Transforming growth factor-beta: taking control of T cells' life and death.
To determine how transforming growth factor-beta (TGF-beta) controls T cell function, Marie et al. (2006) and Li et al. (2006a) created mice with T cells lacking TGF-beta signaling receptors. Both report that TGF-beta signaling by T cells is absolutely essential for tolerance and homeostasis.
Horwitz
David A
DA
Division of Rheumatology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D002470:Cell Survival / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta