title: Thyroid involvement with Langerhans cell histiocytosis in a 3-year-old male.
abstract: We report on the thyroid involvement with Langerhans cell histiocytosis (LCH) in a 3-year-old male. The patient presented with goiter and primary hypothyroidism. His goiter caused life-threatening airway obstruction. He developed locally invasive disease 4 years after his response to LCH therapy. LCH should be suspected as a cause of goiter and thyroidectomy is recommended.
authors.affiliation: Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, New York, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Burnett
authors.forename: David
authors.initials: D
authors.lastname: Carney
authors.forename: Sanjay
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: Ernest M
authors.initials: EM
authors.lastname: Scalzetti
authors.forename: Daniel
authors.initials: D
authors.lastname: Leino
authors.forename: Abdul-Kader
authors.initials: AK
authors.lastname: Souid
mesh_terms: D000402:Airway Obstruction / Q000209:etiology; D002291:Carcinoma, Papillary / Q000150:complications; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006042:Goiter / Q000209:etiology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D013959:Thyroid Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D013964:Thyroid Neoplasms / Q000150:complications; D013965:Thyroidectomy; D013967:Thyroiditis, Autoimmune / Q000150:complications
chemical_list: D015122:Mercaptopurine; D011241:Prednisone; D008727:Methotrexate