title: Experimental model of hemorrhagic stroke: rabbit immunization with HL-60 promyelocytic cell differentiation factor.
abstract: Rabbits immunized with synthetic HLDF differentiation factor developed hemorrhagic stroke with thrombosis of small cerebral vessels and destruction of vascular endotheliocytes. The severity of stroke correlated with serum level of antibodies to differentiation factor. The role of different sites of HLDF molecule in the induction of clinical signs of hemorrhagic stroke was studied.
authors.affiliation: Laboratory of Hormonal Regulation Proteins, M M Shemyakin and Yu A Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences.
authors.forename: M V
authors.initials: MV
authors.lastname: Gapon
authors.forename: S M
authors.initials: SM
authors.lastname: Dranitsyna
authors.forename: N I
authors.initials: NI
authors.lastname: Minkevich
authors.forename: M A
authors.initials: MA
authors.lastname: Gruden'
authors.forename: I I
authors.initials: II
authors.lastname: Babichenko
authors.forename: I A
authors.initials: IA
authors.lastname: Kostanyan
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D018922:HL-60 Cells; D006801:Humans; D007114:Immunization; D008297:Male; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000276:immunology*; D011817:Rabbits; D020521:Stroke / Q000209:etiology* / Q000276:immunology / Q000473:pathology
chemical_list: D009363:Neoplasm Proteins; C091149:cell differentiation factor 8.2-kDa