title: Ethical issues in critical care and cardiac arrest: clinical research, brain death, and organ donation.
abstract: Cardiac arrest results in global hypoxic-ischemic brain injury from which there is a range of possible neurological outcomes. In most cases, patients may require a surrogate to make decisions regarding end-of-life care, including the withdrawal of life-sustaining therapies. This article reviews ethical considerations that arise in the clinical care of patients following cardiac arrest, including decisions to continue or withdraw life-sustaining therapies; brain death determination; and organ donation in the context of brain death and cardiac death (so-called non-heart-beating donation). This article also discusses ethical concerns pertaining to the design and conduct of resuscitation research that is necessary for the development of effective therapies to prevent anoxic brain injury or promote neurological recovery.
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Luke A
authors.initials: LA
authors.lastname: Donatelli
authors.forename: Romergryko G
authors.initials: RG
authors.lastname: Geocadin
authors.forename: Michael A
authors.initials: MA
authors.lastname: Williams
mesh_terms: D016223:Advance Directives / Q000706:statistics & numerical data / Q000639:trends; D035843:Biomedical Research / Q000941:ethics / Q000331:legislation & jurisprudence / Q000639:trends; D001926:Brain Death / Q000175:diagnosis* / Q000331:legislation & jurisprudence / Q000503:physiopathology; D017028:Caregivers / Q000706:statistics & numerical data / Q000639:trends; D006323:Heart Arrest / Q000150:complications*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D007258:Informed Consent / Q000331:legislation & jurisprudence / Q000706:statistics & numerical data; D012151:Resuscitation / Q000941:ethics / Q000592:standards / Q000639:trends; D016414:Resuscitation Orders / Q000941:ethics* / Q000331:legislation & jurisprudence; D009927:Tissue and Organ Procurement / Q000941:ethics* / Q000331:legislation & jurisprudence / Q000639:trends