N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.
A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to >200-fold.
Nie
Hong
H
GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
Widdowson
Katherine L
KL
Palovich
Michael R
MR
Fu
Wei
W
Elliott
John D
JD
Bryan
Deborah L
DL
Burman
Miriam
M
Schmidt
Dulcie B
DB
Foley
James J
JJ
Sarau
Henry M
HM
Busch-Petersen
Jakob
J
D006146:Guanidines / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D023062:Receptors, Interleukin-8A / Q000037:antagonists & inhibitors*; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors*
D006146:Guanidines; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B; C004711:dicyandiamido