title: Giant cell tumor of the nasal cavity: case report.
abstract: Soft tissue giant cell tumor of low malignant potential is a rare tumor located in superficial and deep soft tissue. Tumors with osteoclast-like giant cells have been reported in various sites as breast, salivary glands, lung, kidney and pancreas. These tumors are composed of evenly spaced multinucleated giant cells in a background of mononuclear component composed of round, oval or spindled cells. No atypia or significant mitotic activity is encountered. Immunohistochemical stains for TRAP, smooth muscle actin, desmin and cytokeratins are of great value for diagnosis. Nasal cavity represents a very unusual location for this type of tumors; soft tissue tumors must be included in the differential diagnosis of nasal obstruction. Due to the possibility of local recurrence, clinical follow-up is recommended.
authors.affiliation: Department of Pathology, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA, 19111, USA. mtuluc@yahoo.com
authors.forename: Madalina
authors.initials: M
authors.lastname: Tuluc
authors.forename: Xinmin
authors.initials: X
authors.lastname: Zhang
authors.forename: Susan
authors.initials: S
authors.lastname: Inniss
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005870:Giant Cell Tumors / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D009296:Nasal Cavity / Q000473:pathology* / Q000601:surgery; D015508:Nasal Obstruction / Q000209:etiology; D009669:Nose Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery