title: Studies of chronic ITP in children and adolescents.
abstract: This paper presents an ongoing study of children with chronic ITP in Sweden that addresses four specific questions: is there a subgroup of children with chronic ITP that have impaired platelet function? Do children in this subgroup have antibodies directed against surface glycoproteins that are crucial for platelet function? Can desmopressin improve the impaired platelet function in this subgroup? Do children with chronic ITP show signs of cell-mediated cytotoxicity?
authors.affiliation: Department of Clinical Sciences Malmö, Research Unit for Pediatric Hematology, Medical Faculty, University of Lund at Pediatric Clinic, University Hospital Malmö, Malmö, Sweden.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Nilsson
authors.forename: Ulf
authors.initials: U
authors.lastname: Tedgård
authors.forename: Rolf
authors.initials: R
authors.lastname: Ljung
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology; D002648:Child; D002908:Chronic Disease; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D008562:Membrane Glycoproteins / Q000276:immunology; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D013548:Sweden / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D008562:Membrane Glycoproteins; D003894:Deamino Arginine Vasopressin