title: Prior antibacterial peptide-mediated inhibition of protein folding in bacteria mutes resistance enzymes.
abstract: The antimicrobial activity of amoxicillin against TEM-1-expressing strains could be fully recovered when bacteria were preincubated with sublethal doses of an antibacterial peptide derivative. Assays with the simultaneous administration of antibiotics or synergy assays with kanamycin or ciprofloxacin, where resistance development does not involve properly folded proteins, failed to yield similar results.
authors.affiliation: Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA. otvos@temple.edu
authors.forename: Laszlo
authors.initials: L
authors.lastname: Otvos
authors.forename: Vanessa
authors.initials: V
authors.lastname: de Olivier Inacio
authors.forename: John D
authors.initials: JD
authors.lastname: Wade
authors.forename: Predrag
authors.initials: P
authors.lastname: Cudic
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D019476:Insect Proteins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D017510:Protein Folding; D001618:beta-Lactamases / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D029968:Escherichia coli Proteins; D019476:Insect Proteins; C087710:pyrrhocoricin protein, Pyrrhocoris apterus; D000658:Amoxicillin; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1