title: Suppression of gastric acid production by proton pump inhibitor treatment facilitates colonization of the large intestine by vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in clindamycin-treated mice.
abstract: Proton pump inhibitor treatment of clindamycin-treated mice elevated the gastric pH and facilitated the establishment of colonization of the large intestine by vancomycin-resistant Enterococcus spp. (75 to 80%, versus 20 to 25% for saline-treated controls) and Klebsiella pneumoniae (90%, versus 30% for saline-treated controls). These findings demonstrate a mechanism by which proton pump inhibitor therapy could contribute to the dissemination of nosocomial pathogens.
authors.affiliation: Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.
authors.forename: Usha
authors.initials: U
authors.lastname: Stiefel
authors.forename: Agam
authors.initials: A
authors.lastname: Rao
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pultz
authors.forename: Robin L P
authors.initials: RL
authors.lastname: Jump
authors.forename: David C
authors.initials: DC
authors.lastname: Aron
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Donskey
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D007420:Intestine, Large / Q000187:drug effects / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000254:growth & development*; D051379:Mice; D054328:Proton Pump Inhibitors; D020713:Vancomycin Resistance / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D002981:Clindamycin