Hepatic focal nodular hyperplasia developing in a Fanconi anemia patient: a case report and literature review.
Fanconi anemia, an autosomal recessive and X-linked disorder, is known to be associated with a variety of neoplasms. Liver tumors are one of the most frequently observed neoplasms but the association between the two disorders remains obscure. We present a case of a 27-year old female Fanconi anemia patient diagnosed with a mass on the right lobe of the liver measuring 90x75x60 mm. Histopathological examination of the mass after right hepatic lobectomy revealed focal nodular hyperplasia. This appears to be the first reported case of a hepatic focal nodular hyperplasia of such proportion associated with Fanconi anemia. Previously reported cases of liver tumors in association with Fanconi anemia in the English Literature were either hepatocellular carcinomas or hepatic adenomas.
Nuamah
Nabil M
NM
Hacettepe University School Of Medicine, Department of General Surgery, Sihhiye, Ankara 06100 Turkey. Drnuamah@Yahoo.Com
Hamaloglu
Erhan
E
Ozdemir
Arif
A
Ozenc
Ahmet
A
Sozseker
Chava
C
Sokmensuer
Cenk
C
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000601:surgery; D005199:Fanconi Anemia / Q000150:complications*; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000601:surgery; D012196:Review Literature as Topic