Cotranslocational degradation: utilitarianism in the ER stress response.
Recently, a new layer of the unfolded protein response was discovered that supports the cotranslocational degradation of nascent chains stalled in endoplasmic reticulum translocons (Oyadomari et al., 2006).
Pearse
Bradley R
BR
Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
Hebert
Daniel N
DN
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000502:physiology*; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
D008565:Membrane Proteins; D011506:Proteins