Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV.
Genotype E hepatitis B virus (HBV) was detected in two Argentine sisters exhibiting an African mitochondrial lineage. One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A HBsAg escape mutant without anti-HBs antibodies. Both sisters carried an unusual L209V substitution within HBsAg.
Mathet
Verónica L
VL
Departamento Microbiología, Centro para el Estudio de Hepatitis Virales, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 Piso 11, 1121 Buenos Aires, Argentina.
Cuestas
María L
ML
Ruiz
Vanesa
V
Minassian
María L
ML
Rivero
Cintia
C
Trinks
Julieta
J
Daleoso
Graciela
G
León
Liliana M
LM
Sala
Andrea
A
Libellara
Beatriz
B
Corach
Daniel
D
Oubiña
José R
JR
D000293:Adolescent; D000328:Adult; D001118:Argentina; D044383:Black People; D002353:Carrier State / Q000821:virology; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D009154:Mutation; D010802:Phylogeny; D014611:Vaccination
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines