title: Cryptic and complex chromosomal rearrangements and the deletion of TP53 gene in a patient with leukemic mantle cell lymphoma.
abstract: We present a case of leukemic mantle cell lymphoma with cryptic and complex chromosomal rearrangements, including multiple-way translocations involving chromosomes 8q24, 14q11/q32, 17p13.3, 17p13.1, 21q22, and 21q22; a deletion of the long arm of chromosome 10 [del(10)(q24)]; and a deletion of the TP53 gene in addition to t(11;14). We speculate that this series of chromosomal changes may disrupt the IgH gene, activate the c-MYC oncogene, inactivate the p53 tumor suppressor gene, and disrupt other cancer-related genes either within or flanking the chromosomal breakpoints. This combinational effect causes the progression of mantle cell lymphoma.
authors.affiliation: Department of Pediatrics, The University of Oklahoma Health Sciences Center, 941 Stanton L. Young Blvd., BSEB 224, Oklahoma City, OK 73104, USA.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhang
authors.forename: Williams F
authors.initials: WF
authors.lastname: Kern
authors.forename: Zongxing
authors.initials: Z
authors.lastname: Yu
authors.forename: John J
authors.initials: JJ
authors.lastname: Mulvihill
authors.forename: Shibo
authors.initials: S
authors.lastname: Li
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D016158:Genes, p53; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic