IL-1 gene polymorphism and periodontal status of HIV Brazilians on highly active antiretroviral therapy.
A genotype in the IL-1 gene cluster is associated with an increased risk of periodontitis. We investigated whether polymorphisms in the IL-1A +4845 and IL-1B +3954 loci affect the periodontal status of HIV-infected Brazilians on HAART. HIV-positive and HIV-negative subjects with periodontitis were genotyped for IL-1 by polymerase chain reaction and restriction enzyme digestion. Only 11.4% of patients were genotype positive. No associations between genotype positivity and HIV infection or periodontal status were found in this population.
Gonçalves
Lucio de S
LS
Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Ferreira
Sônia Maria S
SM
Souza
Celso O
CO
Colombo
Ana Paula V
AP
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001938:Brazil; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D010518:Periodontitis / Q000139:chemically induced*; D011110:Polymorphism, Genetic / Q000235:genetics*
D007375:Interleukin-1