Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives.
5-Dimethylamino-1-aminoindan undergoes thermal decomposition and reacts with 6-chlorouracil to give 5-indanyl-6-chlorouracil derivative 9. The formation of 9 may be rationalized by a putative mechanism based on the intermediacy of the imminium methide species 8a.
Ulanenko
Konstantin
K
Global Innovative R & D, Teva Pharmaceutical Industries Ltd., Netanya 42504, Israel.
Falb
Eliezer
E
Gottlieb
Hugo E
HE
Herzig
Yaacov
Y
D002625:Chemistry, Organic / Q000379:methods*; D004123:Dimethylamines / Q000737:chemistry*; D007189:Indans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry*
D004123:Dimethylamines; D007189:Indans; D014498:Uracil; C034516:dimethylamine; C093582:indan