title: Penicillin resistance and serotyping of Streptococcus pneumoniae in Latin America.
abstract: Streptococcus pneumoniae (Strep. pneumoniae) is the main cause of bacterial pneumonia in children less than 5 years of age, with high mortality rates in developing countries. In 1993, the Regional System for Vaccines Group (SIREVA) of the pan-American Health Organisation (PAHO) began a study involving six Latin American countries to identify serotypes and their representativity in the new conjugated vaccines, and to determine the degree of resistance to penicillin. Serotypes 14 (highest resistance level), 5, 1, 6A/B, 23F, 7F, 9V, 19F, 18C, 19A, 9N, were prevalent in the region, with some differences among countries. Although resistance to penicillin ranged from 2% (Brazil) to 21.1% (Mexico), studies have shown that pneumonia caused by Strep. pneumoniae with diminished sensitivity to penillin can be treated with this antibiotic. Only 58% of the serotypes isolated in the region studied were represented in the seven-valent vaccine. Continual surveillance is essential to determine which formulation of conjugated vaccine will be suitable for use in Latin America.
authors.affiliation: Department of Paediatrics, Medical School, Federal University of Minas Geraias, Avenida Alfredo Balena, 190/Room 4061, 30130-100 Belo Horizonte, and Respiratory Department, Hospital da Criança Santo Antonio, Porto Alegre, Brazil. pcamargs@medicina.ufmg.br
authors.forename: Paulo
authors.initials: P
authors.lastname: Camargos
authors.forename: Gilberto Bueno
authors.initials: GB
authors.lastname: Fischer
authors.forename: Helena
authors.initials: H
authors.lastname: Mocelin
authors.forename: Cícero
authors.initials: C
authors.lastname: Dias
authors.forename: Raúl
authors.initials: R
authors.lastname: Ruvinsky
mesh_terms: D000293:Adolescent; D002648:Child; D004352:Drug Resistance, Microbial; D006801:Humans; D007843:Latin America; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D022242:Pneumococcal Vaccines / Q000627:therapeutic use; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000378:metabolism*
chemical_list: D010406:Penicillins; D022242:Pneumococcal Vaccines