title: Chondroid syringoma: case report and review of the literature.
abstract: An 84-year-old man presented with an enlarging bluish, painless subcutaneous nodule on the glabella. The lesion had been excised 4 years prior and was diagnosed as chondroid syringoma, but had gradually regrown. The recurrent lesion was treated by surgical re-excision. Histopathological examination was again consistent with chondroid syringoma, and showed the following: 1) a chondroid matrix, 2) tubuloalveolar structures lined by a double epithelium, 3) ductal structures lined by a single epithelium, 4) nests of polygonal cells, and 5) the presence of keratinous cysts. Chondroid syringoma is a rare mixed tumor of the skin that was first described by Hirsch and Helwig. Characteristically, it is composed of a proliferation of epithelial cells set in a myxoid and chondroid matrix. Although chondroid syringomas are predominantly benign, malignant forms have been reported.
authors.affiliation: University of California Davis, Department of Dermatology, USA.
authors.forename: Raja
authors.initials: R
authors.lastname: Sivamani
authors.forename: Akhil
authors.initials: A
authors.lastname: Wadhera
authors.forename: Errol
authors.initials: E
authors.lastname: Craig
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000369:Aged, 80 and over; D005153:Facial Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology*