title: [Viscoelastic and functional similarities between native femoral arteries and fresh or cryopreserved arterial and venous homografts].
abstract: OBJECTIVE
  It is not yet known whether cryopreservation enables vessels to retain their viscoelastic properties or whether cryopreserved homografts are biomechanically more like native arteries than currently used vascular prostheses. The study objectives were: a) to determine whether our cryopreservation methodology enables arterial and venous homografts to retain their viscoelastic and functional properties; and b) to assess similarities between patients' femoral arteries, homografts, and other vascular prostheses in common use.
  
  
  METHODS
  The pressure and the diameter and parietal thickness of 15 muscular (femoral) arteries were measured in patients using tonometry and echography, both noninvasive techniques. In addition, the pressure in and diameter and parietal thickness of 15 fresh and 15 cryopreserved human muscular (femoral) artery segments, saphenous veins, and 15 expanded polytetrafluoroethylene (ePTFE) vascular prostheses were measured in vitro under hemodynamic conditions similar to those in patients. A Kelvin-Voigt model of the segment wall was used to derive elastic (Epd, mm Hg/mm) and viscous (Vpd, mm Hg x s/mm) pressure-diameter indices, the buffering function (Vpd/Epd), and the conduit function (1/Zc, where Zc is the characteristic impedance). The incremental Young modulus, the pressure-strain elastic modulus, and pulse wave velocity were also calculated.
  
  
  RESULTS
  No difference was observed between either the viscoelastic or functional properties of fresh and cryopreserved homografts. Arterial homografts were the most similar to the patient's arteries.
  
  
  CONCLUSIONS
  Cryopreservation enabled venous and arterial homografts to retain their viscoelastic and functional properties. Of all the grafts investigated, arterial homografts were most similar, both biomechanically and functionally, to the patient's femoral arteries.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. dbia@fmed.edu.uy
authors.forename: Daniel
authors.initials: D
authors.lastname: Bia
authors.forename: Yanina
authors.initials: Y
authors.lastname: Zócalo
authors.forename: Franco
authors.initials: F
authors.lastname: Pessana
authors.forename: Ricardo
authors.initials: R
authors.lastname: Armentano
authors.forename: Héctor
authors.initials: H
authors.lastname: Pérez
authors.forename: Edmundo
authors.initials: E
authors.lastname: Cabrera
authors.forename: María
authors.initials: M
authors.lastname: Saldías
authors.forename: Inés
authors.initials: I
authors.lastname: Alvarez
mesh_terms: D001808:Blood Vessels / Q000637:transplantation*; D015925:Cryopreservation / Q000379:methods*; D004548:Elasticity; D005263:Femoral Artery / Q000502:physiology*; D006801:Humans; D014783:Viscosity