title: BLyS and B cell homeostasis.
abstract: Naïve peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.
authors.affiliation: Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA. Robert.Woodland@umassmed.edu
authors.forename: Robert T
authors.initials: RT
authors.lastname: Woodland
authors.forename: Madelyn R
authors.initials: MR
authors.lastname: Schmidt
authors.forename: Craig B
authors.initials: CB
authors.lastname: Thompson
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D017209:Apoptosis; D053264:B-Cell Activating Factor / Q000276:immunology / Q000502:physiology*; D053265:B-Cell Activation Factor Receptor / Q000276:immunology / Q000502:physiology*; D053301:B-Cell Maturation Antigen / Q000276:immunology / Q000502:physiology; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D002470:Cell Survival; D006706:Homeostasis; D006801:Humans; D017578:Immunoglobulin Class Switching; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology; D051379:Mice; D008805:Mice, Inbred A; D018448:Models, Immunological; D009363:Neoplasm Proteins / Q000276:immunology / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D014162:Transfection; D053303:Transmembrane Activator and CAML Interactor Protein / Q000276:immunology / Q000502:physiology; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000276:immunology* / Q000502:physiology
chemical_list: D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor; D053301:B-Cell Maturation Antigen; D009363:Neoplasm Proteins; D011993:Recombinant Fusion Proteins; C108467:TNFRSF13B protein, human; C435926:TNFRSF13C protein, human; C086966:TNFRSF17 protein, human; C114631:TNFSF13 protein, human; C505719:TNFSF13B protein, human; C486361:Tnfrsf13b protein, mouse; C486662:Tnfrsf13c protein, mouse; C490176:Tnfrsf17 protein, mouse; C491959:Tnfsf13 protein, mouse; C505720:Tnfsf13b protein, mouse; D014157:Transcription Factors; D053303:Transmembrane Activator and CAML Interactor Protein; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D011494:Protein Kinases