[Multifocal colonization and hydrolytic activity of Candida strains isolated from lung cancer patients].
The aim was looking for correlation between hydrolytic activity and multifocal Candida invasions in 33 lung cancer patients (LC) before treatment. Materials used in this study were pharyngeal and rectal swab, sputum, bronchial secretion and urine. Isolation and identification of fungi were performed using ID C 32 test and the hydrolytic activity using API ZYM test.


RESULTS
1/ there were only Candida strains, especially C. albicans (78,8 %) isolated 2/ Candida in more than one sample were present in 74%, in three or four in 27,7% of LC. 3/ Candida strains produced 17 among 19 investigated enzymes 4/ there were statistically significant correlations between the activity of some hydrolytic enzymes and number of Candida foci observed.


CONCLUSIONS
1/ the results confirmed the influence of Candida hydrolytic activity on the course of infection. 2/ hydrolytic enzymes activity is one of important Candida pathogenicity factors.
Batura-Gabryel
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Katedra i Klinika Ftyzjopneumonologii, 60-569 Poznań ul. Szamarzewskiego 84.
D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002175:Candida / Q000145:classification / Q000201:enzymology* / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D006867:Hydrolases / Q000378:metabolism*; D008175:Lung Neoplasms / Q000150:complications / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000382:microbiology; D013183:Sputum / Q000382:microbiology; D013909:Thorax / Q000382:microbiology
D006867:Hydrolases