L-Carnitine L-tartrate (LCLT) and dehydroepiandrosterone sulfate (DHEAS) affect red and white blood cells in aged Sprague-Dawley rats.
Supplementation with either L-carnitine or DHEAS was separately suggested to counteract age-related declines. However, little is known about any interactive effects of these substances, independently promoting mitochondrial energy metabolism, in older individuals. We thus studied the effects of 3 months of daily oral combined supplementation with LCLT and DHEAS on red (RBCs) and white blood cells (WBCs) in male Sprague-Dawley rats by determining RBC and WBC counts, lymphocyte proliferation and interleukin-2 (IL-2) synthesis in spleen lymphocytes after Concanavalin A (ConA) stimulation. Supplementation with LCLT in addition to DHEAS decreased RBCs and increased platelets in the blood of 25-month-old Sprague-Dawley rats, whereas supplementation with DHEAS alone shifted the balance from segmented neutrophile granulocytes to large lymphocytes in differential WBC counts. Based on these results, interactive effects of supplementation with L-carnitine and DHEAS on RBCs and platelets are suggested.
Strasser
Alois
A
Institute of Physiology, Department of Natural Sciences, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Wien, Austria. alois.strasser@va-wien.ac.at
Dedoyard
Anne
A
Lohninger
Alfred
A
Niedermüller
Hans
H
D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects*; D007376:Interleukin-2 / Q000096:biosynthesis; D007958:Leukocyte Count; D008297:Male; D010976:Platelet Count; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D013644:Tartrates / Q000494:pharmacology*
D007376:Interleukin-2; D013644:Tartrates; D019314:Dehydroepiandrosterone Sulfate; D002331:Carnitine; C029768:tartaric acid