title: Mid-latency auditory-evoked responses and sensory gating in focal epilepsy: a preliminary exploration.
abstract: The relationship between epilepsy and psychosis is not well defined. Sensory gating is a possible endophenotype for psychosis, and has not been fully examined in epileptic patients. The authors examined 29 patients with focal epilepsy who were on antiepileptic medications, and 29 age-matched healthy comparison subjects, using a paired-stimulus (S1-S2) paradigm. P50 and N100 amplitudes or gating did not differ between the groups. The P200 was significantly smaller and did not gate as well in epileptic patients. Though alteration of sensory gating can be demonstrated in epileptic patients, it seems to be qualitatively different from alterations reported in association with schizophrenia.
authors.affiliation: Wayne State University School of Medicine, Department of Psychiatry and Behavioral Neurosciences, Detroit, MI 48207, USA. nboutros@med.wayne.edu
authors.forename: Nash N
authors.initials: NN
authors.lastname: Boutros
authors.forename: Peter
authors.initials: P
authors.lastname: Trautner
authors.forename: Oleg
authors.initials: O
authors.lastname: Korzyukov
authors.forename: Thomas
authors.initials: T
authors.lastname: Grunwald
authors.forename: Scott
authors.initials: S
authors.lastname: Burroughs
authors.forename: Christian E
authors.initials: CE
authors.lastname: Elger
authors.forename: Martin
authors.initials: M
authors.lastname: Kurthen
authors.forename: Timm
authors.initials: T
authors.lastname: Rosburg
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000503:physiopathology* / Q000523:psychology*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000523:psychology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales