title: Conjunctival low-grade non-Hodgkin's lymphoma: a large single-center study of initial characteristics, natural history and prognostic factors.
abstract: To define the initial characteristics and prognostic factors of patients with conjunctival low-grade malignant lymphoma, all patients treated for low-grade lymphoma with initial conjunctival involvement were reviewed. Forty-nine cases were selected, including 45 cases with exclusive ophthalmologic conjunctival involvement. Pathologic review showed 55% of mucosa-associated lymphoid tissue type lymphoma, and 23% of lymphoplasmocytic lymphoma. Initial characteristics were median age of 62 years, nodal involvement in 17% of cases, and stage IV in 22% of patients with 10% of bone marrow involvement. With a median follow-up of 75 months, the 5-year disease-free survival (DFS) and overall survival were 65% and 83%, respectively. On multivariate analysis, nodal involvement was the only factor with a pejorative impact on DFS. Our patient cohort represents one of the largest published series defining the characteristics and prognostic factors of primary conjunctival low-grade malignant lymphoma.
authors.affiliation: Department of Clinical Hematology, Institut Curie, Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Meunier
authors.forename: Livia
authors.initials: L
authors.lastname: Lumbroso-Le Rouïc
authors.forename: Rémi
authors.initials: R
authors.lastname: Dendale
authors.forename: Anne
authors.initials: A
authors.lastname: Vincent-Salomon
authors.forename: Bernard
authors.initials: B
authors.lastname: Asselain
authors.forename: Philippe
authors.initials: P
authors.lastname: Arnaud
authors.forename: Fariba
authors.initials: F
authors.lastname: Némati
authors.forename: Alain
authors.initials: A
authors.lastname: Fourquet
authors.forename: Laurence
authors.initials: L
authors.lastname: Desjardins
authors.forename: Corine
authors.initials: C
authors.lastname: Plancher
authors.forename: Christine
authors.initials: C
authors.lastname: Levy
authors.forename: Driss
authors.initials: D
authors.lastname: Chaoui
authors.forename: Patricia
authors.initials: P
authors.lastname: Validire
authors.forename: Didier
authors.initials: D
authors.lastname: Decaudin
mesh_terms: D000367:Age Factors; D003230:Conjunctival Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome