title: Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies.
abstract: BACKGROUND
  The revolution in molecular biology that has taken place over the past 2 decades has provided researchers with new and powerful tools for detailed study of the molecular mechanisms giving rise to the spectrum of pediatric brain tumors. Application of these tools has greatly advanced our understanding of the molecular pathogenesis of these lesions.
  
  
  METHODS
  After familiarizing readers with some promising new techniques in the field of oncogenomics, this review will present the current state of knowledge as it pertains to the molecular biology of pediatric brain neoplasms. Along the way, we hope to highlight specific instances where the detailed mechanistic knowledge acquired thus far may be exploited for therapeutic advantage.
authors.affiliation: Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Tamber
authors.forename: Krishan
authors.initials: K
authors.lastname: Bansal
authors.forename: Muh-Lii
authors.initials: ML
authors.lastname: Liang
authors.forename: Todd G
authors.initials: TG
authors.lastname: Mainprize
authors.forename: Bodour
authors.initials: B
authors.lastname: Salhia
authors.forename: Paul
authors.initials: P
authors.lastname: Northcott
authors.forename: Michael
authors.initials: M
authors.lastname: Taylor
authors.forename: James T
authors.initials: JT
authors.lastname: Rutka
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics* / Q000628:therapy; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D010372:Pediatrics