Outbreak of infection by carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium.
Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 17 patients between September 2004 and August 2005 at the Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium. These multidrug-resistant isolates, which belonged to a single clone, remained susceptible to colistin and tigecycline only and produced the carbapenem-hydrolyzing oxacillinase OXA-58. This study highlights the importance of the intercountry spread of this beta-lactamase-mediated resistance mechanism and its epidemic evolution.
Bogaerts
Pierre
P
Laboratoire de Bactériologie, Cliniques Universitaires UCL de Mont-Godinne, 1, Av. Dr Gaston Thérasse, B-5530 Yvoir, Belgium. pierre.bogaerts@mont.ucl.ac.be
Naas
Thierry
T
Wybo
Ingrid
I
Bauraing
Caroline
C
Soetens
Oriane
O
Piérard
Denis
D
Nordmann
Patrice
P
Glupczynski
Youri
Y
D000151:Acinetobacter Infections / Q000453:epidemiology*; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D000328:Adult; D000368:Aged; D001530:Belgium / Q000453:epidemiology; D015780:Carbapenems / Q000494:pharmacology*; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D001618:beta-Lactamases / Q000096:biosynthesis*
D015780:Carbapenems; D001618:beta-Lactamases; C509061:beta-lactamase OXA-58, Acinetobacter junii