[Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury].
OBJECTIVE
To explore the relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury.


METHODS
In 1:1 case-control study, 113 abnormal chromosome workers exposed to ionizing radiation were selected as cases and 113 normal chromosome as controls who matched with case for sex, age (+/- 5 years), nation, type of work, the same or more but in 2 years work length and the same similar levels of the cumulative exposure radiation dose. Genotypes were analysed using PCR based restriction fragment length polymorphism techniques.


RESULTS
The frequency of XRCC1 26304TT allele in case group (18.58%) was significantly higher than that in control group (7.08%), with OR for radiation damage being 3.47 (95% CI 1.43 - 8.44, P < 0.05). No association was observed between XRCC1 G27466A and G28152A and susceptibility to radiation injury.


CONCLUSIONS
The mutation of XRCC1 C26304T is related with the susceptibility to radiation injury. The polymorphisms of XRCC1 G27466A and G28152A are not found to have association with abnormal chromosomes.
Wang
Liang-qun
LQ
Tangshan Center for Disease Control and Prevention, Tangshan, Hebei province 063000, China.
Wu
Xu-mei
XM
Fan
Xue-yun
XY
Yan
Jin-de
JD
Bai
Yu-ping
YP
Li
Ru-li
RL
D000328:Adult; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011832:Radiation Injuries / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human