Occurrence of sleep disorders in the families of narcoleptic patients.
First-degree relatives of narcoleptic subjects (probands) may have sleep pathology related to the transmission of the disorder through their family members. The authors examined four groups: probands (n = 96), first-degree relative (n = 337), environmental reference (n = 85), and general population (n = 6,694) groups. Compared with the general population, family members have a 75-fold increased risk for narcolepsy. They are also at greater risk for insufficient sleep syndrome (odds ratio [OR] 6.1), nocturnal eating (OR 5.7), and adjustment sleep disorder (OR 3.1).
Ohayon
Maurice M
MM
Stanford Sleep Epidemiology, School of Medicine, Stanford University, Palo Alto, CA 94303, USA. mohayon@stanford.edu
Okun
Michele L
ML
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005190:Family; D005260:Female; D006801:Humans; D015994:Incidence; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000453:epidemiology; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology