title: MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia.
abstract: MLL/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Panagopoulos
authors.forename: Henrik
authors.initials: H
authors.lastname: Lilljebjörn
authors.forename: Bodil
authors.initials: B
authors.lastname: Strömbeck
authors.forename: Lars
authors.initials: L
authors.lastname: Hjorth
authors.forename: Tor
authors.initials: T
authors.lastname: Olofsson
authors.forename: Bertil
authors.initials: B
authors.lastname: Johansson
mesh_terms: D002880:Chromosomes, Human, Pair 11; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D007223:Infant; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C114909:GAS7 protein, human; C514234:MLL-GAS7 fusion protein; D009419:Nerve Tissue Proteins; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein