Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU).
The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77+/-5% (n=4) for [18F]FBA and 46+/-5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.
Marik
Jan
J
Department of Biomedical Engineering, University of California Davis, 451 East Health Sciences Drive, CA 95616-5294, USA.
Sutcliffe
Julie L
JL
D001565:Benzoates / Q000138:chemical synthesis*; D005462:Fluorine Radioisotopes; D007553:Isotope Labeling; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013388:Succinimides / Q000138:chemical synthesis*
D001565:Benzoates; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D013388:Succinimides; C075713:N-succinimidyl-4-fluorobenzoate; C022893:4-fluorobenzoic acid