title: [Blood leptin, orexins and NPY levels and their relations in obese children].
abstract: OBJECTIVE
  To investigate the concentration levels of leptin, orexins and neuropeptide Y (NPY) in the blood of obese children, and to analysed the relationship between these substances.
  
  
  METHODS
  RIA methods were used to measure the concentrations of leptin, orexinA, orexinB, and NPY in the blood of 98 obese children [BMI: male (29.24 +/- 1.87) kg/mZ, female (28.12 +/- 2.30) kg/m2] and in 104 normal children [BMI: male (20.49 +/- 1.95) kg/m2, female (19.59 +/- 1.51) kg/m2] as the control group.
  
  
  RESULTS
  The leptin concentrations in obese children [male (26.00 +/- 14.66) ng/mL; female (33.59 +/- 14.63) ng/mL] were higher than those in the control group [male (6.65 +/- 44.49) ng/mL; female [10.48 +/- 5.52) ng/mL P < 0.013]. The concentrations of plasma orexinA in obes children [male (3.23 +/- 1.86) pg/mL; female (3.38 +/- 1.80) pg/mL] were lower than those in the control group [male (4.52 +/- 1.52) pg/mL; female (4.71 +/- 1.53) pg/mL P < 0.05]; Negative correlations between leptin and NPY were noted in the obesity group (r = -0.302) and the control group (r = -0.310, P < 0.01), while the slopes in the two groups were different (control group -2.969; obese group -0.809). A positive correlation between NPY and orexinA was noted (r = 0.207, P < 0.05). The fluctuation range of orexinA in obese children was markedly narrowed when compared with that in the control group.
  
  
  CONCLUSIONS
  The concentration level of peripheral orexinA and leptin in the obese and non-obese children change inversely. The obesity in children correlates with the concentrations of orexinA, leptin, NPY as well as with their interactions.
authors.affiliation: Department of Envirommental Health, West China School of Public Health, Sichan University, Chengdu 610041, China.
authors.forename: Xiao-min
authors.initials: XM
authors.lastname: Lou
authors.forename: Guang-cai
authors.initials: GC
authors.lastname: Duan
authors.forename: Jiang
authors.initials: J
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qiao-yun
authors.initials: QY
authors.lastname: Hu
authors.forename: Zheng-chang
authors.initials: ZC
authors.lastname: Heng
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000097:blood*; D009478:Neuropeptide Y / Q000097:blood*; D009479:Neuropeptides / Q000097:blood*; D009765:Obesity / Q000097:blood*; D000068797:Orexins
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D009478:Neuropeptide Y; D009479:Neuropeptides; D000068797:Orexins