[Autoantigen and molecular chaperone in rheumatoid arthritis--their roles in metabolism of chondrocytes].
The endoplasmic reticulum chaperone; heat shock protein/rheumatoid arthritis-related antigen (HSP47/RA-A47), in addition to its important intercellular functions for collagen maturation and secretion, has chondrocytes-destructive roles such as induction of endoplasmic reticulum (ER)-stress and metabolic gene expressions result in apoptosis when HSP47/RA-A47 is downregulated. Extracellular HSP47/RA-A47 may act as an autoantigen, but also regulate autoimmune inflammation. It is, therefore, a potential new biologic therapy for rheumatoid arthritis.
Hattori
Takako
T
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Biochemistry & Molecular Dentistry.
Takigawa
Masaharu
M
D017209:Apoptosis / Q000235:genetics; D001172:Arthritis, Rheumatoid / Q000209:etiology* / Q000628:therapy; D001324:Autoantigens / Q000502:physiology*; D015551:Autoimmunity; D003094:Collagen / Q000378:metabolism; D015536:Down-Regulation; D004721:Endoplasmic Reticulum / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D050958:HSP47 Heat-Shock Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D018832:Molecular Chaperones / Q000502:physiology*
D001324:Autoantigens; D050958:HSP47 Heat-Shock Proteins; D018832:Molecular Chaperones; D003094:Collagen