title: N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.
abstract: A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to >200-fold.
authors.affiliation: GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Nie
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Widdowson
authors.forename: Michael R
authors.initials: MR
authors.lastname: Palovich
authors.forename: Wei
authors.initials: W
authors.lastname: Fu
authors.forename: John D
authors.initials: JD
authors.lastname: Elliott
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Bryan
authors.forename: Miriam
authors.initials: M
authors.lastname: Burman
authors.forename: Dulcie B
authors.initials: DB
authors.lastname: Schmidt
authors.forename: James J
authors.initials: JJ
authors.lastname: Foley
authors.forename: Henry M
authors.initials: HM
authors.lastname: Sarau
authors.forename: Jakob
authors.initials: J
authors.lastname: Busch-Petersen
mesh_terms: D006146:Guanidines / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D023062:Receptors, Interleukin-8A / Q000037:antagonists & inhibitors*; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors*
chemical_list: D006146:Guanidines; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B; C004711:dicyandiamido