Growth factor delivery for oral and periodontal tissue engineering.
The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. Growth factors are critical to the development, maturation, maintenance and repair of craniofacial tissues, as they establish an extracellular environment that is conducive to cell and tissue growth. Tissue-engineering principles aim to exploit these properties in the development of biomimetic materials that can provide an appropriate microenvironment for tissue development. These materials have been constructed into devices that can be used as vehicles for delivery of cells, growth factors and DNA. In this review, different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral- and tooth-supporting structures, namely the periodontium and alveolar bone.
Kaigler
Darnell
D
Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Cirelli
Joni A
JA
Giannobile
William V
WV
D000818:Animals; D000077214:Becaplermin; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage; D016503:Drug Delivery Systems; D015316:Genetic Therapy; D006133:Growth Substances / Q000008:administration & dosage*; D006801:Humans; D009059:Mouth Diseases / Q000628:therapy*; D010510:Periodontal Diseases / Q000628:therapy*; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins / Q000008:administration & dosage; D023822:Tissue Engineering; D016212:Transforming Growth Factor beta / Q000008:administration & dosage; D014945:Wound Healing
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D000077214:Becaplermin