title: The venous system is the main determinant of hypotension in patients with vasovagal syncope.
abstract: OBJECTIVE
  In patients with vasovagal syncope (VVS), a neural reflex appears the main determinant of hypotension leading to loss of consciousness; whether hypotension is mainly due to involvement of the arterial system or the venous system remains a debated issue. The aim of the present study was to assess which of these two systems is responsible for the fall in blood pressure (BP) in patients with VVS; to this end, a haemodynamic study was carried out not only before and during loss of consciousness but also during the recovery phase.
  
  
  RESULTS
  Beat-to-beat recordings of heart rate (HR), BP (volume-clamp method) and stroke volume (SV) (modelflow method), cardiac output (CO), and total peripheral resistance (TPR) were made at rest, during unmedicated tilt testing (TT) and recovery from loss of consciousness in 18 patients with a history of syncope (age 45+/-23 years) and positive response to TT. Blood pressure showed a significant fall during prodromal symptoms and a further fall at the beginning of loss of consciousness, together with a fall in SV, CO, and HR, and a slight, but significant, increase in TPR. At the beginning of recovery, BP showed a significant increase and a further increase 5 min later, together with an increase in SV, CO, and HR without significant changes in TPR.
  
  
  CONCLUSIONS
  These results suggest that in VVS the fall in BP is mainly caused by reduced venous return to the heart. The arterial system does not appear to be the main determinant of the fall of BP; however, the system appears unable to make the appropriate compensatory changes.
authors.affiliation: Division of Cardiology, Ospedale Civile, 44042 Cento (Fe), Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Fucà
authors.forename: Maurizio
authors.initials: M
authors.lastname: Dinelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Suzzani
authors.forename: Salvatore
authors.initials: S
authors.lastname: Scarfò
authors.forename: Fabio
authors.initials: F
authors.lastname: Tassinari
authors.forename: Paolo
authors.initials: P
authors.lastname: Alboni
mesh_terms: D001794:Blood Pressure; D002302:Cardiac Output; D005260:Female; D006339:Heart Rate; D006801:Humans; D007022:Hypotension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D019462:Syncope, Vasovagal / Q000150:complications*; D018667:Tilt-Table Test; D014655:Vascular Resistance; D014680:Veins / Q000503:physiopathology*