[Procedural learning and anxiolytic effects: electroencephalographic, motor and attentional measures].
The objective of the present study was to evaluate attentional, motor and electroencephalographic (EEG) parameters during a procedural task when subjects have ingested 6 mg of bromazepam. The sample consisted of 26 healthy subjects, male or female, between 19 and 36 years of age. The control (placebo) and experimental (bromazepam 6 mg) groups were submitted to a typewriting task in a randomized, double-blind design. The findings did not show significant differences in attentional and motor measures between groups. Coherence measures (qEEG) were evaluated between scalp regions, in theta, alpha and beta bands. A first analysis revealed a main effect for condition (Anova 2-way--condition versus blocks). A second Anova 2-way (condition versus scalp regions) showed a main effect for both factors. The coherence measure was not a sensitive tool at demonstrating differences between cortical areas as a function of procedural learning.
Portella
Claudio Elidio
CE
Laboratório de Mapeamento Cerebral e Integração Sensório-motor, IPUB, Universidade Federal do Rio de Janeiro, Rua Filgueiras Lima 68/104, 20950-050 Rio de Janeiro RJ, Brazil.
Silva
Julio Guilherme
JG
Bastos
Victor Hugo
VH
Machado
Dionis
D
Cunha
Marlo
M
Cagy
Maurício
M
Basile
Luis
L
Piedade
Roberto
R
Ribeiro
Pedro
P
D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects*; D001931:Brain Mapping; D001960:Bromazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D009048:Motor Skills / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D001960:Bromazepam