Modulation of pituitary adenylate cyclase-activating polypeptide (PACAP) expression in explant-cultured guinea pig cardiac neurons.
Pituitary adenylate cyclase-activating polypeptide (PACAP) expression was quantified in explant-cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP-immunoreactive neurons and pro-PACAP transcript levels increased significantly. Treatment with neurturin or glial-derived neurotrophic factor significantly suppressed the percentage of PACAP-IR neurons, but not pro-PACAP transcript levels.
Girard
Beatrice M
BM
University of Vermont College of Medicine, Department of Anatomy & Neurobiology, 149 Beaumont Avenue, HSRF 416A, Burlington, VT 05405, USA. Beatrice.Girard@uvm.edu
Young
Beth A
BA
Buttolph
Thomas R
TR
White
Sheryl L
SL
Parsons
Rodney L
RL
D000818:Animals; D049109:Cell Proliferation; D005260:Female; D005786:Gene Expression Regulation; D006168:Guinea Pigs; D008297:Male; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000235:genetics / Q000378:metabolism*
D051219:Pituitary Adenylate Cyclase-Activating Polypeptide