Part 2: building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. Modular solution- and solid-phase approaches for use in high-throughput generation of chemical probes.
The solution- and solid-phase synthesis to obtain several natural-product-like, tetrahydroquinoline-based, polycyclic derivatives were developed. In one approach, two derivatives (38 and 41) having an eight-membered unsaturated lactam were successfully obtained both in solution and on solid support.
Sharma
Utpal
U
Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada, K1A 0R6.
Srivastava
Stuti
S
Prakesch
Michael
M
Sharma
Maya
M
Leek
Donald M
DM
Arya
Prabhat
P
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D000634:Aminoquinolines / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D000634:Aminoquinolines; D015335:Molecular Probes; D011083:Polycyclic Compounds; D012996:Solutions