title: [Effects of green tea polyphenol on the behaviour of Alzheimer' s disease like mice induced by D-galactose and Abeta25-35].
abstract: OBJECTIVE
  To study the effects of green tea polyphenol (GTP) on the behaviour of Alzheimer' s Disease like mice induced by D-galactose and Abeta25-35.
  
  
  METHODS
  D-galactose (120 mg/kg) was intraperitoneally injected into mice for 12 weeks and Abeta25-35 (4nmol) was injected by icv to establish Alzheimer' s Disease like mice. The protective and therapeutic effects of GTP were determined by using water maze test, step down test, step through test and open field test.
  
  
  RESULTS
  GTP ameliorated the deleterious effects of D-galactose and Abeta25-35, and thereby improved the animal' s learning and memory, prolonged latency time, and the error numbers were significantly reduced. At the same time the autonomic activities were significantly increased.
  
  
  CONCLUSIONS
  GTP can improve the behaviour of Alzheimer' s Disease like mice induced by D-galactose and Abeta25-35.
authors.affiliation: Department of Pharmacology, Jinan University Pharmacy College, Guangzhou 510632, China.
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Lü
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Yang
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D016229:Amyloid beta-Peptides; D000818:Animals; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005690:Galactose; D006624:Hippocampus / Q000187:drug effects; D007859:Learning Disabilities / Q000188:drug therapy; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D059808:Polyphenols; D013662:Tea / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D005419:Flavonoids; D018696:Neuroprotective Agents; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013662:Tea; D005690:Galactose