Dysfunction of paracellin-1 by dephosphorylation in Dahl salt-sensitive hypertensive rats.
A high-salt diet reduced the levels of renal cAMP content and serine-phosphorylated paracellin-1 in Dahl salt-sensitive hypertensive rats. In MDCK cells expressing paracellin-1, protein kinase A inhibitor reduced the serine-phosphorylated paracellin-1 and transepithelial Mg(2+) transport, suggesting that a dephosphorylation of paracellin-1 induces the reduction of Mg(2+) reabsorption in salt-sensitive hypertension.
Ikari
Akira
A
Department of Pharmaco-Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. ikari@u-shizuoka-ken.ac.jp
Matsumoto
Satomi
S
Harada
Hitoshi
H
Takagi
Kuniaki
K
Degawa
Masakuni
M
Takahashi
Tadanobu
T
Sugatani
Junko
J
Miwa
Masao
M
D000818:Animals; D002460:Cell Line; D057167:Claudins; D000242:Cyclic AMP / Q000378:metabolism; D004285:Dogs; D006973:Hypertension / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D020303:Rats, Inbred Dahl
D057167:Claudins; D008565:Membrane Proteins; C502010:claudin 16; D000242:Cyclic AMP; D008274:Magnesium