ScoC and SinR negatively regulate epr by corepression in Bacillus subtilis.
Negative regulation of epr in Bacillus subtilis 168 is mediated jointly by both ScoC and SinR, which bind to their respective target sites 62 bp apart. Increasing the distance between the two sites abolishes repression, indicating that the two proteins interact, thereby suggesting a mechanism of corepression.
Kodgire
Prashant
P
School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Dixit
Madhulika
M
Rao
K Krishnamurthy
KK
D001412:Bacillus subtilis / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D015536:Down-Regulation; D015964:Gene Expression Regulation, Bacterial; D010447:Peptide Hydrolases / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
D001426:Bacterial Proteins; D012097:Repressor Proteins; C442131:ScoC protein, Bacillus subtilis; D014157:Transcription Factors; C076733:FlaD protein, Bacteria; D010447:Peptide Hydrolases