Antiplasmodial activity of Homalium letestui.
The in vivo antiplasmodial activity of the ethanol root extract of Homalium letestui used as a malaria remedy in Southern Nigeria was evaluated in Plasmodium berghei berghei infected mice. Homalium letestui root extract (500-1000 mg/kg/day) exhibited significant (p < 0.05) blood schizontocidal activities both in a 4-day early infection test and in an established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The root extract possesses significant (p < 0.05) antiplasmodial activity, which can be exploited in malaria therapy.
Okokon
Jude E
JE
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com
Ita
Basil
B
Udokpoh
Aniekan E
AE
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D005260:Female; D007928:Lethal Dose 50; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D010962:Plasmodium berghei / Q000187:drug effects*; D031308:Salicaceae / Q000737:chemistry*; D016019:Survival Analysis; D013997:Time Factors
D000981:Antiprotozoal Agents; D010936:Plant Extracts; D000431:Ethanol