NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach.
The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population.
Healy
Daniel G
DG
Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom. d.healy@ion.ucl.ac.uk
Abou-Sleiman
Patrick M
PM
Ahmadi
Kourosh R
KR
Gandhi
Sonia
S
Muqit
Miratul M
MM
Bhatia
Kailash P
KP
Quinn
Niall P
NP
Lees
Andrew J
AJ
Holton
Janice L
JL
Revesz
Tamas
T
Wood
Nicholas W
NW
D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D010300:Parkinson Disease / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C539882:NR4A2 protein, human; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D014157:Transcription Factors