title: Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report.
abstract: Chronic intervillositis (CI) and massive perivillous fibrin deposition (MFD), together with its related entity, maternal floor infarction (MFI), are rare and poorly understood placental lesions. Both MFD/MFI and CI are associated with poor fetal outcome and high risk of recurrence. We report a patient who was found to have both MFD and CI in the same placenta, resulting in severe intrauterine fetal growth restriction and intrauterine fetal death at 37 weeks of gestation. Characteristic histological findings included both very extensive perivillous deposition of fibrinoid material and a heavy infiltrate of CD68-positive macrophages/monocytes in the maternal intervillous space. To our knowledge, this is the first time the co-occurrence of MFD and CI is reported in the literature.
authors.affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC-University Medical Center, Rotterdam, The Netherlands, and Department of Histopathology, Guy's and St Thomas' Hospital NHS Trust, London, UK.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Weber
authors.forename: Peter G J
authors.initials: PG
authors.lastname: Nikkels
authors.forename: Karen
authors.initials: K
authors.lastname: Hamoen
authors.forename: Johannes J
authors.initials: JJ
authors.lastname: Duvekot
authors.forename: Ronald R
authors.initials: RR
authors.lastname: de Krijger
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002824:Chorionic Villi / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000473:pathology; D005317:Fetal Growth Retardation / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D005337:Fibrin / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D010922:Placenta Diseases / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D021041:Placental Circulation; D011247:Pregnancy; D011248:Pregnancy Complications; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D005337:Fibrin; C067980:CD68 antigen, human; D000097382:CD68 Molecule