Readily available phosphine-phosphoramidite ligands for highly efficient Rh-catalyzed enantioselective hydrogenations.
A new family of air- and moisture-stable phosphine-phosphoramidite ligands (PEAPhos) has been prepared from commercially available and inexpensive (S)-alpha-phenylethylamine through a two- or three-step transformation and successfully applied in the rhodium-catalyzed enantioselective hydrogenations of a variety of substrates, in which up to 99.9% ee was obtained for all of these kinds of substrates.
Huang
Jia-Di
JD
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
Hu
Xiang-Ping
XP
Duan
Zheng-Chao
ZC
Zeng
Qing-Hen
QH
Yu
Sai-Bo
SB
Deng
Jun
J
Wang
Dao-Yong
DY
Zheng
Zhuo
Z