Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms.
BACKGROUND
Cutaneous leiomyomas and leiomyosarcomas are rare tumors that originate from the arrector muscle of hair follicles or the smooth muscle of blood vessels.


METHODS
A 74-year-old male presented with a single, erythematous nodule on the left upper arm. This lesion developed within the excision scar of a piloleiomyoma that had been excised 3 years ago. Additionally, physical examination revealed a tender nodule on the right ear.


RESULTS
Histological examination showed a cutaneous leiomyosarcoma with myxoid alteration on the upper arm and an angioleiomyoma on the right ear.


CONCLUSIONS
Myxoid leiomyosarcomas have exclusively been reported in the uterus and gastrointestinal tract, but not in the skin. Here, we describe a case of cutaneous leiomyosarcoma with myxoid alteration that developed in the excision scar of a piloleiomyoma and was accompanied by a cutaneous angioleiomyoma in a different location.
Utikal
Jochen
J
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany. jochen.utikal@haut.ma.uni-heidelberg.de
Haus
Georg
G
Poenitz
Nina
N
Koenen
Wolfgang
W
Back
Walter
W
Dippel
Edgar
E
Gratchev
Alexei
A
Goerdt
Sergij
S
D000368:Aged; D018229:Angiomyoma / Q000473:pathology* / Q000601:surgery; D002921:Cicatrix / Q000473:pathology; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D018235:Smooth Muscle Tumor / Q000473:pathology*