title: Age and gender dependence of human cardiac phosphorus metabolites determined by SLOOP 31P MR spectroscopy.
abstract: The aim of this study was to apply (31)P magnetic resonance spectroscopy (MRS) using spatial localization with optimal point spread function (SLOOP) to investigate possible age and gender dependencies of the energy metabolite concentrations in the human heart. Thirty healthy volunteers (18 males and 12 females, 21-67 years old, mean = 40.7 years) were examined with the use of (31)P-MRS on a 1.5 T scanner. Intra- and interobserver variability measures (determined in eight of the volunteers) were both 3.8% for phosphocreatine (PCr), and 4.7% and 8.3%, respectively, for adenosine triphosphate (ATP). High-energy phosphate (HEP) concentrations in mmol/kg wet weight were 9.7 +/- 2.4 (age < 40 years, N = 16) and 7.7 +/- 2.5 (age >or= 40 years, N = 14) for PCr, and 5.1 +/- 1.0 (age < 40 years) and 4.1 +/- 0.8 (age >or= 40 years) for ATP, respectively. Separated by gender, PCr concentrations of 9.2 +/- 2.4 (men, N = 18) and 8.0 +/- 2.8 (women, N = 12) and ATP concentrations of 4.9 +/- 1.0 (men) and 4.2 +/- 0.9 (women) were measured. A significant decrease of PCr and ATP was found for volunteers older than 40 years (P < 0.05), but the differences in metabolic concentrations between both sexes were not significant. In conclusion, age has a minor but still significant impact on cardiac energy metabolism, and no significant gender differences were detected.
authors.affiliation: Institut für Röntgendiagnostik, Universität Würzburg, Würzburg, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Köstler
authors.forename: Wilfried
authors.initials: W
authors.lastname: Landschütz
authors.forename: Sabrina
authors.initials: S
authors.lastname: Koeppe
authors.forename: Tobias
authors.initials: T
authors.lastname: Seyfarth
authors.forename: Claudia
authors.initials: C
authors.lastname: Lipke
authors.forename: Jörn
authors.initials: J
authors.lastname: Sandstede
authors.forename: Matthias
authors.initials: M
authors.lastname: Spindler
authors.forename: Markus
authors.initials: M
authors.lastname: von Kienlin
authors.forename: Dietbert
authors.initials: D
authors.lastname: Hahn
authors.forename: Meinrad
authors.initials: M
authors.lastname: Beer
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000328:Adult; D000367:Age Factors; D000368:Aged; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism*; D010759:Phosphorus Isotopes; D012737:Sex Factors; D018709:Statistics, Nonparametric
chemical_list: D010710:Phosphates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate