Fulminant hepatic failure caused by Salmonella paratyphi A infection.
We report a case of fulminant hepatic failure associated with Salmonella paratyphi A infection, in a 29-year-old patient who was admitted to the intensive care unit (ICU) with fever of two days, headache and vomiting followed by behavioural changes and disorientation. On examination, the patient appeared acutely ill, agitated, confused, and deeply jaundiced. Temperature 38.5 degrees of C, pulse 92/min, blood pressure 130/89 mmHg. Both samples of blood grew S. paratyphi A, which was sensitive to ceftriaxone and ciprofloxacin. Ceftriaxon was administered with high-dose dexamethasone. Two weeks after treatment with ceftriaxon, the patient was discharged in satisfactory condition.
Khan
Fahmi Yousef
FY
Department of Medicine, Hamad General Hospital, PO Box 3050, Doha, Qatar. fakhanqal@yahoo.co.uk
Kamha
Ahmed A
AA
Alomary
Ibrahim Y
IY
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D017114:Liver Failure, Acute / Q000382:microbiology*; D008297:Male; D010284:Paratyphoid Fever / Q000150:complications* / Q000473:pathology*; D012482:Salmonella paratyphi A / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005938:Glucocorticoids; D002939:Ciprofloxacin; D002443:Ceftriaxone; D003907:Dexamethasone