Successful treatment of visceral leishmaniasis with liposomal amphotericin B.
We report a case of a 26-year-old female from Kenya who suffered from intermittent fever of unknown origin for one month. The major findings on admission were pancytopenia associated with considerable splenomegaly. The diagnosis was established by visualisation of amastigotes in bone marrow biopsy and by detection of antibodies to Leishmania spp. in blood. The infection was treated intravenously with liposomal amphotericin B for five days. The patient was afebrile after the first infusion. No relapse was reported.
Lagler
Heimo
H
Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy, Medical University of Vienna, Austria.
Matt
Ulrich
U
Sillaber
Christian
C
Winkler
Stefan
S
Graninger
Wolfgang
W
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001317:Austria; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007630:Kenya / Q000208:ethnology; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008081:Liposomes; D012074:Remission Induction
D000981:Antiprotozoal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B