Improved pharmacological properties for superoxide dismutase modified with beta-cyclodextrin-carboxymethylcellulose polymer.
Superoxide dismutase was glycosidated with cyclodextrin-branched carboxymethylcellulose. The modified enzyme contained 1.4 mol polymer per mol protein and retained 87% of the initial activity. The anti-inflammatory activity of superoxide dismutase was 2.2-times increased after conjugation and its plasma half-life time was prolonged from 4.8 min to 7.2 h.
Valdivia
Aymara
A
Center for Enzyme Technology, University of Matanzas, Autopista a Varadero Km. 3.5, Matanzas, C.P. 44740, Cuba.
Pérez
Yunel
Y
Ramírez
Hector
H
Cao
Roberto
R
Villalonga
Reynaldo
R
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D002266:Carboxymethylcellulose Sodium / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D002351:Carrageenan; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005528:Foot; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000493:pharmacokinetics*; D047392:beta-Cyclodextrins / Q000737:chemistry
D000893:Anti-Inflammatory Agents; C516431:CMC-CD compound; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D002351:Carrageenan; D013482:Superoxide Dismutase; C031215:betadex; D002266:Carboxymethylcellulose Sodium