title: Hematopoietic cell formation in leech wound healing.
abstract: The angiogenic process in vertebrates and hirudineans has been compared. The leech Hirudo medicinalis, subjected to an angiogenic stimulus (surgical explant or cytokine treatment) responds, as a vertebrate, with the formation of an extensive network of new vessels accompanied by the production of circulating cells. The reviewed data confirm the surprising similarity between hirudinean and vertebrate processes in wound healing, and suggest that basic common events such as antigenic expressions of endothelial and hemopoietic cells, cytokine secretion and regulation as well as extracellular matrix interactions, are conserved and extended across diverse species, tissues and developmental phases.
authors.affiliation: Department of Structural and Functional Biology, University of Insubria, Via J. H. Dunant 3, 21100 Varese, Italy. annalisa.grimaldi@uninsubria.it
authors.forename: A
authors.initials: A
authors.lastname: Grimaldi
authors.forename: G
authors.initials: G
authors.lastname: Tettamanti
authors.forename: G
authors.initials: G
authors.lastname: Perletti
authors.forename: R
authors.initials: R
authors.lastname: Valvassori
authors.forename: M
authors.initials: M
authors.lastname: de Eguileor
mesh_terms: D000818:Animals; D006410:Hematopoiesis / Q000502:physiology*; D047709:Hirudo medicinalis / Q000502:physiology*; D006801:Humans; D023421:Models, Animal; D014714:Vertebrates / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*