The recurrence of cervical intraepithelial neoplasia in HIV-positive women: a review of the literature.
The objective of this study was to assess the available evidence on the outcome of cervical intraepithelial neoplasia (CIN) in HIV-positive women after conization. We performed a literature search of Medline and Cochrane libraries to locate published articles reporting about the rate of recurrence of CIN after excisional treatment in patients with negative surgical margins. Out of 15 articles, five studies reported recurrence rate of CIN in margin negative patients. The recurrence rate of CIN after conization in HIV-infected women ranges from 20% to 75%. No conclusions can be drawn about the impact of CD4 cell counts on the recurrence rate. Available evidence suggests that standard excisional treatments for CIN are associated with high rates of recurrence in HIV-positive women. Despite the fact that the evidence is limited because of the few number of eligible studies, this issue should be considered in the management of HIV-positive patient with CIN.
Tebeu
Pierre Marie
PM
Department of Obstetrics and Gynaecology, Geneva University Hospitals, Geneva, Switzerland.
Major
Attila L
AL
Mhawech
Paulette
P
Rapiti
Elisabetta
E
D019092:Conization; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000601:surgery / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000601:surgery / Q000821:virology*