title: The synaptic vesicle cycle: is kissing overrated?
abstract: In this issue of Neuron, Granseth et al. re-examine the mechanism of endocytosis at hippocampal synapses using a new optical reporter, sypHy. They conclude that only a single slow mode of endocytosis operates at this synapse and that retrieval after physiological stimuli is largely, if not solely, dominated by the clathrin-mediated pathway. These conclusions dispute previous assertions that "kiss-and-run" is a major mechanism of vesicle recycling at hippocampal synapses.
authors.affiliation: Graduate Program in Neuroscience, State University of New York, Stony Brook, New York 11794, USA.
authors.forename: Lisamarie
authors.initials: L
authors.lastname: LoGiudice
authors.forename: Gary
authors.initials: G
authors.lastname: Matthews
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002966:Clathrin / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D008954:Models, Biological; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology*
chemical_list: D002966:Clathrin