Gene therapy for pulmonary diseases.
Gene therapy has not yet met the high expectations of "the early days." However, it is a promising new treatment for lung diseases. Not only single gene disorders such as CF are potential candidates for gene therapy, but also cancer and chronic lung diseases characterized by an imbalance of damaging and protective mechanisms. This review summarizes the recent advances in the development of more efficient gene transfer systems and highlights areas of clinical application of gene therapy.
Kolb
Martin
M
Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5.
Martin
Gail
G
Medina
Maria
M
Ask
Kjetil
K
Gauldie
Jack
J
D000818:Animals; D001249:Asthma / Q000235:genetics / Q000628:therapy; D003550:Cystic Fibrosis / Q000235:genetics / Q000628:therapy; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy; D008171:Lung Diseases / Q000235:genetics* / Q000628:therapy*; D008175:Lung Neoplasms / Q000235:genetics / Q000628:therapy; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics / Q000628:therapy; D000515:alpha 1-Antitrypsin / Q000235:genetics
C505032:CFTR protein, human; D000515:alpha 1-Antitrypsin; D019005:Cystic Fibrosis Transmembrane Conductance Regulator