Direct, palladium-catalyzed, multicomponent synthesis of beta-lactams from imines, acid chloride, and carbon monoxide.
A new palladium-catalyzed synthesis of 3-amido-substituted beta-lactams is reported. This process involves the one-pot coupling of four components, imines, carbon monoxide, and acid chloride, providing a flexible route to construct this class of heterocycle. The generation of beta-lactams with two different imines can also be accomplished, providing a method to assemble these products with independent control over five separate substituents.
Dhawan
Rajiv
R
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
Dghaym
Rania D
RD
St Cyr
Daniel J
DJ
Arndtsen
Bruce A
BA
D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D047090:beta-Lactams / Q000138:chemical synthesis*
D002712:Chlorides; D007097:Imines; D047090:beta-Lactams; D010165:Palladium; D002248:Carbon Monoxide