Potent benzimidazolone based human beta(3)-adrenergic receptor agonists.
The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed.
Finley
Don R
DR
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
Bell
Michael G
MG
Borel
Anthony G
AG
Bloomquist
William E
WE
Cohen
Marlene L
ML
Heiman
Mark L
ML
Kriauciunas
Aidas
A
Matthews
Donald P
DP
Miles
Tania
T
Neel
David A
DA
Rito
Christopher J
CJ
Sall
Daniel J
DJ
Shuker
Anthony J
AJ
Stephens
Thomas W
TW
Tinsley
Frank C
FC
Winter
Mark A
MA
Jesudason
Cynthia D
CD
D058673:Adrenergic beta-3 Receptor Antagonists; D000318:Adrenergic beta-Agonists / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans
D058673:Adrenergic beta-3 Receptor Antagonists; D000318:Adrenergic beta-Agonists; D001562:Benzimidazoles; C014353:benzimidazolone