Breast cancer in African-American women: differences in tumor biology from European-American women.
Disparities exist between African-American and European-American women in the incidence and nature of breast cancer. African-American women are more often diagnosed with breast cancer at an earlier age and with more aggressive disease, characterized by higher grade and negative estrogen and progesterone receptor status. Recent findings reveal specific gene expression patterns associated with the more aggressive breast cancers observed in African-American women. An overview of the current literature about racial differences in breast cancer prompts questions for future research to elucidate causes for the apparent disparities in tumor biology.
Amend
Kandace
K
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA.
Hicks
David
D
Ambrosone
Christine B
CB
D044383:Black People; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015994:Incidence; D010641:Phenotype; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D018570:Risk Assessment; D014481:United States / Q000453:epidemiology; D044465:White People; D001741:Black or African American
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone