Michael addition of pyrimidine with disaccharide acrylates catalyzed in organic medium with lipase M from Mucor javanicus.
The Michael addition of fluorouracil (0.01 mol), uracil (0.01 mol), thymine (0.01 mol) to disaccharide acrylates (0.03 mol) was carried out in pyridine (20 ml) at 50 degrees C for 72 h with lipase M from Mucor javanicus (200 mg). Six new pyrimidine derivatives containing a branched sugar were obtained in yields from 56 to 75%.
Dai
Hong-Xia
HX
Department of Environment Engineering, Daqing Petroleum Institute, Daqing 163318, People's Republic of China. hongxiadai@163.com
Yao
Shi-Ping
SP
Wang
Jian
J
D000179:Acrylates / Q000737:chemistry*; D004187:Disaccharides / Q000737:chemistry*; D005472:Fluorouracil / Q000737:chemistry*; D008049:Lipase / Q000378:metabolism*; D009089:Mucor / Q000201:enzymology; D013941:Thymine / Q000737:chemistry; D014498:Uracil / Q000737:chemistry
D000179:Acrylates; D004187:Disaccharides; D014498:Uracil; D008049:Lipase; D013941:Thymine; D005472:Fluorouracil