Hyperglycemia and outcome after myocardial infarction and cardiac surgery: so what?
Hyperglycemia is a frequent observation during acute illness such as myocardial infarction and after major surgery. The proportion of patients with hyperglycemia may be as high as 95% to 100% after cardiac surgery. This stress-induced hyperglycemia has a detrimental effect on outcome after myocardial infarction and cardiac surgery. Mortality may increase by a factor of 4, especially in non-diabetic patients. Control of hyperglycemia to normalize blood glucose is associated with a clear clinical benefit. This effect is most beneficial in nondiabetic patients with hyperglycemia. The exact target level of glycemia is still a matter of investigation, but normalization to values between 80 and 125 mg/dL is probably optimal.
Hiesmayr
Michael J
MJ
Department of Cardiac-Thoracic-Vascular Anaesthesia & Intensive Care Medicine, Medical University Vienna, Vienna, Austria. michael.hiesmayr@meduniwien.ac.at
D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D015897:Comorbidity; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D007328:Insulin / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy / Q000453:epidemiology*; D013903:Thoracic Surgery
D007328:Insulin