Suprasellar and intrasellar paragangliomas.
Neoplasms of the sellar region are entities with a large differential diagnosis. Although paraganglionic cells have not been demonstrated in the pituitary or adjacent structures, the existence of sellar region paragangliomas is well-documented. To elucidate, in this area the nature of these unusual tumors is relatively difficult. Clinical history, physical examination, radiographic investigation as well as intraoperative gross observation are the same as those of sellar meningioma or pituitary adenoma. Immunohistochemistry, using neuroendocrine markers and electron microscopy are the two definitive diagnostic methods to differentiate among these entities. The clinical management, the possible pathogenesis of the tumor, the importance of immunohistochemistry in making the diagnosis and the clinical outcome of these patients are discussed.
Voulgaris
S G
SG
University of Ioannina Medical School, Regional University Hospital of Ioannina, Department of Neurosurgery, Ioannina 45110, Greece. iliaspessach1980@yahoo.gr
Partheni
M
M
Tzortzidis
F
F
Ravazoula
P
P
Pessach
I S
IS
Papadakis
N
N
Polyzoidis
K S
KS
D000236:Adenoma / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003397:Craniopharyngioma / Q000473:pathology; D003919:Diabetes Insipidus / Q000209:etiology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006261:Headache / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects; D010235:Paraganglioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014786:Vision Disorders / Q000209:etiology