Clinical features and epileptogenesis of dysembryoplastic neuroepithelial tumor.
BACKGROUND
Dysembryoplastic neuroepithelial tumor (DNT) frequently causes medically intractable epilepsy.


OBJECTIVE
The aim of this study was to investigate the basic mechanism of epileptogenecity of the tumor.


METHODS
Clinicopathological data in 13 cases of DNT and immunohistochemical changes of ionotropic glutamate receptor subunits in the tumor and peritumoral epileptogenic cortex were studied.


CONCLUSIONS
Magnetic resonance imaging combined with electroencephalography (EEG), electrocorticography, and depth-electrode EEG was valuable to localize complicated epileptogenic zones of the patients with DNT. Neuropathological examinations of the peritumoral cerebral cortex presenting abnormal spikes showed different histopathological grades of neuronal migration disorder (NMD). The tumor cells in DNT disclosed increased immunopositivities of N-methyl-D: -aspartate receptor 1 (NR1) and NR2A/B, and peritumoral epileptogenic NMD revealed increased immunopositivities of GluR2 and GluR3. The amplification of ionotropic glutamate receptor subunits in the tumor and peritumoral NMD may be the underlying cause of epileptic seizures in DNT patients.
Lee
Min-Cheol
MC
Department of Pathology, Chonnam National University Medical School and Hospital, 5 Hakdong, Dongku, Gwangju, 501-746, South Korea. mclee@jnu.ac.kr
Kang
Jang-Young
JY
Seol
Myung-Bok
MB
Kim
Hyung-Seok
HS
Woo
Jae-Yeon
JY
Lee
Ji-Shin
JS
Jung
Shin
S
Kim
Jae-Hyoo
JH
Woo
Young-Jong
YJ
Kim
Myung-Kyu
MK
Kim
Hyung-Ihl
HI
Kim
Seung-Up
SU
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018302:Neoplasms, Neuroepithelial / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D018091:Receptors, AMPA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
C409466:NR1 NMDA receptor; C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; C104723:glutamate receptor ionotropic, AMPA 3; C104722:glutamate receptor ionotropic, AMPA 2