title: Aerosol measles vaccination in macaques: preclinical studies of immune responses and safety.
abstract: The comparative efficacy and safety of measles vaccination via the aerosol route versus subcutaneous injection has not been fully resolved. We vaccinated cynomolgus monkeys (Macaca fascicularis) with the live-attenuated Edmonston-Zagreb measles virus (MV) vaccine and compared different routes of administration in the immunocompetent and the immunocompromised host. Immunogenicity and protective efficacy of aerosol vaccination using devices similar to those previously used in humans were comparable to those in animals vaccinated by injection. No evidence for a safety hazard associated with the route of vaccination was detected. The results of this study support further clinical evaluation of aerosol vaccination for measles.
authors.affiliation: Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. r.deswart@erasmusmc.nl
authors.forename: Rik L
authors.initials: RL
authors.lastname: de Swart
authors.forename: Thijs
authors.initials: T
authors.lastname: Kuiken
authors.forename: Jorge
authors.initials: J
authors.lastname: Fernandez-de Castro
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Papania
authors.forename: John V
authors.initials: JV
authors.lastname: Bennett
authors.forename: José L
authors.initials: JL
authors.lastname: Valdespino
authors.forename: Phil
authors.initials: P
authors.lastname: Minor
authors.forename: Clyde L
authors.initials: CL
authors.lastname: Witham
authors.forename: Selma
authors.initials: S
authors.lastname: Yüksel
authors.forename: Helma
authors.initials: H
authors.lastname: Vos
authors.forename: Geert
authors.initials: G
authors.lastname: van Amerongen
authors.forename: Albert D M E
authors.initials: AD
authors.lastname: Osterhaus
mesh_terms: D000336:Aerosols / Q000008:administration & dosage; D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D016867:Immunocompromised Host / Q000276:immunology; D008251:Macaca; D008297:Male; D008457:Measles / Q000276:immunology / Q000821:virology; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D008459:Measles virus / Q000502:physiology; D014779:Virus Replication
chemical_list: D000336:Aerosols; D008458:Measles Vaccine