Preparation of N-succinyl-chitosan and its physical-chemical properties as a novel excipient.
The aim of this work is to prepare N-succinyl-chitosan (Suc-Chi) and measure physical-chemical properties for Suc-Chi as excipients. Suc-Chi were prepared via ring-opening reactions with succinic anhydride in Dimethyl Sulfoxide system. The physical-chemical properties of Suc-Chi, such as the degree of substitution (DS), solubility, isoelectric point (pI), glass transition temperature (Tg), partition coefficient (P(app)) and zata potential were detected respectively in order to evaluate their possibility as drug carriers. We obtained Suc-Chi DAC-90 (DS=0.33) and the data of physical-chemical properties for the product. The knowledges of physical-chemical properties for Suc-Chi are valuable for basic or applied purposes in biomedical and pharmaceutical sciences stabilization.
Yan
Chengyun
C
School of Pharmacy, Shenyang Pharmaceutical University, P.R. China.
Chen
Dawei
D
Gu
Jiwei
J
Hu
Haiyang
H
Zhao
Xiuli
X
Qiao
Mingxi
M
D055598:Chemical Phenomena; D002625:Chemistry, Organic; D002627:Chemistry, Physical; D048271:Chitosan / Q000138:chemical synthesis*; D004121:Dimethyl Sulfoxide; D004337:Drug Carriers; D055601:Organic Chemistry Phenomena; D013387:Succinic Anhydrides
D004337:Drug Carriers; C118639:N-succinyl-chitosan; D013387:Succinic Anhydrides; C031801:succinic anhydride; D048271:Chitosan; D004121:Dimethyl Sulfoxide