Lack of neuropeptide Y attenuates the somatic signs of opiate withdrawal.
Recent evidence suggests that neuropeptide Y (NPY) may be involved in the neurobiological responses to drugs of abuse. This study was designed to assess the possible contribution of NPY to opiate withdrawal behaviors. Here we report that mice lacking the NPY gene show normal conditioned place aversion to opiate withdrawal, but show attenuated opiate withdrawal somatic signs.
Olson
Valerie G
VG
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA. vgolson@u.washington.edu
Griner
Nicholas B
NB
Heusner
Carrie L
CL
Palmiter
Richard D
RD
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000235:genetics*; D005239:Fear / Q000187:drug effects / Q000502:physiology; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009020:Morphine / Q000009:adverse effects; D009043:Motor Activity / Q000187:drug effects / Q000235:genetics; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000009:adverse effects; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D009478:Neuropeptide Y / Q000235:genetics*; D009293:Opioid-Related Disorders / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D013375:Substance Withdrawal Syndrome / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology
D009292:Narcotic Antagonists; D009294:Narcotics; D009478:Neuropeptide Y; D009020:Morphine