title: Floppy kid syndrome caused by D-lactic acidosis in goat kids.
abstract: BACKGROUND
  Goat kids with floppy kid syndrome have metabolic acidosis, muscle weakness, and depression but no dehydration.
  
  
  OBJECTIVE
  D-Lactate is the major component of acidemia in goat kids with floppy kid syndrome.
  
  
  METHODS
  Fifty-five goat kids with floppy kid syndrome (group F) and 35 clinically healthy goat kids (group C).
  
  
  METHODS
  Clinical, biochemical, microbiologic, virologic, parasitologic, and pathologic examinations.
  
  
  RESULTS
  The animals in group F had a blood pH of 7.13 +/- 0.11 and a base excess of -17.8 +/- 3.8 mM, which were both lower than the values in the control animals (pH, 7.32 +/- 0.31; base excess, -0.1 +/- 2.7 mM; P < .001). Floppy kids had a significantly larger anion gap than healthy kids (31.2 +/- 3.7 versus 21.5 +/- 8.5 mM; P < .001). The concentration of L-lactate was lower in floppy kids than in healthy kids (0.67 +/- 0.49 versus 1.60 +/- 1.02 mM), but the concentration of D-lactate was higher in floppy kids (7.43 +/- 2.71 versus 0.26 +/- 0.24 mM; P < .001). Intravenous and oral administration of sodium bicarbonate in floppy kids resulted in a significant increase in blood pH and base excess and a decrease in the anion gap (P < .001). In addition, the concentration of L-lactate increased (P = .039).
  
  
  CONCLUSIONS
  Metabolic acidosis in goat kids with floppy kid syndrome is caused by an increase in the plasma concentration of D-lactate.
authors.affiliation: Clinic of Reproductive Medicine, Vetsuisse-Faculty, University of Zurich, Switzerland. ubleul@vetclinics.unizh.ch
authors.forename: Ulrich
authors.initials: U
authors.lastname: Bleul
authors.forename: Silvia
authors.initials: S
authors.lastname: Schwantag
authors.forename: Hans
authors.initials: H
authors.lastname: Stocker
authors.forename: Louis
authors.initials: L
authors.lastname: Corboz
authors.forename: Felix
authors.initials: F
authors.lastname: Grimm
authors.forename: Monika
authors.initials: M
authors.lastname: Engels
authors.forename: Nicole
authors.initials: N
authors.lastname: Borel
authors.forename: Hans
authors.initials: H
authors.lastname: Lutz
authors.forename: Marietta
authors.initials: M
authors.lastname: Schönmann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kähn
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001774:Blood Chemical Analysis / Q000662:veterinary; D005260:Female; D015511:Goat Diseases / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D006041:Goats; D008297:Male; D012189:Retrospective Studies; D017693:Sodium Bicarbonate / Q000627:therapeutic use
chemical_list: D017693:Sodium Bicarbonate