title: Before and after the spindle assembly checkpoint--an APC/C point of view.
abstract: On May 17-21, 2006 the Cold Spring Harbor Laboratory meeting on the cell cycle reunited over 350 researchers to discuss new findings in the cell cycle field. A common thread that connected numerous presentations was the regulation of the anaphase promoting complex/cyclosome (APC/C). This was also the main theme of the lecture given by the keynote speaker, Marc Kirschner (Harvard), who talked about "The unexpected importance of UbcH10 in both the G(1)/S transition and the initiation of anaphase", and it is also the main focus in this summary.
authors.affiliation: The Laboratory of Molecular and Cellular Biology, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health, Bethesda, Maryland 20892-0840, USA.
authors.forename: Armand
authors.initials: A
authors.lastname: de Gramont
authors.forename: Olivier
authors.initials: O
authors.lastname: Ganier
authors.forename: Orna
authors.initials: O
authors.lastname: Cohen-Fix
mesh_terms: D000705:Anaphase / Q000502:physiology; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology; D016193:G1 Phase / Q000502:physiology; D018816:Genes, cdc / Q000502:physiology*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D016196:S Phase / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology*; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; C105156:UBE2C protein, human; D044763:Ubiquitin-Conjugating Enzymes; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome