Vesicle formation at the plasma membrane and trans-Golgi network: the same but different.
An elaborate vesicle transport system supports the active exchange of membranes and protein cargo between the plasma membrane and the trans-Golgi network. Many observations suggest that highly conserved mechanisms are used in vesicle formation and scission. Such similarity is found both at the level of the receptor-ligand sequestration process that uses clathrin and associated polymeric and monomeric adaptor proteins, and in the machinery used to deform and vesiculate lipid membranes.
McNiven
Mark A
MA
Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. mcniven.mark@mayo.edu
Thompson
Heather M
HM
D033942:Adaptor Proteins, Vesicular Transport / Q000737:chemistry / Q000378:metabolism*; D020816:Amino Acid Motifs; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D022163:Clathrin-Coated Vesicles / Q000378:metabolism* / Q000648:ultrastructure; D004705:Endocytosis; D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism; D021962:Membrane Microdomains / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D008954:Models, Biological; D021381:Protein Transport; D022161:Transport Vesicles / Q000378:metabolism* / Q000648:ultrastructure; D021601:trans-Golgi Network / Q000378:metabolism* / Q000648:ultrastructure
D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; D008563:Membrane Lipids; D008840:Microfilament Proteins