Non-pathogenic anti-desmoglein 3 IgG autoantibodies in Fogo Selvagem.
The endemic form of pemphigus foliaceus, fogo selvagem, is caused by IgG autoantibodies directed against desmoglein 1 (Dsg1). Hilario-Vargas and his colleagues describe a high prevalence of IgG autoantibodies against Dsg3, the target antigen of pemphigus vulgaris, in a Brazilian population where fogo selvagem is endemic, although those patients do not develop any apparent clinical phenotype of pemphigus vulgaris.
Amagai
Masayuki
M
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan. amagai@sc.itc.keio.ac.jp
D001323:Autoantibodies / Q000276:immunology*; D051184:Desmoglein 3 / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D010392:Pemphigus / Q000453:epidemiology / Q000276:immunology*; D016036:Seroepidemiologic Studies
D001323:Autoantibodies; D051184:Desmoglein 3; D007074:Immunoglobulin G