title: Progressive depletion of mtDNA in mitochondrial myopathy.
abstract: The authors studied seven patients with mitochondrial DNA (mtDNA) myopathy. Over time, there was a progressive depletion of mtDNA, which preferentially affected wild-type mitochondrial genomes. This suggests that loss of wild-type mtDNA is a major feature of mtDNA myopathy, and preventing wild-type mtDNA depletion has treatment implications.
authors.affiliation: Mitochondrial Research Group, Neurology, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
authors.forename: Steve E
authors.initials: SE
authors.lastname: Durham
authors.forename: Denise T
authors.initials: DT
authors.lastname: Brown
authors.forename: Douglass M
authors.initials: DM
authors.lastname: Turnbull
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Chinnery
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D017353:Gene Deletion; D006801:Humans; D008297:Male; D017240:Mitochondrial Myopathies / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial