title: Gene therapy for pulmonary diseases.
abstract: Gene therapy has not yet met the high expectations of "the early days." However, it is a promising new treatment for lung diseases. Not only single gene disorders such as CF are potential candidates for gene therapy, but also cancer and chronic lung diseases characterized by an imbalance of damaging and protective mechanisms. This review summarizes the recent advances in the development of more efficient gene transfer systems and highlights areas of clinical application of gene therapy.
authors.affiliation: Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St W, Hamilton, ON, Canada L8N 3Z5.
authors.forename: Martin
authors.initials: M
authors.lastname: Kolb
authors.forename: Gail
authors.initials: G
authors.lastname: Martin
authors.forename: Maria
authors.initials: M
authors.lastname: Medina
authors.forename: Kjetil
authors.initials: K
authors.lastname: Ask
authors.forename: Jack
authors.initials: J
authors.lastname: Gauldie
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics / Q000628:therapy; D003550:Cystic Fibrosis / Q000235:genetics / Q000628:therapy; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy; D008171:Lung Diseases / Q000235:genetics* / Q000628:therapy*; D008175:Lung Neoplasms / Q000235:genetics / Q000628:therapy; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics / Q000628:therapy; D000515:alpha 1-Antitrypsin / Q000235:genetics
chemical_list: C505032:CFTR protein, human; D000515:alpha 1-Antitrypsin; D019005:Cystic Fibrosis Transmembrane Conductance Regulator