title: Multiscale processing of mass spectrometry data.
abstract: This work addresses the problem of extracting signal content from protein mass spectrometry data. A multiscale decomposition of these spectra is used to focus on local scale-based structure by defining scale-specific features. Quantification of features is accompanied by an efficient method for calculating the location of features which avoids estimation of signal-to-noise ratios or bandwidths. Scale-based histograms serve as spectral-density-like functions indicating the regions of high density of features in the data. These regions provide bins within which features are quantified and compared across samples. As a preliminary step, the locations of prominent features within coarse-scale bins may be used for a crude registration of spectra. The multiscale decomposition, the scale-based feature definition, the calculation of feature locations, and subsequent quantification of features are carried out by way of a translation-invariant wavelet analysis.
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA. trandolp@u.washington.edu
authors.forename: T W
authors.initials: TW
authors.lastname: Randolph
authors.forename: Y
authors.initials: Y
authors.lastname: Yasui
mesh_terms: D000465:Algorithms; D001699:Biometry; D003627:Data Interpretation, Statistical; D013058:Mass Spectrometry / Q000706:statistics & numerical data*; D015233:Models, Statistical; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000706:statistics & numerical data
chemical_list: D011506:Proteins