Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance.
Ghosh
Arun K
AK
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. akghosh@purdue.edu
Ramu Sridhar
Perali
P
Kumaragurubaran
Nagaswamy
N
Koh
Yasuhiro
Y
Weber
Irene T
IT
Mitsuya
Hiroaki
H
D000818:Animals; D000069454:Darunavir; D024882:Drug Resistance, Viral; D005663:Furans / Q000737:chemistry*; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*
D005663:Furans; D017320:HIV Protease Inhibitors; D008024:Ligands; D013449:Sulfonamides; C018674:tetrahydrofuran; D000069454:Darunavir