SEBINI: Software Environment for BIological Network Inference.
The Software Environment for BIological Network Inference (SEBINI) has been created to provide an interactive environment for the deployment and evaluation of algorithms used to reconstruct the structure of biological regulatory and interaction networks. SEBINI can be used to compare and train network inference methods on artificial networks and simulated gene expression perturbation data. It also allows the analysis within the same framework of experimental high-throughput expression data using the suite of (trained) inference methods; hence SEBINI should be useful to software developers wishing to evaluate, compare, refine or combine inference techniques, and to bioinformaticians analyzing experimental data. SEBINI provides a platform that aids in more accurate reconstruction of biological networks, with less effort, in less time.


BACKGROUND
A demonstration website is located at https://www.emsl.pnl.gov/NIT/NIT.html. The Java source code and PostgreSQL database schema are available freely for non-commercial use.
Taylor
Ronald C
RC
Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory Richland, WA, USA. ronald.taylor@pnl.gov
Shah
Anuj
A
Treatman
Charles
C
Blevins
Meridith
M
D000465:Algorithms; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D016247:Information Storage and Retrieval / Q000379:methods; D008954:Models, Biological; D011381:Programming Languages; D015398:Signal Transduction / Q000502:physiology*; D012984:Software; D049490:Systems Biology / Q000379:methods*; D014584:User-Computer Interface