Regiospecific synthesis of 4-alkoxy and 4-amino substituted 2-trifluoromethyl pyrroles.
A simple and regiospecific synthesis of 4-alkoxy(amino)-2-trifluoromethyl pyrroles from 5-azido-4-alkoxy(amino)-1,1,1-trifluoro-pent-3-en-2-ones by an aza-Wittig cyclization of aminophosphoranes is described. The structures of the pyrroles and their synthetic intermediates were supported by NMR and HRMS analysis.
Zanatta
Nilo
N
Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, CEP-97105-900, Santa Maria, RS, Brazil. zanatta@base.ufsm.br
Schneider
Juliana M F M
JM
Schneider
Paulo H
PH
Wouters
Ana D
AD
Bonacorso
Helio G
HG
Martins
Marcos A P
MA
Wessjohann
Ludger A
LA
D002625:Chemistry, Organic / Q000379:methods*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D006845:Hydrocarbons, Fluorinated; D011758:Pyrroles