Reassignment of the configuration of salvianolic acid B and establishment of its identity with lithospermic acid B.
Salvianolic acid B and lithospermic acid B are the major components of Salvia miltiorrhiza, which is one of the most popular herbal traditional medicines in Asian countries. Salvianolic acid B and lithospermic acid B are reported to have identical structures except for the configurational assignments of two stereocenters. Through chemical correlation between a degradation product of salvianolic acid B and synthetic material, the absolute configuration of salvianolic acid B has been corrected to establish that salvianolic acid B and lithospermic acid B are in fact the same compound.
Watzke
Anja
A
Department of Chemistry, University of California-Berkeley, Berkeley, California 94720, USA.
O'Malley
Steven J
SJ
Bergman
Robert G
RG
Ellman
Jonathan A
JA
D001572:Benzofurans / Q000737:chemistry*; D053630:Depsides; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry
D001572:Benzofurans; D053630:Depsides; C076944:salvianolic acid B