Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors.
Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.
Honda
Kenya
K
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Takaoka
Akinori
A
Taniguchi
Tadatsugu
T
D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000502:physiology*; D007370:Interferon Type I / Q000096:biosynthesis* / Q000235:genetics*; D015533:Transcriptional Activation
D050835:Interferon Regulatory Factors; D007370:Interferon Type I