Preparation and physical characterization of a novel marine oil emulsion as a potential new formulation vehicle for lipid soluble drugs.
Emulsions often contain vegetable oils such as soybean oil. In this study, a 10% (w/w) of marine mammal oil emulsion was prepared. The effect of a group of emulsifying agents on the stability of the 10% of seal oil emulsion was examined. The emulsifying agents studied were hydrogenated castor oil coated with various polyoxyethylene derivatives. It was found that 2.5% of HCO-40 resulted in the most stable seal oil emulsion. The size of the emulsified droplets defined by their diameters was found to be around 240-270 nm. The initial zeta-potential and pH value of the emulsion were found to be around -27 mV and 3.5, respectively, which decreased over time, to about -31 mV and 2.4, respectively. This is believed to be a result of the hydrolysis of triacylglycerides into free fatty acids in the emulsion. The effect of various amounts of Crodasinic LS-30, a negatively charged surfactant, and Incroqal Behenyl TMS, a positively charged surfactant, on the emulsion was investigated. It was shown that Crodasinic LS-30 had very little effect on the particle size, zeta-potential and pH, while the effect of Incroquat Benhenyl TMS was found to be dependent upon the concentration of the surfactant used.
Cui
Guohui
G
School of Pharmacy, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6.
Wang
Lili
L
Davis
Philip J
PJ
Kara
Mohameditaki
M
Liu
Hu
H
D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D045703:Emulsifying Agents / Q000737:chemistry; D004655:Emulsions; D005227:Fatty Acids / Q000737:chemistry*; D015525:Fatty Acids, Omega-3 / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D009821:Oils / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D046048:Seals, Earless; D012995:Solubility; D055672:Static Electricity
D004337:Drug Carriers; D045703:Emulsifying Agents; D004655:Emulsions; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D009821:Oils; D014677:Pharmaceutical Vehicles