title: Analysis of ultraviolet absorption spectrum of Chinese herbal medicine-Cortex Fraxini by double ANN.
abstract: A fast, accurate and convenient method for the simultaneous determination of multi-component in the Chinese herbal medicine was proposed by using ultraviolet absorption spectrum. In this method, dummy components were added to training sample, and a double artificial neural network (DANN) that has the function of high self-revision and self-simulation was used. Effect of other interference components could be eliminated by adjusting concentration of dummy components. Therefore, the accuracy of concentration prediction for multi-component in the complicated Chinese herbal medicine was improved. It has been realized that two effective components of Cortex Fraxini, aesculin and aesculetin, were simultaneously determined, without any separation. The predicted accuracy was 92% within the permitted relative errors. The measurement precisions of the aesculin and aesculetin were 0.37% and 1.5%, respectively.
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Lifei
authors.initials: L
authors.lastname: Bai
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhang
authors.forename: Hongxia
authors.initials: H
authors.lastname: Wang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Lu
authors.forename: Hanqi
authors.initials: H
authors.lastname: Zhang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
mesh_terms: D000042:Absorption; D031319:Aesculus; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004929:Esculin / Q000032:analysis*; D016571:Neural Networks, Computer; D013056:Spectrophotometry, Ultraviolet / Q000379:methods* / Q000592:standards; D014468:Umbelliferones / Q000032:analysis*
chemical_list: D004365:Drugs, Chinese Herbal; D014468:Umbelliferones; D004929:Esculin; C517354:horse chestnut seed; C007628:esculetin