Organization of the peripheral fly eye: the roles of Snail family transcription factors in peripheral retinal apoptosis.
The periphery of the fly eye contains a number of concentrically arranged cellular specializations that are induced by Wingless (Wg) signaling from the surrounding head capsule (HC). One of these is the pigment rim (PR), which is a thick layer of pigment cells that lies directly adjacent to the HC and completely circumscribes the rest of the retina. Many of the cells of the PR are derived from presumptive pigment cells that previously surrounded peripheral ommatidia that subsequently died. Here, we describe the Wg-elicited expression of Snail family transcription factors in the eye periphery that directs the ommatidial death and subsequent PR formation. These transcription factors are expressed only in a subset of the ommatidial cells not including the photoreceptors. Yet, the photoreceptors die and, thus, a non-autonomous death signal is released from the Snail-family-expressing cells that direct the death of the photoreceptors. In addition, Wg also elicits a similar peripheral expression of Notum, an enzyme that limits the extent of Wg signaling. Furthermore, we describe a later requirement for Snail family proteins in the 2 degrees and 3 degrees pigment cells throughout the main body of the eye.
Lim
Hui-Ying
HY
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Tomlinson
Andrew
A
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics* / Q000254:growth & development; D005123:Eye / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D010858:Pigmentation / Q000235:genetics / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D012160:Retina / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051155:Wnt1 Protein
D029721:Drosophila Proteins; C456459:Notum protein, Drosophila; D011518:Proto-Oncogene Proteins; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D051155:Wnt1 Protein; C467520:esg protein, Drosophila; C000604451:sna protein, Drosophila; C074622:wg protein, Drosophila; C402787:wor protein, Drosophila