title: [Indexes of a functional condition of a liver with hemolytic disease of the newborn stipulated incompatibility between the mother and fetus].
abstract: The hemolytic disease of the newborn, originating as a result of sensitization of the mother to the Rh-antigen of erythrocytes of the fetus (Rh-HDN) is one of the most important causes of the loss of a fetus and newborn. One of the pathogenetic mechanisms of Rh-HDN is the hyperbilirubinemia at the expense of the toxiferous fraction of a bilirubin negatively influencing many organs of the child, including the liver. The purpose of the work was the complex study of indexes of a functional condition of a liver newborn with a various degree of gravity Rh-HDN and definition of effectiveness of the conducted therapy. The direct association between severity of illness and indexes of pigmental, excretion and detoxication of the function of the liver in newborns with Rh-HDN has been found. There were found significant relations of ALT/AP, AST/AP, GT/AP, albumin and globulin factors with the degree of cholestasis and toxic damage of the liver. The lack of normalization of indexes of the peptide uptake and the excretion function of the liver on the background of treatment indicate to the necessity of further monitoring of functional condition of the liver and realization of the correction of therapy after discharge of children from the hospital, especially with the serious form of Rh- HDN.
authors.forename: N A
authors.initials: NA
authors.lastname: Khatiashvili
mesh_terms: D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D004899:Erythroblastosis, Fetal / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000503:physiopathology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000503:physiopathology*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D001798:Blood Proteins