[A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient].
A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/microl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.
Kubota
Daisuke
D
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University.
Takishima
Chizuru
C
Ishii
Ken-ichi
K
Kawamura
Takahiro
T
Matsumoto
Tomoko
T
Itsui
Yasuhiro
Y
Okada
Eriko
E
Chin
Seishin
S
Oooka
Shinya
S
Tsuchiya
Kiichiro
K
Araki
Akihiro
A
Sakamoto
Naoya
N
Miyata
Tatsuya
T
Kanai
Takanori
T
Watanabe
Mamoru
M
D000038:Abscess / Q000209:etiology; D000328:Adult; D001004:Anus Diseases / Q000209:etiology; D001853:Bone Marrow / Q000187:drug effects*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007079:Ileitis / Q000209:etiology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007958:Leukocyte Count; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects*; D019804:Mesalamine / Q000008:administration & dosage; D009503:Neutropenia / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D016179:Granulocyte Colony-Stimulating Factor; D019804:Mesalamine; D015122:Mercaptopurine