title: Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?
abstract: Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.
authors.affiliation: Clinical Pharmacology Service, Virgen de la Victoria University Hospital, Málaga, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Verge
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Lucena
authors.forename: Enrique
authors.initials: E
authors.lastname: López-Torres
authors.forename: M José
authors.initials: MJ
authors.lastname: Puche-Garcia
authors.forename: Enrique
authors.initials: E
authors.lastname: Fraga
authors.forename: Manuel
authors.initials: M
authors.lastname: Romero-Gomez
authors.forename: Raúl J
authors.initials: RJ
authors.lastname: Andrade
mesh_terms: D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D003484:Cyanamide / Q000009:adverse effects*; D004221:Disulfiram / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D000427:Alcohol Deterrents; D003484:Cyanamide; D004221:Disulfiram