title: Oropharyngeal surgery for obstructive sleep apnoea in CPAP failures.
abstract: Continuous positive airway pressure (CPAP) for moderate and severe obstructive sleep apnoea (OSA), albeit effective management, is poorly tolerated. This study looks at the role of laser assisted uvulopalatoplasty (LAUP) in patients with moderate and severe OSA who would not tolerate CPAP. All subjects underwent dynamic sleep nasendoscopy to determine the anatomical level of obstruction and their suitability for the procedure. Twenty subjects were included. Pre-procedure mean apnoea-hypopnea index (AHI) was 47.9 per hour (21.3-101) and mean Epworth sleepiness score 15.6 (4-23). Post operative polysomnography at >or=4 months showed a 73% reduction in AHI to a mean of 12.9 per hour. Two subjects still required CPAP post procedure but both at reduced pressure. Epworth sleepiness questionnaire scores were reduced by a mean of 7.9 points. There was no confounding weight loss. The finding that LAUP offers an effective instrument to reduce the severity of OSA in patients intolerant of CPAP results disagree with the conclusion of the recent Cochrane Collabration review of surgery for OSA. We believe this is due to the careful selection of patients for LAUP based on the anatomical level of obstruction as opposed to random selection.
authors.affiliation: Royal National Throat Nose and Ear Hospital, 330/332 Grays Inn Road, London, WC1X 8DA, UK.
authors.forename: Edward
authors.initials: E
authors.lastname: Chisholm
authors.forename: Bhik
authors.initials: B
authors.lastname: Kotecha
mesh_terms: D000328:Adult; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009960:Oropharynx / Q000601:surgery*; D020181:Sleep Apnea, Obstructive / Q000601:surgery* / Q000628:therapy; D011795:Surveys and Questionnaires; D017211:Treatment Failure