In vitro antifungal susceptibility of clinical isolates of Candida spp. obtained from patients with different predisposing factors to candidosis.
The increase in the number of infections caused by Candida species and the consequent use of antifungal agents favours an increase of resistant isolates. The aim of this study was to evaluate the antifungal susceptibility of Candida spp. isolates from patients with different systemic predisposing factors to candidosis. Seventy-nine Candida spp. isolates were assayed for in vitro susceptibility to amphotericin B, fluconazole, 5-flucytosine and itraconazole using the technique proposed by the Clinical and Laboratory Standards Institute (CLSI). Four C. albicans, one C. guilliermondii, four C. parapsilosis and two C. tropicalis isolates were resistant to amphotericin B. Only two isolate was resistant to itraconazole. All the isolates tested were susceptible to fluconazole and flucytosine. It could be concluded that the most efficient drugs against the Candida isolates studied were fluconazole and flucytosine and that all of the antifungal agents used in this study were effective against the Candida spp. isolates tested.
Pinto
Patrícia M
PM
Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil. Av. Antonio Carlos, 6627, 31270-901, Belo Horizonte, MG, Brazil.
Weikert-Oliveira
Rita de Cássia Botelho
Rde C
Lyon
Juliana Pereira
JP
Cury
Verônica F
VF
Arantes
Rodrigo R
RR
Koga-Ito
Cristiane Y
CY
Resende
Maria A
MA
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D004198:Disease Susceptibility; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents