title: A case of mucin producing liver metastases with intrabiliary extension.
abstract: A 75-year-old man was admitted to our hospital with a diagnosis of liver metastases from colon cancer. He underwent right hemicolectomy for cecal cancer eight years ago, and had a metastatic liver tumor in segment 8 (S8), which was surgically resected about 4 years after the initial operation. Histopathological examination of the resected specimens from both operations revealed a well-differentiated adenocarcinoma with mucinous carcinoma. Four months after the second operation, computed tomography demonstrated a low-density lesion at the cut surface of the remnant liver. Although it was considered to be a postoperative collection of inflammatory fluid, it formed a cystic configuration and increased in size to approximately 5 cm in diameter. With a tentative diagnosis of a recurrence of metastatic cancer, partial hepatectomy of S8 was performed. Histological examination of the resected specimens also revealed mucinous adenocarcinoma, which had invaded into the biliary ducts, replacing and extending along its epithelium. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 20, but negative for CK7. Therefore, the tumor was diagnosed as a metastatic adenocarcinoma from colonic cancer. Liver metastases of colorectal adenocarcinoma sometimes invade the Glisson's triad and grow along the biliary ducts.
authors.affiliation: Department of Transplantation and Digestive Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8051, Japan. h-tokai@cj8.so-net.ne.jp
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tokai
authors.forename: Yujo
authors.initials: Y
authors.lastname: Kawashita
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kamohara
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Takatsuki
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Okudaira
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Tajima
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D000368:Aged; D001650:Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary*; D003110:Colonic Neoplasms / Q000473:pathology* / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary*; D008297:Male; D009077:Mucins / Q000378:metabolism*; D009362:Neoplasm Metastasis
chemical_list: D009077:Mucins