title: Auditory P300 latency prolongation with age in schizophrenia: gender and subcomponent effects.
abstract: Previous studies showing prolongation of auditory P300b latency with increasing age provided support for post-onset progressive change in schizophrenia. We sought to extend the findings by evaluating the effects of gender and the subcomponents (P3b versus P3a) in schizophrenia (N=108) and controls (N=70). P3b latency significantly correlated with age in schizophrenia (Spearman's rho=0.214, P=0.026) and in male patients with schizophrenia (rho=0.260, P=0.049) whereas, it did not reach significance in female patients with schizophrenia (rho=0.174, P=0.23). P3a latency showed no correlation. Our findings may provide evidence for progressive change in the brain function in schizophrenia, and this change may be slower in female than male patients. P3b may serve as a more sensitive index for cognitive decline than P3a.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. taraki-tky@umin.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Araki
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Kenji
authors.initials: K
authors.lastname: Kirihara
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yamasue
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Noriko
authors.initials: N
authors.lastname: Kudo
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nakagome
authors.forename: Akira
authors.initials: A
authors.lastname: Iwanami
mesh_terms: D000328:Adult; D004569:Electroencephalography; D004585:Electrooculography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000503:physiopathology*; D012737:Sex Factors