[Evaluation of anti-blastoma effects of tetravaccine in combination with chemotherapy].
The present work discusses methods of immune-correction and immune-rehabilitation of oncological patients using specific bacterial polyvalent vaccines. With this purpose the tetra-vaccine (Staphilococcus-Proteus-Clepsiela-Escherichia) has been used. Experiments have been carried out on white rats and mice with Sarcoma C-45. For chemotherapy of malignant tumors the following remedies were used: Cyclophosphan, Vincristin and Adriablastin. The vaccine and chemotherapy were applied in both ways, separately (control), and in combination. The results of investigations have shown that the best effect was achieved in case of combination of vaccine with chemotherapy--particularly, in the first experimental series malignant tumors completely underwent regression, while using only tetra-vaccine, the percent of malignant tumor growth inhibition constituted only 37.6%, and in the second experimental series percent of tumor growth inhibition constituted 56%-100% and the life span was prolonged by 22.4%-54.6%. Thus, the received results are quite encouraging and suggested method could be used for treatment of patients with cancer.
Khorava
P A
PA
Gambashidze
K G
KG
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000276:immunology*; D023041:Xenograft Model Antitumor Assays
D001428:Bacterial Vaccines