[Evaluation of therapeutic intervention on bone mass and turnover through monitoring of biochemical markers of bone turnover].
Monitoring of biochemical markers of bone turnover has brought about a number of breakthroughs in the area of osteoporosis management. Of these, the following three are of particular interest: 1) monitoring of these biochemical markers represents the only clinical means available for assessment of bone quality: 2) it helps grasp the patient's condition, as well as predicts the patient's risk for developing fractures: and 3) it allows the effect of therapeutic intervention to be evaluated at an earlier stage than bone mineral density. Thus, monitoring of these biochemical markers not only helps strengthen motivation among healthcare professionals for osteoporosis treatment, but also helps enhance patient compliance to treatment.
Ohta
Hiroaki
H
Department of Obstetrics and Gynecology, Tokyo Women's Medical University.
D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000032:analysis*; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000652:urine; D006801:Humans; D008991:Monitoring, Physiologic; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D010455:Peptides / Q000652:urine
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase