title: Intensified and daily hemodialysis in children might improve statural growth.
abstract: In children conventional hemodialysis does not often improve growth. We determined linear growth in five children on in-center intensified and daily hemodialysis (IDd) regimen, with a mean age of 8 years 7 months at enrollment. Four of five were on growth hormone started for a median of 28.5 months before IDd. IDd was delivered 5 to 6 times weekly, for three hours each session. Mean follow up of IDd was 18.6 months. Dropout from IDd was kidney transplantation (n=4) or transfer to another center (n=1). IDd and free diet improved appetite, thereby protein intake, was above 2 g/kg/BW. Median weekly Kt/V(urea) was 9.1 (8.7 to 10.4). Predialysis phosphorus blood levels were higher at the start (2.04+/-0.34 mmol/L) than at end of IDd (1.39+/-0.41 mmol/L) without need for carbonate of calcium in four of five cases. During conventional dialysis ht SDS decreased from -0.8 to -1.44, which occurred predominantly before rhGH start. Conversion to IDd significantly increased growth velocity to a mean of 13 cm/year (10.3-18) with a mean change of +1.84 ht SDS/year (0.4 to 2.7). This preliminary report suggests the potential efficacy of IDd regimen in promising growth velocity, either directly from a higher dialysis dose or indirectly through an improved nutritional status.
authors.affiliation: Nephrology Dialysis Transplantation Children's Unit, University Hospital Hautepierre, Avenue Molière, 67098, Strasbourg, France. Michel.Fischbach@chru-strasbourg.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Fischbach
authors.forename: Joëlle
authors.initials: J
authors.lastname: Terzic
authors.forename: Soraya
authors.initials: S
authors.lastname: Menouer
authors.forename: Céline
authors.initials: C
authors.lastname: Dheu
authors.forename: Sylvie
authors.initials: S
authors.lastname: Soskin
authors.forename: Agnès
authors.initials: A
authors.lastname: Helmstetter
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Burger
mesh_terms: D002675:Child, Preschool; D005544:Forecasting; D006128:Growth; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D011446:Prospective Studies; D006435:Renal Dialysis / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome