Factor V inhibitor: case report.
Acquired inhibitors to coagulation factors are rare, certainly those directed against factor V. A total of around 150 cases have so far been reported, of which the greater part was due to bovine thrombin exposure. We report the case of a patient who developed a factor V inhibitor during a postoperative period. This report describes possible aetiologies, varying clinical conditions and treatment possibilities as described in the literature. Furthermore, this case report is an example of the often unpredictable disease progression in a patient with existence of a factor V inhibitor.
Leus
Barbara
B
Clinical Laboratory, General Hospital Middelheim, Antwerp, Belgium. barbaraleus@hotmail.com
Devreese
Katrien
K
van den Bossche
Jan
J
Malfait
Ronald
R
D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001780:Blood Coagulation Tests; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects; D018450:Disease Progression; D005165:Factor V / Q000037:antagonists & inhibitors* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D020300:Intracranial Hemorrhages / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008171:Lung Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D008297:Male; D011183:Postoperative Complications; D047090:beta-Lactams / Q000008:administration & dosage / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D047090:beta-Lactams; D002939:Ciprofloxacin; D005165:Factor V