title: AmBisome treatment of fungal sinusitis in severe immunocompromised patient with acute lymphoblastic leukemia relapsed after autologous peripheral blood transplantation.
abstract: This report describes the case of fungal sinusitis in severely immunocompromised 32-year-old male with common-type acute lymphoblastic leukemia who relapsed after autologous peripheral blood transplantation. Empirical therapy with antibiotics and conventional amphotericin B failed to resolve the infection. Following therapy with AmBisome his symptoms abated and significantly improved scan picture was seen.
authors.affiliation: Department of Hematology and Oncology, Medical University of Warsaw, Poland. mrokicka@amwaw.edu.pl
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Rokicka
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy; D013293:Enterococcus faecalis / Q000302:isolation & purification; D017809:Fatal Outcome; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage / Q000009:adverse effects; D016867:Immunocompromised Host; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008081:Liposomes; D008297:Male; D009181:Mycoses / Q000150:complications / Q000188:drug therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy; D011183:Postoperative Complications / Q000188:drug therapy*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D016958:Pseudomonas putida / Q000302:isolation & purification; D011654:Pulmonary Edema / Q000209:etiology; D011743:Pyrimidines / Q000627:therapeutic use; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D014182:Transplantation, Autologous; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D016756:Immunoglobulins, Intravenous; D008081:Liposomes; D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; D003561:Cytarabine; D000666:Amphotericin B; D065819:Voriconazole; D015255:Idarubicin