title: Mutational studies confirm the catalytic triad in the human selenoenzyme thioredoxin reductase predicted by molecular modeling.
authors.affiliation: Heidelberg University Biochemistry Center, Im Neuenheimer Feld 504, 69120 Heidelberg, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Gromer
authors.forename: Ludger A
authors.initials: LA
authors.lastname: Wessjohann
authors.forename: Jana
authors.initials: J
authors.lastname: Eubel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Brandt
mesh_terms: D001665:Binding Sites; D002384:Catalysis; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D009154:Mutation / Q000235:genetics; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D021122:Protein Subunits / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D051140:Selenoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D054481:Thioredoxin Reductase 1; D013880:Thioredoxin-Disulfide Reductase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D013879:Thioredoxins / Q000737:chemistry / Q000378:metabolism
chemical_list: D021122:Protein Subunits; D051140:Selenoproteins; D013879:Thioredoxins; C516124:TXNRD1 protein, human; D054481:Thioredoxin Reductase 1; D013880:Thioredoxin-Disulfide Reductase