Role of hospital stay and antibiotic use on Pseudomonas aeruginosa gastrointestinal colonization in hospitalized patients.
The prospective cohort study presented here assessed the risk factors associated with Pseudomonas aeruginosa gastrointestinal colonization (PAGIC) in 933 patients hospitalized in five different wards in a French university hospital. A total of 195 patients were colonized. By logistic regression, hospitalization in an intensive care unit and length of hospital stay were independent risk factors. A significant association was observed between fluoroquinolone use and PAGIC caused by an ofloxacin-resistant strain (p < 0.0001), imipenem use and PAGIC caused by an imipenem-resistant strain (p < 0.0002) and ceftazidime use and PAGIC caused by a ceftazidime-resistant strain (p < 0.02). The ecological impact of antibiotic use is of great clinical relevance and clinicians should consider antimicrobial resistance in order to limit the development and dissemination of resistant microorganisms.
Lepelletier
D
D
Laboratoire de Bactériologie-Virologie et d'Hygiène, Institut de Biologie, Hôtel-Dieu, Place A. Ricordeau, 44093 Nantes, France. didier.lepelletier@chu-nantes.fr
Caroff
N
N
Riochet
D
D
Bizouarn
P
P
Bourdeau
A
A
Le Gallou
F
F
Espaze
E
E
Reynaud
A
A
Richet
H
H
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003428:Cross Infection / Q000382:microbiology*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000302:isolation & purification*; D012307:Risk Factors
D000900:Anti-Bacterial Agents