Stereoselective synthesis of highly O-functionalized enantiopure 2,3,4-trisubstituted tetrahydrofurans by tandem debenzylative cyclization of glycal derived 2,3-epoxy alcohols.
A new and highly efficient methodology for the construction of synthetically important highly O-functionalized enantiopure 2,3,4-trisubstituted tetrahydrofurans with three contiguous stereocenters is reported.
Reddy
L Vijaya Raghava
LV
Division of Medicinal and Process Chemistry, Central Drug Research Institute (CDRI), Lucknow 226001, India.
Roy
Abhijeet Deb
AD
Roy
Raja
R
Shaw
Arun K
AK
D000438:Alcohols / Q000737:chemistry*; D003500:Cyclization; D004852:Epoxy Compounds / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000438:Alcohols; D004852:Epoxy Compounds; D005663:Furans