title: Implication of biofilm formation in the persistence of urinary tract infection caused by uropathogenic Escherichia coli.
abstract: Escherichia coli is the most frequent microorganism involved in urinary tract infection (UTI). Acute UTI caused by uropathogenic E. coli (UPEC) can lead to recurrent infection, which can be defined as either re-infection or relapse. E. coli strains causing relapse (n = 27) and re-infection (n = 53) were analysed. In-vitro production of biofilm, yersiniabactin and aerobactin was significantly more frequent among strains causing relapse. Biofilm assays may be helpful in selecting patients who require a therapeutic approach to eradicate persistent biofilm-forming E. coli strains and prevent subsequent relapses.
authors.affiliation: Microbiology Department, Hospital Clinic, Barcelona, Spain.
authors.forename: S M
authors.initials: SM
authors.lastname: Soto
authors.forename: A
authors.initials: A
authors.lastname: Smithson
authors.forename: J P
authors.initials: JP
authors.lastname: Horcajada
authors.forename: J A
authors.initials: JA
authors.lastname: Martinez
authors.forename: J P
authors.initials: JP
authors.lastname: Mensa
authors.forename: J
authors.initials: J
authors.lastname: Vila
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018441:Biofilms; D004926:Escherichia coli / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005260:Female; D006801:Humans; D006877:Hydroxamic Acids / Q000378:metabolism; D008875:Middle Aged; D010636:Phenols / Q000378:metabolism; D013844:Thiazoles / Q000378:metabolism; D014552:Urinary Tract Infections / Q000382:microbiology*; D014774:Virulence
chemical_list: D006877:Hydroxamic Acids; D010636:Phenols; D013844:Thiazoles; C104398:yersiniabactin; C031819:aerobactin