Enantioselective transfer aminoallylation: synthesis of optically active homoallylic primary amines.
A camphorquinone-derived chiral homoallylic amine was found to react with various aldehydes via imine formation and asymmetric 2-azonia-Cope rearrangement to give optically active homoallylic primary amines. A practical level of enantioselectivity with high functional group tolerance has been attained in this transformation.
Sugiura
Masaharu
M
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Mori
Chieko
C
Kobayashi
Shu
S
D000588:Amines / Q000737:chemistry*; D013237:Stereoisomerism
D000588:Amines