Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida.
A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides were isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida. The structures of the compounds were determined to be cimilactone A (1), 25-O-acetylcimigenol 3-O-beta-d-xylopyranoside (2) and cimigenol 3-O-alpha-l-arabinopyranoside (3), respectively, using spectroscopic analysis. The three compounds were examined for their anticomplement activity against the classical pathway of the complement system. Compound 1 showed significant anticomplement activity with an IC(50) value of 28.6 microm, whereas compounds 2 and 3 were inactive.
Qiu
Minghua
M
Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, People's Republic of China.
Kim
Jung-Hee
JH
Lee
Hyeong-Kyu
HK
Min
Byung-Sun
BS
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D031885:Cimicifuga / Q000737:chemistry*; D051056:Complement Inactivating Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003171:Complement Pathway, Classical / Q000187:drug effects*; D005419:Flavonoids; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry; D012756:Sheep; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C506863:25-O-acetylcimigenol-3-O-beta-D-xylopyranoside; D001578:Benzopyrans; D051056:Complement Inactivating Agents; D005419:Flavonoids; D006027:Glycosides; D007783:Lactones; D010936:Plant Extracts; D014315:Triterpenes; C516497:cimigenol 3-O-alpha-L-arabinopyranoside; C468590:cimilactone A; C052083:tiliroside; D000432:Methanol