Genetics of SLE in mice.
Genetic studies in spontaneous, induced, and gene-manipulated mouse models of SLE have provided significant insights into the potential number and diversity of genes that can promote, resist, and modify lupus susceptibility. Novel genes and mechanisms of disease pathogenesis have also been identified. Importantly, mouse models have provided an initial view of the genomic landscape of lupus-affecting genes, and have documented the complexities of verifying and determining the role of specific candidate loci and genes. Mouse models of lupus should continue to serve as a vital approach to defining the genetics of SLE.
Kono
Dwight H
DH
Department of Immunology/IMM3, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. dkono@scripps.edu
Theofilopoulos
Argyrios N
AN
D000818:Animals; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000473:pathology; D051379:Mice; D040641:Quantitative Trait Loci