[Mechanisms for survival of bacteria in oxidative stress and iron ions deficiency].
The influence of culture medium Fe2+ content on the resistance of Escherichia coli to hydroxyl radicals formed in the presence of Fe2+ and hydrogen peroxide in Fenton reaction was investigated. It was founded that a lack of Fe2+ in a culture medium increased resistance of bacteria to hydroxyl radicals but not to hydrogen peroxide. The suggestion was made that the lack of Fe2+ starts up synthesis of metabolites which inactivate hydroxyl radical or block Fe2+ ions participating in Fenton reaction. The phenomenon under study is considered to be a possible mechanism for survival of bacteria in oxidative stress and iron ions deficiency.
Sgibnev
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D003470:Culture Media; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development*; D005296:Ferrous Compounds; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000494:pharmacology; D018384:Oxidative Stress
D003470:Culture Media; D005296:Ferrous Compounds; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide