Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure.
Trimetazidine (TMZ) is effective for the treatment of ischemic cardiomyopathy; however, little is known about the effect of TMZ in established injury-induced heart failure. When rats with established infarct-induced heart failure were treated for 12 weeks with TMZ there was no effect on left ventricular function or dilation, or on mRNA expression of fatty acid oxidation enzymes. On the other hand, TMZ significantly reduced atrial natriuretic peptide mRNA levels compared with untreated rats.
Morgan
Eric E
EE
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
Young
Martin E
ME
McElfresh
Tracy A
TA
Kung
Theodore A
TA
Hoit
Brian D
BD
Chandler
Margaret P
MP
Stanley
William C
WC
D042964:Acyl-CoA Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis* / Q000235:genetics; D002334:Carnitine O-Palmitoyltransferase / Q000235:genetics / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D010170:Palmitoyl-CoA Hydrolase / Q000235:genetics / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014292:Trimetazidine / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects
D012333:RNA, Messenger; D014665:Vasodilator Agents; D009320:Atrial Natriuretic Factor; D042964:Acyl-CoA Dehydrogenase; D002334:Carnitine O-Palmitoyltransferase; D011494:Protein Kinases; C403287:pyruvate dehydrogenase kinase 4; D010170:Palmitoyl-CoA Hydrolase; D014292:Trimetazidine