Linoleic and oleic acids alter the licking responses to sweet, salt, sour, and bitter tastants in rats.
The free fatty acids (FFAs), linoleic and oleic acids, commonly found in dietary fats can be detected by rats on the basis of gustatory cues following conditioned taste aversion pairings. FFAs depolarize the membrane potential of isolated rat taste receptor cells by inhibiting delayed rectifying potassium channels. This study examined the licking response of rats to sweet, salt, sour, and bitter taste solutions when 88 muM linoleic acid, 88 muM oleic acid, or an 88 muM linoleic-oleic acid mixture was added to the solutions. The presence of linoleic, oleic, and the linoleic-oleic acid mixture in sweet solutions produced increases in the licking responses, whereas adding linoleic, oleic, and the linoleic-oleic acid mixture to salt, sour, or bitter taste solutions produced decreases in licking responses when compared with the licking responses to the solutions in the absence of the FFAs. We conclude that FFAs may act in the oral cavity to depolarize taste receptor cells and therefore to increase the perceived intensity of concomitant tastants, thus contributing to the enhanced palatability associated with foods containing high dietary fat.
Pittman
David W
DW
Department of Psychology, Wofford College, 429 North Church Street, Spartanburg, SC 29303, USA. pittmandw@wofford.edu
Labban
Caroline E
CE
Anderson
Abigail A
AA
O'Connor
Hayley E
HE
D000818:Animals; D004327:Drinking Behavior / Q000187:drug effects*; D019787:Linoleic Acid / Q000494:pharmacology*; D008297:Male; D019301:Oleic Acid / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013268:Stimulation, Chemical; D013649:Taste / Q000187:drug effects* / Q000502:physiology*; D013652:Taste Threshold / Q000187:drug effects
D019301:Oleic Acid; D019787:Linoleic Acid