Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers.
New carbon-11 and fluorine-18 labeled stilbene derivatives, cis-3,5-dimethoxy-4'-[11C]methoxystilbene (4'-[11C]8a), cis-3,4',5-trimethoxy-3'-[11C]methoxystilbene (3'-[11C]8b), trans-3,5-dimethoxy-4'-[11C]methoxystilbene (4'-[11C]10a), trans-3,4',5-trimethoxy-3'-[11C]methoxystilbene (3'-[11C]10b), cis-3,5-dimethoxy-4'-[18F]fluorostilbene (4'-[18F]12a), and trans-3,5-dimethoxy-4'-[18F]fluorostilbene (4'-[18F]13a), were designed and synthesized as potential PET probes for aryl hydrocarbon receptor (AhR) in cancers.
Gao
Mingzhang
M
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Wang
Min
M
Miller
Kathy D
KD
Sledge
George W
GW
Hutchins
Gary D
GD
Zheng
Qi-Huang
QH
D000818:Animals; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D008956:Models, Chemical; D009369:Neoplasms / Q000175:diagnosis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D051381:Rats; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*; D013237:Stereoisomerism; D013267:Stilbenes / Q000138:chemical synthesis*; D014055:Tomography, Emission-Computed / Q000379:methods
D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D018336:Receptors, Aryl Hydrocarbon; D013267:Stilbenes