Mechanism of transcriptional activation by the Myc oncoproteins.
The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities.
Cowling
Victoria H
VH
Department of Pharmacology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA.
Cole
Michael D
MD
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D002843:Chromatin / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D048868:Adaptor Proteins, Signal Transducing; D002843:Chromatin; D009687:Nuclear Proteins; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; C113829:transformation-transcription domain-associated protein