Cerebroprotective effect of a new taurine derivative during cerebral ischemia.
A new taurine derivative chlorohydrate-N-isopropylamide-2-(1-phenylethyl)aminoethanesulfonic acid normalized energy metabolism, inhibited lipid peroxidation, and reactivated antioxidant enzymes in the brain of rats exposed to ischemia. This taurine derivative decreased the mortality rate of animals with ischemic changes in cerebral circulation. The test compound was more potent than piracetam in producing the cerebroprotective effect.
Sapronov
N S
NS
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St Petersburg.
Bul'on
V V
VV
Krylova
I B
IB
Gavrovskaya
L K
LK
Selina
E N
EN
Evdokimova
N R
NR
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D004734:Energy Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013654:Taurine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
D018696:Neuroprotective Agents; C513706:chlorohydrate-N-isopropylamide-2-(1-phenylethyl)aminoethanesulfonic acid; D013654:Taurine