title: Chromenes from Peperomia serpens (Sw.) Loudon (Piperaceae).
abstract: Chromatographic separation of the CH2Cl2 extract from leaves of Peperomia serpens yielded two chromenes [5-hydroxy-8-(3',7'-dimethylocta-2',6'-dienyl)-2,2,7-trimethyl-2H-1-chromene (1) and 5-hydroxy-8-(3'-methyl-2'-butenyl)-2,2,7-trimethyl-2H-1-chromene-6-carboxylic acid (2)], besides the known chromene [methyl 5-hydroxy-2,2,7-trimethyl-2H-1-chromene-6-carboxylate (3)] and the flavonoid, dihydrooroxylin (4). Their structural elucidation were achieved by spectroscopic analyses. The antifungal activities of the CH2Cl2 extract and the isolated chromenes were measured bioautographically against Cladosporium cladosporioides and C. sphaerospermum, when it was found that the crude extract showed higher activity as compared to the pure compounds.
authors.affiliation: Faculdade de Ciências Biológicas, Exatas e Experimentais, Universidade Presbiteriana Mackenzie, 01302-970 São Paulo - SP, Brazil.
authors.forename: Rodrigo O
authors.initials: RO
authors.lastname: Saga Kitamura
authors.forename: Paulete
authors.initials: P
authors.lastname: Romoff
authors.forename: Maria Cláudia M
authors.initials: MC
authors.lastname: Young
authors.forename: Massuo J
authors.initials: MJ
authors.lastname: Kato
authors.forename: João Henrique G
authors.initials: JH
authors.lastname: Lago
mesh_terms: D001578:Benzopyrans / Q000737:chemistry* / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D036941:Peperomia / Q000737:chemistry* / Q000378:metabolism
chemical_list: C516459:5-hydroxy-8-(3',7'-dimethylocta-2',6'-dienyl)-2,2,7-trimethyl-2H-1-chromene; C516460:5-hydroxy-8-(3'-methyl-2'-butenyl)-2,2,7-trimethyl-2H-1-chromene-6-carboxylic acid; D001578:Benzopyrans; D005419:Flavonoids; C516462:dihydrooroxylin; C516461:methyl 5-hydroxy-2,2,7-trimethyl-2H-1-chromene-6-carboxylate