[Study on the sense neuropeptides of nasal mucosa in the allergic rhinitis animal model].
OBJECTIVE
To explore the roles of the sense neuropeptides in allergic rhinitis by observing their changes in the nasal mucosa after cutting the nasal autonomic nervous.


METHODS
(1) Twelve rabbits were divided into two groups: group A (sensitized) and group B (control). Four rabbits were killed respectively in one and four weeks in group A after being sensitized . Two rabbits were killed respectively at the same time in group B. Their nasal mucosa were collected for detecting substance P (SP) and calcitonin gene-related peptide (CGRP) by immunohistochemistry. (2) Twenty-four rabbits were divided into two groups: group A (sphenopalatine nerve was cut), group B (sympathetic nerve was cut). Four rabbits were killed respectively in one, two, and four weeks in group A and B. Their nasal mucosa were collected for immunohistochemistry examination.


RESULTS
(1) SP and CGRP were apparently higher in allergic rabbits than non-allergic ones. (2) SP and CGRP decreased apparently in one and two weeks in group A and appeared no difference in four weeks. There were no apparently difference in group B among four weeks.


CONCLUSIONS
SP and CGRP are correlative with the occurring and developing of all allergic rhinitis.
Shi
Song
S
Department of Otolaryngology, Shanghai Changhai Hospital, Shanghai 200433, China. shisongwj@sina.com
Zhou
Shuimiao
S
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D004195:Disease Models, Animal; D009297:Nasal Mucosa / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D011817:Rabbits; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology; D013373:Substance P / Q000378:metabolism
D009479:Neuropeptides; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide