title: Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy.
abstract: We investigated an association between olfaction and cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD.
authors.affiliation: Department of Neurology, Ajou University College of Medicine, Suwon, South Korea. phisland@chol.com
authors.forename: Phil Hyu
authors.initials: PH
authors.lastname: Lee
authors.forename: Seung Hyeon
authors.initials: SH
authors.lastname: Yeo
authors.forename: Hyun Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hyo Young
authors.initials: HY
authors.lastname: Youm
mesh_terms: D019797:3-Iodobenzylguanidine / Q000737:chemistry*; D000368:Aged; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009812:Odorants; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012903:Smell / Q000187:drug effects / Q000502:physiology*; D013223:Statistics as Topic
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine