title: Haplotypes in the promoter region of the ADIPOQ gene are associated with increased diabetes risk in a German Caucasian population.
abstract: Adiponectin, which is encoded by the ADIPOQ gene, has been shown to modulate insulin sensitivity and glucose homeostasis. Plasma adiponectin levels are decreased in type 2 diabetes and obesity. Genetic variations within the ADIPOQ gene are associated with decreased adiponectin hormone levels. To analyze specific single-nucleotide polymorphisms (SNPs) and their association with T2D, 365 German subjects with T2D and 323 control subjects were screened. Three common SNPs - +45T>G in exon 2, and 2 promoter variants SNPs -11391G>A and -11377C>G - were analyzed. We found that the variant allele of SNP -11391G>A was significantly more frequent in the diabetic patient group than in the control group (p=0.003). Carrying the haplotype of SNP -11391A and SNP -11377C was associated with a 1.50-fold (p=0.03) increase in diabetes risk. The combination of the A-C haplotype and the G-C haplotype was associated with significantly elevated diabetes risk (OR=2.82 (95% CI: 1.35-5.91), p=0.006) after correction for BMI and age. Our observations suggest that diploid combinations of haplotype in the adiponectin gene promoter region contribute to the genetic risk of T2D in individuals from a German Caucasian population.
authors.affiliation: III Medical Clinic Department of Endocrinopathies and Metabolic Diseases, Dresden, Germany. pschwarz@rcs.urz.tu-dresden.de
authors.forename: P E H
authors.initials: PE
authors.lastname: Schwarz
authors.forename: S
authors.initials: S
authors.lastname: Govindarajalu
authors.forename: W
authors.initials: W
authors.lastname: Towers
authors.forename: U
authors.initials: U
authors.lastname: Schwanebeck
authors.forename: S
authors.initials: S
authors.lastname: Fischer
authors.forename: F
authors.initials: F
authors.lastname: Vasseur
authors.forename: S R
authors.initials: SR
authors.lastname: Bornstein
authors.forename: J
authors.initials: J
authors.lastname: Schulze
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005858:Germany; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D044465:White People
chemical_list: D052242:Adiponectin