title: Characterisation of Neisseria meningitidis C:2b:P1.2,5 isolates in Poland.
abstract: This study aimed to characterise Neisseria meningitidis C:2b:P1.2,5 isolates from Poland, which have now become predominant among serogroup C isolates in this country. Overall, 44 isolates (25 invasive and 19 from contact carriers) were typed by whole-cell ELISA and pulsed-field gel electrophoresis. Additionally, the invasive isolates were analysed by multilocus sequence typing, which revealed that they all belonged to the ST-8 complex/cluster A4. The emergence of this clone in other countries has resulted in mass immunisation campaigns and has been associated with a higher level of decreased susceptibility to penicillin; however the present study detected only one isolate that was penicillin-non-susceptible.
authors.affiliation: Department of Epidemiology and Clinical Microbiology, National Reference Centre for Bacterial Meningitis, National Institute of Public Health, Warsaw, Poland. skoczek@cls.edu.pl
authors.forename: A
authors.initials: A
authors.lastname: Skoczyńska
authors.forename: M
authors.initials: M
authors.lastname: Kadłubowski
authors.forename: I
authors.initials: I
authors.lastname: Waśko
authors.forename: W
authors.initials: W
authors.lastname: Hryniewicz
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000235:genetics* / Q000302:isolation & purification* / Q000378:metabolism; D011044:Poland / Q000453:epidemiology