[Non-canonical decoding events at stop codons in eukaryotes].
Regulation of protein synthesis at translation termination is a relatively under-explored, but rapidly expanding field. Recent advances in elucidating the mechanism of translation termination are helping to understand non-canonical events associated with translation termination. These "recoding" events include read-through of stop-codons, insertion of unusual amino acids such as selenocysteine and production of several polypeptides from one open reading frame. This review summarises data on termination-dependent recoding events, and proposes that there are two types of stop codon-associated sequences optimized to perform different functions: termination of translation per se or alternative elongation events.
Doronina
Victoria A
VA
Brown
Jeremy D
JD
D000818:Animals; D018388:Codon, Terminator; D005815:Genetic Code; D006801:Humans; D016366:Open Reading Frames; D010443:Peptide Chain Termination, Translational / Q000235:genetics / Q000502:physiology*; D010454:Peptide Termination Factors / Q000235:genetics / Q000502:physiology*; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000502:physiology*; D017279:Selenocysteine / Q000235:genetics
D018388:Codon, Terminator; D010454:Peptide Termination Factors; D017279:Selenocysteine