title: CTX-M-37 in Salmonella enterica serotype Isangi from Durban, South Africa.
abstract: Beta-lactamase-mediated resistance was investigated in 59 putative extended-spectrum beta-lactamase (ESBL)-positive Salmonella spp. from the paediatric ward of a tertiary hospital in Durban, South Africa. Three Salmonella enterica serotype Isangi cultured from stool samples were multidrug resistant, with susceptibility only to meropenem, piperacillin/tazobactam and cefoxitin. Isoelectric focusing revealed beta-lactamases with isoelectric points of pI 5.8, 6.8 and 7.2. Sequencing identified beta-lactamases CTX-M-37 and TEM-1. To our knowledge, this is the first report of CTX-M-37 from S. enterica serotype Isangi in South Africa.
authors.affiliation: School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4000, South Africa. Govindenu@ukzn.ac.za
authors.forename: U
authors.initials: U
authors.lastname: Govinden
authors.forename: C
authors.initials: C
authors.lastname: Mocktar
authors.forename: P
authors.initials: P
authors.lastname: Moodley
authors.forename: A W
authors.initials: AW
authors.lastname: Sturm
authors.forename: S Y
authors.initials: SY
authors.lastname: Essack
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D018432:Drug Resistance, Multiple; D006801:Humans; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D012480:Salmonella Infections / Q000453:epidemiology / Q000382:microbiology*; D019779:Salmonella enterica / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D013019:South Africa / Q000453:epidemiology; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D001618:beta-Lactamases; C515946:beta-lactamase CTX-M-37, Salmonella enterica