Endothelial signalling events during leukocyte transmigration.
The notion that it takes two to tango is certainly true for leukocyte transendothelial migration. A growing pallet of leukocyte adhesion-induced signaling events in endothelial cells have been identified, mediating both short-term (i.e. permeability) as well as long-term (i.e. regulation of transcription) effects. Efficient paracellular migration (i.e. through endothelial cell-cell junctions) requires both intracellular calcium and the actin cytoskeleton, but also involves small GTPases, reactive oxygen species and protein kinases. The alternative route of transcellular migration appears to depend on components such as caveolae and intermediate filaments. This minireview discusses our current knowledge on the regulation of leukocyte transmigration through endothelial signalling.
Hordijk
Peter L
PL
Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, the Netherlands. p.hordijk@sanquin.nl
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D019040:E-Selectin / Q000502:physiology; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000502:physiology; D033081:Shear Strength; D015398:Signal Transduction; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology
D019040:E-Selectin; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019010:Vascular Cell Adhesion Molecule-1