Suppression of carrageenan- and collagen II-induced inflammation in mice by geranium oil.
To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 mu L of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice.
Maruyama
Naho
N
Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, Tokyo 192-0395, Japan.
Ishibashi
Hiroko
H
Hu
Weimin
W
Morofuji
Shinichiro
S
Inouye
Shigeharu
S
Yamaguchi
Hideyo
H
Abe
Shigeru
S
D000818:Animals; D001169:Arthritis, Experimental / Q000517:prevention & control*; D002351:Carrageenan; D024043:Collagen Type II / Q000276:immunology*; D031315:Geranium; D007249:Inflammation / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009822:Oils, Volatile / Q000627:therapeutic use*; D009195:Peroxidase / Q000378:metabolism
D024043:Collagen Type II; D009822:Oils, Volatile; D002351:Carrageenan; D009195:Peroxidase