title: Bitterness suppression of BCAA solutions by L-ornithine.
abstract: The purpose of the present study was to evaluate the bitterness-suppressing effect of L-ornithine (L-Orn) on single or mixed solutions of branched-chain amino acids (BCAAs) using human gustatory sensation tests and an artificial taste sensor. The BCAAs tested (L-isoleucine (L-Ile), L-leucine (L-Leu), and L-valine (L-Val)) are the main components of various enteral nutrients or supplements. The bitterness-suppression effect of L-Orn was also compared with the effect of L-Arg. L-Orn was effective in suppressing the bitterness of single or mixed solutions of BCAAs in human gustatory sensation tests, the effect being similar to or greater than that of L-Arg. The artificial taste sensor was able to predict the bitterness-suppressing effects of L-Orn and L-Arg. The response electric potential patterns of L-Val, L-Leu and L-Ile solutions to which 100 mM L-Arg had been added were quite similar to the sensor response patterns of the 100 mM L-Arg solutions alone. The relative response electric potential patterns of L-Val, L-Leu or L-Ile solutions containing 100 mM L-Orn in channels 5-8 (positively charged) are similar to that of single solution of 100 mM L-Orn.
authors.affiliation: School of Pharmaceutical Science, Mukogawa Women's University, 11-68 Koshien, 9-Bancho, Nishinomiya, Hyogo 663-8179, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Tokuyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shibasaki
authors.forename: Hideo
authors.initials: H
authors.lastname: Kawabe
authors.forename: Junji
authors.initials: J
authors.lastname: Mukai
authors.forename: Sachie
authors.initials: S
authors.lastname: Okada
authors.forename: Takahiro
authors.initials: T
authors.lastname: Uchida
mesh_terms: D000597:Amino Acids, Branched-Chain / Q000737:chemistry*; D001120:Arginine / Q000737:chemistry; D006801:Humans; D009952:Ornithine / Q000737:chemistry* / Q000494:pharmacology; D011803:Quinine / Q000737:chemistry / Q000378:metabolism; D012680:Sensitivity and Specificity; D012996:Solutions / Q000737:chemistry; D013649:Taste / Q000187:drug effects
chemical_list: D000597:Amino Acids, Branched-Chain; D012996:Solutions; D001120:Arginine; D011803:Quinine; D009952:Ornithine