title: Impact of swallowing therapy on aspiration rate following treatment for locally advanced head and neck cancer.
abstract: This study examines the efficacy of swallowing therapy in cancer-free patients who developed aspiration following treatment for locally advanced head and neck cancer. The records of 41 patients who underwent swallowing therapy for aspiration were reviewed. All patients were cancer free at a median follow-up of 25 months (6-150 months). Their treatment were respectively chemoradiation (24), and postoperative radiation (17). All patients had two or more modified barium swallow (MBS). Dysphagia severity was graded from 1 to 7. Dysphagia grade was compared before and following swallowing therapy. Before swallowing therapy, there were 16 grade 5 (trace aspiration), and 25 grade 6-7 (severe aspiration). In the chemoradiation group, there were nine grade 5, five grade 6, and 10 grade 7. Corresponding numbers for the postoperative group were: seven grade 5, seven grade 6, and three grade 7. Following swallowing therapy, there were six grade 3, seven grade 4, 10 grade 5, six grade 6, and 12 grade 7. In the chemoradiation group, there were four grade 3, three grade 4, four grade 5, five grade 6, and eight grade 7. In the postoperative group, there were two grade 3, four grade 4, six grade 5, one grade 6, and four grade 7. Overall, 13 patients (32%) had improvement of their dysphagia severity. Seven of them were in the chemoradiation group (29%), and six (35%) were in the postoperative group. Among 25 patients who presented with grade 6-7 aspiration, only nine (36%) improved to grade 5 or less. Four of them (27%) were in the chemoradiation group, and five (29%) were in the postoperative group. Swallowing therapy is effective to improve dysphagia severity and reduce the need for tube feedings. However, a significant number of patients still suffered from chronic severe aspiration. New strategies must be devised to improve their outcome.
authors.affiliation: Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA. NamPhong.Nguyen@yahoo.com <NamPhong.Nguyen@yahoo.com>
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Candace C
authors.initials: CC
authors.lastname: Moltz
authors.forename: Cheryl
authors.initials: C
authors.lastname: Frank
authors.forename: Paul
authors.initials: P
authors.lastname: Vos
authors.forename: Herbert J
authors.initials: HJ
authors.lastname: Smith
authors.forename: Phuc D
authors.initials: PD
authors.lastname: Nguyen
authors.forename: Ly M
authors.initials: LM
authors.lastname: Nguyen
authors.forename: Suresh
authors.initials: S
authors.lastname: Dutta
authors.forename: Claire
authors.initials: C
authors.lastname: Lemanski
authors.forename: Sabah
authors.initials: S
authors.lastname: Sallah
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001465:Barium Radioisotopes; D003131:Combined Modality Therapy / Q000009:adverse effects; D003679:Deglutition; D003680:Deglutition Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D005471:Fluoroscopy; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011015:Pneumonia, Aspiration / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D001465:Barium Radioisotopes