title: Structural brain abnormalities in juvenile myoclonic epilepsy patients: volumetry and voxel-based morphometry.
abstract: OBJECTIVE
  We aimed to find structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients.
  
  
  METHODS
  The volumes of the cerebrum, hippocampus and frontal lobe and the area of the corpus callosum's subdivisions were all semiautomatically measured, and then optimized voxel-based morphometry (VBM) was performed in 19 JME patients and 19 age/gender matched normal controls.
  
  
  RESULTS
  The rostrum and rostral body of the corpus callosum and the left hippocampus were significantly smaller than those of the normal controls, whereas the volume of the JME's left frontal lobe was significantly larger than that of the controls. The area of the rostral body had a significant positive correlation with the age of seizure onset (r = 0.56, p = 0.012), and the volume of the right frontal lobe had a significant negative correlation with the duration of disease (r = -0.51, p = 0.025). On the VBM, the gray matter concentration of the prefrontal lobe (bilateral gyri rectus, anterior orbital gyri, left anterior middle frontal gyrus and right anterior superior frontal gyrus) was decreased in the JME group (corrected p < 0.05).
  
  
  CONCLUSIONS
  The JME patients showed complex structural abnormalities in the corpus callosum, frontal lobe and hippocampus, and also a decreased gray matter concentration of the prefrontal region, which all suggests there is an abnormal neural network in the JME brain.
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Tae
authors.forename: Seung Bong
authors.initials: SB
authors.lastname: Hong
authors.forename: Eun Yun
authors.initials: EY
authors.lastname: Joo
authors.forename: Sun Jung
authors.initials: SJ
authors.lastname: Han
authors.forename: Jae-Wook
authors.initials: JW
authors.lastname: Cho
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Seo
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: In Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Hong Sik
authors.initials: HS
authors.lastname: Byun
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000473:pathology*; D009929:Organ Size; D012815:Signal Processing, Computer-Assisted