title: Association of serum lipids with diabetic retinopathy in urban South Indians--the Chennai Urban Rural Epidemiology Study (CURES) Eye Study--2.
abstract: OBJECTIVE
  To study the association of serum lipids with diabetic retinopathy (DR) in Type 2 diabetic subjects.
  
  
  METHODS
  Type 2 diabetic subjects (n = 1736) were randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), which was carried out on a representative population of Chennai in South India. DR was diagnosed by retinal colour photography and classified according to the Early Treatment Diabetic Retinopathy Study (ETDRS) grading system. Classification of lipid abnormalities was done according to the National Cholesterol Education Programme-Adult Treatment Panel III (NCEP-ATP III) Guidelines.
  
  
  RESULTS
  The mean serum cholesterol (P = 0.024), serum triglycerides (P = 0.017) and non-high-density lipoprotein (HDL)-cholesterol (P = 0.025) concentrations were higher in subjects with DR compared with those without DR. Multiple logistic regression analysis revealed that after adjusting for age, gender, duration of diabetes, total cholesterol Standardised regression estimate (SRE) = 1.178, 95% confidence interval (CI) 1.042, 1.331, P = 0.014), non-HDL-cholesterol (SRE = 1.169, 95% CI 1.040, 1.313, P = 0.012) and serum triglycerides (SRE = 1.292, 95% CI 1.136, 1.467, P = 0.001) were associated with DR and non-HDL-cholesterol (SRE = 1.264, 95% CI 1.000, 1.592, P = 0.045) and low-density lipoprotein (LDL)-cholesterol (SRE = 1.453, 95% CI 1.107, 1.896, P = 0.005) with diabetic macular oedema (DME). After adjusting for HbA(1c) and body mass index, only triglycerides maintained a significant association with DR (SRE = 1.137, 95% CI 1.000, 1.291, P = 0.007) and LDL-cholesterol with macular oedema (SRE = 1.358, 95% CI 1.034, 1.774, P = 0.026).
  
  
  CONCLUSIONS
  There is a significant association of serum triglycerides with DR and LDL-cholesterol with DME.
authors.affiliation: Madras Diabetes Research Foundation & Dr Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai, India. drrema@vsnl.com
authors.forename: M
authors.initials: M
authors.lastname: Rema
authors.forename: B K
authors.initials: BK
authors.lastname: Srivastava
authors.forename: B
authors.initials: B
authors.lastname: Anitha
authors.forename: R
authors.initials: R
authors.lastname: Deepa
authors.forename: V
authors.initials: V
authors.lastname: Mohan
mesh_terms: D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008269:Macular Edema / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood; D014504:Urban Health / Q000706:statistics & numerical data; D014792:Visual Acuity
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides