title: Exposure of BEAS-2B cells to secondary organic aerosol coated on magnetic nanoparticles.
abstract: Toxicological investigation suggests that exposures to complex secondary organic aerosol (SOA) products can result in adverse health effects in biological systems. However, the mechanism of adverse health effects is not yet understood. One of the major restrictions in studies of health effects of SOA is a particle exposure technique. In this study, we applied an innovative soft targeting technology using magnetic nanoparticles (MNP) to deliver SOAs onto target biological systems under a magnetic field. The exploratory exposure technology using MNP was demonstrated for the SOAs created from the reaction of ozone with alpha-pinene in an indoor Teflon film chamber. SOA increased the release of the proinflammatory mediator interleukin-8 by respiratory epithelial cells. These results support that MNP can effectively deliver SOAs to epithelial cells in vitro resulting in a significant biological effects.
authors.affiliation: Department of Environmental Sciences and Engineering, CB# 7431, Rosenau Hall, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. mjang@email.unc.edu
authors.forename: Myoseon
authors.initials: M
authors.lastname: Jang
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Ghio
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
mesh_terms: D000336:Aerosols; D000393:Air Pollutants / Q000737:chemistry / Q000633:toxicity*; D000081008:Bicyclic Monoterpenes; D002460:Cell Line; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D008962:Models, Theoretical; D039821:Monoterpenes / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry / Q000633:toxicity*; D010126:Ozone / Q000737:chemistry; D013329:Structure-Activity Relationship; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D000336:Aerosols; D000393:Air Pollutants; D000081008:Bicyclic Monoterpenes; D016209:Interleukin-8; D039821:Monoterpenes; D009930:Organic Chemicals; D010126:Ozone; C005451:alpha-pinene