title: Direct access to heterocyclic scaffolds by new multicomponent Ugi-Smiles couplings.
abstract: New heterocyclic scaffolds can be easily prepared by the coupling of heteroaromatic phenols (pyridines, pyrimidines) with carbonyl compounds, amines, and isocyanides. This transformation related to the Ugi reaction probably involves a Smiles rearrangement. The scope of this methodology is further extended by the successful use of heterocyclic thiols to form highly functionalized thioamides.
authors.affiliation: Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Boulevard Victor, 75739 Paris Cedex 15, France. laurent.elkaim@ensta.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: El Kaim
authors.forename: Marie
authors.initials: M
authors.lastname: Gizolme
authors.forename: Laurence
authors.initials: L
authors.lastname: Grimaud
authors.forename: Julie
authors.initials: J
authors.lastname: Oble