title: Comparative effects of estradiol, raloxifene, and genistein on the uterus of ovariectomized mice.
abstract: To explore the uterine effects of administration of compounds that exert their bone-sparing functions through estrogen receptors, we administered 17beta-E2, raloxifene, or genistein to ovariectomized mice and analyzed the uterus weight and histology 4 weeks after beginning the treatments. Results indicated that raloxifene and genistein have partial agonistic properties on the uterus in estrogen-depleted mice, and that genistein induced apoptosis and several atypias in the glandular epithelium of endometrium, as demonstrated in hematoxylin-eosin-stained histological sections.
authors.affiliation: Research Unit, Hospital Clínico Universitario of Valencia, Valencia, Spain. migarpe@uv.es
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: García-Pérez
authors.forename: Rosa
authors.initials: R
authors.lastname: Noguera
authors.forename: Raquel
authors.initials: R
authors.lastname: del Val
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Noguera
authors.forename: Carlos
authors.initials: C
authors.lastname: Hermenegildo
authors.forename: Antonio
authors.initials: A
authors.lastname: Cano
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D019833:Genistein / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010052:Ovariectomy; D020849:Raloxifene Hydrochloride / Q000494:pharmacology*; D014599:Uterus / Q000166:cytology* / Q000187:drug effects*
chemical_list: D020849:Raloxifene Hydrochloride; D004958:Estradiol; D019833:Genistein