title: Chronic craniofacial dematiaceous fungal infection: a case report.
abstract: Curvularia is a saprobic dematiaceous mold that has been associated with a wide spectrum of human infection. In non-immunosuppressed patients, infections frequently involve the paranasal sinus, skin, and soft tissue, whereas systemic dissemination and endocarditis are extremely rare. The optimal antifungal therapy for Curvularia infection is not known, and responses to treatment with amphotericin B, miconazole, ketoconazole, terbinafine, and itraconazole have been reported. We describe a patient with an invasive dematiaceous fungal sinusitis who was immunocompetent and was infected with Curvularia. The patient was successfully treated with oral itraconazole by otolaryngology and the infectious disease service.
authors.affiliation: Medically Complex Patient Clinic, Department of Restorative Dentistry, The University of Texas Dental Branch at Houston, USA. kishore.shetty@uth.tmc.edu
authors.forename: Kishore
authors.initials: K
authors.lastname: Shetty
authors.forename: Peter
authors.initials: P
authors.lastname: Giannini
authors.forename: Ronald
authors.initials: R
authors.lastname: Achong
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003646:Debridement; D003881:Dermatomycoses / Q000175:diagnosis*; D005148:Facial Dermatoses / Q000382:microbiology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D015523:Maxillary Sinusitis / Q000382:microbiology; D008875:Middle Aged; D003904:Mitosporic Fungi / Q000302:isolation & purification*; D021362:Palate, Hard / Q000382:microbiology; D012883:Skin Ulcer / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole