Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis.
The application of parallel synthesis to lead optimization programs in drug discovery has been an ongoing challenge since the first reports of library synthesis. A number of approaches to the application of parallel array synthesis to lead optimization have been attempted over the years, ranging from widespread deployment by (and support of) individual medicinal chemists to centralization as a service by an expert core team. This manuscript describes our experience with the latter approach, which was undertaken as part of a larger initiative to optimize drug discovery. In particular, we highlight how concepts taken from the manufacturing sector can be applied to drug discovery and parallel synthesis to improve the timeliness and thus the impact of arrays on drug discovery.
Weller
Harold N
HN
The Bristol-Myers Squibb Pharmaceutical Research Institute, Route 206 and Provinceline Road, Princeton, New Jersey 08543, USA. Harold.Weller@bms.com
Nirschl
David S
DS
Petrillo
Edward W
EW
Poss
Michael A
MA
Andres
Charles J
CJ
Cavallaro
Cullen L
CL
Echols
Martin M
MM
Grant-Young
Katherine A
KA
Houston
John G
JG
Miller
Arthur V
AV
Swann
R Thomas
RT
D020650:Combinatorial Chemistry Techniques; D015195:Drug Design