[Oxidative stress and inflammation with angiographic morphology of coronary lesions in patients with coronary heart disease].
OBJECTIVE
To evaluate the role of oxidative stress and inflammation in the development of plaque rupture.


METHODS
One hundred and ten patients enrolled in this study. All patients underwent coronary angiography. It included 85 patients with coronary heart disease (CHD) and 25 controls. The angiographic morphology of plaques was analyzed. According to the morphologic types of plaque, CHD patients were divided into Type I (smooth borders) group (n=31), Type II (irregular lesions) group (n=35), and Type III (long lesions) group (n=19). All patients were measured of MDA-LDL, hs-CRP, creatine kinase (CK), and MB isoenzyme of CK (CK-MB) in the plasma.


RESULTS
Plasma MDA-LDL and hs-CRP in the Type II group were significantly higher than those in the control group, Type I group, and Type III group (P<0.01). The plasma levels of MDA-LDL were not correlated to LDL and HDL in patients in Type II group (P>0.05). The plasma levels of MDA-LDL and hs-CRP had a significant positive correlation in patients in Type II group (r=0.630, P<0.01).


CONCLUSIONS
Oxidative stress and inflammation may cause plaque rupture in CHD patients. The oxidative stress is likely to either induce or intensify the inflammatory action, and may co-affect with inflammation factors to cause or accelerate plaque rupture.
Zhang
Zhi-hui
ZH
Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China. zzhaihf@126.com
Zhou
Sheng-hua
SH
Qi
Shu-shan
SS
Li
Xu-ping
XP
D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D006801:Humans; D007249:Inflammation; D018836:Inflammation Mediators / Q000097:blood; D018384:Oxidative Stress
D018836:Inflammation Mediators