[The possible pathogenesis of AA type amyloidosis in a patient with ulcerative colitis and renal cell carcinoma].
A 43-year-old male with a two-month history of ulcerative colitis and nephrectomy due to a renal cell carcinoma performed a month before was admitted to University Department of Nephrology for nephrotic syndrome and chronic renal failure. Biopsy of the remnant kidney revealed secondary AA amyloidosis with deposits in the glomeruli and walls of intrarenal blood vessels. Re-evaluation of the nephrectomized kidney also showed amyloid deposits both in the renal tissue free from malignant cells and in tumor tissue. In this case the amyloid deposition may have been the result of two coexisting disorders, ulcerative colitis and renal cell carcinoma, both known to be stimulators of amyloid deposition. The remnant kidney function worsened during the follow up and the patients started chronic dialysis after 6 months.
Kostadinova-Kunovska
Slavica
S
Institut za patologiju, Medicinski fakultet, Univerzitet, Sv Kiril i Metodij, Skopje, Makedonija.
Petrusevska
Gordana
G
Grcevska
Ladislava
L
Banev
Saso
S
Dzikova
Sonja
S
Bogoeva
Biljana
B
Polenaković
Momir
M
D000328:Adult; D000686:Amyloidosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000601:surgery; D003093:Colitis, Ulcerative / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications* / Q000601:surgery; D008297:Male; D000685:Serum Amyloid A Protein / Q000032:analysis
D000685:Serum Amyloid A Protein