title: Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias.
abstract: OBJECTIVE
  To describe recent studies on Krüppel-like factor transcription factors and their relationship with gastrointestinal neoplasias, in particular pancreatic cancer.
  
  
  RESULTS
  Krüppel-like factor proteins are a subfamily of transcription factors characterized by the presence of a conserved DNA-binding domain comprising three Krüppel-like zinc fingers. Each distinct family member differs in its ability to regulate transcription, and, as a consequence, to influence cellular processes including cell growth and differentiation. Recently, a number of publications have provided evidence of the implication of Krüppel-like factor proteins in gastrointestinal carcinogenesis.
  
  
  CONCLUSIONS
  This article will focus on the results of studies in the field published in the last year.
authors.affiliation: Gastroenterology Research Unit, Saint Mary's Hospital, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Navtej S
authors.initials: NS
authors.lastname: Buttar
authors.forename: Martin E
authors.initials: ME
authors.lastname: Fernandez-Zapico
authors.forename: Raul
authors.initials: R
authors.lastname: Urrutia
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D051741:Kruppel-Like Transcription Factors