title: Determination of the sildenafil effect on alopecia areata in childhood: An open-pilot comparison study.
abstract: BACKGROUND
  Alopecia areata is an immunologically mediated cessation of hair growth primarily involving, but not limited to, the scalp. The treatment of alopecia areata involves promotion of hair growth (for instance with topical minoxidil application), immunosuppression (intralesional or systemic steroid therapy, phototherapy) or immunomodulation (anthralin, dinitrochlorobenzene, diphenylcyclopropenone, squaric acid dibutylester). All these medications have some disadvantages and difficulties for the treatment of children with alopecia areata.
  
  
  OBJECTIVE
  To use an open-pilot study to assess the efficacy of topical 1% sildenafil in children diagnosed with alopecia areata.
  
  
  METHODS
  Eight patients with (25% of scalp surface area involvement) alopecia areata who were refractory to previous topical treatments applied 1% sildenafil twice daily for 3 months. All the patients completed the study.
  
  
  RESULTS
  Two patients experienced vellus-type hair growth and one patient had terminal hair growth. However, these outcomes were accepted as the spontaneous regression of the disease.
  
  
  CONCLUSIONS
  We cannot recommend the use of topical 1% sildenafil for the treatment of alopecia areata without further evidence of its therapeutic benefit.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Fatih University, Ankara, Turkey. evrenmd@yahoo.com
authors.forename: Evren
authors.initials: E
authors.lastname: Sarifakioglu
authors.forename: Ismail Tuncer
authors.initials: IT
authors.lastname: Degim
authors.forename: Canan
authors.initials: C
authors.lastname: Gorpelioglu
mesh_terms: D000293:Adolescent; D000506:Alopecia Areata / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate