Broad range analysis of endocrine disruptors and pharmaceuticals using gas chromatography and liquid chromatography tandem mass spectrometry.
Endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) have been globally detected in impacted natural waters. The detection of trace quantities of EDCs and PPCPs in the environment is of great concern since some of these compounds have known physiological responses at low concentrations. EDCs can have a wide range of polarities, acidic and basic moieties, and exist in trace quantities, which often requires numerous complex extractions, large sample collection volumes, and multiple instrumental analyses. A comprehensive method has been developed allowing for the analysis of 58 potential EDCs in various water matrices using a single solid-phase extraction (SPE) of a 1L sample with subsequent analyses using both gas chromatography and liquid chromatography, each coupled with tandem mass spectrometry (GC-MS/MS and LC-MS/MS). Instrument detection limits ranged between 0.12-7.5 pg with corresponding method reporting limits of 1-10 ng l(-1) in water. Recoveries for most compounds were between 50% and 112% with good reproducibility (RSD 6-22%).
Trenholm
Rebecca A
RA
Water Quality Research and Development Department, Southern Nevada Water Authority, 1350 Richard Bunker Avenue, Henderson, NV 89015, USA. beck.trenholm@snwa.com
Vanderford
Brett J
BJ
Holady
Janie C
JC
Rexing
David J
DJ
Snyder
Shane A
SA
D002853:Chromatography, Liquid / Q000379:methods*; D052244:Endocrine Disruptors / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014874:Water Pollutants, Chemical / Q000032:analysis*
D052244:Endocrine Disruptors; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical