Dynamics and mechanics of motor-filament systems.
Motivated by the cytoskeleton of eukaryotic cells, we develop a general framework for describing the large-scale dynamics of an active filament network. In the cytoskeleton, active cross-links are formed by motor proteins that are able to induce relative motion between filaments. Starting from pair-wise interactions of filaments via such active processes, our framework is based on momentum conservation and an analysis of the momentum flux. This allows us to calculate the stresses in the filament network generated by the action of motor proteins. We derive effective theories for the filament dynamics which can be related to continuum theories of active polar gels. As an example, we discuss the stability of homogenous isotropic filament distributions in two spatial dimensions.
Kruse
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Max-Planck-Institut für Physik komplexer Systeme, Nöthnitzerstr. 38, 01187, Dresden, Germany. karsten@lusi.uni-sb.de
Jülicher
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D001696:Biomechanical Phenomena / Q000379:methods*; D003198:Computer Simulation; D004398:Dyneins / Q000737:chemistry*; D007700:Kinetics; D019563:Mechanics; D008870:Microtubules / Q000737:chemistry*; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry*; D009038:Motion; D009218:Myosins / Q000737:chemistry*; D013314:Stress, Mechanical
D020409:Molecular Motor Proteins; D009218:Myosins; D004398:Dyneins