Susceptibilities of Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime.
We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 microg/ml to 0.75 microg/ml, 0.094 microg/ml to 1.5 microg/ml, and 1 microg/ml to 12 microg/ml for ertapenem, meropenem, and cefepime, respectively. Based on our excellent in vitro carbapenem susceptibility results, in vivo studies using ertapenem and meropenem in a rabbit model of P. acnes endophthalmitis are warranted.
Shames
Robert
R
Division of Infectious Disease, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11042, USA.
Satti
Farhana
F
Vellozzi
Ernestine M
EM
Smith
Miriam A
MA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D000077727:Ertapenem; D005123:Eye / Q000382:microbiology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000187:drug effects*; D011817:Rabbits; D013845:Thienamycins / Q000494:pharmacology*; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013845:Thienamycins; D047090:beta-Lactams; D000077723:Cefepime; D000077731:Meropenem; D000077727:Ertapenem