title: Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae.
abstract: In a set of 190 duplicate gene pairs in yeast Saccharomyces cerevisiae, the sharing of transcription factors tended to decrease with increased divergence in coding sequence, at both synonymous and nonsynonymous sites. Our results showed a significantly higher sharing of transcription factors by duplicated gene pairs falling within duplicated genomic blocks than in other duplicated gene pairs; and genes in duplicated blocks also showed significantly greater conservation at the coding sequence level. In spite of the overall trends, there were certain gene pairs, both in duplicated blocks and in other genomic regions, which were highly divergent in coding sequence and yet had identical patterns of transcription factor binding. These results suggest that functional differentiation of genes after duplication is a multi-dimensional process, with different duplicate pairs differentiating in different ways.
authors.affiliation: Department of Biological Sciences, University of South Carolina, Coker Life Sciences Bldg. 700 Sumter St., Columbia, SC 29208, USA. austin@biol.sc.edu
authors.forename: Austin L
authors.initials: AL
authors.lastname: Hughes
authors.forename: Robert
authors.initials: R
authors.lastname: Friedman
mesh_terms: D001483:Base Sequence; D019295:Computational Biology; D019143:Evolution, Molecular; D020131:Genes, Duplicate / Q000235:genetics*; D005800:Genes, Fungal / Q000235:genetics*; D014644:Genetic Variation; D016013:Likelihood Functions; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D016415:Sequence Alignment; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D014157:Transcription Factors