title: Quorum sensing-disrupting brominated furanones protect the gnotobiotic brine shrimp Artemia franciscana from pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates.
abstract: Autoinducer 2 (AI-2) quorum sensing was shown before to regulate the virulence of Vibrio harveyi towards the brine shrimp Artemia franciscana. In this study, several different pathogenic V. harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates were shown to produce AI-2. Furthermore, disruption of AI-2 quorum sensing by a natural and a synthetic brominated furanone protected gnotobiotic Artemia from the pathogenic isolates in in vivo challenge tests.
authors.affiliation: Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653, 9000 Ghent, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Defoirdt
authors.forename: Roselien
authors.initials: R
authors.lastname: Crab
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Wood
authors.forename: Patrick
authors.initials: P
authors.lastname: Sorgeloos
authors.forename: Willy
authors.initials: W
authors.lastname: Verstraete
authors.forename: Peter
authors.initials: P
authors.lastname: Bossier
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects / Q000382:microbiology*; D005663:Furans / Q000737:chemistry / Q000494:pharmacology; D005856:Germ-Free Life; D006714:Homoserine / Q000031:analogs & derivatives / Q000378:metabolism; D007783:Lactones / Q000378:metabolism; D013045:Species Specificity; D014733:Vibrio / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*; D014736:Vibrio parahaemolyticus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism / Q000472:pathogenicity*
chemical_list: D005663:Furans; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine