Molecular epidemiology of adenovirus isolates from patients diagnosed with intussusception in Melbourne, Australia.
Twenty-one intussusception (IS)-associated and 59 temporally linked adenoviral isolates from clinical infections were compared. Species C (15/21 IS- and 32/59 non-IS-associated isolates) dominated. Of these, serotype 2 (AdV-2) (7/15 IS-associated isolates) and serotype 1 (AdV-1) (16/32 non-IS-associated isolates) were the most commonly identified serotypes. DNA restriction analysis of AdV-2 isolates identified six genomic types; of these, type D2 (3/7 IS- and 8/11 non-IS-associated isolates) was the dominant type after BamHI and SmaI digestion. IS-associated isolates are similar to circulating non-IS-associated strains.
Selvaraj
Gowri
G
Enteric Virus Group, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Vicotria 3052, Australia.
Kirkwood
Carl
C
Bines
Julie
J
Buttery
Jim
J
D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics*; D001315:Australia / Q000453:epidemiology; D002675:Child, Preschool; D015245:Deoxyribonuclease BamHI / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D006801:Humans; D007223:Infant; D007443:Intussusception / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D017720:Molecular Epidemiology
D015245:Deoxyribonuclease BamHI; C025651:CCCGGG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific