Adenovirus fulminant hepatic failure: disseminated adenovirus disease after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia.
Adenovirus is one of the major causes of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation for hematological malignancy. Fulminant hepatic failure is a rare manifestation of post-transplant complication with adenovirus. Extremely high mortality and aggressiveness of the clinical course have been posing clinical challenges for the diagnosis as well as for the treatment. Here, we report a case with disseminated adenovirus disease presenting with fulminant hepatic failure after bone marrow transplantation for acute lymphoblastic leukemia.
Nakazawa
Hideyuki
H
Department of Internal Medicine/Hematology, Shinshu University School of Medicine, Matsumoto, Nagano.
Ito
Toshiro
T
Makishima
Hideki
H
Misawa
Noriko
N
Okiyama
Wataru
W
Uehara
Takeshi
T
Hidaka
Eiko
E
Kiyosawa
Kendo
K
Ishida
Fumihiro
F
D000257:Adenoviridae Infections / Q000150:complications* / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000473:pathology; D017114:Liver Failure, Acute / Q000473:pathology / Q000821:virology*; D008854:Microscopy, Electron; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous