Levetiracetam-induced myoclonic status epilepticus in myoclonic-astatic epilepsy: a case report.
We report on a 3-year-old boy with myoclonic-astatic epilepsy who developed myoclonic status epilepticus with continuous twitching of the face and unresponsiveness under monotherapy with levetiracetam. Recently, a nonconvulsive status epilepticus in an adult epilepsy patient has also been described. Our observation points to the possibility of a causal relationship between the induction of myoclonic status by levetiracetam in certain patients with Doose's syndrome. However, a spontaneous evolution cannot be excluded. Levetiracetam is a well-known drug for the control of myoclonic seizures. A controlled study would provide a better understanding of any possible aggravating role in certain forms of myoclonic-astatic epilepsy.
Kröll-Seger
Judith
J
Paediatric Department, Swiss Epilepsy Centre, Zurich, Switzerland. judith.kroell@swissepi.ch
Mothersill
Ian William
IW
Novak
Simon
S
Sälke-Kellermann
Ritva Anneli
RA
Krämer
Günter
G
D000927:Anticonvulsants / Q000009:adverse effects*; D001519:Behavior; D002675:Child, Preschool; D004569:Electroencephalography; D004576:Electromyography; D004831:Epilepsies, Myoclonic / Q000139:chemically induced*; D005013:Ethosuximide / Q000627:therapeutic use; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives*; D013226:Status Epilepticus / Q000139:chemically induced*
D000927:Anticonvulsants; D000077287:Levetiracetam; D005013:Ethosuximide; D010889:Piracetam