title: Pediatric reference intervals for uncommon bleeding and thrombotic disorders.
abstract: This study provides pediatric reference intervals and median values for factors II, V, VII, X, fibrinogen, alpha-2-antiplasmin (AP), antithrombin (AT), plasminogen, protein C (PC), and protein S (PS) for children 7 to 17 years of age. All analytes exhibited at least some age dependence in late childhood and adolescence either when compared against adult values or when medians for children were regressed against age.
authors.affiliation: ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Flanders
authors.forename: Amit R
authors.initials: AR
authors.lastname: Phansalkar
authors.forename: Ronda A
authors.initials: RA
authors.lastname: Crist
authors.forename: William L
authors.initials: WL
authors.lastname: Roberts
authors.forename: George M
authors.initials: GM
authors.lastname: Rodgers
mesh_terms: D000293:Adolescent; D000991:Antithrombins / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000378:metabolism* / Q000503:physiopathology*; D002648:Child; D005165:Factor V / Q000378:metabolism; D005167:Factor VII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D010372:Pediatrics / Q000379:methods* / Q000592:standards*; D010958:Plasminogen / Q000378:metabolism; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D012016:Reference Values; D020246:Venous Thrombosis / Q000378:metabolism* / Q000503:physiopathology*; D000979:alpha-2-Antiplasmin / Q000378:metabolism
chemical_list: D000991:Antithrombins; D011486:Protein C; D017293:Protein S; D000979:alpha-2-Antiplasmin; D005165:Factor V; D005167:Factor VII; D011516:Prothrombin; D005170:Factor X; D005340:Fibrinogen; D010958:Plasminogen