Migration abnormality in the left cingulate gyrus presenting with autistic disorder.
Autism, characterized by an impairment in communication, including language, narrowly focused interests, and poor sociability, is a neurodevelopmental disorder of still largely unknown pathogenesis. In children with autistic symptomatology, the most consistent functional or anatomic abnormalities are found in the cingulate gyrus, particularly in the anterior regions. Neuronal migration malformations caused by incomplete neuronal migration and characterized by loss of the normal gyral patterns in the cerebral hemispheres and prominent disorganization of the cerebral cortical cytoarchitecture are generally associated with profound neurologic deficits, epilepsy, and autism. In this report, we present a case with an isolated migration abnormality located in the anterior part of the left cingulate gyrus who was admitted with the complaints of epileptic seizures and autism. In addition, the role of the localization of the migration abnormality in the appearance of autistic symptomatology is discussed.
Korkmaz
Bariş
B
Division of Child Neurology, Neurology Department, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey. bkorkmaz@istanbul.edu.tr
Benbir
Gülçin
G
Demirbilek
Veysi
V
D001321:Autistic Disorder / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D002465:Cell Movement / Q000502:physiology*; D002675:Child, Preschool; D004827:Epilepsy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009474:Neurons / Q000502:physiology*