title: Adaptive vs. group sequential self-designing trials.
abstract: This is a discussion of the paper. 'Repeated Confidence Intervals in Self-Designing Clinical Trials and Switching between Non-Inferiority and Superinferiority' by Joachim Hartung and Guido Knapp, appearing in this special issue on adaptive designs.
authors.affiliation: Merck Research Laboratories, North Wales, PA 19454, USA. devan_mehrotra@merck.com
authors.forename: Devan V
authors.initials: DV
authors.lastname: Mehrotra
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Fan
mesh_terms: D001699:Biometry; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D018401:Sample Size