title: Power spectral analysis of two-channel EEG in hypoxic-ischaemic encephalopathy.
abstract: OBJECTIVE
  Power spectral analysis combined with a two-channel EEG system may be useful in management of newborn term infants at risk of hypoxic-ischaemic encephalopathy (HIE). This pilot study aimed to determine differences in the EEG power spectrum between normal term infants, infants who were at risk of but had not developed HIE, and infants who had developed HIE.
  
  
  METHODS
  Observational.
  
  
  METHODS
  EEG recordings from normal term newborn infants and term infants at risk of HIE were analyzed using fast Fourier transforms. EEG total power (TP), TP variance, TP coefficient of variation (TP CV) and spectral edge frequency (SEF) were compared between three groups: control infants (n=15); at-risk infants who had not developed clinically diagnosed HIE (n=4); and at-risk infants who had developed HIE (n=7).
  
  
  RESULTS
  Total power was similar in all groups. Variation of TP (variance and CV) was higher (p<0.05) in control infants than in infants at risk of HIE, regardless of whether they had developed HIE. SEF values were similar across all three groups.
  
  
  CONCLUSIONS
  Reduced variation of EEG power is a feature of infants at risk of HIE.
authors.affiliation: Ritchie Centre for Baby Health Research, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia. Flora.Wong@med.monash.edu.au
authors.forename: Flora Y
authors.initials: FY
authors.lastname: Wong
authors.forename: Charles P
authors.initials: CP
authors.lastname: Barfield
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Walker
mesh_terms: D000704:Analysis of Variance; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis*; D007231:Infant, Newborn; D012890:Sleep / Q000502:physiology; D013057:Spectrum Analysis / Q000379:methods*