title: Gastric hepatoid adenocarcinoma with autophagy-related necrosis-like tumor cell death: report of a case.
abstract: A case of hepatoid adenocarcinoma of the stomach is presented. The characteristic features of the tumor are summarized on the basis of the authors' experience and the literature. Ultrastructural examination revealed patchy condensations of chromatin throughout the nucleus suggestive of necrosis-like programmed cell death (PCD). These nuclear alterations were associated with the occurrence of vacuoles and lipofuscins, conferring an autophagic phenotype to this PCD. Thus, the case reported here provides an example of autophagic-related necrosis-like PCD. Alternative PCDs are reviewed and their morphologic distinction is discussed.
authors.affiliation: Departimento di Patologia Umana, Policlinico Universitario, Messina, Italy. Rosariocaruso@tin.it
authors.forename: R A
authors.initials: RA
authors.lastname: Caruso
authors.forename: F
authors.initials: F
authors.lastname: Basile
authors.forename: F
authors.initials: F
authors.lastname: Fedele
authors.forename: V
authors.initials: V
authors.lastname: Zuccalà
authors.forename: C
authors.initials: C
authors.lastname: Crisafulli
authors.forename: M G
authors.initials: MG
authors.lastname: Fracassi
authors.forename: E
authors.initials: E
authors.lastname: Quattrocchi
authors.forename: A
authors.initials: A
authors.lastname: Venuti
authors.forename: V
authors.initials: V
authors.lastname: Fabiano
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D000368:Aged; D001343:Autophagy; D022781:Hepatocytes / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D000509:alpha-Fetoproteins / Q000096:biosynthesis
chemical_list: D000509:alpha-Fetoproteins