title: Structure elucidation of fungal sespendole, an inhibitor of lipid droplet synthesis in macrophages.
abstract: A new fungal metabolite named sespendole was isolated as an inhibitor of lipid droplet synthesis in mouse macrophages from the culture broth of the fungal strain Pseudobotrytis terrestris FKA-25. The structure and stereochemistry of sespendole were elucidated by spectroscopic studies including various NMR spectral analyses, exciton chirality experiments and the modified Mosher method. Sespendole was found to possess a new indolosesquiterpene skeleton modified with two isoprenes.
authors.affiliation: School of Pharmacy, Kitasato University, Tokyo, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uchida
authors.forename: Yong-Pil
authors.initials: YP
authors.lastname: Kim
authors.forename: Tohru
authors.initials: T
authors.lastname: Nagamitsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D050356:Lipid Metabolism / Q000187:drug effects*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008968:Molecular Conformation
chemical_list: D004224:Diterpenes; D007211:Indoles; C510263:sespendole