Evaluation of MMP3 and TIMP1 as candidate genes for high myopia in young Taiwanese men.
OBJECTIVE
We studied the relationship between high myopia and the MMP3 and TIMP1 genes.


METHODS
Case-control study.


METHODS
We enrolled 150 high myopic individuals (< or = -6 diopters) and 262 controls (> or = -1.5 diopters) initially, and another 216 cases and 474 controls were enrolled for genotyping promising polymorphisms for replication. Thirteen polymorphisms were genotyped in the initial data. Logistic regression was used to test for genetic effects. Subset analyses were performed according to the education level and family history.


RESULTS
There was no significant association between any polymorphism and high myopia in the initial data. Among the highly educated subjects, the 5A/6A polymorphism at the MMP3 gene suggested a potential relationship with high myopia, and it was genotyped in the follow-up samples. However, this polymorphism failed to show any significant results in the overall subjects.


CONCLUSIONS
The two genes may not play a crucial role for high myopia in young Taiwanese men.
Liang
Chung-Ling
CL
Bright-Eye Clinic, Kaohsiung, Taiwan.
Wang
Hsin-Shih
HS
Hung
Kuo-Sheng
KS
Hsi
Edward
E
Sun
Angel
A
Kuo
Yi-Hui
YH
Juo
Suh-Hang Hank
SH
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004522:Educational Status; D005838:Genotype; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3; D045726:Metalloproteases / Q000235:genetics*; D009216:Myopia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics*
D019715:Tissue Inhibitor of Metalloproteinase-1; D045726:Metalloproteases; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3