Effect of vitamin E on monosodium glutamate induced hepatotoxicity and oxidative stress in rats.
Monosodium glutamate (MSG), administered to rats (by gavage) at a dose of 0.6 mg/g body weight for 10 days, significantly (P<0.05) induced lipid peroxidation (LPO), decreased reduced glutathione (GSH) level and increased the activities of glutathione-s-transferase (GST), catalase and superoxide dismutase (SOD) in the liver of the animals; these were observed 24 hr after 10 days of administration. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT) were also significantly increased in the serum, on MSG administration. Vitamin E (0.2 mg/g body wt) co-administered with MSG, significantly reduced the LPO, increased the GSH level and decreased the hepatic activities of GST, catalase and SOD. The activities of ALT, AST and GGT in the serum were also significantly reduced. The results showed that MSG at a dose of 0.6 mg/g body wt induced the oxidative stress and hepatotoxicity in rats and vitamin E ameliorated MSG-induced oxidative stress and hepatotoxicity.
Onyema
Oscar Okwudiri
OO
Toxicology Unit, Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria. oscarow@yahoo.co.uk
Farombi
Ebenezer Olatunde
EO
Emerole
Godwin O
GO
Ukoha
Agwu Igwe
AI
Onyeze
Godffrey Okeke
GO
D000818:Animals; D008099:Liver / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000633:toxicity*; D014810:Vitamin E / Q000502:physiology*
D014810:Vitamin E; D012970:Sodium Glutamate