title: Problems and solutions in the genetic analysis of late-onset Alzheimer's disease.
abstract: The identification of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease was a spectacularly successful application of genetic analysis to a complex trait, and it led to the hope and expectation that other risk loci for the disease would soon be forthcoming. Twelve years later, despite a huge amount of work, no other loci have been identified. In this article, we discuss the complexity of the problem and the pitfalls in the analytical methods that have been used and how we are approaching this problem.
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707, USA. hardyj@mail.nih.gov
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Amanda
authors.initials: A
authors.lastname: Myers
authors.forename: Fabienne
authors.initials: F
authors.lastname: Wavrant-De Vrieze
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans