Species variability in cardiovascular research: the example of adrenocorticotrophin-induced hypertension.
1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.
Whitworth
Judith A
JA
The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia. director@jcsmr.anu.edu.au
Zhang
Yi
Y
Mangos
George
G
Kelly
John J
JJ
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena; D004285:Dogs; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000209:etiology*; D051379:Mice; D023421:Models, Animal; D009569:Nitric Oxide / Q000502:physiology; D051381:Rats; D012107:Research Design; D012756:Sheep; D013045:Species Specificity
D012739:Gonadal Steroid Hormones; D009569:Nitric Oxide; D000324:Adrenocorticotropic Hormone