title: Cytotoxic constituents from Butea superba Roxb.
abstract: A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC(50) (microM) values of 37.3+/-2.5 and 71.1+/-0.8 and on BC cell lines with IC(50) (microM) values of 32.7+/-1.5 and 47.3+/-0.3, respectively.
authors.affiliation: Research Centre for Bioorganic Chemistry, Faculty of Science, Chulalongkorn University, Pyathai Road, Pathumwan, Bangkok, Thailand. nnattaya@chula.ac.th
authors.forename: Nattaya
authors.initials: N
authors.lastname: Ngamrojanavanich
authors.forename: Aimon
authors.initials: A
authors.lastname: Loontaisong
authors.forename: Somchai
authors.initials: S
authors.lastname: Pengpreecha
authors.forename: Wichai
authors.initials: W
authors.lastname: Cherdshewasart
authors.forename: Surachai
authors.initials: S
authors.lastname: Pornpakakul
authors.forename: Khanitha
authors.initials: K
authors.lastname: Pudhom
authors.forename: Sophon
authors.initials: S
authors.lastname: Roengsumran
authors.forename: Amorn
authors.initials: A
authors.lastname: Petsom
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D031290:Butea / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology; D008518:Medicine, East Asian Traditional; D036343:Pterocarpans / Q000737:chemistry / Q000494:pharmacology; D013785:Thailand; D000094162:Phytoalexins
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007529:Isoflavones; D036343:Pterocarpans; C083295:prunetin; C007768:formononetin; C047353:medicarpin; D000094162:Phytoalexins