title: Disorders of learning and memory processes in a monkey model of Alzheimer's disease: the role of the associative area of the cerebral cortex.
abstract: The processes of learning and storage of the results of learning were studied in a model of Alzheimer's disease in two groups of rhesus macaques (three individuals in each group). Studies were performed after injection of neurotoxins (group I) and physiological saline (group II, controls). Two months after injections (stage C1), learning parameters were studied in monkeys of both groups using a new stimulus discrimination test (filled geometrical figures versus outline figures). There were significant differences between the animals of the two groups. Learning was hindered in monkeys of group I, with significant increases in the learning time (the time to achieve a stable probability of correct responding of 0.85) and in the probability of refusals. Monkeys of group II showed no learning impairment. Animals were trained to discriminate new stimuli (images of two monkeys) six months after injections (stage C3). Learning was impaired in animals of group I, such that learning measures had the same levels as previously; monkeys of group II showed no learning impairment. Analysis of the characteristics of working memory, which is involved in storing the results of new learning, was performed at stage C1; monkeys of group I showed significant degradation of these measures, with a significant decrease in the probability of correct solutions at stage C1 (to a level of 0.5), with some increase at stages C2 (at four months) and C3, along with a significant increase in the probability of refusals, values being similar at all time points. For monkeys of group II, these characteristics showed no degradation. Motor response times at stages C1, C2, and C3 were not different for the two groups of monkeys. The structural-functional organization of interactions between sensory and cognitive processes during learning and the storage of information in working memory are discussed, as is the role of the associative areas of the cortex in these interactions.
authors.affiliation: Cognitive Processes Modeling Group and Neuromorphology Laboratory, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St. Petersburg, Russia.
authors.forename: K N
authors.initials: KN
authors.lastname: Dudkin
authors.forename: I V
authors.initials: IV
authors.lastname: Chueva
authors.forename: F N
authors.initials: FN
authors.lastname: Makarov
authors.forename: T G
authors.initials: TG
authors.lastname: Bich
authors.forename: A E
authors.initials: AE
authors.lastname: Roher
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D000818:Animals; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000503:physiopathology*; D004193:Discrimination Learning / Q000502:physiology; D004195:Disease Models, Animal; D007859:Learning Disabilities / Q000209:etiology*; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000502:physiology*; D009498:Neurotoxins; D010364:Pattern Recognition, Visual / Q000187:drug effects / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D011336:Probability; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology
chemical_list: D009498:Neurotoxins