title: Tau protein, the main component of paired helical filaments.
abstract: In this volume we commemorate the centennial of Alois Alzheimer's discovery of what was later known as Alzheimer's disease, named by Alzheimer's mentor, Emil Kraepelin. In a much more low level, our group remember in this issue a paper published twenty years ago. In that paper it was described that tau can self-polymerize and, at that time, it suggested that tau was not only a component of Alzheimer paired helical filaments, as indicated some months earlier during that year, 1986, but that it was the main component of Alzheimer paired helical filaments.
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CSIC-UAM). Facultad de Ciencias, Campus de Cantoblanco, Universidad Autónoma de Madrid, 28049 - Madrid. Spain. javila@cbm.uam.es
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D016874:Neurofibrillary Tangles / Q000473:pathology; D010766:Phosphorylation; D058225:Plaque, Amyloid / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins