title: The association of neuroleptic sensitivity in Lewy body disease with a false positive clinical diagnosis of Creutzfeldt-Jakob disease.
abstract: BACKGROUND
  Dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) share clinical features like cognitive decline, motor disturbances en psychiatric symptoms. Overlapping symptoms may cause physicians to mistake DLB for CJD.
  
  
  METHODS
  Clinical data of 12 patients with autopsy-confirmed DLB who had been clinically suspected to suffer from CJD were analysed to investigate possible clinical features which led to misdiagnosis.
  
  
  RESULTS
  There was an association in time between administering neuroleptics and rapid clinical deterioration in 8 out of 9 patients.
  
  
  CONCLUSIONS
  It is suggested that the neuroleptic sensitivity in LBD fuelled the misdiagnosis of CJD in the presented series. Diagnostic confusion between CJD and DLB may have important clinical consequences and may lead to treatment restrictions.
authors.affiliation: Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands. a.w.lemstra@amc.uva.nl
authors.forename: A W
authors.initials: AW
authors.lastname: Lemstra
authors.forename: N
authors.initials: N
authors.lastname: Schoenmaker
authors.forename: A J M
authors.initials: AJ
authors.lastname: Rozemuller-Kwakkel
authors.forename: W A
authors.initials: WA
authors.lastname: van Gool
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D003951:Diagnostic Errors / Q000517:prevention & control*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012189:Retrospective Studies
chemical_list: D014150:Antipsychotic Agents