The trifecta of aging in Caenorhabditis elegans.
Insulin signaling, mitochondrial respiration, and dietary restriction share conserved roles not only in the regulation of lifespan, but also in the timing and control of diverse functions such as reproduction, stress resistance and metabolism. These autonomous pathways differ in their dependence on known transcription factors and in their temporal requirements, but converge to manipulate the core set of physiological systems necessary for extended lifespan in worms. Recent work suggests that components of these pleiotrophic pathways might be manipulated specifically for their effects on aging without affecting additional downstream functions. Examination of these findings will help us to understand how the molecular mechanisms of distinct pathways can unite in the regulation of longevity.
Wolff
Suzanne
S
The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Dillin
Andrew
A
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics; D004032:Diet; D051858:Forkhead Transcription Factors; D017238:Genes, Helminth / Q000235:genetics; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008136:Longevity / Q000502:physiology; D053858:Metabolic Networks and Pathways; D008928:Mitochondria / Q000502:physiology; D023421:Models, Animal; D008957:Models, Genetic; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics
D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D007328:Insulin; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; D007334:Insulin-Like Growth Factor I