Scleromyxedema, a positive effect with thalidomide.
Scleromyxedema is a rare dermatological disorder marked by widespread symmetric 2- to 3-mm, firm, waxy, closely spaced papules involving the hands, forearms, face, neck, upper trunk and thighs. The most common extracutaneous manifestation of scleromyxedema is a benign plasma cell dyscrasia. Treatment of scleromyxedema is limited by the lack of long-term results, toxicity and significant adverse side effects. We report a severe case of scleromyxedema who had marked improvement when treated with thalidomide.
Jacob
Sharon E
SE
Department of Dermatology and Cutaneous Surgery and Florida University of Miami, 33136, USA. sjacob@med.Miami.edu
Fien
Sari
S
Kerdel
Francisco A
FA
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010266:Paraproteins / Q000187:drug effects / Q000378:metabolism; D053718:Scleromyxedema / Q000097:blood / Q000188:drug therapy*; D012720:Severity of Illness Index; D013792:Thalidomide / Q000627:therapeutic use*
D020533:Angiogenesis Inhibitors; D010266:Paraproteins; D013792:Thalidomide