title: Sildenafil reduces postoperative adhesion formation in a rat uterine horn model.
abstract: OBJECTIVE
  The purpose of this experimental study was to evaluate the effect of oral sildenafil on postoperative adhesion formation in rats.
  
  
  METHODS
  Thirty-two Wistar Albino rats were subjected to standardized lesion by cauterization of the uterine horn and abrasion of the adjacent parietal peritoneum. They were randomized to receive sildenafil at a daily dose of 15 mg/kg, 7.5mg/kg and 3.75 mg/kg or placebo. Sildenafil was administered by gavage 1h before the operation and daily for 5 days after the procedure. The extent and severity of adhesions were assessed on the 14th postoperative day.
  
  
  RESULTS
  The severity but not extent of adhesions in rats given 15 mg/kg sildenafil was significantly less when compared with the other groups (<0.001).
  
  
  CONCLUSIONS
  Sildenafil diminishes peritoneal adhesion formation in rat.
authors.affiliation: Erciyes University, School of Medicine, Department of Obstetrics and Gynecology, Gevher Neshibe Hospital, 38039 Kayseri, Turkey. cbatukan@erciyes.edu.tr
authors.forename: Cem
authors.initials: C
authors.lastname: Batukan
authors.forename: Mahmut T
authors.initials: MT
authors.lastname: Ozgun
authors.forename: Mustafa
authors.initials: M
authors.lastname: Basbug
authors.forename: Iptisam I
authors.initials: II
authors.lastname: Muderris
mesh_terms: D000818:Animals; D005260:Female; D007813:Laparotomy; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000068677:Sildenafil Citrate; D018709:Statistics, Nonparametric; D013450:Sulfones / Q000494:pharmacology*; D000267:Tissue Adhesions / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery*
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate