Mycobacterium tuberculosis complex and mycobacterial heat shock proteins in lymph node tissue from patients with pulmonary sarcoidosis.
We demonstrated that not whole Mycobacterium tuberculosis but its particular antigens, hsp70(Mtb), hsp65(Mtb), and hsp16(Mtb), are present in lymph node tissues of patients with sarcoidosis (SA). hsp16(Mtb) occurs in the early stage of SA, whereas hsp70(Mtb) occurs in stage II of SA. hsp65(Mtb) is highly expressed in the capillary vessels in lymph node tissues in patients with SA.
Dubaniewicz
Anna
A
Department of Pathophysiology, Medical University of Gdansk, Debinki 7 str., 80-211 Gdansk, Poland. aduban@amg.gda.pl
Dubaniewicz-Wybieralska
Miroslawa
M
Sternau
Adam
A
Zwolska
Zofia
Z
Izycka-Swieszewska
Ewa
E
Augustynowicz-Kopec
Ewa
E
Skokowski
Jaroslaw
J
Singh
Mahavir
M
Zimnoch
Lech
L
D001426:Bacterial Proteins / Q000378:metabolism*; D018834:Chaperonin 60; D018833:Chaperonins / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000378:metabolism / Q000472:pathogenicity*; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis* / Q000382:microbiology; D014376:Tuberculosis / Q000175:diagnosis* / Q000382:microbiology
D001426:Bacterial Proteins; D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins; C444642:HSP70 protein, Mycobacterium tuberculosis; D006360:Heat-Shock Proteins; C113725:HspA protein, bacteria; C074119:heat-shock protein 65, Mycobacterium; D018833:Chaperonins