title: Reduction of inhibition in the inferior colliculus after inner hair cell loss.
abstract: Effects of carboplatin-induced partial loss of inner hair cells on rate-level functions of neurons in the central nucleus of the inferior colliculus of the same chinchillas before and 1-3 months after carboplatin treatment were examined. Partial inner hair cell loss caused only a small elevation of response thresholds but induced a significant increase in the proportion of monotonic and a significant decrease in the proportion of non-monotonic rate-level functions at the characteristic frequency of 210 multiunits. This indicates that inhibition in the inferior colliculus is reduced after sensory deafferentation. We conclude that some of the functional changes reported in the auditory cortex after peripheral deafferentation are already realized at the level of the inferior colliculus.
authors.affiliation: Physiology II, JW Goethe-University, Frankfurt am Main, Germany.
authors.forename: Ala
authors.initials: A
authors.lastname: Alkhatib
authors.forename: Ulrich W
authors.initials: UW
authors.lastname: Biebel
authors.forename: Jean W T
authors.initials: JW
authors.lastname: Smolders
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D001307:Auditory Perception / Q000502:physiology; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology; D016190:Carboplatin / Q000633:toxicity; D016923:Cell Death / Q000187:drug effects; D016009:Chi-Square Distribution; D002682:Chinchilla; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects / Q000473:pathology*; D007245:Inferior Colliculi / Q000473:pathology*; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin