Effect of radish (Raphanus sativus Linn.) on thyroid status under conditions of varying iodine intake in rats.
Cruciferous plants viz. cabbage, cauliflower, turnip, radish, mustard etc. that contain goitrogenic/antithyroid substances, constitute a portion of regular human diet. The effect of chronic feeding of fresh and cooked radish, R. sativus under varying state of iodine intake on morphological and functional status of thyroid in albino rats was evaluated by thyroid gland morphology and histology, thyroid peroxidase activity, serum triiodothyronine, thyroxine and thyrotropin levels. The consumption pattern of iodine and goitrogens of cyanogenic origin was evaluated by measuring urinary iodine and thiocyanate levels respectively. After chronic radish feeding, increased weight of thyroid gland, decreased thyroid peroxidase activity, reduced thyroid hormone profiles and elevated level of thyrotropin were observed resembling a relative state of hypoactive thyroid gland in comparison to control even after supplementation of adequate iodine.
Chandra
Amar K
AK
Endocrinology and Reproductive Physiology Laboratory, Department of Physiology, University of College of Science and Technology, University of Calcutta, Kolkata, India. amark_chandra@yahoo.co.in
Mukhopadhyay
Sanjukta
S
Ghosh
Dishari
D
Tripathy
Smritiratan
S
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology; D007455:Iodine / Q000008:administration & dosage* / Q000494:pharmacology* / Q000652:urine; D009929:Organ Size / Q000187:drug effects; D031224:Raphanus; D051381:Rats; D017208:Rats, Wistar; D013861:Thiocyanates / Q000652:urine; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin / Q000652:urine; D013974:Thyroxine / Q000652:urine; D014284:Triiodothyronine / Q000652:urine
D013956:Antithyroid Agents; D013861:Thiocyanates; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; C031760:thiocyanate; D013974:Thyroxine