title: [Severe anaphylaxis from rocuronium].
abstract: Muscle relaxant drugs are the most frequent cause of anaphylactic and anaphylactoid reactions during anaesthesia. We report a case of a life-threatening anaphylactic reaction during induction of anaesthesia with severe bronchospasm as the first clinical symptom. Mechanical ventilation was nearly impossible. The patient required a multimodal antiallergic therapy and a high-dose catecholamine therapy for stabilization. Rocuronium was identified as the allergic agent using intradermal testing.
authors.affiliation: Zentrum für Anästhesiologie und Intensivmedizin, Universitätsklinikum, Martinistrasse 52, 20246 Hamburg-Eppendorf. jkubitz@gmx.de
authors.forename: J C
authors.initials: JC
authors.lastname: Kubitz
authors.forename: T
authors.initials: T
authors.lastname: Krause
authors.forename: R
authors.initials: R
authors.lastname: Dietz
authors.forename: P
authors.initials: P
authors.lastname: Friederich
authors.forename: A E
authors.initials: AE
authors.lastname: Goetz
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D000732:Androstanols / Q000009:adverse effects*; D000758:Anesthesia; D001986:Bronchial Spasm / Q000139:chemically induced / Q000503:physiopathology; D002395:Catecholamines / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D012121:Respiration, Artificial; D000077123:Rocuronium; D012867:Skin / Q000473:pathology; D012882:Skin Tests
chemical_list: D000732:Androstanols; D002395:Catecholamines; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium