title: Late-onset Tay-Sachs disease: adverse effects of medications and implications for treatment.
abstract: The authors conducted a retrospective and brief prospective study of adverse effects of approximately 350 medications in 44 adults with late-onset Tay-Sachs disease (LOTS). Some medications were relatively safe, whereas others, particularly haloperidol, risperidone, and chlorpromazine, were associated with neurologic worsening.
authors.affiliation: Neuromuscular Division, Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106-5098, USA. bes002@aol.com
authors.forename: B E
authors.initials: BE
authors.lastname: Shapiro
authors.forename: S
authors.initials: S
authors.lastname: Hatters-Friedman
authors.forename: J A
authors.initials: JA
authors.lastname: Fernandes-Filho
authors.forename: K
authors.initials: K
authors.lastname: Anthony
authors.forename: M R
authors.initials: MR
authors.lastname: Natowicz
mesh_terms: D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D018450:Disease Progression; D004565:Electroconvulsive Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012189:Retrospective Studies; D013661:Tay-Sachs Disease / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D018712:Analgesics, Non-Narcotic; D011619:Psychotropic Drugs