title: Michael addition of pyrimidine with disaccharide acrylates catalyzed in organic medium with lipase M from Mucor javanicus.
abstract: The Michael addition of fluorouracil (0.01 mol), uracil (0.01 mol), thymine (0.01 mol) to disaccharide acrylates (0.03 mol) was carried out in pyridine (20 ml) at 50 degrees C for 72 h with lipase M from Mucor javanicus (200 mg). Six new pyrimidine derivatives containing a branched sugar were obtained in yields from 56 to 75%.
authors.affiliation: Department of Environment Engineering, Daqing Petroleum Institute, Daqing 163318, People's Republic of China. hongxiadai@163.com
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Dai
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Yao
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D004187:Disaccharides / Q000737:chemistry*; D005472:Fluorouracil / Q000737:chemistry*; D008049:Lipase / Q000378:metabolism*; D009089:Mucor / Q000201:enzymology; D013941:Thymine / Q000737:chemistry; D014498:Uracil / Q000737:chemistry
chemical_list: D000179:Acrylates; D004187:Disaccharides; D014498:Uracil; D008049:Lipase; D013941:Thymine; D005472:Fluorouracil