The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
The American Cancer Society estimates 30,180 new cases of thyroid cancer in the United States in 2006. Of all thyroid cancers, 15-20% are follicular thyroid carcinoma (FTC), making this the second most common thyroid malignancy (after papillary carcinoma). A proportion of FTC has been found to be associated with a chromosomal translocation, t (2, 3)(q13;p25), which fuses the thyroid-specific transcription factor paired box-8 with the peroxisome proliferator-activated receptor-gamma nuclear receptor, a ubiquitously expressed transcription factor. This fusion event causes expression of a paired box-8/peroxisome proliferator-activated receptor-gamma fusion protein (PPFP). PPFP is detected in approximately 30% of FTC. In this report we review data on the role of PPFP in FTC, its mechanism of oncogenesis, and PPFP targeting as a strategy in thyroid cancer treatment.
Reddi
Honey V
HV
Department of Medicine/Division of Endocrinology, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA.
McIver
Bryan
B
Grebe
Stefan K G
SK
Eberhardt
Norman L
NL
D018265:Carcinoma, Papillary, Follicular / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D006801:Humans; D008954:Models, Biological; D015514:Oncogene Proteins, Fusion / Q000502:physiology*; D000072636:PAX8 Transcription Factor; D047495:PPAR gamma / Q000235:genetics / Q000502:physiology*; D051761:Paired Box Transcription Factors / Q000235:genetics / Q000502:physiology*; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000235:genetics / Q000628:therapy
D015514:Oncogene Proteins, Fusion; D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D047495:PPAR gamma; D051761:Paired Box Transcription Factors