title: Remodeling of vaginal connective tissue in patients with prolapse.
abstract: OBJECTIVE
  Pelvic organ prolapse is a common disease that negatively affects the lives of women. To date, basic science research into the pathogenesis of prolapse has been limited. The vagina and its supportive connective tissues provide one of the primary mechanisms of support to the pelvic organs. This review summarizes our current understanding of the alterations in these tissues in women with prolapse.
  
  
  RESULTS
  Current research suggests that the vagina and its supportive tissues actively remodel in response to different environmental stimuli. The literature has many shortcomings due to restricted access to tissue, absence of longitudinal data, and limited animal models. Nevertheless, recent studies indicate that within prolapsed tissue metabolism of collagen and elastin is altered. Thus, not only the synthesis of those structural proteins but also the balance between the activity of the major proteolytic enzymes that degrade them and the inhibitors of proteolysis are important components to consider in studies on the pathogenesis of pelvic organ prolapse.
  
  
  CONCLUSIONS
  Biochemical studies of the vagina and its supportive connective tissues have improved understanding of the contribution of altered connective tissue to the pathogenesis of prolapse. It is important to continue research in this area, as the knowledge gained from these studies will allow for the development of innovative reconstructive procedures and the establishment of preventive measures.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecological Specialties, Magee-Women's Hospital and Magee Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Marianna
authors.initials: M
authors.lastname: Alperin
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Moalli
mesh_terms: D003238:Connective Tissue / Q000378:metabolism; D005260:Female; D024022:Fibrillar Collagens / Q000378:metabolism; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism; D010388:Pelvis / Q000473:pathology*; D016896:Treatment Outcome; D014596:Uterine Prolapse / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
chemical_list: D024022:Fibrillar Collagens; D008666:Metalloendopeptidases