[Clinical observation on shufei granule in improving right ventricular function of patients with chronic pulmonary heart disease].
OBJECTIVE
To observe the effect of Shufei Granule (SG) on right ventricular function in patients with chronic pulmonary heart disease (CPHD).


METHODS
One hundred CPHD patients were randomly divided into two groups, the control group (n = 40) treated with fleroxacin 0.2 g twice per day by intravenous dripping and diprophylline 0.2 g 3 times per day orally, the treatment group (n = 60) treated with SG 10 g 3 times a day orally additionally besides the treatment given to the control group. The therapeutic course for both groups was 3 weeks. The changes of the cardiac function, the right ventricular function [A peak velocity (VA), E peak velocity (VE), VA/VE, systolic pulmonary artery pressure (SPAP), pre-ejection period (PEP), right ventricular ejection time (RVET), PEP/RVET], and blood-gas analysis were investigated, the condition of clinical symptoms and signs as well as tongue pictures were observed also.


RESULTS
The total effective rate was 91.6% in the treated group, significantly higher than that in the control group (70.0%, P < 0.01); the improvements in symptom score, cardiac function and the other laboratory indexes were all superior in the treatment group to those in the control group (P < 0.05, P < 0.01).


CONCLUSIONS
SG is an effective drug for improving right ventricular function in CPHD patients.
Li
Ping
P
Tai'an Hospital of Traditional Chinese Medicine, Shandong 271000.
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004400:Dyphylline / Q000627:therapeutic use; D005260:Female; D016576:Fleroxacin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011660:Pulmonary Heart Disease / Q000188:drug therapy* / Q000503:physiopathology; D016278:Ventricular Function, Right / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D004400:Dyphylline; D016576:Fleroxacin