title: Expressions of the VLA-4, LFA-1 and Mac-1 integrins in eosinophil migration in a case of chronic eosinophilic leukaemia.
abstract: Migration of eosinophil (Eo) into tissues is a hallmark of chronic eosinophilic leukaemia (CEL), but the exact mechanism involved in cell migration is unknown. We report on a patient with CEL who presented high expressions of VLA-4, LFA-1 and Mac-1 integrins on the Eo surface, increased chemotaxis of Eo to eotaxin, decreased chemotaxis of Eo after inhibition of the cyclic guanosine monophosphate (cGMP), and a high level of intracellular cGMP. These findings suggest that an upregulation of expression of these integrins on Eo surface and a high intracellular level of cGMP may be involved in the increased Eo migration observed in our CEL patient. However, the definitive roles of these molecules in the proliferation and migration of Eo in CEL disease require wider confirmation by analysis of additional patients with the disease.
authors.affiliation: Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Cidade Universitária Zeferino Vaz, Rua Alexander Flemming no. 181, Barão Geraldo, Campinas, São Paulo, CEP 13083-970, Brazil. carmen1@fcm.unicamp.br
authors.forename: Carmen S P
authors.initials: CS
authors.lastname: Lima
authors.forename: Carla F
authors.initials: CF
authors.lastname: Franco-Penteado
authors.forename: Andreia A
authors.initials: AA
authors.lastname: Canalli
authors.forename: Nicola
authors.initials: N
authors.lastname: Conran
authors.forename: Irene
authors.initials: I
authors.lastname: Lorand-Metze
authors.forename: Fernando F
authors.initials: FF
authors.lastname: Costa
authors.forename: Heloisa H A
authors.initials: HH
authors.lastname: Ferreira
mesh_terms: D002465:Cell Movement; D002631:Chemotactic Factors, Eosinophil; D002634:Chemotaxis, Leukocyte; D002908:Chronic Disease; D004804:Eosinophils / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D039041:Integrin alpha4beta1 / Q000378:metabolism*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*; D016177:Macrophage-1 Antigen / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D002631:Chemotactic Factors, Eosinophil; D039041:Integrin alpha4beta1; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen