title: One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition.
abstract: By combining three appropriately designed simple substrates, a programmed sequence involving an alpha-isocyano acetamide-based three-component reaction followed by a copper-catalyzed intramolecular [3+2] cycloaddition of alkyne and azide took place to afford complex macrocycles in moderate to good yields. One macrocycle and two heterocycles were produced with concurrent formation of five chemical bonds in this operationally simple process.
authors.affiliation: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale A. Avogadro, Via Bovio 6, 28100 Novara, Italy.
authors.forename: Tracey
authors.initials: T
authors.lastname: Pirali
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Tron
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu
mesh_terms: D047028:Macrocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D047028:Macrocyclic Compounds