Progressive depletion of mtDNA in mitochondrial myopathy.
The authors studied seven patients with mitochondrial DNA (mtDNA) myopathy. Over time, there was a progressive depletion of mtDNA, which preferentially affected wild-type mitochondrial genomes. This suggests that loss of wild-type mtDNA is a major feature of mtDNA myopathy, and preventing wild-type mtDNA depletion has treatment implications.
Durham
Steve E
SE
Mitochondrial Research Group, Neurology, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Brown
Denise T
DT
Turnbull
Douglass M
DM
Chinnery
Patrick F
PF
D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D017353:Gene Deletion; D006801:Humans; D008297:Male; D017240:Mitochondrial Myopathies / Q000235:genetics*
D004272:DNA, Mitochondrial