[Initial studies of microemulsion formulation for the delivery of a combination of Tanshiones and Salvianolic acids].
OBJECTIVE
To study influential factor on the microemulsion formulation for the delivery of a combination of Tanshiones and Salvianlic acids.


METHODS
Area of oil-in-water microemulsion was investigated through pseudo-ternary phase diagrams that evalued the influence of different oliphase, Km-value and waterphase. Viscosity of microemulsions was measured to investigate the influence of oliphase and waterphase carrying different dose drugs respectively. Polydispersity index, intensity mean, volum mean and number mean of microemulsion particles were detected to value the particles diameter and their disposition.


RESULTS
Different oliphase, K.-value and waterphase had noticeable influence on the area of microemulsions and formulation composed of ethyl oleate, Solutrol HS15-EtOH (8 : 2), and the solution of Salvianolic acids, was the best one Viscosity of microemulsions was slightly influenced by oliphase and waterphase carrying different dose drugs respectively, but significantly influenced by the ratio of waterphase. The particles diameter and their disposition were also influenced by the ratio of waterphase. When the ratio of waterphase was not less than 87.5%, the particles were well-distributed and very stable.


CONCLUSIONS
The formulation is composed of ethyl oleate, Solutrol HS15-EtOH (8 : 2), and water can be used to delive the combination of Tanshiones and Salvianolic acids.
Li
Hong-Lei
HL
Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. lih1003@163.com
Zhang
Zhong-Yi
ZY
Cheng
Hai-Min
HM
D045784:Abietanes; D002109:Caffeic Acids / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry; D009829:Oleic Acids; D010316:Particle Size; D010616:Phenanthrenes / Q000008:administration & dosage*; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D012997:Solvents; D013678:Technology, Pharmaceutical / Q000379:methods*; D014783:Viscosity; D014867:Water
D045784:Abietanes; D002109:Caffeic Acids; D004337:Drug Carriers; D004655:Emulsions; D009829:Oleic Acids; D010616:Phenanthrenes; D012997:Solvents; C021751:tanshinone; D014867:Water; C033180:ethyl oleate