title: IL-1 gene polymorphism and periodontal status of HIV Brazilians on highly active antiretroviral therapy.
abstract: A genotype in the IL-1 gene cluster is associated with an increased risk of periodontitis. We investigated whether polymorphisms in the IL-1A +4845 and IL-1B +3954 loci affect the periodontal status of HIV-infected Brazilians on HAART. HIV-positive and HIV-negative subjects with periodontitis were genotyped for IL-1 by polymerase chain reaction and restriction enzyme digestion. Only 11.4% of patients were genotype positive. No associations between genotype positivity and HIV infection or periodontal status were found in this population.
authors.affiliation: Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Lucio de S
authors.initials: LS
authors.lastname: Gonçalves
authors.forename: Sônia Maria S
authors.initials: SM
authors.lastname: Ferreira
authors.forename: Celso O
authors.initials: CO
authors.lastname: Souza
authors.forename: Ana Paula V
authors.initials: AP
authors.lastname: Colombo
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001938:Brazil; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D010518:Periodontitis / Q000139:chemically induced*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D007375:Interleukin-1