title: A multimodal perioperative plan for radical cystectomy and urinary intestinal diversion: effects, limits and complications of early artificial nutrition.
abstract: OBJECTIVE
  We evaluated the effects of early parenteral and enteral postoperative nutritional support on the restoration of normal bowel function, on the protein depletion that follows cystectomy and on observed complications.
  
  
  METHODS
  Immediate parenteral nutrition was initiated after surgery. It was progressively shifted to the enteral route through a needle catheter jejunostomy inserted at surgery.
  
  
  RESULTS
  A total of 28 patients with a mean age of 74.2 years (range 55 to 82) were enrolled into the study. Disease was pathologically confined to the bladder in 22 patients, locally advanced in 3 and extravesical in 3. Urinary diversions included an ileocolonic pouch in 15 patients and an orthotopic ileal reservoir in 13. Of the 28 patients 15 (53.6%) completed the protocol, whereas 13 (46.4%) did not. Median time to peristalsis and spontaneous passage of flatus was postoperative day 2 (range 2 to 5) and median time to normal diet resumption was postoperative day 4 (range 3 to 8). No significant differences were observed between patients who completed the protocol and those who did not with regard to the restoration of normal bowel function, and total protein, serum albumin and lymphocyte count. Minor complications were observed in 9 patients and major complications developed in 4.
  
  
  CONCLUSIONS
  Early postoperative artificial nutrition did not affect the return of bowel function or postoperative protein depletion. Different strategies for more effective nutritional support will be explored in further studies.
authors.affiliation: Strutturas Complessa di Urologia, E. O. Ospedali Galliera, Mura Delle Cappuccine 14, 16128 Genoa, Italy. massimo.maffezzini@galliera.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Maffezzini
authors.forename: Guido
authors.initials: G
authors.lastname: Gerbi
authors.forename: Fabio
authors.initials: F
authors.lastname: Campodonico
authors.forename: Donatella
authors.initials: D
authors.lastname: Parodi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy / Q000379:methods*; D005260:Female; D006801:Humans; D007582:Jejunostomy; D008297:Male; D008875:Middle Aged; D018529:Nutritional Support / Q000009:adverse effects*; D011182:Postoperative Care / Q000379:methods; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D014547:Urinary Diversion / Q000379:methods*