title: Marked abnormal quadruple screen in a patient with severe preeclampsia at 20 weeks with a triploid fetus.
abstract: Severe preeclampsia rarely occurs prior to 20 weeks of gestation except in pregnancies with triploidy. The patient reported herein is a 29-year-old primigravida who developed severe preeclampsia at 20 weeks of gestation. Evaluation of the pregnancy demonstrated a markedly abnormal quadruple screen. Amniocentesis demonstrated a fetus with triploidy, despite a normal appearance.
authors.affiliation: Department of Obstetrics and Gynecology, Creighton University Medical Center, Omaha, NE 68131, USA. mbarsoom@creighton.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Barsoom
authors.forename: Amy
authors.initials: A
authors.lastname: McEntaffer
authors.forename: Alfred
authors.initials: A
authors.lastname: Fleming
authors.forename: Henry C
authors.initials: HC
authors.lastname: Nipper
mesh_terms: D000328:Adult; D000649:Amniocentesis; D006063:Chorionic Gonadotropin / Q000097:blood; D002869:Chromosome Aberrations / Q000196:embryology*; D005260:Female; D005313:Fetal Death; D005315:Fetal Diseases / Q000175:diagnosis* / Q000235:genetics; D005865:Gestational Age; D006801:Humans; D007265:Inhibins / Q000097:blood; D011123:Polyploidy; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; C422362:inhibin A; D007265:Inhibins