Ropivacaine may have advantages compared to bupivacaine in porcine endotoxemic shock.
Patients that undergo major abdominal surgery often receive epidural postoperative analgesia. Septic complications are frequently seen in this cohort. In a porcine model of endotoxemic shock, resembling human gram-negative septic shock, we evaluated the effects of two widely used local anaesthetics, bupivacaine and ropivacaine given intravenously. In the endotoxin-ropivacaine group mixed venous saturation and platelet count were higher as compared to endotoxemic controls. Mean arterial blood pressure and platelet count were higher in ropivacaine-endotoxin pigs than in bupivacaine-endotoxin ones. Bupivacaine augmented endotoxin-mediated decrease in left ventricular stroke work index. Ropivacaine displays pathophysiological advantages compared to bupivacaine in septic shock, which may be explained by improved tissue perfusion by ropivacaine.
Mutschler
Diana K
DK
Department of Surgical Sciences, Anaesthesia and Intensive Care, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
Gustafsson
Urban
U
Basu
Samar
S
Larsson
Anders O
AO
Eriksson
Mats B
MB
D000577:Amides / Q000494:pharmacology / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects; D010976:Platelet Count; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000077212:Ropivacaine; D012772:Shock, Septic / Q000188:drug therapy*; D013318:Stroke Volume / Q000187:drug effects; D034421:Sus scrofa; D016277:Ventricular Function, Left / Q000187:drug effects
D000577:Amides; D000779:Anesthetics, Local; D020011:Protective Agents; D000077212:Ropivacaine; D002045:Bupivacaine