title: Efficacy of an essential oil of Eugenia caryophyllata against Psoroptes cuniculi.
abstract: The acaricidal activity of Eugenia caryophyllata essential oil was evaluated in vitro and in vivo on Psoroptes cuniculi, a mange mite. In vitro, different concentrations of the oil were tested and the observed mites mortality was compared with that observed in untreated and treated (Acacerulen R) controls. In vivo, six P. cuniculi infected rabbits were topically treated with the oil diluted at 2.5% and compared with untreated and treated control groups of six rabbits each. In vitro, up to the concentration of 0.10% the oil gave highly significant (P<0.01) percentages of mite mortality respect to the untreated controls, but only up to 0.16% it showed the same efficacy of Acacerulen R. In vivo, the treatment with the essential oil cured all infested rabbits and no statistical differences were observed respect to the treated control group. The untreated rabbits remained infested.
authors.affiliation: Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, Faculty of Veterinary Medicine, University of Pisa, Viale delle Piagge 2, 56124 Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fichi
authors.forename: G
authors.initials: G
authors.lastname: Flamini
authors.forename: F
authors.initials: F
authors.lastname: Giovanelli
authors.forename: D
authors.initials: D
authors.lastname: Otranto
authors.forename: S
authors.initials: S
authors.lastname: Perrucci
mesh_terms: D000287:Administration, Topical; D000818:Animals; D045783:Clove Oil / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004431:Ear, External / Q000469:parasitology; D005054:Eugenol / Q000032:analysis; D005260:Female; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy*; D000081223:Polycyclic Sesquiterpenes; D040042:Psoroptidae / Q000187:drug effects*; D011817:Rabbits; D012717:Sesquiterpenes / Q000032:analysis; D027842:Syzygium / Q000737:chemistry*
chemical_list: D045783:Clove Oil; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D005054:Eugenol; C024714:caryophyllene