Early proteinuria is a strong indicator of donor renal lesions, ischemia-reperfusion injury and immunological aggression.
BACKGROUND
Early proteinuria is associated with reduced long-term graft survival. However, the determinants and mechanisms of proteinuria early after transplantation have not been identified.


METHODS
Parameters associated with proteinuria within the first 3 months following transplantation were retrospectively assessed among 484 renal transplant recipients.


RESULTS
Proteinuria was more abundant in patients with a history of two or more rejection episodes (0.42 +/- 0.68 vs 0.18 +/- 0.39 g/d; P = .02). Proteinuria was greater when donor age was 60 or more (OR: 4.43; P = .003), when recipient death was due to cardiovascular causes (OR: 1.98; P = .002), or when cold (OR: 1.77; P = .006) or warm (1.21; P = .09) ischemia times were prolonged.


CONCLUSIONS
Proteinuria early after transplantation was related to pretransplant renal lesions, ischemia-reperfusion, and immunologic injuries.
Halimi
J
J
François Rabelais University, Department of Nephrology and Clinical Immunology, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours cedex 9, France. halimi@med.univ-tours.fr
Laouad
I
I
Buchler
M
M
Al-Najjar
A
A
Chatelet
V
V
Houssaini
T S
TS
Nivet
H
H
Lebranchu
Y
Y
D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000097:blood; D006801:Humans; D007154:Immune System Diseases / Q000652:urine*; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology*; D015427:Reperfusion Injury / Q000652:urine*
D015415:Biomarkers; D003404:Creatinine