Improved anti-inflammatory properties for naproxen with cyclodextrin-grafted polysaccharides.
Mannan and carboxymethylcellulose, previously activated by periodate oxidation, were grafted with mono-6-butylenediamino-6-deoxy-beta-cyclodextrin derivatives by reductive alkylation in the presence of sodium borohydride. The formation of supramolecular complexes between these polymers and Naproxen was confirmed by fluorescence spectroscopy. The solubility of the drug was 3.8-4.6 fold increased in the presence of the cyclodextrin-grafted polysaccharides. The in vivo anti-inflammatory property of Naproxen was 1.7 times higher after supramolecular association with beta-cyclodextrin-branched mannan.
Ramírez
Héctor L
HL
Center for Enzyme Technology, University of Matanzas, Matanzas, C.P. 44740, Cuba.
Cao
Roberto
R
Fragoso
Alex
A
Torres-Labandeira
Juan J
JJ
Dominguez
Amalia
A
Schacht
Etienne H
EH
Baños
Maysa
M
Villalonga
Reynaldo
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002351:Carrageenan / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry*; D005453:Fluorescence; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008351:Mannans / Q000737:chemistry*; D009288:Naproxen / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D008351:Mannans; D009288:Naproxen; D002351:Carrageenan; D002266:Carboxymethylcellulose Sodium