Effect of lithium hydroxybutyrate on hemodynamics and respiration in rats with different resistance to hypoxia.
Acute experiments on narcotized rats showed that intravenous infusion of GABA derivative lithium hydroxybutyrate induced different changes in hemodynamic and respiratory parameters in animals with high and low resistance to hypoxia. Rats highly resistant to hypoxia better tolerated lithium hydroxybutyrate treatment compared to low resistant animals.
Sanotskaya
N V
NV
Laboratory for Pathophysiology of Respiration, Laboratory of Bioengineering, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Matsievskii
D D
DD
Lebedeva
M A
MA
D000222:Adaptation, Physiological; D000818:Animals; D004361:Drug Tolerance; D006439:Hemodynamics / Q000187:drug effects*; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D007262:Infusions, Intravenous; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000737:chemistry / Q000378:metabolism
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D005680:gamma-Aminobutyric Acid; C022826:lithium hydroxybutyrate