Microemulsions with timolol as potential eye drops.
Stable microemulsions oil-in-water (o/w) and water-in-oil (w/o) with timolol were obtained. These formulations were sterilized using two methods: by autoclaving and by sterile filtering according to the Polish Pharmacopeia V. Microemulsions were kept in the temperatures of 25 degrees C and 5 degrees C during three months. The following physical parameters were investigated: density, dynamic viscosity, refractive index, surface tension, pH and osmotic tension. All the microemulsions met the requirements for eye drops.
Malina
I
I
Department of Pharmaceutical Technology, Karol Marcinkowski University of Medical Sciences, 6, Grunwaldzka Str, 60-780 Poznan, Poland. imalina@amp.edu.pl
Radomska-Soukharev
A
A
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000737:chemistry; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions; D006863:Hydrogen-Ion Concentration; D009883:Ophthalmic Solutions; D009994:Osmolar Concentration; D013242:Sterilization; D013500:Surface Tension; D013999:Timolol / Q000008:administration & dosage* / Q000737:chemistry; D014462:Ultrafiltration; D014783:Viscosity
D000319:Adrenergic beta-Antagonists; D004655:Emulsions; D009883:Ophthalmic Solutions; D013999:Timolol