[Effect of yuquan pill on proinflammatory cytokines in patients with type 2 diabetes mellitus].
OBJECTIVE
To observe the effect of Yuquan Pill (YP) on proinflammatory cytokines in patients with type 2 diabetes mellitus (DM2).


METHODS
Ninety patients with DM2 were randomly divided into the treated group and the control group by the ratio of 2:1. Both groups were treated with Glucobay on the base of dietary and exercise therapy for 3 months, with YP, given to the treated group additionally 6 g four times a day. And the changes of proinflammatory cytokines, including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), etc. were observed.


RESULTS
The levels of serum CRP,TNF-alpha and IL-6 significantly lowered after treatment in both groups (P<0.01), and the improvement in the treated group was superior to that in the control group (P<0.01).


CONCLUSIONS
YP could reduce the levels of the increased proinflammatory cytokines in patients with DM2.
Deng
Yin-quan
YQ
The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003. deyq@tom.com
Fan
Xiao-fen
XF
Wu
Guo-lin
GL
D020909:Acarbose / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D020909:Acarbose