Characterization of a phenotypically unique population of CD13+ dendritic cells resident in the spleen.
Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a(+) CD11c(+) CD13(+) CD172(+) CD205(+) population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses.
Zhuang
Yan
Y
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, 99164-7040, USA.
Mwangi
Waithaka
W
Brown
Wendy C
WC
Davis
William C
WC
Hope
Jayne C
JC
Palmer
Guy H
GH
D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism; D000938:Antigen-Presenting Cells / Q000276:immunology; D018826:CD13 Antigens / Q000378:metabolism*; D002417:Cattle; D018929:Cell Culture Techniques; D002469:Cell Separation; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000032:analysis / Q000276:immunology; D008297:Male; D010641:Phenotype; D013154:Spleen / Q000166:cytology* / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D007132:Immunoglobulin Isotypes; D018826:CD13 Antigens