A dual lanthanide probe suitable for optical (Tb3+ luminescence) and magnetic resonance imaging (Gd3+ relaxometry).
A new polyaminocarboxylate ligand derived from N,C-pyrazolylpyridine was synthesized. The luminescence and relaxometry properties of its Tb(3+) and Gd(3+) chelates were investigated in aqueous solutions. The Tb(3+) chelate is strongly luminescent having remarkable lifetime and quantum yield (tau=1.82ms and Phi=0.42). The 1/T(1) proton relaxivity at 20MHz and 25 degrees C (5.3s(-1)mM(-1)) of the Gd(3+) chelate was found to be comparable to that of the clinically used Gd-DTPA.
Picard
Claude
C
Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, CNRS UMR 5068, Université Paul Sabatier, 31062 Toulouse cedex 04, France. picard@chimie.ups-tlse.fr
Geum
Neri
N
Nasso
Isabelle
I
Mestre
Béatrice
B
Tisnès
Pierre
P
Laurent
Sophie
S
Muller
Robert N
RN
Elst
Luce Vander
LV
D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D008024:Ligands; D049449:Luminescence; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D011789:Quantum Theory; D012680:Sensitivity and Specificity; D012996:Solutions / Q000737:chemistry; D013725:Terbium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D002614:Chelating Agents; D008024:Ligands; D011720:Pyrazoles; D011725:Pyridines; D012996:Solutions; D014867:Water; D013725:Terbium; D005682:Gadolinium