title: Conjunctival Splendore-Hoeppli phenomenon in a 3-year-old child.
abstract: A case of benign granulomas of the conjunctiva in a 3-year-old girl is reported. Histologic features of the excised conjunctival lesions were consistent with Splendore-Hoeppli phenomenon. This phenomenon is thought to be a granulomatous reaction to an antigen-antibody precipitate related to parasites or fungi. No causative agent is identified in our patient. Immunohistochemical analysis showed no immunoreactivity for immunoglobulin G (IgG), IgM, IgA, or the C3 component of the complement. We propose that the presence of small amelanotic nodular conjunctival tumors should arouse suspicion related to the Splendore-Hoeppli phenomenon even in early childhood.
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Ophthalmology, and Ihsan Doğramaci Children's Hospital, Ankara, Turkey. diclehan@hacettepe.edu.tr
authors.forename: Diclehan
authors.initials: D
authors.lastname: Orhan
authors.forename: Hayyam
authors.initials: H
authors.lastname: Kiratli
authors.forename: Sibel
authors.initials: S
authors.lastname: Kocabeyoğlu
mesh_terms: D002675:Child, Preschool; D003176:Complement C3 / Q000378:metabolism; D003229:Conjunctival Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry
chemical_list: D003176:Complement C3; D007136:Immunoglobulins