title: Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats.
abstract: A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.
authors.affiliation: Departamento de Clínica Médica da Universidade Estadual de Campinas, FCM-UNICAMP, Campinas, São Paulo 13083-970, Brazil.
authors.forename: Patrícia Oliveira
authors.initials: PO
authors.lastname: Prada
authors.forename: José Rodrigo
authors.initials: JR
authors.lastname: Pauli
authors.forename: Eduardo Rochete
authors.initials: ER
authors.lastname: Ropelle
authors.forename: Henrique Gottardello
authors.initials: HG
authors.lastname: Zecchin
authors.forename: José Barreto Campello
authors.initials: JB
authors.lastname: Carvalheira
authors.forename: Lício Augusto
authors.initials: LA
authors.lastname: Velloso
authors.forename: Mario José Abdalla
authors.initials: MJ
authors.lastname: Saad
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D050722:Oncogene Protein v-cbl / Q000235:genetics / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D003598:Cytoskeletal Proteins; D004041:Dietary Fats; D007328:Insulin; D050722:Oncogene Protein v-cbl; D019869:Phosphatidylinositol 3-Kinases; D005947:Glucose