Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.
The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.
Lindegardh
Niklas
N
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand. niklas@tropmedres.ac
Davies
Geraint R
GR
Tran
Tinh Hien
TH
Farrar
Jeremy
J
Singhasivanon
Pratap
P
Day
Nicholas P J
NP
White
Nicholas J
NJ
D000328:Adult; D000998:Antiviral Agents / Q000097:blood / Q000493:pharmacokinetics*; D004950:Esterases / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D010755:Organophosphates / Q000097:blood / Q000493:pharmacokinetics; D053139:Oseltamivir / Q000097:blood / Q000493:pharmacokinetics*; D011355:Prodrugs / Q000493:pharmacokinetics*
D000998:Antiviral Agents; D010755:Organophosphates; D011355:Prodrugs; D053139:Oseltamivir; D004950:Esterases