title: ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia.
abstract: The association of endothelin 1 (ET-1) and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphisms (G5665T and T8002C, VNTR and T-786C respectively) with the occurrence of acute chest syndrome and painful vaso-occlusive crises was evaluated in homozygous SS children. This retrospective study reveals that ET-1 T8002 and ecNOS C-786 alleles are associated with, respectively, an increased and a decreased risk of acute chest syndrome.
authors.forename: Vicky
authors.initials: V
authors.lastname: Chaar
authors.forename: Vanessa
authors.initials: V
authors.lastname: Tarer
authors.forename: Maryse
authors.initials: M
authors.lastname: Etienne-Julan
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Diara
authors.forename: Jacques
authors.initials: J
authors.lastname: Elion
authors.forename: Marc
authors.initials: M
authors.lastname: Romana
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics*; D002637:Chest Pain / Q000235:genetics; D002648:Child; D019332:Endothelin-1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D010146:Pain; D011110:Polymorphism, Genetic; D014652:Vascular Diseases
chemical_list: D019332:Endothelin-1; D052250:Nitric Oxide Synthase Type III