title: Minimal-change nephrotic syndrome in a hematopoietic stem-cell transplant recipient.
abstract: BACKGROUND
  A 61-year-old woman received standard immunizations, including Haemophilus influenzae type B, diphtheria, tetanus toxoid, and unconjugated 23-valent pneumococcal vaccine (Pneumovax), Merck & Co., Inc., Whitehouse Station, NJ), 1 year after undergoing nonmyeloablative hematopoietic stem-cell transplantation for acute myelogenous leukemia. After 5 days, she developed fatigue with progressive weight gain and edema, and 14 days after immunization she presented with anasarca and was found to have acute renal failure and nephrotic proteinuria.
  
  
  METHODS
  Physical examination, serum chemistry, examination of urine sediment, renal ultrasound using Doppler scanning, 24 h urine collection, and renal biopsy.
  
  
  METHODS
  Minimal-change nephrotic syndrome with acute tubular injury.
  
  
  RESULTS
  Aggressive diuresis and oral corticosteroid therapy.
authors.affiliation: Harvard Medical School, Boston, MA 02115, USA. bhumphreys@partners.org
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Humphreys
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Vanguri
authors.forename: Joel
authors.initials: J
authors.lastname: Henderson
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Antin
mesh_terms: D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007114:Immunization / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy