title: Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis.
abstract: New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their structures were established by various spectroscopic analyses. Compounds 1 and 3 were proposed to be biosynthesized from the oxidative coupling of the precursor hispidin with 3,4-dihydroxybenzaldehyde and 3,4-dihydroxybenzoic acid, respectively. These compounds exhibited significant scavenging activity against the ABTS radical cation, and compounds 2 and 4 displayed moderate superoxide radical scavenging activity.
authors.affiliation: Functional Metabolomics Research Center, KRIBB, Yuseong, Daejeon 305-333, Republic of Korea.
authors.forename: In-Kyoung
authors.initials: IK
authors.lastname: Lee
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Jung
authors.forename: Soon-Ja
authors.initials: SJ
authors.lastname: Seok
authors.forename: Wan-Gyu
authors.initials: WG
authors.lastname: Kim
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
mesh_terms: D000363:Agaricales / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000378:metabolism*; D011753:Pyrones / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D016166:Free Radical Scavengers; D011753:Pyrones