title: Local recurrence and distant metastasis of supratentorial primitive neuro-ectodermal tumor in an adult patient successfully treated with intensive induction chemotherapy and maintenance temozolomide.
abstract: Supratentorial primitive neuro-ectodermal tumors (PNET) in adults are very rare. Extraneural metastasis are unusual and the optimal palliative chemotherapy regimen is not established. We present a 26-year-old patient with local recurrence and distant metastasis of supratentorial PNET successfully treated with intensive induction chemotherapy and maintenance temozolomide.
authors.affiliation: Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands. frederiek.joris@12move.nl
authors.forename: F
authors.initials: F
authors.lastname: Terheggen
authors.forename: D
authors.initials: D
authors.lastname: Troost
authors.forename: C B
authors.initials: CB
authors.lastname: Majoie
authors.forename: S
authors.initials: S
authors.lastname: Leenstra
authors.forename: D J
authors.initials: DJ
authors.lastname: Richel
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D019046:Bone Marrow Neoplasms / Q000188:drug therapy / Q000556:secondary*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000601:surgery; D018242:Neuroectodermal Tumors, Primitive / Q000188:drug therapy / Q000556:secondary*; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D015173:Supratentorial Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000077204:Temozolomide; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D000077204:Temozolomide; D008727:Methotrexate