title: Floppy iris behaviour during cataract surgery: associations and variations.
abstract: OBJECTIVE
  To assess the association of floppy iris behaviour during cataract surgery with use of alpha-1-antagonists and diabetes mellitus.
  
  
  METHODS
  1842 eyes of 1786 patients undergoing phacohoemulsification surgery were prospectively enrolled. The use of commonly prescribed alpha-1-antagonists and the presence or absence of diabetes mellitus were noted. The occurrence of any of the features of the intraoperative floppy iris syndrome (IFIS) was noted by surgeons blinded to the patient's history.
  
  
  RESULTS
  57% of patients receiving tamsulosin showed features of IFIS compared with 1% of the non-tamsulosin group (p<0.001). Of these, more than half the patients manifested the syndrome in an incomplete form. Only 1 of the 51 patients receiving other alpha-1-antagonists had IFIS. Diabetes was also not associated with IFIS (p = 1).
  
  
  CONCLUSIONS
  Tamsulosin is significantly associated with floppy iris behaviour during cataract surgery. But not all of these patients will necessarily show all or any features of IFIS. The floppy iris syndrome is likely to represent a continuum of severity. Various undefined factors, diabetes not being one of them, may have a contributory role. Non-selective alpha-1-antagonists are unlikely to be associated with IFIS.
authors.affiliation: Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh EH3 9HA, UK. vchdh@aol.com
authors.forename: V
authors.initials: V
authors.lastname: Chadha
authors.forename: S
authors.initials: S
authors.lastname: Borooah
authors.forename: A
authors.initials: A
authors.lastname: Tey
authors.forename: C
authors.initials: C
authors.lastname: Styles
authors.forename: J
authors.initials: J
authors.lastname: Singh
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects*; D002387:Cataract Extraction; D048909:Diabetes Complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D007498:Iris / Q000187:drug effects / Q000503:physiopathology; D007499:Iris Diseases / Q000150:complications / Q000503:physiopathology*; D008297:Male; D011391:Prolapse; D011446:Prospective Studies; D011680:Pupil; D012008:Recurrence; D013449:Sulfonamides / Q000009:adverse effects; D013577:Syndrome; D000077409:Tamsulosin
chemical_list: D000317:Adrenergic alpha-Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin