Sildenafil reduces postoperative adhesion formation in a rat uterine horn model.
OBJECTIVE
The purpose of this experimental study was to evaluate the effect of oral sildenafil on postoperative adhesion formation in rats.


METHODS
Thirty-two Wistar Albino rats were subjected to standardized lesion by cauterization of the uterine horn and abrasion of the adjacent parietal peritoneum. They were randomized to receive sildenafil at a daily dose of 15 mg/kg, 7.5mg/kg and 3.75 mg/kg or placebo. Sildenafil was administered by gavage 1h before the operation and daily for 5 days after the procedure. The extent and severity of adhesions were assessed on the 14th postoperative day.


RESULTS
The severity but not extent of adhesions in rats given 15 mg/kg sildenafil was significantly less when compared with the other groups (<0.001).


CONCLUSIONS
Sildenafil diminishes peritoneal adhesion formation in rat.
Batukan
Cem
C
Erciyes University, School of Medicine, Department of Obstetrics and Gynecology, Gevher Neshibe Hospital, 38039 Kayseri, Turkey. cbatukan@erciyes.edu.tr
Ozgun
Mahmut T
MT
Basbug
Mustafa
M
Muderris
Iptisam I
II
D000818:Animals; D005260:Female; D007813:Laparotomy; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000068677:Sildenafil Citrate; D018709:Statistics, Nonparametric; D013450:Sulfones / Q000494:pharmacology*; D000267:Tissue Adhesions / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery*
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate