Allergic contact dermatitis to chloroxylenol.
Chloroxylenol, also known as p-chloro-m-xylenol (PCMX), is a compound that has been used as a preservative in cosmetics and as an active agent in antimicrobial soaps. We present two patients with allergic contact dermatitis from PCMX, confirmed by positive (+++) patch-test reactions at 48 and 72 hours, identification of PCMX in a soap and in a hand cream used by the patients, and improvement following withdrawal of the incriminating products. The mechanism of action, structure, antimicrobial activity, and dangers of PCMX are reviewed.
Berthelot
Cindy
C
University of Texas Medical School Southwestern, Dallas, TX, USA.
Zirwas
Matthew J
MJ
D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D004202:Disinfectants / Q000009:adverse effects*; D006229:Hand Dermatoses / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D006235:Hand Disinfection; D006801:Humans; D008297:Male; D010328:Patch Tests; D014992:Xylenes / Q000009:adverse effects*
D004202:Disinfectants; D014992:Xylenes; C007027:chloroxylenol