MMM: a sequence-to-structure alignment protocol.
BACKGROUND
Accurate alignment of a target sequence to a template structure continues to be a bottleneck in producing good quality comparative protein structure models.


RESULTS
Multiple Mapping Method (MMM) is a comparative protein structure modeling server with an emphasis on a novel alignment optimization protocol. MMM takes inputs from five profile-to-profile based alignment methods. The alternatively aligned regions from the input alignment set are combined according to their fit in the structural environment of the template structure. The resulting, optimally spliced MMM alignment is used as input to an automated comparative modeling module to produce a full atom model.


BACKGROUND
The MMM server is freely accessible at http://www.fiserlab.org/servers/mmm
Rai
Brajesh K
BK
Department of Biochemistry and Seaver Center for Bioinformatics, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Madrid-Aliste
Carlos J
CJ
Fajardo
J Eduardo
JE
Fiser
András
A
D000465:Algorithms; D000595:Amino Acid Sequence; D003198:Computer Simulation; D020407:Internet; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software