Intralesional therapy of metastatic spreading melanoma with beta-interferon.
A 74-year-old female patient developed multiple local metastases after excision of a nodular melanoma of the left cheek. There was no regression after treatment with dacarbazine (DTIC) and radiotherapy. After treatment with intralesional interferon-beta, the metastases regressed completely. The dosage was 5 million IU interferon-beta (Fiblaferon) three times weekly with courses of two and four weeks, separated by a month. Except for local swelling and inflammation, no side effects occurred. Five years after completing therapy, the patient is still tumor-free.
Rapprich
Harriet
H
Department of Dermatology, Klinikum Darmstadt, Darmstadt, Germany. stefan.rapprich@klinikum-darmstadt.de
Hagedorn
Manfred
M
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D005153:Facial Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D016899:Interferon-beta / Q000008:administration & dosage*; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D016899:Interferon-beta