title: Evolution of pulmonary surfactants for the treatment of neonatal respiratory distress syndrome and paediatric lung diseases.
abstract: This review documents the evolution of surfactant therapy, beginning with observations of surfactant deficiency in respiratory distress syndrome, the basis of exogenous surfactant treatment and the development of surfactant-containing novel peptides patterned after SP-B. We critically analyse the molecular interactions of surfactant proteins and phospholipids contributing to surfactant function.
  
  
  CONCLUSIONS
  Peptide-containing surfactant provides clinical efficacy in the treatment of respiratory distress syndrome and offers promise for treating other lung diseases in infancy.
authors.affiliation: Department of Neonatology, Poznan University of Medical Sciences, Poznan, and Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Mazela
authors.forename: T Allen
authors.initials: TA
authors.lastname: Merritt
authors.forename: Janusz
authors.initials: J
authors.lastname: Gadzinowski
authors.forename: Sunil
authors.initials: S
authors.lastname: Sinha
mesh_terms: D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005233:Fatty Alcohols / Q000627:therapeutic use; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal / Q000639:trends; D008171:Lung Diseases / Q000188:drug therapy; D010455:Peptides / Q000627:therapeutic use; D010715:Phosphatidylglycerols / Q000627:therapeutic use; D010743:Phospholipids / Q000627:therapeutic use; D011506:Proteins / Q000627:therapeutic use; D011650:Pulmonary Alveoli / Q000502:physiology; D037661:Pulmonary Surfactant-Associated Proteins / Q000502:physiology / Q000627:therapeutic use*; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D005233:Fatty Alcohols; D010455:Peptides; D010715:Phosphatidylglycerols; D010743:Phospholipids; D011506:Proteins; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; C502722:lucinactant