title: Systemic allergic reactions to aprotinin injection around the Achilles tendon.
abstract: Local aprotinin injections are used in the treatment of chronic tendinopathy. Severe allergic reactions, although uncommon, have been reported. We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.
authors.affiliation: Department of Trauma and Orthopaedic Surgery, Keele University School of Medicine, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire, England.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Rukin
authors.forename: Nicola
authors.initials: N
authors.lastname: Maffulli
mesh_terms: D000125:Achilles Tendon / Q000293:injuries*; D007611:Aprotinin / Q000009:adverse effects* / Q000276:immunology; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008875:Middle Aged; D052256:Tendinopathy / Q000188:drug therapy; D014361:Trypsin Inhibitors / Q000009:adverse effects* / Q000276:immunology
chemical_list: D014361:Trypsin Inhibitors; D007611:Aprotinin