title: Advances in Lewis acid controlled carbon-carbon bond-forming reactions enable a concise and convergent total synthesis of bullatacin.
abstract: Lewis acids control regioselectivity in the alkylation of epi-chlorohydrin and the stereochemistry of an alkyne addition to set the C24/C23 anti relationship. These advances facilitate an efficient total synthesis of bullatacin in 13.3% overall yield from commercial starting materials.
authors.affiliation: Department of Chemistry, University of Western Ontario, London, ON N6A 5B7, Canada.
authors.forename: Hongda
authors.initials: H
authors.lastname: Zhao
authors.forename: Jeffrey S T
authors.initials: JS
authors.lastname: Gorman
authors.forename: Brian L
authors.initials: BL
authors.lastname: Pagenkopf
mesh_terms: D000143:Acids / Q000737:chemistry*; D000478:Alkylation; D005663:Furans / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000143:Acids; D005663:Furans; C061022:bullatacin