Effects of caffeine on levodopa pharmacokinetics and pharmacodynamics in Parkinson disease.
The authors studied the acute effect of caffeine on the levodopa pharmacokinetics and pharmacodynamics in 12 patients with idiopathic Parkinson disease. This double-blind, randomized, crossover study revealed that caffeine shortened the maximal plasma concentration of levodopa, decreased the latency to levodopa walking and tapping motor response, and increased the magnitude of walking response. Caffeine administered before levodopa may improve its pharmacokinetics in some parkinsonian patients.
Deleu
D
D
Department of Neurology (Medicine), Sultan Qaboos University Hospital, Sultanate of Oman. doc_deleu@hotmail.com
Jacob
P
P
Chand
P
P
Sarre
S
S
Colwell
A
A
D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002110:Caffeine / Q000008:administration & dosage*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007980:Levodopa / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors
D000978:Antiparkinson Agents; D000697:Central Nervous System Stimulants; D002110:Caffeine; D007980:Levodopa