title: A pilot study of facial, cranial and brain MRI morphometry in men with schizophrenia: part 2.
abstract: This pilot study applies a new 3D morphometric MR method to test the hypothesis that men with schizophrenia (vs. controls) have deviant facial shapes and landmark relations in cranio/facial/brain (CFB) regions. This constitutes Part 2 of paired articles in this issue of Psychiatry Research: Neuroimaging, in which Part 1 presents the new method in detail. MRI coordinates from CFB landmarks of 23 patients and 15 controls were identified and then aligned with the Procrustes model, leaving shape as the only unit-less geometrical information. Men with schizophrenia had significantly longer mid- and lower-facial heights, and greater lower (left) facial depth, with a tendency toward rotation along the facial midline. This supports findings from earlier anthropometric and 3D studies of the "exterior" (face). In contrast, none of the patient-control differences for the new "interior" (cranial-brain) distances reached statistical significance. These results need to be retested on a larger sample of both sexes.
authors.affiliation: Unit of Psychiatric Epidemiology, Barngatan 2, University Hospital, Lund University, S-221 85, Lund, Sweden. Karin.Henriksson@med.lu.se
authors.forename: Karin Maria
authors.initials: KM
authors.lastname: Henriksson
authors.forename: Karin
authors.initials: K
authors.lastname: Wickstrom
authors.forename: Nils
authors.initials: N
authors.lastname: Maltesson
authors.forename: Anders
authors.initials: A
authors.lastname: Ericsson
authors.forename: Johan
authors.initials: J
authors.lastname: Karlsson
authors.forename: Finn
authors.initials: F
authors.lastname: Lindgren
authors.forename: Kalle
authors.initials: K
authors.lastname: Astrom
authors.forename: Thomas Farrell
authors.initials: TF
authors.lastname: McNeil
authors.forename: Ingrid
authors.initials: I
authors.lastname: Agartz
mesh_terms: D000886:Anthropometry; D001921:Brain / Q000033:anatomy & histology*; D005145:Face / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010865:Pilot Projects; D012559:Schizophrenia / Q000175:diagnosis*; D012886:Skull / Q000033:anatomy & histology*