title: Biosynthesis of 2-deoxystreptamine-containing antibiotics in Streptoalloteichus hindustanus JCM 3268: characterization of 2-deoxy-scyllo-inosose synthase.
abstract: A part of the new biosynthetic gene cluster for 2-deoxystreptamine-containing antibiotics was identified from Streptoalloteichus hindustanus. The alloH gene in the gene cluster was deduced to encode 2-deoxy-scyllo-inosose synthase and the expressed protein AlloH was confirmed to have this enzyme activity. Furthermore, biochemical properties of AlloH were studied.
authors.affiliation: Department of Chemistry and Materials Science, Tokyo Institute of Technology, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hirayama
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tamegai
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kudo
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Kojima
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kakinuma
authors.forename: Tadashi
authors.initials: T
authors.lastname: Eguchi
mesh_terms: D000192:Actinomycetales / Q000235:genetics / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D006595:Hexosamines / Q000096:biosynthesis; D008190:Lyases / Q000235:genetics*; D005810:Multigene Family
chemical_list: D000900:Anti-Bacterial Agents; D006595:Hexosamines; D008190:Lyases; C085631:2-deoxy-scyllo-inosose synthase; C007265:2-deoxystreptamine