title: New methodology toward chiral, non-racemic 2,5-cis-substituted piperidines via Suzuki cross-coupling.
abstract: 1,2,3,4-Tetrahydropyridines were halogenated upon treatment with iodine to obtain the desired cross-coupling precursors. Diastereoselective hydrogenation of Suzuki cross-coupling adducts allowed the facile asymmetric synthesis of 2,5-cis-substituted piperidines in five steps from readily available pyridine.
authors.affiliation: Département de Chimie, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Larivée
authors.forename: André B
authors.initials: AB
authors.lastname: Charette