Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma.
OBJECTIVE
To describe immunohistochemical features encountered in ovarian fibrothecoma with correlation to clinical presentation and surgical management.


METHODS
A female age 75 presented for evaluation of melena. The patient reported total abdominal hysterectomy and removal of both ovaries 40 years earlier.


RESULTS
CA-125 was normal and there was no evidence of hyperestrogen effect. Pelvic CT revealed a partially calcified 7 cm pelvic mass without adenopathy or ascites; ultrasound was confirmatory. Endoscopy identified three benign intestinal tubular adenomas. Following laparoscopic excision of the pelvic tumor immunohistochemical analysis of the mass showed negative staining for keratin, S100 protein, inhibin, calretinin, melan A, smooth muscle actin, CD34, CD117, and desmin. The tissue was positive for vimentin, however.


CONCLUSIONS
Ovarian fibrothecomas represent an ovarian stromal neoplasm developing in a wide spectrum of clinical settings. Particularly if oophorectomy is stated to have been performed remote from the time of index presentation, the status of the ovaries must be considered whenever pelvic pathology is encountered. We describe a calcified ovarian fibrothecoma identified during gastroenterology investigation and confirmed immunohistochemically via high amplitude vimentin signal.
Sills
Eric Scott
ES
Department of Obstetrics, Gynecology & Reproductive Research, Murphy Medical Center, Murphy, NC, USA. drsills@murphywomenscenter.com
Doan
Terrence B
TB
Mock
R James
RJ
Dixson
George R
GR
Rohlfing
Michael B
MB