title: Myopathy in thiamine deficiency: analysis of a case.
abstract: BACKGROUND
  Tenderness in the limb muscles has been reported anecdotally in patients with beriberi neuropathy, but clinical effects of thiamine deficiency on skeletal muscle have received little attention.
  
  
  OBJECTIVE
  To describe a patient with thiamine deficiency who manifested myopathic symptoms and responded well to thiamine supplementation.
  
  
  METHODS
  A 26-year-old woman with neuropathy and heart failure associated with thiamine deficiency also complained of myalgia and weakness, most troublesome in the proximal portions of the limbs.
  
  
  RESULTS
  Serum creatine kinase, myoglobin, and aldolase concentrations were abnormally elevated. Magnetic resonance imaging of lower limb muscles demonstrated areas of high signal intensity in T2-weighted images and showed Gd-DTPA enhancement. A biopsy specimen from the quadriceps muscle showed myopathic changes without neurogenic changes. Abnormalities improved well with thiamine administration.
  
  
  CONCLUSIONS
  Myopathy may occur in patients with thiamine deficiency.
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Koike
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Watanabe
authors.forename: Akira
authors.initials: A
authors.lastname: Inukai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iijima
authors.forename: Keiko
authors.initials: K
authors.lastname: Mori
authors.forename: Naoki
authors.initials: N
authors.lastname: Hattori
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
mesh_terms: D000328:Adult; D015415:Biomarkers; D006332:Cardiomegaly / Q000209:etiology; D003402:Creatine Kinase / Q000097:blood; D004032:Diet; D004487:Edema / Q000209:etiology; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D005666:Fursultiamin / Q000627:therapeutic use; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D007866:Leg; D008279:Magnetic Resonance Imaging; D018908:Muscle Weakness / Q000209:etiology* / Q000473:pathology; D009211:Myoglobin / Q000097:blood; D012275:Oryza; D010146:Pain / Q000209:etiology* / Q000473:pathology; D013831:Thiamine / Q000097:blood; D013832:Thiamine Deficiency / Q000150:complications*
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D005666:Fursultiamin; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase; D013831:Thiamine