Investigation of reactivity and selectivity of DNA-alkylating duocarmycin analogues by high-resolution mass spectrometry.
Tietze
Lutz F
LF
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany. ltietze@gwdg.de
Krewer
Birgit
B
Frauendorf
Holm
H
Major
Felix
F
Schuberth
Ingrid
I
D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D053938:DNA Fragmentation; D000080890:Duocarmycins; D004591:Electrophoresis, Polyacrylamide Gel; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011355:Prodrugs / Q000138:chemical synthesis; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
D000477:Alkylating Agents; D000080890:Duocarmycins; D007202:Indicators and Reagents; D007211:Indoles; D011355:Prodrugs; D011758:Pyrroles; C066098:duocarmycin SA; D004247:DNA