Enantiopure beta3-amino acids-2,2-d2 via homologation of proteinogenic alpha-amino acids.
A procedure for the synthesis of enantiopure beta3-amino acids from proteinogenic alpha-amino acids, developed by our group a few years ago, has been modified to enable the production of C-2 fully deuterated, C-protected beta3-amino acids and, even more important, the synthesis of valuable deuterium labelled N(Boc)-protected chiral synthons, such as 2-aminoalcohols, 2-aminoiodides, and beta3-amino nitriles.
Caputo
R
R
Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II, Napoli, Italy. rocaputo@unina.it
Longobardo
L
L
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000605:Amino Alcohols / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
D000596:Amino Acids; D000605:Amino Alcohols; D009570:Nitriles; D003903:Deuterium