title: Mixtures of triblock copolymers E(62)P(39)E(62) and E(137)S(18)E(137) potential for drug delivery from in situ gelling micellar formulations.
abstract: The gelation behaviour of concentrated micellar solutions of mixtures of a block copolymer of ethylene oxide and styrene oxide (E(137)S(18)E(137)) with one of ethylene oxide and propylene oxide (E(62)P(39)E(62)) has been investigated. Over a wide range of compositions, up to 90 wt.% E(137)S(18)E(137) in the mixture, gelation resembled that of solutions of E(62)P(39)E(62) alone, i.e. they gelled on heating from ambient to body temperature. In related experiments, using the aromatic drug griseofulvin as a comparative standard, it was demonstrated that solubilisation efficiency of dilute micellar solutions of the mixtures with 80 wt.% or more E(137)S(18)E(137) approached that of solutions of E(137)S(18)E(137) alone. Thus it was shown that the mixed system could have both the satisfactory solubilisation capacity of micellar solutions of E(137)S(18)E(137) and the desirable gelation characteristics of E(62)P(39)E(62), and so have potential for use in drug release applications involving in situ gelation.
authors.affiliation: Department of Organic and Inorganic Chemistry, Polymer Laboratory, Federal University of Ceará, CX 12200, CEP 60455-760, Fortaleza, Ceará, Brazil.
authors.forename: M Elenir N
authors.initials: ME
authors.lastname: Pinho
authors.forename: Flávia de M L L
authors.initials: Fde M
authors.lastname: Costa
authors.forename: Fernando B S
authors.initials: FB
authors.lastname: Filho
authors.forename: Nagila M P S
authors.initials: NM
authors.lastname: Ricardo
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Yeates
authors.forename: David
authors.initials: D
authors.lastname: Attwood
authors.forename: Colin
authors.initials: C
authors.lastname: Booth
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004852:Epoxy Compounds / Q000737:chemistry*; D005027:Ethylene Oxide / Q000737:chemistry*; D005782:Gels; D006118:Griseofulvin / Q000008:administration & dosage; D008823:Micelles
chemical_list: D000935:Antifungal Agents; D004852:Epoxy Compounds; D005782:Gels; D008823:Micelles; D006118:Griseofulvin; C013690:styrene oxide; D005027:Ethylene Oxide