Epidemiology and outcome of Rhodotorula fungemia in a tertiary care hospital.
We reviewed demographic data, risk factors, treatment, and outcomes associated with Rhodotorula fungemia in a tertiary care hospital during 2002-2005. Rhodotorula species caused fungemic episodes in 7 patients during the 4-year period that we studied. The most common predisposing factors were patients with hematological and solid malignancy receiving corticosteroids and cytotoxic drugs, the presence of central venous catheters, and the use of broad-spectrum antibiotics. Because of Rhodotorula species's intrinsic resistance to triazole and echinocandin antifungal agents, patients receiving fluconazole and caspofungin might be susceptible to the development of breakthrough Rhodotorula fungemia.
Lunardi
Luciano W
LW
Section of Infectious Diseases and Microbiology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Aquino
Valerio R
VR
Zimerman
Ricardo A
RA
Goldani
Luciano Z
LZ
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000077336:Caspofungin; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002648:Child; D025141:Drug Resistance, Fungal; D054714:Echinocandins; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D016469:Fungemia / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D006761:Hospitals; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D010456:Peptides, Cyclic / Q000627:therapeutic use; D012189:Retrospective Studies; D012248:Rhodotorula / Q000187:drug effects; D012307:Risk Factors; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D015725:Fluconazole; D000077336:Caspofungin