title: [Class III alcohol dehydrogenase and its role in the human body].
abstract: Class III alcohol dehydrogenase is composed of two chi subunits, encoded by the ADH5 gene and existing in all tissues examined. It possesses a great ability to metabolize long-chain alcohols, while its capacity to oxidize ethanol is very limited. The amino-acid sequence homology and identical structural and kinetic properties indicate that class III alcohol dehydrogenase and formaldehyde dehydrogenase are identical enzymes. ADH III plays a significant role in the metabolism of formaldehyde in the human body.
authors.affiliation: Zakład Diagnostyki Biochemicznej Akademii Medycznej w Białymstoku.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Jelski
authors.forename: Tufik Alizade
authors.initials: TA
authors.lastname: Sani
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002384:Catalysis; D003593:Cytoplasm / Q000378:metabolism; D005557:Formaldehyde / Q000378:metabolism*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007527:Isoenzymes / Q000737:chemistry / Q000502:physiology; D014018:Tissue Distribution
chemical_list: D007527:Isoenzymes; D005557:Formaldehyde; C020145:formaldehyde dehydrogenase (glutathione); D000445:Aldehyde Oxidoreductases