Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells.
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL- mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.
Kwon
Daeho
D
Department of Microbiology, Ajou University College of Medicine, Seoul, Korea.
Choi
In-Hong
IH
D000486:Allergy and Immunology; D017209:Apoptosis; D001253:Astrocytes / Q000378:metabolism*; D045744:Cell Line, Tumor; D016572:Cyclosporine / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D000860:Hypoxia; D007166:Immunosuppressive Agents / Q000494:pharmacology; D018384:Oxidative Stress; D012260:Ribonucleases / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000096:biosynthesis*; D015854:Up-Regulation
D007166:Immunosuppressive Agents; D053221:TNF-Related Apoptosis-Inducing Ligand; D016572:Cyclosporine; D006861:Hydrogen Peroxide; D012260:Ribonucleases