Successful treatment of prolonged agranulocytosis caused by acute parvovirus B19 infection with intravenous immunoglobulins.
A 21-year-old previously healthy male presented with prolonged fever of 3 weeks duration and profound agranulocytosis that did not respond to treatment with granulocyte-stimulating factors. A bone marrow biopsy demonstrated an absence of myeloid lineage. Acute parvovirus B19 infection was diagnosed by the presence of both IgM and IgG anti-parvovirus antibodies. Two days treatment with intravenous immunoglobulins (IVIg) resulted in complete recovery. The role of treatment with immunoglobulins in acute and persistent parvovirus infection is discussed.
Herzog-Tzarfati
K
K
Department "C" of Internal Medicine, Assaf Harofeh Medical Center, Zerifin 70300, Affiliated to Tel-Aviv University, Israel.
Shiloah
E
E
Koren-Michowitz
M
M
Minha
S
S
Rapoport
M J
MJ