title: Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease.
abstract: Patients with Parkinson's disease frequently have mild to moderate depression and exhibit low hedonic tone. The authors investigate the impact of a single L-dopa challenge and the acute effects of electric stimulation of the subthalamic nucleus (STN) on symptoms of depression and hedonic tone. Depressive symptoms improved with L-dopa and STN stimulation to the same extent. However, hedonic tone improved only with L-dopa. Most of the emotional changes did not correlate with changes in motor performance, indicating they were not just reactive but specific to the treatment. These results demonstrate a single dissociation of depressive symptoms and anhedonia in response to an acute L-dopa and STN-stimulation challenge.
authors.affiliation: Department of Neurology, University Schleswig-Holstein, Kiel, Germany. k.witt@neurologie.uni-kiel.de
authors.forename: Karsten
authors.initials: K
authors.lastname: Witt
authors.forename: Christine
authors.initials: C
authors.lastname: Daniels
authors.forename: Jan
authors.initials: J
authors.lastname: Herzog
authors.forename: Delia
authors.initials: D
authors.lastname: Lorenz
authors.forename: Jens
authors.initials: J
authors.lastname: Volkmann
authors.forename: Julia
authors.initials: J
authors.lastname: Reiff
authors.forename: Maximilian
authors.initials: M
authors.lastname: Mehdorn
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
authors.forename: Paul
authors.initials: P
authors.lastname: Krack
mesh_terms: D000339:Affect / Q000502:physiology; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D003071:Cognition / Q000502:physiology; D046690:Deep Brain Stimulation; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy*; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009068:Movement; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D020531:Subthalamic Nucleus / Q000502:physiology*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa