Nothing in glycobiology makes sense, except in the light of evolution.
The remarkable structural diversity of glycans in nature, and their roles in cellular processes, host-pathogen interactions, biological diversity and speciation can be explained by evolutionary processes.
Varki
Ajit
A
Glycobiology Research and Training Center, Departments of Medicine and Cellular & Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. a1varki@ucsd.edu
D000818:Animals; D019143:Evolution, Molecular; D015971:Gene Expression Regulation, Enzymologic; D049810:Genetic Speciation; D006023:Glycoproteins / Q000378:metabolism*; D006031:Glycosylation; D016695:Glycosyltransferases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D009975:Orthomyxoviridae / Q000378:metabolism / Q000472:pathogenicity; D011134:Polysaccharides / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D021381:Protein Transport
D006023:Glycoproteins; D008562:Membrane Glycoproteins; D011134:Polysaccharides; D016695:Glycosyltransferases