Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol.
Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.
Basaraba
Randall J
RJ
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1619, USA. basaraba@colostate.edu
Smith
Erin E
EE
Shanley
Crystal A
CA
Orme
Ian M
IM
D000336:Aerosols; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D042601:Lymphatic Vessels / Q000382:microbiology* / Q000473:pathology*; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000473:pathology*
D000336:Aerosols