title: New insights into the regulatory mechanisms of the LuxR family of quorum sensing regulators.
abstract: Bacteria use small signal molecules, referred to as autoinducers, in order to monitor their population density and coordinate gene expression in a process named quorum sensing. In Gram-negative bacteria, acylated homoserine lactones are the most common autoinducer used for cell-to-cell communication. Increasing evidence that many different functions are controlled by acylated homoserine lactone quorum sensing has stimulated intensive investigations into the physiology, molecular biology and biochemistry that underlie this process. Here we review our current understanding of the molecular mechanisms used by the transcriptional regulators responsive to acylated homoserine lactone autoinducers to control gene expression and the structural modifications induced by acylated homoserine lactones binding specifically on these regulators.
authors.affiliation: Unité de Microbiologie et Génétique, UMR CNRS-INSA-Université Lyon 1 5122, Domaine Scientifique de la Doua, 10 rue R. Dubois, bât A. Lwoff, 69622, Villeurbanne Cedex, France. William.nasser@insa-lyon.fr
authors.forename: William
authors.initials: W
authors.lastname: Nasser
authors.forename: Sylvie
authors.initials: S
authors.lastname: Reverchon
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D002450:Cell Communication; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D053038:Quorum Sensing; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors
chemical_list: D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C064778:LuxR autoinducer binding proteins; C088386:homoserine lactone; D015107:4-Butyrolactone