title: Myxoid lipoadenoma of parathyroid gland: a case report and literature review.
abstract: Myxoid lipoadenoma of the parathyroid gland is a rare variant of parathyroid adenoma. We present the case of a 40-year-old man with asymptomatic hypercalcemia who underwent surgical removal of a parathyroid adenoma. Histologically, the tumor consisted of monomorphous round-to-oval chief cells arranged in several architectural patterns including solid sheet-like, trabecular, and follicular. The tumor stroma was prominently myxoid with interspersed mature adipose tissue. Immunohistochemistry confirmed expression of thyroid transcription factor and parathyroid hormone by all tumor cells and a low proliferation rate with a Ki-67 labeling index of at most 5%. Although the lesion exhibited characteristics that have been previously associated with "atypical parathyroid adenoma," such as dense fibrous bands within the tumor and a trabecular growth pattern, there was no further evidence, neither histologically nor clinically, for malignant behavior of the tumor.
authors.affiliation: Department of Pathology, New York University School of Medicine and NYU Cancer Institute, New York Harbor Healthcare System, New York, NY 10010, USA.
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Fischer
authors.forename: Rosemary
authors.initials: R
authors.lastname: Wieczorek
authors.forename: Gurdip S
authors.initials: GS
authors.lastname: Sidhu
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Pei
authors.forename: Brian
authors.initials: B
authors.lastname: West
authors.forename: Peng
authors.initials: P
authors.lastname: Lee
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D049109:Cell Proliferation; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008067:Lipoma / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D010282:Parathyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology