Aspergillus galactomannan enzyme-linked immunosorbent assay cross-reactivity caused by invasive Geotrichum capitatum.
We report three cases of invasive Geotrichum capitatum infection in patients with acute leukemia for which an enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence of aspergillosis. Supernatants obtained from suspensions of 17 G. capitatum strains gave positive reactions with the Aspergillus galactomannan ELISA. These clinical and laboratory data seem to suggest that G. capitatum produces a soluble antigen that is cross-reactive with Aspergillus galactomannan.
Giacchino
Mareva
M
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza of Rome, Via Benevento 6, 00161 Rome, Italy.
Chiapello
Nadia
N
Bezzio
Stefania
S
Fagioli
Franca
F
Saracco
Paola
P
Alfarano
Alda
A
Martini
Vincenza
V
Cimino
Giuseppe
G
Martino
Pietro
P
Girmenia
Corrado
C
D000946:Antigens, Fungal / Q000276:immunology*; D001230:Aspergillus / Q000276:immunology*; D002648:Child; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D005847:Geotrichosis / Q000276:immunology / Q000382:microbiology; D005848:Geotrichum / Q000276:immunology*; D006801:Humans; D008297:Male; D008351:Mannans / Q000276:immunology*; D008875:Middle Aged
D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose