Effects of poly-2-methoxyethylacrylate (PMEA)-coating on CPB circuits.
OBJECTIVE
In this study, the immuno- and neuroprotective effect of a novel cardiopulmonary bypass coating was investigated.


METHODS
Thirty nine patients scheduled for elective coronary artery bypass grafting were randomly assigned to either PMEA-coated (n = 19) or non-coated CPB circuits (n = 20). Pericardial suction blood was separated and retransfused only if needed at the end of operation. Neurocognitive functions were examined preoperatively and 7-10 days postoperatively using a standard neuropsychological test battery. Assuming an inflammatory etiology, the most cogent inflammatory markers were perioperatively analyzed.


RESULTS
Postoperatively, patients of the PMEA-coated group performed better in Go/NoGo and Mini-Mental-test than patients of the non-coated group (p < 0.04). Other neurocognitive testing did not reveal significant differences between the groups. Although most inflammatory parameters showed a significant intraindividual increase during or shortly after CPB, there was no difference in inflammatory alteration between the groups.


CONCLUSIONS
PMEA-coating of cardiopulmonary bypass surfaces revealed some minor benefits in preservation of neurocognitive functions after surgery. The immediate inflammatory response remained mostly unaffected. Suction blood separation may additionally contribute to proper postoperative outcome.
Skrabal
Christian A
CA
Department of Cardiac Surgery, University of Rostock, Schillingallee 35, 18057, Rostock, Germany.
Khosravi
Amir
A
Westphal
Bernd
B
Steinhoff
Gustav
G
Liebold
Andreas
A
D000179:Acrylates; D000917:Antibody Formation; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D003071:Cognition; D003072:Cognition Disorders / Q000517:prevention & control*; D001026:Coronary Artery Bypass / Q000379:methods*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011108:Polymers
D000179:Acrylates; D015415:Biomarkers; D011108:Polymers; C413485:poly(2-methoxyethylacrylate)