title: [MICA*008/A5.1 allele and HCMV infection in kidney transplanted donees of Hunan Han nationality].
abstract: OBJECTIVE
  To investigate the relationship between MICA*008/A5.1 allele and human cytomegalovirus (HCMV) infection in kidney transplanted donees of Hunan Han nationality.
  
  
  METHODS
  The MICA*008/A5.1 allele based on 91 kidney transplanted donees and 81 unrelated normal individuals of Han nationality in Hunan Province were analyzed by PCR/SSP assay. At the same time, anti-HCMV antibody IgM was detected in the serum by ELISA method.
  
  
  RESULTS
  The positive rate of MICA*008/A5.1 allele was significantly higher in the control group (56.79%) than that in the kidney transplanted donee group (34.07%) (P <0.05). The infection rate of HCMV in those individuals whose genotype was MICA*008/A5.1 (-) was significantly higher than that in the MICA*008/A5.1(+).
  
  
  CONCLUSIONS
  The individual whose genotype is MICA*008/A5.1 (+) is not liable to HCMV infection, but the individual whose genotype is MICA*008/A5.1 (-) is liable to HCMV infection.
authors.affiliation: Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
authors.forename: Bai-sheng
authors.initials: BS
authors.lastname: Huang
authors.forename: Qi-zhi
authors.initials: QZ
authors.lastname: Luo
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Mei
authors.forename: Yi-zhou
authors.initials: YZ
authors.lastname: Zou
authors.forename: Li-xiang
authors.initials: LX
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
mesh_terms: D000483:Alleles; D000914:Antibodies, Viral / Q000097:blood; D002681:China; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000235:genetics*; D005260:Female; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male
chemical_list: D000914:Antibodies, Viral; D015395:Histocompatibility Antigens Class I; D007075:Immunoglobulin M; C099187:MHC class I-related chain A