Circadian variation in mouse hippocampal cell proliferation.
Hippocampal cell proliferation and concomitant motor activity were examined in adult male mice (C57BL/6J) across a 12:12h light-dark cycle. 5-Bromo-2'-deoxyuridine (BrdU) (200 mg/kg, i.p.) was administered at six equally spaced time points across 24h. A significant change in cell proliferation was found in the hilus (light phase>dark phase), but not in the granule cell layer (GCL)/subgranular zone (SGZ). Since it is generally believed that proliferating cells in the hilus and GCL/SGZ give rise primarily to glia and neurons, respectively, these data suggest a possible circadian influence on gliogenesis, rather than neurogenesis.
Kochman
Linda J
LJ
Program in Neuroscience, Princeton University, Princeton, NJ 08540-1010, USA. lkochman@Princeton.edu
Weber
E Todd
ET
Fornal
Casimir A
CA
Jacobs
Barry L
BL
D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D049109:Cell Proliferation; D002940:Circadian Rhythm / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
D001973:Bromodeoxyuridine