title: [Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice].
abstract: OBJECTIVE
  To observe the effects of ethanol extracts of Panax notoginseng on the tumor and the liver metastasis in experimental mice grafted with B16 melanoma.
  
  
  METHODS
  B16 melanoma was transplanted in the spleen of C57BL/6 mice. The effects of different doses of ethanol extracts of Panax notoginseng on the inhibition rate of spleen tumors and the liver metastasis were observed respectively.
  
  
  RESULTS
  The high-, medium-, and low-doses of the extracts and the interferon-alpha (IFN-alpha) can improve the quality of life of the experimental mice. The weights of spleen tumor were lower in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the normal saline (NS)-treated group (P<0.05 or P<0.01). The liver metastasis was less in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the NS-treated group (P<0.01).
  
  
  CONCLUSIONS
  The ethanol extracts of Panax notoginseng can improve the quality of life of the experimental mice and inhibit the growth of tumor and the liver metastasis.
authors.affiliation: Department of Oncology, First Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang Province 310006, China. cpf12345@163.com
authors.forename: Pei-Feng
authors.initials: PF
authors.lastname: Chen
authors.forename: Lu-Ming
authors.initials: LM
authors.lastname: Liu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Chen
authors.forename: Sheng-You
authors.initials: SY
authors.lastname: Lin
authors.forename: Wei-Xiang
authors.initials: WX
authors.lastname: Song
authors.forename: Ying-Fei
authors.initials: YF
authors.lastname: Xu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D000431:Ethanol / Q000737:chemistry; D005260:Female; D016898:Interferon-alpha / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D053723:Panax notoginseng / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D011897:Random Allocation; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D016898:Interferon-alpha; D010936:Plant Extracts; D000431:Ethanol