title: Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.
abstract: The complete genome of Aeromonas hydrophila ATCC 7966(T) was sequenced. Aeromonas, a ubiquitous waterborne bacterium, has been placed by the Environmental Protection Agency on the Contaminant Candidate List because of its potential to cause human disease. The 4.7-Mb genome of this emerging pathogen shows a physiologically adroit organism with broad metabolic capabilities and considerable virulence potential. A large array of virulence genes, including some identified in clinical isolates of Aeromonas spp. or Vibrio spp., may confer upon this organism the ability to infect a wide range of hosts. However, two recognized virulence markers, a type III secretion system and a lateral flagellum, that are reported in other A. hydrophila strains are not identified in the sequenced isolate, ATCC 7966(T). Given the ubiquity and free-living lifestyle of this organism, there is relatively little evidence of fluidity in terms of mobile elements in the genome of this particular strain. Notable aspects of the metabolic repertoire of A. hydrophila include dissimilatory sulfate reduction and resistance mechanisms (such as thiopurine reductase, arsenate reductase, and phosphonate degradation enzymes) against toxic compounds encountered in polluted waters. These enzymes may have bioremediative as well as industrial potential. Thus, the A. hydrophila genome sequence provides valuable insights into its ability to flourish in both aquatic and host environments.
authors.affiliation: The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850,USA. rseshadri@venterinstitute.org
authors.forename: Rekha
authors.initials: R
authors.lastname: Seshadri
authors.forename: Sam W
authors.initials: SW
authors.lastname: Joseph
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Chopra
authors.forename: Jian
authors.initials: J
authors.lastname: Sha
authors.forename: Jonathan
authors.initials: J
authors.lastname: Shaw
authors.forename: Joerg
authors.initials: J
authors.lastname: Graf
authors.forename: Daniel
authors.initials: D
authors.lastname: Haft
authors.forename: Martin
authors.initials: M
authors.lastname: Wu
authors.forename: Qinghu
authors.initials: Q
authors.lastname: Ren
authors.forename: M J
authors.initials: MJ
authors.lastname: Rosovitz
authors.forename: Ramana
authors.initials: R
authors.lastname: Madupu
authors.forename: Luke
authors.initials: L
authors.lastname: Tallon
authors.forename: Mary
authors.initials: M
authors.lastname: Kim
authors.forename: Shaohua
authors.initials: S
authors.lastname: Jin
authors.forename: Hue
authors.initials: H
authors.lastname: Vuong
authors.forename: O Colin
authors.initials: OC
authors.lastname: Stine
authors.forename: Afsar
authors.initials: A
authors.lastname: Ali
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Horneman
authors.forename: John F
authors.initials: JF
authors.lastname: Heidelberg
mesh_terms: D016980:Aeromonas hydrophila / Q000737:chemistry / Q000201:enzymology / Q000235:genetics*; D001149:Arsenates / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics; D010861:Fimbriae, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D011720:Pyrazoles / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics
chemical_list: D001149:Arsenates; D001426:Bacterial Proteins; D002352:Carrier Proteins; D011720:Pyrazoles; D013431:Sulfates; D037521:Virulence Factors; C002626:thiopyrine; D010088:Oxidoreductases; C025657:arsenic acid