title: Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists.
abstract: The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in vitro and to block FITC-Fg binding to alpha(IIb)beta(3) on washed human platelets.
authors.affiliation: Department of Medicinal Chemistry, A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, 86 Lustdorfskaya doroga, 65080 Odessa, Ukraine.
authors.forename: Olga L
authors.initials: OL
authors.lastname: Malovichko
authors.forename: Anna S
authors.initials: AS
authors.lastname: Petrus
authors.forename: Andrei A
authors.initials: AA
authors.lastname: Krysko
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Kabanova
authors.forename: Sergei A
authors.initials: SA
authors.lastname: Andronati
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Karaseva
authors.forename: Anna V
authors.initials: AV
authors.lastname: Kiriyak
mesh_terms: D001667:Binding, Competitive / Q000187:drug effects; D001681:Biological Assay; D004353:Drug Evaluation, Preclinical; D006801:Humans; D018716:Molecular Mimicry; D015394:Molecular Structure; D010795:Phthalic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000187:drug effects; D011485:Protein Binding / Q000187:drug effects; D039341:Receptors, Fibrinogen / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D010795:Phthalic Acids; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D039341:Receptors, Fibrinogen; C059768:isophthalate