Drug-induced phospholipidosis.
Drug-induced phospholipidosis is characterized by intracellular accumulation of phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of the lysosome. Organs affected by phospholipidosis exhibit inflammatory reactions and histopathological changes. Despite significant advances in the understanding of drug-altered lipid metabolism, the relationship between impaired phospholipid metabolism and drug-induced toxicity remains enigmatic. Here we review molecular features of inheritable lysosomal storage disorders as a molecular mimicry of drug-induced phospholipidosis for an improved understanding of adverse drug reaction.
Anderson
Nora
N
Medical School of Hannover, Center for Pharmacology and Toxicology, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Borlak
Jürgen
J
D000818:Animals; D006801:Humans; D008064:Lipidoses / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology*; D008247:Lysosomes / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*
D010743:Phospholipids