title: The plasma levels of soluble P-selectin in subjects with prediabetes.
abstract: Prediabetes has been associated with an increased risk of cardiovascular disease and mortality. Soluble P-selectin (sP-selectin) is an index of platelet activation and also a risk factor for future vascular events. sP-selectin levels were investigated in prediabetic subjects who had no confounding factors such as hypertension, obesity or dyslipidaemia. sP-selectin, hsCRP levels and HOMA-IR indexes were measured in 40 prediabetic subjects (n = 24 for IFG and n = 16 for IGT) and age-, sex- and BMI-matched 40 healthy controls. sP-selectin levels in prediabetic subjects were not significantly different compared with those in controls (p = 0.12). Prediabetic group had similar hsCRP (p = 0.29), higher HOMA-IR indexes (p < 0.001) and lower HDL cholesterol levels (p = 0.001) when compared with healthy controls. The power of the study was 0.93 for sP-selectin, 0.7 for hsCRP and 1.0 for HOMA. Our data suggest that sP-selectin may not contribute to the prothrombotic state as well as the accelerated atherogenesis associated with prediabetes.
authors.affiliation: Department of Internal Medicine, Gulhance School of Medicine, Etlik, Ankara, Turkey. teomandogru@yahoo.com
authors.forename: T
authors.initials: T
authors.lastname: Dogru
authors.forename: I
authors.initials: I
authors.lastname: Tasci
authors.forename: A
authors.initials: A
authors.lastname: Sonmez
authors.forename: H
authors.initials: H
authors.lastname: Genc
authors.forename: M
authors.initials: M
authors.lastname: Gok
authors.forename: M I
authors.initials: MI
authors.lastname: Yilmaz
authors.forename: A U
authors.initials: AU
authors.lastname: Ural
authors.forename: A
authors.initials: A
authors.lastname: Olgun
authors.forename: S
authors.initials: S
authors.lastname: Kilic
authors.forename: E
authors.initials: E
authors.lastname: Bozoglu
authors.forename: G
authors.initials: G
authors.lastname: Erdem
authors.forename: K
authors.initials: K
authors.lastname: Erbil
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D011236:Prediabetic State / Q000097:blood*; D012307:Risk Factors
chemical_list: D019007:P-Selectin; D002097:C-Reactive Protein