title: Hormonal status of male reproductive system: androgens and estrogens in the testis and epididymis. In vivo and in vitro approaches.
abstract: The purpose of this article was to summarize our results on the role of androgens and estrogens in human, rodent and equine testes and epididymides, in both, physiological and patological conditions, obtained in the space of the Solicited Project (084/PO6/2002) financially supported by the State Committee for Scientific Research during the last three years. Testosterone produced by Leydig cells of the testes is clearly the major androgen in the circulation of men and adult males of most mammalian species. However, androgen metabolites make up a significant fraction of total circulating steroids. Moreover, androgen metabolism may proceed to amplify the action of testosterone through its conversion to dihydrotestosterone (DHT) or its aromatization to estradiol. The distribution of androgen and estrogen receptors (ARs and ERs) within male reproductive tissues is important because of their crucial role in mediating androgen and/or estrogen action. Attempts were undertaken to discuss not only the role of aromatase and ERs in mediating the action of estrogens in the male, but also the importance of DHT in hormonal regulation of the epididymis. In the latter, alterations caused by finasteride treatment and lead-induced oxidative stress are described. Male reproductive function of the testis and epididymis reflected by the alterations in enzymatic activity, distribution of steroid hormone receptors, differences in steroid hormone levels and altered gene expression of antioxidant enzymes are also discussed.
authors.affiliation: Laboratory of Endocrinology and Tissue Culture, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland. bbili@zuk.iz.uj.edu.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Bilińska
authors.forename: Barbara
authors.initials: B
authors.lastname: Wiszniewska
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Kosiniak-Kamysz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kotula-Balak
authors.forename: Monika
authors.initials: M
authors.lastname: Gancarczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Hejmej
authors.forename: Jolanta
authors.initials: J
authors.lastname: Sadowska
authors.forename: Mariola
authors.initials: M
authors.lastname: Marchlewicz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kolasa
authors.forename: Lidia
authors.initials: L
authors.lastname: Wenda-Rózewicka
mesh_terms: D000728:Androgens / Q000378:metabolism*; D000818:Animals; D003456:Cryptorchidism; D004822:Epididymis / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008297:Male; D009154:Mutation; D011960:Receptors, Estrogen / Q000502:physiology; D011974:Receptors, LH / Q000502:physiology; D013737:Testis / Q000378:metabolism*
chemical_list: D000728:Androgens; D004967:Estrogens; D011960:Receptors, Estrogen; D011974:Receptors, LH