Cardiovascular pharmacology and physiology of the isoprostanes.
F(2)-isoprostanes are a complex family of compounds produced from arachidonic acid via a free radical-catalyzed mechanism. Their quantification as a pathophysiological biomarker provides a unique opportunity to investigate lipid peroxidation in vascular diseases. Their measurement also provides an interesting biomarker for the rational dose selection of antioxidants in vascular diseases where oxidative stress might be involved. In addition to their use as biomarkers, some isoprostanes possess a biological activity. The 15-series F(2)- and E(2)-isoprostanes mediate vasoconstriction in different vascular beds and species. In addition, 15-F(2t)-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. The data available supports but does not prove the hypothesis that isoprostanes are involved in vascular physiology and pathogenesis.
Cracowski
Jean-Luc
JL
Laboratoire de Pharmacologie, Inserm ESPRI, HP2 EA 3745, Faculté de Médecine de Grenoble, France. jean-luc.cracowski@ujf-grenoble.fr
Durand
Thierry
T
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism*; D002319:Cardiovascular System / Q000378:metabolism; D006801:Humans; D028421:Isoprostanes / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D015227:Lipid Peroxidation
D015415:Biomarkers; D028421:Isoprostanes