title: "Naked" radiopharmaceuticals.
abstract: The term "naked" radiopharmaceuticals, more appropriately, "unbound" radiopharmaceuticals, refers to any radioisotope used for clinical research or clinical purposes that is not attached to a chemical or biological carrier, and that localizes in various tissues because of a physiologic or chemical propensity/affinity, or secondary to focal anatomic placement. Although they remain useful in selected clinical circumstances, the available agents (except for Iodine-131) have been relegated to an unfortunate and somewhat secondary role. The agents remain useful and worthy of consideration for new clinical investigation and clinical use.
authors.affiliation: 21st Century Oncology Inc., Fort Meyers, FL, USA. pwallner@rtsx.com
authors.forename: Paul E
authors.initials: PE
authors.lastname: Wallner
mesh_terms: D007457:Iodine Radioisotopes / Q000627:therapeutic use; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use; D011868:Radioisotopes / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D012493:Samarium / Q000627:therapeutic use; D013326:Strontium Radioisotopes / Q000627:therapeutic use; D013959:Thyroid Diseases / Q000532:radiotherapy
chemical_list: D007457:Iodine Radioisotopes; D010761:Phosphorus Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D013326:Strontium Radioisotopes; D012493:Samarium