Hyperglycemia in extremely low birth weight infants in a predominantly Hispanic population and related morbidities.
OBJECTIVE
This study describes the incidence, correlates and subsequent morbidities of hyperglycemia, a highly prevalent condition in extremely low birth weight (ELBW) infants.


METHODS
A retrospective chart review of 169 infants with birth weight (BW)<1000 g was conducted. Hyperglycemia was defined as plasma glucose level > or =150 mg/dl during the first 2 weeks of life. Data were analyzed by logistic regression, multivariate analysis and Fisher exact test.


RESULTS
Overall, 88% of the study sample developed hyperglycemia in the first 2 weeks of life. Both gestational age (GA) (odds ratio (OR) 0.11, 95% confidence interval (CI)=0.01-0.89) and chorioamnionitis (OR 0.10, 95% CI=0.01-0.64) were inversely associated with hyperglycemia, whereas BW, sepsis and postnatal steroid exposure were not. After adjusting for GA, BW and postnatal steroids, hyperglycemia was associated with a statistically significant increase in retinopathy of prematurity (ROP) (OR 4.6, 95% CI 1.12-18.9). No association was found with bronchopulmonary dysplasia, intraventricular hemorrhage, death or prolonged hospital stay.


CONCLUSIONS
Lower GA was identified as the main factor associated with hyperglycemia in ELBW infants during the first 2 weeks of life. Hyperglycemia was associated with an increased incidence of ROP; further studies need to determine if this association is causal.
Blanco
C L
CL
Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. blanco@uthscsa.edu
Baillargeon
J G
JG
Morrison
R L
RL
Gong
A K
AK
D002821:Chorioamnionitis / Q000208:ethnology*; D005260:Female; D005865:Gestational Age; D005947:Glucose / Q000493:pharmacokinetics; D006630:Hispanic or Latino; D006801:Humans; D006943:Hyperglycemia / Q000208:ethnology* / Q000209:etiology; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D010288:Parenteral Nutrition / Q000706:statistics & numerical data; D011247:Pregnancy; D011379:Prognosis; D012178:Retinopathy of Prematurity / Q000209:etiology*; D012189:Retrospective Studies; D018805:Sepsis / Q000453:epidemiology
D005947:Glucose