Obstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue.
Oxidized low density lipoprotein (ox-LDL) molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients.
Comert
Mustafa
M
Ustundag
Yucel
Y
Tekin
Ishak Ozel
IO
Gun
Banu Dogan
BD
Barut
Figen
F
D001706:Biopsy; D005786:Gene Expression Regulation; D006801:Humans; D041781:Jaundice, Obstructive / Q000473:pathology*; D008077:Lipoproteins, LDL / Q000096:biosynthesis* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D018384:Oxidative Stress
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein