Focus on triamcinolone acetonide as an adjunct to glaucoma filtration surgery.
Glaucoma is one of the most common causes of irreversible blindness worldwide. Despite continued advances in medical and laser therapy, incisional surgery still appears to be an important and for many cases the only option by which intraocular pressure is controlled. Unlike many other types of surgery in which complete healing of tissue would be a desirable outcome, glaucoma surgery seeks to achieve incomplete healing to allow aqueous humor to escape the eye. Pharmacologic modulation of wound healing is a hot topic in glaucoma filtration surgery. Although routine antifibrotic medications are associated with good results in modulating wound healing in glaucoma surgery, they carry with them the possibility for significant morbidity due to the adverse effects of treatment. Challenge continues to be to find a safe and effective agent for this purpose. Because of beneficial effects of triamcinolone acetonide in some conditions which are associated with secondary glaucoma and also potential effects of this agent in modulating wound healing process, we propose it as a useful adjunct to glaucoma filtration surgery. This approach may allow modulation of wound healing with less of the toxicity associated with commonly used antifibrotics (5-FU and mitomycin C).
Hosseini
Hamid
H
Shiraz University of Medical Sciences, Ophthalmology Department, Khalili Hospital, Shiraz, Iran. hosseini.hamid@gmail.com
Mehryar
Morsal
M
Farvardin
Mohsen
M
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018463:Filtering Surgery; D005901:Glaucoma / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide