Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata.
A new 2-arylbenzofuran, puerariafuran (1), as well as three known compounds, coumestrol (2), daidzein (3), and genistein (4), were isolated from a MeOH extract of the roots of Pueraria lobata as active constituents, using an in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structure of 1 was determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates (1-4) were evaluated for the inhibitory activity on AGEs formation in vitro.
Jang
Dae Sik
DS
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Yuseong-gu, Daejon 305-811, Korea.
Kim
Jong Min
JM
Lee
Yun Mi
YM
Kim
Young Sook
YS
Kim
Joo-Hwan
JH
Kim
Jin Sook
JS
D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology*; D003375:Coumestrol / Q000737:chemistry / Q000302:isolation & purification; D019833:Genistein / Q000737:chemistry / Q000302:isolation & purification; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D006031:Glycosylation; D066298:In Vitro Techniques; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry*; D012015:Reference Standards; D013237:Stereoisomerism
D001572:Benzofurans; D017127:Glycation End Products, Advanced; D007529:Isoflavones; C514034:puerariafuran; C004742:daidzein; D019833:Genistein; D003375:Coumestrol