title: [McCune-Albright syndrome: a difficult and complicated case study].
abstract: McCune-Albright syndrome is a rare G proteins alpha disorder. The disorder is characterized by polyostotic fibrous dysplasia, sexual precocity and hyperpigmented macules. It is caused due to mutations in the gene Gsalpha that incodes the alpha subunit of the trimeric guanosine triphate-binding protein. There is no specific treatment for this syndrome. Treatment is generally symptomatic. This paper reported three cases of McCune-Albright syndrome and reviewed the relevant literatures regarding to the pathogenesis, pathological features, diagnosis and treatment. All three cases presented with a characteristic triad: polyostotic fibrous dysplasia, sexual precocity and hyperpigmented macules and were thus definitely diagnosed with McCune-Albright syndrome.
authors.affiliation: Department of Pediatrics, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. doctorlly@yahoo.com.cn
authors.forename: Li-Yang
authors.initials: LY
authors.lastname: Liang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Meng
authors.forename: Qiao-Hui
authors.initials: QH
authors.lastname: Zeng
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Li
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D011379:Prognosis