title: Concomitant bone marrow metastasis of a glioblastoma multiforme revealed at the diagnosis.
abstract: The rare occurrence of extra-neural metastases in patients having a tumour of the central nervous system (CNS) could mean that the symptoms of a metastatic lesion are confused with a second pathology. We recently treated a patient with a glioblastoma multiforme who was developing a pancytopaenia at the initial diagnosis. The frequent red cell and platelet transfusions were transitorily active. An extensive radiological investigation and a unilateral iliac bone marrow aspirate and biopsy were performed. Cells immunoreactive to glial fibrillary acidic protein were detected in a specimen obtained from the iliac bone. Post-mortem examination confirmed metastasis to extra-cranial bone and revealed other metastases in lung, mediastinal lymph node and spleen. Therefore, in patients with malignant glioma tumours, bone marrow metastasis, though not common, should be investigated when bone pain or cytopaenia occur.
authors.affiliation: Neuro-Oncologie - Neurologie, CHU de Nancy, Hôpital Central, France.
authors.forename: A
authors.initials: A
authors.lastname: Didelot
authors.forename: L
authors.initials: L
authors.lastname: Taillandier
authors.forename: Y
authors.initials: Y
authors.lastname: Grignon
authors.forename: H
authors.initials: H
authors.lastname: Vespignani
authors.forename: P
authors.initials: P
authors.lastname: Beauchesne
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology* / Q000503:physiopathology; D019046:Bone Marrow Neoplasms / Q000175:diagnosis / Q000556:secondary*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D017809:Fatal Outcome; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000378:metabolism; D005909:Glioblastoma / Q000175:diagnosis / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008297:Male; D010148:Intractable Pain / Q000188:drug therapy / Q000209:etiology; D010198:Pancytopenia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000556:secondary*
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein