Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence.
Repression of virulence by Staphylococcus aureus strains from different Agr groups has been demonstrated in vitro and is proposed as a means of competitive interference. Here, using the insect Manduca sexta, we show for the first time that this interference also occurs in vivo within a mixed population.
Fleming
Vicki
V
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
Feil
Ed
E
Sewell
Andrew K
AK
Day
Nicholas
N
Buckling
Angus
A
Massey
Ruth C
RC
D000818:Animals; D000898:Antibiosis; D001426:Bacterial Proteins / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D018402:Manduca / Q000382:microbiology*; D023421:Models, Animal; D013211:Staphylococcus aureus / Q000254:growth & development* / Q000472:pathogenicity*; D015534:Trans-Activators / Q000502:physiology*; D014774:Virulence / Q000502:physiology*
C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; D015534:Trans-Activators