title: The use of chitosan modified with glutaraldehyde and glyoxal as chromatographic support for the separation of flavonoids from Aleurites moluccana leaves.
abstract: This paper describes the preparation of chitosan modified with dialdehydes, glutaraldehyde (CH-Glu) and glyoxal (CH-Gly) and its application in the isolation of the flavonoids swertisin and 2"-O-rhamnosylswertisin from A. mollucana. The additional non-polar alkyl groups increase the hydrophobicity of the sorbent. The results show that the separation was mediated by hydrophobic interaction (CH-Glu), as well as hydrogen bonding, between phenolic OH or rhamnosil residues from the flavonoids, and the free amine groups (CH-Gly).
authors.affiliation: Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Curso de Farmácia/CCS, Universidade do Vale do Itajaí, Brasil.
authors.forename: M
authors.initials: M
authors.lastname: Morsch
authors.forename: L G J
authors.initials: LG
authors.lastname: Girardi
authors.forename: V
authors.initials: V
authors.lastname: Cechinel-Filho
authors.forename: C
authors.initials: C
authors.lastname: Meyre-Silva
authors.forename: C A
authors.initials: CA
authors.lastname: Rodrigues
mesh_terms: D031284:Aleurites / Q000737:chemistry*; D002240:Carbohydrate Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D048271:Chitosan / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D005976:Glutaral / Q000737:chemistry*; D006037:Glyoxal / Q000737:chemistry*; D006860:Hydrogen Bonding; D008969:Molecular Sequence Data
chemical_list: D005419:Flavonoids; D006037:Glyoxal; D048271:Chitosan; D005976:Glutaral