Cytotoxic activities of chemical constituents from Mesua daphnifolia.
Detail chemical investigations on the stem bark of Mesua daphnifolia gave three triterpenoids and four xanthones. They are friedelin (1), friedelan-1,3-dione (2), lup-20(29)- en-3ss-ol (3), cudraxanthone G (4), ananixanthone (5), 1,3,5-trihydroxy-4-methoxyxanthone (6) and euxanthone (7). These chemical constituents were tested in vitro for their cytotoxic activities against four cell lines, MDA-MB-231 (human estrogen receptor negative breast cancer), HeLa (cervical carcinoma), CEM-SS (T-lymphoblastic leukemia) and CaOV3 (human ovarian cancer). Compound 4 showed a broad spectrum of activity against the MDA-MB-231, HeLa and CEM-SS cell lines with IC5 0 values of 1.3, 4.0 and 6.7 microg/ml respectively. Meanwhile, the other compounds 1, 2, 3, 5, 6 and 7 gave only selective activities against the cell lines.
Ee
G C L
GC
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Lim
C K
CK
Rahmat
A
A
Lee
H L
HL
D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D045744:Cell Line, Tumor / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry* / Q000145:classification; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008296:Malaysia; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000633:toxicity*; D044004:Xanthones / Q000737:chemistry / Q000633:toxicity*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D013729:Terpenes; D044004:Xanthones; C404221:euxanthone