title: Solventless clay-promoted Friedel-Crafts reaction of indoles with alpha-amido sulfones: unexpected synthesis of 3-(1-arylsulfonylalkyl) indoles.
abstract: Friedel-Crafts reaction of indoles with alpha-amido sulfones in the presence of montmorillonite K-10 leads unexpectedly to 3-(1-arylsulfonylalkyl) indoles in good yield. The obtained products can be further desulfonylated under reductive or alkylative conditions giving linear and branched 3-substituted indoles.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, via S. Agostino 1, I-62032 Camerino, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ballini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Palmieri
authors.forename: Marino
authors.initials: M
authors.lastname: Petrini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Torregiani
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D002384:Catalysis; D000077215:Clay; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000538:Aluminum Silicates; D007211:Indoles; D013450:Sulfones; D000077215:Clay