[Adverse reaction after use of latanoprost in Japanese glaucoma patients].
OBJECTIVE
Although latanoprost has proven to have a strong hypotensive effect, some patients show adverse reactions such as eyelid pigmentation, iridial pigmentation, or hypertrichosis. We prospectively investigated these adverse reactions.


METHODS
One hundred and one Japanese glaucoma or ocular hypertension patients were included. Iridial, eyelid, and eyelash photographs were taken before and at 6 months after latanoprost treatment. Increased eyelid pigmentation, iridial pigmentation, eyelash pigmentation, vellus hair of the lid, and hypertrichosis were assessed from these photographs. The correlation between the incidence of these adverse reactions and the time of instillation, type of glaucoma, sex, age, or concomitantly used eye drops, and the overlap of these were evaluated.


RESULTS
Increased pigmentation of the eyelid was found in 6 cases(5.9%), of the iris in 32 cases (31.7%), of the eyelashes in 29 cases (28.7%), vellus hair of the lid in 38 cases(37.6%), and hypertrichosis in 51 cases(50.5%). Pigmentation of the eyelid was more frequently observed in patients who used latanoprost concomitantly (16.7%) than in those who did not use anti-glaucomatous eye drops before latanoprost treatment (1.6%), or in those treated with latanoprost who had switched from other anti-glaucomatous eye drops (6.3%) (p= 0.03).


CONCLUSIONS
The incidence of adverse reactions caused by latanoprost was higher in the eyelashes and iris than in the eyelid.
Inoue
Kenji
K
Inouye Eye Hospital, Tokyo, Japan. inoue-k@fd5.so-net.ne.jp
Wakakura
Masato
M
Inoue
Jiro
J
Matsuo
Hiroshi
H
Hara
Takeshi
T
Tomita
Goji
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005140:Eyelashes / Q000187:drug effects; D005143:Eyelids; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007498:Iris / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000139:chemically induced*; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*
D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost