title: Outcomes of renal transplantation for recipients with lupus nephritis: analysis of the Organ Procurement and Transplantation Network database.
abstract: Prior analyses of transplant outcomes in lupus transplant recipients have not consisted of multivariate analyses in the modern immunosuppressive era. Here, we compared patient and graft outcomes in lupus and non-lupus recipients transplanted between 1996 to 2000 using the United Network of Organ Sharing/Organ Procurement Transplant Network database. We evaluated the impact of recipient and donor demographic factors, time on dialysis and the initial immunosuppression regimen on rejection rates and transplant outcomes. Univariate analysis showed similar graft but better patient survival rates for primary lupus and non-lupus transplant recipients (5-year patient survival rates for lupus cohort 85.2% for deceased donor transplants and 92.1% for living donor transplants as opposed to 82.1% and 89.8% respectively for the non-lupus cohort; P=0.05 and 0.03) but similar patient survival rates for deceased donor retransplant patients. After controlling for confounding factors, no differences in patient or graft survival were seen between the two groups. No difference in acute rejection rates were observed in deceased donor transplants, but there was a small but significant increase in the risk of acute rejection in living donor lupus transplant recipients (hazard ratio=1.19, P=0.05). Risk of graft failure was lower for deceased donor recipients receiving MMF (five-year graft loss rate=29.6% for MMF vs. 40.2% for those not receiving MMF, P<0.0001), but no differences were seen among living donor recipients. Outcomes were similar regardless of type of calcineurin inhibitor, induction therapy, and time on dialysis. We conclude that lupus transplant recipients have outcomes generally equivalent to non-lupus transplant recipients.
authors.forename: Suphamai
authors.initials: S
authors.lastname: Bunnapradist
authors.forename: Philip
authors.initials: P
authors.lastname: Chung
authors.forename: Alice
authors.initials: A
authors.lastname: Peng
authors.forename: Andy
authors.initials: A
authors.lastname: Hong
authors.forename: Peter
authors.initials: P
authors.lastname: Chung
authors.forename: Brian
authors.initials: B
authors.lastname: Lee
authors.forename: Sumina
authors.initials: S
authors.lastname: Fukami
authors.forename: Steven K
authors.initials: SK
authors.lastname: Takemoto
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Singh
mesh_terms: D000328:Adult; D000368:Aged; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology* / Q000706:statistics & numerical data*; D008181:Lupus Nephritis / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D014481:United States