Synthetic studies toward the bryostatins: a substrate-controlled approach to the A-ring.
[reaction: see text] The synthesis of a C1-C13 A-ring subunit of bryostatin 1 is detailed. The key features of the approach include the convergent fragment assembly with a highly stereoselective construction of the C7-C8 bond indicated above.
Keck
Gary E
GE
Department of Chemistry, University of Utah, 315 South 1400 East RM 2020, Salt Lake City, Utah 84112-0850, USA. keck@chemistry.utah.edu
Welch
Dennie S
DS
Vivian
Paige K
PK
D000818:Animals; D054713:Bryostatins; D002013:Bryozoa / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D054713:Bryostatins; D018942:Macrolides; C046785:bryostatin 1