[Genetic variations of the tumor suppressor TP53: outstanding and strategies of analysis].
In the modern society, cancer remains an important cause of death. Cancer development is a very complex process that involves alterations in genes regulating cellular growth. Among these alterations or variations, are included point mutations, genetic susceptibility by single nucleotide polymorphisms or "SNP" and alteration or loss in tumor suppressor genes functions. The tumor suppressor TP53 is one of the most important and studied genes on cancer genetics. Therefore, it has been demonstrated that TP53 present mutations in more than 50% of all types of human cancer and encodes a multifunctional protein whose absence contributes to genomic instability, the accumulation of mutations and increased tumor development. The identification of such alterations in cancerous cells at level of single nucleotide is very important, because its implication in the loss or alteration in the function of this gene, its clinical relevance and finally, its association with response to therapy and prognosis. Due to the large interesting issue, in this work we are focused only in two of the most common genetic variations present in this gene: the point mutations and SNP remarking some outstanding molecular characteristics needed for design its analysis.
Rangel-López
Angélica
A
Laboratorio de Oncología Genómica, Unidad de Investigación Médica en Enfermedades Oncológicas, Hospital de Oncología, Centro Médico Nacional Siglo XXI-IMSS, México, DF. ragn62@prodigy.net.mx
Piña-Sánchez
Patricia
P
Salcedo
Mauricio
M
D003043:Cocarcinogenesis; D004252:DNA Mutational Analysis; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D042822:Genomic Instability; D006801:Humans; D019656:Loss of Heterozygosity; D020125:Mutation, Missense; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000172:deficiency / Q000502:physiology
D016159:Tumor Suppressor Protein p53