Fatty acid synthesis and elongation in yeast.
Fatty acids are essential compounds in the cell. Since the yeast Saccharomyces cerevisiae does not feed typically on fatty acids, cellular function and growth relies on endogenous synthesis. Since all cellular organelles are involved in--or dependent on--fatty acid synthesis, multiple levels of control may exist to ensure proper fatty acid composition and homeostasis. In this review, we summarize what is currently known about enzymes involved in cellular fatty acid synthesis and elongation, and discuss potential links between fatty acid metabolism, physiology and cellular regulation.
Tehlivets
Oksana
O
Institute of Molecular Biosciences, University of Graz, A8010 Graz, Austria.
Scheuringer
Kim
K
Kohlwein
Sepp D
SD
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D003067:Coenzymes / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
D003067:Coenzymes; D005227:Fatty Acids; D029701:Saccharomyces cerevisiae Proteins; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase