[MICA*008/A5.1 allele and HCMV infection in kidney transplanted donees of Hunan Han nationality].
OBJECTIVE
To investigate the relationship between MICA*008/A5.1 allele and human cytomegalovirus (HCMV) infection in kidney transplanted donees of Hunan Han nationality.


METHODS
The MICA*008/A5.1 allele based on 91 kidney transplanted donees and 81 unrelated normal individuals of Han nationality in Hunan Province were analyzed by PCR/SSP assay. At the same time, anti-HCMV antibody IgM was detected in the serum by ELISA method.


RESULTS
The positive rate of MICA*008/A5.1 allele was significantly higher in the control group (56.79%) than that in the kidney transplanted donee group (34.07%) (P <0.05). The infection rate of HCMV in those individuals whose genotype was MICA*008/A5.1 (-) was significantly higher than that in the MICA*008/A5.1(+).


CONCLUSIONS
The individual whose genotype is MICA*008/A5.1 (+) is not liable to HCMV infection, but the individual whose genotype is MICA*008/A5.1 (-) is liable to HCMV infection.
Huang
Bai-sheng
BS
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Luo
Qi-zhi
QZ
Li
Li-xin
LX
Mei
Bing
B
Zou
Yi-zhou
YZ
Wu
Li-xiang
LX
Yu
Ping
P
D000483:Alleles; D000914:Antibodies, Viral / Q000097:blood; D002681:China; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000235:genetics*; D005260:Female; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male
D000914:Antibodies, Viral; D015395:Histocompatibility Antigens Class I; D007075:Immunoglobulin M; C099187:MHC class I-related chain A