Pediatric posttraumatic seizures: epidemiology, putative mechanisms of epileptogenesis and promising investigational progress.
Posttraumatic seizures and epilepsy are common in children experiencing traumatic brain injury and portend worse functional outcome. Unfortunately, the pathogenesis of pediatric posttraumatic seizures and epilepsy remains poorly understood, and no efficacious preventive therapy for post-traumatic epilepsy has been identified. This article reviews the epidemiology of pediatric posttraumatic seizures, discusses prominent putative mechanisms of posttraumatic epileptogenesis and highlights recent promising progress in experimental investigations of posttraumatic seizures and epilepsy.
Statler
Kimberly D
KD
Division of Critical Care, Department of Pediatrics, The University of Utah School of Medicine, Salt Lake City, Utah 84158-0289, USA. kim.statler@hsc.utah.edu
D000375:Aging / Q000502:physiology; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism / Q000503:physiopathology*; D001930:Brain Injuries / Q000453:epidemiology* / Q000503:physiopathology*; D002648:Child; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology*; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D009415:Nerve Net / Q000378:metabolism / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology