title: Lack of effect of donor-recipient ABO mismatching on outcome following allogeneic hematopoietic stem cell transplantation.
abstract: Several recently published studies have suggested that patients who undergo ABO mismatched hematopoietic stem cell transplantation may be at increased risk for relapse, graft-versus-host disease, transplant-related mortality, and/or all-cause mortality. To investigate this issue further, we analyzed potential associations between the donor-recipient ABO mismatch pattern and the above outcome measures among 240 consecutive patients who underwent allogeneic hematopoietic stem cell transplantation at our institution. Our analyses uncovered no significant associations between donor-recipient ABO mismatch pattern and overall survival, event-free survival, transplant-related mortality, incidence of acute graft-versus-host disease (GVHD), or incidence of chronic GVHD. Our data do not support recent assertions that donor-recipient ABO mismatching is a major risk factor for patients undergoing allogeneic transplant, nor do they support recent assertions that ABO matching should be an important consideration in selecting allogeneic hematopoietic stem cell donors.
authors.affiliation: Fox Chase-Temple University Bone Marrow Transplant Program, Temple University School of Medicine, Philadelphia, PA 19111-2442, USA. klumpptr@tuhs.temple.edu
authors.forename: T R
authors.initials: TR
authors.lastname: Klumpp
authors.forename: J H
authors.initials: JH
authors.lastname: Herman
authors.forename: J
authors.initials: J
authors.lastname: Ulicny
authors.forename: R V B
authors.initials: RV
authors.lastname: Emmons
authors.forename: M E
authors.initials: ME
authors.lastname: Martin
authors.forename: K F
authors.initials: KF
authors.lastname: Mangan
mesh_terms: D000017:ABO Blood-Group System; D001788:Blood Grouping and Crossmatching / Q000379:methods; D018572:Disease-Free Survival; D046148:Donor Selection / Q000379:methods; D005260:Female; D006086:Graft vs Host Disease / Q000401:mortality; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000401:mortality* / Q000628:therapy; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D000017:ABO Blood-Group System