title: Exploiting the properties of adult stem cells for the treatment of disease.
abstract: Much of the current hope in regenerative medicine is intimately entwined with promises that stern cells will provide the backbone for cell-replacement therapies to treat various degenerative, genetic and malignant conditions. The realization that a wide range of adult tissues contain stem cells has heightened this optimism, and ultimately the expectation that these somatic cells can be harnessed to provide cell-based therapies that will soon be realized in the clinic. This review discusses the recent advances in adult stem-cell technology that have captured significant attention and discusses progress in the development of two distinct methodologies currently being exploited in regenerative medicine strategies.
authors.affiliation: Karolinska Institute, Department of Clinical Neuroscience, Center for Hearing and Communication Research, Building M1, Stockholm, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Erlandsson
authors.forename: Cindi M
authors.initials: CM
authors.lastname: Morshead
mesh_terms: D002454:Cell Differentiation; D016543:Central Nervous System Neoplasms / Q000473:pathology / Q000628:therapy; D006801:Humans; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*