title: Cell-adhesion inhibitors produced by a sea hare-derived Periconia sp. II. Absolute stereostructures of peribysins H and I.
abstract: Peribysins H (1) and I (2) have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using ID and 2D NMR techniques and some chemical transformations including the modified Mosher's method. These metabolites inhibited the adhesion of human-leukemia HL-60 cells to HUVEC.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Takatsuki, Japan. yamada@gly.oups.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Minoura
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Numata
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001048:Aplysia / Q000382:microbiology*; D016227:Benzoquinones / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects*; D042783:Endothelial Cells / Q000187:drug effects; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D047029:Lactams, Macrocyclic / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000378:metabolism*; D009284:Naphthols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017828:Rifabutin / Q000031:analogs & derivatives
chemical_list: D000903:Antibiotics, Antineoplastic; D016227:Benzoquinones; D005663:Furans; D047029:Lactams, Macrocyclic; D009284:Naphthols; C513063:peribysin H; C513062:peribysin I; D017828:Rifabutin; C020754:herbimycin