title: Aspergillus galactomannan enzyme-linked immunosorbent assay cross-reactivity caused by invasive Geotrichum capitatum.
abstract: We report three cases of invasive Geotrichum capitatum infection in patients with acute leukemia for which an enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence of aspergillosis. Supernatants obtained from suspensions of 17 G. capitatum strains gave positive reactions with the Aspergillus galactomannan ELISA. These clinical and laboratory data seem to suggest that G. capitatum produces a soluble antigen that is cross-reactive with Aspergillus galactomannan.
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza of Rome, Via Benevento 6, 00161 Rome, Italy.
authors.forename: Mareva
authors.initials: M
authors.lastname: Giacchino
authors.forename: Nadia
authors.initials: N
authors.lastname: Chiapello
authors.forename: Stefania
authors.initials: S
authors.lastname: Bezzio
authors.forename: Franca
authors.initials: F
authors.lastname: Fagioli
authors.forename: Paola
authors.initials: P
authors.lastname: Saracco
authors.forename: Alda
authors.initials: A
authors.lastname: Alfarano
authors.forename: Vincenza
authors.initials: V
authors.lastname: Martini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cimino
authors.forename: Pietro
authors.initials: P
authors.lastname: Martino
authors.forename: Corrado
authors.initials: C
authors.lastname: Girmenia
mesh_terms: D000946:Antigens, Fungal / Q000276:immunology*; D001230:Aspergillus / Q000276:immunology*; D002648:Child; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D005847:Geotrichosis / Q000276:immunology / Q000382:microbiology; D005848:Geotrichum / Q000276:immunology*; D006801:Humans; D008297:Male; D008351:Mannans / Q000276:immunology*; D008875:Middle Aged
chemical_list: D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose