title: Tumour-positive sentinel node findings in patients with ductal carcinoma in situ.
abstract: BACKGROUND
  Our aim was to evaluate the prevalence of and risk factors for tumour-positive sentinel node (SN) findings in patients with ductal carcinoma in situ (DCIS).
  
  
  METHODS
  Altogether 1,470 patients underwent sentinel node biopsy (SNB) between April 2001 and March 2005 in our unit. According to a histopathological review, 11 of them had microinvasive and 74 pure DCIS and were included in the study.
  
  
  RESULTS
  Five patients (7%) with pure DCIS had SN metastases. Three of them had isolated tumour cells (ITC) only. Axillary clearance without further metastatic findings was performed in three patients. The median histological size of DCIS was larger, 50 (45-60) mm in patients with metastatic SN findings than the median of 18 (2-110) mm in those with tumour-negative SN, P=0.0103. All five patients with metastatic SN findings underwent mastectomy. Metastatic SN findings were detected in one (9%) patient with microinvasive DCIS.
  
  
  CONCLUSIONS
  Metastatic SN findings in patients with pure DCIS may be a sign of missed invasion.
authors.affiliation: Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland. marjut.leidenius@hus.fi
authors.forename: M
authors.initials: M
authors.lastname: Leidenius
authors.forename: K
authors.initials: K
authors.lastname: Salmenkivi
authors.forename: K
authors.initials: K
authors.lastname: von Smitten
authors.forename: P
authors.initials: P
authors.lastname: Heikkilä
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental / Q000706:statistics & numerical data; D008875:Middle Aged; D010173:Palpation; D011446:Prospective Studies; D012307:Risk Factors; D021701:Sentinel Lymph Node Biopsy