title: Changes of clotting factors (7, 9 and 10) and hepatocyte growth factor in patients with thrombotic microangiopathy after bone marrow transplantation.
abstract: To investigate risk factors for thrombotic microangiopathy (TMA) after bone marrow transplantation (BMT), the levels of three clotting factors (7, 9 and 10) and hepatocyte growth factor (HGF) were measured. Among 46 consecutive patients who underwent BMT, six developed TMA and 40 did not. The levels of the clotting factors and HGF did not differ significantly between the six patients with TMA and the 40 patients without it. In two patients who developed TMA during the earlyperiod after BMT, however, the levels of the three clotting factors were significantly decreased even before BMT, along with a significant increase of HGF. These findings suggest that patients with severe hepatic dysfunction before BMT, especially those with impaired protein synthesis, had an increased risk of developing TMA soon after BMT. It was also suggested that measurement of clotting factors (7, 9 and 10) and HGF may be useful to predict the occurrence of TMA in the early period after BMT.
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. htakatsu@hyo-med.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takatsuka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Kaori
authors.initials: K
authors.lastname: Nomura
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Okikawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wakae
authors.forename: Akinari
authors.initials: A
authors.lastname: Toda
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Itoi
authors.forename: Masaya
authors.initials: M
authors.lastname: Okada
authors.forename: Mahito
authors.initials: M
authors.lastname: Misawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hara
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D005164:Factor IX / Q000032:analysis*; D005167:Factor VII / Q000032:analysis*; D005170:Factor X / Q000032:analysis*; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism; D008297:Male; D011183:Postoperative Complications; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood* / Q000209:etiology
chemical_list: D017228:Hepatocyte Growth Factor; D005167:Factor VII; D005164:Factor IX; D005170:Factor X