[The nitric oxide metabolites in women with hypertension in pregnancy].
OBJECTIVE
Hypertension occurs in 5 to 10 % of pregnancies. As the result we can observe the increased percentage of preterm deliveries and cesarean sections. Hypertension is well-known reason of intrauterine growth restriction. The decrease of nitric oxide metabolites production may be connected to endothelial cells deficiency. It depends on NO deficiency and lipid peroxidation processes. The concentration of NO metabolites measured in pregnancy can show the correlation between oxidative stress and NO metabolism. High risk of destruction biological function of cells by free radical processes is observed in hypertension


METHODS
The aim of the study was to find correlation between the nitric oxide metabolites such nitrites in healthy pregnant women and in hypertensive pregnancies.


METHODS
The study was taken in Medical University in Lodz in 2002-2005. The study group consisted of 35 women with hypertension in pregnancy, the control group consisted of 30 healthy women. The nitrite activity was measured by Oxis kit and was expressed in micromol/l.


RESULTS
In group of hypertensive pregnancies lower concentration of NO metabolites was observed if compared to the control group.


CONCLUSIONS
We found the difference between two groups and the decrease of NO metabolites concentration in hypertensive pregnancy.
Karowicz-Bilińska
Agata
A
Klinika Patologii Ciazy I Katedry Połoznictwa i Ginekologii Uniwersytetu Medycznego w Lodzi. agakar@interia.pl
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D011247:Pregnancy; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016387:Women's Health
D008054:Lipid Peroxides; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase