title: Pulmonary relapse of non-Hodgkin's lymphoma in bilateral upper lobes.
abstract: We describe a 68-year-old male patient with diffuse large B-cell lymphoma (DLBCL) who suffered from relapse in bilateral upper lobes of the lung. The patient presented with cough, weakness and fever. A bronchovascular-lymphangitis-like shadow was detected in the bilateral upper lobes on a chest roentgenogram. Although cytological and cytofluorometric examinations revealed no malignant cells in the bronchoalveolar lavage fluid, trans-bronchial lung biopsy (TBLB) showed involvement of DLBCL in the bronchial mucosa. Recurrent lymphoma tends to extend along the bronchovascular bundles, resulting in granulomatous consolidation that may mimic tuberculosis and is likely to involve the lower lobes. Thus, TBLB proved to be essential for the diagnosis of the lung involvement of non-Hodgkin's lymphoma (NHL).
authors.affiliation: Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto,Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nomura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shimizu
authors.forename: Takashi
authors.initials: T
authors.lastname: Okuda
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yoshida
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Taki
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horiike
authors.forename: Masafumi
authors.initials: M
authors.lastname: Taniwaki
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D014376:Tuberculosis / Q000175:diagnosis