Transcriptional response of Escherichia coli to TPEN.
DNA microarrays were used to probe the transcriptional response of Escherichia coli to N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN). Fifty-five transcripts were significantly up-regulated, including all of the genes that are regulated by Zur and many that are regulated by Fur. In the same TPEN-treated cells, 46 transcripts were significantly down-regulated.
Sigdel
Tara K
TK
Department of Chemistry and Biochemistry, 160 Hughes Hall, Miami University, Oxford, OH 45056, USA.
Easton
J Allen
JA
Crowder
Michael W
MW
D000222:Adaptation, Physiological; D015536:Down-Regulation; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D005029:Ethylenediamines / Q000494:pharmacology*; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D007502:Iron Chelating Agents / Q000494:pharmacology*; D020411:Oligonucleotide Array Sequence Analysis; D014158:Transcription, Genetic / Q000187:drug effects*; D015854:Up-Regulation
D005029:Ethylenediamines; D007502:Iron Chelating Agents; C044387:N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine