title: Effects of dietary D-psicose on diurnal variation in plasma glucose and insulin concentrations of rats.
abstract: The effects of supplemental D-psicose in the diet on diurnal variation in plasma glucose and insulin concentrations were investigated in rats. Forty-eight male Wistar rats were divided into four groups. Each group except for the control group was fed a diet of 5% D-fructose, D-psicose, or psico-rare sugar (3:1 mixture of D-fructose and D-psicose) for 8 weeks. Plasma glucose levels were lower and plasma insulin levels were higher at all times of day in the psicose and psico-rare sugar groups than in the control and fructose groups. Weight gain was significantly lower in the psicose group than in the control and fructose groups. Liver glycogen content, both before and after meals was higher in the psicose group than in the control and fructose groups. These results suggest that supplemental D-psicose can lower plasma glucose levels and reduce body fat accumulation. Hence, D-psicose might be useful in preventing postprandial hyperglycemia in diabetic patients.
authors.affiliation: Faculty of Agriculture, Kagawa University, Ikenobe, Kagawa, Japan. matsuo@ag.kagawa-u.ac.jp
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Matsuo
authors.forename: Ken
authors.initials: K
authors.lastname: Izumori
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D004040:Dietary Carbohydrates / Q000378:metabolism*; D002149:Energy Intake / Q000187:drug effects; D005632:Fructose / Q000378:metabolism* / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; C003243:psicose; D005632:Fructose; D006003:Glycogen