Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor.
Three deoxyglucose (DG) derivatives, S-DG, MAG(3)-DG and MAMA-BA-DG, were synthesized and labeled successfully with high labeling yields and high radio-chemical purities. Biodistribution in tumor-bearing mice demonstrated that these three new (99m)Tc-deoxyglucose derivatives showed accumulation in tumor and high tumor-to-muscle ratios. Among them, the (99m)Tc-MAG(3)-DG showed the best characteristics as a potential tumor marker for single photon emission computed tomography (SPECT).
Chen
Xiangji
X
Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, PR China.
Li
Liang
L
Liu
Fei
F
Liu
Boli
B
D000818:Animals; D003287:Contrast Media; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D003952:Diagnostic Imaging; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis*; D051379:Mice; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon
D003287:Contrast Media; D013667:Technetium; D003847:Deoxyglucose