title: Simultaneous biodetoxification of S, N, and O pollutants by engineering of a carbazole-degrading gene cassette in a recombinant biocatalyst.
abstract: The gene cassette encoding enzymes responsible for degrading carbazole to anthranilic acid was introduced into a dibenzothiophene degrader. The resultant strain, Rhodococcus erythropolis XPDN, could simultaneously transform the model pollutants dibenzothiophene, carbazole, and dibenzofuran to nontoxic metabolites and may have an application potential for bioremediation.
authors.affiliation: State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Cuiqing
authors.initials: C
authors.lastname: Ma
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Zhou
authors.forename: Shanshan
authors.initials: S
authors.lastname: Zhu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Jingyao
authors.initials: J
authors.lastname: Qu
authors.forename: Fuli
authors.initials: F
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002227:Carbazoles / Q000737:chemistry / Q000378:metabolism*; D004785:Environmental Pollutants / Q000737:chemistry / Q000378:metabolism*; D005818:Genetic Engineering / Q000379:methods*; D009584:Nitrogen / Q000737:chemistry / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism; D011995:Recombination, Genetic; D012240:Rhodococcus / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D013455:Sulfur / Q000737:chemistry / Q000378:metabolism; D013876:Thiophenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001572:Benzofurans; D002227:Carbazoles; D004785:Environmental Pollutants; D013876:Thiophenes; D013455:Sulfur; C023614:dibenzofuran; D009584:Nitrogen; D010100:Oxygen; C016366:dibenzothiophene