Cushing's paraneoplastic syndrome as first manifestation of an adenocarcinoma of unknown origin.
Small cell lung cancer is the most common cause of paraneoplastic Cushing's syndrome. The definitive treatment consists in surgical removal of the tumour, which is not possible in most of these cases (they are often diagnosed at advanced stages), and therefore it is frequently necessary adding the drug ketoconazol. We hereby present the case of a patient diagnosed with a metastatic carcinoma of unknown origin associated with two paraneoplastic syndromes: a Cushing's syndrome and a sensitive-motor axonal neuropathy, a very uncommon association.
Molina Garrido
María José
MJ
Servicio de Oncología Médica, Hospital General Universitario de Elche, Alicante, Spain. mjmolinagarrido@hotmail.com
Guillén Ponce
Carmen
C
Maciá Escalante
Sonia
S
Pons Sanz
Vanesa
V
Carrato Mena
Alfredo
A
D000182:ACTH Syndrome, Ectopic / Q000209:etiology*; D000230:Adenocarcinoma / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis*; D020364:Paraneoplastic Polyneuropathy / Q000209:etiology*