Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer.
OBJECTIVE
Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin cause gastric ulcer. In order to study the gastroprotective effect of Cissus quadrangularis extract (CQE), this study was undertaken on aspirin-induced ulcerogenesis in pyloric ligated (ASP-PL) model in rats.


METHODS
To assess the possible antiulcer effect of CQE, lesion index, gastric secretions glycoprotein levels, non-protein sulphydryls (NPSH) and adherent mucus content were determined in ASP-PL induced gastric mucosal injury in rats.


RESULTS
Pretreatment with CQE significantly prevented the gastric mucosal lesion development and decreased the gastric toxicity produced by ulcerogen. In addition, ulcerated rats showed depletion of gastric wall mucus, glycoproteins and NPSH levels whereas treatment with CQE reverted this decline in ASP-PL induced rats. Histological studies confirmed the results.


CONCLUSIONS
The present finding suggests that CQE promotes ulcer protection by the decrease in ulcer index, gastric secretions and increase in the glycoprotein level, gastric mucin content and NPSH concentration. CQE may protect the gastric mucosa against ulceration by its antisecretory and cytoprotective property.
Jainu
Mallika
M
Department of Biochemistry, University of Madras, Chennai, India. malsleo80@yahoo.co.in
Vijai Mohan
K
K
Shyamala Devi
C S
CS
D000704:Analysis of Variance; D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D032422:Cissus / Q000737:chemistry*; D005750:Gastric Juice / Q000737:chemistry; D006023:Glycoproteins / Q000032:analysis; D006403:Hematologic Tests; D008297:Male; D010088:Oxidoreductases / Q000032:analysis; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology*
D006023:Glycoproteins; D010936:Plant Extracts; D010088:Oxidoreductases