Depressive and memory symptoms as presenting features of spinocerebellar ataxia.
The spinocerebellar ataxias (SCA) can be manifested in neuropsychiatric symptoms. Among 76 SCA patients presenting to a university ataxia center, depressive symptoms characterized SCA3. Memory symptoms occurred across all SCA groups with relative sparing of SCA6. These differences in neuropsychiatric symptoms suggest the subtype of SCA and the corresponding neuropathological involvement.
McMurtray
Aaron M
AM
Department of Neurology, University of California at Los Angeles (UCLA), USA. aaronmnm@hawaii.edu
Clark
David G
DG
Flood
Mary K
MK
Perlman
Susan
S
Mendez
Mario F
MF
D000328:Adult; D003863:Depression / Q000209:etiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000523:psychology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D020754:Spinocerebellar Ataxias / Q000150:complications* / Q000235:genetics / Q000523:psychology*