Interactions between neurotensin receptors and G proteins.
Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towards all NTS1-mediated pathways, this peptide may exert either agonist or antagonist activities, depending on the NTS2-mediated pathway in question. Studies on these receptors reinforce the concept of independence between multiple signals potentially mediated through a single GPCR, generating a wide diversity of functional responses depending on the host cell and the ligand.
Pelaprat
Didier
D
INSERM, U.773, CRB3, EA 3512, Faculté de Médecine Xavier Bichat, 16 rue Henri Huchard, BP416, 75870 Paris Cedex 18, France. pelaprat@bichat.inserm.fr
D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D008959:Models, Neurological; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000502:physiology; D018028:Receptors, Neurotensin / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
D043562:Receptors, G-Protein-Coupled; D018028:Receptors, Neurotensin; D019204:GTP-Binding Proteins