Dietary mineral and trace element intake and squamous cell carcinoma of the esophagus in a Chinese population.
Few studies have been conducted in low-selenium areas of China to assess the relationships between dietary intake of selenium and zinc and the risk of squamous cell carcinoma of the esophagus (SCCE). We studied dietary mineral and trace element intake and risk of SCCE in a population- based, case-control study in Taixing, China, in 2000. A total of 218 SCCE patients and 415 population healthy controls were interviewed using a standard dietary and health questionnaire. The median and quartiles were calculated to represent the average level and distribution of selected dietary minerals and trace elements estimated by the Chinese Standard Tables of Food Composition. The adjusted odds ratios (ORs) comparing the highest with the lowest quartiles were 0.30 (95% confidence intervals, CIs = 0.13-0.67) for selenium intake and 0.28 (95% CI = 0.11-0.70) for zinc intake with obvious dose-dependent patterns (P values for trend = 0.01). The adjusted OR for the combined effect of selenium and zinc intake was 0.53 (95% CI = 0.29-0.96) after controlling for potential confounding factors, including age, gender, educational level, body mass index, and total energy intake. Our results suggested that the potential joint effect of zinc and selenium might contribute to SCCE risk. Increased dietary intake of selenium and zinc may decrease the risk of SCCE in a low-selenium area of China.
Lu
Hua
H
Department of Epidemiology, Fujian Medical University, Fujian, Fuzhou, China.
Cai
Lin
L
Mu
Li-Na
LN
Lu
Qing-Yi
QY
Zhao
Jinkou
J
Cui
Yan
Y
Sul
James H
JH
Zhou
Xue-Fu
XF
Ding
Bao-Guo
BG
Elashoff
Robert M
RM
Marshall
James
J
Yu
Shun-Zhang
SZ
Jiang
Qing-Wu
QW
Zhang
Zuo-Feng
ZF
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000008:administration & dosage; D016017:Odds Ratio; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D014131:Trace Elements / Q000008:administration & dosage*; D015032:Zinc / Q000008:administration & dosage*
D008903:Minerals; D014131:Trace Elements; D012643:Selenium; D015032:Zinc