Lung diseases in patients with common variable immunodeficiency: chest radiographic, and computed tomographic findings.
OBJECTIVE
To evaluate chest radiographic and computed tomographic (CT) findings of lung disease related to common variable immunodeficiency.


METHODS
Thirty-five chest radiographs and 30 CT scans of 46 patients were assessed. Lung parenchymal abnormalities that were evaluated included airspace consolidation, ground-glass attenuation, nodules, bronchiectasis, and air trapping.


RESULTS
On CT, ground-glass attenuation and nodules were the most frequent findings, observed in 60% (n = 18/30) and 83% (n = 25/30), respectively. Three major CT patterns were identified: airway disease (n = 13), nodules (n = 8), and parenchymal opacification (n = 6). All 13 patients with airway disease showed centrilobular opacities. One patient with peribronchial nodules showed lymphoid interstitial pneumonia, and 1 with randomly distributed nodules showed noncaseating granulomas. Patients with a CT pattern of parenchymal opacification showed lower lung predominance; surgical biopsies showed organizing pneumonia in 1 patient and lymphoid interstitial pneumonia with nonnecrotizing granulomas in another.


CONCLUSIONS
Common variable immunodeficiency is associated with 3 major CT patterns: airway disease, nodules, and parenchymal opacification.
Tanaka
Nobuyuki
N
Department of Radiology , University of Colorado Health Sciences Center, Denver, CO, USA.
Kim
Jeung Sook
JS
Bates
Christopher A
CA
Brown
Kevin K
KK
Cool
Carlyne D
CD
Newell
John D
JD
Lynch
David A
DA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D017074:Common Variable Immunodeficiency / Q000150:complications*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008171:Lung Diseases / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011014:Pneumonia / Q000150:complications / Q000175:diagnosis; D012129:Respiratory Function Tests / Q000379:methods; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*