Molecular characterization of resistance to macrolides in Bartonella henselae.
We selected in vitro erythromycin-resistant strains of Bartonella henselae. The mutants obtained had point mutations in domain V of 23S rRNA and/or in ribosomal protein L4. One lymph node of a patient with cat-scratch disease had such a mutation in 23S rRNA, suggesting that natural resistant strains may infect humans.
Biswas
Silpak
S
Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine et de Pharmacie, Université de la Méditerranée, 13385 Marseille Cedex 05, France.
Raoult
Didier
D
Rolain
Jean-Marc
JM
D018416:Bartonella henselae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D002372:Cat-Scratch Disease / Q000382:microbiology; D002648:Child; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D017354:Point Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics
D018942:Macrolides; D012338:RNA, Ribosomal, 23S; D004917:Erythromycin