G-quartet formation from an N2-modified guanosine derivative.
[structure: see text] We report G-quartet formation from an N2-modified lipophilic guanosine nucleoside, N2-(4-n-butylphenyl)-2',3',5'-O-triacetylguanosine. We show that, in the presence of either K+ or Na+, this guanosine derivative self-assembles into a D4-symmetric octamer consisting of two stacking all-syn G-quartets in a tail-to-tail (or head-to-head) fashion and a central ion.
Liu
Xiangyang
X
Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6.
Kwan
Irene C M
IC
Wang
Suning
S
Wu
Gang
G
D018360:Crystallography, X-Ray; D006151:Guanosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure
C520048:N2-(4-n-butylphenyl)-2',3',5'-O-triacetylguanosine; D006151:Guanosine