Lineage in the vertebrate retina.
Recent results are changing the way we think about cell-fate decision mechanisms in the retina. For a long time it was accepted that lineage was not important in retinal cellular determination but, as we review here, new data show that lineage programmes might be at the heart of this process. These programmes are intrinsic, but they are also plastic and are influenced by extrinsic signals.
Cayouette
Michel
M
Cellular Neurobiology Laboratory, Institut de Recherches Cliniques de Montréal (IRCM) and Université de Montréal, Montréal, Quebec H2W 1R7, Canada. michel.cayouette@ircm.qc.ca
Poggi
Lucia
L
Harris
William A
WA
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D006801:Humans; D009024:Morphogenesis / Q000502:physiology*; D012160:Retina / Q000166:cytology* / Q000196:embryology*; D013234:Stem Cells / Q000166:cytology