title: Further investigation of the tolerance and mechanical adjustability of the *Acri.Tec AR-1 PC/IOL in rabbit eyes: an intraocular lens with reversibly adjustable optical power.
abstract: OBJECTIVE
  To examine the tolerance and mechanical function of an adjustable intraocular lens (IOL) in rabbit eyes.
  
  
  METHODS
  Implantation of the *Acri.Tec AR-1 PC/IOL into 14 rabbit eyes. Manipulation of the lens 8 weeks after implantation in order to change the refractive power. Follow-up for up to 5 months. Histopathologic examination of the eyes.
  
  
  RESULTS
  Implantation and mechanical adjustment of the PC/IOL were possible. Eyes healed normally. No difference between eyes containing the *Acri.Tec AR-1 PC/IOL and eyes containing the control PC/IOL could be detected with respect to signs of inflammatory reaction, corneal transparency, intraocular pressure and histopathologic appearance. Histopathologic examination of the eyes showed that the *Acri.Tec AR-1 PC/IOL did not cause any damage in rabbit eyes.
  
  
  CONCLUSIONS
  The *Acri.Tec AR-1 PC/IOL is well tolerated in rabbit eyes for extended periods of time, suggesting that this PC/IOL should be well tolerated in the long run. Surgical adjustment of the adjusting element can be performed with little effort several weeks after implantation.
authors.affiliation: Augenpraxisklinik Dr. Jahn, Kempten, Germany.
authors.forename: Claus E
authors.initials: CE
authors.lastname: Jahn
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Fromberg
authors.forename: Nicole
authors.initials: N
authors.lastname: Fesser
authors.forename: Ingrid
authors.initials: I
authors.lastname: Allgoewer
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Jahn
authors.forename: Nina S
authors.initials: NS
authors.lastname: Wakili
authors.forename: Carmen R
authors.initials: CR
authors.lastname: Hofmann-Rummelt
authors.forename: Leonard M
authors.initials: LM
authors.lastname: Holbach
authors.forename: Bernd A
authors.initials: BA
authors.lastname: Kamppeter
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D007108:Immune Tolerance; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000601:surgery; D007910:Lenses, Intraocular; D055095:Optics and Photonics; D019904:Polymethyl Methacrylate; D011474:Prosthesis Design; D017755:Prosthesis Fitting; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D019904:Polymethyl Methacrylate