title: Lower levels of cerebrospinal fluid amyloid beta (Abeta) in non-demented Indian controls.
abstract: Prevalence of Alzheimer's disease in Indian population is lower than in developed countries. To determine whether limitation of amyloid beta (Abeta) concentration may be responsible for lower rate of incidence, we measured the levels of Abeta in cerebrospinal fluid (CSF) collected from 72 non-demented individuals ranging in the age from 20 years to 65 years. These samples were segregated into three groups ranging from 20-35 years, 36-50 years and 51-65 years of age. Levels of Abeta could be detected in all the age groups and they were much lower than the values reported in literature from the developed countries. No significant difference in the average level of Ass was observed with increase in age.
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health & Neurosciences, Bangalore 560 029, India. sarada@nimhans.kar.nic.in
authors.forename: Sarada
authors.initials: S
authors.lastname: Subramanian
authors.forename: Boya
authors.initials: B
authors.lastname: Sandhyarani
authors.forename: A N Divya
authors.initials: AN
authors.lastname: Shree
authors.forename: K Krishna
authors.initials: KK
authors.lastname: Murthy
authors.forename: K
authors.initials: K
authors.lastname: Kalyani
authors.forename: S Praveen
authors.initials: SP
authors.lastname: Kumar
authors.lastname: Pradeep
authors.forename: Mohin Jeslie
authors.initials: MJ
authors.lastname: Noone
authors.forename: A B
authors.initials: AB
authors.lastname: Taly
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D016229:Amyloid beta-Peptides