title: Liver adenomatosis: classification of MR imaging features and comparison with pathologic findings.
abstract: OBJECTIVE
  To retrospectively compare the clinical manifestation and magnetic resonance (MR) imaging features of liver adenomatosis with pathologic findings.
  
  
  METHODS
  This study had institutional review board approval, and informed consent was waived. Twenty patients were classified on the basis of pathologic findings into three groups: those with a steatotic, those with a peliotic, and those with a mixed (steatotic and peliotic) form of liver adenomatosis. MR images were reviewed in consensus by two abdominal radiologists, and findings were compared with the pathologic classification. Statistical evaluation was performed with the Student t test.
  
  
  RESULTS
  All patients were women (mean age, 39 years +/- 10 [standard deviation]). Lesions of the steatotic form (n = 7) showed (a) a mean diameter of 6.3 cm +/- 1.7, (b) slightly hyperintense signal on T2-weighted images, (c) hyper- or isointense signal on T1-weighted images with a signal dropout with fat suppression sequences, and (d) moderate enhancement at the arterial phase with no delayed enhancement. Lesions of the peliotic form (n = 7) showed (a) a somewhat larger size (8.3 cm +/- 3.6), (b) markedly hyperintense signal on T2-weighted images, (c) iso- or hyperintensity on T1-weighted images with no signal dropout with fat suppression sequences, and (d) strong arterial enhancement and persistent enhancement at the portal and delayed phase. Lesions of the mixed form (n = 6) included a combination of imaging features of the steatotic and peliotic forms. Lesions, however, were significantly larger in the mixed form than in the steatotic form (10.3 cm +/- 4, P < .05).
  
  
  CONCLUSIONS
  There are three patterns of MR imaging features of liver adenomatosis that are associated with three pathologic forms (steatotic, peliotic, and mixed).
authors.affiliation: Department of Radiology, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France. maite.lewin@sat.ap-hop-paris.fr
authors.forename: Maïté
authors.initials: M
authors.lastname: Lewin
authors.forename: Adriana
authors.initials: A
authors.lastname: Handra-Luca
authors.forename: Lionel
authors.initials: L
authors.lastname: Arrivé
authors.forename: Dominique
authors.initials: D
authors.lastname: Wendum
authors.forename: Valérie
authors.initials: V
authors.lastname: Paradis
authors.forename: Etienne
authors.initials: E
authors.lastname: Bridel
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Fléjou
authors.forename: Jacques
authors.initials: J
authors.lastname: Belghiti
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Tubiana
authors.forename: Valérie
authors.initials: V
authors.lastname: Vilgrain
mesh_terms: D018248:Adenoma, Liver Cell / Q000473:pathology*; D000328:Adult; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine