title: Solitary mandibular metastasis as an initial manifestation of hepatocellular carcinoma.
abstract: Oral metastases from hepatocellular carcinoma are very rare. We encountered a case of hepatocellular carcinoma with a solitary metastasis to the mandible as an initial manifestation. The patient was a 76-year-old man who was admitted for left mandibular swelling. A biopsy specimen of mandible was suspected to be a metastatic tumor. The histological findings, abdominal computed tomography, bone scintigraphy, and F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed it to be a solitary metastasis from hepatocellular carcinoma. As a result, he was diagnosed to have liver cirrhosis due to a hepatitis C virus infection and hepatocellular carcinoma with a solitary metastasis to the mandible. The primary lesion was treated with transcatheter arterial embolization (TAE), and the metastasis to the mandible was surgically resected. The patient survived for 9 months after treatment without recurrence.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Teshigawara
authors.forename: Satoru
authors.initials: S
authors.lastname: Kakizaki
authors.forename: Naondo
authors.initials: N
authors.lastname: Sohara
authors.forename: Tetsu
authors.initials: T
authors.lastname: Hashida
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tomizawa
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takagi
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
authors.forename: Keiko
authors.initials: K
authors.lastname: Hoshino
authors.forename: Kenji
authors.initials: K
authors.lastname: Mogi
mesh_terms: D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008339:Mandibular Neoplasms / Q000473:pathology / Q000556:secondary*