title: Granular cell tumor arising metachronously in the bronchus and esophagus.
abstract: We present a case of granular cell tumor (GCT) occurring in the esophagus 7 years after operation for bronchial GCT. A 59-year-old Japanese man complained of epigastralgia, and endoscopic examination of the upper digestive tract disclosed a submucosal tumor in the lower esophagus. Histological examination of the endoscopic mucosal resection of the esophageal tumor showed a proliferation of neoplastic cells with an eosinophilic and granular cytoplasm. The cytoplasm of the neoplastic cells was histochemically positive for PAS stain and immunohistochemically positive for S-100. This tumor did not fulfill any of the diagnostic criteria for malignancy at either the macroscopic or microscopic level. I believe that this is the first case of GCT occurring metachronously in the respiratory and digestive tracts. Clinicians and pathologists should bear in mind that GCT may arise metachronously in the respiratory and digestive tracts.
authors.affiliation: Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Shinhonmachi 2-chome 13-51, Kochi City, Kochi 780-8562, Japan. nkurodakrch@yahoo.co.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.forename: Nao
authors.initials: N
authors.lastname: Kohno
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Iwamura
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Hamaguchi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohara
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirouchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Zuno
mesh_terms: D001984:Bronchial Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016586:Granular Cell Tumor / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
chemical_list: D009418:S100 Proteins