title: 4-difluoro-substituted phenl-5-oxohexahydroquinoline derivatives and their effects on calcium channels.
abstract: Twenty new methyl(ethyl) 2,6,6- or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and ten new N,N-diethyl-2,6,6- or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide derivatives have been synthesised and screened for their calcium channel antagonistic activity. The compounds were synthesised by the Hantzsch reaction. Calcium antagonistic activities of the compounds were determined by the tests performed on isolated rat ileum and rat thoracic artery.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. rsimsek@hacettepe.edu.tr
authors.forename: Rahime
authors.initials: R
authors.lastname: Simşek
authors.forename: Miyase Gözde
authors.initials: MG
authors.lastname: Gündüz
authors.forename: Başar
authors.initials: B
authors.lastname: Sirmagül
authors.forename: Cihat
authors.initials: C
authors.lastname: Safak
authors.forename: Kevser
authors.initials: K
authors.lastname: Erol
authors.forename: Anthony
authors.initials: A
authors.lastname: Linden
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D008297:Male; D008958:Models, Molecular; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013895:Thoracic Arteries / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D007202:Indicators and Reagents; D011804:Quinolines