MDM2 SNP309 and SNP354 are not associated with lung cancer risk.
A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been found to be associated with tumor formation. Publication of this null report is important because an association between MDM2 SNP309 and lung cancer was previously reported in two independent studies. Our findings suggest that MDM2 SNP309 is not a strong factor in lung carcinogenesis. In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls.
Pine
Sharon R
SR
Laboratory of Human Carcinogenesis, National Cancer Institute, Room 3068, Building 37, 37 Convent Drive, Bethesda, MD 20892-4258, USA.
Mechanic
Leah E
LE
Bowman
Elise D
ED
Welsh
Judith A
JA
Chanock
Stephen C
SC
Shields
Peter G
PG
Harris
Curtis C
CC
D044383:Black People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D014481:United States; D044465:White People / Q000235:genetics; D001741:Black or African American
C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2