Leptin, estrogens and cancer.
Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.
Maeso Fortuny
María del Carmen
MC
Unidad de investigación, Hospital de La Candelaria, Santa Cruz de Tenerife, Spain. antonio.cabreradeleon@gobiernodecanarias.org
Brito Díaz
Buenaventura
B
Cabrera de León
Antonio
A
D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D020930:MAP Kinase Kinase Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism*; D009765:Obesity / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D054411:Receptors, Leptin; D050791:STAT Transcription Factors / Q000378:metabolism
D004791:Enzyme Inhibitors; D004967:Estrogens; C515448:LEPR protein, human; D020738:Leptin; D008055:Lipids; D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D054411:Receptors, Leptin; D050791:STAT Transcription Factors; D011505:Protein-Tyrosine Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D020930:MAP Kinase Kinase Kinases; D020929:Mitogen-Activated Protein Kinase Kinases