title: Tetralogy of Fallot, hypertrophic cardiomyopathy, and Down's syndrome: a rare and challenging combination.
abstract: A case of the combination of tetralogy of Fallot, hypertrophic cardiomyopathy, and Down's syndrome is reported here and is the first report on the combination of the 3 entities. Tetralogy of Fallot is often associated with chromosomal aberration, while hypertrophic cardiomyopathy associates with certain gene loci. Our experience with treating this patient, although ultimately unsuccessful, may provide useful information in any future cases.
authors.affiliation: Department of Pathology and Anatomical Sciences, University of Missouri-Columbia, One Hospital Drive, Columbia, MO 65212, USA. wheelery@health.missouri.edu
authors.forename: Yurong Y
authors.initials: YY
authors.lastname: Wheeler
authors.forename: Pierantonio
authors.initials: P
authors.lastname: Russo
authors.forename: Guy A
authors.initials: GA
authors.lastname: Carter
authors.forename: Zuhdi
authors.initials: Z
authors.lastname: Lababidi
authors.forename: Alan M
authors.initials: AM
authors.lastname: Luger
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000473:pathology*; D004314:Down Syndrome / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging / Q000473:pathology; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D007223:Infant; D008297:Male; D013771:Tetralogy of Fallot / Q000150:complications / Q000473:pathology*; D014463:Ultrasonography