Synthesis of 2'-amino-LNA purine nucleosides.
The first reported synthesis of 2'-amino-LNA purine nucleosides via a transnucleosidation is accomplished enabling the preparation of oligonucleotides incorporating 2'-amino-LNA with all four natural bases.
Ravn
Jacob
J
Santaris Pharma A/S, Hørsholm, Denmark. jra@santaris.com
Rosenbohm
Christoph
C
Christensen
Signe M
SM
Koch
Troels
T
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011684:Purine Nucleosides / Q000138:chemical synthesis*
D001952:Bridged-Ring Compounds; D011684:Purine Nucleosides; D006151:Guanosine; D000241:Adenosine