Report of a patient with heparin-induced thrombocytopenia type II associated with IgA antibodies only.
Heparin-induced thrombocytopenia type II (HIT II) is usually mediated by immunoglobulin G (IgG) antibodies that lead to platelet activation via the FcgammaIIA-receptor. Here we describe a patient who developed HIT II after aortocoronary bypass surgery. His serum contained an antibody that was detectable by the heparin-induced platelet activation assay (HIPA) and by the ID-HPF4 particle agglutination assay. The flow cytometric analysis showed that the antibody was of the IgA class.
Meyer
Oliver
O
Institut für Transfusionsmedizin, Charité, Universitätsmedizin Berlin, Germany.
Aslan
T
T
Koster
A
A
Kiesewetter
H
H
Salama
A
A
D001323:Autoantibodies / Q000097:blood; D005434:Flow Cytometry; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007118:Immunoassay; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010978:Platelet Factor 4 / Q000276:immunology; D010979:Platelet Function Tests; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology*
D001323:Autoantibodies; D007070:Immunoglobulin A; D010978:Platelet Factor 4; D006493:Heparin