Childhood hemolytic uremic syndrome is associated with adolescent-onset diabetes mellitus.
Extra-renal manifestations of the hemolytic uremic syndrome in children are well described. Pancreatic involvement may manifest as transient hyperglycemia and permanent diabetes mellitus. Two previous case reports demonstrate short periods of "remission" between initial hyperglycemia and the development of permanent diabetes mellitus. We report an unusual case of a two-year-old Caucasian boy whose HUS-associated hyperglycemia resolved shortly after the acute phase of his illness only to recur as permanent diabetes mellitus at puberty. To our knowledge no other case is reported that demonstrates such a long interval between initial presentation and the development of permanent diabetes mellitus.
Nesmith
J Darrell
JD
Department of Pediatrics, University of Arkansas for Medical Sciences, 800 Marshall St, Little Rock, AR 72202, USA. nesmithjamesd@uams.edu
Ellis
Eileen
E
D000293:Adolescent; D017668:Age of Onset; D002675:Child, Preschool; D048909:Diabetes Complications / Q000150:complications; D003920:Diabetes Mellitus / Q000209:etiology* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000209:etiology*; D006463:Hemolytic-Uremic Syndrome / Q000150:complications*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000209:etiology; D008297:Male; D013997:Time Factors