title: The relation of amino-terminal propeptide of type III procollagen and severity of coronary artery disease in patients without myocardial infarction or hibernation.
abstract: OBJECTIVE
  The association of cardiac fibrosis and coronary artery disease (CAD) in patients without infarction or hibernation is unclear. We investigated the relationship between serum concentrations of procollagen propeptides and severity of CAD in such patients.
  
  
  METHODS
  Forty-six patients (32 men; mean age 64 years) with chest pain were enrolled. All patients received stress thallium-201 single photon emission computed tomography (SPECT) and analysis of the serum levels of the amino-terminal propeptide of type I and III procollagen (PINP and PIIINP).
  
  
  RESULTS
  In patients with thallium-201 perfusion defects, the number of diseased vessels was associated significantly with PIIINP (p=0.024) rather than PINP (p=0.613). Follow-up serum PINP and PIIINP levels after coronary intervention (mean 84 days) revealed no significant decrease.
  
  
  CONCLUSIONS
  Serum PIIINP level is significantly associated with the severity of CAD in patients without myocardial infarction or hibernation.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
authors.forename: Yen-Hung
authors.initials: YH
authors.lastname: Lin
authors.forename: Yi-Lwun
authors.initials: YL
authors.lastname: Ho
authors.forename: Tzung-Dau
authors.initials: TD
authors.lastname: Wang
authors.forename: Chung-Pin
authors.initials: CP
authors.lastname: Liu
authors.forename: Hsien-Li
authors.initials: HL
authors.lastname: Kao
authors.forename: Chia-Lun
authors.initials: CL
authors.lastname: Chao
authors.forename: Kuo-Liong
authors.initials: KL
authors.lastname: Chien
authors.forename: Chi-Sheng
authors.initials: CS
authors.lastname: Hung
authors.forename: Vin-Cent
authors.initials: VC
authors.lastname: Wu
authors.forename: I-Jung
authors.initials: IJ
authors.lastname: Tsai
authors.forename: Ruoh-Fang
authors.initials: RF
authors.lastname: Yen
authors.forename: Yu-Chien
authors.initials: YC
authors.lastname: Shiau
authors.forename: Wen-Jone
authors.initials: WJ
authors.lastname: Chen
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D006328:Cardiac Catheterization; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D003331:Coronary Vessels / Q000737:chemistry; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D015425:Myocardial Reperfusion; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; D013794:Thallium Radioisotopes; C047202:procollagen Type I N-terminal peptide; C041876:procollagen Type III-N-terminal peptide