title: Early proteinuria is a strong indicator of donor renal lesions, ischemia-reperfusion injury and immunological aggression.
abstract: BACKGROUND
  Early proteinuria is associated with reduced long-term graft survival. However, the determinants and mechanisms of proteinuria early after transplantation have not been identified.
  
  
  METHODS
  Parameters associated with proteinuria within the first 3 months following transplantation were retrospectively assessed among 484 renal transplant recipients.
  
  
  RESULTS
  Proteinuria was more abundant in patients with a history of two or more rejection episodes (0.42 +/- 0.68 vs 0.18 +/- 0.39 g/d; P = .02). Proteinuria was greater when donor age was 60 or more (OR: 4.43; P = .003), when recipient death was due to cardiovascular causes (OR: 1.98; P = .002), or when cold (OR: 1.77; P = .006) or warm (1.21; P = .09) ischemia times were prolonged.
  
  
  CONCLUSIONS
  Proteinuria early after transplantation was related to pretransplant renal lesions, ischemia-reperfusion, and immunologic injuries.
authors.affiliation: François Rabelais University, Department of Nephrology and Clinical Immunology, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours cedex 9, France. halimi@med.univ-tours.fr
authors.forename: J
authors.initials: J
authors.lastname: Halimi
authors.forename: I
authors.initials: I
authors.lastname: Laouad
authors.forename: M
authors.initials: M
authors.lastname: Buchler
authors.forename: A
authors.initials: A
authors.lastname: Al-Najjar
authors.forename: V
authors.initials: V
authors.lastname: Chatelet
authors.forename: T S
authors.initials: TS
authors.lastname: Houssaini
authors.forename: H
authors.initials: H
authors.lastname: Nivet
authors.forename: Y
authors.initials: Y
authors.lastname: Lebranchu
mesh_terms: D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000097:blood; D006801:Humans; D007154:Immune System Diseases / Q000652:urine*; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology*; D015427:Reperfusion Injury / Q000652:urine*
chemical_list: D015415:Biomarkers; D003404:Creatinine