title: A multi-scale computational method applied to the quantitative evaluation of the left ventricular function.
abstract: A multi-scale computational method, which combines a lumped parameter model of the cardiovascular system (CVS) with a three-dimensional (3D) left ventricle (LV) hemodynamic solver, is developed for quantitatively evaluating the LV function. The parameter model allows reasonable predictions of the cardiac variables in a closed-loop manner under both normal and various pathological conditions. On the basis of the parameter-model-predicted results, 3D hemodynamic computations further provide quantitative insights into the detailed intraventricular flow patterns. Based on a series of computations, it is demonstrated that the pathological change in the shape and size of the LV has a significant effect on the LV pumping performance.
authors.affiliation: Graduate School of Science and Technology, Chiba University, Chiba, Japan.
authors.forename: Fuyou
authors.initials: F
authors.lastname: Liang
authors.forename: Hisashi
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D016275:Atrial Function / Q000502:physiology; D001775:Blood Circulation / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D002303:Cardiac Output, Low / Q000503:physiopathology; D002306:Cardiac Volume / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D003198:Computer Simulation; D005544:Forecasting; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology; D017725:Ventricular Pressure / Q000502:physiology