Stereoselective synthesis of novel beta,gamma-epoxyhydroxylamines and 4-hydroxyalkyl-1,2-oxazetidines.
A simple and efficient stereoselective synthesis of polysubstituted beta,gamma-epoxyhydroxylamines and 4-hydroxyalkyl-1,2-oxazetidines, based on the addition of alpha-lithiated aryloxiranes to nitrones and subsequent cyclization of the corresponding intermediates in a 4-exo-tet mode, is described.
Capriati
Vito
V
Dipartimento Farmaco-Chimico, Università di Bari, C.N.R., Istituto di Chimica dei Composti OrganoMetallici "ICCOM", Sezione di Bari, Via E. Orabona 4, I-70125-Bari, Italy.
Florio
Saverio
S
Luisi
Renzo
R
Salomone
Antonio
A
Cuocci
Corrado
C