title: Caffeic acid protects hydrogen peroxide induced cell damage in WI-38 human lung fibroblast cells.
abstract: Cytoprotective effect of caffeic acid (3,4-dihydroxy cinnamic acid) on human lung fibroblast (WI-38) cells against hydrogen peroxide induced damage was investigated. Caffeic acid was found to scavenge intracellular reactive oxygen species, and 1,1-diphenyl-2-picrylhydrazyl radical, and thus prevented lipid peroxidation. The caffeic acid protected cell damage of WI-38 cells exposed to hydrogen peroxide (H(2)O(2)), via the activation of extracellular signal regulated kinase protein. Caffeic acid increased the activity of catalase and its protein expression. Hence, from the present study, it is suggestive that caffeic acid protects WI-38 cells against H2O2 damage by enhancing the cellular antioxidant activity.
authors.affiliation: Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, Korea.
authors.forename: Kyoung Ah
authors.initials: KA
authors.lastname: Kang
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Lee
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Meijing
authors.initials: M
authors.lastname: Piao
authors.forename: Sungwook
authors.initials: S
authors.lastname: Chae
authors.forename: Kil Nam
authors.initials: KN
authors.lastname: Kim
authors.forename: You Jin
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Doek Bae
authors.initials: DB
authors.lastname: Park
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: You
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Kim
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
mesh_terms: D002109:Caffeic Acids / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D002478:Cells, Cultured; D019610:Cytoprotection; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000187:drug effects
chemical_list: D002109:Caffeic Acids; D016166:Free Radical Scavengers; D006861:Hydrogen Peroxide; D002374:Catalase; D048049:Extracellular Signal-Regulated MAP Kinases; C040048:caffeic acid