Percutaneous absorption of crotamiton in man following single and multiple dosing.
OBJECTIVE
Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin.


METHODS
We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose regimen by measuring urinary excretion and liquid scintillation counting in three groups of four healthy volunteers. The Feldmann urinary excretion method was utilized to ascertain percutaneous absorption. Our results showed that tape stripping does not increase percutaneous absorption of crotamiton; upon repeated application.
Dika
E
E
Università degli Studi di Bologna, Dipartimento di Medicina Clinica Specialistica e Sperimentale Sezione di Clinica Dermatologica, Italy. emi.dika@tin.it
Tosti
A
A
Goldovsky
M
M
Wester
R
R
Maibach
H I
HI
D000279:Administration, Cutaneous; D000982:Antipruritics / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D002250:Carbon Radioisotopes; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D012869:Skin Absorption; D014052:Toluidines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
D000982:Antipruritics; D002250:Carbon Radioisotopes; D014052:Toluidines; C005553:crotamiton