[Bone disease related to rheumatoid arthritis].
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressive bone destruction, in which proinflammatory cytokines such as tumor necrosis factor-alpha play essential roles. Recent studies have revealed an important involvement of osteoclasts in bone destruction of RA. In this review, I would like to explain the molecular mechanism of osteoclast development in RA, and propose the possibility of anti-osteoclast therapy to the disease.
Tanaka
Sakae
S
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000503:physiopathology; D016723:Bone Remodeling / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010024:Osteoporosis / Q000209:etiology*; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C505688:TNFSF11 protein, human