Emerging roles of beta-arrestins.
Arrestins were originally characterized as structural adaptor proteins which modulate the desensitization and trafficking of seven-membrane-spanning receptors. From these seminal observations a multitude of novel functions for this gene family have arisen. Here we review the recently identified roles for beta-arrestin including its nuclear function and roles in development, cellular migration, and metastasis.
Buchanan
F Gregory
FG
The Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6838, USA.
DuBois
Raymond N
RN
D000818:Animals; D019390:Arrestins / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics; D011494:Protein Kinases / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism; D000071557:beta-Arrestins
D019390:Arrestins; D043562:Receptors, G-Protein-Coupled; D051153:Wnt Proteins; D000071557:beta-Arrestins; D011494:Protein Kinases