title: Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.
abstract: Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
authors.affiliation: Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland. Mirjana.Tosic@chuv.ch
authors.forename: Mirjana
authors.initials: M
authors.lastname: Tosic
authors.forename: Jurg
authors.initials: J
authors.lastname: Ott
authors.forename: Sandra
authors.initials: S
authors.lastname: Barral
authors.forename: Pierre
authors.initials: P
authors.lastname: Bovet
authors.forename: Patricia
authors.initials: P
authors.lastname: Deppen
authors.forename: Fulvia
authors.initials: F
authors.lastname: Gheorghita
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Matthey
authors.forename: Josef
authors.initials: J
authors.lastname: Parnas
authors.forename: Martin
authors.initials: M
authors.lastname: Preisig
authors.forename: Michael
authors.initials: M
authors.lastname: Saraga
authors.forename: Alessandra
authors.initials: A
authors.lastname: Solida
authors.forename: Sally
authors.initials: S
authors.lastname: Timm
authors.forename: August G
authors.initials: AG
authors.lastname: Wang
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.forename: Michel
authors.initials: M
authors.lastname: Cuénod
authors.forename: Kim Quang
authors.initials: KQ
authors.lastname: Do
mesh_terms: D016022:Case-Control Studies; D015536:Down-Regulation; D005347:Fibroblasts / Q000201:enzymology / Q000378:metabolism; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005721:Glutamate-Cysteine Ligase / Q000235:genetics*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000032:analysis; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione