title: Susceptibilities of Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime.
abstract: We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 microg/ml to 0.75 microg/ml, 0.094 microg/ml to 1.5 microg/ml, and 1 microg/ml to 12 microg/ml for ertapenem, meropenem, and cefepime, respectively. Based on our excellent in vitro carbapenem susceptibility results, in vivo studies using ertapenem and meropenem in a rabbit model of P. acnes endophthalmitis are warranted.
authors.affiliation: Division of Infectious Disease, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11042, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Shames
authors.forename: Farhana
authors.initials: F
authors.lastname: Satti
authors.forename: Ernestine M
authors.initials: EM
authors.lastname: Vellozzi
authors.forename: Miriam A
authors.initials: MA
authors.lastname: Smith
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D000077727:Ertapenem; D005123:Eye / Q000382:microbiology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000187:drug effects*; D011817:Rabbits; D013845:Thienamycins / Q000494:pharmacology*; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013845:Thienamycins; D047090:beta-Lactams; D000077723:Cefepime; D000077731:Meropenem; D000077727:Ertapenem