Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor.
The microwave-assisted aromatization method has been used for the synthesis of a series of novel thieno[2,3-c]pyridines. This rapid method produces compounds in good yield within minutes in comparison with conventional heating method. The synthesized molecules have been evaluated as a potential new series of allosteric enhancers acting at the adenosine A(1) receptor. In a functional assay, one compound (3h) showed activity comparable with that of reference compound PD 81,723.
Romagnoli
Romeo
R
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, 44100 Ferrara, Italy. rmr@unife.it
Baraldi
Pier Giovanni
PG
Moorman
Allan R
AR
Iaconinoto
Maria Antonietta
MA
Carrion
Maria Dora
MD
Cara
Carlota Lopez
CL
Tabrizi
Mojgan Aghazadeh
MA
Preti
Delia
D
Fruttarolo
Francesca
F
Baker
Stephen P
SP
Varani
Katia
K
Borea
Pier Andrea
PA
D000494:Allosteric Regulation / Q000502:physiology; D008872:Microwaves; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D043682:Receptor, Adenosine A1 / Q000378:metabolism*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*
D011725:Pyridines; D043682:Receptor, Adenosine A1; D013876:Thiophenes; C075004:PD 81723