title: A prospective study to assess the efficacy and patient tolerance of three bowel preparations for colonoscopy.
abstract: The adherence to the required clear liquid diet and a high-volume bowel cleansing solution prior to colonoscopy often leads to poor patient compliance and inadequate exams. This study evaluated the efficacy and patient tolerance of three bowel preparation regimens prior to colonoscopy. One hundred fourteen patients were randomized to one of three preparations. Group 1 was assigned a clear liquid diet/magnesium citrate and bisacodyl prep; group 2 was assigned to receive a diet kit/magnesium citrate and bisacodyl prep; and group 3 received a diet kit/polyethylene glycol electrolyte prep. The adequacy of bowel preparation was graded by the endoscopists performing the procedures. The preparations were rated by patients for tolerance, compliance, and side effects. The three methods of preparation did not prove to be significantly different in regards to efficacy of colon cleansing or patient tolerability. There was also no difference in compliance between the three regimens. There were no reported side effects in any of the study groups. This study suggests that a low-residue diet kit, given in conjunction with polyethylene glycol electrolyte or magnesium citrate and bisacodyl, produces adequate colon cleansing and patient tolerability.
authors.affiliation: Southern California Kaiser Permanente Medical Center, Division of Gastroenterology, San Diego, California, USA.
authors.forename: Roderick
authors.initials: R
authors.lastname: Rapier
authors.forename: Carmela
authors.initials: C
authors.lastname: Houston
mesh_terms: D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001726:Bisacodyl / Q000009:adverse effects / Q000627:therapeutic use; D002400:Cathartics / Q000009:adverse effects / Q000627:therapeutic use*; D019343:Citric Acid / Q000009:adverse effects / Q000627:therapeutic use; D003113:Colonoscopy; D003131:Combined Modality Therapy; D005260:Female; D005526:Food, Formulated / Q000009:adverse effects; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009942:Organometallic Compounds / Q000009:adverse effects / Q000627:therapeutic use; D010349:Patient Compliance / Q000523:psychology* / Q000706:statistics & numerical data; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000627:therapeutic use; D011300:Preoperative Care / Q000379:methods* / Q000523:psychology; D011446:Prospective Studies; D016037:Single-Blind Method; D013488:Suppositories; D016896:Treatment Outcome
chemical_list: D002400:Cathartics; D009942:Organometallic Compounds; D013488:Suppositories; D001726:Bisacodyl; D019343:Citric Acid; D011092:Polyethylene Glycols; C110422:magnesium citrate