title: Multi-country study on the prevalence and clinical features of peripheral arterial disease in Asian type 2 diabetes patients at high risk of atherosclerosis.
abstract: OBJECTIVE
  PAD-SEARCH was the first international study to investigate the prevalence of peripheral arterial disease (PAD) in Asian type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD.
  
  
  METHODS
  In total 6625 type 2 diabetic patients aged 50 and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in Korea, China, Taiwan, Hong Kong, Indonesia, Thailand and the Philippines.
  
  
  RESULTS
  Mean patient age was 63.7+/-8.2 years and mean duration of diabetes was 10.3+/-8.0 years. One thousand one hundred and seventy-two (17.7%) subjects were diagnosed as PAD by ABI (< or =0.9). PAD subjects had a significantly longer duration of diabetes, hypertension, higher HbA1c, and a significantly lower mean BMI than non-PAD subjects. In terms of lipid profiles, triglyceride was the only significant variable. Notably, mean ABI and baPWV in females were significantly poorer than age matched males in subjects with a normal ABI. However, mean ABI and baPWV in males were significantly poorer than in age matched females in subjects with PAD.
  
  
  CONCLUSIONS
  These findings suggest that PAD is a common complication in Asian type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for Asian diabetic patients with high risk factors.
authors.affiliation: Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Sang Youl
authors.initials: SY
authors.lastname: Rhee
authors.forename: Heng
authors.initials: H
authors.lastname: Guan
authors.forename: Zhi Min
authors.initials: ZM
authors.lastname: Liu
authors.forename: Stephen Wing-Keung
authors.initials: SW
authors.lastname: Cheng
authors.forename: Sarwono
authors.initials: S
authors.lastname: Waspadji
authors.forename: Patricio
authors.initials: P
authors.lastname: Palmes
authors.forename: Tong Yuan
authors.initials: TY
authors.lastname: Tai
authors.forename: Sompongse
authors.initials: S
authors.lastname: Suwanwalaikorn
authors.forename: Young Seol
authors.initials: YS
authors.lastname: Kim
mesh_terms: D017677:Age Distribution; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015999:Multivariate Analysis; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology / Q000503:physiopathology*; D015995:Prevalence; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D006442:Glycated Hemoglobin; D014280:Triglycerides