[A case of systemic amyloidosis treated by chemotherapy with autologous peripheral blood stem cell transplantation].
A 67-year-old woman was admitted to our hospital because of breathlessness. Systemic amyloidosis had been diagnosed 5 years previously. Her chest X-ray film showed multiple nodules in both lung fields. Chest computed tomography (CT) revealed some of the nodules had calcifications. Bronchoscopy demonstrated amyloid deposits in the bronchial walls. The serum titer of anti-SS-A antibody was high. Results of both the Schirmer Test and the Rose-Bengal Test were positive. The final diagnosis was systemic amyloidosis with Sjögren's syndrome. She was treated by chemotherapy using high dose melphalan with autologous peripheral blood stem cell transplantation (PBSCT). It was obvious that her chest X-ray film findings and bronchoscopic findings had improved 9 months after high dose chemotherapy with PBSCT. The disappearance of M protein and improvement of thirst, a symptom of Sjögren's syndrome, were also observed.
Mito
Akiko
A
Department of Respiratory Disease, Hiroshima Red Cross Hospital Atomic Bomb Survirvors Hospital.
Daga
Haruko
H
Ohashi
Nobuyuki
N
Akita
Shin
S
Shiomi
Keiji
K
Arita
Ken-ichi
K
Fujiwara
Megumu
M
Asaoku
Hideki
H
D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage*; D036102:Peripheral Blood Stem Cell Transplantation; D012859:Sjogren's Syndrome / Q000150:complications*; D003074:Solitary Pulmonary Nodule / Q000150:complications / Q000188:drug therapy; D014182:Transplantation, Autologous; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D008558:Melphalan