The effect of cancer treatment on female fertility and strategies for preserving fertility.
Aggressive chemotherapy and radiotherapy in young patients with cancer has greatly enhanced the life expectancy of these patients, but these treatments often cause infertility because of the massive destruction of the ovarian reserve resulting in premature ovarian failure (POF). This review focuses on the effect of cancer treatments on fertility and on the various surgical and assisted-reproduction innovations that are available to provide the patient with the option of future pregnancies. As the emerging discipline of fertility preservation is steadily attracting increasing interest, developments in the near future promise to be very exciting. However, in everyday routine work, better interdisciplinary cooperation between gynecological and pediatric oncologists, surgeons, immunologists and endocrinologists is necessary so that individualized options for fertility preservation can be offered in advance of surgical procedures or cancer treatments. GnRH analog treatment can preserve fertility in some patients, but not in all. At present, cryopreservation of ovarian tissue appears as a very promising method of providing the cancer patient with a realistic chance of preserving fertility-a prospect that is also extremely important to patients for psychological reasons.
Maltaris
Theodoros
T
Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany. maltaris@uni-mainz.de
Seufert
Rudolf
R
Fischl
Franz
F
Schaffrath
Michael
M
Pollow
Kunhard
K
Koelbl
Heinz
H
Dittrich
Ralf
R
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D015925:Cryopreservation; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000517:prevention & control* / Q000628:therapy; D009369:Neoplasms / Q000628:therapy; D009865:Oocytes; D010053:Ovary; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced; D011832:Radiation Injuries; D027724:Reproductive Techniques, Assisted
D000970:Antineoplastic Agents; D007987:Gonadotropin-Releasing Hormone