title: [Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury].
abstract: OBJECTIVE
  To explore the relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury.
  
  
  METHODS
  In 1:1 case-control study, 113 abnormal chromosome workers exposed to ionizing radiation were selected as cases and 113 normal chromosome as controls who matched with case for sex, age (+/- 5 years), nation, type of work, the same or more but in 2 years work length and the same similar levels of the cumulative exposure radiation dose. Genotypes were analysed using PCR based restriction fragment length polymorphism techniques.
  
  
  RESULTS
  The frequency of XRCC1 26304TT allele in case group (18.58%) was significantly higher than that in control group (7.08%), with OR for radiation damage being 3.47 (95% CI 1.43 - 8.44, P < 0.05). No association was observed between XRCC1 G27466A and G28152A and susceptibility to radiation injury.
  
  
  CONCLUSIONS
  The mutation of XRCC1 C26304T is related with the susceptibility to radiation injury. The polymorphisms of XRCC1 G27466A and G28152A are not found to have association with abnormal chromosomes.
authors.affiliation: Tangshan Center for Disease Control and Prevention, Tangshan, Hebei province 063000, China.
authors.forename: Liang-qun
authors.initials: LQ
authors.lastname: Wang
authors.forename: Xu-mei
authors.initials: XM
authors.lastname: Wu
authors.forename: Xue-yun
authors.initials: XY
authors.lastname: Fan
authors.forename: Jin-de
authors.initials: JD
authors.lastname: Yan
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: Bai
authors.forename: Ru-li
authors.initials: RL
authors.lastname: Li
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011832:Radiation Injuries / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human