Why does chloroquine impair renal function?: chloroquine may modulate the renal tubular response to vasopressin either directly by inhibiting cyclic AMP generation, or indirectly via nitric oxide.
Chloroquine is one of the antimalaria drugs, also used to treat rheumatoid arthritis and systemic lupus erythematosus (SLE). Although well tolerated in most individuals, it was suggested that chloroquine can exert a profound influence on renal function, especially in individuals with compromised body fluid status. However, epidemiological studies are still lacking. The renal actions of chloroquine are further exacerbated by co-administration of other commonly used drugs such as paracetamol. The following discussion will focus on the evidence that chloroquine is a stimulator of nitric oxide (NO), which mediates many of its renal actions (diuresis, natriuresis and an increase in both glomerular filtration rate (GFR) and plasma vasopressin). Chloroquine appears to modulate the renal tubular response to vasopressin either by directly inhibiting cAMP generation or indirectly via NO.
Ahmed
Mohamed H
MH
Chemical Pathology Department, Southampton General Hospital, Tremona Road, Southampton, Hamphshire SO16 6YD, UK. elziber@yahoo.com
Osman
Meissa M
MM
D000818:Animals; D000962:Antimalarials / Q000009:adverse effects; D002738:Chloroquine / Q000009:adverse effects*; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000378:metabolism*; D014667:Vasopressins / Q000378:metabolism*
D000962:Antimalarials; D014667:Vasopressins; D009569:Nitric Oxide; D002738:Chloroquine; D000242:Cyclic AMP