UCP3 in muscle wasting, a role in modulating lipotoxicity?
UCP3 has been postulated to function in the defense against lipid-induced oxidative muscle damage (lipotoxicity). We explored this hypothesis during cachexia in rats (zymosan-induced sepsis), a condition characterized by increased oxidative stress and supply of fatty acids to the muscle. Muscle UCP3 protein content was increased 2, 6 and 11 days after zymosan injection. Plasma FFA levels were increased at day 2, but dropped below control levels on days 6 and 11. Muscular levels of the lipid peroxidation byproduct 4-hydroxy-2-nonenal (4-HNE) were increased at days 6 and 11 in zymosan-treated rats, supporting a role for UCP3 in modulating lipotoxicity during cachexia.
Minnaard
Ronnie
R
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Schrauwen
Patrick
P
Schaart
Gert
G
Hesselink
Matthijs K C
MK
D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D002100:Cachexia / Q000139:chemically induced / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D007473:Ion Channels / Q000096:biosynthesis*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D024101:Mitochondrial Proteins / Q000096:biosynthesis*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000139:chemically induced / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000139:chemically induced / Q000378:metabolism*; D000071247:Uncoupling Protein 3; D019282:Wasting Syndrome / Q000139:chemically induced / Q000378:metabolism*; D015054:Zymosan / Q000494:pharmacology / Q000633:toxicity
D000447:Aldehydes; D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604392:UCP3 protein, human; C000604394:Ucp3 protein, rat; D000071247:Uncoupling Protein 3; D015054:Zymosan; C027576:4-hydroxy-2-nonenal