Endothelial progenitor cell-seeded grafts: rash and risky.
The patency of prosthetic vascular grafts is impaired by intimal hyperplasia (IH) near the anastomotic regions. The absence of a functional endothelial monolayer on the prosthetic grafts is an important stimulus for IH. To improve the outcome of synthetic vascular bypass surgery, cell seeding is a promising concept that has been extensively investigated and is still evolving. In the present paper, the concept of prosthetic graft cell seeding is discussed, with emphasis on its newest era: seeding with endothelial progenitor cells. Although experimental studies on prosthetic graft seeding using endothelial progenitor cells have shown excellent results on graft endothelialization, none of these studies reported favourable effects on the more clinically relevant end points such as IH or graft patency.
Rotmans
Joris I
JI
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands. j.i.rotmans@amc.uva.nl
Heyligers
Jan M M
JM
Stroes
Erik S G
ES
Pasterkamp
Gerard
G
D001807:Blood Vessel Prosthesis; D001026:Coronary Artery Bypass; D004730:Endothelium, Vascular / Q000166:cytology*; D006083:Graft Occlusion, Vascular / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D017539:Tunica Intima / Q000473:pathology*