title: Invasive Enterobacter sakazakii disease in infants.
abstract: Enterobacter sakazakii kills 40%-80% of infected infants and has been associated with powdered formula. We analyzed 46 cases of invasive infant E. sakazakii infection to define risk factors and guide prevention and treatment. Twelve infants had bacteremia, 33 had meningitis, and 1 had a urinary tract infection. Compared with infants with isolated bacteremia, infants with meningitis had greater birthweight (2,454 g vs. 850 g, p = 0.002) and gestational age (37 weeks vs. 27.8 weeks, p = 0.02), and infection developed at a younger age (6 days vs. 35 days, p<0.001). Among meningitis patients, 11 (33%) had seizures, 7 (21%) had brain abscess, and 14 (42%) died. Twenty-four (92%) of 26 infants with feeding patterns specified were fed powdered formula. Formula samples associated with 15 (68%) of 22 cases yielded E. sakazakii; in 13 cases, clinical and formula strains were indistinguishable. Further clarification of clinical risk factors and improved powdered formula safety is needed.
authors.affiliation: Foodborne and Diarrheal Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. abowen@cdc.gov
authors.forename: Anna B
authors.initials: AB
authors.lastname: Bowen
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Braden
mesh_terms: D044083:Cronobacter sakazakii; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D005516:Food Microbiology; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D008297:Male; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D012307:Risk Factors