title: Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.
abstract: A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association (P < 4.2 x 10(-9)) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Freedman
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.forename: Nick
authors.initials: N
authors.lastname: Patterson
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: McDonald
authors.forename: Arti
authors.initials: A
authors.lastname: Tandon
authors.forename: Alicja
authors.initials: A
authors.lastname: Waliszewska
authors.forename: Kathryn
authors.initials: K
authors.lastname: Penney
authors.forename: Robert G
authors.initials: RG
authors.lastname: Steen
authors.forename: Kristin
authors.initials: K
authors.lastname: Ardlie
authors.forename: Esther M
authors.initials: EM
authors.lastname: John
authors.forename: Ingrid
authors.initials: I
authors.lastname: Oakley-Girvan
authors.forename: Alice S
authors.initials: AS
authors.lastname: Whittemore
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Cooney
authors.forename: Sue A
authors.initials: SA
authors.lastname: Ingles
authors.forename: David
authors.initials: D
authors.lastname: Altshuler
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.forename: David
authors.initials: D
authors.lastname: Reich
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000368:Aged; D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D002898:Chromosomes, Human, Pair 8; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000208:ethnology* / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors
chemical_list: D005819:Genetic Markers