Unique expression of human papilloma virus type 5 and type 16 in esophageal squamous cell carcinoma-a case report.
The role of human papilloma virus (HPV) in esophageal cancers from the low-incidence area (Western population) is unclear. We report a case of esophageal squamous papillomatosis associated with underlying esophageal squamous cell carcinoma (OSCC). The esophagectomy specimen confirmed presence of HPV-5 and HPV-16 suggesting a viral etiology. The significance of this dual infection is not known, but it suggests that esophageal papillomatosis is premalignant and should receive regular endoscopic follow-up. This is the first report of both HPV-5 and HPV-16 DNA detected in an esophageal cancer occurring in the Western population.
Saravanan
Ramasamy
R
Department of Gastroenterology, Royal Liverpool and Broadgreen University Hospitals, Liverpool, United Kingdom.
Youshya
Silva
S
Campbell
Fiona
F
Ran
Handong
H
Morris
Anthony I
AI
Proby
Charlotte
C
D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D004279:DNA, Viral / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D027383:Papillomaviridae / Q000235:genetics*
D004279:DNA, Viral