title: Scaling and root planing and chlorhexidine mouthrinses in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial.
abstract: OBJECTIVE
  Evaluation of the clinical and microbiological effects of scaling and root planing (SRP) alone or in combination with 0.12% chlorhexidine (CHX) rinsing.
  
  
  METHODS
  A blind, placebo-controlled, parallel-design, randomized clinical trial was conducted in 29 subjects with chronic periodontitis. Subjects were assigned to two therapeutic groups: control (SRP+placebo) and test (SRP+CHX during and up to 42 days post-therapy). Clinical and microbiological [N-benzoyl-dl-arginine-2-naphthylamide (BANA test)] examinations were performed at baseline, 42 and 63 days post-therapy.
  
  
  RESULTS
  Initially, intermediate sites (4-6 mm) in the test group showed less plaque accumulation, gingival bleeding, bleeding on probing and a greater reduction in attachment level and probing depth (PD) at 63 days after treatment. The initially deep sites (>6 mm) in the CHX group also showed a better reduction in plaque accumulation and in PD compared with the control group. Both therapies led to a microbiological improvement; however, the test subjects showed a higher frequency of BANA-negative sites after treatment, which was sustained over time (p<0.001). At 63 days, the control group presented 25 BANA-negative sites and 65 positive sites, and the test group 58 and 26, respectively.
  
  
  CONCLUSIONS
  The combination of CHX rinses and SRP leads to clinical benefits and to a better reduction in BANA-positive species.
authors.affiliation: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Faveri
authors.forename: Lauren Christine
authors.initials: LC
authors.lastname: Gursky
authors.forename: Magda
authors.initials: M
authors.lastname: Feres
authors.forename: Jamil Awad
authors.initials: JA
authors.lastname: Shibli
authors.forename: Sergio Luiz
authors.initials: SL
authors.lastname: Salvador
authors.forename: Luciene Cristina
authors.initials: LC
authors.lastname: de Figueiredo
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification; D001587:Benzoylarginine-2-Naphthylamide; D002710:Chlorhexidine / Q000627:therapeutic use*; D002908:Chronic Disease; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000382:microbiology / Q000628:therapy; D010514:Periodontal Pocket / Q000382:microbiology / Q000628:therapy; D010518:Periodontitis / Q000382:microbiology / Q000628:therapy*; D010919:Placebos; D016745:Root Planing; D016037:Single-Blind Method
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D010919:Placebos; D001587:Benzoylarginine-2-Naphthylamide; D002710:Chlorhexidine