Lewis acid mediated regioselective ring opening of benzylglycidol with dibenzyl phosphate: Short and attractive synthesis of dihydroxyacetone phosphate.
A novel, mild, and efficient method was described to introduce a dibenzyl phosphate by ring opening of benzylglycidol mediated by Lewis acids. This methodology was used as a key step for synthesizing the dihydroxyacetone phosphate (DHAP) in only three steps with an overall yield of 74% from the commercially available racemic benzylglycidol.
Meyer
Odile
O
Université Louis Pasteur, CNR LC3-UMR 7177, Institut Le Bel, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France.
Ponaire
Sarah
S
Rohmer
Michel
M
Grosdemange-Billiard
Catherine
C