title: Comparing antibody and small-molecule therapies for cancer.
abstract: The 'magic bullet' concept of specifically targeting cancer cells at the same time as sparing normal tissues is now proven, as several monoclonal antibodies and targeted small-molecule compounds have been approved for cancer treatment. Both antibodies and small-molecule compounds are therefore promising tools for target-protein-based cancer therapy. We discuss and compare the distinctive properties of these two therapeutic strategies so as to provide a better view for the development of new drugs and the future direction of cancer therapy.
authors.affiliation: Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo, 060-8556, Japan. imai@sapmed.ac.jp
authors.forename: Kohzoh
authors.initials: K
authors.lastname: Imai
authors.forename: Akinori
authors.initials: A
authors.lastname: Takaoka
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D015507:Drugs, Investigational