title: Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark.
abstract: The hydroalcoholic extract of Maytenus krukovii bark was investigated for its in vitro mutageno-protective activities by means of the Ames Salmonella/microsome assay. The extract showed an inhibitory effect in both T98 and T100 strains against the mutagenic activity of promutagen 2-aminoanthracene but was not protective against directly acting mutagens sodium azide and 2-nitrofluorene. When tested as a radical scavenger and antioxidant it produced a dose-dependent inhibition. The extract did not show significant antibacterial properties, and was weakly active against dermatophyte and phytopathogenic fungi, but inhibited the growth of phytopathogen Pithyum ultimum.
authors.affiliation: Dipartimento di Biologia Evolutiva e Funzionale, Parco Area delle Scienze 11, 43100 Parma, Italy. bruni@biol.unipr.it
authors.forename: Renato
authors.initials: R
authors.lastname: Bruni
authors.forename: Damiano
authors.initials: D
authors.lastname: Rossi
authors.forename: Mariavittoria
authors.initials: M
authors.lastname: Muzzoli
authors.forename: Carlo
authors.initials: C
authors.lastname: Romagnoli
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Paganetto
authors.forename: Elena
authors.initials: E
authors.lastname: Besco
authors.forename: Fritz
authors.initials: F
authors.lastname: Choquecillo
authors.forename: Katia
authors.initials: K
authors.lastname: Peralta
authors.forename: William Schmitt
authors.initials: WS
authors.lastname: Lora
authors.forename: Gianni
authors.initials: G
authors.lastname: Sacchetti
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001713:Biphenyl Compounds; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008297:Male; D029755:Maytenus; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D009152:Mutagenicity Tests; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012475:Salmonella / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D016587:Antimutagenic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl