Efficient nitro-aldol reaction using SmI2: a new route to nitro alcohols under very mild conditions.
A novel method to obtain racemic 1-nitroalkan-2-ols by reaction of bromonitromethane with a variety of aldehydes and promoted by SmI2 is reported. On the basis of these results, the chiral version has also been performed with chiral N,N-dibenzyl amino aldehydes, affording the corresponding enantiopure 3-amino-1-nitroalkan-2-ols with good stereoselectivity.
Concellón
José M
JM
Departamento de Química Organica e Inorganica, Facultad de Química, Universidad de Oviedo, Julian Clavería 8, 33071 Oviedo, Spain. jmcg@fq.uniovi.es
Rodríguez-Solla
Humberto
H
Concellón
Carmen
C