title: Salicylic acid permeation: a comparative study with different vehicles and membranes.
abstract: Considering the skin's function, different dermal pharmaceutical forms can be developed according to the type of therapeutic activity, active principle and excipients involved in the formulation, such as "transdermal preparations". In the present study, the permeation parameters of the non-steroidal anti-inflammatory drug, salicylic acid (SA) through synthetic membrane, polyvinyliden difluoride, and a biological membrane, egg shell membrane, with different vehicles, propylene glycol, isopropyl alcohol and carbopol gel, were determined. The reported physicochemical parameters of SA from CG were significantly higher than those obtained using PG and IP. This is attributed to the lipophilic nature of the vehicle that facilitates the release and penetration of the active principle, thus acting sinergically. The permeation profiles of SA allow us to state that permeation kinetics is of first order, so that the flux values obtained are in direct proportion to the specific rates of drug release.
authors.affiliation: Proyecto 9101- Area de Química Física, Dpto. de Química, Universidad Nacional de San Luis, Chacabuco y Pedernera, (5700) San Luis, Argentina. olivella@unsl.edu.ar
authors.forename: Mónica S
authors.initials: MS
authors.lastname: Olivella
authors.forename: Nora B
authors.initials: NB
authors.lastname: Debattista
authors.forename: Nora B
authors.initials: NB
authors.lastname: Pappano
mesh_terms: D019840:2-Propanol / Q000008:administration & dosage; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics; D002462:Cell Membrane / Q000378:metabolism*; D004528:Egg Shell / Q000378:metabolism*; D010539:Permeability; D019946:Propylene Glycol / Q000008:administration & dosage; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019946:Propylene Glycol; D019840:2-Propanol; D020156:Salicylic Acid