title: Thallium-201 myocardial SPECT in left bundle branch block: diagnosis of myocardial ischemia with a disease-specific reference database.
abstract: BACKGROUND
  The aim of this study was to assess the value of a myocardial perfusion single photon emission computed tomography (SPECT) reference file for patients with left bundle branch block (LBBB).
  
  
  RESULTS
  Tl-201 stress-redistribution myocardial perfusion SPECT studies of patients with complete, permanent LBBB were reviewed retrospectively. To develop a reference database, 18 patients with a low likelihood of coronary artery disease (CAD) were selected. Left ventricular regional average and standard deviation (SD) values of the reference file images were calculated. The diagnostic performance was tested on perfusion images of 49 patients with LBBB, undergoing both scintigraphic and coronary angiographic evaluation, and was compared with a commercial quantitative analysis system using a general reference database. The LBBB reference file performed significantly better in detecting epicardial CAD than did the general reference database (receiver operating characteristic area under the curve 0.835 +/- 0.06 vs 0.580 +/- 0.08, p < .01). Disease localization also was improved significantly in the territory of the left anterior descending and of the right coronary arteries.
  
  
  CONCLUSIONS
  The use of a reference file of patients with LBBB and a low likelihood of CAD aids the detection and the localization of myocardial ischemia on Tl-201 myocardial SPECT images of this patient group.
authors.affiliation: Department of Cardiology, Semmelweis University, Budapest, Hungary. zkristof@freemail.hu
authors.forename: Kristóf
authors.initials: K
authors.lastname: Zupán
authors.forename: Béla
authors.initials: B
authors.lastname: Kári
authors.forename: Géza
authors.initials: G
authors.lastname: Fontos
authors.forename: Péter
authors.initials: P
authors.lastname: Dékány
authors.forename: Oszkár
authors.initials: O
authors.lastname: Pártos
mesh_terms: D002037:Bundle-Branch Block / Q000150:complications / Q000000981:diagnostic imaging*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology; D019275:Radiopharmaceuticals; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology
chemical_list: D019275:Radiopharmaceuticals; C027549:thallium chloride; D013793:Thallium