Transcription factors of beta-cell differentiation and maturation in isolated human islets: effects of high glucose, high free fatty acids and type 2 diabetes.
Lupi
Roberto
R
Bugliani
Marco
M
Del Guerra
Silvia
S
Del Prato
Stefano
S
Marchetti
Piero
P
Boggi
Ugo
U
Filipponi
Franco
F
Mosca
Franco
F
D000368:Aged; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D051541:Hepatocyte Nuclear Factor 3-alpha / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007515:Islets of Langerhans / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D051761:Paired Box Transcription Factors / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D014157:Transcription Factors / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D005230:Fatty Acids, Nonesterified; D005947:Glucose; D051541:Hepatocyte Nuclear Factor 3-alpha; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D051761:Paired Box Transcription Factors; D012333:RNA, Messenger; D014157:Transcription Factors; C496499:FOXA1 protein, human; C093970:NEUROD1 protein, human; C498695:NEUROG3 protein, human; C105201:NKX6-1 protein, human; C491709:PAX4 protein, human