title: Bilateral renal vein thrombosis in a twin newborn without known risk factors.
abstract: Neonatal renal vein thrombosis (RVT) is associated with neonatal stress, catheters and genetic prothrombotic risk factors. In an unusual case of bilateral RVT a twin newborn showed initial good adaptation at birth (weight 2,720 g). The placenta was monochorionic, diamnionic. The infant (gestational week 37) exhibited a severe macrohematuria within 24 hours after birth. Sonography of the kidneys showed a dense cortical parenchyma, loss of cortico-medullary differentiation and negative diastolic flow in both renal arteries and veins, while no thrombus in the main renal veins could be detected. No prothrombotic blood parameters and positive infection serology were detected. Because of acute renal failure peritoneal dialysis was necessary for 6 weeks. The patient was treated by heparinization for 5 days. Interestingly, it was kidney biopsy which confirmed the diagnosis of RVT in addition to the clinical presentation, whereas sonography was unspecific. Histology exhibited the picture of an ischemic contracted kidney with numerous siderophages. At present (age 19 months), the patient suffers from chronic renal failure (calculated glomerular filtration rate according to Schwartz 12 ml/min/1.73 m2). In conclusion, our case teaches that, despite the lack of a clinically obvious shock event, absence of known risk factors and indirect ultrasound findings, renal vein thrombosis should be considered in a macrohematuric newborn with renal failure. For clinical suspicion of RVT correct therapy was initiated, however, the diagnosis remained unclear until a renal biopsy was performed.
authors.affiliation: Department of Pediatrics, Medical University Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Prelog
authors.forename: H
authors.initials: H
authors.lastname: Fischer
authors.forename: I
authors.initials: I
authors.lastname: Gassner
authors.forename: A
authors.initials: A
authors.lastname: Tzankov
authors.forename: K
authors.initials: K
authors.lastname: Glatz-Krieger
authors.forename: M
authors.initials: M
authors.lastname: Mihatsch
authors.forename: L B
authors.initials: LB
authors.lastname: Zimmerhackl
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D003404:Creatinine / Q000097:blood; D004200:Diseases in Twins / Q000209:etiology*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology; D008297:Male; D012082:Renal Veins; D012307:Risk Factors; D014427:Twins; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology*
chemical_list: D003404:Creatinine