title: Early outcomes of coronary artery bypass with and without cardiopulmonary bypass in octogenarians.
abstract: BACKGROUND
  Off-pump coronary artery bypass (OPCAB) surgery has been successfully used in diverse patient populations and has been postulated to be safer than conventional coronary artery bypass (CCAB) surgery in some high-risk patients, including the elderly.
  
  
  OBJECTIVE
  To compare the safety of OPCAB surgery versus CCAB surgery in the octogenarian population of two large southwestern Ontario cardiac surgical units.
  
  
  RESULTS
  Two hundred thirty-six consecutive octogenarians underwent primary isolated coronary artery bypass surgery from November 2000 to March 2005. Patients undergoing OPCAB surgery tended to have higher Parsonnet scores, while patients undergoing CCAB surgery had a greater number of emergent operations. The Canadian Cardiovascular Network predicted that mortality risk was similar in both groups. In-hospital mortality was similar between groups, as was postoperative myocardial infarction and new onset of renal dysfunction. However, in the OPCAB group, there was a decreased incidence of postoperative neurological dysfunction (2.3% in the OPCAB group versus 10.5% in the CCAB group, P=0.01), in particular cerebrovascular accidents (1.5% in the OPCAB group versus 7.6% in the CCAB group, P=0.05), and a decreased incidence of prolonged intubation (5.3% in the OPCAB group versus 13.3% in the CCAB group, P=0.04). Multivariable analysis found that cardiopulmonary bypass had no significant impact on mortality or length of stay.
  
  
  CONCLUSIONS
  In octogenarian patients, OPCAB surgery is as safe as CCAB surgery in terms of mortality and major morbidity. Furthermore, a significant reduction in neurological dysfunction and prolonged intubation was seen in the OPCAB group compared with the CCAB group.
authors.affiliation: Division of Cardiac Surgery, London Health Sciences Centre, London, Ontario. adnagpal@uwo.ca
authors.forename: A D
authors.initials: AD
authors.lastname: Nagpal
authors.forename: G
authors.initials: G
authors.lastname: Bhatnagar
authors.forename: C A
authors.initials: CA
authors.lastname: Cutrara
authors.forename: S M
authors.initials: SM
authors.lastname: Ahmed
authors.forename: N
authors.initials: N
authors.lastname: McKenzie
authors.forename: M
authors.initials: M
authors.lastname: Quantz
authors.forename: B
authors.initials: B
authors.lastname: Kiaii
authors.forename: A
authors.initials: A
authors.lastname: Menkis
authors.forename: S
authors.initials: S
authors.lastname: Fox
authors.forename: L
authors.initials: L
authors.lastname: Stitt
authors.forename: R J
authors.initials: RJ
authors.lastname: Novick
mesh_terms: D000369:Aged, 80 and over; D000704:Analysis of Variance; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D047549:Coronary Artery Bypass, Off-Pump; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D016014:Linear Models; D008297:Male; D009864:Ontario / Q000453:epidemiology; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome