[Effect of the genetic factor and nociceptive stimule on the development of visceral pain].
The experimental research of painful behavioural reaction on nociceptive visceral stimulus with outinbred white and of the C57BL/6J and CBA/ CaLac genetic strains of mice was carried out. Influence of intraperitoneal administration of the different volumes and concentration of acetic acid solution on visceral painful behavioural reaction at these animals was shown. It was found that CBA/ CaLac had a higher intensity of visceral painful behavioural reaction (on 32 %), than C57BL/6J strain. Comparison of intensity of behavioural reactions to a somatic pain in these animals (the formalin test) has shown that at CBA/CaLac this intensity was lower by 48.5 % than in C57BL/6J strain. Such distinctions in the character of behavioural reactions on somatic and visceral pain may be caused by features of the functional organization of the brain central structures participating in the formation of visceral and somatic reflexes at these two genetic strains.
Sushko
B S
BS
D019342:Acetic Acid / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010146:Pain / Q000139:chemically induced / Q000235:genetics* / Q000503:physiopathology; D010147:Pain Measurement; D017288:Pain Threshold; D013045:Species Specificity; D014781:Viscera / Q000187:drug effects
D019342:Acetic Acid