title: DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.
abstract: We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).
authors.affiliation: Istituti di Ematologia, Universita' Cattolica Sacro Cuore, Rome. mtvoso@rm.unicatt
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Voso
authors.forename: Daniela
authors.initials: D
authors.lastname: Gumiero
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Alo'
authors.forename: Francesco
authors.initials: F
authors.lastname: Guidi
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mansueto
authors.forename: Anna Laura
authors.initials: AL
authors.lastname: Di Febo
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Massini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Martini
authors.forename: Luigi Maria
authors.initials: LM
authors.lastname: Larocca
authors.forename: Stefan
authors.initials: S
authors.lastname: Hohaus
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Leone
mesh_terms: D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000032:analysis / Q000235:genetics*; D014408:Biomarkers, Tumor; D001853:Bone Marrow / Q000201:enzymology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000032:analysis / Q000235:genetics*; D019175:DNA Methylation; D064550:Death-Associated Protein Kinases; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases