title: [Recent findings regarding the treatment of late-onset depression with vascular brain lesions. A literature review].
abstract: BACKGROUND
  Late-onset depression with vascular brain lesions is showing increased resistance to antidepressive pharmacotherapy.
  
  
  OBJECTIVE
  To give an overview of alternative treatment options.
  
  
  METHODS
  We conducted a literature search via PubMed using the key words: 'late-onset depression', 'white matter lesions', 'cerebrovascular pathology' and 'treatment' and thereby a searchfor all available clinical studies about the treatment described in combination with the key words 'vascular depression', or 'late-onset depression' and 'white matter lesions'.
  
  
  RESULTS
  Electroconvulsive therapy, repetitive transcranial magnetic stimulation and nimodipine au,gmentation have beneficial effects on vascular depression.
  
  
  CONCLUSIONS
  The treatment options mentioned are promising, but there is a need for further clinical studies.
authors.affiliation: Universitair Centrum Sint-Jozef te Kortenberg.
authors.forename: V
authors.initials: V
authors.lastname: Jans
authors.forename: F
authors.initials: F
authors.lastname: Bouckaert
authors.forename: V
authors.initials: V
authors.lastname: Wils
authors.forename: J
authors.initials: J
authors.lastname: Peuskens
mesh_terms: D000367:Age Factors; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D003863:Depression / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D006801:Humans; D009553:Nimodipine / Q000627:therapeutic use; D012307:Risk Factors; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D009553:Nimodipine