title: Use of intradermal dilutional testing and skin prick testing: clinical relevance and cost efficiency.
abstract: OBJECTIVE
  The objective was to determine the agreement of the positive results from a multiple skin prick test (SPT) device with the ability to determine a definable endpoint through intradermal dilutional testing (IDT) to compare semiquantitatively the degree of positivity of SPT results with quantitative results from IDT and to analyze the cost of immunotherapy based on SPT compared with IDT guided by SPT.
  
  
  METHODS
  Retrospective review of clinical data (random accrual).
  
  
  METHODS
  One hundred thirty-four patients underwent allergy screening using a multiple SPT device. Antigens testing positive by skin prick device were tested using IDT on a separate day. Antigens testing negative by SPT were not evaluated by IDT. Regional allergy testing practice patterns were determined, and a cost analysis using Medicare rates was performed
  
  
  RESULTS
  There was good agreement between an antigen testing positive by SPT and the determination of a definable endpoint (93.33%, n = 1,334 antigens). The degree of positivity from the SPT correlated poorly with the final endpoint concentration (r = 0.40, P < .0001). Blended testing techniques were similar in cost when compared with several commonly used allergy testing protocols.
  
  
  CONCLUSIONS
  Antigens which show reactivity to a multiple SPT device usually have a treatable endpoint that is independent of the degree of positivity of the SPT result. IDT is an important step in the determination of the strongest starting dose of immunotherapy that may be safely administered. Initiating immunotherapy in this manner may potentially create significant health care savings by shortening the time required for a patient to reach their individual maximally tolerated dose. The use of a relatively large screening panel is cost effective and does not increase the average number of antigens treated by immunotherapy. Blended allergy testing techniques that include IDT in their protocol are comparable in cost with commonly used allergy testing protocols.
authors.affiliation: Carolina Ear, Nose and Throat Head and Neck Surgery Center, Hickory, North Carolina, USA.
authors.forename: Merritt
authors.initials: M
authors.lastname: Seshul
authors.forename: Harold
authors.initials: H
authors.lastname: Pillsbury
authors.forename: Thomas
authors.initials: T
authors.lastname: Eby
mesh_terms: D000328:Adult; D005260:Female; D017048:Health Care Costs; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D007428:Intradermal Tests / Q000191:economics / Q000295:instrumentation*; D008297:Male; D006278:Medicare; D012189:Retrospective Studies; D015927:Skin Test End-Point Titration; D018709:Statistics, Nonparametric