title: Acute myopia and angle closure caused by topiramate, a drug used for prophylaxis of migraine.
abstract: Acute transient myopia with shallowing of the anterior chamber is a rare idiosyncratic response to many systemic and topical medications, including sulfonamides. Several such cases have been reported in the past, but are less frequently reported in recent times. We report a case of acute progressive myopia and bilateral angle closure due to Topiramate--a drug used for epilepsy and migraine prophylaxis.
authors.affiliation: Department of Ophthalmology, MGM Hospital, Kamothe, Navi Mumbai, Maharashtra, India.
authors.forename: Charuta Mandke
authors.initials: CM
authors.lastname: Desai
authors.forename: Suresh J
authors.initials: SJ
authors.lastname: Ramchandani
authors.forename: Sunil G
authors.initials: SG
authors.lastname: Bhopale
authors.forename: Sushama S
authors.initials: SS
authors.lastname: Ramchandani
mesh_terms: D000328:Adult; D000867:Anterior Chamber / Q000000981:diagnostic imaging / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008881:Migraine Disorders / Q000517:prevention & control*; D009216:Myopia / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D012029:Refraction, Ocular / Q000187:drug effects; D000077236:Topiramate; D014463:Ultrasonography
chemical_list: D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose