title: 5,8-Epidioxysterols and related derivatives from a Chinese soft coral Sinularia flexibilis.
abstract: Chromatographic separation of the methanolic extract of the marine soft coral, Sinularia flexibilis, resulted in the isolation and characterization of four new sterols, 5alpha,8alpha-epidioxygorgosta-6-en-3beta-ol (1), 5alpha,8alpha-epidioxygorgosta-6,9(11)-dien-3beta-ol (2), 22alpha,28-epidioxycholesta-5,23(E)-dien-3beta-ol (3) and its C-22 epimer (4), along with nine known sterols. The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR, MS, 1H and 13C NMR, HMQC, HMBC, and NOESY) analyses.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
authors.forename: Shanjiang
authors.initials: S
authors.lastname: Yu
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Deng
authors.forename: Leen
authors.initials: L
authors.lastname: van Ofwegen
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002681:China; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D013261:Sterols / Q000737:chemistry* / Q000378:metabolism
chemical_list: D013261:Sterols; D010100:Oxygen