Enantioselective conjugate radical addition to alpha'-hydroxy enones.
Enantioselective conjugate radical addition to alpha'-hydroxy alpha,beta-unsaturated ketones, compounds containing bidentate donors, has been investigated. It has been found that radical additions to alpha'-hydroxy alpha,beta-unsaturated ketones in the presence of Mg(NTf2)2 and bisoxazoline ligand 5a proceeded cleanly, yielding the addition products in high chemical yields and good enantiomeric excesses.
Lee
Sunggi
S
Center for Molecular Design & Synthesis and Department of Chemistry, School of Molecular Science (BK-21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
Lim
Chae Jo
CJ
Kim
Sunggak
S
Subramaniam
Rajesh
R
Zimmerman
Jake
J
Sibi
Mukund P
MP
D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism
D007659:Ketones