title: Depressive disorder with psychotic symptoms as psychiatric presentation of sporadic Creutzfeldt-Jakob disease: a case report.
abstract: Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease and shows a wide range of early clinical manifestation. We report the case of Ms. A, a 50-year-old woman, who exhibited an atypical psychiatric presentation of CJD at the beginning of the disease, as a depressive disorder with psychotic features. We discuss this case, the clinical attitudes that can lead to misdiagnose such presentation of CJD with other psychiatric diseases, and propose to repeat complementary investigations when the diagnostic is evocated, even if these tests are often negative or nonspecific in the early stages of CJD.
authors.affiliation: Child and Adolescent Psychiatry Department, Michel Fontan Clinic, rue André Verhaeghe, Lille University Hospital Centre, 59 037 Lille cedex, France. r.jardri@free.fr <r.jardri@free.fr>
authors.forename: Renaud
authors.initials: R
authors.lastname: Jardri
authors.forename: Claire
authors.initials: C
authors.lastname: DiPaola
authors.forename: Christine
authors.initials: C
authors.lastname: Lajugie
authors.forename: Pierre
authors.initials: P
authors.lastname: Thomas
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Goeb
mesh_terms: D000341:Affective Disorders, Psychotic / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology*; D000374:Aggression / Q000502:physiology; D001921:Brain / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000473:pathology / Q000523:psychology; D003951:Diagnostic Errors; D018450:Disease Progression; D004569:Electroencephalography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology*; D009460:Neurologic Examination; D010343:Patient Admission; D012017:Referral and Consultation