Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus.
A library of hydroxycinnamic acid amides (HCAAs) and analogues were synthesized using solid-phase synthesis technique. These compounds were screened for antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Dihydrocaffeoyl analogues showed activity against VRSA which were better than the reference drugs, vancomycin and oxacillin. These compounds also exhibited antibacterial activity against MRSA, which were more potent than oxacillin.
Yingyongnarongkul
Boon-ek
BE
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok 10240, Thailand. boonek@raml.ru.ac.th
Apiratikul
Nuttapon
N
Aroonrerk
Nuntana
N
Suksamrarn
Apichart
A
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002110:Caffeine / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D003373:Coumaric Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D004338:Drug Combinations; D000431:Ethanol / Q000737:chemistry / Q000494:pharmacology; D016106:Methicillin Resistance / Q000187:drug effects* / Q000502:physiology; D010068:Oxacillin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D020713:Vancomycin Resistance / Q000187:drug effects* / Q000502:physiology
D000577:Amides; D000900:Anti-Bacterial Agents; D003373:Coumaric Acids; D004338:Drug Combinations; C503306:caffeinol; D002110:Caffeine; D000431:Ethanol; D010068:Oxacillin