title: Is total colectomy the right choice in intractable slow-transit constipation?
abstract: BACKGROUND
  The aim of the study was to evaluate the functional results of surgical treatment for intractable slow-transit constipation and to establish that the importance of correct diagnosis and type of colon resection (total or segmental) is essential to achieve optimal outcome while minimizing side effects.
  
  
  METHODS
  Between 1995 and 2004, of the 450 patients presenting with chronic constipation, we further investigated 33 patients with a diagnosis of slow-transit constipation that had not improved with medical or rehabilitative treatment. Preoperative evaluation included a daily evacuation diary compiled using Wexner score, psychologic assessment, Medical Outcomes Study 36-item Short Form Health Survey (SF-36), radiologic investigation of colonic transit time, enema radiograph, colpo-cysto-defecography, anal manometry, and, in selected patients, colonoscopy and pudendal nerve terminal motor latency. In 15 cases, the cause of constipation was colonic slow-transit (with a mean Wexner score of 22), which was always associated with dolichocolon. The other 18 patients presented outlet obstruction, and, therefore, these results are not included in the present report. The 15 patients with slow-transit constipation were submitted to total laparoscopic colectomy (2), total open colectomy (6), and left laparoscopic hemicolectomy for left colonic slow-transit (7).
  
  
  RESULTS
  Mean follow-up was 38 months. All patients except 1 presented improvement in symptoms with daily evacuations (P < .01; mean Wexner score, 6). Furthermore, results of the SF-36 test showed an improvement in the perception of physical pain, and the emotional, psychologic, and general health spheres after surgical treatment.
  
  
  CONCLUSIONS
  Meticulous preoperative evaluation of intractable slow-transit constipation may discriminate between the different causes of chronic constipation and thus avoid the well-known "Iceberg syndrome," which is responsible for many treatment failures.
authors.affiliation: Department of Digestive Diseases, Campus Bio-Medico University of Rome, Italy. v.ripetti@unicampus.it
authors.forename: Valter
authors.initials: V
authors.lastname: Ripetti
authors.forename: Damiano
authors.initials: D
authors.lastname: Caputo
authors.forename: Santi
authors.initials: S
authors.lastname: Greco
authors.forename: Rossana
authors.initials: R
authors.lastname: Alloni
authors.forename: Roberto
authors.initials: R
authors.lastname: Coppola
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003082:Colectomy / Q000379:methods*; D003106:Colon / Q000503:physiopathology* / Q000601:surgery*; D003248:Constipation / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010528:Peristalsis / Q000502:physiology; D011379:Prognosis; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome