title: Improved pharmacological properties for superoxide dismutase modified with beta-cyclodextrin-carboxymethylcellulose polymer.
abstract: Superoxide dismutase was glycosidated with cyclodextrin-branched carboxymethylcellulose. The modified enzyme contained 1.4 mol polymer per mol protein and retained 87% of the initial activity. The anti-inflammatory activity of superoxide dismutase was 2.2-times increased after conjugation and its plasma half-life time was prolonged from 4.8 min to 7.2 h.
authors.affiliation: Center for Enzyme Technology, University of Matanzas, Autopista a Varadero Km. 3.5, Matanzas, C.P. 44740, Cuba.
authors.forename: Aymara
authors.initials: A
authors.lastname: Valdivia
authors.forename: Yunel
authors.initials: Y
authors.lastname: Pérez
authors.forename: Hector
authors.initials: H
authors.lastname: Ramírez
authors.forename: Roberto
authors.initials: R
authors.lastname: Cao
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Villalonga
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D002266:Carboxymethylcellulose Sodium / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D002351:Carrageenan; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005528:Foot; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000493:pharmacokinetics*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; C516431:CMC-CD compound; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D002351:Carrageenan; D013482:Superoxide Dismutase; C031215:betadex; D002266:Carboxymethylcellulose Sodium