The aryl hydrocarbon receptor and light.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been intensively studied with respect to the toxicity of xenobiotics. However, its function in response to light has never been summarized. Here, we provide an overview of AhR activation by light with a focus on the role of tryptophan in light-induced AhR activation. We discuss the involvement of the AhR in different biological rhythms and speculate on the possible role of the AhR in UV-induced responses in skin. Furthermore, this review points out future research needs in this field.
Rannug
Agneta
A
Karolinska Institute, Institute of Environmental Medicine, P.O. Box 210, S-171 77 Stockholm, Sweden. agneta.rannug@ki.se
Fritsche
Ellen
E
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D008024:Ligands; D018336:Receptors, Aryl Hydrocarbon / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects*; D014364:Tryptophan / Q000494:pharmacology / Q000528:radiation effects; D014466:Ultraviolet Rays
D051792:Basic Helix-Loop-Helix Proteins; D008024:Ligands; D018336:Receptors, Aryl Hydrocarbon; D014364:Tryptophan