title: Pattern and factors affecting management outcome of spina bifida cystica in Ile-Ife, Nigeria.
abstract: OBJECTIVE
  There is paucity of data on the pattern and factors affecting the management outcome of patients with spina bifida cystica in the Ife-Ijesa zone, Nigeria. This study was designed to address this research question.
  
  
  METHODS
  One hundred and six consecutive cases of spina bifida cystica who presented in our hospital from January 1990 to December 2004 were reviewed. We obtained information on sociodemographic factors, medical history and management as well as clinical outcome. SPSS was used to analyze the data.
  
  
  RESULTS
  Males constituted 54.7% and females 45.2% of cases. Mortality was high in those presented after the 4th week of life (p = 0.04). The malformation occurred in the lumbar and lumbosacral regions in 77.4%. Myelomeningocele was the most common type (86.8%). Hydrocephalus was recorded in 53.8% of patients. Surgical closure was done for 91.5% of the patients. About 77% of all the patients were discharged while 22.7% died. This was significantly related to age at presentation (p = 0.04) and infection before surgery (p = 0.045). Postoperative complications were more frequent in patients with ruptured lesions (p = 0.025), a larger size of defect (p = 0.028) and a lower birth weight (p = 0.006).
  
  
  CONCLUSIONS
  Myelomeningocele is the most common type of spina bifida cystica in our environment. Late presentation and preoperative infection are associated with high mortality in our patients.
authors.affiliation: Department of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: O I
authors.initials: OI
authors.lastname: Alatise
authors.forename: A A
authors.initials: AA
authors.lastname: Adeolu
authors.forename: E O
authors.initials: EO
authors.lastname: Komolafe
authors.forename: O
authors.initials: O
authors.lastname: Adejuyigbe
authors.forename: O A
authors.initials: OA
authors.lastname: Sowande
mesh_terms: D000015:Abnormalities, Multiple; D001724:Birth Weight; D005190:Family / Q000523:psychology; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D017052:Hospital Mortality; D006801:Humans; D006849:Hydrocephalus / Q000453:epidemiology / Q000601:surgery; D007231:Infant, Newborn; D008297:Male; D008591:Meningomyelocele / Q000453:epidemiology / Q000601:surgery; D009549:Nigeria / Q000453:epidemiology; D017063:Outcome Assessment, Health Care; D008517:Phytotherapy / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology; D011295:Prenatal Care; D012421:Rupture; D017678:Sex Distribution; D016137:Spina Bifida Cystica / Q000453:epidemiology* / Q000601:surgery; D013315:Stress, Psychological / Q000453:epidemiology; D013997:Time Factors; D017287:Ventriculoperitoneal Shunt; D014803:Vitamin B Complex / Q000008:administration & dosage
chemical_list: D014803:Vitamin B Complex; D005492:Folic Acid