title: Usefulness of translesional pressure gradient and pharmacological provocation for the assessment of intermediate renal artery disease.
abstract: OBJECTIVE
  We sought to determine the hemodynamic significance of intermediate RAS by measuring translesional systolic pressure gradients (TSPG), using a pressure-sensing guidewire at baseline and after acetylcholine (ACh) induced hyperemia, following selective renal artery angiography.
  
  
  BACKGROUND
  Renal artery stenosis (RAS) is a cause of reversible hypertension and nephropathy. Stenting effectively relieves RAS, however improvement in blood pressure control or renal function is variable and unpredictable. Hemodynamic significance is usually present with RAS when diameter stenosis is >75%, but is less predictable in intermediate (30%-75%) RAS.
  
  
  METHODS
  Twenty-two patients (26 renal arteries) with uncontrolled hypertension underwent invasive hemodynamic assessment because of intermediate RAS, defined as radiocontrast angiographic diameter stenosis (DS) between 30% and 75% (quantitative DS was measured prospectively). Translesional pressure gradients were measured using a 0.014" pressure-sensing wire. Hyperemia was induced by administration of intrarenal ACh.
  
  
  RESULTS
  Visual and measured angiographic lesion severity did not correlate with TSPG either at baseline (visual DS, R(2) = 0.091, P = 0.13; measured DS, R(2) = 0.124, P = 0.07) or with hyperemia (visual DS, R(2) = 0.057, P = 0.24; measured DS, R(2) = 0.101, P = 0.12). Baseline and maximal hyperemic gradient did correlate (R(2) = 0.567; P < 0.05). Pharmacological provocation produced a significant increase in TSPG (mean; baseline, 18 +/- 21 vs. hyperemia, 34 +/- 41 mm Hg; P < 0.05). A hemodynamically significant lesion (TSPG > 20 mm Hg) was found in 14/26 (54%) arteries (13 patients); 13 (60%) patients subsequently underwent renal artery stenting for hemodynamically significant RAS. At follow-up (at least 30 days), there was a significant decrease in systolic blood pressure (mean; 167 +/- 24 vs. 134 +/- 19 mm Hg; P < 0.001).
  
  
  CONCLUSIONS
  Intrarenal administration of ACh induces hyperemia and can be used to unmask resistive renal artery lesions. Gradient measurement and induced hyperemia may be warranted in the invasive assessment of intermediate renal artery stenoses, rather than relying on stenosis severity alone. Further study is needed to determine whether translesional pressure gradients and pharmacological provocation predict clinical benefit after renal artery stenting.
authors.affiliation: Cardiovascular Center, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Noah J
authors.initials: NJ
authors.lastname: Jones
authors.forename: Eric R
authors.initials: ER
authors.lastname: Bates
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Chetcuti
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lederman
authors.forename: P Michael
authors.initials: PM
authors.lastname: Grossman
mesh_terms: D000109:Acetylcholine / Q000009:adverse effects*; D000368:Aged; D000792:Angiography / Q000379:methods; D001794:Blood Pressure / Q000187:drug effects; D019917:Blood Vessel Prosthesis Implantation; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012078:Renal Artery Obstruction / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D012720:Severity of Illness Index; D015607:Stents; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D003287:Contrast Media; D014665:Vasodilator Agents; D000109:Acetylcholine