title: Disseminated extramedullary myeloid tumor of the gallbladder without involvement of the bone marrow.
abstract: Extramedullary myeloid tumors (myeloid sarcomas) are rare neoplasms that are composed of myeloid precursors. They usually arise concurrently with a diagnosis of acute myeloid leukemia, chronic myeloid leukemia, or other myeloproliferative disorders. They may also indicate relapsing disease in a patient with a prior history of leukemia or myeloproliferative disorder. We present our findings of a 63-year-old female diagnosed with extramedullary myeloid tumor first presenting in the gallbladder. She subsequently developed respiratory failure; pre- and postmortem bone marrow studies were negative for leukemia by morphology, flow cytometry, and karyotypic analysis. However, the myeloid neoplasm was disseminated throughout most of her remaining organs. Immunohistochemical stains of the cells indicated a neoplasm of myelomonocytic derivation (CD4, CD43, CD45, CD68, myeloperoxidase, and lysozyme positive). To our knowledge, this is the first report of an extramedullary myeloid neoplasm of the gallbladder with disseminated disease without involvement of the bone marrow.
authors.affiliation: Department of Pathology, University of Arizona, Tucson, Arizona, USA. abartley@email.arizona.edu
authors.forename: Angela N
authors.initials: AN
authors.lastname: Bartley
authors.forename: Craig L
authors.initials: CL
authors.lastname: Nelson
authors.forename: Donald H
authors.initials: DH
authors.lastname: Nelson
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Fuchs
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009113:Muramidase / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D023981:Sarcoma, Myeloid / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009195:Peroxidase; D009113:Muramidase