title: Glycosyl bis-porphyrin conjugates: synthesis and potential application in PDT.
abstract: Syntheses of new glycosylated neutral and cationic porphyrin dimers linked at the meso-position via a flexible hydrocarbon chain are described. A detailed 1H and 13C NMR study allows their complete structural elucidation. The UV-visible, fluorescence and MALDI mass spectra are also presented. Photocytotoxicities of these compounds against K562 leukaemia cell line are compared to those of Photofrin II.
authors.affiliation: Université de Limoges - Laboratoire de Chimie des Substances Naturelles 123, Avenue Albert Thomas-87060 Limoges, France. vincent.sol@unilim.fr
authors.forename: V
authors.initials: V
authors.lastname: Sol
authors.forename: V
authors.initials: V
authors.lastname: Chaleix
authors.forename: Y
authors.initials: Y
authors.lastname: Champavier
authors.forename: R
authors.initials: R
authors.lastname: Granet
authors.forename: Y-M
authors.initials: YM
authors.lastname: Huang
authors.forename: P
authors.initials: P
authors.lastname: Krausz
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D017323:Dihematoporphyrin Ether; D019281:Dimerization; D006031:Glycosylation; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010778:Photochemotherapy / Q000379:methods*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D011166:Porphyrins; D017323:Dihematoporphyrin Ether