title: Synthesis, characterization, and biological evaluation of M(I)(CO)3(NNO) complexes (M = Re, 99mTc) conjugated to 2-(4-aminophenyl)benzothiazole as potential breast cancer radiopharmaceuticals.
abstract: The synthesis and biological evaluation of new M(I)(CO)3(NNO) (M = Re, 99mTc) complexes attached to the antitumor agent 2-(4-aminophenyl)benzothiazole are reported. The fluorescent rhenium complex enters MCF-7 breast cancer cells but does not enter normal HFFF-2 and MRC-5 cells. The analogous radioactive 99mTc complex produces fast blood and soft tissue clearance when administered to healthy mice. These complexes are promising candidates for developing radiopharmaceuticals for imaging (99mTc) and targeted radiotherapy (186Re, 188Re) of breast cancer.
authors.affiliation: Institute of Biology, National Centre for Scientific Research Demokritos, 15310 Athens, Greece.
authors.forename: Stamatia
authors.initials: S
authors.lastname: Tzanopoulou
authors.forename: Ioannis C
authors.initials: IC
authors.lastname: Pirmettis
authors.forename: George
authors.initials: G
authors.lastname: Patsis
authors.forename: Maria
authors.initials: M
authors.lastname: Paravatou-Petsotas
authors.forename: Evangelia
authors.initials: E
authors.lastname: Livaniou
authors.forename: Minas
authors.initials: M
authors.lastname: Papadopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Pelecanou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D052160:Benzothiazoles; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D002460:Cell Line; D045744:Cell Line, Tumor; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012211:Rhenium; D013329:Structure-Activity Relationship; D013667:Technetium; D013844:Thiazoles / Q000737:chemistry*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: C111133:2-(4-aminophenyl)benzothiazole; D000970:Antineoplastic Agents; D052160:Benzothiazoles; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013844:Thiazoles; D012211:Rhenium; D013667:Technetium