title: Unique origin of Andaman Islanders: insight from autosomal loci.
abstract: Our mtDNA and Y chromosome studies lead to the conclusion that the Andamanese "Negrito" mtDNA lineages have survived in the Andaman Islands in complete genetic isolation from other South and Southeast Asian populations since the initial settlement of the region by the out-of-Africa migration. In order to obtain a robust reconstruction of the evolutionary history of the Andamanese, we carried out a study on the three aboriginal populations, namely, the Great Andamanese, Onge and Nicobarese, using autosomal microsatellite markers. The range of alleles (7-31.2) observed in the studied population and heterozygosity values (0.392-0.857) indicate that the selected STR markers are highly polymorphic in all the three populations, and genetic variability within the populations is significantly high, with a mean gene diversity of 77%. The Andaman "Negrito" populations do not show particular affinities either with the African populations or with the Indian populations, confirming their unique origin. In contrast, Nicobarese show close affinities with the Southeast Asian populations, suggesting their recent entry in the Islands.
authors.affiliation: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India.
authors.forename: K
authors.initials: K
authors.lastname: Thangaraj
authors.affiliation: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India.|Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, 51010, Estonia.
authors.forename: G
authors.initials: G
authors.lastname: Chaubey
authors.affiliation: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India.
authors.forename: A G
authors.initials: AG
authors.lastname: Reddy
authors.affiliation: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India.
authors.forename: V K
authors.initials: VK
authors.lastname: Singh
authors.affiliation: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India. lalji@ccmb.res.in.
authors.forename: L
authors.initials: L
authors.lastname: Singh
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D007194:India; D008297:Male; D018895:Microsatellite Repeats; D010802:Phylogeny