title: Ductal carcinoma in situ: value of sentinel lymph node biopsy.
abstract: BACKGROUND
  Ductal carcinoma in situ (DCIS) represents about 20% of newly diagnosed breast carcinomas. Axillary metastasis is often related to undiagnosed DCIS with microinvasion (DCISM). The aim of this study was to confirm the interest of sentinel lymph node (SLN) biopsy in extensive DCIS.
  
  
  METHODS
  Patients with a diagnosis of DCIS or DCISM and axillary lymph node evaluation were selected. Surgical treatment included SLN biopsy and/or axillary lymph node dissection (ALND). Serial sections were stained with hematoxylin and eosin (H&E) and with an immunohistochemical (IHC) method. When a micrometastasis was found, the breast specimen was revised searching for occult microinvasion.
  
  
  RESULTS
  Hundred and forty patients with initial DCIS were enrolled in the study. Node metastasis was identified in 9 patients (7%) of the 128 patients with DCIS and DCISM. At final histology, 4 (10%) of the 39 patients with pure DCIS and SLN biopsy and 1 (7%) of the 14 patients with DCISM and SLN biopsy had axillary micrometastasis. Four of the 12 patients upstaged to invasive carcinoma had metastatic SLNs.
  
  
  CONCLUSIONS
  Sentinel lymph node biopsy is valuable in patients with diffuse DCIS or DCISM who are scheduled for mastectomy in order to search for axillary micrometastases and occult breast microinvasion.
authors.affiliation: Department of Gynecology, Hôpital Tenon, Paris, France. rita.sakr@tnn.aphp.fr
authors.forename: Rita
authors.initials: R
authors.lastname: Sakr
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Barranger
authors.forename: Martine
authors.initials: M
authors.lastname: Antoine
authors.forename: Herve
authors.initials: H
authors.lastname: Prugnolle
authors.forename: Emile
authors.initials: E
authors.lastname: Daraï
authors.forename: Serge
authors.initials: S
authors.lastname: Uzan
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008408:Mastectomy; D015412:Mastectomy, Segmental; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy / Q000592:standards*