title: Regression of nodular liver lesions in Wilson's disease.
abstract: Long-term follow-up abdominal imaging studies have not been reported previously in patients with the hepatic form of Wilson's disease (WD). This paper reports the case of a 35-year-old woman with symptoms dating back several months and with multiple, nodular liver lesions. The lesions were hyperdense on non-enhanced computed tomography and hypointense on T2-weighted magnetic resonance (MR) images. A diagnosis of WD was established several weeks after her admission to hospital, and chelating treatment was commenced promptly. No abnormalities were found on follow-up MR examinations of the abdomen and brain 4.5 years later. These imaging features suggest that so long as WD is diagnosed in the initial stages, liver nodules can regress with time and complete healing can be achieved with continuous decoppering treatment.
authors.affiliation: Department of Radiology, Institute of Oncology, Sremska Kamenica, Serbia.
authors.forename: D
authors.initials: D
authors.lastname: Kozic
authors.forename: M
authors.initials: M
authors.lastname: Svetel
authors.forename: I
authors.initials: I
authors.lastname: Petrovic
authors.forename: R N
authors.initials: RN
authors.lastname: Sener
authors.forename: V S
authors.initials: VS
authors.lastname: Kostic
mesh_terms: D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D010396:Penicillamine / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography / Q000379:methods
chemical_list: D002614:Chelating Agents; D010396:Penicillamine