title: High-throughput screening: update on practices and success.
abstract: High-throughput screening (HTS) has become an important part of drug discovery at most pharmaceutical and many biotechnology companies worldwide, and use of HTS technologies is expanding into new areas. Target validation, assay development, secondary screening, ADME/Tox, and lead optimization are among the areas in which there is an increasing use of HTS technologies. It is becoming fully integrated within drug discovery, both upstream and downstream, which includes increasing use of cell-based assays and high-content screening (HCS) technologies to achieve more physiologically relevant results and to find higher quality leads. In addition, HTS laboratories are continually evaluating new technologies as they struggle to increase their success rate for finding drug candidates. The material in this article is based on a 900-page HTS industry report involving 54 HTS directors representing 58 HTS laboratories and 34 suppliers.
authors.affiliation: HighTech Business Decisions, Moraga, California 94556, USA. sfox@hightechdecisions.com
authors.forename: Sandra
authors.initials: S
authors.lastname: Fox
authors.forename: Shauna
authors.initials: S
authors.lastname: Farr-Jones
authors.forename: Lynne
authors.initials: L
authors.lastname: Sopchak
authors.forename: Amy
authors.initials: A
authors.lastname: Boggs
authors.forename: Helen Wang
authors.initials: HW
authors.lastname: Nicely
authors.forename: Richard
authors.initials: R
authors.lastname: Khoury
authors.forename: Michael
authors.initials: M
authors.lastname: Biros
mesh_terms: D002477:Cells / Q000187:drug effects / Q000378:metabolism; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000639:trends*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis
chemical_list: D004364:Pharmaceutical Preparations