Synthesis of 2-vinylic indoles and derivatives via a Pd-catalyzed tandem coupling reaction.
A novel one-step synthesis of valuable 2-vinylic indoles and their tricycle derivatives is described. This reaction, which utilizes a gem-dibromovinyl unit as a readily available starting material, occurs via an efficient Pd-catalyzed tandem Buchwald-Hartwig/Heck reaction.
Fayol
Aude
A
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
Fang
Yuan-Qing
YQ
Lautens
Mark
M