to lupus cystitis refractory to corticosteroid and other immunosuppressants.
authors.affiliation: Department of Medicine, Division of Respiratology and Neurology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan. maruoka@med.kurume-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maruoka
authors.forename: Seiyo
authors.initials: S
authors.lastname: Honda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takeo
authors.forename: Takeharu
authors.initials: T
authors.lastname: Koga
authors.forename: Takaaki
authors.initials: T
authors.lastname: Fukuda
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Aizawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D003556:Cystitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging / Q000209:etiology; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007418:Intestinal Pseudo-Obstruction / Q000000981:diagnostic imaging / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D011859:Radiography; D016559:Tacrolimus / Q000008:administration & dosage*; D014463:Ultrasonography
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016559:Tacrolimus