Envelope proteins of Jaagsiekte sheep retrovirus and enzootic nasal tumor virus induce similar bronchioalveolar tumors in lungs of mice.
Jaagsiekte sheep retrovirus (JSRV) induces bronchioalveolar tumors in sheep and goats. Expression of the JSRV envelope (Env) protein in mouse airway epithelial cells induces similar tumors, indicating that Env expression is sufficient for tissue-specific tumor formation. Enzootic nasal tumor virus (ENTV) is related to JSRV but induces tumors in the nasal epithelium of sheep and goats. Here we found that ENTV Env can also induce tumors in mice but, unexpectedly, with a phenotype identical to that of tumors induced by the JSRV Env, indicating that factors other than Env mediate the tissue specificity of tumor induction by ENTV.
Wootton
Sarah K
SK
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Room C2-105, Seattle, WA 98109-1024, USA.
Halbert
Christine L
CL
Miller
A Dusty
AD
D000818:Animals; D001980:Bronchi / Q000821:virology; D001984:Bronchial Neoplasms / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D000229:Dependovirus / Q000235:genetics; D015686:Gene Products, env / Q000737:chemistry*; D005822:Genetic Vectors; D022141:Jaagsiekte sheep retrovirus / Q000378:metabolism*; D008168:Lung / Q000821:virology*; D051379:Mice; D018345:Mice, Knockout; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D014780:Viruses / Q000378:metabolism
D004279:DNA, Viral; D015686:Gene Products, env