title: [Coma in a child after treatment with the 'magic salve' lidocaine-prilocaine cream].
abstract: A 2-year-old girl lost consciousness after the topical application of lidocaine-prilocaine cream (EMLA) in preparation for the removal of multiple mollusca contagiosa. Both the area on which cream was applied (80% of body surface) and the total amount of cream (90 g) exceeded the maximum dosage. Lidocaine-prilocaine cream is a widely used local anaesthetic with few side effects when used properly. Intoxication with a lidocaine-prilocaine preparation may have serious consequences, such as changes in intracardiac conduction, excitation or depression of the central nervous system and methaemoglobinaemia. In our patient both methaemoglobinaemia and depression of the central nervous system occurred, resulting in loss of consciousness. She was treated with 100% oxygen and fully recovered.
authors.affiliation: Spaarne Ziekenhuis, afd. Kindergeneeskunde, Postbus 770, 2130 AT Hoofddorp.
authors.forename: J W
authors.initials: JW
authors.lastname: Wieringa
authors.forename: A G
authors.initials: AG
authors.lastname: Ketel
authors.forename: M A
authors.initials: MA
authors.lastname: van Houten
mesh_terms: D000779:Anesthetics, Local / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D003128:Coma / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects* / Q000627:therapeutic use; D000077442:Lidocaine, Prilocaine Drug Combination; D008976:Molluscum Contagiosum / Q000601:surgery; D009824:Ointments; D010100:Oxygen / Q000627:therapeutic use*; D011318:Prilocaine / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D008012:Lidocaine; D010100:Oxygen