In vivo detection of gray and white matter differences in GABA concentration in the human brain.
A novel selective multiple quantum filtering-based chemical shift imaging method was developed for acquiring GABA images in the human brain at 3 T. This method allows a concomitant acquisition of an interleaved total creatine image with the same spatial resolution. Using T(1)-based image segmentation and a nonlinear least square regression analysis of GABA-to-total creatine concentration ratios in frontal and parietal lobes of healthy adult volunteers as a function of the tissue gray matter fraction, the mean GABA concentration in gray and white matter was determined to be 1.30+/-0.36 micromol/g and 0.16+/-0.16 micromol/g (mean+/-SD, n=13), respectively. It is expected that this method will become a useful tool for studying GABAergic function in the human brain in vivo.
Choi
In-Young
IY
The Nathan Kline Institute, Medical Physics, Orangeburg, NY 10962, USA. ichoi@kumc.edu
Lee
Sang-Pil
SP
Merkle
Hellmut
H
Shen
Jun
J
D000328:Adult; D000465:Algorithms; D001923:Brain Chemistry / Q000502:physiology*; D002138:Calibration; D002555:Cerebrospinal Fluid / Q000502:physiology; D003401:Creatine / Q000378:metabolism; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016018:Least-Squares Analysis; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D017711:Nonlinear Dynamics; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D005978:Glutathione; D003401:Creatine