title: Anaplastic secretory meningioma: a case report.
abstract: Secretory meningiomas are rare histological subtypes of meningiomas with benign biological behaviour. In this study, the authors describe the first case of secretory meningioma with many mitotic figures and brain invasion, and discuss the clinicopathologic features including immunohistochemical staining profile and ultrastructural appearance of this tumour. A case of a 54-year-old man diagnosed with an intracranial tumour located in the left frontal lobe is presented. On pre-contrast CT scans, the tumour was hypodense and the contrast enhancement was marked in the pseudo membrane. The tumour was partially removed. The histological diagnosis was secretory meningioma with many mitotic figures, a high MIB-1 labeling index and a brain invasion.
authors.affiliation: Department of Pathology, La Rabta Hospital, 1007 Bab Saadoun, Tunis, Tunisie.
authors.forename: L
authors.initials: L
authors.lastname: Ferchichi
authors.forename: S
authors.initials: S
authors.lastname: Bellil
authors.forename: K
authors.initials: K
authors.lastname: Ben Hammouda
authors.forename: K
authors.initials: K
authors.lastname: Bellil
authors.forename: A
authors.initials: A
authors.lastname: Mekni
authors.forename: I
authors.initials: I
authors.lastname: Bettaieb
authors.forename: S
authors.initials: S
authors.lastname: Haouet
authors.forename: M M
authors.initials: MM
authors.lastname: Khaldi
authors.forename: K
authors.initials: K
authors.lastname: Zitouna
authors.forename: N
authors.initials: N
authors.lastname: Kchir
mesh_terms: D002272:Carcinoembryonic Antigen / Q000032:analysis; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005625:Frontal Lobe / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008579:Meningioma / Q000737:chemistry / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D008940:Mitotic Index; D018396:Mucin-1 / Q000032:analysis; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D018714:Radiotherapy, Adjuvant
chemical_list: D002272:Carcinoembryonic Antigen; D019394:Ki-67 Antigen; D018396:Mucin-1; D009363:Neoplasm Proteins; D007633:Keratins