title: Selective radiosensitization by nitric oxide in tumor cell lines.
abstract: The radiosensitizing effect of nitric oxide (NO) on mouse and human tumor cells with different degrees of malignancy was evaluated. Cells pre-treated with the NO donor diethylenetriamine-NO (DETA-NO), were irradiated with gamma rays. Survival curves were obtained by clonogenicity and fitted to the linear-quadratic model. Results demonstrated an association between radiosensitization and degree of malignancy. The more malignant the cell line, the higher the degree of radiosensitization by DETA-NO. In conclusion, the differential radiosensitizing effect of DETA-NO shown here is of great interest for the potential use of NO in radiotherapy, due to an enhanced radiation effect on tumor vs. normal tissue.
authors.affiliation: Departamento de Radiobiología, Comisión Nacional de Energía Atómica, Av. Gral. Paz 1499, B1650KNA San Martín, Provincia de Buenos Aires, Argentina.
authors.forename: Lucía
authors.initials: L
authors.lastname: Policastro
authors.forename: Hebe
authors.initials: H
authors.lastname: Duran
authors.forename: Yann
authors.initials: Y
authors.lastname: Henry
authors.forename: Beatriz
authors.initials: B
authors.lastname: Molinari
authors.forename: Vincent
authors.initials: V
authors.lastname: Favaudon
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects* / Q000528:radiation effects*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D014226:Triazenes / Q000494:pharmacology*
chemical_list: C105351:1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene; D020030:Nitric Oxide Donors; D014226:Triazenes; D009569:Nitric Oxide