The emerging role of the histamine H4 receptor in anti-inflammatory therapy.
Antagonists for the Histamine H(1) receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H(4) receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H(4) receptor as a drug target.
Lim
Herman D
HD
Division of Medicinal Chemistry, Faculty of Sciences, Leiden/Amsterdam Center of Drug Research, LACDR, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.
Smits
Rogier A
RA
Leurs
Rob
R
De Esch
Iwan J P
IJ
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D008024:Ligands; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000276:immunology; D011968:Receptors, Histamine / Q000235:genetics / Q000276:immunology; D000074040:Receptors, Histamine H4; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; C418607:HRH4 protein, human; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4