Is being plastic fantastic? Mechanisms of altered plasticity after developmental traumatic brain injury.
Traumatic brain injury (TBI) is predominantly a clinical problem of young persons, resulting in chronic cognitive and behavioral deficits. Specifically, the physiological response to a diffuse biomechanical injury in a maturing brain can clearly alter normal neuroplasticity. To properly evaluate and investigate developmental TBI requires an understanding of normal principles of cerebral maturation, as well as a consideration of experience-dependent changes. Changes in neuroplasticity may occur through many age-specific processes, and our understanding of these responses at a basic neuroscience level is only beginning. In this article, we will particularly discuss mechanisms of TBI-induced altered developmental plasticity such as altered neurotransmission, distinct molecular responses, cell death, perturbations in neuronal connectivity, experience-dependent 'good plasticity' enhancements and chronic 'bad plasticity' sequelae. From this summary, we can conclude that 'young is not always better' and that the developing brain manifests several crucial vulnerabilities to TBI.
Giza
Christopher C
CC
Division of Pediatric Neurology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. cgiza@mednet.ucla.edu
Prins
Mayumi L
ML
D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism / Q000503:physiopathology*; D001930:Brain Injuries / Q000378:metabolism / Q000503:physiopathology*; D002454:Cell Differentiation / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D009410:Nerve Degeneration / Q000209:etiology / Q000503:physiopathology; D009415:Nerve Net / Q000254:growth & development / Q000378:metabolism / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D009419:Nerve Tissue Proteins