Synthesis of cryptothilone 1, the first cryptophycin-epothilone hybrid.
A hybrid structure was synthesized in which one portion is characteristic of a cryptophycin and a second sector bears the signature of an epothilone. The hybrid, in contrast to parent cryptophycin and epothilone systems, showed no effect on the tubulin assembly reaction.
White
James D
JD
Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA. james.white@oregonstate.edu
Smits
Helmars
H
Hamel
Ernest
E
D047630:Depsipeptides / Q000737:chemistry*; D034261:Epothilones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry*
D047630:Depsipeptides; D034261:Epothilones; D010456:Peptides, Cyclic; C520906:cryptothilone 1; C088419:cryptophycin