title: Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors.
abstract: The synthesis of several cyclen based lanthanide [Eu(III) and La(III)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP (an RNA model compound) that is highly dependent on the length of the alkyl spacer.
authors.affiliation: School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Fanning
authors.forename: Sally E
authors.initials: SE
authors.lastname: Plush
authors.forename: Thorfinnur
authors.initials: T
authors.lastname: Gunnlaugsson
mesh_terms: D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008956:Models, Chemical; D010755:Organophosphates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012333:RNA, Messenger / Q000737:chemistry*
chemical_list: C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D000080027:Cyclams; D006571:Heterocyclic Compounds; D028581:Lanthanoid Series Elements; D010755:Organophosphates; D009943:Organophosphorus Compounds; D012333:RNA, Messenger; C038072:cyclen