title: SAPHO syndrome with a tumour-like bony proliferative lesion in distal femur. A case report.
abstract: SAPHO syndrome is a group of bone and joint abnormalities associated with skin lesions. A 29-year-old male presented with severe acne on his trunk and anterior chest wall, right knee and foot pain. Radiographs and magnetic resonance images showed hyperostosis in the sternocostoclavicular region, sclerosis of one-third of the right distal 5th metatarsal bone and bony outgrowth from the medial condyle of the right femur. The histological findings of the biopsy specimen were consistent with-those of old osteomyelitis. All fungal and microbacterial cultures were negative. Pain and swelling of the right knee and foot repeated remission and aggravation. There were no radiological changes of the above-mentioned lesions noted within 4-years follow-up.
authors.affiliation: Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Munenori
authors.initials: M
authors.lastname: Watanuki
authors.forename: Masahito
authors.initials: M
authors.lastname: Hatori
authors.forename: Shoichi
authors.initials: S
authors.lastname: Kokubun
mesh_terms: D000152:Acne Vulgaris / Q000150:complications; D020083:Acquired Hyperostosis Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D005269:Femur / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography
chemical_list: D015415:Biomarkers