Solitary mandibular metastasis as an initial manifestation of hepatocellular carcinoma.
Oral metastases from hepatocellular carcinoma are very rare. We encountered a case of hepatocellular carcinoma with a solitary metastasis to the mandible as an initial manifestation. The patient was a 76-year-old man who was admitted for left mandibular swelling. A biopsy specimen of mandible was suspected to be a metastatic tumor. The histological findings, abdominal computed tomography, bone scintigraphy, and F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed it to be a solitary metastasis from hepatocellular carcinoma. As a result, he was diagnosed to have liver cirrhosis due to a hepatitis C virus infection and hepatocellular carcinoma with a solitary metastasis to the mandible. The primary lesion was treated with transcatheter arterial embolization (TAE), and the metastasis to the mandible was surgically resected. The patient survived for 9 months after treatment without recurrence.
Teshigawara
Katsunobu
K
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Kakizaki
Satoru
S
Sohara
Naondo
N
Hashida
Tetsu
T
Tomizawa
Yoshio
Y
Sato
Ken
K
Takagi
Hitoshi
H
Mori
Masatomo
M
Hoshino
Keiko
K
Mogi
Kenji
K
D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008339:Mandibular Neoplasms / Q000473:pathology / Q000556:secondary*