title: Hypophosphatemia: an evidence-based approach to its clinical consequences and management.
abstract: Optimal cellular function is dependent on maintenance of a normal serum phosphorus concentration. Serum phosphorus concentration is affected by several determinants, the most important of which is regulation of phosphorus reabsorption by the kidney. The majority of this reabsorption (80%) occurs in the proximal tubule and is mediated by an isoform of the sodium-phosphate cotransporter (NaPi-II). Parathyroid hormone, via a variety of intracellular signaling cascades leading to NaPi-IIa internalization and downregulation, is the main regulator of renal phosphate reabsorption. Shift of phosphorus from extracellular to intracellular compartments, decreased gastrointestinal absorption, and increased urinary losses, are the primary mechanisms of hypophosphatemia, which affects approximately 2% of hospitalized patients. Hypophosphatemia has been implicated as a cause of rhabdomyolysis, respiratory failure, hemolysis and left ventricular dysfunction. With the exception of ventilated patients, there is little evidence that moderate hypophosphatemia has significant clinical consequences in humans, and aggressive intravenous phosphate replacement is unnecessary. By contrast, patients with severe hypophosphatemia should be treated. Intravenous repletion may be considered, especially for patients who have clinical sequelae of hypophosphatemia.
authors.affiliation: Section of Nephrology at Veterans Affairs North Texas Health Care System, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. jamshid.amanzadeh@utsouthwestern.edu
authors.forename: Jamshid
authors.initials: J
authors.lastname: Amanzadeh
authors.forename: Robert F
authors.initials: RF
authors.lastname: Reilly
mesh_terms: D009202:Cardiomyopathies / Q000209:etiology; D002493:Central Nervous System Diseases / Q000209:etiology; D016883:Diabetic Ketoacidosis / Q000209:etiology; D006461:Hemolysis; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D017674:Hypophosphatemia / Q000150:complications* / Q000209:etiology / Q000628:therapy*; D007668:Kidney / Q000502:physiology; D007960:Leukocyte Disorders / Q000209:etiology; D010710:Phosphates / Q000502:physiology / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use; D012131:Respiratory Insufficiency / Q000209:etiology; D012206:Rhabdomyolysis / Q000209:etiology
chemical_list: D010710:Phosphates; D017680:Potassium Compounds; C013216:potassium phosphate