Huge proteins in the human proteome and their participation in hereditary diseases.
Protein lengths vary considerably from a few to thousands of amino acids and length variations are documented to have multiple effects. A computational approach to investigate the functional impact of protein length variation in genetic disorders is presented. The genes for huge proteins are found to have more introns. Our analysis also shows greater involvement of huge proteins in hereditary diseases.
Sakharkar
Meena Kishore
MK
Nanyang Centre for Supercomputing and Visualization, MAE, Nanyang Technological University, Singapore. mmeena@ntu.edu.sg
Kangueane
Pandjassarame
P
Sakharkar
Kishore Ramaji
KR
Zhong
Zhaowei
Z
D005091:Exons; D030342:Genetic Diseases, Inborn / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007438:Introns; D008954:Models, Biological; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020543:Proteome
D011506:Proteins; D020543:Proteome