title: A protocol for the handling of tissue obtained by operative lung biopsy: recommendations of the chILD pathology co-operative group.
abstract: This is the first of a series on pediatric pulmonary disease that will appear as Perspectives in Pediatric Pathology over the coming months. The series will include practical issues, such as this protocol for handling lung biopsies and another on bronchoalveolar lavage in childhood, as well as reviews of advances in various areas in pediatric pulmonary pathology. It has been 11 years since the last Perspectives on pulmonary disease. Much has happened since then in this area, and this collection will highlight some emerging and rapidly advancing areas in pediatric lung disease. These will include a review of molecular mechanisms of lung development, and another of mechanisms of pulmonary vascular development. The surfactant system and its disorders, as well as recent advances in the biology of the pulmonary neuroendocrine system and mechanisms of respiratory viral disease, will be addressed. Articles on pulmonary hypertension, pulmonary neoplasia, and pediatric lung transplantation, with their implications for the pediatric pathologist, are also planned. The contributors to this series are a diverse group with special interests and expertise in these areas. As Dr. William Thurlbeck noted in his foreword to the previous volume, Pulmonary Disease, volume 18 of Perspectives in Pediatric Pathology, pediatric pathology had been largely concerned with phenomenology, rather than with mechanisms, model systems, and experimental investigation. I think he would have been pleased to see the changes that have occurred over the past 10 years in pediatric lung biology and pathology in particular, because these were particularly favored interests of his later years.
authors.affiliation: Department of Pathology, Texas Children's Hospital, Houston, and Division of Surgical Pathology, Washington University School of Medicine, St. Louis, MO, USA. cxlangst@texaschildrenshospital.org
authors.forename: Claire
authors.initials: C
authors.lastname: Langston
authors.forename: Kathleen
authors.initials: K
authors.lastname: Patterson
authors.forename: Megan K
authors.initials: MK
authors.lastname: Dishop
authors.forename: Fred
authors.initials: F
authors.lastname: Askin
authors.forename: Peter
authors.initials: P
authors.lastname: Baker
authors.forename: Pauline
authors.initials: P
authors.lastname: Chou
authors.forename: Carlyne
authors.initials: C
authors.lastname: Cool
authors.forename: Susan
authors.initials: S
authors.lastname: Coventry
authors.forename: Ernest
authors.initials: E
authors.lastname: Cutz
authors.forename: Mary
authors.initials: M
authors.lastname: Davis
authors.forename: Gail
authors.initials: G
authors.lastname: Deutsch
authors.forename: Csaba
authors.initials: C
authors.lastname: Galambos
authors.forename: Judy
authors.initials: J
authors.lastname: Pugh
authors.forename: Susan
authors.initials: S
authors.lastname: Wert
authors.forename: Frances
authors.initials: F
authors.lastname: White
mesh_terms: D002648:Child; D002675:Child, Preschool; D006801:Humans; D001706:Biopsy / Q000379:methods; D008168:Lung / Q000473:pathology / Q000601:surgery; D008171:Lung Diseases / Q000175:diagnosis / Q000473:pathology; D013048:Specimen Handling / Q000379:methods