Role of cyclosporin in preventing or delaying colectomy in children with severe ulcerative colitis.
BACKGROUND
Oral cyclosporin (CyA) has been widely and successfully used in adult patients with severe ulcerative colitis (UC) to delay or avoid colectomy.


OBJECTIVE
To determine if treatment with oral CyA is similarly effective in pediatric patients


METHODS
Data on all patients with severe UC treated with oral CyA in our unit were collected retrospectively. Patients were treated with CyA if dependent on or resistant to steroids, and therefore, candidates for colectomy.


RESULTS
Thirty-two patients with severe UC were treated with CyA administered orally at a dose needed to obtain therapeutic blood levels (150-250 ng/ml). Twenty-eight of 32 patients (87%) had an immediate response within 11 days. Four (13%) did not respond and underwent colectomy. One patient had two cycles of treatment and is in remission. Two patients underwent three cycles of treatment because of relapse, but both eventually underwent elective colectomy. Three other patients underwent elective colectomy. A total of nine colectomies were performed.


CONCLUSIONS
Treatment with oral CyA altered the course of UC in 28/32 (87%) of patients; 4/32 (13%) did not respond to oral CyA and underwent colectomy. Of the 28 patients that responded to CyA, five underwent later elective colectomy. Overall, in 72% of patients, colectomy was avoided. We, therefore, suggest a trial of oral CyA in all children with severe UC who are dependent or resistant to corticosteroids.
Castro
M
M
Gastroenterology Unit, Ospedale Bambino Gesù, Rome, Italy.
Papadatou
B
B
Ceriati
E
E
Knafelz
D
D
De Angelis
P
P
Ferretti
F
F
Gambarara
M
M
Diamanti
A
A
De Peppo
F
F
Rivosecchi
M
M
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000601:surgery; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D012074:Remission Induction; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine