title: Studies on condensed 1,4-dihydropyridine derivatives and their calcium modulatory activities.
abstract: Hexahydroquinoline and furoquinoline derivatives were synthesized and their calcium modulatory activity was investigated on isolated rat ileum and lamb carotid artery. In addition, the in vitro hepatic microsomal biotransformation of one hexahydroquinoline derivative was studied in rat microsomes.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Aydin
authors.forename: C
authors.initials: C
authors.lastname: Safak
authors.forename: R
authors.initials: R
authors.lastname: Simşek
authors.forename: K
authors.initials: K
authors.lastname: Erol
authors.forename: M
authors.initials: M
authors.lastname: Ulgen
authors.forename: A
authors.initials: A
authors.lastname: Linden
mesh_terms: D000818:Animals; D001711:Biotransformation; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D008958:Models, Molecular; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D015363:Quinolones / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D012756:Sheep; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D007202:Indicators and Reagents; D015363:Quinolones