Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: opportunities and limitations.
This is a discussion of the following two papers in this special issue on adaptive designs: 'Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: General concepts' by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer, and 'Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: Applications and practical considerations' by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer.
Jenniso
Christopher
C
Department of Mathematical Sciences, University of Bath, Bath BA2 7AY, UK. cj@maths.bath.ac.uk
Turnbull
Bruce W
BW
D001699:Biometry; D017322:Clinical Trials, Phase II as Topic / Q000706:statistics & numerical data*; D017326:Clinical Trials, Phase III as Topic / Q000706:statistics & numerical data*; D023381:Endpoint Determination / Q000706:statistics & numerical data*; D015233:Models, Statistical; D018579:Patient Selection; D012107:Research Design / Q000706:statistics & numerical data*