Thyroid involvement with Langerhans cell histiocytosis in a 3-year-old male.
We report on the thyroid involvement with Langerhans cell histiocytosis (LCH) in a 3-year-old male. The patient presented with goiter and primary hypothyroidism. His goiter caused life-threatening airway obstruction. He developed locally invasive disease 4 years after his response to LCH therapy. LCH should be suspected as a cause of goiter and thyroidectomy is recommended.
Burnett
Aaron
A
Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, New York, USA.
Carney
David
D
Mukhopadhyay
Sanjay
S
Scalzetti
Ernest M
EM
Leino
Daniel
D
Souid
Abdul-Kader
AK
D000402:Airway Obstruction / Q000209:etiology; D002291:Carcinoma, Papillary / Q000150:complications; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006042:Goiter / Q000209:etiology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D013959:Thyroid Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D013964:Thyroid Neoplasms / Q000150:complications; D013965:Thyroidectomy; D013967:Thyroiditis, Autoimmune / Q000150:complications
D015122:Mercaptopurine; D011241:Prednisone; D008727:Methotrexate