title: Systemic and local CC chemokines production in a murine model of Listeria monocytogenes infection.
abstract: Repeated intragastric inoculation of Listeria monocytogenes into BALB/c mice resulted in prolonged bacteraemia and severe hepatic infection. Bacteria could also be isolated from the brain tissue of all experimental mice. During the inflammatory process, chemokine concentrations typically increased at the local site in comparison to the systemic level. The liver-to-serum ratio was more pronounced in the case of macrophage inflammatory protein 1 alpha (MIP-1 alpha), suggesting its role in the inflammatory response in the liver. The ratio of brain-to-serum concentration of monocyte chemoattractant protein 1 (MCP-1) remained the same as in the control animals, while it was lower in the infected mice, both in the case MIP-1alpha and in the case of regulated on activation, normal T cell expressed and secreted (RANTES). This is in correlation with slight inflammatory infiltrates found in the brain tissue early in infection.
authors.affiliation: Department of Microbiology, Medical Faculty, University of Rijeka, 51000 Rijeka, Croatia.
authors.forename: Marina
authors.initials: M
authors.lastname: Bubonja
authors.forename: Branka
authors.initials: B
authors.lastname: Wraber
authors.forename: Gordana
authors.initials: G
authors.lastname: Brumini
authors.forename: Ivana
authors.initials: I
authors.lastname: Gobin
authors.forename: Danijela
authors.initials: D
authors.lastname: Veljkovic
authors.forename: Maja
authors.initials: M
authors.lastname: Abram
mesh_terms: D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D018932:Chemokine CCL2 / Q000096:biosynthesis; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000096:biosynthesis; D019742:Chemokines, CC / Q000096:biosynthesis*; D008088:Listeriosis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D019402:Macrophage Inflammatory Proteins / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D018932:Chemokine CCL2; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins