FOXP3 polymorphisms in type 1 diabetes and coeliac disease.
The FOXP3 gene encodes a transcription factor thought to be essential for the development and function of T regulatory cells. Two previous studies have tested common polymorphisms in FOXP3 for association with type 1 diabetes (T1D) with conflicting results. The aim of our study was to see whether there is any evidence of association between the FOXP3 polymorphisms previously reported to be associated with T1D, in a Caucasian population regarding T1D and coeliac disease (CD). We further looked for evidence of interaction between FOXP3 polymorphisms and HLA-DR3 in conferring susceptibility to T1D. Initially, we analysed two microsatellites in the FOXP3 gene in 363 T1D nuclear families. Our results indicated an association between FOXP3 and T1D (global p=0.004) and a possible interaction between FOXP3 and the HLA-DR3-DQ2 susceptibility haplotype. We then genotyped an additional independent set of 826 T1D patients and 1459 controls as well as one CD dataset consisting of 325 families. A similar tendency was revealed in the CD family material (pnc=0.055 for the associated allele). On the other hand, we were unable to reproduce our initial findings in the T1D case-control dataset (global p=0.6). Our results suggest that the tested FOXP3 markers do not have any major impact on susceptibility for these diseases.
Bjørnvold
Marit
M
Institute of Medical Genetics, Faculty Division Ullevål University Hospital, University of Oslo, Oslo, Norway. marit.bjornvold@medisin.uio.no
Amundsen
Silja S
SS
Stene
Lars C
LC
Joner
Geir
G
Dahl-Jørgensen
Knut
K
Njølstad
Pål R
PR
Ek
Johan
J
Ascher
Henry
H
Gudjònsdòttir
Audur H
AH
Lie
Benedicte A
BA
Skinningsrud
Beate
B
Akselsen
Hanne E
HE
Rønningen
Kjersti S
KS
Sollid
Ludvig M
LM
Undlien
Dag E
DE
D000293:Adolescent; D002446:Celiac Disease / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D051858:Forkhead Transcription Factors / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015803:HLA-DR3 Antigen / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015810:Linkage Disequilibrium / Q000235:genetics; D018895:Microsatellite Repeats / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D015803:HLA-DR3 Antigen