Regulation of cellular senescence by Rb2/p130.
Growth regulatory functions of Rb2/p130, which aim at a sustained arrest such as in quiescent or differentiated cells, qualify the protein also to act as a central regulator of growth arrest in cellular senescence. In this respect, Rb2/p130 functions are connected to signaling pathways induced by p53, which is a master regulator in cellular senescence. Here, we summarize the pathways, which specify pRb2/p130 to control this arrest program and distinguish its functions from those of pRb/p105.
Helmbold
H
H
Heinrich-Pette-Institute for Experimental Virology and Immunology at the University of Hamburg, Martinistr, Hamburg, Germany.
Deppert
W
W
Bohn
W
W
D000818:Animals; D002454:Cell Differentiation; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D011230:Precancerous Conditions / Q000473:pathology; D016160:Retinoblastoma Protein / Q000502:physiology*; D050717:Retinoblastoma-Like Protein p130 / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D016160:Retinoblastoma Protein; D050717:Retinoblastoma-Like Protein p130; D016159:Tumor Suppressor Protein p53