Complexity beneath the silence.
Polycomb group (PcG)-mediated silencing by proteins that are conserved across plants and animals is a key feature of eukaryotic gene regulation. Investigation of PcG-mediated gene silencing has revealed a surprising degree of complexity in the molecular mechanisms that recruit the protein complexes, repress expression, and maintain the epigenetic silent state of target genes. This review summarizes our current understanding of the mechanism of PcG-mediated gene silencing in animals and higher plants.
Calonje
Myriam
M
Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA.
Sung
Z Renee
ZR
D000818:Animals; D018744:DNA, Plant; D044127:Epigenesis, Genetic; D020868:Gene Silencing; D063245:Plant Development; D010944:Plants / Q000235:genetics*; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins / Q000502:physiology*
D018744:DNA, Plant; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins