Brain neurotensin, psychostimulants, and stress--emphasis on neuroanatomical substrates.
Neurotensin (NT) is a peptide that is widely distributed throughout the brain. NT is involved in locomotion, reward, stress and pain modulation, and in the pathophysiology of drug addiction and depression. In its first part this review brings together relevant literature about the neuroanatomy of NT and its receptors. The second part focuses on functional-anatomical interactions between NT, the mesotelencephalic dopamine system and structures targeted by dopaminergic projections. Finally, recent data about the actions of NT in processes underlying behavioral sensitization to psychostimulant drugs and the involvement of NT in the regulation of the hypothalamo-pituitary-adrenal gland axis are considered.
Geisler
Stefanie
S
Department of Pharmacological and Physiological Science, Saint Louis University, School of Medicine, St. Louis, MO 63104, USA.
Bérod
Anne
A
Zahm
Daniel S
DS
Rostène
William
W
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D009496:Neurotensin / Q000235:genetics / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism; D018028:Receptors, Neurotensin / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism
D011619:Psychotropic Drugs; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D018028:Receptors, Neurotensin; D009496:Neurotensin; D004298:Dopamine