A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines.
Novel cisplatin analogs dichloro[4,4'-bis(4,4,4-trifluorobutyl)-2,2'-bipyridine]platinum (1) and fac-tricarbonylchloro[4,4'-bis(4,4,4-trifluorobutyl)-2,2'-bipyridine]rhenium (3) were synthesized and evaluated for their cytotoxicity. While 3 was not cytotoxic, 1 was 14 to 125 times more lethal than cisplatin in breast, prostate, and lung cancer cell lines. Compound 1 was able to induce apoptosis and the presence of the platinum atom was essential to its function as a cytotoxin.
Elwell
Kyler E
KE
Chemistry Department, PO Box 454003, UNLV, Las Vegas, NV 89154-4003, USA.
Hall
Casey
C
Tharkar
Shweta
S
Giraud
Yvonne
Y
Bennett
Byron
B
Bae
Chulsung
C
Carper
Stephen W
SW
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D002945:Cisplatin / Q000494:pharmacology*; D005260:Female; D017611:Fluorine Compounds / Q000737:chemistry; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D017611:Fluorine Compounds; D011725:Pyridines; C023666:pyridine; D002945:Cisplatin