title: Brief report: no evidence for parvovirus B19 or hepatitis E virus as a cause of acute liver failure.
abstract: Viral hepatitis A and B are known to cause acute liver failure. While nearly 20% of acute liver failure cases are of indeterminate etiology, screening for other viruses has not been uniformly performed. We looked for evidence for parvovirus B19 and hepatitis E virus in sera from U.S. acute liver failure patients. For B19, 78 patients' sera, including 34 with indeterminate etiology, were evaluated by DNA dot-blot hybridization, reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay for immunoglobin G and M antibodies; none showed evidence for infection.
authors.affiliation: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8887, USA. William.Lee@utsouthwestern.edu
authors.forename: W M
authors.initials: WM
authors.lastname: Lee
authors.forename: K E
authors.initials: KE
authors.lastname: Brown
authors.forename: N S
authors.initials: NS
authors.lastname: Young
authors.forename: G J
authors.initials: GJ
authors.lastname: Dawson
authors.forename: G G
authors.initials: GG
authors.lastname: Schlauder
authors.forename: R A
authors.initials: RA
authors.lastname: Gutierrez
authors.forename: R
authors.initials: R
authors.lastname: Fontana
authors.forename: L
authors.initials: L
authors.lastname: Rossaro
authors.forename: T
authors.initials: T
authors.lastname: Davern
authors.forename: E
authors.initials: E
authors.lastname: Lalani
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood*; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D017114:Liver Failure, Acute / Q000097:blood* / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology; D012367:RNA, Viral / Q000097:blood*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral