Tumour-induced immune modulation of sentinel lymph nodes.
Sentinel lymph nodes (SLNs), being the first nodes to receive lymph from a primary tumour and the preferential site of initial tumour metastases, are intensively exposed to the bioactive products of tumour cells and other associated cells. This makes them ideal for studies of the factors that determine selective tissue susceptibility to metastases. We postulate that tumour-induced immune modulation of SLNs facilitates lymph-node metastases by inhibiting the generation of tumour-specific cytotoxic T cells that are active against tumour cells of primary and metastatic melanomas. Immune modulation of the lymph nodes can be reversed by granulocyte/macrophage colony-stimulating factor (GM-CSF), a finding that has implications for the future therapy of lymph-node metastases.
Cochran
Alistair J
AJ
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California at Los Angeles, California 90095, USA. ACochran@mednet.ucla.edu
Huang
Rong-Rong
RR
Lee
Jonathan
J
Itakura
Eijun
E
Leong
Stanley P L
SP
Essner
Richard
R
D000818:Animals; D002465:Cell Movement; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D008207:Lymphatic Metastasis / Q000276:immunology* / Q000473:pathology*; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D021701:Sentinel Lymph Node Biopsy