The relation of amino-terminal propeptide of type III procollagen and severity of coronary artery disease in patients without myocardial infarction or hibernation.
OBJECTIVE
The association of cardiac fibrosis and coronary artery disease (CAD) in patients without infarction or hibernation is unclear. We investigated the relationship between serum concentrations of procollagen propeptides and severity of CAD in such patients.


METHODS
Forty-six patients (32 men; mean age 64 years) with chest pain were enrolled. All patients received stress thallium-201 single photon emission computed tomography (SPECT) and analysis of the serum levels of the amino-terminal propeptide of type I and III procollagen (PINP and PIIINP).


RESULTS
In patients with thallium-201 perfusion defects, the number of diseased vessels was associated significantly with PIIINP (p=0.024) rather than PINP (p=0.613). Follow-up serum PINP and PIIINP levels after coronary intervention (mean 84 days) revealed no significant decrease.


CONCLUSIONS
Serum PIIINP level is significantly associated with the severity of CAD in patients without myocardial infarction or hibernation.
Lin
Yen-Hung
YH
Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
Ho
Yi-Lwun
YL
Wang
Tzung-Dau
TD
Liu
Chung-Pin
CP
Kao
Hsien-Li
HL
Chao
Chia-Lun
CL
Chien
Kuo-Liong
KL
Hung
Chi-Sheng
CS
Wu
Vin-Cent
VC
Tsai
I-Jung
IJ
Yen
Ruoh-Fang
RF
Shiau
Yu-Chien
YC
Chen
Wen-Jone
WJ
D000368:Aged; D015415:Biomarkers / Q000032:analysis; D006328:Cardiac Catheterization; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D003331:Coronary Vessels / Q000737:chemistry; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D015425:Myocardial Reperfusion; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; D013794:Thallium Radioisotopes; C047202:procollagen Type I N-terminal peptide; C041876:procollagen Type III-N-terminal peptide