[Effects of moxibustion preconditioning on SOD and MDA in rats with global brain ischemia].
OBJECTIVE
To reveal the mechanism of moxibustion preconditioning in preventive brain-protecting action.


METHODS
The rat model of global brain ischemia was made with 4-artery ligation method. 78 Wistar rats were randomly divided into 5 groups: normal control group, sham-operation group, brain ischemia group, brain ischemia preconditioning group and moxibustion preconditioning group. The brain was taken 24 h, 48 h and 72 h after operation in the all groups, respectively, for determination of SOD activities by xanthine oxidase method and MDA content by thibabituric acid method.


RESULTS
The SOD activity significantly increased, especially 24 h after the moxibustion preconditioning, and the MDA content decreased significantly with a very significant difference as compared with the ischemia group(P<0.01).


CONCLUSIONS
Moxibustion preconditioning exerts the protective action on the brain tissue of ischemia and anoxia through increasing the endogenous anti-oxidase activity.
Hua
Jin-shuang
JS
Henan College of TCM, Zhengzhou 450008, China. hjsh2002@126.com
Li
Li-ping
LP
Zhu
Xian-min
XM
D000818:Animals; D001921:Brain; D002545:Brain Ischemia; D007511:Ischemia; D009071:Moxibustion; D051381:Rats; D017208:Rats, Wistar