Topoisomerase II checkpoints: universal mechanisms that regulate mitosis.
Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.
Clarke
Duncan J
DJ
Department of Genetics, Cell Biology & Development, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. Duncan.J.Clarke-2@umn.edu
Vas
Amit C
AC
Andrews
Catherine A
CA
Díaz-Martínez
Laura A
LA
Giménez-Abián
Juan F
JF
D002877:Chromosomes, Human / Q000648:ultrastructure; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D054659:Diketopiperazines; D004791:Enzyme Inhibitors / Q000494:pharmacology; D017353:Gene Deletion; D006801:Humans; D008938:Mitosis; D009363:Neoplasm Proteins / Q000235:genetics; D010879:Piperazines / Q000494:pharmacology; D064249:Securin; D059005:Topoisomerase II Inhibitors
D054659:Diketopiperazines; D004791:Enzyme Inhibitors; D009363:Neoplasm Proteins; D010879:Piperazines; D064249:Securin; D059005:Topoisomerase II Inhibitors; C070899:4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione; D004250:DNA Topoisomerases, Type II