title: Is the osmotically inactive sodium storage pool fixed or variable?
abstract: Recently, there is renewed interest in the role of osmotically inactive Na(+) storage during Na(+) retention. Although it is well accepted that a portion of the total exchangeable Na(+) reservoir is osmotically inactive, there is current controversy as to whether the osmotically inactive Na(+) storage pool is fixed or variable during Na(+) retention. In this article, we analyze the current scientific evidence to assess whether the osmotically inactive Na(+) storage pool can be dynamically regulated. Our analysis supports the assertion that the osmotically inactive Na(+) storage pool is fixed rather than variable.
authors.affiliation: Division of Nephrology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave., Rm. 7-155 Factor Bldg., Los Angeles, CA 90095, USA. mtnguyen@mednet.ucla.edu
authors.forename: Minhtri K
authors.initials: MK
authors.lastname: Nguyen
authors.forename: Ira
authors.initials: I
authors.lastname: Kurtz
mesh_terms: D000818:Animals; D004285:Dogs; D006801:Humans; D009995:Osmosis / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D012964:Sodium; D011188:Potassium