title: Coronary artery bypass grafting is superior to percutaneous coronary intervention in prevention of perioperative myocardial infarctions during subsequent vascular surgery.
abstract: BACKGROUND
  Among patients in need of coronary revascularization before an elective vascular operation, the value of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in preventing perioperative myocardial infarctions is uncertain. We hypothesized that more complete revascularization would improve outcomes after vascular surgery.
  
  
  METHODS
  In this Veterans Affairs Cooperative trial involving 18 medical centers, 222 patients underwent elective vascular surgery after coronary revascularization. The mode of coronary revascularization was selected at each site by the local investigators (CABG in 91 patients and PCI in 131 patients). The vascular surgical indications were similar in both groups.
  
  
  RESULTS
  There were 2 deaths in the CABG group (2.2%) and 5 deaths in the PCI group (3.8%; p = 0.497) after the vascular procedure. There were fewer perioperative myocardial infarctions after the vascular operation in CABG patients (6.6%) than in PCI patients (16.8%; p = 0.024), despite more diseased vessels in the CABG group (3.0 +/- 1.3 versus 2.2 +/- 1.4, respectively; p < 0.001). The completeness of revascularization (defined as the number of coronary artery vessels revascularized relative to the total number of vessels with a stenosis > or = 70%) in patients in the CABG and PCI groups was 117% +/- 63% and 81% +/- 57%, respectively (p < 0.001). Hospital length of stay in CABG versus PCI patients was 6 (4, 8) and 7 (4, 10) days, respectively (p = 0.078).
  
  
  CONCLUSIONS
  Among patients receiving multivessel coronary artery revascularization as prophylaxis for elective vascular surgery, patients having a CABG had fewer myocardial infarctions and tended to spend less time in the hospital after the vascular operation than patients having a PCI. More complete revascularization accounted for the intergroup differences.
authors.affiliation: Department of Surgery, VA Medical Center and University of Minnesota, Minneapolis, Minnesota 55417, USA. wardx020@umn.edu
authors.forename: Herbert B
authors.initials: HB
authors.lastname: Ward
authors.forename: Rosemary F
authors.initials: RF
authors.lastname: Kelly
authors.forename: Lizy
authors.initials: L
authors.lastname: Thottapurathu
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Moritz
authors.forename: Greg C
authors.initials: GC
authors.lastname: Larsen
authors.forename: Gordon
authors.initials: G
authors.lastname: Pierpont
authors.forename: Steve
authors.initials: S
authors.lastname: Santilli
authors.forename: Steven
authors.initials: S
authors.lastname: Goldman
authors.forename: William C
authors.initials: WC
authors.lastname: Krupski
authors.forename: Fred
authors.initials: F
authors.lastname: Littooy
authors.forename: Domenic J
authors.initials: DJ
authors.lastname: Reda
authors.forename: Edward O
authors.initials: EO
authors.lastname: McFalls
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000706:statistics & numerical data*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D007866:Leg / Q000098:blood supply / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D013997:Time Factors