title: A gold(I) complex with a vitamin K3 derivative: characterization and antitumoral activity.
abstract: Reaction of the vitamin K(3) derivative menadione sodium bisulfite thiosemicarbazone (NaK(3)TSC) with chloro(triethylphosphine)gold(I) afforded the complex [AuPEt(3)(K(3)TSC)]. This compound consists of discrete molecules in which the metal is almost linearly coordinated to P and S. Preliminary in vitro screening showed significant anti-cancer activity, notably against the cisplatin-resistant cell line A2780cis.
authors.affiliation: Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain. qiscasas@usc.es <qiscasas@usc.es>
authors.forename: José S
authors.initials: JS
authors.lastname: Casas
authors.forename: Eduardo E
authors.initials: EE
authors.lastname: Castellano
authors.forename: María D
authors.initials: MD
authors.lastname: Couce
authors.forename: Javier
authors.initials: J
authors.lastname: Ellena
authors.forename: Agustín
authors.initials: A
authors.lastname: Sánchez
authors.forename: José
authors.initials: J
authors.lastname: Sordo
authors.forename: Carmen
authors.initials: C
authors.lastname: Taboada
mesh_terms: D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D050607:Organogold Compounds / Q000737:chemistry* / Q000494:pharmacology; D024483:Vitamin K 3 / Q000737:chemistry*
chemical_list: D050607:Organogold Compounds; C447642:chloro(triethylphosphine)gold(I); D024483:Vitamin K 3; D002945:Cisplatin