[Abscopal effect on metastatic tumor induced by oncolytic virus of H101 combining with local heating].
OBJECTIVE
The abscopal effect on the tumors is a distant antitumor activity induced by local treatments. The study was to observe the induction of abscopal effect by the combination of H101 oncolytic virotherapy with local heating.


METHODS
Five patients with histologically confirmed, surgically unresectable metastatic malignant tumors (2 nasopharyngeal carcinomas, 1 pulmonary carcinoma, 1 parosteal sarcoma and 1 bladder carcinoma) that had definitely failed to the conventional chemotherapy and radiotherapy or refused these therapies were enrolled in this experimental therapy. All patients were treated with local intra tumor injection of H101 (5x10(11) - 15x10(11) VP) combined with 60-min heating at 42 degrees C.


RESULTS
Two patients were cured with complete regressions of both injected and non-injected tumors and have survived for a long period up to date. Three patients responded to the novel therapy variously and eventually died from the disease, who survived 29, 15 and 13 months, respectively.


CONCLUSIONS
The abscopal antitumor effect could be induced by the combination of H101 local intratumoral injection with heating.
Hu
Fang
F
Sunway Biotech Co., Ltd., Shanghai 200001, P. R. China. fanghu@sunwaybio.com.cn
Hu
Xiao-Hua
XH
Yu
Ping
P
Zhang
Jia-Xing
JX
Lou
Guo-Guang
GG
Liu
Hong-Li
HL
Wu
Bo
B
Zhao
Rong-Hua
RH
Xia
Hui-Qun
HQ
Wang
Yu
Y
Chen
Jie
J
Ben
Yong
Y
Chen
Si-Yi
SY
D000230:Adenocarcinoma / Q000556:secondary / Q000628:therapy; D000256:Adenoviridae / Q000235:genetics / Q000502:physiology; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000556:secondary / Q000628:therapy*; D002295:Carcinoma, Transitional Cell / Q000556:secondary / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000556:secondary / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D015552:Injections, Intralesional; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000235:genetics / Q000502:physiology*; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000628:therapy; D055815:Young Adult