title: Pharmacology of ocular allergy.
abstract: OBJECTIVE
  To evaluate the pharmacology of current drug development directed towards ocular allergy. Increased worldwide prevalence of ocular allergy has stimulated expansion of management strategies towards physiologic and immunologic drug targets.
  
  
  RESULTS
  Present drug targets are located in the conjunctival mucosal surface at the initial site of allergen exposure. Pharmacologic intervention attends to early and late phase reactions. Targets generating a response include mast cells, IgE, released preformed mediator histamine, and newly formed mediators, such as prostaglandins, leukotrienes and cytokines. Methods to simulate allergy and measure efficacy of drugs are the conjunctival allergen challenge and the conjunctival provocation test. Pharmacologic outcome is measured via cytologic biomarkers and clinical signs/symptoms of redness, itching, lid swelling and chemosis. Endpoint instruments such as the Ocular Allergy Index and Eye Allergy Patient Impact Questionnaire have emerged from the field of pharmacoeconomics.
  
  
  CONCLUSIONS
  Important pharmacologic properties of targets have been revealed. First, histamine is more specifically antagonized by second generation antihistamines. Second, newly formed mediators and downstream responders (prostaglandins, leukotrienes, interleukins, intercellular adhesion molecule 1, tumor necrosis factor, vascular cell adhesion molecule, eosinophils and neutrophils) are more selectively antagonized by dual/multiple-action agents.
authors.affiliation: Clinical Pharmacology Department, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. bschultz@pco.edu
authors.forename: Beth Lillian
authors.initials: BL
authors.lastname: Schultz
mesh_terms: D003233:Conjunctivitis, Allergic / Q000188:drug therapy*; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans
chemical_list: D006633:Histamine Antagonists