Bioactive analogs of neurotensin: focus on CNS effects.
Neurotensin (NT) is a 13-amino acid neuropeptide found in the central nervous system and in the gastrointestinal tract. It is closely associated anatomically with dopaminergic and other neurotransmitter systems, and evidence supports a role for NT agonists in the treatment of various neuropsychiatric disorders. However, NT is readily degraded by peptidases, so there is much interest in the development of stable NT agonists, that can be injected systemically, cross the blood-brain barrier (BBB), yet retains the pharmacological characteristics of native NT for therapeutic use in the treatment of diseases such as schizophrenia, Parkinson's disease and addiction.
Boules
Mona
M
Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. boules.mona@mayo.edu
Fredrickson
Paul
P
Richelson
Elliott
E
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D013287:Illicit Drugs; D009496:Neurotensin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000503:physiopathology; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology; D018028:Receptors, Neurotensin / Q000819:agonists / Q000187:drug effects / Q000502:physiology
D014150:Antipsychotic Agents; D013287:Illicit Drugs; D010908:Pituitary Hormones, Anterior; D011619:Psychotropic Drugs; D018028:Receptors, Neurotensin; D009496:Neurotensin; D004298:Dopamine