title: Insight in frontotemporal dementia: conceptual analysis and empirical evaluation of the consensus criterion "loss of insight" in frontotemporal dementia.
abstract: The objective of this study was to suggest a new formulation of the core research diagnostic consensus criterion "loss of insight" in frontotemporal dementia (FTD). Eight patients with FTD (diagnoses made by interviews, medical and neuropsychological examination, CT scan, and regional cerebral glucose metabolism measured by positron emission tomography (PET) participated in the study). The results indicated that insight was present in three out of eight patients, and that insight appears to be a heterogeneous concept. Two types of insight emerged: Emotional insight associated with frontotemporal functions, and cognitive insight, related to posterior cognitive functions. These results suggest that loss of insight should not serve as a core criterion on FTD, but serves well as a supportive criterion of the disease.
authors.affiliation: Department of Public Health and Caring Sciences, Centre for Bioethics at Karolinska Institutet and Uppsala University, Uppsala, Sweden. kathinka.evers@bioethics.uu.se
authors.forename: Kathinka
authors.initials: K
authors.lastname: Evers
authors.forename: Lena
authors.initials: L
authors.lastname: Kilander
authors.forename: Maria
authors.initials: M
authors.lastname: Lindau
mesh_terms: D000339:Affect; D000368:Aged; D000704:Analysis of Variance; D001364:Awareness; D003210:Concept Formation; D003704:Dementia / Q000145:classification / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D012649:Self Concept; D018709:Statistics, Nonparametric