title: Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata.
abstract: A new 2-arylbenzofuran, puerariafuran (1), as well as three known compounds, coumestrol (2), daidzein (3), and genistein (4), were isolated from a MeOH extract of the roots of Pueraria lobata as active constituents, using an in vitro bioassay based on the inhibition of advanced glycation end products (AGEs) to monitor chromatographic fractionation. The structure of 1 was determined by spectroscopic data interpretation, particularly by extensive 1D and 2D NMR studies. All the isolates (1-4) were evaluated for the inhibitory activity on AGEs formation in vitro.
authors.affiliation: Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Yuseong-gu, Daejon 305-811, Korea.
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Jang
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Yun Mi
authors.initials: YM
authors.lastname: Lee
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Kim
authors.forename: Joo-Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Kim
mesh_terms: D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology*; D003375:Coumestrol / Q000737:chemistry / Q000302:isolation & purification; D019833:Genistein / Q000737:chemistry / Q000302:isolation & purification; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D006031:Glycosylation; D066298:In Vitro Techniques; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry*; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; D017127:Glycation End Products, Advanced; D007529:Isoflavones; C514034:puerariafuran; C004742:daidzein; D019833:Genistein; D003375:Coumestrol