title: [Massive breast angiomatosis with dramatic course leading to acute total mastectomy--a case report].
abstract: OBJECTIVE
  On the background of clinical, radiological and morphologic settings presented is unusual case of the rare angiomatosis of the female breast. Discussed are both clinicopathological aspects and differential diagnosis from the morphological point of view.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Biopsy Lab s.r.o. and Sikl's Department of Pathology, Charles University and Faculty Hospital, Pilsen.
  
  
  METHODS
  As a case report described is a rare case of the angiomatosis of the female breast. Implemented illustrations consist of local findings, CT scan, specimen gross appearance and histological pictures including immunohistochemistry. Applied antibodies and detection system LSAB+ were provided by Dako, visualization was performed by chromogen DAB (diaminobenzidin tetrahydrochlorid).
  
  
  RESULTS
  30-year-old woman suffering of painful, enormous breast asymmetry underwent core needle biopsy of the right breast. The mastogram showed diffuse process of ambiguous significance. During the next few days her condition dramatically changed and under the circumstances of florid apoplexy and suspicion of tumor of her right breast, total mastectomy was carried out. Histological picture revealed widespread, unlimited vascular lesion dissecting throughout the stroma of the entire gland. Bland morphology and the nature of tissue involvement eventually led to diagnosis of benign angiomatosis. The woman underwent several local plastic operations but is out of final reconstruction of her breast so far. Thirteen months after mastectomy there are no signs of recurrence.
authors.affiliation: Biopsy Lab s.r.o. and Sikl's Department of Pathology, Charles University and Faculty Hospital, Pilsen.
authors.forename: Z
authors.initials: Z
authors.lastname: Kinkor
authors.forename: O
authors.initials: O
authors.lastname: Hes
authors.forename: A
authors.initials: A
authors.lastname: Skálová
authors.forename: B
authors.initials: B
authors.lastname: Kreuzberg
authors.forename: I
authors.initials: I
authors.lastname: Neprasová
mesh_terms: D000328:Adult; D000798:Angiomatosis / Q000473:pathology / Q000601:surgery*; D001941:Breast Diseases / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008408:Mastectomy