title: Synthesis and antihyperlipidemic activity of novel glycosyl fructose derivatives.
abstract: A series of novel di and trisaccharide derivatives containing d-fructose moiety at the reducing end have been synthesized and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model. Among 11 glycosyl fructose derivatives five compounds showed potent antihyperlipidemic activity either by enhancing high-density lipoprotein (HDL) cholesterol concentration and/or lowering triglyceride (TG) level.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Tiwari
authors.forename: Anju
authors.initials: A
authors.lastname: Puri
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chander
authors.forename: Geetika
authors.initials: G
authors.lastname: Bhatia
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Misra
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D006224:Cricetinae; D005632:Fructose / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D006031:Glycosylation; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D000960:Hypolipidemic Agents; D005632:Fructose