title: Mansonella perstans causing symptomatic hypereosinophilia in a missionary family.
abstract: Mansonella perstans is rarely pathogenic. The rare reports of symptomatic cases, however, include severe complications. Three cases of symptomatic hypereosinophilia with multi-organ involvement are described in a missionary family returning from tropical Africa. Pathogenicity may be related to the induction of hypereosinophilia rather than direct host-parasite interactions.
authors.affiliation: Institute for Infectious Diseases, University of Bern, Friedbühlstrasse 51, CH-3010 Bern, Switzerland.
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Fux
authors.forename: Bernard
authors.initials: B
authors.lastname: Chappuis
authors.forename: Benedikt
authors.initials: B
authors.lastname: Holzer
authors.forename: Christoph
authors.initials: C
authors.lastname: Aebi
authors.forename: Gerard
authors.initials: G
authors.lastname: Bordmann
authors.forename: Hanspeter
authors.initials: H
authors.lastname: Marti
authors.forename: Christoph
authors.initials: C
authors.lastname: Hatz
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D005260:Female; D005369:Filaricides / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000469:parasitology; D007559:Ivermectin / Q000627:therapeutic use; D008297:Male; D008366:Mansonella / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification*; D008368:Mansonelliasis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D066189:Missionaries; D008944:Mitral Valve Insufficiency / Q000209:etiology* / Q000601:surgery; D011239:Prednisolone / Q000627:therapeutic use; D008921:Religious Missions; D014195:Travel; D016896:Treatment Outcome
chemical_list: D005369:Filaricides; D007559:Ivermectin; D011239:Prednisolone