title: Antibody response to Pneumocystis jirovecii major surface glycoprotein.
abstract: We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii patients rose to a peak level 3-4 weeks (p<0.001) after recovery from pneumocystosis; baseline CD4+ count > or =50 cells/microL and first episode of pneumocystosis were the principal host factors associated with this rise (both p<0.001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies.
authors.affiliation: Research Service 151, Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220, USA.
authors.forename: Kieran R
authors.initials: KR
authors.lastname: Daly
authors.forename: Laurence
authors.initials: L
authors.lastname: Huang
authors.forename: Alison
authors.initials: A
authors.lastname: Morris
authors.forename: Judy
authors.initials: J
authors.lastname: Koch
authors.forename: Kristina
authors.initials: K
authors.lastname: Crothers
authors.forename: Linda
authors.initials: L
authors.lastname: Levin
authors.forename: Shary
authors.initials: S
authors.lastname: Eiser
authors.forename: Supriya
authors.initials: S
authors.lastname: Satwah
authors.forename: Patricia
authors.initials: P
authors.lastname: Zucchi
authors.forename: Peter D
authors.initials: PD
authors.lastname: Walzer
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology* / Q000382:microbiology; D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005656:Fungal Proteins / Q000276:immunology*; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology*; D008875:Middle Aged; D045363:Pneumocystis carinii / Q000276:immunology*; D011020:Pneumonia, Pneumocystis / Q000276:immunology* / Q000382:microbiology
chemical_list: D000908:Antibodies, Fungal; D005656:Fungal Proteins; D008562:Membrane Glycoproteins; C077556:GPA protein, Pneumocystis carinii sp.