title: [Toxic epidermal necrolysis].
abstract: Toxic epidermal necrolysis (TEN) is a rare, mostly drug-induced life-threatening mucocutaneous reaction with generalised symptoms and internal organ involvement. Current treatment strategy focuses on supportive intensive care with close collaboration among many specialties. Specific therapies for TEN have not yet reached evidence-based levels of acceptance. The clinical syndrome, diagnostic criteria, pathogenesis and possible disease-limiting drug therapy are discussed.
authors.affiliation: Odense Universitetshospital, Dermato-venerologisk Afdeling I, Odense C. anette.bygum@ouh.fyns-amt.dk
authors.forename: Anette
authors.initials: A
authors.lastname: Bygum
authors.forename: Klaus Ejner
authors.initials: KE
authors.lastname: Andersen
mesh_terms: D003422:Critical Care / Q000379:methods; D006801:Humans; D033183:Interdisciplinary Communication; D008991:Monitoring, Physiologic; D010347:Patient Care Planning; D011379:Prognosis; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology / Q000473:pathology