title: Biliopancreatic diversion: long-term effects on gonadal function in severely obese men.
abstract: BACKGROUND
  This study investigated hormonal parameters of gonadal function in severely obese men before and 1 year after undergoing biliopancreatic diversion (BPD).
  
  
  METHODS
  This observational 1-year postoperative study conducted at medical and surgical clinics at an academic medical center in Italy followed 20 severely obese men age 21 to 63 years, with a mean (+/- standard deviation) body mass index (BMI) of 47.3 +/- 13.1. The following parameters were evaluated: body composition, using body impedance analysis (BIA), and serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone, estradiol 17beta, and leptin.
  
  
  RESULTS
  At a mean 12 +/- 1 months after surgery, the patients showed a significant decrease in weight, from 132.1 +/- 36.9 before surgery to 93.5 +/- 20 kg (P < .0001), and BMI, from 47.3 +/- 13.1 before surgery to 33.5 +/- 7 (P < .0001). LH increased from 2.42 +/- 1.59 to 4.97 +/- 2.6 mIU/ml (P < .0001), FSH increased from 2.85 +/- 1.85 to 4.9 +/- 4.2 mIU/mL (P = .021), and total testosterone increased from subnormal presurgical values to within normal range (2.81 +/- 1.08 to 9.12 +/- 1.37 ng/mL; P < .0001), whereas estradiol 17beta decreased from elevated basal levels of 44.0 +/- 29 to 16.7 +/- 6.9 pg/mL (P < .0001). The basal leptin level dropped from 33.0 +/- 9.23 to 16.6 +/- 5.12 ng/mL (P < .0001), reflecting the decrease in body fat. Subjective improvement in sexual performance was reported by 80% of patients.
  
  
  CONCLUSIONS
  Severe obesity is coupled with some significant alterations of the gonadotropin-testicular axis and estradiol 17beta and leptin blood levels. These derangements were substantially corrected by 1 year after BPD.
authors.affiliation: Department of Internal Medicine, Institute of Medical Pathology, University of Sassari, Sassari, Italy. sealagn@tin.it
authors.forename: Sergio
authors.initials: S
authors.lastname: Alagna
authors.forename: Maria L
authors.initials: ML
authors.lastname: Cossu
authors.forename: Paola
authors.initials: P
authors.lastname: Gallo
authors.forename: Pier L
authors.initials: PL
authors.lastname: Tilocca
authors.forename: Piera
authors.initials: P
authors.lastname: Pileri
authors.forename: Giuliano
authors.initials: G
authors.lastname: Alagna
authors.forename: Paola
authors.initials: P
authors.lastname: Maninchedda
authors.forename: Annalisa L
authors.initials: AL
authors.lastname: Sini
authors.forename: Luca
authors.initials: L
authors.lastname: Pilo
authors.forename: Pier P
authors.initials: PP
authors.lastname: Rovasio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Noya
authors.forename: Antonia
authors.initials: A
authors.lastname: Masala
mesh_terms: D000328:Adult; D015904:Biliopancreatic Diversion; D001823:Body Composition; D015992:Body Mass Index; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery*; D018709:Statistics, Nonparametric
chemical_list: D012739:Gonadal Steroid Hormones