title: Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy.
abstract: OBJECTIVE
  TRAP220 (thyroid hormone receptor-associated protein) functions as a coactivator for nuclear receptors and stimulates transcription by recruiting the TRAP mediator complex to hormone responsive promoter regions. Thus, TRAP220 enhances the function of thyroid/steroid hormone receptors such as thyroid hormone and oestrogen receptors. This study investigated the expression of TRAP220 mRNA and protein level in epileptic brains comparing with human control.
  
  
  METHODS
  We examined the expression of TRAP220 mRNA and protein levels in temporal lobes from patients with chronic pharmacoresistant epilepsy who have undergone surgery.
  
  
  RESULTS
  Expression of TRAP220 mRNA and protein was shown to be decreased significantly in the temporal cortex of the patients with epilepsy.
  
  
  CONCLUSIONS
  Our work showed that a decrease in TRAP220 mRNA and protein levels may be involved in the pathophysiology of epilepsy and may be associated with impairment of the brain caused by frequent seizures.
authors.affiliation: Neurology Department, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 4000162, China.
authors.forename: Jin-Mei
authors.initials: JM
authors.lastname: Li
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Xi
authors.forename: Yun
authors.initials: Y
authors.lastname: Gong
authors.forename: Feng-Ying
authors.initials: FY
authors.lastname: Liu
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Sun
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wu
authors.forename: Guo-Ming
authors.initials: GM
authors.lastname: Luan
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Li
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Lu
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D015153:Blotting, Western; D002648:Child; D015536:Down-Regulation; D004827:Epilepsy / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D056913:Mediator Complex Subunit 1; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D013702:Temporal Lobe / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: C538855:MED1 protein, human; D056913:Mediator Complex Subunit 1; D012333:RNA, Messenger; D014157:Transcription Factors