Decreased plasma adiponectin concentration in major depression.
Adiponectin is the most abundant adipose-derived plasma protein. Recently adiponectin levels have been linked to most variables of metabolic syndrome and conventional risk factors for cardiovascular disease. However, its relation with major depression is yet unclear. We evaluated plasma adiponectin levels in 32 first-episode drug-naïve major depression (DSM-IV-TR) patients without conventional risk factors for cardiovascular disease and 32 matched healthy subjects. Major depression patients displayed lower adiponectin plasma levels compared to controls (P<0.01). Adiponectin significantly correlated with depression severity, as assessed by HAM-D (rho=0.83, P<0.001). This study shows decreased plasma adiponectin concentrations in major depression patients and relates adiponectinemia reduction to major depression severity.
Leo
Roberto
R
Department of Internal Medicine, University of Rome Tor Vergata, School of Medicine, Rome, Italy. rtoleo@tiscali.it
Di Lorenzo
Giorgio
G
Tesauro
Manfredi
M
Cola
Clarissa
C
Fortuna
Enzo
E
Zanasi
Marco
M
Troisi
Alfonso
A
Siracusano
Alberto
A
Lauro
Renato
R
Romeo
Francesco
F
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D003865:Major Depressive Disorder / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index
D052242:Adiponectin