[Antioxidant modification of ionizing irradiation and additional stress effects on higher nervous activity in rats].
The aim of this study was to investigate the oxidative effect of the low-level radiation upon the higher nervous activity. Behavioral (shuttle-box) and statistical methods were used. The effect of the ionizing radiation (0.05 Gy) upon the indices of rats behavioral reaction as well as ability of some antioxidants (alpha-tocopherol, ascorbic acid, beta-carotene) used separately and in complex to diminish exposure effects on the indices studied have been investigated Beta-carotene demonstrated the largest protective effect alone and as a component in complex compound. Alpha-tocopherol used in animal exposured to the dose of 0.05 Gy, could case decline of the rats behavior reactions indices; this suggest that use of antioxidant therapy demands certain cautiousness. The results obtained suggest dominant role of the oxidant stress during ionizing radiation at least in dose of 0.05 Gy.
Tukalenko
Ie V
IeV
Varets'kyĭ
V V
VV
Rakochi
O H
OH
Dmytriieva
I R
IR
Makarchuk
M Iu
MIu
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000528:radiation effects; D006613:Higher Nervous Activity / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D024502:alpha-Tocopherol / Q000494:pharmacology; D019207:beta Carotene / Q000494:pharmacology
D000975:Antioxidants; D019207:beta Carotene; D024502:alpha-Tocopherol; D001205:Ascorbic Acid