title: Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome.
abstract: Necrolytic migratory erythema (NME) is an uncommon inflammatory dermatosis with a distinctive clinical and histological appearance. It shows irregular erythema, bullae, erosion, crusts and pigmentation. While it is typically associated with glucagonoma, some cases of NME without glucagonoma have been reported. Herein, we report a case of necrolytic migratory erythema associated with malabsorption 30 years after ileocolectomy. She presented erosive erythema with scale or partly flaccid bullae on her intergluteal cleft, buttock and extremities. Her laboratory data revealed essential amino acid deficiency and a slightly decreased serum zinc level, while her plasma glucagon level was low. With diagnosis of non-glucagonoma-associated NME with malabsorption due to short-bowel syndrome, she was treated and improved by i.v. amino acid supplement. Histological findings of NME include necrotic changes of keratinocytes in the upper epidermis, proliferation of those in the lower epidermis and inflammatory cell infiltration of upper dermis. We also examined the expression pattern of epidermal keratins (K6, K10) and Ki-67, one of the markers of proliferative activity, to assess the proliferation and differentiation of keratinocytes in a NME lesion by immunostaining. The findings with these immunostainings support the characteristics of HE-staining, and suggest hyponutrition may induce changing differentiation/proliferation of keratinocytes.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. nakashima-tky@umin.ac.jp
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nakashima
authors.forename: Mayumi
authors.initials: M
authors.lastname: Komine
authors.forename: Kiyo
authors.initials: K
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mitsui
authors.forename: Manabu
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ihn
authors.forename: Akihiko
authors.initials: A
authors.lastname: Asahina
authors.forename: Kanako
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D004890:Erythema / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology / Q000502:physiology; D007633:Keratins / Q000378:metabolism; D008875:Middle Aged; D012778:Short Bowel Syndrome / Q000150:complications*
chemical_list: D007633:Keratins