title: Enantioselective Friedel-Crafts reaction of indoles with carbonyl compounds catalyzed by bifunctional cinchona alkaloids.
abstract: In this communication, we report an efficient asymmetric Friedel-Crafts reaction that, unprecedently, is applicable to a wide range of both indoles and carbonyls. The use of a readily accessible catalyst in combination with a high enantioselectivity that is insensitive to reaction concentration, temperature, air, and moisture should allow this reaction to provide useful enantioselective access to new chiral indole derivatives. [reaction: see text]
authors.affiliation: Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA.
authors.forename: Hongming
authors.initials: H
authors.lastname: Li
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Deng
mesh_terms: D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008967:Molecular Biology
chemical_list: D002930:Cinchona Alkaloids; D007211:Indoles