A case of voltage-gated potassium channel antibody-related limbic encephalitis.
BACKGROUND
A 56-year-old man presented to hospital with a 6-month history of recurrent episodes of altered behavior and 'odd' episodes. He had become apathetic and uninterested in his family. He had no relevant past medical or family history. General and physical neurological examinations were unremarkable, as was bedside cognitive testing.


METHODS
Brain MRI scan, 24-h electroencephalogram, serum and cerebrospinal fluid testing for voltage-gated potassium channel antibodies, blood screening for tumors, CT scans of the chest, abdomen and pelvis, whole-body PET scan, neuropsychological examination, brain 18F-fluorodeoxyglucose-PET scan.


METHODS
Voltage-gated potassium channel antibody-related limbic encephalitis.


RESULTS
Antiepileptic drugs, immunomodulatory therapy, oral steroids, plasma exchange.
Harrower
Tim
T
Addenbrooke's Hospital, Cambridge, UK. timothy.harrower@addenbrookes.nhs.uk
Foltynie
Tom
T
Kartsounis
Luke
L
De Silva
Rajith N
RN
Hodges
John R
JR
D000927:Anticonvulsants / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology*; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D020363:Limbic Encephalitis / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D012964:Sodium / Q000097:blood; D013256:Steroids / Q000627:therapeutic use
D000927:Anticonvulsants; D001323:Autoantibodies; D007155:Immunologic Factors; D024642:Potassium Channels, Voltage-Gated; D013256:Steroids; D012964:Sodium