title: [The study of the in vivo-in vitro correlation of the naftopidil sustained-release tablet in dog].
abstract: We studied the correlation of sustained-release tablet of naftopidil between the in vitro release and the in vivo absorption in the dog. The release rate (X) of naftopidil sustained-release tablet in artificial gastric fluid was determined and the naftopidil concentration in plasma was determined after a single oral dose of 100 mg naftopidil (tablet or sustained-release tablet) in the dog. The absorbed fraction(F) and in vivo absorption rate (A) of the NAF sustained-release tablet in the dog at different time were calculated by W-N method and deconvolution method, respectively. Then the regression equations between F or A and X of the corresponding time point were obtained: F=2. 1533X - 27. 636(r = 0.9927) and A=2.3452X - 25.474(r= 0.9938). W-N method and deconvolution method both indicated that the correlation between the in vitro release and the in vivo absorption in the dog of the NAF sustained-release tablet was good.
authors.affiliation: Children's Hospital, Chongqing Medical University, Chongqing 400014, China.
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Jia
authors.forename: Xuehua
authors.initials: X
authors.lastname: Jiang
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ding
mesh_terms: D000818:Animals; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004285:Dogs; D009281:Naphthalenes / Q000737:chemistry / Q000493:pharmacokinetics*; D010879:Piperazines / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D009281:Naphthalenes; D010879:Piperazines; D013607:Tablets; C064357:naftopidil