title: Understanding eating disorders.
abstract: The outcome in eating disorders remains poor and commonly used methods of treatment have little, if any effect. It is suggested that this situation has emerged because of the failure to realize that the symptoms of eating disorder patients are epiphenomena to starvation and the associated disordered eating. Humans have evolved to cope with the challenge of starvation and the neuroendocrine mechanisms that have been under this evolutionary pressure are anatomically versatile and show synaptic plasticity to allow for flexibility. Many of the neuroendocrine changes in starvation are responses to the externally imposed shortage of food and the associated neuroendocrine secretions facilitate behavioral adaptation as needed rather than make an individual merely eat more or less food. A parsimonious, neurobiologically realistic explanation why eating disorders develop and why they are maintained is offered. It is suggested that the brain mechanisms of reward are activated when food intake is reduced and that disordered eating behavior is subsequently maintained by conditioning to the situations in which the disordered eating behavior developed via the neural system for attention. In a method based on this framework, patients are taught how to eat normally, their physical activity is controlled and they are provided with external heat. The method has been proven effective in a randomized controlled trial.
authors.affiliation: Karolinska Institutet, Section of Applied Neuroendocrinology, Center for Eating Disorders, AB Mando, Novum, S-141 57 Huddinge, Sweden. per.sodersten@ki.se
authors.forename: Per
authors.initials: P
authors.lastname: Södersten
authors.forename: Cecilia
authors.initials: C
authors.lastname: Bergh
authors.forename: Michel
authors.initials: M
authors.lastname: Zandian
mesh_terms: D000855:Anorexia / Q000235:genetics / Q000503:physiopathology; D005075:Biological Evolution; D001921:Brain / Q000502:physiology; D002032:Bulimia / Q000503:physiopathology; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents