title: Comparison of tuberculin skin test response after three modalities of neonatal BCG vaccination.
abstract: The aim of this study was to determine the tuberculin skin test (TST) response to three different BCG modalities [0.1 ml Tokyo (n=104), 0.05 ml Pasteur-Mérieux (n=137) and 0.1 ml Pasteur-Mérieux (n=100)] in a cohort of healthy newborns 5 months after vaccination at birth in Santiago, Chile. Among the 341 infants, 91.2% had a response to TST, and the mean+/-SD TST reaction size was significantly larger in infants receiving the Tokyo strain than in those receiving the 0.05 ml or 0.1 ml Pasteur-Mérieux strains (4.4+/-2.0, 3.5+/-1.3 and 3.1+/-1.4 mm, respectively; P<0.0001). The mean+/-SD of the BCG scar size was significantly lower in infants vaccinated with the Tokyo strain than in those vaccinated with the 0.1 ml Pasteur-Mérieux strain (3.9+/-1.2 vs. 4.3+/-1.1 mm; P=0.03) and no significant difference was found between infants receiving the Tokyo strain and the 0.05 ml Pasteur-Mérieux strain. However, the differences in TST size induced by diverse BCG vaccination modalities may not reflect the quality of the immunologically induced response in terms of TB protection.
authors.affiliation: Department of Pediatric Respiratory Medicine, Faculty of Medical Sciences, Hospital CRS El Pino, University of Santiago de Chile, Santiago, Chile. jacastro17@hotmail.com
authors.forename: Jose A
authors.initials: JA
authors.lastname: Castro-Rodriguez
authors.forename: Javier
authors.initials: J
authors.lastname: Mallol
authors.forename: Rosa
authors.initials: R
authors.lastname: Andrade
authors.forename: Mónica
authors.initials: M
authors.lastname: Muñoz
authors.forename: Ivanna
authors.initials: I
authors.lastname: Azzini
mesh_terms: D001500:BCG Vaccine / Q000008:administration & dosage*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009163:Mycobacterium bovis / Q000145:classification; D014374:Tuberculin Test; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods
chemical_list: D001500:BCG Vaccine