[The reaction of monoamines and sex hormones on vibration pathology and correction of this pathology with anabolic steroids].
The experiment was held on two groups of 40 grown-up white male rats. After the tests had bean finished by means of high-performance liquid chromatography method the quantity of monoamines (norepinephrine, serotonin and dopamine) was defined in hypothalamus, and the concentration of sex hormones (Follicle stimulating--FSH, Luteinizing hormone--LH, testosterone--T, estradiol--E(2)) was also defined by immunoferment method in the blood. The research showed that in both groups serotonin's level increased compared with the control group. In the first group its concentration increased to 147% and in the second one to 120%. As the rate of norepinephrine in the first group was increased by 41% against the background of anabolic steroid- -retabolil injections its concentration reduced to 90%. Its especially worth mentioning that as in the first case the concentration of dopamine was too reduced to 14% in the second case it made 70%. As a result of the research it was established that the concentration as T and E(2) as their regulator gonadotrophin hormones were decreased in the first group, but in condition of vibration pathology's correction with retabolil the rate of FSH and LH were within the norm, it follows that the rate of sexual steroids T and E(2) were within the norm.
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D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D015306:Biogenic Monoamines / Q000032:analysis / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000032:analysis / Q000378:metabolism*; D007031:Hypothalamus / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D051381:Rats; D013256:Steroids / Q000494:pharmacology; D014732:Vibration
D045930:Anabolic Agents; D015306:Biogenic Monoamines; D012739:Gonadal Steroid Hormones; D013256:Steroids; D009277:Nandrolone; D000077603:Nandrolone Decanoate