title: Paroxetine treatment of primary insomnia in older adults.
abstract: OBJECTIVE
  The goal of this study was to test the efficacy of paroxetine for primary insomnia in older adults.
  
  
  METHODS
  Adults over age 55 with primary insomnia were randomly assigned to six weeks of double-blind treatment with paroxetine (N = 14) or placebo (N = 13). Outcome measures included persistence or resolution of insomnia; weekly diary measures of sleep quality, daytime alertness, and mood; and pre-/postpolysomnographic measures of sleep latency, wake time after sleep onset, and sleep efficiency.
  
  
  RESULTS
  Although weekly diary-based measures showed improved subjective sleep quality, daytime alertness, and mood with paroxetine, the authors observed no effect on sleep efficiency or categorical response rates.
  
  
  CONCLUSIONS
  Paroxetine appears to be ineffective for treating primary insomnia in old age.
authors.affiliation: Advanced Center for Interventions and Services Research for Late-Life Mood Disorders (ACISR/LLMD) and the John A. Hartford Center of Excellence in Geriatric Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA. Reynoldscf@upmc.edu
authors.forename: Charles F
authors.initials: CF
authors.lastname: Reynolds
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Buysse
authors.forename: Mark D
authors.initials: MD
authors.lastname: Miller
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Pollock
authors.forename: Martica
authors.initials: M
authors.lastname: Hall
authors.forename: Sati
authors.initials: S
authors.lastname: Mazumdar
mesh_terms: D000368:Aged; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000627:therapeutic use*; D017286:Polysomnography; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors; D017211:Treatment Failure
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors