title: Uniformly-sized, molecularly imprinted polymers for nicotine by precipitation polymerization.
abstract: Uniformly-sized, molecularly imprinted polymers (MIPs) for (S)-nicotine have been prepared by a precipitation polymerization method using methacrylic acid (MAA) or 2-(trifluoromethyl)acrylic acid (TFMAA) as a functional monomer and divinylbenzene (DVB) as a cross-linker in a mixture of toluene and acetonitrile. The (S)-nicotine-imprinted MAA-co-DVB polymers were monodispersed microspheres of about 4 microm in diameter, while the TFMAA-co-DVB ones were gel-like. Molecular recognition abilities of the former MIPs were evaluated for nicotine and its structurally related compounds in liquid chromatography using a mixture of sodium phosphate buffer and acetonitrile as the eluent. Enantioseparation of nicotine was attained using the (S)-nicotine-imprinted MAA-co-DVB polymers. Furthermore, they could selectively trap nicotine in cigarette smoke extracts.
authors.affiliation: Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan.
authors.forename: Haruyo
authors.initials: H
authors.lastname: Sambe
authors.forename: Kaori
authors.initials: K
authors.lastname: Hoshina
authors.forename: Ruin
authors.initials: R
authors.lastname: Moaddel
authors.forename: Irving W
authors.initials: IW
authors.lastname: Wainer
authors.forename: Jun
authors.initials: J
authors.lastname: Haginaka
mesh_terms: D011232:Chemical Precipitation; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry; D009538:Nicotine / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D012906:Smoke / Q000032:analysis; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry; D014026:Nicotiana / Q000737:chemistry
chemical_list: D008689:Methacrylates; D011108:Polymers; D012906:Smoke; D013343:Styrenes; C008384:methacrylic acid; D009538:Nicotine