In vitro antifungal-drug susceptibilities of mycelial and yeast forms of Penicillium marneffei isolates in Cambodia.
Penicillium marneffei infection is an important disease among human immunodeficiency virus patients in Southeast Asia. The in vitro antifungal-drug susceptibilities of 29 clinical isolates and 5 isolates from bamboo rats collected from 2002 to 2004 were determined. The P. marneffei yeast form is more susceptible than the mycelial form to amphotericin B and ketoconazole, while the mycelial and yeast forms displayed similar susceptibilities to flucytosine and itraconazole. The MICs of fluconazole were higher for both mycelial and yeast forms.
Sar
Borann
B
Laboratory of Medical Microbiology, Unit of Clinical Testing, Institut Pasteur du Cambodge, 5 Boulevard Monivong, BP 983, Phnom Penh, Cambodia. sborann@pasteur-kh.org
Boy
Sambo
S
Keo
Chantary
C
Ngeth
Chan Chhaya
CC
Prak
Narom
N
Vann
Mich
M
Monchy
Didier
D
Sarthou
Jean Louis
JL
D000935:Antifungal Agents / Q000494:pharmacology*; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D025282:Mycelium / Q000187:drug effects*; D010407:Penicillium / Q000187:drug effects*
D000935:Antifungal Agents; D017964:Itraconazole