title: Pertussis vaccine effectiveness in reducing clinical disease, transmissibility and proportion of cases with a positive culture after household exposure in Brazil.
abstract: In household outbreaks of pertussis, children <5 years of age who received at least 3 doses of vaccine had 12% less clinical disease; vaccinated cases were 63% less culture-confirmed and transmitted infection to 62% fewer contacts. Three doses of pertussis vaccine are likely to decrease circulation of Bordetella pertussis by reducing the proportion of bacteriologically positive cases and transmissibility.
authors.affiliation: Pediatric Infectious Diseases Service, Federal University of Pernambuco, Pernambuco, Brazil. psjn@terra.com.br
authors.forename: Paulo N
authors.initials: PN
authors.lastname: Baptista
authors.forename: Vera
authors.initials: V
authors.lastname: Magalhães
authors.forename: Laura C
authors.initials: LC
authors.lastname: Rodrigues
authors.forename: MariaAngela W
authors.initials: MW
authors.lastname: Rocha
authors.forename: Analíria M
authors.initials: AM
authors.lastname: Pimentel
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010567:Pertussis Vaccine / Q000627:therapeutic use*; D014917:Whooping Cough / Q000517:prevention & control* / Q000635:transmission
chemical_list: D010567:Pertussis Vaccine