title: Ameliorating role of caffeic acid phenethyl ester (CAPE) against isoniazid-induced oxidative damage in red blood cells.
abstract: Isoniazid (INH) still remains a first-line drug both for treatment and prophylaxis of tuberculosis, but various organs toxicity frequently develops in patients receiving this drug. We aimed to investigate possible toxic effects of INH on rat red blood cells (RBCs), and to elucidate whether Caffeic acid phenethyl ester (CAPE) prevents a possible toxic effect of INH. Experimental groups were designed as follows: control group, INH group, INH + CAPE group. Compared with the control, the INH caused a significant increase in superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels, and a decrease in glutathione peroxidase (GSH-Px) and catalase (CAT), which are recently used to monitor the development and extent of damage due to oxidative stresses. CAPE administration to INH group ameliorated above changes due to INH.
authors.affiliation: Faculty of Medicine, Department of Pharmacology, Suleyman Demirel University, Isparta, Turkey. ogokalp@med.sdu.edu.tr
authors.forename: Osman
authors.initials: O
authors.lastname: Gokalp
authors.forename: Efkan
authors.initials: E
authors.lastname: Uz
authors.forename: Ekrem
authors.initials: E
authors.lastname: Cicek
authors.forename: H Ramazan
authors.initials: HR
authors.lastname: Yilmaz
authors.forename: Mehmet Kaya
authors.initials: MK
authors.lastname: Ozer
authors.forename: Ayse
authors.initials: A
authors.lastname: Altunbas
authors.forename: Nurten
authors.initials: N
authors.lastname: Ozcelik
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000633:toxicity; D002109:Caffeic Acids / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology; D007538:Isoniazid / Q000633:toxicity*; D008297:Male; D018384:Oxidative Stress; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; D007538:Isoniazid