Effect of the C-terminus of murine S100A9 protein on experimental nociception.
Calcium-binding protein S100A9 induces antinociception in mice evaluated by the writhing test. Similarly, a peptide identical to the C-terminus of murine S100A9 (mS100A9p) inhibits the hyperalgesia induced by jararhagin, a metalloprotease. Thus, we investigated the effect of mS100A9p on different models used to evaluate nociception. mS100A9p induced a dose-dependent inhibitory effect on the writhing test, and on mechanical hyperalgesia induced by carrageenan. mS100A9p inhibited thermal hyperalgesia induced by carrageenan. mS100A9p did not modify the nociceptive response in hot plate or tail-flick tests. These data demonstrate that the C-terminus of S100A9 protein interferes with control mechanisms of inflammatory pain.
Dale
Camila Squarzoni
CS
Laboratory of Pathophysiology, Butantan Institute, Av. Vital Brazil 1500, São Paulo, SP 05503-900, Brazil.
Pagano
Rosana de Lima
Rde L
Paccola
Carina Cicconi
CC
Pinotti-Guirao
Tatiana
T
Juliano
Maria Aparecida
MA
Juliano
Luiz
L
Giorgi
Renata
R
D000818:Animals; D040502:Calgranulin B / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D002351:Carrageenan; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000188:drug therapy; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D040502:Calgranulin B; D010446:Peptide Fragments; D002351:Carrageenan