Targeting T-cell adhesion molecules for drug design.
Adhesion molecules participate in many stages of immune response; they regulate leukocyte circulation, lymphoid cell homing to tissues and inflammatory sites, migration across endothelial cells and T-cell stimulation. During T-cell immune response, adhesion molecules form a specialized junction between T-cell and the antigen presenting cell. Thus, many researchers have focused their attention on targeting adhesion molecules for developing therapeutic agents. Most of these efforts are intended to develop drugs for autoimmune and inflammatory diseases. Therapeutic agents like efalizumab and alefacept have been approved by the FDA for the treatment of inflammatory autoimmune diseases. This review focuses on some of the basic aspects and importance of adhesion molecules, recent understanding of the structure of adhesion molecules, and the targeted therapeutic agents.
Jois
Seetharama D S
SD
Department of Pharmacy, Medicinal Chemistry Program, Office of Life Sciences, National University of Singapore, Singapore 117543. jois@ulm.edu
Jining
Liu
L
Nagarajarao
Latha M
LM
D000595:Amino Acid Sequence; D000818:Animals; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000235:genetics; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology
D015815:Cell Adhesion Molecules