[Regenerative therapy in cardiology: how distant is it from reality?].
During acute myocardial infarction, ischemia causes progressive loss of contractile tissue. Subsequently, structural changes lead to left ventricular remodeling finally resulting in the development of heart failure. In addition to an optimal reperfusion and pharmacologinal post-infarction therapy, increased neovascularization and regeneration of cardiomyocytes could reduce or even abolish the ongoing left ventricular remodeling processes within the infarct area. Experimental studies have demonstrated that transplantation of adult progenitor cells leads to increased neovascularization, reduced fibrosis and, therefore, increased left ventricular function after acute myocardial infarction. In contrast to current treatment strategies, progenitor cell therapy offers a new regenerative approach for myocardial tissue. Initial clinical studies have demonstrated, apart from safety and feasibility of intracoronary infusion of adult autologous progenitor cells, a significant improvement of left ventricular function, geometry and vascularization in patients with acute myocardial infarction receiving intracoronary infusion of progenitor cells. However, in patients with chronic ischemic cardiomyopathy, the improvement in contractility is less pronounced. Finally, whether intracoronary infusion of adult progenitor cells can also reduce morbidity and mortality due to heart failure, remains to be investigated.
Assmus
B
B
Medizinische Klinik III, Kardiologie, Johann-Wolfgang-Goethe-Universität Frankfurt, Frankfurt.
Schächinger
V
V
Zeiher
A M
AM
D053687:Adult Stem Cells / Q000637:transplantation*; D000818:Animals; D002309:Cardiology / Q000639:trends*; D002986:Clinical Trials as Topic / Q000639:trends; D005544:Forecasting; D006801:Humans; D009203:Myocardial Infarction / Q000601:surgery*; D012038:Regeneration; D023822:Tissue Engineering / Q000639:trends*