Bisindole alkaloids from myxomycetes Arcyria denudata and Arcyria obvelata.
A new bisindole sulfate (1) and arcyroxocin B (2) were isolated from wild fruiting bodies of Arcyria denudate, along with three known bisindoles (4-6). Dihydroarcyriacyanin A (3) was obtained from wild fruiting bodies of Arcyria obvelata, along with a known bisindole (7). The structures of these compounds were elucidated on the basis of spectroscopic data, and this is the first report of full characterizations of arcyroxocin B (2) and dihydroarcyriacyanin A (3). Compounds 2, 3, and 6 showed cytotoxicity against Jurkat cells.
Kamata
Kazuaki
K
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.
Suetsugu
Tomoko
T
Yamamoto
Yukinori
Y
Hayashi
Masahiko
M
Komiyama
Kanki
K
Ishibashi
Masami
M
D004354:Drug Screening Assays, Antitumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D015394:Molecular Structure; D009235:Myxomycetes / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
D026121:Indole Alkaloids; C513720:arcyriarubin 6-O-sulfate; C513718:arcyroxocin B; C513719:dihydroarcyriacyanin A