Targeting protein stability with a small molecule.
Both genetic approaches and small-molecule inhibitors can be used to perturb protein function. Banaszynski et al. (2006) now describe a strategy to regulate the stability of a target protein, in which specificity is provided by a genetically encoded tag and temporal control is imparted by a small molecule.
Lampson
Michael A
MA
Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10021, USA.
Kapoor
Tarun M
TM
D000818:Animals; D005786:Gene Expression Regulation; D008024:Ligands; D008164:Luminescent Proteins / Q000235:genetics; D051379:Mice; D009154:Mutation; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011993:Recombinant Fusion Proteins / Q000378:metabolism*; D020123:Sirolimus / Q000737:chemistry / Q000378:metabolism; D022061:Tacrolimus Binding Protein 1A / Q000737:chemistry / Q000235:genetics*; D022021:Tacrolimus Binding Proteins / Q000737:chemistry / Q000235:genetics*
D008024:Ligands; D008164:Luminescent Proteins; D011993:Recombinant Fusion Proteins; D046988:Proteasome Endopeptidase Complex; D022061:Tacrolimus Binding Protein 1A; D022021:Tacrolimus Binding Proteins; D020123:Sirolimus