title: GnRH receptor signalling to ERK: kinetics and compartmentalization.
abstract: Many hormones, neurotransmitters and growth factors influence their target cells by activation of mitogen-activated protein kinase cascades. The consequences of such activation reflect not only the magnitude, but also the kinetics and cellular compartmentalization of kinase activity. Gonadotropin-releasing hormone (GnRH) receptors are seven-transmembrane receptors that have undergone a period of rapidly accelerated molecular evolution in which the advent of type I mammalian GnRH receptors has been associated with the loss of the carboxyl-terminal tail, a structure present in all other seven-transmembrane receptors. Here, we review spatiotemporal aspects of extracellular-signal-regulated kinase activation by gonadotropin-releasing hormone receptors, emphasizing how the absence or presence of the carboxyl-terminal tail dictates the receptors' ability to engage and signal via arrestins.
authors.affiliation: University of Bristol, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Whitson Street, Bristol BS1 3NY, UK.
authors.forename: Christopher James
authors.initials: CJ
authors.lastname: Caunt
authors.forename: Ann R
authors.initials: AR
authors.lastname: Finch
authors.forename: Kathleen R
authors.initials: KR
authors.lastname: Sedgley
authors.forename: Craig A
authors.initials: CA
authors.lastname: McArdle
mesh_terms: D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D011966:Receptors, LHRH / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D011966:Receptors, LHRH; D048049:Extracellular Signal-Regulated MAP Kinases