title: Sleep patterns over 15-day period in rats with spinal cord injury.
abstract: METHODS
  Experimental, controlled trial.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate over a 15-day period alterations in sleep pattern of rats after spinal cord injury (SCI).
  
  
  METHODS
  Federal University of São Paulo, Department of Psychobiology.
  
  
  METHODS
  In total, 20 male Wistar rats were used. The rats were divided in two groups: SHAM and SCI. The rats were submitted to the following procedures: electrode insertion surgery, 24 h duration baseline sleep recording, SCI (level T9) and subsequent sleep recording for 15 consecutive days.
  
  
  RESULTS
  The results showed a reduction in sleep efficiency in the light period for Days 1-3, 5, 10 and 12 after SCI in relation to the SHAM group, with alterations in total waking time and sleep stages. Limb movements were observed 4 days after SCI.
  
  
  CONCLUSIONS
  The present findings suggest that SCI may be heavily involved in altering sleep pattern in SCI subjects and that the inactivity caused by SCI may be exacerbating this altered sleep pattern.
authors.affiliation: Department of Psychobiology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: A M
authors.initials: AM
authors.lastname: Esteves
authors.forename: M T
authors.initials: MT
authors.lastname: Mello
authors.forename: C F R
authors.initials: CF
authors.lastname: Squarcini
authors.forename: C L P
authors.initials: CL
authors.lastname: Lancellotti
authors.forename: A
authors.initials: A
authors.lastname: Comparoni
authors.forename: S
authors.initials: S
authors.lastname: Tufik
mesh_terms: D000758:Anesthesia; D000818:Animals; D001143:Arousal / Q000502:physiology; D004567:Electrodes, Implanted; D004569:Electroencephalography; D008297:Male; D009068:Movement / Q000502:physiology; D017286:Polysomnography; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology; D013119:Spinal Cord Injuries / Q000523:psychology*; D013238:Stereotaxic Techniques; D014851:Wakefulness / Q000502:physiology