title: Increased soluble 4-1BB ligand (4-1BBL) levels in peripheral blood of patients with multiple sclerosis.
abstract: 4-1BB ligand (4-1BBL; CD137L) is a member of the tumour necrosis factor superfamily expressed primarily on antigen presenting cells such as B cells, macrophages and dendritic cells. Its engagement with the receptor 4-1BB (CD137) has been shown to promote T-cell activation and regulate proliferation and survival of T cells. The role of the costimulatory molecule in multiple sclerosis (MS) remains unclear. In this study, the expression of 4-1BBL and soluble 4-1BBL (s4-1BBL) protein levels were analysed in peripheral blood of MS patients. Compared with healthy controls, MS patients had an increase in both plasma s4-1BBL protein levels and expression of 4-1BBL in CD14(+) monocytes. In contrast, myelin basic protein-reactive T-cell proliferation was not found to be inhibited by the use of an anti-4-1BBL antibody. The elevated s4-1BBL protein levels in the MS patients may function as a self-regulatory mechanism of 4-1BB/4-1BBL interaction and costimulation.
authors.affiliation: Department of Neurology, Peking University People's Hospital, Beijing, China. guangzhi@public.bta.net.cn
authors.forename: G-Z
authors.initials: GZ
authors.lastname: Liu
authors.forename: A C
authors.initials: AC
authors.lastname: Gomes
authors.forename: P
authors.initials: P
authors.lastname: Putheti
authors.forename: V
authors.initials: V
authors.lastname: Karrenbauer
authors.forename: K
authors.initials: K
authors.lastname: Kostulas
authors.forename: R
authors.initials: R
authors.lastname: Press
authors.forename: J
authors.initials: J
authors.lastname: Hillert
authors.forename: P
authors.initials: P
authors.lastname: Hjelmström
authors.forename: X-G
authors.initials: XG
authors.lastname: Gao
mesh_terms: D053330:4-1BB Ligand; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism* / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008024:Ligands; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis / Q000097:blood; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology; D012333:RNA, Messenger / Q000096:biosynthesis; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism* / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology; D012995:Solubility; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9; D048069:Tumor Necrosis Factors / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics / Q000502:physiology
chemical_list: D053330:4-1BB Ligand; D015703:Antigens, CD; D008024:Ligands; D018950:Lipopolysaccharide Receptors; D012333:RNA, Messenger; D017475:Receptors, Nerve Growth Factor; D018124:Receptors, Tumor Necrosis Factor; C505714:TNFRSF9 protein, human; C505974:TNFSF9 protein, human; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9; D048069:Tumor Necrosis Factors