[Adipocyte signals in energy balance and digestive diseases].
For the regulation of energy balance in various internal organs including gut, pancreas and liver, visceral adipose tissue and brain perform important sensing and signaling roles via neural and endocrine pathway. Among these, adipose tissue has been known as a simple energy-storing organ, which stores excess energy in triglyceride. However, it became apparent that adipocytes have various receptors related to energy homeostasis, and secrete adipocytokines by endocrine, paracrine and autocrine mechanisms. In this review, basic roles of adipocytes in energy homeostasis and the correlation between adipocyte signals and digestive diseases are discussed.
Chun
Hoon Jai
HJ
Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea.
Keum
Bora
B
Uhm
Chang-Sub
CS
D017667:Adipocytes / Q000378:metabolism*; D054392:Adipokines / Q000502:physiology*; D052242:Adiponectin / Q000502:physiology; D004066:Digestive System Diseases / Q000378:metabolism*; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D020738:Leptin / Q000502:physiology; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology; D052243:Resistin / Q000502:physiology; D015398:Signal Transduction
D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; D047492:Peroxisome Proliferator-Activated Receptors; D052243:Resistin