title: Comparative cytomorphology of skin, lymph node, liver and bone marrow in patients with lepromatous leprosy.
abstract: OBJECTIVE
  The aim of this study was to compare the cytological changes in skin, lymph nodes, liver and bone marrow in patients with lepromatous leprosy.
  
  
  METHODS
  Skin lesion, lymph node, liver and bone marrow aspirates were analysed. May-Grunwald-Giemsa (MGG) and Ziehl-Neelsen (Z-N) stains were employed. Comparative cytomorphology was studied.
  
  
  RESULTS
  Twenty patients with lepromatous leprosy were studied. Lepra cells (LC) predominated in the skin aspirates of 12 patients with lepromatous leprosy (LL), lymphocytes accompanied LC in eight patients with borderline-lepromatous (BL) leprosy. Three patients of LL leprosy and two of BL leprosy in type 2 reaction additionally had numerous neutrophils. Two patterns of lymph node aspirates were seen: partial replacement with few LC in a reactive lymphoid background (10), complete replacement with either only LC or LC in a background of degenerating neutrophils (10), the latter a feature of type 2 reaction. Liver aspiration was performed in seven patients and of bone marrow in eight patients. Occasional LC were present in five liver-aspirated patients, steatosis and Kupffer cell hyperplasia in four patients, and myelopoiesis in two patients. Bone marrow smears invariably had occasional LC and a relative increase in mature plasma cells; sea-blue histiocytes were seen in six patients.
  
  
  CONCLUSIONS
  Lepra cells predominated in skin and lymph node aspirates with complete replacement. In comparison, liver, bone marrow and lymph node aspirates with partial replacement were dominated by a preponderance of cells native to these organs with only few or occasional LC.
authors.affiliation: Department of Pathology and Dermatology, University College of Medical Sciences & GTB Hospital, Delhi, India.
authors.forename: N
authors.initials: N
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Bhatia
authors.forename: A
authors.initials: A
authors.lastname: Lakra
authors.forename: V K
authors.initials: VK
authors.lastname: Arora
authors.forename: S N
authors.initials: SN
authors.lastname: Bhattacharya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D015440:Leprosy, Lepromatous / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology*