title: Macrochanneled poly (epsilon-caprolactone)/ hydroxyapatite scaffold by combination of bi-axial machining and lamination.
abstract: A combination of bi-axial machining and lamination was used to fabricate macrochanneled poly (epsilon-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds. Thermoplastic PCL/HA sheets with a thickness of 1 mm, consisting of a 40 wt% PCL polymer and 60 wt% HA particles, were bi-axially machined. The thermoplastic PCL/HA exhibited an excellent surface finish with negligible tearing of the PCL polymer and pull-out of the HA particles. The bi-axially machined sheets were laminated with a solvent to give permanent bonding between the lamina. This novel process produced three-directionally connected macrochannels in the dense PCL/HA body. The macrochanneled PCL/HA scaffold exhibited excellent ductility and reasonably high strength. In addition, good cellular responses were observed due to the osteoconductive HA particles.
authors.affiliation: School of Materials Science and Engineering, Seoul National University, Seoul, 151-742, Korea. kohyh@snu.ac.k
authors.forename: Young-Hag
authors.initials: YH
authors.lastname: Koh
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Bae
authors.forename: Jong-Jae
authors.initials: JJ
authors.lastname: Sun
authors.forename: In-Kook
authors.initials: IK
authors.lastname: Jun
authors.forename: Hyoun-Ee
authors.initials: HE
authors.lastname: Kim
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D011091:Polyesters; D012997:Solvents; C016240:polycaprolactone; D017886:Durapatite