title: The role of noninvasive ventilation for acute respiratory failure.
abstract: The use of NIV has been shown to facilitate discontinuing ventilatory dependence as well as provide support for adult patients with chronic lung disease without the need for endotracheal intubation. In fact, NIV has recently described as a potential support strategy following extubation failure. Therefore, using NIV as a bridge to liberation from mechanical ventilation may decrease many of the complications associated with long-term use of invasive airway devices as well complications from reinsertion of an artificial airway. Although firm data supporting the use of NIV in the adult population exists, the use of NIV in the pediatric population is based primarily on a series of case studies, retrospective chart reviews, and extrapolation from the adult data. The use of NIV for infants and children remains controversial. The important question to be asked is why there is a lack of randomized controlled trials on NIV in pediatrics? The answer lies somewhere between the lack of equipment designed specifically for pediatrics and the smaller number of patients available compared with adults. Data from the adult population may be more readily adapted to older children; however, it remains difficult to determine the criteria for noninvasive ventilatory use in infants and young children. In fact, this lack of data makes the formulation of firm selection guidelines for infants and children essentially impossible. However, for a select groups of pediatric patients with acute respiratory failure for whom an appropriate noninvasive device with interface is available, a trial of NIV may be seem reasonable to avoid the known negative effects of intubation and invasive mechanical ventilation.
authors.affiliation: Pediatric Critical Care Medicine, Duke Children's Hospital, Box 3046, Durham, NC 27710, USA. hamel003@mc.duke.edu
authors.forename: Donna S
authors.initials: DS
authors.lastname: Hamel
authors.forename: Hilary
authors.initials: H
authors.lastname: Klonin
mesh_terms: D000075202:Contraindications; D004867:Equipment Design; D006801:Humans; D007442:Intubation, Intratracheal; D012121:Respiration, Artificial / Q000295:instrumentation / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D016896:Treatment Outcome