Lack of neutralizing antibody response to HIV-1 predisposes to superinfection.
Occurrences of HIV-1 superinfection offer a unique opportunity to investigate the correlates of immune protection. Here we describe the neutralizing antibody responses of a cohort of recently infected individuals who were screened for HIV superinfection. Three individuals identified with HIV superinfection had less cross-protective and autologous neutralizing antibody response than their non-superinfected case-controls. Neutralizing antibody may be crucial in the protection against superinfection and may explain why superinfection has only been documented following recent infection or treatment interruption. These data have considerable implications for vaccine development.
Smith
Davey M
DM
University of California San Diego, La Jolla, CA 92093-0679, USA. davey@ucsd.edu
Strain
Matthew C
MC
Frost
Simon D W
SD
Pillai
Satish K
SK
Wong
Joseph K
JK
Wrin
Terri
T
Liu
Yang
Y
Petropolous
Christos J
CJ
Daar
Eric S
ES
Little
Susan J
SJ
Richman
Douglas D
DD
D000328:Adult; D016022:Case-Control Studies; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009500:Neutralization Tests; D015163:Superinfection / Q000276:immunology* / Q000821:virology
D015483:HIV Antibodies