title: Area-selective signal parameter estimation for two-dimensional MR spectroscopy data.
abstract: We consider the problem of parametric spectral analysis of two-dimensional (2D) magnetic resonance spectroscopy (MRS) data. Estimating the signal components from 2D MRS data is becoming common practice in many clinical MR applications. The most frequently used signal processing tool for this estimation problem is the non-parametric 2D-FFT. There are several alternative parametric methods available to perform this analysis, yet their computational complexity is generally rather high and it becomes prohibitive when the number of points in the measured data matrix is large. In this paper, we propose a novel signal parameter estimation technique which operates on a pre-specified sub-area of the 2D spectrum. This area-selective approach can be used either to estimate only the signal components of main interest in the data, or to compute signal parameter estimates of all present signal components as the computational burden for each sub-area is low. In the numerical example section we consider both simulated data and in vitro 1H data acquired from a 1.5 T MR scanner.
authors.affiliation: Systems and Control Division, Department of Information Technology, Uppsala University, P.O. Box 337, SE-751 05 Uppsala, Sweden. niclas.sandgren@it.uu.se
authors.forename: Niclas
authors.initials: N
authors.lastname: Sandgren
authors.forename: Petre
authors.initials: P
authors.lastname: Stoica
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Frigo
mesh_terms: D000465:Algorithms; D045424:Complex Mixtures / Q000737:chemistry*; D003198:Computer Simulation; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008958:Models, Molecular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D045424:Complex Mixtures