title: Topical mitomycin-C for obstructing endobronchial granuloma.
abstract: An elderly woman with post-tuberculous stricture of the lower trachea and main bronchi underwent laser re-canalization, balloon dilation, and silicone stent insertion in the lower trachea and main bronchi. Subsequently she had recurrent dyspnea develop due to obstructing granulomas, which necessitated four endoscopic procedures in 2 years. The tracheal stent was removed and topical mitomycin-C was applied using saturated pledgets at a dose of 0.5 mg/mL for 2 minutes each over the lower trachea and both orifices of the main bronchi. Follow-up for 24 months showed no recurrence of symptoms. Bronchoscopy and spirometry performed at 2, 6, and 12 months showed resolution of the granulomas.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
authors.forename: Alvin
authors.initials: A
authors.lastname: Penafiel
authors.forename: Pyng
authors.initials: P
authors.lastname: Lee
authors.forename: Anne
authors.initials: A
authors.lastname: Hsu
authors.forename: Philip
authors.initials: P
authors.lastname: Eng
mesh_terms: D000287:Administration, Topical; D000368:Aged; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D001999:Bronchoscopy; D002404:Catheterization; D003131:Combined Modality Therapy; D004417:Dyspnea / Q000209:etiology; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D006131:Growth Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy; D016685:Mitomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy* / Q000601:surgery; D015607:Stents; D014133:Tracheal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D014135:Tracheal Stenosis / Q000209:etiology / Q000601:surgery; D014397:Tuberculosis, Pulmonary / Q000150:complications; D014797:Vital Capacity
chemical_list: D006131:Growth Inhibitors; D016685:Mitomycin