Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy.
Following cerebral hemispherectomy, the corticospinal tract is believed to undergo reorganizational changes, which can induce enhanced function of the contralateral motor pathway and mediate partial recovery of motor function. The aim of this study was to use diffusion tensor imaging to investigate the effects of hemispherectomy on the corticospinal tract, with particular attention to the corticospinal tract contralateral to the resection. Diffusion tensor imaging would presumably detect microstructural abnormalities through quantitative measurements of the fiber tract integrity and orientation. Four patients with anatomic hemispherectomy and three patients with subtotal hemispherectomy were examined and compared with age-matched normal controls. Apparent diffusion coefficient and fractional anisotropy values were measured in regions along the corticospinal tract: internal capsule, cerebral peduncle, rostral pons, midpons, and caudal pons. None of the patients with anatomic hemispherectomy or subtotal hemispherectomy showed significant changes in either apparent diffusion coefficient or fractional anisotropy values in the corticospinal tract contralateral to the resected hemisphere, whereas increased apparent diffusion coefficient and decreased fractional anisotropy were observed in the ipsilateral rostral pons, midpons, and caudal pons of all patients with anatomic hemispherectomy, as well as in the ipsilateral cerebral peduncle of one patient with subtotal hemispherectomy. Increased apparent diffusion coefficient values were also noted in the ipsilateral internal capsule of the same patient. This study revealed no evidence of significant reinforcement of the contralateral corticospinal tract in patients with hemispherectomy, at least from diffusion tensor imaging measurements, but suggests that wallerian degeneration most likely occurs in the ipsilateral motor pathway.
Wakamoto
Hiroyuki
H
Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit 48201, USA.
Eluvathingal
Thomas J
TJ
Makki
Malek
M
Juhász
Csaba
C
Chugani
Harry T
HT
D000293:Adolescent; D016880:Anisotropy; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D004827:Epilepsy / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D005260:Female; D038421:Hemispherectomy; D006801:Humans; D007223:Infant; D008297:Male; D011712:Pyramidal Tracts / Q000378:metabolism / Q000473:pathology*