[Effects of telomerase on cell cycle regulation and tumorigenesis].
Since the original discovery of telomerase, a clear association with cancer has been demonstrated. Cell-cycle dysregulation is a hallmark of tumor cells. The ability of normal cells to undergo cell-cycle arrest after damage to DNA is crucial for the maintenance of genomic integrity. The biochemical pathways that stop the cell cycle in response to cellular stressors are called checkpoints. Defective checkpoint function results in genetic modifications that contribute to tumorigenesis. This review summarizes the current knowledge about the relation of telomerase activity, dysregulation of Cell-cycle and tumorigenesis.
Yan
Li-Ping
LP
Institute for Environment Hygiene and Health Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing100021, China.
Tao
Mao-Xuan
MX
D002453:Cell Cycle / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D019098:Telomerase / Q000378:metabolism / Q000502:physiology*
D019098:Telomerase