title: [Drug therapy for irritable bowel syndrome. What works, what doesn't work and for whom?].
abstract: The therapy of patients with irritable bowel syndrome (IBS) is often challenging, especially if a broad spectrum of symptoms is present and trigger factors, such as the influence of diet or stress, are lacking. Current pathogenetic concepts propose central or peripheral alterations that cause disturbed gastrointestinal function (motility, visceral sensitivity) and subsequent symptoms. These alterations are possibly related to psychological (stress, depression, anxiety) and biological (post-infectious residuals, micro-inflammation) influences. Since no universally effective medical treatment is available to treat the causes of the disease, standard medical therapy is symptom directed (especially for pain, constipation and diarrhoea). In addition to well established drugs (like spasmolytics, opioids and laxatives), newly developed compounds including those with other primarily indications (e.g. antidepressants) are available for highly differentiated individualized therapies. New medical approaches which are currently undergoing evaluation, promise further progress in the treatment of IBS.
authors.affiliation: Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Interdisziplinäres Stoffwechsel-Centrum/Endokrinologie und Diabetes mellitus, Charité, Universitätsmedizin Berlin, Campus Virchow-Klinikum, Germany. moennikes@web.de
authors.forename: H
authors.initials: H
authors.lastname: Mönnikes
authors.forename: M
authors.initials: M
authors.lastname: Schmidtmann
authors.forename: I R
authors.initials: IR
authors.lastname: van der Voort
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000188:drug therapy* / Q000209:etiology; D011613:Psychotherapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013001:Somatoform Disorders / Q000188:drug therapy / Q000209:etiology
chemical_list: D000929:Antidepressive Agents, Tricyclic; D005765:Gastrointestinal Agents; D017367:Selective Serotonin Reuptake Inhibitors