[Minocycline-induced lupus erythematodes].
We report the case of an 18-year-old woman with arthralgia and swelling of distal joints at hands and feet, photosensitive reaction, butterfly rash, fatigue, tachypnea and unspecific cardiac pain three months after beginning a treatment with minocycline for acne. Recurrence of symptoms at a higher intensity occurred within hours of reexposition with minocycline. The antinuclear antibody test was positive. After withdrawal of minocycline, the symptoms improved and minocycline-induced lupus was diagnosed. In the Swissmedic and WHO adverse drug reaction databases 267 other cases of possible minocycline-induced lupus were identified. Typical clinical and laboratory features are arthralgia, arthritis, myalgia, increased transaminases and/or jaundice, unspecific symptoms like fatigue and fever, skin disorders and positive antinuclear antibodies.
Egger
S S
SS
Klinische Pharmakologie & Toxikologie, regionales Pharmacovigilance-Zentrum, Universitätsspital, Basel. eggers@uhbs.ch
Studer
I Gehrig
IG
Rätz Bravo
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AE
Krähenbühl
S
S
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000974:Antibodies, Antinuclear / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000974:Antibodies, Antinuclear; D008911:Minocycline