title: Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor.
abstract: The microwave-assisted aromatization method has been used for the synthesis of a series of novel thieno[2,3-c]pyridines. This rapid method produces compounds in good yield within minutes in comparison with conventional heating method. The synthesized molecules have been evaluated as a potential new series of allosteric enhancers acting at the adenosine A(1) receptor. In a functional assay, one compound (3h) showed activity comparable with that of reference compound PD 81,723.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Ferrara, 44100 Ferrara, Italy. rmr@unife.it
authors.forename: Romeo
authors.initials: R
authors.lastname: Romagnoli
authors.forename: Pier Giovanni
authors.initials: PG
authors.lastname: Baraldi
authors.forename: Allan R
authors.initials: AR
authors.lastname: Moorman
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Iaconinoto
authors.forename: Maria Dora
authors.initials: MD
authors.lastname: Carrion
authors.forename: Carlota Lopez
authors.initials: CL
authors.lastname: Cara
authors.forename: Mojgan Aghazadeh
authors.initials: MA
authors.lastname: Tabrizi
authors.forename: Delia
authors.initials: D
authors.lastname: Preti
authors.forename: Francesca
authors.initials: F
authors.lastname: Fruttarolo
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Baker
authors.forename: Katia
authors.initials: K
authors.lastname: Varani
authors.forename: Pier Andrea
authors.initials: PA
authors.lastname: Borea
mesh_terms: D000494:Allosteric Regulation / Q000502:physiology; D008872:Microwaves; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D043682:Receptor, Adenosine A1 / Q000378:metabolism*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D011725:Pyridines; D043682:Receptor, Adenosine A1; D013876:Thiophenes; C075004:PD 81723