Perfect simulation from nonneutral population genetic models: variable population size and population subdivision.
We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. We investigate the effect of demography on the efficacy of selection and the effect of selection on genetic divergence between populations.
Fearnhead
Paul
P
Department of Mathematics and Statistics, Lancaster University, Lancaster, LA1 4YF, United Kingdom. p.fearnhead@lancs.ac.uk
D000465:Algorithms; D000483:Alleles; D000818:Animals; D003198:Computer Simulation; D014644:Genetic Variation; D008390:Markov Chains; D008957:Models, Genetic; D011153:Population / Q000235:genetics; D011156:Population Density; D012641:Selection, Genetic