title: Steroidal saponins from Solanum nigrum.
abstract: Six new steroidal saponins, solanigrosides C-H (2-7), and one known saponin, degalactotigonin (1), were isolated from the whole plant of Solanum nigrum. Their chemical structures were elucidated using spectroscopic analysis, chemical degradation, and derivatization. All seven compounds were tested for their cytotoxicity using four human tumor cell lines (HepG2, NCI-H460, MCF-7, SF-268). Only compound 1 was cytotoxic, with IC50 values of 0.25-4.49 microM.
authors.affiliation: Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
authors.forename: Xinlan
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiangjiu
authors.initials: X
authors.lastname: He
authors.forename: Guanghui
authors.initials: G
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Guangxiong
authors.initials: G
authors.lastname: Zhou
authors.forename: Wencai
authors.initials: W
authors.lastname: Ye
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032324:Solanum nigrum / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; D013256:Steroids; C513758:degalactotigonin