Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy.
We investigated an association between olfaction and cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD.
Lee
Phil Hyu
PH
Department of Neurology, Ajou University College of Medicine, Suwon, South Korea. phisland@chol.com
Yeo
Seung Hyeon
SH
Kim
Hyun Joon
HJ
Youm
Hyo Young
HY
D019797:3-Iodobenzylguanidine / Q000737:chemistry*; D000368:Aged; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009812:Odorants; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012903:Smell / Q000187:drug effects / Q000502:physiology*; D013223:Statistics as Topic
D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine