Polyester-based carborane-containing dendrons.
New carborane-containing dendrons based on a 2,2-bis(hydroxymethyl)propanoic acid scaffold have been prepared for applications in boron neutron capture therapy. A generation-2 carborane-containing dendron carrying 40 boron atoms was the highest generation synthetically available due to the steric crowding. The structure of this dendron has been simulated by molecular dynamics. A 10-carbon linker carrying a carboxylic group has been installed at the focal point of the dendron to distance the attachment point from the sterically hindered core.
Galie
Kristin M
KM
Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Mollard
Alexis
A
Zharov
Ilya
I
D001896:Boron Compounds / Q000737:chemistry*; D003198:Computer Simulation; D050091:Dendrimers / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011091:Polyesters / Q000737:chemistry*
D001896:Boron Compounds; D050091:Dendrimers; D011091:Polyesters