Unbalanced chromosomal translocation: a cause of recurrent spontaneous abortion.
Recurrent spontaneous abortion, defined as three consecutive abortions, occurs in approximately 1% to 2% of couples. Although the cause is unknown in up to 50% of cases, about 5% of these couples are found to be a balanced translocation carrier. We report a case in which the mother was identified to be a translocation carrier following the birth of a baby with multiple congenital abnormalities.
Zarina
A L
AL
Department of Paediatrics, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur.
Jamil
M A
MA
Ng
S P
SP
Rohana
J
J
Yong
S C
SC
Salwati
S
S
Boo
N Y
NY
D000022:Abortion, Spontaneous / Q000209:etiology* / Q000235:genetics; D002879:Chromosomes, Human, Pair 10; D002884:Chromosomes, Human, Pair 15; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009006:Monosomy / Q000175:diagnosis / Q000235:genetics*; D011247:Pregnancy; D012008:Recurrence; D014178:Translocation, Genetic; D014314:Trisomy / Q000175:diagnosis / Q000235:genetics*