Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium.
The hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium (CCRV) was studied in this paper. Alloxan and adrenalin induced hyperglycemic mice were used in the study. The blood glucose and the HbA1c of the mice were analyzed, respectively. At the same time, the sugar tolerance of the normal mice was also determined. After the mice were administered (ig) with CCRV, the blood glucose and the HbA1c of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01), ascension of blood glucose induced by adrenalin was inhibited (p < 0.01) and the sugar tolerance of the normal mice was improved. Also, the body weight of the alloxan-induced hyperglycemic mice was increased gradually. In the fermented mushroom of C. comatus, vanadium at lower doses in combination with C. comatus, induced significant decreases of the blood glucose and HbA1c levels in hyperglycemic mice.
Han
Chunchao
C
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250014, PR China. biobook2@sohu.com
Yuan
Junhua
J
Wang
Yingzi
Y
Li
Lingjun
L
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003302:Coprinus / Q000737:chemistry*; D004837:Epinephrine; D005260:Female; D005285:Fermentation; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis / Q000187:drug effects; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D014639:Vanadium / Q000737:chemistry / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects
D000496:Alloxan; D001786:Blood Glucose; D004837:Epinephrine; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D014639:Vanadium