title: Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus.
abstract: Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Katherine N
authors.initials: KN
authors.lastname: Maloney
authors.forename: Wenshan
authors.initials: W
authors.lastname: Hao
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Jay
authors.initials: J
authors.lastname: Gibbons
authors.forename: John
authors.initials: J
authors.lastname: Hucul
authors.forename: Deborah
authors.initials: D
authors.lastname: Roll
authors.forename: Sean F
authors.initials: SF
authors.lastname: Brady
authors.forename: Frank C
authors.initials: FC
authors.lastname: Schroeder
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005658:Fungi / Q000378:metabolism*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D006574:Heterocyclic Compounds, 2-Ring; D050796:STAT3 Transcription Factor; C520910:phaeosphaeride A