Proteomics and transfusion medicine: future perspectives.
Limited number of important discoveries have greatly contributed to the progresses achieved in the blood transfusion; ABO histo-blood groups, citrate as anticoagulant, fractionation of plasma proteins, plastic bags and apheresis machines. Three major types of blood products are transfused to patients: red cell concentrates, platelet concentrates and fresh frozen plasma. Several parameters of these products change during storage process and they have been well studied over the years. However, several aspects have completely been ignored; in particular those related to peptide and protein changes. This review presents what has been done using proteomic tools and the potentials of proteomics for transfusion medicine.
Queloz
Pierre-Alain
PA
Service régional vaudois de transfusion sanguine, Lausanne, Switzerland.
Thadikkaran
Lynne
L
Crettaz
David
D
Rossier
Joel S
JS
Barelli
Stefano
S
Tissot
Jean-Daniel
JD
D000017:ABO Blood-Group System; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001781:Blood Component Removal; D001792:Blood Platelets / Q000378:metabolism; D001798:Blood Proteins / Q000737:chemistry; D001803:Blood Transfusion / Q000379:methods*; D019295:Computational Biology / Q000379:methods; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D017713:Platelet Transfusion / Q000379:methods*; D040901:Proteomics / Q000379:methods*
D000017:ABO Blood-Group System; D000925:Anticoagulants; D001798:Blood Proteins