title: Characterization of a phenotypically unique population of CD13+ dendritic cells resident in the spleen.
abstract: Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a(+) CD11c(+) CD13(+) CD172(+) CD205(+) population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, 99164-7040, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Waithaka
authors.initials: W
authors.lastname: Mwangi
authors.forename: Wendy C
authors.initials: WC
authors.lastname: Brown
authors.forename: William C
authors.initials: WC
authors.lastname: Davis
authors.forename: Jayne C
authors.initials: JC
authors.lastname: Hope
authors.forename: Guy H
authors.initials: GH
authors.lastname: Palmer
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism; D000938:Antigen-Presenting Cells / Q000276:immunology; D018826:CD13 Antigens / Q000378:metabolism*; D002417:Cattle; D018929:Cell Culture Techniques; D002469:Cell Separation; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000032:analysis / Q000276:immunology; D008297:Male; D010641:Phenotype; D013154:Spleen / Q000166:cytology* / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D007132:Immunoglobulin Isotypes; D018826:CD13 Antigens