Mechanisms of injury to the newborn brain.
Preterm and ill term infants are at risk for brain injury and subsequent neurodevelopmental delay as a result of many perinatal factors. Outlined in this article are the basic science mechanisms by which hypoxia, hypocapnia, and hypercapnia may result in neuronal injury in the newborn brain.
Fritz
Karen I
KI
Department of Pediatrics, Division of Neonatology, St. Christopher's Hospital for Children, Front and Erie Streets, Philadelphia, PA 19134, USA. Karen.Fritz@drexelmed.edu
Delivoria-Papadopoulos
Maria
M
D001927:Brain Diseases / Q000209:etiology* / Q000503:physiopathology; D020013:Calcium Signaling / Q000502:physiology; D053938:DNA Fragmentation / Q000502:physiology; D006801:Humans; D006935:Hypercapnia / Q000150:complications / Q000503:physiopathology; D016857:Hypocapnia / Q000150:complications / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000150:complications / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology* / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology
D018377:Neurotransmitter Agents