Pharmacological properties of traditional medicine (XXXII): protective effects of hangeshashinto and the combinations of its major constituents on gastric lesions in rats.
The protective effect of Hangeshashinto (HST) and its major constituents, baicalin (BA), berberine (BE), saponin fraction of ginseng (GS) and glycyrrhizin (GL) on rat gastric lesion induced by ethanol was examined to clarify its active ingredients and action mechanism. Oral treatment with HST at the doses of 125 and 250 mg/kg suppressed ethanol-induced gastric lesions. The mixture of BA, BE, GL and GS (4M), each of BE, GL and GS at the dosage corresponded to HST (125 mg/kg) also suppressed the ethanol-induced gastric lesion in rats, but BA did not. Treatment of ethanol augmented the activity of myeloperoxidase (MPO) in the stomach, which was significantly suppressed by the administration of HST, BE, GL and GS. These results suggest that the protective effect of HST on ethanol-induced gastric lesion was depended on BE, GL and GS, by, in part, the reduction of MPO activity in stomach.
Kawashima
Keiko
K
Department of Kampo Medicinal Science, Hokkaido Pharmacutical University, Otaru, Japan. kkawa38@hokuyakudai.ac.jp
Fujimura
Yu
Y
Makino
Toshiaki
T
Kano
Yoshihiro
Y
D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity; D005419:Flavonoids / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology; D019695:Glycyrrhizic Acid / Q000494:pharmacology*; D008297:Male; D005894:Panax; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C088236:hange-shashinto; D001599:Berberine; C038044:baicalin; D000431:Ethanol; D019695:Glycyrrhizic Acid; D009195:Peroxidase