title: Bone response to titanium implants coated with thin sputtered HA film subject to hydrothermal treatment and implanted in the canine mandible.
abstract: Hydroxyapatite (HA) was coated onto titanium implants using radio frequency magnetron sputtering. The HA films were crystallized in an autoclave tube using low temperature hydrothermal treatment. The average film thickness on the implant was 1.1 microm. HA-coated and pure-titanium implants were inserted into canine mandibles for up to 24 weeks. Forty-eight implants were placed in eight beagles. After 2, 4, 12 and 24 weeks, implants were retrieved and prepared for histological observation, and the HA film thickness was determined using energy-dispersive X-ray spectroscopy. Light microscopy revealed that, after two weeks, the bone response to the HA-coated implants was much better than to the pure titanium implants, and osteoblasts were observed at the bone-implant interface. After four weeks, the screw threads of the HA-coated implants were almost completely covered with bone. The HA film thickness rapidly decreased up to four weeks of implantation, then gently decreased, reaching 0.40+/-0.03 microm at the upper region of the implant after 12 weeks. That indicates that about 80% of the HA film had dissolved after 12 weeks of implantation. The rate of decrease in the HA film thickness was greater with increasing implant depth.
authors.affiliation: Frontier Research and Development Center, Tokyo Denki University, Ishizaka, Hatoyama, Hiki, Saitama 350-0394, Japan. ozeki@frontier.f.dendai.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ozeki
authors.forename: Y
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Fukui
authors.forename: H
authors.initials: H
authors.lastname: Aoki
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D004285:Dogs; D017886:Durapatite / Q000737:chemistry*; D019544:Equipment Failure Analysis; D006358:Hot Temperature; D008334:Mandible / Q000473:pathology* / Q000601:surgery*; D008422:Materials Testing; D011474:Prosthesis Design; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D014867:Water; D017886:Durapatite; D014025:Titanium