title: Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: a spectral, antibacterial and cytotoxic study.
abstract: Some platinum (IV) complexes [Pt(L)2Cl2] [where, L=2-aminopyridine-N-thiohydrazide (L1), (2-aminopyridine-N-thio)-1,3-propanediamine (L2), benzaldehyde-2-aminopyridine-N-thiohydrazone (L3) and salicylaldehyde-2-aminopyrtidine-N-thiohydrazone (L4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. ajaykmishra1@yahoo.com
authors.forename: A K
authors.initials: AK
authors.lastname: Mishra
authors.forename: S B
authors.initials: SB
authors.lastname: Mishra
authors.forename: N
authors.initials: N
authors.lastname: Manav
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.lastname: Sharad
authors.forename: R
authors.initials: R
authors.lastname: Chandra
authors.forename: D
authors.initials: D
authors.lastname: Saluja
authors.forename: N K
authors.initials: NK
authors.lastname: Kaushik
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004583:Electrons; D006367:HeLa Cells; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013210:Staphylococcus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003959:Diamines; D006834:Hydrazines; D006835:Hydrazones; D009944:Organoplatinum Compounds