Pax5--a critical inhibitor of plasma cell fate.
Paired box protein 5 (Pax5) is essential for early B cell commitment as well as for B cell development, and continuous expression of Pax5 is required throughout the B cell lineage to maintain the functional identity of B cells. During B cell activation, Pax5 is downregulated before terminal differentiation into antibody-secreting plasma cells, and enforced expression of Pax5 prevents plasmacytic development. Recently, loss of Pax5 was shown to result in the substantial transition to a plasma cell state, demonstrating a functionally significant role for Pax5 in the regulation of terminal B cell differentiation. Here we elucidate the current understanding about the function of Pax5 as a key inhibitor of plasma cell differentiation.
Nera
K-P
KP
Turku Graduate School of Biomedical Sciences, Department of Medical Microbiology, University of Turku, Kiinamyllynkatu 13, 20500 Turku, Finland. kalle-pekka.nera@utu.fi
Lassila
O
O
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation; D002645:Chickens; D003564:Cytidine Deaminase; D043525:Cytosine Deaminase / Q000378:metabolism; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D006801:Humans; D051740:Ikaros Transcription Factor; D051379:Mice; D051757:PAX5 Transcription Factor / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D010950:Plasma Cells / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
C106285:IKZF3 protein, human; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; C497282:Pax5 protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D051740:Ikaros Transcription Factor; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D043525:Cytosine Deaminase; D003564:Cytidine Deaminase