Further evidence of MAO-A gene variants associated with bipolar disorder.
The aim of this study was to investigate MAOA gene variants in bipolar disorder by using a family-based association approach. The first sample included 331 nuclear families from Western and Central Canada with at least 1 offspring affected with bipolar disorder comprising a total of 1,044 individuals. All subjects were genotyped for MAOA-941T > G and -uVNTR gene variants using PCR techniques. Haplotype TDT was statistically significant (LRS = 12.17; df = 3; P = 0.0068; permutation global significance = 0.00098), with the T-4 haplotype significantly associated with bipolar disorder (OR = 1.63, 95% CI = 1.11-2.37). Single marker analysis evidenced a borderline association for MAOA-941T > G (P = 0.04), but not for the uVNTR. Pooling the Canadian sample with a second previously reported Italian sample genotyped for the uVNTR variant, negative results were obtained as well. No different results were detected when analyzing female subjects separately. In conclusion, our family-based association study gives mild but further support of the involvement of MAOA variants in bipolar disorder.
Müller
Daniel J
DJ
Department of Psychiatry, Charité University Medicine Berlin, PUK der Charité im SHK, Charité Campus Mitte, Berlin, Germany.
Serretti
Alessandro
A
Sicard
Tricia
T
Tharmalingam
Subi
S
King
Nicole
N
Artioli
Paola
P
Mandelli
Laura
L
Lorenzi
Cristina
C
Kennedy
James L
JL
D000328:Adult; D001483:Base Sequence; D001714:Bipolar Disorder / Q000201:enzymology* / Q000235:genetics*; D002170:Canada; D004247:DNA / Q000235:genetics; D005190:Family; D005260:Female; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007558:Italy; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D008995:Monoamine Oxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D004247:DNA; D008995:Monoamine Oxidase