title: Internal capsule size in good-outcome and poor-outcome schizophrenia.
abstract: Converging lines of research suggest that white matter abnormalities may be central to the pathophysiology of schizophrenia. The purpose of this study was to examine regional white matter in the anterior limb of the internal capsules in patients with schizophrenia. The authors obtained high-resolution magnetic resonance imaging in 106 patients with schizophrenia and 42 age and sex-matched healthy comparison subjects. The area of the anterior limb of the internal capsule was measured at five proportionately spaced dorsal-to-ventral levels. Schizophrenia patients were divided into good-outcome and poor-outcome groups, based on longitudinal analysis of self-care deficits. Patients with poor-outcome had significantly smaller dorsal areas than healthy comparison subjects, but good-outcome patients did not differ from healthy comparison subjects. Larger relative volumes of the caudate, putamen, and thalamus tended to be associated with relatively larger volumes of the internal capsule in healthy comparison subjects and good-outcome patients, consistent with the known frontal-striatal-thalamic pathways. Larger ventricles were associated with smaller internal capsules, particularly in healthy comparison subjects. The findings suggest disruption of internal capsule fibers in poor-outcome patients with schizophrenia. These abnormalities may be independent of other structural changes in schizophrenia.
authors.affiliation: Taub Institute, P&S 16, Columbia University Medical Center, 630 West 168th St., New York, NY 10032, USA. amb2139@columbia.edu
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.forename: Monte S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: Zlatin
authors.initials: Z
authors.lastname: Ivanov
authors.forename: Joan C
authors.initials: JC
authors.lastname: Borod
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Foldi
authors.forename: Eunice
authors.initials: E
authors.lastname: Hahn
authors.forename: Serge A
authors.initials: SA
authors.lastname: Mitelman
authors.forename: Erin A
authors.initials: EA
authors.lastname: Hazlett
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Lincoln
authors.forename: Randall E
authors.initials: RE
authors.lastname: Newmark
authors.forename: Lina
authors.initials: L
authors.lastname: Shihabuddin
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents