Effect of imipramine on the behavior and cerebral 5-HT1A serotonin receptors in mice genetically predisposed to catalepsy.
Acute injection of imipramine to NPK mice hereditary predisposed to pinching catalepsy reduced immobility in the forced swimming test, but had no effect on catalepsy. Chronic treatment with imipramine reduced the severity of catalepsy and functional activity of 5-HT1A serotonin receptors, but did not modify their expression in the hippocampus. NPK mice can be a convenient model for studies of the effects of antidepressant.
Tikhonova
M A
MA
Laboratory of Behavioral Neurogenetics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk. mar-a-tikh@mail.ru
Lebedeva
V V
VV
Kulikov
A V
AV
Bazovkina
D V
DV
Popova
N K
NK
D018759:Adrenergic Uptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D002375:Catalepsy / Q000188:drug therapy* / Q000235:genetics; D002540:Cerebral Cortex / Q000737:chemistry; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000737:chemistry; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008818:Mice, Neurologic Mutants; D044282:Receptor, Serotonin, 5-HT1A / Q000032:analysis / Q000378:metabolism; D058829:Serotonin 5-HT1 Receptor Antagonists; D013550:Swimming
D018759:Adrenergic Uptake Inhibitors; D000929:Antidepressive Agents, Tricyclic; D058829:Serotonin 5-HT1 Receptor Antagonists; D044282:Receptor, Serotonin, 5-HT1A; D007099:Imipramine