Lactate dehydrogenase-linked immunoglobulin Akappa in a patient with nonimmune chronic idiopathic neutropenia.
A 39-year-old patient with cervical cancer, stage Ia, was successfully treated by total hysterectomy. Then, after sustained neutropenia for more than 4 years and coincident with its exacerbation, the serum lactate dehydrogenase (LD) level started to elevate and reached a plateau. A test for antineutrophil antibody was negative and LD-3-linked IgAkappa, which may be responsible for high LD activity, was confirmed. The absolute number of blood NK cells was reduced, and a diagnosis of nonimmune chronic idiopathic neutropenia of adult was made. The successive occurrence of these 3 disorders may be based on interrelated immunological abnormalities.
Ihara
Noriko
N
Department of Medical Technology, Saitama Prefectural University, Saitama Medical School, Sannomiya 820, Koshigaya-City, Saitama 343-8540, Japan.
Murohashi
Ikuo
I
Itho
Masako
M
Amino
Ikuo
I
Yoshida
Katsuhiko
K
Matsuda
Akira
A
Bessho
Masami
M
D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood* / Q000201:enzymology; D001772:Blood Cell Count; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood* / Q000276:immunology; D007527:Isoenzymes / Q000097:blood; D007694:Killer Cells, Natural / Q000502:physiology; D007770:L-Lactate Dehydrogenase / Q000097:blood* / Q000737:chemistry; D009503:Neutropenia / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000601:surgery
D007070:Immunoglobulin A; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase