title: Single particle friction on blister packaging materials used in dry powder inhalers.
abstract: Using atomic force microscopy (AFM) the adhesion and sliding friction behaviour of single lactose particles attached directly to AFM cantilevers has been studied. Measurements were made on the two sides of a blister packaging material used in dry powder inhalers (DPI). Although no significant differences in adhesion were observed, clear differences in particle friction were evident, where one side offers consistently greater friction across the range of loads studied here. The packaging samples were characterised by time-of-flight secondary ion mass spectrometry (ToF-SIMS) and X-ray photoelectron spectroscopy (XPS) and found to have different surface chemistries. The observed difference in friction behaviour is discussed in the context of the differences seen in surface chemistry, topography and hardness. It is reasoned that in this case hardness has the largest influence, and on one sample soft surface layers are displaced by the particle. A clear relationship between friction and load was only observed with one of the three particles tested; this was attributed to multiple asperities being brought into contact, illustrating the important role of nanoscale contact geometry in determining friction behaviour.
authors.affiliation: Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Bunker
authors.forename: Martyn C
authors.initials: MC
authors.lastname: Davies
authors.forename: Xinyong
authors.initials: X
authors.lastname: Chen
authors.forename: Michael B
authors.initials: MB
authors.lastname: James
authors.forename: Clive J
authors.initials: CJ
authors.lastname: Roberts
mesh_terms: D004349:Drug Packaging; D017276:Friction; D036501:Metered Dose Inhalers; D018625:Microscopy, Atomic Force; D011208:Powders; D013499:Surface Properties
chemical_list: D011208:Powders