title: [The molecular mechanism of Notch-induced transformation and the therapeutic potential of its inhibitor].
authors.forename: Shigeo
authors.initials: S
authors.lastname: Masuda
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D001381:Azepines / Q000737:chemistry / Q000494:pharmacology; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000502:physiology*; D014280:Triglycerides / Q000737:chemistry; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D001381:Azepines; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; C484278:N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; D051880:Receptors, Notch; D016212:Transforming Growth Factor beta; D014280:Triglycerides; D005680:gamma-Aminobutyric Acid; C057077:1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol; D053829:Amyloid Precursor Protein Secretases; D000409:Alanine