[Analysis of the mode of inheritance in familial bronchial asthma].
To study the mode of inheritance of familial bronchial asthma and to understand the population genetics laws of bronchial asthma, Families with a family history of bronchial asthma in Handan region were investigated using group research method. The xi2 test of the degree of coincidence between the expected and observed values was analyzed by pedigree analysis and the "Smith" agonic revise method. The incidence rate within the 72 families pedigree with familial bronchial asthma, including 109 core pedigrees, is 0.46. Analysis shows a tendency towards single gene inheritance. Pedigree analysis reveals that it is consistent with autosome dominant inheritance. Analysis of the D- x dd marriage with the "Smith" analytical method supports this conclusion (xi2 = 3.181, P > 0.05) and further hints there exists genetic heterogeneity, i.e. different modes of inheritance among different marriage types. Our results can offer the reference to the prevention, diagnosis and treatment of familial bronchial asthma.
Ren
Xin-Luan
XL
Medical College of Hebei Engineering University, Handan, China. renxinluan@163.com
Li
Lian-Xiang
LX
Han
Shu-Ping
SP
Cai
Jie
J
Zhang
Hong-Yi
HY
Ma
Chang-Yi
CY
D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control / Q000628:therapy; D016022:Case-Control Studies; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D015994:Incidence; D040582:Inheritance Patterns; D008297:Male; D008393:Marriage; D008875:Middle Aged; D010375:Pedigree