Role of the innate immune system and host-commensal mutualism.
Host organisms live in intimate contact with indigenous microflora. The interactions between the host and commensal microbiota are highly complex and heterogeneous. A growing body of evidence indicates that commensal symbionts provide many benefits to the host physiology, particularly in the gastrointestinal system. The molecular mechanisms of the mutualistic interactions between the host and commensals are largely unknown but can be due either to bioactivity of the commensals or to the reaction of the host immune system to the commensal-derived products. Recent advances in our understanding of the innate immune system allow re-evaluation of some of the older findings regarding the mechanisms of benefits conferred by microflora. Here we review the examples of the benefits of host-commensal interactions that are due to recognition of commensal microbial products by the host innate immune system.
Rakoff-Nahoum
S
S
Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Medzhitov
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R
D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology*; D008221:Lymphoid Tissue / Q000276:immunology* / Q000382:microbiology; D013559:Symbiosis / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
D051193:Toll-Like Receptors