Changes in the prooxidant and antioxidant status of tissues during paraneoplastic processes.
Electron paramagnetic resonance was used to identify paramagnetic centers in the blood and liver of laboratory rats with S-45 sarcoma and mice with Ehrlich carcinoma. Paraneoplastic changes in prooxidant and antioxidant activity of the blood and liver tissue, mitochondrial respiration, and NO metabolism and inhibition of antioxidant processes contribute to impairment of cell membrane structures, erythrocyte hemolysis, and hypoxia. An important role of these processes in the pathogenesis of paraneoplastic anemia is confirmed by the positive effect of antioxidant and membrane-stabilizing therapy.
Kipiani
V A
VA
Department of Pathophysiology, Tbilisi State Medical University. kipiani@tsmu.edu
Gambashidze
K G
KG
Bezhitashvili
N D
ND
Kipiani
N V
NV
Pavliashvili
N S
NS
D000740:Anemia / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D002286:Carcinoma, Ehrlich Tumor; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects / Q000648:ultrastructure; D004578:Electron Spin Resonance Spectroscopy; D008099:Liver / Q000737:chemistry*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009479:Neuropeptides / Q000008:administration & dosage; D010084:Oxidation-Reduction; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017382:Reactive Oxygen Species / Q000032:analysis* / Q000097:blood; D012509:Sarcoma
D000975:Antioxidants; D009479:Neuropeptides; D017382:Reactive Oxygen Species; C091912:plaferon