title: [Microbial inhibitors of lysozyme].
abstract: Lysozyme is one of the most important factors of innate immunity, possessing anti-microbial action against a wide range of microorganisms due to cationic nature of protein and, in a lesser degree, due to muramidase activity. In the process of evolution, different mechanisms of lysozyme inhibition, defined as anti-lysozyme activity (ALA), were formed in microorganisms. The usage of the delayed antagonism principle allowed to reveal anti-lysozyme sign in microorganisms of different phylogenetic groups. In the review, data on the occurrence and level of anti-lysozyme activity in pathogens and representatives of normal microflora were presented; findings on nature and genetic determinants of lysozyme inhibitors are given. questions on drug regulation of ALA of the causative agents in infectious diseases and dysbiotic conditions are discussed.
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
authors.forename: A V
authors.initials: AV
authors.lastname: Valyshev
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D001424:Bacterial Infections / Q000276:immunology; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D001431:Bacteriological Techniques; D005075:Biological Evolution; D003470:Culture Media; D023082:Defensins / Q000737:chemistry / Q000378:metabolism; D005658:Fungi / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007113:Immunity, Innate; D009113:Muramidase / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D019936:Probiotics / Q000494:pharmacology; D013696:Temperature
chemical_list: D001426:Bacterial Proteins; D003470:Culture Media; D023082:Defensins; D009113:Muramidase