title: A preliminary report on a novel electrospray technique for nanoparticle based biomedical implants coating: precision electrospraying.
abstract: The compatibility and biological efficacy of biomedical implants can be enhanced by coating their surface with appropriate agents. For predictable functioning of implants in situ, it is often desirable to obtain an extremely uniform coating thickness without effects on component dimensions or functions. Conventional coating techniques require rigorous processing conditions and often have limited adhesion and composition properties. In the present study, the authors report a novel precision electrospraying technique that allows both degradable and nondegradable coatings to be placed. Thin metallic slabs, springs, and biodegradable sintered microsphere scaffolds were coated with poly(lactide-co-glycolide) (PLAGA) using this technique. The effects of process parameters such as coating material concentration and applied voltage were studied using PLAGA and poly(ethylene glycol) coatings. Morphologies of coated surfaces were qualitatively characterized by scanning electron microscopy. Qualitative observations suggested that the coatings were composed of particles of various size/shape and agglomerates with different porous architectures. PLAGA coatings of uniform thickness were observed on all surfaces. Spherical nanoparticle poly(ethylene glycol) coatings (462-930 nm) were observed at all concentrations studied. This study found that the precision electrospraying technique is elegant, rapid, and reproducible with precise control over coating thickness (mum to mm) and is a useful alternative method for surface modification of biomedical implants.
authors.affiliation: Department of Orthopaedic Surgery, University of Virginia, Virginia 22903, USA.
authors.forename: Sangamesh G
authors.initials: SG
authors.lastname: Kumbar
authors.forename: Subhabrata
authors.initials: S
authors.lastname: Bhattacharyya
authors.forename: Swaminathan
authors.initials: S
authors.lastname: Sethuraman
authors.forename: Cato T
authors.initials: CT
authors.lastname: Laurencin
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D011098:Polyglactin 910 / Q000737:chemistry*; D019736:Prostheses and Implants / Q000648:ultrastructure
chemical_list: D020099:Coated Materials, Biocompatible; D011098:Polyglactin 910