title: Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV.
abstract: Genotype E hepatitis B virus (HBV) was detected in two Argentine sisters exhibiting an African mitochondrial lineage. One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A HBsAg escape mutant without anti-HBs antibodies. Both sisters carried an unusual L209V substitution within HBsAg.
authors.affiliation: Departamento Microbiología, Centro para el Estudio de Hepatitis Virales, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 Piso 11, 1121 Buenos Aires, Argentina.
authors.forename: Verónica L
authors.initials: VL
authors.lastname: Mathet
authors.forename: María L
authors.initials: ML
authors.lastname: Cuestas
authors.forename: Vanesa
authors.initials: V
authors.lastname: Ruiz
authors.forename: María L
authors.initials: ML
authors.lastname: Minassian
authors.forename: Cintia
authors.initials: C
authors.lastname: Rivero
authors.forename: Julieta
authors.initials: J
authors.lastname: Trinks
authors.forename: Graciela
authors.initials: G
authors.lastname: Daleoso
authors.forename: Liliana M
authors.initials: LM
authors.lastname: León
authors.forename: Andrea
authors.initials: A
authors.lastname: Sala
authors.forename: Beatriz
authors.initials: B
authors.lastname: Libellara
authors.forename: Daniel
authors.initials: D
authors.lastname: Corach
authors.forename: José R
authors.initials: JR
authors.lastname: Oubiña
mesh_terms: D000293:Adolescent; D000328:Adult; D001118:Argentina; D044383:Black People; D002353:Carrier State / Q000821:virology; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D009154:Mutation; D010802:Phylogeny; D014611:Vaccination
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines