title: Magnetic resonance mammography in the evaluation of recurrence at the prior lumpectomy site after conservative surgery and radiotherapy.
abstract: BACKGROUND
  The aim was to assess the value of magnetic resonance mammography (MRM) in the detection of recurrent breast cancer on the prior lumpectomy site in patients with previous conservative surgery and radiotherapy.
  
  
  METHODS
  Between April 1999 and July 2003, 93 consecutive patients with breast cancer treated with conservative surgery and radiotherapy underwent MRM, when a malignant lesion on the site of lumpectomy was suspected by ultrasound and/or mammography. MRM scans were evaluated by morphological and dynamic characteristics. MRM diagnosis was compared with histology or with a 36-month imaging follow-up. Enhancing areas independent of the prior lumpectomy site, incidentally detected during the MRM, were also evaluated.
  
  
  RESULTS
  MRM findings were compared with histology in 29 patients and with a 36-month follow-up in 64 patients. MRM showed 90% sensitivity, 91.6% specificity, 56.3% positive predictive value and 98.7% negative predictive value for detection of recurrence on the surgical scar. MRM detected 13 lesions remote from the scar. The overall sensitivity, specificity, positive predictive value and negative predictive value of MRM for detection of breast malignancy were 93.8%, 90%, 62.5% and 98.8%, respectively.
  
  
  CONCLUSIONS
  MRM is a sensitive method to differentiate recurrence from post-treatment changes at the prior lumpectomy site after conservative surgery and radiation therapy. The high negative predictive value of this technique can avoid unnecessary biopsies or surgical treatments.
authors.affiliation: Department of Radiology, European Institute of Oncology IRCCS, 435 Via Ripamonti, 20141 Milan, Italy. lorenzo.preda@ieo.it
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Preda
authors.forename: Gaetano
authors.initials: G
authors.lastname: Villa
authors.forename: Stefania
authors.initials: S
authors.lastname: Rizzo
authors.forename: Luca
authors.initials: L
authors.lastname: Bazzi
authors.forename: Daniela
authors.initials: D
authors.lastname: Origgi
authors.forename: Enrico
authors.initials: E
authors.lastname: Cassano
authors.forename: Massimo
authors.initials: M
authors.lastname: Bellomi
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy; D002921:Cicatrix / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D015412:Mastectomy, Segmental / Q000009:adverse effects*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000209:etiology; D011237:Predictive Value of Tests; D011878:Radiotherapy / Q000009:adverse effects*