title: Value of carcinoembryonic antigen assay in predicting hepatic metastases, local recurrence, and survival after curative resection of colorectal cancer.
abstract: OBJECTIVE
  We measured carcinoembryonic antigen (CEA) levels in peripheral and portal venous blood, and bile from patients with colorectal cancer, to determine its role in predicting hepatic metastases, local recurrence, and survival.
  
  
  METHODS
  The subjects were 73 patients who underwent curative surgery for colorectal cancer.
  
  
  RESULTS
  The median serum, bile, and portal CEA levels were significantly lower in 5-year survivors than in patients in whom hepatic metastases or recurrent disease subsequently developed. The CEA level in portal blood and bile was a good indicator of hepatic metastases, with sensitivity of 92% and 100%, respectively. However, the accuracy of any CEA measurement for predicting hepatic metastases, local recurrence, or 5-year survival did not exceed 70%.
  
  
  CONCLUSIONS
  None of these CEA measurements is accurate enough to be the basis of a management decision. Thus, we suggest that CEA measurement be used to assist in the prediction of a high risk of the development of hepatic secondaries and that these patients are followed up closely after curative resection.
authors.affiliation: Fourth Surgical Department, Aristotle University of Thessaloniki, G. Papanikolaou General Regional Hospital, 57010 Exohi, Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kanellos
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Zacharakis
authors.forename: Haralampos
authors.initials: H
authors.lastname: Demetriades
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Christoforidis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kanellos
authors.forename: Manousos-Georgios
authors.initials: MG
authors.lastname: Pramateftakis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Betsis
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000097:blood / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000401:mortality*; D011379:Prognosis; D011863:Radioimmunoassay; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen