title: [Bone marrow necrosis as an initial manifestation of Philadelphia chromosome and myeloid antigens positive B acute lymphoblastic leukemia--a case report].
abstract: Many diseases cause bone marrow necrosis (BMN), especially lymphocytic leukemia. To explore the complexity of the pathogenesis and pathology of BMN and understand the multiplicity of clinical features, a case of Philadelphia chromosome positive (Ph+) B acute lymphoblastic leukemia (ALL) expressing myeloid antigens was reported. The results indicated that the clinical features of this case were complicated and multiplex, the diagnosis was confirmed by using bone marrow smear and biopsy, immunophenotype analysis, conventional cytogenetics and fluorescence in situ hybridization (FISH), the prognosis of patients improved by active treatment for primary disease. In conclusion, the Ph+ B ALL expressing myeloid antigen with BMN is very rare, its diagnosis should be confirmed by using multiple methods, and the active treatments should be performed.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Ru-Feng
authors.initials: RF
authors.lastname: Lin
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Lu
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Wu
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Qiu
authors.forename: Bing
authors.initials: B
authors.lastname: Xiao
authors.forename: Jian-Fu
authors.initials: JF
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000097:blood*; D001853:Bone Marrow / Q000473:pathology*; D001855:Bone Marrow Diseases / Q000209:etiology; D002051:Burkitt Lymphoma / Q000150:complications / Q000235:genetics* / Q000276:immunology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D009336:Necrosis / Q000209:etiology; D010677:Philadelphia Chromosome
chemical_list: D000951:Antigens, Neoplasm