Antidiabetic activity of Caesalpinia bonducella seed extracts in rats.
The seed extracts of Caesalpinia bonducella were subjected to screening of antidiabetic activity in alloxan induced hyperglycemia. The oral administration of the extracts (300 mg/kg) produced significant antihyperglycemic action as well as it lowered the BUN levels significantly. In the same study the action of the extracts on diabetes induced hyperlipidemia was analyzed where the extracts significantly lowered the elevated cholesterol as well as LDL level. The antihyperglycemic action of the extracts may be due to the blocking of glucose absorption. The drug has the potential to act as antidiabetic as well as antihyperlipidemic.
Kannur
D M
DM
Department of Pharmacognosy and Phytochemistry, MAEER'S Maharashtra Institute of Pharmacy, Kothrud, Pune 411030, India. dmkannur@rediffmail.com
Hukkeri
V I
VI
Akki
K S
KS
D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001806:Blood Urea Nitrogen; D029911:Caesalpinia; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D000496:Alloxan; D002784:Cholesterol; D003404:Creatinine