Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents.
A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown > 94% inhibition against promastigotes at a concentration of 10 microg/mL.
Sunduru
Naresh
N
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Agarwal
Anu
A
Katiyar
Sanjay Babu
SB
Nishi
Goyal
Neena
N
Gupta
Suman
S
Chauhan
Prem M S
PM
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000138:chemical synthesis*
D006571:Heterocyclic Compounds; D011743:Pyrimidines; D014227:Triazines; D014344:Trypanocidal Agents