[Plasma orexin-A level in patients with obstructive apnea-hypopnea syndrome].
OBJECTIVE
To investigate the effect of uvulopalatopharyngoplasty (UPPP) on changes of plasma orexin-A levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).


METHODS
Fifty-four cases with OSAHS diagnosed by polysomnography were treated with uvulopalatopharyngoplasty and hyoid suspension. Plasma orexin-A levels in patients with OSAHS before and after surgical procedure 6 months, and in 20 healthy people with age,sex and BMI matched controls were measured by radioimmunoassay. The plasma was deproteinized by chromatography. Correlations between orexin-A levels and AHI, MAI and SaO2 min were analyzed.


RESULTS
The plasma orexin-A levels in the OSAHS group was significantly higher than those in the control group (P < 0.01). Plasma orexin A levels in the patients with OSAHS correlated positively with the AHI (r < 0.658, P < 0.05) and MAI. (r = 0.464, P < 0.05) but correlated negatively with the SaO2 min. The plasma orexin-A levels of 54 responders after 6 months were significantly decreased (P < 0.01) than that of pre-operation, and there is no correlation between plasma orexin-A levels and BMI.


CONCLUSIONS
The plasma orexin-A levels in the OSAHS patients are increased which may be caused by repeated nocturnal apnoea and hypoxia due to OSAHS. Surgical procedures may decreased the plasma orexin-A levels.
Yao
Xingqi
X
Department of Otolaryngology, Wuhan General Hospital of PLA, Wuhan 430070, China. yaohq64@sina.com
Yang
Hui
H
Zhang
Guifeng
G
Tang
Ying
Y
D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D008875:Middle Aged; D009479:Neuropeptides / Q000097:blood*; D000068797:Orexins; D010949:Plasma / Q000737:chemistry*; D020181:Sleep Apnea, Obstructive / Q000097:blood*
C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins