title: Improved quality of life in patients with partial seizures after conversion to oxcarbazepine monotherapy.
abstract: OBJECTIVE
  Quality of life (QOL) was assessed in patients who switched to oxcarbazepine monotherapy because of the lack of efficacy or poor tolerability of their current antiepileptic drug (AED).
  
  
  METHODS
  This open-label, single-arm study consisted of patients aged 12 >or= years with partial onset seizures. Oxcarbazepine (8-10mg/kg/day for children, 600 mg/day for adults) was titrated up over 4 weeks while the existing AED was tapered off. QOL was evaluated at baseline and end of study (Week 16) using the validated-in-epilepsy QOLIE-31 questionnaire.
  
  
  RESULTS
  For all patients who completed the QOLIE-31 at baseline and completion, a statistically significant improvement was noted for both the composite and multi-item subscale QOL scores (P<0.05 vs baseline). Statistically significant mean percentage improvements of >or=10% from baseline (range=10.8-50.1%) were also noted. Significant improvements were seen in health-related QOL for patients who experienced seizure freedom or >or=50% reductions in seizure frequency with oxcarbazepine monotherapy.
  
  
  CONCLUSIONS
  Patients with partial seizures who switched to oxcarbazepine monotherapy showed statistically significant, clinically relevant improvements in QOL.
authors.affiliation: Princeton Medical Center, Princeton, NJ 08540, USA. drsachdeo@gmail.com <drsachdeo@gmail.com>
authors.forename: Rajesh C
authors.initials: RC
authors.lastname: Sachdeo
authors.forename: John R
authors.initials: JR
authors.lastname: Gates
authors.forename: Carl W
authors.initials: CW
authors.lastname: Bazil
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Barkley
authors.forename: William
authors.initials: W
authors.lastname: Tatum
authors.forename: Joseph
authors.initials: J
authors.lastname: D'Souza
authors.forename: Kevin
authors.initials: K
authors.lastname: McCague
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078330:Oxcarbazepine; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D000078330:Oxcarbazepine