title: Memory guided saccades in mesial temporal lobe epilepsy with hippocampal sclerosis.
abstract: OBJECTIVE
  Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) may involve extrahippocampal areas of structural and functional damage. The incidence and the features of this damage are still a matter of debate and vary depending on the method applied. Memory guided saccades (MGSs) with a memorization delay longer than 20s can be used reliably to evaluate the parahippocampal cortex.
  
  
  METHODS
  MGSs with 3 and 30s memorization delays were recorded with the search coil technique in six patients affected by right MTLE-HS, and in 13 healthy controls.
  
  
  RESULTS
  The patients were not able to reduce the MGSs residual amplitude error after the first saccade with a 30s memorization delay. This finding was more evident with leftward saccades.
  
  
  CONCLUSIONS
  MGS abnormalities suggested the functional involvement of the right parahippocampal cortex in most of the patients with MTLE-HS, and this supports the clinical and anatomopathological heterogeneity of the disease.
  
  
  CONCLUSIONS
  MGSs can be used in patients with right MTLE-HS to detect a possible functional involvement of the ipsilateral parahippocampal cortex.
authors.affiliation: Laboratorio Movimenti Oculari, Fondazione Istituto Neurologico C. Mondino IRCCS, Dipartimento di Scienze Neurologiche, Università degli Studi di Pavia, Italy. si.co@libero.it
authors.forename: S
authors.initials: S
authors.lastname: Colnaghi
authors.forename: C
authors.initials: C
authors.lastname: Arbasino
authors.forename: G
authors.initials: G
authors.lastname: Beltrami
authors.forename: C A
authors.initials: CA
authors.lastname: Galimberti
authors.forename: V
authors.initials: V
authors.lastname: Cosi
authors.forename: M
authors.initials: M
authors.lastname: Versino
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000503:physiopathology*; D005133:Eye Movements / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D012438:Saccades / Q000502:physiology*; D012598:Sclerosis
chemical_list: D000927:Anticonvulsants