GnRH receptor signalling to ERK: kinetics and compartmentalization.
Many hormones, neurotransmitters and growth factors influence their target cells by activation of mitogen-activated protein kinase cascades. The consequences of such activation reflect not only the magnitude, but also the kinetics and cellular compartmentalization of kinase activity. Gonadotropin-releasing hormone (GnRH) receptors are seven-transmembrane receptors that have undergone a period of rapidly accelerated molecular evolution in which the advent of type I mammalian GnRH receptors has been associated with the loss of the carboxyl-terminal tail, a structure present in all other seven-transmembrane receptors. Here, we review spatiotemporal aspects of extracellular-signal-regulated kinase activation by gonadotropin-releasing hormone receptors, emphasizing how the absence or presence of the carboxyl-terminal tail dictates the receptors' ability to engage and signal via arrestins.
Caunt
Christopher James
CJ
University of Bristol, Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Whitson Street, Bristol BS1 3NY, UK.
Finch
Ann R
AR
Sedgley
Kathleen R
KR
McArdle
Craig A
CA
D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D011966:Receptors, LHRH / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
D011966:Receptors, LHRH; D048049:Extracellular Signal-Regulated MAP Kinases