Endoscopic, rapid near-infrared optical tomography.
This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source-detector fibers for tomography as well as parallel sampling of all source-detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.
Piao
Daqing
D
School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, Oklahoma, USA. daqing.piao@okstate.edu
Xie
Hao
H
Zhang
Weili
W
Krasinski
Jerzy S
JS
Zhang
Guolong
G
Dehghani
Hamid
H
Pogue
Brian W
BW
D003199:Computer Systems; D019723:Endoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*