title: Convenient syntheses of [20,20,20-H(3)]-arachidonic acid and [20,20-H(2)]-20-hydroxyeicosatetraenoic acid.
abstract: Deuterated arachidonic acid and 20-HETE were prepared in good overall yields and high stereoselectivities. Key transformations include a trans-specific vinyl dibromide reduction and Suzuki cross-couplings to a lithium borate or a 9-BBN borane. These standards are three and two mass units higher, respectively, than their naturally occurring counterparts and are useful in mass spectrometry analysis.
authors.forename: J R
authors.initials: JR
authors.lastname: Falck
authors.forename: Siddam
authors.initials: S
authors.lastname: Anjaiah
authors.forename: Venugopal Raju
authors.initials: VR
authors.lastname: Tuniki
authors.forename: V Raj
authors.initials: VR
authors.lastname: Gopal
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Capdevila