A convenient and genuine equivalent to HZrCp2Cl generated in situ from ZrCp2Cl2-DIBAL-H.
[reaction: see text] Slow addition of 1 equiv of (i)Bu2AlH to ZrCp2Cl2 in THF provides a convenient route to either HZrCp2Cl-(i)Bu2AlCl (Reagent I) or HZrCp2Cl (Reagents II and III). The latter represents a highly convenient route to genuine HZrCp2Cl, while Reagent I is useful for regio- and stereoselective conversion of 1- and 2-alkynes into (E)-1-iodo-1-alkenes and (E)-2-iodo-2-alkenes, respectively.
Huang
Zhihong
Z
Herbert C. Brown Laboratories of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, USA.
Negishi
Ei-ichi
E
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry*
D000475:Alkenes; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D015040:Zirconium