Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole.
This report describes the use of bicalutamide and anastrozole in two subjects with familial male-limited precocious puberty. Clinical improvements include decreased facial acne and pubic hair. Most importantly, a marked decrease in growth velocity and skeletal advancement has been achieved.
Kreher
Nerissa C
NC
Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA. nerissa.kreher@serono.com
Pescovitz
Ora Hirsch
OH
Delameter
Paul
P
Tiulpakov
Anatoly
A
Hochberg
Ze'ev
Z
D000077384:Anastrozole; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000813:Anilides / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D009570:Nitriles / Q000627:therapeutic use*; D011629:Puberty, Precocious / Q000188:drug therapy* / Q000235:genetics; D011974:Receptors, LH / Q000235:genetics; D014105:Tosyl Compounds; D014230:Triazoles / Q000627:therapeutic use*
D000726:Androgen Antagonists; D000813:Anilides; D047072:Aromatase Inhibitors; D009570:Nitriles; D011974:Receptors, LH; D014105:Tosyl Compounds; D014230:Triazoles; D000077384:Anastrozole; C053541:bicalutamide