Studies on Ocimum gratissimum seed mucilage: evaluation of binding properties.
Mucilage extracted from Ocimum gratissimum seeds, inertness and safety parameters established by a previous study was subjected to preformulation trial to assess its suitability as a pharmaceutical binder. Properties of the granules prepared with calcium carbonate using different concentrations of ocimum and compared with acacia (5%, w/w), as standard. Ocimum at 2.3% (w/w) level was found to be comparable with 5% (w/w) of acacia. Effect on drug release studied with paracetamol indicated that ocimum mucilage could be an alternative to acacia.
Anroop
B
B
PES College of Pharmacy, 50 Feet Road, Hanumanth Nagar, Bangalore, Karnataka, India. banroop@rediffmail.com
Ghosh
B
B
Parcha
V
V
Vasanti
S
S
D000082:Acetaminophen / Q000737:chemistry / Q000493:pharmacokinetics; D000269:Adhesives / Q000302:isolation & purification*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000493:pharmacokinetics; D002119:Calcium Carbonate / Q000737:chemistry; D045703:Emulsifying Agents / Q000737:chemistry; D006170:Gum Arabic / Q000737:chemistry; D007700:Kinetics; D031339:Ocimum / Q000737:chemistry*; D015203:Reproducibility of Results; D012639:Seeds / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods / Q000592:standards
D000269:Adhesives; D018712:Analgesics, Non-Narcotic; D045703:Emulsifying Agents; D000082:Acetaminophen; D006170:Gum Arabic; D002119:Calcium Carbonate