title: Potent benzimidazolone based human beta(3)-adrenergic receptor agonists.
abstract: The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
authors.forename: Don R
authors.initials: DR
authors.lastname: Finley
authors.forename: Michael G
authors.initials: MG
authors.lastname: Bell
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Borel
authors.forename: William E
authors.initials: WE
authors.lastname: Bloomquist
authors.forename: Marlene L
authors.initials: ML
authors.lastname: Cohen
authors.forename: Mark L
authors.initials: ML
authors.lastname: Heiman
authors.forename: Aidas
authors.initials: A
authors.lastname: Kriauciunas
authors.forename: Donald P
authors.initials: DP
authors.lastname: Matthews
authors.forename: Tania
authors.initials: T
authors.lastname: Miles
authors.forename: David A
authors.initials: DA
authors.lastname: Neel
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Rito
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sall
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Shuker
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Stephens
authors.forename: Frank C
authors.initials: FC
authors.lastname: Tinsley
authors.forename: Mark A
authors.initials: MA
authors.lastname: Winter
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Jesudason
mesh_terms: D058673:Adrenergic beta-3 Receptor Antagonists; D000318:Adrenergic beta-Agonists / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans
chemical_list: D058673:Adrenergic beta-3 Receptor Antagonists; D000318:Adrenergic beta-Agonists; D001562:Benzimidazoles; C014353:benzimidazolone