title: Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: A case study.
abstract: METHODS
  This is a case report of a 64-year-old white male with a 20 year history of unilateral hip pain that had become debilitating over the last several years. On intake, Harris hip score was rated as: Pain subscale = 10, Function subscale = 32, Deformity subscale = 4, Motions subscale = 4.775 with a total score of 50.8 out of 100. MRI of the affected hip showed severe degeneration with spurring, decrease in joint space, and several large subchondral cysts. The patient had been evaluated by an orthopedic surgeon and told he was a candidate for bipolar hip replacement.
  
  
  METHODS
  Two autologous nucleated cell collections were performed from bone marrow with subsequent isolation and transfers into the intra-articular hip using a hyaluronic acid and thrombin activated platelet rich plasma scaffold. Marrow samples were processed by centrifugation and lysis techniques to isolate nucleated cells.
  
  
  CONCLUSIONS
  This report describes partial by articular surface regeneration 8 weeks after intraarticular bone marrow transfer. Post-op 3.0T FGRE MRI showed neocortex formation when compared to immediate pre-op MRI and objective improvements were noted that coincided with subjective reports of improvement.
authors.affiliation: The Centeno-Schultz Clinic, 11080 Circle Point Road, Building 2, Suite 140, Westminster, CO 80020, USA. centenooffice@cenenoclinic.com
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Centeno
authors.forename: John
authors.initials: J
authors.lastname: Kisiday
authors.forename: Michael
authors.initials: M
authors.lastname: Freeman
authors.forename: John R
authors.initials: JR
authors.lastname: Schultz
mesh_terms: D016026:Bone Marrow Transplantation; D006621:Hip Joint / Q000473:pathology / Q000502:physiology*; D006801:Humans; D006820:Hyaluronic Acid; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000628:therapy*; D059408:Pain Management; D012038:Regeneration; D013917:Thrombin; D014182:Transplantation, Autologous
chemical_list: D006820:Hyaluronic Acid; D013917:Thrombin