DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.
We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).
Voso
Maria Teresa
MT
Istituti di Ematologia, Universita' Cattolica Sacro Cuore, Rome. mtvoso@rm.unicatt
Gumiero
Daniela
D
D'Alo'
Francesco
F
Guidi
Francesco
F
Mansueto
Giovanna
G
Di Febo
Anna Laura
AL
Massini
Giuseppina
G
Martini
Maurizio
M
Larocca
Luigi Maria
LM
Hohaus
Stefan
S
Leone
Giuseppe
G
D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000032:analysis / Q000235:genetics*; D014408:Biomarkers, Tumor; D001853:Bone Marrow / Q000201:enzymology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000032:analysis / Q000235:genetics*; D019175:DNA Methylation; D064550:Death-Associated Protein Kinases; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome
D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases