title: In vitro activity of tigecycline against multiple-drug-resistant, including pan-resistant, gram-negative and gram-positive clinical isolates from Greek hospitals.
abstract: The in vitro activities of tigecycline and selected antimicrobials were evaluated against a variety of multiple-drug-resistant clinical isolates, including extended-spectrum beta-lactamase- and/or metallo-beta-lactamase-producing gram-negative strains, colistin-resistant strains, vancomycin- and/or linezolid-resistant enterococci, and methicillin-resistant Staphylococcus aureus (MRSA). Tigecycline showed excellent activity against a collection of difficult-to-treat pathogens currently encountered in the hospital setting.
authors.affiliation: Fourth Department of Internal Medicine, Athens University School of Medicine, University General Hospital Attikon, 124 62 Chaidari, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Souli
authors.forename: Flora V
authors.initials: FV
authors.lastname: Kontopidou
authors.forename: Evangelos
authors.initials: E
authors.lastname: Koratzanis
authors.forename: Anastasia
authors.initials: A
authors.lastname: Antoniadou
authors.forename: Efthimia
authors.initials: E
authors.lastname: Giannitsioti
authors.forename: Pinelopi
authors.initials: P
authors.lastname: Evangelopoulou
authors.forename: Sofia
authors.initials: S
authors.lastname: Kannavaki
authors.forename: Helen
authors.initials: H
authors.lastname: Giamarellou
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006115:Greece; D006801:Humans; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline