title: [Risk factors for incident cervical intraepithelial neoplasia (CIN) among HIV-infected women: a prospective study].
abstract: OBJECTIVE
  To study risk factors for incident cervical intraepithelial neoplasia (CIN) among HIV-infected women.
  
  
  METHODS
  Prospective study of a population of 97 HIV-infected women with normal Pap smear at inclusion.
  
  
  RESULTS
  Fourteen CIN (diagnosed by colposcopy and confirmed with biopsy) were observed within a median follow-up of 38 months (13 CIN 1, one CIN 2). The incidence of cervical lesions was estimated to be 2%, 7% and 10% respectively at one year, two and three years after inclusion, The time to occurrence was very variable (ranging from 7 months to 6 years) among our patients. No known risk factors, in particular neither the CD4 cell count nor antiretroviral treatment, were identified to be associated with occurrence of CIN in our study population.
  
  
  CONCLUSIONS
  Regardless of their immune status and HIV treatments, extensive and prolonged gynaecological follow up of HIV-infected women remains necessary.
authors.affiliation: Service de Médecine Interne, Hôpital de Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin Bicêtre Cedex. dr.sfridmann@wanadoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Fridmann
authors.forename: F
authors.initials: F
authors.lastname: Boufassa
authors.forename: I
authors.initials: I
authors.lastname: Cartier
authors.forename: D
authors.initials: D
authors.lastname: Peretti
authors.forename: T
authors.initials: T
authors.lastname: Lazure
authors.forename: M
authors.initials: M
authors.lastname: Mole
authors.forename: J-F
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: C
authors.initials: C
authors.lastname: Goujard
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology*