title: [Oral treatment of vitamin B12 deficiency in subacute combined degeneration].
abstract: Vitamin B12 deficiency due to malnutrition or malabsorption may lead to pernicious anemia and neurological disorders. Although randomized prospective studies have shown that pernicious anemia can be safely treated with oral vitamin B12 even in the absence of intrinsic factor, it is still common practice to treat patients with neurological symptoms with intramuscular cyancobalamin injections. We report the successful oral treatment of subacute combined degeneration of the spinal cord in a 24-year-old woman closely monitored clinically with MRI and plasma levels of vitamin B12, homocysteine, and methylmalonic acid. We suggest monitored oral substitution therapy as first-line therapy for neurological disorders related to vitamin B12 deficiency.
authors.affiliation: Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn. j.wellmer@gmx.de
authors.forename: J
authors.initials: J
authors.lastname: Wellmer
authors.forename: K-U
authors.initials: KU
authors.lastname: Sturm
authors.forename: W
authors.initials: W
authors.lastname: Herrmann
authors.forename: J
authors.initials: J
authors.lastname: Hoever
authors.forename: T
authors.initials: T
authors.lastname: Klockgether
authors.forename: M
authors.initials: M
authors.lastname: Linnebank
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000752:Anemia, Pernicious / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D006710:Homocysteine / Q000008:administration & dosage; D006801:Humans; D007437:Intrinsic Factor / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008764:Methylmalonic Acid / Q000008:administration & dosage; D009460:Neurologic Examination / Q000187:drug effects; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D014805:Vitamin B 12 / Q000008:administration & dosage*; D014806:Vitamin B 12 Deficiency / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D006710:Homocysteine; D008764:Methylmalonic Acid; D007437:Intrinsic Factor; D005492:Folic Acid; D014805:Vitamin B 12