title: Extra-oral plasmablastic lymphoma: report of a case and review of literature.
abstract: Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma cells were positive for CD138 and weakly positive for CD79a. In addition, these cells were also positive for CD10. The neoplastic cells were positive for Epstein-Barr virus and negative for human herpes virus 8. Review of the English medical literature revealed many more cases of extra-oral PBL. We propose that the term plasmablastic lymphoma of the oral cavity in World Health Organization classification be revised to simply plasmablastic lymphoma, which would include both oral and extra-oral PBLs, and the term to define the primary site of the lymphoma (ie, oral cavity) be dropped from the terminology used in World Health Organization classification.
authors.affiliation: Department of Pathology, University of Maryland School of Medicine, Baltimore, 21201, USA.
authors.forename: Fabio
authors.initials: F
authors.lastname: Tavora
authors.forename: Luis F
authors.initials: LF
authors.lastname: Gonzalez-Cuyar
authors.forename: Chen-Chih J
authors.initials: CC
authors.lastname: Sun
authors.forename: Allen
authors.initials: A
authors.lastname: Burke
authors.forename: X Frank
authors.initials: XF
authors.lastname: Zhao
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000145:classification* / Q000378:metabolism / Q000473:pathology*; D051925:CD79 Antigens / Q000378:metabolism; D020031:Epstein-Barr Virus Infections / Q000150:complications; D015658:HIV Infections / Q000150:complications; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D016393:Lymphoma, B-Cell / Q000145:classification* / Q000378:metabolism / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D015260:Neprilysin / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism; D053668:Syndecan-1; D053667:Syndecans
chemical_list: D051925:CD79 Antigens; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans; D015260:Neprilysin