[Incomplete protective effects of minocycline on traumatic brain injury in rats and mice].
To evaluate protective effect of minocycline,a semisynthetic tetracycline derivative on different traumatic brain injuries in rats and mice.



The opened brain trauma was induced in rats and the closed head injury and cold brain injury were induced in mice. In 3 brain trauma models, minocycline (45 mg/kg, ip) was administered twice daily for 2 d before the operation, at 30 min before and 1 h after the operation, and once daily for 2 d following the operation (totally 8 doses in 5 d). After the operation, the behavioral alteration was observed daily, lesion area and survival neuron density were measured at the end of the experiments (14 d after the injuries).



For rat opened traumatic injury, minocycline promoted the recovery of hindlimb motor activity (inclined board angle), but did not alter other indexes. For mouse closed head traumatic injury, minocycline reduced the neuron loss, but did not improve behavioral dysfunction. For mouse cold injury-induced trauma, minocycline reduced death rate and lesion area, but did not remarkably improve behavior and neuron loss.



Minocycline only has an incomplete neuroprotective effect on different brain traumatic injuries in rats and mice.
Sheng
Wen-wen
WW
Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310031, China.
Zhang
Wei-ping
WP
Wang
Meng-ling
ML
Zhang
Shi-hong
SH
Hu
Hua
H
Chu
Sheng-li
SL
Zhou
Yu
Y
Fang
San-hua
SH
Yu
Guo-liang
GL
Qian
Xiao-dong
XD
Chen
Ke-da
KD
Xu
Hui-min
HM
Liu
Lu-ying
LY
Zhang
Lei
L
Wei
Er-qing
EQ
D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008911:Minocycline / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018696:Neuroprotective Agents; D008911:Minocycline