title: Electroencephalographic responses to intraoperative subthalamic stimulation.
abstract: This study reports the effects of intraoperative stimulation of the subthalamic nucleus on brain electrical activity in advanced Parkinson's patients. To our knowledge, this is the first study about electroencephalographic responses in the very early phase of deep brain stimulation, during the implantation of the electrodes. We found an increase of gamma band bilaterally over the sensorimotor cortex in the range 45-55 Hz, which was associated with clinical improvement as assessed by means of muscle rigidity decrease. These results indicate that the electroencephalographic gamma responses to deep brain stimulation are present at the very beginning of the treatment process, and may help better understand the short and long-tem effects of deep brain stimulation.
authors.affiliation: Department of Neuroscience, University of Turin Medical School, Turin bS. Maugeri Foundation, Pavia, Italy. luana.colloca@unito.it
authors.forename: Luana
authors.initials: L
authors.lastname: Colloca
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Benedetti
authors.forename: Bruno
authors.initials: B
authors.lastname: Bergamasco
authors.forename: Sergio
authors.initials: S
authors.lastname: Vighetti
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zibetti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ducati
authors.forename: Michele
authors.initials: M
authors.lastname: Lanotte
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lopiano
mesh_terms: D000368:Aged; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation / Q000379:methods*; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery; D013057:Spectrum Analysis; D020531:Subthalamic Nucleus / Q000528:radiation effects* / Q000601:surgery