title: Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia.
abstract: Fanconi anemia (FA) is an autosomal recessive disorder that might cause a variety of congenital and developmental abnormalities. The most important features of FA are progressive bone marrow failure and development of malignancies, particularly acute myeloid leukemia and solid tumors. This paper reports the case of a 12-year-old patient with FA assisted at the Stomatology and Bucomaxillofacial Cancer Prevention Service of São Lucas Hospital, Brazil, who had been submitted to bone marrow transplantation (BMT) at the age of 5 and exhibited oral lesions characteristic of chronic graft versus host disease (GVHD). The patient was treated and followed-up for the oral lesions. Eleven years after the BMT, he developed squamous cell carcinoma of the tongue with an aggressive behavior, which was considered an untreatable condition. The patient died few months later from asphyxia at the age of 16. The reasons for development of these malignant conditions are unknown. However, chromosomal instability typically observed in FA cases, BMT factors and GVHD have been considered. Systematic follow-up of these patients allows early and less invasive therapeutic approaches.
authors.affiliation: Clinical Department, Faculty of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Fernanda Gonçalves
authors.initials: FG
authors.lastname: Salum
authors.forename: Gabriela Botelho
authors.initials: GB
authors.lastname: Martins
authors.forename: Maria Antonia Zancanaro
authors.initials: MA
authors.lastname: de Figueiredo
authors.forename: Karen
authors.initials: K
authors.lastname: Cherubini
authors.forename: Liliane Soares
authors.initials: LS
authors.lastname: Yurgel
authors.forename: Cassius
authors.initials: C
authors.lastname: Torres-Pereira
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D002648:Child; D005199:Fanconi Anemia / Q000150:complications* / Q000628:therapy; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D008297:Male; D014062:Tongue Neoplasms / Q000209:etiology*