title: Rectal malakoplakia presenting as a mass and fistulous tract in a renal transplant patient.
abstract: Malakoplakia (MK) is a rare, chronic inflammatory disorder with characteristic morphologic features. It most commonly involves urogenital organs but can affect any organ system in the body. Gastrointestinal tract is the second common site of involvement. It commonly occurs in nontransplant patients but transplant patients are also vulnerable to it. We present a case report of a forty year old male renal transplant patient, who received a kidney from his brother with 1 haplotype and 4 antigen match. He was on regular post transplant follow up with stable graft function. Fifteen months post transplant he presented with the complaint of painful defecation, a swelling in the perianal region and inability to sit down properly. Biopsy examination showed malakoplakia with characteristic Michaelis-Gutmann bodies. Culture of the tissue grew E Coli. Immunosuppression therapy was curtailed and patient was started on ciprofloxacin 500mg OD for 6 months. The lesions regressed completely after six months of the above therapy and the patient became completely symptoms free.
authors.affiliation: Department of Gastroenterology and Histopathology, Sindh Institute of Urology and Transplantation, Karachi.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yousif
authors.forename: Zaigham
authors.initials: Z
authors.lastname: Abbas
authors.forename: Muhammad
authors.initials: M
authors.lastname: Mubarak
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D005401:Fissure in Ano / Q000188:drug therapy; D005402:Fistula / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation; D008287:Malacoplakia / Q000473:pathology*; D008297:Male; D012003:Rectal Fistula / Q000188:drug therapy / Q000473:pathology*; D012007:Rectum / Q000473:pathology; D014181:Transplantation Immunology
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin