title: [Effect of long-term intake of Y3+ in drinking water on immune function of rats].
abstract: OBJECTIVE
  The aim of this paper was to learn the effects of Y3+ on immune function of rats.
  
  
  METHODS
  The rats were fed with water dissolved different level Y3+ (0 mg/L, 0.534 mg/L, 53.4 mg/L, 5340 mg/L) for 6 months. The relative weight of spleen and thymus of F1 rat were calculated, and the functions of cellular immunity and humoral immunity were determined by flow cytometry (FCM) and enzyme-linked immunosorbnent assay (ELISA), respectively.
  
  
  RESULTS
  The results showed that a significant increase of IgG, IgM were observed in the dosage group of 0.534 mg/L, in 53.4 mg/L, no change was observed. In contrast, a significantly decrease in CD3, CD8, , IgG, IgM and increase in CD4/CD8 were observed in 5340 mg/L group.
  
  
  CONCLUSIONS
  Long-term intake of Y3+ in low level had certain impact on cellular immunity and humoral immunity of rats' offspring.
authors.affiliation: Department of Biotechnology, Jinan University, Guangzhou 510632, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Yang
authors.forename: Jie-Sheng
authors.initials: JS
authors.lastname: Liu
authors.forename: Xin-Lian
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D005260:Female; D007107:Immune System / Q000187:drug effects*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D018812:Paternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016176:T-Lymphocyte Subsets / Q000187:drug effects; D013997:Time Factors; D015019:Yttrium / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015019:Yttrium