Probability distribution analysis of force induced unzipping of DNA.
We present a semimicroscopic model of dsDNA by incorporating the directional nature of hydrogen bond to describe the force induced unzipping transition. Using exact enumeration technique, we obtain the force-temperature and the force-extension curves and compare our results with the other models of dsDNA. The model proposed by us is rich enough to describe the basic mechanism of dsDNA unzipping and predicts the existence of an "eye phase." We show oscillations in the probability distribution function during unzipping. Effects of stacking energies on the melting profile have also been studied.
Kumar
Sanjay
S
Department of Physics, Banaras Hindu University, Varanasi 221005, India. dgiri99@yahoo.com
Giri
Debaprasad
D
D001703:Biophysics / Q000379:methods; D002627:Chemistry, Physical / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D008962:Models, Theoretical; D008968:Molecular Conformation; D009010:Monte Carlo Method; D009991:Oscillometry; D011108:Polymers / Q000737:chemistry; D011336:Probability; D013696:Temperature; D013816:Thermodynamics
D011108:Polymers; D004247:DNA