[Liver lesions in children with hepatitis B virus associated glomerulonephritis].
OBJECTIVE
To investigate the pathological changes of liver in children with hepatitis B virus associated glomerulonephritis (HBV-GN).


METHODS
Thirteen children with HBV-GN (aged from 2-14 years) underwent renal and liver biopsy. The biopsy findings were analyzed.


RESULTS
Different degrees of hepatic lesions were seen in all of the 13 patients, mild lesions accounting for 69.2% (9/13). HBSAg positive was the most common in the liver tissue [76.9% (10/13)]. Among the renal lesions, membranous glomerulopathy accounted for 69.2%( 9/13), followed by membranoproliferative glomerulonephritis 30.8% (4/13). HBsAg and HBcAg positive were presented in all patients' kidney tissues. HBV antigens were detected in stroma between nephric tubule in all samples. Four patients presented with HBcAg positive in both live and kidneys.


CONCLUSIONS
The children with HBV-GN couple with liver lesions. The severity of the renal lesions is not always accord with that of the liver lesions. The appearance of HBcAg in both kidneys and liver indicates severe lesions of the two organs. It is suggested that a liver-kidney holistic treatment is necessary for children with HBV-GN.
Dang
Xi-Qiang
XQ
Laboratory of Pediatric Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China. happydang@tom.com
Yi
Zhu-Wen
ZW
He
Xiao-Jie
XJ
Mo
Shuang-Hong
SH
Xu
Zi-Chuan
ZC
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D006509:Hepatitis B / Q000150:complications* / Q000473:pathology; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008297:Male
D006512:Hepatitis B Core Antigens