Severe dapsone hypersensitivity syndrome.
Dapsone, a potent antiparasitic and anti-inflammatory compound, is mainly used in the treatment of leprosy and a variety of blistering skin diseases. It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome. We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome. The clinical presentation mimicked a viral exanthema.
Sener
O
O
Division of Allergy, Gulhane Military Medical Academy, Ankara, Turkey. drosmansener@yahoo.com
Doganci
L
L
Safali
M
M
Besirbellioglu
B
B
Bulucu
F
F
Pahsa
A
A
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003622:Dapsone / Q000009:adverse effects*; D003874:Dermatitis Herpetiformis / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005076:Exanthema / Q000175:diagnosis; D005260:Female; D006801:Humans; D008708:Methemoglobinemia / Q000139:chemically induced; D013577:Syndrome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003622:Dapsone