title: HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy.
abstract: The Human Proteome Organisation (HUPO) initiated several projects focusing on the proteome analysis of distinct human organs. The Brain Proteome Project (BPP) is the initiative dedicated to the brain, its development and correlated diseases. Two pilot studies have been performed aiming at the comparison of techniques, laboratories and approaches. With the help of the results gained, objective data submission, storage and reprocessing workflow have been established. The biological relevance of the data will be drawn from the inter-laboratory comparisons as well as from the re-calculation of all data sets submitted by the different groups. In the following, results of the single groups as well as the centralised reprocessing effort will be summarised and compared, showing the added value of this concerted work.
authors.affiliation: Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany. Michael.Hamacher@rub.de
authors.forename: Michael
authors.initials: M
authors.lastname: Hamacher
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
authors.forename: Georg
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authors.lastname: Arnold
authors.forename: Albert
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authors.lastname: Becker
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authors.lastname: Blüggel
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authors.lastname: Fröhlich
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authors.lastname: Fountoulakis
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authors.lastname: van Hall
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authors.forename: Jianguo
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authors.lastname: Ji
authors.forename: Juango
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authors.lastname: Ji
authors.forename: Hans
authors.initials: H
authors.lastname: Kretzschmar
authors.forename: Piotr
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authors.lastname: Lewczuk
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authors.lastname: Lubec
authors.forename: Katrin
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authors.lastname: Marcus
authors.forename: Lennart
authors.initials: L
authors.lastname: Martens
authors.forename: Nadine
authors.initials: N
authors.lastname: Palacios Bustamante
authors.forename: Young Mok
authors.initials: YM
authors.lastname: Park
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Pennington
authors.forename: Johan
authors.initials: J
authors.lastname: Robben
authors.forename: Kai
authors.initials: K
authors.lastname: Stühler
authors.forename: Kai A
authors.initials: KA
authors.lastname: Reidegeld
authors.forename: Peter
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authors.lastname: Riederer
authors.forename: Jean
authors.initials: J
authors.lastname: Rossier
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Sanchez
authors.forename: Michael
authors.initials: M
authors.lastname: Schrader
authors.forename: Christian
authors.initials: C
authors.lastname: Stephan
authors.forename: Danilo
authors.initials: D
authors.lastname: Tagle
authors.forename: Herbert
authors.initials: H
authors.lastname: Thiele
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jens
authors.initials: J
authors.lastname: Wiltfang
authors.forename: Jong Shin
authors.initials: JS
authors.lastname: Yoo
authors.forename: Chenggang
authors.initials: C
authors.lastname: Zhang
authors.forename: Joachim
authors.initials: J
authors.lastname: Klose
authors.forename: Helmut E
authors.initials: HE
authors.lastname: Meyer
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D019295:Computational Biology; D030562:Databases, Protein; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism; D005260:Female; D006801:Humans; D051379:Mice; D015337:Multicenter Studies as Topic; D010865:Pilot Projects; D020543:Proteome / Q000032:analysis* / Q000378:metabolism
chemical_list: D020543:Proteome