title: Posaconazole for treatment of refractory invasive fungal disease.
abstract: Invasive fungal infections are usually associated with immunocompromised states About 40-60% of these patients are refractory to standard antifungal therapy We describe the effect of posaconazole in the treatment of a 12 years-old girl with uncontrolled diabetes mellitus with life-threatening cerebral mucor mycosis and a 4 year old girl boy with chronic granulomatous disease presenting with invasive Aspergillus nidulans infection.
authors.affiliation: University Childrens Hospital, Munich, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Notheis
authors.forename: L
authors.initials: L
authors.lastname: Tarani
authors.forename: F
authors.initials: F
authors.lastname: Costantino
authors.forename: A
authors.initials: A
authors.lastname: Jansson
authors.forename: J
authors.initials: J
authors.lastname: Rosenecker
authors.forename: D
authors.initials: D
authors.lastname: Friederici
authors.forename: B H
authors.initials: BH
authors.lastname: Belohradsky
authors.forename: D
authors.initials: D
authors.lastname: Reinhardt
authors.forename: R
authors.initials: R
authors.lastname: Seger
authors.forename: D V
authors.initials: DV
authors.lastname: Schweinitz
authors.forename: Uwe
authors.initials: U
authors.lastname: Wintergerst
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001233:Aspergillus nidulans / Q000187:drug effects / Q000302:isolation & purification; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D025141:Drug Resistance, Fungal; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D009091:Mucormycosis / Q000188:drug therapy* / Q000382:microbiology; D012233:Rhizopus / Q000187:drug effects / Q000302:isolation & purification; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole