Dietary chelators as antioxidant enzyme mimetics: implications for dietary intervention in neurodegenerative diseases.
Following recent reviews on the role of metal ions in oxidative stress and neurodegenerative diseases, this article reports advances in the study of dietary components for the control of these conditions. Poor metal ion homeostasis is credited with pathological roles in the progression of a number of disorders including Alzheimer's disease, Parkinson's disease and multiple sclerosis. Synthetic metal ion chelators continue to show promise as a new therapeutic approach for neurodegenerative disorders. Dietary chelators, unlike most vitamins, are, however, capable of negating or even reversing the roles of metal ions by: (i) decorporation of metal ions, (ii) redox silencing, (iii) dissolution of deposits, and (iv) generation of an antioxidant enzyme mimetic. This review gives a critical evaluation of recent progress in, and potential for, dietary control of neurodegeneration on the basis of the formation of antioxidant enzyme mimetics.
Hague
Theresa
T
School of Life Sciences, Kingston University, Kingston-upon-Thames, Surrey, UK.
Andrews
Paul L R
PL
Barker
James
J
Naughton
Declan P
DP
D000544:Alzheimer Disease / Q000178:diet therapy / Q000201:enzymology; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002374:Catalase / Q000502:physiology; D002614:Chelating Agents / Q000008:administration & dosage*; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007477:Ions; D008670:Metals / Q000378:metabolism; D009103:Multiple Sclerosis / Q000178:diet therapy / Q000201:enzymology; D019636:Neurodegenerative Diseases / Q000178:diet therapy* / Q000201:enzymology; D010300:Parkinson Disease / Q000178:diet therapy / Q000201:enzymology; D009195:Peroxidase / Q000502:physiology; D013482:Superoxide Dismutase / Q000502:physiology
D000975:Antioxidants; D002614:Chelating Agents; D007477:Ions; D008670:Metals; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase