Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage.
OBJECTIVE
To determine whether the cytochrome P450 1B1 (CYP1B1) Val432Leu polymorphism is associated with risk of miscarriage. We also analyzed the possible interaction between this polymorphism and caffeine intake.


METHODS
The population-based case-control study included 507 women with miscarriage in the first trimester of pregnancy and 908 controls with a normal first-trimester pregnancy. The controls were frequency matched to cases. The material was analyzed taking maternal age, smoking habits, alcohol intake, caffeine intake, fetal karyotype, nausea, and vomiting into consideration.


METHODS
University hospital and primary care facility.


METHODS
CYP1B1 Val432Leu genotype frequencies in cases and controls.


RESULTS
Carriers of the CYP1B1 432 Val/Val genotype were at a higher risk of miscarriage in the first trimester of pregnancy (odds ratio = 1.46; 95% confidence interval, 1.02-2.08). We also found a significant interaction between genotype and caffeine intake.


CONCLUSIONS
CYP1B1 Val432Leu polymorphism is associated with first-trimester miscarriage, and it may also modify the risk among coffee drinkers.
Karypidis
Anna-Helena
AH
Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital (Huddinge), Stockholm, Sweden. helena.karypidis@ki.se
Söderström
Torbjörn
T
Nordmark
Anna
A
Granath
Fredrik
F
Cnattingius
Sven
S
Rane
Anders
A
D000022:Abortion, Spontaneous / Q000453:epidemiology* / Q000235:genetics*; D001189:Aryl Hydrocarbon Hydroxylases; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000235:genetics*; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology
D005819:Genetic Markers; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1