title: In vitro protoscolicidal effects of hypertonic glucose on protoscolices of hydatid cyst.
abstract: To evaluate the protoscolicidal effects of various concentrations of hypertonic glucose, live protoscolices of sheep were exposed to 10%, 15%, 25% and 50% glucose solutions. Cetrimide (0.5%), silver nitrate (0.5%) and hypertonic saline (20%) were used as positive controls, while physiological saline was used as a negative control. After 1, 2 and 5 min, the protoscolicidal effects were determined by 1% eosin. A 25% glucose solution had no significant protoscolicidal effect. However, a 50% glucose solution revealed higher protoscolicidal effect than 0.5% silver nitrate but weaker effect than 0.5% cetrimide; the effect was comparable with that of 20% hypertonic saline. The results showed that hypertonic glucose solution is highly effective in killing protoscolices of Echinococcus granulosus in vitro.
authors.affiliation: Department of Surgery, Gastroenterohepatology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. hoseiniv@sums.ac.ir
authors.forename: Seyed Vahid
authors.initials: SV
authors.lastname: Hosseini
authors.forename: Kurosh
authors.initials: K
authors.lastname: Ghanbarzadeh
authors.forename: Jahra
authors.initials: J
authors.lastname: Barzin
authors.forename: Seyed Mahmoud
authors.initials: SM
authors.lastname: Sadjjadi
authors.forename: Nader
authors.initials: N
authors.lastname: Tanideh
authors.forename: Davood
authors.initials: D
authors.lastname: Mehrabani
mesh_terms: D000818:Animals; D004443:Echinococcosis / Q000469:parasitology*; D048209:Echinococcus granulosus / Q000187:drug effects* / Q000302:isolation & purification; D005950:Glucose Solution, Hypertonic / Q000494:pharmacology*; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology*
chemical_list: D005950:Glucose Solution, Hypertonic