Silent spread of H5N1 in vaccinated poultry.
International debate on the merits of vaccinating poultry against the H5N1 influenza A virus has raised concerns about the possibility of an increased risk of between-flock transmission before outbreaks are detected. Here we show that this 'silent spread' can occur because of incomplete protection at the flock level, even if a vaccine is effective in individual birds. The use of unvaccinated sentinels can mitigate, although not completely eliminate, the problem.
Savill
Nicholas J
NJ
Centre for Infectious Diseases, University of Edinburgh, Ashworth Laboratories, The King's Buildings, Edinburgh EH9 3JT, UK. nick.savill@ed.ac.uk
St Rose
Suzanne G
SG
Keeling
Matthew J
MJ
Woolhouse
Mark E J
ME
D000818:Animals; D002645:Chickens / Q000276:immunology / Q000821:virology; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology / Q000502:physiology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D005585:Influenza in Birds / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission* / Q000821:virology; D018571:Sentinel Surveillance
D007252:Influenza Vaccines