Nanocompatible chemistry toward fabrication of target-specific gold nanoparticles.
Nanocompatible chemistry which utilizes a novel nontoxic phosphino amino acid as a reducing agent has resulted in the development of therapeutically useful gold nanoparticles under biologically benign media. Stabilization of gold nanoparticles by the edible gum arabic matrix has provided an effective pathway toward in vivo stable target-specific gold nanoparticles.
Kannan
Raghuraman
R
Department of Radiology, University of Missouri-Columbia, Columbia, Missouri 65212, USA. kannanr@health.missouri.edu
Rahing
Valerie
V
Cutler
Cathy
C
Pandrapragada
Ravi
R
Katti
Kavita K
KK
Kattumuri
Vijaya
V
Robertson
J David
JD
Casteel
Stan J
SJ
Jurisson
Silvia
S
Smith
Charles
C
Boote
Evan
E
Katti
Kattesh V
KV
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000493:pharmacokinetics; D004355:Drug Stability; D006046:Gold / Q000737:chemistry* / Q000493:pharmacokinetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008815:Mice, Inbred Strains; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine; D010316:Particle Size; D013499:Surface Properties; D014018:Tissue Distribution
D001672:Biocompatible Materials; D006046:Gold