Probing structural effects on replication efficiency through comparative analyses of families of potential self-replicators.
A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self-replication). In order to achieve this goal, a detailed understanding of the relationship between molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally-related systems reveals the key determinants that dictate the emergence of self-replicative function and defines the structural space within which this behaviour is observed.
Kassianidis
Eleftherios
E
Centre for Biomolecular Sciences, School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK.
Pearson
Russell J
RJ
Philp
Douglas
D
D002384:Catalysis; D002725:Chloroform / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003903:Deuterium / Q000737:chemistry; D019281:Dimerization; D005663:Furans / Q000737:chemistry; D007700:Kinetics; D046911:Macromolecular Substances / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008433:Mathematics; D008956:Models, Chemical; D013237:Stereoisomerism; D013816:Thermodynamics
D005663:Furans; D046911:Macromolecular Substances; D002725:Chloroform; D003903:Deuterium; C039281:furan