[Cutaneous lymphomas: classification and stage-adjusted therapy].
Cutaneous lymphomas are a heterogeneous group of clonal proliferations of T and B lymphocytes with various clinical manifestations and prognosis. The new EORTC WHO classification of cutaneous T- and B-cell lymphomas provides a uniform nomenclature based on clinical, histologic, cytologic and molecular biological features. Accurate classification is a prerequisite for uniform therapeutic concepts. For office-based dermatologist, more than 50% of the therapies deal with classic forms of cutaneous T-cell lymphomas, type mycosis fungoides. In recent years the paradigm for the therapy of cutaneous T-cell lymphomas has changed. Since early aggressive treatment with cytostatic agents does not increase the response rate or overall survival, a commonly accepted stage-adapted therapy is recommended. In this review the current status of the therapy of cutaneous lymphoma is described in detail.
Stadler
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Hautklinik am Klinikum Minden, Portastrasse 7-9, 32423 Minden, Deutschland. hautklinik@klinikum-minden.de
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D038801:International Classification of Diseases; D009367:Neoplasm Staging / Q000295:instrumentation* / Q000379:methods*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D012878:Skin Neoplasms / Q000145:classification / Q000188:drug therapy* / Q000473:pathology*
D000970:Antineoplastic Agents