[Effects of xipayi mouth rinse on the DNA synthesis and change of cell cycles of human gingival fibroblast induced by lipopolysaccharide].
OBJECTIVE
To observe the effects of xipayi mouth rinse on the DNA synthesis and change of cell cycles of human gingival fibroblast (HGF) induced by lipopolysaccharide(LPS).


METHODS
HGF was stimulated with LPS at 25 mg/L. Flow cytometry was used to examine the effect of xipayi mouth rinse at 25 mg/L on the DNA synthesis and change of HGF cell cycles.


RESULTS
The percentage of HGF in G( 1) phase increased after the cells were induced by LPS, while the percentage of HGF in S phase decreased. Xipayi mouth rinse could ameliorate this phenomenon.


CONCLUSIONS
Xipayi mouth rinse can significantly ameliorate the inhibitory effect of LPS on the proliferation of HGF, suggesting the anti-inflammatory effect of xipayi mouth rinse in the treatment and prevention of periodontal diseases.
Aibibai
Yusufu
Y
Department of Endocrinology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
Hamulati
Wufuer
W
Zhong
Liang-jun
LJ
D002453:Cell Cycle / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D005881:Gingiva / Q000166:cytology*; D006801:Humans; D008070:Lipopolysaccharides; D009067:Mouthwashes / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D009067:Mouthwashes; D004247:DNA