title: Plasma cell dyscrasia with kappa light-chain crystals in proximal tubular cells: a histological, immunofluorescent, and ultrastructural study.
abstract: This is a case report of a 56-year-old man with plasma cell dyscrasia who presented with proximal tubulopathy manifested as kappa light-chain crystal deposition in the proximal convoluted tubular cells. This was associated with mild cellular damage. The crystals were seen as negative images with the hematoxylin-eosin and periodic acid-Schiff (PAS) stains. They were identified as kappa light-chains by immunofluorescent imaging and confirmed by immunoelectron microscopy. Ultrastructurally, the crystals appear to be located within lysosomes. No deposits of light-chains were seen elsewhere in the kidney biopsy.
authors.affiliation: Department of Pathology, New York University Medical Center, New York, New York, USA.
authors.forename: Guoping
authors.initials: G
authors.lastname: Cai
authors.forename: Gurdip S
authors.initials: GS
authors.lastname: Sidhu
authors.forename: Rosemary
authors.initials: R
authors.lastname: Wieczorek
authors.forename: Xin
authors.initials: X
authors.lastname: Gu
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Herrera
authors.forename: Olcay
authors.initials: O
authors.lastname: Cubukcu-Dimopulo
authors.forename: Thomas
authors.initials: T
authors.lastname: Kahn
mesh_terms: D003460:Crystallization; D005455:Fluorescent Antibody Technique; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000737:chemistry / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D010265:Paraproteinemias / Q000378:metabolism* / Q000473:pathology*
chemical_list: D007145:Immunoglobulin kappa-Chains