title: Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome.
abstract: OBJECTIVE
  Platelet collagen receptor glycoprotein VI (GPVI) is critical for the formation of arterial thrombosis. In this observational study, we examined the platelet surface expression of GPVI in patients with symptomatic coronary artery disease (CAD).
  
  
  RESULTS
  We evaluated a consecutive cohort of 367 patients with symptomatic CAD, who underwent coronary angiography. The surface expression of platelet activation markers (GPVI, CD62P, and CD42b) was determined by flow cytometry. Patients with acute coronary syndrome (ACS) showed a significantly enhanced GPVI expression on admission when compared with patients with stable angina pectoris (SAP) (ACS: 21.4+/-9.7; SAP: 18.6+/-7.1 mean fluorescence intensity+/-SD; P=0.004). The expression of GPVI correlated with CD62P (r=0.702; P=0.001). Logistic regression analysis demonstrated that on admission, elevated platelet GPVI expression was associated with ACS, independent of markers of myocardial necrosis such as troponin and creatine kinase.
  
  
  CONCLUSIONS
  Platelet GPVI surface expression is elevated in patients with ACS and is associated with imminent acute coronary events. The determination of the platelet-specific thrombotic marker GPVI may help to identify patients at risk before myocardial ischaemia is evident.
authors.affiliation: Medizinische Klinik III, Eberhard Karls-Universität Tübingen, Otfried-Müller-Str. 10, D-72076 Tübingen, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Bigalke
authors.forename: Stephan
authors.initials: S
authors.lastname: Lindemann
authors.forename: Raila
authors.initials: R
authors.lastname: Ehlers
authors.forename: Peter
authors.initials: P
authors.lastname: Seizer
authors.forename: Karin
authors.initials: K
authors.lastname: Daub
authors.forename: Harald
authors.initials: H
authors.lastname: Langer
authors.forename: Tanja
authors.initials: T
authors.lastname: Schonberger
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Kremmer
authors.forename: Dorothea
authors.initials: D
authors.lastname: Siegel-Axel
authors.forename: Andreas E
authors.initials: AE
authors.lastname: May
authors.forename: Meinrad
authors.initials: M
authors.lastname: Gawaz
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D018955:CD36 Antigens / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D018955:CD36 Antigens