Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy.
We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/epsilon2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95% confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95% CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95% CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.
Seripa
Davide
D
Laboratory of Geriatrics and Gerontology, Research Department, IRCCS Casa Sollievo della Sofferenza, Viale San Giovanni Rotondo, Italy. dseripa@operapadrepio.it
Franceschi
Marilisa
M
Matera
Maria G
MG
Panza
Francesco
F
Kehoe
Patrick G
PG
Gravina
Carolina
C
Orsitto
Giuseppe
G
Solfrizzi
Vincenzo
V
Di Minno
Giovanni
G
Dallapiccola
Bruno
B
Pilotto
Alberto
A
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D006823:Hybrid Vigor; D007558:Italy; D016015:Logistic Models; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors
D001057:Apolipoproteins E; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A