Enzymatic gluten detoxification: the proof of the pudding is in the eating!
Celiac disease is caused by an immune response to the dietary protein gluten. The only available treatment is the strict exclusion of gluten from the diet; however, this is marred by the virtual omnipresence of this protein. The enzymatic degradation of gluten might become an alternative to the gluten-free diet, and recent work indicates that such approaches are getting close to being tested in clinical trials.
Stepniak
Dariusz
D
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Koning
Frits
F
D001711:Biotransformation / Q000502:physiology; D002446:Celiac Disease / Q000178:diet therapy* / Q000503:physiopathology; D003546:Cysteine Endopeptidases / Q000008:administration & dosage / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D019587:Dietary Supplements; D005983:Glutens / Q000378:metabolism*; D006801:Humans; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000008:administration & dosage / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000494:pharmacology*
D005983:Glutens; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases; D003546:Cysteine Endopeptidases