title: Long-term, health-related, quality of life comparison in patients undergoing single stage vs staged resection for complicated diverticular disease.
abstract: OBJECTIVE
  To evaluate long-term health-related quality of life, for single-staged and staged resections following reversal, for complicated diverticular disease.
  
  
  METHODS
  Between 1981 and 2003, 188 patients undergoing single stage (n = 158) or staged resection (n = 30) completed the SF-36 questionnaire. Health-related quality of life (HRQL) was compared between the two groups and the US normal population based on the eight domains of the SF-36. HRQL analysis was also performed at various time intervals. The effect of age and postoperative complications on HRQL was also determined. Functional and postoperative outcomes were also assessed.
  
  
  RESULTS
  The single and staged resection groups differed in the presence of comorbidity, degree of peritoneal contamination and operative urgency. No difference in functional outcomes or HRQL was found, even after analysing time-interval subgroups. Social functioning and general health was substantially worse in both groups when compared to US norms. Ageing was found to significantly reduce physical functioning (P < 0.001) and physical and emotional role limitations (P < 0.001 for both). Post-operative complications significantly reduced scores when compared to patients without complications, for physical functioning (63.57 vs 78.7, respectively; P < 0.001), physical role limitation (80.65 vs 86.9, respectively; P < 0.001) and bodily pain (66.67 vs 74.81, respectively; P < 0.01).
  
  
  CONCLUSIONS
  No significant difference in long-term HRQL was found in patients undergoing single staged or staged resection for complicated diverticular disease. There was significant impact of ageing and postoperative complications on physical health. Prospective studies that include pre-operative data on HRQL are required to compare the two operative techniques, with emphasis on quality of life of patients left with a permanent stoma.
authors.affiliation: Imperial College London, Department of Surgical Oncology and Technology, St Mary's Hospital, London, United Kingdom.
authors.forename: V A
authors.initials: VA
authors.lastname: Constantinides
authors.forename: H N
authors.initials: HN
authors.lastname: Aydin
authors.forename: P P
authors.initials: PP
authors.lastname: Tekkis
authors.forename: V W
authors.initials: VW
authors.lastname: Fazio
authors.forename: A G
authors.initials: AG
authors.lastname: Heriot
authors.forename: F H
authors.initials: FH
authors.lastname: Remzi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000379:methods; D013505:Digestive System Surgical Procedures / Q000379:methods; D043963:Diverticulosis, Colonic / Q000601:surgery*; D004241:Diverticulum, Colon / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009820:Ohio; D011183:Postoperative Complications; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome