Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae.
Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite. Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification.
Sotelo
Jael
J
Departamento de Microbiología II. Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Rodríguez-Gabriel
Miguel A
MA
D018053:Arsenites / Q000494:pharmacology*; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D010766:Phosphorylation / Q000187:drug effects; D021381:Protein Transport / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D018053:Arsenites; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases; C015001:arsenite