title: Prognostic value of phospholipase A2 group II, C-reactive protein and Simplified Acute Physiological Score II in intensive care patients.
abstract: We investigated the prognostic value of group II phospholipase A2 (PLA2-II) and C-reactive protein (CRP) in patients of the intensive care unit (ICU) who developed severe inflammatory reaction. In addition, the biochemical markers were correlated with the Simplified Acute Physiological Score II (SAPS II). Our study comprised 40 patients with multiple injuries and 35 patients with sepsis admitted to the ICU, and assessed during a follow-up of as long as 28 days. There were 18 survivors and 17 non-survivors in the sepsis group, and 22 survivors and 18 nonsurvivors in the group of patients with multiple injuries. In the group of patients with multiple injuries, the intensity of host inflammatory response showed clearly distinct PLA2-II and CRP profiles: the overall levels of PLA2-II and CRP were significantly higher in non-survivors than in survivors. PLA2-II and CRP do not discriminate nonsurvivors from survivors with sepsis. ROC (receiver operating characteristic curve) analysis and the area under the curve (AUC) showed the best classification of polytrauma patients with SAPS II and PLA2-II. In the group of patients with sepsis, only SAPS II appeared to be the most helpful predictive measure regarding patient outcome.
authors.affiliation: Institute of Medical Biochemistry, Clinical Centre of Serbia, Belgrade, Serbia & Montenegro. dajak@ptt.yu
authors.forename: Marijana
authors.initials: M
authors.lastname: Dajak
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ignjatović
authors.forename: Nada
authors.initials: N
authors.lastname: Majkić-Singh
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Lausević
authors.forename: Vesna
authors.initials: V
authors.lastname: Bukumirović
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D002097:C-Reactive Protein / Q000378:metabolism; D003422:Critical Care; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis*
chemical_list: D002097:C-Reactive Protein; D010741:Phospholipases A; D054467:Phospholipases A2