TRAIL, caspases and maturation of normal and leukemic myeloid precursors.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) is a membrane-bound cytokine molecule that belongs to the family of tumor necrosis factor (TNF). Members of this family share diverse biological effects, including induction of apoptosis and/or promotion of cell survival. Identification of TRAIL has generated considerable enthusiasm for its ability to induce apoptotic cell death in a variety of tumor cells, by engaging the death receptors TRAIL-R1/DR4 and TRAIL-R2/DR5, while sparing most normal cells. Beside its anticancer activity, several studies have suggested a role for endogenously expressed TRAIL in hemopoiesis. In this review, we summarize the knowledge about the different lineage-specific roles of TRAIL and its receptors in hemopoiesis regulation. Moreover, the complex interplay among the signaling pathways triggered by TRAIL/TRAIL-receptors in myeloid cells is discussed in some detail.
Corallini
Federica
F
Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 66, 44100, Ferrara, Italy.
Milani
Daniela
D
Nicolin
Vanessa
V
Secchiero
Paola
P
D017209:Apoptosis; D020169:Caspases / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D023461:Myeloid Progenitor Cells / Q000166:cytology*; D014411:Neoplastic Stem Cells / Q000473:pathology*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000502:physiology*
D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D020169:Caspases