[Physiology of innate immunity].
The mechanisms of innate immunity functioning--the first row of counteraction (resistance) to infectious agents are reviewed. A concept of pathogen associated molecular patterns--the unique prokaryotic conservative structures--as well as a concept of pattern-recognizing receptors of innate immunity cell recognizing the given bacterial patterns, are discussed. The data on molecular and genetic structures of both Toll-like- and NOD-receptors: the important compounds of pattern-recognizing receptors, the main signaling pathways from receptor to cell genome activation as well as the principles of immune cell activation by pathogen associated molecular patterns are submitted.
Khaitov
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D000818:Animals; D001419:Bacteria / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000502:physiology*; D014780:Viruses / Q000276:immunology
D047908:Intracellular Signaling Peptides and Proteins; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors