The plasma levels of soluble P-selectin in subjects with prediabetes.
Prediabetes has been associated with an increased risk of cardiovascular disease and mortality. Soluble P-selectin (sP-selectin) is an index of platelet activation and also a risk factor for future vascular events. sP-selectin levels were investigated in prediabetic subjects who had no confounding factors such as hypertension, obesity or dyslipidaemia. sP-selectin, hsCRP levels and HOMA-IR indexes were measured in 40 prediabetic subjects (n = 24 for IFG and n = 16 for IGT) and age-, sex- and BMI-matched 40 healthy controls. sP-selectin levels in prediabetic subjects were not significantly different compared with those in controls (p = 0.12). Prediabetic group had similar hsCRP (p = 0.29), higher HOMA-IR indexes (p < 0.001) and lower HDL cholesterol levels (p = 0.001) when compared with healthy controls. The power of the study was 0.93 for sP-selectin, 0.7 for hsCRP and 1.0 for HOMA. Our data suggest that sP-selectin may not contribute to the prothrombotic state as well as the accelerated atherogenesis associated with prediabetes.
Dogru
T
T
Department of Internal Medicine, Gulhance School of Medicine, Etlik, Ankara, Turkey. teomandogru@yahoo.com
Tasci
I
I
Sonmez
A
A
Genc
H
H
Gok
M
M
Yilmaz
M I
MI
Ural
A U
AU
Olgun
A
A
Kilic
S
S
Bozoglu
E
E
Erdem
G
G
Erbil
K
K
D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D011236:Prediabetic State / Q000097:blood*; D012307:Risk Factors
D019007:P-Selectin; D002097:C-Reactive Protein