title: Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey.
abstract: BACKGROUND
  Invasive aspergillosis is an opportunistic infection that occurs mainly among patients with prolonged neutropenia. Few data are available on invasive aspergillosis in nonneutropenic patients.
  
  
  METHODS
  The aim of this survey was to compare neutropenic and nonneutropenic patients who had received a diagnosis of invasive aspergillosis at our institution during a 6-year period.
  
  
  RESULTS
  Among the 88 cases of invasive aspergillosis analyzed here, 12 were histologically proven, 52 were probable, and 24 were possible. Forty-seven percent of cases were diagnosed in the intensive care unit, and 40% were diagnosed in hematology units. Neutropenia was a risk factor for 52 patients (59%), most of whom had hematological or solid malignancies. Among the 36 nonneutropenic patients (41%), the main underlying conditions were steroid-treated chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, giant-cell arteritis, and microvascular disorders; 10 patients were recipients of solid-organ transplants, and 1 patient was seropositive for human immunodeficiency virus. The distribution of proven and probable invasive aspergillosis was similar for neutropenic and nonneutropenic patients. The mortality rate was 71.5% overall and was significantly higher among nonneutropenic patients than among neutropenic patients (89% vs. 60%; P<.05). Compared with neutropenic patients, nonneutropenic patients were significantly less likely to have symptoms of invasive aspergillosis and more likely to have frequent intercurrent pneumonia due to another microorganism. The sensitivity of mycological examination of bronchoalveolar lavage fluid specimens was higher for nonneutropenic patients than for neutropenic patients (85% vs. 58%; P<.05), whereas the sensitivity of antigenemia was the same for the 2 populations (65% vs. 64%). Findings on thoracic computed tomographs were similar, except that segmental areas of consolidation occurred more frequently among neutropenic patients.
  
  
  CONCLUSIONS
  This survey at a whole institution underlines the high number of cases of invasive aspergillosis among nonneutropenic patients, with an overall mortality rate that was significantly higher than that for neutropenic patients.
authors.affiliation: Laboratoire de Parasitologie-Mycologie,Hôpital Pontchaillou, Rennes, France.
authors.forename: A
authors.initials: A
authors.lastname: Cornillet
authors.forename: C
authors.initials: C
authors.lastname: Camus
authors.forename: S
authors.initials: S
authors.lastname: Nimubona
authors.forename: V
authors.initials: V
authors.lastname: Gandemer
authors.forename: P
authors.initials: P
authors.lastname: Tattevin
authors.forename: C
authors.initials: C
authors.lastname: Belleguic
authors.forename: S
authors.initials: S
authors.lastname: Chevrier
authors.forename: C
authors.initials: C
authors.lastname: Meunier
authors.forename: C
authors.initials: C
authors.lastname: Lebert
authors.forename: M
authors.initials: M
authors.lastname: Aupée
authors.forename: S
authors.initials: S
authors.lastname: Caulet-Maugendre
authors.forename: M
authors.initials: M
authors.lastname: Faucheux
authors.forename: B
authors.initials: B
authors.lastname: Lelong
authors.forename: E
authors.initials: E
authors.lastname: Leray
authors.forename: C
authors.initials: C
authors.lastname: Guiguen
authors.forename: J-P
authors.initials: JP
authors.lastname: Gangneux
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000908:Antibodies, Fungal / Q000097:blood; D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000097:blood; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000908:Antibodies, Fungal; D000935:Antifungal Agents; D000946:Antigens, Fungal