title: [Combination chemotherapy study of biweekly paclitaxel and S-1 administration in patients with advanced gastric cancer].
abstract: In the present article, we report the results of phase I/II combination chemotherapy study of biweekly paclitaxel and S-1 administration in patients with advanced gastric cancer. In the phase I study, we could determine the recommended dose for the phase II study with paclitaxel and S-1 to be 120 mg/m2 and 80 mg/m2, respectively. The side effect was not so severe. The overall response was 53%. In conclusion, biweekly paclitaxel and S-1 administration can be safely combined for the treatment of advanced gastric cancer. This combined therapy represents a novel and active treatment regimen with low toxicity and can be defined as safe and effective. Now we are analyzing the result of the phase II study.
authors.affiliation: Dept of Surgery, Imamura Hospital, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hokita
authors.forename: Takashi
authors.initials: T
authors.lastname: Aikou
authors.forename: Sumiya
authors.initials: S
authors.lastname: Ishigami
authors.forename: Futoshi
authors.initials: F
authors.lastname: Miyazono
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nakajo
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Uenosono
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hamanoue
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Aridome
authors.forename: Shouji
authors.initials: S
authors.lastname: Natsugoe
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000505:Alopecia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D020714:Maximum Tolerated Dose; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel