Contributions of undernutrition and handling to huddling development of rats.
When newborn rats are separated from the mother, they consistently exhibit the huddling response to maintain body temperature and physical contact. Therefore, we investigated if preweaning handling/sensory stimulation may overcome the huddling deficiencies associated to neonatal undernourishment/maternal deprivation of Wistar rats maintained at constant temperature (30 degrees C). The data indicated that initial and final temperatures in the pile of undernourished (U) and undernourished stimulated (Us) pups was reduced compared to their controls (C and Cs, respectively). Huddling latency was prolonged at 5 days of age in the Us group and at 20 days of age in the U pups. On postpartum day 5, U and Us subjects were similar in battery and pile-huddling performance compared to their controls; thereafter, the frequency of battery type was low and pile type was high (in frequency) in all experimental treatments. The frequency of recycling from the pile in the Us pups in most of the ages was significantly reduced compared to U and C subjects, suggesting that early sensory stimulation possibly accelerates the maturation of thermoregulatory brain structures underlying the huddling response and causing increased physical contacts. The data provide evidence that both neonatal undernutrition/maternal deprivation and early sensory stimulation may modify the huddling response by reducing or increasing, respectively, brain mechanisms underlying huddling. The amount of physical contact the newborns receive from their littermates and the mother may be a fundamental source of sensory cues for neuronal maturation and brain functioning.
Soriano
Ofelia
O
Department of Developmental Neurobiology and Neurophysiology, Neurobiology Institute, Universidad Nacional Autónoma de México, PO Box 1-1141, Campus Juriquilla Querétaro, Qro., 76001, México.
Regalado
Mirelta
M
Torrero
Carmen
C
Salas
Manuel
M
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development* / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D005260:Female; D006234:Handling, Psychological; D008297:Male; D044342:Malnutrition / Q000503:physiopathology* / Q000523:psychology; D008426:Maternal Deprivation; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012919:Social Behavior; D012931:Social Environment