title: Piezoelectric ink jet processing of materials for medical and biological applications.
abstract: Many advanced medical and biological devices require microscale patterning of cells, proteins, and other biological materials. This article describes the use of piezoelectric ink jet processing in the fabrication of biosensors, cell-based assays, and other microscale medical devices. A microelectromechanical system-based piezoelectric transducer was used to develop uniform fluid flow through nozzles and to prepare well-defined microscale patterns of proteins, monofunctional acrylate ester, sinapinic acid, deoxyribonucleic acid (DNA), and DNA scaffolds on relevant substrates. Our results demonstrate that piezoelectric ink jet deposition is a powerful non-contact, non-destructive additive process for developing biosensors, cell culture systems, and other devices for medical and biological applications.
authors.affiliation: Dimatix Inc., Santa Clara, CA, USA.
authors.forename: Jan
authors.initials: J
authors.lastname: Sumerel
authors.forename: John
authors.initials: J
authors.lastname: Lewis
authors.forename: Andy
authors.initials: A
authors.lastname: Doraiswamy
authors.forename: Leila F
authors.initials: LF
authors.lastname: Deravi
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Sewell
authors.forename: Aren E
authors.initials: AE
authors.lastname: Gerdon
authors.forename: David W
authors.initials: DW
authors.lastname: Wright
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Narayan
mesh_terms: D000818:Animals; D001698:Biomedical Engineering; D015374:Biosensing Techniques; D001709:Biotechnology / Q000295:instrumentation / Q000379:methods*; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D003373:Coumaric Acids / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D004867:Equipment Design; D006801:Humans; D007281:Ink; D037742:Nanotubes, Carbon / Q000737:chemistry; D011327:Printing; D019809:Streptavidin / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D003373:Coumaric Acids; D037742:Nanotubes, Carbon; C073734:sinapinic acid; D004247:DNA; D019809:Streptavidin