A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality.
BACKGROUND
To investigate the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality.


METHODS
We compared the occurrence of HLA-DR and HLA-DQ antigens in patients with intracranial saccular aneurysm and in the control group by PCR and agarose gel electrophoresis.


RESULTS
No statistically significant correlation between HLA-DR, HLA-DQ antigen frequency, and the pathogenesis and clinical characteristics of intracranial aneurysm has been found.


CONCLUSIONS
We have not found any relationship between HLA-DR and HLA-DQ antigen frequency, haplotype frequency, and pathogenesis and clinical characteristics of intracranial aneurysm, but the patients who presented with HLA-DR53, DR52, DQ7(3), and DQ5(1) seem to be more likely to bear multiple intracranial aneurysms.
Wang
Jiang-Fei
JF
Department of Neurosurgery, Beijing TianTan Hospital, Capital University of Medical Sciences, Beijing 100050, China. wjf1998@yeah.net
Zhang
Dong
D
Zhao
Ji-Zong
JZ
Jia
Bao-Xiang
BX
Bi
Ru-Mei
RM
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D002532:Intracranial Aneurysm / Q000208:ethnology* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens