title: Two new bioactive sesquiterpenes from the soft coral Sinularia sp.
abstract: Two new sesquiterpenes, 1S*, 4R*, 5S*, 6R*, 7S*, 10S*-1(5), 6(7)-diepoxy-4-guaiol (1) and 1S*, 4S*, 5S*, 10R*-4,10-guaianediol (2) have been isolated from the ethyl acetate soluble portion of the soft coral Sinularia sp., and their stereostructure were determined by spectroscopic methods and by X-ray single crystal analysis. Both compounds showed antioxidant and cytotoxic activities.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Zhang
authors.forename: Xiang-Quan
authors.initials: XQ
authors.lastname: Ma
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Su
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurihara
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Long-Mei
authors.initials: LM
authors.lastname: Zeng
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D012717:Sesquiterpenes