The role of cyclin-dependent kinases in T-cell development, proliferation, and function.
The transit of T lymphocytes through the cell cycle in response to extracellular signals is controlled in large part by the ordered expression and degradation of cyclins and cyclin-dependent kinases and their negative regulators, the cyclin-dependent kinase inhibitors. This review outlines findings that have provided insights into how T lymphocytes integrate signals from their antigen, costimulatory, and cytokine receptors to drive cell cycle progression and discusses how the coordinated activities of these families of proteins influence multiple aspects of T-cell function, from thymic development and peripheral homeostasis to antigen-driven responses and the induction of T-cell memory and tolerance.
Rowell
Emily A
EA
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104.
Wells
Andrew D
AD
D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000502:physiology*; D016213:Cyclins / Q000502:physiology; D007108:Immune Tolerance; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000201:enzymology* / Q000276:immunology*; D013950:Thymus Gland / Q000254:growth & development / Q000276:immunology
D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D016213:Cyclins; D018844:Cyclin-Dependent Kinases