title: Decrements in the thrombin activatable fibrinolysis inhibitor (TAFI) levels in association with orlistat treatment in obesity.
abstract: Obesity and its associated metabolic complications can impair the physiologic regulation of fibrinolysis, leading to a hyper coagulable state. We aimed to assess circulating thrombin activatable fibrinolysis inhibitor (TAFI) levels in obese female patients and to test the effects of orlistat-induced weight loss on basal TAFI concentrations. Obese female outpatients age 18 and older, with a body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) of at least 30, were included into the study. Thirteen nonobese (median BMI, 22.60 kg/m(2)) age-matched females were taken as controls. Plasma TAFI levels were measured before orlistat administration and after 6 months of orlistat treatment in the obese group and only one measurement was done in the control group. Twenty-seven obese patients were recruited into the study. The median TAFI level of the control group was 124.00; this value was significantly lower than the basal TAFI level of the obese group (p < 0.001). TAFI levels after orlistat therapy were statistically significantly lower than basal TAFI levels (p < 0.001) in the obese group. Hemostatic abnormalities including TAFI alterations represent a link between obesity and vascular thrombosis. Effective interventions should be considered in improving the obesity-associated prothrombotic risk profile.
authors.affiliation: Department of Internal Medicine, Section of General Internal Medicine, Hacettepe University Medical School, Ankara, Turkey. gsain@tr.net
authors.forename: Gulay Sain
authors.initials: GS
authors.lastname: Guven
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Kiliçaslan
authors.forename: S Gul
authors.initials: SG
authors.lastname: Oz
authors.forename: Ibrahim C
authors.initials: IC
authors.lastname: Haznedaroglu
authors.forename: Serafettin
authors.initials: S
authors.lastname: Kirazli
authors.forename: Dilek
authors.initials: D
authors.lastname: Aslan
authors.forename: Tümay
authors.initials: T
authors.lastname: Sözen
mesh_terms: D000328:Adult; D001837:Body Weights and Measures; D025901:Carboxypeptidase B2 / Q000097:blood / Q000187:drug effects*; D016022:Case-Control Studies; D005260:Female; D006487:Hemostasis; D006801:Humans; D007783:Lactones / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D000077403:Orlistat; D013927:Thrombosis
chemical_list: D007783:Lactones; D000077403:Orlistat; D025901:Carboxypeptidase B2