title: In vitro antifungal susceptibility of clinical isolates of Candida spp. obtained from patients with different predisposing factors to candidosis.
abstract: The increase in the number of infections caused by Candida species and the consequent use of antifungal agents favours an increase of resistant isolates. The aim of this study was to evaluate the antifungal susceptibility of Candida spp. isolates from patients with different systemic predisposing factors to candidosis. Seventy-nine Candida spp. isolates were assayed for in vitro susceptibility to amphotericin B, fluconazole, 5-flucytosine and itraconazole using the technique proposed by the Clinical and Laboratory Standards Institute (CLSI). Four C. albicans, one C. guilliermondii, four C. parapsilosis and two C. tropicalis isolates were resistant to amphotericin B. Only two isolate was resistant to itraconazole. All the isolates tested were susceptible to fluconazole and flucytosine. It could be concluded that the most efficient drugs against the Candida isolates studied were fluconazole and flucytosine and that all of the antifungal agents used in this study were effective against the Candida spp. isolates tested.
authors.affiliation: Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil. Av. Antonio Carlos, 6627, 31270-901, Belo Horizonte, MG, Brazil.
authors.forename: Patrícia M
authors.initials: PM
authors.lastname: Pinto
authors.forename: Rita de Cássia Botelho
authors.initials: Rde C
authors.lastname: Weikert-Oliveira
authors.forename: Juliana Pereira
authors.initials: JP
authors.lastname: Lyon
authors.forename: Verônica F
authors.initials: VF
authors.lastname: Cury
authors.forename: Rodrigo R
authors.initials: RR
authors.lastname: Arantes
authors.forename: Cristiane Y
authors.initials: CY
authors.lastname: Koga-Ito
authors.forename: Maria A
authors.initials: MA
authors.lastname: Resende
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D004198:Disease Susceptibility; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents