title: Synthesis of functionalized 5-imino-2,5-dihydro-furans through the reaction of isocyanides with activated acetylenes in the presence of ethyl bromopyruvate.
abstract: The reaction between alkyl(aryl) isocyanides and dibenzoylacetylene in the presence of ethyl bromopyruvate leads to ethyl 3,4-dibenzoyl-2-bromomethyl-5-alkyl(aryl)imino-2,5-dihydro-furan-2-carboxylates in high yields. Dialkyl acetylenedicarboxylates react with tert-butyl isocyanide and ethyl bromopyruvate to produce 3,4-dialkyl 2-ethyl 2-bromomethyl-5-tert-butylimino-2,5-dihydro-furan-2,3,4-tricarboxylates.
authors.affiliation: Department of Chemistry, Tarbiat Modarres University, Tehran, Iran.yavarisa@modares.ac.ir
authors.forename: Issa
authors.initials: I
authors.lastname: Yavari
authors.forename: Zinatossadat
authors.initials: Z
authors.lastname: Hossaini
authors.forename: Maryam
authors.initials: M
authors.lastname: Sabbaghan
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011773:Pyruvates / Q000737:chemistry; D019289:Pyruvic Acid / Q000737:chemistry
chemical_list: D000480:Alkynes; D003486:Cyanides; D005663:Furans; D011773:Pyruvates; C017092:bromopyruvate; D019289:Pyruvic Acid