Characteristics of bicalutamide solid dispersions and improvement of the dissolution.
The purpose of our study was to formulate and evaluate bicalutamide (BL) solid dispersions (SD). The physicochemical properties were evaluated by differential scanning calorimetry (DSC), Fourier-Transform infrared (FT-IR) spectroscopy, Powder X-ray diffractometry (PXRD), dissolution studies, and stability studies. The dissolution studies demonstrated that the dissolution of BL from BL-SD increased with an increase in carrier content (PVP K30). X-ray assays and DSC results both confirmed the amorphous state of BL in BL-SD. Stability studies conducted after 6 months showed that BL exhibited excellent stability in the solid dispersion of PVP K30 (1:5).
Ren
Fuzheng
F
Department of Pharmaceutical Engineering, School of Chemistry and Pharmaceutics, East China University of Science and Technology, Shanghai, 200237, China.
Jing
Qiufang
Q
Tang
Yanhui
Y
Shen
Yongjia
Y
Chen
Jialei
J
Gao
Feng
F
Cui
Jingbin
J
D000813:Anilides / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D004355:Drug Stability; D009570:Nitriles; D011145:Polyvinyls / Q000008:administration & dosage*; D011208:Powders; D011759:Pyrrolidines / Q000008:administration & dosage*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014105:Tosyl Compounds; D014961:X-Ray Diffraction
D000813:Anilides; D004337:Drug Carriers; D009570:Nitriles; D011145:Polyvinyls; D011208:Powders; D011759:Pyrrolidines; D014105:Tosyl Compounds; C505150:poly(N-vinylpyrrolidine); C053541:bicalutamide