title: A randomized clinical multicentre trial comparing enamel matrix derivative and membrane treatment of buccal class II furcation involvement in mandibular molars. Part III: patient factors and treatment outcome.
abstract: OBJECTIVE
  Evaluation of effects of patient factors on the outcome of regenerative treatment of buccal mandibular class II furcation defects.
  
  
  METHODS
  Fifty-one patients were recruited. In the intention-to-treat population 21 patients were allocated into the sequence left treatment with enamel matrix protein derivative (EMD) and right guided tissue regeneration (GTR) and 27 in the sequence left GTR and right EMD. Evaluated patient factors were: smoking, age, gender, hypertension and oral hygiene status. Outcome parameters included change of: (a) horizontal depth of the defect at the deepest point (b) distance from the fornix of the furcation to bone crest of the defect, (c) distance from stent to the bottom of the defect, (d) pocket depth and (e) attachment level at the middle of the furcation.
  
  
  RESULTS
  In patients 54 years of age and older, in males, in non-smokers and in patients with "poor" hygiene EMD-treated sites showed a significant higher mean reduction of the parameters d (age), b (gender, hygiene) a (smoking, hygiene) when compared with sites treated with GTR.
  
  
  CONCLUSIONS
  These data provided an indication of a possible effect of patient factors on the outcome of regenerative treatment of buccal mandibular class II furcation defects.
authors.affiliation: Department of Conservative Dentistry, University of Technology, Dresden, Germany. th.hoffm@rcs.urz.tu-dresden.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoffmann
authors.forename: Steffen
authors.initials: S
authors.lastname: Richter
authors.forename: Joerg
authors.initials: J
authors.lastname: Meyle
authors.forename: Jose R
authors.initials: JR
authors.lastname: Gonzales
authors.forename: Bernd
authors.initials: B
authors.lastname: Heinz
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Arjomand
authors.forename: Anton
authors.initials: A
authors.lastname: Sculean
authors.forename: Elmar
authors.initials: E
authors.lastname: Reich
authors.forename: Karin
authors.initials: K
authors.lastname: Jepsen
authors.forename: Søren
authors.initials: S
authors.lastname: Jepsen
authors.forename: Rolf-Hasso
authors.initials: RH
authors.lastname: Boedeker
mesh_terms: D000367:Age Factors; D000539:Alveolar Process / Q000473:pathology; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000502:physiology; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D017823:Furcation Defects / Q000145:classification / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008334:Mandible; D008567:Membranes, Artificial; D008875:Middle Aged; D008963:Molar / Q000601:surgery*; D009910:Oral Hygiene; D017622:Periodontal Attachment Loss / Q000145:classification; D010514:Periodontal Pocket / Q000145:classification; D011098:Polyglactin 910 / Q000627:therapeutic use; D012737:Sex Factors; D012907:Smoking / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D003746:Dental Enamel Proteins; D008567:Membranes, Artificial; C094810:Resolut; C109069:enamel matrix proteins; D011098:Polyglactin 910