Overview of dosimetry for Systemic Targeted Radionuclide Therapy (STaRT).
The purposes of systemic targeted radionuclide therapy dosimetry include compiling a database of normal organ radiation-absorbed doses that are carrier- and radionuclide-specific, and assuring that the normal organ radiation doses are within a safe range before therapy. Also of importance is quantitation of radiation delivery to tumors vs. normal tissues to correlate absorbed dose with tumor control. For agents with significant and variable excretion, estimates of individual patient distribution/clearance may be needed to optimize the dose-response relationship.
Wessels
Barry W
BW
Department of Radiation Oncology, Comprehensive Cancer Care Center, Case Western Reserve University, Cleveland, OH, USA. Wessels@uhhs.com
Syh
Joseph H
JH
Meredith
Ruby F
RF
D001921:Brain / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D006801:Humans; D016499:Radioimmunotherapy / Q000379:methods*; D011874:Radiometry / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D012062:Relative Biological Effectiveness; D014018:Tissue Distribution
D019275:Radiopharmaceuticals