[Distribution of single nucleotide polymorphisms of IL-10 gene in patients with mucoviscidosis].
Distribution of interleukin-10 promoter-1082 G-->A single nucleotide polimorphism (SNP) in the group of cystic fibrosis (CF) patients has been studied. As a whole 42 CF patients and 73 persons of the control group were genotyped for IL-10 promoter-1082 G-->A SNP. The frequences of IL-10-1082 G-allele and GG high expression genotype increased significantly in CF patients in comparison to the control group. In addition, study of IL-10-1082 SNP distribution in the separate CF groups showed statistically significant increasing of the G-allele and GG-genotype frequencies in the subgroup of homozygous delF508 cariers. The possible role of IL-10 promoter SNP as a phenotype modifiers at different CF genotypes is examined.
Kashyn
O I
OI
Zastavna
D V
DV
Makykh
H V
HV
D002648:Child; D003550:Cystic Fibrosis / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
D016753:Interleukin-10