title: 123I-Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism.
abstract: Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed (123)I-Ioflupane single-photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, (123)I-Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, (123)I-Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome.
authors.affiliation: Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Gaig
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Martí
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tolosa
authors.forename: Francesc
authors.initials: F
authors.lastname: Valldeoriola
authors.forename: Pilar
authors.initials: P
authors.lastname: Paredes
authors.forename: Francisco Juan
authors.initials: FJ
authors.lastname: Lomeña
authors.forename: Fernando
authors.initials: F
authors.lastname: Nakamae
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D011618:Psychotic Disorders / Q000150:complications; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes / Q000493:pharmacokinetics
chemical_list: D007457:Iodine Radioisotopes; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane