title: [A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient].
abstract: A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/microl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.
authors.affiliation: Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kubota
authors.forename: Chizuru
authors.initials: C
authors.lastname: Takishima
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Ishii
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kawamura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Itsui
authors.forename: Eriko
authors.initials: E
authors.lastname: Okada
authors.forename: Seishin
authors.initials: S
authors.lastname: Chin
authors.forename: Shinya
authors.initials: S
authors.lastname: Oooka
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Akihiro
authors.initials: A
authors.lastname: Araki
authors.forename: Naoya
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Miyata
authors.forename: Takanori
authors.initials: T
authors.lastname: Kanai
authors.forename: Mamoru
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000038:Abscess / Q000209:etiology; D000328:Adult; D001004:Anus Diseases / Q000209:etiology; D001853:Bone Marrow / Q000187:drug effects*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007079:Ileitis / Q000209:etiology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007958:Leukocyte Count; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects*; D019804:Mesalamine / Q000008:administration & dosage; D009503:Neutropenia / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents; D016179:Granulocyte Colony-Stimulating Factor; D019804:Mesalamine; D015122:Mercaptopurine