[Interferon system in children with cystic fibrosis].
Parameters of interferon-producing leukocyte function were studied in vitro, in 32 patients of different age (from 1 month to 14 years) with cystic fibrosis and 30 normal children. Mixed form of cystic fibrosis were detected in 20 patients, while bronchopulmonary form were found in 12 patients. According to Shvaxman scale 16 patients had 40 point (severe), 13 patient had 41-45 point (moderate) and 3 patient had 56-70 point (mild). The interferon was studied using the Soloviov-Bektemirov technique in the A. Natishvili Institute of Experimental Morphology of Georgian Academy of Sciences. Interferon level varied between 0 and 2 U/ml both during the acute phase and remission, while the normal level would be at 4-24 U/ml. Therefore, interferon therapy can be recommended as part of combined treatment, particularly at an early stage of acute respiratory viral infection, during epidemic outbreaks and in hospital where patient should only be admitted (and kept in individual cubicles) after outpatient treatment for aggravations of the disease proved ineffective.
Badriashvili
N R
NR
Topuridze
N L
NL
Chakhunashvili
G S
GS
Tabutsadze
D O
DO
Khvtisiashvili
N O
NO
D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007372:Interferons / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism; D011379:Prognosis; D012720:Severity of Illness Index
D015415:Biomarkers; D007372:Interferons