Karyotype complexity and VH gene status in B-cell chronic lymphocytic leukemia.
B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and V(H) gene sequencing in a prospective clinical evaluation. The V(H) mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for specific VH gene usage (V(3-21) and V(1-69)). Complex karyotypes were highly indicative of disease progression.
Méhes
Gábor
G
Kovács
Gábor
G
Kajtár
Béla
B
Lacza
Agnes
A
Várnai
Alinda
A
Losonczy
Hajna
H
Pajor
László
L
D002869:Chromosome Aberrations; D005787:Gene Frequency; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007621:Karyotyping / Q000379:methods; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology / Q000235:genetics*; D011446:Prospective Studies; D027041:Somatic Hypermutation, Immunoglobulin / Q000235:genetics
D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region