Adenovirus subversion of immune surveillance, apoptotic and growth regulatory pathways: a model for tumorigenesis.
The adenovirus system provides a novel model for evaluating the roles of multiple factors involved in tumour progression. In common with other DNA tumour viruses, adenovirus employs a variety of strategies to evade immune surveillance and perturbs cellular apoptotic and growth regulatory pathways to ensure efficient replication of progeny virions. Such subversion of cellular networks is also found in tumour cells. The mechanism behind the avoidance of immune surveillance and the extent of cellular network interference achieved by adenovirus is still being uncovered and is predicted to have ramifications for the design of cancer therapeutics.
Strath
Janet
J
Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
Blair
G E
GE
D000256:Adenoviridae / Q000276:immunology*; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001483:Base Sequence; D004263:DNA Tumor Viruses / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000276:immunology* / Q000821:virology*