Cardiac resynchronisation therapy for heart failure.
Cardiac resynchronisation therapy (CRT) reduces symptoms and improves left ventricular function in chronic heart failure (CHF) patients with left ventricular systolic dysfunction and prolonged QRS duration. Recent studies have demonstrated a reduction in mortality associated with CRT. When combined with an implantable cardioverter defibrillator (ICD) reduction in mortality is likely to reduce further. Cardiac resynchronisation therapy is well tolerated and free from compliance issues and therefore should be considered for all suitable patients. Identifying patients who will derive maximum benefit requires further study and has health economic implications. We review here the CRT trial evidence as well as the implantation technique and complications. We also describe a case report where an intra-aortic balloon pump was used successfully as a bridge to CRT to treat a patient with end-stage heart failure.
Behan
M W H
MW
Cardiothoracic Department, St Thomas' Hospital, Guy's and St Thomas' NHS Trust, London SE1 7EH, UK.
Rinaldi
C A
CA
D000368:Aged; D001281:Atrial Fibrillation / Q000628:therapy; D002304:Cardiac Pacing, Artificial / Q000191:economics / Q000379:methods* / Q000401:mortality; D002986:Clinical Trials as Topic; D006327:Heart Block / Q000628:therapy; D006333:Heart Failure / Q000191:economics / Q000401:mortality / Q000628:therapy*; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial / Q000191:economics; D019919:Prosthesis Implantation