Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor.
Pellicciari
Roberto
R
Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo 1, 06123 Perugia, Italy. rp@unipg.it
Rizzo
Rosa C
RC
Costantino
Gabriele
G
Marinozzi
Maura
M
Amori
Laura
L
Guidetti
Paolo
P
Wu
Hui-Qiu
HQ
Schwarcz
Robert
R
D000613:Aminobutyrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007737:Kynurenine / Q000378:metabolism*; D051381:Rats; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology*; D000637:Transaminases / Q000037:antagonists & inhibitors*; D014364:Tryptophan / Q000378:metabolism*
C515021:4-(ethylsulfonyl)benzoylalanine; D000613:Aminobutyrates; D004791:Enzyme Inhibitors; D013450:Sulfones; D007737:Kynurenine; D014364:Tryptophan; D000637:Transaminases; C021481:kynurenine-oxoglutarate transaminase