title: PANDAS (Paediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection).
abstract: PANDAS (Paediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection) is a rare condition first described in 1998. It describes the presence of obsessive-compulsive disorder (OCD) or tics with an episodic course, and a temporal relationship to Group A beta haemolytic streptococcal infection (GABHS). Recurrent episodes can be disruptive and upsetting for a child, but the best way to treat the condition has yet to be established. Penicillin prophylaxis has not proved effective, and other therapies are experimental. There is some evidence in the literature to support the role of tonsillectomy in improving the condition. We report a case of a 6-year-old boy who presented with tic and hemi-chorea associated with GABHS throat infection. He had a recurrence of his symptoms associated with a further GABHS infection, but has had no further symptoms following tonsillectomy. This case report lends further evidence to the role of tonsillectomy in the management of PANDAS.
authors.affiliation: Department of Paediatrics, Royal College of Surgeons in Ireland Medical School, Dublin.
authors.forename: N E
authors.initials: NE
authors.lastname: Lynch
authors.forename: S
authors.initials: S
authors.lastname: Deiratany
authors.forename: D W
authors.initials: DW
authors.lastname: Webb
authors.forename: J B
authors.initials: JB
authors.lastname: McMenamin
mesh_terms: D002648:Child; D006801:Humans; D008297:Male; D010406:Penicillins / Q000627:therapeutic use; D013290:Streptococcal Infections / Q000150:complications* / Q000188:drug therapy; D013297:Streptococcus pyogenes / Q000302:isolation & purification / Q000472:pathogenicity*; D013981:Tic Disorders / Q000150:complications* / Q000188:drug therapy
chemical_list: D010406:Penicillins