Primary systemic therapy for operable breast cancer: a review of clinical trials and perspectives.
Primary systemic therapy represents the standard of care for locally advanced breast cancer and has becoming an attractive alternative in earlier stages. A part from the proven advantage of increasing the rate of breast conservative surgery, the up front use of systemic therapy can allow for an in vivo test of treatment sensitivity, and response to primary treatment discriminates patients at different prognosis. This review will summarize the more relevant data on the preoperative treatment with chemotherapy, hormonal therapy and targeted agents.
Guarneri
Valentina
V
Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy. guarneri.valentina@unimore.it
Frassoldati
Antonio
A
Giovannelli
Simona
S
Borghi
Francesca
F
Conte
PierFranco
P
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D016032:Randomized Controlled Trials as Topic
D000970:Antineoplastic Agents