Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections.
Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.
Lawlor
Matthew S
MS
Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Handley
Scott A
SA
Miller
Virginia L
VL
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D016207:Cytokines / Q000378:metabolism; D007710:Klebsiella Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D008168:Lung / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
D001426:Bacterial Proteins; D016207:Cytokines