title: Interaction between warfarin and cranberry juice.
abstract: Warfarin is extensively used for anticoagulation to a target international normalized ratio of 2.0-3.0 for most indications or 2.5-3.5 for high-risk indications; however, many drugs and dietary supplements induce fluctuations in the international normalized ratio. Such fluctuations may lead to therapeutic failure or bleeding complications. Cranberry juice is increasingly used for the prevention and adjunctive treatment of urinary tract infections. The United Kingdom's Committee on Safety of Medicines has alerted clinicians to a potential interaction between warfarin and cranberry juice and has advised that patients avoid their concurrent use. Review and analysis of the literature revealed that ingestion of large volumes of cranberry juice destabilize warfarin therapy. Small amounts of juice are not expected to cause such an interaction. Clinicians should be aware of this potential interaction and monitor and counsel patients accordingly.
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Aston
authors.forename: Amy E
authors.initials: AE
authors.lastname: Lodolce
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Shapiro
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D001628:Beverages; D018565:Food-Drug Interactions; D006801:Humans; D019934:International Normalized Ratio; D029799:Vaccinium macrocarpon; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin