title: [The role of sentinel lymph node biopsy in breast cancer non-invading-duct].
abstract: OBJECTIVE
  The clinical significance of sentinel lymph node biopsy for staging patients with ductal carcinoma in situ has not yet been solved. Determining the role of this method for the treatment of in situ ductal carcinoma has been the aim of this study.
  
  
  METHODS
  Dual agent guided sentinel lymph node biopsy with preoperative lymphoscintigraphy was performed on 36 patients with breast ductal carcinoma in situ from January 2001 to March 2004 at the Department of General and Thoracic Surgery, National Institute of Oncology, Budapest. Completion axillary lymph node dissection was not performed routinely. The sentinel lymph nodes were histologically examined at 0.5-1 mm levels with routine hematoxylin and eosin staining.
  
  
  RESULTS
  One patient has been excluded from the final analysis because of contralateral invasive breast cancer and simultaneous local recurrence in her medical history. Micro- or submicrometastases were found in 2 patients. If our patient number is completed with the 5 patients operated on for ductal carcinoma in situ during the period of our feasibility study (from December 1997 to March 2000) then the rate of patients with positive sentinel lymph node(s) will be 5% (2/40). All metastases were less than 2 mm in size. Metastases were found only in patients with high risk, extended ductal carcinoma in situ who finally underwent mastectomy. Completion axillary lymphadenectomy has not been performed even for patients with positive sentinel lymph node and no regional recurrence has yet been observed.
  
  
  CONCLUSIONS
  Our results corresponds well to the international ones. Performing sentinel lymph node biopsy for ductal carcinoma in situ of the breast is not recommended on the basis of the international and our own experiences. Sentinel lymph node biopsy is essential for patients undergoing mastectomy. In other cases when preoperative diagnostic studies do not verify invasion unequivocally we advise to perform sentinel lymph node biopsy (if necessary) after the final histological result of the excised breast specimen.
authors.affiliation: Országos Onkológiai Intézet, Altalános-és Mellkassebészeti Osztály.
authors.forename: Klára
authors.initials: K
authors.lastname: Török
authors.forename: Gábor
authors.initials: G
authors.lastname: Péley
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Mátrai
authors.forename: Mária
authors.initials: M
authors.lastname: Bidlek
authors.forename: Eva
authors.initials: E
authors.lastname: Szabó
authors.forename: István
authors.initials: I
authors.lastname: Sinkovics
authors.forename: Csaba
authors.initials: C
authors.lastname: Polgár
authors.forename: Emil
authors.initials: E
authors.lastname: Farkas
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Orosz
authors.forename: István
authors.initials: I
authors.lastname: Köves
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008408:Mastectomy / Q000379:methods; D008875:Middle Aged; D009367:Neoplasm Staging; D021701:Sentinel Lymph Node Biopsy