title: Chronic development of ischaemic mitral regurgitation during post-infarction remodelling.
abstract: OBJECTIVE
  Mitral regurgitation (MR) following myocardial infarction (MI) may be a (sub)acute complication which independently predicts reduced survival. We sought to evaluate the chronic development of MR as potential consequence of left-ventricular (LV) remodelling, the latter being a long-term process.
  
  
  RESULTS
  Retrospectively, 103 post-MI patients were included according to a standardised Doppler echocardiogram <3 months following MI (20 +/- 25 days post-MI) and a follow-up examination >6 months after the first examination (5.1 +/- 3.1 years post-MI). Patients were clinically followed up for 7.6 +/- 2.7 years. Group I patients were defined as those showing new development or deterioration in one of three grades of MR, and group II those without this criterion (MR grade acute 0.17 vs. 0.27, p = 0.7, and chronic 1.53 vs. 0.19, p < 0.0001). Patient characteristics were similar in respect of age, gender, size and location of infarction. However, group I patients had coronary artery disease with more vessels involved. With regard to echocardiographic parameters of significantly enlarged LV chamber size in group I vs. group II, the significant decrease in LV performance was more pronounced and occurred concomitant with a higher degree of symptomatic congestive heart failure and greater need for heart failure medications in group I. Mortality in group I patients was 39 versus 9% in group II patients (p = 0.0002), approximating an odds ratio of 6.4697 (95% confidence interval: 2.211-18.931).
  
  
  CONCLUSIONS
  First of all, this retrospective study indicates that MR may be detected in patients after MI during a long-term follow-up most probably due to geometric distortions of LV remodelling resulting in a significantly higher mortality. Since this process is known to become irreversible at a certain point, serial echocardiography may help to detect MR in post-MI patients and thus pave the way for appropriate treatment.
authors.affiliation: Second Medical Clinic, Friedrich Alexander University, Erlangen-Nuremberg, Germany. uwe.nixdorff@t-online.de
authors.forename: Uwe
authors.initials: U
authors.lastname: Nixdorff
authors.forename: Lutz
authors.initials: L
authors.lastname: Klinghammer
authors.forename: Gertrud
authors.initials: G
authors.lastname: Wüstefeld
authors.forename: Susanne
authors.initials: S
authors.lastname: Mohr-Kahaly
authors.forename: Ralph Stephan
authors.initials: RS
authors.lastname: von Bardeleben
mesh_terms: D000368:Aged; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000503:physiopathology*; D009203:Myocardial Infarction / Q000150:complications*; D017202:Myocardial Ischemia / Q000150:complications*; D012189:Retrospective Studies; D020257:Ventricular Remodeling / Q000502:physiology*