Evidence of linkage to psychosis on chromosome 5q33-34 in pedigrees ascertained for bipolar disorder.
It is hypothesized that the presence of psychotic features may define a subtype of bipolar disorder that is more homogeneous in its genetic predisposition than bipolar disorder as a whole. We used psychosis as an alternative phenotype definition in a re-analysis of the NIMH Bipolar Genetics Initiative data sets. In this analysis we selected only those families in which at least two members were diagnosed with bipolar disorder type 1 with psychotic features. This analysis identified a linkage signal on chromosome 5q33-q34, a region previously implicated in independent linkage studies of schizophrenia and of psychosis, broadly defined. This finding is consistent with the hypothesis that susceptibility to psychosis may characterize at least a subtype of bipolar disorder.
Kerner
Berit
B
Department of Psychiatry and Biobehavioral Sciences, Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, CA 90095-1761, USA. bkerner@mednet.ucla.edu
Brugman
Diana L
DL
Freimer
Nelson B
NB
D001714:Bipolar Disorder / Q000145:classification / Q000235:genetics* / Q000523:psychology; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011618:Psychotic Disorders / Q000235:genetics*; D018709:Statistics, Nonparametric
D005819:Genetic Markers