title: Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD.
abstract: OBJECTIVE
  It is not well known whether there is heterogeneity in the airway dimensions at different anatomic locations in individual patients with COPD. The first objective was to compare airway dimensions of the basal segment bronchus between COPD patients and healthy controls. The second and third objectives were to compare the airway dimensions in two anatomic locations, and to investigate the relationship between CT measurements and pulmonary function among COPD patients.
  
  
  METHODS
  Thirty males with COPD (aged 68.7 +/- 8.1 years) and 18 healthy males (aged 64.9 +/- 14.0 years) were enrolled in the study. COPD was diagnosed according to the criteria of the Global Initiative for Obstructive Lung Disease Workshop Report. Pulmonary function tests and CT scans were performed on all subjects. Airway dimensions and lung attenuation were automatically determined using methods that were validated with a phantom.
  
  
  RESULTS
  Age, smoking index and height did not significantly differ between the COPD patients and healthy controls. The COPD patients had a significantly thicker airway wall than healthy controls. Among the COPD patients, there were no significant differences in the airway dimensions of bronchi in different segments; however, the airway and lung attenuation measurements of the lower lung field were more strongly correlated with FEV(1) than those of the upper lung field.
  
  
  CONCLUSIONS
  Patients with COPD had no significant heterogeneity in airway dimensions at different anatomic locations. The airway and lung attenuation measurements of the lower lung field were more strongly correlated with airflow limitation than those of the upper lung field.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kawahara 54, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ohara
authors.forename: Toyohiro
authors.initials: T
authors.lastname: Hirai
authors.forename: Susumu
authors.initials: S
authors.lastname: Sato
authors.forename: Atsuyasu
authors.initials: A
authors.lastname: Sato
authors.forename: Michiyoshi
authors.initials: M
authors.lastname: Nishioka
authors.forename: Shigeo
authors.initials: S
authors.lastname: Muro
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000368:Aged; D001980:Bronchi / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology* / Q000503:physiopathology; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed