Fracture Risk (FRISK) Score: Geelong Osteoporosis Study.
OBJECTIVE
To develop and evaluate a fracture risk (FRISK) score based on multiple-site bone mineral density (BMD) measurements and other risk factors, to enable prediction of future fracture occurrence.


METHODS
All participants gave written informed consent, and the study was approved by the Barwon Health Research and Ethics Advisory Committee. BMD was measured at the femoral neck and spine in two concurrently recruited groups: women 60 years of age or older who had sustained a low-trauma fracture of the hip, spine, humerus or distal forearm during a 2-year ascertainment period (n = 231; mean age, 74 years +/- 7 [standard deviation]) and a population-based random sample of women who had not sustained a fracture during the recruitment period (n = 448; mean age, 72 years +/- 8). Falls in the previous year and the number of self-reported fractures in adult life were recorded. Coefficients of a multiple logistic regression model were used as weightings for a combined model. A longitudinal population-based sample was used to assess the fracture risk equation (n = 600; median age, 74 years; interquartile range, 67-82 years).


RESULTS
The FRISK score was obtained from the following equation: 9.304 - 4.735BMD(SP) - 4.530BMD(FN) + 1.127FS + 0.344NPF + 0.037W, where BMD(SP) is spinal BMD (in grams per square centimeter), BMD(FN) is femoral neck BMD, FS is falls score, NPF is number of previous fractures, and W is weight (in kilograms). The FRISK score successfully predicted 75% of fractures 2 years after baseline measurements in subjects in the longitudinal study with 68% specificity.


CONCLUSIONS
This study resulted in the derivation of a fracture risk score that successfully predicted 75% of fractures 2 years after baseline.
Henry
Margaret Joy
MJ
Department of Clinical and Biomedical Sciences, the University of Melbourne, Barwon Health, PO Box 281, Geelong 3220, Victoria, Australia. margh@BarwonHealth.org.au
Pasco
Julie Anne
JA
Sanders
Kerrie Margaret
KM
Nicholson
Geoffrey Charles
GC
Kotowicz
Mark Anthony
MA
D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D050723:Fractures, Bone / Q000209:etiology*; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008875:Middle Aged; D015233:Models, Statistical; D010024:Osteoporosis / Q000175:diagnosis*; D012307:Risk Factors