title: High-level mupirocin resistance within methicillin-resistant Staphylococcus aureus pandemic lineages.
abstract: The methicillin-resistant Staphylococcus aureus (MRSA) population in the Hospital Universitario Nuestra Señora de Candelaria over a 5-year period (1998 to 2002) was marked by shifts in the circulation of pandemic clones. Here, we investigated the emergence of high-level mupirocin resistance (Hi-Mup(r)). In addition to clonal spread, transfer of ileS2-carrying plasmids played a significant role in the dissemination of Hi-Mup(r) among pandemic MRSA lineages.
authors.affiliation: Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pérez-Roth
authors.forename: Celeste
authors.initials: C
authors.lastname: López-Aguilar
authors.forename: Julia
authors.initials: J
authors.lastname: Alcoba-Florez
authors.forename: Sebastián
authors.initials: S
authors.lastname: Méndez-Alvarez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D004196:Disease Outbreaks; D006801:Humans; D016106:Methicillin Resistance; D008969:Molecular Sequence Data; D016712:Mupirocin / Q000494:pharmacology*; D010957:Plasmids / Q000235:genetics; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D016712:Mupirocin