title: Cross-over trials in Statistics in Medicine: the first '25' years.
abstract: Papers on cross-over trials that have appeared in the first 25 years of Statistics in Medicine are reviewed. Papers on bioequivalence are also considered. After a brief statistical summary, individual papers are discussed under seven headings: 1. The two-stage analysis of AB/BA trials, 2. Baselines, 3. Binary and categorical data, 4. Survival data, 5. Modelling carry-over, 6. Bioequivalence and 7. Components of variation. Finally, a brief assessment of the importance in this field of Statistics in Medicine is given.
authors.affiliation: Department of Statistics, University of Glasgow, Glasgow G12 8QQ, UK. stephen@stats.gla.ac.uk
authors.forename: Stephen
authors.initials: S
authors.lastname: Senn
mesh_terms: D018592:Cross-Over Studies; D018156:Journalism, Medical; D014481:United States