Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata.
Two new rocaglamide derivatives, 1-O-formylrocagloic acid (1) and 3'-hydroxy rocagloic acid (2), together with five known compounds, rocaglaol (3), rocagloic acid (4), 3'-hydroxymethylrocaglate (5), 1-O-formylmethyl rocaglate (6), and methylrocaglate (7), were isolated from the fruits of Amoora cucullata. Their structures were elucidated by spectroscopic methods. Compounds 1-3, 6, and 7 exhibited potent cytotoxicity against KB, BC, and NCI-H187 cell lines, whereas 4 and 5 showed selective cytotoxicity against NCI-H187 cell line.
Chumkaew
Parinuch
P
School of Science and Research Unit of Natural Products Utilization, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand.
Kato
Shigeru
S
Chantrapromma
Kan
K
D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D012015:Reference Standards; D012639:Seeds / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C514038:1-O-formylrocagloic acid; C514039:3'-hydroxymethylrocaglate; D001572:Benzofurans; C510144:rocaglaol; C428175:rocagloic acid; C107772:rocaglamide