title: CT analysis and histopathology of bone remodeling in patients with chronic rhinosinusitis.
abstract: OBJECTIVE
  To evaluate the findings of computed tomography (CT) and histopathology of the bulla ethmoidalis as objective markers of bone remodeling in chronic rhinosinusitis (CRS).
  
  
  METHODS
  Preoperative ostiomeatal unit (OMU) scans and histopathologic findings of the bulla ethmoidalis were performed on 23 patients (39 sides) undergoing endoscopic sinus surgery for CRS. Lund-Mackay scores and Hounsfield units (HU) of the bulla were checked in coronal CT scans. The pathologist graded the severities of the mucosal and bony changes in histopathology. Statistical analysis was performed using Mann-Whitney U test and Spearman correlation coefficient (r).
  
  
  RESULTS
  The HU values of the bulla were significantly increased with higher Lund-Mackay scores in OMU CT (r = 0.405, P = 0.01). The bony grades in histopathology were significantly increased with higher mucosal grades (r = 0.821, P = 0.0001). These findings in CT scans and histopathology were well correlated with each other (r > 0.3, P < 0.05).
  
  
  CONCLUSIONS
  HU may be a useful objective marker of bone remodeling in chronic rhinosinusitis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Haeng-dang-dong 17, Sungdong-gu, Seoul 133-792, Korea.
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Cho
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Min
authors.forename: Hong Xiu
authors.initials: HX
authors.lastname: Han
authors.forename: Seung Sam
authors.initials: SS
authors.lastname: Paik
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D004724:Endoscopy; D005004:Ethmoid Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D009297:Nasal Mucosa / Q000473:pathology; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010521:Periosteum / Q000473:pathology; D011446:Prospective Studies; D012189:Retrospective Studies; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed