Creatol, an oxidative product of creatinine in kidney transplant patients, as a useful determinant of renal function: a preliminary study.
Creatol (CTL, 5-hydroxycreatinine) is a creatinine (Cr) oxidative metabolite, which was originally isolated from the urine of patients with chronic renal failure, representing a candidate for a uremic toxin. The effectiveness of CTL as an indicator of oxidative stress after kidney transplantation has not been reported. Therefore, we examined the relation between the change in oxidative stress (using CTL) in renal transplant patients and their change in renal function (using Cr). The serum Cr and serum and urine CTL were examined in five renal transplant patients. Serum CTL closely correlated with serum Cr. Serum CTL also correlated with urine CTL, but in some cases there was a time lag. Both the ratio of CTL/(Cr) and serum CTL observed in patient 2 were slow to improve after transplantation. The process through which oxidative stress was reduced was shown by the index of renal damage correlated with kidney function oxidative stress (using serum CTL) after transplantation. Our data suggested that CTL/Cr may be a good indicator of graft prognosis.
Matsumoto
S
S
Department of Urology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan. matsums@med.kindai.ac.jp
Hanai
T
T
Matsuura
T
T
Uemura
H
H
Nishioka
T
T
Akiyama
T
T
D000017:ABO Blood-Group System; D015415:Biomarkers / Q000097:blood; D001787:Blood Group Incompatibility; D003404:Creatinine / Q000031:analogs & derivatives* / Q000097:blood* / Q000652:urine; D005190:Family; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000652:urine; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors
D000017:ABO Blood-Group System; D015415:Biomarkers; C064402:creatol; D003404:Creatinine