Squalamine lactate for exudative age-related macular degeneration.
Squalamine lactate inhibits angiogenesis by a long-lived, intracellular mechanism of action. The drug is taken up into activated endothelial cells through caveolae, small invaginations in the cellular membrane. Subsequently, the drug binds to and "chaperones" calmodulin to an intracellular membrane compartment and blocks angiogenesis at several levels. A series of basic investigations, preclinical studies, and human clinical trials have begun to establish the proof of concept, efficacy, and safety parameters for use of squalamine lactate as a therapeutic agent for exudative age-related macular degeneration and several types of malignancies.
Connolly
Brian
B
Retina Associates of Western New York, 890 Westfall Road, Suite D, Rochester, NY 14618, USA. drbpconn@yahoo.com
Desai
Avinash
A
Garcia
Charles A
CA
Thomas
Edgar
E
Gast
Michael J
MJ
D000818:Animals; D002777:Cholestanols / Q000627:therapeutic use*; D005122:Exudates and Transudates; D006801:Humans; D007773:Lactates / Q000627:therapeutic use*; D008268:Macular Degeneration / Q000188:drug therapy*; D016896:Treatment Outcome
D002777:Cholestanols; D007773:Lactates; C488568:squalamine lactate