title: Regiospecific synthesis of 4-alkoxy and 4-amino substituted 2-trifluoromethyl pyrroles.
abstract: A simple and regiospecific synthesis of 4-alkoxy(amino)-2-trifluoromethyl pyrroles from 5-azido-4-alkoxy(amino)-1,1,1-trifluoro-pent-3-en-2-ones by an aza-Wittig cyclization of aminophosphoranes is described. The structures of the pyrroles and their synthetic intermediates were supported by NMR and HRMS analysis.
authors.affiliation: Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, CEP-97105-900, Santa Maria, RS, Brazil. zanatta@base.ufsm.br
authors.forename: Nilo
authors.initials: N
authors.lastname: Zanatta
authors.forename: Juliana M F M
authors.initials: JM
authors.lastname: Schneider
authors.forename: Paulo H
authors.initials: PH
authors.lastname: Schneider
authors.forename: Ana D
authors.initials: AD
authors.lastname: Wouters
authors.forename: Helio G
authors.initials: HG
authors.lastname: Bonacorso
authors.forename: Marcos A P
authors.initials: MA
authors.lastname: Martins
authors.forename: Ludger A
authors.initials: LA
authors.lastname: Wessjohann
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006845:Hydrocarbons, Fluorinated; D011758:Pyrroles