Acute effect of Trema micrantha (Ulmaceae) on serum glucose levels in normal and diabetic rats.
Trema micrantha (Ulmaceae) ethanolic crude extract (ECE) was screened for its hypoglycemic activity (250, 500 and 1,000 mg/kg v.o.). The animals were divided in three groups for the evaluation of the hypoglycemic effect: normal rats, rats with alloxan-induced diabetes and hyperglycemic normal rats. The antihyperglycemic activity was compared to the treatment with glibenclamide, an oral hypoglycemic agent. Serum glucose was analyzed after the treatment of the animals. The acute treatment with Trema micrantha ECE (250 and 1,000 mg/kg) caused a significant decrease in the blood glucose levels in diabetic rats, but no effect was observed among the normal treated rats nor the hyperglycemic normal rats. Trema micrantha's leaves are a good candidate for alternative and/or complementary medicine in the management of diabetes mellitus, since they showed beneficial effects on blood glucose levels.
Schoenfelder
Tatiana
T
Departamento de Farmácia, Universidade do Extremo Sul Catarinense, UNESC, Av. Universitária no. 1105, Bairro Universitário, CEP 88806-000, Criciúma SC, Brazil. tas@unesc.net
Cirimbelli
Thayse Marcon
TM
Citadini-Zanette
Vanilde
V
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001938:Brazil; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D034402:Trema
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005905:Glyburide