Adiponectin added into the plasma of healthy probands does not affect platelet aggregability.
Six healthy non-obese probands without medical therapy and history of disease were tested. In all of them platelet aggregability with addition of human recombinant adiponectin in different concentrations (100; 75; 50 and 25 ng/l) were measured. It is concluded that increased level of adiponectin has no significant antiaggregation effect on platelets from individuals without hypoadiponectinemia.
Stejskal
David
D
Department of Laboratory Medicine, Sternberk Hospital, Czech Republic. david.stejskal@quick.cz
Proskova
Jitka
J
Solichova
Pavlina
P
D052242:Adiponectin / Q000494:pharmacology; D000328:Adult; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology
C499918:ADIPOQ protein, human; D052242:Adiponectin; D011994:Recombinant Proteins