Part 3. a novel stereocontrolled, in situ, solution- and solid-phase, Aza Michael approach for high-throughput generation of tetrahydroaminoquinoline-derived natural-product-like architectures.
With the goal of rapidly accessing tetrahydroquinoline-based natural-product-like polycyclic architectures, herein, we report an unprecedented, in situ, stereocontrolled Aza Michael approach in solution and on the solid phase. The mild reaction conditions required to reach the desired target are highly attractive for the use of this method in library generation. To our knowledge, this approach has not been used before, and it opens a novel route leading to a wide variety of tetrahydroquinoline-derived bridged tricyclic derivatives.
Prakesch
Michael
M
Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6.
Srivastava
Stuti
S
Leek
Donald M
DM
Arya
Prabhat
P
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D000634:Aminoquinolines / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D000634:Aminoquinolines; D015335:Molecular Probes; D011083:Polycyclic Compounds; D012996:Solutions