title: The need for speed: an update on methamphetamine addiction.
abstract: The psychostimulant methamphetamine (MA) is a highly addictive drug that has surged in popularity over the last decade in North America. A burgeoning number of clandestine drug laboratories has led to dramatic increases in MA production, which have resulted in significant public health, legal and environmental problems. Current evidence indicates that exposure to MA is neurotoxic, and neuroimaging studies confirm that long-term use in humans may lead to extensive neural damage. These physiological changes are commonly associated with persistent forms of cognitive impairment, including deficits in attention, memory and executive function. In the present review, we provide a comprehensive description of the factors relating to MA use and the major health-related consequences, with an emphasis on MA-induced psychosis. It is hoped that increased knowledge of MA abuse will provide the basis for future treatment strategies.
authors.affiliation: Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. albarr@interchange.ubc.ca
authors.forename: Alasdair M
authors.initials: AM
authors.lastname: Barr
authors.forename: William J
authors.initials: WJ
authors.lastname: Panenka
authors.forename: G William
authors.initials: GW
authors.lastname: MacEwan
authors.forename: Allen E
authors.initials: AE
authors.lastname: Thornton
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Lang
authors.forename: William G
authors.initials: WG
authors.lastname: Honer
authors.forename: Tania
authors.initials: T
authors.lastname: Lecomte
mesh_terms: D019969:Amphetamine-Related Disorders / Q000150:complications* / Q000453:epidemiology; D000818:Animals; D001921:Brain / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D003072:Cognition Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004195:Disease Models, Animal; D006801:Humans; D008694:Methamphetamine / Q000633:toxicity*; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine