Lanostane triterpenoids from the Sri Lankan basidiomycete Ganoderma applanatum.
Two new lanostane-type triterpenoids, 3alpha,16alpha-dihydroxylanosta-7,9(11),24-trien-21-oic acid (1) and 3alpha,16alpha,26-trihydroxylanosta-7,9(11),24-trien-21-oic acid (2), along with three known lanostanoids, 16alpha-hydroxy-3-oxolanosta-7,9(11),24-trien-21-oic acid (3), 3alpha-carboxyacetoxy-24-methylen-23-oxolanost-8-en-26-oic acid (4), and 3alpha-carboxyacetoxy-24-methyl-23-oxolanost-8-en-26-oic acid (5), have been isolated from the EtOAc extract of the fruiting body of Ganoderma applanatum. The structures of 1, 2, and 3 were determined directly by the interpretation of spectroscopic data, while the structures of 4 and 5 were assigned by comparison of spectroscopic data against literature values.
de Silva
E Dilip
ED
Department of Chemistry, University of Colombo, P.O. Box 1490, Colombo 3, Sri Lanka. dilip.desilva@canterbury.ac.nz
van der Sar
Sonia A
SA
Santha
R G Lalith
RG
Wijesundera
Ravi L C
RL
Cole
Anthony L J
AL
Blunt
John W
JW
Munro
Murray H G
MH
D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D032902:Ganoderma / Q000737:chemistry*; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D013188:Sri Lanka; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
D014315:Triterpenes; D007810:Lanosterol