Effect of pyrrolidone-pyroglutamic acid composition on blood flow in rat middle cerebral artery.
We compared the effects of a pyrrolidone-pyroglutamic acid composition and nimodipine on blood circulation in the middle cerebral artery in rats. The composition produced a strong effect on blood supply to the brain, stimulated blood flow in the middle cerebral artery (by 60 +/- 9%) and decreased blood pressure (by 25.0 +/- 2.7%). The cerebrovascular effects of this composition differed from those of nimodipine. Nimodipine not only increased middle cerebral artery blood flow, but also decreased cerebral blood flow in the early period after treatment.
Semkina
G A
GA
Laboratory for Pharmacology of Cerebrovascular Disorders, VV Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Matsievskii
D D
DD
Mirzoyan
N R
NR
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004338:Drug Combinations; D008297:Male; D020768:Middle Cerebral Artery / Q000187:drug effects*; D009553:Nimodipine / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
D004338:Drug Combinations; D011760:Pyrrolidinones; D014665:Vasodilator Agents; D009553:Nimodipine; D011761:Pyrrolidonecarboxylic Acid