From vanilla to 28 flavors: multiple varieties of T regulatory cells.
Numerous T cell subpopulations have now been claimed to exhibit regulatory activity. Shevach discusses the current understanding of the different subsets of T regulatory cells and provides a perspective on the current areas of uncertainly and controversy in the field.
Shevach
Ethan M
EM
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. eshevach@niaid.nih.gov
D000220:Adaptation, Biological / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002469:Cell Separation; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis; D050378:T-Lymphocytes, Regulatory / Q000145:classification* / Q000276:immunology* / Q000378:metabolism
D000941:Antigens; D051858:Forkhead Transcription Factors; D016753:Interleukin-10