Efficient Pd(0)-mediated microwave-assisted arylation of 2-substituted imidazo[1,2-a]pyrimidines.
A short and practical synthesis of 2,3-substituted imidazo[1,2-a]pyrimidines, based on microwave-assisted Heck-type arylation of 2-substituted imidazo[1,2-a]pyrimidines, was developed. A 45-membered library of 2,3-substituted imidazo[1,2-a]pyrimidines was obtained with good yields and purities using this optimized protocol.
Ermolat'ev
D S
DS
Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Giménez
V N
VN
Babaev
E V
EV
Van der Eycken
E
E
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008872:Microwaves; D010165:Palladium / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
D052246:Cyclooxygenase 2 Inhibitors; D007093:Imidazoles; D011743:Pyrimidines; D010165:Palladium