Estimation of radiation dose at various depths for commonly used radionuclides in radiosynoviorthesis in a tissue equivalent material.
The purpose of the paper is to report on the dose estimation studies at various depths for the commonly used beta-emitting 90Y, 166Ho, 153Sm, 32p, and 177Lu radionuclides in a phantom fabricated using the poly methyl methacrylate tissue equivalent material having a density of 1.19 gm/cc, by using thermoluminescent dosemeters. GAFChromic MD-55 films were used to calculate the calibration factor for the thermoluminescent micro-rods used in our study. It is observed that 90Y delivers the highest dose at 1 mm amongst the radionuclides tested followed by 32p, 166Ho, 153Sm, and 177Lu, whereas the cumulative dose received by the joint was found to be more for 32P followed by 90Y, 166Ho, 153Sm, and 177Lu. The highest therapeutic range obtained is 3.1 mm for 153Sm amongst the tested radionuclides. The dose values obtained for all the above-mentioned radionuclides can serve as reference material for those researchers and clinicians who are interested in selection of the radionuclide for the type of joint treated and the amount of dose necessary to be delivered to the synovial membrane.
Tandon
Pankaj
P
Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, CT&CRS Building, Anushaktinagar, Mumbai 400 094, India. pantan@gmail.com
Malpani
B L
BL
Venkatesh
Meera
M
Bhatt
B C
BC
D032701:Biomimetics / Q000295:instrumentation / Q000379:methods; D001822:Body Burden; D006801:Humans; D011868:Radioisotopes / Q000032:analysis* / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D012062:Relative Biological Effectiveness; D013583:Synovial Membrane / Q000528:radiation effects*; D013819:Thermoluminescent Dosimetry / Q000295:instrumentation* / Q000379:methods*
D011868:Radioisotopes