title: A proteomics approach to identify protein expression changes in rat liver following administration of 3,5,3'-triiodo-L-thyronine.
abstract: We analyzed whole cell protein content of rat liver following T3 administration. Fourteen differentially expressed proteins were unambiguously identified and were involved in substrates and lipid metabolism, energy metabolism, detoxification of cytotoxic products, calcium homeostasis, amino acid catabolism, and the urea cycle. This study represents the first systematic identification of T3-induced changes in liver protein expression profile and provides novel information at the molecular, cellular, and tissue level of T3 action.
authors.affiliation: Dipartimento di Scienze Biologiche ed Ambientali, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Silvestri
authors.forename: Maria
authors.initials: M
authors.lastname: Moreno
authors.forename: Luigi
authors.initials: L
authors.lastname: Schiavo
authors.forename: Pieter
authors.initials: P
authors.lastname: de Lange
authors.forename: Assunta
authors.initials: A
authors.lastname: Lombardi
authors.forename: Angela
authors.initials: A
authors.lastname: Chambery
authors.forename: Augusto
authors.initials: A
authors.lastname: Parente
authors.forename: Antonia
authors.initials: A
authors.lastname: Lanni
authors.forename: Fernando
authors.initials: F
authors.lastname: Goglia
mesh_terms: D000818:Animals; D017931:DNA Primers; D015180:Electrophoresis, Gel, Two-Dimensional; D005786:Gene Expression Regulation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011506:Proteins / Q000032:analysis*; D040901:Proteomics / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D017931:DNA Primers; D011506:Proteins; D014284:Triiodothyronine