title: Use of freeze-dried bone allograft with platelet-derived growth factor for revision of a glenoid component.
abstract: Glenoid replacement is technically challenging. Removal of a cemented glenoid component often results in a large osseous defect which makes the immediate introduction of a revision prosthesis almost impossible. We describe a two-stage revision procedure using a reversed shoulder prosthesis. Freeze-dried allograft with platelet-derived growth factor was used to fill the glenoid defect. Radiological incorporation of the allograft was seen and its consistency allowed the placement of a screwed glenoid component. There were no signs of new mature bone formation on histological examination. The addition of platelet-derived growth factor to the allograft seems to contribute to an increase in incorporation and hardness, but does not promote the growth of new bone.
authors.affiliation: Department of Orthopaedic Surgery, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain. lpeidro@clinic.ub.es
authors.forename: L
authors.initials: L
authors.lastname: Peidro
authors.forename: J M
authors.initials: JM
authors.lastname: Segur
authors.forename: D
authors.initials: D
authors.lastname: Poggio
authors.forename: P Fernandez
authors.initials: PF
authors.lastname: de Retana
mesh_terms: D000368:Aged; D019643:Arthroplasty, Replacement / Q000379:methods*; D016025:Bone Transplantation / Q000379:methods*; D005612:Freeze Drying / Q000379:methods*; D006801:Humans; D007595:Joint Prosthesis; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D011859:Radiography; D012086:Reoperation; D012785:Shoulder Joint / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D010982:Platelet-Derived Growth Factor