Reverse-genetic approaches to the study of Borna disease virus.
Borna disease virus (BDV) is an enveloped virus that has a non-segmented, negative-strand RNA genome with the characteristic organization of the mononegaviruses. However, based on its unique genetic and biological features, BDV is considered to be the prototypic member of a new mononegavirus family, the Bornaviridae. BDV causes central nervous system (CNS) disease in a wide variety of mammals. This article discusses the recently developed reverse-genetics systems for BDV, and the implications for the elucidation of the molecular mechanisms underlying BDV-host interactions, including the basis of BDV persistence in the CNS and its associated diseases.
de la Torre
Juan C
JC
Molecular Integrative Neuroscience Department IMM-6, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. juanct@scripps.edu
D000818:Animals; D001891:Borna disease virus / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology*; D005821:Genetic Techniques; D016679:Genome, Viral; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics; D014779:Virus Replication / Q000235:genetics / Q000502:physiology
D012367:RNA, Viral; D014764:Viral Proteins