title: Synthesis of mono- and symmetrical di-N-hydroxy- and N-aminoguanidines.
abstract: Novel mono- and symmetrical di-N-hydroxy- and N-aminoguanidines were readily prepared from the reaction of diverse hydroxylamines or hydrazines with reagent classes di(benzotriazol-1-yl)methanimine 6, (bis-benzotriazol-1-yl-methylene)amines 8a,b, benzotriazole-1-carboxamidines 10a-i, benzotriazole-1-carboximidamides 11a,b, and N'-hydroxy-1H-1,2,3-benzotriazole-1-carboximidamide 18. The preparation is described for a variety of N-hydroxy- and N-aminoguanidines with different substitution patterns in good yields.
authors.affiliation: Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Niveen M
authors.initials: NM
authors.lastname: Khashab
authors.forename: Sergey
authors.initials: S
authors.lastname: Bobrov
authors.forename: Megumi
authors.initials: M
authors.lastname: Yoshioka
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D006146:Guanidines / Q000138:chemical synthesis / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry; D019811:Hydroxylamine / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry
chemical_list: D006146:Guanidines; D006834:Hydrazines; D014230:Triazoles; C029424:hydrazine; D019811:Hydroxylamine; C062817:N-hydroxy-N'-aminoguanidine; C012771:benzotriazole; C004479:pimagedine