title: Impact of organizational infrastructure on beta-blocker and aspirin therapy for acute myocardial infarction.
abstract: BACKGROUND
  Although organizational change has been advocated as a critical component of quality improvement, there is little data available on the variation and effectiveness of organizational elements in the care of acute myocardial infarction (AMI).
  
  
  OBJECTIVE
  This study was designed to examine the impact of organizational infrastructure on the use of aspirin and beta-blockers during and after AMI.
  
  
  METHODS
  We assessed organizational infrastructure for AMI care in 44 hospitals in Kansas and linked these data to patient-specific process of care data collected in Kansas as part of the Cooperative Cardiovascular Project. While controlling for clustering within hospitals, we examined the relationships between hospital infrastructure and use of aspirin and beta-blocker both at admission and discharge.
  
  
  RESULTS
  Hospitals varied widely in their inclusion of aspirin and beta-blockers in AMI pathways, protocols, and standardized order sets. Hospitals also varied in the involvement of their physicians in AMI quality improvement and in their ability to identify a physician champion for AMI care. Patients were more likely to receive aspirin on admission in hospitals that included aspirin in their emergency department order sets (odds ratio [OR] 1.57, 95% confidence interval [CI] 1.01-2.48) and were more likely to receive beta-blockers on admission and at discharge if beta-blockers were included in an emergency department protocol or pathway (OR 2.14, 95% CI 1.25-3.77 and OR 3.5, 95% CI 1.14-14.38, respectively). Use of beta-blockers at discharge was also associated with commitment of administration to AMI care and the presence of a physician champion.
  
  
  CONCLUSIONS
  Quality improvement efforts should include a close examination of the organization of AMI care to assure that critical elements in the care of AMI patients are not inadvertently omitted.
authors.affiliation: Department of Preventive Medicine, University of Kansas School of Medicine, Kansas City, KS 66160-7313, USA. eellerbe@kumc.edu
authors.forename: Edward F
authors.initials: EF
authors.lastname: Ellerbeck
authors.forename: Arvind
authors.initials: A
authors.lastname: Bhimaraj
authors.forename: Sandra
authors.initials: S
authors.lastname: Hall
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D006739:Hospital Administration / Q000379:methods; D006761:Hospitals; D006801:Humans; D007615:Kansas / Q000453:epidemiology; D016344:Medicare Part A / Q000458:organization & administration*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000453:epidemiology*
chemical_list: D000319:Adrenergic beta-Antagonists; D001241:Aspirin