Waking experience affects sleep need in Drosophila.
Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes.
Ganguly-Fitzgerald
Indrani
I
Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92101, USA. transposase@gmail.com
Donlea
Jeff
J
Shaw
Paul J
PJ
D000818:Animals; D001923:Brain Chemistry; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000378:metabolism; D004298:Dopamine / Q000032:analysis / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D005260:Female; D006309:Hearing; D007858:Learning; D008297:Male; D008568:Memory; D023421:Models, Animal; D009154:Mutation; D012726:Sexual Behavior, Animal; D015398:Signal Transduction; D012890:Sleep; D012903:Smell; D012931:Social Environment; D012934:Social Isolation; D014785:Vision, Ocular
D000242:Cyclic AMP; D004298:Dopamine