title: Serum adiponectin, leptin and soluble leptin receptor in pre-eclampsia.
abstract: OBJECTIVE
  To delineate the changes in serum levels of adiponectin, leptin and soluble leptin receptor, and in the free leptin index in women with pre-eclampsia.
  
  
  METHODS
  Blood samples were collected from 38 pregnant women with pre-eclampsia and 42 normotensive pregnant women as controls. Serum concentrations of adiponectin, leptin and soluble leptin receptor were determined by enzyme-link immunosorbent assay and the free leptin index was calculated as the ratio of serum leptin to soluble leptin receptor for each sample.
  
  
  RESULTS
  No significant differences were observed between the groups regarding maternal age, gestational age and body mass index. Women with pre-eclampsia had significantly higher levels of serum adiponectin and leptin, and a higher free leptin index than controls (P<0.01, P<0.001 and P<0.001, respectively). There were no significant differences between the two groups in serum levels of soluble leptin receptor (P>0.05).
  
  
  CONCLUSIONS
  The study demonstrated elevated serum levels of adiponectin and leptin as well as a higher free leptin index in women with pre-eclampsia, suggesting these as important factors contributing to this complication of pregnancy.
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Donghong
authors.initials: D
authors.lastname: Lu
authors.forename: Xiaofu
authors.initials: X
authors.lastname: Yang
authors.forename: Yuzhong
authors.initials: Y
authors.lastname: Wu
authors.forename: Hanzhi
authors.initials: H
authors.lastname: Wang
authors.forename: Hefeng
authors.initials: H
authors.lastname: Huang
authors.forename: Minyue
authors.initials: M
authors.lastname: Dong
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000097:blood*; D054411:Receptors, Leptin
chemical_list: D052242:Adiponectin; C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin