title: FLT3/D835 mutation and inversion of chromosome 16 in leukemic transformation of myelofibrosis.
abstract: We present an atypical case of myelofibrosis developing into secondary leukemia FAB subtype M4, with inversion of chromosome 16, FLT3/D835 point mutation and diffuse osteolytic lesions accompanied by elevated TNF-alpha. The simultaneous occurrence of these mutations reflects the progressive association of genetic lesions developing into secondary leukemia with a relatively benign course.
authors.affiliation: Institute of Hematology, University Clinical Center, Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Colovic
authors.forename: Vladimir
authors.initials: V
authors.lastname: Jurisic
authors.forename: Sonja
authors.initials: S
authors.lastname: Pavlovic
authors.forename: Tatjana
authors.initials: T
authors.lastname: Terzic
authors.forename: Natasa
authors.initials: N
authors.lastname: Colovic