Association of a single dose of gonadotropin-releasing hormone antagonist with nitric oxide and embryo quality in in vitro fertilization cycles.
The patients undertaking a single-dose protocol for GnRH antagonist were associated with elevated serum and follicular levels of nitric oxide (NO) and decreased embryo quality scores compared with those who underwent the long protocol for GnRH agonist. The relatively poor embryo quality may be NO related instead of Fas related.
Lee
Tsung-Hsien
TH
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Wu
Ming-Yih
MY
Chen
Hsin-Fu
HF
Chen
Shee-Uan
SU
Ho
Hong-Nerng
HN
Yang
Yu-Shih
YS
D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D006727:Hormone Antagonists; D009569:Nitric Oxide; D007987:Gonadotropin-Releasing Hormone