title: Can neck size in elastase-induced aneurysms be controlled? A retrospective study.
abstract: OBJECTIVE
  Reproducible animal models with appropriate neck size are crucial for preclinical assessment of aneurysm therapies. Our purpose was to determine whether the neck size of elastase-induced aneurysms could be controlled by adjusting the position of the temporary occlusion balloon.
  
  
  METHODS
  Seventy-two elastase-induced aneurysms in rabbits were retrospectively analyzed. Three groups (group 1, n = 35; group 2, n = 32; group 3, n = 5) were defined according to different balloon position (lowest, intermediate, and highest, respectively) related to the origin of right common carotid artery (CCA). Aneurysm sizes in different groups were measured and compared; parent artery dilation was assessed as present or absent. The Wilcoxon rank sum test, the Fisher exact test, and the chi(2) test were used for statistics process.
  
  
  RESULTS
  The mean aneurysm neck diameter in group 1 was significantly wider than that in group 2 (P = .0001). The proportion of wide-necked (diameter of neck >4 mm) aneurysms in group 1 was significantly higher than that in group 2 (P = .0011). The mean dome/neck ratio in group 1 was smaller than that of group 2 (P = .0031). Aneurysm width and height and the frequency of parent artery dilation were not different in groups 1 and 2 (P = .43, P = .10, and P = .25). No aneurysms formed in group 3.
  
  
  CONCLUSIONS
  The neck size of elastase-induced aneurysms can be controlled by adjusting the position of the inflated balloon, with balloon positioning that bridges from the CCA to the subclavian/brachiocephalic arteries yielding narrow-necked aneurysms.
authors.affiliation: Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
authors.forename: Y H
authors.initials: YH
authors.lastname: Ding
authors.forename: D
authors.initials: D
authors.lastname: Dai
authors.forename: D A
authors.initials: DA
authors.lastname: Lewis
authors.forename: M A
authors.initials: MA
authors.lastname: Danielson
authors.forename: R
authors.initials: R
authors.lastname: Kadirvel
authors.forename: J N
authors.initials: JN
authors.lastname: Mandrekar
authors.forename: H J
authors.initials: HJ
authors.lastname: Cloft
authors.forename: D F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D000783:Aneurysm / Q000139:chemically induced / Q000000981:diagnostic imaging*; D015901:Angiography, Digital Subtraction; D000818:Animals; D021721:Balloon Occlusion; D016122:Brachiocephalic Trunk / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging* / Q000187:drug effects; D004195:Disease Models, Animal; D010196:Pancreatic Elastase; D011817:Rabbits; D013348:Subclavian Artery / Q000000981:diagnostic imaging
chemical_list: D010196:Pancreatic Elastase