title: Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum.
abstract: Two new 18-carbon norditerpenoid alkaloids, sinaconitines A (1) and B (2), together with two known alkaloids, ranaconitine (3) and lappaconitine (4), were isolated from the roots of Aconitum sinomontanum. Their structures were elucidated on the basis of spectral evidences and X-ray crystallographic analysis for 1. Furthermore, the reversed 13C NMR assignments for C-10 and C-13 of 3, 4, puberanine, puberanidine and demethyllappaconitine were revised. Compounds 1-4 were evaluated for cyclooxygenase-2 (COX-2) enzyme inhibitory activity. However, they did not show any inhibition at 10 microM.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 ZuChongZhi Road, Shanghai 201203, China.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Tan
authors.forename: C-H
authors.initials: CH
authors.lastname: Tan
authors.forename: B-Q
authors.initials: BQ
authors.lastname: Ruan
authors.forename: S-H
authors.initials: SH
authors.lastname: Jiang
authors.forename: D-Y
authors.initials: DY
authors.lastname: Zhu
mesh_terms: D000107:Acetylation; D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D000470:Alkaloids; D004224:Diterpenes; C514663:sinaconitine A; C514664:sinaconitine B