title: Echocardiographic right ventricular strain analysis in chronic heart failure.
abstract: OBJECTIVE
  We sought to compare the additive value of right ventricular (RV) function assessed by longitudinal systolic strain (epsilon% - ROI: 9.2 at 10.8 mm) with cardiopulmonary exercise testing (CPET) or brain natriuretic peptide (BNP) in patients with heart failure (HF).
  
  
  METHODS
  We studied 19-patients (age = 56 +/- 8 years) in New York Heart Association HF class III-IV, who underwent standard and tissue Doppler echocardiography, CPET and BNP measurements on the same day. RV function was assessed by systolic strain (epsilon, %, ROI: 9.2-10.8 mm) in the mid-segment. Clinical outcomes were examined at 6 months.
  
  
  RESULTS
  epsilon (-19.9+/-6.8%) was correlated with BNP (R = 0.52, P = 0.02), slope VE/VCO(2) (R = -0.65, P = 0.003), peak VO(2) (R = 0.46, P = 0.04) and the maximal workload (Watts) developed during CPET (R = 0.54, P=0.02). During follow-up, 1-patient died, 1-underwent heart transplantation, and 4 were re-hospitalized for worsening HF. Patients with major adverse cardiac events (MACE) had a significantly higher mean BNP concentration (852.8 ng/mL +/- 1114.3 vs. 201.4+ /- 293.8, P = 0.03), higher VE/VCO(2) (41.3 +/- 3.6 vs. 35.0 +/- 4.8 P < 0.001) and lower epsilon (-13.9 +/- 4.9 vs. -22.2+ /- 5.8, P < 0.001) than patients who remained MACE-free. By multivariate analysis, ST was the only predictor of MACE.
  
  
  CONCLUSIONS
  In HF-patients presenting, RV-function assessed by systolic epsilon was reliable, easily measurable and a stronger prognosticator than CPET or BNP.
authors.affiliation: Department of Cardiology, University Hospital, CCP- CHU Pontchaillou, 35000 Rennes, France. erwan.donal@chu-rennes.fr
authors.forename: Erwan
authors.initials: E
authors.lastname: Donal
authors.forename: Manuel
authors.initials: M
authors.lastname: Roulaud
authors.forename: Pascale
authors.initials: P
authors.lastname: Raud-Raynier
authors.forename: Claire
authors.initials: C
authors.lastname: De Bisschop
authors.forename: Christophe
authors.initials: C
authors.lastname: Leclercq
authors.forename: Geneviève
authors.initials: G
authors.lastname: Derumeaux
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Daubert
authors.forename: Philippe
authors.initials: P
authors.lastname: Mabo
authors.forename: André
authors.initials: A
authors.lastname: Denjean
mesh_terms: D002908:Chronic Disease; D015150:Echocardiography, Doppler; D005080:Exercise Test; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011379:Prognosis; D012372:ROC Curve; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000503:physiopathology*
chemical_list: D020097:Natriuretic Peptide, Brain