Molecular mechanisms underlying the immunomodulatory effects of mistletoe (Viscum album L.) extracts Iscador.
Viscum album (VA) preparations (Iscador) consist of aqueous extracts from different types of European mistletoe. Biologically active components of VA extracts include mistletoe lectins (ML) and viscotoxins. The treatment with VA extracts or with purified ML has been shown to be associated with tumor regression in several in vivo experimental models of tumoral implantation. The mechanisms underlying the anti-tumoral activity of VA or ML are complex and involve apoptosis, angiogenesis and immunomodulation. This review provides an account of the current status of the understanding of the VA-associated immunomodulation in various cell types including lymphoblastoid, monocytic or endothelial cell lines.
Elluru
Sriramulu
S
INSERM U681, Université Pierre et Marie Curie, Paris 6, France.
Duong Van Huyen
Jean-Paul
JP
Delignat
Sandrine
S
Prost
Fabienne
F
Bayry
Jagadeesh
J
Kazatchkine
Michel D
MD
Kaveri
Srini V
SV
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors; D009000:Monocytes / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010940:Plant Proteins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects
D020533:Angiogenesis Inhibitors; D007155:Immunologic Factors; D010936:Plant Extracts; D010940:Plant Proteins; C077177:viscum album peptide