Bisphosphonate-associated osteonecrosis of the jaw: conclusions based on an analysis of case series.
ONJ appears to be associated with BPs; however, the pathophysiology, incidence, and co-morbidities require further investigation. The major risk factors identified to date appear to be cancer (or chemotherapy for cancer) and dental procedures or oral trauma. A clear definition of ONJ is critical to understanding this disease entity. Although recommendations regarding the prevention and management of ONJ exist, clinical studies are needed to establish more definitive guidelines for the management of ONJ. The use of intensive hyperbaric oxygen therapy may be beneficial to patients with ONJ.
Landesberg
Regina
R
Division of Oral and Maxillofacial Surgery, Columbia University College of Dental Medicine, USA. RL1351@columbia.edu
Wilson
Thomas
T
Grbic
John T
JT
D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D006934:Hypercalcemia / Q000188:drug therapy; D007571:Jaw Diseases / Q000139:chemically induced* / Q000628:therapy; D009101:Multiple Myeloma / Q000188:drug therapy; D010020:Osteonecrosis / Q000139:chemically induced* / Q000628:therapy; D010024:Osteoporosis / Q000188:drug therapy; D014081:Tooth Extraction / Q000009:adverse effects
D050071:Bone Density Conservation Agents; D004164:Diphosphonates