title: Salivary fluoride from fluoride dentifrices or rinses after use of a calcium pre-rinse or calcium dentifrice.
abstract: The low concentration of available calcium (Ca) in oral fluids limits the formation of Ca-mediated fluoride deposits that maintain oral fluoride (F) after a topical F treatment. The purpose of this study was to examine if a high concentration of Ca would increase salivary F when used before a F rinse or dentifrice. We found that a Ca pre-rinse (150 mmol/l Ca lactate) or Ca dentifrice (0.084 g Ca glycerolphosphate per gram dentifrice) used immediately before a 60 s 228-ppm F rinse (12 mmol/l NaF) produced a 4.6x or 3.6x increase (p < 0.05) respectively in the 1 h salivary F concentrations over the F rinse alone. Reducing the post-Ca F rinse to 10 s still produced a significant 2.2x increase in salivary F compared to the 60 s F rinse alone. Used with a conventional 1,100 ppm F (i.e. 1,100 microg F per gram) NaF dentifrice (Crest), the above Ca pre-rinse increased 1 h salivary F levels by 2.3x over the F dentifrice alone. However, a F rinse given before a Ca rinse produced no increase in 1 h salivary F concentrations. Although the persistence of these increases requires further study, these results suggest that a moderately high concentration of Ca given shortly before a F rinse or F dentifrice may increase the cariostatic effect of the F product.
authors.affiliation: American Dental Association Foundation, Paffenbarger Research Center, Gaithersburg, MD 20899-8546, USA. jvogel@nist.gov
authors.forename: G L
authors.initials: GL
authors.lastname: Vogel
authors.forename: D
authors.initials: D
authors.lastname: Shim
authors.forename: G E
authors.initials: GE
authors.lastname: Schumacher
authors.forename: C M
authors.initials: CM
authors.lastname: Carey
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
authors.forename: S
authors.initials: S
authors.lastname: Takagi
mesh_terms: D001682:Biological Availability; D002118:Calcium / Q000494:pharmacology*; D017610:Calcium Compounds; D002124:Calcium Fluoride / Q000493:pharmacokinetics*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D003802:Dentifrices / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005459:Fluorides / Q000032:analysis*; D005994:Glycerophosphates; D006801:Humans; D007773:Lactates; D008297:Male; D009067:Mouthwashes / Q000494:pharmacology; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012969:Sodium Fluoride / Q000627:therapeutic use*
chemical_list: D017610:Calcium Compounds; D002327:Cariostatic Agents; D003802:Dentifrices; D005994:Glycerophosphates; D007773:Lactates; D009067:Mouthwashes; C110051:calcium lactate; D012969:Sodium Fluoride; D002124:Calcium Fluoride; D005459:Fluorides; D002118:Calcium