title: Similar pattern of diastolic function adaptation of both ventricles to programmed atrioventricular interval modification in patients with DDD pacing.
abstract: OBJECTIVE
  To evaluate both left ventricular (LV) and right ventricular (RV) diastolic performance adaptation to variable atrioventricular interval (AVI), in patients with DDD pacing for complete heart block and to investigate a possible interaction between LV and RV in this specific cohort of patients.
  
  
  METHODS
  We studied 22 consecutive patients (mean age 65.2 +/- 14.3 years) who underwent DDD pacemaker implantation following admission for complete heart block. One day following implantation, patients were paced at 3 different pacing modes, under the same programmed heart rate and a different AVI (100, 150 and 200 ms respectively). Standard Doppler echocardiography of mitral and tricuspid valve inflow was performed to evaluate LV and RV diastolic function, during each pacing mode.
  
  
  RESULTS
  Left ventricular and RV diastolic performance adaptation to variable AVI modifications was similar, showing a progressive increase of late diastolic filling velocities and a subsequent decrease of E/A wave ratios following AVI prolongation. A short AVI of 100 or 150 ms was associated with improved LV and RV diastolic filling dynamics.
  
  
  CONCLUSIONS
  In elderly patients with complete heart block and unimpaired systolic function undergoing DDD pacemaker implantation, both ventricles share a similar pattern of diastolic function adaptation to AVI modifications and that might be the reflection of ventricular interaction under this specific pacing mode.
authors.affiliation: 1st Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece.
authors.forename: Ioannis H
authors.initials: IH
authors.lastname: Styliadis
authors.forename: Christodoulos E
authors.initials: CE
authors.lastname: Papadopoulos
authors.forename: Nikolaos I
authors.initials: NI
authors.lastname: Gouzoumas
authors.forename: Georgios
authors.initials: G
authors.lastname: Giannakoulas
authors.forename: Haralambos I
authors.initials: HI
authors.lastname: Karvounis
authors.forename: Mihail
authors.initials: M
authors.lastname: Karamouzis
authors.forename: Amalia
authors.initials: A
authors.lastname: Boufidou
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Parharidis
mesh_terms: D000222:Adaptation, Physiological; D000368:Aged; D001283:Atrioventricular Node / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006327:Heart Block / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D018497:Ventricular Dysfunction, Right / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right