Changes in heart rate with refeeding in anorexia nervosa: a pilot study.
OBJECTIVE
To find differences in heart rate before and after refeeding and to identify which parameters of autonomic activity and endocrine function are associated with these differences.


METHODS
Before and after the start of refeeding, body weight, RR interval (RRI), heart rate variability, endocrine function, and energy expenditure were measured in nine female anorexia nervosa patients.


RESULTS
After short-term refeeding, mean daytime heart rate rose from 54.9 to 69.4 bpm (P<.05). The changes in sympathetic activity were correlated negatively with the changes in RRI (r=-.933, P<.001). Urine C-peptide, IGF-1, and fT3 increased significantly, and norepinephrine tended to increase.


CONCLUSIONS
We demonstrated that autonomic nervous activity was relevant to changes in heart rate during refeeding, and it is speculated that the increases in insulin secretion, thyroid function, and IGF-1 were responsible for the mechanisms.
Yoshida
Nahoko Miyasaka
NM
Department of Psychosomatic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. napo@waseda.jp
Yoshiuchi
Kazuhiro
K
Kumano
Hiroaki
H
Sasaki
Tadashi
T
Kuboki
Tomifusa
T
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000628:therapy*; D044466:Asian People; D015992:Body Mass Index; D002149:Energy Intake; D004734:Energy Metabolism; D004837:Epinephrine / Q000652:urine; D005247:Feeding Behavior; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000097:blood; D009638:Norepinephrine / Q000652:urine; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D010865:Pilot Projects; D012720:Severity of Illness Index; D013564:Sympathetic Nervous System / Q000503:physiopathology
D020738:Leptin; D009638:Norepinephrine; D004837:Epinephrine