title: Irgarol inhibits the synthesis of ATP in mitochondria from rat liver.
abstract: The interactions of Irgarol with rat liver mithocondrial have been investigated. The results indicate that Irgarol inhibits the ATP synthesis. The analysis of the various steps involved in the ATP synthesis suggests that the inhibition is due to the opening of small-size pores.
authors.affiliation: Dipartimento di Scienze Ambientali, Università di Venezia, DD 2137, 30123 Venice, Italy. bragadin@unive.it
authors.forename: Marcantonio
authors.initials: M
authors.lastname: Bragadin
authors.forename: Francesca
authors.initials: F
authors.lastname: Cima
authors.forename: Loriano
authors.initials: L
authors.lastname: Ballarin
authors.forename: Sabrina
authors.initials: S
authors.lastname: Manente
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000187:drug effects; D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone / Q000494:pharmacology; D019069:Cell Respiration / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D010539:Permeability; D011522:Protons; D051381:Rats; D017208:Rats, Wistar; D014227:Triazines / Q000008:administration & dosage / Q000009:adverse effects*; D014475:Uncoupling Agents / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D009840:Oligomycins; D011522:Protons; D014227:Triazines; D014475:Uncoupling Agents; C103341:irgarol 1051; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases