title: Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.
abstract: Genetic factors may influence the liability to treatment outcome and medical complications in alcoholism. In the present study we investigated the IL-1A rs1800587, IL-1B rs3087258, TNF-alpha rs1799724 and the HTTLPR variants in a sample of 64 alcohol dependents and 47 relatives versus a set of clinical parameters and outcome measures. Alcohol dependents had a less favorable clinical profile compared to relatives (higher cholesterol, triglycerides, glucose, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyltransferase). After detoxification, all clinical indexes improved and hepatic enzyme levels were similar in alcohol dependents and relatives, except for the GGT that remained significantly higher in alcohol dependents. Alcoholic depressive and anxiety scores were significantly reduced after detoxification. IL-1A, IL-1B, TNF-alpha and HTTLPR variants were not associated with any baseline clinical index or change after detoxification. In our sample IL-1A, IL-1B, TNF-alpha and HTTLPR do not appear as liability factors for alcohol toxicity or detoxification outcome, however the small sample size may influence the observed results.
authors.affiliation: Institute of Psychiatry, University of Bologna, Bologna, Italy. alessandro.serretti@unibo.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Ioannis
authors.initials: I
authors.lastname: Liappas
authors.forename: Laura
authors.initials: L
authors.lastname: Mandelli
authors.forename: Diego
authors.initials: D
authors.lastname: Albani
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.forename: Petros
authors.initials: P
authors.lastname: Malitas
authors.forename: Christina
authors.initials: C
authors.lastname: Piperi
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Zisaki
authors.forename: Elias O
authors.initials: EO
authors.lastname: Tzavellas
authors.forename: Zeta
authors.initials: Z
authors.lastname: Papadopoulou-Daifoti
authors.forename: Francesca
authors.initials: F
authors.lastname: Prato
authors.forename: Sara
authors.initials: S
authors.lastname: Batelli
authors.forename: Marzia
authors.initials: M
authors.lastname: Pesaresi
authors.forename: Anastasios
authors.initials: A
authors.lastname: Kalofoutis
mesh_terms: D000328:Adult; D020268:Alcohol-Induced Disorders, Nervous System / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D000437:Alcoholism / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D002784:Cholesterol / Q000378:metabolism; D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D004351:Drug Resistance / Q000235:genetics / Q000276:immunology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic / Q000502:physiology; D007375:Interleukin-1 / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013375:Substance Withdrawal Syndrome / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D014280:Triglycerides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D050486:Serotonin Plasma Membrane Transport Proteins; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol; D005947:Glucose