Autoimmune neutropenia of infancy with multiple brain abscesses during the course of human herpesvirus-6 infection.
Autoimmune neutropenia of infancy is characterized by recurrent infections such as pneumonia, otitis media, impetigo, purulent skin regions, gastritis, and upper respiratory infection. However, severe bacterial infection is uncommon. This report documents a 9-month-old boy presenting with autoimmune neutropenia in association with multiple brain abscesses during the course of human herpesvirus (HHV)-6 infection. HHV-6 has a tendency of neurovirulence, which can destroy the blood-brain barrier and facilitate the easy invasion of agents inside the brain. Although autoimmune neutropenia of infancy is benign and self limiting, it must be emphasized that severe bacterial infection will be induced by concurrent viral infection in this specific disorder.
Tokushima-Imayoshi
Miyoko
M
Department of Pediatrics, Saga University, Saga, Japan. tokushm@post.saga-med.ac.jp
Onoue
Tomoko
T
Matsuo
Muneaki
M
Yoshida
Nobuyuki
N
Sato
Takashi
T
Kobayashi
Masao
M
Hamasaki
Yuhei
Y
Ishii
Eiichi
E
D001327:Autoimmune Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D001424:Bacterial Infections / Q000150:complications; D001922:Brain Abscess / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D015654:Herpesvirus 6, Human; D006801:Humans; D007223:Infant; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D019349:Roseolovirus Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy