title: Direct, palladium-catalyzed, multicomponent synthesis of beta-lactams from imines, acid chloride, and carbon monoxide.
abstract: A new palladium-catalyzed synthesis of 3-amido-substituted beta-lactams is reported. This process involves the one-pot coupling of four components, imines, carbon monoxide, and acid chloride, providing a flexible route to construct this class of heterocycle. The generation of beta-lactams with two different imines can also be accomplished, providing a method to assemble these products with independent control over five separate substituents.
authors.affiliation: Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Dhawan
authors.forename: Rania D
authors.initials: RD
authors.lastname: Dghaym
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: St Cyr
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Arndtsen
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D047090:beta-Lactams / Q000138:chemical synthesis*
chemical_list: D002712:Chlorides; D007097:Imines; D047090:beta-Lactams; D010165:Palladium; D002248:Carbon Monoxide