Genetic polymorphism of interferon-gamma, interferon-gamma receptor, and interferon regulatory factor-1 genes in patients with hepatitis B virus infection.
The natural history of hepatitis B virus (HBV) infection is probably related to host immune factors. Interferon-gamma (IFN-gamma) plays significant roles in immune defense. This study was undertaken to investigate the association between HBV infection and single nucleotide polymorphisms (SNPs) of IFN-gamma, IFN-gamma receptor (IFNGR)-1 and 2, and interferon regulatory factor (IRF)-1 genes. Between March 2002 and December 2002, 614 Korean patients were enrolled in two different groups: an HBV clearance group (n = 201), who were hepatitis B surface antigen (HBsAg) negative with antibodies to HBsAg and hepatitis B core antigen, and an HBV persistence group (n = 413), who were repeatedly HBsAg positive. We assessed polymorphisms in the IFN-gamma gene at position +874, in the IFNGR-1 gene at positions -56 and +95, in the IFNGR-2 gene at the second position of codon 64 (Gln64Arg), and in the IRF-1 gene promoter (-410, -388), and the genotype distributions of the HBV clearance and persistence groups were compared. On the basis of unconditional logistic regression analysis with adjustment for age and sex, no statistically significant association with susceptibility to persistent HBV infection was observed with the IFN-gamma, IFNGR-1 and 2, and IRF-1 gene polymorphisms under the codominant, dominant, and recessive models.
Cheong
Jae Youn
JY
Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, San-5 Wonchon-Dong, Youngtong-ku, Suwon, South Korea.
Cho
Sung Won
SW
Chung
Soon Gee
SG
Lee
Jung A
JA
Yeo
Marie
M
Wang
Hee Jung
HJ
Lee
Jong Eun
JE
Hahm
Ki Baik
KB
Kim
Jin Hong
JH
D000293:Adolescent; D000328:Adult; D000368:Aged; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D005260:Female; D006509:Hepatitis B / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D006801:Humans; D050856:Interferon Regulatory Factor-1 / Q000235:genetics*; D007371:Interferon-gamma / Q000235:genetics*; D007723:Korea; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D017471:Receptors, Interferon / Q000235:genetics*; D000096743:Interferon gamma Receptor
D017931:DNA Primers; D050856:Interferon Regulatory Factor-1; D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor; C086185:IFNGR2 protein, human; C494257:IRF1 protein, human