Radioactive skin bandages incorporating 32P for treatment of superficial tumors.
Radioactive bandages incorporating 32P, a high-energy beta- emitter, were prepared with an aim to have a radiation source that can be used for the treatment of superficial tumors. 32P-Chromic phosphate particles were prepared and filtered through Millipore filters. Filter incorporating 32P activity was immobilized between nitrocellulose membranes and placed on an adhesive bandage. There was no leakage of radioactivity from the bandage when tested in saline. Efficacy of the radioactive bandage for treatment of superficial tumors was tested in melanoma-bearing C57BL/6 mice. A single dose of treatment with 74 MBq 32P bandage resulted in tumor growth delay, whereas multiple dose treatment with 74 MBq 32P bandage at twice-weekly intervals resulted in complete tumor regression when treatment was started, when the tumor was merely palpable. Histology sections from the treated animals showed absence of tumor.
Pandey
Usha
U
Radiopharmaceuticals Division, Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, India.
Sarma
Haldahar Dev
HD
Ingle
Arvind Dasrath
AD
Kulloli
Basappa Shivalingappa
BS
Samuel
Grace
G
Venkatesh
Meera
M
D000287:Administration, Topical; D000818:Animals; D001458:Bandages; D004867:Equipment Design / Q000379:methods; D008545:Melanoma / Q000532:radiotherapy*; D008546:Melanoma, Experimental; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use*; D011874:Radiometry; D012878:Skin Neoplasms / Q000532:radiotherapy*; D013997:Time Factors
D010761:Phosphorus Radioisotopes