Chemical technologies for probing glycans.
Glycans are central to many biological processes, but efforts to define their functions at the molecular level have been frustrated by a lack of suitable technologies. Here we highlight chemical tools that are beginning to address this need.
Prescher
Jennifer A
JA
Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
Bertozzi
Carolyn R
CR
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism; D006031:Glycosylation; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D049452:Green Fluorescent Proteins; D008969:Molecular Sequence Data; D019920:Photoaffinity Labels; D040081:Protein Array Analysis; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D040901:Proteomics; D014415:Tunicamycin / Q000494:pharmacology
D004791:Enzyme Inhibitors; D006023:Glycoproteins; D019920:Photoaffinity Labels; D014415:Tunicamycin; D049452:Green Fluorescent Proteins; D016695:Glycosyltransferases