title: Fulminant hepatic failure caused by Salmonella paratyphi A infection.
abstract: We report a case of fulminant hepatic failure associated with Salmonella paratyphi A infection, in a 29-year-old patient who was admitted to the intensive care unit (ICU) with fever of two days, headache and vomiting followed by behavioural changes and disorientation. On examination, the patient appeared acutely ill, agitated, confused, and deeply jaundiced. Temperature 38.5 degrees of C, pulse 92/min, blood pressure 130/89 mmHg. Both samples of blood grew S. paratyphi A, which was sensitive to ceftriaxone and ciprofloxacin. Ceftriaxon was administered with high-dose dexamethasone. Two weeks after treatment with ceftriaxon, the patient was discharged in satisfactory condition.
authors.affiliation: Department of Medicine, Hamad General Hospital, PO Box 3050, Doha, Qatar. fakhanqal@yahoo.co.uk
authors.forename: Fahmi Yousef
authors.initials: FY
authors.lastname: Khan
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Kamha
authors.forename: Ibrahim Y
authors.initials: IY
authors.lastname: Alomary
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D017114:Liver Failure, Acute / Q000382:microbiology*; D008297:Male; D010284:Paratyphoid Fever / Q000150:complications* / Q000473:pathology*; D012482:Salmonella paratyphi A / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005938:Glucocorticoids; D002939:Ciprofloxacin; D002443:Ceftriaxone; D003907:Dexamethasone