title: Double trouble (McArdle's disease and myasthenia gravis): how can exercise help?
abstract: We report a 29-year-old patient with McArdle's disease and myasthenia gravis. She had been debilitated with McArdle's disease since childhood (with marked rhabdomyolysis) and was obese. Myasthenia gravis was diagnosed at 24 years of age. After 3 months of aerobic exercise training, her exercise capacity increased significantly and she regained the ability to live independently. We conclude that even patients with profound neuromuscular diseases may benefit from carefully prescribed exercise training.
authors.affiliation: Universidad Europea de Madrid, 28670 Madrid, Spain. alejandro.lucia@uem.es
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
authors.forename: José L
authors.initials: JL
authors.lastname: Maté-Muñoz
authors.forename: Margarita
authors.initials: M
authors.lastname: Pérez
authors.forename: Carl
authors.initials: C
authors.lastname: Foster
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gutiérrez-Rivas
authors.forename: Joaquín
authors.initials: J
authors.lastname: Arenas
mesh_terms: D000328:Adult; D049108:Cell Enlargement; D003402:Creatine Kinase / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D024982:Glycogen Phosphorylase, Muscle Form / Q000172:deficiency; D006012:Glycogen Storage Disease Type V / Q000150:complications* / Q000503:physiopathology / Q000534:rehabilitation*; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000378:metabolism; D018482:Muscle, Skeletal / Q000294:innervation / Q000378:metabolism / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000150:complications* / Q000503:physiopathology / Q000534:rehabilitation*; D009469:Neuromuscular Junction / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D019344:Lactic Acid; D024982:Glycogen Phosphorylase, Muscle Form; D003402:Creatine Kinase