Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus.
Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3.
Maloney
Katherine N
KN
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Hao
Wenshan
W
Xu
Jun
J
Gibbons
Jay
J
Hucul
John
J
Roll
Deborah
D
Brady
Sean F
SF
Schroeder
Frank C
FC
Clardy
Jon
J
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005658:Fungi / Q000378:metabolism*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects
D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D006574:Heterocyclic Compounds, 2-Ring; D050796:STAT3 Transcription Factor; C520910:phaeosphaeride A