title: Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy.
abstract: We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/epsilon2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95% confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95% CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95% CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.
authors.affiliation: Laboratory of Geriatrics and Gerontology, Research Department, IRCCS Casa Sollievo della Sofferenza, Viale San Giovanni Rotondo, Italy. dseripa@operapadrepio.it
authors.forename: Davide
authors.initials: D
authors.lastname: Seripa
authors.forename: Marilisa
authors.initials: M
authors.lastname: Franceschi
authors.forename: Maria G
authors.initials: MG
authors.lastname: Matera
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Kehoe
authors.forename: Carolina
authors.initials: C
authors.lastname: Gravina
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Orsitto
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Solfrizzi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Minno
authors.forename: Bruno
authors.initials: B
authors.lastname: Dallapiccola
authors.forename: Alberto
authors.initials: A
authors.lastname: Pilotto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D006823:Hybrid Vigor; D007558:Italy; D016015:Logistic Models; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors
chemical_list: D001057:Apolipoproteins E; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A