title: In silico method for inferring genotypes in pedigrees.
abstract: Our genotype inference method combines sparse marker data from a linkage scan and high-resolution SNP genotypes for several individuals to infer genotypes for related individuals. We illustrate the method's utility by inferring over 53 million SNP genotypes for 78 children in the Centre d'Etude du Polymorphisme Humain families. The method can be used to obtain high-density genotypes in different family structures, including nuclear families commonly used in complex disease gene mapping studies.
authors.affiliation: Department of Pediatrics, University of Pennsylvania, 3516 Civic Center Blvd., Philadelphia, Pennsylvania 19104, USA.
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Burdick
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Chen
authors.forename: Gonçalo R
authors.initials: GR
authors.lastname: Abecasis
authors.forename: Vivian G
authors.initials: VG
authors.lastname: Cheung
mesh_terms: D016009:Chi-Square Distribution; D002648:Child; D002874:Chromosome Mapping; D003198:Computer Simulation; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D020407:Internet; D010375:Pedigree; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers