title: A randomized prospective evaluation of outcomes after total hip arthroplasty using cross-linked marathon and non-cross-linked Enduron polyethylene liners.
abstract: Cross-linked liners were introduced with the promise that they would substantially reduce polyethylene wear. In 1999, our institution initiated a prospective study to compare the outcome of total hip arthroplasty patients who were randomized to non-cross-linked Enduron liners with that of total hip arthroplasty patients who were randomized to Marathon polyethylene liners that had been cross-linked with 5 Mrad (50 kGy) of gamma-irradiation and heat-treated to eliminate free radicals. At a mean follow-up of 5.7 years, the clinical outcomes among the Marathon and Enduron liners were similar. However, the mean wear rate was 0.01 +/- 0.07 mm/y for the Marathon group, which represents a 95% reduction compared with the mean wear rate of 0.19 +/- 0.12 mm/y for the Enduron group. In addition, the incidence of osteolysis was lower in the Marathon group.
authors.affiliation: Anderson Orthopedic Research Institute, Alexandria, Virginia, USA.
authors.forename: C Anderson
authors.initials: CA
authors.lastname: Engh
authors.forename: Adam S
authors.initials: AS
authors.lastname: Stepniewski
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Ginn
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Beykirch
authors.forename: Christi J
authors.initials: CJ
authors.lastname: Sychterz-Terefenko
authors.forename: Robert H
authors.initials: RH
authors.lastname: Hopper
authors.forename: Charles A
authors.initials: CA
authors.lastname: Engh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation* / Q000379:methods*; D001672:Biocompatible Materials / Q000737:chemistry; D005260:Female; D005609:Free Radicals; D005720:Gamma Rays; D006801:Humans; D007592:Joint Diseases / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D020959:Polyethylene / Q000737:chemistry; D011446:Prospective Studies; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D005609:Free Radicals; D020959:Polyethylene