title: Changes in LORETA and conventional patterns of P600 after steroid treatment in multiple sclerosis patients.
abstract: OBJECTIVE
  The P600 component of event-related potentials (ERPs) reflecting the 'rule-governed sequence of information processing', has been associated with multiple sclerosis (MS)-related cognition. The present study aimed at examining the effects of methylprednisolone treatment in MS patients on cognition as reflected by the low-resolution brain electromagnetic tomography (LORETA) of the P600 as well as its conventional constituents (amplitudes and latencies) recorded during a working memory (WM) test.
  
  
  METHODS
  A paired LORETA comparison was performed in the P600 component of ERPs elicited during a (WM) test in 18 MS patients suffering from the relapsing-remitting form, before and after 1 week treatment with methylprednisolone. The P600 component was also evaluated in 16 healthy controls matched to the patients on age and educational level.
  
  
  RESULTS
  When pre- and post-treatment recordings of LORETA were compared all patients as a group showed significantly different patterns of current density activation located at right frontal lobe. The treatment was accompanied by an increase of the amplitude of P600 at the right frontoparietal area. In the post-treatment phase the patients exhibited significant improvement of the memory performance as compared to themselves before treatment. As a result both the P600 amplitudes and memory performance at post-treatment were closer to those exhibited by normal controls.
  
  
  CONCLUSIONS
  These findings support the notion that steroid treatment in relapsing-remitting MS patients, may exert a beneficial effect in 'rule-governed sequence of information processing'.
authors.affiliation: Department of Psychiatry, Eginition Hospital, University of Athens, 74 Vas. Sophias Ave., Athens, 11528, Greece. cpapage@eginitio.uoa.gr
authors.forename: Charalabos C
authors.initials: CC
authors.lastname: Papageorgiou
authors.forename: Costas
authors.initials: C
authors.lastname: Sfagos
authors.forename: Katerina K
authors.initials: KK
authors.lastname: Kosma
authors.forename: Kostantinos A
authors.initials: KA
authors.lastname: Kontoangelos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Triantafyllou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Vassilopoulos
authors.forename: Andreas D
authors.initials: AD
authors.lastname: Rabavilas
authors.forename: Constantin R
authors.initials: CR
authors.lastname: Soldatos
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008775:Methylprednisolone / Q000627:therapeutic use; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D013256:Steroids / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids; D008775:Methylprednisolone