Pathways to the discovery of the Abeta amyloid of Alzheimer's disease.
Many participants played a role in discovering the composition and sequence of the Abeta amyloid of Alzheimer's disease. This sequence enabled the cloning of the amyloid precursor protein (APP), which elucidated its proteolytic origin from the membrane of neurons. The proteolytic enzymes which process APP and the Abeta fragment itself are now the prime validated drug targets for therapeutic intervention.
Masters
Colin L
CL
Department of Pathology, The University of Melbourne, and the Mental Health Research Institute of Victoria, Australia. c.masters@unimelb.edu.au
Beyreuther
Konrad
K
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D002845:Chromatography / Q000295:instrumentation; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism / Q000473:pathology; D006801:Humans; D010447:Peptide Hydrolases / Q000502:physiology
D016564:Amyloid beta-Protein Precursor; D010447:Peptide Hydrolases