[Effect of long-term intake of Y3+ in drinking water on learning-memeory functions and growth-development of rats].
OBJECTIVE
The aim of this paper was to learn the effect of long-term intake of Y3+ in drinking water on learning-memory function and growth-development of rats.


METHODS
The rats were fed with water dissolved different level Y3+ (0, 0.534, 53.4, 5340 mg/L) for 6 months, pregnant rate, survive rate, bear rate, variety in weight were calculated, the learning-memory function was observed by step-down test.


RESULTS
The results showed that a significantly decrease in electric shock period and an increase in incubation period were observed for the low dose group, in contrast, a significantly increase in electric shock period and error times, and an decreases in weight and survive rate were observed for the high dose group.


CONCLUSIONS
Y3+ in 0.534 mg/L might improve the function of learning and memory in rats, and that Y3+ in 5340mg/L could restrain both the function of learning-memory functions and growth-development in rats.
Wu
Min-Yi
MY
Department of Biotechnology, Jinan University, Guangzhou 510632, China.
Zhang
Ping
P
Yang
Wei-Dong
WD
Liu
Jie-Sheng
JS
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects; D018812:Paternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D015019:Yttrium / Q000008:administration & dosage / Q000633:toxicity*
D015019:Yttrium