title: [Effect of compound glycyrrhizin on peripheral T-lymphocyte subset in AIDS patients].
abstract: OBJECTIVE
  To probe the effect and mechanism of Compound Glycyrrhizin in treating AIDS.
  
  
  METHODS
  Forty AIDS patients were randomly divided into a treatment group and a control group, both treated with HAART. In addition, the former was given Compound Glycyrrhizin for 6 months, and the CD4+ T count and the expressions of CD8+ and HLA-DR on the surface of peripheral blood lymphocytes (PBL) were studied before and after the treatment.
  
  
  RESULTS
  After 6 months of treatment, the expressions of CD8+ and CD38+ of PBL in the treatment group [(6.6 +/- 2.1)%] were found lower than in the control [(11.4 +/- 3.8)%] (t = 5.043, P < 0.01) and CD4+ T count [(243.6 +/- 91.2) x 10(6)/L vs (170.8 +/- 55.7) x 10(6)/L] rose more significantly (t = 3.045, P < 0.01).
  
  
  CONCLUSIONS
  Compound Glycyrrhizin can lower the expression of active T-lymphocyte subset, inhibit HIV and help immune reconstitution.
authors.affiliation: Department of Infections, the Second Hospital of Nanjing Affiliated to Southeast University Medical College, Nanjing, Jiangsu 210003, China. ywh1950@sina.com
authors.forename: Wen-hu
authors.initials: WH
authors.lastname: Yao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Yin-wei
authors.initials: YW
authors.lastname: Wu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Wei
authors.forename: Cong
authors.initials: C
authors.lastname: Cheng
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.forename: Yun
authors.initials: Y
authors.lastname: Chi
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000096:biosynthesis; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D019695:Glycyrrhizic Acid / Q000627:therapeutic use*; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents; D006684:HLA-DR Antigens; D019695:Glycyrrhizic Acid; D051997:ADP-ribosyl Cyclase 1