title: Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics.
abstract: Metanephric adenoma is a rare benign tumor of the kidney. It is considered to be derived from embryonic renal tissue and to be the benign counterpart of the Wilms tumor. Although its imaging findings and immunohistochemistry are nonspecific, it has a typical microscopic morphology. We describe a case of a 24-year-old primigravida who presented in the 28th week of pregnancy with lower back pain, fever, malaise, and anemia. At renal ultrasonography and magnetic resonance imaging, a hemorrhagic tumor of 10 cm in diameter originating from the right kidney was seen. Based on the imaging findings, the diagnosis of a cystic renal cell carcinoma with recent hemorrhage was suggested, and a radical nephrectomy was performed. Pathologic examination concluded to a metanephric adenoma. The further pregnancy went on well. The karyotype of the tumor was 46,XX,t(1;22)(q22;q13),t(15;16)(q21;p13). To our knowledge, this is the first report on these chromosomal abnormalities in metanephric adenoma.
authors.affiliation: Department of Morphology and Molecular Pathology, University Hospitals Leuven, B-3000 Leuven, Belgium. evelyne.lerut@uz.kuleuven.ac.be
authors.forename: Evelyne
authors.initials: E
authors.lastname: Lerut
authors.forename: Tania
authors.initials: T
authors.lastname: Roskams
authors.forename: Steven
authors.initials: S
authors.lastname: Joniau
authors.forename: Raymond
authors.initials: R
authors.lastname: Oyen
authors.forename: Ruth
authors.initials: R
authors.lastname: Achten
authors.forename: Hendrik
authors.initials: H
authors.lastname: Van Poppel
authors.forename: Maria
authors.initials: M
authors.lastname: Debiec-Rychter
mesh_terms: D000236:Adenoma / Q000235:genetics* / Q000473:pathology*; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007668:Kidney / Q000196:embryology / Q000473:pathology; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009392:Nephrectomy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics* / Q000473:pathology*; D014463:Ultrasonography; D009396:Wilms Tumor / Q000473:pathology