title: Role of ventral striatal dopamine D1 receptor in cigarette craving.
abstract: BACKGROUND
  Several theories of cigarette craving suggest that dopaminergic function in the ventral striatum plays an important role. The objective of this study was to determine correlations between craving-related brain activation and dopamine D1 receptor (D1R) binding in smokers.
  
  
  METHODS
  Twelve smokers and 12 nonsmoking controls underwent [(15)O]H(2)O-positron emission tomography activation study and D1R-binding study using [(11)C]SCH 23390, and the correlations between receptor binding and cue-induced regional cerebral blood flow (rCBF) changes were assessed. Consecutive D1R-binding changes were examined during a period of 6 months of postsmoking abstinence in five smokers.
  
  
  RESULTS
  Cue-induced activation was observed in the left ventral striatum including the nucleus accumbens in smokers. D1R binding in the ventral striatum showed a negative relationship with cue-induced craving and rCBF changes. D1R binding was significantly low in smokers, and there was a trend of increase after smoking abstinence.
  
  
  CONCLUSIONS
  D1R binding and cue-induced rCBF changes in the ventral striatum suggest the important role of D1R in this region in cigarette craving.
authors.affiliation: Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yasuno
authors.forename: Miho
authors.initials: M
authors.lastname: Ota
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ando
authors.forename: Tomomichi
authors.initials: T
authors.lastname: Ando
authors.forename: Jun
authors.initials: J
authors.lastname: Maeda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ichimiya
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takano
authors.forename: Talant K
authors.initials: TK
authors.lastname: Doronbekov
authors.forename: Yota
authors.initials: Y
authors.lastname: Fujimura
authors.forename: Shoko
authors.initials: S
authors.lastname: Nozaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suhara
mesh_terms: D000328:Adult; D001552:Benzazepines; D002560:Cerebrovascular Circulation / Q000502:physiology; D003463:Cues; D003627:Data Interpretation, Statistical; D018492:Dopamine Antagonists; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D017072:Neostriatum / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D012907:Smoking / Q000235:genetics* / Q000523:psychology*; D016540:Smoking Cessation / Q000523:psychology; D013375:Substance Withdrawal Syndrome / Q000000981:diagnostic imaging / Q000235:genetics / Q000523:psychology
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1