title: Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans.
abstract: In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the alpha,beta-unsaturated ester side chain at position 2 of the THP ring.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
authors.forename: Romen
authors.initials: R
authors.lastname: Carrillo
authors.forename: Leticia G
authors.initials: LG
authors.lastname: León
authors.forename: Tomás
authors.initials: T
authors.lastname: Martín
authors.forename: Víctor S
authors.initials: VS
authors.lastname: Martín
authors.forename: José M
authors.initials: JM
authors.lastname: Padrón
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006859:Hydrogen / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011714:Pyrans; D006859:Hydrogen