Contraceptive effect of sperm-agglutinating factor isolated from Staphylococcus aureus in mouse.
OBJECTIVE
To investigate the contraceptive effect of sperm-agglutinating factor (SAF) isolated from Staphylococcus aureus in mouse.


METHODS
Experimental study performed with LACA mice obtained from the Central Animal House, Panjab University, Chandigarh, India.


METHODS
In vivo studies conducted in the Department of Microbiology, Panjab University, Chandigarh, India.


METHODS
Sixty female and 18 male mice were used for the studies.


METHODS
Mice sperm-S. aureus agglutination, scanning electron microscopy (SEM), in vivo studies in mice.


METHODS
Contraceptive efficacy of SAF.


RESULTS
S. aureus readily adhered to and agglutinated mouse spermatozoa. By SEM, S. aureus adherence was observed on sperm head as well as sperm tail. SAF was found to be causing 100% fertility inhibition in mouse with no effect on vaginal epithelium.


CONCLUSIONS
Sperm-agglutinating factor has been found to have a potential as a contraceptive agent.
Aggarwal
J
J
Department of Microbiology, Panjab University, Chandigarh, India.
Prabha
V
V
D000373:Agglutinins / Q000494:pharmacology*; D000818:Animals; D003271:Contraceptive Agents, Female / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D005831:Genital Diseases, Female / Q000139:chemically induced; D008297:Male; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D013073:Sperm Agglutination / Q000187:drug effects; D013089:Spermatocidal Agents / Q000009:adverse effects / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects*; D013211:Staphylococcus aureus; D018675:Toxicity Tests
D000373:Agglutinins; D003271:Contraceptive Agents, Female; D013089:Spermatocidal Agents