Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress.
This study was designed to determine the effect of diphenyl diselenide and ebselen, synthetic organoselenium compounds with antioxidant properties, in diabetic rats. Diabetes was induced by the administration of streptozotocin (STZ) (45mg/kg, intravenous). In experimental trials, diphenyl diselenide, but not ebselen, caused a significant reduction in blood glucose levels of STZ-treated rats. This effect of diphenyl diselenide was accompanied by a reduction in the levels of glycated proteins. Diphenyl diselenide ameliorate superoxide dismutase activity (liver and erythrocytes) and Vitamin C levels (liver, kidney and blood), which were decreased in STZ-treated rats. In normal rats, diphenyl diselenide caused per se an increase in hepatic, renal and blood GSH levels. Similarly, treatment with diphenyl diselenide restored hepatic and renal GSH levels in STZ-treated rats. TBARS and protein carbonyl levels were not modified by STZ and/or diphenyl diselenide and ebselen treatments. Our findings suggest that diphenyl diselenide can be considered an anti-diabetogenic agent by exhibiting anti-hyperglycemic and antioxidant properties.
Barbosa
N B V
NB
Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil.
Rocha
J B T
JB
Wondracek
D C
DC
Perottoni
J
J
Zeni
G
G
Nogueira
C W
CW
D000410:Alanine Transaminase / Q000097:blood; D000622:Aminolevulinic Acid / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001393:Azoles / Q000494:pharmacology; D001555:Benzene Derivatives / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D019270:Fructosamine / Q000097:blood; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D054833:Isoindoles; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D016566:Organoselenium Compounds / Q000494:pharmacology*; D018384:Oxidative Stress; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000410:Alanine Transaminase; D000622:Aminolevulinic Acid; D000975:Antioxidants; D001205:Ascorbic Acid; D001219:Aspartate Aminotransferases; D001393:Azoles; D001555:Benzene Derivatives; D001786:Blood Glucose; D019270:Fructosamine; D005978:Glutathione; D006442:Glycated Hemoglobin; D054833:Isoindoles; D007770:L-Lactate Dehydrogenase; D016566:Organoselenium Compounds; D000254:Sodium-Potassium-Exchanging ATPase; D013482:Superoxide Dismutase; C061132:diphenyldiselenide; C042986:ebselen