title: Cat allergen level: its determinants and relationship to specific IgE to cat across European centers.
abstract: BACKGROUND
  Cat allergen level in settled house dust and its determinants in Europe are unknown.
  
  
  OBJECTIVE
  The aim of this study is to quantify the level of cat allergens in mattress dust, to study its determinants, and to analyze the relationship with cat specific IgE on community level across European centers.
  
  
  METHODS
  Trained field workers collected dust from approximately 3000 mattresses during home visits in 22 European Community Respiratory Health Survey II centers. Sieved dust extracts were assayed for cat allergen using a mAb ELISA assay.
  
  
  RESULTS
  The overall geometric mean cat allergen was 0.94 microg/g, ranging from 0.12 microg/g in Huelva, Spain, to 3.76 microg/g in Antwerp, Belgium. Current cat owners' homes showed substantially higher levels than past cat owners' and never cat owners' homes (geometric mean and 95% CI, 61.4 microg/g [48.4-77.9] vs 1.37 microg/g [0.97-1.9] vs 0.29 microg/g [0.27-0.31]). Community prevalence of cat ownership was moderately correlated with cat allergen levels in noncat owners (r(s) = 0.50), but not for past or current cat owners. The multilevel model identified community prevalence of cat keeping as the only statistically significant determinant of mattress cat allergen levels for noncat owners. However, averaged cat allergen levels per center were not related to community prevalence of detectable specific IgE to cat.
  
  
  CONCLUSIONS
  Not having a cat in the home is associated with substantially lower Fel d 1 concentration, but does not protect against high Fel d 1 exposure in communities where cat ownership is common.
  
  
  CONCLUSIONS
  People (including patients with cat allergy) who do not own cats may be exposed to high levels of cat allergen in their home, particularly if they live in communities with high levels of cat ownership.
authors.affiliation: GSF, National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany. joachim.heinrich@gsf.de
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
authors.forename: Getahun Bero
authors.initials: GB
authors.lastname: Bedada
authors.forename: Jan-Paul
authors.initials: JP
authors.lastname: Zock
authors.forename: Susan
authors.initials: S
authors.lastname: Chinn
authors.forename: Dan
authors.initials: D
authors.lastname: Norbäck
authors.forename: Mario
authors.initials: M
authors.lastname: Olivieri
authors.forename: Cecilie
authors.initials: C
authors.lastname: Svanes
authors.forename: Michela
authors.initials: M
authors.lastname: Ponzio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Verlato
authors.forename: Simona
authors.initials: S
authors.lastname: Villani
authors.forename: Deborah
authors.initials: D
authors.lastname: Jarvis
authors.forename: Christina
authors.initials: C
authors.lastname: Luczynska
mesh_terms: D000485:Allergens / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D000829:Animals, Domestic / Q000276:immunology*; D000918:Antibody Specificity; D001513:Beds; D002415:Cats / Q000276:immunology*; D003430:Cross-Sectional Studies; D004391:Dust / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005060:Europe; D006023:Glycoproteins / Q000276:immunology* / Q000378:metabolism; D006798:Housing; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D011795:Surveys and Questionnaires
chemical_list: D000485:Allergens; D004391:Dust; D000939:Epitopes; D006023:Glycoproteins; D007073:Immunoglobulin E; C059296:Fel d 1 protein, Felis domesticus