Lower levels of cerebrospinal fluid amyloid beta (Abeta) in non-demented Indian controls.
Prevalence of Alzheimer's disease in Indian population is lower than in developed countries. To determine whether limitation of amyloid beta (Abeta) concentration may be responsible for lower rate of incidence, we measured the levels of Abeta in cerebrospinal fluid (CSF) collected from 72 non-demented individuals ranging in the age from 20 years to 65 years. These samples were segregated into three groups ranging from 20-35 years, 36-50 years and 51-65 years of age. Levels of Abeta could be detected in all the age groups and they were much lower than the values reported in literature from the developed countries. No significant difference in the average level of Ass was observed with increase in age.
Subramanian
Sarada
S
Department of Neurochemistry, National Institute of Mental Health & Neurosciences, Bangalore 560 029, India. sarada@nimhans.kar.nic.in
Sandhyarani
Boya
B
Shree
A N Divya
AN
Murthy
K Krishna
KK
Kalyani
K
K
Kumar
S Praveen
SP
Pradeep
Noone
Mohin Jeslie
MJ
Taly
A B
AB
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D016229:Amyloid beta-Peptides