title: Promising molecular techniques for discriminating among follicular thyroid neoplasms.
abstract: To guide the extent of thyroidectomy for indeterminate follicular neoplasm (FN), clinicians have long sought ways to differentiate follicular adenoma from carcinoma pre- or intraoperatively. Several promising molecular techniques have recently appeared including loss of heterozygosity analysis and molecular profiling microarray analysis. These new tools may also prove useful in determining prognosis, thus and allow a paradigm change in current management of the thyroid nodule.
authors.affiliation: Department of Surgery, Section of Endocrine Surgery, University of Pittsburgh School of Medicine, 497 Scaife Hall, Pittsburgh PA 15261, USA.
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Carroll
authors.forename: Sally E
authors.initials: SE
authors.lastname: Carty
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000097:blood* / Q000175:diagnosis*; D000236:Adenoma / Q000097:blood* / Q000175:diagnosis*; D014408:Biomarkers, Tumor; D004252:DNA Mutational Analysis; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000097:blood* / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor