Acute myopia and angle closure caused by topiramate, a drug used for prophylaxis of migraine.
Acute transient myopia with shallowing of the anterior chamber is a rare idiosyncratic response to many systemic and topical medications, including sulfonamides. Several such cases have been reported in the past, but are less frequently reported in recent times. We report a case of acute progressive myopia and bilateral angle closure due to Topiramate--a drug used for epilepsy and migraine prophylaxis.
Desai
Charuta Mandke
CM
Department of Ophthalmology, MGM Hospital, Kamothe, Navi Mumbai, Maharashtra, India.
Ramchandani
Suresh J
SJ
Bhopale
Sunil G
SG
Ramchandani
Sushama S
SS
D000328:Adult; D000867:Anterior Chamber / Q000000981:diagnostic imaging / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008881:Migraine Disorders / Q000517:prevention & control*; D009216:Myopia / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D012029:Refraction, Ocular / Q000187:drug effects; D000077236:Topiramate; D014463:Ultrasonography
D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose