title: Infectious diseases emerging from Chinese wet-markets: zoonotic origins of severe respiratory viral infections.
abstract: OBJECTIVE
  In China, close contacts between humans and food animals have resulted in the transmission of many microbes from animals to humans. The two most notable infectious diseases in recent years are severe acute respiratory syndrome and avian influenza. In this review, these two severe zoonotic viral infections transmitted by the respiratory route, with pandemic potential, are used as models to illustrate the role of Chinese wet-markets in their emergence, amplification and dissemination.
  
  
  RESULTS
  Two research groups independently discovered the presence of severe acute respiratory syndrome coronavirus-like viruses in horseshoe bats. An astonishing diversity of coronaviruses was also discovered in different species of bats. For the recent and still ongoing avian influenza H5N1 outbreak that originated in Southeast Asia, from 2003 to 21 April 2006, 204 humans have been infected, with 113 deaths. Most patients had recent direct contacts with poultry.
  
  
  CONCLUSIONS
  In Chinese wet-markets, unique epicenters for transmission of potential viral pathogens, new genes may be acquired or existing genes modified through various mechanisms such as genetic reassortment, recombination and mutation. The wet-markets, at closer proximity to humans, with high viral burden or strains of higher transmission efficiency, facilitate transmission of the viruses to humans.
authors.affiliation: Department of Microbiology and Research Center of Infection and Immunology, Faculty of Medicine, University of Hong Kong and State Key Laboratory of Emerging Infectious Diseases, Hong Kong, PRC.
authors.forename: Patrick Cy
authors.initials: PC
authors.lastname: Woo
authors.forename: Susanna Kp
authors.initials: SK
authors.lastname: Lau
authors.forename: Kwok-yung
authors.initials: KY
authors.lastname: Yuen
mesh_terms: D000818:Animals; D002681:China; D002685:Chiroptera / Q000821:virology; D021821:Communicable Diseases, Emerging / Q000517:prevention & control / Q000635:transmission*; D017934:Coronavirus / Q000302:isolation & purification; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000302:isolation & purification; D005585:Influenza in Birds / Q000635:transmission; D007251:Influenza, Human / Q000517:prevention & control / Q000635:transmission*; D011200:Poultry / Q000821:virology; D045169:Severe Acute Respiratory Syndrome / Q000517:prevention & control / Q000635:transmission*; D015047:Zoonoses / Q000635:transmission* / Q000821:virology*