7-Hydroxystaurosporine may have a therapeutic role in treatment-resistant depression by inhibition of calcium/calmodulin-dependent protein kinase II.
Emanuele
Enzo
E
Arra
Mariarosa
M
Bertona
Marco
M
D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism*; D004351:Drug Resistance; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*; D019311:Staurosporine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017211:Treatment Failure
D047428:Protein Kinase Inhibitors; C054852:7-hydroxystaurosporine; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019311:Staurosporine