Identifying the genetic determinants of emotionality in humans; insights from rodents.
The identification of human quantitative trait genes underlying variation in emotionality has proved to be both difficult and expensive. Whilst several QTL have been consistently identified and independently replicated across both phenotypes and populations, little progression has been made towards the identification of underlying genes or even variants. In this review we discuss the potential for using cross-species QTL concordance as a tool for QTL dissection in behaviour genetics, using an affect-related locus mapped to human chromosome 1 as an example.
Willis-Owen
Saffron A G
SA
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK. s.willis-owen@imperial.ac.uk
Flint
Jonathan
J
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D004644:Emotions / Q000502:physiology*; D014644:Genetic Variation; D005824:Genetics, Behavioral / Q000379:methods*; D006801:Humans; D008126:Lod Score; D023421:Models, Animal; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable