title: Simple purification of recovered [18O]H2O by UV, ozone, and solid-phase extraction methods.
abstract: We have developed three methods for removing organic impurities as well as a solid-phase extraction (SPE) method for removing metallic and ionic impurities from recovered [18O]H2O. Preliminary experiments with [16O]H2O were used to determine the optimal purification conditions. These showed that UV irradiation rapidly (<4 h) eliminated low boiling point impurities such as acetonitrile and acetone with only a slight loss of mass. A combination of UV irradiation and purging with ozone removed high boiling point impurities such as ethanol and methanol more quickly than UV irradiation alone. UV irradiation followed by a SPE with [18O]H2O removed all organic and inorganic impurities. The purified [18O]H2O gave a saturation yield of 128.62+/-15.6 mCi/microA for [18F]fluoride and a 49.8+/-12.7% radiochemical yield for [18F]fluorodeoxyglucose.
authors.affiliation: Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea.
authors.forename: Woo Yeon
authors.initials: WY
authors.lastname: Moon
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Oh
authors.forename: Jun Hong
authors.initials: JH
authors.lastname: Cheon
authors.forename: Won Seok
authors.initials: WS
authors.lastname: Chae
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Lim
authors.forename: Si Man
authors.initials: SM
authors.lastname: Cho
authors.forename: Dae Hyuk
authors.initials: DH
authors.lastname: Moon