Fluorinated and hemifluorinated surfactants derived from maltose: synthesis and application to handling membrane proteins in aqueous solution.
Two novel fluorinated surfactants have been obtained by grafting by radical reaction either a fluorocarbon or an ethyl end-capped fluorocarbon chain onto the double bond of beta-D-allyl maltose. The two compounds thus obtained form polydisperse aggregates in water. They can keep membrane proteins water-soluble, but the protein/surfactant complexes are polydisperse, which affects neither the native state nor the stability of the proteins.
Polidori
Ange
A
Université d'Avignon et des Pays du Vaucluse, Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, 33 rue Louis Pasteur, F-84000 Avignon, France.
Presset
Marc
M
Lebaupain
Florence
F
Ameduri
Bruno
B
Popot
Jean-Luc
JL
Breyton
Cécile
C
Pucci
Bernard
B
D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008320:Maltose / Q000737:chemistry*; D008565:Membrane Proteins / Q000378:metabolism*; D011487:Protein Conformation; D013499:Surface Properties; D013501:Surface-Active Agents / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
D006845:Hydrocarbons, Fluorinated; D008565:Membrane Proteins; D013501:Surface-Active Agents; D014867:Water; D008320:Maltose