Synthesis of steroidal lactone by penicillium citreo-viride.
The biotransformations of a series of steroids by the fungus penicillium citreo-viride A.C.C.C. 0402 have been investigated, and the conversion to the same product testolactone (1) was observed from progesterone (2), dehydroepiandrosterone (3), 4-androstene-3, 17-dione (4), 5-androstene-3, 17-diol (5) with the exception of pregnenolone (6) and 3beta-hydroxy-5, 16-pregnadien-20-one (7). The possible metabolic pathways of the biotransformations were also discussed in the paper and the fungus penicillium citreo-viride A.C.C.C. 0402 was isolated during screening stains from samples collected from Zhengzhou, Henan province of China.
Liu
Hong-Min
HM
New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450052, China. liuhm@public2.zz.ha.cn
Li
Heping
H
Shan
Lihong
L
Wu
Jian
J
D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D010407:Penicillium / Q000378:metabolism*; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*
D007783:Lactones; D013256:Steroids