title: Effects of alpha-substitutions on structure and biological activity of anticancer chalcones.
abstract: Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different alpha-substitutions, in particular alpha-fluorination, on the structure and biological activity of a series of chalcones.
authors.affiliation: Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612-9497, USA. Lawrennj@moffitt.usf.edu
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Lawrence
authors.forename: Richard P
authors.initials: RP
authors.lastname: Patterson
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Ooi
authors.forename: Darren
authors.initials: D
authors.lastname: Cook
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ducki
mesh_terms: D050256:Antimitotic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D020014:K562 Cells; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
chemical_list: D050256:Antimitotic Agents; D000970:Antineoplastic Agents; D014404:Tubulin; D002599:Chalcone