Elastosis perforans serpiginosa in a patient with trisomy 21.
A 12-year-old girl with trisomy 21 (Downs syndrome) presented with an approximate 2-year history of an asymptomatic eruption on the right upper arm and left lateral neck that was clinically and histologically diagnostic of elastosis perforans serpiginosa (EPS). EPS is a perforating dermatosis affecting the face, ear, neck, extremities, or trunk. It occurs with greater frequency in persons with trisomy 21, as well as some other genetic syndromes and after D-penicillamine therapy. It has also been reported as a sporadic, presumably unrelated disorder in several acquired diseases.
Newman
Jeffrey S
JS
University of California at Davis, Department of Dermatology, USA. jeffrey.newman@ucdmc.ucdavis.edu
Fung
Maxwell A
MA
D002648:Child; D003240:Connective Tissue Diseases / Q000209:etiology / Q000473:pathology*; D004314:Down Syndrome / Q000150:complications*; D004547:Elastic Tissue / Q000473:pathology*; D004549:Elastin; D005260:Female; D006801:Humans; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology*
D004549:Elastin