title: Evaluation of intrauterine antibiotic treatment of clinical metritis and retained fetal membranes in dairy cows.
abstract: Retained fetal membranes (RFM) and clinical metritis (CM) are frequently diagnosed disease conditions in dairy cows and considered of major economic impact due to negative effect on reproduction and milk production. The objective of this study was to evaluate the efficacy of i.u. tetracycline for the treatment of RFM and CM in dairy cows. Affected cows were randomly assigned to two groups; treatment group animals received i.u. 5g chlortetracycline twice weekly for 2 wks, and no treatment group. A total of 1416 cows and 804 heifers in 5 herds calved during the study period. CM was diagnosed in 18.6% (inter farm range; 15.2-23.5%) and 30% (19.4-42.3%) of cows and heifers, respectively. RFM was diagnosed in 13.1% (9.4-18.1%) and 9.2% (3.6-13.8%) of cows and heifers, respectively. Conception rates after first insemination were 38.3%, 42.5% and 18% in normal, treated and non-treated CM cows, respectively. Numbers of days open were 140.5, 136.2 and 165.5 in normal, treated and non-treated CM cows, respectively. Based on 305-d corrected milk yield, cows and heifers affected by RFM and CM produced 300-500kg less milk compared with their normal herd mates. Cows treated for CM produced 654kg more milk per 305-d corrected lactation compared to non-treated control cows. Treatment of RFM had no effect on reproductive performance or milk production. In conclusion, i.u. chlortetracycline treatment was proven to prevent the detrimental effect of CM on reproductive performance in heifers and cows and on milk production in cows only.
authors.affiliation: The Koret School of Veterinary Medicine, Faculty of Agriculture, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel.
authors.forename: Tamir
authors.initials: T
authors.lastname: Goshen
authors.forename: Nahum Y
authors.initials: NY
authors.lastname: Shpigel
mesh_terms: D000367:Age Factors; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002751:Chlortetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004716:Endometritis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007774:Lactation / Q000187:drug effects / Q000502:physiology; D010298:Parity; D018457:Placenta, Retained / Q000188:drug therapy / Q000662:veterinary*; D049590:Postpartum Period; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002751:Chlortetracycline