title: Reconstructing human origins in the genomic era.
abstract: Analyses of recently acquired genomic sequence data are leading to important insights into the early evolution of anatomically modern humans, as well as into the more recent demographic processes that accompanied the global radiation of Homo sapiens. Some of the new results contradict early, but still influential, conclusions that were based on analyses of gene trees from mitochondrial DNA and Y-chromosome sequences. In this review, we discuss the different genetic and statistical methods that are available for studying human population history, and identify the most plausible models of human evolution that can accommodate the contrasting patterns observed at different loci throughout the genome.
authors.affiliation: Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Garrigan
authors.forename: Michael F
authors.initials: MF
authors.lastname: Hammer
mesh_terms: D000349:Africa; D005075:Biological Evolution; D041322:Chromosomes, Human, Y / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D003627:Data Interpretation, Statistical; D004641:Emigration and Immigration; D019143:Evolution, Molecular; D005260:Female; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic
chemical_list: D004272:DNA, Mitochondrial