Use of proton pump inhibitors during pregnancy and breastfeeding.
OBJECTIVE
A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy.


CONCLUSIONS
Data currently available suggest that omeprazole is not teratogenic in humans. While information on other PPIs is limited, a systematic review of the evidence suggests that they are also not teratogenic.
Nava-Ocampo
Alejandro A
AA
Hospital for Sick Children in Torinto, Ont.
Velázquez-Armenta
Elvia Y
EY
Han
Jung-Yeol
JY
Koren
Gideon
G
D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001942:Breast Feeding; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D054328:Proton Pump Inhibitors
D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors