title: Impaired glucose tolerance: a possible contributor to left ventricular hypertrophy and diastolic dysfunction.
abstract: BACKGROUND
  Approximately 40% of patients with heart failure have preserved left ventricular systolic function with latent diastolic dysfunction associated with left ventricular hypertrophy, suggesting that diastolic dysfunction participates in the pathophysiology of heart failure. However, the cause or prerequisite status of diastolic dysfunction has not been resolved. This study was designed to investigate whether impaired glucose tolerance is related to left ventricular hypertrophy and abnormal diastolic function.
  
  
  METHODS
  An age/sex-matched study was performed in subjects who underwent health screening, including both a 75-g oral glucose tolerance test and Doppler echocardiography. Using the WHO criteria, the subjects were classified into the diabetic group (n=112, 77 men/35 women, mean aged: 57.3+/-7.6 years), the impaired glucose tolerance group (n=226, 155 men/71 women, mean aged 56.8+/-7.5 years), and the normal glucose tolerance group (n=639, 438 men/201 women, mean aged 56.7+/-7.5 years). The subjects had no symptoms or signs of chronic heart failure.
  
  
  RESULTS
  There were no significant differences of ejection fraction, fractional shortening, and left ventricular dimensions among the three groups. However left ventricular mass was larger in the impaired glucose tolerance and the diabetic groups compared with the normal group, while the mitral E/A wave ratio was lower in the impaired glucose tolerance and the diabetic groups compared with the normal group even after adjustment for the values of blood pressure and body mass index and left ventricular mass.
  
  
  CONCLUSIONS
  These results suggest that impaired glucose tolerance is a possible contributor to left ventricular hypertrophy and diastolic dysfunction.
authors.affiliation: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Asanuma
authors.forename: Jiyoong
authors.initials: J
authors.lastname: Kim
authors.forename: Yulin
authors.initials: Y
authors.lastname: Liao
authors.forename: Akio
authors.initials: A
authors.lastname: Hirata
authors.forename: Osamu
authors.initials: O
authors.lastname: Tsukamoto
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Minamino
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Moritaka
authors.initials: M
authors.lastname: Goto
authors.forename: Koichi
authors.initials: K
authors.lastname: Node
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kitakaze
mesh_terms: D000704:Analysis of Variance; D001795:Blood Pressure Determination / Q000379:methods; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D018149:Glucose Intolerance / Q000150:complications* / Q000503:physiopathology*; D005951:Glucose Tolerance Test; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged