title: [In vitro study of platelet glycoprotein monoclonal antibody eluting stents].
abstract: In order to prove the feasibility of preparation of the drug-incorporated stent by immersing stent wires in the monoclonal antibody (mAb) solution, fluorescence stain and image analysis were used to evaluate the L-PLA-coated stent. Absorption was measured using a radioisotope technique after preparing the mAb-incorporated stent, and the absorption curve was determined from the absorption data. In an in vitro perfusion circuit, the antibody was eluted from the stent matrices, and the related influence factors were evaluated based on the release data.
authors.affiliation: Bioengineering College of Chongqing University.
authors.forename: Lai-long
authors.initials: LL
authors.lastname: Luo
authors.forename: Gui-xue
authors.initials: GX
authors.lastname: Wang
authors.forename: Tie-ying
authors.initials: TY
authors.lastname: Yin
authors.forename: Shi-sui
authors.initials: SS
authors.lastname: Luo
authors.forename: Chang-gen
authors.initials: CG
authors.lastname: Ruan
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Hou
mesh_terms: D000042:Absorption; D000497:Alloys / Q000737:chemistry; D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000276:immunology; D054855:Drug-Eluting Stents; D006083:Graft Occlusion, Vascular / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000276:immunology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D011108:Polymers / Q000032:analysis / Q000737:chemistry; D013997:Time Factors
chemical_list: D000497:Alloys; D000911:Antibodies, Monoclonal; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011108:Polymers; D019344:Lactic Acid