Gene expression profile of idiopathic thrombocytopenic purpura (ITP).
To search for novel mechanisms that contribute to the pathophysiology of idiopathic thrombocytopenic purpura (ITP), we determined the whole blood gene expression profile in five ITP patients and five control samples. Using DNA microarrays that contained 24,473 unique putative genes, we found 176 cDNAs that were strongly correlated with ITP. These included a cluster of interferon-regulated genes and TLR7, as well many less-well characterized genes which are candidates for further study. We believe this approach is likely to yield new insights into our understanding of the molecular pathophysiology of ITP.
Sood
Ruchira
R
Department of Pathology, Stanford School of Medicine, Stanford, California 94305-5324, USA.
Wong
Wendy
W
Jeng
Michael
M
Zehnder
James L
JL
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D006801:Humans; D007223:Infant; D008875:Middle Aged; D005810:Multigene Family / Q000276:immunology; D020411:Oligonucleotide Array Sequence Analysis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D051199:Toll-Like Receptor 7 / Q000235:genetics
C495348:TLR7 protein, human; D051199:Toll-Like Receptor 7