title: "Click" synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases.
abstract: By using "Click Chemistry", we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Mahesh
authors.initials: M
authors.lastname: Uttamchandani
authors.forename: Junqi
authors.initials: J
authors.lastname: Li
authors.forename: Mingyu
authors.initials: M
authors.lastname: Hu
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D001665:Binding Sites; D003878:Dermatoglyphics; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D015335:Molecular Probes / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D040901:Proteomics
chemical_list: D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D015335:Molecular Probes; D020782:Matrix Metalloproteinases