Walking through protein sequence space.
Following the original idea of Maynard Smith on evolution of the protein sequence space, a novel tool is developed that allows the "space walk", from one sequence to its likely evolutionary relative and further on. At a given threshold of identity between consecutive steps, the walks of many steps are possible. The sequences at the ends of the walks may substantially differ from one another. In a sequence space of randomized (shuffled) sequences the walks are very short. The approach opens new perspectives for protein evolutionary studies and sequence annotation.
Frenkel
Zakharia M
ZM
Genome Diversity Center, Institute of Evolution, University of Haifa, Haifa 31905, Israel. zakharf@research.haifa.ac.il <zakharf@research.haifa.ac.il>
Trifonov
Edward N
EN
D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000595:Amino Acid Sequence; D019143:Evolution, Molecular; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D020539:Sequence Analysis, Protein / Q000379:methods*
D018528:ATP-Binding Cassette Transporters; D011506:Proteins