title: Small cell lung carcinoma presenting as collapsin response-mediating protein (CRMP) -5 paraneoplastic optic neuropathy.
abstract: A 77-year-old woman presenting with progressive visual loss in both eyes was found to have small cell lung cancer. Assay for collapsin response-mediating protein (CRMP) -5 was positive suggesting a paraneoplastic optic neuropathy (PON). During treatment of the small cell lung cancer, the patient died of pneumonia and autopsy disclosed neuropathologic abnormalities consistent with PON. This is only the second case of CRMP-5-confirmed PON to report neuropathologic findings.
authors.affiliation: Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium.
authors.forename: Rishi
authors.initials: R
authors.lastname: Sheorajpanday
authors.forename: Hans
authors.initials: H
authors.lastname: Slabbynck
authors.forename: Wivine
authors.initials: W
authors.lastname: Van De Sompel
authors.forename: Danny
authors.initials: D
authors.lastname: Galdermans
authors.forename: Ingrid
authors.initials: I
authors.lastname: Neetens
authors.forename: Peter Paul
authors.initials: PP
authors.lastname: De Deyn
mesh_terms: D000368:Aged; D000912:Antibodies, Neoplasm / Q000097:blood; D018288:Carcinoma, Small Cell / Q000150:complications*; D005260:Female; D006801:Humans; D006867:Hydrolases; D008279:Magnetic Resonance Imaging / Q000379:methods; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism*; D009901:Optic Nerve Diseases / Q000378:metabolism*; D020364:Paraneoplastic Polyneuropathy / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D040121:Semaphorin-3A / Q000378:metabolism*
chemical_list: D000912:Antibodies, Neoplasm; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D040121:Semaphorin-3A; C415087:DPYSL5 protein, human; D006867:Hydrolases