Reserpine-induced model of stress suppresses mucosal immunity.
Stress contributes significantly to the development of many diseases. In clinical studies, a strong correlation between depression and immune dysfunction has been shown. Our previous studies indicated that sympathetic innervation can regulate intestinal mucosal immunity through sympathetic synapses, but the mechanism in stress/depression-induced intestinal immune deficiency was unclear. Using a mouse model in which behavioural stress/depression is chemically induced by reserpine, it is found that there is a substantial deficiency of intestinal local humoral and particularly specific antibody response to the antigen stimulation in reserpine-treated group. No significant difference of CD4+, CD8+ or Mac1+ cells between reserpine-treated and control groups was detected in the intestine. This deficiency is closely correlated with stress/depression. A possible correlation between stress, cytokine secretion and humoral immunity in vivo is postulated.
Bao
Shisan
S
The Third People's Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China. bobbao@med.usyd.edu.au
Fei
Jian
J
Shen
Jie
J
Gong
Sheng J
SJ
Fang
Huang
H
Husband
Alan J
AJ
D000818:Animals; D000917:Antibody Formation; D014150:Antipsychotic Agents / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018928:Immunity, Mucosal; D007136:Immunoglobulins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology*; D051379:Mice; D008954:Models, Biological; D010047:Ovalbumin / Q000276:immunology / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology*; D013315:Stress, Psychological / Q000139:chemically induced*
D014150:Antipsychotic Agents; D007136:Immunoglobulins; D012110:Reserpine; D010047:Ovalbumin