No association between genetic variants at the GRIN1 gene and bipolar disorder in a German sample.
Disturbed glutamatergic neurotransmission has been implicated in the pathogenesis of schizophrenia and bipolar disorder, with the N-methy-D-aspartate receptors being in the focus of research. The NR1 subunit, which is encoded by the gene GRIN1, plays a key role in the functionality of N-methy-D-aspartate receptors. We tested the association between GRIN1 and bipolar disorder in a sample of German descent, consisting of 306 bipolar disorder patients and 319 population-based controls. No significant association was found. In accordance with our recent findings, we hypothesized that restricting case definition to individuals with a history of persecutory delusions might clarify the relationship between bipolar disorder and GRIN1. This stratified analysis did not yield any significant association either. Our results do not support an association of the GRIN1 gene with bipolar disorder in the German population.
Georgi
Alexander
A
Central Institute of Mental Health, Mannheim, Germany.
Jamra
Rami A
RA
Schumacher
Johannes
J
Becker
Tim
T
Schmael
Christine
C
Deschner
Monika
M
Höfels
Susanne
S
Wulff
Maren
M
Schwarz
Markus
M
Klopp
Norman
N
Illig
Thomas
T
Propping
Peter
P
Cichon
Sven
S
Nöthen
Markus M
MM
Rietschel
Marcella
M
Schulze
Thomas G
TG
D001714:Bipolar Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D014644:Genetic Variation; D005858:Germany; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*
D002352:Carrier Proteins; C485668:GRIN1 protein, human; D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate