title: Suppression of carrageenan- and collagen II-induced inflammation in mice by geranium oil.
abstract: To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 mu L of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice.
authors.affiliation: Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, Tokyo 192-0395, Japan.
authors.forename: Naho
authors.initials: N
authors.lastname: Maruyama
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Weimin
authors.initials: W
authors.lastname: Hu
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Morofuji
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Inouye
authors.forename: Hideyo
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000517:prevention & control*; D002351:Carrageenan; D024043:Collagen Type II / Q000276:immunology*; D031315:Geranium; D007249:Inflammation / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009822:Oils, Volatile / Q000627:therapeutic use*; D009195:Peroxidase / Q000378:metabolism
chemical_list: D024043:Collagen Type II; D009822:Oils, Volatile; D002351:Carrageenan; D009195:Peroxidase