title: Outcomes of subsequent pregnancy after first pregnancy with early-onset preeclampsia.
abstract: OBJECTIVE
  The aim of this study was to report outcome of subsequent pregnancy after early-onset preeclampsia in first pregnancy, and to evaluate potential risk factors for recurrence of preeclampsia and preterm delivery.
  
  
  METHODS
  Reproductive follow-up data were obtained for women with a history of early-onset preeclampsia, resulting in delivery before 34 weeks of gestation at the University Medical Center Utrecht, The Netherlands, between July 1993 and September 2002. The relative contributions of demographic data, outcome variables of first pregnancy, and common thrombophilias to the recurrence risk of preeclampsia and preterm delivery in subsequent pregnancy, were estimated by Cox proportional hazard models.
  
  
  RESULTS
  Subsequent pregnancy outcome data were available for 120 women. Overall, preeclampsia reoccurred in the second pregnancy in 30 women (25%). However, 6 women delivered before 34 weeks of gestation (5%), 20 women between 34 and 37 weeks of gestation (17%), and 94 women after 37 weeks of gestation (78%). Forty-one women (34%) had an uneventful pregnancy. Recurrence rates for preeclampsia or preterm delivery were not related to severity of first pregnancy complications, including delivery before 28 weeks of gestation, occurrence of hemolysis, elevated liver enzymes, and low platelet count syndrome, small-for-gestational age infants, and to hereditary or acquired thrombophilias. Chronic hypertension was related to a higher recurrence risk of preeclampsia in the second pregnancy (hazard ratio 2.1, 95% CI 1.0-4.4), and smoking was related to a higher recurrence risk of preterm birth (hazard ratio 2.4, 95% CI 1.1-5.6).
  
  
  CONCLUSIONS
  Outcomes of subsequent pregnancy after first pregnancy with early-onset preeclampsia is generally favorable.
authors.affiliation: Division of Perinatology and Gynecology, University Medical Center Utrecht, The Netherlands.
authors.forename: Bas B
authors.initials: BB
authors.lastname: van Rijn
authors.forename: Lette B
authors.initials: LB
authors.lastname: Hoeks
authors.forename: Michiel L
authors.initials: ML
authors.lastname: Bots
authors.forename: Arie
authors.initials: A
authors.lastname: Franx
authors.forename: Hein W
authors.initials: HW
authors.lastname: Bruinse
mesh_terms: D000328:Adult; D005260:Female; D017359:HELLP Syndrome / Q000453:epidemiology; D006801:Humans; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D016016:Proportional Hazards Models; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D019851:Thrombophilia / Q000453:epidemiology