title: Exploring candidate genes for human brain diseases from a brain-specific gene network.
abstract: It is believed that large numbers of genes are involved in common human brain diseases. Here, we propose a novel computational strategy for simultaneously identifying multiple candidate genes for genetic human brain diseases from a brain-specific gene network-level perspective. By integrating diverse genomic and proteomic datasets based on Bayesian statistical model, we built a large-scale human brain-specific gene network. Based on this network and minor prior knowledge of a specific brain disease, we can effectively identify multiple candidate genes for this disease. When four known Alzheimer's disease genes were used as the prior knowledge, among the top 46 high-scoring genes that we have found, 37 were previously reported to be associated with Alzheimer's disease. And the higher score a gene has, the more likely this gene is a disease-related one. The results suggest that the proposed method is effective, convenient, and applicable in the future genetic studies.
authors.affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.forename: Songde
authors.initials: S
authors.lastname: Ma
authors.forename: Huizhi
authors.initials: H
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Xingpeng
authors.initials: X
authors.lastname: Jiang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003198:Computer Simulation; D030562:Databases, Protein; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D052066:N-Ethylmaleimide-Sensitive Proteins / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020543:Proteome; D052066:N-Ethylmaleimide-Sensitive Proteins