title: [Surgical treatment efficacy of bronchioloalveolar carcinoma: a retrospective analysis of 130 patients].
abstract: OBJECTIVE
  Bronchioloalveolar carcinoma (BAC) is a well-differentiated lung adenocarcinoma occurring in the periphery of the lung and growing along an intact interstitial framework. There are controversies about the surgical treatment efficacy of BAC. This study was to explore the surgical treatment efficacy of BAC.
  
  
  METHODS
  Data were collected from 130 patients with BAC, hospitalized in the department of Thoracic Surgery, Cancer Center of Sun Yat-sen University, diagnosed by postoperative pathology from 1985 to 2000. Clinical and histological features, approaches and outcomes of surgical treatment according to different TNM stages and clinical patterns were studied retrospectively.
  
  
  RESULTS
  Of the 130 patients, 56.1% were men, 42.9% were women. The ratio of smoker to non-smoker was 1:1.55. Ninety-eight patients underwent complete resection and 32 underwent incomplete resection. Patients in stage I (n=54), stage II (n=15), stage III B (2/11), and stage IV (1/19) underwent complete resection, of whom the 5-year survival rates were 60.7%, 33.3%, 13.6%, and 14.0%, respectively. Patients of unifocal (96/113), multifocal (1/12), and pneumonic (1/19) patterns underwent complete resection, of whom the median survival time was 46.3, 20.6, and 5 months. The 1-, 3-, and 5-year survival rates were 96.4%, 58.6%, and 41.2% for the unifocal pattern, 91.2%, 41.7%, and 33.3% for the multifocal pattern, 20%, 0, and 0 for the pneumonic pattern.
  
  
  CONCLUSIONS
  Complete surgical resection can achieve favorable survival rates for BAC in stage I/II and multifocal BAC in stage III/IV, whereas relatively poorer prognosis for pneumonic BAC.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.
authors.forename: Zhi-Chao
authors.initials: ZC
authors.lastname: Lin
authors.forename: Hao
authors.initials: H
authors.lastname: Long
authors.forename: Tie-Hua
authors.initials: TH
authors.lastname: Rong
authors.forename: Ming-Tian
authors.initials: MT
authors.lastname: Yang
authors.forename: Zhi-Fan
authors.initials: ZF
authors.lastname: Huang
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
authors.forename: Lan-Jun
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome