title: Systemic and brain metabolic dysfunction as a new paradigm for approaching Alzheimer's dementia.
abstract: Since its definition Alzheimer's disease has been at the centre of consideration for neurologists, psychiatrists, and pathologists. With John P. Blass it has been disclosed a different approach Alzheimer's disease neurodegeneration understanding not only by the means of neurochemistry but also biochemistry opening new scenarios in the direction of a metabolic system degeneration. Nowadays, the understanding of the role of cholesterol, insulin, and adipokines among the others in Alzheimer's disease etiopathogenesis is clarifying approaches valuable not only in preventing the disease but also for its therapy.
authors.affiliation: Scientific Department, Sigma-Tau, Via Pontina km 30,400, Pomezia, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Giordano
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Peluso
authors.forename: Maurizio
authors.initials: M
authors.lastname: Iannuccelli
authors.forename: Paola
authors.initials: P
authors.lastname: Benatti
authors.forename: Raffaella
authors.initials: R
authors.lastname: Nicolai
authors.forename: Menotti
authors.initials: M
authors.lastname: Calvani
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000544:Alzheimer Disease / Q000266:history* / Q000378:metabolism* / Q000523:psychology; D001057:Apolipoproteins E / Q000378:metabolism; D001923:Brain Chemistry / Q000502:physiology*; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D054439:Ghrelin; D049673:History, 20th Century; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism*; D008875:Middle Aged; D036361:Peptide Hormones / Q000378:metabolism
chemical_list: D052242:Adiponectin; D001057:Apolipoproteins E; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D036361:Peptide Hormones; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol