title: The spontaneously diabetic Torii rat with gastroenteropathy.
abstract: The spontaneously diabetic Torii (SDT) rat was recently recognized as a new animal model of non-obese type 2 diabetes. As the severe diabetic ocular complications seen in SDT rats already have been investigated, we examined another common diabetic complication, gastroenteropathy. Male SDT rats developed diabetes at 20 weeks and diarrhea at 28 weeks of age. Gastrointestinal motility was evaluated at 28 weeks by measuring the distance of small intestinal transit by oral administration of the non-absorbed marker, arabic gum. SDT rats exhibited greater intestinal transit distance than control SD rats (54.1+/-2.6% versus 43.0+/-1.2%). Insulin treatment of SDT rats begun at 20 weeks of age produced improved stool and reduced intestinal transit distance (41.4+/-0.3%). Morphologically, the SDT rats exhibited longer villi and heavier weight of intestine compared to control SD rats. These results suggest that the SDT rat may be a useful animal model for studies of diabetic gastroenteropathy.
authors.affiliation: Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Yamada
authors.forename: Masaya
authors.initials: M
authors.lastname: Hosokawa
authors.forename: Shimpei
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Nagashima
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Fukuda
authors.forename: Hideya
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ogawa
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Fujita
authors.forename: Naoya
authors.initials: N
authors.lastname: Ueda
authors.forename: Futoshi
authors.initials: F
authors.lastname: Matsuyama
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
authors.forename: Nobuya
authors.initials: N
authors.lastname: Inagaki
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D049628:Body Size; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005243:Feces / Q000737:chemistry; D005753:Gastric Mucosa / Q000033:anatomy & histology / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000503:physiopathology*; D005769:Gastrointestinal Motility; D007413:Intestinal Mucosa / Q000033:anatomy & histology / Q000503:physiopathology; D007421:Intestine, Small / Q000033:anatomy & histology / Q000503:physiopathology; D008055:Lipids / Q000032:analysis; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000033:anatomy & histology / Q000503:physiopathology
chemical_list: D001786:Blood Glucose; D008055:Lipids