Myc in model organisms: a view from the flyroom.
The Myc transcription factor regulates fundamental processes in a cell's life: its growth, division, and survival. Myc is conserved throughout metazoan phyla, and its identification in the fruit fly, Drosophila melanogaster has led to new insights in Myc's physiological roles. In this review, we describe recent research on the biology of Myc and its family members in Drosophila, paying particular attention to its role in the control of growth during development.
de la Cova
Claire
C
Department of Genetics & Development, Columbia University Medical Center, New York, NY 10032, USA.
Johnston
Laura A
LA
D000818:Animals; D030801:Animals, Genetically Modified; D029721:Drosophila Proteins / Q000502:physiology*; D004331:Drosophila melanogaster / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators
D029721:Drosophila Proteins; D016271:Proto-Oncogene Proteins c-myc; D015534:Trans-Activators