Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors.
Mast cells play a central role in inflammatory and allergic reactions by releasing inflammatory mediators through two main pathways, immunoglobulin E-dependent and -independent activation. In the latter, mast cells are activated by a diverse range of basic molecules, including peptides and amines such as substance P, neuropeptide Y, and compound 48/80. These secretagogues are thought to activate the G proteins in mast cells through a receptor-independent mechanism. Here, we report that the basic molecules activate G proteins through the Mas-related gene (Mrg) receptors on mast cells, leading to mast cell degranulation. We suggest that one of the Mrg receptors, MrgX2, has an important role in regulating inflammatory responses to non-immunological activation of human mast cells.
Tatemoto
Kazuhiko
K
Department of Molecular Physiology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan. ktatemoto@ace.odn.ne.jp
Nozaki
Yuko
Y
Tsuda
Ryoko
R
Konno
Shinobu
S
Tomura
Keiko
K
Furuno
Masahiro
M
Ogasawara
Hiroyuki
H
Edamura
Koji
K
Takagi
Hideo
H
Iwamura
Hiroyuki
H
Noguchi
Masato
M
Naito
Takayuki
T
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002478:Cells, Cultured; D000071438:Fatty Acid-Binding Protein 7; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar; D043562:Receptors, G-Protein-Coupled / Q000276:immunology* / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution; D025521:Tumor Suppressor Proteins / Q000378:metabolism
D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D043562:Receptors, G-Protein-Coupled; D025521:Tumor Suppressor Proteins; D007073:Immunoglobulin E