title: Associations between exposure to polycyclic aromatic hydrocarbons and temporal change of urinary 1-hydroxypyrene levels in Taiwanese coke-oven workers.
abstract: OBJECTIVE
  Our aim is to analyze the association between polycyclic aromatic hydrocarbon (PAH) exposure and the temporal change of urinary 1-hydroxypyrene (1-OHP).
  
  
  METHODS
  Two personal air samples, eight spot urine samples, and questionnaires were used to collect PAH exposure, urinary 1-OHP, demographic data, and environmental pollutants.
  
  
  RESULTS
  Topside-oven workers had significantly higher levels of PAH exposure and 1-OHP than side-oven workers. Urinary 1-OHP was a biomarker for PAH exposure. In topside-oven workers, the trend of 1-OHP increased sharply and reached the top in the sixth day after work and declined dramatically on days off. In side-oven workers, such a trend was not found, and those who smoked showed a slight increase in urinary 1-OHP levels on days off.
  
  
  CONCLUSIONS
  We suggest that the pattern of temporal change of urinary 1-OHP levels is different between topside-oven and side-oven workers.
authors.affiliation: Graduate Institute of Dental Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Ying-Chu
authors.initials: YC
authors.lastname: Lin
authors.forename: Chih-Hong
authors.initials: CH
authors.lastname: Pan
authors.forename: Chiou-Jong
authors.initials: CJ
authors.lastname: Chen
authors.forename: Kuen-Yuh
authors.initials: KY
authors.lastname: Wu
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Chang-Chien
authors.forename: Chi-Kung
authors.initials: CK
authors.lastname: Ho
authors.forename: Trong-Neng
authors.initials: TN
authors.lastname: Wu
authors.forename: Hong-Yi
authors.initials: HY
authors.lastname: Chuang
authors.forename: Hsien-Wen
authors.initials: HW
authors.lastname: Kuo
authors.forename: Ming-Tsang
authors.initials: MT
authors.lastname: Wu
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D003077:Coke; D006801:Humans; D016014:Linear Models; D008297:Male; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis*; D011721:Pyrenes / Q000378:metabolism*; D013624:Taiwan
chemical_list: D000395:Air Pollutants, Occupational; D003077:Coke; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C033146:1-hydroxypyrene