Does transforming growth factor-beta1 predict for radiation-induced pneumonitis in patients treated for lung cancer?
The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpoint of grade > or =1 RP, those with V30>30% and an end-RT/baseline TGF-beta1 ratio> or =1 had a significantly higher incidence of RP than did those with V30>30% and an end-RT/baseline TGF-beta1 ratio<1. For most other patient groups, there were no clear associations between TGF-beta1 values and rates of RP. These findings suggest that TGF-beta1 is generally not predictive for RP except for the group of patients with a high V30.
Evans
Elizabeth S
ES
Department of Radiation Oncology, Duke University Medical Center, Box 3085, Durham, NC 27710, USA. evans139@email.unc.edu
Kocak
Zafer
Z
Zhou
Su-Min
SM
Kahn
Daniel A
DA
Huang
Hong
H
Hollis
Donna R
DR
Light
Kim L
KL
Anscher
Mitchell S
MS
Marks
Lawrence B
LB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology* / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D017564:Radiation Pneumonitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011879:Radiotherapy Dosage; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood*
D053773:Transforming Growth Factor beta1