The role of the BAFF/APRIL system on T cell function.
BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas. Yet, BAFF and a related ligand APRIL are expressed by T lymphocytes and modulate their functions. BAFF and APRIL promote T cell activation and survival. BAFF over-expression in transgenic (Tg) mice enhances T helper 1 (Thl)-driven delayed-type hypersensitivity (DTH), but inhibits T helper 2 (Th2) cell-mediated allergic airway inflammation in mice. Some of these effects are also dependent on BAFF-induced modification of the B cell compartment. Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation.
Mackay
Fabienne
F
Department of Immunology and Inflammation, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. f.mackay@garvan.org.au
Leung
Helen
H
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D053264:B-Cell Activating Factor / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D053265:B-Cell Activation Factor Receptor / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D053301:B-Cell Maturation Antigen / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D002454:Cell Differentiation; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D053303:Transmembrane Activator and CAML Interactor Protein / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000235:genetics / Q000276:immunology*
D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor; D053301:B-Cell Maturation Antigen; D018398:Homeodomain Proteins; D008222:Lymphokines; C108467:TNFRSF13B protein, human; C435926:TNFRSF13C protein, human; C114631:TNFSF13 protein, human; C505719:TNFSF13B protein, human; C486361:Tnfrsf13b protein, mouse; C486662:Tnfrsf13c protein, mouse; C491959:Tnfsf13 protein, mouse; C505720:Tnfsf13b protein, mouse; D053303:Transmembrane Activator and CAML Interactor Protein; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; C064658:RAG-1 protein