Immune globulin IV therapy: optimizing care of patients in the oncology setting.
OBJECTIVE
To review major clinical applications of immune globulin IV (IGIV) therapy, properties of currently available IGIV preparations, procedures for dosing and administration, management of infusion-related adverse effects, and strategies for effective patient education.


METHODS
Published articles, abstracts, and textbook chapters.


RESULTS
IGIV therapy supports immune function by providing immunoglobulin G antibodies for protection against pathogens and modulation of autoimmune and other potentially damaging host responses. Licensed uses include treatment of primary immune deficiencies and autoimmune conditions and prophylaxis against viral infection.


CONCLUSIONS
The safety and effectiveness of IGIV therapy depend on selection of an appropriate product, dosage, and infusion rate; patient comorbidities and other risk factors; and patient education and treatment adherence.


CONCLUSIONS
Nurses have an essential role in the safe and effective use of IGIV, from educating patients about the rationale for and effects of therapy to administering the product and monitoring for adverse effects.
Shelton
Brenda K
BK
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD, USA. sheltbr@jhmi.edu
Griffin
Julia M
JM
Goldman
Frederick D
FD
D000328:Adult; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009369:Neoplasms / Q000276:immunology / Q000451:nursing*; D024802:Nurse's Role; D010349:Patient Compliance; D010353:Patient Education as Topic
D016756:Immunoglobulins, Intravenous