Structure elucidation of fungal sespendole, an inhibitor of lipid droplet synthesis in macrophages.
A new fungal metabolite named sespendole was isolated as an inhibitor of lipid droplet synthesis in mouse macrophages from the culture broth of the fungal strain Pseudobotrytis terrestris FKA-25. The structure and stereochemistry of sespendole were elucidated by spectroscopic studies including various NMR spectral analyses, exciton chirality experiments and the modified Mosher method. Sespendole was found to possess a new indolosesquiterpene skeleton modified with two isoprenes.
Uchida
Ryuji
R
School of Pharmacy, Kitasato University, Tokyo, Japan.
Kim
Yong-Pil
YP
Nagamitsu
Tohru
T
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000818:Animals; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D050356:Lipid Metabolism / Q000187:drug effects*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008968:Molecular Conformation
D004224:Diterpenes; D007211:Indoles; C510263:sespendole