Synthesis of analogues of anthraquinones linked to tuftsin or retro-tuftsin residues as potential topoisomerase inhibitors.
A novel group of [(4-, 5- or 8)-hydroxy-9,10-anthraquinone-1-yl]-(tuftsin or retro-tuftsin) acids and methyl esters has been synthesized as potential anticancer compounds. The corresponding protected tuftsin or retro-tuftsin derivatives were also synthesized. We hope that combining compounds of different mechanisms of action will improve their clinical properties, and that our new analogues will be much more effective against multidrug-resistant tumour cell lines.
Dzierzbicka
K
K
Department of Chemical Faculty, Gdańsk University of Technology, 11/12 G. Narutowicza Street, 80-952 Gdańsk, Poland. kd@chem.pg.gda.pl
Sowinski
P
P
Kołodziejczyk
A M
AM
D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D059003:Topoisomerase Inhibitors; D014405:Tuftsin / Q000737:chemistry*
D000880:Anthraquinones; D004791:Enzyme Inhibitors; D059003:Topoisomerase Inhibitors; D014405:Tuftsin