Synthesis and properties of cordycepin intercalates of Mg-Al-nitrate layered double hydroxides.
Layered double hydroxides (LDHs) were investigated as cordycepin delivery nanocarriers for the first time in this study. Negatively charged biomolecule-cordycepin was intercalated in the gallery spaces of [Mg-Al-NO(3)] as the charge-compensating species, which was confirmed by the results of XRD, FT-IR, TEM, CZE and electrophoretic mobility. Cell experiment suggested that the new bio-LDH nanohybrid could prevent cordycepin decomposition by adenosine deaminase. This new formulation could possibly be used as a novel form cordycepin intravenous injection.
Yang
Qin Zheng
QZ
School of Food and Bioengineering, Shandong Institute of Light Industry, Jinan 250100, PR China. yangqinzheng@sina.com
Yang
Jing
J
Zhang
Chang Kai
CK
D000243:Adenosine Deaminase / Q000737:chemistry; D017607:Aluminum Compounds / Q000737:chemistry*; D000536:Aluminum Hydroxide / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003839:Deoxyadenosines / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006878:Hydroxides / Q000737:chemistry*; D007770:L-Lactate Dehydrogenase / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D008276:Magnesium Hydroxide / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D009566:Nitrates / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D020298:U937 Cells
D017607:Aluminum Compounds; D003839:Deoxyadenosines; D006878:Hydroxides; D009566:Nitrates; D000536:Aluminum Hydroxide; D007770:L-Lactate Dehydrogenase; D000243:Adenosine Deaminase; C058120:cordycepin; C050609:aluminum nitrate; D008274:Magnesium; D008276:Magnesium Hydroxide