title: Effects of epidural administration of morphine and buprenorphine on the minimum alveolar concentration of isoflurane in cats.
abstract: OBJECTIVE
  To determine effects of epidural administration of morphine and buprenorphine on the minimum alveolar concentration of isoflurane in cats. Animals-6 healthy adult domestic shorthair cats.
  
  
  METHODS
  Cats were anesthetized with isoflurane in oxygen. Morphine (100 microg/kg diluted with saline [0.9% NaCl] solution to a volume of 0.3 mL/kg), buprenorphine (12.5 microg/kg diluted with saline solution to a volume of 0.3 mL/kg), or saline solution (0.3 mL/kg) was administered into the epidural space according to a Latin square design. The minimum alveolar concentration (MAC) of isoflurane was measured in triplicate by use of the tail clamp technique. At least 1 week was allowed between successive experiments.
  
  
  RESULTS
  The MAC of isoflurane was 2.00 +/- 0.18%, 2.13 +/- 0.11%, and 2.03 +/- 0.09% in the morphine, buprenorphine, and saline solution groups, respectively. No significant difference in MAC was detected among treatment groups.
  
  
  CONCLUSIONS
  A significant effect of epidural administration of morphine or buprenorphine on the MAC of isoflurane in cats could not be detected. Further studies are needed to establish whether epidural opioid administration has other benefits when administered as a component of general anesthesia in cats.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: Bruno H
authors.initials: BH
authors.lastname: Pypendop
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Pascoe
authors.forename: Jan E
authors.initials: JE
authors.lastname: Ilkiw
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D000767:Anesthesia, Epidural / Q000379:methods / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002047:Buprenorphine / Q000494:pharmacology*; D002415:Cats / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000493:pharmacokinetics* / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000701:Analgesics, Opioid; D018685:Anesthetics, Inhalation; D002047:Buprenorphine; D009020:Morphine; D007530:Isoflurane