title: Unified total syntheses of the inositol polyphosphates: D-I-3,5,6P3, D-I-3,4,5P3, D-I-3,4,6P3, and D-I-3,4,5,6P4 via catalytic enantioselective and site-selective phosphorylation.
abstract: Synthetic routes to various inositol polyphosphates have been discovered utilizing catalytic enantioselective and site-selective phosphorylation reactions. The syntheses described herein exploit a common intermediate to gain efficient access to eight unique inositol polyphosphates.
authors.affiliation: Department of Chemistry, Boston College, Chestnut Hill, MA 02467, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Morgan
authors.forename: Shio
authors.initials: S
authors.lastname: Komiya
authors.forename: Yingju
authors.initials: Y
authors.lastname: Xu
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Miller
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D007295:Inositol Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D010766:Phosphorylation; D011122:Polyphosphates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007295:Inositol Phosphates; D011122:Polyphosphates; C118500:inositol 3,4,5-trisphosphate; C081652:inositol-3,4,5,6-tetrakisphosphate