Examining the relationship between obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in children and adolescents: a familial risk analysis.
BACKGROUND
To use family study methodology to examine the relationship between obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in children and adolescents.


METHODS
We assessed for ADHD and OCD in the 1533 first-degree relatives of three groups of index children: those with ADHD and OCD, those with ADHD but no OCD, and matched controls with neither disorder.


RESULTS
The risk for ADHD was similarly elevated in families of ADHD youth with (18.9%) and without OCD (20.1%; p = .91), and both groups had significantly higher rates of ADHD compared with controls (4.6%; p < or = .001), which was consistent with previous research showing a strong familial risk for ADHD. The risk for OCD was significantly elevated only among relatives of youth with ADHD plus comorbid OCD (13.0%) compared with controls (.5%; p < or = .001) and was consistent with previous research showing a strong familial risk for OCD. Relatives affected with ADHD had a significantly elevated risk for OCD compared with relatives unaffected by ADHD (7.4% vs. 1.3%; p < .001), suggestive of co-segregation between these disorders. There was no evidence of nonrandom mating between ADHD- and OCD-affected spouses.


CONCLUSIONS
These results extend previously reported findings regarding the heritability of both ADHD and OCD and provide new evidence of a familial relationship between ADHD and pediatric OCD that best fits the hypothesis of a unique familial subtype.
Geller
Daniel
D
Pediatric Psychopharmacology Program, Center for Human Genetics, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02113, USA. dageller@partners.org
Petty
Carter
C
Vivas
Fe
F
Johnson
Jessica
J
Pauls
David
D
Biederman
Joseph
J
D000293:Adolescent; D017668:Age of Onset; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology* / Q000523:psychology; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D015588:Observer Variation; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D018570:Risk Assessment