Cutaneous intravascular NK-cell lymphoma: report of a rare variant associated with Epstein-Barr virus.
Intravascular lymphoma (IVL) is a rare variant of non-Hodgkin lymphoma with a predilection for skin and brain. Except a few cases of T-cell lineage, most of the reported cases were large B-cell lymphomas. We encountered a case of cutaneous IVL in a 71-year-old woman presenting with multiple erythematous patches and nodules on her trunk and extremities. The intravascular large cells showed an immunophenotype of CD3epsilon(+);, CD5(-), CD20(-), CD30(-), CD56(+), and TIA-1(+). The lymphoma cells were also positive for Epstein-Barr virus by Epstein-Barr virus-encoded RNA in situ hybridization test and the T-cell receptor gene was germline. This IVL differs from nasal type NK/T-cell lymphoma only by its intravascular nature. Only 3 cases of intravascular NK-cell lymphoma have been reported before. Because this variant is extremely rare, our case is documented and compared with the 3 previously reported cases.
Kuo
Tseng-tong
TT
Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kwei San, Taoyuan, Taiwan. ttkuo@adm.cgmh.org.tw
Chen
Ming-Jing
MJ
Kuo
Ming-Chung
MC
D000368:Aged; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D012878:Skin Neoplasms / Q000821:virology*; D019043:Vascular Neoplasms / Q000821:virology*
D012367:RNA, Viral