title: Clinical features of soft bipolarity in major depressive inpatients.
abstract: Because of the difficulties of ascertaining episode of hypomania by past history of the patients, it is of clinical value to find variables which predict the development of bipolar II disorder in depressive patients. Taking advantage of relatively long hospitalization, the authors tried to elucidate fine clinical features of the soft bipolarity. The subjects were 39 patients with Major Depressive Episode, diagnosed according to the 4th edition of the Diagnostic and Statistical Manual criteria. Among them, 15 patients were diagnosed as bipolar II disorder (BPII), whereas 24 patients were with unipolar depression (UP), using a structured clinical interview to assess the mood spectrum (SCI-MOODS). In addition to ordinary clinical and demographic variables, the authors studied fine symptomatology of depression, premorbid personality, and interpersonal relationship. Continuous variables were analyzed by t-test. Categorical variables were tested by chi2 analysis. In terms of premorbid personality, manic type (Zerssen) was found more frequently in BPII (UP 2/24, BPII 9/15, P < 0.05). Patients with BPII tended to show apparently quick disappearance of depressive symptoms (UP 2/24, BPII 9/15, P = 0.01). The most prominent result was a high prevalence of comorbidity of borderline personality disorder (BPD) among BPII (UP 0/24, BPII 6/15, P = 0.02). As Akiskal indicated that mood lability represents the most powerful predictor of hypomanias, patients with BPII showed quick response in mood to admission. The current subjects with BPII had high frequency of manic type of premorbid personality, indicating the usefulness of this variable for the prediction of hypomanias. Finally, the authors could observe development of BPD during hospitalization exclusively among BPII, to support the possibility of BPD as a state effect of BPII.
authors.affiliation: Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan. utsumi@med.teikyo-u.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Utsumi
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
authors.forename: Iwao
authors.initials: I
authors.lastname: Shimada
authors.forename: Mayuko
authors.initials: M
authors.lastname: Mabuchi
authors.forename: Takuro
authors.initials: T
authors.lastname: Motonaga
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ohtani
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Nanko
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000523:psychology*; D003865:Major Depressive Disorder / Q000523:psychology*; D003937:Diagnosis, Differential; D005260:Female; D006760:Hospitalization; D006801:Humans; D007398:Interpersonal Relations; D007564:Japan; D007902:Length of Stay; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D010551:Personality; D011567:Psychiatric Department, Hospital; D011569:Psychiatric Status Rating Scales; D012727:Sex Characteristics