[In vitro study of platelet glycoprotein monoclonal antibody eluting stents].
In order to prove the feasibility of preparation of the drug-incorporated stent by immersing stent wires in the monoclonal antibody (mAb) solution, fluorescence stain and image analysis were used to evaluate the L-PLA-coated stent. Absorption was measured using a radioisotope technique after preparing the mAb-incorporated stent, and the absorption curve was determined from the absorption data. In an in vitro perfusion circuit, the antibody was eluted from the stent matrices, and the related influence factors were evaluated based on the release data.
Luo
Lai-long
LL
Bioengineering College of Chongqing University.
Wang
Gui-xue
GX
Yin
Tie-ying
TY
Luo
Shi-sui
SS
Ruan
Chang-gen
CG
Hou
Yan-bin
YB
D000042:Absorption; D000497:Alloys / Q000737:chemistry; D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000276:immunology; D054855:Drug-Eluting Stents; D006083:Graft Occlusion, Vascular / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000276:immunology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D011108:Polymers / Q000032:analysis / Q000737:chemistry; D013997:Time Factors
D000497:Alloys; D000911:Antibodies, Monoclonal; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011108:Polymers; D019344:Lactic Acid