Conjunctival low-grade non-Hodgkin's lymphoma: a large single-center study of initial characteristics, natural history and prognostic factors.
To define the initial characteristics and prognostic factors of patients with conjunctival low-grade malignant lymphoma, all patients treated for low-grade lymphoma with initial conjunctival involvement were reviewed. Forty-nine cases were selected, including 45 cases with exclusive ophthalmologic conjunctival involvement. Pathologic review showed 55% of mucosa-associated lymphoid tissue type lymphoma, and 23% of lymphoplasmocytic lymphoma. Initial characteristics were median age of 62 years, nodal involvement in 17% of cases, and stage IV in 22% of patients with 10% of bone marrow involvement. With a median follow-up of 75 months, the 5-year disease-free survival (DFS) and overall survival were 65% and 83%, respectively. On multivariate analysis, nodal involvement was the only factor with a pejorative impact on DFS. Our patient cohort represents one of the largest published series defining the characteristics and prognostic factors of primary conjunctival low-grade malignant lymphoma.
Meunier
Jérôme
J
Department of Clinical Hematology, Institut Curie, Paris, France.
Lumbroso-Le Rouïc
Livia
L
Dendale
Rémi
R
Vincent-Salomon
Anne
A
Asselain
Bernard
B
Arnaud
Philippe
P
Némati
Fariba
F
Fourquet
Alain
A
Desjardins
Laurence
L
Plancher
Corine
C
Levy
Christine
C
Chaoui
Driss
D
Validire
Patricia
P
Decaudin
Didier
D
D000367:Age Factors; D003230:Conjunctival Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome