Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells.
Petrache
Irina
I
Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA. ipetrach@iupui.edu
Natarajan
Viswanathan
V
Zhen
Lijie
L
Medler
Terry R
TR
Richter
Amy
A
Berdyshev
Evgeni V
EV
Tuder
Rubin M
RM
D000818:Animals; D017209:Apoptosis; D002518:Ceramides / Q000096:biosynthesis*; D006801:Humans; D051379:Mice; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000473:pathology*; D011656:Pulmonary Emphysema / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D012907:Smoking / Q000009:adverse effects / Q000378:metabolism; D013107:Sphingolipids / Q000378:metabolism*; D015854:Up-Regulation
D002518:Ceramides; D013107:Sphingolipids