Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancer.
OBJECTIVE
E-cadherin plays a role in carcinogenesis. For two genetic polymorphisms in the gene (CDH1) promoter, a reduced transcription has been reported: a C/A single nucleotide polymorphism (SNP) and a G/GA SNP at -160 bp and -347 bp, respectively, upstream of the transcriptional start site. We studied the association between both polymorphisms and the risk of bladder cancer.


METHODS
One hundred and ninety-seven patients with bladder cancer and 344 population controls were genotyped and haplotyped for both SNPs.


RESULTS
A borderline significantly increased risk for bladder cancer was found for A allele carriers (OR 1.36; 95% CI: 0.96-1.94). We did not find any association between the -347 G/GA SNP and bladder cancer. Haplotype analyses did not yield much stronger associations with bladder cancer than the -160 C/A genotype analyses.


CONCLUSIONS
This study supports earlier suggestions that the -160 C/A SNP in the CDH1 promoter is a risk factor for bladder cancer.
Kiemeney
Lambertus A
LA
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
van Houwelingen
Kjeld P
KP
Bogaerts
Manon
M
Witjes
J Alfred
JA
Swinkels
Dorine W
DW
den Heijer
Martin
M
Franke
Barbara
B
Schalken
Jack A
JA
Verhaegh
Gerald W
GW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D015820:Cadherins