title: [Aspirin resistance theory].
abstract: Acetylsalicylic acid is an effective antiplatelet drug for primary and secondary prevention of heart and brain vascular diseases. Analyses of trials including patients with atherosclerosis proved that vascular ischaemic events have been reduced by 25% and risk of vascular death has been reduced due to aspirin. The increasing number of reports about aspirin resistance (the failure of the compound to protect from an ischemic event despite regular intake of appropriate doses) is alarming. The purpose of this review is to present current opinions and results of investigations connected with this problem.
authors.affiliation: Katedra i Klinika Neurologii, Slaska Akademia Medyczna, ul. 3 Maja 13/15, 41-800 Zabrze. aleksandraporosinska@tlen.pl
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Porosińska
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pierzchała
mesh_terms: D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D002986:Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D002546:Ischemic Attack, Transient / Q000517:prevention & control; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D016861:Cyclooxygenase Inhibitors; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin