title: Legeais BioKpro III keratoprosthesis implantation: long term results in seven patients.
abstract: OBJECTIVE
  The long term results of the Legeais BioKpro III keratoprosthesis are presented for seven patients with severe corneal scarring.
  
  
  METHODS
  The study took place at Moorfields Eye Hospital, London. Patients had either end stage ocular surface disease or corneal opacification after multiple failed graft surgery, with the potential for significant visual improvement. After insertion the device was covered with a conjunctival flap or buccal mucous membrane graft, which was later opened to expose the optic. The outcome measures were vision, complications, and retention of the device.
  
  
  RESULTS
  The BioKpro III was inserted into seven patients with severe corneal scarring: ocular cicatricial pemphigoid, measles keratitis, thermal injury, Stevens-Johnson syndrome, aniridia, chemical injury, and congenital rubella. The follow up was 18-48 months. The keratoprosthesis failed in six, because of extrusion occurring 2-28 months postoperatively. Retroprosthetic membranes occurred in three patients, and endophthalmitis in one. Vision improved from hand movements to 6/12 in the only patient who retained the KPro; however he was troubled by mucus accumulation on the optic.
  
  
  CONCLUSIONS
  The one success has been in a patient with thermal burns. The remaining results have been poor, with the KPro extruding in six of the seven patients.
authors.affiliation: Department of Ophthalmology, King's College Hospital, Denmark Hill, London SE5 9RS, UK. emma.hollick@kingsch.nhs.uk
authors.forename: E J
authors.initials: EJ
authors.lastname: Hollick
authors.forename: S L
authors.initials: SL
authors.lastname: Watson
authors.forename: J K G
authors.initials: JK
authors.lastname: Dart
authors.forename: P J
authors.initials: PJ
authors.lastname: Luthert
authors.forename: B D S
authors.initials: BD
authors.lastname: Allan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002921:Cicatrix / Q000601:surgery; D003318:Corneal Opacity / Q000473:pathology / Q000601:surgery*; D016039:Corneal Transplantation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011475:Prosthesis Failure; D019919:Prosthesis Implantation / Q000379:methods*; D016896:Treatment Outcome