Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.
OBJECTIVE
The present study aimed to evaluate the effect of metformin exposure during pregnancy on neonates of polycystic ovarian syndrome (PCOS) patients.


METHODS
Neonatal outcomes of 33 women with PCOS treated with metformin during pregnancy were compared to neonatal outcomes of 66 normal healthy women in a retrospective case-control study.


RESULTS
The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls. After controlling for pregnancy complications, this observation became only marginally statistically significant.


CONCLUSIONS
Although metformin is an attractive option for induction of ovulation in PCOS patients, there is a need for more evidence related to its safety during pregnancy.
Kovo
Michal
M
Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon, Israel. michalkovo@hotmail.com
Weissman
Ariel
A
Gur
Dvir
D
Levran
David
D
Rotmensch
Sigi
S
Glezerman
Marek
M
D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000453:epidemiology; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012189:Retrospective Studies
D007004:Hypoglycemic Agents; D008687:Metformin