title: A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13.
abstract: The authors investigated genetic factors contributing to restless legs syndrome (RLS) by performing a 10-cM genome-wide scan in a large French-Canadian pedigree. They detected an autosomal-dominant locus mapping to chromosome 20p13, with a maximum multipoint lod score of 3.86 at marker D20S849. This is the third reported autosomal-dominant locus for RLS and the first autosomal-dominant RLS locus in the French-Canadian population.
authors.affiliation: Center for the Study of Brain Diseases, CHUM Research Center-Notre Dame Hospital, Montreal, Quebec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Levchenko
authors.forename: S
authors.initials: S
authors.lastname: Provost
authors.forename: J Y
authors.initials: JY
authors.lastname: Montplaisir
authors.forename: L
authors.initials: L
authors.lastname: Xiong
authors.forename: J
authors.initials: J
authors.lastname: St-Onge
authors.forename: P
authors.initials: P
authors.lastname: Thibodeau
authors.forename: J B
authors.initials: JB
authors.lastname: Rivière
authors.forename: A
authors.initials: A
authors.lastname: Desautels
authors.forename: G
authors.initials: G
authors.lastname: Turecki
authors.forename: M P
authors.initials: MP
authors.lastname: Dubé
authors.forename: G A
authors.initials: GA
authors.lastname: Rouleau
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D002890:Chromosomes, Human, Pair 20; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D012148:Restless Legs Syndrome / Q000235:genetics*