title: Phenolic constituents of the roots of Sophora flavescens.
abstract: From the roots of Sophora flavescens collected in Taiwan, four new prenylflavonoids, sophoraflavanone K (1), sophoraflavanone L (2), 8-lavandulylkaempferol (3), and cyclokuraridin (4), a new arylbenzofuran, 2-(2,4-dihydroxy-5-prenylphenyl)-5,6-methylenedioxybenzofuran (5), and a new prenyldibenzoyl derivative, sophoradione (6), were isolated. The structures of 1-6 were determined by spectroscopic data analysis. Compounds 2-6 were evaluated for cytotoxic activity against the KB epidermoid carcinoma cell line.
authors.affiliation: National Research Institute of Chinese Medicine, No. 155-1, Sec. 2, Li Nung Street, Peitou, Taipei, Taiwan, Republic of China.
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.forename: Ting-Wei
authors.initials: TW
authors.lastname: Lin
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Huang
authors.forename: Shr-Ting
authors.initials: ST
authors.lastname: Wan
authors.forename: Bor-Jinn
authors.initials: BJ
authors.lastname: Shien
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
mesh_terms: D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029909:Sophora / Q000737:chemistry*; D013624:Taiwan
chemical_list: D010636:Phenols