Lethal acute lung injury and hypoglycemia after subcutaneous administration of monochloroacetic acid.
Hypoglycemia is suspected in the acute lethal toxicity induced by cutaneous exposure to monochloroacetic acid (MCA). Although it has been shown that hepato-renal dysfunction is involved, the mechanism and the target organs that directly affect mortality remain to be determined. We suspected respiratory failure as a main cause of death in some reported cases. We investigated dose-response effects, hypoglycemia, and lung injury in rats exposed to MCA. Serum glucose, blood gases, and parameters of alveolar injury in bronchoalveolar lavage fluid (BALF) were analysed 2 and 4 h after subcutaneous administration of MCA (108, 135 or 163 mg/kg). Apparent pulmonary injury and hypoglycemia were not identified 2 h after administration, but lactate dehydrogenase (LDH) and total cells in BALF were dose-dependently increased; and severe hypoglycemia was identified 4 h after administration. Blood gas analysis showed remarkable alveolar gas dysfunction as exchange in the 163 mg/kg group. Thus, hypoglycemia and lung injury appear to cause death in response to MCA exposure.
Kato
Junko
J
Department of Hygiene and Public Health, Osaka Medical College, 2-7 Daigakumachi, Takatsuki City, Osaka 569-8686, Japan. in1073@poh.osaka-med.ac.jp
Dote
Tomotaro
T
Shimizu
Hiroyasu
H
Shimbo
Yukari
Y
Fujihara
Michiko
M
Kono
Koichi
K
D000085:Acetates / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D002452:Cell Count; D007003:Hypoglycemia / Q000139:chemically induced*; D007279:Injections, Subcutaneous; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007928:Lethal Dose 50; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000085:Acetates; D001786:Blood Glucose; C006972:chloroacetic acid; D007770:L-Lactate Dehydrogenase