Role of centrifugal projections to the olfactory bulb in olfactory processing.
While there is evidence that feedback projections from cortical and neuromodulatory structures to the olfactory bulb are crucial for maintaining the oscillatory dynamics of olfactory bulb processing, it is not clear how changes in dynamics are related to odor perception. Using electrical lesions of the olfactory peduncle, sparing output from the olfactory bulb while decreasing feedback inputs to the olfactory bulb, we demonstrate here a role for feedback inputs to the olfactory bulb in the formation of odor-reward associations, but not for maintaining primary bulbar odor representations, as reflected by spontaneous odor discrimination.
Kiselycznyk
Carly L
CL
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York, USA.
Zhang
Steven
S
Linster
Christiane
C
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology; D005246:Feedback / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D012686:Septal Nuclei / Q000166:cytology / Q000502:physiology; D012903:Smell / Q000502:physiology*