title: Elastic, superporous hydrogel hybrids of polyacrylamide and sodium alginate.
abstract: A novel approach was developed to prepare a superporous hydrogel with superior mechanical and elastic properties. According to this method, a synthetic monomer was polymerized and crosslinked in the presence of a water-soluble alginate polymer. Later in the process, the alginate part of the synthesized hydrogel was treated with metal cations, which resulted in a hydrogel hybrid with an interpenetrating network structure. In this article, a hydrogel hybrid of acrylamide and alginate is highlighted because of its unique swelling and mechanical properties. This hydrogel hybrid shows resilience and a rubbery property in its fully water-swollen state, which not previously been reported. To help understand the underlying mechanism responsible for such unique properties with hydrogel hybrids, the ionotropic gelation of the alginate polymer was also studied in more detail.
authors.affiliation: Kos Pharmaceuticals, Inc.; Hollywood, Florida 33020, USA. homidian@kospharm.com
authors.forename: Hossein
authors.initials: H
authors.lastname: Omidian
authors.forename: Jose G
authors.initials: JG
authors.lastname: Rocca
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000464:Alginates / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002122:Calcium Chloride / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004548:Elasticity; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis*; D008956:Models, Chemical; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis; D016062:Porosity; D033081:Shear Strength; D014867:Water / Q000378:metabolism; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000464:Alginates; D001672:Biocompatible Materials; D002122:Calcium Chloride; D003432:Cross-Linking Reagents; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D020100:Hydrogels; D011108:Polymers; D014867:Water; D000099166:Polyacrylamides