[Expression of RhoC protein in human primary hepatocellular carcinoma and its clinical significance].
To detect the expression of RhoC protein in human primary hepatocellular carcinoma (HCC) and pericancerous liver (PCL) tissues and its relation to HCC prognosis.



Immunohistochemical method was used to detect the expression of RhoC protein in HCC, PCL of 43 patients. Thirty-six patients were followed up after they received radical resection.



The expression of RhoC protein in HCC was significantly higher than that in PCL. Rhoc expression was increased in cases with poor differentiation, portal vascular invasion, unintact envelope and multiple masses. The survival analysis showed that HCC with lower RhoC protein expression had better clinical outcomes.



RhoC protein expression is correlated with infiltration and metastasis in HCC. RhoC protein can be used as a prognostic indicator for HCC.
Cai
Xiu-jun
XJ
General Surgery Department, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. cxjzu@hotmail.com
Xu
Guan-gen
GG
Shen
Bo
B
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis; D020741:rho GTP-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D000075024:rhoC GTP-Binding Protein
C066690:RHOC protein, human; D020741:rho GTP-Binding Proteins; D000075024:rhoC GTP-Binding Protein