title: Cure of multiresistant Acinetobacter baumannii central nervous system infections with intraventricular or intrathecal colistin: case series and literature review.
abstract: OBJECTIVE
  CNS infections due to multiresistant Acinetobacter baumannii (MRAB) are an emerging problem in neurosurgical patients. Colistin remains one of the few remaining treatment options for MRAB but has poor CNS penetration. We describe our experience with intraventricular or intrathecal colistin for this infection.
  
  
  METHODS
  Cases known to have received intraventricular or intrathecal colistin for CNS infections due to MRAB were retrospectively reviewed regarding colistin treatment, colistin efficacy and adverse events.
  
  
  RESULTS
  Five patients were identified. All were admissions to the neurosurgical ICU and all were cured of their CNS infections. Three cases were complicated by drug-induced aseptic meningitis or ventriculitis.
  
  
  CONCLUSIONS
  This largest case series to date shows that direct instillation of colistin into the CNS may cause chemical meningitis or ventriculitis but it is an effective treatment option for MRAB CNS infection. Further study of dosing regimens is needed.
authors.affiliation: Department of Microbiology and Infectious Diseases, South Western Area Pathology Service, Liverpool, Sydney, New South Wales, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Ng
authors.forename: Iain B
authors.initials: IB
authors.lastname: Gosbell
authors.forename: John A
authors.initials: JA
authors.lastname: Kelly
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Boyle
authors.forename: John K
authors.initials: JK
authors.lastname: Ferguson
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000302:isolation & purification*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D020806:Central Nervous System Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002675:Child, Preschool; D003091:Colistin / Q000008:administration & dosage*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin