Novel conserved assembly factor of the bacterial flagellum.
TP0658 (FliW) and its orthologs, conserved proteins of unknown function in Treponema pallidum and other species, interact with a C-terminal region of flagellin (FlaB1-3 in T. pallidum; FliC in most other species). Mutants of orthologs in Bacillus subtilis and Campylobacter jejuni (yviF, CJ1075) showed strongly reduced motility. TP0658 stabilizes flagellin in a way similar to FliS, suggesting that TP0658 is a conserved assembly factor for the bacterial flagellum.
Titz
Björn
B
Institute of Genetics, Forschungszentrum Karlsruhe, Box 3640, D-76021 Karlsruhe, Germany.
Rajagopala
Seesandra V
SV
Ester
Claudia
C
Häuser
Roman
R
Uetz
Peter
P
D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D016123:Campylobacter jejuni / Q000235:genetics / Q000502:physiology; D005407:Flagella / Q000235:genetics / Q000502:physiology*; D005408:Flagellin / Q000378:metabolism*; D009068:Movement; D014210:Treponema pallidum / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure
D001426:Bacterial Proteins; D005408:Flagellin