Direct C-H arylation of (hetero)arenes with aryl iodides via rhodium catalysis.
A new method for the catalytic C-H arylation of heteroarenes and arenes that manifests high activity paired with reasonably broad scope was developed. Under the catalytic influence of RhCl(CO){P[OCH(CF3)2]3}2 and Ag2CO3, the direct C-H arylation of heteroarenes/arenes with aryl/heteroaryl iodides took place to afford a range of biaryls in good to excellent yields with high regioselectivity. Thiophenes, furans, pyrroles, indoles, and alkoxybenzenes are applicable in this arylation protocol.
Yanagisawa
Shuichi
S
Department of Chemistry and Research Center for Materials Science, Nagoya University, Nagoya 464-8602, Japan.
Sudo
Tomoko
T
Noyori
Ryoji
R
Itami
Kenichiro
K
D001555:Benzene Derivatives / Q000138:chemical synthesis*; D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D007462:Iodobenzenes / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D012238:Rhodium; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry
D001555:Benzene Derivatives; D005663:Furans; D006573:Heterocyclic Compounds, 1-Ring; D007462:Iodobenzenes; D011758:Pyrroles; D013876:Thiophenes; D012238:Rhodium