The role of inferior parietal and inferior frontal cortex in working memory.
Verbal working memory involves two major components: a phonological store that holds auditory-verbal information very briefly and an articulatory rehearsal process that allows that information to be refreshed and thus held longer in short-term memory (A. Baddeley, 1996, 2000; A. Baddeley & G. Hitch, 1974). In the current study, the authors tested two groups of patients who were chosen on the basis of their relatively focal lesions in the inferior parietal (IP) cortex or inferior frontal (IF) cortex. Patients were tested on a series of tasks that have been previously shown to tap phonological storage (span, auditory rhyming, and repetition) and articulatory rehearsal (visual rhyming and a 2-back task). As predicted, IP patients were disproportionately impaired on the span, rhyming, and repetition tasks and thus demonstrated a phonological storage deficit. IF patients, however, did not show impairment on these storage tasks but did exhibit impairment on the visual rhyming task, which requires articulatory rehearsal. These findings lend further support to the working memory model and provide evidence of the roles of IP and IF cortex in separable working memory processes.
Baldo
Juliana V
JV
Center for Aphasia and Related Disorders, Veterans Affairs Northern California Health Care System, Martinez, CA 94553, USA. juliana@ebire.org
Dronkers
Nina F
NF
D000328:Adult; D000368:Aged; D001037:Aphasia / Q000523:psychology; D004493:Education; D005260:Female; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology* / Q000503:physiopathology*; D011932:Reading; D020521:Stroke / Q000473:pathology* / Q000523:psychology*; D014706:Verbal Learning / Q000502:physiology