title: Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum.
abstract: Shen-Min is a herbal product sold as a supplement for women to enhance hair growth. It is widely available across Asia, Europe, and the United States and sold without prescription as a hair nutritional supplement. We describe a case of acute liver injury in a 28-year-old white woman who developed symptomatic hepatitis 8 weeks after starting Shen-Min. All other potential causes of acute hepatitis including viral, hypoxic/ischemic, metabolic, and autoimmune etiologies were excluded. The liver injury slowly resolved over 3 weeks after discontinuing the herbal product. Although the mechanism of Shen-Min hepatotoxicity is unknown, we suspect an idiosyncratic reaction because the patient developed a fine maculopapular rash, mild eosinophilia, and did not overdose. Shen-Min is a Chinese herbal product with a mixture of several plants and vitamins including Polygonum multiflorum, a root that has been previously associated with hepatotoxicity. Nonetheless to our knowledge this is the first reported case of herbal-induced hepatotoxicity in a patient taking Shen-Min per se. Clinicians taking care of patients with acute hepatitis of unclear etiology should be aware that the consumption of Shen-Min, a hair supplement widely available in the United States and Western countries might cause acute hepatitis.
authors.affiliation: Division of Gastroenterology and Hepatology, Hospital Pablo Tobón Uribe and Gastro-Hepatology Group, University of Antioquia, Medellín, Colombia. acv69@hotmail.com
authors.forename: Andrés
authors.initials: A
authors.lastname: Cárdenas
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Restrepo
authors.forename: Fernando
authors.initials: F
authors.lastname: Sierra
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Correa
mesh_terms: D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006203:Hair Preparations / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D019934:International Normalized Ratio; D008099:Liver / Q000187:drug effects; D028502:Polygonum / Q000009:adverse effects*
chemical_list: D004365:Drugs, Chinese Herbal; D006203:Hair Preparations