title: Role of P glycoprotein in absorption of novel antimalarial drugs.
abstract: Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 microM) and low for naphthoquine (5 microM). With 20 microM naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.
authors.affiliation: Curtin University of Technology, School of Pharmacy, Perth, Western Australia, Australia. A.P.Crowe@curtin.edu.au
authors.forename: Andrew
authors.initials: A
authors.lastname: Crowe
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Ilett
authors.forename: Harin A
authors.initials: HA
authors.lastname: Karunajeewa
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Batty
authors.forename: Timothy M E
authors.initials: TM
authors.lastname: Davis
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000962:Antimalarials / Q000378:metabolism*; D001692:Biological Transport; D018938:Caco-2 Cells / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D009287:Naphthyridines / Q000378:metabolism
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000962:Antimalarials; D009287:Naphthyridines; C027871:pyronaridine