[Study on the epidemiology and etiologic agent of Dengue fever outbreaks in Fuzhou in 2004].
OBJECTIVE
To study the epidemiology and etiologic characteristics of a Dengue fever outbreak in Fuzhou from the beginning of September to the end of October in 2004 in order to understand the source of infection.


METHODS
Data on descriptive epidemiology was collected to study the characteristics and related factors to the epidemic. Dengue virus was isolated through the use of C6/36 cell line while viral serotypes were identified by indirect immunofluorecent assay with type-specific monoclonal antibody. The sources of infection were traced by nucleotide sequencing.


RESULTS
During the epidemic, 93 cases occured consistently with the region entomoplily growth and decay. The viruses of 6 strains isolated from 10 patients' blood specimens were identified as dengue virus type 1. Phylogenetic evidence suggested that the viral isolate had high genetic relation with the isolates from Kampuchea (DENV-1/KHM/2001; GenBank Accession No. L0904278).


CONCLUSIONS
The epidemic was caused by introduction of patients migrating into Fuzhou.
Yan
Yan-sheng
YS
Fujian Centers for Disease Control and Prevention, Fuzhou 350001, China.
Hong
Ront-tao
RT
Shen
Xiao-na
XN
Weng
Yu-wei
YW
Cai
Shao-jian
SJ
Xu
Bao-hai
BH
Li
Shi-qing
SQ
He
Jia-xin
JX
Xu
Long-shan
LS
Lin
Yun-qing
YQ
Zheng
Neng-xiong
NX
Lin
Mao
M
Lin
Shu-hua
SH
D002681:China / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology*; D003716:Dengue Virus / Q000235:genetics* / Q000302:isolation & purification; D004196:Disease Outbreaks; D004641:Emigration and Immigration; D014644:Genetic Variation; D006801:Humans; D010802:Phylogeny