Nickel-catalyzed cyclization of 2-iodoanilines with aroylalkynes: an efficient route for quinoline derivatives.
An efficient and convenient nickel-catalyzed cyclization of 2-iodoanilines with alkynyl aryl ketones to give 2,4-disubstituted quinolines was developed. The reaction can be employed for the synthesis of naturally occurring quinoline derivatives in good yields. On the basis of the regiochemistry of the products, the possible pathway for the reaction is via the formation of o-aminochalcone.
Korivi
Rajendra Prasad
RP
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
Cheng
Chien-Hong
CH
D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
D000480:Alkynes; D000814:Aniline Compounds; D011804:Quinolines; D009532:Nickel; C037219:quinoline