Appetite suppression through delayed fat digestion.
High-fat diets are often associated with greater caloric intake and weight gain. Since satiety during fat intake is induced by fat in the intestine we investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absence of steatorrhea is explained by an increased pancreatic lipase/colipase secretion, compensating the impaired lipolysis by the added compound. The animals also had an elevated CCK secretion. The satiety for fat may be the consequence of elevated CCK and procolipase/enterostatin levels. We conclude that compounds can be found that delay intestinal fat digestion and control high-fat food intake through the release of satiety signals, without causing steatorrhea. The absence of steatorrhea makes such compounds advantageous over lipase inhibitors in the treatment of obesity.
Mei
Jie
J
Division of Diabetes, Endocrinology and Metabolism, Department of Experimental Medical Science, BMC F13, Lund University, S-221 84 Lund, Sweden.
Lindqvist
Andreas
A
Krabisch
Lennart
L
Rehfeld
Jens F
JF
Erlanson-Albertsson
Charlotte
C
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology; D001069:Appetite Regulation / Q000187:drug effects* / Q000502:physiology; D003089:Colipases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism*; D004063:Digestion / Q000187:drug effects / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004987:Ethers / Q000494:pharmacology*; D005260:Female; D007783:Lactones / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008066:Lipolysis / Q000187:drug effects* / Q000502:physiology; D000077403:Orlistat; D051381:Rats; D017207:Rats, Sprague-Dawley; D012527:Satiation / Q000502:physiology; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D001067:Appetite Depressants; D003089:Colipases; D004041:Dietary Fats; D004791:Enzyme Inhibitors; D004987:Ethers; D007783:Lactones; D014280:Triglycerides; C515771:dimethylaminoethyl dodecyl ether; D000077403:Orlistat; D008049:Lipase