title: [Comparison of clinical findings between autoimmune pancreatitis with bile duct involvement and primary sclerosing cholangitis].
abstract: OBJECTIVE
  The involvement of bile ducts is frequently reported in autoimmune pancreatitis (AIP), which seem to have similar features to primary sclerosing cholangitis (PSC). Recent systematic comparative studies about these diseases are rare in Korea.
  
  
  METHODS
  We retrospectively analyzed 26 patients with AIP with bile duct involvement and 30 patients with classic PSC who were diagnosed during the last decade.
  
  
  RESULTS
  The mean age of patients was significantly higher in AIP than PSC at the time of diagnosis. There was a preponderance of men in both group, which was more prominent in AIP. The most common symptom in patients with AIP was jaundice, but PSC patients usually visited hospitals due to incidentally detected abnormal liver function tests. Most (26/31) of AIP had bile duct involvement. All of these patients showed narrowing of intrapancreatic common bile ducts and one patient exhibited hilar involvement as well. About 80% of PSC had both intra- and extrahepatic ducts involvement, and the characteristic features involve multifocal strictures. AIP patients showed improvement with steroid treatment, however, most PSC patients showed clinical deterioration.
  
  
  CONCLUSIONS
  The clinical and cholangiographic findings of patients with AIP and PSC have many different characteristics. Therefore, further study of two diseases is required for the proper diagnosis and management.
authors.affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Korea.
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Myung-Hwan
authors.initials: MH
authors.lastname: Kim
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Jung
authors.forename: Ju Hyung
authors.initials: JH
authors.lastname: Song
authors.forename: Hyoung-Chul
authors.initials: HC
authors.lastname: Oh
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kwon
authors.forename: Tae Yoon
authors.initials: TY
authors.lastname: Lee
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Lee
authors.forename: Dong Wan
authors.initials: DW
authors.lastname: Seo
authors.forename: Sung Koo
authors.initials: SK
authors.lastname: Lee
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D001652:Bile Ducts / Q000473:pathology; D002758:Cholangiography; D002760:Cholangiopancreatography, Endoscopic Retrograde; D015209:Cholangitis, Sclerosing / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D010195:Pancreatitis / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D007136:Immunoglobulins