title: [Multivariate regressive analysis of prognosis of liver metastases from colorectal cancer].
abstract: OBJECTIVE
  It is not very clear about the factors that affect the prognosis of liver metastases from colorectal cancer. This study was to investigate the clinicopathologic factors related to the prognosis of liver metastases from colorectal cancer.
  
  
  METHODS
  The clinicopathologic factors and follow-up data of 197 patients with liver metastases from colorectal cancer, treated from Jan. 1996 to Dec. 2000, were analyzed retrospectively. The prognostic index (PI) of patients was calculated based on the results of multivariate analysis and patients were classified into different hazard groups accordingly.
  
  
  RESULTS
  The overall 1-, 3-, and 5-year survival rates were 59.04%, 17.73%, and 11.48%. Univariate analysis revealed that extrahepatic invasion, primary tumor resection, liver metastasis resection, type of primary tumor, serum CEA concentration, number and size of liver metastases, and distribution of liver metastases were associated with prognosis. Multivariate analysis identified that the resection of liver metastases, serum CEA concentration, number and size of liver metastases were prognostic factors. The patients were classified into high risk, moderate risk, and low risk groups according to the PI value, and there was significant difference in survival rates between each two groups.
  
  
  CONCLUSIONS
  Liver metastasis resection, serum CEA concentration, number and size of liver metastases are important prognostic factors for liver metastases from colorectal cancer. In order to improve the survival rate, liver metastases should be resected for suitable patients. Moreover, PI value could be used to predict the prognosis of patients with liver metastases from colorectal cancer.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China. zhouzhiw@pub.guangzhou.gd.cn
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhou
authors.forename: Jing-Qing
authors.initials: JQ
authors.lastname: Ren
authors.forename: De-Sen
authors.initials: DS
authors.lastname: Wan
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Lu
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Pan
authors.forename: Li-Ren
authors.initials: LR
authors.lastname: Li
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Wu
authors.forename: Pei-Rong
authors.initials: PR
authors.lastname: Ding
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012004:Rectal Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate
chemical_list: D002272:Carcinoembryonic Antigen