title: Correlation of oxygen delivery with central venous oxygen saturation, mean arterial pressure and heart rate in piglets.
abstract: BACKGROUND
  Accurate assessment and monitoring of the cardiocirculatory function is essential during major pediatric and pediatric cardiac surgery. Invasive monitoring of cardiac output and oxygen delivery (DO(2)) is expensive and sometimes associated with adverse events. Measurement of central venous oxygen saturation (ScvO(2)) is less invasive and may reflect the DO(2). Therefore, we investigated the correlation of ScvO(2) with cardiac index (CI) and DO(2) and in comparison the more common monitored parameters heart rate (HR) and mean arterial pressure (MAP) with DO(2) in an animal experimental setting.
  
  
  METHODS
  In five fasted, anesthetized and mechanically ventilated piglets CI (transpulmonary thermodilution), venous and arterial blood gases, HR and MAP was measured during normal conditions, volume loading, inotropic support, and exsanguination.
  
  
  RESULTS
  In the five piglets 168 measurements could be performed. In a wide hemodynamic range (CI 22-335 ml x kg(-1) min(-1)) we found significant correlations of ScvO(2) with DO(2)) (r(2) = 0.91, P < 0.0001) and CI (r(2) = 0.88, P < 0.0001) and also between DO(2) and MAP (r = 0.86, P < 0.0001) and HR (r = 0.19, P < 0.05).
  
  
  CONCLUSIONS
  ScvO(2) is a better parameter for indirect estimation of DO(2) than MAP and heart rate. Measurement of ScvO(2) is simple and does not necessitate additional invasive techniques. In the clinical setting ScvO(2) should be used in combination with other standard vital parameters, i.e. MAP, central venous pressure, lactate, base excess, and urine output.
authors.affiliation: Zentrum Anästhesiologie, Medizinische Hochschule Hannover, Hannover, Germany. osthaus.alexander@mh-hannover.de
authors.forename: Wilhelm A
authors.initials: WA
authors.lastname: Osthaus
authors.forename: Dirk
authors.initials: D
authors.lastname: Huber
authors.forename: Carsten
authors.initials: C
authors.lastname: Beck
authors.forename: Anja
authors.initials: A
authors.lastname: Roehler
authors.forename: Gernot
authors.initials: G
authors.lastname: Marx
authors.forename: Hartmut
authors.initials: H
authors.lastname: Hecker
authors.forename: Robert
authors.initials: R
authors.lastname: Sümpelmann
mesh_terms: D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D010100:Oxygen / Q000378:metabolism*; D013552:Swine; D014680:Veins / Q000378:metabolism
chemical_list: D010100:Oxygen