[Skin necrosis of penis after chemotherapy regimen in patients with resistant nonseminomatous testicular tumor].
The majority of patients with resistant nonseminomatous testicular tumor can be cured with standard chemotherapy based on cisplatin regimen. However, complete remission cannot be achieved in 10%-30% of patients, or the disease recurs after the first chemotherapy cycle, on what account the salvage chemotherapy is administered. The initial BEP chemotherapy was applied in patients with gonadal nonseminomatous tumors B2 clinical stage after the left side inguinal orchiectomy. Due to manifested resistance, further chemotherapy was given according to VIP and one cycle by VEIP regimen. Upon inserting the urinary catheter because of total urinary retention, the phlegmonous inflammation and subsequently the necrosis of preputial and corpus skin of the penis were observed. The necrectomy with autotransplant was performed after demarcation. The skin necrosis of penis is very rare post chemotherapy complication in the stage of evident peripheral pancytopenia that may be the result of toxic effects of the used cytostatics or development of local infection with resulting necrosis.
Stijelja
Borislav
B
Milosević
Radovan
R
Marjanović
Slobodan
S
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects; D008297:Male; D009336:Necrosis; D010413:Penis; D012871:Skin Diseases / Q000139:chemically induced*; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000009:adverse effects
D014747:Vinblastine; D002945:Cisplatin; D007069:Ifosfamide