title: Chapter 4: Burden and management of non-cancerous HPV-related conditions: HPV-6/11 disease.
abstract: Human Papillomavirus (HPV)-6 and -11 are the causative agents of ano-genital warts (GWs) and recurrent respiratory papillomatosis (RRP). They are low-risk HPV types that are uncommonly found in malignant lesions. GWs are an extremely prevalent sexually transmitted disease, whereas RRP is a rare disease that can be life threatening and requires multiple surgical procedures. GWs and RRP cause substantial healthcare costs. A quadrivalent HPV-6/11/16/18 vaccine (Merck/SPMSD) has shown essentially 100% protection against GWs in women in early studies. Cost-effectiveness analyses are needed to assess the benefits of the HPV-6/11 virus-like particle (VLP) components of the quadrivalent vaccine in population-based vaccination programmes.
authors.affiliation: Hull York Medical School, University of York, Heslington, York, UK. charles.lacey@hyms.ac.uk
authors.forename: Charles J N
authors.initials: CJ
authors.lastname: Lacey
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Lowndes
authors.forename: Keerti V
authors.initials: KV
authors.lastname: Shah
mesh_terms: D003218:Condylomata Acuminata / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy / Q000821:virology; D052140:Human papillomavirus 11 / Q000302:isolation & purification*; D052163:Human papillomavirus 6 / Q000302:isolation & purification*; D006801:Humans; D010212:Papilloma / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy / Q000821:virology; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy / Q000821:virology; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy / Q000821:virology