title: Selectin polymorphisms and perinatal morbidity in low-birthweight infants.
abstract: BACKGROUND
  Studies have shown an association between altered expression of selectins and premature birth, early sepsis and bronchopulmonary dysplasia.
  
  
  OBJECTIVE
  To investigate the possible link between functional polymorphisms of the E-, P- and L-selectin genes and perinatal morbidity.
  
  
  METHODS
  We compared the genotype distribution of the E-selectin Ser128Arg, P-selectin Thr715Pro and L-selectin Pro213Ser polymorphisms in 125 low-birthweight singleton infants with those of 156 healthy term neonates. We also analysed the association of genotype with risk of sepsis and bronchopulmonary dysplasia.
  
  
  RESULTS
  We found no association between E-selectin or P-selectin polymorphisms and premature birth, nor did we find any association between E-selectin or P-selectin and early postnatal sepsis or bronchopulmonary dysplasia. Carriers of the 213Ser L-selectin allele were found to be more prevalent in low-birthweight infants, particularly in those with bronchopulmonary dysplasia. We found no association between the L-selectin polymorphism and early postnatal sepsis.
  
  
  CONCLUSIONS
  Our results underline the importance of L-selectin in perinatal pathology, but further studies are needed to evaluate the alteration of L-selectin levels in carriers of the 213Ser allele and their possible contribution to premature birth and bronchopulmonary dysplasia.
authors.affiliation: First Department of Paediatrics, Semmelweis University, Budapest, Hungary. derla@gyer1.sote.hu
authors.forename: László
authors.initials: L
authors.lastname: Derzbach
authors.forename: Géza
authors.initials: G
authors.lastname: Bokodi
authors.forename: András
authors.initials: A
authors.lastname: Treszl
authors.forename: Barna
authors.initials: B
authors.lastname: Vásárhelyi
authors.forename: Andras
authors.initials: A
authors.lastname: Nobilis
authors.forename: János
authors.initials: J
authors.lastname: Rigó
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000235:genetics; D019040:E-Selectin / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007230:Infant, Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D019041:L-Selectin / Q000235:genetics; D008297:Male; D009017:Morbidity; D019007:P-Selectin / Q000235:genetics; D011110:Polymorphism, Genetic; D019087:Selectins / Q000235:genetics*; D018805:Sepsis / Q000235:genetics
chemical_list: D019040:E-Selectin; D019007:P-Selectin; D019087:Selectins; D019041:L-Selectin