title: Lithiation directed by amino alkoxides. Application to the synthesis of new disubstituted dihydrodipyridopyrazines.
abstract: The synthesis of new 4,6-disubstituted dihydrodipyridopyrazines starting from corresponding carboxaldehydes via lithiation directed by alpha-amino alkoxides is described. The N,N,N'-trimethylethylenediamine was used as amine component for in situ formation of the alpha-amino alkoxides. After optimization, this reaction allowed easy access to new interesting starting materials for further applications by palladium-catalyzed reactions.
authors.affiliation: Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France.
authors.forename: Irina-Claudia
authors.initials: IC
authors.lastname: Grig-Alexa
authors.forename: Adriana-Luminita
authors.initials: AL
authors.lastname: Fînaru
authors.forename: Paul
authors.initials: P
authors.lastname: Caubère
authors.forename: Gérald
authors.initials: G
authors.lastname: Guillaumet