title: Genetic interactions between Drosophila melanogaster menin and Jun/Fos.
abstract: Menin is a tumor suppressor required to prevent multiple endocrine neoplasia in humans. Mammalian menin protein is associated with chromatin modifying complexes and has been shown to bind a number of nuclear proteins, including the transcription factor JunD. Menin shows bidirectional effects acting positively on c-Jun and negatively on JunD. We have produced protein null alleles of Drosophila menin (mnn1) and have over expressed the Mnn1 protein. Flies homozygous for protein-null mnn1 alleles are viable and fertile. Localized over-expression of Mnn1 causes defects in thoracic closure, a phenotype that sometimes results from insufficient Jun activity. We observed complex genetic interactions between mnn1 and jun in different developmental settings. Our data support the idea that one function of menin is to modulate Jun activity in a manner dependent on the cellular context.
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, Department of Health and Human Services, Bethesda, MD 20892, USA. a.cerrato@sun.ceos.na.cnr.it
authors.forename: Aniello
authors.initials: A
authors.lastname: Cerrato
authors.forename: Michael
authors.initials: M
authors.lastname: Parisi
authors.forename: Sonia
authors.initials: S
authors.lastname: Santa Anna
authors.forename: Fanis
authors.initials: F
authors.lastname: Missirlis
authors.forename: Siradanahalli
authors.initials: S
authors.lastname: Guru
authors.forename: Sunita
authors.initials: S
authors.lastname: Agarwal
authors.forename: David
authors.initials: D
authors.lastname: Sturgill
authors.forename: Thomas
authors.initials: T
authors.lastname: Talbot
authors.forename: Allen
authors.initials: A
authors.lastname: Spiegel
authors.forename: Francis
authors.initials: F
authors.lastname: Collins
authors.forename: Settara
authors.initials: S
authors.lastname: Chandrasekharappa
authors.forename: Stephen
authors.initials: S
authors.lastname: Marx
authors.forename: Brian
authors.initials: B
authors.lastname: Oliver
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics; D005123:Eye / Q000033:anatomy & histology / Q000196:embryology; D008969:Molecular Sequence Data; D010641:Phenotype; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics* / Q000502:physiology; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics* / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D013909:Thorax / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; C499857:Mnn1 protein, Drosophila; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun