Brief report: no evidence for parvovirus B19 or hepatitis E virus as a cause of acute liver failure.
Viral hepatitis A and B are known to cause acute liver failure. While nearly 20% of acute liver failure cases are of indeterminate etiology, screening for other viruses has not been uniformly performed. We looked for evidence for parvovirus B19 and hepatitis E virus in sera from U.S. acute liver failure patients. For B19, 78 patients' sera, including 34 with indeterminate etiology, were evaluated by DNA dot-blot hybridization, reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay for immunoglobin G and M antibodies; none showed evidence for infection.
Lee
W M
WM
Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8887, USA. William.Lee@utsouthwestern.edu
Brown
K E
KE
Young
N S
NS
Dawson
G J
GJ
Schlauder
G G
GG
Gutierrez
R A
RA
Fontana
R
R
Rossaro
L
L
Davern
T
T
Lalani
E
E
D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood*; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D017114:Liver Failure, Acute / Q000097:blood* / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology; D012367:RNA, Viral / Q000097:blood*
D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral