title: The effect of aromatase inhibitor, fadrozole, on sGnRHa stimulated LH secretion in goldfish (Carassius auratus) and common carp (Cyprinus carpio).
abstract: The aromatase inhibitor, fadrozole, was applied to common carp and goldfish in order to examine its ability to increase the spontaneous and sGnRHa stimulated LH secretion. First, trials in goldfish in 2003 showed fadrozole's moderate ability to potentiate sGnRHa-stimulated LH secretion. However, this ability was much weaker than that obtained with dopamine antagonist, pimozide. There was no ovulation in fadrozole-treated fish. Several experiments on goldfish and carp during the two consecutive years with the different treatment regimes and doses of fadrozole did not confirm the optimistic results obtained in 2003. This shows that fadrozole is unable to replace the antidopaminergic drugs being used in fisheries practice.
authors.affiliation: Department of Ichthyobiology and Fisheries, University of Agriculture, Kraków, Poland. tmikolaj@ar.krakow.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Mikolajczyk
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Chyb
authors.forename: Miroslawa
authors.initials: M
authors.lastname: Sokolowska-Mikolajczyk
authors.forename: Pawel
authors.initials: P
authors.lastname: Szczerbik
authors.forename: Magdalena
authors.initials: M
authors.lastname: Socha
authors.forename: Piotr
authors.initials: P
authors.lastname: Epler
mesh_terms: D000818:Animals; D047072:Aromatase Inhibitors / Q000494:pharmacology*; D017316:Fadrozole / Q000494:pharmacology*; D006054:Goldfish / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives; D007986:Luteinizing Hormone / Q000187:drug effects*
chemical_list: D047072:Aromatase Inhibitors; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D017316:Fadrozole