title: Argon beam coagulation as an adjuvant for local control of giant cell tumor.
abstract: The argon beam coagulator is gaining popularity as an adjuvant therapy for treatment of giant cell tumors of bone. However, the effectiveness and functional implications of this treatment have not been assessed. To determine whether the argon beam coagulator could be a viable adjuvant treatment option, we examined the recurrence rate and functional outcome of patients with giant cell tumors who were treated with the argon beam coagulator, as an adjuvant to curettage and cementation. Thirty-seven patients who received argon beam coagulation as an adjuvant treatment for giant cell tumors diagnosed between 1993 and 2000 were identified. The median age of the patients was 32 years (range, 16-64 years). The mean followup was 73.7 months (range, 0.5-108 months). Three patients had osseous recurrences (8.3%) and one had a soft tissue recurrence. The 5-year Kaplan-Meier disease-free survival estimate was 87.2% (95% confidence interval, range, 76.3-99.8). No patient had radiographic evidence of arthritis. The average Musculoskeletal Tumor Society score was 28. Short form-36 evaluation showed no change in functional or mental perception in these patients compared with US norms. These data suggest argon beam coagulation as an adjuvant therapy is associated with in a low rate of local recurrence and is a reasonable adjuvant treatment option.
authors.affiliation: MD Anderson Cancer Center, Houston, TX, USA. volewis@mdanderson.org
authors.forename: Valerae O
authors.initials: VO
authors.lastname: Lewis
authors.forename: Anthony
authors.initials: A
authors.lastname: Wei
authors.forename: Tito
authors.initials: T
authors.lastname: Mendoza
authors.forename: Frank
authors.initials: F
authors.lastname: Primus
authors.forename: Terrance
authors.initials: T
authors.lastname: Peabody
authors.forename: Michael A
authors.initials: MA
authors.lastname: Simon
mesh_terms: D000293:Adolescent; D000328:Adult; D001128:Argon; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000473:pathology / Q000601:surgery*; D006801:Humans; D053208:Kaplan-Meier Estimate; D017075:Laser Coagulation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D001128:Argon