title: Surfactant therapy for patients with ARDS after cardiac surgery.
abstract: This multicenter study investigated the possibility of reducing mortality rate by administering natural lung surfactant additional to standard therapy to treat patients after cardiac surgery who developed an acute respiratory failure (ARDS/ALI).A total of 78 patients (1998-2002) diagnosed with ALI or ARDS were enrolled in the study; patients were considered for study entry only if they developed ALI/ARDS within 72 h after cardiac surgery. A total of 36 patients (2000-2002) received Surfactant-BL via bronchoscope at a dose of 3 mg/kg twice a day, and 42 patients (1998-2000) served as the historical control. Within 24 h after the first Surfactant-BL administration the PaO2/FiO2 ratio increased from (mean+/-SEM) 129.7+/-9.9 mm Hg to 187.6+/-17.6 mm Hg (p<0.01), FiO2 decreased from (mean+/-SEM) 0.71+/-0.03 to 0.56+/-0.03 (p<0.01), and 69.4% of the patients treated with surfactant were weaned from the ventilator compared with 50% of the control group during a 28-day period. The mortality rate among patients treated with Surfactant-BL was 30.6% compared with 50% in the control group. In conclusion, early administration of Surfactant-BL leads to the reduction of mortality in cardiac patients who develop postoperatively an ALI or ARDS.
authors.affiliation: Cardiovascular-surgery Clinic of the Military Medical Academy, Saint-Petersburg, Russia.
authors.forename: Andrey
authors.initials: A
authors.lastname: Bautin
authors.forename: Genady
authors.initials: G
authors.lastname: Khubulava
authors.forename: Igor
authors.initials: I
authors.lastname: Kozlov
authors.forename: Vitally
authors.initials: V
authors.lastname: Poptzov
authors.forename: Victor
authors.initials: V
authors.lastname: Osovskikh
authors.forename: Andrey
authors.initials: A
authors.lastname: Seiliev
authors.forename: Vladimir
authors.initials: V
authors.lastname: Volchkov
authors.forename: Oleg
authors.initials: O
authors.lastname: Rosenberg
mesh_terms: D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy*
chemical_list: D011663:Pulmonary Surfactants