title: [Cachexia in chronic cardiac disease. Ancient syndrome new idea?].
abstract: Cachexia has long been recognized as serious complication of chronic illness. Cardiac cachexia is a syndrome of generalised wasting which carries a poor prognosis of the chronic heart disease. Characteristic features of cachexia include the activation of the immune system associated with raised plasma concentriations of tumor necrosis factor alpha (TNF(alpha) and other plasma cytokines. Another crucial issue is muscle wasting through the ubiquitin proteasome pathway. The prevention or attenuation of disease related skeletal muscle degeneration has been a common goal in the treatment of cardiac cachexia.
authors.affiliation: Katedra i Klinika Kardiologii Slaskiej Akademii Medycznej.
authors.forename: Ewa
authors.initials: E
authors.lastname: Jastrezebska-Maj
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Mizia-Stec
authors.forename: Marta
authors.initials: M
authors.lastname: Kasprzyk
authors.forename: Michał
authors.initials: M
authors.lastname: Straczkowski
authors.forename: Mahdi
authors.initials: M
authors.lastname: Al-Jeabory
authors.forename: Krystyna
authors.initials: K
authors.lastname: Jastrzebska-Okoń
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Gasior
mesh_terms: D000818:Animals; D002100:Cachexia / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*; D006331:Heart Diseases / Q000150:complications* / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D009133:Muscular Atrophy / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D011379:Prognosis; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha