title: Central corneal thickness in patients with Weill-Marchesani syndrome.
abstract: OBJECTIVE
  To investigate whether central corneal thickness (CCT) is affected in patients with Weill-Marchesani syndrome (WMS) and to focus on its clinical significance.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Complete ocular examination was performed in case and control groups, and then the lowest reading of ten pachymetry measurements of the central cornea was taken as CCT.
  
  
  RESULTS
  All participants, case and controls, were female and age matched (P = .7). The mean of central corneal thickness in twelve eyes of six patients with WMS was thicker (631.5 +/- 25.9 microns) than 40 eyes of 20 normal persons (535.8 +/- 25.9 microns) in the control group (P < .0001).
  
  
  CONCLUSIONS
  Increased CCT seems to be a previously unrecognized aspect of WMS. This may lead to overestimation of intraocular pressure by applanation tonometers. Therefore, unusually thick CCT should be considered in interpreting the Goldmann tonometric reading in diagnosis and management of glaucoma in this rare syndrome.
authors.affiliation: Shiraz University of Medical Sciences, Department of Ophthalmology, Khalili Hospital, Shiraz, Iran. razeghinejad@yahoo.com
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Razeghinejad
authors.forename: Homayoon
authors.initials: H
authors.lastname: Safavian
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D003240:Connective Tissue Diseases / Q000235:genetics*; D003315:Cornea / Q000000981:diagnostic imaging / Q000473:pathology*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D013577:Syndrome; D014065:Tonometry, Ocular; D014463:Ultrasonography