title: Hypocrellin D, a cytotoxic fungal pigment from fruiting bodies of the ascomycete Shiraia bambusicola.
abstract: A fungal pigment, hypocrellin D (1), together with three known perylenequinone derivatives hypocrellin A (2), B (3) and C (4), was isolated from the fruiting bodies of Shiraia bambusicola. Its structure was elucidated on the basis of spectral data including 2D NMR experiments. Hypocrellin D (1) significantly inhibited the growth of tumor cell lines Bel-7721, A-549 and Anip-973 with IC50 values of 1.8, 8.8, 38.4 microg/ml, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, Chinese Academy of Sciences.
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Fang
authors.forename: Chen
authors.initials: C
authors.lastname: Qing
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Shao
authors.forename: Yi-Dong
authors.initials: YD
authors.lastname: Yang
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Wan-Qiu
authors.initials: WQ
authors.lastname: Yang
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D010860:Pigments, Biological; C513064:hypocrellin D; D010569:Perylene