title: Germinal-centre reactions in allergic inflammation.
abstract: Primary and secondary immune responses in the germinal centres of lymphoid organs have been studied in the past. There is now compelling evidence of a third stage in the immune response, in 'tertiary lymphoid organs' that develop at sites of chronic inflammation in response to persistent local antigen challenge. Germinal-centre-like reactions are well-documented in the target organs of autoimmune diseases. Here, we review recent evidence that they also occur at sites of allergic inflammation.
authors.affiliation: Randall Division of Cell and Molecular Biophysics, King's College London, UK. hannah.gould@kcl.ac.uk
authors.forename: Hannah J
authors.initials: HJ
authors.lastname: Gould
authors.forename: Pooja
authors.initials: P
authors.lastname: Takhar
authors.forename: Helen E
authors.initials: HE
authors.lastname: Harries
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Durham
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Corrigan
mesh_terms: D000818:Animals; D018858:Germinal Center / Q000276:immunology* / Q000473:pathology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology; D017578:Immunoglobulin Class Switching; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000235:genetics; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: D007073:Immunoglobulin E