title: [Prevention of cleft lip and palate. Reducing risk of recurrence--a 25-year clinical experience].
abstract: From 1980 to 2005, 71 female patients having non-syndromic cleft lip and palate (CLP) or cleft palate (CP) themselves or in their family and desiring to have children underwent 88 times a cleft prevention protocol with high doses of Vitamin B Complex and Actovegin twice a week. The data about the outcome of the pregnancy were prospectively collected. Empiric data of the recurrence risks from the literature depending on the cleft type were used as comparative group. In 80 cases, a healthy child was born. In two cases microsymptoms of unilateral lip notches were observed. The observed risks with prophylaxis were 2.9% (only microsymptoms!) and 0% comparing with 4.9% and 2.4% respectively in the controls. The relative risk as reference value between expected and observed risk was 0.6 (microsymptoms) for CLP and 0 for CP.
authors.affiliation: Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Martin-Luther-Universität Halle-Wittenberg, Herweghstrasse 88, 06114, Halle, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schubert
authors.forename: Birgit
authors.initials: B
authors.lastname: Krost
mesh_terms: D000293:Adolescent; D000328:Adult; D002971:Cleft Lip / Q000235:genetics / Q000517:prevention & control*; D002972:Cleft Palate / Q000235:genetics / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005865:Gestational Age; D006418:Heme / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care; D011446:Prospective Studies; D012306:Risk; D055502:Secondary Prevention; D014803:Vitamin B Complex / Q000008:administration & dosage*
chemical_list: D014803:Vitamin B Complex; D006418:Heme; C015646:Actovegin