title: The effect of valence on the ion-exchange process: theoretical and experimental aspects on compound binding/release.
abstract: The effect of valence of mobile counter-ions (extracting electrolytes), mobile co-ions, and drug-like compounds was evaluated on drug binding/release in ion-exchange fibers. The experimental results support the Donnan theory and suggest that incorporation of monovalent salicylic acid (SA) and divalent 5-hydroxyisophthalic acid (di-COOH) into the anion-exchange fibers was attained mainly as a result of electrostatic (ionic) interaction, with additional contribution of non-electrostatic interactions. Increasing the capacity of ion-exchanger increased the molar amount of compound loading. More efficient release of model anions was observed at increasing valence or concentration of the extracting counter-ion. Potency to release the compounds decreased in the order of citrate (-3) > sulfate (-2) > chloride (-1). The valence of co-ions (sodium (+1) vs. calcium (+2)) in the external solution had only a slight effect on the release. Due to dual site binding (two ionized carboxylate groups), the amount of di-COOH bound into the fibers was half of that of monovalent SA. Also the release was significantly reduced, as the electrostatic interaction was stronger in the case of divalent compound. Simulations on the effect of valence on the Donnan potential and theoretical modeling of the release efficiencies by the external ions supported successfully the conclusions above.
authors.affiliation: Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland. kaisa.hanninen@helsinki.fi
authors.forename: Kaisa R
authors.initials: KR
authors.lastname: Hänninen
authors.forename: Lasse S
authors.initials: LS
authors.lastname: Murtomäki
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Kaukonen
authors.forename: Jouni T
authors.initials: JT
authors.lastname: Hirvonen
mesh_terms: D000837:Anion Exchange Resins / Q000737:chemistry*; D001665:Binding Sites; D002118:Calcium / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D002852:Chromatography, Ion Exchange; D002951:Citrates / Q000737:chemistry; D003198:Computer Simulation; D004573:Electrolytes / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D009994:Osmolar Concentration; D010795:Phthalic Acids / Q000737:chemistry*; D020156:Salicylic Acid / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry; D012995:Solubility; D055672:Static Electricity; D013431:Sulfates / Q000737:chemistry
chemical_list: D000837:Anion Exchange Resins; D002712:Chlorides; D002951:Citrates; D004573:Electrolytes; D010795:Phthalic Acids; D013431:Sulfates; C037880:5-hydroxyisophthalic acid; D012964:Sodium; D020156:Salicylic Acid; D002118:Calcium