Antimüllerian hormone and pituitary gland activity after prolonged down-regulation with goserelin acetate.
The size of the pool of growing follicles was normal after prolonged down-regulation, as indicated by normal AMH levels 4 and 8 weeks after goserelin administration. However, there was a profound down-regulation of LH levels; therefore we suggest administration of exogenous LH to proceed to IVF or alternatively stimulation of endogenous LH secretion with daily administration of GnRH agonist. These need to be assessed prospectively.
Mohamed
Kamel Abdelhakim
KA
Department of Obstetrics and Gynaecology, Northampton General Hospital, Northampton, NN1 5BD, UK. kamel.mohamed@ntlworld.com
Davies
W A R
WA
Lashen
Hany
H
D054304:Anti-Mullerian Hormone; D015536:Down-Regulation / Q000187:drug effects; D004715:Endometriosis / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006023:Glycoproteins / Q000097:blood*; D017273:Goserelin / Q000008:administration & dosage*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D010865:Pilot Projects; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D013735:Testicular Hormones / Q000097:blood*
D006023:Glycoproteins; D013735:Testicular Hormones; D017273:Goserelin; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone