Quorum sensing-disrupting brominated furanones protect the gnotobiotic brine shrimp Artemia franciscana from pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates.
Autoinducer 2 (AI-2) quorum sensing was shown before to regulate the virulence of Vibrio harveyi towards the brine shrimp Artemia franciscana. In this study, several different pathogenic V. harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates were shown to produce AI-2. Furthermore, disruption of AI-2 quorum sensing by a natural and a synthetic brominated furanone protected gnotobiotic Artemia from the pathogenic isolates in in vivo challenge tests.
Defoirdt
Tom
T
Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653, 9000 Ghent, Belgium.
Crab
Roselien
R
Wood
Thomas K
TK
Sorgeloos
Patrick
P
Verstraete
Willy
W
Bossier
Peter
P
D000818:Animals; D001156:Artemia / Q000187:drug effects / Q000382:microbiology*; D005663:Furans / Q000737:chemistry / Q000494:pharmacology; D005856:Germ-Free Life; D006714:Homoserine / Q000031:analogs & derivatives / Q000378:metabolism; D007783:Lactones / Q000378:metabolism; D013045:Species Specificity; D014733:Vibrio / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*; D014736:Vibrio parahaemolyticus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*
D005663:Furans; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine