title: Comparative study of salivary pH and volume in adults with chronic laryngopharyngitis by gastroesophageal reflux disease before and after treatment.
abstract: BACKGROUND
  Gastroesophageal Reflux Disease (GERD) is the most prevalent digestive disease of the modern society and has been associated with abnormalities in the larynx and pharynx (LPR). Nonetheless, little is known about the mechanisms involved in this atypical form of the disease. Contradictory clinical data suggest a defense deficit at this segment. Saliva with its organic and inorganic components is responsible for the homeostasis of the oral mucosa and the digestive tract. Salivary pH and volume abnormalities have been linked to laryngopharyngeal symptoms of GERD and LPR. In a recent study we demonstrated significant salivary pH reduction in patients with LPR. Another study found correlation between reduced salivary pH and volume directly related to esophageal pH-metry results.
  
  
  OBJECTIVE
  To evaluate salivary pH and volume before and after clinical treatment of LPR.
  
  
  METHODS
  Twenty-three adults with LPR had total fasting saliva tested before and after a 12-week course of oral proton pump inhibitor.
  
  
  RESULTS
  A statistically significant difference was found in salivary pH before and after treatment with increase of pH values after control of the disease (p<0.001). Salivary volumes of treated patients were also significantly higher than in pre-treated patients (p=0.009).
  
  
  CONCLUSIONS
  These findings suggest that salivary pH and volume are influenced by the presence of gastroesophageal contents and that salivary pH monitoring can potentially become a cost-effective method for diagnosing and controlling LPR.
authors.affiliation: School of Medical Sciences of the Santa Casa de SP, Brazil.
authors.forename: Claudia Alessandra
authors.initials: CA
authors.lastname: Eckley
authors.forename: Henrique Olival
authors.initials: HO
authors.lastname: Costa
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007827:Laryngitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009853:Omeprazole / Q000494:pharmacology / Q000627:therapeutic use*; D010612:Pharyngitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000494:pharmacology; D012463:Saliva / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism
chemical_list: D054328:Proton Pump Inhibitors; D017494:Proton Pumps; D009853:Omeprazole