[RNA binding proteins in the RNA interference phenomenon].
The ability of short RNAs (21-27 nucleotides) to silence genes containing homologous nucleotide sequences is related to RNA silencing. The pathways of short RNAs (siRNA and microRNA) biogenesis from their precursors, double stranded and hairpin RNAs respectively, are briefly reviewed. The functioning of specific RNA binding domains found for the first time in the proteins operating in RNA interference (RNAi) is considered. The interactions of these domains with the earlier well known RNA binding modules in RNAi proteins are described.
Kotel'nikov
R N
RN
Shpiz
S G
SG
Kalmykova
A I
AI
Gvozdev
V A
VA
D000818:Animals; D020868:Gene Silencing; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009690:Nucleic Acid Conformation; D020365:RNA Helicases / Q000378:metabolism; D034622:RNA Interference / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional; D012330:RNA, Double-Stranded / Q000378:metabolism; D034741:RNA, Small Interfering / Q000502:physiology; D016601:RNA-Binding Proteins / Q000502:physiology*; D034743:RNA-Induced Silencing Complex / Q000502:physiology; D043244:Ribonuclease III / Q000378:metabolism
D035683:MicroRNAs; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering; D016601:RNA-Binding Proteins; D034743:RNA-Induced Silencing Complex; D043244:Ribonuclease III; D020365:RNA Helicases