Tandem mass spectra of ammonium adducts of monosaccharides: differentiation of diastereomers.
Tandem mass spectra of ammonium adducts of monosaccharides gave characteristic fragmentation patterns involving elimination of NH3/H2O followed by multiple eliminations of H2O and cross ring cleavages. Tandem mass spectra were examined over a range of collision energies (1-20 eV) on a triple-quadrupole mass spectrometer. The breakdown behavior of the ammonium adducts revealed patterns that could differentiate diastereomers of monosaccharides.
Madhusudanan
K P
KP
Sophisticated Analytical Instrument Facility, Central Drug Research Institute, Lucknow-226001, India. kpmadhusudanan@hotmail.com
D005947:Glucose / Q000737:chemistry; D007553:Isotope Labeling; D009005:Monosaccharides / Q000737:chemistry*; D011522:Protons; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism; D053719:Tandem Mass Spectrometry
D009005:Monosaccharides; D011522:Protons; D000644:Quaternary Ammonium Compounds; D005947:Glucose