Protective effect of Ocimum sanctum L after high-dose 131iodine exposure in mice: an in vivo study.
Radioprotective effect of aqueous extract of Ocimum sanctum (40 mg/kg body weight, for 15 days) in mice exposed to high-doses (3.7 MBq) of oral 131iodine was investigated by studying the organ weights, lipid peroxidation and antioxidant defense enzymes in various target organs like liver, kidneys, salivary glands and stomach at 24 hr after exposure in adult Swiss mice. The mean weight of the salivary glands showed significant increase after 131iodine administration. 131iodine exposure significantly increased lipid peroxidation in kidneys and salivary glands in comparison to control animals. Pretreatment with O. sanctum in radioiodine exposed group showed significant reduction in lipid peroxidation in both kidneys and salivary glands. In liver, reduced glutathione (GSH) levels showed significant reduction after radioiodine exposure while pretreatment with O. sanctum exhibited less depletion in GSH level even after 131iodine exposure. However, no such changes were observed in stomach. The results indicate the possibility of using aqueous extract of O. sanctum for ameliorating 131Iodine induced damage to the salivary glands.
Bhartiya
Uma S
US
Laboratory Nuclear Medicine Section, Radiochemistry & Isotope Group, BARC, C/O Tata Memorial Hospital Annexe, Parel, Mumbai, India. umapat@yahoo.com
Raut
Yogita S
YS
Joseph
Lebana J
LJ
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D007457:Iodine Radioisotopes; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D031339:Ocimum / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012469:Salivary Glands / Q000187:drug effects / Q000528:radiation effects
D000975:Antioxidants; D007457:Iodine Radioisotopes; D010936:Plant Extracts; D011837:Radiation-Protective Agents