Immunological memory is compromised by food restriction in deer mice Peromyscus maniculatus.
The immune system protects organisms against infection, but this protection presumably comes at a cost. Here, we asked whether food restriction would compromise the ability of an organism to generate an immune response on reexposure to an antigen, which would represent a functional cost of immunological memory. Immunological memory is generated when B and T lymphocytes sensitive to components of pathogens (i.e., antigens) proliferate after exposure and persist in circulation to hinder reinfection. To test the possibility that B cell memory, the component of the immune system responsible for antibody production, is expensive to maintain, secondary antibody production against a novel protein [keyhole limpet hemocyanin (KLH)] was compared in food-restricted and ad libitum-fed male deer mice (Peromyscus maniculatus). To determine whether compromised secondary antibody production was solely due to elevated corticosterone independent of resource availability, some food-restricted and ad libitum-fed mice were subjected to unpredictable, chronic (2 h/day) restraint. Mice fed 70% of their ad libitum diet 2 wk after primary antigen challenge produced approximately 95% less IgG against KLH after a second antigen challenge than mice fed ad libitum, even though all mice were fed ad libitum during the secondary antibody response period. Restraint had no effect on secondary IgG production in response to KLH, and corticosterone concentrations 1 day after food restriction did not differ between food-restricted and ad libitum-fed mice. Together, these data imply that secondary antibody responses and the benefits of immunological memory are energetically costly in this species.
Martin
Lynn B
LB
Department of Psychology, The Ohio State University, Columbus, OH 43210-1287, USA. lmartin@mail.psy.ohio-state.edu
Navara
Kristen J
KJ
Weil
Zachary M
ZM
Nelson
Randy J
RJ
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D031204:Caloric Restriction; D003345:Corticosterone / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D006433:Hemocyanins / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007156:Immunologic Memory / Q000502:physiology*; D008297:Male; D009929:Organ Size / Q000502:physiology; D010542:Peromyscus / Q000502:physiology*
D007074:Immunoglobulin G; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin; D003345:Corticosterone