title: Design of a highly sensitive and specific nucleotide sensor based on photon upconverting particles.
abstract: We have designed and developed a novel sensor that reports the presence of specific nucleic acids in solutions, based on photon upconverting particles. The significantly high signal-to-noise ratio of photon upconverting particles leads to high sensitivity of the sensor. The sensor does not suffer from photobleaching. It also displays high specificity and self-calibrating capability. We expect nucleotide sensors of this type to be effective for applications in both DNA/RNA detection and protein-DNA/RNA interaction studies.
authors.affiliation: Department of Chemistry & Laboratory of Nanomaterials Science, New Mexico Tech, Socorro, New Mexico 87801, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Snezna
authors.initials: S
authors.lastname: Rogelj
authors.forename: Khoi
authors.initials: K
authors.lastname: Nguyen
authors.forename: Damon
authors.initials: D
authors.lastname: Wheeler