A novel, antimicrobially active analog of gramicidin S without amphiphilic conformation.
A novel gramicidin S analog, cyclo(-Val-Leu-Leu-Orn-Leu-D-Phe-Pro-)2, was synthesized, its antibiotic activity compared with gramicidin S and shown to be as potent as gramicidin S when compared with the susceptibility toward five Gram-positive microorganisms. It exceeded the activity of gramicidin S against Bacillus megaterium ATCC 19213 by a factor of two. Circular dichroism and NMR data suggested this analog to adopt an antiparallel beta-sheet conformation without amphiphilic character.
Tamaki
Makoto
M
Sawa
Kenta
K
Kikuchi
Sho
S
Shindo
Mitsuno
M
Uchida
Yoshiki
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006096:Gramicidin / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D017433:Protein Structure, Secondary; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D006096:Gramicidin