[Treatment of male adrenogenital syndrome (report of 17 cases)].
OBJECTIVE
To discuss the treatment of male adrenogenital syndrome.


METHODS
The clinical data of 17 patients with male adrenogenital syndrome, including 15 cases of congenital adrenal hyperplasia (CAH) and 2 cases of adrenocortical tumors, were analyzed retrospectively. The patients with 21-hydroxylase deficiency (21-OHD) and 11beta-hydroxylase deficiency (11beta-OHD) were treated with adrenocortical hormone, those with 17-hydroxylase deficiency (17-OHD) received sexual glands excision and estrogen besides adrenocortical hormone, and those with adrenocortical tumors underwent surgical removal.


RESULTS
Sexual precocity symptoms disappeared and abnormal laboratory results returned to normal in 5 of the 21-OHD patients, who adhered to hormone treatment, and height growth was improved in the other 2, who received the medicine at an early age. The testicular adrenal rest (TAR) tumor was reduced dramatically in 1 case of 21-OHD after treatment. A left TAR found in another 21-OHD patient who discontinued the hormone therapy became softened after the resumption. Sperm could be seen in the semen of 3 21-OHD patients, but in small quantity and of poor quality. One 11beta-OHD patient with sexual precocity symptoms and hypertension became normal after the hormone treatment, and six 17-OHD patients maintained their female sexuality after the hormone treatment and operation. No relapse was found after resection of the adrenocortical tumors.


CONCLUSIONS
Adrenocortical hormone therapy helps improve the height growth and testicular function of CAH patients, and surgical removal is necessary for adrenocortical tumors.
Liu
Guang-hua
GH
Department of Urology, Peking Union Hospital, China Union Medical University, Chinese Academy of Medical Science, Beijing 100730, China. pumchliuguanghwa@sina.com
Li
Han-zhong
HZ
Li
Yong-qiang
YQ
Ji
Zhi-gang
ZG
Jin
Wei
W
Li
Hong-jun
HJ
D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000601:surgery; D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy; D047808:Adrenogenital Syndrome / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies
D005938:Glucocorticoids