title: Sulthiame therapy for continuous spike and wave in slow-wave sleep.
abstract: Corticosteroids are often considered as the first therapeutic choice in children with continuous spike and wave in slow-wave sleep on electroencephalogram; however, they are associated with significant adverse effects. "Idiopathic" forms of continuous spike and wave in slow-wave sleep may represent the severe end of the spectrum of benign rolandic epilepsy of childhood. This report describes a 5-year-old male with language delay who presented with a single focal-onset, nocturnal seizure and had continuous spike and wave in slow-wave sleep on electroencephalography. After 1 month of sulthiame therapy, his electroencephalographic abnormality had resolved, and his language development improved.
authors.affiliation: Department of Pediatrics, University of Calgary, Calgary, Canada. elaine.wirrell@calgaryhealthregion.ca
authors.forename: Elaine
authors.initials: E
authors.lastname: Wirrell
authors.forename: Alice Wen-Chi
authors.initials: AW
authors.lastname: Ho
authors.forename: Lorie
authors.initials: L
authors.lastname: Hamiwka
mesh_terms: D002675:Child, Preschool; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D012890:Sleep / Q000502:physiology; D013843:Thiazines / Q000627:therapeutic use*; D000096926:Benzenesulfonamides
chemical_list: D013843:Thiazines; C084593:sulthiame; D000096926:Benzenesulfonamides