title: The effects of proteins on the friction and lubrication of artificial joints.
abstract: The tribological testing of artificial hip and knee joints in the laboratory has been ongoing for several decades. This work has been carried out in an attempt to simulate the loading and motion conditions applied in vivo and, therefore, the potential for the success of the joint. However, several different lubricants have been used in these tests. The work documented in this paper compares results obtained using different lubricants and makes suggestions for future work. Hip joints and knee joints of different material combinations were tested in a friction simulator to determine their friction and lubrication properties. Both carboxymethyl cellulose (CMC) fluids and bovine serum (with CMC fluids added) were used as the lubricants. These were prepared to various viscosities to produce the Stribeck plots. Human synovial fluid, of just one viscosity, was used as the lubricant with some of the joints to give a true comparison with physiological lubricants. The results showed that, in most cases, the lubricant had a significant effect on the friction developed between the joint surfaces. This is thought to be due to the proteins that are present within the bovine serum adsorbing to the bearing surfaces, creating 'solid-like' films which rub together, protecting the surfaces from solid-to-solid contact. This would be beneficial in terms of wear but can either increase or decrease the friction between the contacting surfaces. It is important to simulate the conditions in vivo as closely as possible when testing these joints to try to obtain a better comparison between the joints and to simulate more accurately the way that these joints will operate in the body. In an attempt to simulate synovial fluid, bovine serum seems to be the most popular lubricant used at present. It would be beneficial, however, to develop a new synthetic lubricant that more closely matches synovial fluid. This would allow us to predict more accurately how these joints would operate long-term in vivo.
authors.affiliation: School of Engineering, Durham University, Durham, UK. s.c.scholes@durham.ac.uk
authors.forename: S C
authors.initials: SC
authors.lastname: Scholes
authors.forename: A
authors.initials: A
authors.lastname: Unsworth
mesh_terms: D001826:Body Fluids / Q000737:chemistry*; D019544:Equipment Failure Analysis; D017276:Friction; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008153:Lubrication; D011474:Prosthesis Design; D011506:Proteins / Q000737:chemistry*; D013582:Synovial Fluid / Q000737:chemistry*
chemical_list: D011506:Proteins