title: Taraxasterane- and ursane-type triterpenes from Nerium oleander and their biological activities.
abstract: Two new taraxasterane-type triterpenes, 20beta,28-epoxy-28alpha-methoxytaraxasteran-3beta-ol (1) and 20beta,28-epoxytaraxaster-21-en-3beta-ol (2), were isolated from an ethyl acetate extract of the leaves of Nerium oleander, together with ursane-type triterpenes, 28-nor-urs-12-ene-3beta,17beta-diol (3) and 3beta-hydroxyurs-12-en-28-aldehyde (4). The structures of 1 and 2 were established on the basis of their spectroscopic data. Anti-inflammatory activity of 1-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1). Cytotoxic activity of 1-4 was evaluated against four human cell lines, A-549, WI-38, VA-13, and HepG2 cells.
authors.affiliation: Graduate School of Science and Technology, Niigata University, Ikarashi, 2-8050, Niigata 950-2181, Japan.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Shujun
authors.initials: S
authors.lastname: Zhang
authors.forename: Liwei
authors.initials: L
authors.lastname: Fu
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
authors.forename: Junichi
authors.initials: J
authors.lastname: Sakai
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.forename: Wanxia
authors.initials: W
authors.lastname: Tang
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ogura
authors.forename: Takao
authors.initials: T
authors.lastname: Kataoka
authors.forename: Seiko
authors.initials: S
authors.lastname: Oka
authors.forename: Miwa
authors.initials: M
authors.lastname: Kiuch
authors.forename: Katutoshi
authors.initials: K
authors.lastname: Hirose
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ando
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects; D007564:Japan; D015394:Molecular Structure; D030007:Nerium / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C513759:20beta,28-epoxy-28alpha-methoxytaraxasteran-3beta-ol; C513760:20beta,28-epoxytaraxaster-21-en-3beta-ol; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D018799:Intercellular Adhesion Molecule-1