Chromium(III) complexes of D-glucosaminic acid and their effect on decreasing blood sugar in vivo.
Two chromium(III) complexes of glucosaminic acid were synthesized by neutralization and exchange reaction. The formation of 1 : 1 and 2 : 3 (Cr : glucosaminate) complexes was confirmed by elemental analyses and spectroscopic studies. The effect of the complexes on decreasing blood sugar was investigated on type-2 diabetes model rats induced by tetraoxypyrimidine. The results indicated that the effect on decreasing blood sugar was comparable to that of picolinate chromium complex (Cr(pic)(3)) currently used world wide.
Ou
Sheng-Ju
SJ
Coordination Chemistry Institute, The State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Chen
Guang
G
Lin
Zhi-Hua
ZH
Bai
Zhi-Ping
ZP
Duan
Chun-Ying
CY
Mao
Cai-Ping
CP
D000496:Alloxan / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D017608:Chromium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D004195:Disease Models, Animal; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D010848:Picolinic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
D001786:Blood Glucose; D017608:Chromium Compounds; D010848:Picolinic Acids; C035547:glucosaminic acid; D000496:Alloxan; D005944:Glucosamine