title: [Extensive cutaneous candidiasis revealing cutaneous T-cell lymphoma: 2 cases].
abstract: BACKGROUND
  During the course of immunodeficiency diseases, severe candidiasis can occur with extensive cutaneous and mucous membrane lesions. However, blood dyscrasias are very rarely revealed by diffuse candidiasis. We report two case of cutaneous T-cell lymphoma revealed by extensive and atypical cutaneous candidiasis.
  
  
  METHODS
  Case No. 1:A 72-year-old woman presented a pruritic rash of circinate, serpiginous patches on glabrous skin and skinfolds with multiple intertrigo and rapidly worsening palmoplantar keratoderma. All mycological skin specimens tested positive for Candida albicans. Histological examination of a biopsy sample from a serpiginous patch revealed the presence of fungal elements while palmoplantar keratoderma biopsy showed an epidermotropic lymphocytic infiltrate in the superficial dermis evocative of mycosis fungoides. Blood tests showed a white cell count of 28 600/mm3 with 14% circulating Sezary cells and a T-cell clone. The T-cell lymphoma was treated with methotrexate, but the disease worsened a few months later, progressing to CD30- large T-cell pleomorphic lymphoma. The patient died of severe sepsis. Case No 2:A 60-year-old man presented a macular rash over the face, trunk and skinfolds as well as erythematous scaly annular plaques of the glabrous skin with lymphadenopathy. Cultures of skin scrapings were all positive for Candida albicans. Blood tests showed a white cell count of 15 000/mm3 with 30% circulating Sezary cells. A trunk patch biopsy revealed the histological appearance of mycosis fungoides. There was a T-cell clone in the peripheral blood and skin.
  
  
  CONCLUSIONS
  In both cases, the patients presented with widespread annular and erythematous scaly lesions of the glabrous skin and skinfolds with evidence of Candida albicans on fungal tests of all skin scrapings. The discovery of circulating Sezary cells on a systematic smear for hyperleukocytosis led us to suspect underlying cutaneous T-cell lymphoma, which was confirmed by biopsy of the skin lesions accompanying the mycoses. Widespread cutaneous candidiasis can occur in patients with cell-mediated immunodepression. Cutaneous T-cell lymphoma can enhance such candidiasis through interference with skin integrity and impairment of cell-mediated immunity, with large amounts of IL10 and TGF-B, increased secretion of soluble interleukin-2 receptors (CD25) and impaired CD8 suppressor cell function.
authors.affiliation: Service de Dermatologie, Centre Hospitalier Victor Dupouy, Argenteuil.
authors.forename: T
authors.initials: T
authors.lastname: Duong
authors.forename: S
authors.initials: S
authors.lastname: Ingen-Housz-Oro
authors.forename: A
authors.initials: A
authors.lastname: Gaulier
authors.forename: A
authors.initials: A
authors.lastname: Petit
authors.forename: L
authors.initials: L
authors.lastname: Dubertret
authors.forename: M
authors.initials: M
authors.lastname: Sigal-Grinberg
mesh_terms: D000368:Aged; D002179:Candidiasis, Cutaneous / Q000150:complications*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis*