title: Developing somatosensory projections bypass periventricular brain lesions.
abstract: The authors studied four hemiparetic patients with large unilateral periventricular brain lesions acquired during the early third trimester of pregnancy. fMRI and magnetoencephalography demonstrated that the primary somatosensory representation of their paretic hands was nevertheless located in the contralateral rolandic cortex. Thus, outgrowing thalamocortical somatosensory projections had apparently bypassed the lesion to reach their original cortical destination. Such somatosensory projections curving around the lesion were effectively visualized by magnetic resonance diffusion tractography.
authors.affiliation: Department of Pediatric Neurology and Developmental Medicine, University Children's Hospital, Tübingen, Germany. martin.staudt@med.uni-tuebingen.de
authors.forename: M
authors.initials: M
authors.lastname: Staudt
authors.forename: C
authors.initials: C
authors.lastname: Braun
authors.forename: C
authors.initials: C
authors.lastname: Gerloff
authors.forename: M
authors.initials: M
authors.lastname: Erb
authors.forename: W
authors.initials: W
authors.lastname: Grodd
authors.forename: I
authors.initials: I
authors.lastname: Krägeloh-Mann
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D020644:Midline Thalamic Nuclei / Q000473:pathology*; D010291:Paresis / Q000473:pathology; D013003:Somatosensory Cortex / Q000473:pathology*