[Antiheparin activity of the aneurysm wall and parietal thrombus and blood plasma of patients with aortic aneurysm].
Aneurysm dilatation is filled by parietal thrombus. Its magnitude is determined by the ratio of coagulative to anticoagulative activities above all. The aim of the study was to assess antiheparin activity, contents of heparin neutralizing chemical compounds and glycosaminoglycans with anticoagulative activity as well in the aneurysm wall, parietal thrombus filling the aneurysm dilatation and blood plasma/blood serum of patients with aortic aneurysm. The studied material consisted of aneurysm walls and parietal thrombi extracts, as well as of blood plasma/serum of patients with aortic aneurysm. Extracts of normal aorta from organ donors and blood plasma/serum of healthy subjects were the control material. Antiheparin and antithrombin III activities, as well as contents of heparin neutralizing compounds and heparin-like acting glycosaminoglycans were evaluated in the investigated material with chemical methods. The aneurysm wall, parietal thrombus filling the aneurysm dilatation and blood plasma of patients with aortic aneurysm show high antiheparin activity and increased content of heparin neutralizing compounds. However differences in glycosaminoglycans content were not demonstrated. That can predispose to formation and enlargement of parietal thrombus in aneurysm dilatation.
Gacko
Marek
M
Klinika Chirurgii Naczyń i Transplantacji Akademii Medycznej w Białymstoku. mgacko@poczta.onet.pl
Worowska
Anna
A
Kowalewski
Radosław
R
Guzowski
Andrzej
A
Lapiński
Radosław
R
Panek
Bogusław
B
D001012:Aorta, Abdominal / Q000737:chemistry* / Q000503:physiopathology; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology*; D001777:Blood Coagulation / Q000502:physiology*; D006493:Heparin / Q000032:analysis*; D006494:Heparin Antagonists / Q000032:analysis*; D006801:Humans; D010949:Plasma / Q000737:chemistry; D010978:Platelet Factor 4 / Q000032:analysis*; D013927:Thrombosis / Q000503:physiopathology*
D006494:Heparin Antagonists; D010978:Platelet Factor 4; D006493:Heparin