Prognostic factors and expression of p53 and mdm-2 in uterine sarcomas.
OBJECTIVE
To evaluate the clinicopathologic prognostic factors of uterine sarcoma, and determine whether overexpression of p53 and mdm-2 proteins correlate with overall survival and prognostic factors.


METHODS
Thirty specimens from 43 patients with uterine sarcoma were available for slide review and evaluated by immunohistochemistry at Yonsei and Ajou University Medical Centers for the expression of p53 and mdm-2.


RESULTS
Overall survival was found to correlate to histologic type of uterine sarcoma, surgical stage, tumor grade, and mitotic index. Whereas 63% of the sarcomas expressed p53, with a significant correlation to overall survival, 60% expressed mdm-2, with a significant correlation to the mitotic index but not to overall survival.


CONCLUSIONS
Histologic type, surgical stage, tumor grade, mitotic index, and p53 expression were prognostic factors of the overall survival of patients with uterine sarcoma.
Kim
S H
SH
Department of Obstetrics and Gynecology, Women's Cancer Clinic, Institute of Women's Life Science, Yonsei University College of Medicine, Seoul, South Korea.
Kim
J W
JW
Kim
Y T
YT
Kim
J H
JH
Yoon
B S
BS
Ryu
H S
HS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D007723:Korea; D008875:Middle Aged; D009367:Neoplasm Staging / Q000009:adverse effects*; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D012189:Retrospective Studies; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology
D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2