title: Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI.
abstract: In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0+/-1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, [corrected] and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD.
authors.affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China. zangyf@263.net
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zang
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Chao-Zhe
authors.initials: CZ
authors.lastname: Zhu
authors.forename: Qing-Jiu
authors.initials: QJ
authors.lastname: Cao
authors.forename: Man-Qiu
authors.initials: MQ
authors.lastname: Sui
authors.forename: Meng
authors.initials: M
authors.lastname: Liang
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Tian
authors.forename: Tian-Zi
authors.initials: TZ
authors.lastname: Jiang
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology* / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D019416:Head Movements / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D012146:Rest
chemical_list: D010100:Oxygen