4-difluoro-substituted phenl-5-oxohexahydroquinoline derivatives and their effects on calcium channels.
Twenty new methyl(ethyl) 2,6,6- or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates and ten new N,N-diethyl-2,6,6- or 2,7,7-trimethyl-5-oxo-4-(disubstituted phenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide derivatives have been synthesised and screened for their calcium channel antagonistic activity. The compounds were synthesised by the Hantzsch reaction. Calcium antagonistic activities of the compounds were determined by the tests performed on isolated rat ileum and rat thoracic artery.
Simşek
Rahime
R
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. rsimsek@hacettepe.edu.tr
Gündüz
Miyase Gözde
MG
Sirmagül
Başar
B
Safak
Cihat
C
Erol
Kevser
K
Linden
Anthony
A
D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D008297:Male; D008958:Models, Molecular; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013895:Thoracic Arteries / Q000187:drug effects
D002121:Calcium Channel Blockers; D007202:Indicators and Reagents; D011804:Quinolines