title: Molecular differentiation of Treponema pallidum subspecies.
abstract: Treponema pallidum includes three subspecies of antigenically highly related treponemes. These organisms cause clinically distinct diseases and cannot be distinguished by any existing test. In this report, genetic signatures are identified in two tpr genes which, in combination with the previously published signature in the 5' flanking region of the tpp15 gene, can differentiate the T. pallidum subspecies, as well as a simian treponeme.
authors.affiliation: Department of Medicine, University of Washington, Seattle, 98195, USA. acentur@u.washington.edu
authors.forename: Arturo
authors.initials: A
authors.lastname: Centurion-Lara
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Molini
authors.forename: Charmie
authors.initials: C
authors.lastname: Godornes
authors.forename: Eileen
authors.initials: E
authors.lastname: Sun
authors.forename: Karin
authors.initials: K
authors.lastname: Hevner
authors.forename: Wesley C
authors.initials: WC
authors.lastname: Van Voorhis
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Lukehart
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D001483:Base Sequence; D004269:DNA, Bacterial / Q000032:analysis; D006801:Humans; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D011817:Rabbits; D013045:Species Specificity; D013587:Syphilis / Q000382:microbiology; D014210:Treponema pallidum / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D014211:Treponemal Infections / Q000382:microbiology
chemical_list: D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; C406409:Tpr protein, Treponema