title: [Local application of concentrated trombocytes and the level of osseointegration of dental titanium implants: a histomorphometrical analysis].
abstract: OBJECTIVE
  In order to achieve better, and, thus an increased bone-implant interface, growth factors have been used over the past few years. All growth factors considered have fundamental role in the growth and development of cells and tissues. Concentrated trombocytes from platelet-rich plasma (CT-PRP) are fraction of the blood. Thrombocytes contain a number of growth factors namely PDGF, TGF-beta, IGF, VEGF and many others, which contribute to the achievement of the increased bone-implant interface, the increased stability of implants and the faster functional loading of implants. The aim of this study was to establish the effect of CT-PRP on bone-implant interface.
  
  
  METHODS
  This experimental study included six dogs in which 24 BCT implants were inserted (4 implants per dog). On the left side of the lower jaw 2 implants were placed with CT-PRP, while on the right side the implants were placed without CT-PRP. The animals were sacrificed after 42, 70, and 98 days. The specimens were examined histomorphometrically, and analyzed 42, 70 and 98 days after the implant insertion. The contacts bone to implant in 16 zones for each analyzed implant were measured according to the established protocol.
  
  
  RESULTS
  Results obtained with histomorphometrical analysis imply the increased bone-to-implant contact by use CT-PRP. The difference of the bone-to-implant contacts between these two groups of inserted implants has been particularly pronounced at six weeks after the implant insertion.
  
  
  CONCLUSIONS
  According to the obtained results in the measurement of the level of osseointegration of the inserted implants, it should be advisable to use the CT-PRP method because it provides the higher level of osseointegration.
authors.affiliation: Vojnomedicinska akademija, Klinika za maksilofacijalnu, oralnu hirurgiju i implantologiju, Odeljenje za implantologiju, Beograd.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Lazić
authors.forename: Marija
authors.initials: M
authors.lastname: Bubalo
authors.forename: Smiljana
authors.initials: S
authors.lastname: Matić
authors.forename: Novak
authors.initials: N
authors.lastname: Stamatović
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D003758:Dental Implantation, Endosseous; D004285:Dogs; D020007:Implants, Experimental; D016348:Osseointegration / Q000502:physiology