title: Predictors of left ventricular dysfunction in patients with first acute anterior myocardial infarction undergoing primary angioplasty.
abstract: BACKGROUND
  The degree of left ventricular dysfunction determines the prognostic outcome of patients with acute myocardial infarction.
  
  
  OBJECTIVE
  To define the clinical, angiographic and procedural variables related to LV dysfunction in patients with anterior wall AMI referred for primary percutaneous coronary intervention.
  
  
  METHODS
  The sample included 168 patients treated by primary PCI for first anterior wall AMI. Clinical, demographic and medical data were collected prospectively into a computerized registry, and clinical outcome (death, reinfarction, major cardiovascular event) were evaluated during hospitalization and 30 days after discharge. Patients were divided into three groups by degree of LV dysfunction (mild, moderate, severe) and compared for clinical, angiographic and procedural variables.
  
  
  RESULTS
  LV dysfunction was associated with pre-PCl renal failure (serum creatinine > 1.4 mg/dl), peripheral vascular disease, high peak creatine kinase level, longer door to balloon time, low TIMI flow grade before and after PCl, and use of an intraaortic balloon pump. On multivariate analysis adjusted for baseline differences, peak creatine kinase level (r = 0.3, P = 0.0001) and door to needle time (r = 0.2, P = 0.008) were the most significant independent predictors of moderate or severe LV dysfunction after anterior AMI.
  
  
  CONCLUSIONS
  Abnormal LV function after first anterior AMI can be predicted by door to balloon time and the size of the infarction as assessed by creatine kinase levels. Major efforts should be made to decrease the time to myocardial reperfusion.
authors.affiliation: Cardiac Catheterization Laboratories, Department of Cardiology, Rabin Medical Center (Beilinson Campus), Petah Tiqva, Israel.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Hamdan
authors.forename: Ran
authors.initials: R
authors.lastname: Kornowski
authors.forename: Alejandro
authors.initials: A
authors.lastname: Solodky
authors.forename: Shmuel
authors.initials: S
authors.lastname: Fuchs
authors.forename: Alexander
authors.initials: A
authors.lastname: Battler
authors.forename: Abid R
authors.initials: AR
authors.lastname: Assali
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003401:Creatine / Q000097:blood; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications* / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology
chemical_list: D003401:Creatine