title: Unusual presentation of tuberculosis as a splenic mass.
abstract: Tuberculosis is an important health problem in developing countries, with varying clinical presentations depending on the organs/systems involved. Tuberculosis is mostly seen in immuno-compromised individuals, such as those with acquired immune deficiency syndrome or malignancies. Here we report a case of a spleen tuberculoma in a 29-year-old male patient with no known immune deficiency. He first presented with abdominal pain, and subsequent ultrasonographic examination revealed a splenic lesion of 10 cm in diameter. A computerized tomography scan of the abdomen confirmed the presence of a solitary, hypodense, septated cystic lesion. Lack of evidence supporting the presence of a splenic infection or a primary/metastatic malignancy prompted explorative surgery where a septated abscess formation was discovered and splenectomy was performed. Histopathological examination revealed granulomatous inflammatory changes with Langerhans-type giant cells, which are consistent with tuberculosis. For a period of two months, antituberculosis therapy with four drugs, isoniazid, rifampicin, pyrazinamide, and ethambutol, was carried out. Pyrazinamide and ethambutol were quitted at the end of two months. Therapy with isoniazid and rifampicin was planned for an additional 10 months. We would like to call attention to yet another atypical presentation of extrapulmonary tuberculosis.
authors.affiliation: Department of Internal Medicine, Ankara Numune Research and Education Hospital, Turkey. fatded@yahoo.com
authors.forename: Fatih
authors.initials: F
authors.lastname: Dede
authors.forename: Elvin
authors.initials: E
authors.lastname: Doğan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Demir
authors.forename: Didem
authors.initials: D
authors.lastname: Sener
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kös
authors.forename: Murat
authors.initials: M
authors.lastname: Tad
authors.forename: Erdal
authors.initials: E
authors.lastname: Eskioğlu
mesh_terms: D000328:Adult; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D012293:Rifampin / Q000627:therapeutic use; D013154:Spleen / Q000187:drug effects / Q000473:pathology*; D013156:Splenectomy; D014057:Tomography, X-Ray Computed; D014374:Tuberculin Test; D014400:Tuberculosis, Splenic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000904:Antibiotics, Antitubercular; D007538:Isoniazid; D012293:Rifampin