An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum.
A fusidane triterpene, 16-deacetoxy-7-beta-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all (1)H and (13)C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 microg/ml.
Evans
Liam
L
Hypha Discovery Ltd., School of Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK.
Hedger
John N
JN
Brayford
David
D
Stavri
Michael
M
Smith
Eileen
E
O'Donnell
Gemma
G
Gray
Alexander I
AI
Griffith
Gareth W
GW
Gibbons
Simon
S
D000164:Acremonium / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial; D005672:Fusidic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C516014:16-deacetoxy-7-beta-hydroxy-fusidic acid; D000900:Anti-Bacterial Agents; D014315:Triterpenes; D005672:Fusidic Acid