title: The role of tetrahydrobiopterin in catalysis by nitric oxide synthase.
abstract: Electronic structure calculations show that the cofactor H4B can be a key factor in a proton transfer relay in nitric oxide synthase, and that 4-amino-H4B cannot fulfill this role.
authors.affiliation: School of Chemistry, University of Manchester, Manchester, UK.
authors.forename: Inaki
authors.initials: I
authors.lastname: Morao
authors.forename: Ganga
authors.initials: G
authors.lastname: Periyasamy
authors.forename: Ian H
authors.initials: IH
authors.lastname: Hillier
authors.forename: John A
authors.initials: JA
authors.lastname: Joule
mesh_terms: D000465:Algorithms; D001120:Arginine / Q000378:metabolism; D001665:Binding Sites; D001708:Biopterins / Q000031:analogs & derivatives* / Q000494:pharmacology; D002384:Catalysis; D004579:Electron Transport; D006418:Heme / Q000378:metabolism; D015394:Molecular Structure; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D011522:Protons
chemical_list: D011522:Protons; D001708:Biopterins; D006418:Heme; D001120:Arginine; D019001:Nitric Oxide Synthase; C003402:sapropterin