Hyperglycemia as an effect of cardiopulmonary bypass: intra-operative glucose management.
Cardiopulmonary bypass (CPB) is associated with surgical stress, hypothermia, hyperoxia, enhancement of neuroendocrine outflow, and administration of glucogenic catecholamines that are associated with glucogonolysis and glucogenesis that result in hyperglycemia. The hyperglycemic state during CPB has been associated with adverse outcomes, such as infection, neurological impairment, cardiac dysfunction, prolonged hospitalization, and higher mortality rates. This report justifies vigilant monitoring of blood glucose levels and a rational protocol for the treatment of hyperglycemia of all open heart surgical patients that may improve post-CPB surgical outcomes.
Najmaii
Samira
S
Sarver Heart Center and Department of Medical Pharmacology, College of Medicine, The University of Arizona, Tucson 85724, USA.
Redford
Daniel
D
Larson
Douglas F
DF
D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005947:Glucose / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000209:etiology* / Q000628:therapy; D007430:Intraoperative Care / Q000379:methods*
D005947:Glucose