title: Use of the SCOT solution in kidney transplantation: preliminary report.
abstract: METHODS
  This article reports preliminary findings relating to the use of a new preservation solution, the Solution de Conservation des Organes et des Tissus (SCOT), in renal transplantation. This fourth-generation solution combines an extracellular-like composition with 20 kDa polyethylene-glycol, known for its cell-protection capacity and immunocamouflage properties.
  
  
  METHODS
  We have reported preliminary data obtained in 29 transplantations (25 cadaveric donors and 4 living related donors) between December 2004 and November 2005. The SCOT solution was used for both in situ flush and static preservation. We compared primary organ nonfunction and delayed graft function rates as well as blood creatinine levels in recipients of grafts processed with SCOT solution, versus University of Wisconsin solution (paired for age with the previous group) and with EuroCollins solution (historic data).
  
  
  RESULTS
  We observed delayed graft-function in 10% of the SCOT-processed group, 14% in the University of Wisconsin solution group, and 23% of the EuroCollins group. No case of primary organ nonfunction was reported. Creatinine levels in both SCOT and University of Wisconsin solution groups were similar. We did not observe any humoral or cellular graft rejection in the first 3 months after transplantation. In light of these preliminary results, the use of SCOT is safe for kidney preservation in the human setting. Further experience is warranted to assess the clinical consequences of its immunocamouflage properties as described in animal models.
authors.affiliation: Service d'Urologie, Hôpital Pitie-Salpetriere, 83 boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Billault
authors.forename: C
authors.initials: C
authors.lastname: Vaessen
authors.forename: E
authors.initials: E
authors.lastname: Van Glabeke
authors.forename: E
authors.initials: E
authors.lastname: Rolland
authors.forename: S
authors.initials: S
authors.lastname: Ourahma
authors.forename: L
authors.initials: L
authors.lastname: Dimitru
authors.forename: F
authors.initials: F
authors.lastname: Richard
authors.forename: M
authors.initials: M
authors.lastname: Eugène
authors.forename: B
authors.initials: B
authors.lastname: Barrou
mesh_terms: D000241:Adenosine; D000493:Allopurinol; D003404:Creatinine / Q000097:blood; D005602:France; D005978:Glutathione; D006801:Humans; D007328:Insulin; D007668:Kidney; D016030:Kidney Transplantation; D019188:Organ Preservation Solutions; D011092:Polyethylene Glycols; D011887:Raffinose
chemical_list: D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D011092:Polyethylene Glycols; D000493:Allopurinol; D003404:Creatinine; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose