title: Phototherapeutic keratectomy with intraoperative mitomycin C to prevent recurrent anterior corneal pathology.
abstract: OBJECTIVE
  To determine the safety and efficacy of the use of intraoperative mitomycin C (MMC) during phototherapeutic keratectomy (PTK) for anterior corneal disease.
  
  
  METHODS
  Retrospective consecutive case series.
  
  
  METHODS
  Retrospective chart review of 13 eyes from 12 patients with various anterior corneal disorders who had phototherapeutic keratectomy with the use of intraoperative MMC from July 2001 to present. Data on healing time of epithelial defects, complications, and recurrence of disease were recorded.
  
  
  RESULTS
  Average time to heal of the epithelial defects was three days, no patient had corneal or scleral melting, and, as of the printing of this report, no patient has had recurrence of disease in the MMC-treated area.
  
  
  CONCLUSIONS
  MMC is safe for intraoperative use during PTK and does not appear to inhibit epithelial healing and may help prevent recurrent anterior corneal disease.
authors.affiliation: Cornea Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. bayres@willseye.org
authors.forename: Brandon D
authors.initials: BD
authors.lastname: Ayres
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Hammersmith
authors.forename: Peter R
authors.initials: PR
authors.lastname: Laibson
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Rapuano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002648:Child; D003131:Combined Modality Therapy; D003316:Corneal Diseases / Q000517:prevention & control*; D006801:Humans; D007430:Intraoperative Care; D054018:Lasers, Excimer; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D018903:Photorefractive Keratectomy / Q000379:methods*; D012189:Retrospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin