[Spermatozoon mitochondrial DNA].
Mitochondria play a primary role in cellular energetic metabolism, homeostasis and death. In spermatozoa, in particular, mitochondria produce the ATP necessary for motility. Mitochondrial functions depend, at least partially, on mitochondrial DNA (mtDNA). The mitochondrial genome, the transmission of which is exclusively maternal contributes to cytoplasmic heredity. Qualitative and quantitative mtDNA abnormalities have been associated with male infertility. This review focuses on the role of mtDNA in human fertility.
May-Panloup
P
P
Département de pathologie cellulaire et tissulaire, Inserm U694, pôle de biologie, CHU, 49033 Angers, France. pamaypanloup@chu-angers.fr
Chrétien
M-F
MF
Malthiery
Y
Y
Reynier
P
P
D004272:DNA, Mitochondrial / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D006801:Humans; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D008928:Mitochondria / Q000502:physiology; D009154:Mutation; D013094:Spermatozoa / Q000737:chemistry* / Q000648:ultrastructure*
D004272:DNA, Mitochondrial