Cytochalasin D as the depressant of contraction for the optical monitoring of action potentials in isolated rat atrium.
We used cytochalasin D to reduce contraction-related optical signals by inhibiting muscle contraction for the optical monitoring of action potentials, using a voltage-sensitive dye in isolated rat atrium preparations. The suppression of contraction-related signals was so strong that we concluded that this chemical is suitable for this purpose.
Sakai
Tetsuro
T
Department of Physiology, University of the Ryukyus School of Medicine, Nishihara, Okinawa, 903-0215, Japan. tsakai@med.u-ryukyu.ac.jp
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D015638:Cytochalasin D / Q000378:metabolism*; D004594:Electrophysiology; D005260:Female; D006325:Heart Atria / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology*; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D019384:Nucleic Acid Synthesis Inhibitors; D015638:Cytochalasin D