title: Collagen solubility correlates with skin optical clearing.
abstract: Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.
authors.forename: Jason
authors.initials: J
authors.lastname: Hirshburg
authors.forename: Bernard
authors.initials: B
authors.lastname: Choi
authors.forename: J Stuart
authors.initials: JS
authors.lastname: Nelson
authors.forename: Alvin T
authors.initials: AT
authors.lastname: Yeh
mesh_terms: D000818:Animals; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D051381:Rats; D012031:Refractometry / Q000379:methods*; D012542:Scattering, Radiation; D012867:Skin / Q000737:chemistry* / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology*; D012995:Solubility; D013223:Statistics as Topic
chemical_list: D003879:Dermatologic Agents; D003094:Collagen