Major metabolites of zolpidem: expeditious synthesis and mass spectra.
An expeditious route to the two major metabolites of Zolpidem-and readily applicable to the synthesis of the drug-was established via a cyclization reaction between a 2-aminopyridine and a suitable alpha-bromoacetophenone. The structures of the target compounds were confirmed from a 2D (1)H-(15)N NMR correlation. Their mass spectra contribute to a reliable toxicological identification of the drug in the case of drug-facilitated crimes.
Klupsch
Frédérique
F
Institut de Chimie Pharmaceutique Albert Lespagnol, EA 2692, Université de Lille 2, 3 rue du Professeur J. Laquesse, BP 83, 59006 Lille, France.
Houssin
Raymond
R
Humbert
Luc
L
Imbenotte
Michel
M
Hénichart
Jean-Pierre
JP
Lhermitte
Michel
M
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D013058:Mass Spectrometry / Q000379:methods*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D000077334:Zolpidem
D011725:Pyridines; D000077334:Zolpidem