The association of neuroleptic sensitivity in Lewy body disease with a false positive clinical diagnosis of Creutzfeldt-Jakob disease.
BACKGROUND
Dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) share clinical features like cognitive decline, motor disturbances en psychiatric symptoms. Overlapping symptoms may cause physicians to mistake DLB for CJD.


METHODS
Clinical data of 12 patients with autopsy-confirmed DLB who had been clinically suspected to suffer from CJD were analysed to investigate possible clinical features which led to misdiagnosis.


RESULTS
There was an association in time between administering neuroleptics and rapid clinical deterioration in 8 out of 9 patients.


CONCLUSIONS
It is suggested that the neuroleptic sensitivity in LBD fuelled the misdiagnosis of CJD in the presented series. Diagnostic confusion between CJD and DLB may have important clinical consequences and may lead to treatment restrictions.
Lemstra
A W
AW
Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands. a.w.lemstra@amc.uva.nl
Schoenmaker
N
N
Rozemuller-Kwakkel
A J M
AJ
van Gool
W A
WA
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D003951:Diagnostic Errors / Q000517:prevention & control*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012189:Retrospective Studies
D014150:Antipsychotic Agents