No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia.
Mutations of the chromatin modifying protein 2B gene (CHMP2B) were identified, in a Danish pedigree, to cause familial frontotemporal dementia (FTD). To explore the possible genetic contribution of common CHMP2B variants in sporadic FTD, we analyzed 14 single nucleotide polymorphisms covering the entire genomic region of CHMP2B. After adjustment for multiple testing single marker and haplotype analysis revealed no significant association with sporadic FTD. Thus, we conclude that CHMP2B can be excluded as a susceptibility gene conferring risk to sporadic forms of FTD.
Schumacher
Axel
A
Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, Munich, Germany.
Friedrich
Patricia
P
Diehl-Schmid
Janine
J
Ibach
Bernd
B
Eisele
Tamara
T
Laws
Simon M
SM
Förstl
Hans
H
Kurz
Alexander
A
Riemenschneider
Matthias
M
D000368:Aged; D003704:Dementia / Q000235:genetics* / Q000378:metabolism*; D056827:Endosomal Sorting Complexes Required for Transport; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
C503812:CHMP2B protein, human; D056827:Endosomal Sorting Complexes Required for Transport; D009419:Nerve Tissue Proteins