title: Glucose metabolites in the striatum of freely behaving rats following infusion of elevated potassium.
abstract: The outcome of patients with traumatic brain injury (TBI) can be predicted by the extracellular potassium concentration and the change in energy homeostasis. In this study, the authors investigated the effects of high potassium concentrations on extracellular levels of glucose, pyruvate and lactate in the rat striatum. Applying artificial cerebrospinal fluid (ACSF) enriched with 120 mM potassium by reverse microdialysis leads to an increase in lactate and reduction in glucose and pyruvate. Consequently, the lactate to pyruvate ratio was also increased. These data are discussed in the context of recent studies on lactate/pyruvate conversion and the potential mechanisms whereby high potassium could affect this equilibrium. We conclude that ischemic-like events are unlikely to explain these K(+)-induced changes.
authors.affiliation: Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA. olivier@darbin.com
authors.forename: Olivier
authors.initials: O
authors.lastname: Darbin
authors.forename: Emily
authors.initials: E
authors.lastname: Carre
authors.forename: Dean
authors.initials: D
authors.lastname: Naritoku
authors.forename: Jean Jacque
authors.initials: JJ
authors.lastname: Risso
authors.forename: Michel
authors.initials: M
authors.lastname: Lonjon
authors.forename: Peter R
authors.initials: PR
authors.lastname: Patrylo
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid; D005947:Glucose; D011188:Potassium