title: [Palmoplantar hyperkeratosis associated with losartan].
abstract: Losartan belongs to the group of angiotensin II receptor antagonists and is used for the treatment of hypertension and heart failure. It acts in the renin angiotensin system (RAS) by blocking the angiotensin II receptor. There have been several reports on cutaneous side events by angiotensin antagonists due to their effect on the local cutaneous RAS. We review the case of palmoplantar lesions that developed in a patient taking losartan and the subsequent remission after treatment withdrawal. Since these reactions are being increasingly reported and as they can mimic a broad variety of classical skin disorders, they should be considered as the cause of sudden, inexplicable skin eruptions in patients taking angiotensin receptor antagonists.
authors.affiliation: Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, España. mcalvopulido@yahoo.es
authors.forename: M
authors.initials: M
authors.lastname: Calvo
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Guarino
authors.forename: E
authors.initials: E
authors.lastname: Martín-Saez
authors.forename: R
authors.initials: R
authors.lastname: Carrillo
authors.forename: M
authors.initials: M
authors.lastname: Garate
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000139:chemically induced*; D019808:Losartan / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D019808:Losartan