title: Serologic evidence for effective production of cytolysin A in Salmonella enterica serovars typhi and paratyphi A during human infection.
abstract: ClyASTy and ClyASPaA are closely related pore-forming cytolysins of Salmonella enterica serovars Typhi and Paratyphi A whose expression is strongly repressed under standard in vitro growth conditions. We show here that human infections by these pathogens cause a specific antibody response to ClyA, indicating effective toxin production during infection.
authors.affiliation: Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: von Rhein
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Hunfeld
authors.forename: Albrecht
authors.initials: A
authors.lastname: Ludwig
mesh_terms: D003603:Cytotoxins / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D006801:Humans; D010284:Paratyphoid Fever / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D012482:Salmonella paratyphi A / Q000276:immunology / Q000502:physiology*; D012485:Salmonella typhi / Q000276:immunology / Q000502:physiology*; D013045:Species Specificity; D014435:Typhoid Fever / Q000097:blood / Q000276:immunology / Q000378:metabolism*
chemical_list: D003603:Cytotoxins