title: Genetic characterization of influenza A viruses (H5N1) isolated from 3rd wave of Thailand AI outbreaks.
abstract: Three major outbreaks of avian influenza (AI) occurred in Thailand. During the third episode in October 2005, we have isolated H5N1 viruses from one human case and three poultry cases. The whole genomes of AI viruses from human, chickens and quail from the outbreaks were characterized. Sequence analysis of eight gene segments revealed that the 2005 H5N1 viruses isolated in October 2005 were closely related to those recovered from chicken, tiger(s) and human(s) in January and July 2004. In addition, the genetic changes of the AI isolates at the HA cleavage site have been observed.
authors.affiliation: Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
authors.forename: Alongkorn
authors.initials: A
authors.lastname: Amonsin
authors.forename: Salin
authors.initials: S
authors.lastname: Chutinimitkul
authors.forename: Nuananong
authors.initials: N
authors.lastname: Pariyothorn
authors.forename: Thaweesak
authors.initials: T
authors.lastname: Songserm
authors.forename: Sudarat
authors.initials: S
authors.lastname: Damrongwantanapokin
authors.forename: Suphasawatt
authors.initials: S
authors.lastname: Puranaveja
authors.forename: Rungroj
authors.initials: R
authors.lastname: Jam-On
authors.forename: Namdee
authors.initials: N
authors.lastname: Sae-Heng
authors.forename: Sunchai
authors.initials: S
authors.lastname: Payungporn
authors.forename: Apiradee
authors.initials: A
authors.lastname: Theamboonlers
authors.forename: Arunee
authors.initials: A
authors.lastname: Chaisingh
authors.forename: Rachod
authors.initials: R
authors.lastname: Tantilertcharoen
authors.forename: Sanipa
authors.initials: S
authors.lastname: Suradhat
authors.forename: Roongroje
authors.initials: R
authors.lastname: Thanawongnuwech
authors.forename: Yong
authors.initials: Y
authors.lastname: Poovorawan
mesh_terms: D000818:Animals; D004196:Disease Outbreaks / Q000662:veterinary; D016679:Genome, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics* / Q000302:isolation & purification*; D005585:Influenza in Birds / Q000453:epidemiology / Q000821:virology*; D007251:Influenza, Human / Q000821:virology*; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D011200:Poultry / Q000821:virology; D011784:Quail / Q000821:virology; D017385:Sequence Homology; D013785:Thailand / Q000453:epidemiology; D046010:Tigers / Q000821:virology
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; C109963:hemagglutinin, avian influenza A virus