title: A new model for low-dose food challenge in children with allergy to milk or egg.
abstract: BACKGROUND
  Atopic eczema and food allergy are common in early childhood. Children seem to gradually develop tolerance to milk and egg, and it is a relief for families when their child can tolerate small amounts of these basic foods, even if larger doses may still cause symptoms.
  
  
  OBJECTIVE
  To develop a model for low-dose oral food challenge, facilitating re-/introduction of milk or egg.
  
  
  METHODS
  In 39 children sensitized to milk and/or egg, we performed 52 challenges using a new standardized model for low-dose oral food challenge. The recipes were validated for blinding with sensorial tests.
  
  
  RESULTS
  Four children challenged to milk had a positive challenge outcome. There were no significant differences with respect to family history, associated atopic manifestations, nutritional supply, eczema severity, or skin-prick test compared with the non-reacting children, but total and specific IgE values were significantly higher. All but two of the non-reacting children were able to introduce milk and egg into their diet without problems.
  
  
  CONCLUSIONS
  We report recipes and a protocol to be used for standardized open and double-blind placebo-controlled low-dose food challenge in young children, enabling the introduction of small amounts of egg and milk into the diet during tolerance development.
authors.affiliation: Division of Paediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, and Paediatric Clinic, County Hospital Ryhov, Fonköping, Sweden. irene.devenney@lio.se
authors.forename: Irene
authors.initials: I
authors.lastname: Devenney
authors.forename: Gunilla
authors.initials: G
authors.lastname: Norrman
authors.forename: Göran
authors.initials: G
authors.lastname: Oldaeus
authors.forename: Leif
authors.initials: L
authors.lastname: Strömberg
authors.forename: Karin
authors.initials: K
authors.lastname: Fälth-Magnusson
mesh_terms: D002675:Child, Preschool; D003296:Cooking / Q000379:methods*; D004311:Double-Blind Method; D021181:Egg Hypersensitivity / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016269:Milk Hypersensitivity / Q000628:therapy*; D011446:Prospective Studies; D013649:Taste; D016896:Treatment Outcome