title: Glomerular volume and renal histology in obese and non-obese living kidney donors.
abstract: The link between obesity and renal disease is unclear, and there is no consensus as to whether obese individuals are at increased risk for kidney disease after living kidney donation if they otherwise meet acceptance criteria. We retrospectively studied time-zero (implantation) biopsies in 49 obese (body mass index (BMI) > or = 30 kg/m2) and 41 non-obese (BMI < 30 kg/m2) renal donors that met acceptance criteria. We found that our obese donor population had higher systolic blood pressure (P < 0.001 vs non-obese) and higher absolute iothalamate clearance (P = 0.001 vs non-obese) before donation. The obese donors had larger glomerular planar surface area compared to non-obese controls (P = 0.017), and this parameter correlated with patient weight and urinary microalbumin excretion. Detailed examination of the biopsies revealed that although most histologic findings were similar between groups, the obese donors had more tubular dilation (P = 0.01), but less tubular vacuolization (P = 0.02) than the non-obese controls. There was also a trend toward more arterial hyalinosis in the obese patients than controls (P = 0.08). From these data, our studies detected subtle differences in donor organs obtained from obese compared to non-obese individuals. Further studies should be carried out to quantify the long-term impact of these findings.
authors.affiliation: William J Von Liebig Transplant Center, Mayo Clinic College of Medicine, Rochester, Minnesota 55904, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Rea
authors.forename: J K
authors.initials: JK
authors.lastname: Heimbach
authors.forename: J P
authors.initials: JP
authors.lastname: Grande
authors.forename: S C
authors.initials: SC
authors.lastname: Textor
authors.forename: S J
authors.initials: SJ
authors.lastname: Taler
authors.forename: M
authors.initials: M
authors.lastname: Prieto
authors.forename: T S
authors.initials: TS
authors.lastname: Larson
authors.forename: F G
authors.initials: FG
authors.lastname: Cosio
authors.forename: M D
authors.initials: MD
authors.lastname: Stegall
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007678:Kidney Glomerulus / Q000166:cytology* / Q000473:pathology* / Q000502:physiology; D016030:Kidney Transplantation / Q000473:pathology; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects; D009765:Obesity / Q000473:pathology* / Q000503:physiopathology; D009929:Organ Size; D011183:Postoperative Complications / Q000517:prevention & control; D012189:Retrospective Studies