Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin.
This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies.
Carpizo
Rosario
R
Unit of Sleep Disorders, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria, Herrera Oria s/n, 39011 Santander, Spain.
Martínez
Angeles
A
Mediavilla
Dolores
D
González
Mónica
M
Abad
Araceli
A
Sánchez-Barceló
Emilio J
EJ
D000070:Acebutolol / Q000008:administration & dosage*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D002675:Child, Preschool; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D019454:Chronotherapy; D006801:Humans; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D020178:Sleep Disorders, Circadian Rhythm / Q000188:drug therapy* / Q000235:genetics; D013577:Syndrome
D000319:Adrenergic beta-Antagonists; D000975:Antioxidants; D000070:Acebutolol; D008550:Melatonin