Microarrays: a monitoring tool for transplant patients?
Microarray technology holds a distinct advantage over traditional genomic methods, with the unique capability to rapidly generate multiple global gene expression profiles in parallel. This technology is quickly gaining widespread use in many areas of science and medicine because it can be easily adapted to study many experimental questions, particularly relating to disease heterogeneity. Microarray experiments have begun to advance our understanding of the underlying molecular processes in solid organ transplantation; however, several obstacles must be overcome before this technology is ready for application in the clinical setting. This article will review the current applications of microarray technology in the field of transplantation, and discuss the potential impact of this technology on monitoring of solid organ transplant recipients.
Weintraub
Lauren A
LA
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA.
Sarwal
Minnie M
MM
D006801:Humans; D016030:Kidney Transplantation / Q000379:methods; D008954:Models, Biological; D025202:Molecular Diagnostic Techniques; D008991:Monitoring, Physiologic / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D014019:Tissue Donors; D014180:Transplantation / Q000379:methods*; D014181:Transplantation Immunology; D019737:Transplants