title: [Repetitive instillation of 0.1% cyclosporin A eye drops induces miosis and anterior chamber inflammation-like reactions in monkey eyes].
abstract: OBJECTIVE
  Miosis and anterior chamber inflammation-like reactions were recognized after six instillations of 0.1% cyclosporin A eye drops every 30 minutes into rabbit conjunctival sacs. In order to consider species specificity, 0.1% cyclosporin A eye drops were applied by the same method in monkeys.
  
  
  METHODS
  Eye drops were applied in five monkeys (monkey A, B, C, D, E); in one eye as control and in nine eyes with 0.1% cyclosporin A. We investigated the changes of pupil diameter, intraocular pressure, and anterior chamber flare before and after applying the eye drops. We also examined the effect on ocular tissue histopathologically.
  
  
  RESULTS
  Miosis was recognized in six eyes, but no significant intraocular pressure change was observed in any eyes. In both eyes of monkey A anterior chamber flare increased significantly, and flare increased slightly in both eyes of monkeys B, C, and D. On the other hand, there was no change in either eye of monkey E, including the control eye. Localized necrosis of nonpigmented ciliary epithelium was recognized at the beginning of the ciliary process in both eyes of monkey A. Mild cystoid degeneration of nonpigmented ciliary epithelium was seen at the beginning of the ciliary process in the right eye of monkey C, and in the left eye of monkey D.
  
  
  CONCLUSIONS
  No species specificity can be recognized in monkeys from the fact that there is the selective destruction of nonpigmented epithelium at the beginning of the ciliary process after repeated instillation of 0.1% cyclosporin A eye drops, although there was a difference in miosis and anterior chamber inflammation-like reaction in individual monkeys.
authors.affiliation: Department of Ophthalmology, National Defense Medical College, Japan.
authors.forename: Shigenori
authors.initials: S
authors.lastname: Takagi
authors.forename: Shigekuni
authors.initials: S
authors.lastname: Okisaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizukawa
authors.forename: Shinpei
authors.initials: S
authors.lastname: Nishikawa
mesh_terms: D000818:Animals; D000867:Anterior Chamber; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D000882:Haplorhini; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D015877:Miosis / Q000139:chemically induced*; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000009:adverse effects; D011817:Rabbits
chemical_list: D009883:Ophthalmic Solutions; D016572:Cyclosporine