Regeneration via transdifferentiation: the lens and hair cells.
Tissue repair and regeneration is mediated by mainly two strategies, the one employing the services of reserve cells and the other via transdifferentiation of already differentiated somatic cells. In this mini-review some issues of transdifferentiation will be presented, especially as they pertain to regeneration and induction of lens and hair cells in several animal models.
Tsonis
Panagiotis A
PA
Department of Biology and Center for Tissue Regeneration and Engineering, University of Dayton, 300 College Park, Dayton, OH 45469-2320, USA. panagiotis.tsonis@notes.udayton.edu
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002454:Cell Differentiation; D003051:Cochlea / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D005136:Eye Proteins / Q000378:metabolism; D006198:Hair Cells, Auditory / Q000378:metabolism / Q000502:physiology*; D018398:Homeodomain Proteins / Q000378:metabolism; D007908:Lens, Crystalline / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D012038:Regeneration; D015398:Signal Transduction; D014562:Caudata; D000097607:Homeobox Protein SIX3
D019485:Bone Morphogenetic Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D000097607:Homeobox Protein SIX3