title: Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors.
abstract: Mast cells play a central role in inflammatory and allergic reactions by releasing inflammatory mediators through two main pathways, immunoglobulin E-dependent and -independent activation. In the latter, mast cells are activated by a diverse range of basic molecules, including peptides and amines such as substance P, neuropeptide Y, and compound 48/80. These secretagogues are thought to activate the G proteins in mast cells through a receptor-independent mechanism. Here, we report that the basic molecules activate G proteins through the Mas-related gene (Mrg) receptors on mast cells, leading to mast cell degranulation. We suggest that one of the Mrg receptors, MrgX2, has an important role in regulating inflammatory responses to non-immunological activation of human mast cells.
authors.affiliation: Department of Molecular Physiology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan. ktatemoto@ace.odn.ne.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tatemoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nozaki
authors.forename: Ryoko
authors.initials: R
authors.lastname: Tsuda
authors.forename: Shinobu
authors.initials: S
authors.lastname: Konno
authors.forename: Keiko
authors.initials: K
authors.lastname: Tomura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Furuno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ogasawara
authors.forename: Koji
authors.initials: K
authors.lastname: Edamura
authors.forename: Hideo
authors.initials: H
authors.lastname: Takagi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwamura
authors.forename: Masato
authors.initials: M
authors.lastname: Noguchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Naito
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002478:Cells, Cultured; D000071438:Fatty Acid-Binding Protein 7; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D043562:Receptors, G-Protein-Coupled / Q000276:immunology* / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D043562:Receptors, G-Protein-Coupled; D025521:Tumor Suppressor Proteins; D007073:Immunoglobulin E