title: Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults.
abstract: The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag-time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic difference was minor and presumably of no clinical relevance.
authors.affiliation: Ferring Pharmaceuticals A/S, Kay Fiskers Plads 11 DK-2300 Copenhagen S, Denmark.
authors.forename: Ole
authors.initials: O
authors.lastname: Osterberg
authors.forename: Radojka M
authors.initials: RM
authors.lastname: Savic
authors.forename: Mats O
authors.initials: MO
authors.lastname: Karlsson
authors.forename: Ulrika S H
authors.initials: US
authors.lastname: Simonsson
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Nørgaard
authors.forename: Johan Vande
authors.initials: JV
authors.lastname: Walle
authors.forename: Henrik
authors.initials: H
authors.lastname: Agersø
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000465:Algorithms; D050034:Antidiuretic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001682:Biological Availability; D002648:Child; D018592:Cross-Over Studies; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005612:Freeze Drying; D006801:Humans; D007408:Intestinal Absorption; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008954:Models, Biological; D053206:Nocturnal Enuresis / Q000188:drug therapy* / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D050034:Antidiuretic Agents; D004304:Dosage Forms; D003894:Deamino Arginine Vasopressin