title: Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol.
abstract: Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.
authors.affiliation: Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1619, USA. basaraba@colostate.edu
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Basaraba
authors.forename: Erin E
authors.initials: EE
authors.lastname: Smith
authors.forename: Crystal A
authors.initials: CA
authors.lastname: Shanley
authors.forename: Ian M
authors.initials: IM
authors.lastname: Orme
mesh_terms: D000336:Aerosols; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D042601:Lymphatic Vessels / Q000382:microbiology* / Q000473:pathology*; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000473:pathology*
chemical_list: D000336:Aerosols