Zygomycosis in the immunocompromised patient: a case report.
Zygomycosis is a highly aggressive infection observed in immunocompromised patients, such as those with haematological malignancies. The sites most frequently involved are the sinuses and the lungs. New diagnostic tools and new antifungal treatments are essential in order to diagnose early and treat efficiently infections due to moulds. We report a case of sinusitis due to Absidia corymbifera occurring during chemotherapy-induced bone marrow aplasia in a patient with acute leukaemia. The sinusitis was successfully treated with AmBisome, and surgical debridement.
Georgala
Aspasia
A
Infectious Disease Department, Jules Bordet Institute, Brussels, Belgium. nathalie.cardinal@bordet.be
Vekemans
Marc
M
Husson
Mireille
M
Meuleman
Nathalie
N
Beguin
Hugues
H
Nolard
Nicole
N
Aoun
Mickael
M
D020095:Absidia / Q000302:isolation & purification*; D000208:Acute Disease; D000336:Aerosols; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000677:Amsacrine / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D003646:Debridement; D025141:Drug Resistance, Fungal; D019008:Drug Resistance, Neoplasm; D005047:Etoposide / Q000008:administration & dosage; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007938:Leukemia / Q000150:complications / Q000188:drug therapy; D008081:Liposomes; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000336:Aerosols; D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000677:Amsacrine; D003561:Cytarabine; D005047:Etoposide; D000666:Amphotericin B; D015725:Fluconazole; D003630:Daunorubicin