title: Neurodevelopmental pathways to aggression: a model to understand and target treatment in youth.
abstract: The authors describe a neurodevelopmentally relevant, clinically derived model for understanding and treating aggressive behavior in youth. Based on case experience and literature review, the authors divide aggressive behavior into five symptomatic domains with respective neurobiological/neurodevelopmental underpinnings. These five symptom domains (impulsivity, affective instability, anxious/hyperarousal, cognitive disorganization, and predatory aggression) emerge as logical and clinically useful targets for treatment. The authors aim to establish a relationship between these symptom domains and brain structure and function that offers a clinically relevant approach to the complexities of understanding aggression and its treatment.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Sugden
authors.forename: Shawn J
authors.initials: SJ
authors.lastname: Kile
authors.forename: Robert L
authors.initials: RL
authors.lastname: Hendren
mesh_terms: D000293:Adolescent; D018663:Adrenergic Agents / Q000627:therapeutic use; D000374:Aggression / Q000502:physiology* / Q000523:psychology; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001007:Anxiety / Q000503:physiopathology; D001143:Arousal / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002648:Child; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007175:Impulsive Behavior / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D008297:Male; D019964:Mood Disorders / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D009420:Nervous System / Q000254:growth & development* / Q000503:physiopathology
chemical_list: D018663:Adrenergic Agents; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants