Intestinal mucosal adaptation.
Intestinal failure is a condition characterized by malnutrition and/or dehydration as a result of the inadequate digestion and absorption of nutrients. The most common cause of intestinal failure is short bowel syndrome, which occurs when the functional gut mass is reduced below the level necessary for adequate nutrient and water absorption. This condition may be congenital, or may be acquired as a result of a massive resection of the small bowel. Following resection, the intestine is capable of adaptation in response to enteral nutrients as well as other trophic stimuli. Identifying factors that may enhance the process of intestinal adaptation is an exciting area of research with important potential clinical applications.
Drozdowski
Laurie
L
University of Alberta, Edmonton AB, T6G 2N8, Canada. lad2@ualberta.ca
Thomson
Alan B R
AB
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D004195:Disease Models, Animal; D005247:Feeding Behavior / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000503:physiopathology*; D051381:Rats; D012778:Short Bowel Syndrome / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D015398:Signal Transduction / Q000502:physiology; D013552:Swine
D005768:Gastrointestinal Hormones