title: [Current and future approaches for the treatment of inflammatory diseases of inferior respiratory tract].
abstract: Among the allergic disorders we emphasize the inflammatory diseases of the inferior respiratory tract by their incidence, repercussion in daily activities, and by their high cost of medical attention. For their treatment, they require more than one inhaled or systemic drug. Current medicines tend to have adverse or secondary effects, such as: osteoporosis, type 3 diabetes mellitus, tremor or tachycardia. New medicines are being developed with less adverse or secondary effects, and much more selective and specific in the molecules involved in the allergic disease's physiopathology. Among them we find pascolizumab, which inhibits the differentiation made to Th2, as well as the citokines production. Other drugs are: mepolizumab, monoclonal antibody antiCD23, and the selective inhibitor of IgE (AJP13358) Rhu-Mab-E25. Currently, they are being developed some new drugs, such as SB-207499 (SKB) and LAS 31025, which are selective inhibitors of fosfodiesterase. Within the currently studied medicines that offer high specificity to inhibit the synthesis of interleukines we emphasize the presence of humanized monoclonal antibodies antireceptor IL-4. The anti IL-5 (SB-240563) is administered in asthmatic patients to reduce eosinofilia in expectoration. Tosilate of suplatast is a selective IL-4 and IL-5 inhibitor. Ramatroban (BAY or 3405) is an antagonist of the tromboxane A2 receptor, which reduces the inflammatory process of the nasal mucose without hemodynamic effects. Immunotherapy with peptides avoids the response of IgE by the allergen, without mast cell degranulation.
authors.affiliation: Alergólogo e inmunólogo clínico, Centro Médico Nacional Siglo XXI, IMSS. gaguitos@yahoo.com
authors.forename: Guillermo Arturo
authors.initials: GA
authors.lastname: Guidos Fogelbach
authors.forename: Jorge Gabriel
authors.initials: JG
authors.lastname: Rodríguez Velasco
authors.forename: Victor Manuel
authors.initials: VM
authors.lastname: Almeida Arvizu
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D005544:Forecasting; D006801:Humans; D007167:Immunotherapy; D012130:Respiratory Hypersensitivity / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal