title: Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy.
abstract: Hypoxic-ischemic encephalopathy (HIE) in neonates results in long-term disabilities. Stem cell therapy may offer an attractive treatment for HIE. Multipotent astrocytic stem cells (MASCs) from mice transplanted into a rat model of hypoxia-ischemia (HI) survived the transplantation and showed signs of migration towards the injured cortex. Some MASCs around the injured cortex differentiated into neuronal and astrocytic phenotypes. MASCs transplanted into non-ischemic pups survived but retained their astrocytic phenotype. These data suggest that transplanted MASCs can survive and differentiate into neurons and astrocytes in the post-injury milieu of the neonatal brain injured by HI.
authors.affiliation: McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
authors.forename: Tong
authors.initials: T
authors.lastname: Zheng
authors.forename: Candace
authors.initials: C
authors.lastname: Rossignol
authors.forename: Avital
authors.initials: A
authors.lastname: Leibovici
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Anderson
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Steindler
authors.forename: Michael D
authors.initials: MD
authors.lastname: Weiss
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D004195:Disease Models, Animal; D005455:Fluorescent Antibody Technique / Q000379:methods; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain / Q000601:surgery*; D051381:Rats; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*; D014404:Tubulin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014404:Tubulin