A single dose of sulthiame induces a selective increase in resting motor threshold in human motor cortex: A transcranial magnetic stimulation study.
Sulthiame is a carbonic anhydrase inhibitor that is widely used to treat partial and myoclonic seizures. In 11 healthy adults, we applied transcranial magnetic stimulation (TMS) to the primary motor cortex. Using a cross-over study design, we found that a single oral dose of sulthiame (5 mg/kg) produced a significant increase of resting motor threshold relative to placebo. No other TMS measure of corticomotor excitability was altered after a single dose of sulthiame. The selective increase in motor threshold suggests that sulthiame produces its antiepileptic effect by reducing the axonal excitability of cortical neurons.
Siniatchkin
Michael
M
Neuropediatric Department, Christian-Albrechts-University, Kiel, Germany. m.siniatchkin@pedneuro.uni-kiel.de
Groppa
Sergey
S
Siebner
Hartwig
H
Stephani
Ulrich
U
D000284:Administration, Oral; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D013843:Thiazines / Q000008:administration & dosage / Q000494:pharmacology*; D050781:Transcranial Magnetic Stimulation; D000096926:Benzenesulfonamides
D000927:Anticonvulsants; D013843:Thiazines; C084593:sulthiame; D000096926:Benzenesulfonamides