Development and in vitro evaluation of expandable gastroretentive dosage forms based on compressed collagen sponges.
The objective of this study was to develop and evaluate new collagen gastroretentive dosage forms (GRDFs) which expand in the stomach after contact with gastric fluids. The GRDFs should remain in the stomach for a prolonged period of time due to their size. The dosage forms were prepared from collagen sponges. The sponges were manufactured by freeze-drying a riboflavin-containing collagen solution. A computer controlled material supply was constructed to transport precompressed collagen into a tablet machine. A second type of tablet was manufactured by combining compressed collagen sponges with hydrophilic matrix layers of hydroxypropylmethylcellulose. Matrix layers containing captopril or aciclovir were developed. In vitro experiments were performed with both types of dosage forms. The collagen tablets expand within a few minutes after contact with artificial gastric juice and form a drug delivery system with a size of 8 mm x 18 mm x 60 mm. Riboflavin is released over 16 h. If two layer tablets are used, the release of aciclovir or captopril can be controlled by the composition of the sustained release layer.
Gröning
R
R
Institute of Pharmaceutical Technology and Biopharmaceutics, Westfalian Wilhelms-University, Münster, Germany. groenin@uni-muenster.de
Cloer
C
C
Müller
R S
RS
D000212:Acyclovir / Q000008:administration & dosage / Q000737:chemistry; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000737:chemistry; D002216:Captopril / Q000008:administration & dosage / Q000737:chemistry; D002417:Cattle; D003094:Collagen / Q000737:chemistry*; D004304:Dosage Forms; D005612:Freeze Drying; D005753:Gastric Mucosa / Q000378:metabolism*; D006358:Hot Temperature; D006851:Hydrochloric Acid; D008297:Male; D009333:Neck; D011489:Protein Denaturation; D012256:Riboflavin / Q000008:administration & dosage / Q000737:chemistry; D012867:Skin / Q000737:chemistry; D013607:Tablets; D014815:Vitamins / Q000008:administration & dosage / Q000737:chemistry
D000806:Angiotensin-Converting Enzyme Inhibitors; D000998:Antiviral Agents; D004304:Dosage Forms; D013607:Tablets; D014815:Vitamins; D003094:Collagen; D002216:Captopril; D006851:Hydrochloric Acid; D012256:Riboflavin; D000212:Acyclovir