title: [Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats].
abstract: To investigate effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats.
  
  
  
  Chronic transauricular kindled seizures was induced by repeated application of initially subconvulsive electrical stimulation through ear-clip electrodes once every 24 h until the occurrence of 3 consecutive clonic-tonic seizures. A passive avoidance test was used to measure memory retention ability. Morphological changes in neurons of hippocampal CA1 region was examined after HE staining. Histamine, gamma-aminobutyric acid (GABA) and glutamate levels in the hippocampus were measured by high performance liquid chromatography (HPLC).
  
  
  
  Chronic transauricular kindled seizures impaired passive-avoidance test memory retention in rats. The damaged CA1 neurons were observed and histamine content in the hippocampus markedly decreased 24 h after the end of kindling in the chronic transauricular kindled rats.
  
  
  
  Chronic transauricular kindled seizure impaired passive-avoidance test memory retention, and it might be due to the damaged CA1 neurons and a decrease of histamine in the hippocampus induced by epilepsy.
authors.affiliation: Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310031, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Lu-ying
authors.initials: LY
authors.lastname: Liu
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Zhu
authors.forename: Wen-xia
authors.initials: WX
authors.lastname: Zhou
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006632:Histamine / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005680:gamma-Aminobutyric Acid; D006632:Histamine