Modelling dynamics of the type I interferon response to in vitro viral infection.
Innate immunity is crucial in the early stages of resistance to novel viral infection. The family of cytokines known as the interferons (IFNs) forms an essential component of this system: they are responsible for signalling that an infection is underway and for promoting an antiviral response in susceptible cells. We construct a spatial stochastic model, parameterized by experimental data and informed by analytic approximation, to capture the dynamics of virus-IFN interaction during in vitro infection of Madin-Darby bovine kidney cell monolayers by Herpes simplex virus 1. The dose dependence of infection progression, subsequent monolayer destruction and IFN-beta production are investigated. Implications for in vivo infections, in particular the priming of susceptible cells by IFN-beta during infection, are considered.
Howat
Tom J
TJ
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. tjh44@cam.ac.uk
Barreca
Cristina
C
O'Hare
Peter
P
Gog
Julia R
JR
Grenfell
Bryan T
BT
D000818:Animals; D002417:Cattle; D002460:Cell Line; D002522:Chlorocebus aethiops; D003198:Computer Simulation; D018259:Herpesvirus 1, Human / Q000276:immunology*; D007370:Interferon Type I / Q000276:immunology* / Q000378:metabolism*; D007668:Kidney / Q000166:cytology; D018448:Models, Immunological; D013269:Stochastic Processes
D007370:Interferon Type I