title: Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases.
abstract: The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand. niklas@tropmedres.ac
authors.forename: Niklas
authors.initials: N
authors.lastname: Lindegardh
authors.forename: Geraint R
authors.initials: GR
authors.lastname: Davies
authors.forename: Tinh Hien
authors.initials: TH
authors.lastname: Tran
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
authors.forename: Pratap
authors.initials: P
authors.lastname: Singhasivanon
authors.forename: Nicholas P J
authors.initials: NP
authors.lastname: Day
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000097:blood / Q000493:pharmacokinetics*; D004950:Esterases / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D010755:Organophosphates / Q000097:blood / Q000493:pharmacokinetics; D053139:Oseltamivir / Q000097:blood / Q000493:pharmacokinetics*; D011355:Prodrugs / Q000493:pharmacokinetics*
chemical_list: D000998:Antiviral Agents; D010755:Organophosphates; D011355:Prodrugs; D053139:Oseltamivir; D004950:Esterases