title: Chromium(III) complexes of D-glucosaminic acid and their effect on decreasing blood sugar in vivo.
abstract: Two chromium(III) complexes of glucosaminic acid were synthesized by neutralization and exchange reaction. The formation of 1 : 1 and 2 : 3 (Cr : glucosaminate) complexes was confirmed by elemental analyses and spectroscopic studies. The effect of the complexes on decreasing blood sugar was investigated on type-2 diabetes model rats induced by tetraoxypyrimidine. The results indicated that the effect on decreasing blood sugar was comparable to that of picolinate chromium complex (Cr(pic)(3)) currently used world wide.
authors.affiliation: Coordination Chemistry Institute, The State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
authors.forename: Sheng-Ju
authors.initials: SJ
authors.lastname: Ou
authors.forename: Guang
authors.initials: G
authors.lastname: Chen
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Lin
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Bai
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Duan
authors.forename: Cai-Ping
authors.initials: CP
authors.lastname: Mao
mesh_terms: D000496:Alloxan / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D017608:Chromium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D004195:Disease Models, Animal; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D010848:Picolinic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D001786:Blood Glucose; D017608:Chromium Compounds; D010848:Picolinic Acids; C035547:glucosaminic acid; D000496:Alloxan; D005944:Glucosamine