title: Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.
abstract: In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.
authors.affiliation: Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143-0648, USA. leungj@anesthesia.ucsf.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Leung
authors.forename: L P
authors.initials: LP
authors.lastname: Sands
authors.forename: M
authors.initials: M
authors.lastname: Rico
authors.forename: K L
authors.initials: KL
authors.lastname: Petersen
authors.forename: M C
authors.initials: MC
authors.lastname: Rowbotham
authors.forename: J B
authors.initials: JB
authors.lastname: Dahl
authors.forename: C
authors.initials: C
authors.lastname: Ames
authors.forename: D
authors.initials: D
authors.lastname: Chou
authors.forename: P
authors.initials: P
authors.lastname: Weinstein
mesh_terms: D000588:Amines / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D003693:Delirium / Q000209:etiology* / Q000517:prevention & control*; D005240:Feasibility Studies; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D010147:Pain Measurement / Q000187:drug effects; D010149:Postoperative Pain / Q000209:etiology* / Q000517:prevention & control*; D010865:Pilot Projects; D015990:Placebo Effect; D011292:Premedication / Q000379:methods*; D013131:Spine / Q000601:surgery; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin