A transcriptional logic for nuclear reprogramming.
Limitations on a differentiated cell's pluripotency can be erased by nuclear transfer or by fusion with embryonic stem cells, but attempts to recapitulate this process of nuclear reprogramming by molecular means have failed. In this issue of Cell, Takahashi and Yamanaka (2006) take a rational approach to identifying a suite of embryonic transcription factors whose overexpression restores pluripotency to adult somatic cells.
Rodolfa
Kit T
KT
The Stowers Medical Institute, Harvard Stem Cell Institute, Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Eggan
Kevin
K
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000166:cytology; D006822:Hybrid Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D019076:Transgenes
D014157:Transcription Factors