title: Chromosomal clustering of nuclear genes encoding mitochondrial and chloroplast proteins in Arabidopsis.
abstract: We present a statistical analysis of chromosomal clustering among nuclear genes encoding mitochondrial or chloroplast proteins in Arabidopsis. For both organelles, the clustering was significantly increased above the expectation, but the clustering effect was weak, and most clusters were small and dispersed. Clustered genes showed coexpression but not more than expected, and no substantial synteny was detected in other eukaryotic genomes. We propose that the unexpected clustering results from continuous selection favoring chromosomal proximity of genes acting in the same organelle.
authors.affiliation: Center for Genomics and Bioinformatics, Karolinska Institutet, S-17177 Stockholm, Sweden.
authors.forename: Andrey
authors.initials: A
authors.lastname: Alexeyenko
authors.forename: A Harvey
authors.initials: AH
authors.lastname: Millar
authors.forename: James
authors.initials: J
authors.lastname: Whelan
authors.forename: Erik L L
authors.initials: EL
authors.lastname: Sonnhammer
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism; D002736:Chloroplasts / Q000235:genetics*; D032461:Chromosomes, Plant; D016000:Cluster Analysis; D017343:Genes, Plant; D024101:Mitochondrial Proteins / Q000235:genetics*; D012275:Oryza
chemical_list: D024101:Mitochondrial Proteins