title: Association of corticotropin-releasing hormone gene variation with performance and meat quality traits in commercial pig lines.
abstract: The porcine corticotropin-releasing hormone(CRH) gene is a functional-positional candidate for quantitative tract loci on porcine chromosome 4 with major effects on growth and carcass composition. In addition, the central role of CRH in the neuroendocrine response to stress implicates the CRH gene as a functional candidate for meat quality. Association of a single nucleotide polymorphism (SNP) in the promoter region of the porcine CRH gene (g.233C > T) with several growth, carcass and meat quality traits was examined using more than 2000 individuals from four commercial lines: German Landrace (LR), Pietrain (Pi), German Large White x German Landrace (F1) and the German commercial fattening pig cross of Pietrain x F1 (PiF1). Significant association of the CRH SNP was found with feed conversion ratio in the PiF1 line, with carcass length in the LR line and with lean content in the F1, LR and Pi lines. Moreover, significant association with meat colour was found in the Pi and LR lines; however, the effects were in opposite directions. The presented results indicate that sequence variation in the porcine CRH gene has no major effect on growth and carcass composition in commercial pig lines, although it may significantly contribute to variation in meat quality. The g.233C>T SNP may be in incomplete linkage disequilibrium with causal mutations and/or exhibit effects in the context of DNA variation at other interacting loci.
authors.affiliation: Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals (FBN), 18196 Dummerstorf, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Muráni
authors.forename: S
authors.initials: S
authors.lastname: Ponsuksili
authors.forename: K
authors.initials: K
authors.lastname: Schellander
authors.forename: K
authors.initials: K
authors.lastname: Wimmers
mesh_terms: D000818:Animals; D001823:Body Composition / Q000235:genetics; D049628:Body Size / Q000235:genetics; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D005838:Genotype; D008460:Meat; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013552:Swine / Q000033:anatomy & histology / Q000235:genetics* / Q000254:growth & development
chemical_list: D003346:Corticotropin-Releasing Hormone