title: Squamous cell carcinoma of the bladder: a patient treated successfully with a new combined chemotherapy regimen, intraarterial nedaplatin and pirarubicin plus intravenous methotrexate and vincristine.
abstract: We report a case of squamous cell carcinoma (SCC) of the bladder treated successfully with intraarterial chemotherapy using nedaplatin. A 75-year-old woman was admitted to our hospital in March 2004 with gross hematuria. Cystoscopic examination showed tumors on the anterior bladder wall. Computed tomography (CT) scans and magnetic resonance imaging (MRI) revealed extravesical invasion of the tumors, and a clinical diagnosis of T3bN0M0 was made. Transurethral biopsy was performed, and histopathological examination revealed SCC, grade 2-3, invasive. The patient received a new combined chemotherapy, intraarterial nedaplatin and pirarubicin plus intravenous methotrexate and vincristine. After two courses of the chemotherapy, CT scans and MRI demonstrated no tumor in the bladder. Transurethral bladder-wall biopsy was performed in November 2004, and histopathological examination of the specimen revealed no definite tumors. The patient is alive without evidence of disease more than 1 year after the chemotherapy.
authors.affiliation: Department of Urology, Ishikawa Prefectural Central Hospital, 2-1 Kuratsukihigashi, Kanazawa 920-8530, Japan. kshigehara@ipch.jp
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Shigehara
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Takao
authors.initials: T
authors.lastname: Nakashima
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shimamura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004333:Drug Administration Routes; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging; D009944:Organoplatinum Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D012074:Remission Induction / Q000379:methods; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D009944:Organoplatinum Compounds; D014750:Vincristine; D004317:Doxorubicin; C053989:nedaplatin; C027260:pirarubicin; D008727:Methotrexate