title: Field testing of a fenbendazole treatment combined with hygienic and management measures against a natural Giardia infection in calves.
abstract: The need of a combination of animal treatment and environmental measures against a natural Giardia infection in calves between the age of 1 and 6 months was emphasized and evaluated. Ten commercial farms with a total of 94 calves suffering from chronic diarrhea, ill thriving and impaired growth, were included in two subsequent studies. The first study indicated that treatment of all animals with fenbendazole at 15 mg/kg during 3 consecutive days combined with environmental measures on the final day of treatment, which were either removal of bedding, thorough cleaning and ammonia 10% disinfection or relocation of the treated animals to a Giardia free environment, resulted in a total reduction in cyst excretion for at least 2 weeks. In the second study, the immunofluorescence assay (Merifluor Cryptosporidium/Giardia; Meridian Diagnostics Inc., Cincinnati, Ohio) was used quantitatively and confirmed that the combination of treatment and environmental measures resulted in a total reduction of cyst excretion during 2 weeks and in a significant (P<0.05; >or=98.0%) reduction of the cyst excretion until at least 4 weeks after treatment. Furthermore, there was a noticeable improvement of the clinical symptoms in all animals towards day 28 after treatment and 4 months after treatment health in all calves was normal.
authors.affiliation: Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. thomas.geurden@ugent.be
authors.forename: Thomas
authors.initials: T
authors.lastname: Geurden
authors.forename: Jozef
authors.initials: J
authors.lastname: Vercruysse
authors.forename: Edwin
authors.initials: E
authors.lastname: Claerebout
mesh_terms: D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000517:prevention & control*; D004203:Disinfection / Q000379:methods; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000008:administration & dosage / Q000494:pharmacology*; D005872:Giardia / Q000187:drug effects / Q000302:isolation & purification*; D005873:Giardiasis / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D033661:Oocysts
chemical_list: D000969:Antinematodal Agents; D005273:Fenbendazole