title: Application of the EMIT 2000 Tacrolimus assay on the Abbott Architect c8000 high volume clinical chemistry analyzer.
abstract: OBJECTIVE
  Evaluation of the performance of the EMIT 2000 Tacrolimus assay on the Abbott Architect c8000 analyzer.
  
  
  METHODS
  Imprecision studies were performed and patient samples were assayed by EMIT assay and by LC-MS/MS.
  
  
  RESULTS
  Limit of quantification was established at 2.8 microg/L. A positive bias of 17.5% between results measured on EMIT and on LC-MS/MS was detected.
  
  
  CONCLUSIONS
  EMIT 2000 Tacrolimus assay is suitable for automated analyses of Tacrolimus on the Architect c8000.
authors.affiliation: Institut fur Klinische Chemie und Labordiagnostik FSU Jena, Germany. kboeer@med.uni-jena.de
authors.forename: Klas
authors.initials: K
authors.lastname: Boer
authors.forename: Thomas
authors.initials: T
authors.lastname: Deufel
authors.forename: Dirk
authors.initials: D
authors.lastname: Schmidt
authors.forename: Sibylle
authors.initials: S
authors.lastname: Streck
authors.forename: Michael
authors.initials: M
authors.lastname: Kiehntopf
mesh_terms: D002853:Chromatography, Liquid; D019963:Clinical Chemistry Tests / Q000295:instrumentation*; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood*; D013058:Mass Spectrometry; D012015:Reference Standards; D015203:Reproducibility of Results; D016559:Tacrolimus / Q000097:blood*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus