[Reproductive dysfunctions in female patients during therapy with atypical antipsychotics].
To specify interrelations between clinical and hormonal aspects of reproductive dysfunctions appearing during therapy with atypical antipsychotic agents (clozapine, olanzapine, quetiapine), 131 female patients with paranoid schizophrenia and schizoaffective disorder have been studied. Distinctive features of dynamics of prolactin as well as hypothalamic-pituitary-gonadal hormones levels for each medication studied and correlations between hormone indices and clinical presentations of reproductive dysfunctions (galactorrhea, disturbances of menstrual cycle and libido) were found.
Gorobets
L N
LN
Ermolaeva
L G
LG
Litvinov
A V
AV
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011388:Prolactin / Q000097:blood; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*; D012559:Schizophrenia / Q000188:drug therapy*; D012720:Severity of Illness Index; D012735:Sexual Dysfunction, Physiological / Q000097:blood / Q000139:chemically induced*
D014150:Antipsychotic Agents; D011388:Prolactin