title: Liver metastases: 3D shape-based analysis of CT scans for detection of local recurrence after radiofrequency ablation.
abstract: This HIPAA-compliant pilot study had internal review board approval; informed consent was waived. The purpose was to determine retrospectively the diagnostic performance of a computer-aided three-dimensional (3D) analytic tool for assessing local recurrences of liver metastases by quantifying shape changes in ablated tumors on computed tomographic (CT) scans for follow-up of radiofrequency (RF) ablation. Positron emission tomographic and long-term CT follow-up images were reference standards. Fifty-six follow-up CT scans of 12 liver metastases (mean size, 4.0 cm) in nine patients treated with RF ablation were retrospectively analyzed. After the 1st month following RF ablation, the 3D analytic tool helped quantify ablated tumor shape variations and revealed recurrences even in the absence of abnormal enhancement (sensitivity, seven of seven; specificity, three of five). The 3D tool would have revealed a recurrence before it was reported clinically in two patients. Although results are preliminary, a 3D analytic tool based on shape may be useful in assessing RF ablation results.
authors.affiliation: Department of Radiology, University Hospital Michallon, BP 217, 38043 Grenoble, France; TIMC-IMAG-CNRS Laboratory, Grenoble, France. Ivan.Bricault@imag.fr
authors.forename: Ivan
authors.initials: I
authors.lastname: Bricault
authors.forename: Ron
authors.initials: R
authors.lastname: Kikinis
authors.forename: Paul R
authors.initials: PR
authors.lastname: Morrison
authors.forename: Eric
authors.initials: E
authors.lastname: Vansonnenberg
authors.forename: Kemal
authors.initials: K
authors.lastname: Tuncali
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Silverman
mesh_terms: D000368:Aged; D017115:Catheter Ablation; D003936:Diagnosis, Computer-Assisted; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010865:Pilot Projects; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed