Therapeutic application of long-circulating liposomal glucocorticoids in auto-immune diseases and cancer.
Glucorticoids are potent drugs that have a multitude of pharmacological actions both at genomic and non-genomic levels. Many of the diseases in which glucorticoids are routinely administered are featured by angiogenesis and enhanced capillary permeability, permitting targeted delivery using long-circulating drug delivery systems. By encapsulation of glucorticoids in long-circulating liposomes, drug levels at the site of the pathology are markedly higher, increasing and prolonging therapeutic efficacy in models of rheumatoid arthritis, multiple sclerosis, and cancer.
Schiffelers
Raymond M
RM
Dept. Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. R.M.Schiffelers@pharm.uu.nl
Banciu
Manuela
M
Metselaar
Josbert M
JM
Storm
Gert
G
D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D006801:Humans; D008081:Liposomes; D009369:Neoplasms / Q000097:blood*
D005938:Glucocorticoids; D008081:Liposomes