Collagen solubility correlates with skin optical clearing.
Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.
Hirshburg
Jason
J
Choi
Bernard
B
Nelson
J Stuart
JS
Yeh
Alvin T
AT
D000818:Animals; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D051381:Rats; D012031:Refractometry / Q000379:methods*; D012542:Scattering, Radiation; D012867:Skin / Q000737:chemistry* / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology*; D012995:Solubility; D013223:Statistics as Topic
D003879:Dermatologic Agents; D003094:Collagen