[Molecular mechanism of tissue-specific actions of SERM].
Selective estrogen receptor modulator (SERM) is designated as synthetic ligands for estrogen receptors (ERs), exhibiting tissue-specific agonisitic/antagonisitic activities. Among SERM, raloxifen is a most clinically successful as an anti-oseteoporotic agent. Such tissue-specific actions of SERM are presumed to mediate through unusual structure alteration of liganded ERs coupled with co-regulator recruitments.
Kato
Shigeaki
S
The Institute of Molecular and Cellular Biosciences, The University of Tokyo/ERATO, JST.
D050071:Bone Density Conservation Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009928:Organ Specificity; D010024:Osteoporosis; D020849:Raloxifene Hydrochloride / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D011960:Receptors, Estrogen / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D014158:Transcription, Genetic
D050071:Bone Density Conservation Agents; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride