RecQ helicases: lessons from model organisms.
RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication, and that proteins involved in the S-phase checkpoint are a principal defence against such instability. Cells that lack functional RecQ helicases exhibit phenotypes consistent with an inability to fully resume replication fork progress after encountering DNA damage or fork arrest. In this review we will concentrate on the various functions of RecQ helicases during S phase in model organisms.
Cobb
Jennifer A
JA
Frontiers in Genetics NCCR Program, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland. Jennifer.Cobb@molbio.unige.ch
Bjergbaek
Lotte
L
D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004265:DNA Helicases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D042822:Genomic Instability / Q000502:physiology*; D006801:Humans; D009154:Mutation; D017434:Protein Structure, Tertiary / Q000502:physiology*; D053484:RecQ Helicases; D016196:S Phase / Q000502:physiology
D000251:Adenosine Triphosphatases; C506725:RECQL protein, human; D004265:DNA Helicases; D053484:RecQ Helicases