Impact of sample size on the performance of multiple-model pharmacokinetic simulations.
Monte Carlo simulations are increasingly used to predict pharmacokinetic variability of antimicrobials in a population. We investigated the sample size necessary to provide robust pharmacokinetic predictions. To obtain reasonably robust predictions, a nonparametric model derived from a sample population size of >/=50 appears to be necessary as the input information.
Tam
Vincent H
VH
University of Houston College of Pharmacy, 1441 Moursund Street, Houston, TX 77030, USA. vtam@uh.edu
Kabbara
Samer
S
Yeh
Rosa F
RF
Leary
Robert H
RH
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D006801:Humans; D009010:Monte Carlo Method; D010599:Pharmacokinetics; D011153:Population; D018401:Sample Size
D000900:Anti-Bacterial Agents