Synthesis and antihyperlipidemic activity of novel glycosyl fructose derivatives.
A series of novel di and trisaccharide derivatives containing d-fructose moiety at the reducing end have been synthesized and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model. Among 11 glycosyl fructose derivatives five compounds showed potent antihyperlipidemic activity either by enhancing high-density lipoprotein (HDL) cholesterol concentration and/or lowering triglyceride (TG) level.
Tiwari
Pallavi
P
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.
Puri
Anju
A
Chander
Ramesh
R
Bhatia
Geetika
G
Misra
Anup Kumar
AK
D000818:Animals; D002236:Carbohydrate Conformation; D006224:Cricetinae; D005632:Fructose / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D006031:Glycosylation; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000960:Hypolipidemic Agents; D005632:Fructose