Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?
Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.
Verge
Carmen
C
Clinical Pharmacology Service, Virgen de la Victoria University Hospital, Málaga, Spain.
Lucena
M Isabel
MI
López-Torres
Enrique
E
Puche-Garcia
M José
MJ
Fraga
Enrique
E
Romero-Gomez
Manuel
M
Andrade
Raúl J
RJ
D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D003484:Cyanamide / Q000009:adverse effects*; D004221:Disulfiram / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000427:Alcohol Deterrents; D003484:Cyanamide; D004221:Disulfiram