Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia: a comparative study.
OBJECTIVE
To evaluate and compare the effect of two clinically available central nervous system stimulants, namely doxapram and aminophylline on arousal from sevoflurane anaesthesia and bispectral index.


METHODS
This randomized, double-blind, placebo-controlled, prospective study was conducted in 90 adult females, ASA I-II, scheduled for elective lower abdominal surgeries at Taipei Medical University Hospital. At 5 min before the completion of surgery, under sevoflurane anaesthesia, patients were divided into three groups to receive doxapram 1 mg kg(-1), aminophylline 2 mg kg(-1) or saline placebo intravenous. Standard vital signs, end-tidal CO(2), end-expiratory sevoflurane concentration, bispectral index and neuromuscular blockade were measured plus clinical parameters of recovery from general anaesthesia.


RESULTS
Compared with the control group, patients receiving doxapram or aminophylline showed a similarly faster recovery from sevoflurane anaesthesia correlated with increase in bispectral index.


CONCLUSIONS
Intravenous administration of doxapram 1 mg kg(-1) or aminophylline 2 mg kg(-1) hastened the early recovery from sevoflurane anaesthesia. The arousal effect of aminophylline and doxapram appears to be similar.
Wu
C-C
CC
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC.
Lin
C-S
CS
Wu
G-J
GJ
Lin
Y-H
YH
Lee
Y-W
YW
Chen
J-Y
JY
Mok
M S
MS
D000328:Adult; D000628:Aminophylline / Q000627:therapeutic use*; D000704:Analysis of Variance; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D001143:Arousal / Q000187:drug effects; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D004315:Doxapram / Q000627:therapeutic use*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008738:Methyl Ethers; D016343:Monitoring, Intraoperative / Q000379:methods; D011446:Prospective Studies; D011597:Psychomotor Performance / Q000187:drug effects; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D002316:Cardiotonic Agents; D000697:Central Nervous System Stimulants; D008738:Methyl Ethers; D000628:Aminophylline; D000077149:Sevoflurane; D004315:Doxapram