title: Source analysis of epileptic discharges using multiple signal classification analysis.
abstract: Multiple signal classification is an alternative to the traditional dipole fitting source analysis methods. Our aim was to assess the clinical usefulness of this algorithm and to compare the localization of the epileptiform electroencephalography discharges with the regions of altered cerebral blood flow in 10 patients with complex partial seizures undergoing preoperative investigation. We performed multiple signal classification analysis of ictal and interictal discharges, and registered single-photon emission computed tomography. Localization of the ictal, but not the interictal discharges, as determined by multiple signal classification analysis was consistent with the regions showing perfusion changes on the single-photon emission computed tomography. Multiple signal classification analysis is a promising tool in localizing foci in patients with complex partial seizures and may contribute to the preoperative evaluation.
authors.affiliation: Department of Clinical Neurophysiology, Department of Neurology, Copenhagen University, Glostrup Hospital, Glostrup, Denmark.
authors.forename: Sándor
authors.initials: S
authors.lastname: Beniczky
authors.forename: Peter S
authors.initials: PS
authors.lastname: Oturai
authors.forename: Jørgen
authors.initials: J
authors.lastname: Alving
authors.forename: Anne
authors.initials: A
authors.lastname: Sabers
authors.forename: Margrethe
authors.initials: M
authors.lastname: Herning
authors.forename: Martin
authors.initials: M
authors.lastname: Fabricius
mesh_terms: D000328:Adult; D000465:Algorithms; D001931:Brain Mapping; D004569:Electroencephalography / Q000379:methods; D017029:Epilepsy, Complex Partial / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012815:Signal Processing, Computer-Assisted; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods