Shear stress in cells generated by ultrasound.
An experimental study using a mason horn of 21.4 kHz indicated that the threshold shear stress for cell sonoporation was 12+/-4 Pa for ultrasound exposure time up to 7 min. Numerical calculations have shown that shear stress associated with microstreaming surrounding encapsulated bubbles may be large enough to generate sonoporation at 0.1 MPa of 1 or 2 MHz ultrasound.
Wu
Junru
J
Department of Physics, University of Vermont, Burlington, VT 05405, USA. Jun-ru@uvm.edu
D002462:Cell Membrane / Q000502:physiology* / Q000528:radiation effects*; D002463:Cell Membrane Permeability / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects; D003198:Computer Simulation; D004548:Elasticity; D006801:Humans; D019169:Jurkat Cells; D040542:Mechanotransduction, Cellular / Q000502:physiology* / Q000528:radiation effects*; D008954:Models, Biological; D015612:Phonophoresis / Q000379:methods*; D011829:Radiation Dosage; D033081:Shear Strength; D013314:Stress, Mechanical