[Development of anti-dementia drugs related to neurotrophic factors].
Neurotrophic factor-like substances and inducers of neurotrophic factor biosynthesis have enormous therapeutic potential for serious neuronal diseases such as Alzheimer's disease. Here, we discuss about the pharmacological effects of scabronines and beta-eudesmol as promising candidates of leading compounds against the dementia. In addition, we discuss about the signaling pathway of nerve growth factor and cyclic AMP in order to seek the signaling molecules as targets of drug development.
Obara
Yutaro
Y
Department of Cellular Signaling and 21st Century COE Program CRESCENDO, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai City, Japan. obaray@mail.pharm.tohoku.ac.jp
D000242:Cyclic AMP / Q000502:physiology; D003704:Dementia / Q000188:drug therapy*; D004224:Diterpenes / Q000494:pharmacology; D015195:Drug Design; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane / Q000494:pharmacology; D015398:Signal Transduction
D004224:Diterpenes; D009414:Nerve Growth Factors; D018697:Nootropic Agents; D045787:Sesquiterpenes, Eudesmane; C119786:scabronine A; C119787:scabronine G; C051082:beta-eudesmol; D000242:Cyclic AMP; D048049:Extracellular Signal-Regulated MAP Kinases