CD30+ anaplastic large cell lymphoma complicated by pyoderma gangrenosum with increased levels of serum cytokines.
We here present the case of a 5-yr-old girl with pyoderma gangrenosum (PG) in association with underlying CD30+ anaplastic large cell lymphoma with increased serum cytokine levels (interleukin-8, granulocyte colony-stimulating factor). An association between PG and increased cytokine levels was suggested. Even in children, dermatosis of PG should receive prompt careful evaluation for underlying hematological malignancy.
Saito
Shoji
S
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Yasui
Kozo
K
Hosoda
Waki
W
Ogawa
Mina
M
Kobayashi
Norimoto
N
Sakashita
Kazuo
K
Koike
Kenichi
K
D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D017730:Ki-1 Antigen / Q000378:metabolism; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D010014:Osteolysis / Q000209:etiology / Q000473:pathology; D017511:Pyoderma Gangrenosum / Q000209:etiology* / Q000276:immunology* / Q000473:pathology
D016207:Cytokines; D016209:Interleukin-8; D017730:Ki-1 Antigen; D016179:Granulocyte Colony-Stimulating Factor