Polysomy 13 in a canine prostate carcinoma underlining its significance in the development of prostate cancer.
The dog is a well-accepted model for prostate cancer in man because of the striking similarities between both species with respect to the clinical course of the disease as well as to its similar histopathology. Cytogenetic investigations of human prostate cancers has revealed the frequent occurrence of trisomies 7, 8, and 17. In this report, we present a case of prostate carcinoma in a dog characterized by polysomy 13 as the sole cytogenetic abnormality. Along with the known homology between canine chromosome 13 and human chromosome 8 these findings suggest that a homologous area on both chromosomes plays a crucial role in subsets of prostate cancer in both species.
Winkler
Susanne
S
Center for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany.
Reimann-Berg
Nicola
N
Murua Escobar
Hugo
H
Loeschke
Siegfried
S
Eberle
Nina
N
Höinghaus
Ruth
R
Nolte
Ingo
I
Bullerdiek
Jörn
J
D000782:Aneuploidy; D000818:Animals; D004283:Dog Diseases; D004285:Dogs; D007621:Karyotyping; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000662:veterinary*