title: Replication termination: mechanism of polar arrest revealed.
abstract: The Tus-Ter protein-DNA complex of Escherichia coli blocks progression of DNA replication from only one direction at the replication terminus. As the replication fork helicase unwinds one side of Ter, a conserved cytosine flips out of the duplex and binds to Tus, thereby creating a locked complex that blocks the advancing helicase.
authors.affiliation: Vanderbilt University, Department of Biological Sciences, VU Station B, Box 35-1634, Nashville, Tennessee 37235, USA. Daniel.Kaplan@Vanderbilt.Edu
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Kaplan
mesh_terms: D004265:DNA Helicases / Q000378:metabolism; D004261:DNA Replication / Q000502:physiology*; D004269:DNA, Bacterial / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000502:physiology*; D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000502:physiology*
chemical_list: C062011:DNA replication terminus site-binding protein, E coli; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D004265:DNA Helicases