title: Familial inclusion body myositis in a mother and son with different ancestral MHC haplotypes.
abstract: An Ashkenazi Jewish family in which the mother and a son both have inclusion body myositis (IBM) is reported. The condition developed at an earlier age and was more rapidly progressive and less responsive to treatment in the son than in the mother or other IBM patients in our clinic. Genetic analysis showed that the mother carried alleles of the 8.1 MHC ancestral haplotype (AH; HLA-B8, DRB1*0301), which is found in 85% of IBM patients in Western Australia. The son did not inherit this haplotype, but carried alleles characteristic of the 52.1AH (HLA-B5, DRB1*1502) of paternal origin. The findings indicate that in this family either the 8.1AH or 52.1AH may carry susceptibility for IBM and that the 52.1AH is associated with a more severe and treatment-resistant form of the disease.
authors.affiliation: Centre for Neuromuscular and Neurological Disorders, University of Western Australia, 4th Floor, A Block, Queen Elizabeth II Medical Centre, Nedlands WA 6009, Australia. flmast@cyllene.uwa.edu.au
authors.forename: Frank
authors.initials: F
authors.lastname: Mastaglia
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
authors.forename: Susan
authors.initials: S
authors.lastname: Walters
authors.forename: Vicki
authors.initials: V
authors.lastname: Fabian
authors.forename: James
authors.initials: J
authors.lastname: Miller
authors.forename: Paul
authors.initials: P
authors.lastname: Zilko
mesh_terms: D000483:Alleles; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007585:Jews / Q000235:genetics; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D018979:Myositis, Inclusion Body / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D014904:Western Australia