title: Spontaneous polymorphic ventricular tachycardia after administration of pilsicainide in a patient resuscitated from ventricular fibrillation.
abstract: We performed a pilsicainide challenge test in a 38-year-old man who was resuscitated from ventricular fibrillation without apparent baseline electrocardiogram (ECG) abnormality. His father had a history of ventricular fibrillation and his brother had multiple episodes of syncope. Pilsicainide (1 mg/kg) induced short coupled ventricular premature beats followed by repetitive polymorphic ventricular tachycardia without apparent J wave and ST elevation, and excessive changes in QRS duration and QT interval. An implantable cardioverter defibrillator was implanted.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. kamefu@rb3.so-net.ne.jp
authors.forename: Tsuneaki
authors.initials: T
authors.lastname: Sadanaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Araki
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D004554:Electric Countershock; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000031:analogs & derivatives*; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000517:prevention & control*; D014693:Ventricular Fibrillation / Q000150:complications* / Q000628:therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; C042288:pilsicainide