A common profile for polymer-based controlled releases and its logical interpretation to general release process.
The release of drug from a polymeric matrix is complicated. It often involves drug diffusion, interface movement and various interactions. It also shows a dependence on the length of polymer rod. With Lc as the 'critical length', three different phases can be distinguished from the kinetic process. Prior to reaching Lc, the interface movement plays a key role on determining the release. Otherwise, the drug diffusion can dominate the release process. Near Lc, however, both factors are involved. The rate of interface movement is closely associated with the time and position in the polymer rod. Taking these characters into account, a common model is presented in this article to be tentatively used to interpret the release process. These results provide preliminarily an insight into the understanding of controlled release process.
Li
Songjun
S
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China. Lsjchem@msn.com
Shen
Yan
Y
Li
Wuke
W
Hao
Xiao
X
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers