title: Activity of quinones from teak (Tectona grandis) on fungal cell wall stress.
abstract: Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By (1)H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of 1,3 -alpha-D-glucan synthase were used as a cell wall damage model. The result showed that deoxylapachol from T. grandis extract induced fungal cell wall stress.
authors.affiliation: Division of Pharmacognosy, Section Metabolomics, Gorlaeus Laboratories, Institute of Biology, Leiden University, Leiden, The Netherlands.
authors.forename: Pattarawadee
authors.initials: P
authors.lastname: Sumthong
authors.forename: Robbert A
authors.initials: RA
authors.lastname: Damveld
authors.forename: Young H
authors.initials: YH
authors.lastname: Choi
authors.forename: Mark
authors.initials: M
authors.lastname: Arentshorst
authors.forename: Arthur F
authors.initials: AF
authors.lastname: Ram
authors.forename: Cees A
authors.initials: CA
authors.lastname: van den Hondel
authors.forename: Rob
authors.initials: R
authors.lastname: Verpoorte
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D002473:Cell Wall / Q000187:drug effects*; D002845:Chromatography; D019686:Lamiaceae / Q000737:chemistry*; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology; D030781:Organisms, Genetically Modified / Q000254:growth & development; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D009285:Naphthoquinones; D010936:Plant Extracts; D011809:Quinones; C044416:deoxylapachol