title: Effects of ulinastatin on postoperative systemic inflammatory response of recipients of rat small bowel transplantation.
abstract: OBJECTIVE
  We sought to evaluate the effects of ulinastatin on postoperative systemic inflammatory responses of recipients of rat small bowel transplantations (SBT).
  
  
  METHODS
  Twenty-four recipients of rat heterotopic SBT were randomly divided into a control group and a treated group. Ulinastatin (50,000 U/kg(-1)/d(-1)) was injected intravenously 30 minutes before graft revascularization. Measured variables included plasma concentrations of tumor necrosis factor (TNF), interleukin (IL)-6, and C-reactive protein (CRP) on postoperative days 1 and 3.
  
  
  RESULTS
  Administration of ulinastatin attenuated the postoperative increases in plasma concentrations of TNF, IL-6, and CRP.
  
  
  CONCLUSIONS
  Ulinastatin attenuated the postoperative systemic inflammatory response of rat recipients of SBT.
authors.affiliation: Department of Operation, Qilu Hospital of Shandong University, Shandong, China.
authors.forename: J-L
authors.initials: JL
authors.lastname: Sun
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Yu
authors.forename: R
authors.initials: R
authors.lastname: Ma
authors.forename: Y
authors.initials: Y
authors.lastname: Dai
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Fan
authors.forename: J-Z
authors.initials: JZ
authors.lastname: Sun
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D006023:Glycoproteins / Q000494:pharmacology*; D007249:Inflammation / Q000503:physiopathology*; D015850:Interleukin-6 / Q000097:blood; D007421:Intestine, Small / Q000637:transplantation*; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D014185:Transplantation, Isogeneic / Q000502:physiology; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015415:Biomarkers; D006023:Glycoproteins; D015850:Interleukin-6; D014361:Trypsin Inhibitors; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; C028665:urinastatin