Genetic variations in benzene metabolism and susceptibility to multiple myeloma.
We have previously shown that deficiency in the biotransformation enzyme glutathione-S-transferase theta (GSTT1) is a risk factor for multiple myeloma (MM). The present case-control study of 102 MM patients and 205 controls revealed a significant trend in increasing risk of MM with inheritance of multiple putative 'high risk' genetic variants in related pathways of benzene detoxification. Individuals who carried polymorphisms for GSTT1 null and/or high activity microsomal epoxide hydrolase (mEH 113YY+139HR or 113YY+139RR or 113YH+139RR) and/or low activity NAD(P)H:quinone oxidoreductase 1 (NQO1 187PS/SS) were 1.65, 2.49 and 13 times more likely to have MM (P(trend)=0.001).
Lincz
Lisa F
LF
Hunter Haematology Research Group, Newcastle Mater Misericordiae Hospital, Edith Street, Waratah, NSW 2298, Australia. leukres@hunterlink.net.au
Scorgie
Fiona E
FE
Robertson
Richard
R
Enno
Arno
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001554:Benzene / Q000378:metabolism; D016022:Case-Control Studies; D004851:Epoxide Hydrolases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000201:enzymology / Q000235:genetics*; D009247:NADH, NADPH Oxidoreductases / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D009247:NADH, NADPH Oxidoreductases; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases; D001554:Benzene