title: Inflammatory response in human tick-borne encephalitis: analysis of postmortem brain tissue.
abstract: In Central European tick-borne encephalitis (TBE) mechanisms of tissue destruction are poorly understood. To evaluate the contribution of immunological mechanisms to tissue injury, the authors immunohistochemically analyzed paraffin-embedded autoptic brain tissue of 26 human TBE cases. In the parenchymal compartment, there was a predominance of macrophages/microglia and cytotoxic T cells. In addition, it was found that granzyme B-expressing lymphocytes were in close contact with TBE-expressing neurons up-regulating caspase-3. These findings indicate that cellular and humoral pathways of the immune system, especially granzyme B-releasing cytotoxic T cells and macrophages/microglia, mainly contribute to tissue destruction in TBE.
authors.affiliation: Institute of Neurology, Medical University of Vienna, Austria.
authors.forename: Ellen
authors.initials: E
authors.lastname: Gelpi
authors.forename: Matthias
authors.initials: M
authors.lastname: Preusser
authors.forename: Ute
authors.initials: U
authors.lastname: Laggner
authors.forename: Ferenc
authors.initials: F
authors.lastname: Garzuly
authors.forename: Heidemarie
authors.initials: H
authors.lastname: Holzmann
authors.forename: Franz Xaver
authors.initials: FX
authors.lastname: Heinz
authors.forename: Herbert
authors.initials: H
authors.lastname: Budka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001921:Brain / Q000276:immunology* / Q000473:pathology / Q000821:virology; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000473:pathology / Q000821:virology; D005416:Flavivirus; D053804:Granzymes / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology; D018884:Ixodes / Q000821:virology; D008264:Macrophages / Q000276:immunology; D017628:Microglia / Q000276:immunology; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000201:enzymology / Q000276:immunology
chemical_list: D053804:Granzymes