title: In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis.
abstract: The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of Nocardia brasiliensis and Mycobacterium tuberculosis were determined. Equal MIC(50)s and MIC(90)s (0.25 and 0.5 microg/ml, respectively) were found for susceptible and multidrug-resistant isolates of M. tuberculosis. The N. brasiliensis isolates showed an MIC(90) of 1 microg/ml and an MIC(50) of 1 microg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for M. tuberculosis but fivefold-higher MICs for N. brasiliensis.
authors.affiliation: Servicio de Dermatología, Hospital Universitario José E. González, Monterrey, N.L., México. luvera_99@yahoo.com
authors.forename: Lucio
authors.initials: L
authors.lastname: Vera-Cabrera
authors.forename: Eva
authors.initials: E
authors.lastname: Gonzalez
authors.forename: Adrian
authors.initials: A
authors.lastname: Rendon
authors.forename: Jorge
authors.initials: J
authors.lastname: Ocampo-Candiani
authors.forename: Oliverio
authors.initials: O
authors.lastname: Welsh
authors.forename: Victor M
authors.initials: VM
authors.lastname: Velazquez-Moreno
authors.forename: Sung Hak
authors.initials: SH
authors.lastname: Choi
authors.forename: Carmen
authors.initials: C
authors.lastname: Molina-Torres
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D009615:Nocardia / Q000187:drug effects* / Q000302:isolation & purification; D010755:Organophosphates / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones / Q000494:pharmacology*; D011355:Prodrugs / Q000494:pharmacology*; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; C515039:DA 7157; D010755:Organophosphates; D010080:Oxazoles; D023303:Oxazolidinones; D011355:Prodrugs; D013777:Tetrazoles; C515040:tedizolid phosphate