title: Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly.
abstract: The response regulator CovR acts as a master regulator of virulence in Streptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.
authors.affiliation: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Samantha A
authors.initials: SA
authors.lastname: Roberts
authors.forename: Gordon G
authors.initials: GG
authors.lastname: Churchward
authors.forename: June R
authors.initials: JR
authors.lastname: Scott
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D001483:Base Sequence; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D011485:Protein Binding; D012097:Repressor Proteins / Q000378:metabolism*; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; C432143:CsrR protein, Streptococcus pyogenes; D012097:Repressor Proteins