[New diagnostic tools in renal transplantation].
Renal transplantation is the best treatment available for end stage renal disease. The determination of human genome has profoundly modified the possible approaches of renal transplant recipient by allowing tailoring of immunosuppressive drugs and immunologic diagnosis. The aim of this review article is to determine the role of these various techniques during the different step before and after transplantation. Genotyping, transcriptome analysis, proteomic as well as the specific immune response are analyzed in this article.
Thervet
Eric
E
Service de transplantation rénale et de soins intensifs, hôpital Necker, 149, rue de Sèvres, 75015 Paris, France. eric.thervet@nck.ap-hop-paris.fr
Legendre
Christophe
C
D001706:Biopsy / Q000379:methods; D016207:Cytokines / Q000276:immunology; D006084:Graft Rejection / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000276:immunology; D020411:Oligonucleotide Array Sequence Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity
D016207:Cytokines; D006680:HLA Antigens; D007166:Immunosuppressive Agents