title: Risk factors for the progression or persistence of untreated mild dysplasia of the uterine cervix.
abstract: To identify the factors that may predict the progression or persistence of untreated mild dysplasia of the uterine cervix, we performed a retrospective review of 118 patients with histologically verified mild dysplasia who underwent colposcopic biopsies between January 1999 and December 2003. Regression to normal occurred in 70.3%, progression to moderate dysplasia or worse occurred in 11.0%, and persistence of mild dysplasia occurred in 18.7%. In regression/progression analysis, progression of untreated mild dysplasia was 34.5% (10/29) in patients with high viral loads (> or =100 relative light units/positive control [RLU/PC]) and 4.5% (3/67) in those with low viral loads (1 to <100 RLU/PC) and negative human papillomavirus (HPV) tests (P < 0.001). Women with high viral loads had a 13-fold greater chance of progression of untreated mild dysplasia than those with low viral loads and negative HPV tests (CI: 2.494-95.297; P = 0.0022). Those associated with both positive smear and positive HPV test (12/45 = 26.7%) were at a greater risk of progression of untreated mild dysplasia as compared with those with positive smear and negative HPV (0/17 = 0.0%) or those with negative smear and positive HPV test (1/18 = 5.6%). Those with high viral loads and both with positive smear and positive HPV test should be followed closely because of their increased risk of progression of untreated mild dysplasia.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Korea University, Seoul.
authors.forename: S-H
authors.initials: SH
authors.lastname: Song
authors.forename: J-K
authors.initials: JK
authors.lastname: Lee
authors.forename: M-J
authors.initials: MJ
authors.lastname: Oh
authors.forename: J-Y
authors.initials: JY
authors.lastname: Hur
authors.forename: Y-K
authors.initials: YK
authors.lastname: Park
authors.forename: H-S
authors.initials: HS
authors.lastname: Saw
mesh_terms: D000328:Adult; D018196:Carcinoma, Adenosquamous / Q000235:genetics / Q000473:pathology / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology / Q000821:virology; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000235:genetics / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology*; D019562:Viral Load
chemical_list: D004279:DNA, Viral