title: Quantification of distension in rat cerebral perforating arteries.
abstract: We developed a novel cerebral angiography procedure for rodents using monochromatic synchrotron radiation X-rays and obtained images of rat cerebral perforating arteries for the first time. In normotensive rat, hypercapnia rapidly distended the perforators between 3 and 15 min after induction and major trunk vessels distended more rapidly in 3-6 min. Systemic hypotension made by stepwise hemorrhage distended the perforators up to 158% of control values but constricted most of the large cerebral trunk vessels. In spontaneous hypertensive rats, systemic hypotension-induced distension disappeared in perforators, indicating that perforators with chronic hypertension lose their autoregulatory distensibility.
authors.affiliation: Department of Neurosurgery, Graduate School of Medicine, Kobe University, Kobe, Japan.
authors.forename: Akitsugu
authors.initials: A
authors.lastname: Morishita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakurai
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ikeda
authors.forename: Abesh Kumar
authors.initials: AK
authors.lastname: Bhattacharjee
authors.forename: Seiji
authors.initials: S
authors.lastname: Nakajima
authors.forename: Eiji
authors.initials: E
authors.lastname: Kohmura
authors.forename: Koichi
authors.initials: K
authors.lastname: Yokono
authors.forename: Keiji
authors.initials: K
authors.lastname: Umetani
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002533:Cerebral Angiography / Q000379:methods; D002536:Cerebral Arteries / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D020299:Intracranial Hemorrhage, Hypertensive / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014057:Tomography, X-Ray Computed / Q000379:methods