Neutralization of macrophage migration inhibitory factor-novel approach for the treatment of immunoinflammatory disorders.
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays an important role in the pathogenesis of numerous inflammatory and autoimmune disorders. As such, it is an attractive therapeutic target for the treatment of these disorders. Several groups of possible MIF inhibitors have so far been identified, including anti-MIF antibodies, small chemical compounds and plant-derived inhibitors. This review presents current understanding of the effects of MIF neutralization in a number of experimental animal models of inflammatory and autoimmune diseases and discusses the potential problems in translating this kind of therapy into human subjects.
Cvetkovic
Ivana
I
Institute for Biological Research "Sinisa Stankovic", Despota Stefana 142, 11000 Belgrade, Serbia. branicevo@yahoo.com
Stosic-Grujicic
Stanislava
S
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000037:antagonists & inhibitors* / Q000276:immunology; D028321:Plant Preparations / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D007155:Immunologic Factors; D008263:Macrophage Migration-Inhibitory Factors; D028321:Plant Preparations