title: Dramatic etanercept-induced remission of relapsing febrile sciatic neuralgia related to p46l mutation of the tnfrsf1a gene.
abstract: An adult patient experienced attacks of severe low back pain and sciatic neuralgia for several years, sometimes associated with myalgias, skin lesions, and high fever. Specific inflammatory laboratory tests were the major abnormalities. P46L mutation in the gene on chromosome 12p13 that encodes tumor necrosis factor receptor superfamily 1A (TNFRSF1A) was found. Management with anti-TNF agent was effective with a complete remission of bouts of pain and fever.
authors.affiliation: Service de Médecine Interne, du Professeur Pierre Jean Weiller, CHU de La Timone, 264 rue Saint Pierre, 13385 Marseille Cedex 05, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Serratrice
authors.forename: Christine
authors.initials: C
authors.lastname: de Roux-Serratrice
authors.forename: Patrick
authors.initials: P
authors.lastname: Disdier
authors.forename: Catherine
authors.initials: C
authors.lastname: Dodé
authors.forename: Pierre-Jean
authors.initials: PJ
authors.lastname: Weiller
mesh_terms: D000068800:Etanercept; D005334:Fever / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000187:drug effects / Q000235:genetics*; D012585:Sciatica / Q000150:complications / Q000188:drug therapy / Q000235:genetics; D013577:Syndrome; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept