title: Splenectomy in children with chronic ITP: long-term efficacy and relation between its outcome and responses to previous treatments.
abstract: This retrospective study was conducted to determine whether the response to splenectomy is related to the response to previous treatments. We examined the records of 90 children splenectomized for chronic ITP. Platelet counts were constantly>50x10(9)/L in 68 patients (75%). An improvement in the quality of life was observed in 79 (85%). The success of splenectomy was strongly correlated with a good response to previous treatment. A negative response to any of the prior treatments had no predictive value. This finding is relevant when elective splenectomy is considered as a treatment option.
authors.affiliation: Department of Pediatrics, University of Torino, Torino, and Department of Pediatrics, Umberto I hospital, Nocera Inferiore, Italy. ugo.ramenghi@unito.it
authors.forename: Ugo
authors.initials: U
authors.lastname: Ramenghi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Amendola
authors.forename: Loredana
authors.initials: L
authors.lastname: Farinasso
authors.forename: Paola
authors.initials: P
authors.lastname: Giordano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Loffredo
authors.forename: Bruno
authors.initials: B
authors.lastname: Nobili
authors.forename: Silverio
authors.initials: S
authors.lastname: Perrotta
authors.forename: Giovanna
authors.initials: G
authors.lastname: Russo
authors.forename: Marco
authors.initials: M
authors.lastname: Zecca
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007223:Infant; D007518:Isoantibodies / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D011788:Quality of Life; D012189:Retrospective Studies; D018029:Rho(D) Immune Globulin; D013156:Splenectomy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin