Mitochondrial respiration and reactive oxygen species in C. elegans.
A powerful approach to understanding complex processes such as aging is to study longevity in organisms that are amenable to genetic dissection. The nematode Caenorhabditis elegans represents a superb model system in which to study the effects of mitochondrial function on longevity. Several mutant strains have been identified that indicate that mitochondrial function is a major factor affecting the organism's lifespan. Taken as a group, these mutant strains indicate that metabolic rate, per se, only affects longevity indirectly. Mutations causing lowered metabolic rate potential are capable of decreasing or increasing longevity.
Sedensky
M M
MM
Department of Anesthesiology, University Hospitals and Case School of Medicine, Cleveland, OH 44106, USA.
Morgan
P G
PG
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D045303:Cytochromes b; D014450:Electron Transport Complex III / Q000235:genetics; D007506:Iron-Sulfur Proteins / Q000235:genetics; D008136:Longevity / Q000235:genetics / Q000502:physiology; D008928:Mitochondria / Q000235:genetics / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D009245:NADH Dehydrogenase / Q000235:genetics; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D011972:Receptor, Insulin / Q000235:genetics; D013385:Succinate Dehydrogenase / Q000235:genetics
C104339:CLK-1 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D007506:Iron-Sulfur Proteins; C472666:MEV-1 protein, C elegans; D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species; D045303:Cytochromes b; C443102:Isp-1 protein, Caenorhabditis elegans; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; C107483:DAF-2 protein, C elegans; D011972:Receptor, Insulin; C468009:GAS-1 protein, C elegans; D014450:Electron Transport Complex III