title: [Pharmacokinetics-pharmacodynamics of antifungal drugs. Consequences for therapeutic drug monitoring].
abstract: Despite pharmacokinetic-pharmacodynamic relationships were clearly evidenced for antifungal drugs by the use of experimental models, few target plasma concentrations could be determined from studies performed in patients. The main causes explaining this lack of data are reviewed and the possible use in humans of the parameters obtained from animal models is discussed.
authors.affiliation: Université Paris-Descartes, Faculté de Médecine, Paris, France. vincent.jullien@svp.aphp.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Jullien
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D006801:Humans; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D013045:Species Specificity
chemical_list: D000935:Antifungal Agents