title: Interobserver variability with the interpretation of thyroid FNA specimens showing predominantly Hürthle cells.
abstract: Fine-needle aspiration (FNA) is used for the diagnosis and triaging of thyroid lesions. Recently, it has been shown that the pathologic interpretation of selected thyroid specimens can show a high degree of interobserver variability (IV). Because Hürthle cells may be seen in neoplastic and nonneoplastic disease, we investigated whether pathologists consistently interpret FNA specimens from these lesions. In the present study, 22 FNA specimens that showed Hürthle cells as the predominant cell type were reviewed by 7 pathologists. Cytologic features were assessed semiquantitatively. IV was calculated, and individual case diagnoses were compared with cytologic features. IV was high before diagnoses were collapsed into like diagnoses and triage recommendations (k = 0.17, 0.44, and 0.51, respectively). Overall cellularity, number of Hürthle cells, and number of lymphocytes all correlated with collapsed diagnostic agreement, and the number of air-dried rapid Romanowsky-stained slides, overall cellularity, number of Hürthle cells, and number of lymphocytes all correlated with collapsed triage recommendations.
authors.affiliation: Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA.
authors.forename: Edward B
authors.initials: EB
authors.lastname: Stelow
authors.forename: Carolyn
authors.initials: C
authors.lastname: Woon
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Atkins
authors.forename: Ricardo H
authors.initials: RH
authors.lastname: Bardales
authors.forename: Helen P
authors.initials: HP
authors.lastname: Cathro
authors.forename: Henry F
authors.initials: HF
authors.lastname: Frierson
authors.forename: Michael W
authors.initials: MW
authors.lastname: Stanley
authors.forename: Kay
authors.initials: K
authors.lastname: Savik
authors.forename: Stefan E
authors.initials: SE
authors.lastname: Pambuccian
mesh_terms: D044963:Biopsy, Fine-Needle; D002452:Cell Count; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D015588:Observer Variation; D024862:Oxyphil Cells / Q000473:pathology*; D013959:Thyroid Diseases / Q000145:classification / Q000453:epidemiology / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology*; D014218:Triage / Q000379:methods