Analysis of antioxidant activities contained in the Boesenbergia pandurata Schult. Rhizome.
The rhizome of Boesenbergia pandurata Schult. was found to possess potent antioxidant activity in a rat brain homogenate model. Bioassay-guided isolation of the active compounds from a CH2Cl2-MeOH (1:1) extract led to the isolation of 5-hydroxy-7-methoxyflavanone, panduratin A, 5,7-dihydroxyflavanone, 2',6'-dihydroxy-4'-methoxychalcone, 2',4'-dihydroxy-6'-methoxychalcone, and 4-hydroxypanduratin A. Panduratin A, 4-hydroxypanduratin A, and 2',6'-dihydroxy-4'-methoxychalcone were also found to exert neuroprotective effects.
Shindo
Kazutoshi
K
Department of Food and Nutrition, Japan Women's University, Tokyo, Japan. kshindo@fc.jwu.ac.jp
Kato
Miki
M
Kinoshita
Asuka
A
Kobayashi
Asami
A
Koike
Yukiko
Y
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D047188:Chalcones / Q000302:isolation & purification* / Q000494:pharmacology; D044950:Flavanones / Q000302:isolation & purification* / Q000494:pharmacology; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D027343:Rhizome / Q000737:chemistry / Q000378:metabolism; D030521:Zingiberaceae / Q000737:chemistry / Q000378:metabolism*
D000975:Antioxidants; D047188:Chalcones; D044950:Flavanones; D008054:Lipid Peroxides