title: Association of a functional polymorphism in the serotonin transporter gene with personality traits in females in a Polish population.
abstract: The aim of our study was to determine whether the 5-HTTLPR polymorphism is related to temperamental traits measured using the Formal Characteristics of Behavior - Temperament Inventory (FCB-TI) and personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI) questionnaire. The sample comprised 200 unrelated females, aged 18-29 years. DNA of the subjects was isolated from buccal epithelial cells, and 5-HTTLPR polymorphism was genotyped using PCR. The subjects were divided into SS, SL and LL groups according to their genotype. The differences in results on the endurance scale (F = 11.29, p = 0.001), measured using FCB-TI and neuroticism measured using NEO-FFI (F = 15.32, p = 0.000) between the S group (short-form allele; genotypes SS and SL) and the L group (long-form allele; genotype LL) were statistically significant. Additionally, statistically significant differences between the LL and SS groups, and between the SL and SS groups with respect to 'activity' (FCB-TI) were found (F = 4.5, p = 0.012). These findings support a role of the 5-HTTLPR polymorphism in the modulation of personality and temperamental traits.
authors.affiliation: The Interdisciplinary Center for Behavior Genetic Research, University of Warsaw, Warsaw, Poland. wdragan@psych.uw.edu.pl
authors.forename: Wojciech Ł
authors.initials: WŁ
authors.lastname: Dragan
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Oniszczenko
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D005838:Genotype; D006801:Humans; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory / Q000706:statistics & numerical data; D011044:Poland / Q000208:ethnology; D011110:Polymorphism, Genetic; D011594:Psychometrics / Q000379:methods; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013694:Temperament / Q000502:physiology
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins