AmBisome treatment of fungal sinusitis in severe immunocompromised patient with acute lymphoblastic leukemia relapsed after autologous peripheral blood transplantation.
This report describes the case of fungal sinusitis in severely immunocompromised 32-year-old male with common-type acute lymphoblastic leukemia who relapsed after autologous peripheral blood transplantation. Empirical therapy with antibiotics and conventional amphotericin B failed to resolve the infection. Following therapy with AmBisome his symptoms abated and significantly improved scan picture was seen.
Rokicka
Malgorzata
M
Department of Hematology and Oncology, Medical University of Warsaw, Poland. mrokicka@amwaw.edu.pl
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy; D013293:Enterococcus faecalis / Q000302:isolation & purification; D017809:Fatal Outcome; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage / Q000009:adverse effects; D016867:Immunocompromised Host; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008081:Liposomes; D008297:Male; D009181:Mycoses / Q000150:complications / Q000188:drug therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy; D011183:Postoperative Complications / Q000188:drug therapy*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D016958:Pseudomonas putida / Q000302:isolation & purification; D011654:Pulmonary Edema / Q000209:etiology; D011743:Pyrimidines / Q000627:therapeutic use; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D014182:Transplantation, Autologous; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D016756:Immunoglobulins, Intravenous; D008081:Liposomes; D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; D003561:Cytarabine; D000666:Amphotericin B; D065819:Voriconazole; D015255:Idarubicin