title: Differential diagnosis of large periapical lesions using cone-beam computed tomography measurements and biopsy.
abstract: This study compared the differential diagnosis of large periapical lesions (granuloma versus cyst) to traditional biopsy using Cone Beam Computed Tomography (CBCT), the NewTom 3G. Large lesions were scanned and a preoperative diagnosis based on gray value measurements of the imaged lesion area was made. After surgery a biopsy report was obtained and compared to the CBCT diagnosis. In 13 out of 17 cases, the diagnosis coincided. In 4 out of 17 cases, the CBCT read cyst with the oral pathologist's diagnosis being granuloma. Thus, the CBCT may provide a more accurate diagnosis than biopsy and histology providing a diagnosis without invasive surgery and/or waiting a year to see if nonsurgical therapy is effective.
authors.affiliation: Division of Surgical Therapeutic & Bioengineering Sciences, School of Dentistry, University of Southern California, Los Angeles, CA 90089-0641, USA. simon@usc.edu
authors.forename: James H S
authors.initials: JH
authors.lastname: Simon
authors.forename: Reyes
authors.initials: R
authors.lastname: Enciso
authors.forename: Jose-Maria
authors.initials: JM
authors.lastname: Malfaz
authors.forename: Ramon
authors.initials: R
authors.lastname: Roges
authors.forename: Michelle
authors.initials: M
authors.lastname: Bailey-Perry
authors.forename: Anish
authors.initials: A
authors.lastname: Patel
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D010484:Periapical Granuloma / Q000000981:diagnostic imaging / Q000473:pathology*; D011842:Radicular Cyst / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods