Effect on survival of the development of late-onset non-infectious pulmonary complications after stem cell transplantation.
We evaluated the incidence, risk factors, and clinical outcome of late-onset non-infectious pulmonary complications (LONIPC) in 599 patients who underwent hematopoietic allogeneic stem cell transplantation (HSCT). The 2-year cumulative incidence of LONIPC was 10% among the 438 patients surviving more than 3 months after HSCT. Transplants from an unrelated donor and occurrence of extensive chronic graft-versus-host disease were the variables significantly associated with the development of LONIPC. The 5-year overall survival was significantly worse among patients with LONIPC than among those without (34% vs 65%, p=0.009). Causes of death were respiratory failure and infections. The relapse rate was similar in the two groups.
Patriarca
Francesca
F
Division of Haematology, Transplantation Unit and Cellular Therapies Carlo Melzi, Department of Clinical and Morphological Research, University Hospital of Udine. francesca.patriarca@med.uniud.it
Skert
Cristina
C
Bonifazi
Francesca
F
Sperotto
Alessandra
A
Fili
Carla
C
Stanzani
Marta
M
Zaja
Francesco
F
Cerno
Michela
M
Geromin
Antonella
A
Bandini
Giuseppe
G
Baccarani
Michele
M
Fanin
Renato
R
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008171:Lung Diseases / Q000209:etiology* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate