title: Outcome of patients with acute coronary syndromes and moderate coronary lesions undergoing deferral of revascularization based on fractional flow reserve assessment.
abstract: OBJECTIVE
  To determine the outcome of consecutive patients with and without acute coronary syndromes (ACS) in whom revascularization was deferred on the basis of fractional flow reserve (FFR).
  
  
  BACKGROUND
  FFR < 0.75 correlates with ischemia on noninvasive tests and deferral of treatment on the basis of FFR is associated with low event rates in selected populations. Whether these low event rates apply to patients undergoing assessment of moderate stenoses in association with an ACS is not known and is an important clinical question.
  
  
  METHODS
  Retrospective analysis and 12 month follow-up of consecutive, moderate (50-70%) de novo coronary lesions assessed with FFR.
  
  
  RESULTS
  Revascularization was deferred in 120 lesions (111 patients) with FFR > or = 0.75. ACS was present in 35 patients (40 lesions). The clinical, angiographic and coronary hemodynamic characteristics of patients with and without ACS were similar. Among the 35 patients with ACS, there were 3 deaths, 1 MI, and 6 target vessel revascularizations (TVRs) (15% of lesions). Among the 76 patients without ACS, there were 5 deaths, 1 MI, and 7 TVR's (9% of lesions).
  
  
  CONCLUSIONS
  Deferral of revascularization based on FFR in patients with ACS and moderate coronary stenoses is associated with acceptable and low event rates at 1 year.
authors.affiliation: The Cardiovascular Division, Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia 22908, USA.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Fischer
authors.forename: Xin-Qun
authors.initials: XQ
authors.lastname: Wang
authors.forename: Habib
authors.initials: H
authors.lastname: Samady
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Sarembock
authors.forename: Eric R
authors.initials: ER
authors.lastname: Powers
authors.forename: Lawrence W
authors.initials: LW
authors.lastname: Gimple
authors.forename: Michael
authors.initials: M
authors.lastname: Ragosta
mesh_terms: D000208:Acute Disease; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013577:Syndrome; D016896:Treatment Outcome