title: Course of vasopressin and copeptin plasma concentrations in a patient with severe septic shock.
abstract: In this case report, the course of arginine vasopressin and copeptin, the stable C-terminal part of the arginine vasopressin precursor, is described during the period of critical illness in a septic shock patient. Arginine vasopressin and copeptin concentrations were substantially increased during the initial 36 hours of shock. Subsequently, both hormones continuously decreased, but exhibited another peak in response to stress during extubation. During restoration of cardiovascular stability, endogenous arginine vasopressin levels further decreased and obviously did not contribute to haemodynamic improvement. In contrast, the decrease in arginine vasopressin and copeptin can be at least partly explained by an improvement of cardiovascular function.
authors.affiliation: Department of Anesthesiology, Innsbruck Medical University, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Jochberger
authors.forename: G
authors.initials: G
authors.lastname: Luckner
authors.forename: V D
authors.initials: VD
authors.lastname: Mayr
authors.forename: V
authors.initials: V
authors.lastname: Wenzel
authors.forename: N G
authors.initials: NG
authors.lastname: Morgenthaler
authors.forename: B E
authors.initials: BE
authors.lastname: Friesenecker
authors.forename: W R
authors.initials: WR
authors.lastname: Hasibeder
authors.forename: M W
authors.initials: MW
authors.lastname: Dünser
mesh_terms: D001127:Arginine Vasopressin / Q000097:blood*; D002908:Chronic Disease; D003422:Critical Care; D006020:Glycopeptides / Q000097:blood*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D007416:Intestinal Perforation / Q000150:complications; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000150:complications; D012772:Shock, Septic / Q000097:blood* / Q000209:etiology / Q000382:microbiology; D013290:Streptococcal Infections / Q000097:blood / Q000209:etiology / Q000382:microbiology; D034364:Streptococcus milleri Group
chemical_list: D006020:Glycopeptides; C048197:copeptins; D001127:Arginine Vasopressin