Successful treatment with oral valganciclovir in immunocompetent infant with gastrointestinal manifestations of cytomegalovirus infection.
A 3-month-old male infant was admitted to hospital with anemia. Follow-up controls revealed the presence of specific cytomegalovirus (CMV) antibodies. Virus was isolated from urine, blood, and saliva. At 7 months of age, he presented with melena. Polymerase chain reaction (PCR) of biopsy samples from the duodenum was positive for CMV. Anemia resolved after starting antiviral therapy with oral valganciclovir.
Buonuomo
P S
PS
Division of Pediatric Oncology, Department of Paediatrics, Università Cattolica del Sacro Cuore, Policlinico A Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy. savabi@libero.it
Maurizi
P
P
Valentini
P
P
Mastrangelo
S
S
Lazzareschi
I
I
Ridola
V
V
Riccardi
R
R
D000740:Anemia / Q000821:virology*; D000998:Antiviral Agents / Q000627:therapeutic use*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D003937:Diagnosis, Differential; D015774:Ganciclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D008551:Melena / Q000821:virology; D000077562:Valganciclovir
D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir