title: Behavioral interference and C/EBPbeta expression in the insular-cortex reveal a prolonged time period for taste memory consolidation.
abstract: Memory consolidation is defined as the time window during which the memory trace is susceptible to behavioral, electrical, or pharmacological interventions. Here, we presented rats with two novel tastes at consecutive time intervals. Clear interference was evident when a novel taste formed the second taste input whereby, surprisingly, the time window for interference was found to last more than 10 h. In addition, we detected an increase of C/EBPbeta protein expression in the gustatory cortex 18 h after novel taste learning. This modulation was attenuated by a subsequent novel taste. Our findings reveal temporal constraints and a lingering nature of taste memory consolidation.
authors.affiliation: Department for Neurobiology and Ethology, Center for Brain and Behavior, University of Haifa, Haifa 31905, Israel.
authors.forename: Maayan
authors.initials: M
authors.lastname: Merhav
authors.forename: Shelly
authors.initials: S
authors.lastname: Kuulmann-Vander
authors.forename: Alina
authors.initials: A
authors.lastname: Elkobi
authors.forename: Shlomit
authors.initials: S
authors.lastname: Jacobson-Pick
authors.forename: Avi
authors.initials: A
authors.lastname: Karni
authors.forename: Kobi
authors.initials: K
authors.lastname: Rosenblum
mesh_terms: D000818:Animals; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004193:Discrimination Learning / Q000502:physiology*; D008297:Male; D010470:Perceptual Masking / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000502:physiology*; D013997:Time Factors
chemical_list: D022782:CCAAT-Enhancer-Binding Protein-beta