title: Synthesis, structure and biological activity of cobalt(II) and copper(II) complexes of valine-derived schiff bases.
abstract: We have synthesized two cobalt(II) 2 and copper(II) 3 complexes of valine-derived Schiff bases. The obtained complexes were characterized by elemental analysis, FT-IR and X-ray diffraction. Biological studies of complexes 2 and 3 had been carried out in vitro for antimicrobial activity against Gram-positive, Gram-negative bacteria and human pathogenic fungi. Compound 3 was proven to be a broad spectrum agent, showed a significant inhibition of the growth of Gram-positive bacteria (Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, Micrococcus luteus), and pathogenic fungi (Candida spp., Cryptococcus neoformans, Rhodothece glutinis, Saccharomyces cerevisia, Aspergillus spp., Rhizopus nigricans) tested and a moderate activity against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris and Enterobacter aerogenes) tested. The in vitro cytotoxicity of compound 3 was evaluated using hemolytic assay, in which the compound 3 was found to be non-toxic to human erythrocytes even at a concentration of 500mug/mL.
authors.affiliation: Department of Chemistry, The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Lv
authors.forename: Tingting
authors.initials: T
authors.lastname: Liu
authors.forename: Sulan
authors.initials: S
authors.lastname: Cai
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001419:Bacteria / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D008956:Models, Chemical; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry*; D014633:Valine / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D014633:Valine