Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults.
The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag-time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic difference was minor and presumably of no clinical relevance.
Osterberg
Ole
O
Ferring Pharmaceuticals A/S, Kay Fiskers Plads 11 DK-2300 Copenhagen S, Denmark.
Savic
Radojka M
RM
Karlsson
Mats O
MO
Simonsson
Ulrika S H
US
Nørgaard
Jens Peter
JP
Walle
Johan Vande
JV
Agersø
Henrik
H
D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000465:Algorithms; D050034:Antidiuretic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001682:Biological Availability; D002648:Child; D018592:Cross-Over Studies; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005612:Freeze Drying; D006801:Humans; D007408:Intestinal Absorption; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008954:Models, Biological; D053206:Nocturnal Enuresis / Q000188:drug therapy* / Q000378:metabolism; D014018:Tissue Distribution
D050034:Antidiuretic Agents; D004304:Dosage Forms; D003894:Deamino Arginine Vasopressin