title: [A case report: small cell carcinoma transformed from transitional cell carcinoma of the urinary bladder].
abstract: A 72-year-old man presented with gross hematuria. Cystoscopy showed a non-papillary tumor at the right side of the posterior wall. Transurethral resection of the bladder tumor (TURBT) was performed. Pathologic findings demonstrated superficial transitional cell carcinoma (TCC). However, recurrent tumors were detected at the same location after 69 months' follow up. TURBT was done for the biopsy and pathologic examination showed muscle-invasive TCC. After two courses of neoadjuvant chemotherapy (MVAC), we performed radical cystectomy with Hautmann's continent reservoir. Pathologic findings revealed small cell carcinoma without any TCC features. Immunohistochemical staining using chromogranin A and synaptophysin was positive in the latest TURBT and the radical cystectomy specimens. We report a case of primary small cell carcinoma transformed from TCC of the urinary bladder.
authors.affiliation: The Department of Urology, Kitasato University School of Medicine.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hirayama
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Sinji
authors.initials: S
authors.lastname: Kurosaka
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Muramoto
authors.forename: Akira
authors.initials: A
authors.lastname: Irie
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Iwamura
authors.forename: Shiro
authors.initials: S
authors.lastname: Baba
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Uchida
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ichinohe
authors.forename: Keiichi
authors.initials: K
authors.lastname: Iwabuchi
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D001749:Urinary Bladder Neoplasms / Q000473:pathology*