Trends in HIV postexposure prophylaxis prescription and compliance after sexual exposure in Amsterdam, 2000-2004.
OBJECTIVE
The objective of this study was to evaluate trends in HIV postexposure prophylaxis (PEP) requests after sexual exposure, compliance, and outcome of follow-up HIV tests.


METHODS
The authors conducted a retrospective analysis of all HIV PEP requests after sexual exposure between January 1, 2000, and December 31, 2004, in Amsterdam.


RESULTS
In 5 years, there was a very modest increase in PEP requests, of which most (75%) came from men who have sex with men (MSM). Although 70% reported side effects, 85% completed their PEP course. Sexual assault victims less often completed their course (odds ratio [OR] = 0.1; 95% confidence interval [CI] = 0.05-0.4, P = 0.001). People who used HIV PEP more often complied with follow-up tests than people who did not use PEP (OR = 3.5; 95% CI = 1.6-7.9, P = 0.002). One HIV seroconversion was found caused by a later exposure than that for which PEP was given.


CONCLUSIONS
Despite a widely available PEP program in Amsterdam, the number of PEP requests remained low. Most people completed their PEP course; compliance with follow-up HIV testing was high.
Sonder
Gerard J B
GJ
GGD Amsterdam, Municipal Health Service Amsterdam, Department of Infectious Diseases, Amsterdam, The Netherlands. gsonder@gggd.amsterdam.nl
van den Hoek
Anneke
A
Regez
Rosa M
RM
Brinkman
Kees
K
Prins
Jan M
JM
Mulder
Jan-Willem
JW
Veenstra
Jan
J
Claessen
Frans A
FA
Coutinho
Roel A
RA
D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D018890:Chemoprevention; D002648:Child; D019548:Crime Victims; D003695:Delivery of Health Care; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D008499:Medical Records; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*; D010349:Patient Compliance / Q000706:statistics & numerical data*; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012725:Sexual Behavior
D019380:Anti-HIV Agents