The control of histone lysine methylation in epigenetic regulation.
Histone lysine methylation plays a fundamental role in chromatin organization and function. This epigenetic mark is involved in many biological processes such as heterochromatin formation, chromosome X inactivation, genomic imprinting and transcriptional regulation. Here, we review recent advances in how histone lysine methylation participates in these biological events, and the enzymes that control histone lysine methylation and demethylation.
Völkel
Pamela
P
Institut de Recherche Interdisciplinaire, CNRS FRE 2963, IRI @ Institut de Biologie de Lille, 1, rue du Pr. Calmette, F-59021 Lille Cedex, France.
Angrand
Pierre-Olivier
PO
D000818:Animals; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D008745:Methylation; D008780:Methyltransferases / Q000737:chemistry / Q000502:physiology*; D008957:Models, Genetic; D014158:Transcription, Genetic
D006657:Histones; D008780:Methyltransferases; D008239:Lysine