title: State of hypophsis-adrenal gland in conditions of vibration pathology and its correction in experiment.
abstract: Vibration is one of the pathological factors, which causes various alterations in the cells and organs. The goal of the research was the investigation of the hypophysis-adrenal gland system during the vibration and possible methods of its correction. The experiment was held on 70 grown-up male rats from 180 to 200 gr in weight. An hour vibroseance was carried out daily during two months period. According to the means of treatment animals were divided into three groups. The control group was consisted of 10 animals. In the first group (experimental vibratory pathology without any therapy) concentration of AKTH began to increase and reached 154% by the 20th day; by the 40th day it was 130%; AKTH concentration decreased up to 87% by the 60th day. The corticosterone in the blood plasma increased gradually and by the 20th day reached approximately 188%, which by the 40th day gradually decreased to 156%, and by the 60th day it was 129%. The second group was composed of animals, which underwent liquid oxygen therapy after the vibroseance. The AKTH content in the blood plasma of the second group animals was less increased: by the 20th day it reached 134%, by the 40th day it was 117%, and by the 60th day it decreased to 84%. The corticosterone concentration in the second group was lower by the 20th day it was 168%; by the 40th day it reached approximately 143%, and by the 60th day decreased to 127%. The third group was composed of retabolil treated animals. The AKTH concentration in animals by the 20th day reached 206%, and then decreased gradually, and by the 40th day it was 189%, and by the 60th day decreased to 145%. The corticosterone content in the blood plasma was high. By the 20th day the concentration was 263%, then it gradually decreased and by the 40th day reached 242%, and by the 60th day it was 199%. According to the experimental data vibration leads to the activation of hypophysis-adrenal gland system. Increased AKTH initiated increase of corticosterone.
authors.affiliation: Al. Natishvili Institute of Experimental Morphology of Georgian Academy of Sciences, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Kapanadze
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077603:Nandrolone Decanoate; D010100:Oxygen / Q000008:administration & dosage; D010902:Pituitary Gland / Q000187:drug effects / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology*; D051381:Rats; D014732:Vibration
chemical_list: D009277:Nandrolone; D000324:Adrenocorticotropic Hormone; D000077603:Nandrolone Decanoate; D010100:Oxygen; D003345:Corticosterone