Sex differences in amphetamine-induced displacement of [(18)F]fallypride in striatal and extrastriatal regions: a PET study.
OBJECTIVE
The authors examined gender differences in d-amphetamine-induced displacements of [(18)F]fallypride in the striatal and extrastriatal brain regions and the correlations of these displacements with cognition and sensation seeking.


METHODS
Six women and seven men underwent positron emission tomography (PET) with [(18)F]fallypride before and after an oral dose of d-amphetamine. Percent displacements were calculated using regions of interest and parametric images of dopamine 2 (D(2)) receptor binding potential.


RESULTS
Parametric images of dopamine release suggest that the female subjects had greater dopamine release than the male subjects in the right globus pallidus and right inferior frontal gyrus. Gender differences were observed in correlations of changes in cognition and sensation seeking with regional dopamine release.


CONCLUSIONS
Findings revealed a greater dopamine release in women as well as gender differences in the relationship between regional dopamine release and sensation seeking and cognition.
Riccardi
Patrizia
P
Vanderbilt University Medical Center, Department of Radiology, Nashville, TN 37232-2675, USA. pitrizia.riccardi@vanderbilt.edu
Zald
David
D
Li
Rui
R
Park
Sohee
S
Ansari
M Sib
MS
Dawant
Benoit
B
Anderson
Sharlet
S
Woodward
Neil
N
Schmidt
Dennis
D
Baldwin
Ronald
R
Kessler
Robert
R
D000284:Administration, Oral; D000328:Adult; D001549:Benzamides / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D003071:Cognition / Q000187:drug effects; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes / Q000378:metabolism*; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D005917:Globus Pallidus / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010551:Personality / Q000187:drug effects; D010552:Personality Assessment; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data*; D011759:Pyrrolidines / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D012737:Sex Factors
D001549:Benzamides; D005462:Fluorine Radioisotopes; C094948:N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; D011759:Pyrrolidines; D011954:Receptors, Dopamine; D003913:Dextroamphetamine; D004298:Dopamine