title: [Two patients with mumps].
abstract: Two patients, men aged 17 and 19 years respectively, were admitted with parotitis epidemica and orchitis caused by mumps. The second patient also had meningitis. PCR analysis revealed that, in both cases, the causative agentwas a mumps virus that was genetically related to a wild-type virus responsible for an outbreak in Singapore. This viral strain was also responsible for a mumps outbreak at Hotel School The Hague in September 2004. Both patients were not fully vaccinated. Both patients were from regions in which clustering of patients with clinical signs of mumps has been seen. Interestingly, a number of patients with confirmed mumps had been fully vaccinated. Possible explanations for the increase in mumps cases include low vaccination and immunity levels, primary and secondary vaccine failure and the emergence of genetically disparate mumps viruses.
authors.affiliation: Jeroen Bosch Ziekenhuis, Postbus 90.153, 5200 ME's-Hertogenbosch.
authors.forename: S E
authors.initials: SE
authors.lastname: van Brummelen
authors.forename: E
authors.initials: E
authors.lastname: de Vries
authors.forename: P M
authors.initials: PM
authors.lastname: Schneeberger
authors.forename: R S
authors.initials: RS
authors.lastname: van Binnendijk
authors.forename: P
authors.initials: P
authors.lastname: Lestrade
authors.forename: P C
authors.initials: PC
authors.lastname: Wever
mesh_terms: D000293:Adolescent; D000328:Adult; D006801:Humans; D008297:Male; D009107:Mumps / Q000175:diagnosis* / Q000821:virology; D009108:Mumps Vaccine / Q000276:immunology*; D009109:Mumps virus / Q000235:genetics* / Q000276:immunology*; D014611:Vaccination / Q000592:standards
chemical_list: D009108:Mumps Vaccine