Unraveling the transcriptional network controlling ES cell pluripotency.
Embryonic stem cells (ES cells) are powerful tools for genetic engineering and hold significant potential for regenerative medicine. Recent work provides new insights into ES cell pluripotency and delineates separate transcriptional pathways in ES cells for maintenance of the undifferentiated state and for self-renewal.
Rao
Sridhar
S
Division of Hematology-Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Orkin
Stuart H
SH
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000502:physiology; D051379:Mice; D050814:Octamer Transcription Factor-3 / Q000502:physiology; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D034622:RNA Interference; D050791:STAT Transcription Factors / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
D053605:Leukemia Inhibitory Factor; D050814:Octamer Transcription Factor-3; D050791:STAT Transcription Factors