title: Attenuation-corrected 99mTc-MIBI SPECT in overweight patients with chronic ischaemic dysfunction: a comparison to NH3 PET and implications for the diagnosis of myocardial viability.
abstract: OBJECTIVE
  We determined the value of attenuation correction (AC) of myocardial perfusion estimation with (99m)Tc-MIBI SPECT in overweight patients by comparison of uncorrected (filtered back-projection (FBP) and corrected (an iterative algorithm with a measured attenuation coefficients map (FL-AC)) (99m)Tc-MIBI relative uptake to perfusion data obtained in the same patients with NH3 PET. In addition, the impact of attenuation correction for the assessment of myocardial viability with (99m)Tc-MIBI SPECT was determined using FDG PET as the reference method.
  
  
  METHODS
  Thirty consecutive overweight patients (BMI=28+/-4) with left ventricular dysfunction underwent a resting (99m)Tc-MIBI SPECT and a PET study (NH3 and FDG). (99m)Tc-MIBI SPECT scans were reconstructed without attenuation correction (FBP) and with attenuation correction (FL-AC). The left ventricle was divided into 16 segments, in which the relative uptake was quantified using circumferential profiles. A relative uptake > or = 60% was considered consistent with viable myocardium for FDG and MIBI.
  
  
  RESULTS
  The absolute difference between (99m)Tc-MIBI SPECT and NH3 PET uptakes was less pronounced in the inferior (12+/-10% vs. 17+/-12%, P<0.001), anteroseptal (12+/-11% vs. 16+/-12%, P=0.009) and septal (15+/-12% vs. 18+/-14%, P=0.003) regions (FL-AC vs. FBP, respectively). The sensitivity of MIBI for diagnosing myocardial viability increased from 83 to 100% (P=0.034), without loss in specificity.
  
  
  CONCLUSIONS
  Attenuation correction improves myocardial perfusion estimation by (99m)Tc-MIBI SPECT in the inferior, anteroseptal and septal regions and increases its sensitivity for the diagnosis of myocardial viability.
authors.affiliation: Department of Nuclear Medicine, Cliniques Universitaires St-Luc, Université Catholique de Louvain, Brussels, Belgium. veronique.roelants@imre.ucl.ac.be
authors.forename: Véronique
authors.initials: V
authors.lastname: Roelants
authors.forename: Xavier
authors.initials: X
authors.lastname: Bernard
authors.forename: Stephan
authors.initials: S
authors.lastname: Walrand
authors.forename: Anne
authors.initials: A
authors.lastname: Bol
authors.forename: Ann
authors.initials: A
authors.lastname: Coppens
authors.forename: Jacques
authors.initials: J
authors.lastname: Jamart
authors.forename: Jacques
authors.initials: J
authors.lastname: Melin
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Vanoverschelde
mesh_terms: D000465:Algorithms; D003326:Coronary Circulation; D004452:Echocardiography / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007511:Ischemia / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D050177:Overweight; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D018487:Ventricular Dysfunction, Left
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi