Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia.
The aim of this study was to investigate the relationship between the functional C957T single-nucleotide polymorphism of the dopamine D2 receptor (DRD2) gene and the risk for schizophrenia. We therefore conducted a case-control association study of 188 Finnish schizophrenia patients meeting the DSM-IV criteria and 384 healthy controls. The 5' nuclease assay (TaqMan) was used to determine genotypes. A greater proportion of patients with schizophrenia than healthy controls were C-allele carriers (odds ratio 1.5, 95% confidence interval (CI) 1.0-2.3, P=0.05). Our results are in agreement with an earlier association study suggesting that the C957T C-allele plays a role in the genetic vulnerability for schizophrenia and support the involvement of the DRD2 gene in schizophrenia pathogenesis.
Hänninen
Kari
K
South Karelia Central Hospital, Department of Psychiatry, Lappeenranta, Finland. kari.hanninen@ekshp.fi
Katila
Heikki
H
Kampman
Olli
O
Anttila
Sami
S
Illi
Ari
A
Rontu
Riikka
R
Mattila
Kari M
KM
Hietala
Jarmo
J
Hurme
Mikko
M
Leinonen
Esa
E
Lehtimäki
Terho
T
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D044465:White People
D017448:Receptors, Dopamine D2