Serotonin transporter genotype and acute subjective response to amphetamine.
The authors have previously shown an effect of dopamine transporter genotype on acute subjective responses to d-amphetamine, which may affect risk of addiction. They now report the results of an evaluation of the role of the serotonin transporter gene (HTT) using a double-blind, placebo-controlled, crossover design in which subjects (N = 101) completed self-report measures of subjective effect. The separate and combined analyses of the gene-linked polymorphic region (5-HTTLPR) and the Intron 2 VNTR suggest that these two HTT polymorphisms may contribute to acute subjective responses to d-amphetamine with a small effect.
Lott
David C
DC
Linden Oaks Hospital at Edward, Naperville, Illinois, USA. dlott@jhu.edu
Kim
Soo-Jeong
SJ
Cook
Edwin H
EH
de Wit
Harriet
H
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects*; D000483:Alleles; D019969:Amphetamine-Related Disorders / Q000235:genetics* / Q000523:psychology; D001143:Arousal / Q000187:drug effects / Q000235:genetics; D018592:Cross-Over Studies; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics*; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D019966:Substance-Related Disorders / Q000235:genetics / Q000523:psychology
D050486:Serotonin Plasma Membrane Transport Proteins; D003913:Dextroamphetamine