7,8-Dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes.
Incorporation of a bicyclic cytosine analogue, 3-beta-D-(2'-deoxyribofuranosyl)-7,8-dihydropyrido[2,3-d]pyrimidine, into synthetic DNA duplexes results in a greatly enhanced thermal stability (3-4 degrees C per modification) compared to the corresponding unmodified duplex.
Shibata
Takayuki
T
Centre for Chemical Biology, Department of Chemistry, Richard Roberts Building, University of Sheffield, Brook Hill, Sheffield, UK.
Buurma
Niklaas J
NJ
Brazier
John A
JA
Thompson
Peter
P
Haq
Ihtshamul
I
Williams
David M
DM
D001483:Base Sequence; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D053903:DNA Breaks, Double-Stranded; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D013816:Thermodynamics
C520055:7,8-dihydropyrido(2,3-d)pyrimidin-2-one; D001643:Bridged Bicyclo Compounds; D003596:Cytosine; D004247:DNA