title: Third-generation optical coherence tomography findings in punctate retinal toxoplasmosis.
abstract: OBJECTIVE
  To investigate optical coherence tomography (OCT) findings in patients with punctate retinal toxoplasmosis (PRT).
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  
  
  
  METHODS
  Tertiary ophthalmic referral center.
  
  
  METHODS
  Four patients with PRT consecutively evaluated between July 2004 and June 2005.
  
  
  METHODS
  Clinical examination and OCT.
  
  
  METHODS
  Morphologic features at baseline and changes within a 24-week follow-up interval.
  
  
  RESULTS
  Retinal layers were abnormally hyperreflective at the active lesion site and associated with some degree of retinal pigment epithelium-choriocapillaris/choroidal optical shadowing in all patients. The posterior hyaloid was thickened and focally detached (over the lesion). Additional findings include tractional maculopathy (n = 2) and diffuse macular edema (n = 1). During follow-up, focal choriocapillaris/choroidal relative hyperreflectivity was observed at the former lesion site, and posterior vitreous detachment progressed in all patients.
  
  
  CONCLUSIONS
  Our findings suggest that OCT may enable identification of subtle morphologic features previously underappreciated in patients with PRT, which may provide new insights about the disease pathophysiologic mechanisms.
authors.affiliation: Uveitis Section, Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Juliana L
authors.initials: JL
authors.lastname: Oréfice
authors.forename: Rogério A
authors.initials: RA
authors.lastname: Costa
authors.forename: Wesley
authors.initials: W
authors.lastname: Campos
authors.forename: Daniela
authors.initials: D
authors.lastname: Calucci
authors.forename: Ingrid U
authors.initials: IU
authors.lastname: Scott
authors.forename: Fernando
authors.initials: F
authors.lastname: Oréfice
mesh_terms: D000981:Antiprotozoal Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014126:Toxoplasmosis, Ocular / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology; D014822:Vitreous Body / Q000473:pathology*
chemical_list: D000981:Antiprotozoal Agents