[Th1 and Th2 lymphocytes in perennial allergic rhinitis].
BACKGROUND
The study of perennial allergic rhinitis is a good model to evidence the unbalance between Th1 and Th2 lymphocytes. This functional unbalance is manifested by the exaggerated production of pro-inflammatory cytokines and a reduction of the antiinflammatory ones.


OBJECTIVE
To corroborate these alterations in patients with perennial allergic rhinitis. PATIENTS AMD METHOD: In nine patients with perennial allergic rhinitis who had no immunotherapy treatment we measured the IFNgamma, IL-4, IL-10 and IL-13 levels through a flow citometry.


RESULTS
We found high levels of IL-10 (42%) and reduced IFNgamma values. We did not find IL-4 or IL-13 expressions in the studied patients.


CONCLUSIONS
These results make us to consider a Th1/Th2 unbalance towards a Th2 hyperfunction.
Aguilar Angeles
Daniel
D
Servicio de alergia e inmunologia clinica, Hospital Juárez de México.
Serrano Miranda
Ernestina
E
Rojo Gutiérrez
María Isabel
MI
Bermejo Guevara
Mario A
MA
Estrada Parra
Sergio
S
D000328:Adult; D006801:Humans; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*