title: Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia.
abstract: BACKGROUND
  Paraoxonase (PON) 1 is a high-density lipoprotein-associated enzyme that may protect against cardiovascular disease.
  
  
  METHODS
  We have studied the contribution of PON-1 and PON-2 single nucleotide polymorphisms (SNP; L55M, Q192R and T-107C, S311C) to the intima-media thickness of the common carotid artery in a population of children with classic familial hypercholesterolaemia.
  
  
  RESULTS
  The L-variant of the L55M SNP was associated with increased common carotid artery intima-media thickness when compared with the M-variant (P value for trend 0.03). No significant relationship was observed between the other SNP and common carotid artery intima-media thickness.
  
  
  CONCLUSIONS
  Our findings suggest that variation at the PON-1 locus contributes to early atherosclerosis in children with familial hypercholesterolaemia.
authors.affiliation: Research Laboratory of the Department of Clinical Chemistry, University Medical Center, Utrecht, The Netherlands. m.roest@azu.nl
authors.forename: Mark
authors.initials: M
authors.lastname: Roest
authors.forename: Jessica
authors.initials: J
authors.lastname: Rodenburg
authors.forename: Albert
authors.initials: A
authors.lastname: Wiegman
authors.forename: John J P
authors.initials: JJ
authors.lastname: Kastelein
authors.forename: Hieronymus A M
authors.initials: HA
authors.lastname: Voorbij
mesh_terms: D000293:Adolescent; D043303:Aryldialkylphosphatase / Q000235:genetics*; D050197:Atherosclerosis / Q000235:genetics* / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology*; D002648:Child; D005838:Genotype; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D017539:Tunica Intima / Q000473:pathology
chemical_list: D043303:Aryldialkylphosphatase