title: Numerical equivalence of imputing scores and weighted estimators in regression analysis with missing covariates.
abstract: Imputation, weighting, direct likelihood, and direct Bayesian inference (Rubin, 1976) are important approaches for missing data regression. Many useful semiparametric estimators have been developed for regression analysis of data with missing covariates or outcomes. It has been established that some semiparametric estimators are asymptotically equivalent, but it has not been shown that many are numerically the same. We applied some existing methods to a bladder cancer case-control study and noted that they were the same numerically when the observed covariates and outcomes are categorical. To understand the analytical background of this finding, we further show that when observed covariates and outcomes are categorical, some estimators are not only asymptotically equivalent but also actually numerically identical. That is, although their estimating equations are different, they lead numerically to exactly the same root. This includes a simple weighted estimator, an augmented weighted estimator, and a mean-score estimator. The numerical equivalence may elucidate the relationship between imputing scores and weighted estimation procedures.
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. cywang@fhcrc.org
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
authors.forename: Shen-Ming
authors.initials: SM
authors.lastname: Lee
authors.forename: Edward C
authors.initials: EC
authors.lastname: Chao
mesh_terms: D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D006801:Humans; D009765:Obesity / Q000473:pathology; D012044:Regression Analysis; D012907:Smoking / Q000009:adverse effects; D001749:Urinary Bladder Neoplasms / Q000209:etiology; D014861:Washington