title: Effects of dietary supplementation of DL-methionine or 2-hydroxy-4-(methylthio)-butanoic acid on food intake, nutrient digestibility, nitrogen balance, and urinary and blood metabolites in healthy, growing dogs.
abstract: The aim of this study was to evaluate effects on nutritional responses of supplemental DL-methionine and 2-hydroxy-4-(methylthio) butanoic acid (HMTBA) in a commercial-type diet in growing dogs. A nitrogen balance study was conducted as a randomized complete block design using 30 Pointer puppies (72-d-old; 5.5 kg). A corn and poultry byproduct meal based diet was supplemented with 0.1 or 0.2% DL-methionine or HMTBA on an equimolar basis. Organic matter and gross energy tended (p < 0.10) to be less digestible by dogs fed the 0.1% HMTBA diet compared with the 0.2% DL-methionine diet, but other nutrients were unaffected. Postprandial urinary calcium tended (p < 0.10) to be lower for the basal and HMTBA treatments. Fecal ammonia tended (p < 0.10) to be lower for the 0.1% HMTBA diet than for the 0.2% DL-methionine diet. At the levels tested, DL-methionine and HMTBA appear to act similarly when included in a corn and poultry by-product meal diet fed to young dogs.
authors.affiliation: Department of Animal Sciences, University of Illinois, Urbana 61801, USA.
authors.forename: Ingmar S
authors.initials: IS
authors.lastname: Middelbos
authors.forename: Lisa K
authors.initials: LK
authors.lastname: Karr-Lilienthal
authors.forename: Juliana
authors.initials: J
authors.lastname: Folador
authors.forename: Mercedes
authors.initials: M
authors.lastname: Vazquez-Anon
authors.forename: Ganfeng
authors.initials: G
authors.lastname: Yi
authors.forename: George C
authors.initials: GC
authors.lastname: Fahey
mesh_terms: D000641:Ammonia / Q000032:analysis; D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001806:Blood Urea Nitrogen; D002118:Calcium / Q000652:urine; D019587:Dietary Supplements; D004063:Digestion / Q000187:drug effects*; D004285:Dogs / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects*; D005243:Feces / Q000737:chemistry; D008715:Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009584:Nitrogen / Q000378:metabolism*; D011897:Random Allocation
chemical_list: C008391:alpha-hydroxy-gamma-methylmercaptobutyric acid; D000641:Ammonia; D008715:Methionine; D009584:Nitrogen; D002118:Calcium