Solventless clay-promoted Friedel-Crafts reaction of indoles with alpha-amido sulfones: unexpected synthesis of 3-(1-arylsulfonylalkyl) indoles.
Friedel-Crafts reaction of indoles with alpha-amido sulfones in the presence of montmorillonite K-10 leads unexpectedly to 3-(1-arylsulfonylalkyl) indoles in good yield. The obtained products can be further desulfonylated under reductive or alkylative conditions giving linear and branched 3-substituted indoles.
Ballini
Roberto
R
Dipartimento di Scienze Chimiche, Università di Camerino, via S. Agostino 1, I-62032 Camerino, Italy.
Palmieri
Alessandro
A
Petrini
Marino
M
Torregiani
Elisabetta
E
D000538:Aluminum Silicates / Q000737:chemistry*; D002384:Catalysis; D000077215:Clay; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013450:Sulfones / Q000737:chemistry*
D000538:Aluminum Silicates; D007211:Indoles; D013450:Sulfones; D000077215:Clay