title: Complete response of bony metastatic bladder urothelial cancer to neoadjuvant chemotherapy and cystectomy.
abstract: We report on a 38-year-old male diagnosed with biopsy-proven bladder urothelial carcinoma metastatic to the bone, who had a complete response to neoadjuvant chemotherapy consisting of carboplatin and gemcitabine. The final pathology of his radical cystoprostatectomy revealed no residual cancer. The patient continues to be without evidence of disease 2 years postoperatively. This case shows that neoadjuvant chemotherapy with nonstandard regimens can yield responses in patients with bone metastases.
authors.affiliation: Department of Urology, University of Iowa, Iowa City, IA 52242-1089, USA. fadi-joudi@uiowa.edu
authors.forename: Fadi N
authors.initials: FN
authors.lastname: Joudi
authors.forename: Laila
authors.initials: L
authors.lastname: Dahmoush
authors.forename: David M
authors.initials: DM
authors.lastname: Spector
authors.forename: Badrinath R
authors.initials: BR
authors.lastname: Konety
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D015653:Cystectomy; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery / Q000628:therapy*