title: Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients.
abstract: The aim of this study was to investigate whether insulin resistance is independently associated with early manifestations of atherosclerosis. To this end, 176 normotensive offspring of type 2 diabetic patients were subjected to euglycemic hyperinsulinemic clamp to assess insulin sensitivity. Early atherosclerosis was studied by ultrasonography of the common carotid artery. Of the total 176 subjects, 145 were glucose tolerant, 18 had impaired fasting glucose, and 13 had impaired glucose tolerance. Univariate correlations showed that age, body mass index, waist, blood pressure, 2-h postchallenge glucose, fasting insulin, triglycerides, interleukin-6, fibrinogen, and white blood cell count were significantly correlated with carotid intima-media thickness (IMT), whereas HDL cholesterol and glucose disposal showed a negative correlation. A stepwise multivariate regression analysis including sex, age, waist circumference, smoking status, systolic blood pressure, diastolic blood pressure, triglyceride, HDL cholesterol, 2-h postchallenge glucose, plasma IL-6, fibrinogen, white blood cell count, insulin-stimulated glucose disposal, and fasting insulin showed that the four variables that remained significantly associated with carotid IMT were waist circumference, insulin-stimulated glucose disposal, white blood cell count, and diastolic blood pressure, accounting for 33.7% of its variation. These findings support the concept that insulin sensitivity, rather than plasma insulin levels, is associated with early atherosclerosis in nondiabetic normotensive offspring of type 2 diabetic patients.
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Policlinico Universitario Mater Domini, Via Europa, Campus Germaneto, 88100 - Catanzaro, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Cardellini
authors.forename: Maria Adelaide
authors.initials: MA
authors.lastname: Marini
authors.forename: Simona
authors.initials: S
authors.lastname: Frontoni
authors.forename: Marta Letizia
authors.initials: ML
authors.lastname: Hribal
authors.forename: Francesco
authors.initials: F
authors.lastname: Andreozzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Perticone
authors.forename: Massimo
authors.initials: M
authors.lastname: Federici
authors.forename: Davide
authors.initials: D
authors.lastname: Lauro
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sesti
mesh_terms: D000328:Adult; D032721:Adult Children; D050197:Atherosclerosis / Q000473:pathology; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D017536:Carotid Artery, Common / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology; D003925:Diabetic Angiopathies / Q000473:pathology; D005260:Female; D005947:Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood / Q000502:physiology*; D007333:Insulin Resistance; D008297:Male; D008660:Metabolism; D008875:Middle Aged; D017540:Tunica Media / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose