DC-SIGN and immunoregulation.
Dendritic cells (DCs) are known to be the most powerful professional antigen-presenting cells so far. It could activate primary immune response, and also downregulate immune response. DCs have a unique character of immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the C-type lectin superfamily. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. DC-SIGN has become hotspot of recent studies because of its important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. These studies on DC-SIGN involved in primary and secondary immune response and relevant mechanism will certainly provide us with a new method in treating and preventing certain diseases.
Zhou
Tong
T
Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200025, China. zhoutong_cn@hotmail.com
Chen
Yongxi
Y
Hao
Li
L
Zhang
Yanyun
Y
D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000502:physiology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007109:Immunity; D037181:Lectins, C-Type / Q000737:chemistry / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology*; D051192:Receptors, Pattern Recognition / Q000276:immunology; D019139:Tumor Escape / Q000276:immunology; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D051192:Receptors, Pattern Recognition; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin