title: Primary sciatic nerve lymphoma: a case report and review of the literature.
abstract: A patient with primary B cell non-Hodgkin's lymphoma of the sciatic nerve is described. He presented with neuropathic symptoms in the left leg, initially diagnosed as tarsal tunnel syndrome. Magnetic resonance imaging (MRI) identified the abnormality in the sciatic nerve. A fascicular biopsy of the sciatic nerve showed a diffuse large B cell non-Hodgkin's lymphoma. The patient was treated with chemotherapy and rituximab (anti-CD20 monoclonal antibody). Four months later he was in remission, and remains so 48 months from presentation. Primary lymphoma of single peripheral nerves may be a unique subtype of extranodal lymphoma, which usually follows an aggressive course and has a variable response to current therapeutic strategies. MRI is useful, alongside electrophysiological studies, in patients with atypical peripheral nerve symptoms.
authors.affiliation: Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
authors.forename: M J L
authors.initials: MJ
authors.lastname: Descamps
authors.forename: L
authors.initials: L
authors.lastname: Barrett
authors.forename: M
authors.initials: M
authors.lastname: Groves
authors.forename: L
authors.initials: L
authors.lastname: Yung
authors.forename: R
authors.initials: R
authors.lastname: Birch
authors.forename: N M F
authors.initials: NM
authors.lastname: Murray
authors.forename: D C
authors.initials: DC
authors.lastname: Linch
authors.forename: M P T
authors.initials: MP
authors.lastname: Lunn
authors.forename: M M
authors.initials: MM
authors.lastname: Reilly
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010524:Peripheral Nervous System Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D000069283:Rituximab; D012584:Sciatic Nerve / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab