title: Selenium supplement alleviated the toxic effects of excessive iodine in mice.
abstract: The relationship between the iodine intake level of a population and the occurrence of thyroid diseases is U-shaped. When excessive iodine is ingested, hypothyroidism or hyperthyroidism associated with goiter might develop. The aim of the study was to evaluate the effect of Se supplementation on the depression of type 1 deiodinase (D1) and glutathione peroxidase (GSHPx) activities caused by excessive iodine. D1 activity was assayed by the method with 125I-rT3 as a substrate. Compared to the effect of iodine alone, iodine in combination with selenium increased the activities of D1 and GSHPx. The addition of selenium alleviated the toxic effects of iodine excess on the activities of D1 and GSHPx.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Yang
authors.forename: Huai-Lan
authors.initials: HL
authors.lastname: Guo
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Hou
authors.forename: Lie-Gang
authors.initials: LG
authors.lastname: Liu
authors.forename: Xiu-Fa
authors.initials: XF
authors.lastname: Sun
mesh_terms: D000818:Animals; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D007453:Iodide Peroxidase / Q000378:metabolism; D007455:Iodine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D012643:Selenium / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D014131:Trace Elements / Q000494:pharmacology*
chemical_list: D014131:Trace Elements; D007455:Iodine; D007453:Iodide Peroxidase; D005979:Glutathione Peroxidase; D012643:Selenium