title: In vivo reversion to the wild-type beta-lactam resistance phenotype mediated by a plasmid carrying ampR and qnrA1 in Enterobacter cloacae.
abstract: Resistance to beta-lactams and quinolones in two isogenic Enterobacter cloacae isolates was studied. One was susceptible to cefoxitin and amoxicillin-clavulanate. The other one showed its natural beta-lactam resistance pattern. Both isolates had a nonfunctional AmpR regulator. However, within the second one, the presence of a plasmid carrying ampR and qnrA1 allowed reversion to the wild-type beta-lactam resistance phenotype and decreased susceptibility to fluoroquinolones.
authors.affiliation: Servicio de Microbiología, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: González-López
authors.forename: M
authors.initials: M
authors.lastname: Sabaté
authors.forename: S
authors.initials: S
authors.lastname: Lavilla
authors.forename: M N
authors.initials: MN
authors.lastname: Larrosa
authors.forename: R M
authors.initials: RM
authors.lastname: Bartolomé
authors.forename: G
authors.initials: G
authors.lastname: Prats
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D002440:Cefoxitin / Q000494:pharmacology; D016972:Enterobacter cloacae / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction; D015363:Quinolones / Q000494:pharmacology; D018440:beta-Lactam Resistance / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D015363:Quinolones; C071526:AmpR protein, Bacteria; D002440:Cefoxitin; D019980:Amoxicillin-Potassium Clavulanate Combination