title: The role of heat shock proteins as chaperones on several human diseases.
abstract: Some heat shock proteins HSPs, act as molecular chaperones. These and other molecular chaperones that are not HSPs, function in a variety of protein biosynthetic event and protect proteins from the deleterious effects of stressors by stabilizing, and refolding proteins. They assist protein folding, assembly, transport and degradation. Several human diseases such as neurodegeneration, cancer, aging, retinal dystrophy, and inflammation arise from defects HSPs and protein folding. This review demonstrates the chaperones such as properties of HSPs in cellular processes and their implication in different kind of human diseases.
authors.affiliation: Department of Biochemistry, Zanjan University of Medical Sciences, Shahrak Karmandan, Zanjan, Iran. mellati3000@yahoo.com
authors.forename: Ali A
authors.initials: AA
authors.lastname: Mellati
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism; D017510:Protein Folding; D012164:Retinal Diseases / Q000378:metabolism
chemical_list: D006360:Heat-Shock Proteins; D018832:Molecular Chaperones