Coronary microembolization.
Atherosclerotic plaque rupture is the key event in the pathogenesis of acute coronary syndromes and it also occurs during coronary interventions. Atherosclerotic plaque rupture does not always result in complete thrombotic occlusion of the epicardial coronary artery with subsequent impending myocardial infarction, but may in milder forms result in the embolization of atherosclerotic and thrombotic debris into the coronary microcirculation. This review summarizes the present experimental pathophysiology of coronary microembolization in animal models of acute coronary syndromes and highlights the main consequences of coronary microembolization--reduced coronary reserve, microinfarction, inflammation and oxidative modification of contractile proteins, contractile dysfunction and perfusion-contraction mismatch.Furthermore, the review presents the available clinical evidence for coronary microembolization in patients and compares the clinical observations with observations in the experimental model.
Skyschally
Andreas
A
Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Germany, gerd.heusch@uni-essen.de.
Leineweber
Kkirsten
K
Gres
Petra
P
Haude
Michael
M
Erbel
Raimund
R
Heusch
Gerd
G
D000818:Animals; D003326:Coronary Circulation; D003328:Coronary Thrombosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004617:Embolism / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D014335:Tropomyosin / Q000378:metabolism
D014335:Tropomyosin