title: Lymphogranuloma venereum prevalence in Sweden among men who have sex with men and characterization of Chlamydia trachomatis ompA genotypes.
abstract: An outbreak of lymphogranuloma venereum (LGV) infections has recently been reported from The Netherlands and other European countries. The Swedish surveillance system has identified three LGV cases since 2004, all with clinically suspected infection in men who have sex with men (MSM). In order to assess the prevalence of LGV in a high-risk group of MSM and include clinically atypical cases, retrospective analysis of 197 Chlamydia trachomatis-infected men was performed. Sequencing of the ompA gene showed a different serotype distribution compared to recent Swedish studies in heterosexual populations. The most common types were G (45%), D (27%), and J (26%), whereas the normally predominant type E accounted for only 4% of the chlamydia cases. Furthermore, certain ompA genotype variants of the dominant serotypes were highly prevalent among MSM, and the reason for this is discussed. No additional case of LGV was detected by retrospective analysis of the high-risk MSM population. This indicates that, thus far, LGV in Sweden is only a result of sporadic import from infected MSM clusters abroad.
authors.affiliation: Department of Clinical Microbiology, Uppsala University Hospital, Sweden.
authors.forename: Markus
authors.initials: M
authors.lastname: Klint
authors.forename: Margareta
authors.initials: M
authors.lastname: Löfdahl
authors.forename: Carolina
authors.initials: C
authors.lastname: Ek
authors.forename: Asa
authors.initials: A
authors.lastname: Airell
authors.forename: Torsten
authors.initials: T
authors.lastname: Berglund
authors.forename: Björn
authors.initials: B
authors.lastname: Herrmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002692:Chlamydia trachomatis / Q000145:classification* / Q000235:genetics; D005838:Genotype; D018451:Homosexuality, Male; D006801:Humans; D008219:Lymphogranuloma Venereum / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D015995:Prevalence; D012703:Serotyping; D013548:Sweden
chemical_list: D001425:Bacterial Outer Membrane Proteins; C078167:OMPA outer membrane proteins