Dynamics of spatial resolution of single units in the lateral geniculate nucleus of cat during brief visual stimulation.
Sharpness of vision depends on the resolution of details conveyed by individual neurons in the visual pathway. In the dorsal lateral geniculate nucleus (LGN), the neurons have receptive fields with center-surround organization, and spatial resolution may be measured as the inverse of center size. We studied dynamics of receptive field center size of single LGN neurons during the response to briefly (400-500 ms) presented static light or dark spots. Center size was estimated from a series of spatial summation curves made for successive 5-ms intervals during the stimulation period. The center was wide at the start of the response, but shrank rapidly over 50-100 ms after stimulus onset, whereupon it widened slightly. Thereby, the spatial resolution changed from coarse-to-fine with average peak resolution occurring approximately 70 ms after stimulus onset. The changes in spatial resolution did not follow changes of firing rate; peak firing appeared earlier than the maximal spatial resolution. We suggest that the response initially conveys a strong but spatially coarse message that might have a detection and tune-in function, followed by transient transmission of spatially precise information about the stimulus. Experiments with spots presented inside the maximum but outside the minimum center width suggested a dynamic reduction in number of responding neurons during the stimulation; from many responding neurons initially when the field centers are large to fewer responding neurons as the centers shrink. Thereby, there is a change from coarse-to-fine also in the recruitment of responding neurons during brief static stimulation.
Ruksenas
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O
Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, PO Box 1103 Blindern, N-0717 Oslo, Norway.
Bulatov
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A
Heggelund
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P
D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D000818:Animals; D001931:Brain Mapping; D002415:Cats; D005829:Geniculate Bodies / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation; D013028:Space Perception / Q000502:physiology*; D014795:Visual Pathways / Q000166:cytology / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*