title: Tacrolimus (Pan Graf) as de novo therapy in renal transplant recipients in India.
abstract: The safety and efficacy of tacrolimus in transplantation is well established. However, tacrolimus has only recently been available in India. We report an initial experience using tacrolimus as de novo therapy in a living related renal transplant program. Fifty-two consecutive recipients of living renal allografts were treated with tacrolimus, mycophenolate mofetil, or azathioprine and steroids. The dose of tacrolimus was adjusted to keep trough levels at 10 to 12 ng/mL in the first 3 months, 8 to 10 ng/mL in the next 3 months, and 5 to 8 ng/mL thereafter. Any evidence of graft dysfunction was evaluated by graft biopsy. The effect of this regimen on the lipid profile as well as the incidence of posttransplant diabetes mellitus was evaluated in an Indian population. All patients were followed for periods ranging from 6 to 72 weeks (mean = 29 weeks). The incidence of acute rejection was 3.84%; 17.3% developed posttransplant diabetes mellitus. Graft and patient survivals at the current follow-up were 100% and 96.26%. In conclusion, tacrolimus is a safe and effective immunosuppressant in a living related renal transplant program.
authors.affiliation: Department of Surgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. sandeepguleria@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Guleria
authors.forename: M
authors.initials: M
authors.lastname: Kamboj
authors.forename: P
authors.initials: P
authors.lastname: Singh
authors.forename: M
authors.initials: M
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Pandey
authors.forename: A
authors.initials: A
authors.lastname: Chatterjee
authors.forename: A K
authors.initials: AK
authors.lastname: Dinda
authors.forename: S
authors.initials: S
authors.lastname: Mahajan
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: D
authors.initials: D
authors.lastname: Bhowmik
authors.forename: S K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: S C
authors.initials: SC
authors.lastname: Tiwari
authors.forename: S C
authors.initials: SC
authors.lastname: Dash
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007194:India; D016030:Kidney Transplantation / Q000276:immunology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D008055:Lipids; D016559:Tacrolimus