title: Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae.
abstract: Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite. Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification.
authors.affiliation: Departamento de Microbiología II. Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
authors.forename: Jael
authors.initials: J
authors.lastname: Sotelo
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Rodríguez-Gabriel
mesh_terms: D018053:Arsenites / Q000494:pharmacology*; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D010766:Phosphorylation / Q000187:drug effects; D021381:Protein Transport / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D018053:Arsenites; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases; C015001:arsenite