Sub-cutaneous phaeohyphomycosis caused by Cladophialophora devriesii in a United Kingdom resident.
An 83-year-old diabetic man receiving corticosteroids developed a forearm lesion. Histology confirmed the presence of a dematiaceous fungus, with associated granulomatous inflammation. Culture of a biopsy yielded fungal colonies with branching chains of single-celled, melanised, dry, sympodial conidia, which were identified as Cladophialophora devriesii on the basis of morphology and rDNA gene sequencing. To date, C. devriesii has been a relatively rare cause of human disease. To our knowledge, this is only the second case to be described, and the first report of infection in a UK resident.
Howard
S J
SJ
Regional Mycology Laboratory, Hope Hospital, Manchester, UK. showard@fs1.ho.man.ac.uk
Walker
S L
SL
Andrew
S M
SM
Borman
A M
AM
Johnson
E M
EM
Denning
D W
DW
D000369:Aged, 80 and over; D001203:Ascomycota / Q000235:genetics / Q000302:isolation & purification*; D004275:DNA, Ribosomal / Q000032:analysis / Q000235:genetics; D003881:Dermatomycoses / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D006113:United Kingdom
D004275:DNA, Ribosomal