title: Quantitative analysis of chondroitin sulfate in tear fluids following laser in situ keratomileusis.
abstract: OBJECTIVE
  To report chondroitin sulfate (CS) concentrations in tear fluid following laser in situ keratomileusis (LASIK).
  
  
  METHODS
  Fourteen eyes that underwent LASIK were enrolled. We measured the CS isomers chondroitin 4 sulfate and chondroitin 6 sulfate using an enzyme-linked immunosorbent assay preoperatively and postoperatively on days 1 and 4, week 1, and 1 and 3 months.
  
  
  RESULTS
  The chondroitin 4 sulfate concentration remained unchanged from preoperative values. The chondroitin 6 sulfate concentration increased temporarily 1 day postoperatively and gradually decreased thereafter.
  
  
  CONCLUSIONS
  CS in tear fluids participates in wound healing after LASIK. Clarifying its role in tear fluids will contribute to improved LASIK outcomes.
authors.affiliation: Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Nishio
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Arai
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000601:surgery; D002809:Chondroitin Sulfates / Q000378:metabolism*; D003315:Cornea / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008297:Male; D009216:Myopia / Q000601:surgery; D013666:Tears / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
chemical_list: D002809:Chondroitin Sulfates