title: Use of proton pump inhibitors during pregnancy and breastfeeding.
abstract: OBJECTIVE
  A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy.
  
  
  CONCLUSIONS
  Data currently available suggest that omeprazole is not teratogenic in humans. While information on other PPIs is limited, a systematic review of the evidence suggests that they are also not teratogenic.
authors.affiliation: Hospital for Sick Children in Torinto, Ont.
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Nava-Ocampo
authors.forename: Elvia Y
authors.initials: EY
authors.lastname: Velázquez-Armenta
authors.forename: Jung-Yeol
authors.initials: JY
authors.lastname: Han
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001942:Breast Feeding; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D054328:Proton Pump Inhibitors
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors