[Treatment results in children with the standard risk acute lymphoblastic leukemia treated with high dose of methotrexate (5.0 g/m2). 11 years of the Polish Pediatric Leukemia/Lymphoma Study Group experience].
Since 01.07.1993 to 30.09.2004, 675 children with ALL-SR were diagnosed and treated according to the modified ALL-BFM 90 protocol. Subject to statistical analysis (Kaplan-Meier method) were thus 197 children with ALL-SR treated with HD-MTX in a dose 5.0g/ m2. Among them, 21 patients failed to respond to therapy: 2 (1.0%) early deaths, 2 (1.0%) deaths during I complete remission, 16 (8.2%) relapses, 1 (0.5%) second neoplasm. Relapses occured: 12 (6.2%) in bone marrow, 2 (1.0%) in central nervous system, 1 (0.5%) in testicle and in 1 (0.5%) child combined relapse was observed. Probability rates for 11-year event free survival (EFS) was 0.80 (0.03). Application of high dose of methotrexate is safety and effective in prevention of relapses, especially meningeal and testicular involvement.
Derwich
Katarzyna
K
Klinika Onkologii, Hematologii i Transplantologii Pediatrycznej, II Katedry Pediatrii AM 60-572 Poznań, ul. Szpitalna 27/33. kderwich@poczta.onet.pl
Wachowiaki
Jacek
J
Kaczmarek-Kanoldi
Małgorzata
M
Balcerska
Anna
A
Balwierz
Walentyna
W
Chybicka
Alicja
A
Kowalczyk
Jerzy R
JR
Matysiak
Michał
M
Jackowska
Teresa
T
Sońta-Jakimczyk
Danuta
D
Wysocki
Mariusz
M
Chełmecka-Hanuszewicz
Lidia
L
Cwiklińska
Magdalena
M
Kołtan
Andrzej
A
Malinowska
Iwona
I
Odój
Teresa
T
Płoszyńska
Anna
A
Steczowicz
Monika
M
Wojciechowska
Violeta
V
Wójtowicz
Anna
A
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D018572:Disease-Free Survival; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D011044:Poland / Q000453:epidemiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000453:epidemiology / Q000401:mortality; D012189:Retrospective Studies; D016896:Treatment Outcome
D008727:Methotrexate