title: Lymphatic spread and microinvolvement in adenocarcinoma of the esophago-gastric junction.
abstract: BACKGROUND
  Adenocarcinoma of the esophago-gastric junction (EGJ) potentially spreads to abdominal and mediastinal lymph nodes.
  
  
  METHODS
  Eighty-five patients with type I and II EGJ cancer underwent curative esophagectomy or esophago-gastrectomy and radical abdominal and mediastinal lymphadenectomy. Microinvolvement was detected with the mAb Ber-Ep4 in all histopathologically free lymph nodes.
  
  
  RESULTS
  In type I tumors (n = 40), lower mediastinal lymph nodes were positive in 24% and among type II tumors (n = 45) in 10% of patients. Ber-Ep4+ cells in apparently free lymph nodes were found in 49% of patients. On inclusion of Ber-Ep4+ nodes, positive mediastinal lymph node staging was rising to 40 and 33% in type I and II patients, respectively. After a median observation time of 27.1 months, 37 of 85 patients (43.5%) had died of tumor disease. Kaplan-Meier analysis revealed a significant impact of nodal microinvolvement on disease-specific survival for type I and type II tumors (P = 0.016 and P < 0.001, respectively). Cox regression analysis revealed a 2.77 higher independent risk (P = 0.002) for nodal microinvolvement.
  
  
  CONCLUSIONS
  Lymphatic microinvolvement shows a high incidence in curatively resected EGJ cancer. Spread to mediastinal lymph nodes seems to necessitate lymphadenectomy of the thoracic cavity in either type.
authors.affiliation: Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Paulus G
authors.initials: PG
authors.lastname: Schurr
authors.forename: Emre F
authors.initials: EF
authors.lastname: Yekebas
authors.forename: Jussuf T
authors.initials: JT
authors.lastname: Kaifi
authors.forename: Steffi
authors.initials: S
authors.lastname: Lasch
authors.forename: Tim
authors.initials: T
authors.lastname: Strate
authors.forename: Asad
authors.initials: A
authors.lastname: Kutup
authors.forename: Guel
authors.initials: G
authors.lastname: Cataldegirmen
authors.forename: Michael
authors.initials: M
authors.lastname: Bubenheim
authors.forename: Klaus
authors.initials: K
authors.lastname: Pantel
authors.forename: Jakob R
authors.initials: JR
authors.lastname: Izbicki
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000473:pathology; D002299:Cardia; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016629:Esophagectomy; D004943:Esophagogastric Junction; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D012306:Risk; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D015996:Survival Rate