title: Immunological effects of recombinant feline interferon-omega (KT-80) administration in the dog.
abstract: The immunological effects of recombinant feline interferon-omega (rFeIFN-omega ; KT-80, Toray) were examined on administration to healthy dogs. The activities of whole blood cells, macrophages, and natural killer cells were enhanced. Moreover, the whole blood activity was examined when KT-80 was administered to dogs which had been diagnosed as having natural canine parvovirus (CPV) infection. Only some cases in which the activity increased until 3 hr post-administration survived. These results suggest that rFeIFN-omega (KT-80) treatment enhanced the cellular immunity of normal dogs, and could exert significant therapeutic effects on only natural CPV infected dogs with induced continuous immunoenhancement.
authors.affiliation: Department of Veterinary Radiology, College of Bioresource Science, Nihon University, Fujisawa, Kanagawa Japan. kuwabara@bru.nihon-u.ac.jp
authors.forename: Masato
authors.initials: M
authors.lastname: Kuwabara
authors.forename: Youko
authors.initials: Y
authors.lastname: Nariai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Horiuchi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Yu
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Eriko
authors.initials: E
authors.lastname: Horioka
authors.forename: Mikiko
authors.initials: M
authors.lastname: Kawanabe
authors.forename: Takuya
authors.initials: T
authors.lastname: Kubo
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yukawa
authors.forename: Takeo
authors.initials: T
authors.lastname: Sakai
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000276:immunology; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy / Q000276:immunology; D004285:Dogs; D007111:Immunity, Cellular / Q000187:drug effects*; D007370:Interferon Type I / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D010322:Parvoviridae Infections / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D017993:Parvovirus, Canine / Q000187:drug effects; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins; C063743:interferon omega 1