Effects of flunixin meglumine on selected clinicopathologic variables, and serum testosterone concentration in stallions after endotoxin administration.
Four clinically normal stallions were infused intravenously with endotoxin (LPS) from Escherichia coli 055:B5 at a dose of 0.3 microg/kg b.w. and four stallions were treated with flunixin meglumine (FM) as a single intravenous injection at a dose of 1.1 mg/kg b.w., 5 min after the infusion of LPS. In response to endotoxin infusion, stallions' reaction was fever (increased rectal and scrotal skin temperature), increased heart rate (HR) and leucopenia. Administration of endotoxin also influenced the level of testosterone (decrease at 3-24 h and increase at 48-72 h after LPS administration) in the blood serum. FM treatment prevented an endotoxin-induced increase in rectal and scrotal skin temperature, HR, with no influence on the decrease of leucocytes. Administration of FM only had a significant effect on the latter changes (at 24-72 h) of serum testosterone concentration after addition of endotoxin.
Danek
J
J
Department of Horse Diseases, National Veterinary Research Institute, 85-090 Bydgoszcz, Poland. jdanek@wp.pl
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019540:Area Under Curve; D003002:Clonixin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004731:Endotoxins / Q000378:metabolism / Q000633:toxicity*; D006339:Heart Rate / Q000187:drug effects; D006734:Horse Diseases / Q000139:chemically induced / Q000188:drug therapy*; D006736:Horses; D008297:Male; D013739:Testosterone / Q000097:blood*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004731:Endotoxins; D013739:Testosterone; C014558:flunixin meglumine; D003002:Clonixin