Tumour surveillance in Beckwith-Wiedemann syndrome and hemihyperplasia: a critical review of the evidence and suggested guidelines for local practice.
There is strong evidence for an association between overgrowth disorders such as Beckwith-Wiedemann syndrome and the development of neoplasia. An increased cancer risk has also been observed in individuals with isolated hemihyperplasia. We critically review the evidence for tumour surveillance in Beckwith-Wiedemann syndrome and isolated hemihyperplasia and suggest local practice guidelines.
Tan
Tiong Y
TY
Genetic Health Services Victoria, Melbourne, Australia. tiong.tan@ghsv.org.au
Amor
David J
DJ
D000005:Abdomen / Q000000981:diagnostic imaging; D001506:Beckwith-Wiedemann Syndrome / Q000150:complications* / Q000235:genetics; D018197:Hepatoblastoma / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D006965:Hyperplasia / Q000235:genetics; D012306:Risk; D014463:Ultrasonography; D009396:Wilms Tumor / Q000175:diagnosis* / Q000209:etiology; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins