title: Effectiveness of autologous fibrin tissue adhesive in reducing postoperative blood loss during total hip arthroplasty: a prospective randomised study of 100 cases.
abstract: OBJECTIVE
  To evaluate the effectiveness of autologous fibrin tissue adhesive (auto-FTA) in reducing blood loss during cementless total hip arthroplasty (THA).
  
  
  METHODS
  From September 2000 to August 2001, 100 patients who predonated 400 ml of autologous blood were randomised to undergo either standard treatment with auto-FTA (auto-FTA group) or standard treatment alone (control group). The volume of postoperative blood loss and the decrease in haemoglobin level were measured. All patients were followed up for 3 years to evaluate the rate of bone ingrowth and heterotopic ossification.
  
  
  RESULTS
  The mean postoperative blood loss was 580 ml (standard deviation [SD], 240 ml) in the auto-FTA group and 810 ml (SD, 341 ml) in the control group; the difference was significant (230 ml, p<0.001). The decrease in haemoglobin concentration was 17 g/l (SD, 11 g/l) in the auto-FTA group and 22 g/l (SD, 12 g/l) in the control group. The difference was significant (5 g/l, p=0.03). The percentage of total blood loss of >1200 ml in any single patient was significantly lower in the auto-FTA group (4%) than in the control group (20%) [p=0.01].
  
  
  CONCLUSIONS
  Auto-FTA is a safe and effective means of reducing perioperative blood loss in THA.
authors.affiliation: Department of Orthopaedic Surgery, Saga University, Saga-City, Japan. seikei@post.saga-med.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Mawatari
authors.forename: T
authors.initials: T
authors.lastname: Higo
authors.forename: Y
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: M
authors.initials: M
authors.lastname: Shigematsu
authors.forename: T
authors.initials: T
authors.lastname: Hotokebuchi
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D001804:Blood Transfusion, Autologous; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D011446:Prospective Studies; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives