Brønsted acid catalyzed addition of phenols, carboxylic acids, and tosylamides to simple olefins.
Intermolecular addition of phenols, carboxylic acids, and protected amines to inert olefins can be catalyzed by low concentrations (1-5%) of triflic acid. Functional groups, such as the methoxyl substitution on aromatics, could be tolerated if the concentration of triflic acid and the reaction temperature are controlled appropriately. This reaction provides one of the simplest olefin addition methods and is an alternative to metal-catalyzed reactions.
Li
Zigang
Z
Department of Chemistry, University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
Zhang
Junliang
J
Brouwer
Chad
C
Yang
Cai-Guang
CG
Reich
Nicholas W
NW
He
Chuan
C