title: Structural variants deconstruct the genome.
abstract: Common genomic structural variants predispose to deleterious de novo genomic rearrangements. Understanding how they do so will require population studies across the continuum of genomic variation and ethical discussion of the nature and uses of human variation.
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics; D017353:Gene Deletion; D020440:Gene Duplication; D015870:Gene Expression; D015321:Gene Rearrangement; D030342:Genetic Diseases, Inborn / Q000209:etiology / Q000235:genetics; D014644:Genetic Variation / Q000941:ethics*; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide