title: [Change of oxygen free radical in patients with obstructive sleep apnea hypopnea syndrome after the operation of uvulopalatopharyngoplasty].
abstract: OBJECTIVE
  To explore the mechanism of multiple organ dysfunction in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) by observing the change of SOD,GSH-PX and MDA after uvulopalatopharyngoplasty (UPPP).
  
  
  METHODS
  Colorimetric method was used to examine both the activity of SOD,GSH-PX and the content of MDA before and one month after UPPP in 30 patients with OSAHS. Thirty healthy people were chosen as normal control.
  
  
  RESULTS
  Before UPPP, the activity of SOD, GSH-PX and the content of MDA were (106.3 +/- 41.2) nmol/L (compared with the control group, P < 0.05), (61.8 +/- 6.5) kU/L (P < 0.05) and (6.27 +/- 1.73) mmol/L (P < 0.05) respectively; yet after the operation, the results were(128.5 +/- 33.1) nmol/L (compared with the control group, P > 0.05), (64.6 +/- 6.1) kU/L (P > 0.05) and (1.32 +/- 0.58) mmol/L (P > 0.05).
  
  
  CONCLUSIONS
  The metabolism of oxygen free radical was badly imbalanced in patients with OSAHS, yet one month after UPPP, it was recovered to normal. This suggested that the metabolism imbalance of oxygen free radical was contributed to multiple organ dysfunction in such patients.
authors.affiliation: Votional Lab of Otolaryngology, P. R. China of Shandong University, Jinan 250012, China. tangsh@sdu.edu.cn
authors.forename: Shuhai
authors.initials: S
authors.lastname: Tang
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Li
authors.forename: Weizhi
authors.initials: W
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures; D010159:Palate / Q000601:surgery; D010614:Pharynx / Q000601:surgery; D011184:Postoperative Period; D017382:Reactive Oxygen Species / Q000378:metabolism*; D020181:Sleep Apnea, Obstructive / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D014609:Uvula / Q000601:surgery
chemical_list: D017382:Reactive Oxygen Species