title: Muscle metabolites: functional MR spectroscopy during exercise imposed by tetanic electrical nerve stimulation.
abstract: Permission from the ethics committee and informed consent were obtained. The purpose of this study was to prospectively evaluate a method developed for the noninvasive assessment of muscle metabolites during exercise. Hydrogen 1 magnetic resonance (MR) spectroscopy peaks were measured during tetanic isometric muscle contraction imposed by supramaximal repetitive nerve stimulation. The kinetics of creatine-phosphocreatine and acetylcarnitine signal changes (P < .001) could be assessed continuously before, during, and after exercise. The control peak (trimethylammonium compounds), which served as an internal reference, did not change. This technique-that is, functional MR spectroscopy-opens the possibility for noninvasive diagnostic muscle metabolite testing in a clinical setting.
authors.affiliation: Department of Neurology, University Hospital, Inselspital, CH-3010 Bern, Switzerland. anirkko@insel.ch
authors.forename: Arto C
authors.initials: AC
authors.lastname: Nirkko
authors.forename: Kai M
authors.initials: KM
authors.lastname: Rösler
authors.forename: Johannes
authors.initials: J
authors.lastname: Slotboom
mesh_terms: D000108:Acetylcarnitine / Q000032:analysis; D000328:Adult; D003401:Creatine / Q000032:analysis; D004558:Electric Stimulation; D015444:Exercise; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology*; D009132:Muscles / Q000378:metabolism*; D010725:Phosphocreatine / Q000032:analysis; D011446:Prospective Studies
chemical_list: D010725:Phosphocreatine; D000108:Acetylcarnitine; D003401:Creatine