title: New onset diabetes mellitus incidence and risk factors in kidney transplantation: results of the observational cross-sectional study diapason.
abstract: BACKGROUND
  New-onset diabetes mellitus (NODM) is a frequent complication of kidney transplantation. Data on NODM are mainly available in the United States. A study was implemented in a French population of kidney transplants. The incidence and risk factors of NODM were analysed. Diabetes was defined according to American Diabetes/World Health Organization guidelines.
  
  
  METHODS
  Diapason is an observational cross-sectional study of 527 kidney transplant patients from 17 units based on data collected at a single routine visit 6 to 24 months after kidney transplantation.
  
  
  RESULTS
  The mean age of the patients was 47.2 years, and 61.1% were men; 49.5% were receiving cyclosporine microemulsion and 50.5% tacrolimus. NODM developed in 7.0% after a median interval of 1.6 months. Univariate analysis identified six pretransplantation risk factors: advanced age, impaired fasting glucose, at least two cardiovascular risk factors, hepatitis C status, maximums lifetime body mass index above 25, and tacrolimus or cyclosporine therapy. Four independent factors were identified by multivariate analysis: body mass index above 25 (OR = 5.1), pretransplantation impaired fasting glucose (OR = 4.7), hepatitis C status (OR = 4.7), and tacrolimus versus cyclosporine treatment (OR = 3.0).
  
  
  CONCLUSIONS
  NODM is associated with risk factors present prior to kidney transplantation and with treatment with tacrolimus as opposed to cyclosporine. Therefore, the choice of calcineurin inhibitor should be based on the patient's overall risk profile.
authors.affiliation: Department of Nephrology, Dialysis and Transplantation, CHU Rangueil, 1 avenue Jean Poulhès, TSA 50032, 31059 Toulouse cedex 9, France. kamar.n@chu-toulouse.fr
authors.forename: N
authors.initials: N
authors.lastname: Kamar
authors.forename: C
authors.initials: C
authors.lastname: Mariat
authors.forename: M
authors.initials: M
authors.lastname: Delahousse
authors.forename: N
authors.initials: N
authors.lastname: Lefrançois
authors.forename: J
authors.initials: J
authors.lastname: Dantal
authors.forename: P
authors.initials: P
authors.lastname: Benhamou
mesh_terms: D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000601:surgery*; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects / Q000706:statistics & numerical data*; D016896:Treatment Outcome