Pain-relieving effects of acupuncture and electroacupuncture in an animal model of arthritic pain.
The effects of acupuncture and electroacupuncture on an animal model of arthritic pain were examined. Under halothane anesthesia, arthritic pain was induced by the injection of carrageenan into the knee joint cavity of male Sprague-Dawley rats. Behavioral performance was tested before and after the termination of acupuncture or electroacupuncture. Electrophysiologically, the responses of afferents to a movement cycle were recorded before and after acupuncture or electroacupuncture. After the acupuncture procedure, the weight-bearing force of the rats was significantly improved and the neural responses to noxious movement stimulation were reduced. Electroacupuncture significantly improved weight-bearing behavior and inhibited neural responses of articular afferents to noxious stimulation. These results indicate that acupuncture and electroacupuncture may provide a potent strategy in relieving arthritic pain.
Oh
Jin Hwan
JH
Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Bai
Sun Joon
SJ
Cho
Zang-Hee
ZH
Han
Hee Chul
HC
Min
Sun Seek
SS
Shim
Insop
I
Lee
Hye-Jung
HJ
Lee
Hyangsook
H
Lee
Bae Hwan
BH
D015669:Acupuncture Points; D015670:Acupuncture Therapy / Q000379:methods*; D000704:Analysis of Variance; D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000150:complications*; D002351:Carrageenan; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D008297:Male; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D010146:Pain / Q000209:etiology* / Q000503:physiopathology; D059408:Pain Management; D010147:Pain Measurement / Q000379:methods; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D013997:Time Factors; D016474:Weight-Bearing / Q000502:physiology
D002351:Carrageenan