title: Transient loss of the Y-chromosome in an elderly man with anemia and lead poisoning: chance occurrence or a clonal marker of the underlying hematological abnormality?
abstract: One of the most important environmental and occupational pollutants is lead. Cytogenetic damage is known to occur to many individuals exposed to lead, e.g., outdoor and car painters, traffic policemen, gasoline station attendants, etc.1 Chronic lead exposure affects many organ systems leading to a gradual decline in the so-called safe blood lead levels over time.
authors.affiliation: Department of Hematology, Clinic University Hospital of Heraklion P.O. Box 2208, 710 03 Heraklion, Crete, Greece.
authors.forename: Elpis
authors.initials: E
authors.lastname: Mantadakis
authors.forename: Anna M
authors.initials: AM
authors.lastname: Boula
authors.forename: George
authors.initials: G
authors.lastname: Girakis
authors.forename: Irini M
authors.initials: IM
authors.lastname: Xilouri
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Foudoulakis
authors.forename: George
authors.initials: G
authors.lastname: Samonis
mesh_terms: D000368:Aged; D000740:Anemia / Q000235:genetics* / Q000503:physiopathology; D041322:Chromosomes, Human, Y; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000009:adverse effects; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D007854:Lead / Q000097:blood / Q000633:toxicity*; D007855:Lead Poisoning / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D004785:Environmental Pollutants; D007854:Lead