title: Symptomatic relapse of neurologic syphilis after benzathine penicillin G therapy for primary or secondary syphilis in HIV-infected patients.
abstract: We describe 3 symptomatic cases of neurologic syphilis that occurred after the administration of the usual therapy for primary or secondary syphilis in human immunodeficiency virus (HIV)-infected patients. We discuss the difficulty of diagnosing neurosyphilis, the need for lumbar puncture, and risk factors of relapse. Because HIV infection may alter the natural history and response of neurologic syphilis to treatment, scrupulous follow-up and repeated cycles of therapy are warranted.
authors.affiliation: Department of Hepatogastroenterology, Hospices Civils de Lyon, Hôtel-Dieu Hospital, Lyon,France.
authors.forename: T
authors.initials: T
authors.lastname: Walter
authors.forename: B
authors.initials: B
authors.lastname: Lebouche
authors.forename: P
authors.initials: P
authors.lastname: Miailhes
authors.forename: L
authors.initials: L
authors.lastname: Cotte
authors.forename: C
authors.initials: C
authors.lastname: Roure
authors.forename: I
authors.initials: I
authors.lastname: Schlienger
authors.forename: C
authors.initials: C
authors.lastname: Trepo
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use; D015331:Cohort Studies; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010401:Penicillin G Benzathine / Q000627:therapeutic use*; D012008:Recurrence; D013587:Syphilis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D010401:Penicillin G Benzathine