Hypocrellin D, a cytotoxic fungal pigment from fruiting bodies of the ascomycete Shiraia bambusicola.
A fungal pigment, hypocrellin D (1), together with three known perylenequinone derivatives hypocrellin A (2), B (3) and C (4), was isolated from the fruiting bodies of Shiraia bambusicola. Its structure was elucidated on the basis of spectral data including 2D NMR experiments. Hypocrellin D (1) significantly inhibited the growth of tumor cell lines Bel-7721, A-549 and Anip-973 with IC50 values of 1.8, 8.8, 38.4 microg/ml, respectively.
Fang
Li-Zhen
LZ
State Key Laboratory of Phytochemistry and Plant Resource in West China, Kunming Institute of Botany, Chinese Academy of Sciences.
Qing
Chen
C
Shao
Hong-Jun
HJ
Yang
Yi-Dong
YD
Dong
Ze-Jun
ZJ
Wang
Fei
F
Zhao
Wei
W
Yang
Wan-Qiu
WQ
Liu
Ji-Kai
JK
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D010860:Pigments, Biological; C513064:hypocrellin D; D010569:Perylene