Novel approaches in allogeneic stem cell transplantation.
Allogeneic transplantation remains an integral part of the management of hematologic malignancies. However, transplant-related mortality, graft-versus-host disease, and disease recurrence continue to be major limitations to successful transplant outcomes and challenges to investigators in the field. Newer approaches have focused on reduction of the intensity of the conditioning regimens, harnessing the antitumor effects of the allograft, and development of adoptive immunotherapy strategies to circumvent the limitations. These developments provide physicians with the ability to tailor transplants to specific patients and their diseases.
Papadopoulos
Esperanza B
EB
Department of Medicine, Adult Allogeneic Bone MarrowTransplantation Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. papadope@mskcc.org
Jakubowski
Ann A
AA
D002986:Clinical Trials as Topic; D006086:Graft vs Host Disease / Q000517:prevention & control*; D019337:Hematologic Neoplasms / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive; D019520:Living Donors; D033581:Stem Cell Transplantation / Q000379:methods*; D014184:Transplantation, Homologous