title: Silent spread of H5N1 in vaccinated poultry.
abstract: International debate on the merits of vaccinating poultry against the H5N1 influenza A virus has raised concerns about the possibility of an increased risk of between-flock transmission before outbreaks are detected. Here we show that this 'silent spread' can occur because of incomplete protection at the flock level, even if a vaccine is effective in individual birds. The use of unvaccinated sentinels can mitigate, although not completely eliminate, the problem.
authors.affiliation: Centre for Infectious Diseases, University of Edinburgh, Ashworth Laboratories, The King's Buildings, Edinburgh EH9 3JT, UK. nick.savill@ed.ac.uk
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Savill
authors.forename: Suzanne G
authors.initials: SG
authors.lastname: St Rose
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Keeling
authors.forename: Mark E J
authors.initials: ME
authors.lastname: Woolhouse
mesh_terms: D000818:Animals; D002645:Chickens / Q000276:immunology / Q000821:virology; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology / Q000502:physiology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D005585:Influenza in Birds / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission* / Q000821:virology; D018571:Sentinel Surveillance
chemical_list: D007252:Influenza Vaccines