[Lecithin-cholesterol acyltransferase gene 608C/T polymorphism associated with atherosclerotic cerebral infarction].
OBJECTIVE
To explore the distribution of lecithin-cholesterol acyltransferase gene (LCAT) 608C/T polymorphism in Chinese Han population and the relationship of the polymorphism association with the occurrence of atherosclerotic cerebral infarction.


METHODS
The lecithin:cholesterol acyltransferase gene 608C/T polymorphism is identified by polymerase chain reaction (PCR), single-strand conformation polymorphism (SSCP)and restriction fragment length polymorphism (RFLP) in 150 patients with ACI and 122 healthy controls matching age and sex.


RESULTS
The distribution of LCAT 608C/T gene polymorphism was in accordance with Hardy-Weinberg equilibrium. The CT genotype frequency (14.0%) and T allele frequency (7.0%) in ACI group were significantly higher than those in control group (P<0.05). The concentration of high density lipoprotein cholesterol (HDL-C) in 608CC subgroups were significantly higher than those in 608CT subgroups both in ACI group and in control group (P<0.05).


CONCLUSIONS
The LCAT 608C/T polymorphism is possibly a predisposing factor in ACI happening of Chinese Han population. T allele frequency is possibly concerned with the metabolism of HDL-C.
Zhu
Xiao-yan
XY
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China. zxysdjm@yahoo.com.cn
Xu
Hong-wei
HW
Hou
Rong-yao
RY
Liu
Heng-fang
HF
Xiao
Bo
B
Yang
Xiao-su
XS
Yang
Qi-dong
QD
Tang
Bei-sha
BS
D000368:Aged; D000483:Alleles; D002544:Cerebral Infarction / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational / Q000235:genetics
D007862:Phosphatidylcholine-Sterol O-Acyltransferase