title: Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimesterof pregnancy?
abstract: Untreated asymptomatic bacteriuria has been associated with acute pyelonephritis, which may have a role in many maternal and fetal complications. Acute pyelonephritis in pregnancy is related to anemia, septicemia, transient renal dysfunction, and pulmonary insufficiency. A randomized study was conducted to assess the clinical and microbiological efficacy of a single dose of fosfomycin trometamol for the treatment of asymptomatic bacteriuria in the second trimester of pregnancy compared with a 5-day regimen of cefuroxime axetyl. Forty-four women received fosfomycin trometamol and 40 women received cefuroxime axetyl. There were no statistically significant differences between both groups regarding the mean age and mean duration of pregnancy. Therapeutic success was achieved in 93.2% of the patients treated with fosfomycin trometamol vs 95% of those treated with cefuroxime axetyl. A single dose of fosfomycin trometamol is a safe and effective alternative in the treatment of asymptomatic urinary tract infections in the second trimester of pregnancy.
authors.affiliation: Department of Urology, Fatih University School of Medicine, Alpaslan Türkeş cad., 06510 Emek, Ankara, Turkey. omerbayrak69@yahoo.com
authors.forename: Omer
authors.initials: O
authors.lastname: Bayrak
authors.forename: Ersin
authors.initials: E
authors.lastname: Cimentepe
authors.forename: Ilknur
authors.initials: I
authors.lastname: Inegöl
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Atmaca
authors.forename: Candan Iltemir
authors.initials: CI
authors.lastname: Duvan
authors.forename: Akif
authors.initials: A
authors.lastname: Koç
authors.forename: Nilgün Oztürk
authors.initials: NO
authors.lastname: Turhan
mesh_terms: D000328:Adult; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001437:Bacteriuria / Q000188:drug therapy*; D002444:Cefuroxime / Q000008:administration & dosage / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011262:Pregnancy Trimester, Second; D012449:Safety; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D002444:Cefuroxime; C040738:cefuroxime axetil