Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study.
The authors studied the association of markers of inflammation with the later development of Parkinson disease (PD) using a case-control design (196 cases and 196 matched controls). The frequency of diseases of immediate-type hypersensitivity was significantly higher in cases than controls. In addition, cases used anti-inflammatory agents less frequently than controls (nonsignificant trend). The results may support the hypothesis that there is an inflammatory component in the pathogenesis of PD.
Bower
J H
JH
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. bower.james@mayo.edu
Maraganore
D M
DM
Peterson
B J
BJ
Ahlskog
J E
JE
Rocca
W A
WA
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007154:Immune System Diseases; D007249:Inflammation / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D010300:Parkinson Disease / Q000209:etiology* / Q000276:immunology
D000893:Anti-Inflammatory Agents