title: Novel nucleotide triphosphates as potent P2Y2 agonists.
abstract: The synthesis and P2Y2 activities of a novel series of nucleoside triphosphates are described. Many of these compounds were potent agonists of the P2Y2 receptor.
authors.affiliation: UCB-Group, Granta Park, Abington, Cambridge CB1 6GS, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Brookings
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Davenport
authors.forename: Jeremy
authors.initials: J
authors.lastname: Davis
authors.forename: Frances C A
authors.initials: FC
authors.lastname: Galvin
authors.forename: Steve
authors.initials: S
authors.lastname: Lloyd
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Mack
authors.forename: Ray
authors.initials: R
authors.lastname: Owens
authors.forename: Verity
authors.initials: V
authors.lastname: Sabin
authors.forename: Joanne
authors.initials: J
authors.lastname: Wynn
mesh_terms: D045744:Cell Line, Tumor; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009711:Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology*; D058910:Purinergic P2 Receptor Agonists; D058473:Receptors, Purinergic P2Y2; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013329:Structure-Activity Relationship; D014544:Uridine Triphosphate / Q000494:pharmacology
chemical_list: D018076:DNA, Complementary; D007202:Indicators and Reagents; D009711:Nucleotides; C546385:P2RY2 protein, human; D058910:Purinergic P2 Receptor Agonists; D058473:Receptors, Purinergic P2Y2; D014544:Uridine Triphosphate