title: Studies on the toxicological detection of the designer drug 4-bromo-2,5-dimethoxy-beta-phenethylamine (2C-B) in rat urine using gas chromatography-mass spectrometry.
abstract: The phenethylamine-derived designer drug 4-bromo-2,5-dimethoxy-beta-phenethylamine (2C-B) is known to be extensively metabolized in various species including humans. In rat urine, 2C-B was found to be excreted mainly via its metabolites. In the current study, the toxicological detection of these metabolites in the authors' systematic toxicological analysis (STA) procedure was examined. The STA procedure using full-scan GC-MS allowed proving an intake of a common drug abusers' dose of 2C-B by detection of the O-demethyl deaminohydroxy and two isomers of the O-demethyl metabolites in rat urine. Assuming similar metabolism, the described STA procedure should be suitable for proof of an intake of 2C-B in human urine.
authors.affiliation: Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, D-66421 Homburg (Saar), Germany.
authors.forename: Denis S
authors.initials: DS
authors.lastname: Theobald
authors.forename: Giselher
authors.initials: G
authors.lastname: Fritschi
authors.forename: Hans H
authors.initials: HH
authors.lastname: Maurer
mesh_terms: D000818:Animals; D015198:Designer Drugs / Q000032:analysis* / Q000633:toxicity; D004118:Dimethoxyphenylethylamine / Q000031:analogs & derivatives* / Q000633:toxicity / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015198:Designer Drugs; D004118:Dimethoxyphenylethylamine; C079321:2-(4-bromo-2,5-dimethoxyphenyl)ethylamine