The clinical significance of serum and urinary neopterin levels in several renal diseases.
Neopterin is a pyrazino-pyrimidine compound, and is known to be a marker associated with cell-mediated immunity in various diseases. We hypothesized that the levels of serum and urine neopterin would be elevated in renal disease, and would correlate with certain clinical parameters. We evaluated serum and urinary neopterin levels in patients with several renal diseases, including nephrotic syndrome (NS, n=19), chronic renal failure (CRF, n=8), end stage renal disease (ESRD, n=64) and controls (n=22). Serum neopterin was elevated in patients with CRF and ESRD, as compared to controls. Urinary neopterin levels were also found to be elevated in patients with CRF and ESRD, as compared to controls. Serum neopterin levels showed significant positive correlation with age, serum BUN and creatinine levels, and inverse correlation with WBC, hemoglobin, hematocrit, serum albumin and total iron binding capacity. Urine neopterin levels exhibited positive correlation with age and serum creatinine levels, and inverse correlation with WBC, hemoglobin, hematocrit, BUN and serum albumin. In conclusion, increased serum and urinary neopterin levels were found in some patients with renal disease and were correlated with certain clinical parameters.
Lhee
Hyun Young
HY
Department of Internal Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Jongro-gu, Seoul, Korea.
Kim
Hyang
H
Joo
Kwan Joong
KJ
Jung
Soo Suk
SS
Lee
Kyu Beck
KB
D000328:Adult; D000367:Age Factors; D000368:Aged; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000473:pathology* / Q000652:urine; D007676:Kidney Failure, Chronic / Q000097:blood / Q000473:pathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood* / Q000652:urine*; D009404:Nephrotic Syndrome / Q000097:blood / Q000473:pathology / Q000652:urine; D011863:Radioimmunoassay / Q000379:methods; D014280:Triglycerides / Q000097:blood
D006454:Hemoglobins; D014280:Triglycerides; D019798:Neopterin; D003404:Creatinine