title: CEACAM1 in cervical cancer and precursor lesions: association with human papillomavirus infection.
abstract: Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an adhesion molecule expressed in a wide variety of tissues including epithelial cells, leukocytes, and tumors that may establish both homotypic and heterotypic interactions. The aim of this work was to study the protein expression pattern of CEACAM1 in cervical cancer and precursor lesions in the context of human papillomavirus (HPV) infection. We used immunohistochemistry to analyze CEACAM1 expression in formalin-fixed, paraffin-embedded cervical tissues from 15 healthy women, 15 patients with low-grade squamous intraepithelial lesions (SIL), 15 patients with high-grade SIL, and 15 patients with squamous carcinomas. HPV types were identified by PCR. CEACAM1 was either undetectable (13/15) or low (2/15) in normal cervical tissues. By contrast, CEACAM1 expression was increased in high-grade SIL (10 samples staining intermediate/high and 4 samples staining low) as compared with low-grade SIL with undetectable (n=3) or low (n=12) expression. CEACAM1 expression was undetectable or low in cervical carcinoma. Our results suggest that CEACAM1 may be an interesting progression marker in SIL and cervical cancer, in particular due to reported immunoregulatory properties.
authors.affiliation: Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Apartado Postal 2-236, 44281 Guadalajara, Jalisco, Mexico.
authors.forename: Benibelks
authors.initials: B
authors.lastname: Albarran-Somoza
authors.forename: Ramon
authors.initials: R
authors.lastname: Franco-Topete
authors.forename: Vidal
authors.initials: V
authors.lastname: Delgado-Rizo
authors.forename: Felipe
authors.initials: F
authors.lastname: Cerda-Camacho
authors.forename: Lourdes
authors.initials: L
authors.lastname: Acosta-Jimenez
authors.forename: Miguel
authors.initials: M
authors.lastname: Lopez-Botet
authors.forename: Adrian
authors.initials: A
authors.lastname: Daneri-Navarro
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis*; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000096:biosynthesis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000737:chemistry / Q000473:pathology* / Q000821:virology
chemical_list: D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules