title: Cardiovascular risk factors in pre-pubertal Malays: effects of diabetic parentage.
abstract: Diabetes prevalence is increasing rapidly in Asian populations but the influence of a family history of diabetes on cardiovascular risk is unknown. To assess this relationship, 120 urban-dwelling Malays were recruited to a cross-sectional case-control study. Sixty were pre-pubertal children, 30 of diabetic parentage (Group 1) and 30 with no diabetes family history (Group 2). Group 1 and 2 subjects were the offspring of adults with (Group 3) or without (Group 4) type 2 diabetes. Subjects were assessed for clinical and biochemical variables defining cardiovascular risk. Principal component analysis assessed clustering of variables in the children. Group 1 subjects had a higher mean waist:hip ratio, diastolic blood pressure and HbA(1c) than those in Group 2, and a lower HDL:total cholesterol ratio (P<0.03). Although there were no correlations between Group 1 and 3 subjects for cardiovascular risk variables, significant associations were found in Groups 2 and 4, especially HbA(1c) and insulin sensitivity (P< or =0.004). Of five separate clusters of variables (factors) identified amongst the children, the strongest comprised diabetic parentage, HbA(1c), insulin sensitivity and blood pressure. Features of the metabolic syndrome are becoming evident in the young non-obese children of diabetic Malays, suggesting that lifestyle factors merit particular attention in this group.
authors.affiliation: Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Malaysia.
authors.forename: Keng Ee
authors.initials: KE
authors.lastname: Choo
authors.forename: Kim Bee
authors.initials: KB
authors.lastname: Lau
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Davis
authors.forename: Peng Hong
authors.initials: PH
authors.lastname: Chew
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Jenkins
authors.forename: Timothy M E
authors.initials: TM
authors.lastname: Davis
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000378:metabolism; D005190:Family; D005215:Fasting; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D008296:Malaysia / Q000453:epidemiology; D008875:Middle Aged; D010375:Pedigree; D025341:Principal Component Analysis / Q000379:methods; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014505:Urban Population / Q000706:statistics & numerical data; D014527:Uric Acid / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D003404:Creatinine; D006442:Glycated Hemoglobin; D007328:Insulin; D014280:Triglycerides; D014527:Uric Acid