Phosphoinositide signaling plays a key role in cytokinesis.
To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.
Janetopoulos
Chris
C
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
Devreotes
Peter
P
D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D048430:Cell Shape / Q000502:physiology; D048749:Cytokinesis / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C060974:phosphatidylinositol 3,4,5-triphosphate