Asymmetric cerebral lesion pattern in X-linked adrenoleukodystrophy.
X-linked adrenoleukodystrophy (X-ALD) is an inherited disease caused by peroxisomal dysfunction. X-ALD usually involves the cerebral white matter in an approximately symmetric way. We report a 10-year-old boy with the cerebral form of X-ALD who presented with cognitive impairment and left spastic hemiparesis. Brain magnetic resonance imaging (MRI) showed asymmetric lesions, and the lesions in the right hemisphere were predominant. In the late stage of the disease, bilateral limbs were involved. The cerebral lesions enlarged and appeared approximately symmetric on MRI. The purpose of our report is to highlight asymmetric demyelination in initial presentation of X-ALD.
Wang
Shuang
S
Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, China. freud_wang@hotmail.com
Wu
Ji-Min
JM
Cheng
Yuan-Shen
YS
D000326:Adrenoleukodystrophy / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male