title: Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents.
abstract: A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown > 94% inhibition against promastigotes at a concentration of 10 microg/mL.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Naresh
authors.initials: N
authors.lastname: Sunduru
authors.forename: Anu
authors.initials: A
authors.lastname: Agarwal
authors.forename: Sanjay Babu
authors.initials: SB
authors.lastname: Katiyar
authors.lastname: Nishi
authors.forename: Neena
authors.initials: N
authors.lastname: Goyal
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
authors.forename: Prem M S
authors.initials: PM
authors.lastname: Chauhan
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000138:chemical synthesis*
chemical_list: D006571:Heterocyclic Compounds; D011743:Pyrimidines; D014227:Triazines; D014344:Trypanocidal Agents