title: Discovering new MAP kinase inhibitors.
abstract: The current study by Kim et al. (in this issue of Chemistry & Biology) uses a genetic approach with the yeast Schizosaccharomyces pombe to identify a highly specific inhibitor of Spc1 MAP kinase that competes with protein substrates for Spc1 interactions, but not with ATP binding.
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Room 536, 20 North Pine Street, Baltimore, MD 21201, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Shapiro
mesh_terms: D001665:Binding Sites; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012568:Schizosaccharomyces / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D047428:Protein Kinase Inhibitors; D020928:Mitogen-Activated Protein Kinases