Insulin biosynthesis: the IREny of it all.
Recent studies have shown that the unfolded protein response (UPR) is essential for the survival of insulin-producing beta cells. Work in this issue of Cell Metabolism (Lipson et al., 2006) identifies a novel role for UPR activation in beta cell function by demonstrating that the UPR effector IRE1 is a positive regulator of glucose-stimulated proinsulin biosynthesis.
Corbett
John A
JA
Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, Missouri 63104.
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D000091342:Endoplasmic Reticulum Chaperone BiP; D004722:Endoribonucleases / Q000378:metabolism*; D004789:Enzyme Activation / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000096:biosynthesis* / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D018832:Molecular Chaperones / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010766:Phosphorylation; D011384:Proinsulin / Q000378:metabolism; D017510:Protein Folding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins; D007328:Insulin; D008565:Membrane Proteins; D018832:Molecular Chaperones; D009687:Nuclear Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D011384:Proinsulin; C403982:ERN2 protein, human; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases; D005947:Glucose