title: Guidelines for severe infections: are they useful?
abstract: OBJECTIVE
  The large variability in clinical practice plus the increasing awareness that certain processes of care are associated with improved medical outcomes has led to the development of clinical practice guidelines in serious infection. The evolution of guidelines and their impact on delivery of care in severe infection is reviewed.
  
  
  RESULTS
  Guidelines development has centered around community- and hospital-acquired pneumonia as well as sepsis. The Institute of Healthcare Improvement has emerged as an international leader in changing healthcare professional behavior to be consistent with clinical recommendations in infection-related morbidity. These educational programs are designed to increase awareness of guidelines recommendations and to optimize their implementation. Change bundles are selected sets of interventions or processes distilled from evidence-based practice guidelines that are likely to improve outcome. As new evidence is published, and as experts ponder how the guidelines should best be expressed in the bundles, the bundles will be adapted to optimize their utility.
  
  
  CONCLUSIONS
  The change bundle approach to performance improvement (guidelines-based) is the key to change in practice. The Surviving Sepsis Campaign/Institute of Healthcare Improvement sepsis change bundles are an excellent example of progress along these lines.
authors.affiliation: Robert Wood Johnson School of Medicine, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper University Hospital, Camden, New Jersey 08103, USA.
authors.forename: Ismail
authors.initials: I
authors.lastname: Cinel
authors.forename: R Phillip
authors.initials: RP
authors.lastname: Dellinger
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D017714:Community-Acquired Infections / Q000188:drug therapy; D003422:Critical Care / Q000592:standards*; D003428:Cross Infection / Q000188:drug therapy; D006801:Humans; D011014:Pneumonia / Q000188:drug therapy; D017410:Practice Guidelines as Topic / Q000592:standards*; D018805:Sepsis / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents