Plasma cell dyscrasia with kappa light-chain crystals in proximal tubular cells: a histological, immunofluorescent, and ultrastructural study.
This is a case report of a 56-year-old man with plasma cell dyscrasia who presented with proximal tubulopathy manifested as kappa light-chain crystal deposition in the proximal convoluted tubular cells. This was associated with mild cellular damage. The crystals were seen as negative images with the hematoxylin-eosin and periodic acid-Schiff (PAS) stains. They were identified as kappa light-chains by immunofluorescent imaging and confirmed by immunoelectron microscopy. Ultrastructurally, the crystals appear to be located within lysosomes. No deposits of light-chains were seen elsewhere in the kidney biopsy.
Cai
Guoping
G
Department of Pathology, New York University Medical Center, New York, New York, USA.
Sidhu
Gurdip S
GS
Wieczorek
Rosemary
R
Gu
Xin
X
Herrera
Guillermo A
GA
Cubukcu-Dimopulo
Olcay
O
Kahn
Thomas
T
D003460:Crystallization; D005455:Fluorescent Antibody Technique; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000737:chemistry / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D010265:Paraproteinemias / Q000378:metabolism* / Q000473:pathology*
D007145:Immunoglobulin kappa-Chains