The structure and synthesis of the fungal cell wall.
The fungal cell wall is a dynamic structure that protects the cell from changes in osmotic pressure and other environmental stresses, while allowing the fungal cell to interact with its environment. The structure and biosynthesis of a fungal cell wall is unique to the fungi, and is therefore an excellent target for the development of anti-fungal drugs. The structure of the fungal cell wall and the drugs that target its biosynthesis are reviewed. Based on studies in a number of fungi, the cell wall has been shown to be primarily composed of chitin, glucans, mannans and glycoproteins. The biosynthesis of the various components of the fungal cell wall and the importance of the components in the formation of a functional cell wall, as revealed through mutational analyses, are discussed. There is strong evidence that the chitin, glucans and glycoproteins are covalently cross-linked together and that the cross-linking is a dynamic process that occurs extracellularly.
Bowman
Shaun M
SM
Department of Biological Sciences, The University at Buffalo, Buffalo, New York 14260, USA.
Free
Stephen J
SJ
D000935:Antifungal Agents / Q000494:pharmacology; D002473:Cell Wall / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D002686:Chitin / Q000737:chemistry / Q000378:metabolism; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism; D005658:Fungi / Q000187:drug effects / Q000378:metabolism*; D005936:Glucans / Q000737:chemistry / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009181:Mycoses / Q000188:drug therapy
D000935:Antifungal Agents; D005656:Fungal Proteins; D005936:Glucans; D006023:Glycoproteins; D002686:Chitin