title: Dicentric (17;20)(p11.2;q11.2): an uncommon cytogenetic abnormality in myeloid malignancies.
abstract: We report on two patients with myeloid disorders and complex karyotypes including a dicentric chromosome, dic(17;20)(p11.2;q11.2), resulting in the loss of most of 17p and 20q. The presence of the centromeres of chromosomes 17 and 20 in the dic(17;20), as well as the loss of TP53, were confirmed by fluorescence in situ hybridization. Deletions of 17p and 20q are recurrent abnormalities in hematologic disorders, particularly myelodysplastic syndrome and acute myeloid leukemia). However, a dic(17;20) is an uncommon finding. According to the few reports in the literature, dic(17;20) is associated with an unfavorable prognosis. The key mechanism might be the loss of TP53 as well as other tumor suppressor genes in 20q that may have a critical role in tumor genesis.
authors.affiliation: Laboratory of Cytogenetics, Quest Diagnostics Nichols Institute, 14225 Newbrook Drive, Chantilly, VA 20151, USA. carlos.a.tirado@questdiagnostics.com
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Tirado
authors.forename: Aurelia M
authors.initials: AM
authors.lastname: Meloni-Ehrig
authors.forename: Eian
authors.initials: E
authors.lastname: Wallenhorst
authors.forename: Kristine
authors.initials: K
authors.lastname: Burks
authors.forename: Jay
authors.initials: J
authors.lastname: Scheerle
authors.forename: Maurice
authors.initials: M
authors.lastname: Morillon
authors.forename: Joann C
authors.initials: JC
authors.lastname: Kelly
authors.forename: Deborah
authors.initials: D
authors.lastname: Heritage
authors.forename: Alexander
authors.initials: A
authors.lastname: Spira
authors.forename: Calvin D
authors.initials: CD
authors.lastname: Croft
authors.forename: Lewis
authors.initials: L
authors.lastname: Glasser
authors.forename: James N
authors.initials: JN
authors.lastname: Butera
authors.forename: Philip
authors.initials: P
authors.lastname: Mowrey
mesh_terms: D000208:Acute Disease; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents