Genetic characterization of influenza A viruses (H5N1) isolated from 3rd wave of Thailand AI outbreaks.
Three major outbreaks of avian influenza (AI) occurred in Thailand. During the third episode in October 2005, we have isolated H5N1 viruses from one human case and three poultry cases. The whole genomes of AI viruses from human, chickens and quail from the outbreaks were characterized. Sequence analysis of eight gene segments revealed that the 2005 H5N1 viruses isolated in October 2005 were closely related to those recovered from chicken, tiger(s) and human(s) in January and July 2004. In addition, the genetic changes of the AI isolates at the HA cleavage site have been observed.
Amonsin
Alongkorn
A
Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Chutinimitkul
Salin
S
Pariyothorn
Nuananong
N
Songserm
Thaweesak
T
Damrongwantanapokin
Sudarat
S
Puranaveja
Suphasawatt
S
Jam-On
Rungroj
R
Sae-Heng
Namdee
N
Payungporn
Sunchai
S
Theamboonlers
Apiradee
A
Chaisingh
Arunee
A
Tantilertcharoen
Rachod
R
Suradhat
Sanipa
S
Thanawongnuwech
Roongroje
R
Poovorawan
Yong
Y
D000818:Animals; D004196:Disease Outbreaks / Q000662:veterinary; D016679:Genome, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics* / Q000302:isolation & purification*; D005585:Influenza in Birds / Q000453:epidemiology / Q000821:virology*; D007251:Influenza, Human / Q000821:virology*; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D011200:Poultry / Q000821:virology; D011784:Quail / Q000821:virology; D017385:Sequence Homology; D013785:Thailand / Q000453:epidemiology; D046010:Tigers / Q000821:virology
D019267:Hemagglutinin Glycoproteins, Influenza Virus; C109963:hemagglutinin, avian influenza A virus