Photochemical and thermal reactivity of kynurenine.
The thermal and photochemical reactivity of kynurenine (KN), a tryptophan metabolite found in human lenses, has been studied in aqueous solution. The decarboxylation reaction of KN, resulting in the formation of 4-hydroxyquinoline, is reported for the first time. Rate constants for KN deamination and decarboxylation were determined in the temperature range 50-90 degrees C. The quantum yields for KN photodecomposition under argon were measured to be Phi Ar=(2.0+/-0.2) x 10(-5) and under oxygen Phi O2=(1.1+/-0.1) x 10(-4).
Tsentalovich
Yuri P
YP
Department of Multispin Coordination Compounds, International Tomography Center, Institutskaya 3a, Novosibirsk, Russia. yura@tomo.nsc.ru
Snytnikova
Olga A
OA
Forbes
Malcolm D E
MD
Chernyak
Elena I
EI
Morozov
Sergey V
SV
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003641:Deamination; D003653:Decarboxylation; D006358:Hot Temperature; D006801:Humans; D007737:Kynurenine / Q000737:chemistry* / Q000528:radiation effects; D010084:Oxidation-Reduction; D010777:Photochemistry; D010782:Photolysis; D013696:Temperature
D007737:Kynurenine