title: [A case of N3 gastric cancer successfully treated by TS-1 followed by curative resection].
abstract: We report a case of N 3 gastric cancer successfully treated by TS-1 followed by curative resection. The patient was a 64-year-old male. Gastrointestinal endoscopic examination showed advanced gastric cancer. Examination by computed tomography revealed gastric cancer and swollen para-aortic lymph nodes. This patient was treated by neoadjuvant chemotherapy with oral administration of TS-1 (120 mg/day, day 1-28 with 2 weeks rest). After 3 courses of TS-1, the primary lesion and swollen lymph nodes were remarkably reduced. This chemotherapy enabled pancreatoduodenectomy with D 3 lymph node dissection in curative resection. The pathological diagnosis was por, pT 2, pMP and pap, pT 1, pSM 2, pPM(-), pDM(-), pN 1, pStage II and curability A. This neoadjuvant chemotherapy regimen seems to be an effective and promising therapy for patients with advanced gastric cancer.
authors.affiliation: Dept. of Surgery, Sasebo City General Hospital.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yoshida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Sumida
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hara
authors.forename: Masamichi
authors.initials: M
authors.lastname: Kondou
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashizume
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tokunaga
authors.forename: Ryoutarou
authors.initials: R
authors.lastname: Kamohara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Minami
authors.forename: Keisuke
authors.initials: K
authors.lastname: Iwasaki
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000284:Administration, Oral; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage*; D016577:Pancreaticoduodenectomy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid