Aging: progeria and the lamin connection.
The relationship between progerias--diseases that resemble premature aging--and the normal aging process has been a source of debate in the aging research community. A recent study finds that LMNA, a gene targeted for mutation in Hutchinson Gilford Progeria Syndrome, may control the onset of aging-associated decline in normal fibroblasts.
Kudlow
Brian A
BA
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Kennedy
Brian K
BK
D000367:Age Factors; D000375:Aging / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D034904:Lamin Type A / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D011371:Progeria / Q000235:genetics*
C494847:LMNA protein, human; D034904:Lamin Type A