Comment on "Cell type regulates selective segregation of mouse chromosome 7 DNA strands in mitosis".
Armakolas and Klar (Reports, 24 February 2006, p. 1146) suggested that segregation of mouse chromosome 7, after induction of a site-specific crossover between homologous chromosomes, is driven by a preferential inheritance of the old Watson and the old Crick DNA strands. However, this interpretation only considered half of the possible outcomes. The conjecture fails when all possible outcomes are examined.
Haber
James E
JE
Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02454-9110, USA. haber@brandeis.edu
D000818:Animals; D002454:Cell Differentiation; D002842:Chromatids / Q000502:physiology; D020090:Chromosome Segregation; D033481:Chromosomes, Mammalian / Q000502:physiology*; D003434:Crossing Over, Genetic; D004247:DNA / Q000378:metabolism; D004475:Ectoderm / Q000166:cytology; D004622:Embryo, Mammalian / Q000166:cytology; D004707:Endoderm / Q000166:cytology; D016195:G2 Phase; D051379:Mice; D008938:Mitosis; D011995:Recombination, Genetic; D013234:Stem Cells / Q000166:cytology
D004247:DNA