Hearing suppression induced by electrical stimulation of human auditory cortex.
In the course of performing electrical stimulation functional mapping (ESFM) in neurosurgery patients, we identified three subjects who experienced hearing suppression during stimulation of sites within the superior temporal gyrus (STG). One of these patients had long standing tinnitus that affected both ears. In all subjects, auditory event related potentials (ERPs) were recorded from chronically implanted intracranial electrodes and the results were used to localize auditory cortical fields within the STG. Hearing suppression sites were identified within anterior lateral Heschl's gyrus (HG) and posterior lateral STG, in what may be auditory belt and parabelt fields. Cortical stimulation suppressed hearing in both ears, which persisted beyond the period of electrical stimulation. Subjects experienced other stimulation-evoked perceptions at some of these same sites, including symptoms of vestibular activation and alteration of audio-visual speech processing. In contrast, stimulation of presumed core auditory cortex within posterior medial HG evoked sound perceptions, or in one case an increase in tinnitus intensity, that affected the contralateral ear and did not persist beyond the period of stimulation. The current results confirm a rarely reported experimental observation, and correlate the cortical sites associated with hearing suppression with physiologically identified auditory cortical fields.
Fenoy
Albert J
AJ
Department of Neurosurgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA. albert-fenoy@uiowa.edu
Severson
Meryl A
MA
Volkov
Igor O
IO
Brugge
John F
JF
Howard
Matthew A
MA
D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods; D004558:Electric Stimulation / Q000009:adverse effects / Q000379:methods; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery; D005071:Evoked Potentials / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006313:Hearing Loss, Central / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007088:Illusions / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D019635:Neurosurgical Procedures; D013067:Speech Perception / Q000502:physiology; D014012:Tinnitus / Q000209:etiology / Q000503:physiopathology