title: Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke.
abstract: Female Sprague-Dawley rats were exposed to mainstream smoke from standard reference cigarettes and a nontobacco cellulose cigarette for 35 days. Whole smoke and smoke fractions were investigated. Lung inflammation was evaluated by differentiation of bronchoalveolar lavage cells and lymphocytes in thoracic lymph nodes. Histopathological changes in the nose and larynx were assessed. Results showed that the particulate phase of cigarette mainstream smoke is mostly responsible for inflammation in the lung (neutrophil increase up to 240-fold) and hyperplastic and metaplastic epithelial changes in the larynx, whereas irritative volatile constituents in the gas phase are mostly responsible for changes in the nose.
authors.affiliation: Philip Morris Research Laboratories GmbH, Cologne, Germany. barbel.friedrichs@pmintl.com
authors.forename: Bärbel
authors.initials: B
authors.lastname: Friedrichs
authors.forename: Erik van
authors.initials: Ev
authors.lastname: Miert
authors.forename: Patrick
authors.initials: P
authors.lastname: Vanscheeuwijck
mesh_terms: D000818:Animals; D018893:Bronchoalveolar Lavage; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D007249:Inflammation; D007830:Larynx / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D009666:Nose / Q000473:pathology; D011014:Pneumonia / Q000276:immunology / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012906:Smoke / Q000009:adverse effects*; D015208:Smoke Inhalation Injury / Q000276:immunology / Q000503:physiopathology*; D014026:Nicotiana
chemical_list: D012906:Smoke