Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology.
We report a case of primary peritoneal carcinoma with trophoblastic morphology in a 78-year-old woman, diagnosed by histological and immunohistochemical analysis of surgically resected specimens, including the omentum and part of the small bowel. Microscopically, the resected specimens showed diffuse infiltration of a poorly differentiated tumor. Numerous large, often multinucleated cells were seen, and mitotic figures were frequent. Immunohistochemical staining showed a positive reaction for most cytokeratins, EP4, EMA, CA-125, Glut1, WT1, beta-hCG and PLAP. We reached a diagnosis of primary peritoneal carcinoma with trophoblastic morphology. To our knowledge this morphology of a primary peritoneal carcinoma has not been described previously.
Madsen
Charlotte Winther
CW
Department of Pathology, Naestved Hospital, Denmark.
Hasselby
Jane Preuss
JP
Larsen
Lise Grupe
LG
D000368:Aged; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D006801:Humans; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary*; D014328:Trophoblastic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology*