Myxoid lipoadenoma of parathyroid gland: a case report and literature review.
Myxoid lipoadenoma of the parathyroid gland is a rare variant of parathyroid adenoma. We present the case of a 40-year-old man with asymptomatic hypercalcemia who underwent surgical removal of a parathyroid adenoma. Histologically, the tumor consisted of monomorphous round-to-oval chief cells arranged in several architectural patterns including solid sheet-like, trabecular, and follicular. The tumor stroma was prominently myxoid with interspersed mature adipose tissue. Immunohistochemistry confirmed expression of thyroid transcription factor and parathyroid hormone by all tumor cells and a low proliferation rate with a Ki-67 labeling index of at most 5%. Although the lesion exhibited characteristics that have been previously associated with "atypical parathyroid adenoma," such as dense fibrous bands within the tumor and a trabecular growth pattern, there was no further evidence, neither histologically nor clinically, for malignant behavior of the tumor.
Fischer
Ingeborg
I
Department of Pathology, New York University School of Medicine and NYU Cancer Institute, New York Harbor Healthcare System, New York, NY 10010, USA.
Wieczorek
Rosemary
R
Sidhu
Gurdip S
GS
Pei
Zhiheng
Z
West
Brian
B
Lee
Peng
P
D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D049109:Cell Proliferation; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008067:Lipoma / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D010282:Parathyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology