The MLL partial tandem duplication in acute myeloid leukaemia.
Mixed lineage leukaemia gene-partial tandem duplications (MLL-PTD) characterise acute myeloid leukaemia (AML) with trisomy 11 and AML with a normal karyotype. MLL-PTD confer a worse prognosis with shortened overall and event free survival in childhood and adult AML. In spite of these clinical observations, the leukaemogenic mechanism has, so far, not been determined. This review summarises clinical studies on MLL-PTD positive AML and recent experimental findings on the putative leukaemogenic role of MLL-PTD.
Basecke
Jorg
J
Division of Haematology and Oncology, University of Goettingen, Goettingen, Germany. jbaesec@gwdg.de
Whelan
Jarrett T
JT
Griesinger
Frank
F
Bertrand
Fred E
FE
D000208:Acute Disease; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D020440:Gene Duplication; D020022:Genetic Predisposition to Disease; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D011379:Prognosis; D020080:Tandem Repeat Sequences; D014314:Trisomy
D004273:DNA, Neoplasm; C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase