Mice naturally resistant to Yersinia pestis Delta pgm strains commonly used in pathogenicity studies.
We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Deltapgm strains of Yersinia pestis; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.
Congleton
Yasemin H K
YH
Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536-0298, USA.
Wulff
Christine R
CR
Kerschen
Edward J
EJ
Straley
Susan C
SC
D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D010930:Plague / Q000235:genetics / Q000276:immunology* / Q000382:microbiology* / Q000401:mortality; D015010:Yersinia pestis / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity