title: Phenolic glycosides from Exostema mexicanum leaves.
abstract: Phytochemical investigation of the leaves of Exostema mexicanum led to the isolation of two novel acylated flavonol glycosides 6, 7 and three glycosides 1-4 structurally belonging to the group of 4-phenylcoumarins. One of them, 5-O-beta-D-glucopyranosyl-4'-hydroxy-7-methoxy-4-phenylcoumarin (2), turned out to be new. Furthermore, the 4-phenylcoumarin aglycone 3'-hydroxy-4',5,7-trimethoxy-4-phenylcoumarin (5) was obtained. The in vitro cytotoxicity of 3-5 against the cell line ECV-304 was evaluated; the aglycone 5 was highly cytotoxic, whereas the glycosidic compounds 3 and 4 were inactive.
authors.affiliation: Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Froelich
authors.forename: K
authors.initials: K
authors.lastname: Siems
authors.forename: M A
authors.initials: MA
authors.lastname: Hernández
authors.forename: R A
authors.initials: RA
authors.lastname: Ibarra
authors.forename: W G
authors.initials: WG
authors.lastname: Berendsohn
authors.forename: K
authors.initials: K
authors.lastname: Jenett-Siems
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002855:Chromatography, Thin Layer; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008800:Mexico; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010636:Phenols; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue