title: Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity.
abstract: Seventy-six plant extracts including methanolic and successive water extracts from 37 Indian medicinal plants were investigated for acetylcholinesterase (AChE) inhibitory activity (in vitro). Results indicated that methanolic extracts to be more active than water extracts. The potent AChE inhibiting methanolic plant extracts included Withania somnifera (root), Semecarpus anacardium (stem bark), Embelia ribes (Root), Tinospora cordifolia (stem), Ficus religiosa (stem bark) and Nardostachys jatamansi (rhizome). The IC(50) values obtained for these extracts were 33.38, 16.74, 23.04, 38.36, 73.69 and 47.21mug/ml, respectively. These results partly substantiate the traditional use of these herbs for improvement of cognition.
authors.affiliation: Department of Pharmacognosy, Al-Ameen College of Pharmacy, Hosur Road, Bangalore, India.
authors.forename: B
authors.initials: B
authors.lastname: Vinutha
authors.forename: D
authors.initials: D
authors.lastname: Prashanth
authors.forename: K
authors.initials: K
authors.lastname: Salma
authors.forename: S L
authors.initials: SL
authors.lastname: Sreeja
authors.forename: D
authors.initials: D
authors.lastname: Pratiti
authors.forename: R
authors.initials: R
authors.lastname: Padmaja
authors.forename: S
authors.initials: S
authors.lastname: Radhika
authors.forename: A
authors.initials: A
authors.lastname: Amit
authors.forename: K
authors.initials: K
authors.lastname: Venkateshwarlu
authors.forename: M
authors.initials: M
authors.lastname: Deepak
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007194:India; D008518:Medicine, East Asian Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase