title: Rapid microwave-assisted fluorination yielding novel 5'-deoxy-5'-fluorouridine derivatives.
abstract: The preparation of (18)F-labeled ligands for positron emission tomography (PET) and the subsequent imaging have to be completed within a half-life of the neutron-deficient isotope ((18)F=110 min). In this paper, we report a rapid fluorination approach to obtain 5'-deoxy-5'-fluoro-substituted uracil nucleoside analogues. Nucleophilic substitution at the 5'-position of the nucleosides was achieved within 45 min providing excellent yields of 75-92% by application of microwaves.
authors.affiliation: Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Chemistry, Institute of Pharmacy, University of Bonn, Kreuzbergweg 26, 53115 Bonn, Germany. H.Le@uea.ac.uk <H.Le@uea.ac.uk>
authors.forename: H Phuoc
authors.initials: HP
authors.lastname: Le
authors.forename: Christa E
authors.initials: CE
authors.lastname: Müller
mesh_terms: D005467:Floxuridine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005461:Fluorine / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D013997:Time Factors
chemical_list: D005467:Floxuridine; D005461:Fluorine; C025034:doxifluridine