title: Zinc supplementation does not affect growth, morbidity, or motor development of US term breastfed infants at 4-10 mo of age.
abstract: BACKGROUND
  It has been documented that growth patterns differ between breastfed and formula-fed infants. Some investigators have suggested that these differences may be related to differences in zinc nutriture.
  
  
  OBJECTIVE
  The objective of this study was to examine the effect of zinc supplementation on growth, morbidity, and motor development in healthy, term, breastfed infants.
  
  
  METHODS
  We conducted a randomized double-blind intervention comparing zinc supplementation (5 mg/d as zinc sulfate) with placebo in breastfed infants aged 4-10 mo. Growth and indexes of body composition and gross motor development were measured monthly from 3 to 10 mo. Morbidity data were collected weekly.
  
  
  RESULTS
  Eighty-five infants were enrolled, and 70 completed the study. The baseline characteristics, attained weight or length at 10 mo, growth velocity, gross motor development, and morbidity did not differ significantly between groups, even after control for potentially confounding variables.
  
  
  CONCLUSIONS
  The dietary zinc intake of these breastfed infants appeared to be adequate, given that zinc supplementation did not affect growth, development, or risk of infection (although sample size for detection of differences in development or infection was limited). Previously described differences in growth between breastfed and formula-fed infants in such populations do not appear to be due to differences in zinc nutriture.
authors.affiliation: Department of Nutrition, University of California, Davis, Davis, CA 95616-8669, USA. mjheinig@ucdavis.edu
authors.forename: M Jane
authors.initials: MJ
authors.lastname: Heinig
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Brown
authors.forename: Bo
authors.initials: B
authors.lastname: Lönnerdal
authors.forename: Kathryn G
authors.initials: KG
authors.lastname: Dewey
mesh_terms: D000704:Analysis of Variance; D000886:Anthropometry; D001942:Breast Feeding; D016009:Chi-Square Distribution; D002657:Child Development / Q000187:drug effects* / Q000502:physiology; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006128:Growth / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D017053:Infection Control; D008297:Male; D008895:Milk, Human / Q000737:chemistry*; D009017:Morbidity; D009048:Motor Skills / Q000187:drug effects*; D015032:Zinc / Q000494:pharmacology*
chemical_list: D015032:Zinc