title: Low levels of B-type natriuretic peptide predict poor clinical outcomes in patients with chronic and advanced heart failure.
abstract: B-type natriuretic peptide (BNP) is a neurohormone produced mainly by ventricular myocytes in response to increased left ventricular end-diastolic pressure. Patients with acute decompensated heart failure often have elevated plasma BNP. However, recent clinical observations have demonstrated that in patients with advanced heart failure, the plasma level of BNP is lower than those with acute heart failure. We hypothesized that a lower circulating BNP level in patients with chronic and advanced heart failure is due to the exhaustion of the biosynthesis mechanisms and is associated with a poor outcome in these patients.
authors.affiliation: Emergency Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, PR China.
authors.forename: Tong-wen
authors.initials: TW
authors.lastname: Sun
authors.forename: Le-xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D015415:Biomarkers / Q000097:blood; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D013534:Survival; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain