title: Cerebral glucose metabolism change in patients with complex regional pain syndrome: a PET study.
abstract: OBJECTIVE
  The aim of this study was to examine abnormalities of the central nervous system in patients with chronic pain who were diagnosed with complex regional pain syndrome (CRPS).
  
  
  METHODS
  Brain activity was assessed using (18)F-fluorodeoxyglucose positron emission tomography. The data collected from 18 patients were compared with data obtained from 13 normal age-matched controls.
  
  
  RESULTS
  Our results showed that glucose metabolism was bilaterally increased in the secondary somatosensory cortex, mid-anterior cingulated cortex (ACC) or posterior cingulated cortex (PCC) (or both), parietal cortex, posterior parietal cortex (PPC), and cerebellum as well as in the right posterior insula and right thalamus in our patients. In contrast, glucose metabolism was reduced contralaterally in the dorsal prefrontal cortex and primary motor cortex. Glucose metabolism was bilaterally elevated in the mid-ACC/PCC and the PPC, which correlated with pain duration.
  
  
  CONCLUSIONS
  These data suggested that glucose metabolism in the brains of patients with CRPS changes dramatically at each location. In particular, glucose metabolism was increased in the areas concerned with somatosensory perception, possibly due to continuous painful stimulation.
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Nagoya 466-8550, Japan. aaskog@hotmail.com
authors.forename: Satoe
authors.initials: S
authors.lastname: Shiraishi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nihashi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kato
authors.forename: Shingo
authors.initials: S
authors.lastname: Iwano
authors.forename: Masanari
authors.initials: M
authors.lastname: Nishino
authors.forename: Takeo
authors.initials: T
authors.lastname: Ishigaki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ikeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Kato
authors.forename: Kengo
authors.initials: K
authors.lastname: Ito
authors.forename: Tomomasa
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000378:metabolism*; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose