Potential for discovery of neuroprotective factors in serum and tissue from hibernating species.
Hibernation is a unique phenotype displayed by a phylogenetically diverse group of organisms including several species of mammals and one species of primate. Here we review evidence for blood and tissue borne signaling molecules in hibernating animals, achievements in isolating and characterizing these molecules, and potential medicinal applications.
Ross
Austin P
AP
Institute of Arctic Biology, P.O. Box 757000, University of Alaska-Fairbanks, Fairbanks, AK 99775-7000, USA.
Drew
Kelly L
KL
D000222:Adaptation, Physiological; D000818:Animals; D006605:Hibernation / Q000502:physiology*; D008322:Mammals / Q000145:classification / Q000502:physiology*; D009414:Nerve Growth Factors / Q000032:analysis / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000032:analysis* / Q000494:pharmacology; D010949:Plasma / Q000737:chemistry*
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents