title: Effects of raloxifene on platelet functions in patients with postmenopausal osteoporosis.
abstract: Many studies have addressed the effects of estrogenic compounds on platelet function. Raloxifene is a selective estrogen receptor modulator (SERM), which is currently used for the treatment of postmenopausal osteoporosis. At present, there are no clinical data about the effects of raloxifene on platelet function. The purpose of this study was to determine if raloxifene at therapeutic doses affects platelet function in patients with postmenopausal osteoporosis. The effects of raloxifene on platelet function were investigated using a commercial platelet function analyzer (PFA-100) with collagen epinephrine and collagen adenosine 5'-diphosphate (ADP) cartridges. We studied platelet function of 30 patients with postmenopausal osteoporosis before and 15 days after initiation of raloxifene 60 mg/daily. Closure times did not differ significantly between samples obtained before (117.8 +/- 20.5 s) and after raloxifene therapy (106.5 +/- 25.4 s) in collagen/epinephrine cartridges (P > 0.05). There was also no statistically significant difference in mean closure times with collagen/ADP cartridges at baseline (86.2 +/- 18.5 s) and after raloxifene therapy (84.4 +/- 13.8 s) (P > 0.05). Platelet counts (278.3 +/- 72.9 vs. 262.4 +/- 56.7 109/L, P > 0.05) and mean platelet volumes (8.9 +/- 1 vs. 9.1 +/- 1 fL, P > 0.05) were not different before and after raloxifene therapy. Although estrogen related compounds do affect platelet function, there is suggestive data in our study that raloxifene in therapeutic dose exhibit no effect on platelet function in patients with postmenopausal osteoporosis.
authors.affiliation: Faculty of Medicine, Department of Endocrinology and Metabolism, Baskent University, Ankara, Turkey.
authors.forename: Derun Taner
authors.initials: DT
authors.lastname: Ertugrul
authors.forename: Alptekin
authors.initials: A
authors.lastname: Gürsoy
authors.forename: Muammer
authors.initials: M
authors.lastname: Yücel
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Asli Dogruk
authors.initials: AD
authors.lastname: Unal
authors.forename: Baris
authors.initials: B
authors.lastname: Pamuk
authors.forename: Zehra
authors.initials: Z
authors.lastname: Berberoglu
authors.forename: Semra
authors.initials: S
authors.lastname: Aytürk
authors.forename: Neslihan Bascil
authors.initials: NB
authors.lastname: Tutuncu
authors.forename: Nilgun Guvener
authors.initials: NG
authors.lastname: Demirag
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000188:drug therapy; D010979:Platelet Function Tests; D017698:Postmenopause / Q000097:blood / Q000187:drug effects; D011446:Prospective Studies; D020849:Raloxifene Hydrochloride / Q000009:adverse effects*; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects*; D018709:Statistics, Nonparametric
chemical_list: D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride