Reductive DNA cleavage induced by UVA photoirradiation of NADH without oxygen.
UVA irradiation of dihydronicotinamide coenzyme (NADH), which plays a key role in a number of biological redox processes, results in effective DNA cleavage without oxygen via photoionization of NADH and the subsequent reaction of hydrated electron with DNA as well as photoinduced electron transfer from NADH to DNA.
Tanaka
Makiko
M
Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency, Suita, Osaka 565-0871, Japan.
Ohkubo
Kei
K
Fukuzumi
Shunichi
S
D004247:DNA / Q000737:chemistry*; D007700:Kinetics; D009243:NAD / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010777:Photochemistry; D014466:Ultraviolet Rays
D009243:NAD; D004247:DNA; D010100:Oxygen