title: Assessing sensory function in locomotor systems using neuro-mechanical simulations.
abstract: Computer simulations are being used increasingly to gain an understanding of the complex interactions between the neuronal, sensory, muscular and mechanical components of locomotor systems. Recent neuro-mechanical simulations of walking in humans, cats and insects, and of swimming in lampreys, have provided new information on the functional role of specific groups of sensory receptors in regulating locomotion. As we discuss in this review, these studies also make it clear that a full understanding of the neural and mechanical mechanisms that underlie locomotion can be achieved only by using simulations in parallel with physiological investigations. The widespread implementation of this approach would be enhanced by the development of freely available and easy-to-use software tools.
authors.affiliation: Department of Physiology, University of Alberta, Edmonton, T6G 2H7, Canada. keir.pearson@ualberta.ca
authors.forename: Keir
authors.initials: K
authors.lastname: Pearson
authors.forename: Orjan
authors.initials: O
authors.lastname: Ekeberg
authors.forename: Ansgar
authors.initials: A
authors.lastname: Büschges
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D008124:Locomotion / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000294:innervation* / Q000502:physiology*; D012677:Sensation / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*