In vivo reversion to the wild-type beta-lactam resistance phenotype mediated by a plasmid carrying ampR and qnrA1 in Enterobacter cloacae.
Resistance to beta-lactams and quinolones in two isogenic Enterobacter cloacae isolates was studied. One was susceptible to cefoxitin and amoxicillin-clavulanate. The other one showed its natural beta-lactam resistance pattern. Both isolates had a nonfunctional AmpR regulator. However, within the second one, the presence of a plasmid carrying ampR and qnrA1 allowed reversion to the wild-type beta-lactam resistance phenotype and decreased susceptibility to fluoroquinolones.
González-López
J J
JJ
Servicio de Microbiología, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
Sabaté
M
M
Lavilla
S
S
Larrosa
M N
MN
Bartolomé
R M
RM
Prats
G
G
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D002440:Cefoxitin / Q000494:pharmacology; D016972:Enterobacter cloacae / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction; D015363:Quinolones / Q000494:pharmacology; D018440:beta-Lactam Resistance / Q000235:genetics*
D001426:Bacterial Proteins; D015363:Quinolones; C071526:AmpR protein, Bacteria; D002440:Cefoxitin; D019980:Amoxicillin-Potassium Clavulanate Combination