title: [Lysophosphatidic acid in ovarian cancer patients].
abstract: OBJECTIVE
  To compare plasma lysophosphatidic acid (LPA) level in ovarian cancer patients and women without ovarian pathology.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Department of Gynecology and Obstetrics, University Hospital, Hradec Králové.
  
  
  METHODS
  The method for LPA level analyze with its specification by capillary electrophoresis using indirect ultraviolet detection has been implementated. Since the beginning of this project venous blood samples from 103 patients (60 patients with ovarian cancer, 43 patients without ovarian pathology) have been obtained.
  
  
  RESULTS
  Plasma LPA levels were elevated in ovarian cancer patients (sigma LPA Med 19.9 micromol/l, Range 4.5-42.7 micromol/l). Patients without ovarian pathology (n=35) (sigma LPA Med 2.6 micromol/l, Range 0.9-22.9 micromol/l, P<0,001) had statistically significant lower plasma LPA level compared with ovarian cancer patients.
  
  
  CONCLUSIONS
  Lysophosphatidic acid appears useful as diagnostic marker of ovarian cancer.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital, Hradec Králové.
authors.forename: I
authors.initials: I
authors.lastname: Sedlákova
authors.forename: J
authors.initials: J
authors.lastname: Vávrová
authors.forename: J
authors.initials: J
authors.lastname: Tosner
authors.forename: L
authors.initials: L
authors.lastname: Hanousek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008246:Lysophospholipids / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D008246:Lysophospholipids; C032881:lysophosphatidic acid