Sleep and temperature responses of inbred mice with Candida albicans-induced pyelonephritis.
Human patients with renal disease frequently develop disturbed sleep and severe fatigue. To develop a model for studying factors that contribute to these symptoms, we characterized the sleep patterns of various strains of mice after acute challenge with the fungal organism Candida albicans. After intravenous administration to mice, C. albicans typically colonizes the kidney, producing acute pyelonephritis. Various strains of inbred mice demonstrate marked variation in the temperature and sleep responses that develop after challenge, with individual strains generally showing increased or reduced somnolence in association with fever or hypothermia, respectively. C. albicans-infected mice may be a useful model for identifying the genes and mechanisms that link sleep, temperature, fatigue, and the immune response.
Toth
Linda A
LA
Southern Illinois University School of Medicine, Springfield, Illinois, USA. ltoth@siumed.edu
Hughes
Larry F
LF
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000503:physiopathology*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011704:Pyelonephritis / Q000382:microbiology* / Q000503:physiopathology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*; D013045:Species Specificity