[Inhibitors of mitochondrial permeability transition pore prevent apoptosis of dopaminergic neurons in the mesencephalon].
In the study the role of apoptosis in development of dopaminergic neuronal cell death within substantia nigra (parts compacta) and ventral tegmental area induced by 6-OHDA was investigated. It was found that intermittent hypoxia and the water-soluble vitamine E (Trolox) and melatonin, as antioxidants and inhibitors of mitochondrial permeability transition pore protect dopaminergic cells from cytotoxic effect of 6-OHDA. It is supposed that mitochondrial permeability transition pore plays an important role in apoptosis of neurons in the brain.
Talanov
S O
SO
Sahach
V F
VF
Oleshko
M M
MM
Maĭs'kyĭ
V O
VO
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002839:Chromans / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D033681:Mitochondrial Membrane Transport Proteins / Q000037:antagonists & inhibitors*; D000083162:Mitochondrial Permeability Transition Pore; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D011921:Rats, Inbred WKY; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
D002839:Chromans; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D016627:Oxidopamine; D008550:Melatonin; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; D004298:Dopamine