title: Evaluating brain activity in obsessive-compulsive disorder: preliminary insights from a multivariate analysis.
abstract: Obsessive-compulsive disorder (OCD) has been linked to a dysfunction of brain corticostriatal networks, although functional imaging studies of OCD rarely apply network-sensitive analysis methods. In this study, we compared a univariate and a multivariate analysis of PET data in OCD patients and healthy subjects; the latter approach was considered more suitable for characterizing functional networks of brain activity. Although both methods suggested there was abnormal corticostriatal activity in OCD patients, the nature, extent and magnitude of this activity was clearly enhanced by the multivariate approach. Implications for the analysis of such studies are discussed.
authors.affiliation: Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia. habj@unimelb.edu.au
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Harrison
authors.forename: Murat
authors.initials: M
authors.lastname: Yücel
authors.forename: Marnie
authors.initials: M
authors.lastname: Shaw
authors.forename: Michael
authors.initials: M
authors.lastname: Kyrios
authors.forename: Paul
authors.initials: P
authors.lastname: Maruff
authors.forename: Warrick J
authors.initials: WJ
authors.lastname: Brewer
authors.forename: Rosemary
authors.initials: R
authors.lastname: Purcell
authors.forename: Dennis
authors.initials: D
authors.lastname: Velakoulis
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Strother
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Scott
authors.forename: Pradeep J
authors.initials: PJ
authors.lastname: Nathan
authors.forename: Christos
authors.initials: C
authors.lastname: Pantelis
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000378:metabolism; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000378:metabolism* / Q000523:psychology; D049268:Positron-Emission Tomography; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires