title: [Sensitization to Lyral].
abstract: BACKGROUND
  Lyral is a fragrance that is present in many cosmetic products. It has turned into an emergent allergen during the last years. In studies carried out in other European countries, the prevalence of sensitization to Lyral has been found to be 1.9-2.7 %, but it is unknown the prevalence in Spain, as well as the need to include it or not in the standard series of the Spanish Group of Contact Dermatitis (GEIDC).
  
  
  METHODS
  We have patch-tested to Lyral all patients with suspicion of contact dermatitis of any origin who attended our Service between April and May-2005.
  
  
  RESULTS
  From a total of 170 patients included in our study, 2 of them had a sensitization to Lyral (1.2 %). One of these two patients had an axillae contact dermatitis caused by a deodorant containing Lyral. The other patient was a masseur-woman with a contact dermatitis on both hands, with periods of dissemination to upper extremities and trunk, and who used several cosmetics products for private reasons and during her job.
  
  
  CONCLUSIONS
  Although the sample of this study is quite small, we think that the results allow to suspect that Lyral is one of the main allergens, or even the most important, in causing allergic contact dermatitis to fragrances in our environment. Therefore, we believe that we must raise the inclusion of Lyral in the standard series of GEIDC, either as independent allergen, or including it in a new mixture of fragrances.
authors.affiliation: Servicio de Dermatología Laboral, Instituto de Salud Carlos III, Madrid, España. felipeheras@yahoo.com
authors.forename: F
authors.initials: F
authors.lastname: Heras
authors.forename: J L
authors.initials: JL
authors.lastname: Díaz-Recuero
authors.forename: M J
authors.initials: MJ
authors.lastname: Cabello
authors.forename: L
authors.initials: L
authors.lastname: Conde-Salazar
mesh_terms: D000328:Adult; D000447:Aldehydes / Q000009:adverse effects*; D053138:Cyclohexenes / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010476:Perfume / Q000009:adverse effects*; D015995:Prevalence
chemical_list: D000447:Aldehydes; D053138:Cyclohexenes; D010476:Perfume; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde