A new diphenyl ether from marine-derived fungus Aspergillus sp. B-F-2.
A new diphenyl ether dimethyl 2,3'-dimethylosoate (1) together with three known compounds monomethylsulochrin (2), emodin (3), and questin (4) were isolated through bioassay-guided fractionations from the culture of a marine-derived fungus Aspergillus sp. B-F-2. The structures of these compounds were determined by spectroscopic methods. Cytotoxicities of compounds 1 and 2 against K562 cell line were preliminarily evaluated by the MTT method and flow cytometry.
Liu
Rui
R
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Qingdao.
Zhu
Weiming
W
Zhang
Yapeng
Y
Zhu
Tianjiao
T
Liu
Hongbing
H
Fang
Yuchun
Y
Gu
Qianqun
Q
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001230:Aspergillus / Q000378:metabolism*; D006801:Humans; D020014:K562 Cells; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014871:Water Microbiology
D000903:Antibiotics, Antineoplastic; D010647:Phenyl Ethers; C031538:phenyl ether