title: Apolipoprotein E epsilon4 allele is associated with vascular dementia.
abstract: OBJECTIVE
  The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study.
  
  
  METHODS
  We genotyped ApoE in 144 VaD patients and 251 controls.
  
  
  RESULTS
  VaD patients were more likely than controls to have ApoE epsilon3/epsilon4 or epsilon4/epsilon4 genotypes: 23.6% versus 15.1%, odds ratio (OR) = 1.7, p = 0.036. This association remained significant after adjustment for age, sex, hypertension and diabetes by multiple logistic regression: OR = 1.9, p = 0.030. The association of epsilon3/epsilon4 or epsilon4/epsilon4 genotypes with VaD was strong among people with hypertension (OR = 2.9, p = 0.007) or diabetes (OR = 6.5, p = 0.011). The association was absent among people without hypertension (OR = 1.1, p = 0.79) or diabetes (OR = 1.3, p = 0.43).
  
  
  CONCLUSIONS
  This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation.
authors.affiliation: Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China. lwbaum@cuhk.edu.hk
authors.forename: Larry
authors.initials: L
authors.lastname: Baum
authors.forename: Linda C W
authors.initials: LC
authors.lastname: Lam
authors.forename: Timothy
authors.initials: T
authors.lastname: Kwok
authors.forename: Jenny
authors.initials: J
authors.lastname: Lee
authors.forename: Helen F K
authors.initials: HF
authors.lastname: Chiu
authors.forename: Vincent C T
authors.initials: VC
authors.lastname: Mok
authors.forename: Adrian
authors.initials: A
authors.lastname: Wong
authors.forename: Xiangyan
authors.initials: X
authors.lastname: Chen
authors.forename: Wing Sze
authors.initials: WS
authors.lastname: Cheung
authors.forename: Chi Pui
authors.initials: CP
authors.lastname: Pang
authors.forename: Suk Ling
authors.initials: SL
authors.lastname: Ma
authors.forename: Nelson L S
authors.initials: NL
authors.lastname: Tang
authors.forename: Ka Sing
authors.initials: KS
authors.lastname: Wong
authors.forename: Ho Keung
authors.initials: HK
authors.lastname: Ng
mesh_terms: D000368:Aged; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000503:physiopathology; D004247:DNA / Q000235:genetics; D015140:Dementia, Vascular / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018570:Risk Assessment; D020521:Stroke / Q000235:genetics / Q000503:physiopathology
chemical_list: D053327:Apolipoprotein E4; D004247:DNA