title: A case of hydrocortisone desensitization in a patient with radiocontrast-induced anaphylactoid reaction and corticosteroid allergy.
abstract: Allergic reactions and systemic desensitization to corticosteroids have been documented rarely in English language literature. These reactions appear more often when the agent is applied topically and may lead to dangerous complications in patients if administered i.v. Therefore, the safety and efficacy of using an i.v. corticosteroid for desensitization in a patient who has a history of allergy to corticosteroid must be weighed carefully, especially when the aim of its use is to prevent an allergic reaction from a second drug. We report a case of successful systemic hydrocortisone desensitization in a patient with radiocontrast-induced anaphylactoid reaction and corticosteroid allergy. Sensitization to corticosteroids was determined through skin testing. The patient was desensitized to hydrocortisone and premedicated with hydrocortisone and diphenhydramine and subsequently underwent cardiac catheterization with radiocontrast without adverse reaction.
authors.affiliation: Division of Clinical Immunology and Allergy, Department of Medicine, Beth Israel Medical Center, New York, New York 10003, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Lee-Wong
authors.forename: Suzanne
authors.initials: S
authors.lastname: McClelland
authors.forename: Kaman
authors.initials: K
authors.lastname: Chong
authors.forename: Evans R
authors.initials: ER
authors.lastname: Fernandez-Perez
authors.forename: Evans
authors.initials: E
authors.lastname: Fernandez
mesh_terms: D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control; D006328:Cardiac Catheterization; D003287:Contrast Media / Q000009:adverse effects*; D003888:Desensitization, Immunologic / Q000379:methods*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000628:therapy*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D005938:Glucocorticoids; D006854:Hydrocortisone