Biodosimetry using chromosome aberrations in human lymphocytes.
In vitro dose-response calibration curves for (60)Co gamma rays have been established for unstable chromosome aberrations in human peripheral blood lymphocytes. The observed dose-response data were fitted to a linear quadratic model. The calibration curve parameters were used to estimate the equivalent whole-body dose and dose to the irradiated region in partial body irradiation of cancer patients. The derived partial body doses and fractions of lymphocytes irradiated were in agreement with those estimated from the radiotherapy regimes.
Senthamizhchelvan
S
S
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India.
Pant
G S
GS
Rath
G K
GK
Julka
P K
PK
Nair
O
O
Joshi
R C
RC
Malhotra
A
A
Pandey
R M
RM
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D020732:Cytogenetic Analysis / Q000379:methods; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics* / Q000532:radiotherapy*; D011834:Radiation Monitoring; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes