Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases.
Geographical widespread data on human papillomavirus (HPV) type-distribution are essential for estimating the impact of HPV-16/18 vaccines on cervical cancer and cervical screening programmes. Epidemiological studies employing a variety of HPV typing protocols have been collated in meta-analyses. HPV-16/18 is estimated to account for 70% of all cervical cancers worldwide, although the estimated HPV-16/18 fraction is slightly higher in more developed (72-77%) than in less developed (65-72%) regions. About 41-67% of high-grade squamous intraepithelial lesion (HSIL), 16-32% of low-grade squamous intraepithelial lesion (LSIL) and 6-27% of atypical squamous cells of undetermined significance (ASCUS) are also estimated to be HPV-16/18-positive, thus highlighting the increasing relative frequency of HPV-16/18 with increasing lesion severity. After HPV-16/18, the six most common HPV types are the same in all world regions, namely 31, 33, 35, 45, 52 and 58; these account for an additional 20% of cervical cancers worldwide.
Clifford
Gary
G
International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon cedex 08, France. clifford@iarc.fr
Franceschi
Silvia
S
Diaz
Mireia
M
Muñoz
Nubia
N
Villa
Luisa Lina
LL
D005260:Female; D006801:Humans; D017720:Molecular Epidemiology; D009369:Neoplasms / Q000453:epidemiology / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification* / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence