title: Retinoblastoma incidence and survival in European children (1978-1997). Report from the Automated Childhood Cancer Information System project.
abstract: Based on 2283 cases of retinoblastoma diagnosed in children aged 0-14 years, incidence and survival in Europe during the period 1978-1997 are described. Data were provided to the Automated Childhood Cancer Information System (ACCIS) from 60 paediatric and general cancer registries. During 1988-1997, the cumulative incidence of retinoblastoma in the ACCIS regions was found to be between 44.2 and 67.9 per million births. The highest incidence was seen in the first year of life. The age-standardised (World standard) incidence rate for the age-range 0-14 years was 4.1 per million. Approximately one-third of cases had bilateral tumours. Overall incidence increased over the period 1978-1997 by 1% per year, as derived from a model adjusted for sex, age group and type of registry (general or paediatric). The 5-year survival rate improved from 89% to 95% during the period covered by the study. This improvement was seen in both unilateral and bilateral cases but was significant only for the unilateral tumours. Survival was lower in the East region, although smaller differences were also observed between the other four regions (British Isles, North, South and West). Availability and quality of registration data on retinoblastoma need to be improved for effective evaluation of incidence and survival.
authors.affiliation: Childhood Cancer Research Group, University of Oxford, 57 Woodstock Road, Oxford, OX2 6HJ, UK. angela.maccarthy@ccrg.oxford.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: MacCarthy
authors.forename: G J
authors.initials: GJ
authors.lastname: Draper
authors.forename: Eva
authors.initials: E
authors.lastname: Steliarova-Foucher
authors.forename: J E
authors.initials: JE
authors.lastname: Kingston
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual / Q000706:statistics & numerical data*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012042:Registries / Q000706:statistics & numerical data; D019572:Retinal Neoplasms / Q000453:epidemiology* / Q000401:mortality; D012175:Retinoblastoma / Q000453:epidemiology* / Q000401:mortality; D016019:Survival Analysis