[Analysis of 92 ectopic pregnancy patients after in vitro fertilization and embryo transfer].
OBJECTIVE
To investigate the occurrence of ectopic pregnancy among women who received in vitro fertilization and assess the influential factors.


METHODS
The indications, methods of assisted conception and ectopic types were analyzed retrospectively after the patients received in vitro fertilization and embryo transfer (IVF-ET), intracytoplasmic sperm injection (ICSI), or freezing-thawing embryo transfer (FET).


RESULTS
A total of 6007 embryo transfers were performed, and 2322 (38.7%) clinical pregnancies were obtained. Ninety-four (4.05%) of them were ectopic pregnancies; and 92 were tubal pregnancies. The occurrence rate was 3.96%, which constituted 97.87% (92/94) of all ectopic pregnancies. There were 2 cases of other parts: one in abdominal cavity and the other in cornual pregnancy with the occurrence rate of 0.86%, constituting 2.32% (2/94). Twenty heterotopic pregnancies occurred (0.86%), constituting 21.28% (20/94). Among all ectopic pregnancies, the assisted conception of 86 cases was tubal pathology and/or pelvic adherence (91.49%), and 24 patients had a history of ectopic pregnancy (25.53%). The differences of clinical pregnancy rates between IVF-ET, ICSI and FET were not significant (P>0.05). The ectopic rate of IVF-ET group was significantly higher than that of ICSI or FET group (P<0.05), respectively. The ectopic rate in FET group was also higher than that in ICSI group (P<0.05).


CONCLUSIONS
The occurrence rate of ectopic pregnancy after IVF is higher than that of spontaneous pregnancy, and the main cause for ectopic pregnancy is the tubal pathological changes.
Xiao
Hong-mei
HM
Institute of Reproduction and Stem Cell Engineering, Central South University, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha 410078, China.
Gong
Fei
F
Mao
Zeng-hui
ZH
Zhang
Hong
H
Lu
Guang-xiu
GX
D000328:Adult; D002681:China / Q000453:epidemiology; D004624:Embryo Transfer / Q000009:adverse effects*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female; D008875:Middle Aged; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic