title: Anesthesia for cesarean section in a patient with placenta previa and methylenetetrahydrofolate reductase deficiency.
abstract: We describe the anesthetic management of a patient with placenta previa presenting for a cesarean section, who had methylenetetrahydrofolate reductase (MTHFR) deficiency. Methylenetetrahydrofolate reductase deficiency increases homocysteine levels in the body and, therefore, predisposes to thrombosis. After a cerebrovascular accident at 8 weeks of gestational age, the patient received anticoagulants throughout the course of her pregnancy. Bleeding from the placenta previa occurred at 30 weeks of gestational age. Although general anesthesia was indicated for this patient because of her hemodynamic instability and an anticoagulated state, nitrous oxide is contraindicated in such patients. Thus, we chose a subarachnoid block because the patient remained hemodynamically stable, and anticoagulation had been stopped 8 hours before surgery. To our knowledge, there is no reported case of a parturient with MTHFR deficiency complicated with a cerebrovascular accident and associated with placenta previa presenting for a cesarean section. Anesthetic considerations are discussed in patients presenting with placenta previa associated with MTHFR deficiency.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Caritas St. Elizabeth's Medical Center, Boston, MA 02135-2997, USA. fredericgerges@yahoo.com
authors.forename: Frederic J
authors.initials: FJ
authors.lastname: Gerges
authors.forename: Aparna R
authors.initials: AR
authors.lastname: Dalal
authors.forename: Gary T
authors.initials: GT
authors.lastname: Robelen
authors.forename: Bronwyn
authors.initials: B
authors.lastname: Cooper
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Bayer
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000378:metabolism; D000328:Adult; D000773:Anesthesia, Obstetrical / Q000379:methods*; D002585:Cesarean Section; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000172:deficiency*; D010923:Placenta Previa / Q000601:surgery*; D011247:Pregnancy; D020521:Stroke / Q000209:etiology
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase