Tissue-tropic effector T cells: generation and targeting opportunities.
The localization of effector T cells to extralymphoid tissues is crucial for the generation of an effective immune response, but it also underlies many autoimmune and inflammatory disorders. Recent studies have highlighted a central role for draining lymph nodes and environmentally imprinted dendritic cells in the generation of tissue-tropic effector T cells. Here, I outline our current understanding of the mechanisms that regulate the generation and localization of tissue-tropic effector T cells, and the potential ways in which these pathways can be exploited for immunotherapeutic purposes.
Agace
William W
WW
Immunology Section, Lund University, BMC I13, 22184 Lund, Sweden. william.agace@med.lu.se
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002465:Cell Movement; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*