title: SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton.
abstract: The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.
authors.affiliation: Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.
authors.forename: Yonatan B
authors.initials: YB
authors.lastname: Tzur
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Wilson
authors.forename: Yosef
authors.initials: Y
authors.lastname: Gruenbaum
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism / Q000502:physiology*; D005544:Forecasting; D008954:Models, Biological; D009685:Nuclear Envelope / Q000737:chemistry / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D010802:Phylogeny; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology
chemical_list: D009687:Nuclear Proteins