title: Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman.
abstract: BACKGROUND
  Cutaneous lymphomas co-expressing CD56 and CD30 are very rare. They share a clinicopathological overlap with natural killer- (NK)/T-cell lymphomas and anaplastic large-cell lymphomas (ALCLs), two entities with widely disparate clinical behavior.
  
  
  METHODS
  We present a case of an immunocompetent 57-year-old Caucasian woman with a rapidly growing, angiodestructive and neuroinvasive primary cutaneous ALCL (PCALCL). The neoplastic population of large anaplastic CD30+ and CD56+ T cells was masked by a massive admixture of histiocytes and neutrophils. The partially ulcerated and pus-secreting tumor involved the forehead and scalp and was assessed as clinical stage IAE.
  
  
  RESULTS
  After chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone), the patient achieved a complete remission. Additionally, high-dose chemotherapy with autologous peripheral blood stem-cell transplantation was administered as a consolidation of complete remission, in which she has remained for 6 years.
  
  
  CONCLUSIONS
  This is the first CD30+ and CD56+ primary skin lymphoma to be reported on the head. The presented case carries a remarkable combination of clinicopathological features of PCALCL and NK-/T-cell lymphoma.
authors.affiliation: Department of Pathology, Medical Faculty Hospital, Charles University, Pilsen, Czech Republic. boudova@medima.cz
authors.forename: Ludmila
authors.initials: L
authors.lastname: Boudova
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
authors.forename: Pavel
authors.initials: P
authors.lastname: Jindra
authors.forename: Radek
authors.initials: R
authors.lastname: Sima
authors.forename: Tomás
authors.initials: T
authors.lastname: Vanecek
authors.forename: Vilem
authors.initials: V
authors.lastname: Kuntscher
authors.forename: Vozobulova
authors.initials: V
authors.lastname: Vera
authors.forename: Jiri
authors.initials: J
authors.lastname: Bouda
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
mesh_terms: D019002:CD56 Antigen / Q000032:analysis*; D005260:Female; D005546:Forehead; D006258:Head and Neck Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006644:Histiocytes / Q000166:cytology; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D012535:Scalp / Q000098:blood supply / Q000187:drug effects / Q000294:innervation / Q000473:pathology; D012878:Skin Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D033581:Stem Cell Transplantation
chemical_list: D019002:CD56 Antigen; D017730:Ki-1 Antigen