title: The role of high-resolution computed tomography and magnetic resonance imaging in the evaluation of isolated orbital neurofibromas.
abstract: OBJECTIVE
  To analyze the imaging findings in patients diagnosed with isolated orbital neurofibromas.
  
  
  METHODS
  Retrospective observational case series.
  
  
  METHODS
  Computed tomographic (CT) and magnetic resonance imaging (MRI) findings were reviewed in five patients with orbital neurofibromas in the absence of systemic neurofibromatosis in this multicenter study. The main outcome measures were bony and soft tissue abnormalities involving the orbit and surrounding anatomic spaces.
  
  
  RESULTS
  Patient age ranged from 36 to 43 years (mean, 41 years); three patients were men and two were women. Duration of symptoms ranged from three to 20 years. Radiologic findings included intraconal and extraconal soft tissue masses in all patients, bony orbital abnormalities in three patients, and intracranial extension in two patients. In addition, MRI studies in one patient revealed the previously unreported presence of neurofibromas involving extraocular muscle.
  
  
  CONCLUSIONS
  Isolated orbital neurofibromas may present with differing radiologic appearances. The combined use of high-resolution CT and MRI may be of benefit in the preoperative diagnosis of these uncommon orbital tumors.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Won Chan
authors.initials: WC
authors.lastname: Park
authors.forename: W Abraham
authors.initials: WA
authors.lastname: White
authors.forename: John J
authors.initials: JJ
authors.lastname: Woog
authors.forename: James A
authors.initials: JA
authors.lastname: Garrity
authors.forename: Yoon-Duck
authors.initials: YD
authors.lastname: Kim
authors.forename: John
authors.initials: J
authors.lastname: Lane
authors.forename: Robert
authors.initials: R
authors.lastname: Witte
authors.forename: Dusica
authors.initials: D
authors.lastname: Babovic-Vuksanovic
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009455:Neurofibroma / Q000175:diagnosis* / Q000601:surgery; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*