Inferring the chemical mechanism from structures of enzymes.
Chemistry has once again embraced the study of enzyme mechanism as a core discipline. Chemists are uniquely able to contribute to the analysis of enzymes through their understanding of the reactivity of atoms. In this tutorial review for the Corday-Morgan medal, I will concentrate on the work from my lab over the past six years. I discuss enzymes which transform carbohydrates and incorporate halogens. The tutorial review will emphasise the strengths and limitations of structural biology as a means to deducing the chemical mechanism.
Naismith
James H
JH
Centre for Biomolecular Science, The University, St Andrews, UKKY16 9ST. Naismith@st-and.ac.uk
D000818:Animals; D050260:Carbohydrate Metabolism; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D006219:Halogens / Q000737:chemistry / Q000378:metabolism; D009711:Nucleotides / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D004798:Enzymes; D006219:Halogens; D009711:Nucleotides