Gene expression in fibroadenomas of the rat mammary gland in contrast to spontaneous adenocarcinomas and normal mammary gland.
Fibroadenomas are considered a benign lesion in rodent carcinogenicity studies. However, the entity adenocarcinoma arising in fibroadenoma does exist and in humans there is evidence of certain forms of fibroadenomas to confer greater risk of subsequent breast cancer. In this study, we aim to elucidate the molecular features of both spontaneous fibroadenomas and adenocarcinomas. The gene expression of the two tumour types is examined and compared to mammary gland in the same developmental state and examined for similarities which might indicate common molecular pathways. In the present study no similarities were discovered. We conclude that in the tumours examined here, no progression to adenocarcinoma is likely. Further studies are needed, examining a greater number of tumours and including cases of adenocarcinoma arising in fibroadenoma.
Marxfeld
Heike
H
Preclinical Safety, Novartis Pharma AG, Basel, Switzerland. heike.marxfeld@eur.crl.com
Staedtler
Frank
F
Harleman
Johannes H
JH
D000230:Adenocarcinoma / Q000235:genetics*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D005260:Female; D018226:Fibroadenoma / Q000235:genetics*; D020869:Gene Expression Profiling; D007150:Immunohistochemistry; D008321:Mammary Glands, Animal / Q000378:metabolism*; D015674:Mammary Neoplasms, Animal / Q000235:genetics*; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018800:Thy-1 Antigens / Q000032:analysis / Q000235:genetics
D018800:Thy-1 Antigens; D003094:Collagen; D010751:Phosphopyruvate Hydratase