title: Injection of prostaglandin F2alpha into the bronchial artery in sheep increases the pulmonary vascular permeability to protein.
abstract: Lung injury and oedema following smoke inhalation are associated with eicosanoid release and the injury is heavily influenced by the tracheobronchial circulation. We hypothesized that injection of a vasoactive eicosanoid, prostaglandin F2alpha (PGF2alpha), into the tracheobronchial circulation would induce a permeability leak in that circulation as measured in lung lymph flow and protein content. PGF2alpha when injected into the bronchial artery increased lung lymph flow, protein content and lymph protein flux (protein times flow). The increase in lymph to plasma protein concentration after injection of PGF2alpha is consistent with an increase in vascular protein permeability since an increase in pressure alone would cause an increase in fluid flow in excess of protein with a fall in protein concentration. Ligation of the bronchial artery 3min after injection of the PGF2alpha largely prevented the late changes suggesting that the protein leak into the lymph was from the bronchial arteries.
authors.affiliation: Pulmonary and Critical Care Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 148, Boston, MA 02114-2696, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Efimova
authors.forename: Alexei
authors.initials: A
authors.lastname: Volokhov
authors.forename: Charles A
authors.initials: CA
authors.lastname: Hales
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D001980:Bronchi / Q000098:blood supply; D001981:Bronchial Arteries / Q000187:drug effects* / Q000502:physiology; D002199:Capillary Permeability / Q000187:drug effects*; D015237:Dinoprost / Q000008:administration & dosage / Q000494:pharmacology*; D007269:Injections, Intra-Arterial; D008168:Lung / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D012756:Sheep; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D015237:Dinoprost