Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: the SEARCH for Diabetes in Youth Study.
OBJECTIVE
Assessment of the prevalence of serum lipid abnormalities in US youth with type 1 or type 2 diabetes.


METHODS
The SEARCH for Diabetes in Youth Study was a cross-sectional, population-based study, conducted in six centers. Subjects were 2448 youth with diabetes who had a study examination. Outcome measures were fasting measures of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and non-HDL-C. Analysis was descriptive.


RESULTS
The overall prevalence of high TC concentration (>240 mg/dL) was 5%; the overall prevalence of high LDL-C (>160 mg/dL) was 3%, and the overall prevalence of high triglyceride (>400 mg/dL) was 2%. About half of the participants (48%) had an LDL-C concentration above the optimal level of 100 mg/dL. Among youth ages 10+, the prevalence of abnormal lipids was higher in type 2 (n = 283) than in type 1 diabetes (n = 1963): 33% versus 19% had TC concentration >200 mg/dL; 24% versus 15% had LDL-C concentration >130 mg/dL; 29% versus 10% had triglyceride concentration >150 mg/dL; 44% versus 12% had HDL-C concentration <40 mg/dL. Only 1% of youth were receiving pharmacologic therapy for dyslipidemia.


CONCLUSIONS
A substantial proportion of young patients with diabetes have abnormal serum lipids.
Kershnar
Ann K
AK
Research and Evaluation, Kaiser Permanente Southern California, 9449 East Imperial Highway, Downey, CA 90242, USA. Ann.K.Kershnar@kp.org
Daniels
Stephen R
SR
Imperatore
Giuseppina
G
Palla
Shana L
SL
Petitti
Diana B
DB
Pettitt
David J
DJ
Marcovina
Santica
S
Dolan
Lawrence M
LM
Hamman
Richard F
RF
Liese
Angela D
AD
Pihoker
Catherine
C
Rodriguez
Beatriz L
BL
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D008055:Lipids / Q000097:blood*; D008297:Male; D015995:Prevalence; D014481:United States / Q000453:epidemiology
D008055:Lipids