title: Accelerated acquisition of permeability barrier function in the skin of presenilin-1-deficient embryos.
abstract: Presenilin-1 (PS1) is a transmembrane protein and is responsible for the development of early-onset familial Alzheimer's disease. PS1 is essential for neurogenesis, somitogenesis, angiogenesis and cardiac morphogenesis. We report here that PS1 is involved in the development of skin barrier function. PS1-deficient embryos showed an accelerated acquisition of permeability barrier function at embryonic day 17.5 as manifested by the exclusion of a dye solution. While the expression of beta-catenin and epidermal differentiation markers such as keratin 1 and loricrin was not substantially altered, an increased accumulation of E-cadherin was observed immunohistochemically in the mutant skin. These results suggest that PS1 regulates the acquisition of permeability barrier function in the skin.
authors.affiliation: Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan.
authors.forename: Mitsunari
authors.initials: M
authors.lastname: Nakajima
authors.forename: Minetaro
authors.initials: M
authors.lastname: Ogawa
authors.forename: Yuri
authors.initials: Y
authors.lastname: Shimoda
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Koseki
authors.forename: Takuji
authors.initials: T
authors.lastname: Shirasawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Furukawa
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D007365:Intercellular Junctions / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010539:Permeability; D053764:Presenilin-1 / Q000235:genetics / Q000502:physiology*; D012867:Skin / Q000166:cytology / Q000196:embryology*; D012879:Skin Physiological Phenomena / Q000235:genetics*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D015820:Cadherins; D053764:Presenilin-1; D051176:beta Catenin