Studies on autoprothrombin C thrombin relationship.
In every prothrombin activation two different enzymatic reactions can be distinguished. The first reaction is the prothrombin disappearance and the second one is the thrombin formation. Autoprothrombin C catalyzes both reactions and thrombin only the first one. The inhibition of thrombin with heparin allows a more complete activation of the thrombin. The two reactions can be independently catalyzed by different substances. Heparin by itself can provide the environment for activation.
Landaburu
R H
RH
Institute of Pharmacology, National University of Córdoba, Córdoba, Argentina.
Abdala
O
O
Fulginiti
S
S
Curtino
J
J
D000818:Animals; D002417:Cattle; D004789:Enzyme Activation; D015951:Factor Xa / Q000378:metabolism*; D006493:Heparin / Q000494:pharmacology; D007700:Kinetics; D013917:Thrombin / Q000378:metabolism*
D006493:Heparin; D013917:Thrombin; D015951:Factor Xa