N-carboxamido-staurosporine and selina-4(14),7(11)-diene-8,9-diol, new metabolites from a marine Streptomyces sp.
In our screening of micro-organisms for novel bioactive natural products, a new staurosporinone, N-carboxamido-staurosporine (1c), and a new sesquiterpene, (5S,8S,9R, 10S)-selina-4(14),7(11)-diene-8,9-diol (2a), were isolated from the culture broth of the marine-derived Streptomyces sp. QD518. Their structures were determined by spectroscopic methods and by comparison of the NMR data with those of structurally related known natural products, which were isolated from the same strain.
Wu
Shao Jie
SJ
Department of Organic and Biomolecular Chemistry, University of Göttingen, Germany.
Fotso
Serge
S
Li
Fuchao
F
Qin
Song
S
Kelter
Gerhard
G
Fiebig
Heinz H
HH
Laatsch
Hartmut
H
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification; D000935:Antifungal Agents / Q000302:isolation & purification; D045744:Cell Line, Tumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C513058:N-carboxamido-staurosporine; D012717:Sesquiterpenes; C513060:selina-4(14),7(11)-diene-8,9-diol; D019311:Staurosporine