Mutant p53 gain of function: the NF-Y connection.
The molecular mechanisms underlying mutant p53 gain of function are becoming increasingly complex. In this issue of Cancer Cell, Di Agostino et al. identify the heterotrimeric transcription factor NF-Y as an interacting partner of mutant p53. They show that mutant p53/NF-Y complexes bind to NF-Y target promoters and recruit p300 in response to DNA damage, resulting in aberrant transactivation of NF-Y target genes and cell cycle deregulation. These data thereby implicate transcriptional activation by mutant p53 as a key mechanism responsible for its oncogenic activity.
Peart
Melissa J
MJ
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Prives
Carol
C
D023081:CCAAT-Binding Factor / Q000378:metabolism*; D006801:Humans; D009154:Mutation / Q000235:genetics; D011485:Protein Binding; D014158:Transcription, Genetic / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D023081:CCAAT-Binding Factor; D016159:Tumor Suppressor Protein p53