title: Plasma adiponectin and insulin resistance in new onset hypertension.
abstract: OBJECTIVE
  The data related to association among hypertension, insulin resistance, and plasma adiponectin concentration is controversial. We aimed to evaluate the relationships among these factors in a young hypertensive group who had no confounding factors.
  
  
  METHODS
  Thirty newly diagnosed and formerly untreated hypertensive males (mean age 23.4 +/- 4.0 yr; body mass index: 24.9 +/- 2.2 kg/m2), and 60 healthy control subjects (mean age 22.5 +/- 3.2 yr; body mass index: 24.6 +/- 1.6 kg/m2) were enrolled. Insulin resistance was calculated by homeostasis model assessment (HOMA).
  
  
  RESULTS
  The two groups were similar in terms of age, body mass index, fasting glucose, total cholesterol, HDL and LDL cholesterol, adiponectin, insulin, HOMA, and hsCRP levels. Mean triglyceride levels in hypertensive patients were significantly higher than the controls (p = 0.02).
  
  
  CONCLUSIONS
  These results indicate that young, newly diagnosed, uncomplicated patients with hypertension have similar plasma adiponectin levels and insulin sensitivities when compared to healthy controls. We suggest that high blood pressure itself may not be associated with insulin resistance or low adiponectin levels in patients with new onset, uncomplicated hypertension.
authors.affiliation: Gulhane School of Medicine, Department of Internal Medicine, Etlik, Ankara, Turkey. teomandogru@yahoo.com
authors.forename: Teoman
authors.initials: T
authors.lastname: Dogru
authors.forename: Alper
authors.initials: A
authors.lastname: Sonmez
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: M Ilker
authors.initials: MI
authors.lastname: Yilmaz
authors.forename: Selim
authors.initials: S
authors.lastname: Kilic
authors.forename: Taner
authors.initials: T
authors.lastname: Ozgurtas
authors.forename: Tayfun
authors.initials: T
authors.lastname: Eyileten
authors.forename: M Kemal
authors.initials: MK
authors.lastname: Erbil
authors.forename: I Hakki
authors.initials: IH
authors.lastname: Kocar
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D017668:Age of Onset; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides; D002097:C-Reactive Protein