[Advances in the study of steroidogenic acute regulatory protein].
The steroidogenic acute regulatory (StAR) protein is an essential component in the regulation of steroid biosynthesis in adrenal and gonadal cells. The StAR protein has a high tissue specificity, located on the mitochondrial membranes of some relative cells. It regulates the transfer of cholesterin from extracellular into intracellular and plays a dominant role in steroidogenic synthesis. Recent studies have also shown that the transcription and expression of StAR are modulated not only through the cAMP-PKA dependent pathway, but also by multiple hormones and cytokines, which contributes to the regulation of cholesterin synthesis.
Wang
Cao-Ye
CY
Department of Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China. caoyewang@yahoo.com.cn
Wang
Yu-Bang
YB
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000378:metabolism; D005003:Ethisterone / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology*; D051381:Rats; D000098682:Steroidogenic Acute Regulatory Protein
D010750:Phosphoproteins; D000098682:Steroidogenic Acute Regulatory Protein; D002784:Cholesterol; D002786:Cholesterol Side-Chain Cleavage Enzyme; D005003:Ethisterone