title: The phenotype of normal, reactive and malignant plasma cells. Identification of "many and multiple myelomas" and of new targets for myeloma therapy.
abstract: The aim of this review is to integrate non-exhaustive relevant data on the phenotype of human plasma cells (PC), including normal, reactive and malignant (multiple myeloma, MM) PC. This review focuses on (i) a universal marker of both normal and malignant plasma cells, CD138; (ii) markers related to malignancy i.e., CD19, CD27, CD28, and CD56; (iii) markers associated with signaling and severity of MM (CD45, CD221). Finally, this review presents data from normal PC up to human myeloma cell lines in order to: (i) define different entities of MM based on expression of CD19, CD20, CD27 and CD117; and (ii) identify new therapeutic targets.
authors.affiliation: INSERM, U601, Nantes, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Bataille
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Jégo
authors.forename: Nelly
authors.initials: N
authors.lastname: Robillard
authors.forename: Sophie
authors.initials: S
authors.lastname: Barillé-Nion
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Harousseau
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.forename: Martine
authors.initials: M
authors.lastname: Amiot
authors.forename: Catherine
authors.initials: C
authors.lastname: Pellat-Deceunynck
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D016130:Immunophenotyping; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology*; D010950:Plasma Cells / Q000166:cytology / Q000473:pathology
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor