title: Highly efficient C-C bond-forming reactions in aqueous media catalyzed by monomeric vanadate species in an apatite framework.
abstract: A calcium vanadate apatite (VAp), in which PO4(3-) of hydroxyapatite (HAP), Ca10(PO4)6(OH)2, is completely substituted by VO4(3-) in the apatite framework, was synthesized. Physicochemical analysis of the VAp reveals the presence of isolated VO4 tetrahedron units with a pentavalent oxidation state. The VAp acts as a high-performance heterogeneous base catalyst for various carbon-carbon bond-forming reactions such as Michael and aldol reactions in aqueous media and the H-D exchange reactions using deuterium oxide. For example, a 200-mmol-scale Michael reaction under triphasic conditions proceeded rapidly, with an extremely high turnover number of up to 260 400 and an excellent turnover frequency of 48 s(-1). No vanadium leaching was detected during the above reactions, and the catalyst was readily recycled with no loss of activity.
authors.affiliation: Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Hara
authors.forename: Satoko
authors.initials: S
authors.lastname: Kanai
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Mori
authors.forename: Tomoo
authors.initials: T
authors.lastname: Mizugaki
authors.forename: Kohki
authors.initials: K
authors.lastname: Ebitani
authors.forename: Koichiro
authors.initials: K
authors.lastname: Jitsukawa
authors.forename: Kiyotomi
authors.initials: K
authors.lastname: Kaneda