Phosphine-catalyzed alpha-P-addition on activated alkynes: A new route to P-C-P backbones.
n-Tributylphosphine was found to efficiently catalyze the alpha-P addition of H-phosphonates, H-phosphinates, and H-phosphine oxide pronucleophiles on alkynes bearing phosphane oxide activating moieties. The reaction leads to 2-aryl-1-vinyl-1,1-diphosphane dioxide derivatives in good yields affording a new route to P-C-P backbones. The products of this reaction are easily converted to biologically important 1,1-bis-phosphonates analogues.
Lecerclé
Delphine
D
Service de Marquage Moléculaire et de Chimie Bioorganique, Commissariat à l'Energie Atomique, Gif sur Yvette, F-91191 France.
Sawicki
Marcin
M
Taran
Frédéric
F
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D010720:Phosphines / Q000737:chemistry*
D000480:Alkynes; D010720:Phosphines