title: Comparison of classifications for heart failure in children undergoing valvular surgery.
abstract: OBJECTIVE
  To characterize correlations between clinical classifications of heart failure and diagnostic workup.
  
  
  METHODS
  Pre- and postoperative characteristics of 20 children with heart failure secondary to valvular rheumatic disease were studied.
  
  
  RESULTS
  Both scoring systems correlated with N-terminal pro-brain natriuretic peptide (N-proBNP) but not with troponin I (TnI). The PHFI correlated with N-proBNP, end-systolic wall stress, left ventricular mass index and left atrium to aorta diameter ratio. No correlation could be established between modified Ross score, or the New York Heart Association (NYHA) grade and echocardiographic measurements. Cardiothoracic and Sokolow indexes were correlated with the PHFI as well as to the NYHA classification.
  
  
  CONCLUSIONS
  In this study, PHFI seems better correlated with radiologic, electrocardiographic, echocardiographic, and biologic assessment of heart failure in children. Clinical severity was correlated with N-proBNP but not with TnI.
authors.affiliation: Cardiology Unit, Children's Hospital of Geneva, Geneva, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Tissières
authors.forename: Yacine
authors.initials: Y
authors.lastname: Aggoun
authors.forename: Eduardo
authors.initials: E
authors.lastname: Da Cruz
authors.forename: Jorge
authors.initials: J
authors.lastname: Sierra
authors.forename: Noury
authors.initials: N
authors.lastname: Mensi
authors.forename: Afksendyios
authors.initials: A
authors.lastname: Kalangos
authors.forename: Maurice
authors.initials: M
authors.lastname: Beghetti
mesh_terms: D001921:Brain / Q000378:metabolism; D006348:Cardiac Surgical Procedures / Q000379:methods; D002648:Child; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000473:pathology; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D006351:Heart Valves / Q000473:pathology* / Q000601:surgery*; D006352:Heart Ventricles / Q000473:pathology; D006529:Hepatomegaly / Q000150:complications; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D012214:Rheumatic Heart Disease / Q000150:complications / Q000473:pathology; D012720:Severity of Illness Index; D014336:Troponin / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; D014336:Troponin; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain