Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules.
Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.
Webb
Tonya J Roberts
TJ
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, USA.
Litavecz
Roberta A
RA
Khan
Masood A
MA
Du
Wenjun
W
Gervay-Hague
Jacquelyn
J
Renukaradhya
Gourapura J
GJ
Brutkiewicz
Randy R
RR
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology*; D055610:Antigens, CD1d; D015153:Blotting, Western; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology*; D005434:Flow Cytometry; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D009154:Mutation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014616:Vaccinia virus / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*
D018949:Antigens, CD1; D055610:Antigens, CD1d; D004268:DNA-Binding Proteins; C091945:H5R protein, Vaccinia virus; C074058:VB1R protein, Vaccinia virus; D014764:Viral Proteins; D020929:Mitogen-Activated Protein Kinase Kinases