Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman.
BACKGROUND
Cutaneous lymphomas co-expressing CD56 and CD30 are very rare. They share a clinicopathological overlap with natural killer- (NK)/T-cell lymphomas and anaplastic large-cell lymphomas (ALCLs), two entities with widely disparate clinical behavior.


METHODS
We present a case of an immunocompetent 57-year-old Caucasian woman with a rapidly growing, angiodestructive and neuroinvasive primary cutaneous ALCL (PCALCL). The neoplastic population of large anaplastic CD30+ and CD56+ T cells was masked by a massive admixture of histiocytes and neutrophils. The partially ulcerated and pus-secreting tumor involved the forehead and scalp and was assessed as clinical stage IAE.


RESULTS
After chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone), the patient achieved a complete remission. Additionally, high-dose chemotherapy with autologous peripheral blood stem-cell transplantation was administered as a consolidation of complete remission, in which she has remained for 6 years.


CONCLUSIONS
This is the first CD30+ and CD56+ primary skin lymphoma to be reported on the head. The presented case carries a remarkable combination of clinicopathological features of PCALCL and NK-/T-cell lymphoma.
Boudova
Ludmila
L
Department of Pathology, Medical Faculty Hospital, Charles University, Pilsen, Czech Republic. boudova@medima.cz
Kazakov
Dmitry V
DV
Jindra
Pavel
P
Sima
Radek
R
Vanecek
Tomás
T
Kuntscher
Vilem
V
Vera
Vozobulova
V
Bouda
Jiri
J
Michal
Michal
M
D019002:CD56 Antigen / Q000032:analysis*; D005260:Female; D005546:Forehead; D006258:Head and Neck Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006644:Histiocytes / Q000166:cytology; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D012535:Scalp / Q000098:blood supply / Q000187:drug effects / Q000294:innervation / Q000473:pathology; D012878:Skin Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D033581:Stem Cell Transplantation
D019002:CD56 Antigen; D017730:Ki-1 Antigen