[The value of a urine protein-to-creatinine ratio assessment in a single voided urine specimen in prediction of 24-hour proteinuria in pregnancy induced hypertension].
OBJECTIVE
Detecting proteinuria is an integral part in management of hypertensive pregnant women. The measurement of protein excretion in a 24-hour urine collection is used as the gold standard for the diagnosis and follow-up of pathologic urinary excretion. However, 24-hour urine collection is time consuming, cumbersome and often inaccurate especially during pregnancy. Pregnant women find it very inconvenient and difficult.


OBJECTIVE
The study was undertaken to validate the prediction of 24-hour protein excretion by a single voided urine protein-to-creatinine ratio in hospitalized hypertensive pregnant women.


METHODS
The study was performed in the Pregnancy Pathology Ward, City Hospital in Gdynia in 2002-2004. Pregnant women at > or = 20 weeks with hypertension (blood pressure > or = 140/90 mmHg) with proteinuria at initial urine examination were evaluated. A protein-to-creatinine ratio was obtained from first voided urine sample next morning and then urine was collected for next 24 hours for measurement of protein excretion.


RESULTS
44 women were evaluated. A total of 56 cases of the 24-hour urine collection were analyzed. There is a close correlation between the protein-to-creatinine ratio in random urine samples and the 24-hour protein excretion measured by 24-hour urine collection. Pearson correlation coefficient R=0,85 (P<0,001, R2= 0,73). A protein-to-creatinine ratio < 0,2 (g/g) can rule out significant proteinuria (defined as 24-hour urinary protein excretion > 300 mg) with sensitivity 92,0%, specificity 90,32%, positive predictive value 88,46%, negative predictive value 93,33%.


CONCLUSIONS
The protein-to-creatinine ratio of a single urine sample correlate with the 24-hour urine protein excretion. A protein-to-creatinine ratio < 0,2 (g/g) can rule out significant proteinuria.
Skweres
Tomasz
T
Oddział Połozniczo-Ginekologiczny Szpitala Miejskiego w Gdyni. tomaszskweres@wp.pl
Preis
Krzysztof
K
Ciepłuch
Rafał
R
Miśkiewicz
Krzysztof
K
D000328:Adult; D000419:Albuminuria / Q000652:urine; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000652:urine*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods; D011507:Proteinuria / Q000175:diagnosis* / Q000209:etiology* / Q000652:urine; D012189:Retrospective Studies; D016387:Women's Health
D015415:Biomarkers; D003404:Creatinine