Movement-related cortical activation in familial Parkinson disease.
We sought to determine whether or not first-degree relatives of patients with familial Parkinson disease (FDRs) present impaired movement-related cortical activity. We studied 10 familial Parkinson disease subjects, 10 FDRs, and 10 controls and analyzed event-related mu desynchronization (ERD) and beta synchronization. Forty percent FDRs presented reduced premovement mu ERD latency, suggesting that premovement cortical activation is impaired in FDRs.
Delval
A
A
Department of Clinical Neurophysiology, Hospital R. Salengro, Regional University Hospital, Lille, France.
Defebvre
L
L
Labyt
E
E
Douay
X
X
Bourriez
J-L
JL
Waucquiez
N
N
Derambure
P
P
Destée
A
A
D000368:Aged; D003344:Cortical Synchronization / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009069:Movement Disorders / Q000503:physiopathology*; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology