An environmentally friendly synthetic method of 1,2-dihydroisoquinoline frameworks via three-component reaction with o-alkynylbenzaldehydes, primary amines, and pronucleophiles.
Three-component reactions with ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles (Nu-H), such as CHCl3, proceeded to give 1,2-dihydroisoquinoline derivatives in good to high yields in the absence of any catalysts under mild reaction conditions.
Asao
Naoki
N
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. asao@mail.tains.tohoku.ac.jp
Iso
Kentaro
K
Yudha S
Salprima
S