Effect of drug type on the degradation rate of PLGA matrices.
We compare the rate of drug release through the degradation of 50:50 polylactic-co-glycolic acid polymer pellets, for six different drugs: Thiothixene, Haloperidol, Hydrochlorothiozide, Corticosterone, Ibuprofen, and Aspirin. Despite using the same polymer matrix and drug loading (20% by weight), we find that the rate of polymer degradation and the drug release profile differ significantly between the drugs. We conclude that the design of biodegradable polymeric drug carriers with high drug loadings must account for the effect of the drug on the polymer degradation and drug release rate.
Siegel
Steven J
SJ
Stanley Center for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA.
Kahn
Jonathan B
JB
Metzger
Kayla
K
Winey
Karen I
KI
Werner
Kathryn
K
Dan
Nily
N
D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D014150:Antipsychotic Agents / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D003345:Corticosterone / Q000737:chemistry; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers; D006220:Haloperidol / Q000737:chemistry; D006852:Hydrochlorothiazide / Q000737:chemistry; D006868:Hydrolysis; D007052:Ibuprofen / Q000737:chemistry; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008956:Models, Chemical; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013888:Thiothixene / Q000737:chemistry; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D014150:Antipsychotic Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D006852:Hydrochlorothiazide; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D013888:Thiothixene; D006220:Haloperidol; D001241:Aspirin; D003345:Corticosterone; D007052:Ibuprofen