title: Incidence of and risk factors for dysplasia in mucosectomy area in ulcerative colitis patients undergoing restorative proctocolectomy.
abstract: OBJECTIVE
  We evaluated the incidence of dysplasia in the mucosectomy area using resected specimens to determine preoperative risk factors for the occurrence of dysplasia in this area.
  
  
  METHODS
  We prospectively studied a consecutive series of 137 patients, each of whom underwent a restorative proctocolectomy with a mucosectomy and hand-sewn ileal J-pouch anal anastomosis between January 2003 and December 2004. Sections from the anal transitional zone mucosa were taken from the dentate line to 2.5 cm above the resected line and stained with hematoxylin and eosin then characterized as indefinite for dysplasia, low-grade dysplasia, and high-grade dysplasia based on the criteria of an international working group for rectal mucosal atypia.
  
  
  RESULTS
  Dysplasia of the mucosectomy area was present in six (4.4%) of the patients, including one with low-grade and five with high-grade dysplasia. A multivariate analysis showed relations between age at time of surgery (>or=40 years) and duration of disease (>or=10 years) with a risk for development of mucosectomy area dysplasia.
  
  
  CONCLUSIONS
  The incidence of dysplasia of the mucosectomy area was 4.4%, and preoperative risk factors were shown to be duration of disease and age at time of surgery.
authors.affiliation: Second Department of Surgery, Hyogo College of Medicine, Hyogo, Japan. ikeuci2s@hyo-med.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Sagayama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishigami
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nakano
authors.forename: Motoi
authors.initials: M
authors.lastname: Uchino
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nakamura
authors.forename: Masafumi
authors.initials: M
authors.lastname: Noda
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yanagi
authors.forename: Takehira
authors.initials: T
authors.lastname: Yamamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003093:Colitis, Ulcerative / Q000150:complications* / Q000601:surgery; D006801:Humans; D015994:Incidence; D007413:Intestinal Mucosa / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D011230:Precancerous Conditions / Q000209:etiology* / Q000473:pathology; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D011446:Prospective Studies; D012307:Risk Factors