title: Association of excess weight and degree of airway responsiveness in asthmatics and non-asthmatics.
abstract: It is unclear whether obesity is associated with increasing degree of airway responsiveness in asthmatics. In this study, methacholine challenge test results of 1,725 subjects with respiratory symptoms were reviewed. Obesity was associated with asthma with an odds ratio of 1.72 (95% C.I. 1.36, 2.17). Although there was a significant difference in the degree of airway responsiveness between various body mass index categories of non-asthmatics (p = 0.01), no significant difference was noted among asthmatics (p = 0.93). A weakly significant interaction between asthma status and body mass index on the degree of airway responsiveness was noted (p = 0.08).
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of New Mexico Health Sciences Center School of Medicine, Albuquerque, 87131, USA. asood@salud.unm.edu
authors.forename: Akshay
authors.initials: A
authors.lastname: Sood
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Verhulst
authors.forename: Adarsh
authors.initials: A
authors.lastname: Varma
authors.forename: Lanie E
authors.initials: LE
authors.lastname: Eagleton
authors.forename: Joseph Q
authors.initials: JQ
authors.lastname: Henkle
authors.forename: Patricia
authors.initials: P
authors.lastname: Hopkins-Price
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000503:physiopathology*; D015992:Body Mass Index; D016535:Bronchial Hyperreactivity / Q000209:etiology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012189:Retrospective Studies
chemical_list: D016210:Methacholine Chloride