Immunohistochemical evaluation for hormone receptors in breast cancer: a practically useful evaluation system and handling protocol.
This article reviews the current status of hormone receptor evaluation in and out of Japan, and introduces the proposed working protocol of the task force for Adequate immunohistochemical evaluation in routine practice for breast cancer by the Japanese Breast Cancer Society. Understanding the principles and the developmental process of immunohistochemistry helps us to utilize a scoring system adequately. Methodologies of hormone receptor examination and immunohistochemical procedures are briefly introduced. Each scoring system is based on different principles. The proposed working protocol takes into account the reproducibility of results among observers, institutions and staining procedures, which is justified based on the current situation in Japan. Future directions for the standardization of immunohistochemical hormone receptor evaluation are also described.
Umemura
Shinobu
S
Department of Pathology, Tokai University School of Medicine, Japan. umemura@is.icc.u-tokai.ac.jp.
Kurosumi
Masafumi
M
Department of Pathology, Saitama Cancer Center, Japan.
Moriya
Takuya
T
Department of Pathology, Tohoku University Hospital, Japan.
Oyama
Tetsunari
T
Department of Pathology, Dokkyo University School of Medicine, Japan.
Arihiro
Kohji
K
Department of Anatomical Pathology, Hiroshima University Hospital, Japan.
Yamashita
Hiroko
H
Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Japan.
Umekita
Yoshihisa
Y
Departmeni of Pathology, Faculty of Medicine, Kagoshima University, Japan.
Komoike
Yoshifumi
Y
Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
Shimizu
Chikako
C
Department of Medical Oncology, National Cancer Center Hospital, Japan.
Fukushima
Hisaki
H
Department of Surgery, Kyorin University School of Medicine, Japan.
Kajiwara
Hiroshi
H
Department of Pathology, Tokai University School of Medicine, Japan.
Akiyama
Futoshi
F
Department of Pathology, Cancer Institute Ariake Hospital, Japan.
D001943:Breast Neoplasms / Q000378:metabolism*; D005069:Evaluation Studies as Topic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D011987:Receptors, Steroid / Q000378:metabolism*
D011987:Receptors, Steroid