title: Clinical features and epileptogenesis of dysembryoplastic neuroepithelial tumor.
abstract: BACKGROUND
  Dysembryoplastic neuroepithelial tumor (DNT) frequently causes medically intractable epilepsy.
  
  
  OBJECTIVE
  The aim of this study was to investigate the basic mechanism of epileptogenecity of the tumor.
  
  
  METHODS
  Clinicopathological data in 13 cases of DNT and immunohistochemical changes of ionotropic glutamate receptor subunits in the tumor and peritumoral epileptogenic cortex were studied.
  
  
  CONCLUSIONS
  Magnetic resonance imaging combined with electroencephalography (EEG), electrocorticography, and depth-electrode EEG was valuable to localize complicated epileptogenic zones of the patients with DNT. Neuropathological examinations of the peritumoral cerebral cortex presenting abnormal spikes showed different histopathological grades of neuronal migration disorder (NMD). The tumor cells in DNT disclosed increased immunopositivities of N-methyl-D: -aspartate receptor 1 (NR1) and NR2A/B, and peritumoral epileptogenic NMD revealed increased immunopositivities of GluR2 and GluR3. The amplification of ionotropic glutamate receptor subunits in the tumor and peritumoral NMD may be the underlying cause of epileptic seizures in DNT patients.
authors.affiliation: Department of Pathology, Chonnam National University Medical School and Hospital, 5 Hakdong, Dongku, Gwangju, 501-746, South Korea. mclee@jnu.ac.kr
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Lee
authors.forename: Jang-Young
authors.initials: JY
authors.lastname: Kang
authors.forename: Myung-Bok
authors.initials: MB
authors.lastname: Seol
authors.forename: Hyung-Seok
authors.initials: HS
authors.lastname: Kim
authors.forename: Jae-Yeon
authors.initials: JY
authors.lastname: Woo
authors.forename: Ji-Shin
authors.initials: JS
authors.lastname: Lee
authors.forename: Shin
authors.initials: S
authors.lastname: Jung
authors.forename: Jae-Hyoo
authors.initials: JH
authors.lastname: Kim
authors.forename: Young-Jong
authors.initials: YJ
authors.lastname: Woo
authors.forename: Myung-Kyu
authors.initials: MK
authors.lastname: Kim
authors.forename: Hyung-Ihl
authors.initials: HI
authors.lastname: Kim
authors.forename: Seung-Up
authors.initials: SU
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018302:Neoplasms, Neuroepithelial / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D018091:Receptors, AMPA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
chemical_list: C409466:NR1 NMDA receptor; C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; C104723:glutamate receptor ionotropic, AMPA 3; C104722:glutamate receptor ionotropic, AMPA 2