Common SNPs of APM1 gene are not associated with hypertension or obesity in Chinese population.
OBJECTIVE
To investigate whether the common variants 45T/G and 276G/T in APM1 gene were associated with hypertension combined with obesity (HO) and related clinical features in Chinese Han population.


METHODS
A case-control study design was applied. Common polymorphisms of 45T/G and 276G/T were genotyped by PCR product sequencing in 484 cases with HO and 502 controls with normal blood presure and BMI < 25.


RESULTS
The genotype and allele frequencies of 45T/G, 276G/T, and haplotype defined by the two variants in cases did not differ from those in controls. The means of blood pressure, BMI and waist-hip ratio did not differ among genotypes of the two polymorphisms and haplotypes. Among lipid profiles, only serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in T allele carriers than that in non-T carriers after adjusting possible confounding factors (1.21 vs 1.32 mmol/L, P=0.0001).


CONCLUSIONS
Polymorphisms of 45T/G and 276G/T in APM1 gene are not associated with hypertension or obesity, or their clinical features in Chinese Han population. Common polymorphism of 45T/G might be associated with serum HDL-C levels in Chinese.
Yan
Wei-Li
WL
Division of Population Genetics and Prevention, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen
Shu-Feng
SF
Huang
Jian-Feng
JF
Shen
Yan
Y
Qiang
Bo-Qin
BQ
Liu
Dong-Hai
DH
Gu
Dong-Feng
DF
D052242:Adiponectin / Q000235:genetics* / Q000502:physiology; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D009765:Obesity / Q000150:complications / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics* / Q000502:physiology; D044382:Population Groups; D049629:Waist-Hip Ratio
D052242:Adiponectin; D008055:Lipids; D008075:Lipoproteins, HDL