Preservation of renal function and cardiovascular risk factors.
An update is given about some factors leading to loss of renal allograft, especially in relation to the use of tacrolimus and cyclosporine. We discuss both immunological, such as suboptimal immunosuppression, acute rejection, and noncompliance, as well as nonimmunological factor's such as hypertension, hyperlipidemia, chronic toxic effects of immunosuppressants, older donors, and delayed graft function.
van Hooff
J P
JP
University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands. jho@sint.azm.nl
Gelens
M
M
Boots
J M
JM
van Duijnhoven
E M
EM
Dackus
J
J
Christiaans
M H
MH
D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000453:epidemiology; D016572:Cyclosporine / Q000009:adverse effects; D006085:Graft Survival / Q000276:immunology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000276:immunology*; D012307:Risk Factors; D016559:Tacrolimus / Q000009:adverse effects; D017211:Treatment Failure
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus