title: Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine.
abstract: The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45 degrees ), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.
authors.affiliation: Department of Neurology, University of Lübeck, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Sprenger
authors.forename: H
authors.initials: H
authors.lastname: Rambold
authors.forename: T
authors.initials: T
authors.lastname: Sander
authors.forename: S
authors.initials: S
authors.lastname: Marti
authors.forename: K
authors.initials: K
authors.lastname: Weber
authors.forename: D
authors.initials: D
authors.lastname: Straumann
authors.forename: C
authors.initials: C
authors.lastname: Helmchen
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077770:Amifampridine; D002524:Cerebellar Ataxia / Q000188:drug therapy* / Q000503:physiopathology; D004585:Electrooculography / Q000379:methods; D005133:Eye Movements / Q000187:drug effects; D005260:Female; D006112:Gravitation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009760:Nystagmus, Physiologic / Q000187:drug effects*; D026902:Potassium Channel Blockers / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D026902:Potassium Channel Blockers; D015761:4-Aminopyridine; D000077770:Amifampridine