Behavioral interference and C/EBPbeta expression in the insular-cortex reveal a prolonged time period for taste memory consolidation.
Memory consolidation is defined as the time window during which the memory trace is susceptible to behavioral, electrical, or pharmacological interventions. Here, we presented rats with two novel tastes at consecutive time intervals. Clear interference was evident when a novel taste formed the second taste input whereby, surprisingly, the time window for interference was found to last more than 10 h. In addition, we detected an increase of C/EBPbeta protein expression in the gustatory cortex 18 h after novel taste learning. This modulation was attenuated by a subsequent novel taste. Our findings reveal temporal constraints and a lingering nature of taste memory consolidation.
Merhav
Maayan
M
Department for Neurobiology and Ethology, Center for Brain and Behavior, University of Haifa, Haifa 31905, Israel.
Kuulmann-Vander
Shelly
S
Elkobi
Alina
A
Jacobson-Pick
Shlomit
S
Karni
Avi
A
Rosenblum
Kobi
K
D000818:Animals; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004193:Discrimination Learning / Q000502:physiology*; D008297:Male; D010470:Perceptual Masking / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000502:physiology*; D013997:Time Factors
D022782:CCAAT-Enhancer-Binding Protein-beta