title: Hippocampal volume in childhood complex partial seizures.
abstract: OBJECTIVE
  This study compared hippocampal volume in children with cryptogenic epilepsy, all of whom had complex partial seizures (CPS), and age and gender matched normal children controlling for between group differences in IQ and demographic variables (e.g., age, gender, ethnicity, socioeconomic status). It also examined the relationship between hippocampal volumes and seizure variables in the patients.
  
  
  METHODS
  Using quantitative magnetic resonance imaging (MRI), we compared the hippocampal volumes of 19 medically treated children with CPS, aged 6-14 years, to 21 age and gender matched normal children.
  
  
  RESULTS
  The children with CPS had significantly smaller total hippocampal volumes than the normal children. This finding was accounted for primarily by significantly smaller anterior hippocampal volumes. Within the CPS group, smaller total and posterior hippocampus volumes were significantly associated with longer duration of illness. Anterior hippocampal volumes, however, were unrelated to seizure variables.
  
  
  CONCLUSIONS
  These findings imply impaired development of the hippocampus, particularly the anterior hippocampus, and a differential effect of the underlying illness and on-going seizures on hippocampal development in medically controlled pediatric CPS.
authors.affiliation: UCLA Department of Psychiatry, Psychiatry and Biobehavioral Sciences, UCLA, Semel Institute, Rm. 48-253B, 760 Westwood Plaza, Los Angeles, CA 90095-1759, USA. mdaley@mednet.ucla.edu
authors.forename: Melita
authors.initials: M
authors.lastname: Daley
authors.forename: Derek
authors.initials: D
authors.lastname: Ott
authors.forename: Rebecca
authors.initials: R
authors.lastname: Blanton
authors.forename: Prabha
authors.initials: P
authors.lastname: Siddarth
authors.forename: Jennifer
authors.initials: J
authors.lastname: Levitt
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Mormino
authors.forename: Cornelius
authors.initials: C
authors.lastname: Hojatkashani
authors.forename: Raquel
authors.initials: R
authors.lastname: Tenorio
authors.forename: Suresh
authors.initials: S
authors.lastname: Gurbani
authors.forename: W Donald
authors.initials: WD
authors.lastname: Shields
authors.forename: Raman
authors.initials: R
authors.lastname: Sankar
authors.forename: Arthur
authors.initials: A
authors.lastname: Toga
authors.forename: Rochelle
authors.initials: R
authors.lastname: Caplan
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D017029:Epilepsy, Complex Partial / Q000208:ethnology / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007360:Intelligence; D008279:Magnetic Resonance Imaging; D008297:Male; D015999:Multivariate Analysis; D009929:Organ Size; D012959:Socioeconomic Factors