title: Serum S100B and antioxidant enzymes in bipolar patients.
abstract: Bipolar disorder (BD) is a chronic, severe, and highly disabling psychiatric disorder; peripheral markers have been used to assess biochemical alterations associated with BD and/or possibly involved in its pathophysiology. Beyond neuronal commitment, many groups have proposed the involvement of glial activity in psychiatric disorders. Other biochemical markers, particularly associated with oxidative stress, have been studied in BD. In the present study, we evaluated glial involvement and oxidative stress in patients with BD. Glial activity was assessed by measuring serum S100B content; oxidative stress was assessed using serum thiobarbituric acid reactive substances (TBARS) and activities of antioxidant enzymes in BD patients during different episodes of disease. We found a significant increment of serum S100B during episodes of mania and depression, but not in euthymic patients. Superoxide dismutase (SOD) activity, as well the SOD/glutathione peroxidase plus catalase ratio, was also increased in manic and depressed patients. On the other hand, TBARS levels were increased in BD patients regardless of the phase of the disorder. These findings suggest a potential oxidative damage in BD patients. This peripheral oxidative imbalance indicates that systemic changes are taking place during the active phases of the illness. Such changes appear to relate to astrocyte function, as indicated by serum S100B elevation.
authors.affiliation: Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600-Anexo, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Andreazza
authors.forename: Carina
authors.initials: C
authors.lastname: Cassini
authors.forename: Adriane Ribeiro
authors.initials: AR
authors.lastname: Rosa
authors.forename: Marina Concli
authors.initials: MC
authors.lastname: Leite
authors.forename: Lucia M V
authors.initials: LM
authors.lastname: de Almeida
authors.forename: Patrícia
authors.initials: P
authors.lastname: Nardin
authors.forename: Angelo B N
authors.initials: AB
authors.lastname: Cunha
authors.forename: Keila Maria
authors.initials: KM
authors.lastname: Ceresér
authors.forename: Aida
authors.initials: A
authors.lastname: Santin
authors.forename: Carmem
authors.initials: C
authors.lastname: Gottfried
authors.forename: Mirian
authors.initials: M
authors.lastname: Salvador
authors.forename: Flavio
authors.initials: F
authors.lastname: Kapczinski
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Gonçalves
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000502:physiology*; D001714:Bipolar Disorder / Q000097:blood* / Q000503:physiopathology*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood*; D003710:Demography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D000975:Antioxidants; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase