title: In vivo intraaneurysmal pressure measurements in experimental lateral wall aneurysms before and after onyx embolization.
abstract: BACKGROUND
  The aim of this study is to measure and compare the in vivo intraaneurysmal pressures of experimental lateral wall aneurysms, before and after onyx embolization. The data of this experiment will carry an important role in forming the scientific basis for the clinical endovascular applications.
  
  
  METHODS
  Five experimental lateral wall aneurysms were created by microsurgical techniques in 5 New Zealand rabbits' right common carotid arteries. Onyx embolization was applied to the aneurysms. Intraaneurysmal dome pressure and parent artery measurements before and after the procedure were recorded.
  
  
  RESULTS
  The mean arterial pressure recording in parent artery was 69.2 +/- 2.588 mm Hg under anesthesia. Mean heart rate was 131 beats per minute. The values were in physiologic limits. Meanwhile, aneurysm intradomal pressure recording showed a mean value of 59.2 +/- 5.069 mm Hg. Although there was incomplete occlusion of the aneurysm, intradomal mean pressure was recorded to be 24.4 +/- 8.876 mm Hg. After complete occlusion by onyx, mean intradomal aneurysm pressure was found to be 1.8 +/- 0.836 mm Hg.
  
  
  CONCLUSIONS
  This study is the first study reporting on intraaneurysmal pressure measurements before and after onyx embolization. The results in this experiment tend to show the adequate intraaneurysmal pressure control of onyx. This is important in the stabilization of the aneurysm to prevent rupture and rerupture. When compared with the findings of GDC coil, onyx embolization seems to be superior in intraaneurysmal pressure control.
  
  
  CONCLUSIONS
  In this study, it has been shown that onyx embolization decreases the intradomal aneurysmal pressure effectively.
authors.affiliation: Department of Neurosurgery, Pamukkale University, Denizli 35340, Turkey. feridunacar@yahoo.com
authors.forename: Feridun
authors.initials: F
authors.lastname: Acar
authors.forename: Suleyman
authors.initials: S
authors.lastname: Men
authors.forename: Volkan
authors.initials: V
authors.lastname: Tayfur
authors.forename: Osman
authors.initials: O
authors.lastname: Yilmaz
authors.forename: Serhat
authors.initials: S
authors.lastname: Erbayraktar
authors.forename: E
authors.initials: E
authors.lastname: Metin Güner
mesh_terms: D017542:Aneurysm, Ruptured / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D017536:Carotid Artery, Common / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000502:physiology; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000379:methods*; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D019586:Intracranial Hypertension / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D011145:Polyvinyls / Q000627:therapeutic use; D011817:Rabbits; D013314:Stress, Mechanical; D016896:Treatment Outcome
chemical_list: C450660:Onyx copolymer; D011145:Polyvinyls; D004121:Dimethyl Sulfoxide