title: Gastric emptying in patients with Type 2 diabetes mellitus and diabetes associated with mitochondrial DNA 3243 mutation using 13C-octanoic acid breath test.
abstract: Although the (13)C-octanoic acid breath test (OBT) has been applied to diabetic patients for assessing gastric emptying, such studies are still limited. Gastric emptying was measured using solid meal containing (13)C-octanoic acid in 52 patients with Type 2 diabetes mellitus and 4 diabetic patients with mitochondrial DNA (mitDNA) 3243 mutation. Delayed gastric emptying was detected in 29% of patients with Type 2 diabetes mellitus, and multiple regression analysis showed that gastric emptying was independently associated with gastrointestinal symptoms and cardiac autonomic neuropathy. Gastric emptying was not related to gastric dysrhythmia in cutaneous electrogastrography (EGG). Diabetic patients with mitDNA 3243 mutation showed delayed gastric emptying. Because the pathogenesis of delayed gastric emptying is multifactorial in diabetic patients, the recently developed OBT is useful for studying gastric emptying in various clinical settings of diabetic patients.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: Sakae
authors.initials: S
authors.lastname: Nohara
authors.forename: Masanori
authors.initials: M
authors.lastname: Iwase
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Imoto
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sasaki
authors.forename: Udai
authors.initials: U
authors.lastname: Nakamura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Uchizono
authors.forename: Saori
authors.initials: S
authors.lastname: Abe
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Doi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001944:Breath Tests; D002210:Caprylates / Q000378:metabolism; D002247:Carbon Isotopes / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics; D048909:Diabetes Complications / Q000175:diagnosis* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D018589:Gastroparesis / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D006331:Heart Diseases / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics; D019518:Postprandial Period; D012016:Reference Values; D018709:Statistics, Nonparametric
chemical_list: D002210:Caprylates; D002247:Carbon Isotopes; D004272:DNA, Mitochondrial; C031492:octanoic acid