Association between inflammation, lipid and hemostatic factors in patients with stable angina.
BACKGROUND
Dyslipidemia and thrombotic processes are both clearly involved in atherogenesis and its secondary complications. Moreover, inflammation has also been shown to play an important role in the pathophysiology of atherosclerosis. Our objective was to determine the association between inflammation, lipids and thrombosis in a group of patients with stable angina.


METHODS
295 patients (217 males and 78 females) with a mean age of 65.69+/-11.24 years. Levels of C-reactive protein, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, lipoprotein(a), apolipoproteins A1 and B100, fibrinogen and D-dimer were determined for each.


RESULTS
Arithmetic and geometric means of C-reactive protein in the sample were 10.7 and 1.4 mg/l, respectively. Distributing the sample by quartiles of C-reactive protein, we found a positive correlation between C-reactive protein, fibrinogen and D-dimer levels (p<0.000), and an inverse correlation for HDL cholesterol and apolipoprotein A1 (p<0.000). In multivariate analysis, fibrinogen (p<0.000) and D-dimer (p<0.01) levels were independently associated with high levels of C-reactive protein. Of the lipid factors, only apolipoprotein A1 (p<0.000) was independently and inversely associated with high levels of C-reactive protein.


CONCLUSIONS
These data confirm the association between prothrombotic and inflammatory states and suggest the anti-inflammatory effect of apolipoprotein A1.
Sagastagoitia
José D
JD
Servicio de Cardiología, Hospital de Basurto, Departamento Medicina, Universidad del País Vasco UPV/EHU, Bilbao, Spain.
Sáez
Yolanda
Y
Vacas
Marta
M
Narváez
Idoia
I
Sáez de Lafuente
Jesús P
JP
Molinero
Enrique
E
Magro
Ana
A
Lafita
Manuel
M
Santos
Mónica
M
Escobar
Antonio
A
Iriarte
José A
JA
D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000209:etiology*; D016632:Apolipoprotein A-I / Q000097:blood; D053299:Apolipoprotein B-100 / Q000097:blood; D050197:Atherosclerosis / Q000209:etiology*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005338:Fibrin Fibrinogen Degradation Products; D017270:Lipoprotein(a); D014280:Triglycerides; C036309:fibrin fragment D; D005340:Fibrinogen; D002097:C-Reactive Protein; D002784:Cholesterol