The number of genes changing expression after chronic exposure to code division multiple access or frequency DMA radiofrequency radiation does not exceed the false-positive rate.
Experiments with cultured C3H 10T 1/2 cells were performed to determine if exposure to cell phone radiofrequency (RF) radiations induce changes in gene expression. Following a 24 h exposure of 5 W/kg specific adsorption rate, RNA was extracted from the exposed and sham control cells for microarray analysis on Affymetrix U74Av2 Genechips. Cells exposed to 0.68 Gy of X-rays with a 4-h recovery were used as positive controls. The number of gene expression changes induced by RF radiation was not greater than the number of false positives expected based on a sham versus sham comparison. In contrast, the X-irradiated samples showed higher numbers of probe sets changing expression level than in the sham versus sham comparison.
Whitehead
Timothy D
TD
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Moros
Eduardo G
EG
Brownstein
Bernard H
BH
Roti Roti
Joseph L
JL
D000818:Animals; D002460:Cell Line; D005189:False Positive Reactions; D005786:Gene Expression Regulation / Q000528:radiation effects*; D051379:Mice; D011519:Proto-Oncogenes / Q000235:genetics; D011846:Radio Waves; D013997:Time Factors