title: Osteoporosis: how should it be treated?
abstract: Osteoporosis develops as a result of imbalance between bone resorption and bone formation. A number of effective and safe therapies for osteoporosis are currently available, most of which are inhibitors of bone resorption. However, because osteoporosis is a complex and heterogeneous disease with different pathogenetic factors, defining the role of the different factors in its development is important in formulating a more selective approach to therapy. This review discusses the advantages and disadvantages of the currently available agents used in the management of osteoporosis.
authors.affiliation: Center for Mineral Metabolism, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8885, USA. clarita.odvina@utsouthwestern.edu
authors.forename: Clarita V
authors.initials: CV
authors.lastname: Odvina
mesh_terms: D015519:Bone Density; D001862:Bone Resorption / Q000517:prevention & control; D002116:Calcitonin / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000627:therapeutic use; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology; D010281:Parathyroid Hormone / Q000627:therapeutic use; D010446:Peptide Fragments / Q000627:therapeutic use; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use
chemical_list: D004164:Diphosphonates; D004967:Estrogens; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D020849:Raloxifene Hydrochloride; D002116:Calcitonin