title: A clonal translocation (7;8)(p13;q11.2) in a leiomyoma of the vulva.
abstract: We present the first case of a vulvar leiomyoma studied by cytogenetics. The tumor formed a 3.0-cm periurethral nodule in a middle-aged woman and was positive for the muscle markers desmin and caldesmon, and for estrogen and progesterone receptors. Its karyotype was 46,XX,t(7;8)(p13;q11.2). This translocation has not been described in previously reported leiomyomas, regardless of their site of origin. The transcription factor PLAG1 gene at 8q12 was not altered by the translocation.
authors.affiliation: Department of Pathology, Scott and White Memorial Hospital and Clinic, Scott, Sherwood and Brindley Foundation, 2401 South 31st Street, Temple, TX, USA.
authors.forename: Elaine
authors.initials: E
authors.lastname: Horton
authors.forename: Sheila M
authors.initials: SM
authors.lastname: Dobin
authors.forename: Maria
authors.initials: M
authors.lastname: Debiec-Rychter
authors.forename: Ludvik R
authors.initials: LR
authors.lastname: Donner
mesh_terms: D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic; D014846:Vulvar Neoplasms / Q000235:genetics*