title: Rotavirus disease in Uzbekistan: cost-effectiveness of a new vaccine.
abstract: We evaluated the cost-effectiveness of rotavirus vaccination in Uzbekistan from the healthcare system and societal perspectives. Disease burden was estimated using national statistics on hospitalizations and deaths, and international estimates of under-five mortality. Without vaccination, the risk for rotavirus hospitalization by age 5 is 10 per 1000 children. Rotavirus hospitalizations cost US$ 406,000 annually, of which US$ 360,000 (89%) is for medical expenses and US$ 46,000 (11%) is for non-medical and indirect costs. Rotavirus mortality rate at 0.7 per 1000 derived from national data was three-fold lower than the same rate calculated from international estimates of under-five mortality. Rotavirus vaccination could reduce hospitalizations and deaths by 91% and avert US$ 370,000 in hospitalization costs alone. Vaccination would be cost-effective with vaccine prices in a range of US$ 2-25 per child. However, the cost-effectiveness is greatly influenced by mortality, vaccine price and vaccine efficacy.
authors.affiliation: Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, GA, USA. elmira.isakbaeva@fhi.no
authors.forename: E T
authors.initials: ET
authors.lastname: Isakbaeva
authors.forename: E
authors.initials: E
authors.lastname: Musabaev
authors.forename: L
authors.initials: L
authors.lastname: Antil
authors.forename: R
authors.initials: R
authors.lastname: Rheingans
authors.forename: R
authors.initials: R
authors.lastname: Juraev
authors.forename: R I
authors.initials: RI
authors.lastname: Glass
authors.forename: J S
authors.initials: JS
authors.lastname: Bresee
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D005260:Female; D017048:Health Care Costs; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D022243:Rotavirus Vaccines / Q000191:economics / Q000276:immunology*; D014611:Vaccination / Q000191:economics*
chemical_list: D022243:Rotavirus Vaccines