title: [MR perfusion and spectroscopic imaging in WHO grade II astrocytomas].
abstract: BACKGROUND
  This study evaluates whether MR perfusion imaging and spectroscopic imaging (MRSI) can depict anaplastic areas in WHO grade II astrocytomas, whether these areas are co-localized, and whether the prognosis can be better predicted.
  
  
  METHODS
  Fifteen patients (nine female, six male, aged 42+/-14 years) with WHO grade II astrocytomas but without preceding radio- or chemotherapy were examined every 3 months with MR perfusion imaging and MRSI (mean follow-up 18 months). Using a region of interest analysis, the regional relative cerebral blood volume (rrCBV) and blood flow (rrCBF) were measured in tumor tissue. In the same areas, choline/creatine (Cho/Cr) and choline/N-acetyl-aspartate (Cho/NAA) ratios were quantified.
  
  
  RESULTS
  During follow-up, nine patients had stable disease. In six patients, the tumor showed progression and contrast-enhancement. The progressing tumors had already had higher perfusion (rrCBF 2.1+/-1.4; rrCBV 1.9+/-1.1) parameters than the stable astrocytomas (rrCBF 1.2+/-0.6, p=0.01; rrCBV 1.4+/-0.8, p=0.05) at first examination. However, the Cho/NAA and Cho/Cr ratios only tended to be higher than in stable astrocytomas (Cho/NAA 2.4+/-1.0 vs. 2.0+/-1.5, p=0.23; Cho/Cr 1.7+/-0.6 vs. 1.4+/-0.5, p=0.06). In all six progressing tumors, areas of maximum perfusion and maximum Cho/NAA and Cho/Cr ratio were co-localized. During follow-up, contrast-enhancement was observed in these areas.
  
  
  CONCLUSIONS
  MR perfusion imaging can depict anaplastic areas in WHO grade II astrocytomas earlier than conventional MRI and thus enables a better prediction of prognosis.
authors.affiliation: Abteilung Radiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg. m.a.weber@dkfz.de
authors.forename: M-A
authors.initials: MA
authors.lastname: Weber
authors.forename: M
authors.initials: M
authors.lastname: Vogt-Schaden
authors.forename: O
authors.initials: O
authors.lastname: Bossert
authors.forename: F L
authors.initials: FL
authors.lastname: Giesel
authors.forename: H-U
authors.initials: HU
authors.lastname: Kauczor
authors.forename: M
authors.initials: M
authors.lastname: Essig
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003627:Data Interpretation, Statistical; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors; D014944:World Health Organization