Multiple myeloma associated with sialyl salivary-type amylase.
BACKGROUND
There have been several reports describing a notable hyperamylasaemia in patients with multiple myeloma. Such amylase-producing myelomas have been mainly described in the context of concomitant salivary-type hyperamylasaemia, with sialyl salivary-type amylase identified in a portion of those cases. We investigated the incidence of the production of sialyl salivary-type amylase in serum of multiple myeloma patients.


METHODS
Eleven patients (6 male and 5 female) who had been diagnosed as having multiple myeloma were enrolled in this study. Sialyl salivary-type amylase was detected by isoamylase electrophoresis and HPLC analysis, and identified by detecting either abnormal neuraminidase-sensitive band through isoamylase electrophoresis or abnormal extra-elution peak of amylase by means of HPLC analysis.


RESULTS
Sialyl salivary-type amylase was detected in 7 out of 11 (63.6%) patients. Median total amylase activity was 154 U/l (range 109-43020). Isoamylase electrophoretic patterns of patients' serum were normal in 5 patients (71.4%) out of 7 patients and salivary-dominant in 2 (50.0%) out of 4 patients.


CONCLUSIONS
We consider that there is no significant relationship between total serum amylase level and amylase isoenzyme pattern in the incidence of production of sialyl salivary-type amylase with multiple myeloma.
Shigemura
Masahiko
M
Clinical Laboratory, Hokkaido University Hospital, N-14 W-5, Kitaku, Sapporo, 060-8648, Japan. mscoccus@med.hokudai.ac.jp
Moriyama
Takanori
T
Shibuya
Hitoshi
H
Obara
Masato
M
Endo
Tomoyuki
T
Hashino
Satoshi
S
Yokouchi
Hiroshi
H
Asaka
Masahiro
M
Shimizu
Chikara
C
Chiba
Hitoshi
H
Nishimura
Masaharu
M
D000368:Aged; D000681:Amylases / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000201:enzymology*; D012469:Salivary Glands / Q000201:enzymology*
D007527:Isoenzymes; D000681:Amylases