Simple purification of recovered [18O]H2O by UV, ozone, and solid-phase extraction methods.
We have developed three methods for removing organic impurities as well as a solid-phase extraction (SPE) method for removing metallic and ionic impurities from recovered [18O]H2O. Preliminary experiments with [16O]H2O were used to determine the optimal purification conditions. These showed that UV irradiation rapidly (<4 h) eliminated low boiling point impurities such as acetonitrile and acetone with only a slight loss of mass. A combination of UV irradiation and purging with ozone removed high boiling point impurities such as ethanol and methanol more quickly than UV irradiation alone. UV irradiation followed by a SPE with [18O]H2O removed all organic and inorganic impurities. The purified [18O]H2O gave a saturation yield of 128.62+/-15.6 mCi/microA for [18F]fluoride and a 49.8+/-12.7% radiochemical yield for [18F]fluorodeoxyglucose.
Moon
Woo Yeon
WY
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea.
Oh
Seung Jun
SJ
Cheon
Jun Hong
JH
Chae
Won Seok
WS
Lim
Sung Jae
SJ
Cho
Si Man
SM
Moon
Dae Hyuk
DH