Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.
The catecholic xanthones and flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.
Park
Ki Hun
KH
National Research Laboratory of Lipid Metabolism and Atherosclerosis, Insect Resources Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 3806, Republic of Korea.
Park
Yong-Dae
YD
Han
Jong-Min
JM
Im
Kyung-Ran
KR
Lee
Byong Won
BW
Jeong
Il Yun
IY
Jeong
Tae-Sook
TS
Lee
Woo Song
WS
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D050197:Atherosclerosis / Q000188:drug therapy*; D002396:Catechols / Q000494:pharmacology*; D002460:Cell Line; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D029586:Moraceae; D044004:Xanthones / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D002396:Catechols; D005419:Flavonoids; D044004:Xanthones