title: Clinical value of pre-and postoperative 18F-FDG PET/CT in patients undergoing liver transplantation for hepatocellular carcinoma.
abstract: OBJECTIVE
  To assess the clinical value of fluorine-18-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron-emission tomography/computed tomography (PET/CT) in preoperative evaluation of hepatocellular carcinoma (HCC) patients for liver transplantation and in early detection of recurrent foci after the operation.
  
  
  METHODS
  A retrospective study was conducted involving 19 HCC patients undergoing (18)F-FDG PET/CT before and after liver transplantation. The pre- and postoperative clinical data and (18)F-FDG PET/CT images of these patients were analyzed. Totally 10 (18)F-FDG PET/CT examinations (in 8 patients) were performed for purpose of preoperative evaluation of the transplantation and assessment of the tumor elimination and general metastasis following the adjuvant therapy, and 22 examinations (in 11 patients) performed postoperatively to identify recurrent foci and metastasis. The average time span between (18)F-FDG PET/CT examination and the operations was 8.68 months.
  
  
  RESULTS
  PET examinations in 2 patients for preoperative evaluations showed no evidence of tumor recurrence or metastasis, so they underwent liver transplantation as scheduled. (18)F-FDG PET/CT found distinct metastasis in the target operation area in another 2 patients, and liver transplantation was performed with proper management of the metastatic foci. The other 4 patients were found to have distal metastasis, so that operations were cancelled and the patients received interventional therapy and other treatments instead. Postoperative (18)F-FDG PET/CT examination discovered no metastatic foci in 2 patients, but detected mycotic brain abscess in 1 patient. Another 19 postoperative (18)F-FDG PET/CT examinations (in 8 patients) showed recurrence in the grafted liver (in 4 patients), tumor embolism in the left and right hepatic veins and in the inferior vena cava, in addition to metastasis to the lungs, lymph nodes, bone, spleen, parietal pleura, intervertebral foramen of the thoracic vertebra etc.
  
  
  CONCLUSIONS
  (18)F-FDG PET/CT scanning shows superior accuracy in identification of lymph node tumor metastasis. With the advantages of whole-body scanning and high sensitivity of tumor detection, (18)F-FDG PET/CT can be instrumental in preoperative evaluation of liver transplantation for HCC (such as modification of the clinical staging) and postoperative early detection of recurrent tumors.
authors.affiliation: Department of PET Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. 71lu@163.com
authors.forename: Xin-lu
authors.initials: XL
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Quan-shi
authors.initials: QS
authors.lastname: Wang
authors.forename: Xue-lin
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000601:surgery*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000517:prevention & control; D019990:Perioperative Care; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed
chemical_list: D019788:Fluorodeoxyglucose F18