title: [Studies on the interaction of the metal complex of hydrazide of podophyllic acid with DNA].
abstract: The interaction between the metal complex of hydrazide of podophyllic acid and calf thymus (CT) DNA was studied by using absorption spectra, fluorescence spectra and DNA heat denaturation. It was found that the intensity of the maximal absorption peaks from absorption spectra is weakened in the presence of the metal complex of hydrazide of podophyllic acid compared with that in the absence of the metal complex. All the experimental results show that the intercalation mode was proved to exist between HDPP-Ni complexes and CT DNA.
authors.affiliation: Province Key Laboratory of Refined Chemistry, Hainan University, Haikou 570228, China.
authors.forename: Ping-Hong
authors.initials: PH
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Liu-Fang
authors.initials: LF
authors.lastname: Wang
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Song
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Qu
authors.forename: Ying-Qian
authors.initials: YQ
authors.lastname: Liu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; C507546:podophyllic acid; D004247:DNA; C427203:calf thymus DNA; D011034:Podophyllotoxin