Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the lead scaffold resulted in the identification of compounds exhibiting low-nanomolar potency and isozyme-selective ACC2 activity.
Clark
Richard F
RF
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. rick.clark@abbott.com <rick.clark@abbott.com>
Zhang
Tianyuan
T
Xin
Zhili
Z
Liu
Gang
G
Wang
Ying
Y
Hansen
T Matthew
TM
Wang
Xiaojun
X
Wang
Rongqi
R
Zhang
Xiaolin
X
Frevert
Ernst U
EU
Camp
Heidi S
HS
Beutel
Bruce A
BA
Sham
Hing L
HL
Gu
Yu Gui
YG
D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D010647:Phenyl Ethers; C031538:phenyl ether; D000103:Acetyl-CoA Carboxylase