title: Four butenolides are novel cytotoxic compounds isolated from the marine-derived bacterium, Streptoverticillium luteoverticillatum 11014.
abstract: Four known butenolides were isolated from the ethyl acetate extracts of the culture broth of the marine-derived bacterium, Streptoverticillium luteoverticillatum, by bioassay-guided fractionation. The structures were identified on the basis of spectral data. The absolute configuration of compound (1) was determined by CD spectrum for the first time. Compounds 1-4 showed in vitro cytotoxicity against the murine lymphoma P388 and human leukemia K562 cell lines. This is the first report on the isolation of butenolides from the marine bacterium, Streptoverticillium luteoverticillatum, and their cytotoxic activities.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, Qingdao, PR China.
authors.forename: De-Hai
authors.initials: DH
authors.lastname: Li
authors.forename: Tian-Jiao
authors.initials: TJ
authors.lastname: Zhu
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Liu
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Fang
authors.forename: Qian-Qun
authors.initials: QQ
authors.lastname: Gu
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D005663:Furans