title: An improved 62Zn/62Cu generator based on a cation exchanger and its fully remote-controlled preparation for clinical use.
abstract: OBJECTIVE
  The goal of this study was to develop an improved (62)Zn/(62)Cu generator based on cation exchange resin and remote preparation at high radioactivity scale for clinical use.
  
  
  METHODS
  A natural Cu target was irradiated with proton beam in the energy range of 30-->19 MeV at a beam current of 10 muA for 1 h to obtain around 1.7 GBq of (62)Zn. The (62)Zn was isolated from the Cu target on an anion exchange column with more than 97% yield within 2.5 h from the EOB. The (62)Zn/(62)Cu generator was prepared by loading the (62)Zn(2+) on a Sep-Pak plus CM cartridge.
  
  
  RESULTS
  The generator showed high elution efficiency ( approximately 96%) using a small volume (ca. 3 ml) of a 200-mM glycine solution with a very low breakthrough of (62)Zn (<0.1%).
  
  
  CONCLUSIONS
  This (62)Zn/(62)Cu generator has been proven to be highly useful as a source of (62)Cu for the synthesis of (62)Cu-labeled compounds. The clinical application of [(62)Cu]Cu-ATSM produced with this generator has been already approved by the Institutional Review Board at the National Institute of Radiological Sciences.
authors.affiliation: Department of Medical Imaging, Radiopharmaceutical Chemistry Section, National Institute of Radiological Sciences, Chiba 263-8555, Japan. t_fukumu@nirs.go.jp
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Fukumura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okada
authors.forename: Hisashi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakao
authors.forename: Kensaku
authors.initials: K
authors.lastname: Mukai
authors.forename: Ferenc
authors.initials: F
authors.lastname: Szelecsényi
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Kovács
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D002411:Cation Exchange Resins; D003301:Copper Radioisotopes; D006801:Humans; D009942:Organometallic Compounds; D011786:Quality Control; D011876:Radionuclide Generators / Q000592:standards; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones; D014055:Tomography, Emission-Computed; D015037:Zinc Radioisotopes
chemical_list: D002411:Cation Exchange Resins; D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones; D015037:Zinc Radioisotopes; C052629:copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex