An internal clock generates repetitive predictive saccades.
Previously we demonstrated the presence of a behavioral phase transition between reactive and predictive eye tracking of alternating targets. Prior studies of repetitive movements have proposed that an "internal clock" is the neural mechanism by which interval timing is achieved. In the present report we tested whether predictive oculomotor (saccade) tracking is based on an internal time reference (clock) by examining the effect of transient perturbations to the periodic pacing stimulus. These perturbations consisted of altering the timing of the stimulus (abruptly increasing or decreasing the inter-stimulus interval) or extinguishing the targets altogether. Although reactive tracking (at low pacing rates) was greatly affected by these timing perturbations, once predictive tracking was established subjects continued to time their eye movement responses at the pre-existing rate despite the perturbation. As expected from certain clock models, inter-stimulus intervals for predictive tracking followed Weber's law and the scalar property (timing variability increases in proportion to interval duration), but this was not true for reactive tracking. In addition, the perturbation results show that subjects can establish an internal representation of target pacing (the internal clock) in as little as two eye-movement intervals, which suggests that this mechanism is relevant for real-world situations. These findings are consistent with the presence of an internal clock for the generation of these predictive movements, and demonstrate that the neural mechanism responsible for this behavior is temporally accurate and flexible.
Joiner
Wilsaan M
WM
Department of Biomedical Engineering, The Johns Hopkins University, School of Medicine, 720 Rutland Avenue/606 Traylor Bldg, Baltimore, MD 21205, USA. wjoiner@bme.jhu.edu
Shelhamer
Mark
M
D006801:Humans; D008959:Models, Neurological; D009039:Motion Perception / Q000502:physiology*; D010775:Photic Stimulation; D011237:Predictive Value of Tests; D011597:Psychomotor Performance; D011698:Pursuit, Smooth / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*