Carvedilol prevents myocardial fibrosis in hamsters.
The objective of the present study was to determine if carvedilol protects against myocardial degeneration and fibrotic change, and reduces mortality in TO2 hamsters. Carvedilol was administered intraperitoneally to 8 week-old TO2 hamsters for 21 weeks at a dose of 11 mg/kg/day. There were 15 TO2 hamsters in the carvedilol group (group C) and 10 in the untreated group (group N). The control group consisted of 11 Fb hamsters (group F). The mortality rate was determined from the number of surviving hamsters after 29 weeks. Myocardial fibrosis was evaluated by MRI and histopathological examination. EF and LVDd were determined by echocardiography at 8 and 29 weeks, while the MRI score was calculated at 29 weeks. Mortality, histopathological fibrosis, and MRI score were all lower in group C than in group N. Carvedilol had a protective effect against myocardial fibrosis and decreased the mortality rate in TO2 hamsters.
Nanjo
Shuji
S
Division of Cardiovascular Medicine, Department of Internal Medicine, Ohmori Hospital, Toho University School of Medicine, Tokyo, Japan.
Yamazaki
Junichi
J
Yoshikawa
Kohki
K
Ishii
Toshiharu
T
Togane
Yuko
Y
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D000077261:Carvedilol; D006224:Cricetinae; D004195:Disease Models, Animal; D004452:Echocardiography; D005355:Fibrosis / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D006331:Heart Diseases / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D009206:Myocardium / Q000473:pathology*; D011412:Propanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D015996:Survival Rate; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol