title: Laryngeal preservation in head and neck cancer: multidisciplinary approach.
abstract: Since the first total laryngectomy was undertaken, efforts have been made to avoid removing the entire larynx. For a long time, partial surgery and radiotherapy were the only options that could preserve the larynx. Development of active chemotherapy regimens has prompted an era of intensive clinical research. Induction chemotherapy followed by radiotherapy in patients with objective responses has been shown to allow conservation of the larynx in nearly two-thirds of individuals, without any effect on survival; concurrent chemoradiotherapy also provides high rates of laryngeal preservation, again without affecting survival; and induction chemotherapy followed by concurrent chemoradiotherapy is under investigation. In the meantime, partial open surgery and endoscopic carbon dioxide laser procedures are feasible in selected moderately advanced laryngopharyngeal cancers as an alternative to destructive surgery. Altered fractionation radiotherapy can also be used in management of these tumours, and targeted treatments have opened a new area of clinical research. Findings of basic research and modern imaging should provide useful approaches for selection of patients for various strategies.
authors.affiliation: Head and Neck Department, Centre Oscar Lambret, 3 rue Combemale, 59020 Lille, France. jl-lefebvre@o-lambret.fr
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Lefebvre
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000503:physiopathology / Q000628:therapy*; D007825:Laryngectomy; D007830:Larynx / Q000503:physiopathology*
chemical_list: D000970:Antineoplastic Agents