The role of electrostatics in protein-membrane interactions.
Many experimental, structural and computational studies have established the importance of nonspecific electrostatics as a driving force for peripheral membrane association. Here we focus on this component of protein/membrane interactions by using examples ranging from phosphoinositide signaling to retroviral assembly. We stress the utility of the collaboration of experiment and theory in identifying and quantifying the role of electrostatics not only in contributing to membrane association, but also in affecting subcellular targeting, in the control of membrane binding, and in the organization of proteins and lipids at membrane surfaces.
Mulgrew-Nesbitt
Anna
A
Weill Medical College of Cornell University, New York, NY 10021, USA.
Diraviyam
Karthikeyan
K
Wang
Jiyao
J
Singh
Shaneen
S
Murray
Paul
P
Li
Zhaohui
Z
Rogers
Laura
L
Mirkovic
Nebojsa
N
Murray
Diana
D
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D003198:Computer Simulation; D005971:Glutamates / Q000737:chemistry; D006801:Humans; D008024:Ligands; D008563:Membrane Lipids / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D010716:Phosphatidylinositols / Q000737:chemistry / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011522:Protons; D012190:Retroviridae / Q000502:physiology; D015398:Signal Transduction; D055672:Static Electricity; D019065:Virus Assembly
D005971:Glutamates; D008024:Ligands; D008563:Membrane Lipids; D010716:Phosphatidylinositols; D011522:Protons