Suppression of gastric acid production by proton pump inhibitor treatment facilitates colonization of the large intestine by vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in clindamycin-treated mice.
Proton pump inhibitor treatment of clindamycin-treated mice elevated the gastric pH and facilitated the establishment of colonization of the large intestine by vancomycin-resistant Enterococcus spp. (75 to 80%, versus 20 to 25% for saline-treated controls) and Klebsiella pneumoniae (90%, versus 30% for saline-treated controls). These findings demonstrate a mechanism by which proton pump inhibitor therapy could contribute to the dissemination of nosocomial pathogens.
Stiefel
Usha
U
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.
Rao
Agam
A
Pultz
Michael J
MJ
Jump
Robin L P
RL
Aron
David C
DC
Donskey
Curtis J
CJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D007420:Intestine, Large / Q000187:drug effects / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000254:growth & development*; D051379:Mice; D054328:Proton Pump Inhibitors; D020713:Vancomycin Resistance / Q000502:physiology*
D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D002981:Clindamycin