title: Selenium: from cancer prevention to DNA damage.
abstract: Selenium (Se) is a dietary essential trace element with important biological roles. Accumulating evidence indicates that Se compounds possess anticancer properties. Se is specifically incorporated into proteins in the form of selenocysteine and non-specifically incorporated as selenomethionine in place of methionine. The effects of Se compounds on cells are strictly compositional and concentration-dependent. At supranutritional dietary levels, Se can prevent the development of many types of cancer. At higher concentrations, Se compounds can be either cytotoxic or possibly carcinogenic. The cytotoxicity of Se is suggested to be associated with oxidative stress. Accordingly, sodium selenite, an inorganic Se compound, was reported to induce DNA damage, particularly DNA strand breaks and base damage. In this review we summarize the various activities of Se compounds and focus on their relation to DNA damage and repair. We discuss the use of Saccharomyces cerevisiae for identification of the genes involved in Se toxicity and resistance.
authors.affiliation: Laboratory of Molecular Genetic, Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovak Republic.
authors.forename: Lucia
authors.initials: L
authors.lastname: Letavayová
authors.forename: Viera
authors.initials: V
authors.lastname: Vlcková
authors.forename: Jela
authors.initials: J
authors.lastname: Brozmanová
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D012643:Selenium / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D016588:Anticarcinogenic Agents; D012643:Selenium