title: Diverse 2-carboxamide-3-amino-substituted quinoxalines: synthesis and reactivity investigation for library generation.
abstract: Described herein is the development of a robust synthetic route applicable to parallel synthesis of diverse 2-carboxamide-3-amino-substituted quinoxalines. In addition to the scope and limitations of the methods developed, a purification strategy employing solid-phase extraction (SPE) and application of the methods to a small parallel array of compounds are discussed.
authors.affiliation: Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road/P.O. Box 368, Ridgefield, Connecticut 06877, USA. jkowalsk@rdg.boehringer-ingelheim.com
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Kowalski
authors.forename: Scott F
authors.initials: SF
authors.lastname: Leonard
authors.forename: George E
authors.initials: GE
authors.lastname: Lee
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011804:Quinolines