Severe osteoporosis and multiple fractures in an AIDS patient treated with short-term steroids for lymphoma: a need for guidelines.
An HIV-1 infected patient on dual protease inhibitor treatment developed spontaneous vertebral fractures and avascular necrosis of the femoral bone after receiving combined chemotherapy for Burkitt's lymphoma including short-term prednisolone. The factors involved in the pathogenesis of osteopaenia and osteoporosis in this case are discussed and we propose the need for guidelines in order to reduce the incidence of such events in HIV-infected patients in the future.
Panayotakopoulos
George D
GD
Harrison Wing, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK. george.panayotakopoulos@kcl.ac.uk
Day
Sarah
S
Peters
Barry S
BS
Kulasegaram
Ranjababu
R
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000188:drug therapy* / Q000821:virology*; D050815:Fractures, Compression / Q000139:chemically induced / Q000209:etiology* / Q000821:virology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000209:etiology* / Q000821:virology; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use
D044966:Anti-Retroviral Agents; D017320:HIV Protease Inhibitors; D011239:Prednisolone