title: Antioxidant effects of hormone replacement therapy in postmenopausal women.
abstract: OBJECTIVE
  Postmenopausal women are more likely to develop coronary artery disease than premenopausal women of the same age. Postmenopausal oral oestrogen therapy is associated with increased levels of high-density lipoprotein (HDL) cholesterol and decreased levels of lowdensity lipoprotein (LDL) cholesterol. In this study we investigated the direct contribution of hormone replacement therapy on total antioxidant capacity rather than its effects on the serum lipid profile.
  
  
  METHODS
  At the time of enrolment and after the drug delivery plasma total cholesterol, triglycerides (TG), HDL, LDL, uric acid, total bilirubin, albumin, oestradiol levels and total antioxidant capacity of plasma were assessed.
  
  
  RESULTS
  Levels of plasma TG and total antioxidant capacity were significantly increased in the study group.
  
  
  CONCLUSIONS
  Our results suggest that oestrogen has an antioxidant effect following 3 months of hormone replacement therapy. Progesterone in combination with oestrogen does not have this effect. Also plasma TG levels increased in those patients receiving HRT after 3 months.
authors.affiliation: Ankara Numune Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey. tuncay@delibasi.net
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
authors.forename: Cem
authors.initials: C
authors.lastname: Kockar
authors.forename: Alper
authors.initials: A
authors.lastname: Celik
authors.forename: Olga
authors.initials: O
authors.lastname: Kockar
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood*
chemical_list: D000975:Antioxidants; D014280:Triglycerides; D011374:Progesterone; D002784:Cholesterol