Alzheimer's disease presenting as corticobasal syndrome.
A 60-year-old man presented with slowly progressive left hemi-Parkinsonism, left hand apraxia, myoclonus, dystonia, visuospatial disturbances, and alien limb phenomenon, resembling corticobasal syndrome. Eight years later, neuropathology revealed features of Alzheimer's disease, with asymmetrical (right more than left) cortical tau burden with image analysis. The videotaped clinical features, neuropsychological aspects, and neuropathological correlates are presented and discussed.
Chand
Pratap
P
Department of Neurology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
Grafman
Jordan
J
Dickson
Dennis
D
Ishizawa
Keisuke
K
Litvan
Irene
I
D000544:Alzheimer Disease / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D001480:Basal Ganglia Diseases / Q000209:etiology* / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology; D007839:Functional Laterality; D006225:Hand / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000209:etiology; D019636:Neurodegenerative Diseases / Q000209:etiology* / Q000378:metabolism; D009483:Neuropsychological Tests; D058225:Plaque, Amyloid / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000209:etiology; D016875:tau Proteins / Q000378:metabolism
D016875:tau Proteins