Mechanisms of disease: immunopathogenesis of celiac disease.
Celiac disease is a genetic inflammatory disorder with autoimmune components that is induced by the ingestion of dietary gluten. Refractory sprue and enteropathy-associated T-cell lymphoma are rare but distinctive complications of the disease. Although the importance of the adaptive immune response to gluten has been well established, observations now also point towards a central role for the gluten-induced innate stress response in the pathogenesis of celiac disease and its malignant complications.
Jabri
Bana
B
Department of Pathology, Medicine and Pediatrics, University of Chicago, IL 60637, USA. bjabri@bsd.uchicago.edu
Sollid
Ludvig M
LM
D002446:Celiac Disease / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D019204:GTP-Binding Proteins; D005903:Gliadin / Q000276:immunology / Q000378:metabolism; D006683:HLA-DQ Antigens / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000235:genetics / Q000378:metabolism
D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; C109756:HLA-DQ8 antigen; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins