New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula.
BACKGROUND
Choledochoduodenal fistula (CDF) is a complication of common bile duct stones or cholangitis in Asia. It is unclear as to which type of the fistula needs surgical treatment.


METHODS
To determine whether the sizes of CDF imply different clinical presentations and treatments, we reviewed 50 patients with CDF and their treatments during a recent 14-year period. For treatments of CDF, we applied the conventional methods, including removal of stone and complete decompression of biliary obstruction to treat the original bile lesions. In addition, according to the sizes of fistula and the frequencies of ascending cholangitis, we proposed the following strategies for fistula treatments: (i) for fistula orifices larger than 1 cm, a transection of common bile duct was applied to prevent the reflux of duodenal juice; (ii) for fistula orifices between 0.5 and 1.0 cm, an effective biliary drainage was applied; and (iii) for fistula orifices less than 0.5 cm, non-surgical treatments were applied.


RESULTS
We found that hepatic biliary duct stones and hepatic biliary duct strictures were associated with more severe cholangitis (P = 0.037 and P = 0.009, respectively), but not with the episodes of cholangitis (P = 0.654 and P = 0.664, respectively). In contrast, the sizes of fistula >1 cm were associated with more frequent episodes of cholangitis (r = 0.774; P < 0.001).


CONCLUSIONS
The larger fistula increases frequency of cholangitis episodes and needs surgical treatment for fistula itself.
Li
Zhi-Hua
ZH
Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China.
Ding
Jun
J
Ye
Yongqian
Y
Cai
Lei
L
Liu
Xiangde
X
Liu
Jikui
J
Chen
Ming
M
Li
Xiaowu
X
Dong
Jiahong
J
D001649:Bile Duct Diseases / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D001658:Biliary Fistula / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D002761:Cholangitis / Q000150:complications / Q000517:prevention & control*; D004378:Duodenal Diseases / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007412:Intestinal Fistula / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged