title: The impact of environment in comparison with moderate physical exercise and dietary restriction on BDNF in the cerebral parietotemporal cortex of aged Sprague-Dawley rats.
abstract: OBJECTIVE
  Moderate physical exercise, dietary restriction as well as enriched environment in separate studies have been reported to delay some of the adverse effects of aging on brain function, parallel to an increase in brain-derived neurotrophic factor (BDNF). In order to elucidate these influences in a comparative setting, we examined the tissue concentrations of BDNF in the cerebral parietotemporal cortex of old Sprague-Dawley rats.
  
  
  METHODS
  Male Sprague-Dawley rats were divided randomly into six groups, living from 5 months (baseline group BL) up to 23 months of age as follows: voluntary running in wheels (RW), food restricted by feeding to pair weight with RW animals (PW), forced running on treadmills (TM), and sedentary controls with ad libitum access to food, either housed individually (S1) or in groups of 4 animals (S4). BDNF concentrations were determined by a commercially available ELISA.
  
  
  RESULTS
  We found higher BNDF concentrations in the 5 months old animals than in the 23 months old animals of group S1. The old sedentary group S4 showed significantly higher BNDF concentrations in comparison with the old individually caged groups RW, TM, PW and S1. Their BNDF concentrations were even higher than those of the young baseline group.
  
  
  CONCLUSIONS
  Our data suggest that housing and social interactions have more influence on BDNF concentrations in the cerebral parietotemporal cortex of aging Sprague-Dawley rats than physical exercise and food restriction.
authors.affiliation: Institute of Physiology, Department of Natural Sciences, University of Veterinary Medicine Vienna, Vienna, Austria. alois.strasser@vu-wien.ac.at
authors.forename: Alois
authors.initials: A
authors.lastname: Strasser
authors.forename: Monika
authors.initials: M
authors.lastname: Skalicky
authors.forename: Michaela
authors.initials: M
authors.lastname: Hansalik
authors.forename: Andrus
authors.initials: A
authors.lastname: Viidik
mesh_terms: D000367:Age Factors; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis*; D031204:Caloric Restriction; D002540:Cerebral Cortex / Q000378:metabolism*; D004780:Environment, Controlled; D006799:Housing, Animal; D008297:Male; D023421:Models, Animal; D010805:Physical Conditioning, Animal / Q000523:psychology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012934:Social Isolation
chemical_list: D019208:Brain-Derived Neurotrophic Factor