title: [Studies on the association between beta 2-glycoprotein I and hepatotropism of hepatitis B virus].
abstract: OBJECTIVE
  To further study the binding character of hepatitis B surface antigen (HBsAg) and beta 2-glycoprotein I (beta2GP I) and to explore whether beta2GP I plays an important role in the hepatotropism of hepatitis B virus.
  
  
  METHODS
  Using Western blot technique, we observed the binding character of the HBsAg with reduced and non-reduced beta2GP I.
  
  
  RESULTS
  rHBsAgs with reduced and non-reduced beta2GP I showed identical binding activity.
  
  
  CONCLUSIONS
  The binding activity of HBsAg is dependent on tandem residues, but not on conformational structures of beta2GP I. There is a specific binding between HBV and beta2GP I, which may play an important role in HBV infection and is one of the reasons of hepatotropism of HBV.
authors.affiliation: Department of Gastroenterology, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Yan-hang
authors.initials: YH
authors.lastname: Gao
authors.forename: Pu-jun
authors.initials: PJ
authors.lastname: Gao
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi
authors.forename: Tong-yu
authors.initials: TY
authors.lastname: Tang
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: Piao
authors.forename: Han-yi
authors.initials: HY
authors.lastname: Yang
mesh_terms: D006509:Hepatitis B / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D014759:Viral Envelope Proteins / Q000097:blood; D053482:beta 2-Glycoprotein I / Q000097:blood*
chemical_list: D006514:Hepatitis B Surface Antigens; D014759:Viral Envelope Proteins; D053482:beta 2-Glycoprotein I