Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr.
Five tetranortriterpenoids, domesticulide A-E (1-5), were isolated from seeds of Lansium domesticum Corr. together with 11 known triterpenoids (6-16). Their structures were elucidated by analysis of their spectroscopic data. Compounds 2, 3, 4, 7, 8, 10, 11, and 15 showed antimalarial activity against Plasmodium falciparum with IC(50)'s of 2.4-9.7 microg/ml.
Saewan
Nisakorn
N
School of Science, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand. nisakorn@mfu.ac.th
Sutherland
John D
JD
Chantrapromma
Kan
K
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D012639:Seeds / Q000737:chemistry*
D000962:Antimalarials; D036701:Limonins; D010936:Plant Extracts