Long-term retention of dye after indocyanine green-assisted internal limiting membrane peeling.
OBJECTIVE
To evaluate dye retention in the fundus after indocyanine green (ICG)-assisted internal limiting membrane peeling.


METHODS
Ten eyes with stage 3 or 4 nondiabetic idiopathic macular hole (MH group) and six eyes with diffuse diabetic macular edema (DM group) were studied. The fundus was examined with 780-nm infrared illumination by a scanning laser ophthalmoscope (SLO) after ICG-assisted internal limiting membrane peeling. The postoperative follow-up period ranged from 6 to 12 months (mean+/-SD, 3.7+/-2.6 months).


RESULTS
Fluorescence from ICG was detected in all studied eyes in both groups up to 6 months after surgery. At 9 months after surgery, ICG fluorescence was visible in all eyes of the DM group, but in only one-third of eyes of the MH group. No fluorescence was detected in fellow eyes that had not been operated on.


CONCLUSIONS
The present study using SLO revealed that ICG remains in the fundus for over 6 months after surgery. The results also suggested that a longer time might be required for dye clearance from the diabetic retina than from the nondiabetic retina.
Ashikari
Masayuki
M
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan. ma-kou@t-gh.bias.ne.jp.
Ozeki
Hironori
H
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
Tomida
Kazuyuki
K
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
Sakurai
Eiji
E
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
Tamai
Kazushi
K
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
Ogura
Yuichiro
Y
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
D000368:Aged; D004396:Coloring Agents / Q000493:pharmacokinetics*; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008269:Macular Edema / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods; D012167:Retinal Perforations / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D014821:Vitrectomy / Q000379:methods*; D014822:Vitreous Body / Q000378:metabolism* / Q000601:surgery / Q000648:ultrastructure
D004396:Coloring Agents; D007208:Indocyanine Green