The role of antibody affinity for specific antigens in the differential diagnosis of inflammatory nervous system disorders.
Affinity maturation has previously been shown with assays for total IgG for specific antigens using the technique of competition by chaotropic ions. We have extended this technique to individual clones and followed the maturation of clones during the course of herpes encephalitis. This has important implications for our understanding of the pathogenesis of multiple sclerosis.
Giovannoni
Gavin
G
Department of Neuroimmunology, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Chapman
Miles D
MD
Thompson
Edward J
EJ
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D000918:Antibody Specificity / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000737:chemistry / Q000276:immunology*; D003937:Diagnosis, Differential; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry / Q000276:immunology; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology
D000941:Antigens; D001323:Autoantibodies; D000939:Epitopes; D007074:Immunoglobulin G