Novel intragenotype recombination in sapovirus.
Based on the genetic analysis, a novel, naturally occurring recombination between two distinct sapovirus subtypes (subtype a and subtype b) within genogroup I genotype 1 was identified. Breakpoint analysis of recombinant sapovirus showed that the recombination site was at the polymerase-capsid junction. This is the first report of the existence of acute gastroenteritis caused by intragenotype recombinant sapovirus. The results also provided evidence that the natural recombination occurs not only in sapovirus genogroup II but also in sapovirus genogroup I.
Phan
Tung Gia
TG
Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yan
Hainian
H
Khamrin
Pattara
P
Quang
Trinh Duy
TD
Dey
Shuvra Kanti
SK
Yagyu
Fumihiro
F
Okitsu
Shoko
S
Müller
Werner E G
WE
Ushijima
Hiroshi
H
D001483:Base Sequence; D005759:Gastroenteritis / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic / Q000235:genetics*; D029341:Sapovirus / Q000145:classification / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D013045:Species Specificity