In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: A physicochemical and cyto-genotoxical study.
Although the current production of oxide nanoparticles may be modest, the wide range of proposed applications and forecasted growth in production has raised questions about the potential impact of these nanoparticles on the environment and human health. Iron oxide nanoparticles have been proposed for an increasing number of biomedical applications although in vitro toxicity depending on the particles coating has been evidenced. The aim of this study was to examine the potential in vitro cyto- and genotoxicity on human dermal fibroblasts of DMSA-coated maghemite nanoparticles (NmDMSA) as a function of well-defined physicochemical states. Well-stabilized NmDMSA produced weak cytotoxic and no genotoxic effects. This is attributed in part to the DMSA coating, which serves as a barrier for a direct contact between nano-oxide and fibroblasts, inhibiting a potential toxic effect.
Auffan
Melanie
M
CEREGE UMR 6635 CNRS-Université Paul Cézanne, Europôle de l'Arbois 13545 Aix-en-Provence, France. auffan@cerege.fr
Decome
Laetitia
L
Rose
Jerome
J
Orsiere
Thierry
T
De Meo
Michel
M
Briois
Valerie
V
Chaneac
Corinne
C
Olivi
Luca
L
Berge-Lefranc
Jean-Louis
JL
Botta
Alain
A
Wiesner
Mark R
MR
Bottero
Jean-Yves
JY
D005347:Fibroblasts / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D046529:Microscopy, Electron, Transmission; D009153:Mutagens / Q000633:toxicity*; D053758:Nanoparticles; D013057:Spectrum Analysis; D004113:Succimer / Q000633:toxicity*; D014965:X-Rays
D009153:Mutagens; D004113:Succimer