title: Ovulation induction by antiestrogens in an Indian tropical vespertillionid bat, Scotophilus heathi.
abstract: The ovulation induction property of ICI 182,780 a pure antiestrogen and enclomiphene citrate (ENC) was carried out in Scotophilus heathi, an Indian tropical vespertillionid bat, during December to February i.e., preovulatory period. This bat ovulates two ova naturally and shows ovulatory asynchrony. The study showed that 100 ìg of ENC followed by 10 IU hCG resulted in significantly lower number of ovulation. Whereas, the pure antiestrogen ICI 182,780 at a dose of 100 ìg followed by 10 IU hCG resulted in ovulation induction (4.2 +/- 0.4), which is significantly different in comparison to other groups. This is possibly the first report of ovulation induction using this pure antiestrogen i.e., ICI 182,780 in any bat as well as in any animal model that exhibits temporary anovulation similar to polycystic ovary disease (PCOD). This antiestrogen may be useful to induce ovulation in PCOD patients.
authors.affiliation: Embryo Physiology Laboratory, Center of Advanced Study, Department of Zoology, Banaras Hindu University, Varanasi-221005, India. pakrasi@bhu.ac.in
authors.forename: Pranab Lal
authors.initials: PL
authors.lastname: Pakrasi
authors.forename: Anjana
authors.initials: A
authors.lastname: Tiwari
mesh_terms: D000818:Animals; D000858:Anovulation / Q000188:drug therapy / Q000473:pathology; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D002685:Chiroptera / Q000378:metabolism*; D002996:Clomiphene / Q000494:pharmacology*; D064695:Enclomiphene; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology; D000077267:Fulvestrant; D006801:Humans; D007194:India; D010060:Ovulation / Q000187:drug effects*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D005300:Fertility Agents, Female; D002996:Clomiphene; D000077267:Fulvestrant; D004958:Estradiol; D064695:Enclomiphene