title: Vasoinhibins: endogenous regulators of angiogenesis and vascular function.
abstract: Vasoinhibins are a family of peptides derived from prolactin, growth hormone and placental lactogen that act on endothelial cells to suppress vasodilation and angiogenesis and to promote apoptosis-mediated vascular regression. Some of the pathways by which vasoinhibins act have now been defined, and recent developments indicate that endogenous vasoinhibins exert tonic and essential actions on blood vessel growth, dilation and regression in vivo. By studying the pathways that can generate vasoinhibins, and the nature of their receptors and key biological mediators, it should be possible to clarify the role of vasoinhibins in controlling vascular function in health and disease.
authors.affiliation: Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Querétaro 76230, México. clapp@servidor.unam.mx
authors.forename: Carmen
authors.initials: C
authors.lastname: Clapp
authors.forename: Jorge
authors.initials: J
authors.lastname: Aranda
authors.forename: Carmen
authors.initials: C
authors.lastname: González
authors.forename: Michael C
authors.initials: MC
authors.lastname: Jeziorski
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Martínez de la Escalera
mesh_terms: D043924:Angiogenesis Modulating Agents / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D013006:Growth Hormone / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D018919:Neovascularization, Physiologic; D010928:Placental Lactogen / Q000737:chemistry / Q000502:physiology*; D011388:Prolactin / Q000737:chemistry / Q000502:physiology*; D011485:Protein Binding; D015398:Signal Transduction; D014662:Vasoconstrictor Agents / Q000737:chemistry / Q000378:metabolism
chemical_list: D043924:Angiogenesis Modulating Agents; D014662:Vasoconstrictor Agents; D011388:Prolactin; D013006:Growth Hormone; D010928:Placental Lactogen