title: Using addiction severity profiles to differentiate cocaine-dependent patients with and without comorbid major depression.
abstract: This study compared pretreatment addiction severity profiles of 339 abusers in three diagnostic groups: cocaine dependence only (CO), cocaine dependence with substance-induced major depression (SIMD), and cocaine dependence with independent major depression (IMD). Depressed subjects reported more severe problems than non-depressed subjects across numerous domains, regardless of diagnostic etiology. These findings support the need for specialized treatment approaches targeting depressive symptoms or life stress for cocaine-dependent patients with IMD or SIMD, though patients with IMD may require additional attention for chronic and comorbid psychiatric and medical problems.
authors.affiliation: Department of Psychology, the University of Houston, Houston, Texas 77204-5022, USA. aleventhal@uh.edu
authors.forename: Adam M
authors.initials: AM
authors.lastname: Leventhal
authors.forename: Marc E
authors.initials: ME
authors.lastname: Mooney
authors.forename: Katherine A
authors.initials: KA
authors.lastname: DeLaune
authors.forename: Joy M
authors.initials: JM
authors.lastname: Schmitz
mesh_terms: D000328:Adult; D003042:Cocaine / Q000009:adverse effects*; D019970:Cocaine-Related Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000139:chemically induced / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D017831:Diagnosis, Dual (Psychiatry); D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D020380:Needs Assessment / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: D003042:Cocaine