title: Genetic variability in the sapovirus capsid protein.
abstract: Sapovirus (SV), which causes gastroenteritis in humans, is composed of genetically divergent viruses classified into 5 genogroups. In this study, 2.2-kb nucleotide sequences of the 3' terminus of the genome of 15 SV strains detected in Japan were determined. The 15 SV strains could be classified into four genogroups (GI, GII, GIV and GV), and in two of these, GI and GII, 10 genotypes were identified. The amino acid sequences of the central variable region of the capsid protein showed less than 81% identity when strains belonging to different genotypes were compared. It was therefore supposed that antigenic variety exists between different genotypes. These results will be useful for further genetic and antigenic analyses of SV.
authors.affiliation: Division of Virology, Chiba Prefectural Institute of Public Health, Chiba-shi, Chiba 260-8715, Japan. m.okd4@mc.pref.chiba.jp
authors.forename: Mineyuki
authors.initials: M
authors.lastname: Okada
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Oseto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ogawa
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kaiho
authors.forename: Kuniko
authors.initials: K
authors.lastname: Shinozaki
mesh_terms: D000940:Antigenic Variation; D001483:Base Sequence; D036022:Capsid Proteins / Q000235:genetics*; D014644:Genetic Variation; D007564:Japan; D008969:Molecular Sequence Data; D010802:Phylogeny; D029341:Sapovirus / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D016415:Sequence Alignment
chemical_list: D036022:Capsid Proteins