Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.
Homeostatic control of T cells involves tight regulation of effector T cells to prevent excessive activation that can cause tissue damage and autoimmunity. Little is known, however, about whether antigen-presenting cells (APCs) are also involved in maintaining immune system homeostasis once effector T cells are stimulated. Here we found that immature APCs downregulated effector T cell function by a mechanism involving the C-type lectin MGL expressed by APCs. Glycosylation-dependent interactions of MGL with CD45 on effector T cells negatively regulated T cell receptor-mediated signaling and T cell-dependent cytokine responses, which in turn decreased T cell proliferation and increased T cell death. Thus, regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases.
van Vliet
Sandra J
SJ
Department of Molecular Cell Biology & Immunology, Vrije University Medical Center, Amsterdam, The Netherlands.
Gringhuis
Sonja I
SI
Geijtenbeek
Teunis B H
TB
van Kooyk
Yvette
Y
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016466:CHO Cells; D002478:Cells, Cultured; D002999:Clone Cells; D006224:Cricetinae; D003412:Cricetulus; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D019169:Jurkat Cells; D037181:Lectins, C-Type / Q000378:metabolism* / Q000502:physiology; D017493:Leukocyte Common Antigens / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology
D016207:Cytokines; D037181:Lectins, C-Type; C506225:MGL lectin, human; D017493:Leukocyte Common Antigens