Successful treatment of an endodermal sinus tumor of the vagina by chemotherapy alone: a rare case of an infant diagnosed by pathological examination of discharged tumor fragment.
A 7-month-old infant was noted to have vaginal bleeding that was accompanied by a discharged tumor fragment. The histological diagnosis was endodermal sinus tumor. Her serum alpha-fetoprotein (AFP) was increased to 358.7 ng/mL, and magnetic resonance imaging showed a 1.8 x 1.0 cm tumor in the vagina. She received combination chemotherapy with cyclophosphamide, pirarubicin, carboplatin, and etoposide. The tumor in the images disappeared and the serum level of AFP returned to the normal range after 2 cycles. Treatment was complete without surgical or radiological therapy. More than 45 months after the completion of chemotherapy, she is alive without signs of recurrence.
Shinkoda
Yuichi
Y
Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. shinkoda@nk-cc.go.jp
Tanaka
Satoru
S
Ijichi
Osamu
O
Yoshikawa
Hideki
H
Nonaka
Yukiko
Y
Tanabe
Takayuki
T
Nishikawa
Takuro
T
Ishikawa
Syuji
S
Okamoto
Yasuhiro
Y
Kaji
Tatsuru
T
Tahara
Hiroyuki
H
Takamatsu
Hideo
H
Nagata
Kohji
K
Kawano
Yoshifumi
Y
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018240:Endodermal Sinus Tumor / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D014625:Vaginal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology