Radio-frequency lesioning in brain tissue with coagulation-dependent thermal conductivity: modelling, simulation and analysis of parameter influence and interaction.
Radio-frequency brain lesioning is a method for reducing e.g. symptoms of movement disorders. A small electrode is used to thermally coagulate malfunctioning tissue. Influence on lesion size from thermal and electric conductivity of the tissue, microvascular perfusion and preset electrode temperature was investigated using a finite-element model. Perfusion was modelled as an increased thermal conductivity in non-coagulated tissue. The parameters were analysed using a 2(4)-factorial design (n=16) and quadratic regression analysis (n=47). Increased thermal conductivity of the tissue increased lesion volume, while increased perfusion decreased it since coagulation creates a thermally insulating layer due to the cessation of blood perfusion. These effects were strengthened with increased preset temperature. The electric conductivity had negligible effect. Simulations were found realistic compared to in vivo experimental lesions.
Johansson
Johannes D
JD
Department of Biomedical Engineering, Linköping University, 581 85, Linköping, Sweden. johjo@imt.liu.se
Eriksson
Ola
O
Wren
Joakim
J
Loyd
Dan
D
Wårdell
Karin
K
D001921:Brain / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D008959:Models, Neurological; D013814:Thermal Conductivity