The treatment of patients with factor-V deficiency.
Two patients with congenital factor-V deficiency and a third with a combined deficiency of factor V and factor VIII are described. Under cover of fresh frozen plasma, tooth extractions were performed on two of these patients and spontaneous bleeding arrested. It is concluded that the achievement of a blood level of factor V of 20 per cent once daily is sufficient to assure adequate haemostasis. A low recovery of factor V activity in the plasma following infusion was found. However, in spite of this, adequate blood levels were easily attained due to the excellent preservation of factor V activity in the stored fresh frozen plasma.
Rush
B
B
Medical Research Council, Blood Coagulation Research Unit, Churchill Hospital, Oxford.
Ellis
H
H
D001760:Bleeding Time; D001777:Blood Coagulation; D016913:Blood Component Transfusion; D002648:Child; D005166:Factor V Deficiency / Q000097:blood* / Q000628:therapy*; D006801:Humans; D008297:Male; D010949:Plasma