title: Axonal degeneration with unusual lesions of the myelin in an occupational neuropathy.
abstract: A 35-year-old man had prolonged occupational exposure to lead carboxylate, triethylbenzene, xylene, and dichloromethane, when he developed a subacute predominantly sensory neuropathy. Ultrastructural examination of a peripheral nerve biopsy showed axonal degeneration and unusual lesions of the myelin, with Schwann cell sequestration of vesicular and lamellar debris. Biochemical analysis of lead in a frozen peripheral nerve specimen revealed no significant difference between the propositus and a control. The authors were unable to find any similar peripheral nerve lesions in the literature dealing with neurotoxic chemicals. Any of the several organic solvents could have equally caused the neuropathy and may have been potentialized by the other chemicals.
authors.affiliation: Neuropathology Department and Laboratoire de Neurobiologie des Affections de la Myéline EA2966, Bordeaux 2 University, Bordeaux, France. anne.vital@chu-bordeaux.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Vital
authors.forename: Claude
authors.initials: C
authors.lastname: Vital
authors.forename: Antoine
authors.initials: A
authors.lastname: Arnaud
authors.forename: Christian
authors.initials: C
authors.lastname: Moesch
authors.forename: Alain
authors.initials: A
authors.lastname: Lagueny
mesh_terms: D000328:Adult; D001369:Axons / Q000648:ultrastructure*; D004781:Environmental Exposure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000648:ultrastructure*; D009410:Nerve Degeneration / Q000139:chemically induced / Q000473:pathology*; D009412:Nerve Fibers / Q000648:ultrastructure; D009422:Nervous System Diseases / Q000139:chemically induced / Q000473:pathology*; D009498:Neurotoxins / Q000009:adverse effects; D009784:Occupational Diseases / Q000139:chemically induced / Q000473:pathology*
chemical_list: D009498:Neurotoxins