title: [Expression of E-cadherin and beta-catenin in Bowen's disease and squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the involvement of E-cadherin-catenin adhesion system in Bowen's disease (BD) and cutaneous squamous cell carcinoma (SCC).
  
  
  METHODS
  Fifteen normal skin, 28 BD and 18 SCC specimens were stained with monoclonal antibodies against E-cadherin and beta-catenin. Evaluation of the staining results was performed with semi-quantification of the pattern and intensity of staining, percentage of positive cells, and cytoplasmic staining.
  
  
  RESULTS
  Normal skins strongly expressed membranous E-cadherin and beta-catenin, but their expression was remarkably reduced in BD and SCC. Abnormal staining of beta-catenin was observed in the cytoplasm or cell nuclei of BD and SCC.
  
  
  CONCLUSIONS
  Abnormal expression of the E-cadherin/catenin complex is common in SCC and BD.
authors.affiliation: Department of Dermatology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Zheng-xiao
authors.initials: ZX
authors.lastname: Li
authors.forename: Zhen-hui
authors.initials: ZH
authors.lastname: Peng
authors.forename: Fan-pu
authors.initials: FP
authors.lastname: Ji
authors.forename: Jing-yi
authors.initials: JY
authors.lastname: Yuan
authors.forename: Min
authors.initials: M
authors.lastname: Pan
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001913:Bowen's Disease / Q000378:metabolism* / Q000473:pathology; D015820:Cadherins / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D051176:beta Catenin / Q000096:biosynthesis*
chemical_list: D015820:Cadherins; D051176:beta Catenin