title: Severe gastrointestinal involvement in paraneoplastic pemphigus.
abstract: Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease, associated with neoplasia, which has characteristic clinical, histological and immunological features. While respiratory epithelial involvement has been described in several cases, lesions in the colon epithelium have never been reported. We describe a 57-year-old Japanese woman with PNP who had many aphthae-like erosions on the colon epithelium, in addition to typical mucocutaneous PNP lesions. The intestinal erosions had histological features similar to those of PNP and linear deposition of complement, but not IgG, was observed along the colon epithelial basement membrane.
authors.affiliation: Division of Dermatology, Department of Cellular Function, Course for Molecular and Cellular Medicine, Niigata University Graduate School of Medical and Dental Sciences. 1-757 Asahimachi-dori, Niigata, 951-8510, Japan. hiromii@cameo.plala.or.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miida
authors.forename: Takashi
authors.initials: T
authors.lastname: Kazama
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Inomata
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takizawa
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Iwafuchi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ito
authors.forename: Ayako
authors.initials: A
authors.lastname: Komai
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Kyouko
authors.initials: K
authors.lastname: Togashi
mesh_terms: D003106:Colon / Q000473:pathology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D010392:Pemphigus / Q000473:pathology*; D012720:Severity of Illness Index