title: Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms.
abstract: BACKGROUND
  Cutaneous leiomyomas and leiomyosarcomas are rare tumors that originate from the arrector muscle of hair follicles or the smooth muscle of blood vessels.
  
  
  METHODS
  A 74-year-old male presented with a single, erythematous nodule on the left upper arm. This lesion developed within the excision scar of a piloleiomyoma that had been excised 3 years ago. Additionally, physical examination revealed a tender nodule on the right ear.
  
  
  RESULTS
  Histological examination showed a cutaneous leiomyosarcoma with myxoid alteration on the upper arm and an angioleiomyoma on the right ear.
  
  
  CONCLUSIONS
  Myxoid leiomyosarcomas have exclusively been reported in the uterus and gastrointestinal tract, but not in the skin. Here, we describe a case of cutaneous leiomyosarcoma with myxoid alteration that developed in the excision scar of a piloleiomyoma and was accompanied by a cutaneous angioleiomyoma in a different location.
authors.affiliation: Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany. jochen.utikal@haut.ma.uni-heidelberg.de
authors.forename: Jochen
authors.initials: J
authors.lastname: Utikal
authors.forename: Georg
authors.initials: G
authors.lastname: Haus
authors.forename: Nina
authors.initials: N
authors.lastname: Poenitz
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Koenen
authors.forename: Walter
authors.initials: W
authors.lastname: Back
authors.forename: Edgar
authors.initials: E
authors.lastname: Dippel
authors.forename: Alexei
authors.initials: A
authors.lastname: Gratchev
authors.forename: Sergij
authors.initials: S
authors.lastname: Goerdt
mesh_terms: D000368:Aged; D018229:Angiomyoma / Q000473:pathology* / Q000601:surgery; D002921:Cicatrix / Q000473:pathology; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D018235:Smooth Muscle Tumor / Q000473:pathology*