Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.
Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.
Peltroche-Llacsahuanga
Heidrun
H
Institut für Medizinische Mikrobiologie, RWTH Aachen, Germany.
Goyard
Sophie
S
d'Enfert
Christophe
C
Prill
Stephan K-H
SK
Ernst
Joachim F
JF
D018441:Biofilms / Q000254:growth & development*; D002176:Candida albicans / Q000201:enzymology / Q000254:growth & development* / Q000502:physiology; D003470:Culture Media; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D007527:Isoenzymes; D008364:Mannosyltransferases / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D011137:Polystyrenes
D003470:Culture Media; D005656:Fungal Proteins; D007527:Isoenzymes; D011137:Polystyrenes; D008364:Mannosyltransferases; C082696:protein O-mannosyltransferase