title: A homology model of SERT based on the LeuT(Aa) template.
abstract: A human serotonin transporter (SERT) model has been constructed based on the crystal structure of the bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters from Aquifex aeolicus (LeuT(Aa)). Amino acids in the ligand binding area predicted by ICM pocket finder included Tyr95, Ala96, Asp98, Gly100 (transmembrane helix (TMH) 1), Ala169, Ile172, Ala173, Tyr176 (TMH3), Phe335, Ser336, Gly338, Phe341, Val343 (TMH6), Thr439, Ala441, and Gly442 (TMH8). The present model is an updated working tool for experimental studies on SERT.
authors.affiliation: Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway.
authors.forename: Aina Westrheim
authors.initials: AW
authors.lastname: Ravna
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Jaronczyk
authors.forename: Ingebrigt
authors.initials: I
authors.lastname: Sylte
mesh_terms: D001419:Bacteria / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008958:Models, Molecular; D050480:Plasma Membrane Neurotransmitter Transport Proteins / Q000737:chemistry* / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000737:chemistry* / Q000235:genetics; D040681:Structural Homology, Protein
chemical_list: D050480:Plasma Membrane Neurotransmitter Transport Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins