title: Evidence for stroke-induced neurogenesis in the human brain.
abstract: Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.
authors.affiliation: Buck Institute for Age Research, Novato, CA 94945, USA.
authors.forename: Kunlin
authors.initials: K
authors.lastname: Jin
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
authors.forename: Xiao Ou
authors.initials: XO
authors.lastname: Mao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Shen
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Surita
authors.initials: S
authors.lastname: Banwait
authors.forename: David A
authors.initials: DA
authors.lastname: Greenberg
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia; D002454:Cell Differentiation; D049109:Cell Proliferation; D002540:Cerebral Cortex / Q000166:cytology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000166:cytology*; D020521:Stroke / Q000473:pathology* / Q000503:physiopathology*