Studies on condensed 1,4-dihydropyridine derivatives and their calcium modulatory activities.
Hexahydroquinoline and furoquinoline derivatives were synthesized and their calcium modulatory activity was investigated on isolated rat ileum and lamb carotid artery. In addition, the in vitro hepatic microsomal biotransformation of one hexahydroquinoline derivative was studied in rat microsomes.
Aydin
F
F
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Safak
C
C
Simşek
R
R
Erol
K
K
Ulgen
M
M
Linden
A
A
D000818:Animals; D001711:Biotransformation; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D008958:Models, Molecular; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D015363:Quinolones / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D012756:Sheep; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D007202:Indicators and Reagents; D015363:Quinolones