title: Canadian Cardiovascular Society position statement--recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease.
abstract: Since the last publication of the recommendations for the management and treatment of dyslipidemia, new clinical trial data have emerged that support a more vigorous approach to lipid lowering in specific patient groups. The decision was made to update the lipid guidelines in collaboration with the Canadian Cardiovascular Society. A systematic electronic search of medical literature for original research consisting of blinded, randomized controlled trials was performed. Meta-analyses of studies of the efficacy and safety of lipid-lowering therapies, and of the predictive value of established and emerging risk factors were also reviewed. All recommendations are evidence-based, and have been reviewed in detail by primary and secondary review panels. Major changes include a lower low-density lipoprotein cholesterol (LDL-C) treatment target (lower than 2.0 mmol/L) for high-risk patients, a slightly higher intervention point for the initiation of drug therapy in most low-risk individuals (LDL-C of 5.0 mmol/L or a total cholesterol to high-density lipoprotein cholesterol ratio of 6.0) and recommendations regarding additional investigations of potential use in the further evaluation of coronary artery disease risk in subjects in the moderate-risk category.
authors.affiliation: University of Ottawa Heart Institute, Ottawa, Canada. rmcpherson@ottawaheart.ca
authors.forename: Ruth
authors.initials: R
authors.lastname: McPherson
authors.forename: Jiri
authors.initials: J
authors.lastname: Frohlich
authors.forename: George
authors.initials: G
authors.lastname: Fodor
authors.forename: Jacques
authors.initials: J
authors.lastname: Genest
authors.lastname: Canadian Cardiovascular Society
mesh_terms: D002170:Canada; D002309:Cardiology / Q000592:standards*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D012955:Societies, Medical