title: Impaired cerebral autoregulation and 6-month outcome in children with severe traumatic brain injury: preliminary findings.
abstract: The objective of this study was to describe the incidence of impaired cerebral autoregulation and to describe the relationship between impaired cerebral autoregulation and outcome after severe pediatric traumatic brain injury (TBI). We prospectively examined cerebral autoregulation in 28 children<or=17 (10+/-5) years with a Glasgow coma scale score<9 within the first 72 h of pediatric intensive care unit admission. Children with isolated focal TBI were excluded. Glasgow outcome scores (GOS) were collected at hospital discharge, as well as 3 and 6 months after severe TBI. GOS<4 reflected poor outcome. Cerebral autoregulation was impaired in 12/28 children. An autoregulatory index<0.4 was associated with GOS<4 at 6 months (p=0.005). Impaired cerebral autoregulation, early after severe pediatric TBI, was associated with a poor 6-month outcome.
authors.affiliation: Department of Anesthesiology, University of Washington, Seattle, WA 98104, USA. vavilala@u.washington.edu
authors.forename: M S
authors.initials: MS
authors.lastname: Vavilala
authors.forename: S
authors.initials: S
authors.lastname: Muangman
authors.forename: Nuj
authors.initials: N
authors.lastname: Tontisirin
authors.forename: D
authors.initials: D
authors.lastname: Fisk
authors.forename: C
authors.initials: C
authors.lastname: Roscigno
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
authors.forename: C
authors.initials: C
authors.lastname: Kirkness
authors.forename: J J
authors.initials: JJ
authors.lastname: Zimmerman
authors.forename: Randall
authors.initials: R
authors.lastname: Chesnut
authors.forename: A M
authors.initials: AM
authors.lastname: Lam
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000375:Aging / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D023261:Glasgow Outcome Scale / Q000706:statistics & numerical data / Q000639:trends; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D013223:Statistics as Topic