title: Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome.
abstract: Eight different batches of intravenous immunoglobulin from 3 different manufacturers were tested for neutralizing activities against all currently known streptococcal superantigens. Statistically significant variation among different intravenous immunoglobulin preparations (P<.0001) and between individual streptococcal superantigens (P<.0001) was observed. These results might be helpful for optimizing the type and dose of intravenous immunoglobulin used in adjunctive therapy for severe invasive streptococcal disease.
authors.affiliation: Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. t.proft@auckland.ac.nz.
authors.forename: Birgit
authors.initials: B
authors.lastname: Schrage
authors.forename: Guowen
authors.initials: G
authors.lastname: Duan
authors.forename: Lily P
authors.initials: LP
authors.lastname: Yang
authors.forename: John D
authors.initials: JD
authors.lastname: Fraser
authors.forename: Thomas
authors.initials: T
authors.lastname: Proft
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000276:immunology / Q000592:standards* / Q000627:therapeutic use; D009500:Neutralization Tests; D012772:Shock, Septic / Q000188:drug therapy*; D013290:Streptococcal Infections / Q000188:drug therapy*; D013291:Streptococcus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D016756:Immunoglobulins, Intravenous; D018089:Superantigens