title: [Effect of fluid resuscitation on adhesion molecule and hemodynamics in patients with severe sepsis].
abstract: OBJECTIVE
  To explore the effects of fluid resuscitation on adhesion molecule and hemodynamics in patients with severe sepsis.
  
  
  METHODS
  Thirty-eight patients with severe sepsis were randomly divided into 2 groups: rapid fluid resuscitation group and general treatment group. Before and after fluid resuscitation, heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), lactic acid content, plasma P-selection and intercellular adhesion molecule-1 (ICAM-1) contents were determined.
  
  
  RESULTS
  There were no statistically significant differences in sex, age, resuscitation time and acute physiology and chronic health evaluation II (APACHE II) score between the two groups. Compared with general treatment group, more liquid volume but less aramine dosage were used (both P<0.05), MAP and CVP were increased after fluid resuscitation in rapid fluid resuscitation group (all P<0.05). The expression of P-selection, HR, contents of ICAM-1 and lactic acid were decreased (all P<0.05), and all of those were better than those of before fluid resuscitation.
  
  
  CONCLUSIONS
  Early rapid fluid resuscitation can improve hemodynamics and decrease the expression of adhesion molecule to retard the development of sepsis.
authors.affiliation: Intensive Care Unit, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, Zhejiang, China.
authors.forename: Xue-ling
authors.initials: XL
authors.lastname: Fang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fang
authors.forename: Guo-long
authors.initials: GL
authors.lastname: Cai
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015815:Cell Adhesion Molecules / Q000097:blood*; D019040:E-Selectin / Q000097:blood; D005260:Female; D005440:Fluid Therapy; D006339:Heart Rate; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D012151:Resuscitation / Q000379:methods*; D018805:Sepsis / Q000097:blood / Q000503:physiopathology / Q000628:therapy*
chemical_list: D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019007:P-Selectin; D018799:Intercellular Adhesion Molecule-1