title: Translocation (10;11)(p12;q23) in childhood acute myeloid leukemia: incidence and complex mechanism.
abstract: Using both conventional and molecular cytogenetic methods, we found five new cases of t(10;11)(p12;q23). This translocation represented 28% of all cases of childhood AML treated at our center in 2004, and 63% of AML with rearrangements of 11q23. We describe three mechanisms for the translocation. Different fragments of 11q were involved in four of the five cases. One patient showed a cytogenetically cryptic insertion of 5' part of MLL into the 3' part of MLLT10 in 10p12. The median event-free survival of patients was 8.1 months, and we conclude that the t(10;11)(p12;q23) is associated with unfavorable prognosis in childhood acute myeloid leukemia.
authors.affiliation: Research Center for Pediatric Oncology and Hematology, 223040, Minsk Region, p. Lesnoi, Belarus. istasevich@yahoo.com
authors.forename: Irina
authors.initials: I
authors.lastname: Stasevich
authors.forename: Regina
authors.initials: R
authors.lastname: Utskevich
authors.forename: Anatoly
authors.initials: A
authors.lastname: Kustanovich
authors.forename: Natallia
authors.initials: N
authors.lastname: Litvinko
authors.forename: Tatsiana
authors.initials: T
authors.lastname: Savitskaya
authors.forename: Svetlana
authors.initials: S
authors.lastname: Chernyavskaya
authors.forename: Olga
authors.initials: O
authors.lastname: Saharova
authors.forename: Olga
authors.initials: O
authors.lastname: Aleinikova
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic