title: Extractive-spectrophotometric determination of disopyramide and irbesartan in their pharmaceutical formulation.
abstract: Picric acid, bromocresol green, bromothymol blue, cobalt thiocyanate and molybdenum(V) thiocyanate have been tested as spectrophotometric reagents for the determination of disopyramide and irbesartan. Reaction conditions have been optimized to obtain coloured comoplexes of higher sensitivity and longer stability. The absorbance of ion-pair complexes formed were found to increases linearity with increases in concentrations of disopyramide and irbesartan which were corroborated by correction coefficient values. The developed methods have been successfully applied for the determination of disopyramide and irbesartan in bulk drugs and pharmaceutical formulations. The common excipients and additives did not interfere in their determination. The results obtained by the proposed methods have been statistically compared by means of student t-test and by the variance ratio F-test. The validity was assessed by applying the standard addition technique. The results were compared statistically with the official or reference methods showing a good agreement with high precision and accuracy.
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Omar Al-Mukhtar University, Faculty of Pharmacy, Derna, Libya. ezzat_hisham@yahoo.com
authors.forename: Hisham E
authors.initials: HE
authors.lastname: Abdellatef
mesh_terms: D001713:Biphenyl Compounds / Q000032:analysis* / Q000737:chemistry; D001961:Bromcresol Green / Q000737:chemistry; D001979:Bromthymol Blue / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003035:Cobalt / Q000737:chemistry; D016001:Confidence Intervals; D004206:Disopyramide / Q000032:analysis* / Q000737:chemistry; D000077405:Irbesartan; D010851:Picrates / Q000737:chemistry; D012015:Reference Standards; D013777:Tetrazoles / Q000032:analysis* / Q000737:chemistry; D013861:Thiocyanates / Q000737:chemistry
chemical_list: D001713:Biphenyl Compounds; D010851:Picrates; D013777:Tetrazoles; D013861:Thiocyanates; C038956:cobalt thiocyanate; D003035:Cobalt; D001961:Bromcresol Green; C005858:picric acid; D004206:Disopyramide; D000077405:Irbesartan; D001979:Bromthymol Blue