title: Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteers.
abstract: Previously, we found that 4 weeks of treatment with lopinavir-ritonavir did not decrease insulin sensitivity but did increase adiponectin levels. In the present study, a single dose of lopinavir-ritonavir decreases insulin sensitivity but does not alter adiponectin levels. Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect.
authors.affiliation: Department of Medicine, University of California, San Francisco, California, USA. galee@itsa.ucsf.edu
authors.forename: Grace A
authors.initials: GA
authors.lastname: Lee
authors.forename: Joan C
authors.initials: JC
authors.lastname: Lo
authors.forename: Francesca
authors.initials: F
authors.lastname: Aweeka
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Schwarz
authors.forename: Kathleen
authors.initials: K
authors.lastname: Mulligan
authors.forename: Morris
authors.initials: M
authors.lastname: Schambelan
authors.forename: Carl
authors.initials: C
authors.lastname: Grunfeld
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000378:metabolism; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D004311:Double-Blind Method; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D061466:Lopinavir; D008297:Male; D008875:Middle Aged; D011744:Pyrimidinones / Q000008:administration & dosage* / Q000009:adverse effects; D019438:Ritonavir / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D052242:Adiponectin; D019380:Anti-HIV Agents; D001786:Blood Glucose; D007328:Insulin; D011744:Pyrimidinones; D061466:Lopinavir; D019438:Ritonavir