title: Practical beta-lactone synthesis: epoxide carbonylation at 1 atm.
abstract: [reaction: see text] A readily prepared bimetallic catalyst is capable of effecting epoxide carbonylation to produce beta-lactones at substantially lower CO pressures than previously reported catalyst systems. A functionally diverse array of beta-lactones is produced in excellent yields at CO pressures as low as 1 atm. This procedure allows for epoxide carbonylation on a multigram scale without the requirement of specialized, high-pressure equipment.
authors.affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Kramer
authors.forename: Emil B
authors.initials: EB
authors.lastname: Lobkovsky
authors.forename: Geoffrey W
authors.initials: GW
authors.lastname: Coates
mesh_terms: D002384:Catalysis; D002857:Chromium / Q000737:chemistry; D018360:Crystallography, X-Ray; D004852:Epoxy Compounds / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004852:Epoxy Compounds; D007659:Ketones; D007783:Lactones; D009942:Organometallic Compounds; D002857:Chromium