Cognitive impairment of acute onset in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) study: occurrence, correlates, and outcomes.
OBJECTIVE
Having demonstrated that dementia of acute onset represents a distinct syndrome with distinct outcomes, the authors investigated whether similar attributes describe cognitive impairment of acute onset (CIAO).


METHODS
The authors conducted a secondary analysis of the Consortium to Investigate Vascular Impairment of Cognition study.


RESULTS
Ninety patients met our criteria for CIAO. Compared with cognitive impairment of gradual onset, CIAO was associated with vascular features (odds ratio [OR]: 12.3, 95% confidence interval [CI]: 3.2-47.9), dementias other than Alzheimer disease (OR: 6.5, 95% CI: 2.1-20.8), and decreased survival (hazard ratio: 2.8, 95% CI: 1.6-4.6).


CONCLUSIONS
Patients with CIAO are clinically identifiable and have distinct outcomes.
King
Paige
P
Division of Geriatric Medicine, Dalhousie University, Canada.
Song
Xiaowei
X
Rockwood
Kenneth
K
D000208:Acute Disease; D017668:Age of Onset; D000368:Aged; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000628:therapy*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D015331:Cohort Studies; D006801:Humans; D009483:Neuropsychological Tests; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome