Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity.
Central nervous system (CNS) injuries are particularly traumatic, owing to the limited capabilities of the mammalian CNS for repair. Nevertheless, functional recovery is observed in patients and experimental animals, but the degree of recovery is variable. We review the crucial characteristics of mammalian spinal cord function, tract development, injury and the current experimental therapeutic approaches for repair. Regenerative or compensatory growth of neurites and the formation of new, functional circuits require spontaneous and experimental reactivation of developmental mechanisms, suppression of the growth-inhibitory properties of the adult CNS tissue and specific targeted activation of new connections by rehabilitative training.
Maier
Irin C
IC
Brain Research Institute, University and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. imaier@hifo.unizh.ch
Schwab
Martin E
ME
D000818:Animals; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D013116:Spinal Cord / Q000254:growth & development*; D013119:Spinal Cord Injuries / Q000378:metabolism*