Anxiolytic effect of noscapine in mice.
The anxiety-related effects of noscapine were investigated using male Balb-c mice. Since noscapine-induced locomotion may alter the animals' activity level in the dark-light model, the anxiety-related effects of noscapine were studied at doses with no effect on locomotion (0.1, 0.2, 0.3, 0.4, 0.5, 0.8, 1, 1.5 and 2 mg/kg). The parameter measured in dark-light model was the time spent in lit compartment. Intraperitoneal administration of noscapine (0.1-0.5 mg/kg) did not produce a significant effect on the time spent in the light, whereas higher doses (0.8, 1, 1.5 and 2 mg/kg) increased it significantly, implying an anxiolytic effect.
Khodarahmi
Parvin
P
Department of Biology, Islamic Azad University, Parand Branch, Tehran, Iran.
Rostami
Parvin
P
Rashidi
Armin
A
Khodarahmi
Iman
I
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003624:Darkness; D004305:Dose-Response Relationship, Drug; D008027:Light; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009665:Noscapine / Q000494:pharmacology*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D009665:Noscapine