title: [The treatment of extensive onychomycosis in aged patients].
abstract: The aim of the study was to present the own observations concerning treatment of patients above 50 years of age suffering the toe nail dermatophyte onychomycosis with intensified subungual keratosis and considerable nail plates destruction. Three different treatment methods were administered: 40 patients were treated only with itraconazole pulse method for 3 month, 35 patients besides itraconazole were given also pentoxifylline. In case of 20 individuals besides 3-month itraconazole pulse method treatment, the amorolfine varnish application onto changed nails once a week for 6 month was administered. In the group of patients treated only with itraconazole, in 22 cases (55,0%) the cure was obtained, while in the group of individuals given the combined therapy with pentoxifylline, the cures made 71,4% (25 individuals). From among patients treated with itraconazole and external amorolfine application the cures made 75,0% (15 individuals).
authors.affiliation: Oddział Dermatologiczny Szpitala MSWiA, 60-631 Poznań, ul. Dojazd 34.
authors.forename: R
authors.initials: R
authors.lastname: Maleszka
authors.forename: Z
authors.initials: Z
authors.lastname: Adamski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000188:drug therapy* / Q000473:pathology; D006229:Hand Dermatoses / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use*; D009262:Nails / Q000378:metabolism / Q000382:microbiology; D014009:Onychomycosis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009025:Morpholines; D017964:Itraconazole; C038974:amorolfine