title: Unique expression of human papilloma virus type 5 and type 16 in esophageal squamous cell carcinoma-a case report.
abstract: The role of human papilloma virus (HPV) in esophageal cancers from the low-incidence area (Western population) is unclear. We report a case of esophageal squamous papillomatosis associated with underlying esophageal squamous cell carcinoma (OSCC). The esophagectomy specimen confirmed presence of HPV-5 and HPV-16 suggesting a viral etiology. The significance of this dual infection is not known, but it suggests that esophageal papillomatosis is premalignant and should receive regular endoscopic follow-up. This is the first report of both HPV-5 and HPV-16 DNA detected in an esophageal cancer occurring in the Western population.
authors.affiliation: Department of Gastroenterology, Royal Liverpool and Broadgreen University Hospitals, Liverpool, United Kingdom.
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Saravanan
authors.forename: Silva
authors.initials: S
authors.lastname: Youshya
authors.forename: Fiona
authors.initials: F
authors.lastname: Campbell
authors.forename: Handong
authors.initials: H
authors.lastname: Ran
authors.forename: Anthony I
authors.initials: AI
authors.lastname: Morris
authors.forename: Charlotte
authors.initials: C
authors.lastname: Proby
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D004279:DNA, Viral / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D027383:Papillomaviridae / Q000235:genetics*
chemical_list: D004279:DNA, Viral