title: [CAG repeats of DNA polymerase gamma in Chinese males and relationship of idiopathic male infertility to CAG repeats].
abstract: OBJECTIVE
  To analyze the polymerase gamma(Polg) gene polymorphisms in Chinese idiopathic infertile males and evaluate the correlation of the polymorphisms with male infertility.
  
  
  METHODS
  We conducted a study of Polg CAG repeats in the sperm or blood DNA of 55 asthenospermia patients, 57 oligospermia patients, 34 azoospermia patients, and 104 controls with PCR and GeneScan. Phenotypic data were available in all the subjects, including semen parameters, and clinical profiles.
  
  
  RESULTS
  The frequency of 10/not 10 CAG genotype in asthenospermia patients was higher than in the other groups, but with no significance.
  
  
  CONCLUSIONS
  Our findings have shown for the first time that there exits an ethnic difference between Chinese and European males in the number of CAG repeats of Polg gene, and that 10/not 10 CAG genotype may affect sperm motility.
authors.affiliation: Department of Medical Genetics, Peking Union Medical College, Beijing 100730, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yao
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Zheng
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Peng
authors.forename: Zuo-Xiang
authors.initials: ZX
authors.lastname: Li
authors.forename: Zuo-Qi
authors.initials: ZQ
authors.lastname: Peng
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Jin
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D018911:Trinucleotide Repeats
chemical_list: D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase