Cleavage of activated cyclic amines: Unprecedented approach toward 2-substituted cyclobutanones.
We report, for the first time, ring opening of activated four- to six-membered cyclic amines followed by an intramolecular expansion of cyclopropanol to cyclobutanone via carbocation intermediate. In the case of a N-tosylaziridine ester, a cyclobutanol was formed in a stereospecific manner during the Kulinkovich reaction step.
Baktharaman
Sivaraj
S
Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
Selvakumar
Sermadurai
S
Singh
Vinod K
VK