[Change of oxygen free radical in patients with obstructive sleep apnea hypopnea syndrome after the operation of uvulopalatopharyngoplasty].
OBJECTIVE
To explore the mechanism of multiple organ dysfunction in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) by observing the change of SOD,GSH-PX and MDA after uvulopalatopharyngoplasty (UPPP).


METHODS
Colorimetric method was used to examine both the activity of SOD,GSH-PX and the content of MDA before and one month after UPPP in 30 patients with OSAHS. Thirty healthy people were chosen as normal control.


RESULTS
Before UPPP, the activity of SOD, GSH-PX and the content of MDA were (106.3 +/- 41.2) nmol/L (compared with the control group, P < 0.05), (61.8 +/- 6.5) kU/L (P < 0.05) and (6.27 +/- 1.73) mmol/L (P < 0.05) respectively; yet after the operation, the results were(128.5 +/- 33.1) nmol/L (compared with the control group, P > 0.05), (64.6 +/- 6.1) kU/L (P > 0.05) and (1.32 +/- 0.58) mmol/L (P > 0.05).


CONCLUSIONS
The metabolism of oxygen free radical was badly imbalanced in patients with OSAHS, yet one month after UPPP, it was recovered to normal. This suggested that the metabolism imbalance of oxygen free radical was contributed to multiple organ dysfunction in such patients.
Tang
Shuhai
S
Votional Lab of Otolaryngology, P. R. China of Shandong University, Jinan 250012, China. tangsh@sdu.edu.cn
Li
Yanzhong
Y
Wang
Weizhi
W
Wang
Yan
Y
Wang
Xin
X
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures; D010159:Palate / Q000601:surgery; D010614:Pharynx / Q000601:surgery; D011184:Postoperative Period; D017382:Reactive Oxygen Species / Q000378:metabolism*; D020181:Sleep Apnea, Obstructive / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D014609:Uvula / Q000601:surgery
D017382:Reactive Oxygen Species