[Papillomavirus and factors associated with high-risk, cervical intraepithelial neoplasia in Cauca, Colombia].
OBJECTIVE
Evaluating the role of the main factors associated with high-risk cervical intraepithelial neoplasia in women from the Cauca Department in Colombia.


METHODS
After signing a consent-form, women were interviewed to obtain socio-demographic and lifestyle data. A cervical biopsy was performed on each woman for histopathological diagnosis (cases) and a sample of exfoliated cells (cases and controls) to extract DNA for HPV detection by polymerase chain reaction. A total of 98 cases and 109 controls, matched by age and ethnicity, were recruited for the study.


RESULTS
The study confirmed association between HPV and the risk of cervical neoplasia (OR = 19.0; 95% CI = 8.20-44.2). The data suggested that multiparity (OR = 4.1; 95% CI = 1.62-10.6) and exposure to carcinogens present in wood-smoke (OR = 7.3; 95% CI = 3.00-19.4) are important co-factors for cervical neoplasia given the presence of HPV.


CONCLUSIONS
These results provide valuable information for public health institutions to develop better cervical neoplasia prevention programmes.
Sierra-Torres
Carlos H
CH
Departamento de Ciencias Fisiológicas, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia. hsierra@unicauca.edu.co
Acosta-Aragón
Maria P
MP
Orejuela-Aristizabal
Leonora
L
D000293:Adolescent; D000328:Adult; D016902:Air Pollution, Indoor / Q000706:statistics & numerical data; D016022:Case-Control Studies; D003105:Colombia / Q000453:epidemiology; D003278:Contraceptives, Oral, Hormonal; D015344:DNA Probes, HPV; D004363:Drug Utilization; D005260:Female; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D010298:Parity; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D012906:Smoke; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology; D014934:Wood; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000821:virology
D003278:Contraceptives, Oral, Hormonal; D015344:DNA Probes, HPV; D012906:Smoke