title: Study of a pingyangmycin delivery system: Zein/Zein-SAIB in situ gels.
abstract: Venous malformations (VM) are common vascular abnormality, and their management remains difficult. Pingyangmycin hydrochloride (PYM) is a useful sclerosant to treat venous malformations. This study was aimed to evaluate the effect of a new drug delivery system, PYM-loaded Zein/Zein-sucrose acetate isobutyrate (SAIB) in situ gels, in gelling and extending the local release of PYM. It was demonstrated that in vitro and in vivo release of PYM from the in situ gels could be extended up to 7 and 4 days, respectively. SAIB could significantly cut down the initial burst of PYM from the in situ gels (P<0.05). The possible gel forming and drug release mechanisms were described according to the morphology analysis by atomic force microscopy (AFM), optical microscopy and SEM. The gel forming efficacy and the viscosity of in situ gel solutions were satisfying.
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
authors.forename: Zibin
authors.initials: Z
authors.lastname: Gao
authors.forename: Pingtian
authors.initials: P
authors.lastname: Ding
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Shi
authors.forename: Shuqin
authors.initials: S
authors.lastname: Yuan
authors.forename: Jing
authors.initials: J
authors.lastname: Wei
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005079:Excipients; D005782:Gels; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011817:Rabbits; D013395:Sucrose / Q000031:analogs & derivatives* / Q000737:chemistry; D014783:Viscosity; D015028:Zein / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D005079:Excipients; D005782:Gels; D001761:Bleomycin; D013395:Sucrose; C025703:bleomycetin; D015028:Zein; C002885:sucrose acetate isobutyrate