Regression of bilateral optic disc edema after discontinuation of amiodarone.
A 54-year-old non-obese woman treated with amiodarone reported blurred vision and had bilateral optic disc edema with relative preservation of visual function. Neurologic examination, brain imaging, and lumbar puncture opening pressures were normal, effectively ruling out increased intracranial pressure. Amiodarone was discontinued and the optic disc edema completely resolved over 15 months. In the absence of alternative explanations for the optic disc findings, amiodarone toxicity is suggested.
Shinder
Roman
R
Department of Ophthalmology, UMDNJ-NJMS, Newark, New Jersey, USA.
Frohman
Larry P
LP
Turbin
Roger E
RE
D000638:Amiodarone / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D010211:Papilledema / Q000209:etiology* / Q000473:pathology; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000473:pathology; D013997:Time Factors; D014665:Vasodilator Agents / Q000009:adverse effects*
D014665:Vasodilator Agents; D000638:Amiodarone