title: Mice naturally resistant to Yersinia pestis Delta pgm strains commonly used in pathogenicity studies.
abstract: We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Deltapgm strains of Yersinia pestis; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536-0298, USA.
authors.forename: Yasemin H K
authors.initials: YH
authors.lastname: Congleton
authors.forename: Christine R
authors.initials: CR
authors.lastname: Wulff
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Kerschen
authors.forename: Susan C
authors.initials: SC
authors.lastname: Straley
mesh_terms: D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D010930:Plague / Q000235:genetics / Q000276:immunology* / Q000382:microbiology* / Q000401:mortality; D015010:Yersinia pestis / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity