Fourier-domain biophotoacoustic subsurface depth selective amplitude and phase imaging of turbid phantoms and biological tissue.
A novel photothermoacoustic imaging modality utilizing a frequency-swept (chirped) intensity-modulated laser source and coherent frequency domain signal processing ("biophotoacoustics") was introduced for noninvasive imaging of biological tissues. The developed frequency-domain imaging system takes advantage of linear frequency modulation waveforms to relate depth of tissue chromophores to the frequency spectrum of the detected acoustic response and of a narrow signal detection bandwidth to improve signal-to-noise ratio (SNR). Application of frequency-domain photothermoacoustic (FD-PTA) imaging was demonstrated using turbid phantoms and ex-vivo specimens of chicken breast with embedded absorbing inclusions simulating tumors.
Telenkov
Sergey A
SA
Center for Advanced Diffusion-Wave Technologies University of Toronto Department of Mechanical and Industrial Engineering Toronto, Ontario, M5S 3G8 Canada.
Mandelis
Andreas
A
D000162:Acoustics; D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis*; D002645:Chickens; D005240:Feasibility Studies; D005583:Fourier Analysis; D007259:Infrared Rays; D007834:Lasers; D008858:Microscopy, Phase-Contrast / Q000295:instrumentation / Q000379:methods*; D009391:Nephelometry and Turbidimetry / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*