Scale-invariant structure of strongly conserved sequence in genomic intersections and alignments.
A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional noncoding sequence and ought to be accounted for in estimating the statistical significance of apparent sequence conservation. These inter-genomic correlations of conservation are placed in the context of previously observed intra-genomic correlations, and their possible origins and consequences are discussed.
Salerno
William
W
Department of Biochemistry and Molecular Biology and Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Havlak
Paul
P
Miller
Jonathan
J
D000818:Animals; D001483:Base Sequence; D016000:Cluster Analysis; D017124:Conserved Sequence / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D023281:Genomics; D006801:Humans; D051379:Mice; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D016415:Sequence Alignment