Investigating Gata3 as a positional candidate gene for allergic asthma in a murine model.
Gata3 is a positional candidate gene for allergic asthma. We determined allergen-induced GATA-3 mRNA and protein expression in asthma susceptible and resistant mice and generated Gata3 sequence data. Our data indicate that the Gata3 gene in isolation is not a causative agent of asthma susceptibility in our model.
Li
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Genetics Graduate Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Wills-Karp
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Ewart
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D000595:Amino Acid Sequence; D000818:Animals; D001249:Asthma / Q000235:genetics*; D001483:Base Sequence; D004195:Disease Models, Animal; D050990:GATA3 Transcription Factor / Q000032:analysis / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D012130:Respiratory Hypersensitivity / Q000235:genetics
D050990:GATA3 Transcription Factor; C494748:Gata3 protein, mouse; D012333:RNA, Messenger