title: Pulse wave velocity is increased in patients with transient myocardial ischemia.
abstract: OBJECTIVE
  We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischemia who bear a high cardiovascular risk. Additionally we investigated whether arterial stiffness or wave reflection is the best indicator for transient myocardial ischemia. Aortic pulse wave velocity (PWV) is a measure of arterial stiffness, and augmentation index (AIx) an indication of arterial wave reflection. Both are indicators for cardiovascular risk.
  
  
  METHODS
  PWV (carotid-femoral) and AIx (SphygmoCor) were assessed in 74 hypertensive patients. Transient myocardial ischemia was detected using an ST-triggered 24-h ambulatory blood pressure monitoring device.
  
  
  RESULTS
  ST-segment depressions were recorded in 30 of 74 patients. There were no significant differences with regard to age, mean arterial pressure, systolic blood pressure, diastolic blood pressure or heart rate. PWV was seen to be higher in patients with transient myocardial ischemia (10.6 versus 9.5 m/s, P = 0.036). There was no significant difference in AIx between the two groups. PWV (r = 0.36, P = 0.002) but not AIx correlated with pulse pressure.
  
  
  CONCLUSIONS
  PWV is higher in hypertensive individuals (age > 60 years) with transient myocardial ischemia, suggesting that PWV is an indicator of increased cardiovascular risk. Although AIx is known to be associated with several cardiovascular diseases, it was not seen to be associated with silent myocardial ischemia. Our results suggest that the clinical significance of parameters of arterial stiffness and arterial wave reflection change with age, with a higher clinical importance of PWV indicated in patients over the age of 60.
authors.affiliation: Medizinische Poliklinik, University of Bonn, Germany bInstitute for Medical Statistics, University of Bonn, Germany. johannes.baulmann@ukb.uni-bonn.de
authors.forename: Johannes
authors.initials: J
authors.lastname: Baulmann
authors.forename: Rami
authors.initials: R
authors.lastname: Homsi
authors.forename: Sakir
authors.initials: S
authors.lastname: Uen
authors.forename: Rainer
authors.initials: R
authors.lastname: Düsing
authors.forename: Rolf
authors.initials: R
authors.lastname: Fimmers
authors.forename: Hans
authors.initials: H
authors.lastname: Vetter
authors.forename: Thomas
authors.initials: T
authors.lastname: Mengden
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002339:Carotid Arteries / Q000503:physiopathology; D016022:Case-Control Studies; D004548:Elasticity; D004562:Electrocardiography; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology*; D012307:Risk Factors