title: Localized purpura associated with lamotrigine.
abstract: Antiepileptic drug hypersensitivity syndrome consists of fever, rash, and internal organ involvement and usually occurs within the first 2 months of initiation of therapy. This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy. This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.
authors.affiliation: Department of Neurology, Division of Pediatric Neurology, Medical College of Wisconsin, Milwaukee, 53226, USA. KLefond@mcw.edu
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Amlie-Lefond
authors.forename: Judy L
authors.initials: JL
authors.lastname: Felgenhauer
authors.forename: Alan D
authors.initials: AD
authors.lastname: Leong
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004334:Drug Administration Schedule; D004828:Epilepsies, Partial / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D011693:Purpura / Q000139:chemically induced*; D014227:Triazines / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine