Immunological and virological aspects of autologous stem cell transplantation in HIV+ patients.
Autologous stem cell transplantation (ASCT) is an effective therapeutic option in patients with human immunodeficiency virus-associated lymphomas (HIV-L). This review will focus on the experimental and clinical data regarding the effects of ASCT on the reconstitution of lymphocyte subsets, T-cell repertoire and thymic function in HIV-L patients. Current data on the kinetics of reactivation of HIV, Epstein-Barr virus, cytomegalovirus and hepatitis C virus during mobilization and after reinfusion of stem cells will be also analyzed.
De Paoli
Paolo
P
Department of Microbiology, Immunology and Virology, Centro di Riferimento Oncologico, IRCCS, 33081 Aviano (PN), Italy. pdepaoli@cro.it
D006678:HIV; D015658:HIV Infections / Q000276:immunology / Q000628:therapy* / Q000821:virology; D006801:Humans; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous