title: Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome.
abstract: The insulin autoimmune syndrome is characterized as producing polyclonal or monoclonal anti-insulin autoantibodies in a patient with no previous history of exposure to exogenous insulin. The patient is 44-year-old Japanese woman and she had symptoms of hypoglycaemia without exposure to exogenous insulin. The patient was considered to have IAS because high titre of anti-insulin autoantibodies (96-98%: bound/total) were found in her serum. Her HLA DR beta1 DNA sequences analysis revealed that she has the DRB1(*)0406 and DRB1(*)0901. Our patient have been taken alpha lipoic acid (ALA) before onset. SH group compounds are known to play an important role in the pathogenesis of IAS, and ALA contains SH. From these data, we propose the possibility of the correlation between pathogenesis of IAS and ALA, and it will be important to pay attention for ALA as a cause of hypoglycemia in such cases.
authors.affiliation: Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Furukawa
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Miyamura
authors.forename: Kenro
authors.initials: K
authors.lastname: Nishida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Motoshima
authors.forename: Kayo
authors.initials: K
authors.lastname: Taketa
authors.forename: Eiichi
authors.initials: E
authors.lastname: Araki
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood / Q000209:etiology*; D001786:Blood Glucose / Q000032:analysis; D019587:Dietary Supplements; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood; D059811:HLA-DRB1 Chains; D006801:Humans; D007328:Insulin / Q000097:blood*; D008063:Thioctic Acid / Q000009:adverse effects*
chemical_list: D001786:Blood Glucose; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D007328:Insulin; D008063:Thioctic Acid