title: [Ondine's Curse and rare oculomotor abnormalities: a case report].
abstract: Ondine's Curse or congenital central hypoventilation syndrome (CCHS) is a neurocristopathy (failure of migration or differentiation of neural crest-derived precursor cells) and is characterized by hypoventilation or apnea, which is most pronounced during sleep, with no other abnormalities of the neuro-respiratory system. Because of respiratory distress soon after birth, patients must be intubated and ventilated for a long time. This disorder may be associated with other symptoms of neurocristopathy (Hirschsprung disease, neuroblastoma, neuroganglioma) and other abnormalities of the autonomic nervous system (vasomotor dysfunctions or ophthalmic abnormalities: abnormal pupils, insufficient convergence, strabismus, or ptosis). We report the original case of a CCHS patient who presented with alternative ptosis of both the right and left eyes and esotropia. The ocular findings should lead to earlier diagnosis and speedier adequate treatment.
authors.affiliation: Clinique Ophtalmologique, Hôpital Civil, Hôpitaux Universitaires de Strasbourg. gmichel@télé2.fr
authors.forename: G
authors.initials: G
authors.lastname: Michel
authors.forename: F
authors.initials: F
authors.lastname: Villega
authors.forename: P
authors.initials: P
authors.lastname: Desprez
authors.forename: H
authors.initials: H
authors.lastname: Dollfus
authors.forename: C
authors.initials: C
authors.lastname: Speeg-Schatz
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015840:Oculomotor Nerve Diseases / Q000150:complications*; D020919:Sleep Disorders, Intrinsic / Q000150:complications* / Q000151:congenital*