Serotonergic receptors in therapeutic approaches to gastrointestinal disorders.
Most of the cloned serotonin (5-HT) receptor subtypes are present on enteric neurons that control gastrointestinal function. Because of the wide distribution of 5-HT receptor subtypes in the gut, the precise actions of currently marketed drugs are unclear. Furthermore, efficacy of these drugs varies between individuals. Two recent advances provide important potential explanations for this phenomenon: polymorphisms have recently been discovered in the gene for the key enzyme in neural 5-HT production, and physiologically relevant 5-HT(4) receptor splice variants have been shown to be differentially located across intestinal regions. Functional 5-HT(7) receptors have recently been demonstrated in the gut and, together with the 5-HT(1A) receptor, offer new therapeutic options. In addition, recently suggested identities for the elusive 5-HT(1P) receptor could result in other, more effective therapeutic targets.
Neal
Kathleen Bronwyn
KB
Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Bornstein
Joel Charles
JC
D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D011985:Receptors, Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists