title: Mechanisms of injury to the newborn brain.
abstract: Preterm and ill term infants are at risk for brain injury and subsequent neurodevelopmental delay as a result of many perinatal factors. Outlined in this article are the basic science mechanisms by which hypoxia, hypocapnia, and hypercapnia may result in neuronal injury in the newborn brain.
authors.affiliation: Department of Pediatrics, Division of Neonatology, St. Christopher's Hospital for Children, Front and Erie Streets, Philadelphia, PA 19134, USA. Karen.Fritz@drexelmed.edu
authors.forename: Karen I
authors.initials: KI
authors.lastname: Fritz
authors.forename: Maria
authors.initials: M
authors.lastname: Delivoria-Papadopoulos
mesh_terms: D001927:Brain Diseases / Q000209:etiology* / Q000503:physiopathology; D020013:Calcium Signaling / Q000502:physiology; D053938:DNA Fragmentation / Q000502:physiology; D006801:Humans; D006935:Hypercapnia / Q000150:complications / Q000503:physiopathology; D016857:Hypocapnia / Q000150:complications / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000150:complications / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology* / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents