title: New perfluoroalkylated amphiphilic methacrylates bearing sulfinyl group as monomers for biomedical applications: water content and oxygen permeability of their copolymers with DEGMA.
abstract: Perfluoroalkylated methacrylates 7a-c bearing sulfinyl group within a straight-chain ester group, i.e. CH(2)=C(CH(3))CO(2)CH(2)CH(2)S(O)-CH(2)CH(2)CF(2)(CF(2)CF(2))(n)CF(3) (n=1-3) were prepared by two alternative synthetic sequences from 2-[(polyfluoroalkyl)sulfanyl]ethanols HOCH(2)CH(2)SCH(2)CH(2)CF(2)(CF(2)CF(2))(n)CF(3) (n=1-3) in overall yields of 88-91%. Copolymers of 7a-c with diethylene glycol methacrylate (DEGMA) prepared in bulk under radical conditions display high transparency, increased water content and good oxygen permeability properties, which are advantageous for their application in ophthalmology and as prosthetic materials.
authors.affiliation: Institute of Chemical Process Fundamentals, Academy of Sciences, Rozvojová 135, 16502 Prague 6, Czech Republic.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Církva
authors.forename: Jan
authors.initials: J
authors.lastname: Duchek
authors.forename: Robert
authors.initials: R
authors.lastname: Kaplánek
authors.forename: Oldrich
authors.initials: O
authors.lastname: Paleta
authors.forename: Jirí
authors.initials: J
authors.lastname: Michálek
authors.forename: Martin
authors.initials: M
authors.lastname: Prádný
authors.forename: Dana
authors.initials: D
authors.lastname: Chmelíková
authors.forename: Jana
authors.initials: J
authors.lastname: Wichterlová
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D005466:Fluorocarbons / Q000138:chemical synthesis / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D010539:Permeability; D012031:Refractometry; D013499:Surface Properties
chemical_list: C512139:2-(2-hydroxyethoxy)ethyl methacrylate; D001672:Biocompatible Materials; D005466:Fluorocarbons; D008689:Methacrylates