Reg-Ialpha in the diagnosis of acute coronary syndrome--a pilot study.
The commonly used laboratory markers of coronary involvement in subjects with acute coronary syndrome (ACS) are not yet myocardial ischemia-specific and show a late irreversible involvement of the myocardium. A laboratory test has been searched for in order to distinguish persons with myocardial ischemia and typical CAD symptoms to CAD-free individuals. Reg-Ialpha is the product of Reg-I gene which plays a significant role in myocardial regeneration. 38 individuals with suspicion of acute coronary syndrome were tested on admission, after 2 and 6 hours. In all of them cardiac troponin I, myoglobin, C-reactive protein (CRP) and Reg-I alpha were analysed. Our findings did not support the hypothesis that measurement of Reg-Ia maybe the useful marker of myocardial stress.
Stejskal
David
D
Department of Laboratory Medicine and Internal Department Sternberk Hospital, Czech Republic. david.stejskal@quick.cz
Lacnak
Borek
B
Karpisek
Michal
M
D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D051847:Lithostathine / Q000097:blood*; D009203:Myocardial Infarction / Q000175:diagnosis*; D009211:Myoglobin / Q000097:blood; D019210:Troponin I / Q000097:blood
D015415:Biomarkers; D051847:Lithostathine; D009211:Myoglobin; C497617:REG1A protein, human; D019210:Troponin I; D002097:C-Reactive Protein