Is the expression of kinin B(1) receptor related to intrahepatic vascular response?
Bradykinin elicits an intrahepatic vascular response (IHVR) mediated by the constitutive B(2) receptor (B(2)R). The biological effects of kinins may also be mediated by the inducible B(1) receptor (B(1)R).


OBJECTIVE
To verify if the hepatic B(1)R expression modulates IHVR to kinins.


METHODS
We evaluated the ability of bradykinin and B(1)R agonists to elicit an IHVR in normal rats and in those submitted to acute or chronic inflammatory stimuli, fibrosis, cirrhosis, or hepatic regeneration.


RESULTS
Bradykinin-induced IHVR was similar in all groups. B(1)R agonists did not elicit in any of them either a hypertensive or a hypotensive response. B(1) receptor induction was observed in all experimental groups (Western blot), except for the acute inflammatory group.


CONCLUSIONS
B(1)R hepatic expression did not modulate IHVR to kinins.
Nagaoka
Marcia R
MR
Department of Biochemistry, Laboratory of Experimental Hepatology, Universidade Federal de São Paulo (UNIFESP) Rua Botucatu, 862 Edifício Jose Leal Prado, São Paulo, Brazil.
Gomiero
Luciana
L
Teixeira
Felipe O
FO
Agostino
Fernando G
FG
Pouza
José Eduardo P
JE
Mimary
Priscila
P
Borges
Durval R
DR
Kouyoumdjian
Maria
M
D000210:Acute-Phase Reaction / Q000378:metabolism; D000818:Animals; D015153:Blotting, Western; D008099:Liver / Q000098:blood supply*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D043783:Receptor, Bradykinin B1 / Q000378:metabolism*
D043783:Receptor, Bradykinin B1