title: Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura: a case report.
abstract: A 77-year-old man on systemic chemotherapy against postoperative bilateral multiple lung metastases of malignant solitary fibrous tumor of the pleura suffered from pruritus and jaundice. Blood examination showed elevated levels of hepatobiliary enzymes. Abdominal computed tomography showed a tumor with peripheral enhancement in the pancreatic head, accompanied with the dilatation of intra- and extra-hepatic bile ducts. He was diagnosed as having obstructive jaundice caused by a pancreatic head tumor. The pancreatic head tumor was presumably diagnosed as the metastasis of malignant solitary fibrous tumor of the pleura, because the findings on the pancreatic head tumor on abdominal CT were similar to those on the primary lung lesion of malignant solitary fibrous tumor of the pleura. The pancreatic tumor grew rapidly after the implantation of metallic stent in the inferior part of the common bile duct. The patient died of lymphangitis carcinomatosa of the lungs. Autopsy revealed a tumor that spread from the pancreatic head to the hepatic hilum. Microscopically, spindle-shaped cells exhibiting nuclear atypicality or division together with collagen deposition were observed. Immunohistochemically the pancreatic head tumor cells were negative for staining of alpha-smooth muscle actin (alpha-SMA) or CD117, but positive for vimentin, CD34 and CD99. These findings are consistent with those on malignant solitary fibrous tumor of the pleura. We report the first case of obstructive jaundice caused by a secondary pancreatic tumor from malignant solitary fibrous tumor of the pleura.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Norie
authors.initials: N
authors.lastname: Yamada
authors.forename: Chiaki
authors.initials: C
authors.lastname: Okuse
authors.forename: Masahito
authors.initials: M
authors.lastname: Nomoto
authors.forename: Mayu
authors.initials: M
authors.lastname: Orita
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katakura
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ishii
authors.forename: Takuo
authors.initials: T
authors.lastname: Shinmyo
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Osada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Maeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yotsuyanagi
authors.forename: Michihiro
authors.initials: M
authors.lastname: Suzuki
authors.forename: Fumio
authors.initials: F
authors.lastname: Itoh
mesh_terms: D000368:Aged; D001344:Autopsy; D014408:Biomarkers, Tumor / Q000097:blood; D017809:Fatal Outcome; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology* / Q000473:pathology; D008297:Male; D018218:Neoplasms, Fibrous Tissue / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology / Q000556:secondary*; D010997:Pleural Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor