Relapsing hypocupraemic myelopathy requiring high-dose oral copper replacement.
Adult-onset copper deficiency with neurological manifestations is a newly recognised syndrome. Long-term oral copper replacement therapy has been the mainstay of treatment in the literature. A case of relapsing hypocupraemic myelopathy responsive to increased doses of copper replacement is reported. Standard doses of copper may not be sufficient for all patients.
Prodan
C I
CI
Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. calin-prodan@ouhsc.edu
Bottomley
S S
SS
Holland
N R
NR
Lind
S E
SE
D003300:Copper / Q000172:deficiency* / Q000627:therapeutic use*; D003677:Deficiency Diseases / Q000150:complications; D005260:Female; D006801:Humans; D008875:Middle Aged; D013118:Spinal Cord Diseases / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
D003300:Copper