Phosphine-free palladium catalyzed Mizoroki-Heck reaction using hydrazone as a ligand.
Glyoxal bishydrazones 1 and pyridyl-hydrazone 2b were prepared and examined as a ligand for the Mizoroki-Heck cross-coupling reaction of aryl halides and olefin. We found that PdCl2(MeCN)2/hydrazone ligand 1e was a phosphine-free efficient catalyst system for a variety of substrates to produce the Mizoroki-Heck coupling products in good yields.
Mino
Takashi
T
Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. tmino@faculty.chiba-u.jp
Shirae
Yoshiaki
Y
Sasai
Yousuke
Y
Sakamoto
Masami
M
Fujita
Tsutomu
T