title: Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever.
abstract: In a study comparing the virus load and immune reaction between patients with primary and secondary dengue-2 (DEN-2) infections in a hospital-based analysis, we found that 40.7% (55/135) of the 135 patients had secondary DEN-2 infection following a DEN-2 outbreak in southern Taiwan. Most of the secondary infections had subclinical primary dengue infections (78.2%; 43/55). Patients with secondary DEN-2 infections had lower platelet counts, and blood interferon-alpha and virus load, but significantly higher interleukin-10 (P=0.030) and anti-DEN-1 neutralization titers (P=0.013) than those with primary infection. Patients with secondary DEN-2 infection also had a higher rate of dengue hemorrhagic fever (DHF) (61.7% vs. 36.3%). A previous subclinical dengue infection is involved in the secondary DEN-2 infection associated with altered immune reaction and higher DHF rate, but lower blood virus load.
authors.affiliation: Department of Medical Research, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University College of Medicine, Niau-Sung, Kaohsiung, Taiwan.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Yeh
authors.forename: Rong-Fu
authors.initials: RF
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Jien-Wei
authors.initials: JW
authors.lastname: Liu
authors.forename: Men-Fang
authors.initials: MF
authors.lastname: Shaio
authors.forename: Kuender D
authors.initials: KD
authors.lastname: Yang
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D016207:Cytokines / Q000097:blood; D003715:Dengue / Q000453:epidemiology / Q000209:etiology / Q000276:immunology* / Q000821:virology; D003716:Dengue Virus / Q000145:classification / Q000276:immunology* / Q000502:physiology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D019595:Severe Dengue / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D013624:Taiwan / Q000453:epidemiology; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D016753:Interleukin-10