title: Association of the dysbindin gene with bipolar affective disorder.
abstract: OBJECTIVE
  In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study.
  
  
  METHODS
  Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed.
  
  
  RESULTS
  Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study.
  
  
  CONCLUSIONS
  Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.
authors.affiliation: Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, UK.
authors.forename: Gerome
authors.initials: G
authors.lastname: Breen
authors.forename: Diana
authors.initials: D
authors.lastname: Prata
authors.forename: Sarah
authors.initials: S
authors.lastname: Osborne
authors.forename: Janet
authors.initials: J
authors.lastname: Munro
authors.forename: Maggie
authors.initials: M
authors.lastname: Sinclair
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Susan
authors.initials: S
authors.lastname: Staddon
authors.forename: David
authors.initials: D
authors.lastname: Dempster
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sainz
authors.forename: Barbara
authors.initials: B
authors.lastname: Arroyo
authors.forename: Robert W
authors.initials: RW
authors.lastname: Kerwin
authors.forename: David
authors.initials: D
authors.lastname: St Clair
authors.forename: David
authors.initials: D
authors.lastname: Collier
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics
chemical_list: D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005819:Genetic Markers