title: Interactions of cytokines, S-Adenosylmethionine, and S-Adenosylhomocysteine in alcohol-induced liver disease and immune suppression.
abstract: Alcoholic liver disease (ALD) remains a leading cause of death in the USA. Defining mechanisms for liver cell death in ALD in order to develop potential new agents for therapeutic intervention is a major focus of the authors' work. Abnormal cytokine metabolism is a major feature of ALD, and a thorough understanding of both mechanisms and interactions of cytokine overproduction and sensitization are critical to developing a possible treatment for ALD. S-Adenosylmethionine has been used in a variety of animal studies and clinical trials and has been reported to improve biochemical parameters of liver function. Last, immunosuppression associated with chronic alcohol abuse is an important predisposing factor to opportunistic infections and cancer. It is the authors' working hypothesis that alcohol consumption leads to chronic activation of the immune system.
authors.affiliation: Department of Medicine, University of Louisville, Louisville, Kentucky 40292, USA.
authors.forename: Shirish
authors.initials: S
authors.lastname: Barve
authors.forename: Swati
authors.initials: S
authors.lastname: Joshi-Barve
authors.forename: Zhenyuan
authors.initials: Z
authors.lastname: Song
authors.forename: Daniell
authors.initials: D
authors.lastname: Hill
authors.forename: Prachi
authors.initials: P
authors.lastname: Hote
authors.forename: Ion
authors.initials: I
authors.lastname: Deaciuc
authors.forename: Craig
authors.initials: C
authors.lastname: McClain
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D008108:Liver Diseases, Alcoholic / Q000276:immunology* / Q000378:metabolism*; D012435:S-Adenosylhomocysteine / Q000378:metabolism*; D012436:S-Adenosylmethionine / Q000378:metabolism*
chemical_list: D016207:Cytokines; D012436:S-Adenosylmethionine; D012435:S-Adenosylhomocysteine