title: Giant hepatic adenoma with bone marrow metaplasia not associated with oral contraceptive intake.
abstract: BACKGROUND
  Hepatocellular adenomas are the most common benign liver tumors. They are usually related to oral contraceptive intake.
  
  
  METHODS
  This case describes a 58-year-old woman admitted to our institution for a hepatic mass incidentally discovered during a routine examination. The patient, who was never on oral contraceptives, was asymptomatic upon admission. She underwent a thorough diagnostic evaluation and then a hepatic right trisegmentectomy. The histologic evaluation of the mass showed that it was a hepatocellular adenoma with areas of bone marrow metaplasia.
  
  
  CONCLUSIONS
  Bone marrow metaplasia has rarely been found associated to liver tumors. The presence of marrow-derived hepatic progenitor cells might be the source of both adenoma hepatocytes and bone marrow differentiated cells. To our knowledge, this is only the second case in the English literature in which areas of bone marrow metaplasia were found in a hepatocellular adenoma.
authors.affiliation: Hepatobiliary-pancreatic Surgery, Department of Surgery, University of Rome La Sapienza, II School of Medicine, St, Andrea Hospital, Rome, Italy. giovanni.ramacciato@uniroma1.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ramacciato
authors.forename: Giuseppe R
authors.initials: GR
authors.lastname: Nigri
authors.forename: Paolo
authors.initials: P
authors.lastname: Aurello
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Angelo
authors.forename: Francesca
authors.initials: F
authors.lastname: Pezzoli
authors.forename: Simone
authors.initials: S
authors.lastname: Rossi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Pilozzi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ercolani
authors.forename: Matteo
authors.initials: M
authors.lastname: Ravaioli