Small cell lung carcinoma presenting as collapsin response-mediating protein (CRMP) -5 paraneoplastic optic neuropathy.
A 77-year-old woman presenting with progressive visual loss in both eyes was found to have small cell lung cancer. Assay for collapsin response-mediating protein (CRMP) -5 was positive suggesting a paraneoplastic optic neuropathy (PON). During treatment of the small cell lung cancer, the patient died of pneumonia and autopsy disclosed neuropathologic abnormalities consistent with PON. This is only the second case of CRMP-5-confirmed PON to report neuropathologic findings.
Sheorajpanday
Rishi
R
Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium.
Slabbynck
Hans
H
Van De Sompel
Wivine
W
Galdermans
Danny
D
Neetens
Ingrid
I
De Deyn
Peter Paul
PP
D000368:Aged; D000912:Antibodies, Neoplasm / Q000097:blood; D018288:Carcinoma, Small Cell / Q000150:complications*; D005260:Female; D006801:Humans; D006867:Hydrolases; D008279:Magnetic Resonance Imaging / Q000379:methods; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism*; D009901:Optic Nerve Diseases / Q000378:metabolism*; D020364:Paraneoplastic Polyneuropathy / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D040121:Semaphorin-3A / Q000378:metabolism*
D000912:Antibodies, Neoplasm; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D040121:Semaphorin-3A; C415087:DPYSL5 protein, human; D006867:Hydrolases