Quantitative analysis of chondroitin sulfate in tear fluids following laser in situ keratomileusis.
OBJECTIVE
To report chondroitin sulfate (CS) concentrations in tear fluid following laser in situ keratomileusis (LASIK).


METHODS
Fourteen eyes that underwent LASIK were enrolled. We measured the CS isomers chondroitin 4 sulfate and chondroitin 6 sulfate using an enzyme-linked immunosorbent assay preoperatively and postoperatively on days 1 and 4, week 1, and 1 and 3 months.


RESULTS
The chondroitin 4 sulfate concentration remained unchanged from preoperative values. The chondroitin 6 sulfate concentration increased temporarily 1 day postoperatively and gradually decreased thereafter.


CONCLUSIONS
CS in tear fluids participates in wound healing after LASIK. Clarifying its role in tear fluids will contribute to improved LASIK outcomes.
Nishio
Masaya
M
Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan.
Arai
Kiyomi
K
D000328:Adult; D001251:Astigmatism / Q000601:surgery; D002809:Chondroitin Sulfates / Q000378:metabolism*; D003315:Cornea / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008297:Male; D009216:Myopia / Q000601:surgery; D013666:Tears / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
D002809:Chondroitin Sulfates