title: [Alterations of gonadal axis and sexual steroids concentration in the conditions of intoxication with phenol in the experiments].
abstract: It is known that the male reproduction system is too sensitive to the impact of the environment conditions. One of such endocrine deregulators is phenol. The experiment was held on the 40 adult male albino rats of the mass 200-250 g. Each animal during 15 days was daily experienced intoxication with phenol in the special closed cabin. On the 16th, 30th, 45th and 60th days after the initiation of the experiment we performed decapitation of the animals in conditions of general anesthetic, after what in the blood serum we defined alteration of the concentration of gonadotrope hormones LH, FSH and sexual steroids--testosterone, estrone, estradiol, by means of immune-enzyme method. During the experiment the significant alterations of hormones concentration were revealed, namely, in the mentioned research it was revealed that LH did not stimulate the testosterone secretion, conversely it decreased, while the estrogen concentration increased. The mentioned data gave us basis to conclude that the impact of the phenol vapor caused disorder of the male reproduction function.
authors.forename: E B
authors.initials: EB
authors.lastname: Melikadze
mesh_terms: D000818:Animals; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000378:metabolism; D006066:Gonads / Q000187:drug effects / Q000378:metabolism; D008297:Male; D019800:Phenol / Q000633:toxicity*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
chemical_list: D012739:Gonadal Steroid Hormones; D019800:Phenol