title: Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination.
abstract: A 3-year retrospective study evaluated the effectiveness and safety of cefepime plus a fluoroquinolone for treating bone and joint infections caused by Gram-negative bacilli (GNB) in 28 patients. Intra-operative cultures yielded primarily Pseudomonas spp. and Enterobacter cloacae. Full recovery (cure) was observed in 79% of patients. There were no serious adverse effects and no resistant organisms were isolated. The results of the study confirmed the safety and effectiveness of cefepime combined with a fluoroquinolone for the treatment of bone and joint infections caused by Gram-negative bacilli.
authors.affiliation: Division of Infectious Diseases, University of Lille, Dron Hospital, Tourcoing, France. laurence.legout@hcuge.ch
authors.forename: L
authors.initials: L
authors.lastname: Legout
authors.forename: E
authors.initials: E
authors.lastname: Senneville
authors.forename: R
authors.initials: R
authors.lastname: Stern
authors.forename: Y
authors.initials: Y
authors.lastname: Yazdanpanah
authors.forename: C
authors.initials: C
authors.lastname: Savage
authors.forename: M
authors.initials: M
authors.lastname: Roussel-Delvalez
authors.forename: B
authors.initials: B
authors.lastname: Rosele
authors.forename: H
authors.initials: H
authors.lastname: Migaud
authors.forename: Y
authors.initials: Y
authors.lastname: Mouton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001850:Bone Diseases, Infectious / Q000188:drug therapy*; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002939:Ciprofloxacin; D000077723:Cefepime; D015242:Ofloxacin