Evaluation of methods for the determination of water in substances with unknown chemical and thermal behaviour.
The water content of six different substances was determined by means of five different methods. The methods used were loss on drying, thermogravimetry (coupled with DSC), a new phosphorous-pentoxide method, direct Karl-Fischer titration and the Karl-Fischer oven. A combination of direct Karl-Fischer titration and the KF-oven method was found to be the optimal technique for water determination of substances of unidentified chemical and thermal behaviour based on detailed considerations about selectivity, type of water binding, sample properties and efficiency.
Hinz
Dirk Christian
DC
Schering AG, Global Chemical Development, In-Process Control Department, 13342 Berlin, Germany. dirk.hinz@schering.de
D002152:Calorimetry, Differential Scanning; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D003890:Desiccation; D008278:Magnesium Sulfate / Q000737:chemistry; D009705:Nucleosides / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry; D017553:Phosphorus Compounds / Q000737:chemistry; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry; D013696:Temperature; D013818:Thermogravimetry; D013997:Time Factors; D017186:Titrimetry / Q000379:methods; D014867:Water / Q000032:analysis*
D009705:Nucleosides; D009943:Organophosphorus Compounds; D017553:Phosphorus Compounds; D010879:Piperazines; D014867:Water; D000077489:Piperazine; C061896:triphenylphosphine; C012500:phosphorus pentoxide; D008278:Magnesium Sulfate