title: Synthesis of certain new thiieno [2,3-d] pyrimidines as potential antitumor and radioprotective agents.
abstract: During research on anticancer and radioprotective heterocyclic compounds containing thiophene ring 5-10, 15, 19, thieno[2,3-d]pyrimidines 11-14 and biscompound having thieno[2,3-d]pyrimidine 18 were synthesized. The synthesized compounds were characterized by elemental ananlysis, IR, 1H-NMR and mass spectral data. Some of the obtained compounds showed interesting antitumor and radioprotective activities.
authors.affiliation: Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt. ghorabmoustafa@yahoo.com
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Ghorab
authors.forename: Fatma A
authors.initials: FA
authors.lastname: Ragab
authors.forename: Eman
authors.initials: E
authors.lastname: Noaman
authors.forename: Helmy I
authors.initials: HI
authors.lastname: Heiba
authors.forename: Marwa
authors.initials: M
authors.lastname: Galal
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005720:Gamma Rays; D005978:Glutathione / Q000097:blood; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D011743:Pyrimidines; D011837:Radiation-Protective Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione