title: EBV-associated synovial lymphoma in a chronically inflamed joint in rheumatoid arthritis receiving prolonged methotrexate treatment.
abstract: A patient with longstanding rheumatoid arthritis (RA) developed swelling in a chronically inflamed knee joint while receiving prolonged methotrexate treatment. Magnetic resonance imaging and positron-emission tomography showed soft tissue swelling with intense tracer uptake. Biopsy confirmed high-grade B-cell lymphoma. He developed complete remission with rituximab plus CEOP. The role of chronic inflammation and methotrexate in the pathogenesis of lymphoma in RA was discussed.
authors.affiliation: Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. jcschim@hku.hk
authors.forename: C S
authors.initials: CS
authors.lastname: Chim
authors.forename: Y Y
authors.initials: YY
authors.lastname: Pang
authors.forename: G C
authors.initials: GC
authors.lastname: Ooi
authors.forename: M Y
authors.initials: MY
authors.lastname: Mok
authors.forename: T W
authors.initials: TW
authors.lastname: Shek
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D020031:Epstein-Barr Virus Infections / Q000139:chemically induced*; D004854:Herpesvirus 4, Human; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate