title: DyNAs: constitutional dynamic nucleic acid analogues.
abstract: Dynamic cationic polymers were generated in aqueous media from functionally complementary monomers bearing nucleobase groups. (1)H NMR spectroscopy was used to follow the polycondensation reaction of the nucleobase-appended dihydrazides 1 and 2 with the dialdehydes B and C. The reversibility of these polymers was established by proton NMR spectroscopy through exchange of the dihydrazide 2 with polymer 1 B. The polymers 1 B, 2 B, 1 C, and 2 C represent dynamic biopolymers of nucleic acid type, DyNAs. Electrostatic interaction of these polymers with polyanionic entities, such as polyphosphates, polynucleotides, and polyaspartic acid, was shown to take place. It induces a change in size of the dynamic polymer, as it responds by an increase in degree of polymerization to an increase of the overall anionic charge introduced, that is, to the total electrostatic interaction.
authors.affiliation: Institut de Science et d'Ingénierie Supramoléculaires, Université Louis Pasteur, 8 Allée Gaspard Monge, 67000 Strasbourg, France.
authors.forename: Nampally
authors.initials: N
authors.lastname: Sreenivasachary
authors.forename: David T
authors.initials: DT
authors.lastname: Hickman
authors.forename: Dominique
authors.initials: D
authors.lastname: Sarazin
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Lehn
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009696:Nucleic Acids / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry; D055672:Static Electricity; D013997:Time Factors
chemical_list: D000447:Aldehydes; D000838:Anions; D002412:Cations; D006834:Hydrazines; D009696:Nucleic Acids; D010455:Peptides; D011108:Polymers; D011122:Polyphosphates; C017645:polyaspartate; C029424:hydrazine