[Epigenetic modification in human leukemia].
Epigenetic modification, which involve DNA methylation, RNA-associated silencing and histone modification, is implicated in cell proliferation, differentiation, survival, apoptosis and malignant transformation. Some leukemogenesis has been shown to be aberrance of epigenetic modification. This paper discussed the potential causes of some of leukemias correlating with the methylation of cell cycle regulation genes, small interference RNA and modification abnormality of histone after translation. The study on epigenetic modification abnormality of leukemia cells provides a new strategy for treatment of leukemia.
Chen
Yan
Y
Li
Xin-Gang
XG
D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020868:Gene Silencing; D006657:Histones; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D034741:RNA, Small Interfering / Q000235:genetics
D006657:Histones; D034741:RNA, Small Interfering