[CAG repeats of DNA polymerase gamma in Chinese males and relationship of idiopathic male infertility to CAG repeats].
OBJECTIVE
To analyze the polymerase gamma(Polg) gene polymorphisms in Chinese idiopathic infertile males and evaluate the correlation of the polymorphisms with male infertility.


METHODS
We conducted a study of Polg CAG repeats in the sperm or blood DNA of 55 asthenospermia patients, 57 oligospermia patients, 34 azoospermia patients, and 104 controls with PCR and GeneScan. Phenotypic data were available in all the subjects, including semen parameters, and clinical profiles.


RESULTS
The frequency of 10/not 10 CAG genotype in asthenospermia patients was higher than in the other groups, but with no significance.


CONCLUSIONS
Our findings have shown for the first time that there exits an ethnic difference between Chinese and European males in the number of CAG repeats of Polg gene, and that 10/not 10 CAG genotype may affect sperm motility.
Yao
Nan
N
Department of Medical Genetics, Peking Union Medical College, Beijing 100730, China.
Zheng
Jun-Feng
JF
Peng
Yi-Feng
YF
Li
Zuo-Xiang
ZX
Peng
Zuo-Qi
ZQ
Jin
Xiao-Hua
XH
Ma
Xu
X
D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D018911:Trinucleotide Repeats
D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase