title: Unraveling the transcriptional network controlling ES cell pluripotency.
abstract: Embryonic stem cells (ES cells) are powerful tools for genetic engineering and hold significant potential for regenerative medicine. Recent work provides new insights into ES cell pluripotency and delineates separate transcriptional pathways in ES cells for maintenance of the undifferentiated state and for self-renewal.
authors.affiliation: Division of Hematology-Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Sridhar
authors.initials: S
authors.lastname: Rao
authors.forename: Stuart H
authors.initials: SH
authors.lastname: Orkin
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000502:physiology; D051379:Mice; D050814:Octamer Transcription Factor-3 / Q000502:physiology; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D034622:RNA Interference; D050791:STAT Transcription Factors / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
chemical_list: D053605:Leukemia Inhibitory Factor; D050814:Octamer Transcription Factor-3; D050791:STAT Transcription Factors