Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats.
In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.
Tanaka
Mitsuru
M
Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Matsui
Toshiro
T
Ushida
Yusuke
Y
Matsumoto
Kiyoshi
K
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000502:physiology; D004151:Dipeptides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D000959:Antihypertensive Agents; D004151:Dipeptides; D014665:Vasodilator Agents; C493687:isoleucyl-tyrosine; C414029:valyltyrosine