Dark immunofluorescence: correlation with serum immunoglobulin abnormalities.
Occasional serum samples (<0.5%) tested by indirect immunofluorescence showed less fluorescence than did negative-control serum. A retrospective review of these patients' serum immunoglobulins revealed a high percentage of abnormalities (71%, versus 22% of controls). We suggest that this observation should be reported when seen and that the clinician should be alerted to an association with immunoglobulin abnormalities.
List
J
J
Department of Haematology Immunology Section, Colchester General Hospital, Turner Road, Colchester, Essex CO4 5JL, United Kingdom. jenny.list@essexrivers.nhs.uk
Buckland
M S
MS
Thobhani
B
B
Sheed
C J
CJ
Mann
J C
JC
Claxton
M
M
Heelan
B
B
D000293:Adolescent; D000328:Adult; D000818:Animals; D002460:Cell Line; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D000882:Haplorhini; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012377:Rodentia; D013194:Staining and Labeling
D007136:Immunoglobulins