[Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats].
To investigate effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats.



Chronic transauricular kindled seizures was induced by repeated application of initially subconvulsive electrical stimulation through ear-clip electrodes once every 24 h until the occurrence of 3 consecutive clonic-tonic seizures. A passive avoidance test was used to measure memory retention ability. Morphological changes in neurons of hippocampal CA1 region was examined after HE staining. Histamine, gamma-aminobutyric acid (GABA) and glutamate levels in the hippocampus were measured by high performance liquid chromatography (HPLC).



Chronic transauricular kindled seizures impaired passive-avoidance test memory retention in rats. The damaged CA1 neurons were observed and histamine content in the hippocampus markedly decreased 24 h after the end of kindling in the chronic transauricular kindled rats.



Chronic transauricular kindled seizure impaired passive-avoidance test memory retention, and it might be due to the damaged CA1 neurons and a decrease of histamine in the hippocampus induced by epilepsy.
Li
Qing
Q
Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310031, China.
Liu
Lu-ying
LY
Zhu
Yuan-yuan
YY
Zhou
Wen-xia
WX
Chen
Zhong
Z
D000818:Animals; D001362:Avoidance Learning; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006632:Histamine / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005680:gamma-Aminobutyric Acid; D006632:Histamine