title: Mutant p53 gain of function: the NF-Y connection.
abstract: The molecular mechanisms underlying mutant p53 gain of function are becoming increasingly complex. In this issue of Cancer Cell, Di Agostino et al. identify the heterotrimeric transcription factor NF-Y as an interacting partner of mutant p53. They show that mutant p53/NF-Y complexes bind to NF-Y target promoters and recruit p300 in response to DNA damage, resulting in aberrant transactivation of NF-Y target genes and cell cycle deregulation. These data thereby implicate transcriptional activation by mutant p53 as a key mechanism responsible for its oncogenic activity.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Peart
authors.forename: Carol
authors.initials: C
authors.lastname: Prives
mesh_terms: D023081:CCAAT-Binding Factor / Q000378:metabolism*; D006801:Humans; D009154:Mutation / Q000235:genetics; D011485:Protein Binding; D014158:Transcription, Genetic / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D023081:CCAAT-Binding Factor; D016159:Tumor Suppressor Protein p53