title: Effect of radioactivity on stent-graft incorporation after endovascular treatment of aneurysms: An animal study.
abstract: Poor stent-graft (SG) incorporation into the vessel wall, following endovascular repair of abdominal aortic aneurysms (EVAR), can lead to endoleaks and SG migration. Low-dose radiation can prevent aneurysm recurrence after coil embolization, and has been associated with a "paradoxical" increase in neointima formation after stenting in a few studies. It was hypothesized that in situ beta radiation emitted from SG could improve its incorporation by preventing the persistence of circulating channels between the implant and the vessel wall and increasing neointima formation around the SG. Phosphorus 32 ((32)P, 200 or 400 kBq per SG (n = 6 each)) was ion implanted on the external surface of balloon-expandable SGs. Twelve radioactive and six non-radioactive SGs were deployed in iliac arteries of nine Mongrel dogs. Neointima formation inside the graft and the persistence of circulating flow through an artificial groove created during the endovascular procedure were assessed by follow-up imaging and by blinded, computerized histomorphometric analysis after animal sacrifice at 3 months. Occlusion occurred in four radioactive SGs. A lesser number of patent grooves was observed along high-activity SGs than along control SGs (1/3 versus 4/4). No difference in neointima formation was observed in radioactive and non-radioactive SGs. Alteration of external graft surface was observed after ion implantation. Ion implantation of (32)P on SGs does not seem to be a viable strategy to improve incorporation and prevent type-I endoleak after EVAR.
authors.affiliation: Laboratory of Endovascular Biomaterials, Research Center, University of Montreal Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada. sophie.lerouge@umontreal.ca
authors.forename: Sophie
authors.initials: S
authors.lastname: Lerouge
authors.forename: Jean
authors.initials: J
authors.lastname: Raymond
authors.forename: Klaus
authors.initials: K
authors.lastname: Schloesser
authors.forename: Louis
authors.initials: L
authors.lastname: Gaboury
authors.forename: Gilles
authors.initials: G
authors.lastname: Soulez
mesh_terms: D000783:Aneurysm / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D008855:Microscopy, Electron, Scanning; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use; D015607:Stents; D015996:Survival Rate
chemical_list: D010761:Phosphorus Radioisotopes