[Lanthanides and microanalysis. Effects of oral administration of two lanthanides: ultrastructural and microanalytical study].
The subcellular localization of cerium and lanthanum in the intestinal mucosa was studied after oral administration of cerium chloride or lanthanum chloride or lanthanum chloride followed 30 minutes after of cerium chloride to young adults Wistar rats. Two methods of observation and microanalysis were used. The transmission electron microscopy revealed the presence of dense electron granulations in the lysosmes of the duodenum enterocyte, when these elements were administrated simultaneously. The ion mass microanalysis permits to detect the presence of La and Ce as bright points outlining the intestinal villi. These points correspond to the lysosomes containing the granulations previously described. These granulations are formed by the cerium and the lanthanum associated to the phosphor and forming probably insoluble salts of Ce/La phosphate.
Fehri
E
E
Laboratoire de physiologie, Faculté de Médecine de Tunis.
Ayadi
A
A
Boubaker
S
S
Karray
S
S
Jaafoura
H
H
El Hili
A
A
Galle
P
P
Tekaya
L
L
D000284:Administration, Oral; D000818:Animals; D002563:Cerium / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D004353:Drug Evaluation, Preclinical; D004386:Duodenum / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure; D004577:Electron Probe Microanalysis; D020895:Enterocytes / Q000737:chemistry / Q000187:drug effects / Q000648:ultrastructure; D006097:Granulation Tissue / Q000737:chemistry / Q000187:drug effects / Q000648:ultrastructure; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure; D007811:Lanthanum / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D008247:Lysosomes / Q000737:chemistry / Q000187:drug effects / Q000648:ultrastructure; D017348:Microscopy, Electron, Scanning Transmission; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D013997:Time Factors
D012996:Solutions; C028521:lanthanum chloride; D002563:Cerium; D007811:Lanthanum