Definition and current evaluation of subfertile men.
Male infertility affects 10% of reproductive aged couples worldwide and is treatable in many cases. In addition to other well-described etiologies, genetic causes of male infertility are now more commonly diagnosed. Using principles of evidence-based medicine, this review outlines diagnostic and treatments options to inform clinical management. In order of importance, randomized controlled clinical trials, basic scientific studies, meta-analyses, case-controlled cohort studies, best-practice policy recommendations and reviews from peer-reviewed literature were incorporated that provide organized and timely guidelines to the current management of male infertility. The strength of evidence for treatment recommendations is also classified when appropriate.
Shefi
Shai
S
Department of Urology, University of California San Francisco, San Francisco, California 94143-1695, USA.
Turek
Paul J
PJ
D019317:Evidence-Based Medicine; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008297:Male