Cell-adhesion inhibitors produced by a sea hare-derived Periconia sp. II. Absolute stereostructures of peribysins H and I.
Peribysins H (1) and I (2) have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using ID and 2D NMR techniques and some chemical transformations including the modified Mosher's method. These metabolites inhibited the adhesion of human-leukemia HL-60 cells to HUVEC.
Yamada
Takeshi
T
Osaka University of Pharmaceutical Sciences, Takatsuki, Japan. yamada@gly.oups.ac.jp
Minoura
Katsuhiko
K
Tanaka
Reiko
R
Numata
Atsushi
A
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001048:Aplysia / Q000382:microbiology*; D016227:Benzoquinones / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects*; D042783:Endothelial Cells / Q000187:drug effects; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D047029:Lactams, Macrocyclic / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000378:metabolism*; D009284:Naphthols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017828:Rifabutin / Q000031:analogs & derivatives
D000903:Antibiotics, Antineoplastic; D016227:Benzoquinones; D005663:Furans; D047029:Lactams, Macrocyclic; D009284:Naphthols; C513063:peribysin H; C513062:peribysin I; D017828:Rifabutin; C020754:herbimycin