title: Language dominance in mesial temporal lobe epilepsy: a functional transcranial Doppler sonography study of brain plasticity.
abstract: Functional transcranial Doppler sonography was used to study hemispheric language dominance (HLD) in 24 right-handed patients with left temporal lobe epilepsy (TLE) and a structural lesion in the left temporal lobe and in 69 healthy controls. Twenty-five percent of the patients and 4% of controls showed atypical (right or bilateral) HLD. Degree of HLD was not correlated with age, Full Scale IQ, Verbal IQ, spike frequency, seizure frequency, age at seizure onset, or duration of TLE. Atypical HLD appears to be lesion-induced, independent of epilepsy characteristics.
authors.affiliation: Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Rudolf-Bultmann-Strasse 8, 35033 Marburg, Germany. knake@staff.uni-marburg.de
authors.forename: Susanne
authors.initials: S
authors.lastname: Knake
authors.forename: Anja
authors.initials: A
authors.lastname: Haag
authors.forename: Guido
authors.initials: G
authors.lastname: Pilgramm
authors.forename: Christine
authors.initials: C
authors.lastname: Dittmer
authors.forename: Janine
authors.initials: J
authors.lastname: Reis
authors.forename: Heike
authors.initials: H
authors.lastname: Assmann
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
authors.forename: Felix
authors.initials: F
authors.lastname: Rosenow
authors.forename: Hajo M
authors.initials: HM
authors.lastname: Hamer
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004292:Dominance, Cerebral; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity; D011300:Preoperative Care; D012016:Reference Values; D012598:Sclerosis; D017585:Ultrasonography, Doppler, Transcranial