title: Reduction of gaseous microembolism during aortic valve replacement using a dynamic bubble trap.
abstract: Serious postoperative psycho-neurological dysfunction is at least partially attributed to the occurrence of gaseous microbubbles in the arterial line of extracorporeal circulation (ECC). Therefore, we investigated in a prospective randomized double blind study whether the usage of dynamic bubble trap (DBT) will reduce microbubble load of patients undergoing aortic valve replacement. Patients (n = 41) were divided into group I (GI, n = 22) with DBT introduced into the arterial line of ECC and group II (GII, n = 19) with placebo-DBT instead. Doppler ultrasonography was used for detection of microbubbles before and after DBT, and for detection of high intensity transient signals (HITS) within the middle cerebral artery. The recording time during ECC was divided into period 1 (P1, until aortic clamp removal) and period 2 (P2, clamp removal until the end of ECC). A significant reduction of microbubble load was found in GI only (p < 0.0001 for ECC; p < 0.0001 for P1; p < 0.0025 for P2). A significant difference in number of HITS between the groups was observed in P1 only (p < 0.002 left middle cerebral artery, p < 0.005 right middle cerebral artery), since in P2 the trapped air in left chamber can go to the supraaortal vessels without passing ECC. In conclusion the use of DBT cannot substitute careful venting after aortic declamping. Nevertheless, reduction of HITS in the cross-clamped period of ECC justifies the use of DBT in patients undergoing open chamber surgery.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Kerckhoff-Clinic, Benekestrasse 2-8, 61231 Bad Nauheim, Germany. m.schoenburg@kerckhoff-klinik.de
authors.forename: M
authors.initials: M
authors.lastname: Schönburg
authors.forename: T
authors.initials: T
authors.lastname: Ziegelhoeffer
authors.forename: B
authors.initials: B
authors.lastname: Kraus
authors.forename: A
authors.initials: A
authors.lastname: Mühling
authors.forename: M
authors.initials: M
authors.lastname: Heidt
authors.forename: U
authors.initials: U
authors.lastname: Taborski
authors.forename: T
authors.initials: T
authors.lastname: Gerriets
authors.forename: M
authors.initials: M
authors.lastname: Roth
authors.forename: S
authors.initials: S
authors.lastname: Hein
authors.forename: S
authors.initials: S
authors.lastname: Urbanek
authors.forename: W P
authors.initials: WP
authors.lastname: Klövekorn
mesh_terms: D001011:Aorta / Q000473:pathology; D001021:Aortic Valve / Q000473:pathology*; D004311:Double-Blind Method; D004618:Embolism, Air; D005112:Extracorporeal Circulation; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D008297:Male; D045423:Microbubbles; D015233:Models, Statistical; D011446:Prospective Studies; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods