Improving synaptic function in a mouse model of AD.
Memory loss is an early symptom of Alzheimer's Disease (AD). The findings of Gong et al. (2006) now indicate that enhancing the activity of UCH-L1, a ubiquitin hydrolase, alleviates the synaptic dysfunction and memory loss associated with a mouse model of AD. This work also raises the question of what role UCH-L1 might play in other diseases involving protein aggregation, such as Parkinson's Disease.
Lansbury
Peter T
PT
Department of Neurology, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.
D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008569:Memory Disorders / Q000503:physiopathology*; D051379:Mice; D013569:Synapses / Q000502:physiology*; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*
C482860:UCHL1 protein, human; D043222:Ubiquitin Thiolesterase