6-Gingerol prevents cisplatin-induced acute renal failure in rats.
BACKGROUND
Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Recent evidence suggests that enhanced oxidative stress caused by oxygen-centered free radicals may contribute to the pathogenesis of cisplatin-induced acute renal failure. 6-Gingerol is claimed to be a potent antioxidant. The present study was performed to explore the renoprotective potential of 6-gingerol on cisplatin-induced oxidative stress and renal dysfunction.


METHODS
6-Gingerol in dosages of 12.5, 25, 50 mg/kg was administered 2 days before and 3 days after cisplatin administration. Renal injury was assessed by measuring serum creatinine, blood urea nitrogen, creatinine, urea clearance and serum nitrite levels. Renal oxidative stress was assessed by determining renal malondialdehyde levels, reduced glutathione levels and enzymatic activities of superoxide dismutase and catalase.


RESULTS
A single dose of cisplatin resulted in marked renal oxidative and nitrosative stress and significantly deranged renal functions. 6-Gingerol treatment significantly and dose-dependently restored renal functions, reduced lipid peroxidation and enhanced the levels of reduced glutathione and activities of superoxide dismutase and catalase.


CONCLUSIONS
The present study demonstrates the renoprotective potential of 6-gingerol against cisplatin-induced oxidative stress and renal dysfunction in rats. Hence, 6-gingerol has a potential to be used as therapeutic adjuvant in cisplatin nephrotoxicity.
Kuhad
Anurag
A
Pharmacology division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.
Tirkey
Naveen
N
Pilkhwal
Sangeeta
S
Chopra
Kanwaljit
K
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D002396:Catechols; D002945:Cisplatin / Q000633:toxicity*; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000494:pharmacology*; D005260:Female; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009153:Mutagens / Q000494:pharmacology*; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014508:Urea / Q000378:metabolism
D000970:Antineoplastic Agents; D000975:Antioxidants; D002396:Catechols; D005233:Fatty Alcohols; D009153:Mutagens; D009573:Nitrites; D008315:Malondialdehyde; D014508:Urea; C007845:gingerol; D003404:Creatinine; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D002945:Cisplatin