title: Chronically elevated corticosterone in the amygdala increases corticotropin releasing factor mRNA in the dorsolateral bed nucleus of stria terminalis following duress.
abstract: Elevated corticosterone in the amygdala leads to cautious avoidance behaviors on the elevated plus maze. The current study examined the effect of elevated corticosterone in the amygdala on corticotropin releasing factor (CRF) mRNA levels in the bed nuclei of stria terminalis (BNST). Exposure to the elevated plus maze increased CRF mRNA in both the dorsolateral and ventrolateral BNST. Corticosterone implants in the amygdala potentiated this effect in the dorsolateral, but not ventrolateral BNST. Corticosterone also resulted in an increased number of neurons expressing CRF in the dorsolateral BNST in response to the behavioral stimuli.
authors.affiliation: Department of Biological Sciences, Towson University, Towson, MD, USA. jshepard@towson.edu
authors.forename: Jack D
authors.initials: JD
authors.lastname: Shepard
authors.forename: Jay
authors.initials: J
authors.lastname: Schulkin
authors.forename: Dean A
authors.initials: DA
authors.lastname: Myers
mesh_terms: D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal; D003345:Corticosterone / Q000378:metabolism / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D018782:Maze Learning / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012686:Septal Nuclei / Q000378:metabolism*; D013315:Stress, Psychological / Q000209:etiology / Q000378:metabolism / Q000473:pathology
chemical_list: D012333:RNA, Messenger; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone