title: 'Your true and proper gender': the Barr body as a good enough science of sex.
abstract: In the late 1940s, a microanatomist from London Ontario, Murray Barr, discovered a mark of sex chromosome status in bodily tissues, what came to be known as the 'Barr body'. This discovery offered an important diagnostic technology to the burgeoning clinical science community engaged with the medical interpretation and management of sexual anomalies. It seemed to offer a way to identify the true, underlying sex in those whose bodies or lives were sexually anomalous (intersexuals, homosexuals and transsexuals). The hypothesis that allowed the Barr body to stand in for 'chromosomal' or 'genetic' sex was provisional, but it supported the expectation that genetic information established one's primary identity, and the conviction that the animal world could be neatly divided into two, and only two, sexes. Ultimately, this provisional hypothesis, and its status as an unambiguous arbiter of true sex, was overturned. But during much of the 1950s, Barr's thesis about the identity of the Barr body was consistent with a coherent set of theories and evidence explaining sexual development and sexual pathology. Though provisional, the scientific status of the sex chromatin within this system of knowledge was good enough to support a flourishing research enterprise in the clinical sciences.
authors.affiliation: Department of Clinical Epidemiology & Biostatistics, Centre for Health Economics and Policy Analysis, McMaster University, Health Science Centre 3H1A, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada. millerf@mcmaster.ca
authors.forename: Fiona Alice
authors.initials: FA
authors.lastname: Miller
mesh_terms: D000818:Animals; D012734:Disorders of Sex Development / Q000235:genetics*; D005260:Female; D036281:Genetic Research; D006059:Gonadal Dysgenesis / Q000235:genetics*; D006716:Homosexuality; D006801:Humans; D008297:Male; D012728:Sex Chromatin / Q000235:genetics*; D012730:Sex Chromosomes; D019849:Sex Determination Processes; D014189:Transsexualism; D014190:Transvestism