title: Giant cell reparative granuloma of the sphenoid bone.
abstract: We present 2 patients with giant cell reparative granuloma (GCRG) of the sphenoid bone. The first patient is an 8-year-old boy with involvement of the greater wing, and the second is a 53- year-old man with a lateral pterygoid plate mass. Both patients presented with rapid expansion of lytic bone lesions, which had solid and cystic components and lacked matrix calcification. Biopsies were indeterminate for definitive diagnoses. The radiologic appearance, location, and incidence of the lesions, and the patient's age and medical history are helpful aids in narrowing the differential diagnosis of sphenoid bone lesions. However, the imaging and, occasionally, even the histologic findings may not suggest the specific diagnosis of GCRG, which must be added into the differential diagnosis of rapidly enlarging cystic bone lesions of the sphenoid bone.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA. aysearalasmak@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Aralasmak
authors.forename: N
authors.initials: N
authors.lastname: Aygun
authors.forename: W H
authors.initials: WH
authors.lastname: Westra
authors.forename: D M
authors.initials: DM
authors.lastname: Yousem
mesh_terms: D001706:Biopsy; D001845:Bone Cysts / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002648:Child; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006101:Granuloma, Giant Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis; D013100:Sphenoid Bone / Q000473:pathology* / Q000601:surgery; D025321:Surgery, Computer-Assisted; D014057:Tomography, X-Ray Computed