Anaphylaxis to cefazolin during labor secondary to prophylaxis for group B Streptococcus: a case report.
BACKGROUND
Anaphylaxis is an uncommon event during pregnancy, but if it does arise, it can lead to serious fetal consequences even if there are no serious long-term maternal complications.


METHODS
A parturient developed anaphylaxis in the labor unit shortly after intravenous cefazolin chemoprophylaxis had begun for perinatal group B streptococcal disease. Prompt treatment for anaphylaxis commenced, involving the administration of epinephrine and glucocorticoids, and an emergency cesarean section spared the mother serious morbidity, with a favorable perinatal outcome for the fetus.


CONCLUSIONS
To the best of our knowledge, this case is the first reported one of anaphylaxis to cefazolin in pregnancy secondary to prophylaxis against for B Streptococcus. The case demonstrates that a life-threatening anaphylactic reaction can occur at any time during pregnancy and that all staff in a maternal unit should be familiar with the management of perinatal anaphylaxis.
Jao
Mei-Shan
MS
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, 5, Fu-Shin Street, Kwei-Shan, Tao-Yuan, 333 Taiwan, ROC.
Cheng
Po-Jen
PJ
Shaw
Sheng-Wen
SW
Soong
Yung-Kuei
YK
D000328:Adult; D000707:Anaphylaxis; D000900:Anti-Bacterial Agents / Q000276:immunology* / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002437:Cefazolin / Q000276:immunology* / Q000627:therapeutic use; D002585:Cesarean Section; D004630:Emergencies; D005260:Female; D006801:Humans; D007744:Obstetric Labor Complications / Q000139:chemically induced* / Q000276:immunology; D011247:Pregnancy; D011256:Pregnancy Outcome; D013290:Streptococcal Infections / Q000188:drug therapy / Q000517:prevention & control*; D013292:Streptococcus agalactiae
D000900:Anti-Bacterial Agents; D002437:Cefazolin