Synthetic Peptide templates for molecular recognition: recent advances and applications.
The creation of molecular systems that can mimic some of the properties of natural macromolecules is one of the major endeavors in contemporary protein chemistry. However, the construction of artificial proteins with predetermined structure and function is difficult on account of complex folding pathways. The use of topological peptide templates has been suggested to induce and stabilize defined secondary and tertiary structures. This is because the recent advances in the chemistry of coupling reagents, protecting groups, and solid-phase synthesis have made the chemical synthesis of peptides with conformationally controlled and complex structures feasible. Besides their use as structure-inducing devices, these peptide templates can also be utilized to construct novel structures with tailor-made functions. Herein, we present recent advances in the field of peptide-template-based approaches with particular emphasis on the demonstrated utility of this approach in molecular recognition, along with related applications.
Singh
Yashveer
Y
LEDSS, UMR CNRS 5616, ICMG FR 2607, Universite Joseph Fourier, Grenoble Cedex 9, France.
Dolphin
Gunnar T
GT
Razkin
Jesus
J
Dumy
Pascal
P
D016229:Amyloid beta-Peptides / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry; D007473:Ion Channels / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011485:Protein Binding
D016229:Amyloid beta-Peptides; D002241:Carbohydrates; D007473:Ion Channels; D010455:Peptides