C-26 and C-30 apocarotenoids from seeds of Ditaxis heterantha with antioxidant activity and protection against DNA oxidative damage.
The hexane extracts of seeds of Ditaxis heterantha afforded two new apocarotenoids whose structures corresponded to methyl 3-oxo-12'-apo-epsilon-caroten-12'-oate (1) (heteranthin) and methyl 3beta,6beta-epoxy-5beta-hydroxy-4,5-dihydro-8'-apo-epsilon-caroten-8'-oate (2) (ditaxin). Both compounds were evaluated for antioxidant activity and protection against DNA oxidative damage by using DPPH* free radical scavenging and Comet assays, respectively.
Méndez-Robles
María D
MD
Departamento de Alimentos, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala, 11340 México, DF, Mexico.
Permady
Herry H
HH
Jaramillo-Flores
María E
ME
Lugo-Cervantes
Eugenia C
EC
Cardador-Martínez
Anaberta
A
Canales-Aguirre
Alejandro A
AA
López-Dellamary
Fernando
F
Cerda-García-Rojas
Carlos M
CM
Tamariz
Joaquín
J
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds; D002338:Carotenoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004249:DNA Damage; D019665:Euphorbiaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008800:Mexico; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; C513757:ditaxin; C513756:heteranthin; D002338:Carotenoids; C004931:1,1-diphenyl-2-picrylhydrazyl