Evaluating brain activity in obsessive-compulsive disorder: preliminary insights from a multivariate analysis.
Obsessive-compulsive disorder (OCD) has been linked to a dysfunction of brain corticostriatal networks, although functional imaging studies of OCD rarely apply network-sensitive analysis methods. In this study, we compared a univariate and a multivariate analysis of PET data in OCD patients and healthy subjects; the latter approach was considered more suitable for characterizing functional networks of brain activity. Although both methods suggested there was abnormal corticostriatal activity in OCD patients, the nature, extent and magnitude of this activity was clearly enhanced by the multivariate approach. Implications for the analysis of such studies are discussed.
Harrison
Ben J
BJ
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia. habj@unimelb.edu.au
Yücel
Murat
M
Shaw
Marnie
M
Kyrios
Michael
M
Maruff
Paul
P
Brewer
Warrick J
WJ
Purcell
Rosemary
R
Velakoulis
Dennis
D
Strother
Stephen C
SC
Scott
Andrew M
AM
Nathan
Pradeep J
PJ
Pantelis
Christos
C
D000328:Adult; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000378:metabolism; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000378:metabolism* / Q000523:psychology; D049268:Positron-Emission Tomography; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires