title: Evaluation of the role of nuclear factor-kappaB signaling in liver injury using genetic animal models.
abstract: Most chronic liver diseases are not sufficiently treatable at present and very often progress to liver fibrosis and liver cirrhosis. Several recent studies have suggested that cytokines and cytokine-activated inflammatory signaling pathways might play an important role in the mediation of liver injury. Although pro-inflammatory signaling pathways such as nuclear factor (NF)-kappaB have evolved primarily for host defense to infections, they appear to be involved in the pathogenesis of inflammatory diseases and may mediate liver injury in response to a variety of agents and pathogens. Herein is summarized briefly some recent findings concerning the role of NF-kappaB in different models of liver injury based on transgenic and knockout animal technology.
authors.affiliation: EMBL Mouse Biology Program, Monterotondo, Italy.
authors.forename: Tom
authors.initials: T
authors.lastname: Luedde
authors.forename: Naiara
authors.initials: N
authors.lastname: Beraza
authors.forename: Christian
authors.initials: C
authors.lastname: Trautwein
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016207:Cytokines / Q000276:immunology; D008107:Liver Diseases / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D008957:Models, Genetic; D016328:NF-kappa B / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D016328:NF-kappa B