title: Sleep restriction increases blood neutrophils, total cholesterol and low density lipoprotein cholesterol in postmenopausal women: A preliminary study.
abstract: OBJECTIVE
  This study examines the effects of sleep restricted to 4h for three consecutive nights on blood parameters known to be associated with cardiovascular risk in healthy postmenopausal women.
  
  
  METHODS
  Ten healthy postmenopausal women aged 55-65 years treated with hormonal replacement therapy (HT) were included in the study. After one baseline night, three nights of sleep restricted to 4h were performed and were followed by one recovery night of 8h. Blood samplings were performed after the baseline night and after the third night of sleep restriction.
  
  
  RESULTS
  A significant increase in white blood cells (WBC), monocytes, neutrophils, total cholesterol, and low density lipoprotein cholesterol (LDL-c) was observed after the third night of sleep restriction.
  
  
  CONCLUSIONS
  Sleep restriction to 4h of sleep for three consecutive nights affected two factors associated with cardiovascular risk in healthy postmenopausal women treated with HT.
authors.affiliation: Sleep Laboratory, CHU de Charleroi, Vésale Hospital, Free University of Brussels, Rue de Gozée 706, 6110 Montigny-le-Tilleul, Belgium. myriam.kerkhofs@chu-charleroi.be
authors.forename: Myriam
authors.initials: M
authors.lastname: Kerkhofs
authors.forename: Karim Zouaoui
authors.initials: KZ
authors.lastname: Boudjeltia
authors.forename: Patricia
authors.initials: P
authors.lastname: Stenuit
authors.forename: Dany
authors.initials: D
authors.lastname: Brohée
authors.forename: Philippe
authors.initials: P
authors.lastname: Cauchie
authors.forename: Michel
authors.initials: M
authors.lastname: Vanhaeverbeek
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology; D002452:Cell Count; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D010865:Pilot Projects; D017698:Postmenopause / Q000097:blood*; D012307:Risk Factors; D012892:Sleep Deprivation / Q000097:blood*
chemical_list: D008078:Cholesterol, LDL; D002784:Cholesterol