Agesamides A and B, bromopyrrole alkaloids from sponge Agelas species: application of DOSY for chemical screening of new metabolites.
Diffusion-ordered NMR spectroscopy (DOSY) is a versatile and powerful NMR technique and a noninvasive analytical method for mixture analysis that does not require prior physical separation of the analytes. In our search for new metabolites from natural resources, DOSY was applied for constituent analysis of crude bromopyrrole fractions separated from an Okinawan marine sponge Agelas sp. so that two new bromopyrrole alkaloids, agesamides A (1) and B (2), have been isolated. The structures and relative stereochemistry of 1 and 2 were elucidated from spectroscopic data.
Tsuda
Masashi
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Yasuda
Tetsuro
T
Fukushi
Eri
E
Kawabata
Jun
J
Sekiguchi
Mitsuhiro
M
Fromont
Jane
J
Kobayashi
Jun'ichi
J
D000818:Animals; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010879:Piperazines / Q000737:chemistry*; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
D010879:Piperazines; D011758:Pyrroles; C520896:agesamide A; C520897:agesamide B