title: Substance misuse in first-episode psychosis: 15-month prospective follow-up study.
abstract: BACKGROUND
  Well-designed prospective studies of substance misuse in first-episode psychosis can improve our understanding of the risks associated with comorbid substance misuse and psychosis.
  
  
  OBJECTIVE
  To examine the potential effects of substance misuse on in-patient admission and remission and relapse of positive symptoms in first-episode psychosis.
  
  
  METHODS
  The study was a prospective 15-month follow-up investigation of 103 patients with first-episode psychosis recruited from three mental health services.
  
  
  RESULTS
  Substance misuse was independently associated with increased risk of in-patient admission, relapse of positive symptoms and shorter time to relapse of positive symptoms after controlling for potential confounding factors. Substance misuse was not associated with remission or time to remission of positive symptoms. Heavy substance misuse was associated with increased risk of in-patient admission, relapse and shorter time to relapse.
  
  
  CONCLUSIONS
  Substance misuse is an independent risk factor for a problematic recovery from first-episode psychosis.
authors.affiliation: ORYGEN Youth Health and Department of Psychiatry, University of Melbourne, Parkville, and Department of Medicine, University of Melbourne at St Vincent's Hospital, Fitzroy, Victoria, Australia. dwade@unimelb.edu.au
authors.forename: D
authors.initials: D
authors.lastname: Wade
authors.forename: S
authors.initials: S
authors.lastname: Harrigan
authors.forename: J
authors.initials: J
authors.lastname: Edwards
authors.forename: P M
authors.initials: PM
authors.lastname: Burgess
authors.forename: G
authors.initials: G
authors.lastname: Whelan
authors.forename: P D
authors.initials: PD
authors.lastname: McGorry
mesh_terms: D000328:Adult; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000209:etiology*; D012008:Recurrence; D012044:Regression Analysis; D012074:Remission Induction; D019966:Substance-Related Disorders / Q000523:psychology*; D016019:Survival Analysis; D013997:Time Factors