[Effects of green tea polyphenol on the behaviour of Alzheimer' s disease like mice induced by D-galactose and Abeta25-35].
OBJECTIVE
To study the effects of green tea polyphenol (GTP) on the behaviour of Alzheimer' s Disease like mice induced by D-galactose and Abeta25-35.


METHODS
D-galactose (120 mg/kg) was intraperitoneally injected into mice for 12 weeks and Abeta25-35 (4nmol) was injected by icv to establish Alzheimer' s Disease like mice. The protective and therapeutic effects of GTP were determined by using water maze test, step down test, step through test and open field test.


RESULTS
GTP ameliorated the deleterious effects of D-galactose and Abeta25-35, and thereby improved the animal' s learning and memory, prolonged latency time, and the error numbers were significantly reduced. At the same time the autonomic activities were significantly increased.


CONCLUSIONS
GTP can improve the behaviour of Alzheimer' s Disease like mice induced by D-galactose and Abeta25-35.
Lü
Jun-Hua
JH
Department of Pharmacology, Jinan University Pharmacy College, Guangzhou 510632, China.
Guo
Jing
J
Yang
Wen-Hao
WH
D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D016229:Amyloid beta-Peptides; D000818:Animals; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005690:Galactose; D006624:Hippocampus / Q000187:drug effects; D007859:Learning Disabilities / Q000188:drug therapy; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D059808:Polyphenols; D013662:Tea / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D005419:Flavonoids; D018696:Neuroprotective Agents; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013662:Tea; D005690:Galactose