title: Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence.
abstract: Repression of virulence by Staphylococcus aureus strains from different Agr groups has been demonstrated in vitro and is proposed as a means of competitive interference. Here, using the insect Manduca sexta, we show for the first time that this interference also occurs in vivo within a mixed population.
authors.affiliation: Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
authors.forename: Vicki
authors.initials: V
authors.lastname: Fleming
authors.forename: Ed
authors.initials: E
authors.lastname: Feil
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Sewell
authors.forename: Nicholas
authors.initials: N
authors.lastname: Day
authors.forename: Angus
authors.initials: A
authors.lastname: Buckling
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Massey
mesh_terms: D000818:Animals; D000898:Antibiosis; D001426:Bacterial Proteins / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D018402:Manduca / Q000382:microbiology*; D023421:Models, Animal; D013211:Staphylococcus aureus / Q000254:growth & development* / Q000472:pathogenicity*; D015534:Trans-Activators / Q000502:physiology*; D014774:Virulence / Q000502:physiology*
chemical_list: C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; D015534:Trans-Activators