title: Cardiovascular effects of continuous propofol infusion in horses.
abstract: We examined the influence of propofol infusion on cardiovascular system at the rate of 0.14, 0.20 and 0.30 mg/kg/min in six adult Thoroughbred horses. The cardiovascular parameters were heart rate (HR), mean arterial pressure (MAP), mean right atrial pressure (MRAP), stroke volume (SV), cardiac output (CO), systemic vascular resistance (SVR), pre-ejection period (PEP) and ejection time (ET). In order to keep the ventilation conditions constantly, intermittent positive pressure ventilation was performed, and the partial arterial CO(2) pressure was maintained at 45 to 55 mmHg during maintenance anesthesia. SV showed a significant dose-dependent decrease however, CO did not show significant change. SVR decreased significantly at higher dose. PEP was prolonged and PEP/ET increased significantly at the highest dose. From these results, it became clear that SV decreases dose-dependently due to decrease of cardiac contractility during anesthesia with continuous propofol infusion in horses. On the other hand, since MAP and CO did not show significant changes, total intravenous anesthesia with propofol was suggested to be suitable for long-term anesthesia in horses.
authors.affiliation: Racehorse Clinic, Miho Training Center, Japan Racing Association, Shiga, Japan.
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Oku
authors.forename: Minoru
authors.initials: M
authors.lastname: Ohta
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Katoh
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Moriyama
authors.forename: Kanichi
authors.initials: K
authors.lastname: Kusano
authors.forename: Toru
authors.initials: T
authors.lastname: Fujinaga
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006736:Horses; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol