title: Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way.
abstract: The possibility for the application of organic synthesis to the discovery of new agents in combating neurodegenerative disorders is described. Our focus has been on agents derived from natural-product leads and natural products themselves prepared through total synthesis. Herein, we describe some of the chemistry as well as interesting observations made along the way.
authors.affiliation: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Wilson
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry; D004149:Dioxoles / Q000138:chemical synthesis / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C516856:11-O-debenzoyltashironin; D001688:Biological Products; D001952:Bridged-Ring Compounds; D004149:Dioxoles; D004224:Diterpenes; D007783:Lactones; C466781:NGA 0187; D012717:Sesquiterpenes; D013729:Terpenes; D014315:Triterpenes; C106690:garsubellin A; C457979:jiadifenin; C458341:merrilactone A; C119787:scabronine G; C098157:tricycloillicinone