title: Comparison of butyl-2-cyanoacrylate, gelatin-resorcin-formaldehyde (GRF) compound and suture in stabilization of cartilage grafts in rabbits.
abstract: Cartilage grafting is an interesting option for rhinoplasties refinements.
  
  
  OBJECTIVE
  To compare butyl-2-cyanoacrylate, compound gelatin-resorcin-formaldehyde (GRF) and suture control to determine the efficacy of these tissue glue preparations in securing grafted cartilage.
  
  
  METHODS
  Experimental.
  
  
  METHODS
  Fifteen male adult New Zealand rabbits were submitted to a surgical procedure to harvest 6 auricular cartilage grafts from each animal. 2 of these grafts in each animal were glued together with butyl-2-cyanoacrylate, 2 with compound gelatin-resorcin-formaldehyde and 2 sewn together with nylon suture. These sandwich grafts were then glued or sewn to the periosteum of the calvaria. After 2, 6 and 12 weeks, groups of 5 animals were sacrificed and histological analysis for inflammation was performed. Cartilage graft migration, adhesion and deformities of the grafts were also evaluated.
  
  
  RESULTS
  There was less migration of the cartilages glued with GRF than with cyanoacrylate and suture. There was no statistical difference between the 3 materials of graft stabilization in relation to the inflammatory reaction in all evaluated periods. There wasn't detachment neither deformity in the cartilage sandwiches sewn with suture. The majority of detachment and deformed cartilages were found among those glued with cyanoacrylate. The number of deformed cartilages was directly related to the number of detached cartilages. The data were statistically significant (p< 0.05).
  
  
  CONCLUSIONS
  The compound gelatin-resorcin-formaldehyde revealed to be a stabilization material for cartilage grafts in rabbits better than butyl-2-cyanoacrylate. The compound gelatin-resorcin-formaldehyde was also better than the suture when comparing its fixation to the periosteum.
authors.affiliation: FCM Santa Casa de São Paulo, Brazil.
authors.forename: Heloisa Juliana Zabeu Rossi
authors.initials: HJ
authors.lastname: Costa
authors.forename: Celina Siqueira Barbosa
authors.initials: CS
authors.lastname: Pereira
authors.forename: Márcio Paulino
authors.initials: MP
authors.lastname: Costa
authors.forename: Fabrício Sanchez Soga Sanches
authors.initials: FS
authors.lastname: Fabri
authors.forename: Carmen Lúcia Penteado
authors.initials: CL
authors.lastname: Lancellotti
authors.forename: José Eduardo Lutaif
authors.initials: JE
authors.lastname: Dolci
mesh_terms: D000818:Animals; D004338:Drug Combinations; D004425:Ear Cartilage / Q000473:pathology / Q000637:transplantation*; D004659:Enbucrilate / Q000627:therapeutic use*; D005557:Formaldehyde / Q000627:therapeutic use*; D005780:Gelatin / Q000627:therapeutic use*; D006085:Graft Survival; D008297:Male; D011817:Rabbits; D012118:Resorcinols / Q000627:therapeutic use*; D013536:Suture Techniques; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin; D004659:Enbucrilate