title: In vitro antifungal-drug susceptibilities of mycelial and yeast forms of Penicillium marneffei isolates in Cambodia.
abstract: Penicillium marneffei infection is an important disease among human immunodeficiency virus patients in Southeast Asia. The in vitro antifungal-drug susceptibilities of 29 clinical isolates and 5 isolates from bamboo rats collected from 2002 to 2004 were determined. The P. marneffei yeast form is more susceptible than the mycelial form to amphotericin B and ketoconazole, while the mycelial and yeast forms displayed similar susceptibilities to flucytosine and itraconazole. The MICs of fluconazole were higher for both mycelial and yeast forms.
authors.affiliation: Laboratory of Medical Microbiology, Unit of Clinical Testing, Institut Pasteur du Cambodge, 5 Boulevard Monivong, BP 983, Phnom Penh, Cambodia. sborann@pasteur-kh.org
authors.forename: Borann
authors.initials: B
authors.lastname: Sar
authors.forename: Sambo
authors.initials: S
authors.lastname: Boy
authors.forename: Chantary
authors.initials: C
authors.lastname: Keo
authors.forename: Chan Chhaya
authors.initials: CC
authors.lastname: Ngeth
authors.forename: Narom
authors.initials: N
authors.lastname: Prak
authors.forename: Mich
authors.initials: M
authors.lastname: Vann
authors.forename: Didier
authors.initials: D
authors.lastname: Monchy
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Sarthou
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D025282:Mycelium / Q000187:drug effects*; D010407:Penicillium / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole