title: Intermediary metabolism in sea urchin: the first inferences from the genome sequence.
abstract: The genome sequence of the purple sea urchin Strongylocentrotus purpuratus recently became available. We report the results of functional annotation and initial analysis of more than 2300 proteins predicted to be involved in metabolite transport and enzymatic conversion in sea urchin. The comparison of various reconstructed biosynthetic and catabolic pathways in sea urchin to those known in other genomes suggests the overall similarity of the sea urchin metabolism to that of the vertebrates, with relatively small but non-trivial differences from both vertebrates and protostomes. There are several examples of two parallel, non-orthologous solutions for the same molecular function in sea urchin, in contrast with the other completely sequenced metazoans that tend to contain just one version of the same function. There are also genes that appear to be close phylogenetic neighbors of plant or bacterial homologs, as opposed to homologs in other Metazoa. The evolutionary and functional significance of these variations is discussed.
authors.affiliation: Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA.
authors.forename: Manisha
authors.initials: M
authors.lastname: Goel
authors.forename: Arcady
authors.initials: A
authors.lastname: Mushegian
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D016678:Genome; D009711:Nucleotides / Q000378:metabolism; D010802:Phylogeny; D012617:Sea Urchins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D014508:Urea / Q000378:metabolism
chemical_list: D000596:Amino Acids; D009711:Nucleotides; D014508:Urea