title: Chronic active thrombotic microangiopathy in native and transplanted kidneys.
abstract: We report 2 complicated cases of thrombotic microangiopathy with chronic features and active components. The first case was a 36-yr-old woman with positive anti-DNA antibody and possible lupus cerebritis, who developed thrombotic microangiopathy secondary to a series of syndromes, including preeclampsia and anti-phospholipid antibody syndrome. Renal biopsy revealed no evidence of lupus nephritis and her renal function returned to normal 1 week after the biopsy. The second case was a 46-yr-old man who developed thrombotic microangiopathy of unknown etiology, which led to end-stage renal disease within 6 mo. The patient received a living related-donor transplant, but thrombotic microangiopathy recurred in the donor kidney only 40 days after the renal transplantation.
authors.affiliation: Laboratory Medicine, Geisinger Medical Center, 100 North Academy, Danville, PA 17822, USA. plzhang@geisinger.edu
authors.forename: Ping L
authors.initials: PL
authors.lastname: Zhang
authors.forename: Jeffery W
authors.initials: JW
authors.lastname: Prichard
authors.forename: Fan
authors.initials: F
authors.lastname: Lin
authors.forename: Michael F
authors.initials: MF
authors.lastname: Shultz
authors.forename: Sayeed K
authors.initials: SK
authors.lastname: Malek
authors.forename: John H
authors.initials: JH
authors.lastname: Shaw
authors.forename: James E
authors.initials: JE
authors.lastname: Hartle
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications; D002908:Chronic Disease; D005260:Female; D050533:Glomerular Basement Membrane / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology; D016030:Kidney Transplantation / Q000473:pathology; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D013921:Thrombocytopenia / Q000209:etiology; D013927:Thrombosis / Q000150:complications*