Accelerated acquisition of permeability barrier function in the skin of presenilin-1-deficient embryos.
Presenilin-1 (PS1) is a transmembrane protein and is responsible for the development of early-onset familial Alzheimer's disease. PS1 is essential for neurogenesis, somitogenesis, angiogenesis and cardiac morphogenesis. We report here that PS1 is involved in the development of skin barrier function. PS1-deficient embryos showed an accelerated acquisition of permeability barrier function at embryonic day 17.5 as manifested by the exclusion of a dye solution. While the expression of beta-catenin and epidermal differentiation markers such as keratin 1 and loricrin was not substantially altered, an increased accumulation of E-cadherin was observed immunohistochemically in the mutant skin. These results suggest that PS1 regulates the acquisition of permeability barrier function in the skin.
Nakajima
Mitsunari
M
Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan.
Ogawa
Minetaro
M
Shimoda
Yuri
Y
Koseki
Haruhiko
H
Shirasawa
Takuji
T
Furukawa
Kiyoshi
K
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D007365:Intercellular Junctions / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010539:Permeability; D053764:Presenilin-1 / Q000235:genetics / Q000502:physiology*; D012867:Skin / Q000166:cytology / Q000196:embryology*; D012879:Skin Physiological Phenomena / Q000235:genetics*; D051176:beta Catenin / Q000378:metabolism
D015820:Cadherins; D053764:Presenilin-1; D051176:beta Catenin