title: An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum.
abstract: A fusidane triterpene, 16-deacetoxy-7-beta-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all (1)H and (13)C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 microg/ml.
authors.affiliation: Hypha Discovery Ltd., School of Biosciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK.
authors.forename: Liam
authors.initials: L
authors.lastname: Evans
authors.forename: John N
authors.initials: JN
authors.lastname: Hedger
authors.forename: David
authors.initials: D
authors.lastname: Brayford
authors.forename: Michael
authors.initials: M
authors.lastname: Stavri
authors.forename: Eileen
authors.initials: E
authors.lastname: Smith
authors.forename: Gemma
authors.initials: G
authors.lastname: O'Donnell
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Gray
authors.forename: Gareth W
authors.initials: GW
authors.lastname: Griffith
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial; D005672:Fusidic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C516014:16-deacetoxy-7-beta-hydroxy-fusidic acid; D000900:Anti-Bacterial Agents; D014315:Triterpenes; D005672:Fusidic Acid