title: Effect of heparin-bonded central venous catheters on the incidence of catheter-related thrombosis and infection in children and adults.
abstract: The use of central venous catheters, while advantageous, is associated with a range of complications including thrombosis and infection. These complications can pose significant physical and financial costs to the patient and health care system. A critical appraisal of the two randomized controlled trials examining this topic in critically ill patients has shown that heparin-bonded central venous catheters significantly reduced the incidence of catheter-related thrombosis and infection in children and adults. These findings suggest that heparin-bonded central venous catheters should be considered for routine use in critically ill patients.
authors.affiliation: Royal Children's Hospital, Brisbane, Queensland, Australia.
authors.forename: D A
authors.initials: DA
authors.lastname: Long
authors.forename: M G
authors.initials: MG
authors.lastname: Coulthard
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation*; D002648:Child; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D006493:Heparin