Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3.
A new class of pyrimidine-based Janus tyrosine kinase 3 (JAK3) inhibitors are described. Many of these inhibitors showed low nanomolar activity against JAK3.
Chen
Jack J
JJ
Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Rd., Mason, OH 45040, USA. jack.01.chen@gmail.com
Thakur
Kumar D
KD
Clark
Michael P
MP
Laughlin
Steven K
SK
George
Kelly M
KM
Bookland
Roger G
RG
Davis
Jan R
JR
Cabrera
Edward J
EJ
Easwaran
Vijay
V
De
Biswanath
B
George Zhang
Y
Y
D053616:Janus Kinase 3 / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*
D011743:Pyrimidines; D053616:Janus Kinase 3