title: Italian Multiple Sclerosis Database Network.
abstract: The Multiple Sclerosis Database Network (MSDN) is the first Italian multiple sclerosis (MS) registry. The preliminary results on the MSDN cohort demonstrated that the risk of disability progression, in a sample of 2090 MS patients, was reduced by about four- to five-fold in patients exposed to IFNbeta for more than 4 years compared with patients exposed for up to 2 years. More recent results showed, in a subset of 1170 relapsing-remitting MS patients, of whom 918 were treated with IFNbeta and 252 were untreated, that IFNbeta-treated patients had a differential reduction in EDSS score change of -0.055 for each year of follow-up in comparison with the untreated group. These results provide significant information on the effectiveness of IFNbeta treatment on long-term disability progression in MS.
authors.affiliation: Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I-70124 Bari, Italy. mtrojano@neurol.uniba.it
authors.forename: M
authors.initials: M
authors.lastname: Trojano
authors.forename: D
authors.initials: D
authors.lastname: Paolicelli
authors.forename: V
authors.initials: V
authors.lastname: Lepore
authors.forename: A
authors.initials: A
authors.lastname: Fuiani
authors.forename: E
authors.initials: E
authors.lastname: Di Monte
authors.forename: F
authors.initials: F
authors.lastname: Pellegrini
authors.forename: P
authors.initials: P
authors.lastname: Russo
authors.forename: P
authors.initials: P
authors.lastname: Livrea
authors.forename: G
authors.initials: G
authors.lastname: Comi
mesh_terms: D003195:Computer Communication Networks; D016208:Databases, Factual / Q000706:statistics & numerical data*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D007558:Italy / Q000453:epidemiology; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D016899:Interferon-beta