Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia.
BACKGROUND
Paraoxonase (PON) 1 is a high-density lipoprotein-associated enzyme that may protect against cardiovascular disease.


METHODS
We have studied the contribution of PON-1 and PON-2 single nucleotide polymorphisms (SNP; L55M, Q192R and T-107C, S311C) to the intima-media thickness of the common carotid artery in a population of children with classic familial hypercholesterolaemia.


RESULTS
The L-variant of the L55M SNP was associated with increased common carotid artery intima-media thickness when compared with the M-variant (P value for trend 0.03). No significant relationship was observed between the other SNP and common carotid artery intima-media thickness.


CONCLUSIONS
Our findings suggest that variation at the PON-1 locus contributes to early atherosclerosis in children with familial hypercholesterolaemia.
Roest
Mark
M
Research Laboratory of the Department of Clinical Chemistry, University Medical Center, Utrecht, The Netherlands. m.roest@azu.nl
Rodenburg
Jessica
J
Wiegman
Albert
A
Kastelein
John J P
JJ
Voorbij
Hieronymus A M
HA
D000293:Adolescent; D043303:Aryldialkylphosphatase / Q000235:genetics*; D050197:Atherosclerosis / Q000235:genetics* / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology*; D002648:Child; D005838:Genotype; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D017539:Tunica Intima / Q000473:pathology
D043303:Aryldialkylphosphatase