SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton.
The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.
Tzur
Yonatan B
YB
Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.
Wilson
Katherine L
KL
Gruenbaum
Yosef
Y
D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism / Q000502:physiology*; D005544:Forecasting; D008954:Models, Biological; D009685:Nuclear Envelope / Q000737:chemistry / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D010802:Phylogeny; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology
D009687:Nuclear Proteins