HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy.
The Human Proteome Organisation (HUPO) initiated several projects focusing on the proteome analysis of distinct human organs. The Brain Proteome Project (BPP) is the initiative dedicated to the brain, its development and correlated diseases. Two pilot studies have been performed aiming at the comparison of techniques, laboratories and approaches. With the help of the results gained, objective data submission, storage and reprocessing workflow have been established. The biological relevance of the data will be drawn from the inter-laboratory comparisons as well as from the re-calculation of all data sets submitted by the different groups. In the following, results of the single groups as well as the centralised reprocessing effort will be summarised and compared, showing the added value of this concerted work.
Hamacher
Michael
M
Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany. Michael.Hamacher@rub.de
Apweiler
Rolf
R
Arnold
Georg
G
Becker
Albert
A
Blüggel
Martin
M
Carrette
Odile
O
Colvis
Christine
C
Dunn
Michael J
MJ
Fröhlich
Thomas
T
Fountoulakis
Michael
M
van Hall
André
A
Herberg
Friedrich
F
Ji
Jianguo
J
Ji
Juango
J
Kretzschmar
Hans
H
Lewczuk
Piotr
P
Lubec
Gert
G
Marcus
Katrin
K
Martens
Lennart
L
Palacios Bustamante
Nadine
N
Park
Young Mok
YM
Pennington
Stephen R
SR
Robben
Johan
J
Stühler
Kai
K
Reidegeld
Kai A
KA
Riederer
Peter
P
Rossier
Jean
J
Sanchez
Jean-Charles
JC
Schrader
Michael
M
Stephan
Christian
C
Tagle
Danilo
D
Thiele
Herbert
H
Wang
Jing
J
Wiltfang
Jens
J
Yoo
Jong Shin
JS
Zhang
Chenggang
C
Klose
Joachim
J
Meyer
Helmut E
HE
D000818:Animals; D001921:Brain / Q000378:metabolism*; D019295:Computational Biology; D030562:Databases, Protein; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism; D005260:Female; D006801:Humans; D051379:Mice; D015337:Multicenter Studies as Topic; D010865:Pilot Projects; D020543:Proteome / Q000032:analysis* / Q000378:metabolism
D020543:Proteome