Intracytoplasmic sperm injection (ICSI) in unexplained and stage I endometriosis-associated infertility after fertilization failure with in vitro fertilization (IVF).
OBJECTIVE
To investigate possible differences between unexplained and stage I endometriosis-associated infertility in ICSI cycles conducted after low fertilization (<20%) in preceding IVF cycles with normal semen parameters.


METHODS
Retrospective cohort study consisting of patients with unexplained (n=48) and stage I endometriosis-associated infertility (n=43) with a minimum of one IVF cycle with <20% fertilized oocytes and normal semen quality, treated with ICSI from January 1997 to January 2006. Age matched male factor infertility patients (n=91) were used as controls.


RESULTS
Diploid fertilization rate was significantly lower in the stage I endometriosis-associated infertility group compared to the unexplained infertility group. Score of the transferred embryos, implantation rate, pregnancy rate and outcome were similar in the two groups.


CONCLUSIONS
ICSI appears to be an efficient treatment option after fertilization failure with IVF in unexplained and stage I endometriosis-associated infertility.
Omland
Anne K
AK
Department of Obstetrics and Gynaecology, Rikshospitalet-Radiumhospitalet Medical Center, Sognsvannsveien 20, 0027, Oslo, Norway. anne.omland@rikshospitalet.no
Bjercke
Sverre
S
Ertzeid
Gudvor
G
Fedorcsák
Peter
P
Oldereid
Nan B
NB
Storeng
Ritsa
R
Abyholm
Thomas
T
Tanbo
Tom
T
D000328:Adult; D000704:Analysis of Variance; D015331:Cohort Studies; D004715:Endometriosis / Q000150:complications*; D005069:Evaluation Studies as Topic; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000209:etiology* / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome