N-acetyllactosamine conjugated to gold nanoparticles inhibits enteropathogenic Escherichia coli colonization of the epithelium in human intestinal biopsy specimens.
We previously reported that the bundle-forming pilus-mediated localized adherence of enteropathogenic Escherichia coli to HEp-2, T84, and Caco-2 cells is inhibited by N-acetyllactosamine neoglycoconjugates. The results presented here extend this observation to the epithelium of biopsy specimens obtained from the human adult duodenum, terminal ileum, and colon.
Hyland
Romney M
RM
Department of Microbiology & Infectious Diseases, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
Beck
Paul
P
Mulvey
George L
GL
Kitov
Pavel I
PI
Armstrong
Glen D
GD
D000328:Adult; D000368:Aged; D000606:Amino Sugars / Q000737:chemistry / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D004926:Escherichia coli / Q000187:drug effects* / Q000472:pathogenicity; D005260:Female; D006046:Gold / Q000737:chemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology* / Q000473:pathology; D007422:Intestines / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D049329:Nanostructures / Q000737:chemistry
D000606:Amino Sugars; C000458:N-acetyllactosamine; D006046:Gold