title: Transcriptional response of Escherichia coli to TPEN.
abstract: DNA microarrays were used to probe the transcriptional response of Escherichia coli to N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN). Fifty-five transcripts were significantly up-regulated, including all of the genes that are regulated by Zur and many that are regulated by Fur. In the same TPEN-treated cells, 46 transcripts were significantly down-regulated.
authors.affiliation: Department of Chemistry and Biochemistry, 160 Hughes Hall, Miami University, Oxford, OH 45056, USA.
authors.forename: Tara K
authors.initials: TK
authors.lastname: Sigdel
authors.forename: J Allen
authors.initials: JA
authors.lastname: Easton
authors.forename: Michael W
authors.initials: MW
authors.lastname: Crowder
mesh_terms: D000222:Adaptation, Physiological; D015536:Down-Regulation; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D005029:Ethylenediamines / Q000494:pharmacology*; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D007502:Iron Chelating Agents / Q000494:pharmacology*; D020411:Oligonucleotide Array Sequence Analysis; D014158:Transcription, Genetic / Q000187:drug effects*; D015854:Up-Regulation
chemical_list: D005029:Ethylenediamines; D007502:Iron Chelating Agents; C044387:N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine