FOXP3 ensembles in T-cell regulation.
Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T-cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding of how FOXP3 expression is induced and how FOXP3 functions in vivo as a transcriptional regulator by assembling a multisubunit complex involved in histone modification as well as chromatin remodeling.
Li
Bin
B
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.
Samanta
Arabinda
A
Song
Xiaomin
X
Furuuchi
Keiji
K
Iacono
Kathryn T
KT
Kennedy
Sarah
S
Katsumata
Makoto
M
Saouaf
Sandra J
SJ
Greene
Mark I
MI
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000628:therapy; D042002:Chromatin Assembly and Disassembly; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D051858:Forkhead Transcription Factors / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000737:chemistry / Q000201:enzymology / Q000276:immunology*; D014158:Transcription, Genetic
D004791:Enzyme Inhibitors; D051858:Forkhead Transcription Factors; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D006655:Histone Deacetylases