Caveolin-1 is essential for liver regeneration.
Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene-disrupted mice (cav1-/- mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy. Hepatocytes showed dramatically reduced lipid droplet accumulation and did not advance through the cell division cycle. Treatment of cav1-/- mice with glucose (which is a predominant energy substrate when compared to lipids) drastically increased survival and reestablished progression of the cell cycle. Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury.
Fernández
Manuel A
MA
Departament de Biologia Cellular, Facultat de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain.
Albor
Cecilia
C
Ingelmo-Torres
Mercedes
M
Nixon
Susan J
SJ
Ferguson
Charles
C
Kurzchalia
Teymuras
T
Tebar
Francesc
F
Enrich
Carlos
C
Parton
Robert G
RG
Pol
Albert
A
D000818:Animals; D021941:Caveolae / Q000378:metabolism; D051242:Caveolin 1 / Q000235:genetics / Q000502:physiology*; D002453:Cell Cycle; D002455:Cell Division; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D010766:Phosphorylation; D034741:RNA, Small Interfering; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D051242:Caveolin 1; D005227:Fatty Acids; D008055:Lipids; D034741:RNA, Small Interfering; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D014280:Triglycerides; D017228:Hepatocyte Growth Factor; D005947:Glucose