Modulating the outer membrane with small RNAs.
MicF, one of the first chromosomally encoded regulatory small RNAs (sRNAs) to be discovered, was found to modulate the expression of OmpF, an abundant outer membrane protein. Several recent papers have now shown that this is not an isolated case. At least five other sRNAs also regulate the synthesis of outer membrane porins, and additional sRNAs modulate the expression of other outer membrane proteins. Here we review what is known about these sRNAs and discuss the implications of this regulation.
Guillier
Maude
M
Laboratory of Molecular Biology, National Cancer Institute, Bethesda 20892, Maryland, USA.
Gottesman
Susan
S
Storz
Gisela
G
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D002473:Cell Wall / Q000235:genetics* / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D012329:RNA, Bacterial / Q000502:physiology*
D001425:Bacterial Outer Membrane Proteins; D012329:RNA, Bacterial