title: Subarachnoid hemorrhage is followed by temporomesial volume loss: MRI volumetric study.
abstract: OBJECTIVE
  To assess whether subarachnoid hemorrhage (SAH) and its treatment is followed by volume loss in temporomesial structures.
  
  
  METHODS
  One hundred fifty-five consecutive patients with aneurysmal SAH were randomly assigned to surgical or endovascular treatment. Volumetric MRI was performed in 77 SAH patients with good or moderate clinical outcome 1 year after hemorrhage. A comprehensive neuropsychological test battery was used to evaluate the cognitive performance of the subjects. Thirty healthy individuals were imaged as MRI controls.
  
  
  RESULTS
  The normalized hippocampal (HC) volumes were 24.7/23.7 (right/left), and the amygdaloid (AM) volumes were 21.0/20.5 in the matched control population. In SAH patients, the corresponding volumes were smaller, HC 23.2/21.3 (p = 0.072/0.002) and AM 18.4/18.7 (p = 0.012/0.045). In addition, the AM ipsilateral to the ruptured aneurysm was smaller in patients who had undergone surgical treatment (15.7) vs endovascular treatment (20.3; p < 0.001). Treatment modality did not significantly affect the measured HC volumes. The hippocampal but not amygdaloid volumes correlated with the scores of several neuropsychological tests.
  
  
  CONCLUSIONS
  Subarachnoid hemorrhage and its treatment may be followed by atrophy in temporomesial structures. A clear correlation was demonstrated between neuropsychological performance and reduced temporomesial volumes.
authors.affiliation: Department of Clinical Radiology, Kuopio University Hospital, Kuopio University, Kuopio, Finland. paula.bendel@kuh.fi
authors.forename: P
authors.initials: P
authors.lastname: Bendel
authors.forename: T
authors.initials: T
authors.lastname: Koivisto
authors.forename: T
authors.initials: T
authors.lastname: Hänninen
authors.forename: A
authors.initials: A
authors.lastname: Kolehmainen
authors.forename: M
authors.initials: M
authors.lastname: Könönen
authors.forename: H
authors.initials: H
authors.lastname: Hurskainen
authors.forename: C
authors.initials: C
authors.lastname: Pennanen
authors.forename: R
authors.initials: R
authors.lastname: Vanninen
mesh_terms: D001284:Atrophy / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data; D015994:Incidence; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D013702:Temporal Lobe / Q000473:pathology*; D016896:Treatment Outcome