Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents.
We describe a novel class of benzocycloheptanone derived oxazolidinone antibacterial agents. The synthesis and antibacterial activities with structure variation is discussed.
Vara Prasad
J V N
JV
Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. Josyula.VaraPrasad@Pfizer.com
Boyer
Frederick E
FE
Chupak
Lou
L
Dermyer
Michael
M
Ding
Qizhu
Q
Gavardinas
K
K
Hagen
Susan E
SE
Huband
Michael D
MD
Jiao
Wenhua
W
Kaneko
Takushi
T
Maiti
Samarendra N
SN
Melnick
Michael
M
Romero
Karina
K
Patterson
M
M
Wu
Xiujuan
X
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001567:Benzocycloheptenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D001567:Benzocycloheptenes; D023303:Oxazolidinones