A long-term study of dyslipidemia and dyslipoproteinemia in stable post-renal transplant patients.
BACKGROUND
Dyslipidemia is a major risk factor for atherosclerotic disease in renal transplant patients.


METHODS
The serum levels of lipids and lipoproteins were determined in the same 12 post-renal transplant patients (TX) 10-29 and 73-122 months after transplantation. Thirteen healthy subjects--i.e., without diabetes, endocrine disease, liver disease, active inflammatory disease, glucose intolerance, malignancy, obesity, and urinary protein--were used as a reference group. TX patients had stable renal function. Twelve patients received cyclosporine A and prednisone, six received lovastatin, and one received rapa and prednisone. Lipids and lipoprotein (apo)AI and B were determined using Roche kits. An anti-apoB antibody was used to separate apoB-containing apoCIII and apoE lipoproteins as triglyceride-rich lipoproteins (TRLs) in the non-HDL fraction from apoCIIInonB and apoEnonB in the HDL fraction.


RESULTS
In both groups of post-renal transplant patients, a statistically significant increase of TG, TC, and non-HDL-C levels was observed. Moreover, statistically significant changes were shown in total apoCIII and apoCIIInonB, as well as in TG/HDL-C and apoAI/apoCIII ratios, as compared to the reference group. On the other hand, in TX patients 73-122 months after transplantation, significantly higher concentrations of TC, LDL-C, and especially non-HDL-C were observed. It was shown that apoCIII, apoCIIInonB, apoB:CIII, and lipid and lipoprotein ratios as risk factors of atherosclerosis and renal risk factors were higher in these patients 73-122 months after transplantation.


CONCLUSIONS
TX patients in a long-term study showed that they had disturbed lipoprotein composition, and its consequence was hyperlipidemia, perhaps partly due to the increased use of immunosuppressants and steroids.
Kimak
Elzbieta
E
Interfaculty Department of Laboratory Diagnostics, Medical University, Lublin, Poland. elzbieta.kimak@wp.pl
Solski
Janusz
J
Baranowicz-Gaszczyk
Iwona
I
Ksiazek
Andrzej
A
D000328:Adult; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D011183:Postoperative Complications; D013997:Time Factors
D008055:Lipids