[The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome].
The treatment of Tourette's syndrome is a challenge. Dopamine receptor antagonists are the drugs of first choice for the treatment of tics. Because large controlled trials are lacking, there is no consensus about which of the different neuroleptic drugs should be preferred. In Germany, tiapride seems to be used most often for the treatment of tics in children - although only one small controlled trial has been performed on it till now. In adults, other dopamine receptor antagonists such as risperidone, pimozide, and sulpiride seem to be more effective than tiapride. Today it is unknown whether new atypical neuroleptic drugs including the benzamide amisulpride are more effective than the older benzamides tiapride and sulpiride.
Müller-Vahl
K R
KR
Abteilung für Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Carl-Neuberg-Stasse 1, 30625 Hannover. mueller-vahl.kirsten@mh-hannover.de
D000077582:Amisulpride; D018726:Anti-Dyskinesia Agents / Q000008:administration & dosage / Q000009:adverse effects; D001549:Benzamides / Q000008:administration & dosage / Q000009:adverse effects; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D005858:Germany; D006801:Humans; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000639:trends; D013469:Sulpiride / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D013976:Tiapamil Hydrochloride / Q000008:administration & dosage* / Q000009:adverse effects; D005879:Tourette Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome
D018726:Anti-Dyskinesia Agents; D001549:Benzamides; D018492:Dopamine Antagonists; D013469:Sulpiride; D000077582:Amisulpride; D013976:Tiapamil Hydrochloride