An Interlocker concept of carcinogenesis.
A critical feature in the sequence of events occurring during carcinogenesis is the development of irreversibility. The term "Interlocker" is used here to denote a mechanism by which irreversibility is brought about. The presentation focuses on conceptualizations of such processes. Two will be described below.
Wattenberg
Lee W
LW
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. watte002@umn.edu
D000818:Animals; D002471:Cell Transformation, Neoplastic; D003210:Concept Formation; D006801:Humans; D009369:Neoplasms / Q000473:pathology*