Stem cell transplantation: potential impact on heart failure.
Cell transplantation is a promising new modality in treating damaged myocardium after myocardial infarction and in preventing postmyocardial infarction LV remodelling. Two strategies are plausible: the first uses adult tissue stem cells to replace the scar tissues and amend the lost myocardium, whilst the second strategy uses embryonic stem cells in an attempt to regenerate myocardium and/or blood vessels.
Ooi
Oon Cheong
OC
Department of Cardiac, Thoracic and Vascular Surgery, The Heart Institute, National Healthcare Group, National University Hospital, Singapore, Singapore.
Al Habib
Hamad F
HF
Almsherqi
Zakaria A
ZA
El Oakley
Reida M
RM
D053687:Adult Stem Cells / Q000166:cytology / Q000637:transplantation*; D002303:Cardiac Output, Low / Q000473:pathology / Q000628:therapy; D053595:Embryonic Stem Cells / Q000166:cytology / Q000637:transplantation*; D006321:Heart / Q000502:physiology; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D012038:Regeneration; D023822:Tissue Engineering