The use of serum biomarkers to predict outcome after traumatic brain injury in adults and children.
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in adults and children. Predicting outcome after TBI is difficult, but it is important for acute management, counseling of family members, and provision of rehabilitation services. Serum biomarkers may be useful alone or in combination with clinical variables to predict outcome after TBI. This article reviews the potential uses of serum biomarkers for the clinician, current literature related to the use of serum biomarkers for outcome prediction after adult and pediatric TBI, limitations of the literature, and future direction for this field.
Berger
Rachel Pardes
RP
Department of Pediatrics, Division of Child Advocacy, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA. rberger@pitt.edu
D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood*; D015600:Glasgow Coma Scale; D005904:Glial Fibrillary Acidic Protein / Q000097:blood*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000097:blood*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D010751:Phosphopyruvate Hydratase / Q000097:blood*
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins; D010751:Phosphopyruvate Hydratase