title: Comparison of the host responses to wild-type and cpsB mutant Klebsiella pneumoniae infections.
abstract: Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Lawlor
authors.forename: Scott A
authors.initials: SA
authors.lastname: Handley
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Miller
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D016207:Cytokines / Q000378:metabolism; D007710:Klebsiella Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D008168:Lung / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D001426:Bacterial Proteins; D016207:Cytokines