title: Autoimmune thyroid encephalopathy presenting with epilepsia partialis continua.
abstract: We report the first case of an autoimmune thyroid encephalopathy presenting with multifocal motor status epilepticus. A 37-year-old female patient was admitted with multifocal motor seizures intractable to intravenous status epilepticus treatments, asymmetrical quadriparesis, truncal ataxia and continuous semi-rhythmical jerks. Pathological signal alterations were detected in both precentral cortices in MRI examination. Autoimmune thyroiditis was diagnosed after radiological examinations of the thyroid gland and thyroid function tests. Seizures promptly ceased following intravenous steroid treatment. Immunohistochemistry studies showed mild to moderate neuronal staining with the plasma and CSF samples. Remarkably, autoimmune thyroiditis may present with migrating focal motor status epilepticus. We recommend anti-thyroid antibody screening for multifocal motor status epilepticus cases of unspecified cause.
authors.affiliation: Department of Neurology, Istanbul University, Istanbul, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Aydin-Ozemir
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
authors.forename: Betül
authors.initials: B
authors.lastname: Baykan
authors.forename: Gülşen
authors.initials: G
authors.lastname: Akman-Demir
authors.forename: Neşe
authors.initials: N
authors.lastname: Ozbey
authors.forename: Candan
authors.initials: C
authors.lastname: Gürses
authors.forename: Premkumar
authors.initials: P
authors.lastname: Christadoss
authors.forename: Ayşen
authors.initials: A
authors.lastname: Gökyiğit
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004660:Encephalitis / Q000150:complications* / Q000175:diagnosis*; D017036:Epilepsia Partialis Continua / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000175:diagnosis; D050031:Hashimoto Disease / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D035583:Rare Diseases / Q000150:complications / Q000175:diagnosis