[Microparticles during sepsis and trauma. A link between inflammation and thrombotic processes].
Sepsis and trauma lead to a sustained activation of monocytes and endothelium. In the vascular compartment, stimulated cells release microparticles. Circulating MP provide an additional procoagulant phospholipid surface enabling the assembly of the clotting enzymes complexes and thrombin generation. Their procoagulant properties rely on the exposition of phosphatidylserine, made accessible after cell stimulation and on the possible presence of tissue factor, the main cellular initiator of blood coagulation. Microparticles constitute the main reservoir of blood-borne tissue factor activity. At sites of endothelium injury, enhanced release or recruitment of procoagulant MP through P-selectin-PSGL-1 pathway could concentrate TF activity above a threshold allowing blood coagulation to be triggered. Converging evidences from experimental or clinical data highlight a role for MP harboring tissue factor in the initiation of disseminated intravascular coagulopathy. In these settings, the pharmacological modulation of MP levels or biological functions through activated protein C or factor VIIa allows challenging issues.
Morel
N
N
Service d'urgences et de réanimation chirurgicale, hôpital Pellegrin, Bordeaux, France.
Morel
O
O
Delabranche
X
X
Jesel
L
L
Sztark
F
F
Dabadie
P
P
Freyssinet
J-M
JM
Toti
F
F
D017209:Apoptosis; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology*; D008955:Models, Cardiovascular; D009000:Monocytes / Q000648:ultrastructure*; D018805:Sepsis / Q000097:blood*; D013927:Thrombosis / Q000097:blood / Q000503:physiopathology*; D014947:Wounds and Injuries / Q000097:blood