title: The relationship of medical comorbidity and depression in older, primary care patients.
abstract: Comorbid medical illnesses are a key feature of geriatric mood disorders, yet the specificity of such associations remains unclear. In a sample of 546 primary care patients age >or=65 years, pathology in several organ systems (respiratory, eye/ear/nose/throat, gastrointestinal, central nervous system, endocrine) and several chronic conditions (neurological disease, low vision, chronic obstructive pulmonary disease, diabetes) were associated with depression. However, notwithstanding these specific associations, global (overall) medical burden was most powerfully and independently associated with depression, largely independent of functional status. This generates the hypothesis that, in general primary care populations, the relationship of medical illness to depression may be multimodal and/or may involve shared pathobiological or psychosocial mechanisms.
authors.affiliation: Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd., Rochester, NY 14642, USA. Jeffrey_Lyness@urmc.rochester.edu
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Lyness
authors.forename: Aurelian
authors.initials: A
authors.lastname: Niculescu
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.forename: Charles F
authors.initials: CF
authors.lastname: Reynolds
authors.forename: Eric D
authors.initials: ED
authors.lastname: Caine
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology; D002908:Chronic Disease; D015897:Comorbidity; D017281:Cost of Illness; D003866:Depressive Disorder / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D011320:Primary Health Care; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012720:Severity of Illness Index