Development and research in idiopathic thrombocytopenic purpura: an inflammatory and autoimmune disorder.
Bleeding and isolated thrombocytopenia in idiopathic thrombocytopenic purpura (ITP) are phenomena of a transient or long-term disturbed immune response. Since 1980, ITP has become a model for targeted therapeutic immunomodulation with still unclear mechanisms of action. The systematic analysis of ITP aims to determine more clearly defined patient subgroups for targeted therapy and to explore the complex immune disturbances in this autoimmune disorder.
Imbach
Paul
P
University Children's Hospital Basel, Pediatric Oncology/Hematology, Basel, Switzerland. paul.imbach@unibas.ch
D001327:Autoimmune Diseases / Q000276:immunology*; D035843:Biomedical Research / Q000639:trends*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy