title: Multivariate analysis of the selected metals in the hair of cerebral palsy patients versus controls.
abstract: Seventeen metals were measured in scalp hair samples from cerebral palsy patients (CPPs) and controls. Samples were collected from 95 CPPs and 93 controls. The nitric acid-perchloric acid wet digestion procedure was used for quantification of the selected metals by flame atomic absorption spectrophotometry. The concentrations of Ag, Ca, Cd, Co, Cr, Li, and Mg were significantly higher and those of Cu, Fe, K, Mn, Na, Ni, Pb, and Sb were lower in the hair of CPPs compared with controls. Astrong positive correlation was found between Ca and Mg in the hair of controls but not in that of CPPs. Antimony was found significantly negative in terms of its correlation with Co and Cu in CPPs group but not in the controls. Principal component analysis (PCA) of the data extracted seven factors for CPPs and six factors for controls. Cluster analysis (CA) was also used to support the PCA results. The study evidenced some specific source of Mg and Sb in the hair of CPPs.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Khalique
authors.forename: Munir H
authors.initials: MH
authors.lastname: Shah
authors.forename: M
authors.initials: M
authors.lastname: Jaffar
authors.forename: N
authors.initials: N
authors.lastname: Shaheen
authors.forename: Saadia R
authors.initials: SR
authors.lastname: Tariq
authors.forename: S
authors.initials: S
authors.lastname: Manzoor
mesh_terms: D000293:Adolescent; D000328:Adult; D002547:Cerebral Palsy / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006197:Hair / Q000378:metabolism*; D006801:Humans; D008297:Male; D008670:Metals / Q000378:metabolism*; D015999:Multivariate Analysis; D014131:Trace Elements / Q000378:metabolism
chemical_list: D008670:Metals; D014131:Trace Elements