title: Relationship of psychiatric history to pain reports in rheumatoid arthritis.
abstract: OBJECTIVE
  The purpose was to examine the relationship of pre-existing psychiatric history to pain reports in a cohort of persons with RA and concomitant major depression who were receiving a trial of antidepressant medication.
  
  
  METHODS
  RA patients (n = 41) with a current episode of major depression were divided into two subgroups comprised of those with a previous psychiatric history (PSY+) (n = 20) and those without a previous psychiatric history (PSY-) (n = 21). The groups were compared with regard to their responsiveness to a regimen of antidepressive medication on measures of depression, pain, coping, and life stress over a period of 15 months.
  
  
  RESULTS
  Although depression scores for both the PSY+ and the PSY- groups decreased significantly from baseline to 15-month follow-up, the composite pain score was found to be significantly decreased only for the PSY- group.
  
  
  CONCLUSIONS
  Psychiatric history appears to predispose persons with concomitant RA and major depression to report less pain reduction following antidepressive treatment than those persons without a psychiatric history.
authors.affiliation: Frazier Rehabilitation and Neurosciences Center, Louisville, Kentucky, USA.
authors.forename: Catherine G
authors.initials: CG
authors.lastname: Frantom
authors.forename: Jerry C
authors.initials: JC
authors.lastname: Parker
authors.forename: Karen L
authors.initials: KL
authors.lastname: Smarr
authors.forename: James R
authors.initials: JR
authors.lastname: Slaughter
authors.forename: James E
authors.initials: JE
authors.lastname: Hewett
authors.forename: John E
authors.initials: JE
authors.lastname: Hewett
authors.forename: Bin
authors.initials: B
authors.lastname: Ge
authors.forename: Kathleen Donovan
authors.initials: KD
authors.lastname: Hanson
authors.forename: Sara E
authors.initials: SE
authors.lastname: Walker
mesh_terms: D000223:Adaptation, Psychological; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000523:psychology*; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000150:complications* / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000523:psychology*; D016032:Randomized Controlled Trials as Topic; D013315:Stress, Psychological / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents