title: Intraindividual propofol dosage variability in children undergoing repetitive procedural sedations.
abstract: The authors prospectively assessed intraindividual variability in propofol dosage for induction of sedation in repetitive procedures in children with malignancies. A total of 80 procedures were performed in 24 children. Primary outcome measure was the intraindividual propofol dose required to achieve adequate sedation. Intraindividual variability in propofol dosage required to achieve adequate sedation was 0.0-2.2 mg.kg-1. Twenty-five percent of the patients had a dose range of 0.0-0.5 mg x kg-1; 37.5%, >0.5-1.0 mg x kg-1; and 37.5% >1.0-2.2 mg x kg-1. Due to remarkable intraindividual differences, propofol dosage should be titrated toward the desired level of sedation.
authors.affiliation: University Children's Hospital, Department of Pediatric Hematology and Oncology, University of the Saarland, Homburg, Germany. kisgot@uniklinik-saarland.de
authors.forename: Sven
authors.initials: S
authors.lastname: Gottschling
authors.forename: Sascha
authors.initials: S
authors.lastname: Meyer
authors.forename: Harald
authors.initials: H
authors.lastname: Reinhard
authors.forename: Rhoikos
authors.initials: R
authors.lastname: Furtwängler
authors.forename: Daniel
authors.initials: D
authors.lastname: Klotz
authors.forename: Norbert
authors.initials: N
authors.lastname: Graf
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol