Human hepatocyte transplantation: worldwide results.
The conception and animal modeling of hepatocyte transplantation along with a partial listing of human hepatocyte infusions over the last 13 years have been detailed in authoritative reviews. However, to adequately best represent the worldwide effort of moving from highly successful clinical solid liver transplants "back to" isolated hepatocyte therapy requires repeating important concepts with explanations of how or why not animal experimental data translate to human experience. This overview summarizes 78 human clinical hepatocyte transplant experiences authenticated by the authors. The human cell infusion experiences are categorized by liver disease treated (metabolic, chronic, and acute liver failure), and these are accompanied by seminal in vitro and in vivo experimental data.
Fisher
Robert A
RA
Department of Surgery, Transplantation Division, Virginia Commonwealth University, Medical College of Virginia Hospitals, Richmond, VA, USA. rafisher@vcu.edu
Strom
Stephen C
SC
D002469:Cell Separation; D002908:Chronic Disease; D022781:Hepatocytes / Q000637:transplantation*; D006801:Humans; D008107:Liver Diseases / Q000601:surgery; D017114:Liver Failure, Acute / Q000601:surgery; D014015:Tissue Banks