title: A naturally occurring novel allele of Escherichia coli outer membrane protein A reduces sensitivity to bacteriophage.
abstract: A novel Escherichia coli outer membrane protein A (OmpA) was discovered through a proteomic investigation of cell surface proteins. DNA polymorphisms were localized to regions encoding the protein's surface-exposed loops which are known phage receptor sites. Bacteriophage sensitivity testing indicated an association between bacteriophage resistance and isolates having the novel ompA allele.
authors.affiliation: Department of Biological Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia. mpower@els.mq.edu.au
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Power
authors.forename: Belinda C
authors.initials: BC
authors.lastname: Ferrari
authors.forename: Jane
authors.initials: J
authors.lastname: Littlefield-Wyer
authors.forename: David M
authors.initials: DM
authors.lastname: Gordon
authors.forename: Martin B
authors.initials: MB
authors.lastname: Slade
authors.forename: Duncan A
authors.initials: DA
authors.lastname: Veal
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001315:Australia; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D003090:Coliphages / Q000502:physiology*; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification / Q000821:virology*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D008394:Marsupialia; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; C078167:OMPA outer membrane proteins