title: Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase.
abstract: Aldose reductase, the first key enzyme in the polyol pathway, is involved in complications of diabetes. Sclerotiorin, isolated and purified from the fermented broth of Penicillium frequentans, inhibited aldose reductase with an IC(50 )0.4 microM. The inhibitor also showed antibacterial activity against Bacillus spp.
authors.affiliation: Fermentation Technology and Bioengineering Department, Central Food Technological Research Institute, Mysore, 570020, India.
authors.forename: C
authors.initials: C
authors.lastname: Chidananda
authors.forename: L Jagan Mohan
authors.initials: LJ
authors.lastname: Rao
authors.forename: A P
authors.initials: AP
authors.lastname: Sattur
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D001578:Benzopyrans / Q000494:pharmacology*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology; D010407:Penicillium / Q000737:chemistry*; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; C101449:sclerotiorin; D000449:Aldehyde Reductase