Vascular update: morphogenesis, tumors, malformations, and molecular dimensions.
This vascular review is organized under the following headings: vasculogenesis and angiogenesis; vascular endothelial growth factors, their receptors, TIE receptors, and angiopoietins; other factors in blood vessel formation; parallel patterning in blood vessels and nerves; physiological and pathological neovascularization; the role of VEGF receptors in metastasis; anti-angiogenic therapy for tumors; association of blood vessels with fat; vascular malformations and vascular tumors; infantile hemangiomas; congenital hemangiomas; lymphatic malformations; molecular characteristics of some disorders with vascular malformations; Kasabach-Merritt phenomenon; Sturge-Weber syndrome, Klippel-Trenaunay syndrome, and Parkes Weber syndrome; diagnostic and laboratory studies; and future perspectives.
Cohen
M Michael
MM
Department of Pediatrics, Dalhousie University, 5981 University Ave., Halifax, Nova Scotia B3H 1W2. michael.cohen@dal.ca
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001808:Blood Vessels / Q000002:abnormalities* / Q000254:growth & development* / Q000502:physiology; D002648:Child; D005260:Female; D006801:Humans; D042601:Lymphatic Vessels / Q000002:abnormalities; D008297:Male; D009024:Morphogenesis; D009383:Neoplasms, Vascular Tissue / Q000151:congenital / Q000188:drug therapy / Q000209:etiology*; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D040262:Receptors, Vascular Endothelial Growth Factor / Q000502:physiology; D013577:Syndrome; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor