title: [Effect of resveratrol on the cognitive ability of Alzheimeros mice].
abstract: OBJECTIVE
  To explore the effect of resveratrol on the cognition of Alzheimer's mice (AD) and its mechanism, and to assess its action on the reproduction system.
  
  
  METHODS
  According to the results of step-down test, 84 Kunming female mice were randomly divided into 6 groups: Group A [sham operated+1% CMC-Na (0.01 mL/g)], Group B [ovariectomy+D-galactose+1% CMC-Na (0.01 mL/g)], Group C [ovariectomy+D-galactose+0.05 mg/(kg.d) Diethylstilbestrol], Group D [ovariectomy+D-galactose+15 mg/(kg.d) Res], and Group E [ovariectomy+D-galactose injected+45 mg/(kg.d) Res], and Group F [ovariectomy+D-galactose +135 mg/(kg.d) Res]. Experimental cycle was 60 days.
  
  
  RESULTS
  Resveratrol of every dosage could improve the performance records of behavior tests in AD mice,could inhibit the SOD vitality and the MDA level both in the serum and in the brain, and could suppress the acetylcholinesterase vitality and the bax expression. Resveratrol has no endometrial hyperplasia effect.
  
  
  CONCLUSIONS
  Resveratrol can improve the cognitive ability of AD mice, which may contribute to the resveratrol's antioxidation and antiapoptosis, and can modulate acetylcholinesterase. Resveratrol has no side-effect of endometrial hyperplasia on AD mice.
authors.affiliation: Deparment of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078, China.
authors.forename: Li
authors.initials: L
authors.lastname: Luo
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Huang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D005260:Female; D005690:Galactose; D051379:Mice; D010052:Ovariectomy; D011897:Random Allocation; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol; D005690:Galactose