Motor learning in children with spina bifida: intact learning and performance on a ballistic task.
Learning and performance on a ballistic task were investigated in children with spina bifida meningomyelocele (SBM), with either upper level spinal lesions (n = 21) or lower level spinal lesions (n = 81), and in typically developing controls (n = 35). Participants completed three phases (20 trials each) of an elbow goniometer task that required a ballistic arm movement to move a cursor to one of two target positions on a screen, including (1) an initial learning phase, (2) an adaptation phase with a gain change such that recalibration of the ballistic arm movement was required, and (3) a learning reactivation phase under the original gain condition. Initial error rate, asymptotic error rate, and learning rate did not differ significantly between the SBM and control groups. Relative to controls, the SBM group had reduced volumes in the cerebellar hemispheres and pericallosal gray matter (the region including the basal ganglia), although only the pericallosal gray matter was significantly correlated with motor adaptation. Congenital cerebellar dysmorphology is associated with preserved motor skill learning on voluntary, nonreflexive tasks in children with SBM, in whom the relative roles of the cerebellum and basal ganglia may differ from those in the adult brain.
Dennis
Maureen
M
Brain and Behaviour Program, Department of Psychology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada. maureen.dennis@sickkids.ca
Jewell
Derryn
D
Edelstein
Kim
K
Brandt
Michael E
ME
Hetherington
Ross
R
Blaser
Susan E
SE
Fletcher
Jack M
JM
D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D002648:Child; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology; D004550:Elbow / Q000294:innervation / Q000503:physiopathology; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009068:Movement / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D016135:Spinal Dysraphism / Q000503:physiopathology*