title: A patient with severe, recurrent hypoglycemia and glycemic lability who underwent islet transplantation.
abstract: BACKGROUND
  A 48-year-old woman who was diagnosed with type 1 diabetes at 5 years of age presented to our Clinical Islet Transplant Program with severe, recurrent hypoglycemia and glycemic lability. She was diligent with her diet, used a continuous subcutaneous insulin infusion pump (32 U per day), and monitored her glucose levels typically eight times a day. The patient usually had one hypoglycemic reaction a day, experienced a severe reaction once a month, and had marked variability of her glucose values. On presentation, her HYPO score was 584 and her lability index was 868 mmol/l(2)/h per week.
  
  
  METHODS
  HYPO score, lability index score, screening for diabetes complications, and routine pretransplant evaluation.
  
  
  METHODS
  Severe, recurrent hypoglycemia and glycemic lability associated with type 1 diabetes.
  
  
  RESULTS
  The patient underwent islet transplantation. Post-transplant, the problems with hypoglycemia abated and excellent stable glycemic control was attained, although some side effects from the immunosuppressive drug, sirolimus, were evident. Insulin was reinstituted 2.5 years after surgery, at lower doses than before the transplant because of deterioration in graft function. Occasional episodes of hypoglycemia have occurred and some glycemic lability has recurred, although endogenous insulin secretion is still preserved.
authors.affiliation: Clinical Islet Transplant Program, AB Canada. edmond.ryan@ualberta.ca
authors.forename: Edmond A
authors.initials: EA
authors.lastname: Ryan
authors.forename: Am James
authors.initials: AJ
authors.lastname: Shapiro
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015190:Blood Glucose Self-Monitoring; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000150:complications / Q000517:prevention & control*; D016381:Islets of Langerhans Transplantation; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose