title: Developmental dissociation, deviance, and delay: Occurrence of attention-deficit-hyperactivity disorder in individuals with and without borderline-to-mild intellectual disability.
abstract: A neurodevelopmental model for understanding the spectrum of developmental disabilities postulates that developmental delay, dissociation, and deviance reflect underlying central nervous system dysfunction. In this study, we determined the occurrence of the dissociated and developmentally deviant behavioral profile of attention-deficit-hyperactivity disorder (ADHD) among children with and without developmental cognitive delays (borderline-to-mild intellectual disability) in a population-based birth cohort (n = 5718). Among the 70 children identified to have borderline-to-mild intellectual disability, 30% (n = 21; 7 females, 14 males) met research criteria for ADHD, compared to only 6.4% of children without intellectual disability (n = 358; 88 females, 270 males). The odds ratio for comorbid ADHD for children with versus without borderline-to-mild intellectual disability was 6.3 (95% confidence interval: 3.7-10.6; p < 0.001). These data illustrate that developmental dissociation and/or deviance, as represented by ADHD, are more likely to occur in the context of developmental delay, represented by borderline-to-mild intellectual disability.
authors.affiliation: Division of Developmental and Behavioral Pediatrics, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA. voigt.robert@mayo.edu
authors.forename: Robert G
authors.initials: RG
authors.lastname: Voigt
authors.forename: William J
authors.initials: WJ
authors.lastname: Barbaresi
authors.forename: Robert C
authors.initials: RC
authors.lastname: Colligan
authors.forename: Amy L
authors.initials: AL
authors.lastname: Weaver
authors.forename: Slavica K
authors.initials: SK
authors.lastname: Katusic
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications*; D002648:Child; D019955:Conduct Disorder / Q000150:complications*; D016001:Confidence Intervals; D002658:Developmental Disabilities / Q000150:complications*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004213:Dissociative Disorders / Q000150:complications*; D005260:Female; D006801:Humans; D007360:Intelligence; D007859:Learning Disabilities; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D016017:Odds Ratio; D014888:Wechsler Scales / Q000706:statistics & numerical data