title: Acute anuric renal failure secondary to intravenous immunoglobulin in diabetic nephropathy.
abstract: We present a case of acute renal failure in a diabetic patient who received intravenous immunoglobulin therapy. Vigam liquid immunoglobulin was used successfully to treat vancomycin induced toxic epidermal necrolysis, but 4 days later the patient became anuric. Renal function was restored after haemofiltration. Immunoglobulin therapy is used to treat immune-mediated conditions, many of which affect the diabetic population. Renal failure is a rare side effect of immunoglobulin in patients with diabetes and impaired renal function, of which many clinicians are unaware. Caution must be exercised in such patients and the risks of immunoglobulin treatment weighed against the benefits.
authors.affiliation: Department of Diabetes, Royal Gwent Hospital, Newport NP 20 2UB, United Kingdom. Mousumi.Biswas@gwent.wales.nhs.uk
authors.forename: Moushmi
authors.initials: M
authors.lastname: Biswas
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Evans
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000209:etiology*; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous / Q000009:adverse effects; D020127:Recovery of Function; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007136:Immunoglobulins