Leukocyte recruitment in atherosclerosis: potential targets for therapeutic approaches?
Atherosclerosis is a complex inflammatory disease involving cellular migration and interaction. Vascular injury in response to different cardiovascular risk factors enhances endothelial dysfunction, which in turn promotes the expression of inflammatory markers and transendothelial leukocyte migration. Recruitment of leukocytes from the blood stream into the vessel intima is a crucial step for the development of the disease. Recent findings have highlighted the role of chemokines, chemokine receptors, adhesion molecules, and gap junctions in this process by acting as chemoattractant, adhesive, or intercellular communication molecules. In this short review, we summarize new data concerning the different steps from leukocyte arrest to transendothelial migration and discuss potential new therapeutic approaches concerning these processes.
Braunersreuther
V
V
Cardiology Division, Department of Medicine, Geneva University Hospital, Foundation for Medical Research, 64 Avenue Roseraie, 1211 Geneva, Switzerland.
Mach
F
F
D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000502:physiology*