title: 1 kHz tabletop ultrashort hard x-ray source for time-resolved x-ray protein crystallography.
abstract: We describe a compact, reliable, and high-average-power femtosecond x-ray source and its first application to diffraction on protein crystal. The setup relies on a homemade Ti: sapphire system delivering 12 mJ at a 1 kHz repetition rate, associated with a small vacuum chamber especially designed for laser-plasma interaction and x-ray applications. This device allows the generation of 5 x 10(9) photons/s/sr at 8 keV and optimized x-ray irradiation of the studied sample, which can be placed close to the source. We present the diffraction pattern of a protein crystal in a divergent beam geometry, which is a first step to a subpicosecond x-ray diffraction experiment.
authors.affiliation: Laboratoire d'Optique et Biosciences CNRS UMR 7645--INSERM U699--Ecole Polytechnique, Palaiseau Cedex, France. adeline.bonvalet@polytechnique.fr
authors.forename: Adeline
authors.initials: A
authors.lastname: Bonvalet
authors.forename: Adeline
authors.initials: A
authors.lastname: Darmon
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Lambry
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Martin
authors.forename: Patrick
authors.initials: P
authors.lastname: Audebert
mesh_terms: D018360:Crystallography, X-Ray / Q000295:instrumentation / Q000379:methods; D009113:Muramidase / Q000737:chemistry*
chemical_list: D009113:Muramidase