Cooperation between different Cdc4/Fbw7 isoforms may be associated with 2-step inactivation of SCF(Cdc4) targets.
The recent description of a role for an SCF ubiquitin ligase in prolyl isomerization rather than ubiquitin ligation has led to a 2-step model for inactivation of cyclin E and, possibly, other SCF(Cdc4) targets in mammalian cells. In this proposed model, targets of SCF(Cdc4) are first subjected to prolyl isomerization, creating a signal for translocation and sequestration in the nucleolus, where they are then multiubiquitylated.
Reed
Steven I
SI
Department of Molecular Biology, MB-7, The Scripps Research Institute, La Jolla, California 92037, USA. sreed@scripps.edu
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D019927:Cyclin E / Q000378:metabolism*; D008954:Models, Biological; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism*
D018797:Cell Cycle Proteins; D019927:Cyclin E; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D020033:Protein Isoforms; D044843:SKP Cullin F-Box Protein Ligases; D019696:Peptidylprolyl Isomerase