Transvalencin Z, a new antimicrobial compound with salicylic acid residue from Nocardia transvalensis IFM 10065.
Transvalencin Z was isolated from a culture broth of Nocardia transvalensis IFM 10065, a clinical isolate from a Japanese patient with actinomycotic mycetoma. The transvalencin Z structure was determined using NMR and mass spectrometric analyses. The structure is similar to a partial structure of siderophores such as mycobactins and nocobactins, but the compound has no cytotoxic activity. Transvalencin Z shows a strong antimicrobial activity against Gram-positive bacteria, but shows no activity against Gram-negative bacteria, fungi and tumor cells.
Mukai
Akira
A
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Fukai
Toshio
T
Matsumoto
Yuko
Y
Ishikawa
Jun
J
Hoshino
Yasutaka
Y
Yazawa
Katsukiyo
K
Harada
Ken-ichi
K
Mikami
Yuzuru
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009615:Nocardia / Q000378:metabolism*; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020156:Salicylic Acid
D000900:Anti-Bacterial Agents; D010080:Oxazoles; D012459:Salicylates; C513066:transvalencin Z; D020156:Salicylic Acid