title: H9N2 influenza viruses isolated from poultry in Korean live bird markets continuously evolve and cause the severe clinical signs in layers.
abstract: H9N2 influenza viruses are endemic in many Asian countries. We demonstrated that H9N2 influenza viruses isolated from poultry in Korean live bird markets are genetically changing and could cause the clinical signs in layers. Genetic analysis showed that Korean avian H9N2 influenza viruses are distinct from H9N2 influenza viruses circulating in poultry in China and Hong Kong. When we infected layers with H9N2 isolates, layers showed about 30% mortality and the reduction of egg productions. Considering that H9N2 influenza virus is one of potential pandemic candidates, the continuous surveillance is needed to monitor avian H9N2 influenza viruses for the poultry industry and humans.
authors.affiliation: College of Veterinary Medicine, Chungnam National University, Yuseong-Gu, Daejeon, South Korea.
authors.forename: Jin A
authors.initials: JA
authors.lastname: Kim
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Cho
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Sang Heui
authors.initials: SH
authors.lastname: Seo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002645:Chickens; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D053127:Influenza A Virus, H9N2 Subtype / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D005585:Influenza in Birds / Q000473:pathology / Q000821:virology*; D007723:Korea; D007928:Lethal Dose 50; D010058:Oviposition; D010802:Phylogeny; D011201:Poultry Diseases / Q000473:pathology / Q000821:virology*; D018571:Sentinel Surveillance / Q000662:veterinary; D017385:Sequence Homology; D014779:Virus Replication