Unified total syntheses of the inositol polyphosphates: D-I-3,5,6P3, D-I-3,4,5P3, D-I-3,4,6P3, and D-I-3,4,5,6P4 via catalytic enantioselective and site-selective phosphorylation.
Synthetic routes to various inositol polyphosphates have been discovered utilizing catalytic enantioselective and site-selective phosphorylation reactions. The syntheses described herein exploit a common intermediate to gain efficient access to eight unique inositol polyphosphates.
Morgan
Adam J
AJ
Department of Chemistry, Boston College, Chestnut Hill, MA 02467, USA.
Komiya
Shio
S
Xu
Yingju
Y
Miller
Scott J
SJ
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D007295:Inositol Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D010766:Phosphorylation; D011122:Polyphosphates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D007295:Inositol Phosphates; D011122:Polyphosphates; C118500:inositol 3,4,5-trisphosphate; C081652:inositol-3,4,5,6-tetrakisphosphate