Plasma eosinophil cationic protein, interleukin-5, and ECP/Eo count ratio in patients with various eosinophilic diseases.
Hypereosinophilia is associated with clonal disorders, reactive conditions, and rarely with idiopathic hypereosinophilic syndrome (IHES). We investigated whether measurement of eosinophilic activity using the plasma eosinophil cationic protein (ECP) level, interleukin-5 (IL-5) level, and the ratio of eosinophilic cationic protein/eosinophil count (ECP/Eo) could improve the early differentiation among various eosinophilic diseases: IHES (n = 9), clonal disorder (n = 35), reactive eosinophilia with malignancy (n = 30), and reactive eosinophilia with inflammation (n = 46). The 120 eosinophilic patients had higher plasma ECP and IL-5 levels than the non-eosinophilic control group (p <0.05). The 9 patients with IHES had significantly higher plasma ECP and IL-5 levels than patients with other eosinophilic diseases (p <0.05). The plasma levels of ECP and the ECP/Eo ratio were higher in patients with non-haematologic malignancy than in those with other reactive eosinophilias (p <0.05). This study shows that levels of plasma ECP, IL-5, and ECP/Eo ratio may assist in the clinical differentiation of various eosinophilic diseases.
Park
Yeon-Joon
YJ
Department of Laboratory Medicine, College of Medicine, Catholic University of Korea, 505 Banpo-dong Seocho-ku, Seoul, 137-040, Korea (South).
Oh
Eun-Jee
EJ
Park
Jong-Won
JW
Kim
Myungshin
M
Han
Kyungja
K
D015415:Biomarkers / Q000097:blood; D001856:Bone Marrow Examination / Q000379:methods; D047150:Eosinophil Cationic Protein / Q000097:blood*; D004802:Eosinophilia / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D015848:Interleukin-5 / Q000097:blood / Q000378:metabolism*
D015415:Biomarkers; D015848:Interleukin-5; D047150:Eosinophil Cationic Protein