title: An overview of permanent and semipermanent fillers.
abstract: The demand for safe, effective, long-lasting, biocompatible dermal filler materials is increasing. Many products that include synthetic polymers and autologous tissue have emerged that attempt to meet these criteria. An overview of injectable permanent fillers, including ArteFill, Aquamid, and silicone, and semipermanent fillers, including Radiesse, Sculptra, and autologous fat, is presented. A discussion of their composition, histologic characteristics, antigenicity, U.S. Food and Drug Administration approval status, indications for use, efficacy, injection technique, and adverse effects is provided.
authors.affiliation: Division of Plastic and Reconstructive Surgery, University of California, USA.
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Broder
authors.forename: Steven R
authors.initials: SR
authors.lastname: Cohen
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000273:Adipose Tissue / Q000637:transplantation; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002417:Cattle; D002482:Cellulose / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D017886:Durapatite / Q000009:adverse effects / Q000627:therapeutic use; D005549:Foreign-Body Reaction / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007279:Injections, Subcutaneous; D019344:Lactic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008353:Mannitol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008863:Microspheres; D011108:Polymers / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D019904:Polymethyl Methacrylate / Q000009:adverse effects / Q000627:therapeutic use; D019651:Plastic Surgery Procedures; D012060:Rejuvenation; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D015595:Skin Aging; D040521:Subcutaneous Tissue / Q000473:pathology; D014182:Transplantation, Autologous
chemical_list: D000180:Acrylic Resins; C486838:Aquamid; D001672:Biocompatible Materials; D020100:Hydrogels; C482305:New-Fill; D011108:Polymers; D012828:Silicones; D019344:Lactic Acid; D008353:Mannitol; D002482:Cellulose; D019904:Polymethyl Methacrylate; D017886:Durapatite