Expedient synthesis of substituted (S)-N-(alpha-methylbenzyl)aziridines.
We report for the first time that after O-acylation the conjugate addition products of (S)-N-(alpha-methylbenzyl)hydroxylamine undergo an efficient diastereoselective 3-exo-tet ring-closure reaction affording 2- and 2,3-disubstituted-N-alkylaziridines in good to excellent yields.
Bew
Sean P
SP
School of Chemical Sciences & Pharmacy, University of East Anglia, Norwich, Norfolk, UK. s.bew@uea.ac.uk
Hughes
David L
DL
Savic
Vladimir
V
Soapi
Katy M
KM
Wilson
Martin A
MA