Increased risk of papillary thyroid cancer in celiac disease.
Patients with celiac disease have an increased rate of malignancies that are not limited to lymphomas. Thyroid carcinoma has not previously been associated with celiac disease. However, among a cohort of patients with celiac disease, we identified an increased risk of papillary carcinoma of the thyroid, standard morbidity ratio of 22.52 (95% confidence interval 14.90-34.04; P < .001), compared to United States national surveillance data. These patients were on a gluten-free diet. Only 1 had Hashimoto's thyroiditis, suggesting that mechanisms apart from autoimmune thyroiditis contribute to the increased risk of carcinoma of the thyroid in celiac disease.
Kent
Laura
L
Department of Medicine, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, Room 645, New York, 10032 New York, USA.
McBride
Russell
R
McConnell
Robert
R
Neugut
Alfred I
AI
Bhagat
Govind
G
Green
Peter H R
PH
D000328:Adult; D002291:Carcinoma, Papillary / Q000453:epidemiology*; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment; D018426:SEER Program; D013964:Thyroid Neoplasms / Q000453:epidemiology*; D013997:Time Factors; D014481:United States / Q000453:epidemiology