title: C-26 and C-30 apocarotenoids from seeds of Ditaxis heterantha with antioxidant activity and protection against DNA oxidative damage.
abstract: The hexane extracts of seeds of Ditaxis heterantha afforded two new apocarotenoids whose structures corresponded to methyl 3-oxo-12'-apo-epsilon-caroten-12'-oate (1) (heteranthin) and methyl 3beta,6beta-epoxy-5beta-hydroxy-4,5-dihydro-8'-apo-epsilon-caroten-8'-oate (2) (ditaxin). Both compounds were evaluated for antioxidant activity and protection against DNA oxidative damage by using DPPH* free radical scavenging and Comet assays, respectively.
authors.affiliation: Departamento de Alimentos, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala, 11340 México, DF, Mexico.
authors.forename: María D
authors.initials: MD
authors.lastname: Méndez-Robles
authors.forename: Herry H
authors.initials: HH
authors.lastname: Permady
authors.forename: María E
authors.initials: ME
authors.lastname: Jaramillo-Flores
authors.forename: Eugenia C
authors.initials: EC
authors.lastname: Lugo-Cervantes
authors.forename: Anaberta
authors.initials: A
authors.lastname: Cardador-Martínez
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Canales-Aguirre
authors.forename: Fernando
authors.initials: F
authors.lastname: López-Dellamary
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Cerda-García-Rojas
authors.forename: Joaquín
authors.initials: J
authors.lastname: Tamariz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds; D002338:Carotenoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004249:DNA Damage; D019665:Euphorbiaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008800:Mexico; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; C513757:ditaxin; C513756:heteranthin; D002338:Carotenoids; C004931:1,1-diphenyl-2-picrylhydrazyl