Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice.
We investigated the anti-tumor effects of a dry powder preparation of the antlered form of Ganoderma lucidum (G. lucidum AF, rokkaku-reishi in Japanese), a variant type of G. lucidum, not only in allogeneic Sarcoma 180-bearing ddY mice, but also in syngeneic MM 46-bearing C3H/He mice. G. lucidum AF inhibited tumor growth and elongated the life span when orally administered to mice by free-feeding of a 2.5% G. lucidum AF-containing diet. It also showed anti-tumor activity in spite of post-feeding after tumor inoculation. G. lucidum AF significantly countered the depression of splenic CD8+ cells and protected the decrease in interferon-gamma (IFN-gamma) production in regional lymph nodes of MM 46-bearing mice, indicating that the anti-tumor activity of G. lucidum AF might be caused by its immunostimulating action. These results suggest that the ingestion of G. lucidum AF can be useful for the prevention and curing of cancer.
Nonaka
Yuji
Y
Institute for Health Care Science, Suntory Ltd., Osaka, Japan. Yuji_Nonaka@suntory.co.jp
Shibata
Hiroshi
H
Nakai
Masaaki
M
Kurihara
Hiroshi
H
Ishibashi
Hiroko
H
Kiso
Yoshinobu
Y
Tanaka
Takaharu
T
Yamaguchi
Hideyo
H
Abe
Shigeru
S
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005434:Flow Cytometry; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D008517:Phytotherapy / Q000379:methods; D020940:Reishi / Q000737:chemistry*; D012510:Sarcoma 180 / Q000188:drug therapy / Q000276:immunology; D016019:Survival Analysis
D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D007519:Isoantigens; D015847:Interleukin-4; D007371:Interferon-gamma