CEACAMs: their role in physiology and pathophysiology.
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAMs have also been identified as receptors for host-specific viruses and bacteria in mice and humans, respectively, making these proteins an interesting example of pathogen-host co-evolution. Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo.
Kuespert
Katharina
K
Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universität Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
Pils
Stefan
S
Hauck
Christof R
CR
D000818:Animals; D030801:Animals, Genetically Modified; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D001419:Bacteria / Q000472:pathogenicity; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D019143:Evolution, Molecular; D006801:Humans; D007328:Insulin / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D018919:Neovascularization, Physiologic; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*; D014780:Viruses / Q000472:pathogenicity
D015703:Antigens, CD; C069847:CD66 antigens; C075729:CEACAM3 protein, human; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D007328:Insulin; D020033:Protein Isoforms