Pleural malignant solitary fibrous tumor with sarcomatous overgrowth showing PDGFRbeta mutation.
Pleural malignant solitary fibrous tumors (SFTs) are uncommon, and little is known about their histogenesis and molecular features. We report a case of pleural SFT with sarcomatous overgrowth that showed expression for PDGFRbeta and a missense mutation on exon 18 of the PDGFRbeta gene. The involvement of the PDGFRbeta gene in SFT is compatible with a pericytic derivation, also supporting a possible role of this tyrosine kinase in malignant transformation and in the adoption of novel molecular therapies.
Rossi
Giulio
G
Section of Pathologic Anatomy, University of Modena and Reggio Emilia, Modena, Italy. rossi.giulio@unimo.it
Schirosi
Laura
L
Giovanardi
Filippo
F
Sartori
Giuliana
G
Paci
Massimiliano
M
Cavazza
Alberto
A
D000368:Aged; D001706:Biopsy; D001999:Bronchoscopy; D004273:DNA, Neoplasm / Q000235:genetics*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009154:Mutation; D018218:Neoplasms, Fibrous Tissue / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D010997:Pleural Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics*; D012509:Sarcoma / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014057:Tomography, X-Ray Computed
D004273:DNA, Neoplasm; D020797:Receptor, Platelet-Derived Growth Factor beta