title: Observation of anomalous diffusion in excised tissue by characterizing the diffusion-time dependence of the MR signal.
abstract: This report introduces a novel method to characterize the diffusion-time dependence of the diffusion-weighted magnetic resonance (MR) signal in biological tissues. The approach utilizes the theory of diffusion in disordered media where two parameters, the random walk dimension and the spectral dimension, describe the evolution of the average propagators obtained from q-space MR experiments. These parameters were estimated, using several schemes, on diffusion MR spectroscopy data obtained from human red blood cell ghosts and nervous tissue autopsy samples. The experiments demonstrated that water diffusion in human tissue is anomalous, where the mean-square displacements vary slower than linearly with diffusion time. These observations are consistent with a fractal microstructure for human tissues. Differences observed between healthy human nervous tissue and glioblastoma samples suggest that the proposed methodology may provide a novel, clinically useful form of diffusion MR contrast.
authors.affiliation: STBB/LIMB/NICHD, National Institutes of Health, Bethesda, MD 20892, USA. evren@helix.nih.gov
authors.forename: Evren
authors.initials: E
authors.lastname: Ozarslan
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Basser
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Shepherd
authors.forename: Peter E
authors.initials: PE
authors.lastname: Thelwall
authors.forename: Baba C
authors.initials: BC
authors.lastname: Vemuri
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Blackband
mesh_terms: D000465:Algorithms; D001834:Body Water / Q000378:metabolism*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*