Glucose-insulin-potassium techniques in cardiac surgery: historical overview and future perspectives.
Since the days of the first cardiac surgical operations in the previous century, myocardial preservation has been an essential component of the successful outcome of these procedures. Although many different techniques to achieve myocardial preservation and modulation have been described in the past 50 years, this review focuses on the use of glucose, insulin, and potassium (GIK) and its effect on ischemic and postischemic myocardium.
Van Wezel
Harry B
HB
Department of Anesthesiology, Academic Medical Center, Amsterdam, AZ Amsterdam, The Netherlands. H.B.vanwezel@amc.uva.nl
D002986:Clinical Trials as Topic; D005947:Glucose / Q000266:history / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007328:Insulin / Q000266:history / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy; D011188:Potassium / Q000266:history / Q000627:therapeutic use; D013903:Thoracic Surgery / Q000266:history
D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D005947:Glucose; D011188:Potassium