title: Improvement of atopic dermatitis skin symptoms by Vitreoscilla filiformis bacterial extract.
abstract: Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease. The first line treatment of AD relies on the daily use of emollients to restore the skin barrier impairment associated with the disease. Vitreoscilla filiformis (V.f.) is a non photosynthetic bacterium and extracts of V.f. are endowed with properties which balance cutaneous immune-homeostasis. The aim of our study was to investigate the efficacy and safety of a 5% V.f. extract-containing ointment on mild to moderate AD in a randomised, double-blind, vehicle-controlled trial. Thirteen patients applied the treatment and the vehicle on symmetrical AD lesions (left versus right side of the body) twice daily for 4 weeks. The assessment of AD severity was done at each visit (Day 0, Day 14 and Day 28) using the modified eczema area and severity index (mEASI). Treatment with the ointment containing 5% V.f. extract significantly improved the AD skin symptoms. Beneficial effects were observed after two weeks of treatment and increased thereafter. These results suggest that V.f. extract could be favourably added to AD skin care emollients formulated for AD.
authors.affiliation: L'OREAL Recherche, Clichy, France. agueniche@rd.loreal.com
authors.forename: Audrey
authors.initials: A
authors.lastname: Guéniche
authors.forename: Anca
authors.initials: A
authors.lastname: Hennino
authors.forename: Catherine
authors.initials: C
authors.lastname: Goujon
authors.forename: Karima
authors.initials: K
authors.lastname: Dahel
authors.forename: Philippe
authors.initials: P
authors.lastname: Bastien
authors.forename: Richard
authors.initials: R
authors.lastname: Martin
authors.forename: Roland
authors.initials: R
authors.lastname: Jourdain
authors.forename: Lionel
authors.initials: L
authors.lastname: Breton
mesh_terms: D000293:Adolescent; D000328:Adult; D045424:Complex Mixtures / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D012074:Remission Induction; D012720:Severity of Illness Index; D020589:Vitreoscilla
chemical_list: D045424:Complex Mixtures