Evidence for stroke-induced neurogenesis in the human brain.
Experimental stroke in rodents stimulates neurogenesis and migration of newborn neurons from their sites of origin into ischemic brain regions. We report that in patients with stroke, cells that express markers associated with newborn neurons are present in the ischemic penumbra surrounding cerebral cortical infarcts, where these cells are preferentially localized in the vicinity of blood vessels. These findings suggest that stroke-induced compensatory neurogenesis may occur in the human brain, where it could contribute to postischemic recovery and represent a target for stroke therapy.
Jin
Kunlin
K
Buck Institute for Age Research, Novato, CA 94945, USA.
Wang
Xiaomei
X
Xie
Lin
L
Mao
Xiao Ou
XO
Zhu
Wei
W
Wang
Yin
Y
Shen
Jianfeng
J
Mao
Ying
Y
Banwait
Surita
S
Greenberg
David A
DA
D000328:Adult; D000368:Aged; D002545:Brain Ischemia; D002454:Cell Differentiation; D049109:Cell Proliferation; D002540:Cerebral Cortex / Q000166:cytology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000166:cytology*; D020521:Stroke / Q000473:pathology* / Q000503:physiopathology*