title: Hepatosplenic gammadelta T-cell lymphoma with ring chromosome 7, an isochromosome 7q equivalent clonal chromosomal aberration.
abstract: Hepatosplenic T-cell lymphoma is a rare, clinically aggressive lymphoma. Most cases represent a neoplasm of mature non-activated gammadelta T cells. Isochromosome 7q i(7)(q10) is thought to be the primary cytogenetic abnormality of this disease. In this paper, we describe a hepatosplenic gammadelta T-cell lymphoma case, with clonal ring chromosome 7 exemplifying an isochromosome 7q equivalent clonal aberration. A 62-year-old female patient presented with thrombocytopenia, isolated hepatosplenomegaly, and extremely high levels of LDH. Bone marrow work-up demonstrated a sinusoidal cytotoxic T-cell infiltrate with blastic features, while molecular studies verified monoclonal rearrangement for both TCR gamma and TCR delta genes. Cytogenetics revealed clonal abnormalities including ring chromosome 7, trisomy 8, and der(19), while FISH analysis detected 7q amplification with partial deletion of 7p in ring chromosome 7. To the best of our knowledge, this is the first reported T-cell lymphoma case with ring chromosome 7.
authors.affiliation: Institute of Hematology and Immunology, National Medical Center, Budapest, Hungary.
authors.forename: Julia
authors.initials: J
authors.lastname: Tamaska
authors.forename: Emma
authors.initials: E
authors.lastname: Adam
authors.forename: Andras
authors.initials: A
authors.lastname: Kozma
authors.forename: Laszlo
authors.initials: L
authors.lastname: Gopcsa
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Andrikovics
authors.forename: Attila
authors.initials: A
authors.lastname: Tordai
authors.forename: Gabriella
authors.initials: G
authors.lastname: Halm
authors.forename: Laszlo
authors.initials: L
authors.lastname: Bereczki
authors.forename: Eniko
authors.initials: E
authors.lastname: Bagdi
authors.forename: Laszlo
authors.initials: L
authors.lastname: Krenacs
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000737:chemistry / Q000473:pathology; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D008113:Liver Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D032681:Spectral Karyotyping; D013160:Splenic Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm