title: [A resected case of effective treatment with TS-1 and CDDP for advanced gastric cancer with carcinomatous ascites].
abstract: We encountered a resected case of advanced gastric cancer after successful chemotherapy. The patient remained alive in good condition without any signs of recurrence at 2 years and 8 months after surgery. The 40-year-old woman initially complained of low abdominal pain, which was diagnosed as gastric cancer with metastasis of ovaries and carcinomatous ascites. We administered TS-1 (100 mg/body/day) for 3 weeks followed by 2-week rest and CDDP (60 mg/body) on the 8th day of one cycle. After 3 cycles of treatment, carcinomatous ascites disappeared and the ovarian lesion was reduced. The patient underwent total gastrectomy, ileocecal resection, cholecystectomy and radical hysterectomy. The antitumor efficacy of the treatment was histologically Grade 2. We administered 17 cycles of TS-1 treatment, and the patient is alive in good condition at this writing. This shows that TS-1 and CDDP may have potent therapeutic efficacy in advanced gastric cancer patients. For the future, the safety and efficacious administration of TS-1 and CDDP should be examined further.
authors.affiliation: Dept. of Surgery, Ogori Daiichi General Hospital.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Toshimitsu
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Matoba
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ozasa
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001201:Ascites / Q000188:drug therapy / Q000209:etiology*; D002763:Cholecystectomy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007044:Hysterectomy; D007082:Ileum / Q000601:surgery; D010051:Ovarian Neoplasms / Q000556:secondary* / Q000601:surgery; D010094:Oxonic Acid / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin