Type 1 diabetes mellitus as a polygenic multifactorial disease: immunopathogenic mechanisms of beta-cell destruction.
Dotta
Francesco
F
Diabetes Unit, Dept. of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, University of Siena, Italy. fradotta@tin.it
Fondelli
Cecilia
C
Di Mario
Umberto
U
D000818:Animals; D000917:Antibody Formation; D017209:Apoptosis / Q000502:physiology; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology*; D051379:Mice; D016688:Mice, Inbred NOD; D020412:Multifactorial Inheritance; D018121:Receptors, Cytokine / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D016207:Cytokines; D018121:Receptors, Cytokine