title: Highly porous 3D nanofiber scaffold using an electrospinning technique.
abstract: A successful 3D tissue-engineering scaffold must have a highly porous structure and good mechanical stability. High porosity and optimally designed pore size provide structural space for cell accommodation and migration and enable the exchange of nutrients between the scaffold and environment. Poly(epsilon-carprolactone) fibers were electrospun using an auxiliary electrode and chemical blowing agent (BA), and characterized according to porosity, pore size, and their mechanical properties. We also investigated the effect of the BA on the electrospinning processability. The growth characteristic of human dermal fibroblasts cells cultured in the webs showed the good adhesion with the blown web relative to a normal electrospun mat. The blown nanofiber web had good tensile properties and high porosity compared to a typical electrospun nanofiber scaffold.
authors.affiliation: Bio-mechatronics Laboratory, Department of Future Technology, Korea Institute of Machinery and Materials, Yuseong-Gu, Daejeon, Korea. gkim@kimm.re.kr
authors.forename: Geunhyung
authors.initials: G
authors.lastname: Kim
authors.forename: WanDoo
authors.initials: W
authors.lastname: Kim
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D049109:Cell Proliferation; D002498:Centrifugation / Q000379:methods*; D004560:Electricity; D004566:Electrodes; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D011091:Polyesters / Q000737:chemistry*; D016062:Porosity; D012867:Skin / Q000166:cytology; D023822:Tissue Engineering
chemical_list: D001391:Azo Compounds; D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; C004525:azodicarbonamide