title: Silymarin and its components scavenge phenylglyoxylic ketyl radicals.
abstract: The antioxidant properties of silymarin and its flavanolignan components (silybin, silychristin and silydianin) were tested. Silymarin, silychristin and silydianin exhibit relatively good antioxidant effectiveness against phenylglyoxylic ketyl radicals and DPPH. The most effective scavengers of phenylglyoxylic ketyl radicals were silymarin and silychristin whereas silydianin was ca. 5-times less active than the first two compounds whereas silybin was ineffective. The scavenging properties of the studied compounds against DPPH radicals were in the same sequence: silymarin>silychristin>silydianin>silybin.
authors.affiliation: Comenius University in Bratislava, Faculty of Natural Sciences, Institute of Chemistry, 842 15 Bratislava, Slovakia. sersen@fns.uniba.sk
authors.forename: Frantisek
authors.initials: F
authors.lastname: Sersen
authors.forename: Tomas
authors.initials: T
authors.lastname: Vencel
authors.forename: Julius
authors.initials: J
authors.lastname: Annus
mesh_terms: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006038:Glyoxylates / Q000737:chemistry; D006801:Humans; D008333:Mandelic Acids / Q000737:chemistry; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012639:Seeds; D012838:Silymarin
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006038:Glyoxylates; D008333:Mandelic Acids; D010851:Picrates; D010936:Plant Extracts; D012838:Silymarin; C012482:phenylglyoxylic acid; C004931:1,1-diphenyl-2-picrylhydrazyl