title: Accuracy of transcranial Doppler sonography for predicting cerebral infarction in aneurysmal subarachnoid hemorrhage.
abstract: OBJECTIVE
  To evaluate the accuracy of transcranial Doppler (TCD) sonography using different criteria for predicting cerebral infarction due to symptomatic vasospasm.
  
  
  METHODS
  We retrospectively evaluated the clinical and radiologic data of consecutive patients admitted with acute aneurysmal subarachnoid hemorrhage (SAH) in the anterior cerebral circulation between January 2001 and June 2002. TCD sonographic examinations were performed on alternate days up to 20 days after admission. Cerebral infarction was defined on CT as a new hypodensity in the vascular distribution with corresponding clinical symptoms. Vasospasm was diagnosed as mild or severe when TCD sonography revealed a mean blood flow velocity (MBFV) greater than 120 and 180 cm/s in the middle or anterior cerebral artery and in the intracranial part of the internal carotid artery, respectively.
  
  
  RESULTS
  A total of 93 patients with aneurysmal SAH in the anterior cerebral circulation were included. Vasospasm was demonstrated by TCD sonography in 60 patients (64.5%) and was shown via multivariable logistic regression analysis to be predictive of cerebral infarction (OR 3.11, 95% CI 1.46-6.59), with an 82.6% and 69.6% sensitivity, a 41.4% and 77.1% specificity, a 31.7% and 50.0% positive predictive value, and an 87.9% and 88.5% negative predictive value when the MBFV was greater than 120 and 180 cm/s, respectively.
  
  
  CONCLUSIONS
  Vasospasm on TCD was found to be predictive of symptomatic cerebral infarction on CT, but its positive predictive value remained low despite the adoption of restrictive TCD criteria for vasospasm.
authors.affiliation: Department of Neurology, Yonsei University Wonju College of Medicine, Ilsan-dong 162, Wonju, Gangwon-do, 220-701, Korea.
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Lee
authors.forename: Myeong Sub
authors.initials: MS
authors.lastname: Lee
authors.forename: Kum
authors.initials: K
authors.lastname: Whang
authors.forename: Jai Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Seo-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000209:etiology*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging; D017585:Ultrasonography, Doppler, Transcranial