The influence of vagus nerve stimulation on memory.
BACKGROUND
Vagus nerve stimulation (VNS) has been shown to improve memory.


OBJECTIVE
The purpose of this study was to learn at which stage of memory formation this influence occurs.


METHODS
Ten subjects who had been implanted with vagus nerve stimulators for the treatment of intractable seizures performed tasks that assessed learning and retention (Hopkins Verbal Learning Test) during actual and sham VNS.


RESULTS
We found that VNS had no effect on learning but enhanced consolidation, which led to improved retention.


CONCLUSIONS
The means by which VNS improves retention is probably related to the increased activity in the nucleus of the tractus solitarius and the locus coeruleus-central adrenergic system that activates the amygdala and increases long-term potentiation in the hippocampus.
Ghacibeh
Georges A
GA
Department of Neurology, University of Florida, Gainesville, FL 32610-0236, USA. ghacig@neurology.ufl.edu
Shenker
Joel I
JI
Shenal
Brian
B
Uthman
Basim M
BM
Heilman
Kenneth M
KM
D000328:Adult; D004311:Double-Blind Method; D004599:Electric Stimulation Therapy; D004827:Epilepsy / Q000523:psychology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D012153:Retention, Psychology / Q000502:physiology*; D017552:Solitary Nucleus / Q000502:physiology; D018709:Statistics, Nonparametric; D014630:Vagus Nerve / Q000502:physiology*