No differences in the DNA methylation pattern in mouse zygotes produced in vivo, in vitro, or by intracytoplasmic sperm injection.
The pattern and degree of pronuclear DNA methylation has been evaluated in naturally, in in vitro, or in intracytoplasmic sperm injection (ICSI)-produced mouse embryos. The results show no differences between all experimental groups and confirm the relative safety of IVF and ICSI.
Fulka
Helena
H
Department of Cell Ultrastructure and Molecular Biology, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.
Fulka
Josef
J
D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000235:genetics*; D051379:Mice; D008813:Mice, Inbred ICR; D020554:Sperm Injections, Intracytoplasmic; D015053:Zygote / Q000166:cytology* / Q000502:physiology*
D004247:DNA