A convenient preparation of (1R,2S,7S,8R)-3,5-diaza-2,7-dimethyl-1,8-diphenyloctan-1,8-diol and its enantiomer.
The synthesis of (1R,2S,7S,8R)-3,5-diaza-2,7-dimethyl-1,8-diphenyloctan-1,8-diol 6 and its enantiomer 7 are described utilising (-)-(1R,2S)- or (+)-(1S,2R)-norephedrine, respectively.
Murphy
Patrick Joseph
PJ
School of Chemistry, University of Wales, Bangor, Gwynedd, LL57 2UW, UK. paddy@bangor.ac.uk
Pinato
Samuela
S
Thomas
Dafydd
D
Oller-Lopez
Juan Luis
JL
D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010665:Phenylpropanolamine / Q000737:chemistry*; D013237:Stereoisomerism
C514037:(1R,2S,7S,8R)-3,5-diaza-2,7-dimethyl-1,8-diphenyloctan-1,8-diol; D000605:Amino Alcohols; D010665:Phenylpropanolamine