title: Allergy-preventive phenolic glycosides from Populus sieboldii.
abstract: Allergy-preventive activity was demonstrated for an extract of the bark of Populus sieboldii in a continuing search for allergy-preventive substances from natural sources. By bioassay-directed fractionation of this plant bark, two new phenolic glycosides, siebolside A {2-hydroxy-5-[(benzoyloxy)methyl]phenyl (6'-O-acetyl) beta-D-glucopyranoside} (1) and siebolside B {2-hydroxy-5-[(benzoyloxy)methyl]phenyl beta-D-glucopyranoside} (2), were isolated, together with three known compounds, salicin (3), sakuranin (4), and neosakuranin (5). The structures of 1 and 2 were elucidated by spectroscopic methods. Compounds 1-5 all showed allergy-preventive effects.
authors.affiliation: School of Pharmaceutical Sciences, Mukogawa Women's University, Koshien Kyuban-cho, Nishinomiya, 663-8179, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Hisae
authors.initials: H
authors.lastname: Oku
authors.forename: Emiko
authors.initials: E
authors.lastname: Iwaoka
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ishiguro
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D005960:Glucosides; D006027:Glycosides / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006967:Hypersensitivity / Q000517:prevention & control*; D007564:Japan; D051379:Mice; D015394:Molecular Structure; D010636:Phenols / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D032107:Populus / Q000737:chemistry*
chemical_list: D005960:Glucosides; D006027:Glycosides; D010636:Phenols; C513725:siebolside A; C513727:siebolside B