Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents.
The syntheses and anti-tuberculosis activity of quinolone-cephalosporin conjugates (1 and 2) are described. Both showed broad-spectrum antibacterial activity and significant anti-TB activity. The carbamate-linked quinolone-cephem 2 showed better antimycobacterial activity, including anti-TB activity, than the direct amine-linked quinolone-cephem 1, while quinolone-cephem 1 was slightly more effective against some Gram-negative bacterial strains.
Zhao
Gaiying
G
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Miller
Marvin J
MJ
Franzblau
Scott
S
Wan
Baojie
B
Möllmann
Ute
U
D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002511:Cephalosporins / Q000138:chemical synthesis / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D015363:Quinolones / Q000138:chemical synthesis / Q000494:pharmacology*
D000995:Antitubercular Agents; D002511:Cephalosporins; D015363:Quinolones