Spatial relationship of source localizations in patients with focal epilepsy: Comparison of MEG and EEG with a three spherical shells and a boundary element volume conductor model.
Epilepsy surgery is an option for patients with pharmacoresistant focal epilepsies, but it requires a precise focus localization procedure. Magnetoencephalography (MEG) and electroencephalography (EEG) can be used for analysis of interictal activity. The aim of this prospective study was to compare clusters of source localization results with MEG and EEG using a three spherical shells (3SS) and a boundary element method (BEM) volume conductor model. The study was closed when 100 patients met the inclusion criteria. Simultaneous MEG and EEG were recorded during presurgical evaluation. Epileptiform signals were analyzed using an equivalent current dipole model. Centroids of source localizations from MEG, EEG, 3SS, and BEM in their respective combinations were compared. In a 3SS model, MEG source localizations were 5.6 mm inferior to those obtained by EEG, while in a BEM model MEG source localizations were 6.3 mm anterior and 4.8 mm superior. The mean scattering of source localizations between both volume conductor models was 19.5 mm for EEG and 9.6 mm for MEG. For MEG no systematic difference between BEM and 3SS source localizations was found. For EEG, source localizations with BEM were 5.9 mm posterior and 11.7 mm inferior to those determined using 3SS. No differences were found between the 46 temporal and the 54 extratemporal lobe epilepsy patients. The observed systematic differences of source localizations of epileptic spikes due to the applied source signal modality and volume conductor model should be considered in presurgical evaluation when only one source signal and volume conductor model is available.
Scheler
Gabriela
G
Epilepsy and Neurocenter, Department of Neurology, University of Erlangen-Nürnberg, Erlangen, Germany. gabriela.scheler@neuro.imed.uni-erlangen.de
Fischer
Michael J M
MJ
Genow
Alexandra
A
Hummel
Cornelia
C
Rampp
Stefan
S
Paulini
Andrea
A
Hopfengärtner
Rüdiger
R
Kaltenhäuser
Martin
M
Stefan
Hermann
H
D000328:Adult; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D004553:Electric Conductivity; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D015225:Magnetoencephalography; D008875:Middle Aged; D008959:Models, Neurological; D011300:Preoperative Care