title: Pleocytosis after hemopoietic stem cell transplantation.
abstract: Frequency and clinical significance of cerebrospinal fluid (CSF) pleocytosis in hemopoietic stem cell (HSC) transplantation were surveyed. Cyclosporine (CSA)- or tacrolimus (FK506)-based regimens were used as graft-vs-host disease (GVHD) prophylaxis in allogeneic HSC transplantation. CSF pleocytosis with or without neurologic symptoms was detected in 12 of 25 patients receiving allogeneic HSC transplants but in none of 11 patients receiving autologous HSC transplants. Of the 12 patients with CSF pleocytosis, only one patient developed leukoencephalopathy later. There was a correlation between CSF cell numbers and trough levels of CSA but not with those of FK506. In patients receiving allogeneic HSC transplants, CSF pleocytosis may be relatively common and may reflect neurologic damage associated with calcineurin inhibitors.
authors.affiliation: Division of Cell Therapy, Jichi Medical School Hospital, Minamikawachi-machi, Kawachi-gun, Tochigi-ken, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nagashima
authors.forename: Kazuo
authors.initials: K
authors.lastname: Muroi
authors.forename: Chizuru
authors.initials: C
authors.lastname: Kawano-Yamamoto
authors.forename: Takuji
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Raine
authors.initials: R
authors.lastname: Tatara
authors.forename: Akiko
authors.initials: A
authors.lastname: Meguro
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Yoko
authors.initials: Y
authors.lastname: Obara
authors.forename: Iekuni
authors.initials: I
authors.lastname: Oh
authors.forename: Satoru
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sato
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Masaki
authors.initials: M
authors.lastname: Toshima
authors.forename: Ken
authors.initials: K
authors.lastname: Ohmine
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Ozaki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takatoku
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nagai
authors.forename: Keiya
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000328:Adult; D002452:Cell Count; D002555:Cerebrospinal Fluid / Q000166:cytology*; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007964:Leukocytosis / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D011292:Premedication / Q000379:methods; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D016572:Cyclosporine; D016559:Tacrolimus