title: Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia.
abstract: The functional promoter polymorphism -116C/G of the X-box binding protein 1 (XBP1) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case-control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 -116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.
authors.affiliation: Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Naoki
authors.initials: N
authors.lastname: Fukui
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Muratake
authors.forename: Hideki
authors.initials: H
authors.lastname: Amagane
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kaneko
authors.forename: Ayako
authors.initials: A
authors.lastname: Nunokawa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D000071701:Regulatory Factor X Transcription Factors; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human