title: [Mechanisms of specific immunotherapy].
abstract: Specific immunotherapy (SIT) is a well-established and clinically effective treatment for allergic rhinitis and bronchial asthma. The immunological mechanisms of the subcutaneously applied immunotherapy have been partially elucidated over the past several years but are not completely understood. This report summarizes the immunological and immunoregulatory changes during SIT of wasp venom allergic patients. The induction of IL-10-producing regulatory T cells is described.
authors.affiliation: SFB 548 Allergie und Autoimmunität, Universitäts-Hautklinik Mainz, Mainz, Deutschland. bellinghausen@hautklinik.klinik.uni-mainz.de
authors.forename: I
authors.initials: I
authors.lastname: Bellinghausen
authors.forename: J
authors.initials: J
authors.lastname: Knop
authors.forename: J
authors.initials: J
authors.lastname: Saloga
mesh_terms: D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology*; D003888:Desensitization, Immunologic / Q000379:methods*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000276:immunology*; D018448:Models, Immunological; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents