title: Evaluation of sympathetic re-innervation in heterotopic cardiac transplants by iodine-123-metaiodobenzylguanidine (I-123-MIBG) imaging.
abstract: Scintigraphy using iodine-123-metaiodobenzylguanidine (I-123-MIBG) has been used to demonstrate that >50% of orthotopically transplanted hearts undergo partial cardiac sympathetic re-innervation and that this occurs no earlier than 1 year post-transplant. This study used planar and singe-photon emission computed tomography (SPECT) I-123 MIBG scintigraphy to show that cardiac re-innervation was not detectable in any of the 8 patients studied 1.1 to 6.3 years post-heterotopic transplantation. Thus, potential for cardiac re-innervation varies according to the type of procedure performed.
authors.affiliation: Department of Nuclear Medicine, The Alfred Hospital, Melbourne, Australia. kskyap@yahoo.com
authors.forename: Kenneth S K
authors.initials: KS
authors.lastname: Yap
authors.forename: Paul
authors.initials: P
authors.lastname: Gould
authors.forename: Victor
authors.initials: V
authors.lastname: Kalff
authors.forename: David M
authors.initials: DM
authors.lastname: Kaye
authors.forename: Don
authors.initials: D
authors.lastname: Esmore
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kelly
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D000368:Aged; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation*; D016027:Heart Transplantation; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine