title: Somatic DNA recombination in the brain.
abstract: Possible somatic DNA recombination in the brain has been investigated by attempting to capture direct or indirect evidence of it. Until recently, the biological significance of the DNA event, the genes is involved in the recombination, or even whether the event actually occurs in the brain has remained unclear. The DNA-rearranged locus-oriented approach and the recombination activity-oriented approach have mutually contributed to the elucidation of the biological features of extra-immune system somatic DNA recombination. There have been only 2 loci proposed for the candidate, one is a repetitive sequence and the other DNA recombination is nonrepetitive locus. This review states conventional concepts and discussions chronologically and finally to the newest aspects of DNA rearrangement in the brain.
authors.affiliation: Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, Japan. maedat@beppu.kyushu-u.ac.jp
authors.forename: Toyoki
authors.initials: T
authors.lastname: Maeda
authors.forename: Saburo
authors.initials: S
authors.lastname: Sakoda
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Naoki
authors.initials: N
authors.lastname: Makino
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D015321:Gene Rearrangement; D006801:Humans; D011995:Recombination, Genetic