Aspirin reduces platelet aggregation during high-energy excimer laser.
OBJECTIVE
Excimer laser is used clinically in arterial revascularization procedures. This study evaluated the efficacy of aspirin in reducing platelet aggregation during high-energy excimer lasing.


METHODS
Platelet rich plasma (PRP) from seven rabbits was circulated in a dual organ chamber with aspirin added to one and the other was control. PRP was irradiated using an excimer laser (308 nm; 45 mJ/mm(2); 25 Hz; 5 minutes) via a 2.0 mm laser catheter. Platelet aggregation (particle volume) was measured by laser-light scattering. Morphology was evaluated by phase contrast and electron microscopy.


RESULTS
Baseline platelet volume was 3.4 microm(3) for both control and aspirin groups. Following lasing, platelet volume peaked at 102.2 +/- 18.5 microm(3) for control compared to 43.1 +/- 49.2 microm(3) for aspirin-treated PRP (P < 0.0001).


CONCLUSIONS
Aspirin reduces large platelet aggregates but not small aggregates by 58% during lasing of PRP.
Huang
Ruiping
R
Division of Cardiology, Department of Medicine, Michigan State, University, East Lansing, Michigan 48824, USA.
Patel
Roshan B
RB
Ma
Hongbao
H
Taylor
Kevin
K
Abela
George S
GS
D000704:Analysis of Variance; D017222:Angioplasty, Balloon, Laser-Assisted; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D017536:Carotid Artery, Common / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004195:Disease Models, Animal; D010316:Particle Size; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010976:Platelet Count; D053657:Platelet-Rich Plasma / Q000187:drug effects; D011817:Rabbits
D015415:Biomarkers; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin