Bisoxazolidine-catalyzed enantioselective alkynylation of aldehydes.
A C2-symmetric bisoxazolidine derived from aminoindanol has been successfully applied in the asymmetric alkynylation of aldehydes. The ligand is readily available, has a wide substrate scope, and catalyzes the formation of chiral propargylic alcohols with excellent yields and enantioselectivties.
Wolf
Christian
C
Department of Chemistry, Georgetown University, Washington, D.C. 20057, USA. cw27@georgetown.edu
Liu
Shuanglong
S