title: Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: opportunities and limitations.
abstract: This is a discussion of the following two papers in this special issue on adaptive designs: 'Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: General concepts' by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer, and 'Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: Applications and practical considerations' by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer.
authors.affiliation: Department of Mathematical Sciences, University of Bath, Bath BA2 7AY, UK. cj@maths.bath.ac.uk
authors.forename: Christopher
authors.initials: C
authors.lastname: Jenniso
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Turnbull
mesh_terms: D001699:Biometry; D017322:Clinical Trials, Phase II as Topic / Q000706:statistics & numerical data*; D017326:Clinical Trials, Phase III as Topic / Q000706:statistics & numerical data*; D023381:Endpoint Determination / Q000706:statistics & numerical data*; D015233:Models, Statistical; D018579:Patient Selection; D012107:Research Design / Q000706:statistics & numerical data*