title: Chemoradiotherapy in patients with anal cancer: impact of length of unplanned treatment interruption on outcome.
abstract: The aim of this retrospective analysis was to evaluate feasibility and effectiveness of definitive chemoradiotherapy without split-course technique in anal cancer patients. From 1993 to 2003, 81 patients were treated; 13 were excluded due to various chemotherapeutic regimes, thus 68 patients were analysed. In case of acute grade 3 toxicities, treatment was halted until improvement or resolution independent of dose. Short interruption was defined as completing treatment without exceeding eight cumulative treatment days beyond scheduled plan, other patients were considered to have had prolonged interruption. Median follow-up was 46 months. Median overall treatment time was 53 days corresponding to an interruption of eight cumulative treatment days. Thirty-five patients (51%) had treatment interruption of <or=8 days. No acute grade 4 toxicities were observed; one fatality occurred during treatment due to ileus-like symptoms according to acute grade 5 toxicity. Comparing patients with short vs. prolonged interruption 5-year actuarial rates for local control were 85% vs. 81% (p = 0.605) and for colostomy-free survival 85% vs. 87% (p = 0.762), respectively. Chemoradiotherapy with short individualised treatment interruptions seems to be feasible with acceptable acute or late toxicities. Treatment is highly effective in terms of local control and colostomy-free survival.
authors.affiliation: Department of Radiation Oncology, Medical School Hannover, Hannover, Germany. andie.meyer@gmx.net
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyer
authors.forename: Jürgen
authors.initials: J
authors.lastname: Meier Zu Eissen
authors.forename: Johann H
authors.initials: JH
authors.lastname: Karstens
authors.forename: Michael
authors.initials: M
authors.lastname: Bremer
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D019583:Dose Fractionation, Radiation; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012673:Semustine / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012673:Semustine; D003520:Cyclophosphamide; D008558:Melphalan; D005472:Fluorouracil