title: Correlation between CD4 count and intensity of Candida colonization in the oropharynx of HIV-infected/ AIDS patient.
abstract: OBJECTIVE
  To know the correlation between CD4 count and intensity of Candida colonizations in the oropharynx of HIV-infected/AIDS patients, to get the prevalence of oropharyngeal candidiasis (OPC), and to know what kind of Candida species that causes oropharynx candidiasis of HIV-infected/AIDS patients.
  
  
  METHODS
  A cross-sectional study was conducted in HIV-infected/AIDS patients who came as outpatients and inpatients in Cipto Mangunkusumo Hospital. The patients were interviewed, physically examined, their CD4 counts were checked, and their mouth rinse samples were taken to be cultured. Candida species was identified in CHROMagar media, and data were processed.
  
  
  RESULTS
  From September 2004 until January 2005, 60 HIV-infected/AIDS patients were included in this study. There were 86.7% males and 13.3% females. Majority of the patients were from 20-30 years age group (85%). The most frequent transmission was among drug users (75%) followed by sexual contact (18.3%). The median of CD4 counts was 100 cells/il, ranged from 2 to 842 cells/il. Proportion of the OPC was 63.3% (CI 95% = 51.1 - 75.5). From 59 Candida isolates in this study, 74.58% were C. albicans. Candida non C. albicans species that were found in this trial were C. krusei, C. parapsilosis and C. tropicalis. There was significant correlation between low CD4 counts and high intensity of Candida colonization on the oropharynx of the subjects (r = -0.756).
  
  
  CONCLUSIONS
  There was strong negative correlation (r = -0.756) between CD4 count and intensity of Candida colonization in the oropharynx of HIV-infected/AIDS patients. Proportion of OPC in this study was 63.3%. The most frequent species found in the oropharynx of the subjects was C. albicans.
authors.affiliation: Departement of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta.
authors.forename: Ivo Novita Sah
authors.initials: IN
authors.lastname: Bandar
authors.forename: Djoko
authors.initials: D
authors.lastname: Widodo
authors.forename: Samsuridjal
authors.initials: S
authors.lastname: Djauzi
authors.forename: Abdul
authors.initials: A
authors.lastname: Muthalib
authors.forename: Sidartawan
authors.initials: S
authors.lastname: Soegondo
authors.forename: Retno
authors.initials: R
authors.lastname: Wahyuningsih
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000382:microbiology*; D000328:Adult; D018791:CD4 Lymphocyte Count; D002175:Candida / Q000302:isolation & purification*; D002180:Candidiasis, Oral / Q000276:immunology / Q000382:microbiology*; D003430:Cross-Sectional Studies; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D009960:Oropharynx / Q000382:microbiology; D010608:Pharyngeal Diseases / Q000276:immunology / Q000382:microbiology*