title: Sustained viral response of a case of acute hepatitis C virus infection via needle-stick injury.
abstract: A 29-year-old nurse with a hepatitis C virus (HCV) infection caused by needle-stick injury was treated with interferon-beta starting about one year after the onset of acute hepatitis. The patient developed acute hepatitis C with symptoms of general fatigues, jaundice, and ascites 4 wk after the needle-stick injury. When these symptoms were presented, the patient was pregnant by artificial insemination. She hoped to continue her pregnancy. After delivery, biochemical liver enzyme returned to normal levels. Nevertheless, HCV RNA was positive and the pathological finding indicated a progression to chronicity. The genotype was 1b with low viral load. Daily intravenous injection of interferon-beta at the dosage of six million units was started and continued for eight weeks. HCV was eradicated without severe adverse effects. In acute hepatitis C, delaying therapy is considered to reduce the efficacy but interferon-beta therapy is one of the useful treatments for hepatitis C infection in chronic phase.
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai 980-8574, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kogure
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Noriatsu
authors.initials: N
authors.lastname: Kanno
authors.forename: Koji
authors.initials: K
authors.lastname: Fukushima
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yamagiwa
authors.forename: Futoshi
authors.initials: F
authors.lastname: Nagasaki
authors.forename: Eiji
authors.initials: E
authors.lastname: Kakazu
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Osamu
authors.initials: O
authors.lastname: Kido
authors.forename: Yu
authors.initials: Y
authors.lastname: Nakagome
authors.forename: Masashi
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D000208:Acute Disease; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000472:pathogenicity*; D006526:Hepatitis C / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology / Q000635:transmission; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional; D016899:Interferon-beta / Q000627:therapeutic use; D016602:Needlestick Injuries / Q000150:complications*; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D016899:Interferon-beta