Oxidative Mannich reaction of N-carbobenzyloxy amines with 1,3-dicarbonyl compounds.
Efficient carbon-carbon bond formation at the alpha-position of nitrogen was established by one-pot oxidative Mannich reaction of N-carbobenzyloxy (Cbz) amines with 1,3-dicarbonyl compounds using N-tert-butylbenzenesulfinimidoyl chloride as an oxidant.
Matsuo
Jun-ichi
J
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. jimatsuo@p.kanazawa-u.ac.jp
Tanaki
Yumi
Y
Ishibashi
Hiroyuki
H
D000588:Amines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D010084:Oxidation-Reduction
D000588:Amines; D007659:Ketones