Versatile, fragrant, convertible isonitriles.
The metalation of oxazoles leads to ring opening to the isocyanoenolate that can be O-acylated to give the unsaturated isonitriles. These substances undergo conventional multicomponent reactions. The products of their reactions are readily converted to acyl substitution products by treatment with acid and a nucleophile. These unsaturated isonitriles are notable by their simple preparations and, unusually, their nonoffensive odors.
Pirrung
Michael C
MC
Department of Chemistry, University of California, Riverside, California 92521, USA. michael.pirrung@ucr.edu
Ghorai
Subir
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