title: Transcriptional control of pluripotency: decisions in early development.
abstract: The pathways controlling the maintenance and loss of pluripotency in cells of the early embryo regulate the formation of the tissues that will support development. Several transcription factors have been identified as being integral to the establishment and/or maintenance of pluripotency, coordinately regulating the expression of genes within pluripotent cells and acting as gene targets of these same processes. Recent advances in understanding the transcriptional regulation of these factors have revealed differences in the transcriptional complexes present within sub-populations of the pluripotent lineage and in the mechanisms regulating the loss of pluripotency on differentiation.
authors.affiliation: School of Molecular and Biomedical Science and the Australian Stem Cell Centre, University of Adelaide, Adelaide 5005, Australia.
authors.forename: Brett Vaughan
authors.initials: BV
authors.lastname: Johnson
authors.forename: Joy
authors.initials: J
authors.lastname: Rathjen
authors.forename: Peter David
authors.initials: PD
authors.lastname: Rathjen
mesh_terms: D000818:Animals; D019070:Cell Lineage; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D014157:Transcription Factors