Xenobiotic receptor meets NF-kappaB, a collision in the small bowel.
It has long been appreciated that inflammation and infection reduce drug metabolism and that exposure to drug metabolism-inducing xenobiotics can impair immune function. A new study reveals the mutual repression between the xenobiotic nuclear receptor PXR/SXR and NF-kappaB signaling pathways, providing a molecular mechanism linking xenobiotic metabolism and inflammation (Zhou et al.,).
Xie
Wen
W
Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Tian
Yanan
Y
D000818:Animals; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology*; D007249:Inflammation / Q000139:chemically induced / Q000235:genetics / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D016328:NF-kappa B / Q000378:metabolism*; D000077297:Pregnane X Receptor; D011987:Receptors, Steroid / Q000378:metabolism*; D012097:Repressor Proteins / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D015533:Transcriptional Activation / Q000235:genetics / Q000276:immunology; D015262:Xenobiotics / Q000009:adverse effects / Q000276:immunology / Q000378:metabolism*
D018836:Inflammation Mediators; D016328:NF-kappa B; D000077297:Pregnane X Receptor; D011987:Receptors, Steroid; D012097:Repressor Proteins; D015262:Xenobiotics