Dose-dependent effects of peptide YY(3-36) on conditioned taste aversion in rats.
We used a conditioned taste aversion test to assess whether PYY(3-36) reduces food intake by producing malaise. Two-hour IV infusion of PYY(3-36) (8, 15, and 30 pmol/kg/min) at dark onset in non-food-deprived rats produced a dose-dependent inhibition of feeding and a conditioned aversion to the flavored chow paired with PYY(3-36) infusion. In food-deprived rats, PYY(3-36) at 2 and 4 pmol/kg/min inhibited intake of a flavored saccharin solution without producing conditioned taste aversion, whereas higher doses (8 and 15 pmol/kg/min) inhibited saccharin intake and produced taste aversion. These results suggest that anorexic doses of PYY(3-36) may produce a dose-dependent malaise in rats, which is similar to that reported for PYY(3-36) infusion in humans. Previous studies have shown that PYY(3-36) potently inhibits gastric emptying, and that gut distention can produce a conditioned taste aversion. Thus, PYY(3-36) may produce conditioned taste aversion in part by slowing gastric emptying.
Chelikani
Prasanth K
PK
Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
Haver
Alvin C
AC
Reidelberger
Roger D
RD
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003216:Conditioning, Operant; D004305:Dose-Response Relationship, Drug; D007262:Infusions, Intravenous; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000502:physiology*; D019894:Peptide YY / Q000008:administration & dosage / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000502:physiology*
D010446:Peptide Fragments; D019894:Peptide YY