title: Characteristics of bicalutamide solid dispersions and improvement of the dissolution.
abstract: The purpose of our study was to formulate and evaluate bicalutamide (BL) solid dispersions (SD). The physicochemical properties were evaluated by differential scanning calorimetry (DSC), Fourier-Transform infrared (FT-IR) spectroscopy, Powder X-ray diffractometry (PXRD), dissolution studies, and stability studies. The dissolution studies demonstrated that the dissolution of BL from BL-SD increased with an increase in carrier content (PVP K30). X-ray assays and DSC results both confirmed the amorphous state of BL in BL-SD. Stability studies conducted after 6 months showed that BL exhibited excellent stability in the solid dispersion of PVP K30 (1:5).
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry and Pharmaceutics, East China University of Science and Technology, Shanghai, 200237, China.
authors.forename: Fuzheng
authors.initials: F
authors.lastname: Ren
authors.forename: Qiufang
authors.initials: Q
authors.lastname: Jing
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Tang
authors.forename: Yongjia
authors.initials: Y
authors.lastname: Shen
authors.forename: Jialei
authors.initials: J
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Jingbin
authors.initials: J
authors.lastname: Cui
mesh_terms: D000813:Anilides / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D004355:Drug Stability; D009570:Nitriles; D011145:Polyvinyls / Q000008:administration & dosage*; D011208:Powders; D011759:Pyrrolidines / Q000008:administration & dosage*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014105:Tosyl Compounds; D014961:X-Ray Diffraction
chemical_list: D000813:Anilides; D004337:Drug Carriers; D009570:Nitriles; D011145:Polyvinyls; D011208:Powders; D011759:Pyrrolidines; D014105:Tosyl Compounds; C505150:poly(N-vinylpyrrolidine); C053541:bicalutamide