[Studies on the association between beta 2-glycoprotein I and hepatotropism of hepatitis B virus].
OBJECTIVE
To further study the binding character of hepatitis B surface antigen (HBsAg) and beta 2-glycoprotein I (beta2GP I) and to explore whether beta2GP I plays an important role in the hepatotropism of hepatitis B virus.


METHODS
Using Western blot technique, we observed the binding character of the HBsAg with reduced and non-reduced beta2GP I.


RESULTS
rHBsAgs with reduced and non-reduced beta2GP I showed identical binding activity.


CONCLUSIONS
The binding activity of HBsAg is dependent on tandem residues, but not on conformational structures of beta2GP I. There is a specific binding between HBV and beta2GP I, which may play an important role in HBV infection and is one of the reasons of hepatotropism of HBV.
Gao
Yan-hang
YH
Department of Gastroenterology, First Hospital, Jilin University, Changchun 130021, China.
Gao
Pu-jun
PJ
Wang
Dan
D
Shi
Yang
Y
Tang
Tong-yu
TY
Piao
Yun-feng
YF
Yang
Han-yi
HY
D006509:Hepatitis B / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D014759:Viral Envelope Proteins / Q000097:blood; D053482:beta 2-Glycoprotein I / Q000097:blood*
D006514:Hepatitis B Surface Antigens; D014759:Viral Envelope Proteins; D053482:beta 2-Glycoprotein I