title: beta(2)-Microglobulin amyloidosis caused spinal cord compression in a long-term haemodialysis patient.
abstract: METHODS
  A case report of cervical myelopathy caused by epidural beta (2)-microglobulin (beta2m) amyloid deposits in a 50-year-old woman with haemodialysis treatment.
  
  
  OBJECTIVE
  Long-term haemodialysis in patients with end-stage renal disease leads to several complications based on beta2m deposits, which can affect, in the cervical spine, the intervertebral disk, and in rare cases, they may compress the spinal cord and nerves. The objective of this report is to describe the clinical and radiological follow-up preceding the indispensable surgical excision of an amyloid mass in a 50-year-old woman with haemodialysis treatment. Long-term postoperative cervicalgia owing to subcondylian bone cyst-associated atlanto-occipital instability is also described and discussed.
  
  
  METHODS
  Department of Neurosurgery A, Hop Pellegrin, Bordeaux, France.
  
  
  METHODS
  We present a clinical case of a patient with spinal cord compression. The patient was treated by surgical excision of an amyloid mass subsequent to a C2-C3 laminectomy. The patient experienced clinical improvement with a regression of all of her neurological symptoms. Histological findings confirm the diagnosis of beta2m amyloid deposition. However, 5 years after surgery the subcondylian bone cysts were still observed and atlanto-occipital instability required her to wear a minerva.
  
  
  CONCLUSIONS
  Our case report confirms that surgical excision of beta2m epidural deposits is necessary and relevant when neurological prognosis is discussed, and that pain is still the major symptom of disease evolution. The use of high-flux synthetic membranes could decrease the beta2m blood level and early renal graft is the only method to prevent such complications.
authors.affiliation: Department of Neurosurgery A, University Hospital of Bordeaux, CHU Pellegrin, Bordeaux, France.
authors.forename: J-R
authors.initials: JR
authors.lastname: Vignes
authors.forename: S
authors.initials: S
authors.lastname: Eimer
authors.forename: R
authors.initials: R
authors.lastname: Dupuy
authors.forename: E
authors.initials: E
authors.lastname: Donois
authors.forename: D
authors.initials: D
authors.lastname: Liguoro
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D007691:Medullary Sponge Kidney / Q000628:therapy; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D013117:Spinal Cord Compression / Q000175:diagnosis* / Q000209:etiology* / Q000601:surgery; D001613:beta 2-Microglobulin / Q000378:metabolism*
chemical_list: D001613:beta 2-Microglobulin