title: Fatal pulmonary embolism and fatal bleeding in cancer patients with venous thromboembolism: findings from the RIETE registry.
abstract: OBJECTIVE
  To examine the clinical characteristics and outcomes of cancer patients with venous thromboembolism (VTE) in order to identify factors that place these patients at an increased risk for fatal pulmonary embolism (PE) or fatal bleeding.
  
  
  METHODS
  Registro Informatizado de la Enfermedad Trombo Embólica (RIETE) is a prospective registry of consecutive patients with symptomatic, objectively confirmed, acute VTE.
  
  
  RESULTS
  Up to January 2006, a total of 14 391 patients with symptomatic acute VTE were enrolled in RIETE, of whom 2945 (20%) had cancer. During the 3-month follow-up period the frequency of fatal PE in cancer patients was 2.6%, and that of fatal bleeding 1.0%. These frequencies were significantly higher than in VTE patients without cancer (1.4% and 0.3%, respectively). In patients with cancer, abnormal renal function, metastatic disease, recent major bleeding and recent immobility for >or= 4 days (42% of the 108 patients who died from PE or bleeding had recent immobility) were factors independently associated with an increased risk for both fatal PE and fatal bleeding. In addition, PE diagnosis on admission was an independent risk factor for fatal PE, while body weight < 60 kg was an independent risk factor for fatal bleeding.
  
  
  CONCLUSIONS
  Both fatal PE and fatal bleeding are more common in cancer patients with VTE than in those patients without cancer. In cancer patients, abnormal renal function, metastatic disease, recent major bleeding and recent immobility for >or= 4 days are associated with an increased risk for both fatal PE and fatal bleeding.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. mmonreal.germanstrias@gencat.net
authors.forename: M
authors.initials: M
authors.lastname: Monreal
authors.forename: C
authors.initials: C
authors.lastname: Falgá
authors.forename: M
authors.initials: M
authors.lastname: Valdés
authors.forename: C
authors.initials: C
authors.lastname: Suárez
authors.forename: F
authors.initials: F
authors.lastname: Gabriel
authors.forename: C
authors.initials: C
authors.lastname: Tolosa
authors.forename: J
authors.initials: J
authors.lastname: Montes
mesh_terms: D000368:Aged; D005260:Female; D006470:Hemorrhage / Q000401:mortality*; D006801:Humans; D007103:Immobilization; D007674:Kidney Diseases; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000150:complications / Q000453:epidemiology / Q000401:mortality*; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000401:mortality*; D012042:Registries; D012307:Risk Factors; D020246:Venous Thrombosis / Q000150:complications / Q000453:epidemiology / Q000401:mortality*