title: Peripheral neurological disturbances, autonomic dysfunction, and antineuronal antibodies in adult celiac disease before and after a gluten-free diet.
abstract: Thirty-two consecutive adult celiac disease (CD) patients (pts), complaining of peripheral neuropathy (12 pts), autonomic dysfunction (17 pts), or both (3 pts), were evaluated to assess the presence of neurological damage (by clinical neurological evaluation and electrophysiological study) and antineuronal antibodies and to assess the effect of a gluten-free diet (GFD) on the course of the neurological symptoms and on antineuronal antibodies. At entry, 12 of 32 (38%) pts showed signs and symptoms of neurological damage: 7 of 12 (58%), peripheral neurological damage; 3 of 12 (25%), autonomic dysfunction; and 2 (17%), both peripheral neurological damage and autonomic dysfunction. The overall TNS score was 105 at entry. Anti-GM1 antibodies were present in 5 of 12 (42%) pts: 3 showed peripheral neurological damage and 2 showed both peripheral neurological damage and autonomic dysfunction. One year after the GFD was started, histological lesions were still present in only 10 of 12 (83%) pts. TNS score was 99, 98, 98, and 101 at the 3rd, 6th, 9th, and 12th month after the GFD was started, so it did not improve throughout the follow-up. None of the pts showed disappearance of antineuronal antibodies throughout the follow-up. We conclude that adult CD patients may show neurological damage and presence of antineuronal antibodies. Unfortunately, these findings do not disappear with a GFD.
authors.affiliation: Digestive Endoscopy Unit, Lorenzo Bonomo Hospital, Andria, (BA), Italy. antotursi@tiscali.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Tursi
authors.forename: Gian Marco
authors.initials: GM
authors.lastname: Giorgetti
authors.forename: Cesare
authors.initials: C
authors.lastname: Iani
authors.forename: Flavio
authors.initials: F
authors.lastname: Arciprete
authors.forename: Giovanni
authors.initials: G
authors.lastname: Brandimarte
authors.forename: Ambrogio
authors.initials: A
authors.lastname: Capria
authors.forename: Luigi
authors.initials: L
authors.lastname: Fontana
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D001342:Autonomic Nervous System Diseases / Q000097:blood / Q000209:etiology*; D002446:Celiac Disease / Q000097:blood* / Q000150:complications* / Q000178:diet therapy; D015331:Cohort Studies; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D005903:Gliadin / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000209:etiology*
chemical_list: D000906:Antibodies; D005732:Gangliosides; D005677:G(M1) Ganglioside; C039129:GQ1b ganglioside; D005903:Gliadin