Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies.
With the growing interest in clinical interventions that involve medical devices, the role for new biomaterials in modern medicine is currently expanding at a phenomenal rate. Failure of most implant materials stems from an inability to predict and control biological phenomena, such as protein adsorption and cell interaction, resulting in an inappropriate host response to the materials. Contemporary advances in biological investigation are starting to shift focus in the biomaterials field, in particular with the advent of high-throughput methodologies for gene and protein expression profiling. Here, we examine the role that emerging transcriptomic and proteomic technologies could play in relation to biomaterial development and usage. Moreover, a number of studies are highlighted which have utilized such approaches in order to try to create a deeper understanding of cell-biomaterial interactions and, hence, improve our ability to predict and control the biocompatibility of new materials.
Gallagher
William M
WM
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. william.gallagher@ucd.ie
Lynch
Iseult
I
Allen
Lorcan T
LT
Miller
Ian
I
Penney
Stephen C
SC
O'Connor
Darran P
DP
Pennington
Stephen
S
Keenan
Alan K
AK
Dawson
Kenneth A
KA
D001672:Biocompatible Materials; D040901:Proteomics; D012333:RNA, Messenger / Q000235:genetics*
D001672:Biocompatible Materials; D012333:RNA, Messenger