Stability of andrographolide in powdered Andrographis herb under accelerated conditions.
The stability of andrographolide in powdered Andrographis Herb--the aerial part of Andrographis paniculata (Burm. f.) Nees (Acanthaceae)--was determined using a heat-accelerated experiment to reveal a second-order kinetics of degradation. The fast decomposition was observed regardless of the method of analysis. The rate constant of the decomposition of andrographolide at 25 degrees C ( K(25)( degrees C)), predicted from the Arrhenius plot, was 6.58 x 10 (-6) d (-1).
Plubrukarn
Anuchit
A
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand.
Pinsuwan
Sirirat
S
Ingkatawornwong
Suthimaln
S
Supavita
Tanomjit
T
D035685:Andrographis / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D004355:Drug Stability; D004356:Drug Storage / Q000592:standards; D006358:Hot Temperature; D007700:Kinetics
D004224:Diterpenes; C030419:andrographolide