[Effect of resveratrol on the cognitive ability of Alzheimeros mice].
OBJECTIVE
To explore the effect of resveratrol on the cognition of Alzheimer's mice (AD) and its mechanism, and to assess its action on the reproduction system.


METHODS
According to the results of step-down test, 84 Kunming female mice were randomly divided into 6 groups: Group A [sham operated+1% CMC-Na (0.01 mL/g)], Group B [ovariectomy+D-galactose+1% CMC-Na (0.01 mL/g)], Group C [ovariectomy+D-galactose+0.05 mg/(kg.d) Diethylstilbestrol], Group D [ovariectomy+D-galactose+15 mg/(kg.d) Res], and Group E [ovariectomy+D-galactose injected+45 mg/(kg.d) Res], and Group F [ovariectomy+D-galactose +135 mg/(kg.d) Res]. Experimental cycle was 60 days.


RESULTS
Resveratrol of every dosage could improve the performance records of behavior tests in AD mice,could inhibit the SOD vitality and the MDA level both in the serum and in the brain, and could suppress the acetylcholinesterase vitality and the bax expression. Resveratrol has no endometrial hyperplasia effect.


CONCLUSIONS
Resveratrol can improve the cognitive ability of AD mice, which may contribute to the resveratrol's antioxidation and antiapoptosis, and can modulate acetylcholinesterase. Resveratrol has no side-effect of endometrial hyperplasia on AD mice.
Luo
Li
L
Deparment of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078, China.
Huang
Yi-ming
YM
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D005260:Female; D005690:Galactose; D051379:Mice; D010052:Ovariectomy; D011897:Random Allocation; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol; D005690:Galactose