title: Hypopharyngeal squamous cell carcinoma bordering ectopic gastric mucosa "inlet patch" of the cervical esophagus.
abstract: OBJECTIVE
  Ectopic gastric mucosa of the cervical esophagus, referred to as inlet patch (IP), is considered to be a common development abnormality of the esophagus. We report here a case of hypopharyngeal squamous cell carcinoma bordering on IP of the cervical esophagus.
  
  
  METHODS
  A 44-year-old female underwent partial pharyngectomy, total laryngectomy, cervical esophagectomy, and bilateral neck dissection under the diagnosis of hypopharyngeal carcinoma.
  
  
  RESULTS
  Resected specimens of the hypopharynx revealed a well-differentiated squamous cell carcinoma in the ulcerative tumorous lesion (3.5 cm x 0.5 cm). A brown patch (2 cm x 1.5 cm) bordering the anal aspect of the tumor comprised ectopic gastric mucosa of fundic type epithelium. Immunohistochemistry revealed the surface mucosal cells of this lesion were strongly positive for human gastric mucin (HGM) and the fundic cells were positive for gastrin.
  
  
  CONCLUSIONS
  The hypopharyngeal squamous cell carcinoma likely developed in association with chronic irritation due to gastric acid from the IP. To our knowledge, this is the first reported case of squamous cell carcinoma related to IP.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. satos3@cc.saga-u.ac.jp
authors.forename: Shintaro
authors.initials: S
authors.lastname: Satoh
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nakashima
authors.forename: Keiko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Shuji
authors.initials: S
authors.lastname: Toda
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kuratomi
authors.forename: Hajime
authors.initials: H
authors.lastname: Sugihara
authors.forename: Akira
authors.initials: A
authors.lastname: Inokuchi
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002828:Choristoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D004935:Esophageal Diseases / Q000150:complications / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery