[Interstitial telomere repeats as markers of evolutionary changes in the mammalian karyotype: human chromosome 2].
Telomer repeats represented by hexamer (TTAGGG)n at chromosome termini are required for correct function and chromosome stability. At the same time, interstitial telomer sequence (ITS) located far from the chromosome ends are known for several mammalian genomes, including the human genome. It is assumed that these repeats mark the points of fusion or other chromosome reconstructions of ancestors. Exact localization of all interstitial telomer sequences in the genome could greatly improve our understanding of the mechanism of karyotype evolution and species origin. We have developed a software for a search of interstitial telomer sequences in complete sequences of mammalian genomes. We have demonstrated the evolutionary significance of repeats by an example of human chromosome 2. The results and supplementary materials are available at the site of the Institute of Cytology and Genetics: http://www.bionet.nsc.ru/labs/theorylabmain/orlov/telomere/.
Vorob'ev
N V
NV
Biltueva
L S
LS
Orlov
Iu L
IuL
Grafodatskiĭ
A S
AS
Kolchanov
N A
NA
D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software; D016615:Telomere / Q000235:genetics*