Effects of ulinastatin on postoperative systemic inflammatory response of recipients of rat small bowel transplantation.
OBJECTIVE
We sought to evaluate the effects of ulinastatin on postoperative systemic inflammatory responses of recipients of rat small bowel transplantations (SBT).


METHODS
Twenty-four recipients of rat heterotopic SBT were randomly divided into a control group and a treated group. Ulinastatin (50,000 U/kg(-1)/d(-1)) was injected intravenously 30 minutes before graft revascularization. Measured variables included plasma concentrations of tumor necrosis factor (TNF), interleukin (IL)-6, and C-reactive protein (CRP) on postoperative days 1 and 3.


RESULTS
Administration of ulinastatin attenuated the postoperative increases in plasma concentrations of TNF, IL-6, and CRP.


CONCLUSIONS
Ulinastatin attenuated the postoperative systemic inflammatory response of rat recipients of SBT.
Sun
J-L
JL
Department of Operation, Qilu Hospital of Shandong University, Shandong, China.
Zhang
X-Q
XQ
Yu
Z-G
ZG
Ma
R
R
Dai
Y
Y
Fan
Z-Y
ZY
Sun
J-Z
JZ
D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D006023:Glycoproteins / Q000494:pharmacology*; D007249:Inflammation / Q000503:physiopathology*; D015850:Interleukin-6 / Q000097:blood; D007421:Intestine, Small / Q000637:transplantation*; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D014185:Transplantation, Isogeneic / Q000502:physiology; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015415:Biomarkers; D006023:Glycoproteins; D015850:Interleukin-6; D014361:Trypsin Inhibitors; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; C028665:urinastatin