title: Constituents from the leaves of Phellodendron amurense and their antioxidant activity.
abstract: Three new coumarins, phellodenols F-H (1-3) and a new glutaric acid derivative, phellodendric acid-A (4) were isolated from the leaves of Phellodendron amurense together with twenty-nine known compounds. Extensive 1D and 2D NMR experiments and other spectroscopic studies were employed to determine the structures of 1-4. The isolated compounds were screened for their antioxidant activity through DPPH (alpha,alpha-diphenyl-beta-picrylhydrazyl) radical scavenging assay. Compounds quercetin, quercetin-3-O-beta-D-glucoside, quercetin-3-O-beta-D-galactoside and kaempferol-3-O-beta-D-glucoside demonstrated significant radical scavenging activity comparable to vitamin E.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, ROC.
authors.forename: Chien-Hsing
authors.initials: CH
authors.lastname: Leu
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Li
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000037:antagonists & inhibitors / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D015394:Molecular Structure; D032102:Phellodendron / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D000975:Antioxidants; D003374:Coumarins; D016166:Free Radical Scavengers