title: Effect of Mongolian plants on in vivo insulin action in diabetic rats.
abstract: In the present study, we firstly performed a preliminary investigation on the acute effect of Mongolian medicinal plant extracts (Dryopteris species, Aspidiaceae) on the glucose tolerance in rats, evaluated by an oral glucose tolerance test (OGTT). Then, we investigated the effect of the same extracts on in vivo insulin action in streptozotocin (50 mg kg(-1) BW, i.v.)-induced diabetic rats by means of the euglycemic clamp. In diabetic rats, the glucose metabolic clearance rate (MCR) during 3.0 (low-dose) and 30.0 mU kg(-1)min(-1) (high-dose) insulin infusion was significantly higher in animals administered with plant extracts (500 mg kg(-1) BW, p.o.), compared with saline-administered animals (low-dose--normal control: 16.3+/-0.7 ml kg(-1)min(-1) versus plant extract 1: 15.8+/-0.6 ml kg(-1)min(-1) and plant extract 2: 14.0+/-0.5 ml kg(-1)min(-1), diabetic control: 10.9+/-0.6 ml kg(-1)min(-1) versus plant extract 1: 19.3+/-1.4 ml kg(-1)min(-1) and plant extract 2: 20.5+/-1.5 ml kg(-1)min(-1); high-dose-normal control: 50.9+/-2.6 ml kg(-1)min(-1) versus plant extract 1: 49.8+/-2.6 ml kg(-1)min(-1) and plant extract 2: 48.4+/-2.4 ml kg(-1)min(-1), diabetic control: 26.9+/-1.6 ml kg(-1)min(-1) versus plant extract 1: 33.5+/-1.7 ml kg(-1)min(-1) and plant extract 2: 37.2+/-1.9 ml kg(-1)min(-1); P<0.05, respectively). These results suggest that a single administration of the two Mongolian plant extracts can improve glucose utilization and insulin resistance in diabetic rats.
authors.affiliation: Department of Health Science, Faculty of Psychological and Physical Science, Aichi Gakuin University, 12 Araike, Nisshin 470-0195, Japan.
authors.forename: Oyun
authors.initials: O
authors.lastname: Khookhor
authors.forename: Qin
authors.initials: Q
authors.lastname: Bolin
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Oshida
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D017536:Carotid Artery, Common / Q000187:drug effects / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008986:Mongolia; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts