The role of cytokines in pharmacological modulation of hepatic ischemia/reperfusion injury.
Hepatic ischemia/reperfusion injury is a complication of liver resection surgery, transplantation and hypovolemic shock, leading to local and remote cellular damage and organ dysfunction. This injury is largely a result of an acute inflammatory response characterized by the induction of a cascade of proinflammatory mediators that culminates in the recruitment of leukocytes to the post-ischemic tissue leading to parenchymal cell injury. Endogenous regulatory mechanisms exist to attempt to control this inflammatory response. These include anti-inflammatory cytokines that function to suppress proinflammatory mediator expression. In this review, we address the current knowledge of the pro- and anti-inflammatory cytokine components of the acute liver inflammatory response to ischemia/reperfusion as well as how these cytokines can be manipulated to reduce post-ischemic liver injury.
Husted
Thomas L
TL
The Laboratory of Trauma, Sepsis & Inflammation Research, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0558, USA.
Lentsch
Alex B
AB
D000818:Animals; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism
D016207:Cytokines