Anti-donor DR103 Immunization in a DRB1*0101 kidney allograft recipient.
Posttransplant appearance of donor-specific anti-HLA antibodies is correlated with poor graft survival. Herein, we have provided evidence that an HLA-DRB1*0101 kidney allograft recipent developed anti-DR103 antibody after receiving a transplant from a HLA-DRB1*0103 cadaveric donor, resulting in graft loss. HLA-DRB1*0103 is a rare allele in Caucasian populations. It differs from DRB1*0101 only by three amino-acid substitutions and may play a central role in allorecognition. Nevertheless, our data showed that it induced alloimmunization in a DRB1*0101 recipient. Therefore, this new possibility of immunization must be taken into account before transplantation as well as after grafting.
Hajji
K
K
Department of Nephrology-Intensive Care-Transplantation, Centre Hospitalier Universitaire, Hôpital du Bocage, 1 boulevard de Lattre de Tassigny, 21000 Dijon, France.
Guignier
F
F
Tanter
Y
Y
Rifle
G
G
Mousson
C
C
D000906:Antibodies / Q000097:blood; D002102:Cadaver; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology*; D015798:HLA-DR1 Antigen / Q000276:immunology*; D059811:HLA-DRB1 Chains; D006801:Humans; D007114:Immunization; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology*; D008875:Middle Aged; D014184:Transplantation, Homologous / Q000276:immunology
D000906:Antibodies; D006680:HLA Antigens; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; C100845:HLA-DR103 antigen; D059811:HLA-DRB1 Chains