title: Impact of a targeted hepatitis B vaccination program in Amsterdam, The Netherlands.
abstract: To evaluate hepatitis B virus (HBV) risk group vaccination in Amsterdam, which started in 1998, we examined 342 reported acute HBV-cases and sequenced 85 DNA isolates. The reported number of cases declined from 214 in 1992-1997 to 128 in 1998-2003, due to a decline in injecting drug users (IDU) and their heterosexual partners. Phylogenetic analyses showed that after 1998, the IDU cluster nearly disappeared, probably due to a decline in injecting. Acute HBV remained stable among men having sex with men; given their increased sexual risk behavior, vaccination has probably prevented an increase in their acute infections. Currently, 48-72% of the people who should be included in the program are still susceptible to HBV.
authors.affiliation: GGD, Public Health Service, Department of Infectious Diseases, Amsterdam, The Netherlands. rvhoudt@ggd.amsterdam.nl
authors.forename: Robin
authors.initials: R
authors.lastname: van Houdt
authors.forename: Gerard J B
authors.initials: GJ
authors.lastname: Sonder
authors.forename: Nicole H T M
authors.initials: NH
authors.lastname: Dukers
authors.forename: Lian P M J
authors.initials: LP
authors.lastname: Bovee
authors.forename: Anneke
authors.initials: A
authors.lastname: van den Hoek
authors.forename: Roel A
authors.initials: RA
authors.lastname: Coutinho
authors.forename: Sylvia M
authors.initials: SM
authors.lastname: Bruisten
mesh_terms: D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology / Q000209:etiology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010802:Phylogeny; D012189:Retrospective Studies; D015819:Substance Abuse, Intravenous / Q000150:complications; D014611:Vaccination
chemical_list: D017325:Hepatitis B Vaccines