[Malaria vaccines: prospects and reality].
The development of a malaria vaccine has been accelerating in the last ten years. The number of clinical trials has increased and some malaria antigens have been tested in endemic areas. No potential vaccine has yet shown sufficient and lasting efficacy to justify its inclusion in a public health program. However, trials have unambiguously shown that some level of anti-malaria clinical immunity can be achieved by vaccination, both in experimental and in field conditions. Advances in malaria vaccine development are presented.
Rogier
C
C
Unité de recherche en biologie et épidémiologie parasitaires, institut de médecine tropicale du service de santé des armées, Le Pharo, BP 46, 13998 Marseille-Armées, France. christophe.rogier@wanadoo.fr
Orlandi-Pradines
E
E
Fusaï
T
T
Pradines
B
B
Briolant
S
S
Almeras
L
L
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D002986:Clinical Trials as Topic; D006801:Humans; D008288:Malaria / Q000276:immunology*; D017780:Malaria Vaccines; D010961:Plasmodium / Q000276:immunology
D000953:Antigens, Protozoan; D017780:Malaria Vaccines