title: Antibody molecules discriminate between crystalline facets of a gallium arsenide semiconductor.
abstract: Seamless integration of biomolecules with manmade materials will most likely rely on molecular recognition and specific binding. In the following we show that combinatorial antibody libraries, based on the vast repertoire of the human immune system, can be harnessed to generate such binders. As a demonstration, we isolate antibody fragments that discriminate and bind selectively GaAs (111A) facets as opposed to GaAs (100). The isolated antibodies are utilized for exclusive localization of a fluorescent dye on (111A) surfaces in a structure comprising a mixture of (100) and (111A) surfaces. The potential importance of structure rigidity to facet recognition is suggested vis-a-vis published experiments with short and longer peptides.
authors.affiliation: Department of Biology, and The Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Arbel
authors.initials: A
authors.lastname: Artzy Schnirman
authors.forename: Efrat
authors.initials: E
authors.lastname: Zahavi
authors.forename: Hadas
authors.initials: H
authors.lastname: Yeger
authors.forename: Ronit
authors.initials: R
authors.lastname: Rosenfeld
authors.forename: Itai
authors.initials: I
authors.lastname: Benhar
authors.forename: Yoram
authors.initials: Y
authors.lastname: Reiter
authors.forename: Uri
authors.initials: U
authors.lastname: Sivan
mesh_terms: D000906:Antibodies / Q000737:chemistry*; D001152:Arsenicals / Q000737:chemistry*; D001665:Binding Sites; D032701:Biomimetics / Q000379:methods*; D003461:Crystallography / Q000379:methods*; D005708:Gallium / Q000737:chemistry*; D008422:Materials Testing / Q000379:methods; D015336:Molecular Probe Techniques; D011485:Protein Binding; D012666:Semiconductors; D013499:Surface Properties
chemical_list: D000906:Antibodies; D001152:Arsenicals; C043055:gallium arsenide; D005708:Gallium