Epibatidine isomers and analogues: structure-activity relationships.
Binding affinities for a range of epibatidine isomers and analogues at the alpha4beta2 and alpha3beta4 nAChR subtypes are reported; compounds having similar N-N distances to epibatidine show similar, high potencies.
White
Richard
R
Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK.
Malpass
John R
JR
Handa
Sandeep
S
Richard Baker
S
S
Broad
Lisa M
LM
Folly
Liz
L
Mogg
Adrian
A
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D007536:Isomerism; D018722:Nicotinic Agonists / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D019086:Bridged Bicyclo Compounds, Heterocyclic; D018722:Nicotinic Agonists; D011725:Pyridines; C082748:epibatidine