Comparison of butyl-2-cyanoacrylate, gelatin-resorcin-formaldehyde (GRF) compound and suture in stabilization of cartilage grafts in rabbits.
Cartilage grafting is an interesting option for rhinoplasties refinements.


OBJECTIVE
To compare butyl-2-cyanoacrylate, compound gelatin-resorcin-formaldehyde (GRF) and suture control to determine the efficacy of these tissue glue preparations in securing grafted cartilage.


METHODS
Experimental.


METHODS
Fifteen male adult New Zealand rabbits were submitted to a surgical procedure to harvest 6 auricular cartilage grafts from each animal. 2 of these grafts in each animal were glued together with butyl-2-cyanoacrylate, 2 with compound gelatin-resorcin-formaldehyde and 2 sewn together with nylon suture. These sandwich grafts were then glued or sewn to the periosteum of the calvaria. After 2, 6 and 12 weeks, groups of 5 animals were sacrificed and histological analysis for inflammation was performed. Cartilage graft migration, adhesion and deformities of the grafts were also evaluated.


RESULTS
There was less migration of the cartilages glued with GRF than with cyanoacrylate and suture. There was no statistical difference between the 3 materials of graft stabilization in relation to the inflammatory reaction in all evaluated periods. There wasn't detachment neither deformity in the cartilage sandwiches sewn with suture. The majority of detachment and deformed cartilages were found among those glued with cyanoacrylate. The number of deformed cartilages was directly related to the number of detached cartilages. The data were statistically significant (p< 0.05).


CONCLUSIONS
The compound gelatin-resorcin-formaldehyde revealed to be a stabilization material for cartilage grafts in rabbits better than butyl-2-cyanoacrylate. The compound gelatin-resorcin-formaldehyde was also better than the suture when comparing its fixation to the periosteum.
Costa
Heloisa Juliana Zabeu Rossi
HJ
FCM Santa Casa de São Paulo, Brazil.
Pereira
Celina Siqueira Barbosa
CS
Costa
Márcio Paulino
MP
Fabri
Fabrício Sanchez Soga Sanches
FS
Lancellotti
Carmen Lúcia Penteado
CL
Dolci
José Eduardo Lutaif
JE
D000818:Animals; D004338:Drug Combinations; D004425:Ear Cartilage / Q000473:pathology / Q000637:transplantation*; D004659:Enbucrilate / Q000627:therapeutic use*; D005557:Formaldehyde / Q000627:therapeutic use*; D005780:Gelatin / Q000627:therapeutic use*; D006085:Graft Survival; D008297:Male; D011817:Rabbits; D012118:Resorcinols / Q000627:therapeutic use*; D013536:Suture Techniques; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*
D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin; D004659:Enbucrilate