Low-dose growth hormone treatment (0.175 mg/kg/week) for short stature in patients with Turner Syndrome: data from KIGS Japan.
Turner syndrome is a common sex chromosome anomaly. Human growth hormone (hGH) is effective for treating short stature, which is a major characteristic of the disease. In this report, we analyzed the results of low-dose GH treatment for short stature in 212 Turner syndrome patients with growth hormone deficiency. These patients were enrolled in KIGS Japan. After 5 years of treatment, change in height was more than the mean growth curve in many patients, and the standard deviation (SD) for stature improved by +1.22 SDS. As the treatment progressed, the weight-for-height index (WHI) decreased in patients aged 8.1 years or older but not more than 14.8 years at the commencement of the treatment.
Ito
Yoshiya
Y
Japanese Red Cross Hokkaido College of Nursing, Kitami, Japan.
Fujieda
Kenji
K
Tanaka
Toshiaki
T
Takano
Kazue
K
Chihara
Kazuo
K
Seino
Yoshiki
Y
Irie
Minoru
M
D000293:Adolescent; D000328:Adult; D001827:Body Height / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004393:Dwarfism, Pituitary / Q000188:drug therapy; D005260:Female; D019382:Human Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D007564:Japan; D012189:Retrospective Studies; D014424:Turner Syndrome / Q000188:drug therapy*
D019382:Human Growth Hormone