Does naloxone alone increase resuscitation rate during cardiopulmonary resuscitation in a rat asphyxia model?
Cardiac arrest was induced with asphyxia to identify if naloxone alone increases resuscitation rate during cardiopulmonary resuscitation in a rat asphyxia model. The animals were randomized into either a saline group (Sal-gro, treated with normal saline 1 ml iv, n = 8), a low-dose naloxone group (treated with naloxone 0.5 mg/kg iv, n = 8), or a high-dose naloxone group (HN-gro, treated with naloxone 1 mg/kg iv, n = 8) in a blinded fashion during resuscitation. At the end of 10 minutes of asphyxia, cardiopulmonary resuscitation was started, and each drug was administered at the same time. The rate of restoration of spontaneous circulation was seen in 1 of 8, 3 of 8, and 7 of 8 animals in the Sal-gro, LN-gro, and HN-gro, respectively. The rate of restoration of spontaneous circulation in HN-gro was significantly higher than that in Sal-gro (P < .05). Naloxone (1 mg/kg) alone can increase resuscitation rate following asphyxial cardiac arrest in rats.
Chen
Meng-Hua
MH
Institute of Cardiovascular Diseases, first affiliated hospital of Guangxi Medical University, Nanning 530027, PR China.
Liu
Tang-Wei
TW
Xie
Lu
L
Song
Feng-Qing
FQ
He
Tao
T
D000818:Animals; D001237:Asphyxia / Q000150:complications; D001794:Blood Pressure / Q000187:drug effects; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006323:Heart Arrest / Q000188:drug therapy* / Q000209:etiology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012119:Respiration / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome
D009292:Narcotic Antagonists; D009270:Naloxone