title: Time-kill assay of itraconazole against Malassezia species.
abstract: The in vitro pharmacodynamic activity of itraconazole against Malassezia was determined by time-kill methods. Itraconazole showed fungistatic activity at concentrations greater than 2x minimum inhibitory concentration (MIC) for each of the isolates of all nine Malassezia species associated with humans. A concentration exceeding 4x MIC decreased the growth to less than the inoculum amount (1 x 10(5) cells/ml).
authors.affiliation: Department of Microbiology, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan. sugita@my-pharm.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
authors.forename: Hisae
authors.initials: H
authors.lastname: Tsubuku
authors.forename: Mami
authors.initials: M
authors.lastname: Tajima
authors.forename: Ryoji
authors.initials: R
authors.lastname: Tsuboi
authors.forename: Akemi
authors.initials: A
authors.lastname: Nishikawa
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000494:pharmacology*; D008290:Malassezia / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole