Activity of picolinic acid in combination with the antiprotozoal drug quinacrine against Mycobacterium avium complex.
We studied the in vitro and in vivo antimicrobial activities of picolinic acid (PA) in combination with the antiprotozoal drug quinacrine against intramacrophage Mycobacterium avium complex (MAC). Quinacrine significantly potentiated the anti-MAC activity of PA, suggesting the usefulness of this combination in the clinical control of MAC infection.
Shimizu
Toshiaki
T
Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan.
Tomioka
Haruaki
H
D000818:Animals; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008809:Mice, Inbred C3H; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy*; D010848:Picolinic Acids / Q000494:pharmacology*; D011796:Quinacrine / Q000494:pharmacology*
D010848:Picolinic Acids; D011796:Quinacrine; C030614:picolinic acid