Diabetes-induced decrease in renal oxygen tension: effects of an altered metabolism.
During conditions with experimental diabetes mellitus, it is evident that several alterations in renal oxygen metabolism occur, including increased mitochondrial respiration and increased lactate accumulation in the renal tissue. Consequently, these alterations will contribute to decrease the interstitial pO2, preferentially in the renal medulla of animals with sustained long-term hyperglycemia.
Palm
Fredrik
F
Department of Medical Cell Biology, Uppsala University, Biomedical Center, box 571, SE 751 23 Uppsala, Sweden.
Carlsson
Per-Ola
PO
Fasching
Angelica
A
Hansell
Peter
P
Liss
Per
P
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology