Biodegradable polyurethane cancellous bone graft substitutes in the treatment of iliac crest defects.
Porous scaffolds were produced from newly designed biodegradable, segmented aliphatic polyurethanes of various chemical compositions and hydrophilic-to-hydrophobic segment ratios. The scaffolds were implanted into monocortical defects in the iliac crest of healthy sheep for 6 months. The resected cortex was not repositioned. The ilium defects, which were not implanted with polyurethane scaffolds, were used as controls. In none of the control defects was there bone regeneration at the time of euthanasia. The defects implanted with porous scaffolds from polyurethanes were healed to varying extents with cancellous bone. The structure of the regenerated cancellous bone was radiographically denser than the structure of native bone. New bone that was formed in the scaffolds with a higher amount of hydrophilic component contained more calcium phosphate deposit than the bone formed in the scaffolds with a lower amount of the hydrophilic component. There was no new cortex formed over the defect, but a thin layer of soft tissue covered the newly formed cancellous bone.
Gogolewski
Sylwester
S
Polymer Research, AO Research Institute, Clavadelerstrasse, CH-7270 Davos, Switzerland. sylwester.gogolewski@aofoundation.org
Gorna
Katarzyna
K
D000818:Animals; D018786:Bone Substitutes; D002113:Calcification, Physiologic; D002130:Calcium Phosphates / Q000378:metabolism; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D020007:Implants, Experimental; D016348:Osseointegration; D011140:Polyurethanes; D011859:Radiography; D012756:Sheep
D018786:Bone Substitutes; D002130:Calcium Phosphates; D011140:Polyurethanes; C020243:calcium phosphate