title: Some aspects of the application of internal pilot studies.
abstract: This is a discussion of the paper' Sample size recalculation in internal pilot study designs' by Tim Friede and Meinhard Kieser, appearing in this special issue on adaptive designs.
authors.affiliation: US Food and Drug Administration, USA. lachenbruchpa@aol.com
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lachenbruch
authors.forename: Janet
authors.initials: J
authors.lastname: Wittes
mesh_terms: D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D015233:Models, Statistical; D010865:Pilot Projects; D012107:Research Design / Q000706:statistics & numerical data*; D018401:Sample Size