title: Part 2: building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. Modular solution- and solid-phase approaches for use in high-throughput generation of chemical probes.
abstract: The solution- and solid-phase synthesis to obtain several natural-product-like, tetrahydroquinoline-based, polycyclic derivatives were developed. In one approach, two derivatives (38 and 41) having an eight-membered unsaturated lactam were successfully obtained both in solution and on solid support.
authors.affiliation: Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada, K1A 0R6.
authors.forename: Utpal
authors.initials: U
authors.lastname: Sharma
authors.forename: Stuti
authors.initials: S
authors.lastname: Srivastava
authors.forename: Michael
authors.initials: M
authors.lastname: Prakesch
authors.forename: Maya
authors.initials: M
authors.lastname: Sharma
authors.forename: Donald M
authors.initials: DM
authors.lastname: Leek
authors.forename: Prabhat
authors.initials: P
authors.lastname: Arya
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D000634:Aminoquinolines / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000634:Aminoquinolines; D015335:Molecular Probes; D011083:Polycyclic Compounds; D012996:Solutions