S-layer proteins as key components of a versatile molecular construction kit for biomedical nanotechnology.
Surface (S)-layer proteins and S-layer fusion proteins incorporating functional sequences, self-assemble into monomolecular lattices on solid supports and on various lipid structures. Based on these S-layer proteins, supramolecular assemblies can be constructed which are envisaged for label-free detection systems, as affinity matrix, as anti-allergic immuno-therapeutics, as membrane protein-based screening devices, and as drug targeting and delivery systems.
Schuster
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Center for NanoBiotechnology, University of Natural Resources and Applied Life Sciences Vienna, Gregor-Mendel-Strasse 33, 1180 Vienna, Austria. bernhard.schuster@boku.ac.at
Pum
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D
Sára
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Sleytr
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UB
D018926:Anti-Allergic Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000737:chemistry*; D032701:Biomimetics; D015374:Biosensing Techniques / Q000379:methods*; D016503:Drug Delivery Systems; D015195:Drug Design; D008562:Membrane Glycoproteins / Q000737:chemistry*; D015394:Molecular Structure; D036103:Nanotechnology / Q000379:methods*
D018926:Anti-Allergic Agents; D001426:Bacterial Proteins; D008562:Membrane Glycoproteins; C055764:S-layer proteins