[Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice].
OBJECTIVE
To observe the effects of ethanol extracts of Panax notoginseng on the tumor and the liver metastasis in experimental mice grafted with B16 melanoma.


METHODS
B16 melanoma was transplanted in the spleen of C57BL/6 mice. The effects of different doses of ethanol extracts of Panax notoginseng on the inhibition rate of spleen tumors and the liver metastasis were observed respectively.


RESULTS
The high-, medium-, and low-doses of the extracts and the interferon-alpha (IFN-alpha) can improve the quality of life of the experimental mice. The weights of spleen tumor were lower in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the normal saline (NS)-treated group (P<0.05 or P<0.01). The liver metastasis was less in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the NS-treated group (P<0.01).


CONCLUSIONS
The ethanol extracts of Panax notoginseng can improve the quality of life of the experimental mice and inhibit the growth of tumor and the liver metastasis.
Chen
Pei-Feng
PF
Department of Oncology, First Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang Province 310006, China. cpf12345@163.com
Liu
Lu-Ming
LM
Chen
Zhen
Z
Lin
Sheng-You
SY
Song
Wei-Xiang
WX
Xu
Ying-Fei
YF
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D000431:Ethanol / Q000737:chemistry; D005260:Female; D016898:Interferon-alpha / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D053723:Panax notoginseng / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D011897:Random Allocation; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D016898:Interferon-alpha; D010936:Plant Extracts; D000431:Ethanol