title: Noxious compounds in exhaled air, a potential cause for ocular manifestations of H. pylori gastrointestinal infection.
abstract: Helicobacter pylori infection is one of the most common chronic bacterial infections worldwide. In the past few years, a variety of extradigestive disorders have been associated with H. pylori infection. This infection has also been linked to some ophthalmic disorders, including glaucoma, central serous chorioretinopathy, uveitis and blepharitis. Several possible theories to explain pathogenetic mechanism underlying the observed associations have been provided. H. pylori infection causes elaboration of some noxious compounds, including ammonia, hydrogen nitrate and hydrogen cyanide, in exhaled breath of infected individuals. Herein we hypothesize that chronic exposure of ocular surface to these compounds may explain some ophthalmic and also respiratory manifestations of the chronic gastrointestinal infection.
authors.affiliation: Shiraz University of Medical Sciences, Ophthalmology department, Khalili Hospital, Shiraz, Iran. hosseini.hamid@gmail.com
authors.forename: Hamid
authors.initials: H
authors.lastname: Hosseini
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghaffariyeh
authors.forename: Reza
authors.initials: R
authors.lastname: Nikandish
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D045853:Exhalation; D005123:Eye / Q000187:drug effects / Q000382:microbiology; D005128:Eye Diseases / Q000139:chemically induced* / Q000382:microbiology*; D005759:Gastroenteritis / Q000150:complications*; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology*; D016480:Helicobacter pylori; D006801:Humans
chemical_list: D000393:Air Pollutants