[Effect of Pentavac and MMR vaccination on the intestine.].
OBJECTIVE
The safety of infant vaccination has been questioned in recent years. In particular it has been suggested that the measles, mumps and rubella (MMR) vaccination leads to brain damage manifesting as autism consequent to the development of an "enterocolitis" in the immediate post-vaccination period.


OBJECTIVE
To assess if MMR vaccination is associated with sub-clinical intestinal inflammation which is central to the autistic "enterocolitis" theory. The study was not designed to test directly the association of autism to MMR vaccination.


METHODS
We studied 109/20 infants, before and two and four weeks after immunization with Pentavac and MMR vaccines, for the presence of intestinal inflammation (faecal calprotectin).


RESULTS
Neither vaccination was associated with any significant increase in faecal calprotectin concentrations.


CONCLUSIONS
The failure of the MMR vaccination to cause an intestinal inflammatory response provides evidence against the proposed gut-brain interaction that is central to the autistic "enterocolitis" hypothesis.
Thornjóðleifsson
Bjarni
B
Landspitali University Hospital, Hringbraut, 101 Reykjavík, Iceland. bjarnit@landspitali.is.
Davíðsdóttir
Katrín
K
Agnarsson
Ulfur
U
Theodórs
Arndís
A
Gunnarsdóttir
Aðalbjœrg
A
Mœller
Elva
E
Jónsdóttir
Auður
A
Sigþórsson
Guðmundur
G
Kjeld
Matthías
M
Bjarnason
Ingvar
I