title: Successful treatment of disseminated mucormycosis with a combination of liposomal amphotericin B and posaconazole in a patient with acute myeloid leukaemia.
abstract: The combination of resection of infected tissue and antifungal therapy is the treatment of choice in mucormycosis. In disseminated mucormycosis, where surgery is impossible, the mortality is almost 90%. We report the first case of disseminated mucormycosis that was cured with a combination therapy of liposomal amphotericin B and posaconazole without surgical intervention.
authors.affiliation: Medizinische Klinik II, Klinikum der J.W. Goethe Universitaet, Frankfurt, Germany. rickerts@em.uni-frankfurt.de
authors.forename: V
authors.initials: V
authors.lastname: Rickerts
authors.forename: J
authors.initials: J
authors.lastname: Atta
authors.forename: S
authors.initials: S
authors.lastname: Herrmann
authors.forename: V
authors.initials: V
authors.lastname: Jacobi
authors.forename: E
authors.initials: E
authors.lastname: Lambrecht
authors.forename: R
authors.initials: R
authors.lastname: Bialek
authors.forename: G
authors.initials: G
authors.lastname: Just-Nübling
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008081:Liposomes / Q000627:therapeutic use*; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy*; D020103:Rhizomucor / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B