Double trouble (McArdle's disease and myasthenia gravis): how can exercise help?
We report a 29-year-old patient with McArdle's disease and myasthenia gravis. She had been debilitated with McArdle's disease since childhood (with marked rhabdomyolysis) and was obese. Myasthenia gravis was diagnosed at 24 years of age. After 3 months of aerobic exercise training, her exercise capacity increased significantly and she regained the ability to live independently. We conclude that even patients with profound neuromuscular diseases may benefit from carefully prescribed exercise training.
Lucia
Alejandro
A
Universidad Europea de Madrid, 28670 Madrid, Spain. alejandro.lucia@uem.es
Maté-Muñoz
José L
JL
Pérez
Margarita
M
Foster
Carl
C
Gutiérrez-Rivas
Eduardo
E
Arenas
Joaquín
J
D000328:Adult; D049108:Cell Enlargement; D003402:Creatine Kinase / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D024982:Glycogen Phosphorylase, Muscle Form / Q000172:deficiency; D006012:Glycogen Storage Disease Type V / Q000150:complications* / Q000503:physiopathology / Q000534:rehabilitation*; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000378:metabolism; D018482:Muscle, Skeletal / Q000294:innervation / Q000378:metabolism / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000150:complications* / Q000503:physiopathology / Q000534:rehabilitation*; D009469:Neuromuscular Junction / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology; D016896:Treatment Outcome
D019344:Lactic Acid; D024982:Glycogen Phosphorylase, Muscle Form; D003402:Creatine Kinase