title: Is digoxin a drug of the past?
abstract: Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.
authors.affiliation: Department of Medicine, Michigan State University, East Lansing 44824, USA. mohammad.pervaiz@ht.msu.edu
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Pervaiz
authors.forename: Michael G
authors.initials: MG
authors.lastname: Dickinson
authors.forename: Mohamad
authors.initials: M
authors.lastname: Yamani
mesh_terms: D001281:Atrial Fibrillation / Q000188:drug therapy; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004077:Digoxin / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans
chemical_list: D002316:Cardiotonic Agents; D004077:Digoxin