title: New surprises in genetic coding and how an ingenious experiment was almost scooped, by evolution.
abstract: In 1962, one of the most creative and cogent experiments on the protein coding problem was published. Now it has been discovered that archaebacteria had been doing a related kind of "experiment" all along. Both involve a trick: changing an amino acid that is already attached to a "correct" transfer RNA.
authors.affiliation: Department of Biochemistry and Molecular Pharmacology, Program in Cell Dynamics, University of Massachusetts Medical School, 377 Plantation St., Worcester, MA 01605, USA. thoru.pederson@umassmed.edu
authors.forename: Thoru
authors.initials: T
authors.lastname: Pederson
mesh_terms: D001105:Archaea / Q000235:genetics; D019143:Evolution, Molecular; D005815:Genetic Code; D019642:RNA, Archaeal / Q000235:genetics; D012343:RNA, Transfer / Q000235:genetics; D012345:RNA, Transfer, Amino Acid-Specific / Q000235:genetics
chemical_list: D019642:RNA, Archaeal; D012345:RNA, Transfer, Amino Acid-Specific; D012343:RNA, Transfer