title: Evidence for biogeographic patterning of mitochondrial DNA sequences in Eastern horse populations.
abstract: Equine mitochondrial DNA (mtDNA) phylogeny reconstruction reveals a complex pattern of variation unlike that seen in other large domesticates. It is likely that this pattern reflects a process of multiple and repeated, although not necessarily independent, domestication events. Until now, no clear geographic affiliation of clades has been apparent. In this study, amova analyses have revealed a significant non-random distribution of the diversity among equine populations when seven newly sequenced Eurasian populations were examined in the context of previously published sequences. The association of Eastern mtDNA types in haplogroup F was highly significant using Fisher's exact test of independence (P = 0.00000). For the first time, clear biogeographic partitioning has been detected in equine mtDNA sequence.
authors.affiliation: Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: A
authors.initials: A
authors.lastname: McGahern
authors.forename: M A M
authors.initials: MA
authors.lastname: Bower
authors.forename: C J
authors.initials: CJ
authors.lastname: Edwards
authors.forename: P O
authors.initials: PO
authors.lastname: Brophy
authors.forename: G
authors.initials: G
authors.lastname: Sulimova
authors.forename: I
authors.initials: I
authors.lastname: Zakharov
authors.forename: M
authors.initials: M
authors.lastname: Vizuete-Forster
authors.forename: M
authors.initials: M
authors.lastname: Levine
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: D E
authors.initials: DE
authors.lastname: MacHugh
authors.forename: E W
authors.initials: EW
authors.lastname: Hill
mesh_terms: D000818:Animals; D001208:Asia; D004272:DNA, Mitochondrial / Q000737:chemistry*; D005060:Europe; D014644:Genetic Variation; D005843:Geography; D006239:Haplotypes; D006736:Horses / Q000235:genetics*; D010802:Phylogeny; D017422:Sequence Analysis, DNA
chemical_list: D004272:DNA, Mitochondrial