title: Control of Caenorhabditis elegans life history by nuclear receptor signal transduction.
abstract: Caenorhabditis elegans diapause, reproductive development, and life span are influenced by the DAF-12 nuclear hormone receptor signaling pathway. Here, we describe how this nuclear receptor integrates environmental and physiologic cues and regulates developmental age, reproduction and aging.
authors.affiliation: Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Veerle
authors.initials: V
authors.lastname: Rottiers
authors.forename: Adam
authors.initials: A
authors.lastname: Antebi
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D017238:Genes, Helminth / Q000235:genetics; D008018:Life Cycle Stages / Q000235:genetics / Q000502:physiology; D008136:Longevity / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013256:Steroids / Q000502:physiology
chemical_list: D029742:Caenorhabditis elegans Proteins; C410905:DAF-12 protein, C elegans; D018160:Receptors, Cytoplasmic and Nuclear; D013256:Steroids