[Negative correlation between BMD and HbA1C in patients with type 2 diabetes].
This study included 145 patients with type 2 diabetes, and 95 non-diabetic control. We measured bone mineral density (BMD) at the sites with different cortical/cancellous bone ratio (lumbar spine, femoral neck, and distal radius). BMD and Z score at the distal radius were significantly lower in type 2 diabetic patients than those in control subjects. In type 2 diabetic patients, negative correlation between BMD and the mean HbA(1C) during the last 2 years was found significantly at the distal radius in both sexes. These results indicate the selective cortical bone loss in type 2 diabetes, and suggest the importance of evaluating BMD at the radius as well and keeping good metabolic control to prevent bone loss in type 2 diabetic patients.
Komatsu
Yasato
Y
Kyoto University Graduate School of Medicine, Department of Medicine and Clinical Science.
Majima
Takafumi
T
D015519:Bone Density / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged
D006442:Glycated Hemoglobin; C025617:glucosylated hemoglobin A