title: Factors affecting patency of subintimal infrainguinal angioplasty in patients with critical lower limb ischemia.
abstract: BACKGROUND
  Because subintimal angioplasty (SA) is a technique that can achieve recanalization of long arterial occlusions, it is considered an alternative to lower limb bypass operations. The aim of this prospective study was to identify the risk factors that affect patency of SA in patients suffering from critical limb ischemia (CLI).
  
  
  RESULTS
  51 consecutive infrainguinal SA were done in 46 patients suffered from CLI. The patients were followed-up with regular duplex scans up to 12 months post-intervention. Sex, atherosclerosis risk factors, and some technical details of the procedure (number of patent run-off vessels after the procedure, length and re-entry point of angioplasty) were examined as potential risk factors of patency, using survival analysis statistical techniques. The overall patency rate at 12 months post-intervention was 50%. According to Cox-regression analysis, the factors that affect patency were the number of run-off vessels and the length of occlusion. Patients with two or three run-off vessels had a hazard of occlusion of 0.30 (P = .027) compared to those who had one run-off vessel. The 12-months patency in patients with more than one run-off vessels was 81% vs. 25% in patients with one run-off vessel. Regarding the length of angioplasty, the hazard of reocclusion was 1.02 for every centimeter of occlusion (P = .049).
  
  
  CONCLUSIONS
  The number of patent run-off crural vessels after the angioplasty and the length of occlusion are significant risk factors for reocclusion of infrainguinal SA in patients with CLI. Trying to recanalize more than one run-off vessels could raise the SA patency.
authors.affiliation: Attikon Teaching Hospital, 3rd Surgical Department, Athens, Greece. amlazaris@med.uoa.gr
authors.forename: A M
authors.initials: AM
authors.lastname: Lazaris
authors.forename: C
authors.initials: C
authors.lastname: Salas
authors.forename: A C
authors.initials: AC
authors.lastname: Tsiamis
authors.forename: P A
authors.initials: PA
authors.lastname: Vlachou
authors.forename: A
authors.initials: A
authors.lastname: Bolia
authors.forename: G
authors.initials: G
authors.lastname: Fishwick
authors.forename: P R
authors.initials: PR
authors.lastname: Bell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D017130:Angioplasty / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000401:mortality / Q000601:surgery*; D053208:Kaplan-Meier Estimate; D023821:Limb Salvage; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000601:surgery; D011446:Prospective Studies; D012044:Regression Analysis; D012086:Reoperation; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D017539:Tunica Intima / Q000601:surgery; D014654:Vascular Patency