Stereoselective functionalization of the 1'-position of 4'-thionucleosides.
Stereoselective synthesis of novel 1'-alpha-substituted-4'-thionucleosides was achieved starting from D-gulonic acid gamma-lactone via stereoselective nucleophilic substitution.
Gunaga
Prashantha
P
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Kim
Hea Ok
HO
Lee
Hyuk Woo
HW
Tosh
Dilip K
DK
Ryu
Jae-Sang
JS
Choi
Sun
S
Jeong
Lak Shin
LS
D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013400:Sugar Acids / Q000737:chemistry; D013872:Thionucleosides / Q000737:chemistry*
D013400:Sugar Acids; D013872:Thionucleosides; C007895:gulonolactone