Dosimetry in Peptide radionuclide receptor therapy: a review.
The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.
Cremonesi
Marta
M
Division of Medical Physics, European Institute of Oncology, Milan, Italy.
Ferrari
Mahila
M
Bodei
Lisa
L
Tosi
Giampiero
G
Paganelli
Giovanni
G
D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D010455:Peptides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011868:Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D018000:Receptors, Peptide / Q000378:metabolism
D010455:Peptides; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D018000:Receptors, Peptide