title: Acrylic bone cements with bismuth salicylate: Behavior in simulated physiological conditions.
abstract: In a previous work, we reported the development of acrylic bone cement formulations for application in percutaneous vertebroplasty, by using bismuth salicylate (BS) as the radiopaque agent. Our objective was to obtain high radiopacity along with a therapeutical effect produced by the release of salicylic acid in situ. To follow that study, the setting kinetics and static and dynamical mechanical properties of the BS cements were studied in simulated physiological conditions. Moreover, radiopacity after various times of immersion in saline and the wettability of the cements surfaces were determined. The study finished with the analysis of the biological response. From the results, it can be concluded that physiological conditions did not affect negatively to the cements performance, since all BS-loaded cements fulfilled the ISO standard requirements. Radiopacity of the formulations was maintained over time and cements with BS were found to be biocompatible.
authors.affiliation: Dpto. Ciencia y Tecnología de Polímeros, POLYMAT (Institute of Polymeric Materials), Facultad de Química, Universidad del País Vasco, Apdo. 1072, San Sebastián 20080, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Hernández
authors.forename: B
authors.initials: B
authors.lastname: Vázquez
authors.forename: A
authors.initials: A
authors.lastname: López-Bravo
authors.forename: J
authors.initials: J
authors.lastname: Parra
authors.forename: I
authors.initials: I
authors.lastname: Goñi
authors.forename: M
authors.initials: M
authors.lastname: Gurruchaga
mesh_terms: D000179:Acrylates; D000818:Animals; D001843:Bone Cements / Q000737:chemistry / Q000592:standards*; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007700:Kinetics; D008422:Materials Testing; D019563:Mechanics; D012459:Salicylates; D012965:Sodium Chloride; D013499:Surface Properties; D017155:Wettability
chemical_list: D000179:Acrylates; D001843:Bone Cements; D012459:Salicylates; D012965:Sodium Chloride; C036658:acrylic acid; C496893:Bismuth Salicylate