Immunological effects of recombinant feline interferon-omega (KT-80) administration in the dog.
The immunological effects of recombinant feline interferon-omega (rFeIFN-omega ; KT-80, Toray) were examined on administration to healthy dogs. The activities of whole blood cells, macrophages, and natural killer cells were enhanced. Moreover, the whole blood activity was examined when KT-80 was administered to dogs which had been diagnosed as having natural canine parvovirus (CPV) infection. Only some cases in which the activity increased until 3 hr post-administration survived. These results suggest that rFeIFN-omega (KT-80) treatment enhanced the cellular immunity of normal dogs, and could exert significant therapeutic effects on only natural CPV infected dogs with induced continuous immunoenhancement.
Kuwabara
Masato
M
Department of Veterinary Radiology, College of Bioresource Science, Nihon University, Fujisawa, Kanagawa Japan. kuwabara@bru.nihon-u.ac.jp
Nariai
Youko
Y
Horiuchi
Yutaka
Y
Nakajima
Yuko
Y
Yamaguchi
Yu
Y
Horioka
Eriko
E
Kawanabe
Mikiko
M
Kubo
Takuya
T
Yukawa
Masayoshi
M
Sakai
Takeo
T
D000818:Animals; D001773:Blood Cells / Q000276:immunology; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy / Q000276:immunology; D004285:Dogs; D007111:Immunity, Cellular / Q000187:drug effects*; D007370:Interferon Type I / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D010322:Parvoviridae Infections / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D017993:Parvovirus, Canine / Q000187:drug effects; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology
D007370:Interferon Type I; D011994:Recombinant Proteins; C063743:interferon omega 1