Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies.
BACKGROUND
The revolution in molecular biology that has taken place over the past 2 decades has provided researchers with new and powerful tools for detailed study of the molecular mechanisms giving rise to the spectrum of pediatric brain tumors. Application of these tools has greatly advanced our understanding of the molecular pathogenesis of these lesions.


METHODS
After familiarizing readers with some promising new techniques in the field of oncogenomics, this review will present the current state of knowledge as it pertains to the molecular biology of pediatric brain neoplasms. Along the way, we hope to highlight specific instances where the detailed mechanistic knowledge acquired thus far may be exploited for therapeutic advantage.
Tamber
Mandeep S
MS
Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.
Bansal
Krishan
K
Liang
Muh-Lii
ML
Mainprize
Todd G
TG
Salhia
Bodour
B
Northcott
Paul
P
Taylor
Michael
M
Rutka
James T
JT
D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics* / Q000628:therapy; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D010372:Pediatrics