Activity-dependent modulation of inhibition in Purkinje cells by TrkB ligands.
In the cerebellum in vitro TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis of Purkinje cells and also modulate inhibitory synaptic function. This mini review examines the roles of TrkB receptor activation by BDNF particularly in relation to activity-dependent synaptic plasticity on Purkinje cells and recent studies on the acute modulation of GABAergic synapses by BDNF.
Drake-Baumann
Rosemarie
R
Neurology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA. drakebar@ohsu.edu
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology*; D002531:Cerebellum / Q000166:cytology; D004789:Enzyme Activation / Q000187:drug effects; D008954:Models, Biological; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D011689:Purkinje Cells / Q000187:drug effects* / Q000502:physiology; D020813:Receptor, trkB / Q000378:metabolism*; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D005680:gamma-Aminobutyric Acid; D020813:Receptor, trkB