title: Rhinocerebral zygomycosis in a young girl undergoing allogeneic stem cell transplantation for severe aplastic anaemia.
abstract: We report on a 10-year-old girl with severe aplastic anaemia who developed rhinocerebral infection caused by Absidia corymbifera and a possible co-infection caused by Alternaria alternata. Despite prolonged neutropenia, therapy with liposomal amphotericin B and posaconazole improved the clinical condition. Subsequently, the girl underwent allogeneic haematopoietic stem cell transplantation (HSCT) for the underlying disease, but the fungal infection remained under control with the antifungal treatment. No severe side effect of the antifungal drugs was noted. Unfortunately, the girl died 5 months after HSCT due to disseminated adenovirus infection.
authors.affiliation: Department of Pediatric Hematology and Oncology, University of Frankfurt, Frankfurt, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Sörensen
authors.forename: Martina
authors.initials: M
authors.lastname: Becker
authors.forename: Luciana
authors.initials: L
authors.lastname: Porto
authors.forename: Evelyn
authors.initials: E
authors.lastname: Lambrecht
authors.forename: Tobias
authors.initials: T
authors.lastname: Schuster
authors.forename: Florian
authors.initials: F
authors.lastname: Beske
authors.forename: Volker
authors.initials: V
authors.lastname: Rickerts
authors.forename: Thomas
authors.initials: T
authors.lastname: Klingebiel
authors.forename: Thomas
authors.initials: T
authors.lastname: Lehrnbecher
mesh_terms: D020095:Absidia / Q000302:isolation & purification; D000528:Alternaria / Q000302:isolation & purification; D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications* / Q000628:therapy; D000935:Antifungal Agents / Q000627:therapeutic use; D020314:Central Nervous System Fungal Infections / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D005260:Female; D006801:Humans; D011859:Radiography; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D013687:Telencephalon / Q000000981:diagnostic imaging / Q000382:microbiology; D014184:Transplantation, Homologous / Q000009:adverse effects*; D014230:Triazoles / Q000627:therapeutic use; D020096:Zygomycosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B