Distachyasin: A new antioxidant metabolite from the leaves of Carex distachya.
A novel antioxidant prenylated stilbenoid, distachyasin, has been isolated from the leaves of Carex distachya. Its structure has been elucidated on the basis of the spectroscopic characteristics. Bidimensional NMR, and crystallographic data and computational calculations have furnished important data useful for the characterization and the stereochemistry of the molecule. The compound has a tetracyclic skeleton derived from carexane. The compound has been assayed, for the antioxidant activity, by measuring its capacity to scavenge the H(2)O(2), nitric oxide, superoxide radical and to inhibit formation of TBARS (thiobarbituric acid reactive species).
Fiorentino
Antonio
A
Dipartimento di Scienze della Vita, Seconda Università degli studi di Napoli, via Vivaldi 43, 81100 Caserta, Italy. antonio.fiorentino@unina2.it <antonio.fiorentino@unina2.it>
D'Abrosca
Brigida
B
Pacifico
Severina
S
Iacovino
Rosa
R
Mastellone
Claudio
C
Di Blasio
Benedetto
B
Monaco
Pietro
P
D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism*; D031255:Carex Plant / Q000737:chemistry* / Q000378:metabolism*; D005609:Free Radicals / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009573:Nitrites / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000378:metabolism*; D013267:Stilbenes / Q000737:chemistry* / Q000378:metabolism*; D013481:Superoxides / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances / Q000737:chemistry; D014961:X-Ray Diffraction
D000975:Antioxidants; D005609:Free Radicals; D009573:Nitrites; D011083:Polycyclic Compounds; D013267:Stilbenes; D017392:Thiobarbituric Acid Reactive Substances; C515888:distachyasin; D013481:Superoxides; D006861:Hydrogen Peroxide