title: Radiological damage in patients with rheumatoid arthritis on sustained remission.
abstract: OBJECTIVE
  To assess the radiological damage progression in patients with recent rheumatoid arthritis in sustained remission.
  
  
  METHODS
  A cohort of 191 patients with active early (<1 year) rheumatoid arthritis was prospectively assessed at baseline, 3 and 5 years by the Disease Activity Score (DAS) and the Sharp-van der Heijde Score (SHS) for radiographic damage. Patients in remission (DAS<1.6) at the 3-year and 5-year time points were compared with patients with a persistently active rheumatoid arthritis by Wilcoxon's signed rank test.
  
  
  RESULTS
  57 patients died, were lost to follow-up or had incomplete data; 30 (15.7% of those who completed) patients were in remission at 3 and 5 years. The SHS in these two groups was not significantly different at baseline (p = 0.15), but was lower in the remission group at 5 years (p = 0.0047). The median (IQR) radiographic score increased from 0.5 (0-7) at baseline to 2.5 (0-14) after 5 years for the remission group (p = 0.18) and from 2 (0-7) to 13 (3-29) in the group with active rheumatoid arthritis (p<0.001). 5 (16.7%) patients in remission had relevant progression of radiographic damage (ie, progression >4.1 points) and 6 (20%) presented new erosions in a previously unaffected joint between the third and the fifth years.
  
  
  CONCLUSIONS
  Patients with early rheumatoid arthritis in sustained remission did not present statistically significant radiographic degradation at the group level; nevertheless, 16.7% of these patients did present degradation. Absence of progression should be part of the remission definition in rheumatoid arthritis.
authors.affiliation: Immuno-Rhumatologie, Montpellier I University, Centre Hospitalier Universitaire Lapeyronie, Montpellier, France.
authors.forename: G
authors.initials: G
authors.lastname: Cohen
authors.forename: L
authors.initials: L
authors.lastname: Gossec
authors.forename: M
authors.initials: M
authors.lastname: Dougados
authors.forename: A
authors.initials: A
authors.lastname: Cantagrel
authors.forename: P
authors.initials: P
authors.lastname: Goupille
authors.forename: J P
authors.initials: JP
authors.lastname: Daures
authors.forename: N
authors.initials: N
authors.lastname: Rincheval
authors.forename: B
authors.initials: B
authors.lastname: Combe
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011859:Radiography; D012074:Remission Induction; D012720:Severity of Illness Index