title: High-risk melanoma with nodal involvement in a young woman.
abstract: BACKGROUND
  An 18-year-old female presented to her General Practitioner with a bleeding mole on her back. The mole had been present since childhood but had started to bleed in the past month. She was otherwise asymptomatic with no relevant previous medical history. Physical examination revealed a 1.5 cm 1.7 cm pigmented lesion on the left aspect of the patient's upper back. There was no palpable lymphadenopathy.
  
  
  METHODS
  Physical examination, excision biopsy, sentinel lymph node biopsy, CT scan of chest, abdomen and pelvis.
  
  
  METHODS
  Stage IIIB (T3bN2aM0) focally ulcerated, nodular malignant melanoma (Breslow depth 2.5 mm, Clark's level IV).
  
  
  RESULTS
  Wide re-excision, completion dissection of the left axillary lymph node, adjuvant high-dose interferon with maintenance interferon.
authors.affiliation: Cancer Research UK, Department of Medical Oncology, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK. omar.khan@cancer.org.uk
authors.forename: Omar
authors.initials: O
authors.lastname: Khan
authors.forename: Mark
authors.initials: M
authors.lastname: Middleton
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008545:Melanoma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D011994:Recombinant Proteins; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins