title: A combination of oral cabergoline and double cloprostenol injections to produce third-quarter gestation termination in the bitch.
abstract: To assess the efficacy and safety of a combined cabergoline and cloprostenol protocol to terminate third-quarter pregnancy, 22 pregnant bitches that ranged from 35 to 45 days after mating were randomly assigned to a treatment group (n=13) or to an untreated control group (n=9). The animals were monitored for 12 days, and pregnancy termination was confirmed by ultrasound examination. Twelve of the 13 treated bitches aborted within 9 days of the initiation of treatment (mean 4.6 days). Only mild side effects were observed. The control animals had normal gestational courses, as did the bitch that did not respond to the therapy. This combination of drugs appeared to be a practical, safe, and efficient abortifacient when used in third-quarter pregnancies.
authors.affiliation: Imaging Diagnosis Service, Faculty of Veterinary Medicine, National University of La Plata, La Plata, Argentina.
authors.forename: Yanina
authors.initials: Y
authors.lastname: Corrada
authors.forename: Raúl
authors.initials: R
authors.lastname: Rodríguez
authors.forename: Mariana
authors.initials: M
authors.lastname: Tortora
authors.forename: Daniel
authors.initials: D
authors.lastname: Arias
authors.forename: Cristina
authors.initials: C
authors.lastname: Gobello
mesh_terms: D000019:Abortifacient Agents / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods / Q000662:veterinary*; D000034:Abortion, Veterinary / Q000139:chemically induced*; D000284:Administration, Oral; D000818:Animals; D000077465:Cabergoline; D003008:Cloprostenol / Q000008:administration & dosage; D004285:Dogs; D018491:Dopamine Agonists / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004873:Ergolines / Q000008:administration & dosage; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D008186:Luteolytic Agents / Q000008:administration & dosage; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D000019:Abortifacient Agents; D018491:Dopamine Agonists; D004873:Ergolines; D008186:Luteolytic Agents; D003008:Cloprostenol; D000077465:Cabergoline