Renal tubular dysgenesis with atypical histology and in-utero exposure to naproxen sodium.
Renal tubular dysgenesis (RTD), a rare, lethal, autosomal recessive disorder, is characterised by short and poorly differentiated proximal convoluted tubules associated with oligohydramnios, Potter sequence and neonatal death from respiratory failure. We report an unusual case of neonatal anuria owing to RTD with normally formed lungs, in-utero exposure to naproxen sodium and atypical histology in that the glomeruli were not as crowded as usually seen in RTD. When there is anuria in an infant following birth in the context of a normal renal ultrasound and an absence of objective evidence of perinatal hypoxia, RTD should be considered.
Koklu
Esad
E
Department of Paediatrics, School of Medicine, Erciyes University, Kayseri, Turkey. esad@erciyes.edu.tr
Gurgoze
Metin
M
Akgun
Hulya
H
Ozturk
Mehmet Adnan
MA
Poyrazoglu
M Hakan
MH
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001002:Anuria / Q000151:congenital / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007687:Kidney Tubules, Proximal / Q000002:abnormalities* / Q000473:pathology; D008431:Maternal-Fetal Exchange; D009288:Naproxen / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen