title: [Lacrimal film evaluation of patients with facial dystonia during botulinum toxin type A treatment].
abstract: OBJECTIVE
  To determine the effect of botulinum toxin injection in the eyelid on lacrimal film in patients with facial dystonia.
  
  
  METHODS
  Twenty-four patients with essential blepharospasm and hemifacial spasm were submitted to botulinum toxin injection and lacrimal film tests were performed before the application and after seven and thirty days.
  
  
  RESULTS
  There was improvement in symptoms of dry eye and rose bengal test, however, the breakup time and Schirmer's test did not show significant variation between pretreatment and after 1 month of follow-up.
  
  
  CONCLUSIONS
  The dry eye symptoms in patients with facial dystonia may be attenuated by botulinum toxin due to its possible inhibitory effect on the orbicular muscle leading to a decrease in lacrimal pump.
authors.affiliation: Departamento de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. patriciagrativol@yahoo.com.br
authors.forename: Patricia Grativol
authors.initials: PG
authors.lastname: Costa
authors.forename: Ivana Pereira
authors.initials: IP
authors.lastname: Cardoso
authors.forename: Fabio Petersen
authors.initials: FP
authors.lastname: Saraiva
authors.forename: Ana Carolina Pasquini
authors.initials: AC
authors.lastname: Raiza
authors.forename: Lílian Keiko
authors.initials: LK
authors.lastname: Tanaka
authors.forename: Suzana
authors.initials: S
authors.lastname: Matayoshi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001764:Blepharospasm / Q000150:complications / Q000188:drug therapy*; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D015352:Dry Eye Syndromes / Q000209:etiology*; D020821:Dystonic Disorders / Q000188:drug therapy; D005260:Female; D019569:Hemifacial Spasm / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D011446:Prospective Studies; D013666:Tears / Q000187:drug effects*; D013997:Time Factors
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A