title: Total synthesis of agelagalastatin.
abstract: The total synthesis of agelagalastatin, an antineoplastic glycosphingolipid, has been achieved. The synthesis involved an alpha-selective glycosylation of the ceramide moiety with the trisaccharide fluoride. The trisaccharide component was constructed employing the CB glycoside method which permitted a completely alpha-stereoselective galactofuranosylation.
authors.affiliation: Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
authors.forename: Yong Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Bo-Young
authors.initials: BY
authors.lastname: Lee
authors.forename: Heung Bae
authors.initials: HB
authors.lastname: Jeon
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Kim
mesh_terms: D047230:Agelas / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D020383:Neutral Glycosphingolipids / Q000138:chemical synthesis*
chemical_list: D000970:Antineoplastic Agents; D020383:Neutral Glycosphingolipids; C520907:agelagalastatin