title: [Pathogen persistence in infectious pathology].
abstract: Problems of microorganism's persistence in infectious pathology are discussed in this work. Persistence of bacteria as the form of procaryotic and eucaryotic cells symbiosis unlimitedly long coexistence is considered. Questions of the microbial evolution formed in constant collision of the infective agent with macroorganism defense mechanisms are discussed. The spectrum of known mechanisms bacterial survival in conditions of an infected organism is considered. For discussion the problem of microbial persistence it is offered to include as model alongside with an independent cell, a microbial population as complex self-organizing system--the original "superorganism" having universal chemical regulation, the determining density of a population and equation of some physiological functions. It is offered to consider the host colonization resistance as a phenomenon of general biology directed on maintenance of a microecological homeostasis as a result of symbiotic interactions of an organism and it autochthonous microflora with the "key" kinds of biotope protection. The use of persistence characteristics of microorganisms is proved as a target in conditions of intermicrobial interaction of its allochthonous and autochthonous microflorae. Practical value of such approach in infectious pathology is shown.
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
mesh_terms: D000818:Animals; D001419:Bacteria / Q000254:growth & development* / Q000472:pathogenicity; D018407:Bacterial Physiological Phenomena; D005075:Biological Evolution; D003141:Communicable Diseases / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D013559:Symbiosis; D014774:Virulence