title: Heparin binding nanostructures to promote growth of blood vessels.
abstract: Controlling new blood vessel formation is of interest in regenerative medicine and cancer treatment. Heparin, a biopolymer that binds to angiogenic growth factors, was used to nucleate the self-assembly of nanostructures from designed peptide amphiphile molecules. This process yields rigid nanofibers that display heparin chains to orient proteins for cell signaling. In vivo, the nanostructures stimulated extensive new blood vessel formation using nanogram amounts of growth-factor proteins that by themselves did not induce any detectable angiogenesis.
authors.affiliation: Department of Biomedical Engineering, Institute for BioNanotechnology in Medicine, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: Kanya
authors.initials: K
authors.lastname: Rajangam
authors.forename: Heather A
authors.initials: HA
authors.lastname: Behanna
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hui
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Han
authors.forename: James F
authors.initials: JF
authors.lastname: Hulvat
authors.forename: Jon W
authors.initials: JW
authors.lastname: Lomasney
authors.forename: Samuel I
authors.initials: SI
authors.lastname: Stupp
mesh_terms: D042501:Angiogenic Proteins / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D001665:Binding Sites; D006493:Heparin / Q000008:administration & dosage* / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000502:physiology*; D011485:Protein Binding; D051381:Rats; D012171:Retinal Vessels / Q000187:drug effects* / Q000254:growth & development*
chemical_list: D042501:Angiogenic Proteins; D006493:Heparin