Antiviral activity of substituted homoisoflavonoids on enteroviruses.
The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30.
Tait
Sabrina
S
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Salvati
Anna Laura
AL
Desideri
Nicoletta
N
Fiore
Lucia
L
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002522:Chlorocebus aethiops; D004770:Enterovirus / Q000187:drug effects* / Q000502:physiology; D007529:Isoflavones / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D015394:Molecular Structure; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D007529:Isoflavones