[Study on spray-drier preparation technology of weitai granules using orthogonal experiments].
OBJECTIVE
To screen preparation technique in order to raise the end-product and economical efficiency of spray-drier preparation technology of weitai granules.


METHODS
Newly Fluid-bed-spray-drier-granulation technique was adoped and taken extracting technique, temperature of exit and entry and the matching of accessories as inspecting factors, two levels of each factors, end-product and the water content of semi-finished weitai granules as inspecting marker, the best preparation technique of weitai granules was screened by orthogonal desing.


RESULTS
Among the 3 factors, the matching of accessories was most notalbe (P < 0.01), next was the temperature of exit and entry (P < 0.05). However, the extracting technique was of little importance (P > 0.05).


CONCLUSIONS
The optimum spray-drier granulation technique of weitai granules is A3B1C3.
Qu
Cai-Hong
CH
Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Yang
Li
L
Chen
Zhi-Liang
ZL
D000269:Adhesives; D003890:Desiccation / Q000379:methods; D004338:Drug Combinations; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification*; D007785:Lactose / Q000008:administration & dosage; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D011208:Powders; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D014867:Water / Q000008:administration & dosage
D000269:Adhesives; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011208:Powders; D014867:Water; D007785:Lactose