Allergic contact dermatitis caused by latanoprost ophthalmic solution.
OBJECTIVE
Latanoprost is a prostaglandin F2 alfa analog that lowers intraocular pressure by increasing uveoscleral outflow. Herein we describe two cases of allergic contact dermatitis (ACD) to latanoprost.


METHODS
A 69-year-old man with open-angle glaucoma developed erythematous erosive swelling of bilateral eyelids after 4 months of latanoprost therapy. An 84-year-old man with open-angle glaucoma had pruritic erythematous plaques on the bilateral lower eyelids after latanoprost therapy for 4 months.


RESULTS
In both cases, latanoprost was discontinued and the condition gradually resolved in 1 month. The eyelid lesions recurred in days upon latanoprost rechallenge, but subsided after cessation of rechallenge.


CONCLUSIONS
ACD should be suspected if patients on latanoprost therapy have pruritus, erythema, swelling, or erosions on the eyelids even when the symptoms appear after several months of therapy, especially in the elderly.
Lai
C-H
CH
Department of Ophthalmology, Chang Gung Memorial Hospital-Chiayi, 6 Sec.West, Chia-Pu Road, Putz, Chiayi 61363, Taiwan.
Lai
I-C
IC
Chi
C-C
CC
D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000503:physiopathology; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000503:physiopathology; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D000077338:Latanoprost; D008297:Male; D009883:Ophthalmic Solutions / Q000009:adverse effects; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost