[Change of concentration of L-carnitine in blood and other tissues in rats on a background of the alcohol intake and influence of mildronate on its level].
Mildronate is an antiischemic drug. It inhibits carnitine biosynthesis (suppresses beta-oxidation of fatty acid) The aim of the study was to establish how Mildronate influences the concentration of L-carnitine in blood and in some tissues in rats with various stages chronic consumption of alcohol. 28 white rats instead of drinking water were taking 15 % ethanol. In the group A the rats were on the three-week alcohol consumption, in the group B--after 3 weeks of alcohol consumption on a background of alcohol they were taking the mildronate, group C--four-week alcohol consumption; D--after 4 weeks of alcohol consumption only mildronate was administered. The concentration of L-carnitine in the group A was as follows: in the liver 136.11+/-2.44; in heart 74.3+/-3.15; in brain 60.44+/-5.21; in blood 45.8+/-2.32. In the group B: in liver 115.7+/-4.69; in heart 72.11+/-4.23; in brain 59.23+/-2.44; in blood 62.5+/-1.99. In the group C: in liver 107.71+/-1.43; in heart 52.57+/-0.95; in brain 71.5+/-1.08; in blood 38.8+/-2.32. And in group D: in liver 106.94+/-1.81; in heart 42.04+/-0.88; in brain 56.84+/-2.75; in blood 2.37+/-0.69 (nmol/l). During the chronic use of alcohol the decrease of concentration of L-carnitine is marked. The level of L-carnitine is reduced under influence of alcohol, but at the same time it suppressed also all steps of metabolism of the cells. Mildronate not only suppresses carnitine-dependent oxidation, but also switches metabolism to more favorable aerobic glycolysis. Under the influence of mildronate general condition of the body is improved both during complete acceptance of alcohol, and on the background of continuation of consumption of alcohol.
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D000437:Alcoholism / Q000097:blood* / Q000378:metabolism*; D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002331:Carnitine / Q000097:blood* / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002317:Cardiovascular Agents; D008763:Methylhydrazines; D000431:Ethanol; C050147:3-(2,2,2-trimethylhydrazine)propionate; D002331:Carnitine