Urinary excretion of alpha1-microglobulin and albumin in acute myocardial infarction. Correlation with plasma concentrations of troponin I and C-reactive protein.
OBJECTIVE
Microalbuminuria associated with myocardial infarction (MI) is normally ascribed to glomerular factors, but could just as well involve pathophysiological processes located in other parts of the nephron, e.g. proximal tubules where plasma albumin normally filtered through the glomerulus is almost completely reabsorbed. The aims of this study were to establish whether impaired tubular reabsorption of filtered albumin contributes to microalbuminuria during MI, and whether the urinary excretion of protein relates to plasma levels of C-reactive protein (CRP) and troponin I.


METHODS
We monitored plasma CRP and troponin I as well as the urinary excretion of albumin and alpha1-microglobulin, a low-molecular-weight plasma protein and marker of tubular proteinuria, in 18 patients with MI.


CONCLUSIONS
The urinary excretion of alpha1-microglobulin and albumin was significantly elevated in nine patients, and the urinary excretion of the two proteins correlated significantly. A decrease in tubular reabsorption of albumin may thus be at least one of the causative factors underlying microalbuminuria during MI. The plasma levels of CRP and troponin I were also significantly higher in this group of nine patients, and correlated with urinary protein excretion, suggesting an interrelationship between inflammatory response and tubular dysfunction. Extrarenal inflammatory processes seem to affect renal tubular function, thereby contributing to microalbuminuria during MI.
Holm
Jan
J
Department of Internal Medicine, County Hospital, Bornholm, Denmark. JanF@Holm.mail.dk
Ravn
Jakob
J
Ingemann Hansen
Steen
S
D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000150:complications*; D000510:Alpha-Globulins / Q000652:urine*; D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000652:urine*; D019210:Troponin I / Q000097:blood*
D000510:Alpha-Globulins; D019210:Troponin I; C016001:alpha-1-microglobulin; D002097:C-Reactive Protein