title: The PediPump: development status of a new pediatric ventricular assist device: update II.
abstract: The PediPump is a new ventricular assist device with a hydraulic output range designed for children from newborn infants to adolescents. The design is based on a mixed-flow rotary pump; the rotating assembly consists of a front impeller, front and rear radial magnetic bearings, and a central motor magnet. Two different implantable pumps were designed initially: an intravascular pump measuring 7 x 75 mm and an extravascular pump measuring 14 x 85 mm. Current prototypes are substantially smaller: The current intravascular version measures 4.5 x 55 mm, whereas the current extravascular version measures 11 x 70 mm. Both devices provide pressure and flows capable of supporting adults, far exceeding the initially defined physiologic requirements for children weighing 2 to 25 kg. This basic pump design may be used in acute or chronic clinical settings to provide right ventricular, left ventricular, or biventricular support. There are three objectives for the PediPump development program: 1) determination of basic engineering requirements for hardware and control logic including design analysis for system sizing, evaluation of control concepts, and bench testing of prototypes; 2) performance of preclinical anatomic fitting studies using CT-based 3D modeling; and 3) animal studies to provide characterization and reliability testing of the device.
authors.affiliation: Department of Pediatric and Congenital Heart Surgery, Children's Hospital, Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Duncan
authors.forename: David T
authors.initials: DT
authors.lastname: Dudzinski
authors.forename: Lei
authors.initials: L
authors.lastname: Gu
authors.forename: Nicole
authors.initials: N
authors.lastname: Mielke
authors.forename: Angela M
authors.initials: AM
authors.lastname: Noecker
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kopcak
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: Faruk
authors.initials: F
authors.lastname: Cingoz
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: William A
authors.initials: WA
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D001698:Biomedical Engineering; D002648:Child; D002675:Child, Preschool; D006353:Heart-Assist Devices; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011474:Prosthesis Design; D017755:Prosthesis Fitting