Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities.
Two new taraxasterane-type triterpenes, 20beta,28-epoxy-28alpha-methoxytaraxasteran-3beta-ol (1) and 20beta,28-epoxytaraxaster-21-en-3beta-ol (2), were isolated from an ethyl acetate extract of the leaves of Nerium oleander, together with ursane-type triterpenes, 28-nor-urs-12-ene-3beta,17beta-diol (3) and 3beta-hydroxyurs-12-en-28-aldehyde (4). The structures of 1 and 2 were established on the basis of their spectroscopic data. Anti-inflammatory activity of 1-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1). Cytotoxic activity of 1-4 was evaluated against four human cell lines, A-549, WI-38, VA-13, and HepG2 cells.
Zhao
Ming
M
Graduate School of Science and Technology, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan.
Zhang
Shujun
S
Fu
Liwei
L
Li
Na
N
Bai
Jiao
J
Sakai
Junichi
J
Wang
Liyan
L
Tang
Wanxia
W
Hasegawa
Toshiaki
T
Ogura
Hirotsugu
H
Kataoka
Takao
T
Oka
Seiko
S
Kiuch
Miwa
M
Hirose
Katutoshi
K
Ando
Masayoshi
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects; D007564:Japan; D015394:Molecular Structure; D030007:Nerium / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C513759:20beta,28-epoxy-28alpha-methoxytaraxasteran-3beta-ol; C513760:20beta,28-epoxytaraxaster-21-en-3beta-ol; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D018799:Intercellular Adhesion Molecule-1