title: [Liver lesions in children with hepatitis B virus associated glomerulonephritis].
abstract: OBJECTIVE
  To investigate the pathological changes of liver in children with hepatitis B virus associated glomerulonephritis (HBV-GN).
  
  
  METHODS
  Thirteen children with HBV-GN (aged from 2-14 years) underwent renal and liver biopsy. The biopsy findings were analyzed.
  
  
  RESULTS
  Different degrees of hepatic lesions were seen in all of the 13 patients, mild lesions accounting for 69.2% (9/13). HBSAg positive was the most common in the liver tissue [76.9% (10/13)]. Among the renal lesions, membranous glomerulopathy accounted for 69.2%( 9/13), followed by membranoproliferative glomerulonephritis 30.8% (4/13). HBsAg and HBcAg positive were presented in all patients' kidney tissues. HBV antigens were detected in stroma between nephric tubule in all samples. Four patients presented with HBcAg positive in both live and kidneys.
  
  
  CONCLUSIONS
  The children with HBV-GN couple with liver lesions. The severity of the renal lesions is not always accord with that of the liver lesions. The appearance of HBcAg in both kidneys and liver indicates severe lesions of the two organs. It is suggested that a liver-kidney holistic treatment is necessary for children with HBV-GN.
authors.affiliation: Laboratory of Pediatric Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China. happydang@tom.com
authors.forename: Xi-Qiang
authors.initials: XQ
authors.lastname: Dang
authors.forename: Zhu-Wen
authors.initials: ZW
authors.lastname: Yi
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: He
authors.forename: Shuang-Hong
authors.initials: SH
authors.lastname: Mo
authors.forename: Zi-Chuan
authors.initials: ZC
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D006509:Hepatitis B / Q000150:complications* / Q000473:pathology; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008297:Male
chemical_list: D006512:Hepatitis B Core Antigens