title: Manaarenolides A-I, diterpenoids from the soft coral Sinularia manaarensis.
abstract: Nine cembrane-type diterpenoids, manaarenolides A-I (1-9), along with two known cembranolides, 10 and 11, have been isolated from the ethyl acetate extract of the Taiwanese soft coral Sinularia manaarensis. Among these metabolites, diterpenes (1, 2, 5, and 6) were discovered for the first time as the hydroperoxycembranolides possessing a delta-lactone ring. The 13-epimeric metabolites 7 and 8 have been shown to exhibit moderate cytotoxic activity against Hepa59T/VGH, KB, Hela, and Med cancer cell lines. The biosynthetic relationship between these new metabolites and 10 and 11 is also discussed.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Chih-Hua
authors.initials: CH
authors.lastname: Chao
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D013624:Taiwan
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes