title: Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies.
abstract: With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials.
authors.affiliation: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. william.gallagher@ucd.ie
authors.forename: William M
authors.initials: WM
authors.lastname: Gallagher
authors.forename: Iseult
authors.initials: I
authors.lastname: Lynch
authors.forename: Lorcan T
authors.initials: LT
authors.lastname: Allen
authors.forename: Ian
authors.initials: I
authors.lastname: Miller
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Penney
authors.forename: Darran P
authors.initials: DP
authors.lastname: O'Connor
authors.forename: Stephen
authors.initials: S
authors.lastname: Pennington
authors.forename: Alan K
authors.initials: AK
authors.lastname: Keenan
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Dawson
mesh_terms: D001672:Biocompatible Materials; D040901:Proteomics; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D001672:Biocompatible Materials; D012333:RNA, Messenger