title: Solvent-induced amphiphilic molecular baskets: unimolecular reversed micelles with different size, shape, and flexibility.
abstract: Amphiphilic molecular baskets were obtained by attaching facially amphiphilic cholate groups to a covalent scaffold (calix[4]arene or 1,3,5-2,4,6-hexasubstituted benzene). In a solvent mixture consisting of mostly a nonpolar solvent (i.e., CCl4) and a polar solvent (i.e., DMSO), the hydrophilic faces of cholates turned inward to form a reversed-micelle-like conformer whose stability was strongly influenced by the number of the cholates and the topology of the scaffold. Preferential solvation of the hydrophilic faces of cholates within the molecule by the polar solvent was cooperative and gave the fundamental driving force to the conformational change. The reversed-micelle-like conformer was most stable in structures that allowed multiple cholates to form a microenvironment that could efficiently enrich the polar solvent molecules from the bulk solvent mixture.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA.
authors.forename: Eui-Hyun
authors.initials: EH
authors.lastname: Ryu
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.forename: Zhenqi
authors.initials: Z
authors.lastname: Zhong
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao