Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model.
The effect of a main constituent ginsenoside Rg5 isolated from red ginseng and its metabolite ginsenoside Rh3 in a chronic dermatitis model was investigated. Ginsenosides Rg5 and Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis. These ginsenosides also reduced mRNA expressions of cyclooxygenase-2, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. The inhibition of ginsenoside Rh3 was more potent than that of ginsenoside Rg5. These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of IL-1beta and TNF-alpha produced by macrophage cells and of IFN-gamma produced by Th cells.
Shin
Yong-Wook
YW
College of Pharmacy, Kyung Hee University, 1, Hoegi, Dongdaemun-ku, Seoul 130-701, Korea.
Bae
Eun-Ah
EA
Kim
Dong-Hyun
DH
D000818:Animals; D002908:Chronic Disease; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005260:Female; D036145:Ginsenosides / Q000378:metabolism / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000096:biosynthesis; D053583:Interleukin-1beta / Q000096:biosynthesis; D051379:Mice; D008813:Mice, Inbred ICR; D010081:Oxazolone; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D036145:Ginsenosides; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; C055306:ginsenoside Rh3; D010081:Oxazolone; D007371:Interferon-gamma; D051546:Cyclooxygenase 2