title: Increased risk of papillary thyroid cancer in celiac disease.
abstract: Patients with celiac disease have an increased rate of malignancies that are not limited to lymphomas. Thyroid carcinoma has not previously been associated with celiac disease. However, among a cohort of patients with celiac disease, we identified an increased risk of papillary carcinoma of the thyroid, standard morbidity ratio of 22.52 (95% confidence interval 14.90-34.04; P < .001), compared to United States national surveillance data. These patients were on a gluten-free diet. Only 1 had Hashimoto's thyroiditis, suggesting that mechanisms apart from autoimmune thyroiditis contribute to the increased risk of carcinoma of the thyroid in celiac disease.
authors.affiliation: Department of Medicine, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, Room 645, New York, 10032 New York, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Kent
authors.forename: Russell
authors.initials: R
authors.lastname: McBride
authors.forename: Robert
authors.initials: R
authors.lastname: McConnell
authors.forename: Alfred I
authors.initials: AI
authors.lastname: Neugut
authors.forename: Govind
authors.initials: G
authors.lastname: Bhagat
authors.forename: Peter H R
authors.initials: PH
authors.lastname: Green
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000453:epidemiology*; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment; D018426:SEER Program; D013964:Thyroid Neoplasms / Q000453:epidemiology*; D013997:Time Factors; D014481:United States / Q000453:epidemiology