Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators.
A novel series of hydantoin derivatives were identified by in vivo studies as tissue selective androgen receptor modulators. SAR around this series revealed that the function of the ligand could be altered by minor structural modification.
Zhang
Xuqing
X
Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA. xzhang5@prdus.jnj.com
Allan
George F
GF
Sbriscia
Tifanie
T
Linton
Olivia
O
Lundeen
Scott G
SG
Sui
Zhihua
Z
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000726:Androgen Antagonists; D006827:Hydantoins; D011944:Receptors, Androgen