Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus.
Complement activation is common in patients with systemic lupus erythematosus (SLE), resulting in hypocomplementemia and deposition of complement at sites of tissue damage. The availability of mice with specific deficiencies of components of the complement system has provided new insights into the mechanisms by which complement might be involved in autoimmunity and tissue injury in SLE. In humans, deficiencies of early components of the classical complement pathway are strongly associated with SLE. Mice lacking C1q or C4 are also predisposed to autoimmunity, which is associated with the failure of normal clearance of apoptotic cells bearing on their surfaces many of the autoantigens involved in SLE. Antiphospholipid syndrome is common in patients with SLE and studies in an animal model of fetal loss caused by antiphospholipid syndrome have shown that injury is dependent on activation of complement with subsequent neutrophil influx and synthesis of tumor necrosis factor. Insights from animal models might enable the design of more rational therapeutic approaches for manipulating the complement system in human SLE.
Cook
H Terence
HT
Department of Histopathology, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, UK. t.cook@imperial.ac.uk
Botto
Marina
M
D000818:Animals; D017209:Apoptosis; D015551:Autoimmunity / Q000502:physiology*; D003167:Complement Activation / Q000502:physiology*; D003165:Complement System Proteins / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
D003165:Complement System Proteins