Cytokinesis goes polo.
Temporal and spatial coordination of cytokinesis with chromosome segregation is key for successful cell division, but it is poorly understood. A recent article in Science by Pellman and coworkers (Yoshida et. al., 2006) reveals how the yeast polo-like kinase Cdc5 triggers Rho1/RhoA activation and the assembly of the contractile actin ring during anaphase.
Rauter
Harald
H
Institute of Biochemistry, Eidgenössische Technische Hochschule Zurich, 8093 Zurich, Switzerland.
Barral
Yves
Y
D000199:Actins / Q000378:metabolism; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D020090:Chromosome Segregation / Q000502:physiology; D048749:Cytokinesis; D008938:Mitosis / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D000199:Actins; D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C081927:CDC5 protein, S cerevisiae; C051302:RHO1 protein, S cerevisiae; D020741:rho GTP-Binding Proteins