title: Application of the Genotype MTBDR assay directly on sputum specimens.
abstract: The Genotype MTBDR assay was tested for its capability to detect rifampicin (RMP) and isoniazid (INH) resistance (r) and susceptibility (s) directly from 42 smear-positive sputum specimens (15 RMPr/INHr, 2 RMPs/INHr and 25 RMPs/INHs Mycobacterium tuberculosis complex strains). The concordance between the MTBDR assay and conventional drug susceptibility testing was 100%.
authors.affiliation: Forschungszentrum Borstel, Nationales Referenzzentrum für Mykobakterien, Borstel, Germany. dhillemann@fz-borstel.de
authors.forename: D
authors.initials: D
authors.lastname: Hillemann
authors.forename: S
authors.initials: S
authors.lastname: Rüsch-Gerdes
authors.forename: E
authors.initials: E
authors.lastname: Richter
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D005838:Genotype; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics*; D012293:Rifampin / Q000494:pharmacology*; D013183:Sputum / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial; D007538:Isoniazid; D012293:Rifampin