Associations between exposure to polycyclic aromatic hydrocarbons and temporal change of urinary 1-hydroxypyrene levels in Taiwanese coke-oven workers.
OBJECTIVE
Our aim is to analyze the association between polycyclic aromatic hydrocarbon (PAH) exposure and the temporal change of urinary 1-hydroxypyrene (1-OHP).


METHODS
Two personal air samples, eight spot urine samples, and questionnaires were used to collect PAH exposure, urinary 1-OHP, demographic data, and environmental pollutants.


RESULTS
Topside-oven workers had significantly higher levels of PAH exposure and 1-OHP than side-oven workers. Urinary 1-OHP was a biomarker for PAH exposure. In topside-oven workers, the trend of 1-OHP increased sharply and reached the top in the sixth day after work and declined dramatically on days off. In side-oven workers, such a trend was not found, and those who smoked showed a slight increase in urinary 1-OHP levels on days off.


CONCLUSIONS
We suggest that the pattern of temporal change of urinary 1-OHP levels is different between topside-oven and side-oven workers.
Lin
Ying-Chu
YC
Graduate Institute of Dental Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Pan
Chih-Hong
CH
Chen
Chiou-Jong
CJ
Wu
Kuen-Yuh
KY
Chang-Chien
Guo-Ping
GP
Ho
Chi-Kung
CK
Wu
Trong-Neng
TN
Chuang
Hong-Yi
HY
Kuo
Hsien-Wen
HW
Wu
Ming-Tsang
MT
D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D003077:Coke; D006801:Humans; D016014:Linear Models; D008297:Male; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis*; D011721:Pyrenes / Q000378:metabolism*; D013624:Taiwan
D000395:Air Pollutants, Occupational; D003077:Coke; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C033146:1-hydroxypyrene