title: Management of an acute thermal injury with subatmospheric pressure.
abstract: OBJECTIVE
  This article reports the first application of subatmospheric pressure management to a deep, partial-thickness human thermal burn.
  
  
  METHODS
  After cleaning the wound, the decision was made to treat the hand and distal forearm with subatmospheric pressure (V.A.C., KCI, Inc, San Antonio, Tex). The sponge was applied directly to the burned skin without additional interface at approximately 6 hours after injury. The dressing was maintained at a continuous negative pressure of 125 mm Hg over the next 40 hours, with interruption only for routine clinical evaluation at 5, 16, and 24 hours after initiation of treatment. This was accomplished by opening the dressing without completely changing it. The treatment was tolerated well by the patient, requiring no excessive pain medication. After the subatmospheric pressure treatment was stopped, the wound appeared to be of indeterminate depth and the patient was started on twice daily applications of silver sulfadiazine.
  
  
  RESULTS
  The clinical impression at this time was that the hand burn had not progressed but had stabilized and had minimal edema. He was followed as an outpatient and returned to work by 8 weeks. At approximately 4 weeks postinjury, his skin not only was functional but also appeared more normal, with less hyperemia than adjacent areas treated with topical antibacterials.
  
  
  CONCLUSIONS
  The present case does not prove that subatmospheric pressure treatment prevents burn wound progression. However, when combined with the previously reported laboratory studies it suggests the need for further research. Currently, a prospective, randomized, blinded, controlled multicenter trial is underway to evaluate the clinical importance of these observations.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA. jmolnar@wfubmc.edu
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Molnar
authors.forename: Jordan L
authors.initials: JL
authors.lastname: Simpson
authors.forename: Denise M
authors.initials: DM
authors.lastname: Voignier
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Morykwas
authors.forename: Louis C
authors.initials: LC
authors.lastname: Argenta