Antimicrobial activities of cinnamyl rifamycin derivatives, T-9 and T-11, against Mycobacterium tuberculosis and Mycobacterium avium complex (MAC) with special reference to the activities against intracellular MAC.
The mycobacterial activities of cinamyl rifamycin derivatives, T-9 and T-11, especially against extracellular and intracellular Mycobacterium avium complex residing within macrophages and type II pneumocytes were compared with those of other rifamycins. The activities of test rifamycins were found to be in the order rifalazil, rifabutin, T-9, T-11, and rifampicin.
Sato
Katsumasa
K
Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane, Japan.
Shimizu
Toshiaki
T
Dimova
Velitchka
V
Tomioka
Haruaki
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000382:microbiology; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000166:cytology / Q000382:microbiology; D012294:Rifamycins / Q000494:pharmacology*
C097448:3-(4-cinnamylpiperazinyl iminomethyl)rifamycin SV; D000900:Anti-Bacterial Agents; D012294:Rifamycins