title: Comparison of clinical features of acute hepatitis caused by hepatitis E virus (HEV) genotypes 3 and 4 in Sapporo, Japan.
abstract: In Japan, indigenous acute hepatitis E is not a rare disease, and is mainly caused by hepatitis E virus (HEV) genotypes 3 and 4. Whether there is a difference in clinical features between the two genotypes remains unclear. This study compares the clinical features of patients infected with the two. From January, 1994, to December, 2003, 9 infected with HEV genotype 3 and 27 patients with genotype 4 were enrolled. Patients with genotype 4 had significantly higher peak alanine aminotransferase levels (median 3430IU/L, interquartile range 1747-4763 versus 1052IU/L, 845-2707; p=0.01). The lowest prothrombin time was lower in the genotype 4 group (61%, 42-77 versus 84%, 70-96; p=0.05). In our series, patients with genotype 4 had longer median duration of hospital stay (26.5 days, 18-31 versus 18 days, 12-23.5; p=0.06). The patients with genotype 4 infection tended to have more severe clinical manifestations than those with genotype 3 infection.
authors.affiliation: Department of Internal Medicine, Teine Keijinkai Hospital, Sapporo 006-8555, Japan.
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Ohnishi
authors.forename: Jong-Hon
authors.initials: JH
authors.lastname: Kang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maekubo
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Arakawa
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Karino
authors.forename: Joji
authors.initials: J
authors.lastname: Toyota
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shunji
authors.initials: S
authors.lastname: Mishiro