Comparative study of adult human skin fibroblasts and umbilical fibroblast-like cells.
Expression of markers, collagens, and HLA-1 by human skin fibroblasts and fibroblast-like cells isolated from the umbilical Wharton's jelly was compared. Skin fibroblasts express collagens (proteins characteristic of differentiated cells of this histogenetic series) and HLA-1, while umbilical cells express, in addition to collagens, juvenile surface markers and almost no HLA-1. This indicates that fibroblast-like cells isolated from different sources are different and can serve as sources for the creation of cell preparations with different characteristics in future.
Yarygin
K N
KN
Russian State Medical University.
Suzdal'tseva
Yu G
YG
Burunova
V V
VV
Voronov
A V
AV
Petrakova
N V
NV
Cheglakov
I B
IB
Stupin
V A
VA
Yarygin
V N
VN
D000071916:AC133 Antigen; D000818:Animals; D000941:Antigens / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D024042:Collagen Type I / Q000032:analysis*; D024043:Collagen Type II / Q000032:analysis*; D005260:Female; D005347:Fibroblasts / Q000737:chemistry* / Q000637:transplantation; D006023:Glycoproteins / Q000032:analysis; D015788:HLA-A1 Antigen / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D064231:Nestin; D010455:Peptides / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000166:cytology*; D014470:Umbilical Cord / Q000166:cytology*; D014746:Vimentin / Q000032:analysis; D014841:von Willebrand Factor / Q000276:immunology
D000071916:AC133 Antigen; D000941:Antigens; D015703:Antigens, CD; D018952:Antigens, CD34; D015415:Biomarkers; D024042:Collagen Type I; D024043:Collagen Type II; D006023:Glycoproteins; D015788:HLA-A1 Antigen; D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; C577486:Nes protein, rat; D064231:Nestin; D010455:Peptides; D014746:Vimentin; C029417:Von Willebrand antigen; D014841:von Willebrand Factor