title: Long-range histone acetylation: biological significance, structural implications, and mechanisms.
abstract: Genomic characterization of various euchromatic regions in higher eukaryotes has revealed that domain-wide hyperacetylation (over several kb) occurs at a range of loci, including individual genes, gene family clusters, compound clusters, and more general clusters of unrelated genes. Patterns of long-range histone hyperacetylation are strictly conserved within each unique cellular system studied and they reflect biological variability in gene regulation. Domain-wide histone acetylation consists generally of nonuniform peaks of enriched hyperacetylation of specific core histones, histone isoforms, and (or) histone variants against a backdrop of nonspecific acetylation across the domain in question. Here we review the characteristics of long-range histone acetylation in some higher eukaryotes and draw special attention to recent literature on the multiple effects that histone hyperacetylation has on chromatin's structural integrity and how they affect transcription. These include the thermal, ionic, cumulative, and isoform-specific (H4 K16) consequences of acetylation that result in a more dynamic core complex and chromatin fiber.
authors.affiliation: Department of Biochemistry and Microbiology, University of Victoria, Petch building, 220, Victoria, BC V8W 3P6, Canada.
authors.forename: Alison
authors.initials: A
authors.lastname: Calestagne-Morelli
authors.forename: Juan
authors.initials: J
authors.lastname: Ausió
mesh_terms: D000107:Acetylation; D000818:Animals; D002645:Chickens; D005914:Globins / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D005914:Globins