Phenolic constituents of the roots of Sophora flavescens.
From the roots of Sophora flavescens collected in Taiwan, four new prenylflavonoids, sophoraflavanone K (1), sophoraflavanone L (2), 8-lavandulylkaempferol (3), and cyclokuraridin (4), a new arylbenzofuran, 2-(2,4-dihydroxy-5-prenylphenyl)-5,6-methylenedioxybenzofuran (5), and a new prenyldibenzoyl derivative, sophoradione (6), were isolated. The structures of 1-6 were determined by spectroscopic data analysis. Compounds 2-6 were evaluated for cytotoxic activity against the KB epidermoid carcinoma cell line.
Shen
Chien-Chang
CC
National Research Institute of Chinese Medicine, No. 155-1, Sec. 2, Li Nung Street, Peitou, Taipei, Taiwan, Republic of China.
Lin
Ting-Wei
TW
Huang
Yu-Ling
YL
Wan
Shr-Ting
ST
Shien
Bor-Jinn
BJ
Chen
Chien-Chih
CC
D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029909:Sophora / Q000737:chemistry*; D013624:Taiwan
D010636:Phenols