[The development of rapid screening of colorectal cancer by mutation detection in fecal DNA].
Colorectal cancer is one of the leading causes of death in the world. Screening high-risk populations for colorectal cancer can lower both the incidence of and deaths from the disease. Mutation detection in fecal DNA is a new approach of screening patients for colorectal cancer. Compared with colonoscopy and fecal occult-blood test, this approach has the advantages of high specificity, high sensitivity and general acceptability. This paper systematically reviewed genes associated with fecal DNA testing, methods for extracting tumor-specific DNA, and methods for detecting gene mutations. Moreover, the application of mutation detection using fecal DNA for rapid screening of colorectal cancer was briefly discussed.
Wu
Wen-Juan
WJ
College of Life Science and Technology, China Pharmaceutical University, Nanjing, China. wenjuanw@126.com
Zhang
Xin-Quan
XQ
D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods*; D005243:Feces; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D013997:Time Factors
D005819:Genetic Markers