title: Thyroid function and morphology after a successful kidney transplantation.
abstract: Although thyroid disorders related to the end-stage renal disease (ESRD) are well known, there are discordant data on the function and morphology of the thyroid gland after renal transplantation (RT). The objective of this cross-sectional, case-control study was to investigate the prevalence and risk factors for disorders in the thyroid function and morphology after a successful RT. Fifty consecutive patients (25 females, 25 males) with fully functioning allograft were enrolled. Their age at transplant ranged from 23 to 44 yr (median, 38) and their post-RT follow-up lasted 15-86 months (median, 23). One hundred healthy subjects matched for sex, age and body mass index (BMI) were included as controls. Serum free thyroid hormones, TSH, thyroglobulin, thyroid hormone-binding globulin (TBG) and iodine urinary excretion were determined; ultrasonographic exam of the thyroid gland was performed in all subjects. Age, gender, time elapsed from RT, dialysis duration, kidney function, type of immunosuppression and corticosteroid dose were considered as possible influencing factors for the thyroid function. Hypothyroidism was found in 6% of patients, "low T3 syndrome" in 52%, while another 26% had free T3 (FT3), free T4 (FT4) and TSH in the lowest third of the normal range, suggesting inhibition of the whole hypothalamic-pituitary-thyroid (HPT) axis. Iodine excretion and prevalence of anti-thyroid antibodies were similar in both patients and controls. There was no significant difference in the thyroid function according to different immunosuppressive regimens. In patients, an ultrasonographic exam revealed a very variable thyroid volume ranging from 7.2 to 24.8 ml. Solid nodules were detected in 12 (24%) cases and cystic lesions in another four (8%); they were proven negative at cytological examination. Dialysis duration was longer in patients with thyroid nodules than in those without (p<0.05). Inhomogeneous hypoechoic pattern typical for chronic thyroiditis was more frequent than its biochemical expression. In conclusion, a high prevalence of abnormal thyroid morphology was found in patients after a successful RT, being partly related to a previous uremia. Abnormalities in the thyroid function are likely an expression of the post-transplant general and immunological conditions. Endocrinological follow-up is advisable in patients after RT, in order to discriminate thyroid dysfunctions which need specific treatments from those that can only be followed-up, avoiding inappropriate treatments of biochemical abnormalities.
authors.affiliation: Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, 80131 Naples, Italy. tauchman@unina.it
authors.forename: L
authors.initials: L
authors.lastname: Tauchmanovà
authors.forename: R
authors.initials: R
authors.lastname: Carrano
authors.forename: T
authors.initials: T
authors.lastname: Musella
authors.forename: F
authors.initials: F
authors.lastname: Orio
authors.forename: M
authors.initials: M
authors.lastname: Sabbatini
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
authors.forename: G
authors.initials: G
authors.lastname: Fenzi
authors.forename: S
authors.initials: S
authors.lastname: Federico
authors.forename: A
authors.initials: A
authors.lastname: Colao
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007453:Iodide Peroxidase / Q000276:immunology; D007455:Iodine / Q000652:urine; D033862:Iron-Binding Proteins / Q000276:immunology; D016030:Kidney Transplantation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012727:Sex Characteristics; D013954:Thyroglobulin / Q000097:blood / Q000276:immunology; D013959:Thyroid Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007166:Immunosuppressive Agents; D033862:Iron-Binding Proteins; D013963:Thyroid Hormones; D013972:Thyrotropin; D013954:Thyroglobulin; D007455:Iodine; C056658:TPO protein, human; D007453:Iodide Peroxidase