title: Selective serotonin reuptake inhibitors and rhabdomyolysis after eccentric exercise.
abstract: OBJECTIVE
  The purpose of this report was to review three cases of clinically significant rhabdomyolysis that developed in research subjects after completing an eccentric exercise protocol. All three cases occurred in subjects who reported use of selective serotonin reuptake inhibitors (SSRI).
  
  
  METHODS
  Sixty-three subjects enrolled in the study. Subjects performed 15 sets of 15 repetitions of maximal eccentric contractions of the elbow flexors. Subjects were then monitored on a daily basis for development of delayed onset muscle soreness (DOMS). Subjects received either microcurrent electrical neuromuscular stimulation (MENS) or sham treatment.
  
  
  RESULTS
  Three subjects developed clinically significant rhabdomyolysis after performing this exercise protocol. Affected subjects were the only subjects who reported use of SSRI during the study period.
  
  
  CONCLUSIONS
  This report raises suspicion of SSRI use as a predisposing factor to muscle injury after eccentric exercise.
authors.affiliation: Division of Sports Medicine, Department of Family Medicine and Community Health, John A. Burns School of Medicine, Honolulu, HI 96813-5534, USA. labotz@hawaii.edu
authors.forename: Michele
authors.initials: M
authors.lastname: Labotz
authors.forename: Toby K
authors.initials: TK
authors.lastname: Wolff
authors.forename: Kenneth T
authors.initials: KT
authors.lastname: Nakasone
authors.forename: Iris F
authors.initials: IF
authors.lastname: Kimura
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Hetzler
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Nichols
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D005082:Physical Exertion / Q000502:physiology*; D012206:Rhabdomyolysis / Q000097:blood / Q000209:etiology* / Q000628:therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D012720:Severity of Illness Index; D004561:Transcutaneous Electric Nerve Stimulation / Q000379:methods; D014891:Weight Lifting / Q000502:physiology*; D000092464:Elbow Injuries
chemical_list: D003402:Creatine Kinase; D017367:Selective Serotonin Reuptake Inhibitors