title: Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis.
abstract: The application of parallel synthesis to lead optimization programs in drug discovery has been an ongoing challenge since the first reports of library synthesis. A number of approaches to the application of parallel array synthesis to lead optimization have been attempted over the years, ranging from widespread deployment by (and support of) individual medicinal chemists to centralization as a service by an expert core team. This manuscript describes our experience with the latter approach, which was undertaken as part of a larger initiative to optimize drug discovery. In particular, we highlight how concepts taken from the manufacturing sector can be applied to drug discovery and parallel synthesis to improve the timeliness and thus the impact of arrays on drug discovery.
authors.affiliation: The Bristol-Myers Squibb Pharmaceutical Research Institute, Route 206 and Provinceline Road, Princeton, New Jersey 08543, USA. Harold.Weller@bms.com
authors.forename: Harold N
authors.initials: HN
authors.lastname: Weller
authors.forename: David S
authors.initials: DS
authors.lastname: Nirschl
authors.forename: Edward W
authors.initials: EW
authors.lastname: Petrillo
authors.forename: Michael A
authors.initials: MA
authors.lastname: Poss
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Andres
authors.forename: Cullen L
authors.initials: CL
authors.lastname: Cavallaro
authors.forename: Martin M
authors.initials: MM
authors.lastname: Echols
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Grant-Young
authors.forename: John G
authors.initials: JG
authors.lastname: Houston
authors.forename: Arthur V
authors.initials: AV
authors.lastname: Miller
authors.forename: R Thomas
authors.initials: RT
authors.lastname: Swann
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015195:Drug Design