Synthesis, characterization and biological activity of some platinum(II) complexes with Schiff bases derived from salicylaldehyde, 2-furaldehyde and phenylenediamine.
Four platinum(II) complexes of Schiff bases derived from salicylaldehyde and 2-furaldehyde with o- and p-phenylenediamine were reported and characterized based on their elemental analyses, IR and UV-vis spectroscopy and thermal analyses (TGA). The complexes were found to have the general formula [Pt(L)(H(2)O)(2)]Cl(2) x nH(2)O (where n=0 for complexes 1, 3, 4; n=1 for complex 2. The data obtained show that Schiff bases were interacted with Pt(II) ions in the neutral form as a bidentate ligand and the oxygens rather than the nitrogens are the most probable coordination sites. Square planar geometrical structure with two coordinated water molecules were proposed for all complexes The free ligands, and their metal complexes were screened for their antimicrobial activities against the following bacterial species: E. coli, B. subtilis, P. aereuguinosa, S. aureus; fungus A. niger, A. fluves; and the yeasts C. albican, S. cervisiea. The activity data show that the platinum(II) complexes are more potent antimicrobials than the parent Schiff base ligands against one or more microorganisms.
Gaballa
Akmal S
AS
Zagazig University, Zagazig, Egypt. akmalsg@yahoo.com
Asker
Mohsen S
MS
Barakat
Atiat S
AS
Teleb
Said M
SM
D000447:Aldehydes; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D001230:Aspergillus / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005662:Furaldehyde; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D010655:Phenylenediamines; D017671:Platinum Compounds / Q000138:chemical synthesis*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012545:Schiff Bases / Q000737:chemistry*
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D008024:Ligands; D010655:Phenylenediamines; D017671:Platinum Compounds; D012545:Schiff Bases; C013243:salicylaldehyde; D005662:Furaldehyde