title: [Helicobacter pylori induces damage of HepG2 cells in vitro].
abstract: HepG2 cells were treated with Helicobacter pylori (Hp) at different concentrations and the cell killing and apoptosis of the cells were measured with MTT assay and Hoechst 33258 staining technique. The results showed that with the increment of cagA (+) Hp concentration, HepG2 cell killing and apoptosis rate increased in a concentration-dependent manner, but cagA (-) Hp did not significantly impacted on the proliferation and apoptosis of HepG2.
authors.affiliation: Department of Infectious Diseases, Guangdong Provincial People's Hospital, Guangzhou 510080, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Chen
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Chen
mesh_terms: D000942:Antigens, Bacterial / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology*; D001426:Bacterial Proteins / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000382:microbiology / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D016480:Helicobacter pylori / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008113:Liver Neoplasms / Q000382:microbiology / Q000473:pathology
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori