Application of palladium-catalyzed allylic arylation to the synthesis of a (+/-)-7-deoxypancratistatin analogue.
Palladium-catalyzed coupling of an aryl siloxane and an allylic carbonate proceeded in good yield to give an adduct that was converted to an analogue of (+/-)-7-deoxypancratistatin.
Shukla
Krupa H
KH
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
Boehmler
Debra J
DJ
Bogacyzk
Suzanne
S
Duvall
Bridget R
BR
Peterson
William A
WA
McElroy
William T
WT
Deshong
Philip
P
D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
C418326:7-deoxypancratistatin; D047151:Amaryllidaceae Alkaloids; D007546:Isoquinolines; D010165:Palladium