Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats.
A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.
Prada
Patrícia Oliveira
PO
Departamento de Clínica Médica da Universidade Estadual de Campinas, FCM-UNICAMP, Campinas, São Paulo 13083-970, Brazil.
Pauli
José Rodrigo
JR
Ropelle
Eduardo Rochete
ER
Zecchin
Henrique Gottardello
HG
Carvalheira
José Barreto Campello
JB
Velloso
Lício Augusto
LA
Saad
Mario José Abdalla
MJ
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D050722:Oncogene Protein v-cbl / Q000235:genetics / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000502:physiology*
D003598:Cytoskeletal Proteins; D004041:Dietary Fats; D007328:Insulin; D050722:Oncogene Protein v-cbl; D019869:Phosphatidylinositol 3-Kinases; D005947:Glucose