title: Double cancer of gall bladder and bile duct not associated with anomalous junction of the pancreaticobiliary duct system.
abstract: BACKGROUND
  Simultaneous double cancers of the biliary tract are rare. Most of them are thought to be associated with pancreaticobiliary maljunction (PBM); however, the characteristics of tumours without PBM are still unclear.
  
  
  METHODS
  Histology, immunoreactivity with carcinoembryonic antigen, carbohydrate antigen 19-9 and p53 and mutations in the K-ras gene were examined in tumours resected from cases of simultaneous double cancers of the biliary tract.
  
  
  RESULTS
  Four cases of simultaneous double cancers of the biliary tract were identified among 108 patients with biliary tract cancer (3.7%). None of the four cases associated with PBM, and the results of histological, immunohistochemical and genetic examinations differed between the bile duct and gall bladder cancers in each case.
  
  
  CONCLUSIONS
  Even when they do not associate with PBM, double cancers in the biliary tract are more likely to be the result of multicentric development.
authors.affiliation: Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Kobe, Japan.
authors.forename: Hiiroshige
authors.initials: H
authors.lastname: Hori
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ajiki
authors.forename: Tsunenori
authors.initials: T
authors.lastname: Fujita
authors.forename: Taro
authors.initials: T
authors.lastname: Okazaki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimori
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D001652:Bile Ducts / Q000473:pathology; D001659:Biliary Tract / Q000473:pathology; D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D011905:Genes, ras; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009378:Neoplasms, Multiple Primary; D010183:Pancreatic Ducts / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D016159:Tumor Suppressor Protein p53