title: Adenovirus fulminant hepatic failure: disseminated adenovirus disease after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia.
abstract: Adenovirus is one of the major causes of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation for hematological malignancy. Fulminant hepatic failure is a rare manifestation of post-transplant complication with adenovirus. Extremely high mortality and aggressiveness of the clinical course have been posing clinical challenges for the diagnosis as well as for the treatment. Here, we report a case with disseminated adenovirus disease presenting with fulminant hepatic failure after bone marrow transplantation for acute lymphoblastic leukemia.
authors.affiliation: Department of Internal Medicine/Hematology, Shinshu University School of Medicine, Matsumoto, Nagano.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nakazawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ito
authors.forename: Hideki
authors.initials: H
authors.lastname: Makishima
authors.forename: Noriko
authors.initials: N
authors.lastname: Misawa
authors.forename: Wataru
authors.initials: W
authors.lastname: Okiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uehara
authors.forename: Eiko
authors.initials: E
authors.lastname: Hidaka
authors.forename: Kendo
authors.initials: K
authors.lastname: Kiyosawa
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Ishida
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications* / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000473:pathology; D017114:Liver Failure, Acute / Q000473:pathology / Q000821:virology*; D008854:Microscopy, Electron; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous