Pseudosymmetry in azabicyclo[2.1.1]hexanes. A stereoselective construction of the bicyclic core of peduncularine.
Intramolecular photocycloaddition of 41 or its equivalent leads to the formation of photoadduct 25. While retro-Mannich fragmentation of the "b" bond in 25 leads to the formation of 44 (via 43), with the incorrect relative stereochemistry for the synthesis of peduncularine 5, selective fragmentation of the "a" bond in 25 leads to the formation of 42 (via 26) with the correct relative stereochemistry for the synthesis of 5.
Ragains
Justin R
JR
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Winkler
Jeffrey D
JD
D000470:Alkaloids / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D006586:Hexanes / Q000737:chemistry*; D026121:Indole Alkaloids; D007211:Indoles / Q000737:chemistry*
D000470:Alkaloids; D001643:Bridged Bicyclo Compounds; D006586:Hexanes; D026121:Indole Alkaloids; D007211:Indoles; C467792:peduncularine