title: End-tidal carbon monoxide measurements in infant respiratory distress syndrome.
abstract: BACKGROUND
  RDS involving inflammatory and oxidative processes may lead to increased production of carbon monoxide (CO).
  
  
  OBJECTIVE
  The relationship between end-tidal CO, corrected for inhaled CO (ETCOc), and RDS severity was investigated in preterm infants as well as the value of early ETCOc measurements to predict chronic lung disease.
  
  
  METHODS
  78 infants (30 no RDS, 32 moderate RDS, 16 severe RDS) were included. ETCOc was measured using the CO-Stat End Tidal Breath Analyzer.
  
  
  RESULTS
  ETCOc was significantly higher in RDS compared to no RDS during the first week (p<0.05). Severity of RDS was the most significant independent variable in a stepwise regression model related to ETCOc (F-test: 18.17). Negative predictive value of early (within first 12 h of life) ETCOc measurement (<2.5 ppm) for development of chronic lung disease was excellent (100%).
  
  
  CONCLUSIONS
  During severe RDS, inflammation may contribute to increased lipid peroxidation leading to increased local CO production in the lung, indicated by increased ETCOc. Early ETCOc determinations may be helpful to exclude occurrence of chronic lung disease.
authors.affiliation: Department of Neonatology, Wilhemina Children's Hospital, University Medical Center, Utrecht, the Netherlands. t.krediet@wkz.azu.nl
authors.forename: Tannette G
authors.initials: TG
authors.lastname: Krediet
authors.forename: Geert A
authors.initials: GA
authors.lastname: Cirkel
authors.forename: Hendrik J
authors.initials: HJ
authors.lastname: Vreman
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Wong
authors.forename: David K
authors.initials: DK
authors.lastname: Stevenson
authors.forename: Floris
authors.initials: F
authors.lastname: Groenendaal
authors.forename: Johannes
authors.initials: J
authors.lastname: Egberts
authors.forename: Frank
authors.initials: F
authors.lastname: Van Bel
mesh_terms: D001944:Breath Tests; D002248:Carbon Monoxide / Q000378:metabolism*; D002908:Chronic Disease; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000175:diagnosis; D011379:Prognosis; D012127:Respiratory Distress Syndrome, Newborn / Q000378:metabolism*
chemical_list: D002248:Carbon Monoxide