[Laboratory diagnosis of infection caused by Borrelia burgdorferi].
The laboratory diagnosis of Lyme disease in Denmark is reviewed with recommendations for serological testing. In Denmark the laboratory testing is performed with an ELISA technique. Most laboratories use an assay based on purified flagella antigen. The two-tier approach with Western Blot as confirmatory testing is not recommended since the contribution to the diagnostic specificity is only marginal. Predictive values of Lyme serology are presented, based on the estimated prevalence of the different stages of Lyme disease in Denmark.
Dessau
Ram B
RB
Dansk Selskab for Klinisk Mikrobiologi, Dansk Selskab for Infektionsmedicin. ram.dessau@dadlnet.dk
Bangsborg
Jette M
JM
Jensen
Tove P Ejlertsen
TP
Hansen
Klaus
K
Lebech
Anne-Mette K
AM
Andersen
Christian Østergaard
CØ
D000907:Antibodies, Bacterial / Q000096:biosynthesis; D015153:Blotting, Western; D025065:Borrelia burgdorferi / Q000235:genetics / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D020852:Lyme Neuroborreliosis / Q000175:diagnosis / Q000276:immunology; D012698:Serologic Tests
D000907:Antibodies, Bacterial