title: Inductin of neuron-derived orphan receptor-1 in the dentate gyrus of the hippocampal formation following transient global ischemia in the rat.
abstract: Neuron-derived orphan receptor (NOR-1) is a member of the thyroid/steroid receptor superfamily that was originally identified in forebrain neuronal cells undergoing apoptosis. In addition to apoptotic stimuli, activation of several signal transduction pathways including direct neuronal depolarization regulates the expression of NOR-1. In this study we tested whether the expression of NOR-1 is changed following transient ischemic injury in the adult rat brain. NOR-1 mRNA increased rapidly in the dentate gyrus of the hippocampal formation and piriform cortex 3 h after transient global ischemia and returned to basal level at 6 h. On the other hand, oxygen-glucose deprivation of cultured cerebral cortical neurons did not alter the expression of NOR-1. These results suggest that expression of NOR-1 is differentially regulated in different brain regions in response to globally applied brain ischemia, but that hypoxia is not sufficient to induce its expression.
authors.affiliation: Department of Anatomy and Division of Brain Korea 21 Biomedical Science, College of Medicine, Korea University, Seoul 136-701, Korea.
authors.forename: Younghwa
authors.initials: Y
authors.lastname: Kim
authors.forename: Soontaek
authors.initials: S
authors.lastname: Hong
authors.forename: Mi Ra
authors.initials: MR
authors.lastname: Noh
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Pil Woo
authors.initials: PW
authors.lastname: Huh
authors.forename: Sun-Hwa
authors.initials: SH
authors.lastname: Park
authors.forename: Woong
authors.initials: W
authors.lastname: Sun
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D018891:Dentate Gyrus / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction
chemical_list: D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C091333:Nr4a3 protein, rat; D016760:Proto-Oncogene Proteins c-fos