title: Effects of leg resistance training on arterial function in older men.
abstract: BACKGROUND
  Little information is available on the effect of strength training on vascular function, particularly in older people.
  
  
  OBJECTIVE
  To determine the effect of resistance training on arterial stiffness and endothelial function in older adults.
  
  
  METHODS
  Eleven healthy men (mean (SEM) age 64 (1) years) performed 12 weeks of resistance training involving knee flexion and extension (three sets a day, two days a week).
  
  
  RESULTS
  Resistance training increased maximal muscle power by 16% (p<0.0001). Arterial stiffness as assessed by aortic pulse wave velocity did not change with resistance training. Plasma concentration of nitric oxide (NO), measured as its stable end product (nitrite/nitrate), had increased (p<0.05) after resistance training (61.2 (10.4) v 39.6 (3.2) micromol/l). There was no change in plasma concentration of endothelin-1.
  
  
  CONCLUSIONS
  The results suggest that short term resistance training may increase NO production without stiffening central arteries in healthy older men.
authors.affiliation: Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan. smaeda@tara.tsukuba.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Otsuki
authors.forename: M
authors.initials: M
authors.lastname: Iemitsu
authors.forename: M
authors.initials: M
authors.lastname: Kamioka
authors.forename: J
authors.initials: J
authors.lastname: Sugawara
authors.forename: S
authors.initials: S
authors.lastname: Kuno
authors.forename: R
authors.initials: R
authors.lastname: Ajisaka
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D001158:Arteries / Q000502:physiology*; D004548:Elasticity; D019332:Endothelin-1 / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007866:Leg / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology*; D009569:Nitric Oxide / Q000097:blood; D010806:Physical Education and Training / Q000379:methods; D014655:Vascular Resistance / Q000502:physiology*
chemical_list: D019332:Endothelin-1; D009569:Nitric Oxide