title: Esterified estrogens combined with methyltestosterone raise intraocular pressure in postmenopausal women.
abstract: OBJECTIVE
  To investigate the effect of esterified estrogens combined with methyltestosterone (EECM) (Estratest, Solvay, Pharmaceuticals, Inc, Baudette, Minnesota, USA) on intraocular pressure (IOP) in postmenopausal women.
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  The IOP of 13 consecutive postmenopausal women with dry eye syndrome were recorded before and during EECM therapy (1.25 mg of esterified estrogens and 2.5 mg of methyltestosterone for several months).
  
  
  RESULTS
  The mean IOP increased from a baseline of 15.0 mm Hg before treatment to 18.2 mm Hg on EECM therapy (P < .0001) after a median duration of 11.3 months (range, 0.9 to 24 months). The increase in IOP was statistically significant at the 0.05 level of significance within three months and continued over 12 months. Two patients whose pressures increased (>4 mm Hg) returned to baseline levels after EECM was discontinued.
  
  
  CONCLUSIONS
  Esterified estrogens combined with methyltestosterone produce a clinically significant increase in IOP in postmenopausal women with dry eye syndrome.
authors.affiliation: Ocular Surface Center, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
authors.forename: Rahul N
authors.initials: RN
authors.lastname: Khurana
authors.forename: Laurie D
authors.initials: LD
authors.lastname: LaBree
authors.forename: Garrett
authors.initials: G
authors.lastname: Scott
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Smith
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Yiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015352:Dry Eye Syndromes / Q000150:complications; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000009:adverse effects*; D042724:Estrogens, Esterified (USP) / Q000009:adverse effects; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008777:Methyltestosterone / Q000009:adverse effects*; D008875:Middle Aged; D017698:Postmenopause; D012189:Retrospective Studies; D014065:Tonometry, Ocular
chemical_list: C084327:Estratest-HS; D004967:Estrogens; D042724:Estrogens, Esterified (USP); D008777:Methyltestosterone