Frequency and characteristics of docetaxel-induced radiation recall phenomenon.
OBJECTIVE
The aim of this study was to investigate the frequency and characteristics of a docetaxel-induced radiation recall phenomenon.


METHODS
Past histories of radiotherapy and radiation recall phenomenon (RRP) were analyzed in 461 patients who were administered docetaxel at our hospital between September 2002 and November 2005.


RESULTS
Of the 461 patients, 171 underwent radiotherapy before starting docetaxel. RRP was noted in 3 patients (1.8%). The 3 cases show that RRP tends to develop in patients treated with lower-energy photon beams of < or =6 MV and in patients with marked acute phase reactions during radiotherapy.


CONCLUSIONS
The incidence of RRP induced by docetaxel was 1.8%, making it a comparatively rare condition. However, docetaxel is increasingly being used for patients with head and neck tumors, and caution regarding development of RRP is warranted after use of docetaxel after high-dose radiotherapy with photon beams of < or =6 MV.
Mizumoto
Masashi
M
Division of Radiation Oncology, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan. mizumoto1717@hotmail.com
Harada
Hideyuki
H
Asakura
Hirofumi
H
Zenda
Sadamoto
S
Fuji
Hiroshi
H
Murayama
Shigeyuki
S
Nishimura
Tetsuo
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D015897:Comorbidity; D000077143:Docetaxel; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000453:epidemiology*; D011836:Radiation Tolerance / Q000187:drug effects*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D043823:Taxoids / Q000008:administration & dosage*
D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel