title: Successful treatment of prolonged agranulocytosis caused by acute parvovirus B19 infection with intravenous immunoglobulins.
abstract: A 21-year-old previously healthy male presented with prolonged fever of 3 weeks duration and profound agranulocytosis that did not respond to treatment with granulocyte-stimulating factors. A bone marrow biopsy demonstrated an absence of myeloid lineage. Acute parvovirus B19 infection was diagnosed by the presence of both IgM and IgG anti-parvovirus antibodies. Two days treatment with intravenous immunoglobulins (IVIg) resulted in complete recovery. The role of treatment with immunoglobulins in acute and persistent parvovirus infection is discussed.
authors.affiliation: Department "C" of Internal Medicine, Assaf Harofeh Medical Center, Zerifin 70300, Affiliated to Tel-Aviv University, Israel.
authors.forename: K
authors.initials: K
authors.lastname: Herzog-Tzarfati
authors.forename: E
authors.initials: E
authors.lastname: Shiloah
authors.forename: M
authors.initials: M
authors.lastname: Koren-Michowitz
authors.forename: S
authors.initials: S
authors.lastname: Minha
authors.forename: M J
authors.initials: MJ
authors.lastname: Rapoport