Effect of obesity on clinical presentation and response to treatment in asthma.
Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.
Dixon
Anne E
AE
University of Vermont, Burlington, VT 05401, USA. anne.dixon@uvm.edu
Shade
David M
DM
Cohen
Rubin I
RI
Skloot
Gwen S
GS
Holbrook
Janet T
JT
Smith
Lewis J
LJ
Lima
John J
JJ
Allayee
Hooman
H
Irvin
Charles G
CG
Wise
Robert A
RA
D000085:Acetates / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D001993:Bronchodilator Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003521:Cyclopropanes; D016207:Cytokines / Q000097:blood; D018450:Disease Progression; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D011804:Quinolines / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology; D013440:Sulfides; D013806:Theophylline / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome; D014797:Vital Capacity / Q000187:drug effects
D000085:Acetates; D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D003521:Cyclopropanes; D016207:Cytokines; D011804:Quinolines; D013440:Sulfides; D013806:Theophylline; C093875:montelukast