title: Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia.
abstract: The aim of this study was to investigate the relationship between the functional C957T single-nucleotide polymorphism of the dopamine D2 receptor (DRD2) gene and the risk for schizophrenia. We therefore conducted a case-control association study of 188 Finnish schizophrenia patients meeting the DSM-IV criteria and 384 healthy controls. The 5' nuclease assay (TaqMan) was used to determine genotypes. A greater proportion of patients with schizophrenia than healthy controls were C-allele carriers (odds ratio 1.5, 95% confidence interval (CI) 1.0-2.3, P=0.05). Our results are in agreement with an earlier association study suggesting that the C957T C-allele plays a role in the genetic vulnerability for schizophrenia and support the involvement of the DRD2 gene in schizophrenia pathogenesis.
authors.affiliation: South Karelia Central Hospital, Department of Psychiatry, Lappeenranta, Finland. kari.hanninen@ekshp.fi
authors.forename: Kari
authors.initials: K
authors.lastname: Hänninen
authors.forename: Heikki
authors.initials: H
authors.lastname: Katila
authors.forename: Olli
authors.initials: O
authors.lastname: Kampman
authors.forename: Sami
authors.initials: S
authors.lastname: Anttila
authors.forename: Ari
authors.initials: A
authors.lastname: Illi
authors.forename: Riikka
authors.initials: R
authors.lastname: Rontu
authors.forename: Kari M
authors.initials: KM
authors.lastname: Mattila
authors.forename: Jarmo
authors.initials: J
authors.lastname: Hietala
authors.forename: Mikko
authors.initials: M
authors.lastname: Hurme
authors.forename: Esa
authors.initials: E
authors.lastname: Leinonen
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D044465:White People
chemical_list: D017448:Receptors, Dopamine D2