title: Further evaluation of the synthetic peptide vaccine S3Pvac against Taenia solium cysticercosis in pigs in an endemic town of Mexico.
abstract: Taenia solium cysticercosis is a parasitic disease frequently affecting human health and the pig industry in many developing countries. A synthetic peptide vaccine (designated S3Pvac) against porcine cysticercosis has been developed previously as an aid to interrupt transmission and has been shown to be effective. The results of the present study support the effectiveness of the vaccine under endemic field conditions. However, given the time-frame of the vaccination trial, no changes in the local levels of transmission were detectable before and after vaccination using sentinel pigs. Thus, this investigation shows the limited usefulness of single vaccination as the sole means of interrupting Taenia solium transmission in an endemic region.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, DF México. edda@servidor.unam.mx
authors.forename: E
authors.initials: E
authors.lastname: Sciutto
authors.forename: J
authors.initials: J
authors.lastname: Morales
authors.forename: J J
authors.initials: JJ
authors.lastname: Martínez
authors.forename: A
authors.initials: A
authors.lastname: Toledo
authors.forename: M N
authors.initials: MN
authors.lastname: Villalobos
authors.forename: C
authors.initials: C
authors.lastname: Cruz-Revilla
authors.forename: G
authors.initials: G
authors.lastname: Meneses
authors.forename: M
authors.initials: M
authors.lastname: Hernández
authors.forename: A
authors.initials: A
authors.lastname: Díaz
authors.forename: L F
authors.initials: LF
authors.lastname: Rodarte
authors.forename: G
authors.initials: G
authors.lastname: Acero
authors.forename: G
authors.initials: G
authors.lastname: Gevorkian
authors.forename: K
authors.initials: K
authors.lastname: Manoutcharian
authors.forename: J
authors.initials: J
authors.lastname: Paniagua
authors.forename: G
authors.initials: G
authors.lastname: Fragoso
authors.forename: A
authors.initials: A
authors.lastname: Fleury
authors.forename: R
authors.initials: R
authors.lastname: Larralde
authors.forename: A S
authors.initials: AS
authors.lastname: De Aluja
authors.forename: C
authors.initials: C
authors.lastname: Larralde
mesh_terms: D000818:Animals; D003551:Cysticercosis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D019353:Endemic Diseases / Q000662:veterinary; D005260:Female; D008297:Male; D008800:Mexico / Q000453:epidemiology; D018571:Sentinel Surveillance; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*; D022223:Vaccines, Subunit / Q000276:immunology*
chemical_list: D022223:Vaccines, Subunit