title: Cerebrospinal fluid analysis and magnetic resonance imaging in the diagnosis of neurologic disease in dogs: a retrospective study.
abstract: BACKGROUND
  Diagnosis of central nervous system (CNS) abnormalities in dogs can be challenging antemortem. Historically, cerebrospinal fluid (CSF) analysis has been used for routine diagnostic evaluation of animals with suspected neurologic disease; however, with increasing availability of magnetic resonance (MR) imaging, the need for concurrent CSF analysis may be questioned.
  
  
  OBJECTIVE
  The purpose of this study was to retrospectively assess and compare the diagnostic information contributed from MR imaging and CSF analysis in a population of dogs presenting with neurologic disease.
  
  
  METHODS
  Results of concurrent MR imaging and CSF analysis were evaluated in dogs presented for neurologic diseases. Based on clinical diagnosis, the sensitivity of CSF analysis and MR imaging for detecting a nervous system abnormality was calculated. Dogs with diagnoses confirmed by other diagnostic modalities were also evaluated separately.
  
  
  RESULTS
  A total of 256 dogs were included in the study. For clinical diagnoses in which abnormalities were expected, MR imaging abnormalities were found in 89% and CSF abnormalities in 75% of dogs; CSF abnormalities were more common than MR imaging abnormalities only in inflammatory CNS disease. The majority of CSF abnormalities were nonspecific; an etiologic diagnosis was determined in only 2% of CSF samples. MR imaging excelled in detecting structural disorders, revealing 98% of vertebral abnormalities. In confirmed cases (n = 55), 76% of MR images and 9% of CSF samples were diagnostic. When intervertebral disk disease (IVDD) and vertebral malformation were excluded from analysis (n = 16 remaining), 25% of MR images and 6% of CSF cytology results were highly indicative of the confirmed diagnoses; CSF titer results provided the diagnosis in 25% of these cases.
  
  
  CONCLUSIONS
  CSF analysis may not be necessary when MR findings of IVDD or vertebral malformation/instability are obvious; however, when the cause of neurologic disorder is uncertain, concurrent MR imaging and CSF analysis provides the greatest assistance in establishing a clinical diagnosis.
authors.affiliation: Department of Veterinary Clinical Sciences, Washington State University, College of Veterinary Medicine, Pullman, WA, USA. andrea.bohn@colostate.edu
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Bohn
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Wills
authors.forename: Chadwick L
authors.initials: CL
authors.lastname: West
authors.forename: Russell L
authors.initials: RL
authors.lastname: Tucker
authors.forename: Rodney S
authors.initials: RS
authors.lastname: Bagley
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002452:Cell Count / Q000662:veterinary; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D002555:Cerebrospinal Fluid / Q000737:chemistry* / Q000166:cytology*; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000662:veterinary*; D009460:Neurologic Examination / Q000662:veterinary; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D002556:Cerebrospinal Fluid Proteins