[Effects of transdermic estrogen therapy, isolated or in association with micronized progesterone, on clotting factors in overweight or normal postmenopausal women].
To evaluate HRT action over hemostasis we treated 45 postmenopausal women, divided in: Group 1 (N= 22, hysterectomized) and Group 2 (N= 23, with uterus), at the average age of 51.6 years and average BMI of 27.1 kg/m(2), with no significant difference in the base-line, with 17beta-oestradiol, 50 mcg/day, transdermic and continuous (group 1) associated to micronized progesterone 200 mg 12 days per month (group 2). The average of 2 samples of TAP, PTT, fibrinogen and platelet number was measured monthly during 3 months. For the total sample, there was a PTT shortening along treatment, from the second evaluation on (p= 0.006). Fibrinogen in Group 2 was significantly higher than in Group 1, from the second evaluation on (p= 0.0005). Patients with BMI > 25 presented a greater TAP shortening (p= 0.040) and a smaller fibrinogen drop (p= 0.033) than patients with BMI < 25. Prothrombotic effects predominated, especially in overweight women and in those who used progesterone.
de Farias
Marilea
M
Setor de Hematologia, Setor de Endocrinologia, Serviço de Clínica Médica, Hospital da Lagoa, Rio de Janeiro, RJ.
Cruz
Lusanere
L
Clapauch
Ruth
R
Siqueira
Claudio
C
D000704:Analysis of Variance; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors; D001780:Blood Coagulation Tests; D015992:Body Mass Index; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D050177:Overweight / Q000502:physiology*; D017698:Postmenopause / Q000097:blood / Q000187:drug effects*; D011374:Progesterone / Q000008:administration & dosage; D018709:Statistics, Nonparametric; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology*
D001779:Blood Coagulation Factors; D004967:Estrogens; D011374:Progesterone