title: [Th1 and Th2 lymphocytes in perennial allergic rhinitis].
abstract: BACKGROUND
  The study of perennial allergic rhinitis is a good model to evidence the unbalance between Th1 and Th2 lymphocytes. This functional unbalance is manifested by the exaggerated production of pro-inflammatory cytokines and a reduction of the antiinflammatory ones.
  
  
  OBJECTIVE
  To corroborate these alterations in patients with perennial allergic rhinitis. PATIENTS AMD METHOD: In nine patients with perennial allergic rhinitis who had no immunotherapy treatment we measured the IFNgamma, IL-4, IL-10 and IL-13 levels through a flow citometry.
  
  
  RESULTS
  We found high levels of IL-10 (42%) and reduced IFNgamma values. We did not find IL-4 or IL-13 expressions in the studied patients.
  
  
  CONCLUSIONS
  These results make us to consider a Th1/Th2 unbalance towards a Th2 hyperfunction.
authors.affiliation: Servicio de alergia e inmunologia clinica, Hospital Juárez de México.
authors.forename: Daniel
authors.initials: D
authors.lastname: Aguilar Angeles
authors.forename: Ernestina
authors.initials: E
authors.lastname: Serrano Miranda
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Rojo Gutiérrez
authors.forename: Mario A
authors.initials: MA
authors.lastname: Bermejo Guevara
authors.forename: Sergio
authors.initials: S
authors.lastname: Estrada Parra
mesh_terms: D000328:Adult; D006801:Humans; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*