A/G heterozygote of the A-3826G polymorphism in the UCP-1 gene has higher BMI than A/A and G/G homozygote in young Japanese males.
UCP-1 is suggested to have important roles for thermogenesis and energy expenditure. To elucidate whether the A-3826G polymorphism that is located in the 5' flanking region of the UCP-1 gene has roles in healthy young people, the polymorphism was genotyped among 251 young Japanese men whose mean age is 22.7 years old. We analyzed relationship between the A-3826G polymorphism and body mass index (BMI) or six biochemical parameters, serum concentration of total cholesterol (TC), high density lipoprotein (HDL) cholesterol, triglyceride (TG), asparatate aminotransferase (AST), alanine aminotransferase (ALT), fasting plasma glucose. The genotype frequencies were observed at the frequencies of 24.3% for AA, 48.2% for AG and 27.5% for GG, respectively. When BMI and the biochemical parameters were compared by ANOVA among individuals with each genotype, the statistical difference was observed only for BMI (P=0.016). Bonferroni's test demonstrated that the men with the AG genotype have higher BMI than those with the AA genotype (22.4+/-2.8 vs. 21.4+/-2.2) (P=0.04). The individuals with the AG genotype also showed trend to have higher BMI than those with the GG, although the difference was not statistically apparent (22.4+/-2.8 vs. 21.5+/-2.3) (P=0.07). Our results indicated that the young healthy Japanese men with the AG heterozygote showed higher BMI than those with other genotypes.
Nakano
Takuro
T
Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School.
Shinka
Toshikatsu
T
Sei
Masako
M
Sato
Yoichi
Y
Umeno
Mayumi
M
Sakamoto
Kozue
K
Nomura
Isoko
I
Nakahori
Yutaka
Y
D000225:Adenine / Q000032:analysis; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001823:Body Composition / Q000235:genetics; D015992:Body Mass Index; D004247:DNA / Q000032:analysis / Q000235:genetics; D005838:Genotype; D006147:Guanine / Q000032:analysis; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D007564:Japan; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics; D011110:Polymorphism, Genetic; D000071256:Uncoupling Protein 1
D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1; D006147:Guanine; D004247:DNA; D000225:Adenine