title: Systems biology as a foundation for genome-scale synthetic biology.
abstract: As the ambitions of synthetic biology approach genome-scale engineering, comprehensive characterization of cellular systems is required, as well as a means to accurately model cell-scale molecular interactions. These requirements are coincident with the goals of systems biology and, thus, systems biology will become the foundation for genome-scale synthetic biology. Systems biology will form this foundation through its efforts to reconstruct and integrate cellular systems, develop the mathematics, theory and software tools for the accurate modeling of these integrated systems, and through evolutionary mechanisms. As genome-scale synthetic biology is so enabled, it will prove to be a positive feedback driver of systems biology by exposing and forcing researchers to confront those aspects of systems biology which are inadequately understood.
authors.affiliation: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
authors.forename: Christian L
authors.initials: CL
authors.lastname: Barrett
authors.forename: Tae Yong
authors.initials: TY
authors.lastname: Kim
authors.forename: Hyun Uk
authors.initials: HU
authors.lastname: Kim
authors.forename: Bernhard Ø
authors.initials: BØ
authors.lastname: Palsson
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Lee
mesh_terms: D001695:Biology / Q000379:methods*; D019295:Computational Biology / Q000379:methods; D019143:Evolution, Molecular; D016678:Genome / Q000235:genetics*; D008954:Models, Biological; D012984:Software; D049490:Systems Biology / Q000379:methods*