ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia.
The association of endothelin 1 (ET-1) and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphisms (G5665T and T8002C, VNTR and T-786C respectively) with the occurrence of acute chest syndrome and painful vaso-occlusive crises was evaluated in homozygous SS children. This retrospective study reveals that ET-1 T8002 and ecNOS C-786 alleles are associated with, respectively, an increased and a decreased risk of acute chest syndrome.
Chaar
Vicky
V
Tarer
Vanessa
V
Etienne-Julan
Maryse
M
Diara
Jean Pierre
JP
Elion
Jacques
J
Romana
Marc
M
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics*; D002637:Chest Pain / Q000235:genetics; D002648:Child; D019332:Endothelin-1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D010146:Pain; D011110:Polymorphism, Genetic; D014652:Vascular Diseases
D019332:Endothelin-1; D052250:Nitric Oxide Synthase Type III