Quality of life improvement after hospital- based rehabilitation or home-based physical training in intermittent claudication.
BACKGROUND
The magnitude of potential changes in Quality-of-Life (QoL) after structured institution-based or home-based peripheral arterial disease (PAD) rehabilitation programs are largely unknown at present. This pilot study provides first QoL data after PAD rehabilitation or a home-based PAD training.


METHODS
In a non-randomized, open-label pilot study three groups of out-patients were compared: group 1 (n = 18) PAD rehabilitation; group 2 (n = 17) PAD rehabilitation + clopidogrel 75 mg once daily; group 3 (n = 20) home-based training. The training period was 3 months, which was followed by a 3-month observation phase (without prescribed training). The institution-based rehabilitation program consisted of 3 training hours per week whereas patients training at home were instructed to walk for 1 hour per day on an outdoor track. QoL assessment was performed using MOS SF-36, PAVK-86 and PAD-WIQ questionnaires.


RESULTS
At baseline background variables, demographics and claudication distances were comparable between groups. After three months of training the percentage changes for the initial and the absolute claudication distance (ICD, ACD) for groups 1, 2, and 3 amounted to 164%, 201%, 44% (ICD) and 83%, 131%, 5% (ACD), respectively. Statistically significant QoL improvements were recorded for physical functions, pain and disease related anxiety in all three study groups; statistically significant inter-group differences were not found.


CONCLUSIONS
In sharp contrast to the development of the claudication distances the improvement in QoL, found after 3 months of training, was comparable and not consistently different between the groups.
Imfeld
S
S
Department of Angiology, University of Basel Medical School, University Hospital, Petersgraben 4, CH-4031 Basel, Switzerland. laba_angioresearch_kbs@ftml.net
Singer
L
L
Degischer
S
S
Aschwanden
M
M
Thalhammer
C
C
Labs
K-H
KH
Jaeger
K A
KA
D000368:Aged; D000553:Ambulatory Care; D000077144:Clopidogrel; D003131:Combined Modality Therapy; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007383:Intermittent Claudication / Q000175:diagnosis / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D010865:Pilot Projects; D011788:Quality of Life / Q000523:psychology*; D012047:Rehabilitation Centers; D011795:Surveys and Questionnaires; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
D005343:Fibrinolytic Agents; D000077144:Clopidogrel; D013988:Ticlopidine