Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells in vitro and in vivo.
Comparative analysis of differentiation of human neural and mesenchymal stem cells in tissue culture and after transplantation into the brain was carried out using the same antibody set. Neural stem cells differentiated into all types of neural cells, are retained after transplantation, migrate, and form reciprocal relationships with the recipient brain. Mesenchymal stem cells were incapable of neural development under conditions of common culturing or after transplantation and retained the fibroblast-like status. Recipient filaments grew into mesenchymal stem cell transplants containing no neural cells due to local changes in the extracellular matrix at the site of transplantation.
Aleksandrova
M A
MA
Institute of Developmental Biology, Russian Academy of Sciences. aleksandrova@vigg.ru
Sukhikh
G T
GT
Chailakhyan
R K
RK
Podgornyi
O V
OV
Marei
M V
MV
Poltavtseva
R A
RA
Gerasimov
Yu V
YV
D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D002478:Cells, Cultured; D049452:Green Fluorescent Proteins / Q000032:analysis; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000737:chemistry / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000737:chemistry / Q000166:cytology* / Q000637:transplantation; D011817:Rabbits; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology* / Q000502:physiology; D014746:Vimentin / Q000032:analysis
D014746:Vimentin; D049452:Green Fluorescent Proteins