title: Lack of neutralizing antibody response to HIV-1 predisposes to superinfection.
abstract: Occurrences of HIV-1 superinfection offer a unique opportunity to investigate the correlates of immune protection. Here we describe the neutralizing antibody responses of a cohort of recently infected individuals who were screened for HIV superinfection. Three individuals identified with HIV superinfection had less cross-protective and autologous neutralizing antibody response than their non-superinfected case-controls. Neutralizing antibody may be crucial in the protection against superinfection and may explain why superinfection has only been documented following recent infection or treatment interruption. These data have considerable implications for vaccine development.
authors.affiliation: University of California San Diego, La Jolla, CA 92093-0679, USA. davey@ucsd.edu
authors.forename: Davey M
authors.initials: DM
authors.lastname: Smith
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Strain
authors.forename: Simon D W
authors.initials: SD
authors.lastname: Frost
authors.forename: Satish K
authors.initials: SK
authors.lastname: Pillai
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Wong
authors.forename: Terri
authors.initials: T
authors.lastname: Wrin
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Christos J
authors.initials: CJ
authors.lastname: Petropolous
authors.forename: Eric S
authors.initials: ES
authors.lastname: Daar
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Little
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Richman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009500:Neutralization Tests; D015163:Superinfection / Q000276:immunology* / Q000821:virology
chemical_list: D015483:HIV Antibodies