No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.
Most genetic association studies in bipolar disorder have focussed on genes involved in major neurotransmitter systems or brain development. Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val158Met) and dopamine D3 receptor (Ser9Gly) genes have all been associated with bipolar disorder. We aimed at investigating whether these functional variants contribute to the genetic etiology of bipolar disorder in a northern Swedish isolated population. Moreover, we wanted to gain information about the synergistic contribution of these functional variants. Neither of these functional polymorphisms was associated with bipolar disorder in the northern Swedish patient-control sample nor did we find evidence of gene-gene interaction. Together, our data suggest that these functional variants are not involved in the etiology of bipolar disorder in the northern Swedish population nor did gene-gene interaction analysis support a central role of these variants in bipolar disorder.
Van Den Bogaert
Ann
A
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerp, Belgium.
Sleegers
Kristel
K
De Zutter
Sonia
S
Heyrman
Lien
L
Norrback
Karl-Fredrik
KF
Adolfsson
Rolf
R
Van Broeckhoven
Christine
C
Del-Favero
Jurgen
J
D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D050637:Receptors, Dopamine D3 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D013548:Sweden
D050637:Receptors, Dopamine D3; D050486:Serotonin Plasma Membrane Transport Proteins; D002394:Catechol O-Methyltransferase