[Recent findings regarding the treatment of late-onset depression with vascular brain lesions. A literature review].
BACKGROUND
Late-onset depression with vascular brain lesions is showing increased resistance to antidepressive pharmacotherapy.


OBJECTIVE
To give an overview of alternative treatment options.


METHODS
We conducted a literature search via PubMed using the key words: 'late-onset depression', 'white matter lesions', 'cerebrovascular pathology' and 'treatment' and thereby a searchfor all available clinical studies about the treatment described in combination with the key words 'vascular depression', or 'late-onset depression' and 'white matter lesions'.


RESULTS
Electroconvulsive therapy, repetitive transcranial magnetic stimulation and nimodipine au,gmentation have beneficial effects on vascular depression.


CONCLUSIONS
The treatment options mentioned are promising, but there is a need for further clinical studies.
Jans
V
V
Universitair Centrum Sint-Jozef te Kortenberg.
Bouckaert
F
F
Wils
V
V
Peuskens
J
J
D000367:Age Factors; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D003863:Depression / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D006801:Humans; D009553:Nimodipine / Q000627:therapeutic use; D012307:Risk Factors; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D014665:Vasodilator Agents; D009553:Nimodipine