title: [Multiple hepatic metastases of colon cancer responding to combined therapy with TS-1 and CPT-11--a case report].
abstract: We treated a patient with multiple liver metastases arising from colon cancer in whom the metastatic tumors were responsive to treatment with the combination of TS-1 and CPT-11. The patient was a 71-year-old woman with cancer of the ascending colon and metastatic hepatic tumors. She had undergone surgery on July 28, 2004, and abdominal contrast CT scans obtained after discharge from hospital revealed numerous LDA (low-density areas) in both lobes of the liver. The patient was given ambulatory chemotherapy with TS-1 (120 mg/day on days 1-14) and CPT-11 (100 mg/day on days 1 and 8). After completion of 2 courses of chemotherapy, abdominal contrast CT scans revealed that most of the LDAs in both lobes of the liver had disappeared, and the patient was judged to have achieved PR. No adverse reactions were observed except for a slight decrease of WBC, and her chemotherapy is being continued at present. This case suggests that the combination of TS-1 and CPT-11 may be an effective form of chemotherapy for the treatment of colon cancer with multiple hepatic metastases.
authors.affiliation: Dept. of Surgery, Jikei University School of Medicine.
authors.forename: Takashi
authors.initials: T
authors.lastname: Mouri
authors.forename: Masaichi
authors.initials: M
authors.lastname: Ogawa
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Mitsuyama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamagata
authors.forename: Makoto
authors.initials: M
authors.lastname: Kosuge
authors.forename: Takuro
authors.initials: T
authors.lastname: Ushigome
authors.forename: Ken
authors.initials: K
authors.lastname: Eto
authors.forename: Michiaki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Sadao
authors.initials: S
authors.lastname: Anazawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D003110:Colonic Neoplasms / Q000473:pathology*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D010094:Oxonic Acid / Q000008:administration & dosage; D012074:Remission Induction; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002166:Camptothecin