The mycobacterium-specific gene Rv2719c is DNA damage inducible independently of RecA.
The mycobacterium-specific gene Rv2719c was found to be expressed primarily from a promoter that was clearly DNA damage inducible independently of RecA. Upstream of the transcriptional start site for this promoter, sequence motifs resembling those observed previously at the RecA-independent, DNA damage-inducible recA promoter were identified, and the -10 motif was demonstrated by mutational analysis in transcriptional fusion constructs to be important for expression of Rv2719c.
Brooks
Patricia C
PC
Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, United Kingdom.
Dawson
Lisa F
LF
Rand
Lucinda
L
Davis
Elaine O
EO
D001483:Base Sequence; D004249:DNA Damage / Q000502:physiology*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D011938:Rec A Recombinases / Q000378:metabolism*; D024363:Transcription Initiation Site
D004269:DNA, Bacterial; D011938:Rec A Recombinases