Irgarol inhibits the synthesis of ATP in mitochondria from rat liver.
The interactions of Irgarol with rat liver mithocondrial have been investigated. The results indicate that Irgarol inhibits the ATP synthesis. The analysis of the various steps involved in the ATP synthesis suggests that the inhibition is due to the opening of small-size pores.
Bragadin
Marcantonio
M
Dipartimento di Scienze Ambientali, Università di Venezia, DD 2137, 30123 Venice, Italy. bragadin@unive.it
Cima
Francesca
F
Ballarin
Loriano
L
Manente
Sabrina
S
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000187:drug effects; D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone / Q000494:pharmacology; D019069:Cell Respiration / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D010539:Permeability; D011522:Protons; D051381:Rats; D017208:Rats, Wistar; D014227:Triazines / Q000008:administration & dosage / Q000009:adverse effects*; D014475:Uncoupling Agents / Q000494:pharmacology
D004791:Enzyme Inhibitors; D009840:Oligomycins; D011522:Protons; D014227:Triazines; D014475:Uncoupling Agents; C103341:irgarol 1051; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases