title: Herpes simplex virus type 1 shows multiple interactions with sulfonated compounds at binding, penetration, and cell-to-cell passage.
abstract: Herpes simplex virus type 1 (HSV-1) uses multicomponent mechanisms for binding, penetration, and cell-to-cell passage. These processes are affected by polysulfonated compounds. In this paper we have addressed the question of whether the same or different interactions of HSV-1 with polysulfonated compounds are involved in binding, penetration, and passage. For this, we have compared the inhibitory dose-response for a series of polysulfonated and cationic compounds known to block HSV-1 infections. These comparisons were done at the level of binding, penetration, and cell-to-cell passage. Variations in the parameters of the dose-response curves - IC(50) and Hill coefficients (n (H)) - are consistent with HSV-1 having multiple interactions with sulfonated cellular components in all these processes. Some of the interactions seem to be common to the three processes, while others are particular for each one.
authors.affiliation: Department of Molecular Biology and Biochemistry, Center for Virus Research, University of California, Irvine, CA 92697, USA. jsaguila@uci.edu
authors.forename: José Santiago
authors.initials: JS
authors.lastname: Aguilar
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Held
authors.forename: Edward K
authors.initials: EK
authors.lastname: Wagner
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D004338:Drug Combinations; D004347:Drug Interactions; D018259:Herpesvirus 1, Human / Q000378:metabolism*; D011817:Rabbits; D013452:Sulfonium Compounds / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D014709:Vero Cells; D053585:Virus Attachment / Q000187:drug effects*; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D004338:Drug Combinations; D013452:Sulfonium Compounds