title: Simulations of localized harmonic motions on a blood vessel wall induced by an acoustic radiation force used in ultrasound elastography.
abstract: Many noninvasive techniques have been developed recently to explore the mechanical properties of soft tissue. In this paper, dynamic acoustic radiation force induced vibrations on a blood vessel wall were simulated using different stimulation frequencies and stiffness parameters for the vessel wall. The stimulation frequency was varied between 20 Hz and 20 kHz and the stiffness parameter (Young's modulus) was varied between 60 kPa and 360 kPa. The vibration simulations were computed using a finite-element method in a 3D geometry that contained a vessel wall surrounded by soft tissue. The results indicate that vibrations caused by acoustic stimulation are sensitive to the changes in mechanical properties of the vessel wall and that the vibrations are highly dependent on the stimulation frequency and target structure. Therefore, measurements of absolute stiffness parameters may not be accurately achieved because this method is so dependent on the whole target structure, whereas the monitoring of changes during some process may be feasible.
authors.affiliation: Department of Applied Physics, University of Kuopio, 70211 Kuopio, Finland. Janne.Heikkila@uku.fi
authors.forename: Janne
authors.initials: J
authors.lastname: Heikkilä
authors.forename: Tero
authors.initials: T
authors.lastname: Karjalainen
authors.forename: Marko
authors.initials: M
authors.lastname: Vauhkonen
authors.forename: Kullervo
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001808:Blood Vessels / Q000473:pathology*; D003198:Computer Simulation; D004548:Elasticity; D005240:Feasibility Studies; D020342:Finite Element Analysis; D008954:Models, Biological; D009038:Motion; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods; D013314:Stress, Mechanical; D014465:Ultrasonics; D014463:Ultrasonography / Q000379:methods*; D014783:Viscosity