A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13.
The authors investigated genetic factors contributing to restless legs syndrome (RLS) by performing a 10-cM genome-wide scan in a large French-Canadian pedigree. They detected an autosomal-dominant locus mapping to chromosome 20p13, with a maximum multipoint lod score of 3.86 at marker D20S849. This is the third reported autosomal-dominant locus for RLS and the first autosomal-dominant RLS locus in the French-Canadian population.
Levchenko
A
A
Center for the Study of Brain Diseases, CHUM Research Center-Notre Dame Hospital, Montreal, Quebec, Canada.
Provost
S
S
Montplaisir
J Y
JY
Xiong
L
L
St-Onge
J
J
Thibodeau
P
P
Rivière
J B
JB
Desautels
A
A
Turecki
G
G
Dubé
M P
MP
Rouleau
G A
GA
D002874:Chromosome Mapping / Q000379:methods*; D002890:Chromosomes, Human, Pair 20; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D012148:Restless Legs Syndrome / Q000235:genetics*