title: Synthetic studies toward the bryostatins: a substrate-controlled approach to the A-ring.
abstract: [reaction: see text] The synthesis of a C1-C13 A-ring subunit of bryostatin 1 is detailed. The key features of the approach include the convergent fragment assembly with a highly stereoselective construction of the C7-C8 bond indicated above.
authors.affiliation: Department of Chemistry, University of Utah, 315 South 1400 East RM 2020, Salt Lake City, Utah 84112-0850, USA. keck@chemistry.utah.edu
authors.forename: Gary E
authors.initials: GE
authors.lastname: Keck
authors.forename: Dennie S
authors.initials: DS
authors.lastname: Welch
authors.forename: Paige K
authors.initials: PK
authors.lastname: Vivian
mesh_terms: D000818:Animals; D054713:Bryostatins; D002013:Bryozoa / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D054713:Bryostatins; D018942:Macrolides; C046785:bryostatin 1