Treatment of viral and neoplastic diseases with double-stranded RNA derivatives and other new agents.
Many attempts have been made to inhibit viral and neoplastic diseases by targeting the RNA system. The pathophysiologic significance of the microRNA system and the therapeutic potential of its manipulation are discussed. Studies of double-stranded RNA derivatives are reviewed. The therapeutic potential of one of these compounds, polyI:MPC, is emphasized. Studies of other related antiviral and antineoplastic agents are discussed, including 2'-deoxyoligocytidilates and telomerase inhibitors.
Ambrus
Julian L
JL
Department of Internal Medicine, State University of New York at Buffalo, Buffalo General Hospital/Kaleida Health System, 100 High Street, Buffalo, NY 14203, USA. jlambrus@netscape.net
Chadha
Kailash C
KC
Islam
Anwarul
A
Akhter
Selina
S
Ambrus
Julian L
JL
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D011070:Poly I-C / Q000627:therapeutic use; D034622:RNA Interference / Q000502:physiology; D012330:RNA, Double-Stranded / Q000627:therapeutic use*; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000187:drug effects; D014777:Virus Diseases / Q000628:therapy*
D004791:Enzyme Inhibitors; D012330:RNA, Double-Stranded; D019098:Telomerase; D011070:Poly I-C