title: Novel intragenotype recombination in sapovirus.
abstract: Based on the genetic analysis, a novel, naturally occurring recombination between two distinct sapovirus subtypes (subtype a and subtype b) within genogroup I genotype 1 was identified. Breakpoint analysis of recombinant sapovirus showed that the recombination site was at the polymerase-capsid junction. This is the first report of the existence of acute gastroenteritis caused by intragenotype recombinant sapovirus. The results also provided evidence that the natural recombination occurs not only in sapovirus genogroup II but also in sapovirus genogroup I.
authors.affiliation: Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Tung Gia
authors.initials: TG
authors.lastname: Phan
authors.forename: Hainian
authors.initials: H
authors.lastname: Yan
authors.forename: Pattara
authors.initials: P
authors.lastname: Khamrin
authors.forename: Trinh Duy
authors.initials: TD
authors.lastname: Quang
authors.forename: Shuvra Kanti
authors.initials: SK
authors.lastname: Dey
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Yagyu
authors.forename: Shoko
authors.initials: S
authors.lastname: Okitsu
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ushijima
mesh_terms: D001483:Base Sequence; D005759:Gastroenteritis / Q000821:virology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic / Q000235:genetics*; D029341:Sapovirus / Q000145:classification / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D013045:Species Specificity