G-CSF in acute myocardial infarction - experimental and clinical findings.
Early data from clinical studies suggest that intracoronary injection of autologous progenitor cells may beneficially affect postinfarction remodeling and perfusion. Beyond intracoronary infusion of autologous bone marrow mononuclear CD34+ cells (MNCCD34+), mobilization of stem cells by G-CSF has recently attracted attention because of various advantages such as the noninvasive nature of MNCCD34+ mobilization by subcutaneous injections. It is the aim of the present work to give an overview about the current experimental and clinical findings of G-CSF treatment in acute myocardial infarction.
Ince
Hüseyin
H
Department of Medicine, Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Rostock, Germany. hueseyin.ince@med.uni-rostock.de
Petzsch
Michael
M
Rehders
Tim C
TC
Dunkelmann
Simone
S
Nienaber
Christoph A
CA
D015906:Angioplasty, Balloon, Coronary; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007279:Injections, Subcutaneous; D009203:Myocardial Infarction / Q000628:therapy*; D020257:Ventricular Remodeling / Q000187:drug effects*
D016179:Granulocyte Colony-Stimulating Factor