title: Novel seco-dibenzopyrrocoline alkaloid from Cryptocarya oubatchensis.
abstract: [structure: see text] A novel seco-dibenzopyrrocoline alkaloid, named oubatchensine 6, and five phenanthroindolizidines (1-5) were isolated from Cryptocarya oubatchensis, and their structures were elucidated. Displacement centrifugal partition chromatography was used to purify compounds 1 and 6. Structure determination of the latter was carried out by mass spectrometry, NMR spectroscopy, quantum chemistry, and computer-assisted structure determination. Cytotoxic activity against KB cells was then investigated.
authors.affiliation: FRE 2715 (IFR 53), UMR 6519, and UMR 6089, Université de Reims Champagne-Ardenne, Moulin de la Housse, BP 1039, 51687 Reims Cedex 2, France.
authors.forename: Alix
authors.initials: A
authors.lastname: Toribio
authors.forename: Aurélie
authors.initials: A
authors.lastname: Bonfils
authors.forename: Eldra
authors.initials: E
authors.lastname: Delannay
authors.forename: Elise
authors.initials: E
authors.lastname: Prost
authors.forename: D
authors.initials: D
authors.lastname: Harakat
authors.forename: Eric
authors.initials: E
authors.lastname: Henon
authors.forename: Bernard
authors.initials: B
authors.lastname: Richard
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Nuzillard
authors.forename: Jean-Hugues
authors.initials: JH
authors.lastname: Renault
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031369:Cryptocarya / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; C520161:oubatchensine