title: Antimicrobial activity of tigecycline against clinical isolates from Spanish medical centers. Second multicenter study.
abstract: The antimicrobial activity of tigecycline, a novel glycylcycline, was evaluated against 1102 bacterial isolates from 20 centers in Spain. The MIC of tigecycline at which 90% (MIC(90)) of the pneumococci tested were inhibited was the lowest (0.06 microg/mL) of all the antibiotics tested. The MICs of tigecycline against enterococci ranged from 0.03 to 0.125 microg/mL. All staphylococci were inhibited by < or =0.25 microg/mL of tigecycline, and 99.6% of Enterobacteriaceae isolates were inhibited by < or =2 microg/mL of tigecycline. Tigecycline demonstrated good activity against Bacteroides fragilis group organisms with an MIC(90) of 4 microg/mL. The results of this study confirm the excellent activity of tigecycline against multiresistant Gram-positive and Gram-negative pathogens.
authors.affiliation: Department of Clinical Microbiology, Hospital Clínico San Carlos, 28040 Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Betriu
authors.forename: Iciar
authors.initials: I
authors.lastname: Rodríguez-Avial
authors.forename: María
authors.initials: M
authors.lastname: Gómez
authors.forename: Esther
authors.initials: E
authors.lastname: Culebras
authors.forename: Fátima
authors.initials: F
authors.lastname: López
authors.forename: Juan
authors.initials: J
authors.lastname: Alvarez
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Picazo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D018571:Sentinel Surveillance; D013030:Spain; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline