Somatotopy of anterior cingulate cortex (ACC) and supplementary motor area (SMA) for electric stimulation of the median and tibial nerves: an fMRI study.
In this study, we tested whether there is a somatotopic sensory organization in human anterior cingulate cortex (ACC) and supplementary motor area (SMA), as a reflection of central feed-back sensory processing for motor control. To this aim, fMRI recordings were performed in 15 normal young adults during nonpainful and painful electric stimulation of median nerve at the wrist and tibial nerve at the medial malleolus. Results showed that the representation of median nerve area was more anterior in the ACC and more inferior in the SMA than the one of tibial nerve area. This was true for both nonpainful and painful stimulation intensities. These results point to a somatotopic sensory organization of human ACC and SMA.
Arienzo
D
D
Department of Clinical Sciences and Bioimaging, G. D'Annunzio University, Chieti, Italy. danarienz@yahoo.it
Babiloni
C
C
Ferretti
A
A
Caulo
M
M
Del Gratta
C
C
Tartaro
A
A
Rossini
P M
PM
Romani
G L
GL
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D004558:Electric Stimulation; D005246:Feedback; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008475:Median Nerve / Q000502:physiology*; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology*; D010146:Pain / Q000503:physiopathology; D013979:Tibial Nerve / Q000502:physiology*