title: Aspirin reduces platelet aggregation during high-energy excimer laser.
abstract: OBJECTIVE
  Excimer laser is used clinically in arterial revascularization procedures. This study evaluated the efficacy of aspirin in reducing platelet aggregation during high-energy excimer lasing.
  
  
  METHODS
  Platelet rich plasma (PRP) from seven rabbits was circulated in a dual organ chamber with aspirin added to one and the other was control. PRP was irradiated using an excimer laser (308 nm; 45 mJ/mm(2); 25 Hz; 5 minutes) via a 2.0 mm laser catheter. Platelet aggregation (particle volume) was measured by laser-light scattering. Morphology was evaluated by phase contrast and electron microscopy.
  
  
  RESULTS
  Baseline platelet volume was 3.4 microm(3) for both control and aspirin groups. Following lasing, platelet volume peaked at 102.2 +/- 18.5 microm(3) for control compared to 43.1 +/- 49.2 microm(3) for aspirin-treated PRP (P < 0.0001).
  
  
  CONCLUSIONS
  Aspirin reduces large platelet aggregates but not small aggregates by 58% during lasing of PRP.
authors.affiliation: Division of Cardiology, Department of Medicine, Michigan State, University, East Lansing, Michigan 48824, USA.
authors.forename: Ruiping
authors.initials: R
authors.lastname: Huang
authors.forename: Roshan B
authors.initials: RB
authors.lastname: Patel
authors.forename: Hongbao
authors.initials: H
authors.lastname: Ma
authors.forename: Kevin
authors.initials: K
authors.lastname: Taylor
authors.forename: George S
authors.initials: GS
authors.lastname: Abela
mesh_terms: D000704:Analysis of Variance; D017222:Angioplasty, Balloon, Laser-Assisted; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D017536:Carotid Artery, Common / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004195:Disease Models, Animal; D010316:Particle Size; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010976:Platelet Count; D053657:Platelet-Rich Plasma / Q000187:drug effects; D011817:Rabbits
chemical_list: D015415:Biomarkers; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin