title: The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer.
abstract: CONCLUSIONS
  SPECT-CT may improve the localization of sentinel nodes (SNs) in patients with oral squamous cell carcinoma (OSCC). Compared with planar lymphoscintigraphy SPECT-CT detected more SNs and provided additional anatomical and spatial information about their localization. New generation SPECT with higher resolution CT scanners are expected to provide more accurate information about the localization of SNs.
  
  
  OBJECTIVE
  To assess the role of combined SPECT-CT in SN identification in the clinically negative neck of patients with OSCC.
  
  
  METHODS
  Lymphoscintigraphy comprising planar and SPECT-CT acquisition was performed in 34 consecutive patients with OSCC stage I and II (T1-2N0M0) prior to sentinel node biopsy (SNB) and selective neck dissection. The number of SNs and anatomical location was recorded according to lymphoscintigraphy and operative findings.
  
  
  RESULTS
  SNB was conducted in 33 patients. SNs were identified in 94% (32/34) of the patients using SPECT-CT. In 91% (29/32) of the patients SNs were harvested from all of the levels involved on SPECT-CT. SPECT-CT imaging demonstrated extra SNs compared with planar lymphoscintigraphic imaging in 47% (15/32) of patients. In seven cases the anatomical level of SN according to SPECT-CT was reclassified during surgery. The overall incidence of lymph node metastases was 19% (6/32). There were no false negative SNs.
authors.affiliation: Department of Otolaryngology - Head & Neck Surgery, Copenhagen University Hospital, Denmark. bilde@rh.dk
authors.forename: Anders
authors.initials: A
authors.lastname: Bilde
authors.forename: Christian
authors.initials: C
authors.lastname: Von Buchwald
authors.forename: Jann
authors.initials: J
authors.lastname: Mortensen
authors.forename: Jens
authors.initials: J
authors.lastname: Marving
authors.forename: Marianne
authors.initials: M
authors.lastname: Hamilton Therkildsen
authors.forename: Jørgen
authors.initials: J
authors.lastname: Kirkegaard
authors.forename: Birgitte
authors.initials: B
authors.lastname: Charabi
authors.forename: Lena
authors.initials: L
authors.lastname: Specht
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D015899:Tomography, Emission-Computed, Single-Photon