title: Endothelial lipase is associated with inflammation in humans.
abstract: The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men. Plasma C-reactive protein (CRP) concentrations were measured with a highly sensitive commercial immunoassay, plasma interleukin-6 (IL-6) concentrations were measured using a commercial ELISA, and plasma secretory phospholipase A(2) type IIA (sPLA(2)-IIA) concentrations were measured using a commercial assay in a sample of 74 moderately obese men (mean body mass index, 29.8 +/- 5.2 kg/m(2)). Plasma EL concentrations were positively correlated with various indices of obesity, fasting plasma insulin, and plasma CRP, IL-6, and sPLA(2)-IIA concentrations. Multiple regression analyses revealed that plasma CRP concentrations explained 14.5% (P = 0.0008) of the variance in EL concentrations. When entered into the model, LPL activity accounted for 16.1% (P < 0.0001) and plasma CRP concentrations accounted for 20.9% (P < 0.0001) of the variance in EL concentrations. The combined impact of visceral adipose tissue (VAT) and of an inflammation score on EL concentrations was investigated. Among subjects with high or low VAT, those having a high inflammation score based on plasma CRP, IL-6, and sPLA(2)-IIA concentrations had increased plasma EL concentrations (P = 0.0005). In conclusion, our data reveal a strong association between proinflammatory cytokines and plasma EL concentrations among healthy people with low or high VAT levels.
authors.affiliation: Institute on Nutraceuticals and Functional Foods, Laval University, Québec, Canada.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Paradis
authors.forename: Karen O
authors.initials: KO
authors.lastname: Badellino
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rader
authors.forename: Yves
authors.initials: Y
authors.lastname: Deshaies
authors.forename: Patrick
authors.initials: P
authors.lastname: Couture
authors.forename: Wiedad R
authors.initials: WR
authors.lastname: Archer
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bergeron
authors.forename: Benoît
authors.initials: B
authors.lastname: Lamarche
mesh_terms: D050154:Adiposity; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D054501:Group II Phospholipases A2; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D015850:Interleukin-6 / Q000097:blood; D050152:Intra-Abdominal Fat / Q000473:pathology; D008049:Lipase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein; C410382:LIPG protein, human; D008049:Lipase; D010741:Phospholipases A; D054501:Group II Phospholipases A2