Translocation (10;11)(p12;q23) in childhood acute myeloid leukemia: incidence and complex mechanism.
Using both conventional and molecular cytogenetic methods, we found five new cases of t(10;11)(p12;q23). This translocation represented 28% of all cases of childhood AML treated at our center in 2004, and 63% of AML with rearrangements of 11q23. We describe three mechanisms for the translocation. Different fragments of 11q were involved in four of the five cases. One patient showed a cytogenetically cryptic insertion of 5' part of MLL into the 3' part of MLLT10 in 10p12. The median event-free survival of patients was 8.1 months, and we conclude that the t(10;11)(p12;q23) is associated with unfavorable prognosis in childhood acute myeloid leukemia.
Stasevich
Irina
I
Research Center for Pediatric Oncology and Hematology, 223040, Minsk Region, p. Lesnoi, Belarus. istasevich@yahoo.com
Utskevich
Regina
R
Kustanovich
Anatoly
A
Litvinko
Natallia
N
Savitskaya
Tatsiana
T
Chernyavskaya
Svetlana
S
Saharova
Olga
O
Aleinikova
Olga
O
D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic