Anti-atherosclerotic effect of a new synthetic functional oil containing mono- and diacylglycerol from corn oil.
Synthetic oil containing diacylglycerol and monoacylglycerol, called 'functional oil' (FO), was newly produced and evaluated for its putative anti-atherosclerotic potential by in vitro assays and in vivo test using hypercholesterolemic mice (C57BL/6). The FO revealed good inhibitory activities against both liver acyl-CoA:cholesterol acyltransferase and serum lipoprotein-associated phospholipase A2. The FO showed enhanced activities on lipoprotein interaction such as HDL particle rearrangement to produce different sizes of HDL species. In control mice, hypercholesterolemia was induced by consumption of high-cholesterol, high-fat (HCHF) diet that contained 1.25% cholesterol/15% fat/0.5% Na-cholate with or without 5% of corn oil. In experimental mice, 5% of the FO + HCHF diet was fed during the same period. After the 4-week administration of the diet, serum total cholesterol concentration of the FO-fed group decreased by 38 or 20% when compared to the HCHF diet control group or corn oil (99.9% of triacylglycerol) diet group, respectively. The percentage of HDL cholesterol to total cholesterol was 36% of HDL cholesterol in the FO-fed group, while the HCHF control group and corn oil-fed group showed 21 and 25%, respectively. These results indicate that the FO possesses a blood cholesterol-lowering effect in mouse model and inhibition effects against the atherogenic enzymes.
Cho
Kyung-Hyun
KH
School of Biotechnology, Yeungnam University, Gyeongsan, South Korea.
Han
Jong-Min
JM
Jeong
Tae-Sook
TS
Kim
Hyoung-Chin
HC
Lee
Jong-Ho
JH
Lee
Jeung-Hee
JH
Lee
Ki-Teak
KT
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D050197:Atherosclerosis / Q000178:diet therapy / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003314:Corn Oil / Q000737:chemistry*; D004075:Diglycerides / Q000494:pharmacology* / Q000502:physiology; D004195:Disease Models, Animal; D006937:Hypercholesterolemia / Q000178:diet therapy*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D050178:Monoglycerides / Q000494:pharmacology* / Q000502:physiology; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D011897:Random Allocation; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D004075:Diglycerides; D050178:Monoglycerides; D003314:Corn Oil; D002784:Cholesterol; D002785:Sterol O-Acyltransferase; D010741:Phospholipases A; D054467:Phospholipases A2