FLT3/D835 mutation and inversion of chromosome 16 in leukemic transformation of myelofibrosis.
We present an atypical case of myelofibrosis developing into secondary leukemia FAB subtype M4, with inversion of chromosome 16, FLT3/D835 point mutation and diffuse osteolytic lesions accompanied by elevated TNF-alpha. The simultaneous occurrence of these mutations reflects the progressive association of genetic lesions developing into secondary leukemia with a relatively benign course.
Colovic
Milica
M
Institute of Hematology, University Clinical Center, Belgrade, Serbia.
Jurisic
Vladimir
V
Pavlovic
Sonja
S
Terzic
Tatjana
T
Colovic
Natasa
N