Dirty dealing: hepatic vagal afferents reshuffle fat distribution.
To evaluate the role of hepatic peroxisome-proliferator-activated receptor (PPAR) gamma 2 in the control of energy balance, Uno and colleagues examined the metabolic effects of overexpression of PPAR gamma 2 selectively in mouse and rat liver. Mice demonstrated a surprising degree of hepatic steatosis accompanied by significant reductions in peripheral adiposity. This crosstalk between liver and adipose tissue appears to be mediated by both the sensory component of the hepatic vagus nerve and sympathetic efferents. These data suggest a novel hepatic-adipose neuraxis that regulates the distribution of stored fat.
Schwartz
Gary J
GJ
Albert Einstein College of Medicine of Yeshiva University, Diabetes Research and Training Center, Department of Medicine, 1300 Morris Park Avenue, Golding 501, Bronx, New York 10463, USA.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D008099:Liver / Q000294:innervation* / Q000378:metabolism; D051379:Mice; D047495:PPAR gamma / Q000378:metabolism*; D051381:Rats; D014630:Vagus Nerve
D047495:PPAR gamma