title: Catheter-directed thrombolysis of acute deep vein thrombosis in the lower extremity of a child with interrupted inferior vena cava.
abstract: We present the case of a 14-year-old girl who developed acute deep vein thrombosis (DVT) in her right lower extremity. Laboratory testing revealed protein S deficiency, and the patient's father also had this abnormality with a history of lower extremity DVT. Manual thromboaspiration followed by catheter-directed thrombolysis resulted in total clearance of all thrombi. Computed tomography and later venography revealed an interrupted inferior vena cava. Catheter-directed thrombolysis is an established treatment for adults with acute DVT. To the best of our knowledge, this report is the first to describe catheter-directed thrombolysis in a pediatric patient with lower extremity DVT. Our results suggest that catheter-directed thrombolysis is safe and effective for use in selected older children and adolescents with acute DVT in the lower extremity.
authors.affiliation: Department of Radiology, Baskent University, Adana Teaching and Medical Research Center, Adana, Turkey. loguzkurt@yahoo.com
authors.forename: Levent
authors.initials: L
authors.lastname: Oguzkurt
authors.forename: Ugur
authors.initials: U
authors.lastname: Ozkan
authors.forename: Fahri
authors.initials: F
authors.lastname: Tercan
authors.forename: Zafer
authors.initials: Z
authors.lastname: Koc
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002408:Catheters, Indwelling; D005260:Female; D005268:Femoral Vein / Q000473:pathology; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007084:Iliac Vein / Q000473:pathology; D035002:Lower Extremity / Q000098:blood supply*; D011152:Popliteal Vein / Q000473:pathology; D014682:Vena Cava, Inferior / Q000473:pathology; D020246:Venous Thrombosis / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents