title: Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol.
abstract: A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.
authors.affiliation: Department of Nuclear Medicine and Institute of Radiation Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Jongno-gu, Seoul 110-744, Korea.
authors.forename: Yun-Sang
authors.initials: YS
authors.lastname: Lee
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Jeong
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Kim
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Chang
authors.forename: Hak Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Miwon
authors.initials: M
authors.lastname: Son
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Heung Sik
authors.initials: HS
authors.lastname: Yoon
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Kang
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: June-Key
authors.initials: JK
authors.lastname: Chung
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Lee
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
mesh_terms: D000107:Acetylation; D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007459:Iodized Oil / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods; D008657:Metabolic Clearance Rate; D051379:Mice; D009928:Organ Specificity; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use; D011933:Reagent Kits, Diagnostic; D014018:Tissue Distribution
chemical_list: C498051:188Re-4-hexadecyl-1,2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol lipiodol conjugate; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D011933:Reagent Kits, Diagnostic; D007459:Iodized Oil