Collagenase and surgical disease.
Collagen types I, II, and III are the most abundant extracellular matrix (ECM) proteins. Collagenase is a member of the matrix metalloproteinase (MMP) family of enzymes, and is the principal enzyme involved with collagen degradation. Cellular-ECM interactions are vitally important to tissue structure and function. In this review, we summarize recent work that highlights the role of collagenase in ECM remodeling and repair, and further report that alterations of collagenase expression, function, and/or regulation are found in many diverse disease states, including aortic aneurysms, tumor invasiveness and their metastases, and hernias. Collagenase is intimately involved in many surgical diseases, and represents a potential target for therapy.
Donahue
Timothy R
TR
Division of General Surgery, David Geffen School of Medicine at UCLA, Box 956904, 72-160 CHS, Los Angeles, CA 90095-6904, USA.
Hiatt
Jonathan R
JR
Busuttil
Ronald W
RW
D000818:Animals; D003094:Collagen / Q000502:physiology*; D017364:Collagenases / Q000378:metabolism; D018450:Disease Progression; D006547:Hernia / Q000378:metabolism*; D059685:Herniorrhaphy; D006801:Humans; D014945:Wound Healing / Q000502:physiology
D003094:Collagen; D017364:Collagenases