An ARC light on lipid metabolism.
The SREBP pathway plays a central role in the regulation of lipid metabolism. In a recent letter, Yang et al. present a comprehensive series of experiments, spanning a wide range of disciplines, that identify ARC105 as a component of the ARC complex that interacts directly with SREBP and is necessary for SREBP function (Yang et al., 2006).
Rawson
Robert B
RB
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
D000818:Animals; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008055:Lipids / Q000096:biosynthesis; D046911:Macromolecular Substances / Q000378:metabolism; D056892:Mediator Complex; D011485:Protein Binding / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D050436:Regulatory Elements, Transcriptional / Q000502:physiology; D051779:Sterol Regulatory Element Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology
D008055:Lipids; C416944:MED15 protein, human; D046911:Macromolecular Substances; D056892:Mediator Complex; D051779:Sterol Regulatory Element Binding Proteins; D014157:Transcription Factors