Tacrolimus treatment for refractory lupus cystitis.
A 23-year-old woman presented with recurrence of lupus cystitis, which had been in remission under daily administration of a single corticosteroid over a period of 8 years. She was treated with increased doses of corticosteroid and immunosuppressants, i.e., cyclosporin, cyclophosphamide, azathioprine, and salazosulfapyridine, but the cystitis remained active. Since her condition became critical by the complication of intestinal pseudo-obstruction, tacrolimus was administered. This agent induced a remission promptly without significant adverse events in this patient, suggesting an efficacy to lupus cystitis refractory to corticosteroid and other immunosuppressants.
Maruoka
Hiroshi
H
Department of Medicine, Division of Respiratology and Neurology, Kurume University School of Medicine, 67 Asahimachi, Kurume, 830-0011, Japan. maruoka@med.kurume-u.ac.jp
Honda
Seiyo
S
Takeo
Masaaki
M
Koga
Takeharu
T
Fukuda
Takaaki
T
Aizawa
Hisamichi
H
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D003556:Cystitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging / Q000209:etiology; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007418:Intestinal Pseudo-Obstruction / Q000000981:diagnostic imaging / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D011859:Radiography; D016559:Tacrolimus / Q000008:administration & dosage*; D014463:Ultrasonography
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016559:Tacrolimus