Orthopedic complications of solid-organ transplantation.
Organ transplantation has undeniably increased the longevity and quality of life of patients with end-stage organ failure. Its has, however, introduced the skeletal complications of (1) fragility fractures and decreased bone density due to pretransplant bone loss and immunosuppressive therapy, and (2) avascular necrosis leading to subchondral fracture and secondary osteoarthritis. This article reviews these two skeletal complications of solid-organ transplantation that lead to structural failure of bone and result in significant morbidity and reduced quality of life.
Aaron
Roy K
RK
Department of Orthopaedics, Brown Medical School, 100 Butler Drive, Providence, RI 02906, USA. roy_aaron@brown.edu
Ciombor
Deborah McK
DM
D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology*; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016377:Organ Transplantation / Q000009:adverse effects*; D010020:Osteonecrosis / Q000209:etiology*