title: Non-surgical treatment for detrusor overactivity.
abstract: Urinary incontinence is a common but under-reported condition. Approximately 17% of women are affected by detrusor overactivity at some time in their lives. Pharmacological treatment of this condition used to be severely limited by the side-effects of the drugs and the associated poor patient compliance. Recently, however, the tolerability and effectiveness of pharmacotherapy have been improved by the introduction of new drugs and alternative methods of drug delivery. This review assesses the effectiveness and tolerability of these new treatments. Anticholinergic agents, botulinum toxin and neuromodulation are also discussed.
authors.affiliation: Women's Centre, John Radcliffe Hospital, Oxford, UK. alexslack@ukonline.co.uk
authors.forename: R Alexander
authors.initials: RA
authors.lastname: Slack
authors.forename: Simon
authors.initials: S
authors.lastname: Jackson
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D014549:Urinary Incontinence / Q000628:therapy*
chemical_list: D018680:Cholinergic Antagonists; D019274:Botulinum Toxins, Type A