The role of immune tolerance in asthma pathogenesis.
Immune-mediated tolerance encompasses a wide spectrum of mechanisms that can prevent unnecessary and potentially harmful inflammatory responses. An increasing number of scientific publications provide proof for the concept that an impairment of immune-tolerance mechanisms might be causally related to the development of unwanted Th2-driven, allergen-induced airway diseases. In this review, we discuss immune tolerance and the evidence supporting its role in asthma pathogenesis.
Tournoy
Kurt G
KG
Ghent University Hospital, Department of Respiratory Diseases, Gent, Belgium. Kurt.tournoy@UGENT.be
Provoost
Sharen
S
Van Hove
Chris
C
Joos
Guy
G
D000818:Animals; D001249:Asthma / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors