title: Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine.
abstract: In patients with bipolar disorder, recent brain imaging studies have reported cingulate cortex volume change. We performed a volumetric magnetic resonance imaging (MRI) study to assess the subregions of the cingulate gyrus; left anterior cingulate (LAC), left posterior cingulate (LPC), right anterior cingulate (RAC), and right posterior cingulate (RPC). Our sample consisted of bipolar patients that are either unmedicated (n=10), on valproate monotherapy (n=10) or on valproate plus quetiapine (n=10) versus healthy comparisons (n=10). Thirty right-handed bipolar disordered patients were recruited. Of them, 10 were first-applying patients who never had taken any drug for this condition (medication-naive group), 10 were on valproate treatment (valproate group) and 10 were on valproate plus quetiapine treatment (valproate plus quetiapine group). Cingulate gyrus volumes included both cortex and white matter. Drug-free patients had significantly smaller LAC and LPC volumes compared with valproate and valproate plus quetiapine groups and healthy controls. In addition, in post hoc comparisons, a trend toward significant difference was found between valproate plus quetiapine group and valproate group in regard to only LAC. Our findings suggest that valproate and quetiapine may have neuroprotective effects.
authors.affiliation: Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey. matmaca_p@yahoo.com
authors.forename: Murad
authors.initials: M
authors.lastname: Atmaca
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ozdemir
authors.forename: Sebnem
authors.initials: S
authors.lastname: Cetinkaya
authors.forename: Serap
authors.initials: S
authors.lastname: Parmaksiz
authors.forename: Hasan
authors.initials: H
authors.lastname: Belli
authors.forename: A Kursad
authors.initials: AK
authors.lastname: Poyraz
authors.forename: Ertan
authors.initials: E
authors.lastname: Tezcan
authors.forename: Erkin
authors.initials: E
authors.lastname: Ogur
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D004292:Dominance, Cerebral / Q000502:physiology; D004359:Drug Therapy, Combination; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D000069348:Quetiapine Fumarate; D013223:Statistics as Topic; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D014635:Valproic Acid