title: One ring to rule them all? Another cellular responsibility for PCNA.
abstract: To prevent duplication or loss of genomic regions during DNA replication, it is essential that the entire genome is copied precisely once every S phase. Cells achieve this by mutually exclusive regulation of origin firing and licensing. A crucial protein that is involved in origin licensing is chromatin licensing and DNA replication factor 1 (CDT1) and, therefore, activity of this protein must be strictly controlled. Four recent articles have demonstrated that proliferating cell nuclear antigen (PCNA), an essential sliding clamp used in replication and DNA repair, has a crucial role in this process by mediating the proteasomal degradation of CDT1.
authors.affiliation: Genome Damage and Stability Centre, University of Sussex, Brighton, BN19RQ, UK. c.m.green@sussex.ac.uk
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Green
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology*; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D018809:Proliferating Cell Nuclear Antigen / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D029867:Xenopus Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: C406819:Cdt1 protein, Xenopus; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D018809:Proliferating Cell Nuclear Antigen; D029867:Xenopus Proteins; D046988:Proteasome Endopeptidase Complex