title: [High-frequency oscillatory ventilation. A single-center study].
abstract: BACKGROUND
  High-frequency oscillatory ventilation is a safe and effective means of delivering mechanical ventilatory support.
  
  
  OBJECTIVE
  To evaluate the safety and effectiveness of high-frequency oscillatory ventilation in pediatric patients with acute respiratory failure.
  
  
  METHODS
  From August 2003 to July 2005, we performed a prospective observational study of 11 children older than 1 month who underwent high-frequency oscillatory ventilation. Pediatric risk of mortality scores (PRISM), Murray lung-injury scores and air leak scores were recorded at baseline before ventilation. The following variables were studied: ventilatory settings (FiO2 and mean airway pressure), gasometric (PaO2, SaO2, PaCO2, pHa, PaO2/FiO2 ratio) and hemodynamic parameters (Partm, PVC), and the oxygenation index.
  
  
  RESULTS
  The overall survival rate was 82 %. Significant increases were found in PaO2 (p < 0.05), SaO2 (p < 0.05) and the PaO2/FiO2 ratio (p < 0.05), while mean airway pressure (p < 0.001), oxygenation index (p < 0.001), and FiO2 (p < 0.001) significantly decreased over time.
  
  
  CONCLUSIONS
  High-frequency oscillatory ventilation significantly improved oxygenation in children with acute hypoxemic respiratory failure.
authors.affiliation: Unidad de Gestión Clínica de Cuidados Críticos y Urgencias, Hospital Infantil Universitario Virgen del Rocío, Sevilla, España. garcier@wanadoo.es
authors.forename: J A
authors.initials: JA
authors.lastname: García Hernández
authors.forename: A
authors.initials: A
authors.lastname: Vázquez Florido
authors.forename: A I
authors.initials: AI
authors.lastname: Martínez López
authors.forename: J D
authors.initials: JD
authors.lastname: González Rodríguez
authors.forename: V M
authors.initials: VM
authors.lastname: Navas López
authors.forename: A
authors.initials: A
authors.lastname: Romero Parreño
authors.forename: A
authors.initials: A
authors.lastname: Cayuela Domínguez
authors.forename: M
authors.initials: M
authors.lastname: Loscertales Abril
mesh_terms: D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D006612:High-Frequency Ventilation; D006801:Humans; D007223:Infant; D011446:Prospective Studies; D012131:Respiratory Insufficiency / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome