A clonal translocation (7;8)(p13;q11.2) in a leiomyoma of the vulva.
We present the first case of a vulvar leiomyoma studied by cytogenetics. The tumor formed a 3.0-cm periurethral nodule in a middle-aged woman and was positive for the muscle markers desmin and caldesmon, and for estrogen and progesterone receptors. Its karyotype was 46,XX,t(7;8)(p13;q11.2). This translocation has not been described in previously reported leiomyomas, regardless of their site of origin. The transcription factor PLAG1 gene at 8q12 was not altered by the translocation.
Horton
Elaine
E
Department of Pathology, Scott and White Memorial Hospital and Clinic, Scott, Sherwood and Brindley Foundation, 2401 South 31st Street, Temple, TX, USA.
Dobin
Sheila M
SM
Debiec-Rychter
Maria
M
Donner
Ludvik R
LR
D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic; D014846:Vulvar Neoplasms / Q000235:genetics*