Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors.
The synthesis of several cyclen based lanthanide [Eu(III) and La(III)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP (an RNA model compound) that is highly dependent on the length of the alkyl spacer.
Fanning
Ann-Marie
AM
School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
Plush
Sally E
SE
Gunnlaugsson
Thorfinnur
T
D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008956:Models, Chemical; D010755:Organophosphates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012333:RNA, Messenger / Q000737:chemistry*
C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D000080027:Cyclams; D006571:Heterocyclic Compounds; D028581:Lanthanoid Series Elements; D010755:Organophosphates; D009943:Organophosphorus Compounds; D012333:RNA, Messenger; C038072:cyclen