title: [Three cases of chronic bird fancier's lung associated with the use of feather bedclothes].
abstract: We report here 3 cases of chronic bird fancier's lung diagnosed immunologically using antibodies to pigeon dropping extract. None of the patients were bird fanciers but had indirect exposure to birds in their living environment, and had been using feather-filled duvets or pillows for a long time. Two of 3 cases were positive for environmental provocation tests and 2 cases had pathological findings of hypersensitivity pneumonitis such as multinucleated giant cells and non-necrotizing epithelioid cell granulomas. One case was resistant to steroid therapy alone and was successfully treated by coadministration of prednisolone and cyclosporin A. Another case was treated by steroid alone but died of acute exacerbation of unknown cause. These cases suggest that not only feathers but two or more kinds of bird-related antigens were involved in the sensitization immunology and development of bird fancier's disease, and that clinicians should perform thorough history taking with environmental surveillance relevant to birds.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine.
authors.forename: Seiko
authors.initials: S
authors.lastname: Nakayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Kanako
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Mioko
authors.initials: M
authors.lastname: Ide
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Isimoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Hisatomi
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Kiyoyasu
authors.initials: K
authors.lastname: Fukushima
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000368:Aged; D000818:Animals; D001512:Bedding and Linens; D001706:Biopsy; D001716:Bird Fancier's Lung / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D002908:Chronic Disease; D005241:Feathers; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013906:Thoracoscopy; D014057:Tomography, X-Ray Computed