title: Endoscopic, rapid near-infrared optical tomography.
abstract: This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source-detector fibers for tomography as well as parallel sampling of all source-detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.
authors.affiliation: School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, Oklahoma, USA. daqing.piao@okstate.edu
authors.forename: Daqing
authors.initials: D
authors.lastname: Piao
authors.forename: Hao
authors.initials: H
authors.lastname: Xie
authors.forename: Weili
authors.initials: W
authors.lastname: Zhang
authors.forename: Jerzy S
authors.initials: JS
authors.lastname: Krasinski
authors.forename: Guolong
authors.initials: G
authors.lastname: Zhang
authors.forename: Hamid
authors.initials: H
authors.lastname: Dehghani
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
mesh_terms: D003199:Computer Systems; D019723:Endoscopes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*