title: Decreased protein S activity is related to the disease activity of Behcet's disease.
abstract: We wanted to see whether the active inflammation in Behcet's disease (BD) can cause a thrombotic disorder by decreasing the protein S (PS) activity, and we evaluated the relationship between the decreased PS activity and the disease activity of BD. We included 122 patients with BD whose PS activity levels were measured. In 51 patients, the PS activity was measured again when there were changes in the number of items of "The Behcet's Disease Current Activity Form (BDCAF)". The thrombosis rate was 2.5% (3/122), and the PS activity was low in all three of the patients with thrombosis. The incidence of low PS activity in the total 122 BD patients was 27% (33/122). The incidence of the low PS activity in the active BD patients was 33.7% (31/92), and this was significantly more frequent than in the inactive BD patients, (6.7%, 2/30) (chi(2)-test, P value = 0.0038). The decrease of PS activity had good correlation with the increase of the number of BDCAF items (r = -0.351, P value = 0.012). The PS activity decrease is related to the BD activity. The low PS activity can be the risk factor for thrombotic disorder and also the activity marker for BD and other inflammatory diseases.
authors.affiliation: Department of Internal Medicine, College of Medicine, Inha University, Inchon, 400-711, South Korea.
authors.forename: Seong Ryul
authors.initials: SR
authors.lastname: Kwon
authors.forename: Mie Jin
authors.initials: MJ
authors.lastname: Lim
authors.forename: Shin Goo
authors.initials: SG
authors.lastname: Park
authors.forename: Yeon Sook
authors.initials: YS
authors.lastname: Moon
authors.forename: Won
authors.initials: W
authors.lastname: Park
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood* / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017293:Protein S / Q000378:metabolism*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013927:Thrombosis / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D017293:Protein S