Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone.
The endogenous ligand for the growth-hormone (GH) secretagogue receptor was purified from stomach and named ghrelin. It has potent GH-releasing activity and stimulates appetite by acting on the hypothalamic arcuate nucleus, a region known to control food intake. Ghrelin thus plays important roles in maintaining GH release and energy homeostasis in vertebrates. Ghrelin, moreover, stimulates gastric motility and acid secretion, shows positive cardiovascular effects, and has direct actions on bone formation. The diverse functions of ghrelin raise the possibility of its clinical application for GH deficiency, eating disorders, gastrointestinal disease, cardiovascular disease, osteoporosis and aging.
Kojima
Masayasu
M
Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan. mkojima@lsi.kurume-u.ac.jp
Kangawa
Kenji
K
D000595:Amino Acid Sequence; D001066:Appetite / Q000187:drug effects / Q000502:physiology*; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects / Q000502:physiology; D002149:Energy Intake; D054439:Ghrelin; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008969:Molecular Sequence Data; D036361:Peptide Hormones / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000235:genetics
D054439:Ghrelin; D036361:Peptide Hormones; D012333:RNA, Messenger; D013006:Growth Hormone