Phylogenetic background and carriage of pathogenicity island-like domains in relation to antibiotic resistance profiles among Escherichia coli urosepsis isolates.
We studied 100 well-characterized E. coli blood isolates from patients with urosepsis for their susceptibility to nalidixic acid, ampicillin and trimethoprim-sulfamethoxazole, according to prevalence of virulence factors, phylogenetic groups and subgroups, PAI II(J96)-like domains (determined by physical linkage of cnf1, hly and hra) and PAI I(CFT073)-like domains (determined by physical linkage of papGII to the hly locus). Nalidixic acid resistance was associated with a lower prevalence of sfa/foc, K1 antigen, pathogenicity island II(J96)-like domains, subgroup B2/I and a shift towards group A.
Houdouin
Véronique
V
Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA3105), Université Denis Diderot-Paris 7 AP-HP, Hôpital Robert Debré, Service de Microbiologie, 75019 Paris, France.
Bonacorsi
Stéphane
S
Bidet
Philippe
P
Bingen-Bidois
Martine
M
Barraud
Dominique
D
Bingen
Edouard
E
D000667:Ampicillin / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology; D044404:Genomic Islands / Q000235:genetics*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D018805:Sepsis / Q000382:microbiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics*
D000890:Anti-Infective Agents; D037521:Virulence Factors; D009268:Nalidixic Acid; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination