title: Evidence of a genetic basis of Morgagni-Stewart-Morel syndrome. A case report of identical twins.
abstract: We report two 71-year-old female monozygotic twins presenting with advanced hyperostosis frontalis interna, obesity, shortness and cognitive impairment. They both have suffered from generalized seizures since their early adulthood. Moreover, the patients showed some additional conditions only occurring in one individual or the other such as migraine, marked recurrent depressive disorder or polyarthrosis. The symptoms common to both twins appear to correspond to the Morgagni-Stewart-Morel syndrome and indicate a genetic basis of this disorder as these features occur in genetically identical patients.
authors.affiliation: Division of Psychiatry Research, University of Zurich, Zurich, Switzerland. miko1@gmx.ch
authors.forename: Michael F
authors.initials: MF
authors.lastname: Koller
authors.forename: Andreas
authors.initials: A
authors.lastname: Papassotiropoulos
authors.forename: Katharina
authors.initials: K
authors.lastname: Henke
authors.forename: Britta
authors.initials: B
authors.lastname: Behrends
authors.forename: Shigeru
authors.initials: S
authors.lastname: Noda
authors.forename: Adelgunde
authors.initials: A
authors.lastname: Kratzer
authors.forename: Christoph
authors.initials: C
authors.lastname: Hock
authors.forename: Marc
authors.initials: M
authors.lastname: Hofmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D006957:Hyperostosis Frontalis Interna / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D018433:Twin Studies as Topic; D014430:Twins, Monozygotic