title: [A comparative study of choroidal innervation in the human and the rabbit (oryctolagus cuniculus)].
abstract: OBJECTIVE
  To analyze morphological differences between the choroidal innervation of the human and the rabbit, the latter being a species frequently used as an experimental model of human ocular diseases.
  
  
  METHODS
  Twelve human and 12 rabbit choroidal whole mounts were processed using an indirect immunohistochemical technique, peroxidase-anti-peroxidase and antibodies against 200 kD neurofilament.
  
  
  RESULTS
  Choroidal nerve fibers were perivascular and intervascular. Perivascular fibers surrounded all arteries forming a network that was more developed in the rabbit. In humans, intervascular fibers were mainly concentrated at the posterior pole where they formed a denser and more highly organized plexus than in the rabbit, which did not exhibit a preferential location for these fibers. Human choroidal ganglion cells were far more numerous than in the rabbit and were concentrated in a circumferential area corresponding to the entrance of the short posterior ciliary arteries of the submacular area. In the rabbit, these cells were restricted to the peripheral choroid.
  
  
  CONCLUSIONS
  Some differences were observed between human and rabbit choroidal innervation. The abundance of ganglion cells and their preferential distribution could be necessary to maintain a constant blood flow in the central area of the human choroid. The lack of organization of rabbit choroidal innervation at the posterior pole could be associated with an absence of the macula. These differences, along with peculiarities of retinal vascularization, should be taken into consideration when using the rabbit as an experimental model to study human eye diseases in which regulation of choroidal blood flow is involved.
authors.affiliation: Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, España.
authors.forename: R
authors.initials: R
authors.lastname: de Hoz
authors.forename: J J
authors.initials: JJ
authors.lastname: Salazar
authors.forename: A I
authors.initials: AI
authors.lastname: Ramírez
authors.forename: B
authors.initials: B
authors.lastname: Rojas
authors.forename: A
authors.initials: A
authors.lastname: Triviño
authors.forename: J M
authors.initials: JM
authors.lastname: Ramírez
mesh_terms: D000818:Animals; D002829:Choroid / Q000294:innervation*; D006801:Humans; D011817:Rabbits