Human P450s in the metabolism of drugs: molecular modelling of enzyme-substrate interactions.
The importance of cytochrome P450 enzymes to the Phase I metabolism of drugs and other xenobiotics is reviewed in the light of current knowledge. The relatively new technologies of molecular biology, protein crystallography and molecular modelling have been applied to these enzymes and this endeavour is proving extremely useful for novel compound development.
Lewis
David F V
DF
University of Surrey, School of Biomedical and Molecular Sciences, Guildford, Surrey, GU2 7XH, UK. d.Lewis@surrey.ac.uk
D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008958:Models, Molecular; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013379:Substrate Specificity / Q000502:physiology
D007527:Isoenzymes; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System