title: Preparation and spectroscopic characterization of novel cyclodiphosph(V)azane of N(1)-2-pyrimidinylsulfanilamide complexes. Magnetic, thermal and biological activity studies.
abstract: Hexachlorocyclophosph(V)azane of sulfadiazine, (sulfupyrimidine) [N(1)-2-pyrimidinylsulfanilamide] (H2L1), was prepared and reacted with sulfur and glycine to give (H2L2) and (H2L3) ligands, respectively. The prepared ligands; H2L1, H2L2 and H2L3, react in 1:2 [ligands]:[metal ions] molar ratio with transition metals to give coloured complexes in a relatively good yields. The complexes were characterized using different physicochemical techniques, namely elemental analyses, IR, UV-vis, mass, 1H NMR, molar conductance, magnetic, solid reflectance and thermal analysis. The spectral data reveal that all the ligands behave as neutral bidentate ligands and coordinated to the metal ions via pyrimidine-N and enolic sulfonamide OH. The molar conductance data reveal that the complexes are non-electrolytes while UV-vis, solid reflectance and magnetic moment data have been shown that the complexes have octahedral geometry. The thermal behaviour of the complexes is studied and the thermodynamic activation parameters are calculated. The ligands and their complexes show high to moderate bactericidal activity.
authors.affiliation: Chemistry Department, Faculty of Science, Al-Azhar University (Girls), Nasr City, Cairo, Egypt. csharaby@hotmail.com
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Sharaby
authors.forename: Gehad G
authors.initials: GG
authors.lastname: Mohamed
authors.forename: M M
authors.initials: MM
authors.lastname: Omar
mesh_terms: D001419:Bacteria / Q000187:drug effects; D004553:Electric Conductivity; D005658:Fungi / Q000187:drug effects; D007700:Kinetics; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D008670:Metals / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D055672:Static Electricity; D013424:Sulfanilamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013696:Temperature; D013816:Thermodynamics; D013818:Thermogravimetry
chemical_list: D008024:Ligands; D008670:Metals; D009943:Organophosphorus Compounds; D013424:Sulfanilamides