Dead-box proteins: a family affair--active and passive players in RNP-remodeling.
DEAD-box proteins are characterized by nine conserved motifs. According to these criteria, several hundreds of these proteins can be identified in databases. Many different DEAD-box proteins can be found in eukaryotes, whereas prokaryotes have small numbers of different DEAD-box proteins. DEAD-box proteins play important roles in RNA metabolism, and they are very specific and cannot mutually be replaced. In vitro, many DEAD-box proteins have been shown to have RNA-dependent ATPase and ATP-dependent RNA helicase activities. From the genetic and biochemical data obtained mainly in yeast, it has become clear that these proteins play important roles in remodeling RNP complexes in a temporally controlled fashion. Here, I shall give a general overview of the DEAD-box protein family.
Linder
Patrick
P
Department of Microbiology and Molecular Medicine, CMU 1, rue Michel Servet, CH-1211 Genève 4, Switzerland. patrick.linder@medecine.unige.ch
D020816:Amino Acid Motifs; D017124:Conserved Sequence; D053487:DEAD-box RNA Helicases; D006801:Humans; D020365:RNA Helicases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D012316:RNA Nucleotidyltransferases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D012261:Ribonucleoproteins / Q000737:chemistry* / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D012261:Ribonucleoproteins; D029701:Saccharomyces cerevisiae Proteins; D012316:RNA Nucleotidyltransferases; C498288:DDX4 protein, human; C106767:HCA4 protein, S cerevisiae; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases