title: Atherosclerosis: immune and inflammatory aspects.
abstract: This review article discusses the historical origin of our continuously evolving model of the etiology of atherosclerotic cardiovascular disease. The basic molecular biologic concepts underlying the development of coronary artery disease and the dynamic connection between the immune system and arterial integrity are explored. Emphasis is placed on the role of inflammation as a driving force in the process of atherosclerosis and vascular endothelium as a modulating factor in the pathogenesis of coronary artery disease.
authors.affiliation: Vascular Biology Institute, Winthrop University Hospital, 222 Station Plaza, North, Suite 511-A, Mineola, NY 11501, USA. AReiss@Winthrop.org
authors.forename: Allison B
authors.initials: AB
authors.lastname: Reiss
authors.forename: Amy D
authors.initials: AD
authors.lastname: Glass
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000502:physiology; D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology*; D001692:Biological Transport; D053493:Cholestanetriol 26-Monooxygenase; D002784:Cholesterol / Q000378:metabolism; D003327:Coronary Disease / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007371:Interferon-gamma / Q000502:physiology; D008099:Liver / Q000378:metabolism; D013250:Steroid Hydroxylases / Q000502:physiology; D051193:Toll-Like Receptors / Q000502:physiology
chemical_list: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D051193:Toll-Like Receptors; D007371:Interferon-gamma; D002784:Cholesterol; D013250:Steroid Hydroxylases; C506831:CYP27A1 protein, human; D053493:Cholestanetriol 26-Monooxygenase