title: Biocompatibility of resin-based dental materials applied as liners in deep cavities prepared in human teeth.
abstract: BACKGROUND
  Since only a few data have been published concerning the effects of resinous dental materials on the pulp-dentin complex, the aim of this study was to evaluate the biocompatibility of resin-based materials applied as liners in deep cavities prepared in human teeth.
  
  
  METHODS
  After preparing class V cavities, the following dental materials were applied on the axial walls: group 1, Vitrebond (VIT; 3M ESPE); group 2, Ultra-Blend Plus (UBP; Untradent); and group 3, Clearfil SE Bond (CSEB; Kuraray). In group 4 (control), the hard-setting calcium hydroxide cement Dycal (CH; Caulk/Dentsply) was used. The teeth extracted at 7 days or between 30 and 85 days after the clinical procedures were processed for histological evaluation.
  
  
  RESULTS
  For all the experimental and control groups, most of specimens exhibited no pulpal response or slight inflammatory reaction associated with slight tissue disorganization at 7-day period. Moderate inflammatory pulpal response occurred only in one tooth (RDT = 262 microm) of group 3 in which transdentinal diffusion of resin components was observed.
  
  
  CONCLUSIONS
  The resin-based dental cements VIT and UBP as well as the bonding agent CSEB presented acceptable biocompatibility when applied in deep cavities prepared in sound human teeth.
authors.affiliation: Araraquara School of Dentistry, University of São Paulo State-UNESP, Rua Humaitá, 1680 CEP: 14.801-903, CP: 331, Araraquara, São Paulo, Brazil. casouzac@foar.unesp.br
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: de Souza Costa
authors.forename: Hilcia Mezzalira
authors.initials: HM
authors.lastname: Teixeira
authors.forename: Alexandre Batista
authors.initials: AB
authors.lastname: Lopes do Nascimento
authors.forename: Josimeri
authors.initials: J
authors.lastname: Hebling
mesh_terms: D000293:Adolescent; D001672:Biocompatible Materials / Q000009:adverse effects*; D002648:Child; D003736:Dental Cavity Lining / Q000379:methods*; D003764:Dental Materials / Q000009:adverse effects*; D006801:Humans; D008422:Materials Testing; D019279:Resin Cements / Q000009:adverse effects*; D014070:Tooth / Q000166:cytology / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D003764:Dental Materials; D019279:Resin Cements