title: Systemic inflammatory markers and risk of dementia.
abstract: Inflammation plays an important role in the pathogenesis of Alzheimer's disease. This article reviews the results of prospective studies demonstrating that the level of systemic inflammation markers, particularly C-reactive protein and interleukin-6, can predict cognitive decline or dementia. The potential mechanisms linking systemic inflammatory molecules to cognitive decline are also discussed.
authors.affiliation: Department of Neurology, Jagiellonian University, Krakow, Poland. dziedzic@cm-uj.krakow.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dziedzic
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003704:Dementia / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D000514:alpha 1-Antichymotrypsin / Q000097:blood
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D000514:alpha 1-Antichymotrypsin; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein