[The congenital morphogenetic variants and genetic polymorphism of the system of xenobiotic detoxication in children living in dioxin-contaminated regions of South Vietnam].
The presence of dioxins and dioxin-containing ecotoxicants (DCE) in human environment leads to multi-level homeostasis disbalance and, eventually, dioxin pathology (DP) develops. This was demonstrated for the adult population of South Vietnam (1), who had suffered from the use of military chlorphenoxiherbicides to which dioxins had been added. The subjects of this study were children who belonged to the second generation of the inhabitants of DCE-polluted South Vietnam areas. In this sample, the frequency of malformations depending on two factors, genes GSTMI, GSTT1, CYP1A1 genotypes, and DCE exposure, were estimated. The study demonstrates that an increased level of congenital morphogenetic variants per one child is associated with the presence of DCE in the environment, as well as the fact that this parameter is influenced by genotypes of xenobiotic detoxication genes.
Zhuchenko
N A
NA
Umnova
N V
NV
Rumak
V S
VS
Revazova
Iu A
IuA
Sidorova
I E
IE
Khripach
L V
LV
Lazarenko
D Iu
DIu
Sofronov
G A
GA
D000483:Alleles; D002648:Child; D002675:Child, Preschool; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004147:Dioxins / Q000506:poisoning*; D004781:Environmental Exposure / Q000009:adverse effects*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008658:Inactivation, Metabolic; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D014744:Vietnam; D015262:Xenobiotics / Q000506:poisoning*
D019363:Cytochrome P-450 CYP1A1; D004147:Dioxins; D005982:Glutathione Transferase; D015262:Xenobiotics; C413545:glutathione S-transferase T1