title: Receptor for advanced glycation end products and the cardiovascular complications of diabetes and beyond: lessons from AGEing.
abstract: The presence of elevated blood glucose levels characterizes the diabetic state. Hyperglycemia may be caused by a number of underlying factors; however, the consequences of chronically elevated glucose are similar. Both the macrovasculature and microvasculature are exquisitely sensitive to the long-term effects of elevated blood glucose. Cardiovascular disease remains the leading cause of morbidity and mortality in diabetes, regardless of the underlying cause of hyperglycemia. Although other substrates, such as DNA, are susceptible to glycation, this article addresses the impact of nonenzymatic glycation on the proteome. The impact of Advanced Glycation End products (AGEs) on alteration of protein function and signal transduction mechanisms contributes to the pathogenesis of diabetes complications. This suggests that blocking the generation or molecular impact of AGEs may modulate the complications of diabetes.
authors.affiliation: Columbia University Medical Center, 630 West 168th Street, P&S 17-501, New York, NY 10032, USA.
authors.forename: Shi Fang
authors.initials: SF
authors.lastname: Yan
authors.forename: Shi Du
authors.initials: SD
authors.lastname: Yan
authors.forename: Kevan
authors.initials: K
authors.lastname: Herold
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Ramsamy
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D050197:Atherosclerosis; D002318:Cardiovascular Diseases / Q000209:etiology*; D023903:Coronary Restenosis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000209:etiology / Q000628:therapy; D004195:Disease Models, Animal; D017127:Glycation End Products, Advanced; D006801:Humans; D007249:Inflammation / Q000150:complications; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic