title: Mycobacterium tuberculosis complex and mycobacterial heat shock proteins in lymph node tissue from patients with pulmonary sarcoidosis.
abstract: We demonstrated that not whole Mycobacterium tuberculosis but its particular antigens, hsp70(Mtb), hsp65(Mtb), and hsp16(Mtb), are present in lymph node tissues of patients with sarcoidosis (SA). hsp16(Mtb) occurs in the early stage of SA, whereas hsp70(Mtb) occurs in stage II of SA. hsp65(Mtb) is highly expressed in the capillary vessels in lymph node tissues in patients with SA.
authors.affiliation: Department of Pathophysiology, Medical University of Gdansk, Debinki 7 str., 80-211 Gdansk, Poland. aduban@amg.gda.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Dubaniewicz
authors.forename: Miroslawa
authors.initials: M
authors.lastname: Dubaniewicz-Wybieralska
authors.forename: Adam
authors.initials: A
authors.lastname: Sternau
authors.forename: Zofia
authors.initials: Z
authors.lastname: Zwolska
authors.forename: Ewa
authors.initials: E
authors.lastname: Izycka-Swieszewska
authors.forename: Ewa
authors.initials: E
authors.lastname: Augustynowicz-Kopec
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Skokowski
authors.forename: Mahavir
authors.initials: M
authors.lastname: Singh
authors.forename: Lech
authors.initials: L
authors.lastname: Zimnoch
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D018834:Chaperonin 60; D018833:Chaperonins / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000378:metabolism / Q000472:pathogenicity*; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis* / Q000382:microbiology; D014376:Tuberculosis / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D001426:Bacterial Proteins; D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins; C444642:HSP70 protein, Mycobacterium tuberculosis; D006360:Heat-Shock Proteins; C113725:HspA protein, bacteria; C074119:heat-shock protein 65, Mycobacterium; D018833:Chaperonins