Exploring the potential of N-methyl pyrrolidone as a cosurfactant in the microemulsion systems.
The effect of N-methyl pyrrolidone (NMP) on the phase behavior of two ternary systems, viz. PEG-35-castor oil (CremophoreEL)-glyceryl caprylate/caprate (Capmul MCM)-water and PEG-35-castor oil (CremophoreEL)-isopropyl myristate-water was studied. The study indicated that NMP has considerable influence on the phase behavior of both the systems. NMP increased the area of microemulsion formation in both the systems. Moreover, it also led to reduction/disappearance in the gelling region of the CremophoreEL-isopropyl myristate-water system. These observations allowed us to conclude that NMP can be considered as a cosurfactant for the development of biocompatible microemulsions.
Bachhav
Y G
YG
Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology, Matunga, Mumbai 400019, India.
Date
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Patravale
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D002626:Chemistry, Pharmaceutical / Q000379:methods; D004339:Drug Compounding; D004655:Emulsions; D005782:Gels; D007700:Kinetics; D011092:Polyethylene Glycols / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
D004655:Emulsions; D005782:Gels; D011760:Pyrrolidinones; D013501:Surface-Active Agents; D014867:Water; D011092:Polyethylene Glycols; C038678:N-methylpyrrolidone