Riboswitches: fold and function.
Riboswitches in the 5'-untranslated regions of mRNAs cotranscriptionally couple ligand binding and gene regulation. In this issue of Chemistry & Biology, Lemay et al. describe folding of a key tertiary interaction in the adenine riboswitch and its mechanistic consequences.
Gilbert
Sunny D
SD
Department of Chemistry and Biochemistry, University of Colorado-Boulder, Campus Box 215, Boulder, CO 80309, USA.
Batey
Robert T
RT
D020121:5' Untranslated Regions / Q000502:physiology*; D000225:Adenine / Q000737:chemistry / Q000502:physiology*; D001665:Binding Sites; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology; D008024:Ligands; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology
D020121:5' Untranslated Regions; D008024:Ligands; D014157:Transcription Factors; D012313:RNA; D000225:Adenine