title: Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI.
abstract: OBJECTIVE
  To examine the neural basis of cognitive complaints in healthy older adults in the absence of memory impairment and to determine whether there are medial temporal lobe (MTL) gray matter (GM) changes as reported in Alzheimer disease (AD) and amnestic mild cognitive impairment (MCI).
  
  
  METHODS
  Participants were 40 euthymic individuals with cognitive complaints (CCs) who had normal neuropsychological test performance. The authors compared their structural brain MRI scans to those of 40 patients with amnestic MCI and 40 healthy controls (HCs) using voxel-based morphometry and hippocampal volume analysis.
  
  
  RESULTS
  The CC and MCI groups showed similar patterns of decreased GM relative to the HC group on whole brain analysis, with differences evident in the MTL, frontotemporal, and other neocortical regions. The degree of GM loss was associated with extent of both memory complaints and performance deficits. Manually segmented hippocampal volumes, adjusted for age and intracranial volume, were significantly reduced only in the MCI group, with the CC group showing an intermediate level.
  
  
  CONCLUSIONS
  Cognitive complaints in older adults may indicate underlying neurodegenerative changes even when unaccompanied by deficits on formal testing. The cognitive complaint group may represent a pre-mild cognitive impairment stage and may provide an earlier therapeutic opportunity than mild cognitive impairment. MRI analysis approaches incorporating signal intensity may have greater sensitivity in early preclinical stages than volumetric methods.
authors.affiliation: Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA. andrew.saykin@dartmouth.edu
authors.forename: A J
authors.initials: AJ
authors.lastname: Saykin
authors.forename: H A
authors.initials: HA
authors.lastname: Wishart
authors.forename: L A
authors.initials: LA
authors.lastname: Rabin
authors.forename: R B
authors.initials: RB
authors.lastname: Santulli
authors.forename: L A
authors.initials: LA
authors.lastname: Flashman
authors.forename: J D
authors.initials: JD
authors.lastname: West
authors.forename: T L
authors.initials: TL
authors.lastname: McHugh
authors.forename: A C
authors.initials: AC
authors.lastname: Mamourian
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000523:psychology*; D000704:Analysis of Variance; D001284:Atrophy; D001931:Brain Mapping; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008569:Memory Disorders / Q000473:pathology* / Q000523:psychology; D009483:Neuropsychological Tests; D014706:Verbal Learning / Q000502:physiology