title: SPEED: a molecular-evolution-based database of mammalian orthologous groups.
abstract: BACKGROUND
  The abundance of nucleotide sequence information available has expanded horizons of inquiry for molecular evolution; however, the full potential of whole-genome analysis has not been realized because of inadequate tools. Here, we present one of the first toolkits to aid multidisciplinary high-throughput analysis.
  
  
  CONCLUSIONS
  SPEED was created to integrate molecular evolutionary data with existing genetic resources and provide a straightforward user interface to 17,352 orthologous gene groups, containing representatives from eight mammalian species and an avian outgroup.
  
  
  BACKGROUND
  See http://bioinfobase.umkc.edu/speed/ for access.
authors.affiliation: Department of Human Genetics and Committee on Genetics, Howard Hughes Medical Institute, University of Chicago 920 East 58th Street, Chicago, IL 60637, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Vallender
authors.forename: Justin E
authors.initials: JE
authors.lastname: Paschall
authors.forename: Christine M
authors.initials: CM
authors.lastname: Malcom
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Lahn
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Wyckoff
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D030562:Databases, Protein; D019143:Evolution, Molecular; D016678:Genome; D006801:Humans; D010802:Phylogeny; D016415:Sequence Alignment; D012984:Software