Treatment of pulmonary hypertension with sildenafil in a neonate with spondyloepiphyseal dysplasia congenita.
Persistent pulmonary hypertension of the newborn (PPHN) remains an important cause of mortality and morbidity in the term neonate. Preliminary but limited data suggest that there may be a role for sildenafil in the treatment of PPHN. We report the successful treatment of PPHN caused by pulmonary hypoplasia in a patient with spondyloepiphyseal dysplasia congenita.
Kecskes
Zsuzsoka
Z
Department of Neonatology, The Canberra Hospital, Garran, Australia. zsuzsoka.kecskes@act.gov.au
Kent
Alison
A
Reynolds
Graham
G
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010009:Osteochondrodysplasias / Q000150:complications / Q000151:congenital; D010547:Persistent Fetal Circulation Syndrome / Q000188:drug therapy* / Q000209:etiology; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000627:therapeutic use*
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate