[Effects of shuangshen ningxin capsule on mini-porcine myocardial ischemia model induced by thrombosis via cardiac catheterization intervention].
OBJECTIVE
To investigate the establishment of mini-porcine myocardial ischemia (MI) model induced by thrombosis via cardiac catheterization intervention, and observe the anti-MI action of Shuangshen Ningxin Capsule (SNC).


METHODS
MI model of Chinese mini-porcine was established by injection of self-thrombus in left anterior descending coronary artery (LAD) with guiding catheter through carotid artery. The effect of SNC on MI was evaluated comprehensively by analyzing the parameters as coronary embolism, 30 dots surface mapping electrocardiogram and quantitative histology, etc.


RESULTS
LAD in the model animals was basically embolized 6 days after modeling, showing increase of amplitude and dot of ST segment elevation. After being administered with SNC for 6 days, the self-thrombus blocked LAD was recanalized and the degree and extent of MI reduced.


CONCLUSIONS
It is the first time to successfully establish MI model of Chinese mini-procine by thrombosis via cardiac catheterization intervention. SNC has anti-MI effect.
Liu
Jian-xun
JX
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091. jianxun@ht.rol.cn.net
Yu
Zhen
Z
Li
Xin-zhi
XZ
D000818:Animals; D002214:Capsules; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy*; D008517:Phytotherapy; D013552:Swine; D013556:Swine, Miniature
D002214:Capsules; D004365:Drugs, Chinese Herbal