Age-related changes in activity of enzymes catalyzing oxidation-reduction of endogenous aldehydes in the liver of rats during immobilization stress.
Activities of aldehyde dehydrogenase and aldehyde reductase in the liver 1.5-, 12-, and 24-month-old rats were measured after 30-min immobilization. Changes in activities of aldehyde dehydrogenase and aldehyde reductase in the liver after immobilization stress depended on animal age. These shifts lead to a strain in endogenous aldehyde utilization in the aldehyde reductase reaction in 1.5-month-old animals and inhibition of utilization of these metabolites in oxidation-reduction reactions in 24-month-old rats.
Davydov
V V
VV
Laboratory of Age-Specific Endocrinology and Metabolism, Institute of Child and Adolescent Health Protection, Academy of Medical Sciences, Kharkov. dav@nord.vostok.net
Fomina
E V
EV
D000367:Age Factors; D000444:Aldehyde Dehydrogenase / Q000032:analysis*; D000449:Aldehyde Reductase / Q000032:analysis*; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D002384:Catalysis; D007103:Immobilization; D008099:Liver / Q000201:enzymology*; D008110:Liver Extracts; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000201:enzymology*
D000447:Aldehydes; D008110:Liver Extracts; D000449:Aldehyde Reductase; D000444:Aldehyde Dehydrogenase