A rare cause of polyhydramnios: Neu-Laxova syndrome.
Neu-Laxova syndrome is a rare group of congenital malformations including intrauterine growth retardation (IUGR), microcephaly, central nervous system alterations, facial abnormalities, ichthyosis, limb abnormalities, generalized edema, polyhydramnios, and perinatal death. Thirty cases have been identified since the publication of the first two cases and only five of them had a prenatal diagnosis. The earliest diagnosis in a published case was at week 32 of gestation. This study illustrates that the detection of the syndrome during the second trimester of gestation is possible, with emphasis on the detection of the early appearance of polyhydramnios and the association of the syndrome with the Arabic ethnic group.
Martín
Alicia
A
Gynaecology and Obstetrics Department, University Hospital Materno Infantil of the Canaries, Las Palmas de Gran Canaria, Canary Islands, Spain.
Eguiluz
Idoya
I
Barber
Miguel A
MA
Medina
Norberto
N
Plasencia
Walter
W
García-Alix
Alfredo
A
García-Hernández
José A
JA
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging*; D025063:Chromosome Disorders; D019465:Craniofacial Abnormalities / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D005313:Fetal Death; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging*; D006801:Humans; D017880:Limb Deformities, Congenital / Q000000981:diagnostic imaging*; D009421:Nervous System Malformations / Q000000981:diagnostic imaging*; D006831:Polyhydramnios / Q000000981:diagnostic imaging / Q000209:etiology*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013577:Syndrome; D016216:Ultrasonography, Prenatal