title: alpha-synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy.
abstract: Parkinson's disease (PD) and multiple system atrophy (MSA) are characterized pathologically by inclusions in the brain containing alpha-synuclein, which is phosphorylated at serine 129. alpha-Synuclein is present not only in the brain but also in platelets; platelets have previously been used to study mitochondrial function in PD. We undertook to determine whether alpha-synuclein extracted from platelets of patients with PD and MSA is phosphorylated at serine 129 and could be used as a peripheral marker of these disorders. Immunoblots indicated that platelet alpha-synuclein is not phosphorylated at serine 129 in PD and MSA.
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0662, USA. cshults@ucsd.edu
authors.forename: Clifford W
authors.initials: CW
authors.lastname: Shults
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Barrett
authors.forename: Deborah
authors.initials: D
authors.lastname: Fontaine
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D015153:Blotting, Western / Q000379:methods; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism*; D012694:Serine / Q000378:metabolism*; D051844:alpha-Synuclein / Q000097:blood*
chemical_list: D029681:Arabidopsis Proteins; D002352:Carrier Proteins; C097202:MBP1 protein, Arabidopsis; D051844:alpha-Synuclein; D012694:Serine