title: N-carboxamido-staurosporine and selina-4(14),7(11)-diene-8,9-diol, new metabolites from a marine Streptomyces sp.
abstract: In our screening of micro-organisms for novel bioactive natural products, a new staurosporinone, N-carboxamido-staurosporine (1c), and a new sesquiterpene, (5S,8S,9R, 10S)-selina-4(14),7(11)-diene-8,9-diol (2a), were isolated from the culture broth of the marine-derived Streptomyces sp. QD518. Their structures were determined by spectroscopic methods and by comparison of the NMR data with those of structurally related known natural products, which were isolated from the same strain.
authors.affiliation: Department of Organic and Biomolecular Chemistry, University of Göttingen, Germany.
authors.forename: Shao Jie
authors.initials: SJ
authors.lastname: Wu
authors.forename: Serge
authors.initials: S
authors.lastname: Fotso
authors.forename: Fuchao
authors.initials: F
authors.lastname: Li
authors.forename: Song
authors.initials: S
authors.lastname: Qin
authors.forename: Gerhard
authors.initials: G
authors.lastname: Kelter
authors.forename: Heinz H
authors.initials: HH
authors.lastname: Fiebig
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification; D000935:Antifungal Agents / Q000302:isolation & purification; D045744:Cell Line, Tumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C513058:N-carboxamido-staurosporine; D012717:Sesquiterpenes; C513060:selina-4(14),7(11)-diene-8,9-diol; D019311:Staurosporine