Changes of brain activity in the aged SAMP mouse.
This study investigates characteristics of aging in the central nervous system of the senescence accelerated prone mice (SAMP8). We examined 3 and 10-months old senescence-accelerated-prone mice (SAMP8) for functional and molecular changes in their brains, specifically in the hippocampus and somatosensory cortex. There was no statistically significant increase in the apoptosis indicators as revealed by Western Blotting for BAD and TUNEL experiments. However, the functional magnetic resonance imaging showed an increase in the area of BOLD images from the 3-month old to the 10-months old SAMP mice upon the application of tail stimulus. These results demonstrated a lack of neuronal deaths but an increase in the activated brain area with age.
Zhang
Lihong
L
Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Li
Qi
Q
Wolff
Lucille T
LT
Antonio
Gregory E
GE
Yeung
David K W
DK
Zhang
Aiqun
A
Wu
Yan
Y
Yew
David T
DT
D000375:Aging / Q000502:physiology*; D000818:Animals; D017209:Apoptosis; D015153:Blotting, Western; D001931:Brain Mapping / Q000379:methods; D016922:Cellular Senescence; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D020287:In Situ Nick-End Labeling; D008279:Magnetic Resonance Imaging; D051379:Mice; D008806:Mice, Inbred AKR; D023421:Models, Animal; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*; D051025:bcl-Associated Death Protein / Q000378:metabolism
C494820:Bad protein, mouse; D051025:bcl-Associated Death Protein