Opening the adaptive toolbox.
This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'A regulatory view on adaptive/flexible clinical trial design' by H. M. James Hung, Robert T. O'Neill, Sue-Jane Wang and John Lawrence; 'Confirmatory clinical trials with an adaptive design' by Armin Koch; and 'FDA's critical path initiative: A perspective on contributions of biostatistics' by Robert T. O'Neill.
Wittes
Janet
J
Statistics Collaborative, 1625 Massachusetts Ave., NW, Washington, DC 20036, USA. janet@statcollab.com
Lachenbruch
Peter A
PA
D001699:Biometry; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D017326:Clinical Trials, Phase III as Topic / Q000706:statistics & numerical data; D003627:Data Interpretation, Statistical; D012107:Research Design / Q000706:statistics & numerical data*