title: Twenty-three novel HLA-B alleles identified during intermediate-resolution testing.
abstract: Twenty-three novel human leukocyte antigen-B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants are single-nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *1312, *1598, *1599, *3558, *3931, *4107, and *5616) and five with silent substitutions (B*070204, *130202, *270507, *350104, and *510106). Three alleles (B*0738, *4812, and *5520) differ by five nucleotide changes, altering four amino acids. The remaining seven alleles differ from their most similar alleles by two to three nucleotides, altering from one to two amino acids.
authors.affiliation: Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Lazaro
authors.forename: K
authors.initials: K
authors.lastname: Cao
authors.forename: C
authors.initials: C
authors.lastname: Masaberg
authors.forename: N K
authors.initials: NK
authors.lastname: Steiner
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
authors.forename: B
authors.initials: B
authors.lastname: Tu
authors.forename: V
authors.initials: V
authors.lastname: Turner
authors.forename: P
authors.initials: P
authors.lastname: Nickerson
authors.forename: S
authors.initials: S
authors.lastname: Stoll
authors.forename: C
authors.initials: C
authors.lastname: Schall
authors.forename: R
authors.initials: R
authors.lastname: Valdez
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: R J
authors.initials: RJ
authors.lastname: Hartzman
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D000483:Alleles; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D009154:Mutation
chemical_list: D015235:HLA-B Antigens