Idiopathic thrombocytopenic purpura (ITP): is there a genetic predisposition?
Idiopathic thrombocytopenic purpura (ITP) is a diagnosis of exclusion. It is unknown, whether familial ITP exists. Familial cases would make a genetic susceptibility for ITP possible. Data of the Pediatric and Adult Registry on Chronic ITP (PARC-ITP) were reviewed and subsequently ITP patients from Basel investigated for cases with a positive family history. In 10 of 445 pediatric patients and in 2 of 21 patients from Basel the family history was positive. A surprisingly high number of ITP patients with a positive family history were identified, indicating the likely existence of a genetic susceptibility for ITP.
Rischewski
Johannes R
JR
Department of Pediatric Oncology/Hematology, University Children's Hospital Basel (UKBB), Basel, Switzerland. johannes.rischewski@ukbb.ch
Imbach
Paul
P
Paulussen
Michael
M
Kühne
Thomas
T
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000235:genetics*