Effects of thiazolidinediones on stroke recovery: a case-matched controlled study.
OBJECTIVE
Anti-inflammatory therapy decreases infarct size and enhances stroke recovery. Thiazolidinedione peroxisome proliferator-activated receptor (PPAR)gamma agonists have potent anti-inflammatory and insulin-sensitizing anti-diabetic actions.


METHODS
Thirty stroke patients with type 2 diabetes admitted for acute inpatient stroke rehabilitation receiving pioglitazone or rosiglitazone were matched for age, sex, initial FIM(TM) score and interval post-stroke with 30 stroke patients with type 2 diabetes not receiving thiazolidinediones. Relevant outcome variables were compared for both groups.


RESULTS
The thiazolidinedione treated group showed significantly greater mean improvement in FIM(TM) score compared to control group (25.6 +/- 10.2 SD vs. 19.8 +/- 10.5, respectively, P = 0.015). There was no significant difference in length of rehabilitation hospital stay (24.2 +/- 7.6 vs. 25.1 +/- 7.4 days, P = 0.657) or final discharge destination (home/institution, 19/11 versus 17/13, P = 0.792).


CONCLUSIONS
Use of thiazolidinediones was associated with enhanced functional recovery in stroke patients with type 2 diabetes.
Lee
Jongmin
J
Department of Rehabilitation Medicine, and Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, University Hospital, Konkuk University, Seoul, South Korea.
Reding
Michael
M
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003071:Cognition; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007902:Length of Stay; D008297:Male; D000077205:Pioglitazone; D012189:Retrospective Studies; D000077154:Rosiglitazone; D020521:Stroke / Q000150:complications / Q000188:drug therapy*; D000071939:Stroke Rehabilitation; D045162:Thiazolidinediones / Q000627:therapeutic use*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D000077205:Pioglitazone