title: Phosphine-catalyzed alpha-P-addition on activated alkynes: A new route to P-C-P backbones.
abstract: n-Tributylphosphine was found to efficiently catalyze the alpha-P addition of H-phosphonates, H-phosphinates, and H-phosphine oxide pronucleophiles on alkynes bearing phosphane oxide activating moieties. The reaction leads to 2-aryl-1-vinyl-1,1-diphosphane dioxide derivatives in good yields affording a new route to P-C-P backbones. The products of this reaction are easily converted to biologically important 1,1-bis-phosphonates analogues.
authors.affiliation: Service de Marquage Moléculaire et de Chimie Bioorganique, Commissariat à l'Energie Atomique, Gif sur Yvette, F-91191 France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Lecerclé
authors.forename: Marcin
authors.initials: M
authors.lastname: Sawicki
authors.forename: Frédéric
authors.initials: F
authors.lastname: Taran
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D010720:Phosphines / Q000737:chemistry*
chemical_list: D000480:Alkynes; D010720:Phosphines