Lithiation directed by amino alkoxides. Application to the synthesis of new disubstituted dihydrodipyridopyrazines.
The synthesis of new 4,6-disubstituted dihydrodipyridopyrazines starting from corresponding carboxaldehydes via lithiation directed by alpha-amino alkoxides is described. The N,N,N'-trimethylethylenediamine was used as amine component for in situ formation of the alpha-amino alkoxides. After optimization, this reaction allowed easy access to new interesting starting materials for further applications by palladium-catalyzed reactions.
Grig-Alexa
Irina-Claudia
IC
Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France.
Fînaru
Adriana-Luminita
AL
Caubère
Paul
P
Guillaumet
Gérald
G