title: [Diagnostic imaging of skeletal metastases].
abstract: Skeletal metastases are the most frequent in malignant bone tumor. Vast majority of skeletal metastases are encountered in middle-aged to elderly persons. Skeletal metastases should be included in differential diagnosis of bone lesion in elderly persons. In this mini-review, clinical features are mainly discussed and some recent advances are also described. They are 1) mechanisms of skeletal metastasis, 2) vicious cycle (what happens in the process of osseous metastasis progression), 3) frequency, site and number of skeletal metastases, 4) osseous response to metastatic tumor, 5) diagnostic imaging of skeletal metastasis, 6) bone metabolic markers in osseous metastasis, and 7) complications.
authors.affiliation: Department of Nuclear Medicine, Cancer Institute Hospital.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Koizumi
authors.forename: Masamichi
authors.initials: M
authors.lastname: Koyama
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D003952:Diagnostic Imaging; D006801:Humans; D008875:Middle Aged