title: No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia.
abstract: Some serological and genetic studies have suggested that alterations in folate metabolism are associated with increased vulnerability to schizophrenia. In particular, these findings are most striking for the role of a putatively functional variant (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene. To test the hypothesis that the T allele and the TT genotype are risk factors for psychosis, we genotyped the C677T polymorphism in 206 participants with schizophrenia or schizoaffective disorder and 359 participants from a population control sample. Neither the T allele nor the TT genotype was associated with increased risk for schizophrenia. These results do not support a role for the C677T MTHFR variant in schizophrenia.
authors.affiliation: Department of Psychiatry, The University of Iowa, Psychiatry Research/MEB, Iowa City, IA 52242-1000, USA. robert-philibert@uiowa.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Philibert
authors.forename: Tracy
authors.initials: T
authors.lastname: Gunter
authors.forename: Nancy
authors.initials: N
authors.lastname: Hollenbeck
authors.forename: William J
authors.initials: WJ
authors.lastname: Adams
authors.forename: Phillip
authors.initials: P
authors.lastname: Bohle
authors.forename: Hans
authors.initials: H
authors.lastname: Packer
authors.forename: Harinder
authors.initials: H
authors.lastname: Sandhu
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)