Subplate neurons foster inhibition.
Previous work demonstrates an essential role of subplate neurons during ocular dominance (OD) column formation in the developing visual cortex. While inhibitory circuitry has also been shown to play an essential role in OD plasticity, the relationship between subplate neurons and the development of inhibitory circuits has been unclear. In this issue of Neuron, Kanold and Shatz provide evidence that maturation of inhibitory circuitry requires subplate neurons in the developing cortex.
Ohshiro
Tomokazu
T
Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA.
Weliky
Michael
M
D000818:Animals; D023882:Dominance, Ocular / Q000502:physiology; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D014793:Visual Cortex / Q000196:embryology* / Q000502:physiology