KIR/HLA pleiotropism: protection against both HIV and opportunistic infections.
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.
Qi
Ying
Y
Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, USA.
Martin
Maureen P
MP
Gao
Xiaojiang
X
Jacobson
Lisa
L
Goedert
James J
JJ
Buchbinder
Susan
S
Kirk
Gregory D
GD
O'Brien
Stephen J
SJ
Trowsdale
John
J
Carrington
Mary
M
D017088:AIDS-Related Opportunistic Infections / Q000235:genetics* / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology; D018450:Disease Progression; D006679:HIV Seropositivity; D015497:HIV-1; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy; D007694:Killer Cells, Natural / Q000276:immunology* / Q000821:virology; D016483:Lymphoma, AIDS-Related / Q000235:genetics / Q000276:immunology; D011971:Receptors, Immunologic / Q000235:genetics* / Q000276:immunology; D054340:Receptors, KIR; D054349:Receptors, KIR3DS1; D012514:Sarcoma, Kaposi / Q000235:genetics / Q000276:immunology
D015235:HLA-B Antigens; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054349:Receptors, KIR3DS1