title: Defect repair in rat mandible with hydroxyapatite cement compared to small intestine submucosa.
abstract: OBJECTIVE
  The aim of this study was to evaluate the bone formation in surgically created defects of rabbit mandibles by synthetic hydroxyapatite of calcium compared to small Intestine Submucosa.
  
  
  METHODS
  24 mice lineage Wisthar-Furth were used. A bony defect of 0,75 cm x 1,5 cm in mandibular ramus was accomplished in all animals. The hydroxyapatite implants were placed on the left hemimandiblein group I, small Intestine submucosa in group II, and the right served as control. The euthanasia was accomplished in the 40 degrees postoperative day, it was proceeded the macroscopic and histological analysis.
  
  
  RESULTS
  medium length in millimeters of the hemimandibless in the hydroxyapatite group was of 3,75, in the small intestine submucosa 3,03 and the control group was of 2,63 (p: 0,022). Histomorphometry study revealed new bone grown in 76,64% of the total area in hydroxyapatite group (p: 0,022). In Small Intestinal submucosa group new bone grown in 63,64% do total (p: 0,0022).
  
  
  CONCLUSIONS
  satisfactory bone integration was observed of the synthetic hydroxyapatite in that experimental model. Small intestinal submucosa cause osteoinduction
  
  
  CONCLUSIONS
  using hydroxyapatite of calcium resulted in formation of significantly larger volume fractions of new bone when compared to small intestinal submucosa group.
authors.affiliation: University Hospital of Paraná, Brazil.
authors.forename: Andréa Thomaz
authors.initials: AT
authors.lastname: Soccol
authors.forename: Silvio
authors.initials: S
authors.lastname: Bettega
authors.forename: Lúcia
authors.initials: L
authors.lastname: Noronha
authors.forename: Sheila
authors.initials: S
authors.lastname: Sass
authors.forename: Vanete T
authors.initials: VT
authors.lastname: Soccol
authors.forename: Marcos Renato
authors.initials: MR
authors.lastname: Scholz
authors.forename: Marcos
authors.initials: M
authors.lastname: Mocellin
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006882:Hydroxyapatites / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000637:transplantation*; D007421:Intestine, Small / Q000637:transplantation; D008338:Mandibular Injuries / Q000601:surgery*; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D051381:Rats; D011920:Rats, Inbred WF
chemical_list: D018786:Bone Substitutes; D006882:Hydroxyapatites; C475044:hydroxyapatite cement