[Effect of hydroxyethyl starch on vascular reactivity of rat during hemorrhagic shock].
OBJECTIVE
To study the effect of hydroxyethyl starch (HES) on vascular reactivity of rat during hemorrhagic shock and its mechanism.


METHODS
Forty SD rats were randomly divided into 5 groups: normal control group, shock group, sodium chloride (SC) group, HES 130/0.4 group and HES 200/0.5 group with 8 rats in each group. Rats were hemorrhaged and maintained mean arterial pressure (MAP) at 40 mm Hg (1 mm Hg=0.133 kPa) for 30 minutes, then rats were infused with fluids to restore and maintain MAP at 70 mm Hg for 60 minutes. The infusion volumes of each fluid to maintain MAP were recorded. The responses of MAP to norepinephrine (NE) were measured before shock, at 30, 60 and 90 minutes during hemorrhagic shock. Concentrations of nitric oxide (NO) and nitric oxide synthase (NOS) of plasma were measured at 90 minutes during hemorrhagic shock.


RESULTS
The infusion volumes of each fluid to maintain MAP were significantly different (all P<0.01). HES 200/0.5 group<HES 130/0.4 group<SC group. In HES 130/0.4 group and HES 200/0.5 group at 90 minutes during hemorrhagic shock, the responses of MAP to NE were improved significantly compared with those of SC group (both P<0.05), plasma contents of NO and NOS were reduced markedly compared with those of SC group (P<0.05 or P<0.01).


CONCLUSIONS
HES can improve vascular reactivity during hemorrhagic shock by inhibiting plasma contents of NO and NOS.
Zhao
Zhi-bin
ZB
Department of Anesthesiology, The First People's Hospital of Lianyungang, Lianyungang 222002, Jiangsu, China. zzb811@yahoo.com.cn
Chen
Ying
Y
Gao
Xin-yue
XY
Zeng
Yin-ming
YM
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000097:blood; D010952:Plasma Substitutes / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology
D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase