The role of tetrahydrobiopterin in catalysis by nitric oxide synthase.
Electronic structure calculations show that the cofactor H4B can be a key factor in a proton transfer relay in nitric oxide synthase, and that 4-amino-H4B cannot fulfill this role.
Morao
Inaki
I
School of Chemistry, University of Manchester, Manchester, UK.
Periyasamy
Ganga
G
Hillier
Ian H
IH
Joule
John A
JA
D000465:Algorithms; D001120:Arginine / Q000378:metabolism; D001665:Binding Sites; D001708:Biopterins / Q000031:analogs & derivatives* / Q000494:pharmacology; D002384:Catalysis; D004579:Electron Transport; D006418:Heme / Q000378:metabolism; D015394:Molecular Structure; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D011522:Protons
D011522:Protons; D001708:Biopterins; D006418:Heme; D001120:Arginine; D019001:Nitric Oxide Synthase; C003402:sapropterin