title: Choroid plexus papilloma in a Scottish highland cow.
abstract: Choroid plexus papilloma, a rare tumour in bovids, arising from the roof of the third ventricle was diagnosed at necropsy in a 4-year-old Scottish Highland cow. The animal presented with a 2-month history of progressive ataxia, ventromedial strabismus, and hyperaesthesia. Neoplastic epithelial cells were positive immunohistochemically for pancytokeratin and S-100, and negative for GFAP. Ultrastructurally, epithelial cells were characterized by intercellular junctions, zonulae adherens, and zonulae occludens. Neither cilia nor basal bodies were identified. The gross, microscopical, immunohistochemical and ultrastructural findings were consistent with those of a choroid plexus papilloma.
authors.affiliation: Diagnostic Center for Population and Animal Health, Department of Pathobiology and Diagnostic Investigation, Michigan State University College of Veterinary Medicine, Lansing, MI 48910.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hoenerhoff
authors.affiliation: Animal Disease Diagnostic Laboratory, Purdue University, Lafayette, IN 47905, USA.
authors.forename: E
authors.initials: E
authors.lastname: Janovitz
authors.affiliation: Animal Disease Diagnostic Laboratory, Purdue University, Lafayette, IN 47905, USA.
authors.forename: J
authors.initials: J
authors.lastname: Ramos-Vara
authors.affiliation: Diagnostic Center for Population and Animal Health, Department of Pathobiology and Diagnostic Investigation, Michigan State University College of Veterinary Medicine, Lansing, MI 48910. Electronic address: kiupel@dcpah.msu.edu.
authors.forename: M
authors.initials: M
authors.lastname: Kiupel
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002831:Choroid Plexus / Q000378:metabolism / Q000473:pathology; D016545:Choroid Plexus Neoplasms / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D007365:Intercellular Junctions / Q000648:ultrastructure; D007633:Keratins / Q000235:genetics / Q000378:metabolism; D020288:Papilloma, Choroid Plexus / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D009418:S100 Proteins; D007633:Keratins