title: Natural course of macular retinoschisis in highly myopic eyes without macular hole or retinal detachment.
abstract: OBJECTIVE
  To investigate the natural course of macular retinoschisis in highly myopic patients.
  
  
  METHODS
  A prospective, observational case series.
  
  
  METHODS
  Seven consecutive patients (eight eyes) with macular retinoschisis without macular hole or retinal detachment determined by optical coherence tomography (OCT) were followed at least two years without surgical intervention. The changes in the OCT findings and best-corrected visual acuity (BCVA) were analyzed.
  
  
  RESULTS
  During follow-up, two eyes that had vitreoretinal adhesions developed a macular hole, one with and one without retinal detachment (RD), and two eyes without detectable vitreoretinal adhesion developed RD without a macular hole. BCVA in these four eyes was significantly reduced. The remaining four eyes did not develop complications, although the thickness of the macula increased significantly.
  
  
  CONCLUSIONS
  These findings suggest that macular retinoschisis might be a progressive condition, and that complications appeared to be related to the presence of vitreoretinal tractions.
authors.affiliation: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Shimada
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ohno-Matsui
authors.forename: Takayuki
authors.initials: T
authors.lastname: Baba
authors.forename: Soh
authors.initials: S
authors.lastname: Futagami
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokoro
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000150:complications / Q000503:physiopathology*; D011446:Prospective Studies; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D012167:Retinal Perforations / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D041441:Retinoschisis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity