Time-kill assay of itraconazole against Malassezia species.
The in vitro pharmacodynamic activity of itraconazole against Malassezia was determined by time-kill methods. Itraconazole showed fungistatic activity at concentrations greater than 2x minimum inhibitory concentration (MIC) for each of the isolates of all nine Malassezia species associated with humans. A concentration exceeding 4x MIC decreased the growth to less than the inoculum amount (1 x 10(5) cells/ml).
Sugita
Takashi
T
Department of Microbiology, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan. sugita@my-pharm.ac.jp
Tsubuku
Hisae
H
Tajima
Mami
M
Tsuboi
Ryoji
R
Nishikawa
Akemi
A
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000494:pharmacology*; D008290:Malassezia / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D017964:Itraconazole