Heparin binding nanostructures to promote growth of blood vessels.
Controlling new blood vessel formation is of interest in regenerative medicine and cancer treatment. Heparin, a biopolymer that binds to angiogenic growth factors, was used to nucleate the self-assembly of nanostructures from designed peptide amphiphile molecules. This process yields rigid nanofibers that display heparin chains to orient proteins for cell signaling. In vivo, the nanostructures stimulated extensive new blood vessel formation using nanogram amounts of growth-factor proteins that by themselves did not induce any detectable angiogenesis.
Rajangam
Kanya
K
Department of Biomedical Engineering, Institute for BioNanotechnology in Medicine, Northwestern University, Evanston, Illinois 60208, USA.
Behanna
Heather A
HA
Hui
Michael J
MJ
Han
Xiaoqiang
X
Hulvat
James F
JF
Lomasney
Jon W
JW
Stupp
Samuel I
SI
D042501:Angiogenic Proteins / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D001665:Binding Sites; D006493:Heparin / Q000008:administration & dosage* / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000502:physiology*; D011485:Protein Binding; D051381:Rats; D012171:Retinal Vessels / Q000187:drug effects* / Q000254:growth & development*
D042501:Angiogenic Proteins; D006493:Heparin