title: A comparison of the HUPO Brain Proteome Project pilot with other proteomics studies.
abstract: The pilot phase of the Brain Proteome Project (BPP), the Human Proteome Organization (HUPO) initiative that focuses on studies of the brain of both humans and mice, has now been completed. Participating laboratories studied the proteomes of two human samples derived from biopsy and autopsy as well as three mouse samples from various developmental stages. With the combined and centrally reprocessed data now available, a comparison in terms of protein identifications and project organization is made between the HUPO BPP pilot and three other proteomics studies: the HUPO Plasma Proteome Project (PPP) pilot, a proteome of human blood platelets and a recently published comprehensive mouse proteome. Finally, as any comparison between large-scale proteomics datasets is decidedly non-trivial, we also evaluate and discuss several ways to go about comparing such different result sets.
authors.affiliation: Department of Biochemistry and Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, Ghent University, Ghent, Belgium. lennart.martens@UGent.be
authors.forename: Lennart
authors.initials: L
authors.lastname: Martens
authors.forename: Michael
authors.initials: M
authors.lastname: Müller
authors.forename: Christian
authors.initials: C
authors.lastname: Stephan
authors.forename: Michael
authors.initials: M
authors.lastname: Hamacher
authors.forename: Kai A
authors.initials: KA
authors.lastname: Reidegeld
authors.forename: Helmut E
authors.initials: HE
authors.lastname: Meyer
authors.forename: Martin
authors.initials: M
authors.lastname: Blüggel
authors.forename: Joël
authors.initials: J
authors.lastname: Vandekerckhove
authors.forename: Kris
authors.initials: K
authors.lastname: Gevaert
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D030562:Databases, Protein; D006801:Humans; D051379:Mice; D010865:Pilot Projects