title: Non-alcoholic fatty liver disease (NAFLD)--a novel common aspect of the metabolic syndrome.
abstract: Non-alcoholic fatty liver disease (NAFLD) is emerging as one of the most common liver disorders claiming the urgent attention of both medical professionals and the public sphere because of the imminent epidemic of advanced liver injury that appendages epidemic of obesity. Recent research reveals simple triglyceride accumulation in hepatocytes (i.e., liver steatosis) frequently becoming complicated by inflammation (i.e., non-alcoholic steatohepatitis, or NASH) that may progress into more advanced stages of the disease including cirrhosis or, eventually, hepatocellular carcinoma. The exact mechanisms of the progression of NAFLD into overt NASH and advanced disease stages are largely unknown. There is urgent need in terms of both intensive research pursuits and effective practical measures to deal with this common threat.
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic. kapalinakb@centurm.cz
authors.forename: Katerina
authors.initials: K
authors.lastname: Bogdanova
authors.forename: Hana
authors.initials: H
authors.lastname: Poczatkova
authors.forename: Lenka
authors.initials: L
authors.lastname: Uherkova
authors.forename: Dagmar
authors.initials: D
authors.lastname: Riegrova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Rypka
authors.forename: Janos
authors.initials: J
authors.lastname: Feher
authors.forename: Giulio
authors.initials: G
authors.lastname: Marchesini
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Vesely
mesh_terms: D005234:Fatty Liver / Q000150:complications* / Q000628:therapy; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications*