[Effect of the activity of an indirect anticoagulant by a monoamine oxidase inhibitor].
The combinations of some anticoagulants (phenindione, chlorphenadione, diphenadione, phenprocoumon, 3-[1-(p-chlorophenyl)propyl]-4-hydroxycoumarin, cumachlor and acenocoumarol) with MAO-inhibitors (phenylcyclopropylamino hydrochloride, isocarboxazid, iproniazid, nialamide and p-chloro-N'-[2-(isopropylcarbamoyl)-1-methylethyl]benzohydrazide) were investigated with regard to modification of the anticoagulant activity in the rat. The activity of some anticoagulants like phenindione may be enhanced by the addition of MAO-inhibitors, whereas others (chlorphenadione, phenprocoumon) are only slightly or not at all influenced. The MAO-inhibitors phenylcyclopropylamino hydrochloride and nialamide show enhancement of activity in most combinations whereas iproniazid never does. The other MAO-inhibitors lie between these two extremes.
Reber
K
K
Abteilung für experimentelle Medizin der F. Hoffmann-La Roche & Co. AG., Basel.
Studer
A
A
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004357:Drug Synergism; D007700:Kinetics; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats
D000925:Anticoagulants; D008996:Monoamine Oxidase Inhibitors