Studies of interactions among cobalt(III) polypyridyl complexes, 6-mercaptopurine and DNA.
The interactions between cobalt polypyridyl coordination compounds Co(L)(3)(3+)(L=1,10-phenanthroline(phen), and bipyridine(bpy)),6-mercaptopurine and calf thymus DNA have been investigated using electrochemical methods(cyclic voltammetry, differential pulse voltammetry), electronic absorption spectroscopy and viscosity measurements. Results indicate that there is an obvious interaction equilibrium between Co(L)(3)(3+), 6-mercaptopurine and DNA. The phenomena are investigated for the first time, and believed to be helpful to use the anticancer drugs more efficiently.
Zhou
Cuifeng
C
Reliability Research and Analysis Centre, Chinese Electronic Product Reliability and Environmental Testing Research Institute, Guangzhou 510610, PR China.
Du
Xusheng
X
Li
Hong
H
D003035:Cobalt / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D017097:Electric Impedance; D015122:Mercaptopurine / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011048:Polarography / Q000379:methods*
D009942:Organometallic Compounds; D003035:Cobalt; D004247:DNA; C427203:calf thymus DNA; D015122:Mercaptopurine