title: Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.
abstract: Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2rgamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2rgamma(-/-)Rag2(-/-) LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR(+) T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.
authors.affiliation: Division of Molecular Immunology and Immune Cell Biology and Confocal Microscopy and Image Analysis Laboratory, National Institute for Medical Research, Mill Hill, London, United Kingdom. m542@york.ac.uk
authors.forename: Mark C
authors.initials: MC
authors.lastname: Coles
authors.forename: Henrique
authors.initials: H
authors.lastname: Veiga-Fernandes
authors.forename: Katie E
authors.initials: KE
authors.lastname: Foster
authors.forename: Trisha
authors.initials: T
authors.lastname: Norton
authors.forename: Stamatis N
authors.initials: SN
authors.lastname: Pagakis
authors.forename: Ben
authors.initials: B
authors.lastname: Seddon
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kioussis
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000831:Animals, Newborn; D018076:DNA, Complementary; D049452:Green Fluorescent Proteins / Q000378:metabolism; D015851:Interleukin-7 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008198:Lymph Nodes / Q000196:embryology / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D008954:Models, Biological; D009154:Mutation; D016328:NF-kappa B / Q000235:genetics; D020395:Receptors, Interleukin-7 / Q000235:genetics* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D019076:Transgenes
chemical_list: D018076:DNA, Complementary; D015851:Interleukin-7; D016328:NF-kappa B; D020395:Receptors, Interleukin-7; D049452:Green Fluorescent Proteins