Synthesis of a bistetrahydrofuran C17-C32 fragment of the polyether antibiotic ionomycin.
A Zn-initiated triepoxide cascade cyclization reaction was employed for the synthesis of the bistetrahydrofuran core segment of the polyether ionophore antibiotic ionomycin.
Marshall
James A
JA
Department of Chemistry, University of Virginia, , PO Box 400319, Charlottesville, Virginia 22904, USA. jam5x@virginia.edu
Mikowski
Ann M
AM
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis*; D015759:Ionomycin / Q000737:chemistry*; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D005663:Furans; C018674:tetrahydrofuran; D015759:Ionomycin