title: Improved anti-inflammatory properties for naproxen with cyclodextrin-grafted polysaccharides.
abstract: Mannan and carboxymethylcellulose, previously activated by periodate oxidation, were grafted with mono-6-butylenediamino-6-deoxy-beta-cyclodextrin derivatives by reductive alkylation in the presence of sodium borohydride. The formation of supramolecular complexes between these polymers and Naproxen was confirmed by fluorescence spectroscopy. The solubility of the drug was 3.8-4.6 fold increased in the presence of the cyclodextrin-grafted polysaccharides. The in vivo anti-inflammatory property of Naproxen was 1.7 times higher after supramolecular association with beta-cyclodextrin-branched mannan.
authors.affiliation: Center for Enzyme Technology, University of Matanzas, Matanzas, C.P. 44740, Cuba.
authors.forename: Héctor L
authors.initials: HL
authors.lastname: Ramírez
authors.forename: Roberto
authors.initials: R
authors.lastname: Cao
authors.forename: Alex
authors.initials: A
authors.lastname: Fragoso
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Torres-Labandeira
authors.forename: Amalia
authors.initials: A
authors.lastname: Dominguez
authors.forename: Etienne H
authors.initials: EH
authors.lastname: Schacht
authors.forename: Maysa
authors.initials: M
authors.lastname: Baños
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Villalonga
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002351:Carrageenan / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry*; D005453:Fluorescence; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008351:Mannans / Q000737:chemistry*; D009288:Naproxen / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D008351:Mannans; D009288:Naproxen; D002351:Carrageenan; D002266:Carboxymethylcellulose Sodium