title: Antifungal susceptibility of Cryptococcus neoformans to amphotericin B and fluconazole.
abstract: Cryptococcus neoformans has emerged as an important opportunistic fungal pathogen in immunocompromised individuals. The therapeutic options of C. neoformans an opportunistic fungal pathogen include flucytosine, amphotericin B, and azole agents. However in the present scenario, emergence of resistance has been reported, hence this study was undertaken to evaluate antifungal susceptibility pattern of C. neoformans isolates from this southern part of India. Ten isolates of C. neoformans were tested against Amp B and fluconazole, of which 7 were susceptible to both and a single isolate of C. neoformans var gatti was resistant to both with MIC of 32mg/ml and 64mg/ml respectively.
authors.affiliation: Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
authors.forename: Annie B
authors.initials: AB
authors.lastname: Khyriem
authors.forename: S
authors.initials: S
authors.lastname: Sujatha
authors.forename: S C
authors.initials: SC
authors.lastname: Parija
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000302:isolation & purification; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007194:India; D016919:Meningitis, Cryptococcal / Q000188:drug therapy / Q000382:microbiology; D009894:Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole