title: Cell biology: nondisjunction, aneuploidy and tetraploidy.
abstract: One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction--a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King challenge this view, concluding that nondisjunction does not yield aneuploid cells directly, but instead gives rise to tetraploid cells that may subsequently become aneuploid through further division. Here we show that the direct result of chromosome nondisjunction is gain or loss of a single chromosome, which results in near-diploid aneuploidy, not tetraploidy. We suggest that chromatin trapped in the cytokinetic cleavage furrow is the more likely reason for furrow regression and tetraploidization.
authors.affiliation: Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093-0670, USA.
authors.forename: Beth A A
authors.initials: BA
authors.lastname: Weaver
authors.forename: Alain D
authors.initials: AD
authors.lastname: Silk
authors.forename: Don W
authors.initials: DW
authors.lastname: Cleveland
mesh_terms: D000782:Aneuploidy; D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D048749:Cytokinesis; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008957:Models, Genetic; D009630:Nondisjunction, Genetic / Q000235:genetics* / Q000502:physiology*; D011123:Polyploidy; D015203:Reproducibility of Results
chemical_list: D002868:Chromosomal Proteins, Non-Histone; C068688:centromere protein E