Systemic allergic reactions to aprotinin injection around the Achilles tendon.
Local aprotinin injections are used in the treatment of chronic tendinopathy. Severe allergic reactions, although uncommon, have been reported. We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.
Rukin
Nicholas J
NJ
Department of Trauma and Orthopaedic Surgery, Keele University School of Medicine, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire, England.
Maffulli
Nicola
N
D000125:Achilles Tendon / Q000293:injuries*; D007611:Aprotinin / Q000009:adverse effects* / Q000276:immunology; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008875:Middle Aged; D052256:Tendinopathy / Q000188:drug therapy; D014361:Trypsin Inhibitors / Q000009:adverse effects* / Q000276:immunology
D014361:Trypsin Inhibitors; D007611:Aprotinin