title: Correlations between clinical parameters and interleukin-6 and interleukin-10 levels in saliva from totally edentulous patients with peri-implant disease.
abstract: OBJECTIVE
  The purpose of the present study was (1) to assess the relationship between clinical parameters and concentrations of the proinflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10 in the saliva of totally edentulous patients with implant-supported overdentures; (2) to assess whether estimation of IL-6 and IL-10 levels in saliva could be a useful laboratory tool to detect changes preceding serious clinical complications.
  
  
  METHODS
  Thirty healthy adult volunteers (14 men and 16 women) with implant-supported overdentures were recruited from Tallinn Dental Clinic. The biochemical and clinical parameters evaluated were the levels of IL-6 and IL-10 in saliva, pocket probing depth (mm), Gingival Index (0,1, 2, or 3), and bleeding on probing (0 or 1).
  
  
  RESULTS
  The level of IL-6 in saliva in the peri-implant disease group was significantly elevated compared to the healthy group. IL-10 could be detected only in the saliva of patients with peri-implant disease, and it did not appear at detectable amounts in saliva of healthy controls. In addition, the levels of IL-6 and IL-10 in peri-implant disease group were positively correlated with clinical parameters.
  
  
  CONCLUSIONS
  These data suggest that a significant relationship exists between the amount of a proinflammatory cytokine (IL-6) and the inflammatory response in peri-implant tissue. The results also suggest that IL-6 and IL-10 could be used as markers of peri-implant disease together and that the level of the latter cytokine gives additional information about the potency of an organism's integrated immune response for maintenance of inflammatory balance.
authors.affiliation: Dentistry Clinic and Institute of Biochemistry, Tartu University, Tartu, Estonia. stalis@hot.ee
authors.forename: Stanislav
authors.initials: S
authors.lastname: Liskmann
authors.forename: Tiiu
authors.initials: T
authors.lastname: Vihalemm
authors.forename: Olev
authors.initials: O
authors.lastname: Salum
authors.forename: Kersti
authors.initials: K
authors.lastname: Zilmer
authors.forename: Krista
authors.initials: K
authors.lastname: Fischer
authors.forename: Mihkel
authors.initials: M
authors.lastname: Zilmer
mesh_terms: D000328:Adult; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D003828:Denture, Overlay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis*; D008297:Male; D009066:Mouth, Edentulous / Q000276:immunology; D010510:Periodontal Diseases / Q000276:immunology*; D010512:Periodontal Index; D012463:Saliva / Q000737:chemistry*; D018709:Statistics, Nonparametric
chemical_list: D015921:Dental Implants; D015850:Interleukin-6; D016753:Interleukin-10