title: Corneal melting associated with topical diclofenac use after laser-assisted subepithelial keratectomy.
abstract: We report a case of corneal melting associated with topically applied preservative-free diclofenac (Voltaren Ofta) after laser-assisted subepithelial keratectomy. Keratolysis was detected on day 5; further progression toward perforation was arrested by immediate suspension of diclofenac and prescription of topical dexamethasone with 24-hour patching. At the last follow-up, the visual acuity had improved from counting fingers to 20/20. Preservative-free diclofenac instillation had never been associated with keratolysis. Topical steroids may be useful in treating corneal melting associated with nonsteroidal antiinflammatory drugs.
authors.affiliation: Centro Salus, Bologna, Italy. m.zanini@eyeproject.com
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zanini
authors.forename: Giacomo
authors.initials: G
authors.lastname: Savini
authors.forename: Piero
authors.initials: P
authors.lastname: Barboni
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D049008:Keratectomy, Subepithelial, Laser-Assisted; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac