Natural history and management of flat and polypoid dysplasia in inflammatory bowel disease.
Dysplasia can be a marker that cancer is already present or is coming in the near future. Hence, Physicians should not be cavalier in approach to finding it or in approach after it is found, whether it is in flat mucosa or raised mucosa. Low-grade dysplasia should garner similar respect to high-grade dysplasia, if for no other reason than the difficulty that expert pathologists have with distinguishing low-grade dysplasia from high-grade dysplasia. There is no sure way to reduce the likelihood that dysplasia will arise in UC. Some investigators have promoted the use of 5-ASA. This topic is covered in greater detail elsewhere in this issue (see article by Rubin and Kavitt elsewhere in this issue); however, there is no definitive evidence that 5-ASA can reduce cancer incidence.
Bernstein
Charles N
CN
Department of Internal Medicine and Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, 804F-715 McDermot Avenue, Winnipeg, Manitoba, R3E 3P4, Canada. cbernst@cc.umanitoba.ca
D003093:Colitis, Ulcerative / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D003111:Colonic Polyps / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D018450:Disease Progression; D006801:Humans; D011159:Population Surveillance; D011230:Precancerous Conditions / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery