title: Micellization and drug solubilization in aqueous solutions of a diblock copolymer of ethylene oxide and phenyl glycidyl ether.
abstract: The aim of this study was to define a block copolymer micellar system with a high solubilization capacity for poorly soluble aromatic drugs. Ethylene oxide and phenyl glycidyl ether were sequentially polymerized to form the diblock copolymer G5E67 (G = phenyl glycidyl ether, OCH2CH(CH2OC6H5); E = oxyethylene, OCH2CH2; subscripts denote number-average block lengths in repeat units). The association properties in aqueous solution over the range 20-50 degrees C were investigated by surface tensiometry and light scattering, yielding values of the cmc, hydrodynamic radius, and association number; gel boundaries in concentrated micellar solution were investigated by tube inversion. The solubilization capacity of G5E67 for the poorly water-soluble drug griseofulvin was higher than that of a triblock EGE copolymer of longer G block length and considerably higher than that achieved with poloxamers (EmPnEm, P = oxypropylene).
authors.affiliation: Department of Physics of Condensed Matter, University of Santiago de Compostela, E-15706 Santiago de Compostela, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Taboada
authors.forename: Gemma
authors.initials: G
authors.lastname: Velasquez
authors.forename: Silvia
authors.initials: S
authors.lastname: Barbosa
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Yang
authors.forename: S Keith
authors.initials: SK
authors.lastname: Nixon
authors.forename: Zhengyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Frank
authors.initials: F
authors.lastname: Heatley
authors.forename: Marianne
authors.initials: M
authors.lastname: Ashford
authors.forename: Victor
authors.initials: V
authors.lastname: Mosquera
authors.forename: David
authors.initials: D
authors.lastname: Attwood
authors.forename: Colin
authors.initials: C
authors.lastname: Booth
mesh_terms: D005027:Ethylene Oxide / Q000737:chemistry*; D005782:Gels / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010647:Phenyl Ethers / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D005782:Gels; D008823:Micelles; D004364:Pharmaceutical Preparations; D010647:Phenyl Ethers; D011108:Polymers; D012996:Solutions; D014867:Water; C016050:phenylglycidyl ether; D005027:Ethylene Oxide