title: Sequence analysis of a canine parvovirus isolated from a red panda (Ailurus fulgens) in China.
abstract: Canine parvovirus (CPV) was first recognized in the late 1970 s in dogs and has mutated and spread throughout the world in canid and felid species since then. In this study, a novel CPV was isolated from the endangered red panda (Ailurus fulgens) in China. Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the red panda parvovirus (RPPV) as a CPV-2a type. Substitution of Val for Gly at the conserved 300 residue in RPPV presents an unusual variation in the CPV-2a amino acid sequence and is further evidence for the continuing evolution of the virus. The 300 residue is important in distinguishing the antigenicity and host range of CPVs. The clinical significance and population impact of RPPV infection in captive red pandas in China is unknown and is an important topic for future research.
authors.affiliation: Institute of Zoology, Chinese Academy of Sciences, 25 Beisihuan Xilu, Haidian District, Beijing 100080, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: I Kati
authors.initials: IK
authors.lastname: Loeffler
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Kegong
authors.initials: K
authors.lastname: Tian
authors.forename: Fuwen
authors.initials: F
authors.lastname: Wei
mesh_terms: D053822:Ailuridae / Q000821:virology*; D000818:Animals; D036022:Capsid Proteins / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis* / Q000302:isolation & purification; D017993:Parvovirus, Canine / Q000235:genetics* / Q000302:isolation & purification*; D010802:Phylogeny; D020539:Sequence Analysis, Protein
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; C095548:capsid protein VP2, parvovirus B19