title: Autoimmune neutropenia of infancy with multiple brain abscesses during the course of human herpesvirus-6 infection.
abstract: Autoimmune neutropenia of infancy is characterized by recurrent infections such as pneumonia, otitis media, impetigo, purulent skin regions, gastritis, and upper respiratory infection. However, severe bacterial infection is uncommon. This report documents a 9-month-old boy presenting with autoimmune neutropenia in association with multiple brain abscesses during the course of human herpesvirus (HHV)-6 infection. HHV-6 has a tendency of neurovirulence, which can destroy the blood-brain barrier and facilitate the easy invasion of agents inside the brain. Although autoimmune neutropenia of infancy is benign and self limiting, it must be emphasized that severe bacterial infection will be induced by concurrent viral infection in this specific disorder.
authors.affiliation: Department of Pediatrics, Saga University, Saga, Japan. tokushm@post.saga-med.ac.jp
authors.forename: Miyoko
authors.initials: M
authors.lastname: Tokushima-Imayoshi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Onoue
authors.forename: Muneaki
authors.initials: M
authors.lastname: Matsuo
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yoshida
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.forename: Masao
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Hamasaki
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishii
mesh_terms: D001327:Autoimmune Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D001424:Bacterial Infections / Q000150:complications; D001922:Brain Abscess / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D015654:Herpesvirus 6, Human; D006801:Humans; D007223:Infant; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D019349:Roseolovirus Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy