Loading and release of ibuprofen in multi- and monofilament surgical sutures.
The preparation of mono- and multifilament sutures incorporating ibuprofen as an anti-inflammatory agent is considered. Poly(p-dioxanone) monofilament samples can be loaded by a molecular diffusion process using a swelling agent such as dichloromethane. The mechanical properties have been measured and have not shown a significant change for the ibuprofen loaded samples in knot tensile assays. The kinetics of both the loading process and the release in a Sörensen's medium at 37 degrees C have been investigated. Diffusion coefficients have also been estimated from film and slab poly(p-dioxanone) samples containing ibuprofen and their release behavior compared to that shown by monofilaments. Release from a coating copolymer based on lactide, epsilon-caprolactone and trimethylene carbonate (PLA/PCA/PTMC 10/60/30) has also been studied. This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred.
Zurita
Raül
R
Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, E-08028, Barcelona, Spain.
Puiggalí
Jordi
J
Rodríguez-Galán
Alfonso
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004146:Dioxanes / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods; D007052:Ibuprofen / Q000493:pharmacokinetics*; D007783:Lactones / Q000494:pharmacology; D008422:Materials Testing / Q000379:methods; D008954:Models, Biological; D008962:Models, Theoretical; D011091:Polyesters / Q000494:pharmacology; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D013536:Suture Techniques; D013537:Sutures; D013718:Tensile Strength / Q000187:drug effects; D013784:Textiles / Q000032:analysis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004146:Dioxanes; D007783:Lactones; D011091:Polyesters; D011108:Polymers; C410438:TMC-ECL copolymer; C079733:poly-4-dioxan-2-one; C062968:lactide-caprolactone copolymer; C059814:4-dioxanone; D007052:Ibuprofen