Ex vivo/in vitro absorption of STW 5 (Iberogast) and its extract components.
To correlate the pharmacological effects of the fixed herbal combination STW 5 (Iberogast) containing nine extract components with its confirmed clinical efficacy, ex vivo/in vitro absorption tests were performed. For the investigation, the everted gut sac technique and, in a pilot study, the Caco-2-cell model were used. The absorption rate of the extracts was determined by measuring characteristic marker substances of each of the individual extracts using HPLC or GC techniques. The results allow us to conclude that the investigated substances from STW 5 possess a good bioavailability, which is in accordance with the rapid onset of the therapeutic efficacy and explains its known pharmacological effects and clinical efficacy in terms of multiple drug action and multi-target therapy, respectively.
Kelber
O
O
Scientific Department, Steigerwald Arzneimittelwerk GmbH, Havelstrasse 5, D-64295 Darmstadt, Germany. kelber@steigerwald.de
Wittwer
A
A
Lapke
C
C
Kroll
U
U
Weiser
D
D
Okpanyi
S N
SN
Heilmann
J
J
D000818:Animals; D018938:Caco-2 Cells; D005765:Gastrointestinal Agents / Q000493:pharmacokinetics*; D006801:Humans; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D010865:Pilot Projects; D010936:Plant Extracts / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D005765:Gastrointestinal Agents; D010936:Plant Extracts; C039964:iberogast