The influence of lysophosphatidic acid on the immunophenotypic differentiation of human monocytes into dendritic cells.
Lysophosphatidic acid (LPA), a naturally occurring phospholipid, has been suggested to have an immunoregulatory role. We investigated the effect of LPA on differentiation of human monocytes into dendritic cells (DC). We found that LPA affects DC differentiation from monocytes by blocking the expression of CD1a molecules on their surface in a dose-dependent manner.
Martino
Angelo
A
Volpe
Elisabetta
E
Baldini
Patrizia Morena
PM
D018949:Antigens, CD1; D002454:Cell Differentiation / Q000187:drug effects*; D003713:Dendritic Cells / Q000166:cytology*; D006801:Humans; D016130:Immunophenotyping; D008246:Lysophospholipids / Q000494:pharmacology*; D009000:Monocytes / Q000166:cytology*
D018949:Antigens, CD1; C419393:CD1a antigen; D008246:Lysophospholipids; C032881:lysophosphatidic acid