Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain.
Insulin insufficiency has multiple actions on the CNS. Three weeks after streptozotocin-induced diabetes in rats, we found a preferential downregulation of l-[(3)H]glutamate-labeled NMDA receptors in primary sensory cortical regions. Layers I-III of the parietal cortex and superficial piriform cortex were the most sensitive followed by other cortical regions and, in turn, deeper brain structures. These effects on NMDA receptors can potentially explain some of the known CNS effects of diabetes.
Bean
LeDon
L
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Zheng
Hong
H
Patel
Kaushik P
KP
Monaghan
Daniel T
DT
D000818:Animals; D001667:Binding, Competitive / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism* / Q000503:physiopathology; D001928:Brain Diseases, Metabolic / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000378:metabolism / Q000503:physiopathology; D048909:Diabetes Complications / Q000378:metabolism* / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D007328:Insulin / Q000172:deficiency*; D008297:Male; D009474:Neurons / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D014316:Tritium
D007328:Insulin; D016194:Receptors, N-Methyl-D-Aspartate; D014316:Tritium; D018698:Glutamic Acid; D005947:Glucose