title: Sino-nasal bony and cartilaginous destruction associated with cocaine abuse, S. aureus and antineutrophil cytoplasmic antibodies.
abstract: Three male patients aged 29, 30 and 34 years and a 36-year-old female are reported with nasal septum perforation and a history of cocaine abuse. Two of the patients also had a perforation of the hard palate. In all four, antineutrophil cytoplasmic antibodies (ANCA) were found. One had a cytoplasmic immunofluorescence-staining pattern (c-ANCA), the other three showed a perinuclear staining pattern (p-ANCA). Furthermore, all patients were found to be nasal carriers of S. aureus. We hypothesise that tissue damage to the nasal and palatal area in patients using cocaine may partly be mediated by the presence of ANCA antibodies. Furthermore, we speculate that S. aureus facilitates the development of these ANCA antibodies.
authors.affiliation: Department of Endocrinology/Diabetes Centre, VU University Medical Centre, Amsterdam, the Netherlands. Simsek@vumc.nl
authors.forename: S
authors.initials: S
authors.lastname: Simsek
authors.forename: X H
authors.initials: XH
authors.lastname: de Vries
authors.forename: J A D
authors.initials: JA
authors.lastname: Jol
authors.forename: A M E
authors.initials: AM
authors.lastname: Spoelstra-de Man
authors.forename: P W B
authors.initials: PW
authors.lastname: Nanayakkara
authors.forename: Y M
authors.initials: YM
authors.lastname: Smulders
authors.forename: H F
authors.initials: HF
authors.lastname: Mahieu
authors.forename: P M
authors.initials: PM
authors.lastname: ter Wee
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D019970:Cocaine-Related Disorders / Q000150:complications* / Q000382:microbiology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000382:microbiology / Q000473:pathology*; D009297:Nasal Mucosa / Q000473:pathology; D009300:Nasal Septum / Q000382:microbiology / Q000473:pathology*; D009668:Nose Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic