title: Quantitative magnetoencephalography of spontaneous brain activity in Alzheimer disease: an exhaustive frequency analysis.
abstract: Quantitative magnetoencephalography (qMEG) was used to investigate differences in the 2 to 60 Hz spectral power, between Alzheimer disease (AD) patients and control subjects. Twenty-two AD patients and 21 age-matched control subjects participated in this study. MEG signal analysis comprised the division of the entire 2 to 60 Hz spectrum in 2 Hz-width subbands. Both the relative power and the contribution of each subband to the correct classification of AD patients and controls were calculated. The relative power in 2 bands comprised between 2 to 4 Hz and 16 to 28 Hz was selected by a restrictive multiple-comparison test, among the entire 2 to 60 Hz spectrum. Using 2 to 4 Hz values it is possible to choose a classification rule with an estimate sensitivity and specificity given by 68% and 76% respectively. Alternatively, when 16 to 28 Hz values are used, it is possible to obtain a better classification rule with an estimate sensitivity and specificity given by 81% and 80%, respectively. To the best of our knowledge, this is the first electroencephalography or MEG study where a so exhaustive analysis of the magneto-electric spectrum has been performed. This study supports the notion that more attention should be devoted to the study of beta band in AD.
authors.affiliation: Centro de Magnetoencefalografía Dr Pérez-Modrego, Universidad Complutense de Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández
authors.forename: Roberto
authors.initials: R
authors.lastname: Hornero
authors.forename: Agustín
authors.initials: A
authors.lastname: Mayo
authors.forename: Jesús
authors.initials: J
authors.lastname: Poza
authors.forename: Fernando
authors.initials: F
authors.lastname: Maestú
authors.forename: Tomás
authors.initials: T
authors.lastname: Ortiz Alonso
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D001611:Beta Rhythm; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D012680:Sensitivity and Specificity