title: Heparin- induced thrombocytopenia occurring in the first trimester of pregnancy: successful treatment with lepirudin. A case report.
abstract: The management of heparin-induced thrombocytopenia (HIT) in pregnancy represents a medical challenge. The advent of new antithrombotic agents that do not cross-react with platelet factor 4 and heparin antibodies represents an important progress, and they are of utmost interest in special situations such as early pregnancy, a situation where the teratogenicity of warfarin precludes its use.
authors.affiliation: University of Padua Medical School, Padova, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Furlan
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vianello
authors.forename: Maurizio
authors.initials: M
authors.lastname: Clementi
authors.forename: Paolo
authors.initials: P
authors.lastname: Prandoni
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006493:Heparin; D006629:Hirudins; D006801:Humans; D010978:Platelet Factor 4 / Q000378:metabolism; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011994:Recombinant Proteins / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; D010978:Platelet Factor 4; D014859:Warfarin; D006493:Heparin; C083544:lepirudin