Endothelial dysfunction in cold type complex regional pain syndrome.
The authors examined endothelial function in cold type chronic complex regional pain syndrome (CRPS) I using acetylcholine- and sodium nitroprusside-induced vasodilation combined with laser Doppler flowmetry in 14 patients and 10 controls. On the affected side, acetylcholine-induced vasodilation was significantly reduced in comparison to controls and the unaffected extremity. No significant differences were found after application of sodium nitroprusside. The results demonstrate impaired endothelial function in chronic CRPS I.
Schattschneider
J
J
Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany. j.schattschneider@neurologie.uni-kiel.de
Hartung
K
K
Stengel
M
M
Ludwig
J
J
Binder
A
A
Wasner
G
G
Baron
R
R
D000109:Acetylcholine; D000328:Adult; D000368:Aged; D003080:Cold Temperature; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000187:drug effects*; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000000981:diagnostic imaging*; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside; D012019:Reflex Sympathetic Dystrophy / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D014652:Vascular Diseases / Q000000981:diagnostic imaging*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D009599:Nitroprusside; D000109:Acetylcholine