Fluorinated nucleosides as antiviral and antitumor agents.
The synthesis of nucleosides and analogues with fluoride modifications on the surgar moiety are reviewed, and their biological activities as potential antiviral and anti-tumor agents are also discussed.
Meng
Wei-Dong
WD
College of Chemistry and Chemical Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, China.
Qing
Feng-Ling
FL
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002241:Carbohydrates; D006845:Hydrocarbons, Fluorinated; D009705:Nucleosides; D005461:Fluorine