title: Comparison of enhancement, image quality, cost, and adverse reactions using 2 different contrast medium concentrations for routine chest CT on 16-slice MDCT.
abstract: OBJECTIVE
  To evaluate the degree of enhancement and image quality of chest computed tomographic (CT) examinations on 16-slice multidetector CT using low-concentration [300 milligrams of iodine per milliliter (mg I/mL)] and high-concentration (370 mg I/mL) contrast media; to assess the impact on cost and adverse reactions of the use of high-iodine concentration contrast medium.
  
  
  METHODS
  A total of 100 patients scheduled for routine chest CT examinations were administered nonionic contrast medium of 2 strengths: low-iodine concentration contrast medium (300 mg I/mL) [group A: n = 50; male-female ratio, 28:22; mean age, 58.4 years] and high-iodine concentration contrast medium (370 mg I/mL) (group B: n = 50; male-female ratio, 18:32; mean age, 57.6 years) with a constant amount of iodine (400 mg) injected per kilogram of body weight. Contrast media were injected using a dual injector at 2.5 mL/s followed by a 30-mL saline at 2.5 mL/s. The degree of enhancement was quantified by measuring Hounsfield unit values in different arteries and veins and was also rated on a 5-point scale for qualitative assessment. We also evaluated perivenous contrast-related artifacts. The data were compared using Mann-Whitney U test for both qualitative and quantitative enhancement ratings. A value of less than 0.05 was considered statistically significant. The value was adjusted using Bonferroni correction for statistical significance when multiple comparisons were performed. The difference in cost and the incidence of adverse reactions in both groups were calculated.
  
  
  RESULTS
  The mean enhancement values in group B were significantly greater (P < 0.05) than those in group A. The mean Hounsfield units and standard deviation in groups A and B were aorta = 153 +/- 4, 216 +/- 20; pulmonary artery = 147 +/- 10, 208 +/- 20; superior vena cava = 155 +/- 27, 299 +/- 72; and pulmonary vein = 134 +/- 10, 215 +/- 30, respectively. The mean enhancement on a 5-point scale was greater in group B (4.2) than in group A (3.3) (P < 0.01). No significant difference between groups in perivenous artifacts was seen. Up to 5.5% savings in cost resulted from the use of a higher concentration of iodine, with no increase in adverse reactions.
  
  
  CONCLUSIONS
  Use of higher-concentration contrast media provides a higher degree of contrast enhancement and image quality for a routine chest CT on a 16-slice multidetector CT. It also contributes to considerable cost savings with no increased risk of adverse reactions compared with low-concentration contrast media.
authors.affiliation: Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Bindu N
authors.initials: BN
authors.lastname: Setty
authors.forename: Dushyant V
authors.initials: DV
authors.lastname: Sahani
authors.forename: Kathy
authors.initials: K
authors.lastname: Ouellette-Piazzo
authors.forename: Peter F
authors.initials: PF
authors.lastname: Hahn
authors.forename: Jo-Anne O
authors.initials: JA
authors.lastname: Shepard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001027:Aortography / Q000379:methods; D016477:Artifacts; D003287:Contrast Media / Q000009:adverse effects* / Q000191:economics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007479:Iopamidol / Q000009:adverse effects / Q000191:economics; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011667:Pulmonary Veins / Q000000981:diagnostic imaging; D011856:Radiographic Image Enhancement / Q000379:methods*; D013902:Radiography, Thoracic / Q000379:methods*; D012965:Sodium Chloride / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014683:Vena Cava, Superior / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media; D012965:Sodium Chloride; D007479:Iopamidol