title: Stable helical beta 3-peptides in water via covalent bridging of side chains.
abstract: An on-bead cyclization protocol of beta 3-peptides was developed, providing easy access to cyclic beta 3-peptides. With this methodology, a small library of helical cyclic beta 3-peptides was synthesized and investigated with CD spectroscopy. Covalent bridging of two side chains in beta 3-peptides significantly stabilized their helical conformation in aqueous solutions and turned out to be superior to the previously described electrostatic interactions.
authors.affiliation: Max Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, D-44227, Dortmund, Germany.
authors.forename: Esther
authors.initials: E
authors.lastname: Vaz
authors.forename: Luc
authors.initials: L
authors.lastname: Brunsveld
mesh_terms: D002942:Circular Dichroism; D010455:Peptides / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D010455:Peptides; D014867:Water