title: A novel, antimicrobially active analog of gramicidin S without amphiphilic conformation.
abstract: A novel gramicidin S analog, cyclo(-Val-Leu-Leu-Orn-Leu-D-Phe-Pro-)2, was synthesized, its antibiotic activity compared with gramicidin S and shown to be as potent as gramicidin S when compared with the susceptibility toward five Gram-positive microorganisms. It exceeded the activity of gramicidin S against Bacillus megaterium ATCC 19213 by a factor of two. Circular dichroism and NMR data suggested this analog to adopt an antiparallel beta-sheet conformation without amphiphilic character.
authors.forename: Makoto
authors.initials: M
authors.lastname: Tamaki
authors.forename: Kenta
authors.initials: K
authors.lastname: Sawa
authors.forename: Sho
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Mitsuno
authors.initials: M
authors.lastname: Shindo
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Uchida
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006096:Gramicidin / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D017433:Protein Structure, Secondary; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006096:Gramicidin