title: Arteriographic demonstration of slow antegrade opacification distal to a cerebrovascular thromboembolic occlusion site as a favorable indicator for intra-arterial thrombolysis.
abstract: OBJECTIVE
  This study sought to determine whether the angiographic demonstration of slow antegrade contrast opacification of an occluded cerebral artery distal to the thrombus (clot outline sign) on cerebral arteriograms performed immediately before thrombolytic treatment is associated with higher recanalization rates relative to patients without antegrade contrast opacification distal to the occlusion site.
  
  
  METHODS
  The angiographic images of 100 consecutive arteriograms performed before thrombolysis in patients eligible for intra-arterial thrombolysis from May 1995 to February 2005 were reviewed. A modified Thrombolysis in Myocardial Infarction flow grade (mTIMI) was adapted to grade recanalization after cerebral thrombolysis. Clot outline sign was defined as slow antegrade contrast opacification distal to the thrombus on the delayed images of the presenting arteriogram. Logistic regression analysis for mTIMI grade included the following potential predictors: presence of outline sign, age, time to treatment, sex, site of occlusion, presenting National Institutes of Health Stroke Scale (NIHSS) score, presenting platelets, presenting systolic blood pressure, presence of pial collaterals, and admitting glucose value.
  
  
  RESULTS
  Eighty-seven arteriograms were reviewed. Of these, 19 (22%) displayed the clot outline sign. Thirteen (69%) of 19 had clot outline sign, and 16 of 68 (29%) were not completely recanalized (mTIMI = 3); 95% with clot outline sign and 54% without were associated with either mTIMI 2 or 3 (P = .0055, Pearson correlation). Logistic regression analysis for recanalization relative to other predictors indicates that only the clot outline sign could act as a statistically significant predictor for recanalization (P = .0007).
  
  
  CONCLUSIONS
  Prethrombolysis cerebral arteriograms demonstrating delayed antegrade contrast opacification distal to the occlusion site are associated with higher recanalization rates.
authors.affiliation: Department of Radiology, The Ohio State University Medical Center, Columbus, OH 43210, USA. greg.christoforidis@osumc.edu
authors.forename: G A
authors.initials: GA
authors.lastname: Christoforidis
authors.forename: Y
authors.initials: Y
authors.lastname: Mohammad
authors.forename: B
authors.initials: B
authors.lastname: Avutu
authors.forename: A
authors.initials: A
authors.lastname: Tejada
authors.forename: A P
authors.initials: AP
authors.lastname: Slivka
mesh_terms: D000367:Age Factors; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003097:Collateral Circulation / Q000502:physiology; D003287:Contrast Media; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D007269:Injections, Intra-Arterial; D020766:Intracranial Embolism / Q000000981:diagnostic imaging* / Q000188:drug therapy; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D012189:Retrospective Studies; D020521:Stroke / Q000145:classification; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D003287:Contrast Media; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator