Probing selectivity in recognition-mediated dynamic covalent processes.
[reaction: see text] Two simple recognition-mediated dynamic Diels-Alder systems are used to probe the role of kinetics and thermodynamics in determining the equilibrium position in exchanging libraries and the time taken to reach that equilibrium. The selectivity expressed by recognition-driven dynamic processes is demonstrated to be less than the free-energy difference between the components as a result of compensatory effects arising from the extent of conversion to products within the library.
Bennes
Raphael M
RM
EaStCHEM and Centre for Biomolecular Sciences, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, United Kingdom.
Philp
Douglas
D