title: A comparison of neurocognitive function in nonsmoking and chronically smoking short-term abstinent alcoholics.
abstract: Approximately 70-90% of individuals in North America seeking treatment for alcoholism are chronic smokers. A growing body of evidence suggests chronic cigarette smoking alone adversely affects neurocognition in adults. However, few studies on the neurocognitive function of short-term abstinent alcoholics have specifically considered the potential effects of chronic cigarette smoking. In this study, 20 nonsmoking recovering alcoholics (nsRA) and 22 actively smoking recovering alcoholics (sRA) participants, matched on age and education, were contrasted on a comprehensive neurocognitive battery after 34+/-9 days of abstinence. nsRA were superior to sRA on measures of auditory-verbal learning and memory, processing speed, cognitive efficiency, and static postural stability. These group differences were not a function of group disparities in age, education, estimated premorbid verbal intelligence, lifetime alcohol consumption, or other measured comorbid psychiatric or medical factors. In sRA, longer smoking duration was negatively correlated with executive skills, visuospatial learning, general cognitive efficiency, and static postural stability. These results indicate that greater consideration of the potential neurobiological effects of current chronic smoking on neurocognitive functioning is warranted in studies of alcoholism and other conditions where smoking is a common comorbid factor.
authors.affiliation: San Francisco Veterans Administration Medical Center, Center for Imaging of Neurodegenerative Disease, San Francisco, CA 94116, USA. timothy.durazzo@ucsf.edu
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Durazzo
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Rothlind
authors.forename: Stefan
authors.initials: S
authors.lastname: Gazdzinski
authors.forename: Peter
authors.initials: P
authors.lastname: Banys
authors.forename: Dieter J
authors.initials: DJ
authors.lastname: Meyerhoff
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000523:psychology*; D003071:Cognition; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D012907:Smoking / Q000009:adverse effects* / Q000523:psychology; D013695:Temperance / Q000523:psychology*