DEP domains: More than just membrane anchors.
The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.
Chen
Songhai
S
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Hamm
Heidi E
HE
D008956:Models, Chemical; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D020710:RGS Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D015398:Signal Transduction; D013379:Substrate Specificity
D021122:Protein Subunits; D020710:RGS Proteins; D043562:Receptors, G-Protein-Coupled