[The structure, function and recent reseach of pRNA].
In the bacteriophage phi29, a virus-encoded RNA(pRNA) is required for the packaging of its genomic DNA. Six pRNAs form a hexamer through pRNA/pRNA interaction to drive the DNA translocation motor, and ATP as the energy resource. Chimeric pRNAs can steadily combine with siRNA, ribozymes and anti-sense RNA, and then be transferred into the cancer cells and viral-infected cells by RNA nanotechnology. The continued study of pRNA will help us to understand the origin of the life and explore its possible applications.
Zhou
Hui
H
Laboratory of Biochemistry & Fermentation Engineering, Hunan Agricultural University, Changsha, China. paradise917@163.com
Lu
Xiang-Yang
XY
Tian
Yun
Y
Huang
Cheng-Jiang
CJ
D017103:Bacillus Phages / Q000235:genetics* / Q000254:growth & development; D001483:Base Sequence; D004279:DNA, Viral / Q000378:metabolism; D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D012367:RNA, Viral / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D004279:DNA, Viral; D012367:RNA, Viral