Selectively substituted thiophenes and indoles by a tandem palladium-catalyzed multicomponent reaction.
A variety of di- and trisubstituted thiophenes were synthesized by a one-pot palladium-catalyzed ortho-alkylation sequence terminated by either Heck or C-H coupling. Initial results toward the functionalization of indoles are also presented.
Mitsudo
Koichi
K
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.
Thansandote
Praew
P
Wilhelm
Thorsten
T
Mariampillai
Brian
B
Lautens
Mark
M