title: Plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus and impaired glucose tolerance.
abstract: Visfatin, a new adipokine, facilitates adipogenesis and has insulin-mimetic properties. We aimed to investigate the plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT), who had no obesity or hypertension. Twenty-two patients with T2DM, 18 subjects with IGT and 40 healthy controls were enrolled. Visfatin levels were measured along with the BMI, blood pressure, lipids, glucose, insulin, adiponectin and hsCRP levels, and HOMA-IR indexes. Age, sex and BMI were similar in all groups. Visfatin levels were higher in the diabetic group than the controls (p=0.01). There was no significant difference in the visfatin levels between the T2DM and IGT groups as well as IGT group and healthy controls. Plasma visfatin concentrations did not differ between men and women. Visfatin levels did not correlate with BMI, blood pressure, plasma adiponectin, insulin, hsCRP, glucose and lipid levels or HOMA-IR indexes in the three groups. These results indicate that hyperglycemia causes an increase in plasma visfatin levels and, as in people with T2DM but not with IGT, this increase gets more prominent as the glucose intolerance worsens.
authors.affiliation: Department of Internal Medicine, Gulhane School of Medicine, Etlik, Ankara, Turkey. teomandogru@yahoo.com
authors.forename: Teoman
authors.initials: T
authors.lastname: Dogru
authors.forename: Alper
authors.initials: A
authors.lastname: Sonmez
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: Ergun
authors.initials: E
authors.lastname: Bozoglu
authors.forename: Mahmut Ilker
authors.initials: MI
authors.lastname: Yilmaz
authors.forename: Halil
authors.initials: H
authors.lastname: Genc
authors.forename: Gokhan
authors.initials: G
authors.lastname: Erdem
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gok
authors.forename: Necati
authors.initials: N
authors.lastname: Bingol
authors.forename: Selim
authors.initials: S
authors.lastname: Kilic
authors.forename: Taner
authors.initials: T
authors.lastname: Ozgurtas
authors.forename: Sezin
authors.initials: S
authors.lastname: Bingol
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis*; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human