Water-soluble poly(ethylenimine)-based nitric oxide donors: preparation, characterization, and potential application in hemodialysis.
A novel approach to potentially resolve serious thrombosis issues associated with kidney dialysis (hemodialysis) therapies is described. New water-soluble polymeric nitric oxide (NO) donors, based on the diazeniumdiolated branched poly(ethylenimine)s and their derivatives, are prepared and characterized. These macromolecular NO donors (with up to 4.15 micromol/mg of total NO release) are utilized as additives to the dialysate solution of model dialysis filters. The presence of these species can create a localized increase in NO levels at the high surface area dialysis fiber/blood interface within the hemodialyzers. Nitric oxide is a naturally occurring and potent anti-platelet agent and is expected to greatly decrease the risk of thrombosis in the dialysis units.
Zhou
Zhengrong
Z
Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Annich
Gail M
GM
Wu
Yiduo
Y
Meyerhoff
Mark E
ME
D002264:Carboxylic Acids / Q000737:chemistry; D004867:Equipment Design; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009569:Nitric Oxide / Q000737:chemistry; D020030:Nitric Oxide Donors / Q000737:chemistry*; D009573:Nitrites / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry*; D006435:Renal Dialysis / Q000295:instrumentation* / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared; D013927:Thrombosis / Q000517:prevention & control / Q000628:therapy; D013997:Time Factors; D014867:Water / Q000737:chemistry
D002264:Carboxylic Acids; D020030:Nitric Oxide Donors; D009573:Nitrites; D014867:Water; D009569:Nitric Oxide; D011094:Polyethyleneimine