title: Outbreak of infection by carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium.
abstract: Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 17 patients between September 2004 and August 2005 at the Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium. These multidrug-resistant isolates, which belonged to a single clone, remained susceptible to colistin and tigecycline only and produced the carbapenem-hydrolyzing oxacillinase OXA-58. This study highlights the importance of the intercountry spread of this beta-lactamase-mediated resistance mechanism and its epidemic evolution.
authors.affiliation: Laboratoire de Bactériologie, Cliniques Universitaires UCL de Mont-Godinne, 1, Av. Dr Gaston Thérasse, B-5530 Yvoir, Belgium. pierre.bogaerts@mont.ucl.ac.be
authors.forename: Pierre
authors.initials: P
authors.lastname: Bogaerts
authors.forename: Thierry
authors.initials: T
authors.lastname: Naas
authors.forename: Ingrid
authors.initials: I
authors.lastname: Wybo
authors.forename: Caroline
authors.initials: C
authors.lastname: Bauraing
authors.forename: Oriane
authors.initials: O
authors.lastname: Soetens
authors.forename: Denis
authors.initials: D
authors.lastname: Piérard
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
authors.forename: Youri
authors.initials: Y
authors.lastname: Glupczynski
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology*; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D000328:Adult; D000368:Aged; D001530:Belgium / Q000453:epidemiology; D015780:Carbapenems / Q000494:pharmacology*; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D015780:Carbapenems; D001618:beta-Lactamases; C509061:beta-lactamase OXA-58, Acinetobacter junii