Plasma adrenomedullin levels in patients with polycystic ovary syndrome.
OBJECTIVE
To evaluate adrenomedullin levels in patients with polycystic ovary syndrome (PCOS).


METHODS
Prospective study.


METHODS
Department of obstetrics and gynecology in a university hospital.


METHODS
Thirty-eight women with PCOS and 29 healthy control subjects were enrolled in the study.


METHODS
Plasma adrenomedullin, serum androstenedione, free T, T, DHEAS, SHBG, thyrotropin, PRL, FSH, LH, and E2 were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose:insulin ratio and 75-g glucose tolerance test for 2 hours.


METHODS
Plasma adrenomedullin levels and correlations among adrenomedullin and gonadotropins, female sex steroids, androgens, and insulin resistance.


RESULTS
There was no significant difference concerning plasma adrenomedullin concentrations between the groups. In patients with PCOS, fasting glucose, fasting insulin, body mass index, and free T were inversely correlated with the plasma adrenomedullin. Plasma adrenomedullin was significantly correlated with glucose:insulin ratio. After controlling for body mass index, there were no significant correlations between the above-mentioned parameters.


CONCLUSIONS
Adrenomedullin may play a role in regulating the insulin metabolism in patients with PCOS.
Ucar
Banu
B
Department of Obstetrics and Gynecology, Kirikkale University School of Medicine, Kirikkale, Turkey. banuucar@gmail.com
Noyan
Volkan
V
Caglayan
Osman
O
Yucel
Aykan
A
Sagsoz
Nevin
N
D000293:Adolescent; D053607:Adrenomedullin; D000328:Adult; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007333:Insulin Resistance; D010455:Peptides / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013223:Statistics as Topic
D010455:Peptides; D053607:Adrenomedullin