Oxidants and antioxidants in disease: oxidative stress in farm animals.
Important infectious diseases in farm animals, such as pneumonia and enteritis, are thought to be associated with the so-called oxidative stress, i.e. a chemical phenomenon involving an imbalance in the redox status of the individual animal. The specifics of oxidative stress and how it may result in disease or be prevented are complex questions with no simple answers. However, the considerable literature on the subject suggests that many researchers consider oxidative stress-related mechanisms to be important early events in disease development. A particularly intriguing aspect is that, at least theoretically, oxidative stress should be easily prevented with antioxidants yet the use of antioxidants as therapy remains controversial. The present knowledge on oxidative stress in farm animals is the topic of this review.
Lykkesfeldt
Jens
J
Section of Biomedicine, Department of Veterinary Pathobiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark. jopl@kvl.dk
Svendsen
Ove
O
D000818:Animals; D000829:Animals, Domestic; D000975:Antioxidants / Q000378:metabolism*; D002417:Cattle; D004249:DNA Damage; D006736:Horses; D007239:Infections / Q000378:metabolism / Q000662:veterinary*; D016877:Oxidants / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013552:Swine
D000975:Antioxidants; D016877:Oxidants