title: Detailed analysis of myocardial motion in volunteers and patients using high-temporal-resolution MR tissue phase mapping.
abstract: OBJECTIVE
  To detect and investigate details in left ventricular (LV) motion patterns with a temporal resolution comparable to that of echocardiography.
  
  
  METHODS
  To assess global and regional myocardial motion in high temporal detail, respiratory-gated MR phase-contrast measurements with three-directional velocity encoding (venc) were performed in 12 healthy volunteers and two patients with LV hypertrophy in basal, midventricular, and apical locations of the LV with a temporal resolution of 13.8 msec.
  
  
  RESULTS
  The volunteer data revealed details in LV motion patterns that were known only from echocardiography. For all volunteers, characteristic myocardial motion patterns, such as triphasic global diastolic expansion, could be detected with high accuracy. One volunteer underwent an additional echocardiographic measurement in order to corroborate the complex motion features as measured by MRI. Patient examinations revealed substantial changes in diastolic function compared to motion patterns in healthy volunteers.
  
  
  CONCLUSIONS
  The proposed high-temporal-resolution velocity-mapping technique provides previously undetectable information on LV performance, and is highly promising for the detection of local and global motion abnormalities in patients with disturbed LV performance, such as diastolic dysfunction.
authors.affiliation: Department of Diagnostic Radiology, Medical Physics, University Hospital, Freiburg, Germany. bernd.jung@uniklinik-freiburg.de
authors.forename: Bernd
authors.initials: B
authors.lastname: Jung
authors.forename: Daniela
authors.initials: D
authors.lastname: Föll
authors.forename: Petra
authors.initials: P
authors.lastname: Böttler
authors.forename: Steffen
authors.initials: S
authors.lastname: Petersen
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hennig
authors.forename: Michael
authors.initials: M
authors.lastname: Markl
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000175:diagnosis*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009200:Myocardial Contraction; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000175:diagnosis*