title: Leukocyte infiltration in cancer creates an unfavorable environment for antitumor immune responses: a novel target for therapeutic intervention.
abstract: The interaction between tumor cells and the nearby environment is being actively investigated to explore how this interplay affects the initiation and progression of cancer. Host-tumor relationship results in the production of pro-inflammatory cytokines and chemokines that promote the recruitment of leukocytes within and around developing neoplasms. Cancer cells, together with newly recruited tumor-infiltrating cells, can also activate fibroblast and vascular responses, thus resulting in a chronic microenvironment perturbation. In this complex scenario, interactions between innate and adaptive immune cells can be disturbed, leading to a failure of immune-mediated tumor recognition and destruction. On the basis of the recent awareness about tumor promotion and immune deregulation by immune/inflammatory cells, novel anti-cancer strategies can be exploited.
authors.affiliation: Istituto Oncologico Veneto, Department of Oncology and Surgical Sciences, Oncology Section, Padua University, Padua, Italy. enzo.bronte@unipd.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bronte
authors.forename: Sara
authors.initials: S
authors.lastname: Cingarlini
authors.forename: Ilaria
authors.initials: I
authors.lastname: Marigo
authors.forename: Carmela
authors.initials: C
authors.lastname: De Santo
authors.forename: Giovanna
authors.initials: G
authors.lastname: Gallina
authors.forename: Luigi
authors.initials: L
authors.lastname: Dolcetti
authors.forename: Stefano
authors.initials: S
authors.lastname: Ugel
authors.forename: Elisa
authors.initials: E
authors.lastname: Peranzoni
authors.forename: Susanna
authors.initials: S
authors.lastname: Mandruzzato
authors.forename: Paola
authors.initials: P
authors.lastname: Zanovello
mesh_terms: D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007249:Inflammation / Q000276:immunology; D007962:Leukocytes / Q000166:cytology / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism*
chemical_list: D016207:Cytokines