Comparative effects of estradiol, raloxifene, and genistein on the uterus of ovariectomized mice.
To explore the uterine effects of administration of compounds that exert their bone-sparing functions through estrogen receptors, we administered 17beta-E2, raloxifene, or genistein to ovariectomized mice and analyzed the uterus weight and histology 4 weeks after beginning the treatments. Results indicated that raloxifene and genistein have partial agonistic properties on the uterus in estrogen-depleted mice, and that genistein induced apoptosis and several atypias in the glandular epithelium of endometrium, as demonstrated in hematoxylin-eosin-stained histological sections.
García-Pérez
Miguel Angel
MA
Research Unit, Hospital Clínico Universitario of Valencia, Valencia, Spain. migarpe@uv.es
Noguera
Rosa
R
del Val
Raquel
R
Noguera
Inmaculada
I
Hermenegildo
Carlos
C
Cano
Antonio
A
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D019833:Genistein / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010052:Ovariectomy; D020849:Raloxifene Hydrochloride / Q000494:pharmacology*; D014599:Uterus / Q000166:cytology* / Q000187:drug effects*
D020849:Raloxifene Hydrochloride; D004958:Estradiol; D019833:Genistein