New insights regarding vessel regression.
The regression of blood vessels is an intrinsic feature of both physiological and pathological processes. This suggests the existence of molecular regulators of regression, which would be potential targets for management and therapy of numerous diseases involving angiogenesis. This review summarizes some of the prevailing views on vessel regression and highlights our recent contribution to the field.
Im
Eunok
E
Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA.
Kazlauskas
Andrius
A
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001808:Blood Vessels / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D004847:Epithelial Cells / Q000378:metabolism; D004848:Epithelium / Q000098:blood supply / Q000196:embryology / Q000254:growth & development; D006801:Humans; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D051966:Phospholipase C gamma / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A; D051966:Phospholipase C gamma