title: Generating short peptidic ligands for silver nanowires from phage display random libraries.
abstract: We report the generation of peptide ligands for silver nanowires using a linear 12-mer peptide phage display random library technique. Phage clones that specifically bind the silver nanowires are sequenced after three rounds of biopanning, and obtained DNA sequences suggest that there are a few conserved amino acid residues which may be critical for binding. A selected binding peptide, together with two mutant peptide sequences, were subsequently synthesized on Tentagel resins to examine the importance of both the identities and positions of the conserved amino acid residues.
authors.affiliation: Department of Chemistry and Materials Science, Biosecurity and Nanosciences Laboratory, Lawrence Livermore National Laboratory, University of California, Livermore, CA 94551, USA.
authors.forename: Priscilla
authors.initials: P
authors.lastname: Chan
authors.forename: Tiffany
authors.initials: T
authors.lastname: Phan
authors.forename: Michael C
authors.initials: MC
authors.lastname: Kao
authors.forename: Cheryl
authors.initials: C
authors.lastname: Dolan
authors.forename: Jeffrey B-H
authors.initials: JB
authors.lastname: Tok
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D008024:Ligands; D043942:Nanotubes / Q000737:chemistry*; D010316:Particle Size; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D019151:Peptide Library; D010455:Peptides; D012834:Silver