title: Multicentric glioblastoma multiforme in a patient with BRCA-1 invasive breast cancer.
abstract: Breast cancer is the most common cancer in women. Germline mutations in BRCA-1 and BRCA-2 significantly increase the risk of developing breast and ovarian cancers, and are also associated with an increased incidence of primary cancers at other sites. We report the case of a 46-year-old woman previously treated for ductal adenocarcinoma of the breast with BRCA-1 who subsequently was diagnosed with multicentric glioblastoma multiforme (GBM) in the right temporal and right occipital lobes. We briefly discuss the incidence of BRCA-1 mutations in breast cancer as well as other primary neoplasms and consider potential mechanisms shared in the pathogenesis of breast and glial tumors.
authors.affiliation: Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA.
authors.forename: Sarina B
authors.initials: SB
authors.lastname: Elmariah
authors.forename: Jason
authors.initials: J
authors.lastname: Huse
authors.forename: Bernard
authors.initials: B
authors.lastname: Mason
authors.forename: Peter
authors.initials: P
authors.lastname: Leroux
authors.forename: Robert A
authors.initials: RA
authors.lastname: Lustig
mesh_terms: D000368:Aged; D019313:BRCA1 Protein / Q000235:genetics*; D014408:Biomarkers, Tumor; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology; D005260:Female; D018095:Germ-Line Mutation; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology*; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008853:Microscopy; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology
chemical_list: D019313:BRCA1 Protein; D014408:Biomarkers, Tumor