Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets.
Resveratrol (3,4',5-trihydroxystilbene) has a very broad range of biological properties, including antiplatelet and antioxidative activity. We investigated in vitro the effect of resveratrol on carbonylation of proteins (indicators of oxidative stress) in blood platelets treated with peroxynitrite (ONOO(-)), a strong biological oxidant and inflammatory mediator. We observed that carbonylation of proteins induced by ONOO(-) (0.1 mmol/l), in the presence of resveratrol (0.25-0.1 mmol/l) is reduced. Resveratrol may scavenge ONOO(-), and may be useful in the prevention of ONOO(-)-related diseases, such as inflammatory and cardiovascular diseases.
Olas
B
B
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland. olasb@biol.uni.lodz.pl
Nowak
P
P
Ponczek
M
M
Wachowicz
B
B
D000975:Antioxidants / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002244:Carbon / Q000737:chemistry; D003124:Colorimetry; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007249:Inflammation; D015227:Lipid Peroxidation; D010100:Oxygen / Q000737:chemistry; D030421:Peroxynitrous Acid / Q000737:chemistry*; D019800:Phenol / Q000737:chemistry; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D000975:Antioxidants; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D030421:Peroxynitrous Acid; D019800:Phenol; D002244:Carbon; D000077185:Resveratrol; D010100:Oxygen