title: [The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion].
abstract: OBJECTIVE
  To study the relationship between otitis media of effusion (OME) and allergy by investigating eosinophil cationic protein in middle ear effusion ( MECP), middle ear effusion IgE (MIgE) and serum eosinophil cationic protein (SECP).
  
  
  METHODS
  The specimens drawn from 31 patients of OME were tested with Uni-CAP-100 allergic antigen testing system for the MECP, IgE and SECP. The results then were analyzed by statistical methods.
  
  
  RESULTS
  MECP were found in all the effusion specimens of 31 patients, the average concentration of which was 56.88 microg/L. The MECP concentration level in nine specimens (28.1%) was significantly elevated. The average concentration of MIgE was 27.2 ku/L. The MIgE concentration level in three specimens (9.7%) was remarkably increased. There was a positive correlation between the MECP level and the MIgE level( P <0.05). The average concentration of SECP was 5.6 microg/L.
  
  
  CONCLUSIONS
  ECP exists in the middle ear effusion of OME. OME is an allergic inflammatory process more localized in middle ear itself in some patients. There may be a complicated allergic mechanism in OME.
authors.affiliation: Department of Otolaryngology, the First Hospital of Hebei Medical University, Shijiazhuang, 050031, China. tianjunhai200@sina.com
authors.forename: Junhai
authors.initials: J
authors.lastname: Tian
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Liu
authors.forename: Changchun
authors.initials: C
authors.lastname: Sun
authors.forename: Haitao
authors.initials: H
authors.lastname: Xue
authors.forename: Wenxia
authors.initials: W
authors.lastname: Meng
authors.forename: Huixin
authors.initials: H
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004432:Ear, Middle / Q000378:metabolism; D047091:Eosinophil Granule Proteins / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000378:metabolism*; D055815:Young Adult
chemical_list: D047091:Eosinophil Granule Proteins; D007073:Immunoglobulin E