title: Definition and current evaluation of subfertile men.
abstract: Male infertility affects 10% of reproductive aged couples worldwide and is treatable in many cases. In addition to other well-described etiologies, genetic causes of male infertility are now more commonly diagnosed. Using principles of evidence-based medicine, this review outlines diagnostic and treatments options to inform clinical management. In order of importance, randomized controlled clinical trials, basic scientific studies, meta-analyses, case-controlled cohort studies, best-practice policy recommendations and reviews from peer-reviewed literature were incorporated that provide organized and timely guidelines to the current management of male infertility. The strength of evidence for treatment recommendations is also classified when appropriate.
authors.affiliation: Department of Urology, University of California San Francisco, San Francisco, California 94143-1695, USA.
authors.forename: Shai
authors.initials: S
authors.lastname: Shefi
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Turek
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008297:Male