Effect of mycophenolate mofetil monotherapy on T-cell functions and inosine monophosphate dehydrogenase activity in patients undergoing a kidney transplantation.
The aim of this study was to assess the effects of 1 g of mycophenolate mofetil (MMF) on T-cell function and inosine monophosphate dehydrogenase (IMPDH) activity among patients undergoing kidney transplantation. Five patients undergoing renal transplantation from a living donor were enrolled in this study. Compared to baseline (before MMF intake), CD25 and CD71 expression were significantly decreased during the first hour following MMF intake. T-cell proliferation and IMPDH activity also decreased dramatically. Thereafter, all biomarker levels increased over time. At 4 hours, CD25 and CD71 levels, as well as IMPDH activity, returned to almost baseline values, whereas T-cell proliferation remained below baseline. Intracytoplasmic IL-2 expression remained unchanged after MMF ingestions. In conclusion, administration of 1 g of MMF was associated with a transient decrease in CD25 expression in addition to a temporary dramatic decrease in both T-cell proliferation and IMPDH activity.
Kamar
N
N
Department of Nephrology, Charité Hospital, Berlin, Germany. kamar.n@chu-toulouse.fr
Glander
P
P
Nolting
J
J
Böhler
T
T
Hambach
P
P
Liefeldt
L
L
Neumayer
H-H
HH
Klupp
J
J
Budde
K
K
D015703:Antigens, CD / Q000187:drug effects / Q000235:genetics; D015415:Biomarkers; D006801:Humans; D007168:IMP Dehydrogenase / Q000378:metabolism*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053645:Interleukin-2 Receptor alpha Subunit / Q000187:drug effects / Q000235:genetics; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D019520:Living Donors; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011990:Receptors, Transferrin / Q000187:drug effects / Q000235:genetics; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D015703:Antigens, CD; D015415:Biomarkers; C068126:CD71 antigen; D007166:Immunosuppressive Agents; D053645:Interleukin-2 Receptor alpha Subunit; D011990:Receptors, Transferrin; D007168:IMP Dehydrogenase; D009173:Mycophenolic Acid