Relationship between serum prostate-specific antigen levels and body mass index in healthy younger men.
OBJECTIVE
To understand further the physiologic characteristics of serum prostate-specific antigen (PSA) concentrations in healthy younger men.


METHODS
A total of 2032 men, 20 to 39 years old, who visited our hospital for a routine health checkup were entered into the study. Pearson correlation coefficients were determined to evaluate the association between serum PSA and clinical parameters. Because of the log-normal distribution, the serum PSA levels were log-transformed for analysis.


RESULTS
Although the relationships were weak, significant negative correlations were noted between serum PSA and body weight (r = -0.107, P <0.001), body mass index (BMI; r = -0.131, P <0.001), aspartate aminotransferase (AST; r = -0.076, P = 0.001), alanine aminotransferase (ALT; r = -0.079, P = 0.001), gamma-glutamyltransferase (r = -0.046, P = 0.046), and creatinine clearance (r = -0.113, P <0.001). A positive correlation was found between serum PSA and creatinine (r = 0.053, P = 0.024). Age did not correlate with serum PSA level. The influence of clinical parameters on serum PSA was explored using multiple linear regression analysis. Using the stepwise method, all other explanatory variables, except BMI, AST, and creatinine were eliminated (log10[PSA] = -0.124[BMI] + 0.063[creatinine] - 0.053[AST] + 0.097; r = 0.152, P <0.001).


CONCLUSIONS
BMI, creatinine, and AST may influence the serum PSA level in this population. However, because it was not clear that this group should be considered at high risk of prostate cancer in the future, additional longitudinal research is needed.
Ahn
Jae Ouk
JO
Department of Medical Informatics, Soonchunhyang University School of Medicine, Seoul, Korea.
Ku
Ja Hyeon
JH
D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*
D017430:Prostate-Specific Antigen