Chronic active thrombotic microangiopathy in native and transplanted kidneys.
We report 2 complicated cases of thrombotic microangiopathy with chronic features and active components. The first case was a 36-yr-old woman with positive anti-DNA antibody and possible lupus cerebritis, who developed thrombotic microangiopathy secondary to a series of syndromes, including preeclampsia and anti-phospholipid antibody syndrome. Renal biopsy revealed no evidence of lupus nephritis and her renal function returned to normal 1 week after the biopsy. The second case was a 46-yr-old man who developed thrombotic microangiopathy of unknown etiology, which led to end-stage renal disease within 6 mo. The patient received a living related-donor transplant, but thrombotic microangiopathy recurred in the donor kidney only 40 days after the renal transplantation.
Zhang
Ping L
PL
Laboratory Medicine, Geisinger Medical Center, 100 North Academy, Danville, PA 17822, USA. plzhang@geisinger.edu
Prichard
Jeffery W
JW
Lin
Fan
F
Shultz
Michael F
MF
Malek
Sayeed K
SK
Shaw
John H
JH
Hartle
James E
JE
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications; D002908:Chronic Disease; D005260:Female; D050533:Glomerular Basement Membrane / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology; D016030:Kidney Transplantation / Q000473:pathology; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D013921:Thrombocytopenia / Q000209:etiology; D013927:Thrombosis / Q000150:complications*