Analysis of epistasis for diabetic nephropathy among type 2 diabetic patients.
Diabetic nephropathy (DN) is one of the most serious complications of diabetes, accounting for the majority of patients with end-stage renal disease. The molecular pathogenesis of DN involves multiple pathways in a complex, partially resolved manner. The paper presents an exploratory epistatic study for DN. Association analysis were performed on 231 SNP loci in a cohort of 264 type 2 diabetes patients, followed by the epistasis analysis using the multifactor dimensionality reduction and the genetic algorithm with Boolean algebra. A two-locus epistatic effect of EGFR and RXRG was identified, with a cross-validation consistency of 91.7%.
Hsieh
Chang-Hsun
CH
Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan.
Liang
Kung-Hao
KH
Hung
Yi-Jen
YJ
Huang
Li-Chin
LC
Pei
Dee
D
Liao
Ya-Tang
YT
Kuo
Shi-Wen
SW
Bey
Monica Shian-Jy
MS
Chen
Jui-Lin
JL
Chen
Ellson Y
EY
D000368:Aged; D000465:Algorithms; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000209:etiology / Q000235:genetics*; D004843:Epistasis, Genetic; D005260:Female; D018773:Genes, erbB-1; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D047491:Retinoid X Receptor gamma / Q000235:genetics; D013624:Taiwan
D047491:Retinoid X Receptor gamma