[Hyperlipidemia and hyperglycemia prevalence in obese children: increased risk of cardiovascular disease?].
In Venezuela, cardiovascular diseases have represented the first mortality cause since year 1967. Evidence have shown that early lesion of coronary atherosclerosis can be observed at infancy in close association to obesity and diabetes, suggesting that preventive measures should be initiated at that time.


OBJECTIVE
To study presence of hyperlipidemia or hyperglicemia in obese children as risk indicators.


METHODS
121 children (aged 8.7 +/- 3.43 years), with body mass index above 90th percentile for age (Fundacredesa) were studied. Serum cholesterol and its fractions (HDL-C and LDL-C), triglycerides and fasting glucose by enzymatic-colorimetric methods were determined, Cut-off points from Fundacredesa were used for cholesterol and triglycerides, while from National Cholesterol Education Program and American Diabetes Association, were used for LDL-C and HDL-C, and glucose, respectively. Children were grouped by age: Group 1: 2-5.11 years (19%); Group 2: 6-8.11 years (28.1%); and Group 3: elder than 9 years (52.9%). Statistical analysis was performed considering gender and age.


RESULTS
Mean values for cholesterol were at risk level in males Group 1. Mean values for HDL-c were at risk level for girls Group 1 and 3 and males Group 3. Mean values for triglycerides were at risk level for girls Group 1 and 3 and males Group 2; but high levels were found in males from Group 1 and 3. LDL-C was at aceptable values for all the groups. No hyperglicemia was found.


CONCLUSIONS
Low and at risk HDL-c and high triglycerides as lipid profile in these obese children indicate a high risk for cardiovascular disease, being males the more affected. A high proportion of the children fulfilled three criteria for Metabolic Syndrome. Dietary control and modification on food pattern and physical activity should be implemented.
Marcano
M
M
Centro de Investigaciones en Nutrición Dr. Eleazar Lara Pantin, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela. marcanom@uc.edu.ve
Solano
L
L
Pontiles
M
M
D000367:Age Factors; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D006949:Hyperlipidemias / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D014687:Venezuela / Q000453:epidemiology
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol