title: Tropical--parameter estimation and simulation of reaction-diffusion models based on spatio-temporal microscopy images.
abstract: Tropical is a software for simulation and parameter estimation of reaction-diffusion models. Based on spatio-temporal microscopy images, Tropical estimates reaction and diffusion coefficients for user-defined models. Tropical allows the investigation of systems with an inhomogeneous distribution of molecules, making it well suited for quantitative analyses of microscopy experiments such as fluorescence recovery after photobleaching (FRAP).
  
  
  BACKGROUND
  Tropical is available free of charge for academic use at http://www.dkfz.de/tbi/projects/modellingAndSimulationOfCelluarSystems/tropical.jsp after signing a material transfer agreement.
authors.affiliation: Department of Theoretical Bioinformatics, German Cancer Research Center Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Ulrich
authors.forename: Constantin
authors.initials: C
authors.lastname: Kappel
authors.forename: Joel
authors.initials: J
authors.lastname: Beaudouin
authors.forename: Stefan
authors.initials: S
authors.lastname: Hezel
authors.forename: Jochen
authors.initials: J
authors.lastname: Ulrich
authors.forename: Roland
authors.initials: R
authors.lastname: Eils
mesh_terms: D000465:Algorithms; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D004058:Diffusion; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D008954:Models, Biological; D025941:Protein Interaction Mapping / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology*; D012984:Software