title: Longitudinal changes of cerebral glucose metabolism in semantic dementia.
abstract: BACKGROUND
  Semantic dementia (SD).
  
  
  OBJECTIVE
  To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET).
  
  
  METHODS
  Eight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average 15 months later.
  
  
  RESULTS
  Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05).
  
  
  CONCLUSIONS
  Subtle functional changes suffice to produce significant neuropsycho- logical deterioration.
authors.affiliation: Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany. janine.diehl@lrz.tum.de
authors.forename: J
authors.initials: J
authors.lastname: Diehl-Schmid
authors.forename: T
authors.initials: T
authors.lastname: Grimmer
authors.forename: A
authors.initials: A
authors.lastname: Drzezga
authors.forename: S
authors.initials: S
authors.lastname: Bornschein
authors.forename: R
authors.initials: R
authors.lastname: Perneczky
authors.forename: H
authors.initials: H
authors.lastname: Forstl
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
authors.forename: A
authors.initials: A
authors.lastname: Kurz
mesh_terms: D017668:Age of Onset; D001923:Brain Chemistry / Q000502:physiology*; D003704:Dementia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012660:Semantics
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose