title: Gastroesophageal reflux disease symptoms on antisecretory therapy: acid, non-acid, or no GERD.
abstract: A clinically important subset of patients with erosive esophagitis will not attain adequate symptom relief and healing on once-a-day proton pump inhibitor therapy. This is especially true in patients with frequent and nocturnal heartburn and in those with Los Angeles Grades C and D erosive esophagitis. The approach to evaluation and management of cases of refractory or difficult gastroesophageal reflux disease is the subject of this state-of-the-art review.
authors.affiliation: Division of Gastroenterology, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
authors.forename: Philip O
authors.initials: PO
authors.lastname: Katz
mesh_terms: D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001471:Barrett Esophagus / Q000188:drug therapy / Q000209:etiology; D004942:Esophagitis, Peptic / Q000188:drug therapy / Q000209:etiology; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D009853:Omeprazole