title: Antiviral activity of substituted homoisoflavonoids on enteroviruses.
abstract: The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30.
authors.affiliation: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Tait
authors.forename: Anna Laura
authors.initials: AL
authors.lastname: Salvati
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Desideri
authors.forename: Lucia
authors.initials: L
authors.lastname: Fiore
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002522:Chlorocebus aethiops; D004770:Enterovirus / Q000187:drug effects* / Q000502:physiology; D007529:Isoflavones / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D015394:Molecular Structure; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D007529:Isoflavones