title: Plasma adrenomedullin levels in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate adrenomedullin levels in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Department of obstetrics and gynecology in a university hospital.
  
  
  METHODS
  Thirty-eight women with PCOS and 29 healthy control subjects were enrolled in the study.
  
  
  METHODS
  Plasma adrenomedullin, serum androstenedione, free T, T, DHEAS, SHBG, thyrotropin, PRL, FSH, LH, and E2 were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose:insulin ratio and 75-g glucose tolerance test for 2 hours.
  
  
  METHODS
  Plasma adrenomedullin levels and correlations among adrenomedullin and gonadotropins, female sex steroids, androgens, and insulin resistance.
  
  
  RESULTS
  There was no significant difference concerning plasma adrenomedullin concentrations between the groups. In patients with PCOS, fasting glucose, fasting insulin, body mass index, and free T were inversely correlated with the plasma adrenomedullin. Plasma adrenomedullin was significantly correlated with glucose:insulin ratio. After controlling for body mass index, there were no significant correlations between the above-mentioned parameters.
  
  
  CONCLUSIONS
  Adrenomedullin may play a role in regulating the insulin metabolism in patients with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Kirikkale University School of Medicine, Kirikkale, Turkey. banuucar@gmail.com
authors.forename: Banu
authors.initials: B
authors.lastname: Ucar
authors.forename: Volkan
authors.initials: V
authors.lastname: Noyan
authors.forename: Osman
authors.initials: O
authors.lastname: Caglayan
authors.forename: Aykan
authors.initials: A
authors.lastname: Yucel
authors.forename: Nevin
authors.initials: N
authors.lastname: Sagsoz
mesh_terms: D000293:Adolescent; D053607:Adrenomedullin; D000328:Adult; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007333:Insulin Resistance; D010455:Peptides / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013223:Statistics as Topic
chemical_list: D010455:Peptides; D053607:Adrenomedullin