Disparities in HbA1c levels between African-American and non-Hispanic white adults with diabetes: a meta-analysis.
OBJECTIVE
Among individuals with diabetes, a comparison of HbA(1c) (A1C) levels between African Americans and non-Hispanic whites was evaluated. Data sources included PubMed, Web of Science, the Cumulative Index to Nursing and Allied Health, the Cochrane Library, the Combined Health Information Database, and the Education Resources Information Center.


METHODS
We executed a search for articles published between 1993 and 2005. Data on sample size, age, sex, A1C, geographical location, and study design were extracted. Cross-sectional data and baseline data from clinical trials and cohort studies for African Americans and non-Hispanic whites with diabetes were included. Diabetic subjects aged <18 years and those with pre-diabetes or gestational diabetes were excluded. We conducted a meta-analysis to estimate the difference in the mean values of A1C for African Americans and non-Hispanic whites.


RESULTS
A total of 391 studies were reviewed, of which 78 contained A1C data. Eleven had data on A1C for African Americans and non-Hispanic whites and met selection criteria. A meta-analysis revealed the standard effect to be 0.31 (95% CI 0.39-0.25). This standard effect correlates to an A1C difference between groups of approximately 0.65%, indicating a higher A1C across studies for African Americans. Grouping studies by study type (cross-sectional or cohort), method of data collection for A1C (chart review or blood draw), and insurance status (managed care or nonmanaged care) showed similar results.


CONCLUSIONS
The higher A1C observed in this meta-analysis among African Americans compared with non-Hispanic whites may contribute to disparity in diabetes morbidity and mortality in this population.
Kirk
Julienne K
JK
Family and Community Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1084, USA. jkirk@wfubmc.edu
D'Agostino
Ralph B
RB
Bell
Ronny A
RA
Passmore
Leah V
LV
Bonds
Denise E
DE
Karter
Andrew J
AJ
Narayan
K M Venkat
KM
D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D003920:Diabetes Mellitus / Q000097:blood / Q000208:ethnology*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007256:Information Systems / Q000706:statistics & numerical data; D008875:Middle Aged; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data*
D006442:Glycated Hemoglobin