title: Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis.
abstract: Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10-year-old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associated with mild pancreatitis. Hypertriglyceridemia was successfully managed with plasmapheresis with a decrease in triglyceride levels to 590 mg/dl. Apheresis appears to be safe and effective in reducing hypertriglyceridemia and preventing related complications.
authors.affiliation: Department of Pediatric Oncology, Catholic University of Rome, Rome, Italy. vita.ridola@rm.unicatt.it
authors.forename: Vita
authors.initials: V
authors.lastname: Ridola
authors.forename: Paola Sabrina
authors.initials: PS
authors.lastname: Buonuomo
authors.forename: Palma
authors.initials: P
authors.lastname: Maurizi
authors.forename: Rossana
authors.initials: R
authors.lastname: Putzulu
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Annunziata
authors.forename: Domenico
authors.initials: D
authors.lastname: Pietrini
authors.forename: Riccardo
authors.initials: R
authors.lastname: Riccardi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000209:etiology / Q000628:therapy*; D007937:Leukapheresis; D008297:Male; D010956:Plasmapheresis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy / Q000628:therapy; D012074:Remission Induction; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D001215:Asparaginase