title: Association of takotsubo cardiomyopathy and long QT syndrome.
abstract: A young woman presented with takotsubo cardiomyopathy after a syncopal attack caused by torsades de pointes. Two-dimensional echocardiography on admission showed left ventricular apical akinesis (ballooning) and basal hyperkinesis, compatible with takotsubo cardiomyopathy. This gradually normalized in 2 months. ECG on admission showed remarkable QT prolongation, U waves, and negative T waves, which also gradually normalized. Coronary angiography revealed no organic stenosis; however, acetylcholine provocation test caused the QT interval to again become prolonged. During treadmill exercise stress testing, the QT interval shortened as heart rate increased. Therefore, without genetic analysis, this patient was considered to have sporadic long QT syndrome in which takotsubo cardiomyopathy developed after the syncopal attack caused by torsades de pointes.
authors.affiliation: Division of Cardiology, Saitama Medical Center, Saitama Medical University, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Sasaki
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Nishioka
authors.forename: Takashi
authors.initials: T
authors.lastname: Akima
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Tabata
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Akanuma
authors.forename: Akimi
authors.initials: A
authors.lastname: Uehata
authors.forename: Bonpei
authors.initials: B
authors.lastname: Takase
authors.forename: Shuichi
authors.initials: S
authors.lastname: Katsushika
authors.forename: Kazushige
authors.initials: K
authors.lastname: Isojima
authors.forename: Shingo
authors.initials: S
authors.lastname: Ohtomi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yoshimoto
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D013575:Syncope / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D016171:Torsades de Pointes / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D014463:Ultrasonography