title: Ibuprofen-induced fever in Sjogren's syndrome.
abstract: A 68-year-old woman with a medical history significant for Sjögren syndrome and leukocytoclastic vasculitis of small vessels presented to the emergency department with chills, malaise, a temperature of 39 degrees C, nausea, vomiting, and hypotension. Fifteen minutes earlier she had taken ibuprofen for flu-like symptoms. She was treated with a perfusion of intravenous saline, paracetamol, and ciprofloxacin with improvement 24 hours later. Three months later, she had a similar episode, without hypotension. An oral challenge test with ibuprofen in the hospital produced the same symptoms 3 hours after the last dose. She was treated with metamizole and paracetamol and was asymptomatic the next day. This is the first report of a febrile reaction to ibuprofen in a patient with Sjogren's syndrome.
authors.affiliation: Allergology Department, Infanta Cristina University Hospital, Badajoz, Spain. magonzalog@telefonica.net
authors.forename: M A
authors.initials: MA
authors.lastname: Gonzalo-Garijo
authors.forename: P
authors.initials: P
authors.lastname: Bobadilla
mesh_terms: D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000209:etiology / Q000276:immunology; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008582:Meningitis, Aseptic / Q000209:etiology / Q000276:immunology; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy* / Q000276:immunology
chemical_list: D018712:Analgesics, Non-Narcotic; D007052:Ibuprofen