A naturally occurring novel allele of Escherichia coli outer membrane protein A reduces sensitivity to bacteriophage.
A novel Escherichia coli outer membrane protein A (OmpA) was discovered through a proteomic investigation of cell surface proteins. DNA polymorphisms were localized to regions encoding the protein's surface-exposed loops which are known phage receptor sites. Bacteriophage sensitivity testing indicated an association between bacteriophage resistance and isolates having the novel ompA allele.
Power
Michelle L
ML
Department of Biological Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia. mpower@els.mq.edu.au
Ferrari
Belinda C
BC
Littlefield-Wyer
Jane
J
Gordon
David M
DM
Slade
Martin B
MB
Veal
Duncan A
DA
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001315:Australia; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D003090:Coliphages / Q000502:physiology*; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification / Q000821:virology*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D008394:Marsupialia; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; C078167:OMPA outer membrane proteins