Total synthesis of agelagalastatin.
The total synthesis of agelagalastatin, an antineoplastic glycosphingolipid, has been achieved. The synthesis involved an alpha-selective glycosylation of the ceramide moiety with the trisaccharide fluoride. The trisaccharide component was constructed employing the CB glycoside method which permitted a completely alpha-stereoselective galactofuranosylation.
Lee
Yong Joo
YJ
Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Lee
Bo-Young
BY
Jeon
Heung Bae
HB
Kim
Kwan Soo
KS
D047230:Agelas / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D020383:Neutral Glycosphingolipids / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D020383:Neutral Glycosphingolipids; C520907:agelagalastatin