Molecular differentiation of Treponema pallidum subspecies.
Treponema pallidum includes three subspecies of antigenically highly related treponemes. These organisms cause clinically distinct diseases and cannot be distinguished by any existing test. In this report, genetic signatures are identified in two tpr genes which, in combination with the previously published signature in the 5' flanking region of the tpp15 gene, can differentiate the T. pallidum subspecies, as well as a simian treponeme.
Centurion-Lara
Arturo
A
Department of Medicine, University of Washington, Seattle, 98195, USA. acentur@u.washington.edu
Molini
Barbara J
BJ
Godornes
Charmie
C
Sun
Eileen
E
Hevner
Karin
K
Van Voorhis
Wesley C
WC
Lukehart
Sheila A
SA
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D001483:Base Sequence; D004269:DNA, Bacterial / Q000032:analysis; D006801:Humans; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D011817:Rabbits; D013045:Species Specificity; D013587:Syphilis / Q000382:microbiology; D014210:Treponema pallidum / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D014211:Treponemal Infections / Q000382:microbiology
D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; C406409:Tpr protein, Treponema