[Use of activated recombinant FVII in the control of haemorrhage following trauma].
Uncontrolled haemorrhage is a major cause of death in trauma patients: sometimes inaccessible to surgery and often associated with coagulopathy. We report a case of severe blunt pelvic trauma associated with suicide. The conventional treatments were unsuccessful and embolization was impossible. The patient required massive blood product transfusion. A 100 microg/kg recombinant activated factor VII dose was infused, twice. After administration of the first dose, the blood requirement decreased dramatically. Further work and trials are required to assess the safety profile and dose regimen for this drug.
Perrier
V
V
Département des urgences, CHU Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.
Morel
N
N
Bernard
J-C
JC
Julliac
B
B
Dewitte
A
A
Pouquet
O
O
Sztark
F
F
Dabadie
P
P
D003029:Coagulants / Q000627:therapeutic use*; D005167:Factor VII / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D013406:Suicide, Attempted
D003029:Coagulants; D011994:Recombinant Proteins; D005167:Factor VII