title: Left bundle branch block as a risk factor for progression to heart failure.
abstract: The prevalence of conduction disturbances, particularly left bundle branch block (LBBB), is strongly correlated with age and with the presence of cardiovascular disease. LBBB has been reported to affect approximately 25% of the heart failure (HF) population and it is likely that the deleterious role of such conduction disorders in the progression to HF has been underestimated. The purpose of this article is to review the data from the literature indicating that LBBB may have a causative role, mediated through the resulting intra-ventricular asynchrony, in the deterioration of cardiac function and the development of cardiac remodelling and HF. It also aims to address the potential for future clinical therapies for this conduction disorder.
authors.affiliation: CIC-INSERM-CHU de Nancy, Hôpital Jeanne d'Arc, Dommartin-lès-Toul, BP 303 - 54201 Toul Cedex, France. f.zannad@chu-nancy.fr
authors.forename: Faiez
authors.initials: F
authors.lastname: Zannad
authors.forename: Etienne
authors.initials: E
authors.lastname: Huvelle
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dickstein
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: van Veldhuisen
authors.forename: Christoph
authors.initials: C
authors.lastname: Stellbrink
authors.forename: Lars
authors.initials: L
authors.lastname: Køber
authors.forename: Serge
authors.initials: S
authors.lastname: Cazeau
authors.forename: Philippe
authors.initials: P
authors.lastname: Ritter
authors.forename: Aldo Pietro
authors.initials: AP
authors.lastname: Maggioni
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
authors.forename: Philippe
authors.initials: P
authors.lastname: Lechat
mesh_terms: D002037:Bundle-Branch Block / Q000150:complications / Q000503:physiopathology*; D018450:Disease Progression; D007839:Functional Laterality; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology