title: Tyrosine-derived polycarbonate membrane in treating mandibular bone defects. An experimental study.
abstract: This study was designed to evaluate the suitability of a novel bioabsorbable material in treating bone defects. A poly(desaminotyrosyl-tyrosine-ethyl ester carbonate) (PDTE carbonate) membrane (thickness 0.2-0.3 mm) was implanted into the mandibular angle of 20 New Zealand White rabbits to cover a through-and-through defect (12 x 6 mm). In group 1, the defects were left unfilled but covered with membrane and in group 2 the defects were filled with bioactive glass mesh and covered with membrane, too. Controls were left uncovered and unfilled. The animals were followed for 6, 12, 24 and 52 weeks, respectively. The material was evaluated by qualitative analysis of histological reactions and newly formed bone. We found that PDTE carbonate elicited a modest foreign body reaction in the tissues, which was uniform throughout the study. New bone formation was seen in all samples after six weeks. Group 1 had more new bone formation until 24 weeks and after this the difference settled. Based on findings of this study it was concluded that PDTE carbonate membranes have good biocompatibility and are sufficient to enhance bone growth without additional supportive matrix.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Helsinki, 00014 Helsinki, Finland. antti.asikainen@helsinki.fi
authors.forename: Antti J
authors.initials: AJ
authors.lastname: Asikainen
authors.forename: Jukka
authors.initials: J
authors.lastname: Noponen
authors.forename: Christian
authors.initials: C
authors.lastname: Lindqvist
authors.forename: Mika
authors.initials: M
authors.lastname: Pelto
authors.forename: Minna
authors.initials: M
authors.lastname: Kellomäki
authors.forename: Hanne
authors.initials: H
authors.lastname: Juuti
authors.forename: Harri
authors.initials: H
authors.lastname: Pihlajamäki
authors.forename: Riitta
authors.initials: R
authors.lastname: Suuronen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001704:Biopolymers / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000502:physiology*; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods; D020007:Implants, Experimental; D008336:Mandibular Diseases / Q000601:surgery*; D008567:Membranes, Artificial; D011076:Polycarboxylate Cement / Q000627:therapeutic use; D011817:Rabbits; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers; D008567:Membranes, Artificial; D011076:Polycarboxylate Cement; C505373:poly(desaminotyrosyl-tyrosine-ethyl ester carbonate); C005506:polycarbonate; D014443:Tyrosine