[Relationship between lipid profile and body mass index. Five-year follow-up in children aged 6-11 years old. The Rivas-Vaciamadrid study].
BACKGROUND
To study the relationship between lipid profile and body mass index (BMI) in children after a 5-year follow-up.


METHODS
A total of 281 children were evaluated at the ages of 6 and 11 years. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and apoproteins A1 (Apo A) and B100 (Apo B) were measured. Low-density lipoprotein cholesterol (LDL-C) was determined and the Apo B/Apo A, TC/HDL-C, LDL-C/HDL-C indexes, and the atherogenic index were calculated. BMI was also calculated (BMI 5 kg/m2). Evolution parameters were calculated (EVO 5 value 11 years - value 6 years). Associations between BMI and lipid profile were studied.


RESULTS
The prevalence of obesity (according to the criteria of the International Obesity Task Force) was 4.98 % (6 years) and 16,72 % (11 years). In children who were in the fourth BMI quartile at the age of 11 years, LDL-C/HDL-C and TC/HDL-C levels were significantly higher and than those in children in the first quartile but HDL-C and Apo A levels were lower. A significant positive correlation was found between the evolution of BMI and the four indexes studied and TG, but this correlation was negative for HDL-C and Apo A. The evolution of the indexes was positive in 11-year-old obese children and negative in nonobese children.


CONCLUSIONS
Lipid profile was worse in 11-year-old children in the fourth BMI quartile than in the remaining children. Obese children had higher values of the indexes studied, supporting the importance of obesity as a cardiovascular risk factor.
Sánchez Bayle
M
M
Grupo de Trabajo sobre Factores de Riesgo Cardiovascular. Hospital Niño Jesús. España. masanba@teleline.es
Sánchez Bernardo
A
A
Peláez Gómez de Salazar
M J
MJ
González Requejo
A
A
Martinoli Rubino
C
C
Díaz Cirujano
A
A
D001059:Apoproteins / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
D001059:Apoproteins; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol