title: Proteome informatics II: bioinformatics for comparative proteomics.
abstract: The present review attempts to cover the most recent initiatives directed towards representing, storing, displaying and processing protein-related data suited to undertake "comparative proteomics" studies. Data interpretation is brought into focus. Efforts invested into analysing and interpreting experimental data increasingly express the need for adding meaning. This trend is perceptible in work dedicated to determining ontologies, modelling interaction networks, etc. In parallel, technical advances in computer science are spurred by the development of the Web and the growing need to channel and understand massive volumes of data. Biology benefits from these advances as an application of choice for many generic solutions. Some examples of bioinformatics solutions are discussed and directions for on-going and future work conclude the review.
authors.affiliation: Proteome Informatics Group, Swiss Institute of Bioinformatics, Geneva, Switzerland. frederique.lisacek@isb-sib.ch
authors.forename: Frédérique
authors.initials: F
authors.lastname: Lisacek
authors.forename: Sarah
authors.initials: S
authors.lastname: Cohen-Boulakia
authors.forename: Ron D
authors.initials: RD
authors.lastname: Appel
mesh_terms: D000465:Algorithms; D001331:Automation; D002853:Chromatography, Liquid; D019295:Computational Biology / Q000295:instrumentation / Q000379:methods*; D003627:Data Interpretation, Statistical; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D007091:Image Processing, Computer-Assisted; D020407:Internet; D013058:Mass Spectrometry; D010455:Peptides / Q000737:chemistry; D011381:Programming Languages; D040901:Proteomics / Q000295:instrumentation / Q000379:methods*; D011786:Quality Control; D012984:Software
chemical_list: D010455:Peptides