title: Effect of drug type on the degradation rate of PLGA matrices.
abstract: We compare the rate of drug release through the degradation of 50:50 polylactic-co-glycolic acid polymer pellets, for six different drugs: Thiothixene, Haloperidol, Hydrochlorothiozide, Corticosterone, Ibuprofen, and Aspirin. Despite using the same polymer matrix and drug loading (20% by weight), we find that the rate of polymer degradation and the drug release profile differ significantly between the drugs. We conclude that the design of biodegradable polymeric drug carriers with high drug loadings must account for the effect of the drug on the polymer degradation and drug release rate.
authors.affiliation: Stanley Center for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Siegel
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Kahn
authors.forename: Kayla
authors.initials: K
authors.lastname: Metzger
authors.forename: Karen I
authors.initials: KI
authors.lastname: Winey
authors.forename: Kathryn
authors.initials: K
authors.lastname: Werner
authors.forename: Nily
authors.initials: N
authors.lastname: Dan
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D014150:Antipsychotic Agents / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D003345:Corticosterone / Q000737:chemistry; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers; D006220:Haloperidol / Q000737:chemistry; D006852:Hydrochlorothiazide / Q000737:chemistry; D006868:Hydrolysis; D007052:Ibuprofen / Q000737:chemistry; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008956:Models, Chemical; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013888:Thiothixene / Q000737:chemistry; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D014150:Antipsychotic Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D006852:Hydrochlorothiazide; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D013888:Thiothixene; D006220:Haloperidol; D001241:Aspirin; D003345:Corticosterone; D007052:Ibuprofen