title: Treatment of pediatric non-Hodgkin lymphomas in a country with limited resources: results of the first national protocol in Nicaragua.
abstract: We report the results of a protocol for the diagnosis and treatment of pediatric non-Hodgkin lymphomas (NHL) conducted in Nicaragua in the context of an international collaborative program. Fifty-three children with NHL treated between 1996 and 2003 were retrospectively evaluated. Therapy was designed based on local drug availability and affordability with dose and schedule adaptations for Burkitt and lymphoblastic lymphomas. With a median follow-up of 3 years, the projected 9-year overall survival was 63% and event-free survival 53%. The treatment was efficacious, feasible, and well tolerated in spite of the local socio-economical conditions.
authors.affiliation: Pediatric Hemato-Oncology, Department Manuel De Jesus Rivera, La Mascota Hospital, Managua, Nicaragua.
authors.forename: F
authors.initials: F
authors.lastname: Baez
authors.forename: M
authors.initials: M
authors.lastname: Pillon
authors.forename: L
authors.initials: L
authors.lastname: Manfredini
authors.forename: E
authors.initials: E
authors.lastname: Ocampo
authors.forename: G
authors.initials: G
authors.lastname: Mendez
authors.forename: R
authors.initials: R
authors.lastname: Ortiz
authors.forename: R
authors.initials: R
authors.lastname: Palacios
authors.forename: T
authors.initials: T
authors.lastname: Gutierrez
authors.forename: G
authors.initials: G
authors.lastname: Tridello
authors.forename: V
authors.initials: V
authors.lastname: Conter
authors.forename: Mg
authors.initials: M
authors.lastname: Valsecchi
authors.forename: F
authors.initials: F
authors.lastname: Fossati Bellani
authors.forename: F
authors.initials: F
authors.lastname: Cavalli
authors.forename: G
authors.initials: G
authors.lastname: Masera
authors.forename: A
authors.initials: A
authors.lastname: Rosolen
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003906:Developing Countries; D005260:Female; D006801:Humans; D007223:Infant; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D009527:Nicaragua