title: Selective synthesis of functionalized thia- and oxacalix[2]arene[2]pyrimidines.
abstract: Functionalized oxacalix[m]arene[n]pyrimidines have been synthesized by S(N)Ar on 4,6-dihalopyrimidine building blocks. Depending on the S(N)Ar conditions, either a mixture of oxacalix[n]arenes, ranging from oxacalix[4]- up to oxacalix[12]arene, could be prepared or the oxacalix[4]arene could be synthesized selectively in a high yield. The electrophilic (pyrimidine) and the nucleophilic components could both be varied, allowing the preparation of functionalized oxacalix[4]arenes. Moreover, the procedure also gives access to the analogous thiacalix[4]arenes.
authors.affiliation: Molecular Design and Synthesis and Biomolecular Architecture, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Wouter
authors.initials: W
authors.lastname: Maes
authors.forename: Wim
authors.initials: W
authors.lastname: Van Rossom
authors.forename: Kristof
authors.initials: K
authors.lastname: Van Hecke
authors.forename: Luc
authors.initials: L
authors.lastname: Van Meervelt
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen