[Epigenetics of the sperm cell].
In addition to genetic information, the spermatozoon carries another type of information, named epigenetic, which is not associated with variations of the DNA sequence. In somatic cells, it is now generally admitted that epigenetic information is not only regulated by DNA methylation but also involves modifications of the genome structure, or epigenome. During male germ cell maturation, the epigenome is globally re-organized, since most histones, which are associated to DNA in somatic cells, are removed and replaced by sperm specific nuclear proteins, the protamines, responsible for the tight compaction of the sperm DNA. However, a small proportion of histones, and probably other proteins, are retained within the sperm nucleus, and the structure of the sperm genome is actually heterogeneous. This heterogeneity of the sperm epigenome could support an epigenetic information, transmitted to the embryo, which could be crucial for its development. Although it is nowadays possible to appreciate the global structure of the sperm genome, the precise constitution of the sperm epigenome remains unknown. In particular, very recent data suggest that specific regions of the genome could be associated with particular proteins and define specific structures. This structural partitioning of the sperm genome could convey important epigenetic information, crucial for the embryo development.
Rousseaux
S
S
Unité Inserm-UJF U309, institut Albert-Bonniot, rond-point de la Chantourne, 38706 La Tronche cedex, France. sophie.rousseaux@ujf-grenoble.fr
Faure
A-K
AK
Thévenon
J
J
Escoffier
E
E
Lestrat
C
C
Govin
J
J
Hennebicq
S
S
Sèle
B
B
Caron
C
C
Khochbin
S
S
D004247:DNA / Q000235:genetics; D044127:Epigenesis, Genetic; D006801:Humans; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D008540:Meiosis; D009154:Mutation; D012098:Reproduction; D013091:Spermatogenesis / Q000235:genetics; D013094:Spermatozoa / Q000737:chemistry
D004247:DNA