Childhood mesial temporal sclerosis.
The prevalence and clinical characteristics of mesial temporal sclerosis have not been well studied in children. All brain magnetic resonance imaging (MRI) reports of children less than 14 years of age were reviewed from two tertiary institutions. A 52-month period from one institution and a 37-month period from the other were reviewed. All reports of definite or possible mesial temporal sclerosis were noted. These patients' MRIs were then reviewed to confirm the MRI diagnostic criteria of mesial temporal sclerosis. The charts of the patients who satisfied these criteria were reviewed in detail. Three thousand one hundred brain MRI reports were reviewed. Twenty-six reports of mesial temporal sclerosis were found. Twenty-four of the 26 films satisfied the criteria of mesial temporal sclerosis by MRI after the films were reviewed. The prevalence among all pediatric brain MRI studies was 0.77%. All patients had presented with seizures, that is, there were no "incidental" findings of mesial temporal sclerosis. Four patients had a history of febrile seizures. Mesial temporal sclerosis is an uncommon finding in children, but when it occurs, it is always associated with epilepsy. Asymptomatic mesial temporal sclerosis or mesial temporal sclerosis not associated with a seizure disorder did not occur in our series. Febrile seizures can occur in association with mesial temporal sclerosis presenting in childhood.
Ng
Yu-tze
YT
Division of Child Neurology, St. Joseph's Hospital and Children's Health Center at Barrow Neurological Institute, 500 West Thomas Road, Phoenix, AZ 85013, USA. y2ng@chw.edu
McGregor
Amy L
AL
Duane
Dawn C
DC
Jahnke
Heidi K
HK
Bird
C Roger
CR
Wheless
James W
JW
D001927:Brain Diseases / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012598:Sclerosis; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology