Cytotoxic constituents from Butea superba Roxb.
A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC(50) (microM) values of 37.3+/-2.5 and 71.1+/-0.8 and on BC cell lines with IC(50) (microM) values of 32.7+/-1.5 and 47.3+/-0.3, respectively.
Ngamrojanavanich
Nattaya
N
Research Centre for Bioorganic Chemistry, Faculty of Science, Chulalongkorn University, Pyathai Road, Pathumwan, Bangkok, Thailand. nnattaya@chula.ac.th
Loontaisong
Aimon
A
Pengpreecha
Somchai
S
Cherdshewasart
Wichai
W
Pornpakakul
Surachai
S
Pudhom
Khanitha
K
Roengsumran
Sophon
S
Petsom
Amorn
A
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D031290:Butea / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology; D008518:Medicine, East Asian Traditional; D036343:Pterocarpans / Q000737:chemistry / Q000494:pharmacology; D013785:Thailand; D000094162:Phytoalexins
D000972:Antineoplastic Agents, Phytogenic; D007529:Isoflavones; D036343:Pterocarpans; C083295:prunetin; C007768:formononetin; C047353:medicarpin; D000094162:Phytoalexins