A case of 'hit-and-run' in Plasmodium genetics.
The ability to genetically manipulate species of the genus Plasmodium, some of which are causative organisms of malaria, has seen significant advances in the past 13 years. However, one major tool that has been lacking is the ability to undertake reverse genetics and 'hit-and-run' mutagenesis. This deficiency has been addressed in the Plasmodium berghei model.
Gardiner
Donald L
DL
Queensland Institute of Medical Research, Herston, 4006 Queensland, Australia.
Good
Michael F
MF
D000818:Animals; D030801:Animals, Genetically Modified; D018390:Gene Targeting; D005819:Genetic Markers; D005822:Genetic Vectors; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D009154:Mutation; D010962:Plasmodium berghei / Q000235:genetics* / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics; D011995:Recombination, Genetic; D013045:Species Specificity; D014170:Transformation, Genetic
D005819:Genetic Markers; D015800:Protozoan Proteins