title: Think outside the box: extrapulmonary manifestations of severe respiratory syncytial virus infection.
abstract: Extrapulmonary effects of severe respiratory syncytial virus (RSV) infection are not uncommon. Dr Eisenhut's systematic review of extrapulmonary manifestations of severe RSV infection clearly demonstrates clinical consequences peripheral to the lung parenchyma. The extrapulmonary impact of RSV infection raises questions as to whether these are direct RSV effects (i.e., RSV infection of site-specific tissue), secondary to parenchymal lung disease and its causative respiratory failure, or the result of inflammatory mediators dispersed from the provoked respiratory epithelium.
authors.affiliation: Department of Paediatric Intensive Care, Royal Liverpool Children's Hospital, Liverpool, UK. Kent.Thorburn@rlc.nhs.uk
authors.forename: Kentigern
authors.initials: K
authors.lastname: Thorburn
authors.forename: C Anthony
authors.initials: CA
authors.lastname: Hart
mesh_terms: D000818:Animals; D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects