Cigarette smoke causes small airway remodeling by direct growth factor induction and release.
Churg
Andrew
A
Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC Canada V6T 2B5. achurg@interchange.ubc.ca
Wang
Rong D
RD
Wright
Joanne L
JL
D000818:Animals; D016084:Bronchoconstriction; D002478:Cells, Cultured; D055513:Connective Tissue Growth Factor; D006801:Humans; D017874:Immediate-Early Proteins / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D051381:Rats; D020545:Respiratory Mucosa / Q000378:metabolism / Q000473:pathology*; D012907:Smoking / Q000009:adverse effects / Q000378:metabolism / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology*; D000509:alpha-Fetoproteins / Q000494:pharmacology
C526317:CCN2 protein, human; C526316:CCN2 protein, rat; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D053773:Transforming Growth Factor beta1; D000509:alpha-Fetoproteins; D055513:Connective Tissue Growth Factor