title: Long-term outcomes of malignant phyllodes tumors patients: an institutional experience.
abstract: BACKGROUND
  Malignant phyllodes tumors are an extremely rare breast tumor. Prognostic features and overall survival data have not been consistent across studies.
  
  
  METHODS
  Retrospectively, we examined the clinicopathologic features of 27 breast cancer patients treated for malignant phyllodes tumors from 1995 to 2004 and analyzed their recurrence and survival outcomes using contingency tables, a logistic regression model, or a proportional hazard model.
  
  
  RESULTS
  The mortality rate was 12% (n = 3) of the cohort and 75% of the group with distant metastases. The median follow-up period was 51 months (range, 12-192 mo). A mitotic index greater than 10 per high-powered field, the presence of stromal overgrowth, mastectomy at initial surgery, and larger tumor size were associated with an increased incidence of distant metastases. Larger tumor size also was associated with an increased incidence of death.
  
  
  CONCLUSIONS
  Most patients with malignant phyllodes tumors will enjoy significant long-term survival if treated appropriately with local excision with clear margins.
authors.affiliation: Columbia-Presbyterian Comprehensive Breast Center, New York, NY, USA. adorafou.md@gmail.com
authors.forename: Adora
authors.initials: A
authors.lastname: Fou
authors.forename: Freya R
authors.initials: FR
authors.lastname: Schnabel
authors.forename: Diane
authors.initials: D
authors.lastname: Hamele-Bena
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Wei
authors.forename: Bin
authors.initials: B
authors.lastname: Cheng
authors.forename: Mahmoud
authors.initials: M
authors.lastname: El Tamer
authors.forename: Laura
authors.initials: L
authors.lastname: Klein
authors.forename: Kathie Ann
authors.initials: KA
authors.lastname: Joseph
mesh_terms: D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D003557:Phyllodes Tumor / Q000401:mortality* / Q000556:secondary* / Q000628:therapy; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome