title: Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.
abstract: Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic neuron depletion; ALS, a disease of motor neuron death; and Alzheimer's, a disease of plaques and tangles. Although these disorders differ in important ways, they also have common pathogenic features, including inflammation, genetic mutations, inappropriate protein aggregates (e.g., Lewy bodies, amyloid plaques), and biochemical defects leading to apoptosis, such as oxidative stress and mitochondrial dysfunction. In most disorders, it remains uncertain whether inflammation and protein aggregation are neurotoxic or neuroprotective. Elucidating the mechanisms that orchestrate neuronal diseases should facilitate development of neuroprotective and neurorestorative strategies.
authors.affiliation: UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, and The Cleveland Clinic, OH, USA. jalbutsu@umdnj.edu
authors.forename: Suhayl
authors.initials: S
authors.lastname: Dhib-Jalbut
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Arnold
authors.forename: Don W
authors.initials: DW
authors.lastname: Cleveland
authors.forename: Mark
authors.initials: M
authors.lastname: Fisher
authors.forename: Robert M
authors.initials: RM
authors.lastname: Friedlander
authors.forename: M Maral
authors.initials: MM
authors.lastname: Mouradian
authors.forename: Serge
authors.initials: S
authors.lastname: Przedborski
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Trapp
authors.forename: Tony
authors.initials: T
authors.lastname: Wyss-Coray
authors.forename: V Wee
authors.initials: VW
authors.lastname: Yong
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D000818:Animals; D020170:Caspase 1 / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000209:etiology* / Q000276:immunology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D020521:Stroke / Q000188:drug therapy
chemical_list: D018696:Neuroprotective Agents; D020170:Caspase 1