Dominantly transmitted focal dystonia in families of patients with musician's cramp.
Musician's dystonia is generally considered a sporadic disorder. We present three families with the index patient affected by musician's dystonia, but other forms of upper limb focal task-specific dystonia (FTSD), mainly writer's cramp, in seven relatives. Our results suggest a genetic contribution to FTSD with phenotypic variability, including musician's dystonia.
Schmidt
A
A
Institute of Music Physiology and Musicians' Medicine, Hanover University of Music and Drama, Hanover, Germany.
Jabusch
H-C
HC
Altenmüller
E
E
Hagenah
J
J
Brüggemann
N
N
Hedrich
K
K
Saunders-Pullman
R
R
Bressman
S B
SB
Kramer
P L
PL
Klein
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004421:Dystonia / Q000453:epidemiology* / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D005190:Family; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000453:epidemiology* / Q000235:genetics*; D009146:Music; D009784:Occupational Diseases / Q000453:epidemiology* / Q000235:genetics*; D010375:Pedigree; D010865:Pilot Projects; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors