title: Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis.
abstract: Mastitis (mammary gland inflammation) is one of the most important bovine diseases causing economic losses to dairy producers. Mammary gland inflammation is a consequence of the activity of a number of cell and soluble factors that function together to eliminate invading microorganisms. The factors involved in this inflammatory response differ depending on the infectious agent. This review analyzes the factors involved in the immunologic mechanisms against the main pathogenic bacteria causing mastitis, and emphasizes the innate immune response of the mammary gland. Knowledge, at the molecular level, of the mammary gland immune response during infection by pathogenic bacteria is fundamental to the design of effective therapies to control and eradicate bovine mastitis.
authors.affiliation: Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Apdo. Postal 53, Administración Chapultepec, C.P. 58262 Morelia, Michoacán, México.
authors.forename: Javier
authors.initials: J
authors.lastname: Oviedo-Boyso
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Valdez-Alarcón
authors.forename: Marcos
authors.initials: M
authors.lastname: Cajero-Juárez
authors.forename: Alejandra
authors.initials: A
authors.lastname: Ochoa-Zarzosa
authors.forename: Joel E
authors.initials: JE
authors.lastname: López-Meza
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bravo-Patiño
authors.forename: Víctor M
authors.initials: VM
authors.lastname: Baizabal-Aguirre
mesh_terms: D000818:Animals; D002417:Cattle; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006090:Gram-Negative Bacteria / Q000472:pathogenicity*; D006095:Gram-Positive Cocci / Q000472:pathogenicity*; D007113:Immunity, Innate; D008321:Mammary Glands, Animal / Q000276:immunology* / Q000382:microbiology; D008414:Mastitis, Bovine / Q000382:microbiology*
chemical_list: D016207:Cytokines