title: Hemodynamic and oxidative stress profile after exercise in type 2 diabetes.
abstract: This study investigated the effect of an acute bout of exercise (>85% VO2Max) on biochemical, hemodynamic and oxidative stress variables in sedentary and physically active subjects with type 2 diabetes (T2D). Blood measurements were taken before and after a treadmill test on 12 sedentary non-diabetes subjects (ND), 12 sedentary type 2 diabetes (T2S) and 9 physically active T2D subjects (T2DA). T2DS subjects before and after the treadmill test showed a higher plasma glucose (123.2 +/- 19.0 mg/dL versus 108.9 +/- 16.8 mg/dL, p < 0.001), HbA1C (8.7 +/- 2.4% versus 7.3 +/- 1.2%, p < 0.001) and body fat% (21.3 +/- 5.7% versus 34.6 +/- 4.5%, p < 0.001) than T2DA subjects. T2DA had higher VO2Max (37.7 +/- 3.5 versus 29.5 +/- 3.2, p < 0.05), time on treadmill (22.3 +/- 2.1 min versus 16.1 +/- 2.1 min, p < 0.05), hemoglobin (17.9 +/- 0.9 g/dL, p < 0.05) and lower blood pressure levels in comparison to ND and T2DS subjects. Thiobarbituric acid substances (TBARS) in T2DS were higher than in T2DA subjects (0.27 +/- 0.1 nmol/mL versus 0.21 +/- 0.1 nmol/mL, p < 0.05). Glutathione (GSH) levels were similar among the groups. Physically active type 2 diabetes subjects had a more favorable biochemical, hemodynamic and oxidative stress profile than sedentary subjects. The coexistence of a poor cardiopulmonary performance and high oxidative stress environment can determine a profile of high risk for serious cardiovascular events in patients with diabetes.
authors.affiliation: Family and Preventive Medicine, University of California, San Diego, Gilman Drive 9500, La Jolla, CA 92093-0622, United States. lvillaca@ucsd.edu
authors.forename: L
authors.initials: L
authors.lastname: Villa-Caballero
authors.forename: A A
authors.initials: AA
authors.lastname: Nava-Ocampo
authors.forename: A C
authors.initials: AC
authors.lastname: Frati-Munari
authors.forename: S M
authors.initials: SM
authors.lastname: Rodríguez de León
authors.forename: A R
authors.initials: AR
authors.lastname: Becerra-Pérez
authors.forename: R M
authors.initials: RM
authors.lastname: Ceja
authors.forename: M G
authors.initials: MG
authors.lastname: Campos-Lara
authors.forename: H A
authors.initials: HA
authors.lastname: Ponce-Monter
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D003971:Diastole; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012016:Reference Values; D013599:Systole; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D001786:Blood Glucose; D017392:Thiobarbituric Acid Reactive Substances