Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea.
Twenty-two algal species were evaluated for their potential anticoagulant activities. Hot water extracts from selected species, Codium fragile and Sargassum horneri showed high activated partial thromboplastin time (APTT). Ultraflo extract of C. fragile and S. horneri exhibited the most potent anticoagulant activity. Furthermore, in both algal species, active compounds were mainly concentrated in >30kDa faction. The crude polysaccharide fraction (>30kDa; CpoF) of C. fragile composed of approximately 80% carbohydrate and approximately 19% of protein; the crude polysaccharide fraction (>30kDa; CpoF) of S. horneri was composed of 97% of carbohydrate and approximately 2% of protein. Therefore, most probably the active compound, or compounds of the algal species were related to high molecular weight polysaccharide, or a complex form with carbohydrate and protein (proteoglycan).
Athukorala
Yasantha
Y
Faculty of Applied Marine Science, Cheju National University, Jeju 690-756, South Korea.
Lee
Ki-Wan
KW
Kim
Se-Kwon
SK
Jeon
You-Jin
YJ
D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D000460:Chlorophyta / Q000737:chemistry* / Q000235:genetics; D005843:Geography; D006801:Humans; D007723:Korea; D008970:Molecular Weight; D000459:Phaeophyceae / Q000737:chemistry* / Q000235:genetics; D011517:Prothrombin Time
D000925:Anticoagulants