title: Leiomyoma characteristics and risk of subsequent surgery after myomectomy.
abstract: OBJECTIVE
  Evaluate the association between leiomyoma characteristics at myomectomy with subsequent surgery risk.
  
  
  METHODS
  A population-based nested case control study from a cohort of women at a large HMO, identified as having had a myomectomy was performed; 82 cases had subsequent uterine surgery; 82 controls, frequency matched for age and date of first surgery, did not. Medical records were abstracted; follow-up was 18-128months. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Women without subserosal myomas were more likely to have a second surgery as compared to women with at least one subserosal myoma, aOR=4.1(95% CI 1.5-10.9). Size of myomas did not predict subsequent surgery in subanalyses by type of surgery. Number of leiomyomas was not predictive of a subsequent uterine surgery overall or in subgroup analyses.
  
  
  CONCLUSIONS
  Myoma location, but not number or size, impacts the risk for subsequent leiomyoma uterine surgery.
authors.affiliation: Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98104, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Thompson
authors.forename: S D
authors.initials: SD
authors.lastname: Reed
authors.forename: B K
authors.initials: BK
authors.lastname: McCrummen
authors.forename: A K
authors.initials: AK
authors.lastname: Warolin
authors.forename: K M
authors.initials: KM
authors.lastname: Newton
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000601:surgery*; D012086:Reoperation; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000601:surgery*