The adipose tissue as an endocrine organ--a nephrologists' perspective.
During the last decade white adipose tissue was recognized as an active endocrine organ and a source of many proinflammatory cytokines, chemokines, growth factors and complement proteins called 'adipokines' or 'adipocytokines'. The contribution of different cell types which compose the adipose tissue: adipocytes, preadipocytes, stromal/vascular cells and macrophages in secretion of above-mentioned adipokines varies remarkably. These adipokines seem to play an important role in the pathogenesis of obesity-related comorbidities. In this review, we have summarized the present knowledge on the most important adipokines in patients with obesity, arterial hypertension and chronic kidney diseases.
Chudek
Jerzy
J
Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland.
Adamczak
Marcin
M
Nieszporek
Teresa
T
Wiecek
Andrzej
A
D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D004703:Endocrine System / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology*; D009398:Nephrology; D009765:Obesity / Q000150:complications / Q000503:physiopathology*