Synthesis of 3-fluoroazetidines.
N-(Alkylidene or 1-arylmethylidene)-2-propenylamines were regiospecifically functionalized to novel N-(alkylidene or 1-arylmethylidene)-3-bromo-2-fluoropropylamines, which were proven to be excellent precursors for 3-fluoroazetidines.
Van Brabandt
Willem
W
Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium.
Verniest
Guido
G
De Smaele
Dirk
D
Duvey
Guillaume
G
De Kimpe
Norbert
N
D001384:Azetidines / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D017611:Fluorine Compounds / Q000737:chemistry; D013237:Stereoisomerism
D001384:Azetidines; D017611:Fluorine Compounds