title: Spontaneous regression of metastases including meningeal metastasis after gross resection of primary tumor in an infant with stage 4 neuroblastoma.
abstract: Neuroblastoma is the most common extracranial solid tumor in childhood. Spontaneous regression has been well described in infants, especially in those with stage 4S and those with low-stage neuroblastoma detected by screening. However, neuroblastoma presenting with intracranial metastasis is generally considered to need a postoperative chemotherapy. Here, we report a 3-month-old girl with stage 4 neuroblastoma presenting with spontaneous regression of metastatic tumor including meningeal metastasis after gross resection of primary tumor. Further investigation may be required to detect patients of this kind without the need of postoperative chemotherapy regardless of their stage at diagnosis.
authors.affiliation: Department of Hematology/Oncology, Shizuoka Children's Hospital, Shizuoka, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishio
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Mimaya
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Horikoshi
authors.forename: Naoki
authors.initials: N
authors.lastname: Okada
authors.forename: Taemi
authors.initials: T
authors.lastname: Nara
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Takashima
authors.forename: Naoto
authors.initials: N
authors.lastname: Urushihara
authors.forename: Shiro
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Aoki
authors.forename: Minoru
authors.initials: M
authors.lastname: Hamasaki
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D009365:Neoplasm Regression, Spontaneous; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods