CSF BACE1 activity is increased in CJD and Alzheimer disease versus [corrected] other dementias.
To assess the diagnostic utility of CSF BACE1 activity for discriminating Alzheimer disease (AD) from other dementias, particularly Creutzfeldt-Jakob disease (CJD), the authors studied 26 patients with sporadic CJD, 21 patients with AD, and 21 patients with various non-AD, non-CJD dementias (DCs). CSF BACE1 activity was elevated in AD in comparison with DC (p = 0.01). Unexpectedly, CSF BACE1 activity was also increased in sporadic CJD (p = 0.02).
Holsinger
R M D
RM
University of Melbourne, Parkville, Victoria, 3010, Australia. d.holsinger@fhs.usyd.edu.au
Lee
J S
JS
Boyd
A
A
Masters
C L
CL
Collins
S J
SJ
D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid*; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000453:epidemiology; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; D001315:Australia / Q000453:epidemiology; D015415:Biomarkers / Q000134:cerebrospinal fluid; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000453:epidemiology; D003704:Dementia / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000453:epidemiology; D003937:Diagnosis, Differential; D010450:Endopeptidases / Q000134:cerebrospinal fluid*; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016875:tau Proteins
D048948:14-3-3 Proteins; D015415:Biomarkers; C054369:MAPT protein, human; D009419:Nerve Tissue Proteins; D016875:tau Proteins; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human