title: Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors.
abstract: A 192-member library of N,N'-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ionizable groups close to the urea group dramatically decreased their activities.
authors.affiliation: Department of Entomology and UCD Cancer Center, University of California, One Shields Avenue, Davis, CA 95616-8584, USA.
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Hwang
authors.forename: Christophe
authors.initials: C
authors.lastname: Morisseau
authors.forename: Zung
authors.initials: Z
authors.lastname: Do
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Hammock
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors*; D020128:Inhibitory Concentration 50; D007700:Kinetics; D012995:Solubility; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D014508:Urea; D004851:Epoxide Hydrolases