In vitro activities of tritrpticin alone and in combination with other antimicrobial agents against Pseudomonas aeruginosa.
The in vitro activity of the cathelicidin tritrpticin was investigated against multidrug-resistant Pseudomonas aeruginosa. The isolates were susceptible to the peptide at concentrations of 0.50 to 8 mg/liter. Tritrpticin completely inhibits lipopolysaccharide procoagulant activity at a 10 microM concentration. Fractionary inhibitory concentration indexes (0.385, 0.312, and 0.458) demonstrated synergy between the peptide and beta-lactams.
Cirioni
Oscar
O
Clinica Malattie Infettive, Ospedali Riuniti Ancona, via Conca 71, I-60020 Ancona, Italy.
Giacometti
Andrea
A
Silvestri
Carmela
C
Della Vittoria
Agnese
A
Licci
Alberto
A
Riva
Alessandra
A
Scalise
Giorgio
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000382:microbiology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D007700:Kinetics; D008070:Lipopolysaccharides / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D008070:Lipopolysaccharides; D009842:Oligopeptides; C402895:tritrpticin