title: Recovery of subjective visual horizontal after unilateral vestibular deafferentation by intratympanic instillation of gentamicin.
abstract: The time course of the recovery of subjective visual horizontal (SVH) after unilateral vestibular deafferentation by intratympanic instillation of gentamicin was studied. Six patients who underwent intratympanic gentamicin instillation therapy for Meniere's disease (1 man and 5 women, 32 to 69 years of age) were enrolled in this study. For comparison, SVH in 23 healthy subjects (12 men and 11 woman, 23 to 48 years of age) was also measured. The mean +/- SD of SVH in healthy subjects was 0.0 +/- 1.1 deg. All of the 6 patients showed significantly deviated SVH toward the injected side-down at the early stage after the therapy. Although one patient showed recovery of SVH to the normal range 25 days after the injection, the other patients required more time for recovery. Three patients did not show recovery to the normal range after 1 year. On the other hand, spontaneous nystagmus observed using an infrared CCD camera in total dark disappeared after 35 days (median). Patients who had normal vestibular evoked myogenic potentials before the therapy showed a tendency of delay of recovery of SVH. The reasons why the recovery of SVH took longer than the disappearance of spontaneous nystagmus are discussed in this report.
authors.affiliation: Department of Otolaryngology, University of Tokyo, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Takai
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Murofushi
authors.forename: Munetaka
authors.initials: M
authors.lastname: Ushio
authors.forename: Shinichi
authors.initials: S
authors.lastname: Iwasaki
mesh_terms: D000328:Adult; D000368:Aged; D002150:Caloric Tests / Q000379:methods; D004333:Drug Administration Routes; D004432:Ear, Middle / Q000187:drug effects*; D004584:Electronystagmography / Q000379:methods; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006309:Hearing / Q000187:drug effects; D006801:Humans; D007267:Injections / Q000379:methods; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy; D008875:Middle Aged; D017120:Nystagmus, Optokinetic / Q000187:drug effects / Q000502:physiology; D014717:Vertigo / Q000188:drug therapy*; D015837:Vestibular Diseases / Q000188:drug therapy* / Q000534:rehabilitation*; D014724:Vestibular Function Tests; D014725:Vestibular Nerve / Q000187:drug effects
chemical_list: D005839:Gentamicins