title: Role of hospital stay and antibiotic use on Pseudomonas aeruginosa gastrointestinal colonization in hospitalized patients.
abstract: The prospective cohort study presented here assessed the risk factors associated with Pseudomonas aeruginosa gastrointestinal colonization (PAGIC) in 933 patients hospitalized in five different wards in a French university hospital. A total of 195 patients were colonized. By logistic regression, hospitalization in an intensive care unit and length of hospital stay were independent risk factors. A significant association was observed between fluoroquinolone use and PAGIC caused by an ofloxacin-resistant strain (p < 0.0001), imipenem use and PAGIC caused by an imipenem-resistant strain (p < 0.0002) and ceftazidime use and PAGIC caused by a ceftazidime-resistant strain (p < 0.02). The ecological impact of antibiotic use is of great clinical relevance and clinicians should consider antimicrobial resistance in order to limit the development and dissemination of resistant microorganisms.
authors.affiliation: Laboratoire de Bactériologie-Virologie et d'Hygiène, Institut de Biologie, Hôtel-Dieu, Place A. Ricordeau, 44093 Nantes, France. didier.lepelletier@chu-nantes.fr
authors.forename: D
authors.initials: D
authors.lastname: Lepelletier
authors.forename: N
authors.initials: N
authors.lastname: Caroff
authors.forename: D
authors.initials: D
authors.lastname: Riochet
authors.forename: P
authors.initials: P
authors.lastname: Bizouarn
authors.forename: A
authors.initials: A
authors.lastname: Bourdeau
authors.forename: F
authors.initials: F
authors.lastname: Le Gallou
authors.forename: E
authors.initials: E
authors.lastname: Espaze
authors.forename: A
authors.initials: A
authors.lastname: Reynaud
authors.forename: H
authors.initials: H
authors.lastname: Richet
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003428:Cross Infection / Q000382:microbiology*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000302:isolation & purification*; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents