Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight.
TP-7 is a synthetic analogue of tuftsin. It has a structure of tuftsin, to which three natural L-amino-acids Pro-Gly-Pro are attached. This heptapeptide improves learning and memorization and causes antidepressant and anxiolytic effect. It is possible to use TP-7 in the future to optimize cognitive functions and as a potential new anxioselective, fast-acting and easy-dosed drug. Therefore, it was purposeful to study such properties of the heptapeptide as its influence on anxiety-fear and body weight under a long-term treatment regimen. The experiment was performed on 24 preselected Wistar rats with the use of Rodina's method. There were three experimental groups of animals with high initial emotional reactivity: passive control group (P), active control group (A, receiving distilled water) and group treated with TP-7 at the dose of 0.3 mg/kg (T). The rats of A and T groups received intraperitoneal injections every day. The experiments were conducted 15 min after the administration of the drug, one and two days after initial testing day, then 1, 2, 3 and 4 weeks after that. The heptapeptide reduced the anxiety-phobic states significantly starting from the second day of drug application. The observed effects persisted throughout four weeks of the experiment, which confirmed effective long-term anxiolytic properties of the heptapeptide. TP-7 did not cause any changes in the body mass by itself.
Czabak-Garbacz
Róza
R
Department of Human Physiology, Medical University of Lublin, Radziwiłłowska 11, PL 20-080 Lublin, Poland. czabak@am.lublin.pl
Cygan
Beata
B
Wolański
Lukasz
L
Kozlovsky
Igor
I
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D005239:Fear / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology* / Q000627:therapeutic use; D010698:Phobic Disorders / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D014405:Tuftsin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D009842:Oligopeptides; D014405:Tuftsin; C100827:TP 7