title: General and rhinosinusitis-related quality of life in patients with Wegener's granulomatosis.
abstract: OBJECTIVE
  The objectives of this cross-sectional study were to outline the pattern of sinonasal morbidity and determine its effects on the quality of life (QOL) of patients with Wegener's granulomatosis (WG).
  
  
  METHODS
  The authors conducted a survey of 199 patients with WG, including two validated (QOL) instruments to assess general (SF-36) and rhinosinusitis-specific quality of life (Sinonasal Outcome Test [SNOT-22]).
  
  
  RESULTS
  Patients with WG who have sinonasal involvement reported significantly lower general QOL scores than their unaffected counterparts (P = .000006-0.04) for all SF-36 subsets except for emotional role. WG-related sinonasal morbidity was comparable to the high levels previously demonstrated in the general rhinosinusitis population. A total of 38.2% of all patients with WG reported a nasal symptom as their most troublesome from a list of nasal and constitutional symptoms. Twenty-three percent of all patients with WG rated nasal crusting and 17% rated epistaxis as one of their top three most troublesome symptoms even in the setting of multisystem disease. The inclusion of crusting, bleeding, and nasal deformity in the SNOT scoring significantly increased average scores of patients with WG (P = .024, paired t test).
  
  
  CONCLUSIONS
  Sinonasal involvement impacts significantly on the general QOL of patients with WG and is at least as significant as that of the general rhinosinusitis population. Nasal symptoms that are of particular relevance to this patient group include nasal crusting and epistaxis.
authors.affiliation: ENT Department, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: I A
authors.initials: IA
authors.lastname: Srouji
authors.forename: P
authors.initials: P
authors.lastname: Andrews
authors.forename: C
authors.initials: C
authors.lastname: Edwards
authors.forename: V J
authors.initials: VJ
authors.lastname: Lund
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000523:psychology*; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012220:Rhinitis / Q000523:psychology*; D012852:Sinusitis / Q000523:psychology*; D011795:Surveys and Questionnaires