[Mechanism of the buccal permeability of insulin].
Summary of theoretical and experimental data of insulin buccal permeability is presented in the article. The hypothetical mechanism of insulin buccal permeability which complies with published experimental data is proposed. The basic barriers for insulin before getting into blood through the mucous membrane of mouth are indicated and described. On the basis of the proposed hypothetical mechanism the application of surfactants for facilitating the buccal permeability of insulin is substantiated. The proposed mechanism will be useful for the development of new protein buccal preparations.
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D001692:Biological Transport; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008833:Microcirculation / Q000378:metabolism; D009061:Mouth Mucosa / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D013501:Surface-Active Agents / Q000494:pharmacology
D007328:Insulin; D013501:Surface-Active Agents