title: [Comparison of inflammatory response after laparoscopic and conventional surgery for colorectal carcinoma].
abstract: OBJECTIVE
  To compare the systemic and local inflammatory response after laparoscopic and conventional surgery for colorectal carcinoma.
  
  
  METHODS
  From April 2004 to August 2004, 51 colorectal cancer patients undergoing laparoscopic (n=25) and conventional open (n=26) colorectal resection were enrolled in the study. The general clinical data,and inflammatory response were compared between the two groups.
  
  
  RESULTS
  There were no significant differences in age, sex, pre-operative levels of haemoglobin and albumin, Dukes stage and surgical procedure between the two groups (P > 0.05). Laparoscopic surgery had more advantages over conventional open surgery such as incision, operating time, recovery time of bowel function, and hospitalization. On postoperative day (POD) 1, WBC count [(7.30+/- 2.62)x10(9)/L], and the serum levels of IL-10 [(19.46+/- 3.31)pg/ml] and C-reactive protein (CRP) [(2.76+/- 2.17)mg/dl] were significantly lower in laparoscopic group than those in conventional group (P< 0.05), but there were no differences on POD 4 between the two groups (P > 0.05). There were no significant differences in the volume of peritoneal drainage fluid, and levels of IL-10, TNF and CRP in it on POD 1 between the two groups, but the volume of peritoneal drainage fluid decreased significantly from POD 2, and the level of IL-10 in it was significantly lower on POD 4 in laparoscopic group than that in conventional group.
  
  
  CONCLUSIONS
  In early stage after operation,intra- peritoneal inflammatory response caused by laparoscopic surgery is similar to that by conventional open surgery, but systemic inflammatory response is slighter than that by conventional open surgery for colorectal carcinoma.
authors.affiliation: Department of Surgery, Ruijin Hospital, Shcool of Medicine, Shanghai Jiaotong University, Shanghai Minimally Invasive Surgery Center, Shanghai Institute of Digestive Surgery, Shanghai 200025, China. zhihaimao@163.com
authors.forename: Zhi-hai
authors.initials: ZH
authors.lastname: Mao
authors.forename: Hai-zhen
authors.initials: HZ
authors.lastname: Chen
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Li
authors.forename: Ai-guo
authors.initials: AG
authors.lastname: Lu
authors.forename: Ming-liang
authors.initials: ML
authors.lastname: Wang
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Hu
authors.forename: Min-hua
authors.initials: MH
authors.lastname: Zheng
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D007249:Inflammation; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged