Pertussis vaccine effectiveness in reducing clinical disease, transmissibility and proportion of cases with a positive culture after household exposure in Brazil.
In household outbreaks of pertussis, children <5 years of age who received at least 3 doses of vaccine had 12% less clinical disease; vaccinated cases were 63% less culture-confirmed and transmitted infection to 62% fewer contacts. Three doses of pertussis vaccine are likely to decrease circulation of Bordetella pertussis by reducing the proportion of bacteriologically positive cases and transmissibility.
Baptista
Paulo N
PN
Pediatric Infectious Diseases Service, Federal University of Pernambuco, Pernambuco, Brazil. psjn@terra.com.br
Magalhães
Vera
V
Rodrigues
Laura C
LC
Rocha
MariaAngela W
MW
Pimentel
Analíria M
AM
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010567:Pertussis Vaccine / Q000627:therapeutic use*; D014917:Whooping Cough / Q000517:prevention & control* / Q000635:transmission
D010567:Pertussis Vaccine