The evidence for medicine versus surgery for carotid stenosis.
Atherosclerotic stenosis of the internal carotid artery is an important cause of stroke. Several large randomised trials have compared best medical management with carotid endarterectomy and provide a strong evidence base for advising and selecting patients for carotid surgery. Best medical management of carotid stenosis includes lowering of blood pressure, treatment with statins and antiplatelet therapy in symptomatic patients. Combined analysis of the symptomatic carotid surgery trials, together with observational data, has shown that patients with recently symptomatic severe carotid stenosis have a very high risk of recurrent stroke in the first few days and weeks after symptoms. Carotid endarterectomy has a risk of causing stroke or death at the time of surgery in symptomatic patients of around 5-7%, but in patients with recently symptomatic stenosis of more than 70%, the benefits of endarterectomy outweigh the risks. In patients with moderate stenosis of between 50 and 69%, the benefits may justify surgery in patients with very recent symptoms, and in patients older than 75 years within a few months of symptoms. Patients with less than 50% stenosis do not benefit from surgery. In asymptomatic patients, or those whose symptoms occurred more than 6 months ago, the benefits of surgery are considerably less. Patients with asymptomatic stenosis treated medically only have a small risk of future stroke when treated medically of about 2% per annum. If carotid endarterectomy can be performed safely with a perioperative stroke and death rate of no more than 3%, then the randomised trials showed a significant benefit of surgery over 5 years follow-up, with an overall reduction in the risk of stroke from about 11% over 5 years down to 6%. However, of 100 patients operated, only 5 will benefit from avoiding a stroke over 5 years. The majority of neurologists have concluded that this does not justify a policy of routine screening and endarterectomy for asymptomatic stenosis. Patients known to have asymptomatic stenosis should be advised of the risks and benefits. The trials provide justification for surgery at centres with a proven low complication rate, in asymptomatic patients prepared to take a small immediate risk in exchange for a small longer term benefit. Those that opt for medical management alone should be advised to seek urgent medical attention should they become symptomatic in the future.
Ederle
Jörg
J
Stroke Research Group, UCL Institute of Neurology, London, UK.
Brown
Martin M
MM
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016893:Carotid Stenosis / Q000453:epidemiology* / Q000628:therapy*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D016894:Endarterectomy, Carotid / Q000706:statistics & numerical data*; D019317:Evidence-Based Medicine / Q000706:statistics & numerical data; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010818:Practice Patterns, Physicians'; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D010975:Platelet Aggregation Inhibitors