Ichthyophonus-induced cardiac damage: a mechanism for reduced swimming stamina in salmonids.
Swimming stamina, measured as time-to-fatigue, was reduced by approximately two-thirds in rainbow trout experimentally infected with Ichthyophonus. Intensity of Ichthyophonus infection was most severe in cardiac muscle but multiple organs were infected to a lesser extent. The mean heart weight of infected fish was 40% greater than that of uninfected fish, the result of parasite biomass, infiltration of immune cells and fibrotic (granuloma) tissue surrounding the parasite. Diminished swimming stamina is hypothesized to be due to cardiac failure resulting from the combination of parasite-damaged heart muscle and low myocardial oxygen supply during sustained aerobic exercise. Loss of stamina in Ichthyophonus-infected salmonids could explain the poor performance previously reported for wild Chinook and sockeye salmon stocks during their spawning migration.
Kocan
R
R
School of Aquatic and Fishery Sciences, University of Washington, Seattle, WA 98358, USA. kocan@u.washington.edu
Lapatra
S
S
Gregg
J
J
Winton
J
J
Hershberger
P
P
D000284:Administration, Oral; D000818:Animals; D049628:Body Size / Q000502:physiology; D005260:Female; D005393:Fish Diseases / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D050298:Mesomycetozoea / Q000472:pathogenicity*; D050738:Mesomycetozoea Infections / Q000503:physiopathology*; D017686:Oncorhynchus mykiss; D010805:Physical Conditioning, Animal / Q000502:physiology; D013047:Specific Pathogen-Free Organisms; D013550:Swimming / Q000502:physiology; D013997:Time Factors