[Clinical observation of target-controlled remifentanil infusion combined with propofol and doxapram in painless artificial abortion].
OBJECTIVE
To observe the impacts of doxapram on anesthetic efficacy and respiratory and circulatory functions during anesthesia with remifentanil given by target-controlled infusion (TCI) combined with propofol in painless artificial abortion.


METHODS
A total of 120 ASA I women requiring voluntarily painless artificial abortion were randomized into two equal groups. One group was given remifentanil by TCI at 2 ng/ml and propofol 1mg/kg (group I), and the other given remifentanil by TCI, propofol, and doxapram 0.6 mg/kg (group II). The anesthetic efficacy and respiratory and circulatory suppression during anesthesia were observed.


RESULTS
Both of the two groups showed satisfactory anesthetic efficacy with comparable the BIS values (P>0.05). No significant difference was noted in the induction time and awaking time between the two groups (P>0.05), but group I had more serious respiratory and circulatory depression than group II (P<0.05).


CONCLUSIONS
Doxapram may attenuate respiratory and circulatory depression during anesthesia with remifentanil given by TCI combined with propofol in painless artificial abortion, and provide comparable anesthetic efficacy.
Tan
Zhi-min
ZM
Department of Anesthesiology, Conghua Central Hospital, Conghua 510900, China. tanzm_526@163.com
Liu
Jian-hua
JH
Dong
Tao
T
Li
Jia-xing
JX
D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D019162:Anesthetics, Combined; D004315:Doxapram / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage*; D000077208:Remifentanil; D016896:Treatment Outcome
D019162:Anesthetics, Combined; D010880:Piperidines; D004315:Doxapram; D000077208:Remifentanil; D015742:Propofol