title: The fibrinotic index and evidence for a balanced regulation of coagulation activities.
abstract: The fibrinogen, plasma antithrombin, and thrombin activity curves of twenty-four normal individuals were determined under carefully controlled conditions of analysis. From these determinations plasma prothrombin and thromboplastic activities were calculated. These activities were defined in kinetic terminology and a theoretical rate of fibrination in plasma was calculated and used as a basis for comparing plasmas. Compensatory relationships were found among the various activities. Thus, low values of thromboplastic activity were associated with increased concentrations of prothrombin and fibrinogen; the effect of the latter activities in increasing the potential of plasma for fibrination was moderated by an increase in antithrombin activity. The fibrin-forming potential of each plasma was calculated relative to the mean value for all plasmas, to furnish a fibrinotic index. The latter was relatively constant in spite of wide variations in discrete activities, indicating that a physiological balance is maintained among those coagulation factors responsible for fibrination.
authors.affiliation: The Cardeza Foundation for Hematological Research Jefferson Medical College, Philadelphia, Pennsylvania, USA.
authors.forename: G F
authors.initials: GF
authors.lastname: Grannis
authors.forename: L A
authors.initials: LA
authors.lastname: Kazal
mesh_terms: D001779:Blood Coagulation Factors / Q000502:physiology*; D005340:Fibrinogen / Q000502:physiology; D005342:Fibrinolysis; D006706:Homeostasis; D006801:Humans; D012016:Reference Values; D013917:Thrombin / Q000502:physiology; D014914:Whole Blood Coagulation Time
chemical_list: D001779:Blood Coagulation Factors; D005340:Fibrinogen; D013917:Thrombin