Interferon: the pathways of discovery I. Molecular and cellular aspects.
This historical account covers 50 years of seminal research work on interferon done since its discovery in 1957. Topics related to molecular structure, production and action of interferons are considered from the viewpoint of how our insights have expanded and deepened within the context of evolving tools and general knowledge in cellular and molecular biology. Lines of thought that linked each discovery to the next are expounded.
Billiau
Alfons
A
Rega Institute, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium. Alfons.Billiau@Rega.Kuleuven.be
D000818:Animals; D016207:Cytokines / Q000266:history / Q000502:physiology; D049673:History, 20th Century; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000266:history*; D017471:Receptors, Interferon / Q000266:history / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D016207:Cytokines; D017471:Receptors, Interferon; D007372:Interferons