title: Bias-dependent admittance in hybrid bilayer membranes.
abstract: Artificial bilayer membranes provide a platform for bioelectronic devices based on their structural, sensing, and transport functions. In this letter, we report on the impedance response of an engineered membrane with a lower leaflet of octadecanethiol on gold and an outer leaflet of dioleoylphosphatidylcholine with the monomeric channel protein gramicidin. This hybrid bilayer exhibits an electrical response analogous to a solid-state diode: the admittance is very low (<10(-)(7) Omega(-)(1) cm(-)(2)) over a wide potential range but increases exponentially at negative potentials.
authors.affiliation: Department of Materials Science and Engineering, and Institute of NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors.forename: Vesselin
authors.initials: V
authors.lastname: Nikolov
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Radisic
authors.forename: Kalina
authors.initials: K
authors.lastname: Hristova
authors.forename: Peter C
authors.initials: PC
authors.lastname: Searson
mesh_terms: D006046:Gold / Q000737:chemistry*; D006096:Gramicidin / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000737:chemistry*; D008567:Membranes, Artificial; D008958:Models, Molecular; D010713:Phosphatidylcholines / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D013438:Sulfhydryl Compounds; D006096:Gramicidin; C055360:n-octadecyl mercaptan; D006046:Gold; C017251:1,2-oleoylphosphatidylcholine