Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility.
OBJECTIVE
Crystallization of drugs formulated in the amorphous form may lead to reduced apparent solubility, decreased rate of dissolution and bioavailability and compromise the physical integrity of the solid dosage form. The purpose of this work was to develop thermodynamic approaches, both practical and theoretical, that will yield a better understanding of which factors are most important for determining the ability of polymers to stabilize amorphous active pharmaceutical ingredients (API).


METHODS
Lattice based solution models were used to examine miscibility criteria in API-polymer blends. Different methods were used to estimate the Flory-Huggins interaction parameter for model API-polymer systems consisting of felodipine or nifedipine with poly(vinylpyrrolidone) (PVP). These were melting point depression and determination of solubility parameters using group contribution theory. The temperature and enthalpy of fusion of crystalline API alone and the fusion temperature of the API in the presence of the polymer were measured by differential scanning calorimetry. The resultant thermal data were used to estimate the reduced driving force for crystallization and the solubility of the API in the polymer.


RESULTS
Flory-Huggins theory predicts that, for typical API-polymer systems, the entropy of mixing is always favorable and should be relatively constant. Due to the favorable entropy of mixing, miscibility can still be achieved in systems with a certain extent of unfavorable enthalpic interactions. For the model systems, interaction parameters derived from melting point depression were negative indicating that mixing was exothermic. Using these interaction parameters and Flory-Huggins theory, miscibility was predicted for all compositions, in agreement with experimental data. A model was developed to estimate the solubility of the API in the polymer. The estimated solubility of the model APIs in PVP is low suggesting that kinetic rather than thermodynamic stabilization plays a significant role in inhibiting crystallization.


CONCLUSIONS
The thermodynamics of API-polymer systems can be modeled using solution based theories. Such models can contribute towards providing an understanding of the compatibility between API and polymer and the mechanisms of physical stabilization in such systems.
Marsac
Patrick J
PJ
Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA.
Shamblin
Sheri L
SL
Taylor
Lynne S
LS
D000465:Algorithms; D002121:Calcium Channel Blockers / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019277:Entropy; D015736:Felodipine / Q000737:chemistry; D005544:Forecasting; D008956:Models, Chemical; D009543:Nifedipine / Q000737:chemistry; D010592:Pharmaceutic Aids / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D013816:Thermodynamics
D002121:Calcium Channel Blockers; D010592:Pharmaceutic Aids; D004364:Pharmaceutical Preparations; D011108:Polymers; D011205:Povidone; D009543:Nifedipine; D015736:Felodipine