title: The alterations in genetic apparatus of somatic and generative cells of the host caused by helminths metabolites.
abstract: Alterations in the genetic apparatus of mice bone marrow cells and testicles caused by Hymenolepis nana, Ascaris suum and Toxocara canis metabolites have been investigated by means of micronuclear test application. The activity of spermatogenesis has been investigated at experimental hymenolepidosis, migrating ascariasis and toxocarosis with the use of 3H-timidine. Helminths metabolites have been established to exert a mutagenic effect on somatic cells of bone marrow, spermatogonies and also on the generative cells (spermatides) of helminths in invaded mice. The concurrent increase in micronucleus number in erythrocytes, spermatogonies and in spermatides (to a lesser degree) of invaded mice has been revealed. The decrease in spermatogenesis activity has been established in experimental hymenolepidosis, migrating ascariasis and toxocarosis in invaded mice.
authors.affiliation: Vitebsk State Medical University, Vitebsk, 27 Frunze ave., Belarus.
authors.forename: V J
authors.initials: VJ
authors.lastname: Bekish
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations / Q000662:veterinary; D004249:DNA Damage; D015801:Helminth Proteins / Q000378:metabolism / Q000633:toxicity*; D006374:Helminthiasis, Animal / Q000235:genetics* / Q000469:parasitology*; D006376:Helminths / Q000378:metabolism*; D006790:Host-Parasite Interactions; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D009152:Mutagenicity Tests / Q000662:veterinary; D009153:Mutagens / Q000378:metabolism / Q000633:toxicity*; D013087:Spermatids / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*
chemical_list: D015801:Helminth Proteins; D009153:Mutagens