Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis.
In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.
Arung
Enos Tangke
ET
Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Shimizu
Kuniyoshi
K
Kondo
Ryuichiro
R
D000363:Agaricales / Q000201:enzymology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D047309:Flavones / Q000494:pharmacology*; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000378:metabolism; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000494:pharmacology
D000975:Antioxidants; D004791:Enzyme Inhibitors; D047309:Flavones; D008543:Melanins; D010936:Plant Extracts; C513884:artocarpanone; D014442:Monophenol Monooxygenase