title: [Fibrinolytic and fibrinogenolytic effects of acyl urokinase and urokinase combinations in vitro].
abstract: The in vitro thrombolytic and side effects of double-strand urokinase-type plasminogen activator (tcu-PA), p-guanidinobenzoyl tcu-PA (GB-tcu-PA), and their combinations were compared. The reversible blocking of the active site stabilizes GB-tcu-PA in human plasma and results in longer thrombolysis and lesser side effects than those of tcu-PA. However, the acylated activator displays a marked lag period of thrombolytic action. GB-tcu-PA and tcu-PA combinations (molar ratios 4 : 1 and 1 : 1) induce a prolonged and effective thrombolysis without the initial lag period at a low level of plasminogen, fibrinogen, and alpha2-antiplasmin depletion in the plasma surrounding the clot.
authors.forename: L I
authors.initials: LI
authors.lastname: Mukhametova
authors.forename: R B
authors.initials: RB
authors.lastname: Aĭsina
authors.forename: S D
authors.initials: SD
authors.lastname: Varfolomeev
mesh_terms: D004795:Enzyme Stability; D005337:Fibrin / Q000032:analysis / Q000187:drug effects*; D005342:Fibrinolysis; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D010949:Plasma; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
chemical_list: D005343:Fibrinolytic Agents; D006146:Guanidines; D005337:Fibrin; D014568:Urokinase-Type Plasminogen Activator