AKT in thyroid tumorigenesis and progression.
AKT (protein kinase B) is a central signaling molecule in the phosphatidyl inositol 3-kinase pathway that is frequently activated in human cancer. AKT activation regulates energy metabolism, apoptosis, proliferation, and migration in many cell systems. In thyroid cancer, AKT activation is involved in tumorigenesis, particularly in both inherited and sporadic forms of follicular thyroid cancer. Phosphatidyl inositol 3-kinase and AKT signaling also appear to play an important role in progression of both papillary and follicular cancers. In this review, the role of AKT in thyroid cancer development and progression are discussed with a focus on areas of current debate in the literature.
Shinohara
Motoo
M
Divisions of Endocrinology and Oncology, The Ohio State University College of Medicine, 1581 Dodd Drive, Columbus, OH 43210, USA.
Chung
Yun Jae
YJ
Saji
Motoyasu
M
Ringel
Matthew D
MD
D000818:Animals; D002291:Carcinoma, Papillary / Q000209:etiology* / Q000378:metabolism; D018265:Carcinoma, Papillary, Follicular / Q000209:etiology / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D008954:Models, Biological; D051058:Oncogene Protein v-akt / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000378:metabolism
D051058:Oncogene Protein v-akt