title: Novel fibrinogen receptor antagonists--RGDF mimetics, 4-(1,2,3,4-tetrahydro-isoquinoline-7-yl)amino-4-oxo-butyric acid derivatives.
abstract: Two novel RGDF mimetics were synthesized with the use of 4-(1,2,3,4-tetrahydro-isoquinoline-7-yl)amino-4-oxo-butyric acid as a new surrogate of Arg-Gly motif. The synthesized compounds have demonstrated a high potency to inhibit platelet aggregation in vitro and to block FITC-Fg binding to alphaIIbbeta3 on washed human platelets.
authors.affiliation: Department of Medicinal Chemistry, A V Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa. peptides@paco.net
authors.forename: Andrei A
authors.initials: AA
authors.lastname: Krysko
authors.forename: Olga L
authors.initials: OL
authors.lastname: Malovichko
authors.forename: Sergei A
authors.initials: SA
authors.lastname: Andronati
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Kabanova
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Karaseva
authors.forename: Anna S
authors.initials: AS
authors.lastname: Petrus
mesh_terms: D007546:Isoquinolines; D009682:Magnetic Resonance Spectroscopy; D039341:Receptors, Fibrinogen / Q000037:antagonists & inhibitors*; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: C514467:4-(1,2,3,4-tetrahydro-isoquinoline-7-yl)amino-4-oxo-butyric acid; D007546:Isoquinolines; D039341:Receptors, Fibrinogen