Calcium signaling: double duty for calcium at the mitochondrial uniporter.
Uptake of Ca(2+) by mitochondria serves as a regulator of a number of important cellular functions, including energy metabolism, cytoplasmic Ca(2+) signals, and apoptosis. Recent findings reveal that the process of Ca(2+) uptake by the mitochondrial uniporter is itself regulated by Ca(2+) in a temporally complex manner.
Putney
James W
JW
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences - NIH, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. putney@niehs.nih.gov
Thomas
Andrew P
AP
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000502:physiology; D025461:Feedback, Physiological / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological
D015220:Calcium Channels; C034703:mitochondrial calcium uniporter; D002118:Calcium