In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis.
The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of Nocardia brasiliensis and Mycobacterium tuberculosis were determined. Equal MIC(50)s and MIC(90)s (0.25 and 0.5 microg/ml, respectively) were found for susceptible and multidrug-resistant isolates of M. tuberculosis. The N. brasiliensis isolates showed an MIC(90) of 1 microg/ml and an MIC(50) of 1 microg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for M. tuberculosis but fivefold-higher MICs for N. brasiliensis.
Vera-Cabrera
Lucio
L
Servicio de Dermatología, Hospital Universitario José E. González, Monterrey, N.L., México. luvera_99@yahoo.com
Gonzalez
Eva
E
Rendon
Adrian
A
Ocampo-Candiani
Jorge
J
Welsh
Oliverio
O
Velazquez-Moreno
Victor M
VM
Choi
Sung Hak
SH
Molina-Torres
Carmen
C
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D009615:Nocardia / Q000187:drug effects* / Q000302:isolation & purification; D010755:Organophosphates / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones / Q000494:pharmacology*; D011355:Prodrugs / Q000494:pharmacology*; D013777:Tetrazoles / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; C515039:DA 7157; D010755:Organophosphates; D010080:Oxazoles; D023303:Oxazolidinones; D011355:Prodrugs; D013777:Tetrazoles; C515040:tedizolid phosphate