title: Helicobacter pylori status and the extent of gastric atrophy do not affect ulcer healing after endoscopic submucosal dissection.
abstract: BACKGROUND
  Eradication therapy for Helicobacter pylori is effective in preventing peptic ulcer recurrence, but its efficacy in ulcer healing is still controversial. The effect of H. pylori on artificial ulcers after endoscopic resection is not known. The purpose of the present study was therefore to evaluate the influence of H. pylori infection on ulcer healing after endoscopic submucosal dissection (ESD).
  
  
  METHODS
  One hundred and 10 patients who underwent ESD for gastric tumors, and for whom the infection status of H. pylori was confirmed before treatment, were included. The healing stage was studied by endoscopy performed at 8 weeks after ESD. In addition, 73 patients whose serum pepsinogen (PG) was evaluated before ESD, were divided into three groups: PG positive (PGI<or=70 ng/mL and I/II<or=3 ng/mL), strongly positive (PGI<or=30 ng/mL and I/II<or=2 ng/mL) and negative, to study the influence of atrophic gastritis on ulcer healing.
  
  
  RESULTS
  Ulcer healing was observed in 85 patients (93%) who were H. pylori positive, and in 19 patients (100%) in whom H. pylori had been eradicated previously. Serum PG level had no influence on the healing process. Among 15 patients with ulceration or ulcer scar with the lesion, ulcer healing was observed in nine patients (60%), which was significantly low.
  
  
  CONCLUSIONS
  Infection status of H. pylori and the extent of gastric atrophy do not affect ulcer healing after ESD. Preoperative existence of fibrotic change in the submucosal layer may delay the healing process.
authors.affiliation: Department of Gastroenterology, University of Tokyo, Tokyo, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Kakushima
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Fujishiro
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yahagi
authors.forename: Shinya
authors.initials: S
authors.lastname: Kodashima
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakamura
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005757:Gastritis, Atrophic / Q000097:blood / Q000150:complications* / Q000473:pathology; D005773:Gastroscopy / Q000379:methods*; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D011379:Prognosis; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000097:blood / Q000150:complications / Q000601:surgery*; D014945:Wound Healing
chemical_list: D020116:Pepsinogen A