title: G-CSF in acute myocardial infarction - experimental and clinical findings.
abstract: Early data from clinical studies suggest that intracoronary injection of autologous progenitor cells may beneficially affect postinfarction remodeling and perfusion. Beyond intracoronary infusion of autologous bone marrow mononuclear CD34+ cells (MNCCD34+), mobilization of stem cells by G-CSF has recently attracted attention because of various advantages such as the noninvasive nature of MNCCD34+ mobilization by subcutaneous injections. It is the aim of the present work to give an overview about the current experimental and clinical findings of G-CSF treatment in acute myocardial infarction.
authors.affiliation: Department of Medicine, Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Rostock, Germany. hueseyin.ince@med.uni-rostock.de
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ince
authors.forename: Michael
authors.initials: M
authors.lastname: Petzsch
authors.forename: Tim C
authors.initials: TC
authors.lastname: Rehders
authors.forename: Simone
authors.initials: S
authors.lastname: Dunkelmann
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Nienaber
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007279:Injections, Subcutaneous; D009203:Myocardial Infarction / Q000628:therapy*; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor