Disseminated intravascular coagulation complicating resection of a malignant meningioma.
A 70-year-old woman developed disseminated intravascular coagulation (DIC) during a craniotomy for a parasagittal anaplastic/malignant meningioma. This was successfully treated with rapid resection of the tumour and haematological replacement, but a poor neurological outcome resulted. The tumour was demonstrated to express tissue factor, an important causative factor in other tumour associated DIC and previously shown to be expressed by malignant meningiomas. A link between the two is suggested.
Brecknell
J E
JE
Department of Neurosurgery, Alfred Hospital, Prahran, Australia. johnbrecknell@hotmail.com
McLean
C A
CA
Hirano
H
H
Malham
G M
GM
D000368:Aged; D001932:Brain Neoplasms / Q000378:metabolism / Q000601:surgery*; D003399:Craniotomy; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000209:etiology*; D008579:Meningioma / Q000378:metabolism / Q000601:surgery*; D009363:Neoplasm Proteins / Q000378:metabolism*; D013925:Thromboplastin / Q000378:metabolism*
D009363:Neoplasm Proteins; D013925:Thromboplastin