title: Measurement of cardiac output by open-circuit acetylene uptake: a computer model to quantify error caused by ventilation-perfusion inequality.
abstract: The ability to assess cardiac output (Q(T)) noninvasively has been the focus of interest for many researchers. While the open-circuit acetylene (C2H2) method seems promising, it is prone to error due to ventilation-perfusion (V/Q) inequality. Measurements during exercise, at high altitude or in patients with chronic obstructive pulmonary disease (COPD) could be unreliable and further validation studies under these circumstances may be needed. We used a computer model based on formulae derived from the multiple inert gas elimination technique to quantify error in Q(T) measurements resulting from V/Q inequality at rest, during exercise or at high altitude. Moreover, potential errors encountered in patients with COPD were quantified. In healthy subjects, V/Q inequality related measurement error seems negligible, under both normoxic and hypoxic conditions and especially during exercise. In COPD, errors up to 20% at rest and up to 15% during exercise are expected. It is therefore concluded from our model that the open-circuit C2H2 uptake method is expected to be accurate in normal subjects. Its validity in COPD needs further study.
authors.affiliation: Department of Pulmonary Medicine, Academic Medical Center, F4-208, PO Box 22660, 1100 DD Amsterdam, The Netherlands.
authors.forename: Harm J
authors.initials: HJ
authors.lastname: Bogaard
authors.forename: Peter D
authors.initials: PD
authors.lastname: Wagner
mesh_terms: D000114:Acetylene; D002302:Cardiac Output / Q000502:physiology*; D003198:Computer Simulation; D015444:Exercise / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008954:Models, Biological; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology; D014692:Ventilation-Perfusion Ratio / Q000502:physiology*
chemical_list: D000114:Acetylene