title: Life is degrading--thanks to some zomes.
abstract: Three structurally related protein complexes, the COP9 signalosome, the proteasome lid, and the eukaryotic translation initiation factor 3, are revealing new insights into developmental processes and into cell cycle control in healthy cells and cells exposed to genotoxic stress. Newly discovered cullin-RING E3 ubiquitin ligases assembled on the CUL4 platform may provide links between DNA replication, chromatin, and proteolysis.
authors.affiliation: Department of Biochemistry, Cellular and Molecular Biology, The University of Tennessee, Knoxville, Tennessee 37996, USA. vonarnim@utk.edu
authors.forename: Albrecht G
authors.initials: AG
authors.lastname: von Arnim
authors.forename: Claus
authors.initials: C
authors.lastname: Schwechheimer
mesh_terms: D000818:Animals; D000075686:COP9 Signalosome Complex; D004249:DNA Damage; D039621:Eukaryotic Initiation Factor-3 / Q000378:metabolism; D046912:Multiprotein Complexes / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D039621:Eukaryotic Initiation Factor-3; D046912:Multiprotein Complexes; D044767:Ubiquitin-Protein Ligases; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D046988:Proteasome Endopeptidase Complex