[Eukaryotic ribosomal proteins: interaction with their own pre-mRNAs and involvement in the splicing regulation].
The present review summarizes data concerning regulation of eukaryotic ribosomal protein genes expression at the splicing step, including own results. In particular, roles of the ribosomal proteins in regulation of splicing of their coding pre-mRNAs are considered. Special attention is devoted to discussion of the molecular mechanisms that underlie the process and to the analysis of interactions of ribosomal proteins with their own pre-mRNAs and mRNAs. Besides, critical consequences arising by disturbances in the mechanisms of regulation of ribosomal proteins biosynthesis in the cell are noted in the review. Special role of autoregulation in the maintenance of the normal level of ribosomal protein biosynthesis is underlined in the conclusion.
Ivanov
A V
AV
Malygin
A A
AA
Karpova
G G
GG
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D014176:Protein Biosynthesis; D011487:Protein Conformation; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism
D012322:RNA Precursors; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins