[Relationship of hypoxia-induced factor with tumor angiogenesis in early liver metastasis in colonic cancer].
OBJECTIVE
To study the relationships of hypoxia-induced factor (HIF) with tumor angiogenesis and early liver metastasis in colonic cancer.


METHODS
Thirty three cases of colon cancer undergoing radical surgery were divided into two groups according to liver metastasis or not within half a year after operation. Expressions of HIF and vascular endothelial growth factor (VEGF) were examined using immunohistochemical method and tumor microvessel density (MVD) was measured in colonic cancer specimens.


RESULTS
Fifteen cases developed early liver metastasis, while 18 did not. The positive rates of HIF and VEGF, and MVD were 86.7%, 66.7%, (57.9+/- 12.7)% respectively in the group with early liver metastasis, significantly higher than 44.4% (P< 0.05), 27.8% (P< 0.05) and (22.3+/- 10.2)% (P< 0.01) respectively in the group without early liver metastasis respectively.


CONCLUSIONS
HIF can promote tumor angiogenesis in colonic cancer, and is closely related with early liver metastasis.
Liang
Hao-hui
HH
Department of General Surgery, Shenzhen Second People's Hospital, Shenzhen 518035, China.
Wang
Cheng-you
CY
Xu
Min
M
Cheng
Shu-bang
SB
D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D008113:Liver Neoplasms / Q000098:blood supply* / Q000556:secondary; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D051793:Hypoxia-Inducible Factor 1; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A