title: Bile-induced curing of the virulence plasmid in Salmonella enterica serovar Typhimurium.
abstract: Exposure to bile induces curing of the virulence plasmid in Salmonella enterica serovar Typhimurium (pSLT). Disruption of the ccdB gene increases pSLT curing, both spontaneous and induced by bile, suggesting that the pSLT ccdAB genes may encode a homolog of the CcdAB addiction module previously described in the F sex factor. Unlike the F sex factor, synthesis of pSLT-encoded pili does not confer bile sensitivity. These observations may provide insights into the evolution of virulence plasmids in Salmonella subspecies I, as well as the causes of virulence plasmid loss in other Salmonella subspecies.
authors.affiliation: Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, E-41080 Seville, Spain.
authors.forename: Meritxell
authors.initials: M
authors.lastname: García-Quintanilla
authors.forename: Ana I
authors.initials: AI
authors.lastname: Prieto
authors.forename: Laurent
authors.initials: L
authors.lastname: Barnes
authors.forename: Francisco
authors.initials: F
authors.lastname: Ramos-Morales
authors.forename: Josep
authors.initials: J
authors.lastname: Casadesús
mesh_terms: D029681:Arabidopsis Proteins; D001426:Bacterial Proteins / Q000502:physiology; D001646:Bile; D004260:DNA Repair; D004269:DNA, Bacterial / Q000235:genetics; D017353:Gene Deletion; D008565:Membrane Proteins; D010957:Plasmids / Q000235:genetics*; D012486:Salmonella typhimurium / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D029681:Arabidopsis Proteins; D001426:Bacterial Proteins; C489148:CcdA protein, Arabidopsis; D004269:DNA, Bacterial; D008565:Membrane Proteins