[Multiple post-chemotherapy plantar nevi].
The induction of multiple melanocytic nevi in children after chemotherapy has been documented in the literature. This situation apparently has more to do with the state of immunosuppression that is produced than with any specific agent used. We present the case of a 12-year-old girl who presented with multiple plantar melanocytic nevi after multidrug chemotherapy for acute lymphocytic leukemia. None of the lesions showed any alarming clinical signs. Although the degeneration of post-chemotherapy melanocytic nevi to melanoma has not been documented in any of the cases described, the presence of a high number of melanocytic nevi is an accepted risk factor for melanoma; thus, close clinical follow-up of these patients seems advisable.
Hueso
Luis
L
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España. luishueso@msn.com
Requena
Celia
C
Serra-Guillén
Carlos
C
Alfaro
Alberto
A
Nagore
Eduardo
E
Llombart
Beatriz
B
Botella-Estrada
Rafael
R
Sanmartín
Onofre
O
Guillén
Carlos
C
D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D005534:Foot Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D009508:Nevus, Pigmented / Q000139:chemically induced* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
D000970:Antineoplastic Agents