Ameliorating role of caffeic acid phenethyl ester (CAPE) against isoniazid-induced oxidative damage in red blood cells.
Isoniazid (INH) still remains a first-line drug both for treatment and prophylaxis of tuberculosis, but various organs toxicity frequently develops in patients receiving this drug. We aimed to investigate possible toxic effects of INH on rat red blood cells (RBCs), and to elucidate whether Caffeic acid phenethyl ester (CAPE) prevents a possible toxic effect of INH. Experimental groups were designed as follows: control group, INH group, INH + CAPE group. Compared with the control, the INH caused a significant increase in superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels, and a decrease in glutathione peroxidase (GSH-Px) and catalase (CAT), which are recently used to monitor the development and extent of damage due to oxidative stresses. CAPE administration to INH group ameliorated above changes due to INH.
Gokalp
Osman
O
Faculty of Medicine, Department of Pharmacology, Suleyman Demirel University, Isparta, Turkey. ogokalp@med.sdu.edu.tr
Uz
Efkan
E
Cicek
Ekrem
E
Yilmaz
H Ramazan
HR
Ozer
Mehmet Kaya
MK
Altunbas
Ayse
A
Ozcelik
Nurten
N
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000633:toxicity; D002109:Caffeic Acids / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology; D007538:Isoniazid / Q000633:toxicity*; D008297:Male; D018384:Oxidative Stress; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D000995:Antitubercular Agents; D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; D007538:Isoniazid