title: Gene expression in fibroadenomas of the rat mammary gland in contrast to spontaneous adenocarcinomas and normal mammary gland.
abstract: Fibroadenomas are considered a benign lesion in rodent carcinogenicity studies. However, the entity adenocarcinoma arising in fibroadenoma does exist and in humans there is evidence of certain forms of fibroadenomas to confer greater risk of subsequent breast cancer. In this study, we aim to elucidate the molecular features of both spontaneous fibroadenomas and adenocarcinomas. The gene expression of the two tumour types is examined and compared to mammary gland in the same developmental state and examined for similarities which might indicate common molecular pathways. In the present study no similarities were discovered. We conclude that in the tumours examined here, no progression to adenocarcinoma is likely. Further studies are needed, examining a greater number of tumours and including cases of adenocarcinoma arising in fibroadenoma.
authors.affiliation: Preclinical Safety, Novartis Pharma AG, Basel, Switzerland. heike.marxfeld@eur.crl.com
authors.forename: Heike
authors.initials: H
authors.lastname: Marxfeld
authors.forename: Frank
authors.initials: F
authors.lastname: Staedtler
authors.forename: Johannes H
authors.initials: JH
authors.lastname: Harleman
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D005260:Female; D018226:Fibroadenoma / Q000235:genetics*; D020869:Gene Expression Profiling; D007150:Immunohistochemistry; D008321:Mammary Glands, Animal / Q000378:metabolism*; D015674:Mammary Neoplasms, Animal / Q000235:genetics*; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018800:Thy-1 Antigens / Q000032:analysis / Q000235:genetics
chemical_list: D018800:Thy-1 Antigens; D003094:Collagen; D010751:Phosphopyruvate Hydratase