title: In vitro interactions of captopril with NSAID's.
abstract: Captopril is effective in the treatment of hypertension of all grades of severity. Present paper deals with the in vitro availability studies of captopril in presence and absence of commonly used NSAID's likes diclofenac sodium, flurbiprofen, mefenamic acid, meloxicam and tiaprofenic acid. Since it had been established that simultaneous administration of both drugs may alter the antihypertensive effect of captopril. In order to find out the kinetics and energitics of captopril in presence of NSAID's, these studies were carried out in buffers of pH 4, 7.4 and 9 at 37 degrees C and at elevated temperatures. These studies clearly indicate that most of the NSAID's bind to captopril, forming charge-transfer complexes revealing that the availability of captopril can be affected by the concurrent administration of NSAID's. Accordingly coadministration of both the drugs should be avoided.
authors.affiliation: Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Najma
authors.initials: N
authors.lastname: Sultana
authors.forename: M Saeed
authors.initials: MS
authors.lastname: Arayne
authors.forename: Reeshan Ul
authors.initials: RU
authors.lastname: Quraishi
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002216:Captopril / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004344:Drug Incompatibility; D004734:Energy Metabolism / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D013816:Thermodynamics
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002216:Captopril