HIV-1 drug resistance genotype results in patients with plasma samples with HIV-1 RNA levels less than 75 copies/mL.
HIV-1 genotypic resistance test results were obtained on clinical samples from 116 patients with plasma HIV-1 RNA levels of less than 75 copies/mL. Genotype validity was confirmed in 49 of 50 patients with a previous or follow-up genotype. The belief that genotypic resistance testing is unreliable in samples with low-level viremia should be reassessed.
Mitsuya
Yumi
Y
Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford 94305, and Kaiser-Permanente Medical Care Program-Northern California, Oakland, CA, USA.
Winters
Mark A
MA
Fessel
W Jeffrey
WJ
Rhee
Soo-Yon
SY
Slome
Sally
S
Flamm
Jason
J
Horberg
Michael
M
Hurley
Leo
L
Klein
Daniel
D
Shafer
Robert W
RW
D019380:Anti-HIV Agents / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral / Q000097:blood* / Q000235:genetics* / Q000302:isolation & purification; D019562:Viral Load
D019380:Anti-HIV Agents; D012367:RNA, Viral