Studies of chronic ITP in children and adolescents.
This paper presents an ongoing study of children with chronic ITP in Sweden that addresses four specific questions: is there a subgroup of children with chronic ITP that have impaired platelet function? Do children in this subgroup have antibodies directed against surface glycoproteins that are crucial for platelet function? Can desmopressin improve the impaired platelet function in this subgroup? Do children with chronic ITP show signs of cell-mediated cytotoxicity?
Nilsson
Cecilia
C
Department of Clinical Sciences Malmö, Research Unit for Pediatric Hematology, Medical Faculty, University of Lund at Pediatric Clinic, University Hospital Malmö, Malmö, Sweden.
Tedgård
Ulf
U
Ljung
Rolf
R
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology; D002648:Child; D002908:Chronic Disease; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D008562:Membrane Glycoproteins / Q000276:immunology; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D013548:Sweden / Q000453:epidemiology
D001323:Autoantibodies; D008562:Membrane Glycoproteins; D003894:Deamino Arginine Vasopressin