Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.
Several Toyocamycin (4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio (18) and 5-carboxamide oxime derivatives (23 and 27) of Toyocamycin were found to have good activity and selectivity.
Varaprasad
Chamakura V N S
CV
Drug Discovery, Valeant Pharmaceuticals Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. vchamakura@gmail.com
Ramasamy
Kanda S
KS
Girardet
Jean-Luc
JL
Gunic
Esmir
E
Lai
Vicky
V
Zhong
Weidong
W
An
Haoyun
H
Hong
Zhi
Z
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006526:Hepatitis C / Q000188:drug therapy / Q000378:metabolism / Q000821:virology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors / Q000378:metabolism; D014127:Toyocamycin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides; D011743:Pyrimidines; D011758:Pyrroles; C450639:Pyrrolo(2,3-d)pyrimidine; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase; D014127:Toyocamycin