Successful treatment of disseminated mucormycosis with a combination of liposomal amphotericin B and posaconazole in a patient with acute myeloid leukaemia.
The combination of resection of infected tissue and antifungal therapy is the treatment of choice in mucormycosis. In disseminated mucormycosis, where surgery is impossible, the mortality is almost 90%. We report the first case of disseminated mucormycosis that was cured with a combination therapy of liposomal amphotericin B and posaconazole without surgical intervention.
Rickerts
V
V
Medizinische Klinik II, Klinikum der J.W. Goethe Universitaet, Frankfurt, Germany. rickerts@em.uni-frankfurt.de
Atta
J
J
Herrmann
S
S
Jacobi
V
V
Lambrecht
E
E
Bialek
R
R
Just-Nübling
G
G
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008081:Liposomes / Q000627:therapeutic use*; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy*; D020103:Rhizomucor / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D008081:Liposomes; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B