title: [Significance of angiogenesis in malignant tumors].
abstract: Angiogenesis, i.e. development of new vessels from preexisting ones, plays a key role in the development and progression of malignant tumors. Increased angiogenesis is the hallmark of virtully all types of cancer and has been identified as an independent adverse prognostic factor in various solid tumors and hematological malignancies. This review summarizes current knowledge about angiogenic process, describes methods of angiogenesis assessment and appreciates antiangiogenic therapy which offers new and perspective options in the treatment of malignancies.
authors.affiliation: Univerzita Karlova v Praze, Lékafski fakulta a Fakultni nemocnice v Hradci Králové: II. interni klinika, Oddĕleni klinické hematologie. smolej@seznam.cz
authors.forename: Lukás
authors.initials: L
authors.lastname: Smolej
authors.forename: Petra
authors.initials: P
authors.lastname: Beneová
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D020533:Angiogenesis Inhibitors