A new role for CCR5 in innate immunity--binding to bacterial heat shock protein 70.
CCR5 has been associated with adaptive immune responses, because of its expression on effector and memory T cells, and dentric cells. In this issue of the European Journal of Immunology, Whittall et al. identify CCR5 as a receptor that binds bacterial heat shock protein 70 (HSP70). Thus HSP70 may stimulate responses by CCR5+ T cells or dendritic cells, particularly at epithelial surfaces. These findings imply a role for CCR5 in innate immunity, in addition to its more established role as a chemoattractant receptor for adaptive immune responses.
Mackay
Charles R
CR
Immunology and Inflammation Department, Garvan Institute of Medical Research, Darlinghurst, Australia. c.mackay@garvan.org.au
Sallusto
Federica
F
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001419:Bacteria / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation / Q000276:immunology; D019713:Receptors, CCR5 / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D018840:HSP70 Heat-Shock Proteins; D019713:Receptors, CCR5