title: Outcome after pancreatic necrosectomy: trends over 12 years at an Indian centre.
abstract: BACKGROUND
  Pancreatic necrosectomy for necrotizing pancreatitis is a formidable operation. There are limited data from the Indian subcontinent regarding outcome and recent trends in management.
  
  
  METHODS
  Patients undergoing pancreatic necrosectomy over a 12-year period were identified from a prospective database. Data regarding the hospital course, complications and outcome were extracted by case file review. Descriptive statistics were used to present the data. An attempt was made to identify trends in management and outcome over the study period.
  
  
  RESULTS
  One hundred and eighteen patients underwent necrosectomy. The median age was 39.5 years (interquartile range, 32-46). Median Acute Physiology And Chronic Health Evaluation II score at admission was 8 (interquartile range, 6-10). Thirty-nine patients (33%) had organ failure at admission. Patients underwent surgery a median of 23 days (interquartile range, 14-34) after onset of illness. There was high incidence of loco-regional complications (68/118, 58%) and organ failure (88/118, 75%) in the postoperative period. The mortality rate was 38%. There was an increase in the median onset to surgery interval (17 vs 25.5 days; P = 0.001), increased use of percutaneous interventions (20 vs 36%; P = 0.05) and decreased mortality (47 vs 29%; P = 0.052) in the later half of the study period.
  
  
  CONCLUSIONS
  Pancreatic necrosectomy continues to be associated with significant morbidity and mortality in India. A trend towards increased use of percutaneous interventions and delayed surgery is evident.
authors.affiliation: Department of General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Mettus
authors.initials: M
authors.lastname: Reddy
authors.forename: Ravul
authors.initials: R
authors.lastname: Jindal
authors.forename: Rajesh
authors.initials: R
authors.lastname: Gupta
authors.forename: Thakur D
authors.initials: TD
authors.lastname: Yadav
authors.forename: Jai Dev
authors.initials: JD
authors.lastname: Wig
mesh_terms: D000328:Adult; D016208:Databases, Factual; D004322:Drainage; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D019283:Pancreatitis, Acute Necrotizing / Q000601:surgery*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome