A gold(I) complex with a vitamin K3 derivative: characterization and antitumoral activity.
Reaction of the vitamin K(3) derivative menadione sodium bisulfite thiosemicarbazone (NaK(3)TSC) with chloro(triethylphosphine)gold(I) afforded the complex [AuPEt(3)(K(3)TSC)]. This compound consists of discrete molecules in which the metal is almost linearly coordinated to P and S. Preliminary in vitro screening showed significant anti-cancer activity, notably against the cisplatin-resistant cell line A2780cis.
Casas
José S
JS
Departamento de Química Inorgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain. qiscasas@usc.es <qiscasas@usc.es>
Castellano
Eduardo E
EE
Couce
María D
MD
Ellena
Javier
J
Sánchez
Agustín
A
Sordo
José
J
Taboada
Carmen
C
D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D050607:Organogold Compounds / Q000737:chemistry* / Q000494:pharmacology; D024483:Vitamin K 3 / Q000737:chemistry*
D050607:Organogold Compounds; C447642:chloro(triethylphosphine)gold(I); D024483:Vitamin K 3; D002945:Cisplatin