title: Hydrogen plasma surface activation of silicon for biomedical applications.
abstract: Silicon has gradually been recognized to be an essential trace element in the normal metabolism of higher animals, and the role of silicon in the human body has aroused interests in the biomedical community. In fact, the interactions between silicon-based devices and the human body such as biosensors and microelectromechanical systems (MEMS) often suffer from poor biocompatibility. In this work, hydrogen plasma immersion ion implantation (H-PIII) is conducted to improve the bioactivity or bone conductivity of silicon. In order to investigate the formation mechanism of bone-like apatite on the surface of the hydrogen implanted silicon wafer, two comparative experiments, hydrogenation and argon bombardment, are performed. The H-PIII sample exhibits an amorphous surface consisting of Si-H bonds. After immersion in simulated body fluids, a negatively charged surface containing the functional group ([triple bond]Si-O-) is produced and bone-like apatite is observed to nucleate and grow on the surface. The surface of the H-PIII silicon wafer favors the adhesion and growth of osteoblast cells and good cytocompatibility may be inferred.
authors.affiliation: Department of Physics & Materials Science, City University of Hong Kong, Kowloon, Hong Kong, China. xyliu@mail.sic.ac.cn
authors.forename: Xuanyong
authors.initials: X
authors.lastname: Liu
authors.forename: Ricky K Y
authors.initials: RK
authors.lastname: Fu
authors.forename: Chuanxian
authors.initials: C
authors.lastname: Ding
authors.forename: Paul K
authors.initials: PK
authors.lastname: Chu
mesh_terms: D001698:Biomedical Engineering / Q000379:methods; D001826:Body Fluids / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D017886:Durapatite / Q000737:chemistry*; D006358:Hot Temperature; D006801:Humans; D006859:Hydrogen / Q000737:chemistry*; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D012825:Silicon / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D006859:Hydrogen; D017886:Durapatite; D012825:Silicon