Chaetocochins A-C, epipolythiodioxopiperazines from Chaetomium cochliodes.
Three new epipolythiodioxopiperazines, chaetocochins A (1), B (2), and C (3), along with dethio-tetra (methylthio) chetomin (4) and chetomin (5), were isolated from the ethyl acetate extract of the solid-state fermented rice culture of the fungus Chaetomium cochliodes. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1, 3, and 4 exhibited significant cytotoxicity in vitro against cancer cell lines Bre-04, Lu-04, and N-04.
Li
Guo-You
GY
Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
Li
Bo-Gang
BG
Yang
Tao
T
Yan
Ju-Fang
JF
Liu
Guang-Ye
GY
Zhang
Guo-Lin
GL
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012275:Oryza / Q000382:microbiology*; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; D010879:Piperazines; C514415:chaetocochin A; C514416:chaetocochin B; C514417:chaetocochin C