title: Vanadium complex of 2-(2'-Pyridyl)-4,5-dicyanoimidazole showing spermicidal and cytotoxic properties.
abstract: Two complexes having the formulas VO(DCIPy)2(H2O).1.5H2O and VO(DCIPy)2(H2O).2MeOH have been synthesized and characterized (DCIPy = 2-(2'-pyridyl)-4,5-dicyanoimidazolato). The methanol solvated species has been studied by X-ray diffraction, and single crystals form in the space group P2(1)/n. The hydrated species was studied by electron paramagnetic resonance spectroscopy in both the solid state and in a frozen solution, and the values of A( parallel) examined using the additivity relationship. The hydrated species was shown to exhibit both spermicidal and cytoxic properties.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA. gless@umich.edu
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Less
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Ockwig
authors.forename: Paul G
authors.initials: PG
authors.lastname: Rasmussen
authors.forename: Gary D
authors.initials: GD
authors.lastname: Smith
authors.forename: Laura M
authors.initials: LM
authors.lastname: Keller
authors.forename: John C
authors.initials: JC
authors.lastname: Drach
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D008297:Male; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects; D013089:Spermatocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects; D013329:Structure-Activity Relationship; D013997:Time Factors; D014639:Vanadium / Q000737:chemistry*
chemical_list: C519860:2-(2'-pyridyl)-4,5-dicyanoimidazole; D000998:Antiviral Agents; D007093:Imidazoles; D009942:Organometallic Compounds; D013089:Spermatocidal Agents; D014639:Vanadium