Canonical Wnt signaling: an unexpected new player.
Canonical Wnt signaling, below the Fz/LRP receptor complex, induces the stabilization of beta-catenin via an unresolved mechanism. A recent study in Genes & Development introduces a new player and deepens our understanding of this signaling relay that plays pivotal roles during embryogenesis and tumorigenesis.
Habas
Raymond
R
Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School and The Cancer Institute of New Jersey, Piscataway, New Jersey 08854, USA.
D000818:Animals; D051157:Frizzled Receptors / Q000378:metabolism; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000378:metabolism; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism
D051157:Frizzled Receptors; D026502:LDL-Receptor Related Proteins; D008840:Microfilament Proteins; D051153:Wnt Proteins; D051176:beta Catenin