title: [Bromadiolone poisoning in foxes].
abstract: Bromadiolone is an anticoagulant rodenticide that inhibits the reactivation of vitamin K1 by the enzyme vitamin K1-epoxide reductase. The present case report originated from the application of bromadiolone against water voles (Arvicola terrestris) in northeastern Switzerland. At least 40 foxes (Vulpes vulpes) were found dead after the inappropriate use of a bait that contained 0.02 % bromadiolone. Anticoagulant rodenticide poisoning was suspected on the basis of the postmortem examination and subsequently confirmed by the detection ofbromadiolone both in the blood and in samples from thoracic and abdominal fluids.
authors.affiliation: Institut für Veterinärpharmakologie und -toxikologie der Universität Zurich. jacqueline.kupper@vetpharm.unizh.ch
authors.forename: J
authors.initials: J
authors.lastname: Kupper
authors.forename: T
authors.initials: T
authors.lastname: Grobosch
authors.forename: R
authors.initials: R
authors.lastname: Kistler
authors.forename: T
authors.initials: T
authors.lastname: Sydler
authors.forename: H
authors.initials: H
authors.lastname: Naegeli
mesh_terms: D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000818:Animals; D000925:Anticoagulants / Q000378:metabolism / Q000506:poisoning*; D005589:Foxes; D012378:Rodenticides / Q000506:poisoning*; D013045:Species Specificity; D013557:Switzerland
chemical_list: D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D012378:Rodenticides; C021636:bromadiolone