A convergent and enantioselective synthesis of (+)-amurensinine via selective C-H and C-C bond insertion reactions.
A convergent and enantioselective synthesis of the natural product amurensinine is described. The synthetic strategy takes advantage of mild and selective C-H and C-C bond insertion reactions, in addition to the palladium-catalyzed aerobic oxidative kinetic resolution recently developed in these laboratories.
Tambar
Uttam K
UK
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Ebner
David C
DC
Stoltz
Brian M
BM
D000470:Alkaloids / Q000138:chemical synthesis*; D002384:Catalysis; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000737:chemistry
D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C521894:amurensinine; D010165:Palladium