title: Investigational strategies in autologous stem cell transplantation for follicular lymphoma.
abstract: Recent retrospective analyses indicate prolonged survival for patients with follicular lymphoma over the past 25 years, attributed most likely to improved supportive care and sequential application of effective therapies. Encouraging results were obtained from several randomized trials evaluating myeloablative therapy followed by autologous stem cell transplantation (ASCT) as consolidation therapy applied to patients with advanced-stage follicular lymphoma either in first remission or as salvage therapy. However, because of the successful introduction of rituximab to the standard therapeutic repertoire, with its long-term beneficial clinical impact, ASCT must be reevaluated in prospective clinical trials, especially taking into account the potential short- and long-term toxicity associated with high-dose therapy. The concept of in vivo purging before or after ASCT and the introduction of radioimmunotherapy as part of the myeloablative regimen may further improve treatment results, reduce toxicity, and increase applicability. Combination of these novel strategies into a multimodal approach justifies hope that the treatment outcome of patients suffering from follicular lymphoma will be further improved.
authors.affiliation: Department of Internal Medicine III, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Weigert
authors.forename: Martin
authors.initials: M
authors.lastname: Dreyling
authors.forename: Michael
authors.initials: M
authors.lastname: Unterhalt
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hiddemann
authors.forename: Christian
authors.initials: C
authors.lastname: Buske
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008224:Lymphoma, Follicular / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D016499:Radioimmunotherapy; D012074:Remission Induction; D014182:Transplantation, Autologous
chemical_list: D000911:Antibodies, Monoclonal