title: NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach.
abstract: The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population.
authors.affiliation: Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom. d.healy@ion.ucl.ac.uk
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Healy
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Abou-Sleiman
authors.forename: Kourosh R
authors.initials: KR
authors.lastname: Ahmadi
authors.forename: Sonia
authors.initials: S
authors.lastname: Gandhi
authors.forename: Miratul M
authors.initials: MM
authors.lastname: Muqit
authors.forename: Kailash P
authors.initials: KP
authors.lastname: Bhatia
authors.forename: Niall P
authors.initials: NP
authors.lastname: Quinn
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
authors.forename: Janice L
authors.initials: JL
authors.lastname: Holton
authors.forename: Tamas
authors.initials: T
authors.lastname: Revesz
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Wood
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D010300:Parkinson Disease / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C539882:NR4A2 protein, human; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D014157:Transcription Factors