title: [Preventive treatment with topiramate enhances the quality of life of patients with migraine].
abstract: BACKGROUND
  Topiramate has recently proved to be safe and effective in the prevention of migraine and is currently the only neuromodulatory drug indicated for the prevention of migraine in Spain.
  
  
  OBJECTIVE
  To evaluate the adherence, effectiveness and safety of preventive treatment with topiramate in patients diagnosed with migraine.
  
  
  METHODS
  A prospective, observational, multi-centre study was conducted in general neurology departments. Patients eligible for the study were those with migraine, above 14 years of age, who needed preventive treatment and in whom other preventive treatments had failed or for whom topiramate was believed to be the most suitable therapy as regards its profile of side effects. The effectiveness of the treatment, patient satisfaction, side effects and loss of body weight were all evaluated. Effectiveness of the treatment was evaluated by means of the reduction in the frequency of migraines and the score obtained on the Headache Impact Test (HIT-6).
  
  
  RESULTS
  A total of 79 patients were evaluated. The dosage of topiramate ranged between 25 and 200 mg/day, with an average of 100 mg/day. 19% of the patients dropped out of the study due to side effects. Paresthesias were the most frequent reason for dropping out. No serious side effects were observed. 14% of the patients lost more than 5% of the base weight. The percentage of patients who responded was 58%. The degree of satisfaction of the patients who completed the follow-up was: good (80%), regular (11%) and poor (9%).
  
  
  CONCLUSIONS
  Preventive treatment with topiramate significantly reduces the impact of migraine and the disability that results from it. Treatment is satisfactory and improves the quality of life in a large percentage of patients.
authors.affiliation: Servico de Neurología. Hospital General de Elda, Elda, Alicante. vmedrano714k@cv.gva.es
authors.forename: V
authors.initials: V
authors.lastname: Medrano
authors.forename: A P
authors.initials: AP
authors.lastname: Sempere
authors.forename: J
authors.initials: J
authors.lastname: Morera-Guitart
authors.forename: S
authors.initials: S
authors.lastname: Fernandez-Izquierdo
authors.forename: J
authors.initials: J
authors.lastname: Espinosa-Martinez
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D017060:Patient Satisfaction; D011446:Prospective Studies; D011788:Quality of Life; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose