title: Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population.
abstract: BACKGROUND
  Genetic factors and oxidative damage have been shown to have a role in the development of primary open angle glaucoma (POAG).
  
  
  OBJECTIVE
  To determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population.
  
  
  METHODS
  Using a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with POAG and in 121 otherwise healthy controls of similar age.
  
  
  RESULTS
  The GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (p<0.001, OR 2.93, 95% CI 1.66 to 5.20 and OR 4.25, 95% CI 2.30 to 7.80, respectively). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p<0.001, OR 3.46, 95% CI 1.64 to 7.38).
  
  
  CONCLUSIONS
  The GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with the increased risk of development of POAG in the Turkish population.
authors.affiliation: Department of Ophthalmology, Akdeniz University Medical Faculty, Antalya, Turkey. mustafaunalmd@gmail.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Unal
authors.forename: Mehmet
authors.initials: M
authors.lastname: Güven
authors.forename: Kazim
authors.initials: K
authors.lastname: Devranoğlu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozaydin
authors.forename: Bahadir
authors.initials: B
authors.lastname: Batar
authors.forename: Nevbahar
authors.initials: N
authors.lastname: Tamçelik
authors.forename: Ebru Eroğlu
authors.initials: EE
authors.lastname: Görgün
authors.forename: Didar
authors.initials: D
authors.lastname: Uçar
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sarici
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1