Inflammatory response in human tick-borne encephalitis: analysis of postmortem brain tissue.
In Central European tick-borne encephalitis (TBE) mechanisms of tissue destruction are poorly understood. To evaluate the contribution of immunological mechanisms to tissue injury, the authors immunohistochemically analyzed paraffin-embedded autoptic brain tissue of 26 human TBE cases. In the parenchymal compartment, there was a predominance of macrophages/microglia and cytotoxic T cells. In addition, it was found that granzyme B-expressing lymphocytes were in close contact with TBE-expressing neurons up-regulating caspase-3. These findings indicate that cellular and humoral pathways of the immune system, especially granzyme B-releasing cytotoxic T cells and macrophages/microglia, mainly contribute to tissue destruction in TBE.
Gelpi
Ellen
E
Institute of Neurology, Medical University of Vienna, Austria.
Preusser
Matthias
M
Laggner
Ute
U
Garzuly
Ferenc
F
Holzmann
Heidemarie
H
Heinz
Franz Xaver
FX
Budka
Herbert
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001921:Brain / Q000276:immunology* / Q000473:pathology / Q000821:virology; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000473:pathology / Q000821:virology; D005416:Flavivirus; D053804:Granzymes / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology; D018884:Ixodes / Q000821:virology; D008264:Macrophages / Q000276:immunology; D017628:Microglia / Q000276:immunology; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000201:enzymology / Q000276:immunology
D053804:Granzymes