title: Epibatidine isomers and analogues: structure-activity relationships.
abstract: Binding affinities for a range of epibatidine isomers and analogues at the alpha4beta2 and alpha3beta4 nAChR subtypes are reported; compounds having similar N-N distances to epibatidine show similar, high potencies.
authors.affiliation: Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: White
authors.forename: John R
authors.initials: JR
authors.lastname: Malpass
authors.forename: Sandeep
authors.initials: S
authors.lastname: Handa
authors.forename: S
authors.initials: S
authors.lastname: Richard Baker
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Broad
authors.forename: Liz
authors.initials: L
authors.lastname: Folly
authors.forename: Adrian
authors.initials: A
authors.lastname: Mogg
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D007536:Isomerism; D018722:Nicotinic Agonists / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D018722:Nicotinic Agonists; D011725:Pyridines; C082748:epibatidine