Determinants of health-related quality of life in patients with coronary artery disease.
BACKGROUND
Health-related quality of life (HRQL) is increasingly being assessed as an outcome parameter, especially in chronic diseases such as coronary artery disease (CAD), in which the goal of treatment is not only to prolong life but also to relieve symptoms and improve function.


METHODS
This study was carried out as a non-randomized prospective multicentre study.


METHODS
Patients (N = 432) with CAD were assessed at baseline, 1 and 3 months after treatment assignment [medication, percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)]. HRQL was assessed using the MacNew Heart Disease Health-related Quality of Life Questionnaire (MacNew) and the Short Form 36 (SF-36). Depressive and anxiety symptoms were assessed using the Hospital Anxiety and Depression Scale. Routine clinical data including disease severity were collected.


RESULTS
The short and intermediate-term results revealed HRQL differences between PCI and CABG in the month immediately after intervention despite the almost identical reduction in angina severity over the first month in both groups. PCI was associated with a relatively rapid increase in HRQL in the first month, with little further change by 3 months. In contrast, after CABG there was an initial deterioration in HRQL, which then improved significantly. The change in depression and anxiety score uniquely accounted for most of the change in the SF-36 (6%, 64%) and MacNew scales (4%, 69%), whereas treatment accounted for less than 1% in any HRQL scale score changes.


CONCLUSIONS
There appears to be evidence suggesting that HRQL changes after treatments in patients with CAD may be more strongly influenced by mood disturbance than by treatment methods.
Höfer
Stefan
S
Department of Medical Psychology and Psychotherapy, Innsbruck Medical University, Innsbruck, Austria. stefan.hoefer@uibk.ac.at
Doering
Stephan
S
Rumpold
Gerhard
G
Oldridge
Neil
N
Benzer
Werner
W
D015906:Angioplasty, Balloon, Coronary; D001007:Anxiety / Q000175:diagnosis; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000523:psychology / Q000628:therapy*; D003863:Depression / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000523:psychology*; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires