title: Modelling dynamics of the type I interferon response to in vitro viral infection.
abstract: Innate immunity is crucial in the early stages of resistance to novel viral infection. The family of cytokines known as the interferons (IFNs) forms an essential component of this system: they are responsible for signalling that an infection is underway and for promoting an antiviral response in susceptible cells. We construct a spatial stochastic model, parameterized by experimental data and informed by analytic approximation, to capture the dynamics of virus-IFN interaction during in vitro infection of Madin-Darby bovine kidney cell monolayers by Herpes simplex virus 1. The dose dependence of infection progression, subsequent monolayer destruction and IFN-beta production are investigated. Implications for in vivo infections, in particular the priming of susceptible cells by IFN-beta during infection, are considered.
authors.affiliation: Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. tjh44@cam.ac.uk
authors.forename: Tom J
authors.initials: TJ
authors.lastname: Howat
authors.forename: Cristina
authors.initials: C
authors.lastname: Barreca
authors.forename: Peter
authors.initials: P
authors.lastname: O'Hare
authors.forename: Julia R
authors.initials: JR
authors.lastname: Gog
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Grenfell
mesh_terms: D000818:Animals; D002417:Cattle; D002460:Cell Line; D002522:Chlorocebus aethiops; D003198:Computer Simulation; D018259:Herpesvirus 1, Human / Q000276:immunology*; D007370:Interferon Type I / Q000276:immunology* / Q000378:metabolism*; D007668:Kidney / Q000166:cytology; D018448:Models, Immunological; D013269:Stochastic Processes
chemical_list: D007370:Interferon Type I