title: Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.
abstract: OBJECTIVE
  The present study aimed to evaluate the effect of metformin exposure during pregnancy on neonates of polycystic ovarian syndrome (PCOS) patients.
  
  
  METHODS
  Neonatal outcomes of 33 women with PCOS treated with metformin during pregnancy were compared to neonatal outcomes of 66 normal healthy women in a retrospective case-control study.
  
  
  RESULTS
  The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls. After controlling for pregnancy complications, this observation became only marginally statistically significant.
  
  
  CONCLUSIONS
  Although metformin is an attractive option for induction of ovulation in PCOS patients, there is a need for more evidence related to its safety during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon, Israel. michalkovo@hotmail.com
authors.forename: Michal
authors.initials: M
authors.lastname: Kovo
authors.forename: Ariel
authors.initials: A
authors.lastname: Weissman
authors.forename: Dvir
authors.initials: D
authors.lastname: Gur
authors.forename: David
authors.initials: D
authors.lastname: Levran
authors.forename: Sigi
authors.initials: S
authors.lastname: Rotmensch
authors.forename: Marek
authors.initials: M
authors.lastname: Glezerman
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000453:epidemiology; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin