title: Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa.
abstract: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion of the oral mucosa of an unclear pathogenesis. We analyzed the profile of the inflammatory infiltrate in 12 cases of TUGSE by using immunohistochemical analysis and polymerase chain reaction-based repertoire analysis to detect T- and B-cell receptor gene rearrangements. The inflammatory infiltrate consisted in most cases of B and T lymphocytes, macrophages, abundant eosinophils, and large atypical cells. In 5 cases, CD30+ cells were found. Spectratyping analysis displayed a polyclonal rearrangement of the T-cell receptor g gene in 6 cases and oligoclonality in 5 cases. Monoclonality was observed in 1 case that also fulfilled histologic criteria for lymphoma. Healing was uneventful in all cases, including the one suspected of being lymphoma, with no recurrences in more than 2 years'follow-up. TUGSE can be regarded reactive. Some cases, however, may harbor a dominant clonal T-cell population; in these cases, long-term follow-up is mandatory.
authors.affiliation: Department of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Hirshberg
authors.forename: Ninette
authors.initials: N
authors.lastname: Amariglio
authors.forename: Sharon
authors.initials: S
authors.lastname: Akrish
authors.forename: Ran
authors.initials: R
authors.lastname: Yahalom
authors.forename: Hanna
authors.initials: H
authors.lastname: Rosenbaum
authors.forename: Elimelech
authors.initials: E
authors.lastname: Okon
authors.forename: Ilana
authors.initials: I
authors.lastname: Kaplan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D004247:DNA / Q000032:analysis; D004803:Eosinophilic Granuloma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D017730:Ki-1 Antigen / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000293:injuries / Q000378:metabolism / Q000473:pathology*; D019226:Oral Ulcer / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D016133:Polymerase Chain Reaction; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D014947:Wounds and Injuries / Q000150:complications / Q000473:pathology*
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen; D004247:DNA