[The role of anti-lactoferrin activity of bacteria in their persistence].
The role of anti-lactoferrin activity (ALfA) of bacteria in the persistence phenomenon, i.e. long survival of a causative agent in a host body, was studied in experimental staphylococcal infection. In experimental animals infected with isogenic clones of Staphylococcus aureus with different level of ALfA, longer terms were noted in bacterial recovery of staphylococci with this ability. Analysis on the occurrence and level of ALfA in clinical isolates of bacteria, isolated from different forms of infectious process, confirmed the significance of this sign in the persistence of a causative agent. High values of penetrance and expression of ALfA in bacteria were revealed in strains of microorganisms, isolated from chronic inflammatory diseases and from bacterial carriers.
Valyshev
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Valysheva
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D000818:Animals; D001685:Biological Factors / Q000378:metabolism*; D002353:Carrier State / Q000382:microbiology; D002908:Chronic Disease; D006801:Humans; D007781:Lactoferrin / Q000037:antagonists & inhibitors* / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000254:growth & development / Q000378:metabolism*
D001685:Biological Factors; D007781:Lactoferrin