title: Fluorinated natural products with clinical significance.
abstract: The modification of natural products in an effort to alter their biochemical capacity is a common technique utilized by synthetic and medicinal chemists. Fluorine substitution imparts unique and advantageous physiochemical properties that can be shrewdly employed to constructively alter pharmacological agents. The adornment of natural products with fluorine has proven beneficial in several examples. This overview discusses several of the most relevant fluorinated natural products under current examination.
authors.affiliation: Chemical Biology Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. craigt@niddk.nih.gov
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Thomas
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D005459:Fluorides / Q000737:chemistry* / Q000494:pharmacology; D005461:Fluorine / Q000737:chemistry* / Q000494:pharmacology; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D001688:Biological Products; D006845:Hydrocarbons, Fluorinated; D005461:Fluorine; D005459:Fluorides