title: Surrogate markers for adverse outcomes in normotensive patients with pulmonary embolism.
abstract: BACKGROUND
  Although echocardiography has proven utility in risk stratifying normotensive patients with pulmonary embolism, echocardiography is not always available.
  
  
  OBJECTIVE
  Test if a novel panel consisting of pulse oximetry, 12-lead electrocardiography, and serum troponin T would have prognostic equivalence to echocardiography and to examine the prognostic performance of age, previous cardiopulmonary disease, D-dimer, brain natriuretic peptide, and percentage of pulmonary vascular occlusion on chest computed tomography.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Normotensive (systolic blood pressure of >100 mm Hg) emergency department and hospital inpatients with diagnosed pulmonary embolism who underwent cardiologist-interpreted echocardiography and other measurements within 15 hrs of anticoagulation.
  
  
  RESULTS
  End points were in-hospital circulatory shock or intubation, or death, recurrent pulmonary embolism, or severe cardiopulmonary disability (defined as echocardiographic evidence of severe right ventricular dysfunction with New York Heart Association class III dyspnea or 6-min walk test of <330 m) at 6-month follow-up. The two-one-sided test tested the hypothesis of equivalence with one-tailed alpha = 0.05 and Delta = 5%. Of 200 patients enrolled, data were complete for 181 (88%); 51 of 181 patients (28%) had an adverse outcome, including in-hospital complication (n = 18), death (n = 11), recurrent pulmonary embolism (n = 2), or cardiopulmonary disability (n = 20). Right ventricular dysfunction on initial echocardiogram was 61% sensitive (95% confidence interval, 46-74%) and 57% specific (48-66%). The panel was 71% sensitive (56-83%) and 62% specific (53-71%). The two-one-sided procedure demonstrated superiority of the panel to echocardiography for both sensitivity and noninferiority for specificity. No other biomarker demonstrated equivalence, noninferiority, or superiority for sensitivity and specificity.
  
  
  CONCLUSIONS
  Normotensive patients with pulmonary embolism have a high rate of severe adverse outcomes during 6-month follow-up. A panel of three widely available tests can be used to risk stratify patients with pulmonary embolism when formal echocardiography is not available.
authors.affiliation: Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Kline
authors.forename: Jackeline
authors.initials: J
authors.lastname: Hernandez-Nino
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Rose
authors.forename: H James
authors.initials: HJ
authors.lastname: Norton
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Camargo
mesh_terms: D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010092:Oximetry; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D020107:Troponin T / Q000097:blood*; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis* / Q000000981:diagnostic imaging
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D020107:Troponin T; C036309:fibrin fragment D; D020097:Natriuretic Peptide, Brain