title: Structure-activity relationships of triterpenoid saponins on fruiting body induction in Pleurotus ostreatus.
abstract: To elucidate the structure-activity relationships of saponin on fruiting body induction in Pleurotus ostreatus, monodesmosidic saponins comprising a triterpenoid and glucose residues were synthesized. Betulin, a triterpenoid present in Birch bark, was used as the aglycon. The fruiting body induction activity increased with the number of glucose residues, from one to four. The most active betulinic saponin was betulin-3-yl beta-D-(4-O-beta-D-maltotriosyl)-glucoside.
authors.affiliation: Department of Applied Microbiology, Forestry and Forest Products Research Institute, Tsukuba, Ibaraki, Japan. ymagae@ffpri.affrc.go.jp
authors.forename: Yumi
authors.initials: Y
authors.lastname: Magae
authors.forename: Seiji
authors.initials: S
authors.lastname: Ohara
mesh_terms: D048690:Fruiting Bodies, Fungal / Q000737:chemistry / Q000187:drug effects*; D008968:Molecular Conformation; D020076:Pleurotus / Q000737:chemistry / Q000187:drug effects*; D012503:Saponins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000094062:Betulinic Acid
chemical_list: D012503:Saponins; D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid