title: A new application of pre-normalized principal component analysis for improvement of image quality and clinical diagnosis in human brain PET studies--clinical brain studies using [11C]-GR205171, [11C]-L-deuterium-deprenyl, [11C]-5-Hydroxy-L-Tryptophan, [11C]-L-DOPA and Pittsburgh Compound-B.
abstract: Principal component analysis (PCA) is one of the most applied multivariate image analysis tool on dynamic Positron Emission Tomography (PET). Independent of used reconstruction methodologies, PET images contain correlation in-between pixels, correlations in-between frame and errors caused by the reconstruction algorithm including different corrections, which can affect the performance of the PCA. In this study, we have investigated a new approach of application of PCA on pre-normalized, dynamic human PET images. A range of different tracers have been used for this purpose to explore the performance of the new method as a way to improve detection and visualization of significant changes in tracer kinetics and to enhance the discrimination between pathological and healthy regions in the brain. We compare the new results with the results obtained using other methods. Images generated using the new approach contain more detailed anatomical information with higher quality, precision and visualization, compared with images generated using other methods.
authors.affiliation: Uppsala University, Centre for Image Analysis, Lägerhyddsv. 3, SE-752 37 Uppsala, Sweden.
authors.forename: Pasha
authors.initials: P
authors.lastname: Razifar
authors.forename: Jan
authors.initials: J
authors.lastname: Axelsson
authors.forename: Harald
authors.initials: H
authors.lastname: Schneider
authors.forename: Bengt
authors.initials: B
authors.lastname: Långström
authors.forename: Ewert
authors.initials: E
authors.lastname: Bengtsson
authors.forename: Mats
authors.initials: M
authors.lastname: Bergström
mesh_terms: D000932:Antiemetics / Q000493:pharmacokinetics; D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D003903:Deuterium / Q000493:pharmacokinetics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000592:standards*; D007980:Levodopa / Q000493:pharmacokinetics; D010880:Piperidines / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D012642:Selegiline / Q000493:pharmacokinetics; D013777:Tetrazoles / Q000493:pharmacokinetics
chemical_list: D000932:Antiemetics; D002250:Carbon Radioisotopes; D010880:Piperidines; D013777:Tetrazoles; D012642:Selegiline; D007980:Levodopa; D003903:Deuterium; C103207:vofopitant