title: Photoisomerization as a modulator of the DNA-cleaving efficiency of novel azo bispropargyl sulfones.
abstract: Novel azobenzene based bispropargyl sulfones have been prepared in the thermally stable E-form: irradiation with a high-pressure Hg lamp converted them to the Z-isomer which showed higher DNA-cleaving efficiency.
authors.affiliation: Bioorganic Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, India.
authors.forename: Moumita
authors.initials: M
authors.lastname: Kar
authors.forename: Amit
authors.initials: A
authors.lastname: Basak
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D007536:Isomerism; D008956:Models, Chemical; D010293:Pargyline / Q000031:analogs & derivatives*; D010777:Photochemistry / Q000379:methods*; D013450:Sulfones / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D013450:Sulfones; D004247:DNA; D010293:Pargyline