Yersinia pseudotuberculosis adhesins regulate tissue-specific colonization and immune cell localization in a mouse model of systemic infection.
Yersinia pseudotuberculosis mutants deficient for the adhesins invasin and/or YadA were injected intravenously into BALB/c mice. Invasin expression inhibited colonization of the liver and spleen. YadA decreased liver colonization but promoted growth within the lung. The persistence of leukocytes within liver microabscesses correlated with enhanced colonization and lack of adhesin expression.
Hudson
Krischan J
KJ
Department of Microbiology, University of Virginia Health System, Box 800734, 1300 Jefferson Park Ave., Charlottesville, VA 22908-0734, USA.
Bouton
Amy H
AH
D018829:Adhesins, Bacterial / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D000818:Animals; D004195:Disease Models, Animal; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D009504:Neutrophils / Q000276:immunology / Q000382:microbiology; D009928:Organ Specificity / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology; D015011:Yersinia pseudotuberculosis / Q000254:growth & development* / Q000276:immunology*; D015012:Yersinia pseudotuberculosis Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
D018829:Adhesins, Bacterial; C064832:YadA protein, Yersinia; C053476:invasin, Yersinia