Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase.
Aldose reductase, the first key enzyme in the polyol pathway, is involved in complications of diabetes. Sclerotiorin, isolated and purified from the fermented broth of Penicillium frequentans, inhibited aldose reductase with an IC(50 )0.4 microM. The inhibitor also showed antibacterial activity against Bacillus spp.
Chidananda
C
C
Fermentation Technology and Bioengineering Department, Central Food Technological Research Institute, Mysore, 570020, India.
Rao
L Jagan Mohan
LJ
Sattur
A P
AP
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D001578:Benzopyrans / Q000494:pharmacology*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology; D010407:Penicillium / Q000737:chemistry*; D051381:Rats
D000900:Anti-Bacterial Agents; D001578:Benzopyrans; C101449:sclerotiorin; D000449:Aldehyde Reductase