title: Enzymatic gluten detoxification: the proof of the pudding is in the eating!
abstract: Celiac disease is caused by an immune response to the dietary protein gluten. The only available treatment is the strict exclusion of gluten from the diet; however, this is marred by the virtual omnipresence of this protein. The enzymatic degradation of gluten might become an alternative to the gluten-free diet, and recent work indicates that such approaches are getting close to being tested in clinical trials.
authors.affiliation: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Stepniak
authors.forename: Frits
authors.initials: F
authors.lastname: Koning
mesh_terms: D001711:Biotransformation / Q000502:physiology; D002446:Celiac Disease / Q000178:diet therapy* / Q000503:physiopathology; D003546:Cysteine Endopeptidases / Q000008:administration & dosage / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D019587:Dietary Supplements; D005983:Glutens / Q000378:metabolism*; D006801:Humans; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000008:administration & dosage / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D005983:Glutens; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases; D003546:Cysteine Endopeptidases