title: Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature.
abstract: We report the case of a 51-year-old man with an asymptomatic indurated plaque on the chest wall that was surgically excised and submitted for histopathological examination. Microscopically, the dermis was occupied by a neoplastic process with spindle-shaped cells arranged in longitudinal fascicles with cytologic atypia; the abundant sclerotic stroma was composed of hyaline material. Tumoral cells showed immunohistochemical reactivity to smooth muscle markers. The diagnosis was desmoplastic leiomyosarcoma of the skin. This unusual entity is identified and discussed, and we review the literature.
authors.affiliation: Hospital General Universitario de Valencia - Pathology, Av Tres Cruces s/n Valencia, Spain. berzal_fer@gva.es
authors.forename: Fernanda
authors.initials: F
authors.lastname: Berzal-Cantalejo
authors.forename: Vicente
authors.initials: V
authors.lastname: Sabater-Marco
authors.forename: Ana
authors.initials: A
authors.lastname: Pérez-Vallés
authors.forename: Miquel
authors.initials: M
authors.lastname: Martorell-Cebollada
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007890:Leiomyosarcoma / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D018235:Smooth Muscle Tumor / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor