Living donor liver transplantation for biliary atresia: a single-center experience with first 100 cases.
The aim of this study is to present our institutional experience in living donor liver transplantation (LDLT) as a treatment for end-stage liver disease in children with biliary atresia (BA). A retrospective review of transplant records was performed. One hundred BA patients (52 males and 48 females) underwent LDLT. The mean follow-up period was 85.5 months. The mean age was 2.4 years. The mean preoperative weight, height, and computed GFR were 12.2 kg, 82.5 cm, and 116.4 ml/min/1.73 m2, respectively. Twenty-seven patients were below 1 year of age, and 49 patients were below 10 kg at the time of transplantation. Ninety-six had had previous Kasai operation prior to transplant. The mean recipient operative time was 628 min. The mean recipient intraoperative blood loss was 176 ml. Thirty-five did not require blood or blood component transfusion. The left lateral segment (64) was the most common type of graft used. There were 27 operative complications which included 3 reoperations for postoperative bleeding, 9 portal vein, 4 hepatic vein, 4 hepatic artery, and 7 biliary complications. There was one in-hospital mortality and one retransplantation. The overall rejection rate was 20%. The overall mortality rate was 3%. The 6-month, 1-year and 5-year actual recipient survival rates were 99%, 98% and 98%, respectively.
Chen
C-L
CL
Liver Transplantation Program and Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan. clchen@adm.cgmh.org.tw
Concejero
A
A
Wang
C-C
CC
Wang
S-H
SH
Lin
C-C
CC
Liu
Y-W
YW
Yong
C-C
CC
Yang
C-H
CH
Lin
T-S
TS
Chiang
Y-C
YC
Jawan
B
B
Huang
T-L
TL
Cheng
Y-F
YF
Eng
H-L
HL
D001656:Biliary Atresia / Q000601:surgery*; D001835:Body Weight; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007223:Infant; D007677:Kidney Function Tests; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors; D008297:Male; D011183:Postoperative Complications / Q000145:classification; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome