title: Patterns of clinical presentation of adult coeliac disease in a rural setting.
abstract: BACKGROUND
  In recent years there has been increasing recognition that the pattern of presentation of coeliac disease may be changing. The classic sprue syndrome with diarrhoea and weight loss may be less common than the more subtle presentations of coeliac disease such as an isolated iron deficiency anaemia. As a result, the diagnosis of this treatable condition is often delayed or missed. Recent serologic screening tests allow non-invasive screening to identify most patients with the disease and can be applied in patients with even subtle symptoms indicative of coeliac disease. Both benign and malignant complications of coeliac disease can be avoided by early diagnosis and a strict compliance with a gluten free diet.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the trends in clinical presentation of patients diagnosed with adult coeliac disease. In addition, we studied the biochemical and serological features and the prevalence of associated conditions in patients with adult coeliac disease.
  
  
  METHODS
  This is an observational, retrospective, cross-sectional review of the medical notes of 32 adult patients attending the specialist coeliac clinic in a district general hospital.
  
  
  RESULTS
  Anaemia was the most common mode of presentation accounting for 66% of patients. Less than half of the patients had any of the classical symptoms of coeliac disease and 25% had none of the classical symptoms at presentation. Anti-gliadin antibodies, anti-endomysial antibody and anti-tissue transglutaminase showed 75%, 68% and 90% sensitivity respectively. In combination, serology results were 100% sensitive as screening tests for adult coeliac disease. Fifty nine percent patients had either osteoporosis or osteopenia. There were no malignant complications observed during the follow up of our patients.
  
  
  CONCLUSIONS
  Most adults with coeliac disease have a sub clinical form of the disease and iron deficiency anaemia may be its sole presenting symptom. Only a minority of adult coeliac disease patients present with classical mal-absorption symptoms of diarrhoea and weight loss. Patients with atypical form of disease often present initially to hospital specialists other than a gastro-enterologist. An awareness of the broad spectrum of presentations of adult coeliac disease, among doctors both in primary care and by the various hospital specialists in secondary care, is necessary to avoid delays in diagnosis. It is important to include serological screening tests for coeliac disease systematically in the evaluation of adult patients with unexplained iron deficiency anaemia or unexplained gastro-intestinal symptoms and in those who are considered to be at increased risk for coeliac disease.
authors.affiliation: Dietetics, Royal Gwent Hospital. Newport, Gwent, South Wales, UK. sian.jones2@gwent.wales.nhs.uk
authors.forename: Sián
authors.initials: S
authors.lastname: Jones
authors.forename: Charles
authors.initials: C
authors.lastname: D'Souza
authors.forename: Nadim Y
authors.initials: NY
authors.lastname: Haboubi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018798:Anemia, Iron-Deficiency; D001323:Autoantibodies / Q000097:blood; D015519:Bone Density; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D004909:Erythrocyte Indices; D005260:Female; D005293:Ferritins / Q000097:blood; D005492:Folic Acid / Q000097:blood; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007421:Intestine, Small / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000276:immunology; D010024:Osteoporosis / Q000150:complications; D012189:Retrospective Studies; D012424:Rural Population; D012871:Skin Diseases / Q000150:complications; D011503:Transglutaminases / Q000276:immunology; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D001323:Autoantibodies; D005293:Ferritins; D005903:Gliadin; D005492:Folic Acid; D011503:Transglutaminases; D014805:Vitamin B 12