title: Liver injury in long-term methotrexate treatment in psoriasis is relatively infrequent.
abstract: BACKGROUND
  Methotrexate-induced liver damage in psoriasis has led to dermatologic guidelines that stipulate monitoring of liver injury by means of serial liver biopsies. Recent literature data suggest that methotrexate may be considerably less hepatotoxic than previously assumed.
  
  
  OBJECTIVE
  To evaluate prevalence and development of liver injury in methotrexate treated psoriasis.
  
  
  METHODS
  Retrospective chart review (1976-2005).
  
  
  RESULTS
  Hundred and twenty-five patients (F58/M67; mean age 45.0, SD 12.7 years) received a median cumulative methotrexate dose of 2,113 mg (range 180-20 235) over a median period of 228 weeks (range 16-1763). Two hundred and seventy eight liver biopsies were analysed and 71% were classified as Roenigk grade I, 14% as Roenigk II, 14% grade IIIa, 2% grade IIIB and 2% grade IV. Liver injury was not associated with cumulative dose, weekly prescribed dose, age or duration of treatment. Obesity and diabetes were significant risk factors for liver injury. A total of 68 patients had multiple biopsies, 3% improved, 72% did not change and in 25% liver histology deteriorated. The majority of cases (84%) that progressed to Roenigk 2 had a cumulative dose of 1,500-6,000 mg.
  
  
  CONCLUSIONS
  Methotrexate-related liver injury is less frequent than previously thought and mostly occurred at cumulative dose of <6,000 mg. Diabetes and being overweight are significantly correlated with liver injury.
authors.affiliation: Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. m.berends@derma.umcn.nl
authors.forename: M A M
authors.initials: MA
authors.lastname: Berends
authors.forename: J
authors.initials: J
authors.lastname: Snoek
authors.forename: E M G J
authors.initials: EM
authors.lastname: de Jong
authors.forename: P C M
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: M G H
authors.initials: MG
authors.lastname: van Oijen
authors.forename: J H
authors.initials: JH
authors.lastname: van Krieken
authors.forename: J P H
authors.initials: JP
authors.lastname: Drenth
mesh_terms: D056486:Chemical and Drug Induced Liver Injury; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008107:Liver Diseases / Q000201:enzymology / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D028761:Withholding Treatment
chemical_list: D003879:Dermatologic Agents; D008727:Methotrexate