title: No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.
abstract: Most genetic association studies in bipolar disorder have focussed on genes involved in major neurotransmitter systems or brain development. Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val158Met) and dopamine D3 receptor (Ser9Gly) genes have all been associated with bipolar disorder. We aimed at investigating whether these functional variants contribute to the genetic etiology of bipolar disorder in a northern Swedish isolated population. Moreover, we wanted to gain information about the synergistic contribution of these functional variants. Neither of these functional polymorphisms was associated with bipolar disorder in the northern Swedish patient-control sample nor did we find evidence of gene-gene interaction. Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.
authors.affiliation: Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerp, Belgium.
authors.forename: Ann
authors.initials: A
authors.lastname: Van Den Bogaert
authors.forename: Kristel
authors.initials: K
authors.lastname: Sleegers
authors.forename: Sonia
authors.initials: S
authors.lastname: De Zutter
authors.forename: Lien
authors.initials: L
authors.lastname: Heyrman
authors.forename: Karl-Fredrik
authors.initials: KF
authors.lastname: Norrback
authors.forename: Rolf
authors.initials: R
authors.lastname: Adolfsson
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
mesh_terms: D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D050637:Receptors, Dopamine D3 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D013548:Sweden
chemical_list: D050637:Receptors, Dopamine D3; D050486:Serotonin Plasma Membrane Transport Proteins; D002394:Catechol O-Methyltransferase