title: The effects of clomipramine hydrochloride in cats with psychogenic alopecia: a prospective study.
abstract: A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. Twenty-five cats were randomly assigned to receive clomipramine hydrochloride (0.5 mg/kg orally q 24 hours) or placebo for 56 days. Eleven cats in each group completed the trial. The results of this study showed that clomipramine hydrochloride failed to demonstrate significant changes in the number of grooming bouts, hair regrowth, and the area of alopecia in cats with psychogenic alopecia when compared to a placebo. It was uncertain whether these results reflected a lack of drug efficacy, insufficient treatment duration, or an insufficient number of cases enrolled.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55108, USA.
authors.forename: Petra A
authors.initials: PA
authors.lastname: Mertens
authors.forename: Sheila
authors.initials: S
authors.lastname: Torres
authors.forename: Carl
authors.initials: C
authors.lastname: Jessen
mesh_terms: D000505:Alopecia / Q000188:drug therapy / Q000523:psychology / Q000662:veterinary*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000523:psychology; D002415:Cats; D002997:Clomipramine / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006120:Grooming / Q000187:drug effects*; D006197:Hair / Q000187:drug effects / Q000254:growth & development; D008297:Male; D011446:Prospective Studies; D016728:Self-Injurious Behavior / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine