title: Comparison of high-performance liquid chromatography of cyclotriphosphazene derivatives with one or two equivalent stereogenic centres.
abstract: High-performance liquid chromatographic (HPLC) methods have been developed for investigating the stereogenic properties of two analogous series of dibenzylamino derivatives of cyclotriphosphazene containing either one or two equivalent stereogenic centres. Separation of the enantiomers of all the racemic compounds has been investigated by chiral HPLC using Whelk-01 and Chiralcel OD columns. In all cases, conditions for separation of enantiomers have been found using a Whelk-01 column with different ratios of tetrahydrofuran in n-hexane as the mobile phase. It is found that both the separation factor (alpha) and resolution factor (R(S)) of molecules with two equivalent stereogenic centres are greater than those for analogues with only one centre.
authors.affiliation: Department of Chemistry, Gebze Institute of Technology, Gebze 41400, Kocaeli, Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Beşli
authors.forename: David B
authors.initials: DB
authors.lastname: Davies
authors.forename: Adem
authors.initials: A
authors.lastname: Kiliç
authors.forename: Robert A
authors.initials: RA
authors.lastname: Shaw
authors.forename: Sule
authors.initials: S
authors.lastname: Sahin
authors.forename: Aylin
authors.initials: A
authors.lastname: Uslu
authors.forename: Serkan
authors.initials: S
authors.lastname: Yeşilot
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D015394:Molecular Structure; D009570:Nitriles / Q000032:analysis* / Q000737:chemistry; D017553:Phosphorus Compounds / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D013237:Stereoisomerism
chemical_list: D009570:Nitriles; D017553:Phosphorus Compounds; C068226:cyclotriphosphazene ester