Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion, and toxicity of aflatoxin B(1) in rats.
In this study, the modulation of aflatoxin B(1) (AFB(1)) uptake in rats by administration of the probiotic Lactobacillus rhamnosus GG was demonstrated. Fecal AFB(1) excretion in GG-treated rats was increased via bacterial AFB(1) binding. Furthermore, AFB(1)-associated growth faltering and liver injury were alleviated with GG treatment.
Gratz
S
S
Department of Clinical Nutrition, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland. silvia.gratz@uku.fi
Täubel
M
M
Juvonen
R O
RO
Viluksela
M
M
Turner
P C
PC
Mykkänen
H
H
El-Nezami
H
H
D016604:Aflatoxin B1 / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D005243:Feces / Q000737:chemistry; D007408:Intestinal Absorption / Q000502:physiology*; D052201:Lacticaseibacillus rhamnosus; D019936:Probiotics / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain
D016604:Aflatoxin B1