title: Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI.
abstract: Viable tissues at risk of infarction in acute stroke patients have been hypothesized to be detectable as volumetric mismatches between lesions on perfusion-weighted (PWI) and diffusion-weighted magnetic resonance imaging (DWI). Because tissue response to ischaemic injury and to therapeutic intervention is tissue- and patient-dependent, changes in infarct progression due to treatment may be better detected with voxel-based methods than with volumetric mismatches. Acute DWI and PWI were combined using a generalized linear model (GLM) to predict infarction risk on a voxel-wise basis for patients treated either with non-thrombolytic (Group 1; n = 11) or with thrombolytic therapy (Group 2; n = 27). Predicted infarction risk for both groups was evaluated in four ipsilateral regions of interest: tissue acutely abnormal on DWI (Core), tissue acutely abnormal on PWI but normal on DWI that either infarcts (Recruited) or does not (Salvaged), and tissue normal on both DWI and PWI that does not infarct (Normal) by follow-up imaging > or = 5 days. The performance of the models was significantly reduced for the thrombolysed group compared with the group receiving standard treatment, suggesting an alteration in natural progression of the ischaemic cascade. Average GLM-predicted infarction risk values in the four regions were different from one another for both groups. GLM-predicted infarction risk in Salvaged tissue was significantly higher (P = 0.02) for thrombolysed patients than for non-thrombolysed patients, suggesting that thrombolysis rescued tissue with higher infarction risk than typically measured in tissue that spontaneously recovered. The observed spatial heterogeneity of GLM-predicted infarction risk values probably reflects the varying degrees of tissue injury and salvageability that exist after stroke. MRI-based algorithms may therefore provide a more sensitive means for monitoring therapeutic effects on a voxel-wise basis.
authors.affiliation: Center for Functionally Integrative Neuroscience, Department of Neuroradiology, Arhus University Hospital, Arhus C, Denmark. ona@pet.auh.dk
authors.forename: Ona
authors.initials: O
authors.lastname: Wu
authors.forename: Søren
authors.initials: S
authors.lastname: Christensen
authors.forename: Niels
authors.initials: N
authors.lastname: Hjort
authors.forename: Rick M
authors.initials: RM
authors.lastname: Dijkhuizen
authors.forename: Thomas
authors.initials: T
authors.lastname: Kucinski
authors.forename: Jens
authors.initials: J
authors.lastname: Fiehler
authors.forename: Götz
authors.initials: G
authors.lastname: Thomalla
authors.forename: Joachim
authors.initials: J
authors.lastname: Röther
authors.forename: Leif
authors.initials: L
authors.lastname: Østergaard
mesh_terms: D000208:Acute Disease; D000368:Aged; D000465:Algorithms; D001921:Brain / Q000098:blood supply; D020520:Brain Infarction / Q000209:etiology / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D016014:Linear Models; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D015912:Thrombolytic Therapy / Q000379:methods