The history of the paired helical filaments.
The original recognition of the paired helical filaments is discussed and amplified. The original description of what are now the neuropil threads is mentioned. The ensuing importance of both these structures is emphasised and a morphology-based hypothesis of the development of the disease from the original stimuli is offered.
Kidd
Michael
M
Department of Basic Medical Sciences, St George's, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK. mkidd@sgul.ac.uk
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D016501:Neurites / Q000378:metabolism / Q000473:pathology; D019600:Neuropil Threads / Q000235:genetics / Q000378:metabolism*