Observation of dynamic subdomains in red blood cells.
We quantify the nanoscale structure and low-frequency dynamics associated with live red blood cells. The membrane displacements are measured using quantitative phase images provided by Fourier phase microscopy, with an average path-length stability of 0.75 nm over 45 min. The results reveal the existence of dynamic, independent subdomains across the cells that fluctuate at various dominant frequencies.
Popescu
Gabriel
G
Badizadegan
Kamran
K
Dasari
Ramachandra R
RR
Feld
Michael S
MS
D002465:Cell Movement / Q000502:physiology; D048429:Cell Size; D002478:Cells, Cultured; D004910:Erythrocyte Membrane / Q000502:physiology* / Q000648:ultrastructure*; D004912:Erythrocytes / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007700:Kinetics; D008560:Membrane Fluidity / Q000502:physiology*; D021962:Membrane Microdomains / Q000502:physiology* / Q000648:ultrastructure*; D008858:Microscopy, Phase-Contrast / Q000379:methods*