title: [Sentinel lymph node biopsy for in situ carcinoma of the breast. Experience at the Bács-Kiskun County Hospital and review of the literature].
abstract: Sentinel node biopsy (SNB) is controversial for in situ breast cancers. We reviewed our experience with in situ and microinvasive carcinomas and surveyed the literature.
  
  
  METHODS
  SNB was performed with intraparenchymal administration of vital dye alone or combined with radiocolloid. The SNs were assessed histologically with haematoxylin eosin staining and cytokeratin immunohistochemistry.
  
  
  RESULTS
  Patients with in situ (36) or microinvasive (20) carcinomas underwent SNB: 59 axillary and 1 parasternal, and 39 axillary and 1 parasternal SNs were recovered, respectively. The SNs were positive in 4 patients and 1 patient, respectively: 1 micrometastasis and 3 isolated tumour cells, and 1 micrometastasis in the respective groups. No further axillary nodes were found positive after dissection. Further 21 invasive carcinomas (often with extensive intraductal component) had an in situ carcinoma diagnosis preoperatively: of 39 axillary and 3 parasternal SNs 10 patients had nodal involvement in 13 axillary SNs; 5 patients also had further lymph nodes involved after dissection.
  
  
  CONCLUSIONS
  The definitive diagnosis of in situ carcinoma does not warrant SNB. This procedure should be considered if the tumour is to be removed by mastectomy, or if the diagnosis is preoperative and there are associated high-risk factors for the subsequent diagnosis of invasive cancer.
authors.affiliation: Bács-Kiskun Megyei Onkormányzat Kórháza, Patológiai Osztály. cserni@freemail.hu
authors.forename: Gábor
authors.initials: G
authors.lastname: Cserni
authors.forename: Gábor
authors.initials: G
authors.lastname: Boross
authors.forename: Róbert
authors.initials: R
authors.lastname: Maráz
authors.forename: Mária
authors.initials: M
authors.lastname: Rajtár
authors.forename: Eva
authors.initials: E
authors.lastname: Ambrózay
authors.forename: Rita
authors.initials: R
authors.lastname: Bori
authors.forename: Mária
authors.initials: M
authors.lastname: Sinkó
authors.forename: Mihály
authors.initials: M
authors.lastname: Svébis
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006766:Hospitals, County; D006801:Humans; D006814:Hungary; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C083602:technetium Tc 99m nanocolloid