The influence of triethylcitrate on the biological properties of poly (L-lactic-co-glycolic acid) membranes.
Biodegradable polymers have a variety of uses in basic and clinical research, as well as important therapeutic applications. The most commonly used are poly (lactic acid), poly (glycolic acid) and their copolymer, poly (L-lactic-co-glycolic acid) or PLGA. The incorporation of a plasticizer into a polymer can be used to obtain a product with specific properties. In this work, we examined the influence of a plasticizer (triethylcitrate) on the properties of PLGA membrane implants for human clinical uses. Membranes with and without plasticizer were dense and compact and contained no pores. The incorporation of 7% plasticizer enhanced the degradation the polymer when compared to polymer without plasticizer. In membranes without plasticizer, the initiation of degradation was very slow and was seen only 60 days after implantation, should allow the use of this material in the repair of damage tissue. In both cases, macroscopic analysis showed that there was no adhesion of the membrane to capsule fibrous, and this adversely affected preservation of the polymer. With time, the adherence of the polymer to surrounding tissue increased. Overall there was little degradation of membranes without plasticizer compared to those containing plasticizer.
Pietro
L
L
Laboratory of Biomaterials, Faculty of Biology, University Catholic of São Paulo, Sorocaba, SP, Brazil.
Silva
D R M
DR
Alberto-Rincon
M C
MC
Duek
E A R
EA
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D002951:Citrates / Q000737:chemistry*; D005260:Female; D006016:Glycolates / Q000737:chemistry*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D010968:Plasticizers / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001672:Biocompatible Materials; D002951:Citrates; D006016:Glycolates; D010968:Plasticizers; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid