[Research on resveratrol's mechanism of immunity in anti-aging].
OBJECTIVE
To research resveratrol's mechanism of immunity in anti-aging and explore the new clinical use of resveratrol.


METHODS
The sub acute aging model was made by continuous subcutaneous injection of D galactose to mice inducing reactive oxygen species (ROS). Meanwhile, the resveratrol was given and its effect on anti-aging was observed.


RESULTS
The resveratrol could increase the content of SOD and decrease the content of MDA in serum. There was no change in spleen index, but thymus index increased obvionsly. There was no change in the quantity of CD4+, but the quantity of CD8+ increased and the ratio of CD4+/CD8+ was decreased. The serum IL-6 and IL-8 level were decreased obviously.


CONCLUSIONS
The resveratrol possessed the function to anti-aging and the applications foreground in anyi-aging.
Yao
Yu
Y
Internal Medicine of Oncology, Medical College, Xi'an Jiaotong University, China.
Tian
Tao
T
Nan
Ke-jun
KJ
D000375:Aging / Q000187:drug effects* / Q000276:immunology*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D005260:Female; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D010946:Plants, Medicinal / Q000737:chemistry*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood
D015850:Interleukin-6; D016209:Interleukin-8; D013267:Stilbenes; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000077185:Resveratrol