title: IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
abstract: The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.
authors.affiliation: Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Kenya
authors.initials: K
authors.lastname: Honda
authors.forename: Tadatsugu
authors.initials: T
authors.lastname: Taniguchi
mesh_terms: D000818:Animals; D003600:Cytosol / Q000276:immunology* / Q000378:metabolism; D004194:Disease; D006801:Humans; D050835:Interferon Regulatory Factors / Q000276:immunology* / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
chemical_list: D050835:Interferon Regulatory Factors; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors