title: Design of highly efficient receptor sites by combination of cyclodextrin units and molecular cavity in TiO2 ultrathin layer.
abstract: A highly effective approach was developed for sensitive detection of organic substances in water. In order to achieve high sensitivity and selective detection for aromatic compounds, cyclodextrin (CD) hosts and imprinting effects were combined to fabricate binding sites within TiO(2) ultrathin layer. The electrode surface was modified with ultrathin TiO(2) gel film containing a 2:1 complex of beta-CD and bisphenol A (BPA), and then the BPA moiety was removed by washing. The resulting BPA-imprinted TiO(2)/beta-CD film showed specific and sensitive detection of BPA, as confirmed by quartz crystal microbalance (QCM) and cyclic surface-polarization impedance (cSPI) measurements. The high selectivity for BPA relative to structurally related guest molecules was estimated to be 1.6-3.4 at the guest concentration of 2x10(-7)M, and was considered to arise from the synergic effect of the binding site.
authors.affiliation: Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Kitakyushu 808-0135, Japan.
authors.forename: Do-Hyeon
authors.initials: DH
authors.lastname: Yang
authors.forename: Myung-Jong
authors.initials: MJ
authors.lastname: Ju
authors.forename: Aya
authors.initials: A
authors.lastname: Maeda
authors.forename: Kenshi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Toko
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Toyoki
authors.initials: T
authors.lastname: Kunitake
mesh_terms: D001559:Benzhydryl Compounds; D001665:Binding Sites; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D010636:Phenols / Q000032:analysis*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D020099:Coated Materials, Biocompatible; D003505:Cyclodextrins; D010636:Phenols; D014025:Titanium; D014874:Water Pollutants, Chemical; C009495:titanium dioxide; C006780:bisphenol A; D000098826:Bisphenol A Compounds