[Evaluation of microalbuminuria in non-diabetic individuals].
OBJECTIVE
To evaluate the presence of microalbuminuria in non-diabetic subjects, associating it to the presence of cardiovascular risk factors like hypertension, smoking, dislipidemia and obesity. The urinary albumin excretion rate (UAE) was also evaluated regarding to insulin secretion and resistance indices.


METHODS
105 subjects aged 33.4 +/- 1.4 years (57.1% women), received 75 g dextrose for an OGTT, and the following variables were evaluated for glucose and insulin curves: basal and 2 hours values, peak values (PV) and area under the curves (AUC). To evaluate insulin secretion and resistance, we used the insulinogenic, delta, HOMA, QUICKI, glucose to insulin ratio and the relation between insulinogenic and HOMA indices. A urine sample was collected overnight for albuminuria. Individuals were allocated in two groups: 1) normal, and 2) altered glucose metabolism.


RESULTS
The two groups differed in age, BMI, BP, abdominal circumference (AC), WHR, cholesterol, triglycerides (TG), glycemias (basal and 2h), AUCg, HOMA and QUICKI indices and the relation between insulinogenic and HOMA. Mean UAE was 4.28 +/- 2.73 microg/mL, correlating to DBP, glycemias, AUCg, GPV, HOMA, 2h insulin, IPV e AUCi. By stepwise multiple-regression analysis, only AUCg was predictive of UAE. By comparing interquartile intervals of UAE, we found statistical significance between the 1st and 4th quartile for: BMI, SBP, DBP, AC, waist, 2h glucose, TG, LDL, AUCg, AUCi, GPV and HOMA and QUICKI indices.


CONCLUSIONS
Although in the absence of microalbuminuric individuals, we found differences among UAE in individuals across a range of glucose tolerance and differences between clinical and laboratorial variables in the interquartile analysis. Our findings suggest that in non-diabetic individuals, UAE is associated to some characteristics of the metabolic syndrome, probably predisposing to greater atherogenic susceptibility.
Corrêa
Fernanda H S
FH
Departamento de Medicina Interna, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro 77-A, 20551-030 Rio de Janeiro, RJ.
Nogueira
Verônica G
VG
Clemente
Eliete L S
EL
Bevilácqua
Maria de F
MF
Gomes
Marília de Brito
MB
D000328:Adult; D000367:Age Factors; D000419:Albuminuria / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D005947:Glucose / Q000032:analysis / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000032:analysis*; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D012044:Regression Analysis; D012307:Risk Factors; D049629:Waist-Hip Ratio
D007328:Insulin; D005947:Glucose