title: Severe muscular weakness: an unusual adverse effect of azathioprine therapy.
abstract: Azathioprine, an analog of 6-mercaptopurine has been used as a steroid-sparing agent in the treatment of inflammatory bowel disease for over 30 years. Hypersensitivity reactions to azathioprine including fever, myalgia, arthralgia, rash are well documented in the literature. Here, we report 2 cases of azathioprine hypersensitivity in patients with inflammatory bowel disease manifesting with the unusual symptom of profound muscular weakness resulting in inability to perform simple tasks such as lifting even light objects, sitting upright, and walking a few steps. Development of severe weakness raised concern about myositis, rhabdomyolysis, myopathy, and sepsis in these patients. Discontinuation of azathioprine resulted in prompt improvement of muscular weakness, and rechallenge led to recurrence of similar symptoms within hours. These observations suggest that the development of muscular weakness in patients on azathioprine should be considered as an adverse effect of the drug. Failure to recognize this adverse outcome can lead to prolonged periods of muscular weakness in this group of patients.
authors.affiliation: Department of Medicine, Division of Gastroenterology, Sinai Hospital of Baltimore, MD, USA. akarhadkar@gmail.com
authors.forename: Arati S
authors.initials: AS
authors.lastname: Karhadkar
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Schwartz
authors.forename: Manish
authors.initials: M
authors.lastname: Arora
authors.forename: Sudhir K
authors.initials: SK
authors.lastname: Dutta
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine