title: Successful treatment of an endodermal sinus tumor of the vagina by chemotherapy alone: a rare case of an infant diagnosed by pathological examination of discharged tumor fragment.
abstract: A 7-month-old infant was noted to have vaginal bleeding that was accompanied by a discharged tumor fragment. The histological diagnosis was endodermal sinus tumor. Her serum alpha-fetoprotein (AFP) was increased to 358.7 ng/mL, and magnetic resonance imaging showed a 1.8 x 1.0 cm tumor in the vagina. She received combination chemotherapy with cyclophosphamide, pirarubicin, carboplatin, and etoposide. The tumor in the images disappeared and the serum level of AFP returned to the normal range after 2 cycles. Treatment was complete without surgical or radiological therapy. More than 45 months after the completion of chemotherapy, she is alive without signs of recurrence.
authors.affiliation: Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. shinkoda@nk-cc.go.jp
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shinkoda
authors.forename: Satoru
authors.initials: S
authors.lastname: Tanaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Ijichi
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nonaka
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tanabe
authors.forename: Takuro
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Syuji
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Tatsuru
authors.initials: T
authors.lastname: Kaji
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tahara
authors.forename: Hideo
authors.initials: H
authors.lastname: Takamatsu
authors.forename: Kohji
authors.initials: K
authors.lastname: Nagata
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018240:Endodermal Sinus Tumor / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D014625:Vaginal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology