Synthesis of functionalized quinolines via Ugi and Pd-catalyzed intramolecular arylation reactions.
Two types of quinoline scaffolds were constructed in a combinatorial format via the Ugi four-component reaction (U-4CR) and Pd-catalyzed intramolecular arylation reaction. The scope of this two-step synthetic sequence was examined from commercially available and synthetically accessible starting materials.
Ma
Zhibo
Z
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, China 100871.
Xiang
Zheng
Z
Luo
Tuoping
T
Lu
Kui
K
Xu
Zhibin
Z
Chen
Jiahua
J
Yang
Zhen
Z
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*
D006571:Heterocyclic Compounds; D011804:Quinolines; D010165:Palladium