Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.
Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.
Shubitz
Lisa F
LF
Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85723, USA.
Galgiani
John N
JN
Tian
Zong-Qiang
ZQ
Zhong
Ziyang
Z
Timmermans
Pieter
P
Katz
Leonard
L
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003045:Coccidioides / Q000187:drug effects*; D003047:Coccidioidomycosis / Q000188:drug therapy* / Q000401:mortality; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D016896:Treatment Outcome
D000935:Antifungal Agents; D011714:Pyrans; C014964:ambruticin