Tissue distribution of blood group membrane proteins beyond red cells: evidence from cDNA libraries.
The proteins of blood group systems are expressed on red blood cells (RBC) by definition. We searched nucleotide databases of human expressed sequence tags (EST) to collate the distribution of 22 distinct membrane proteins in cells and tissues other than RBC. The documented blood group genes are: MNS, Rh, Lutheran, Kell, Duffy, Kidd, Diego, Yt, Xg, Scianna, Dombrock, Colton, Landsteiner-Wiener, Kx, Gerbich, Cromer, Knops, Indian, Ok, Raph, John-Milton-Hagen and Gill. The genes were grouped according to their overall and their relative expression in embryo and adults. We describe the distribution of EST in cells, tissues and cell lines with a focus on non-RBC tissues.
Rojewski
Markus T
MT
Department of Transfusion Medicine, University Hospital, Ulm, Germany.
Schrezenmeier
Hubert
H
Flegel
Willy A
WA
D000017:ABO Blood-Group System / Q000235:genetics*; D001787:Blood Group Incompatibility / Q000235:genetics*; D002460:Cell Line; D018076:DNA, Complementary / Q000235:genetics*; D004912:Erythrocytes / Q000502:physiology*; D020224:Expressed Sequence Tags; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009928:Organ Specificity / Q000235:genetics
D000017:ABO Blood-Group System; D018076:DNA, Complementary; D008565:Membrane Proteins