title: Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy: a review of the literature and critical reappraisal of the implicated pathomechanism.
abstract: Pylorus-preserving pancreaticoduodenectomy (PPPD) is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head, neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE) comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the efficacy of a recently reported (but not yet tested in large-scale studies) modification, that is, PPPD with antecolic duodenojejunostomy.
authors.affiliation: 2nd Department of Surgery, Agia Olga Hospital, Athens, Greece.
authors.forename: Kosmas I
authors.initials: KI
authors.lastname: Paraskevas
authors.forename: Costas
authors.initials: C
authors.lastname: Avgerinos
authors.forename: Costas
authors.initials: C
authors.lastname: Manes
authors.forename: Dimitris
authors.initials: D
authors.lastname: Lytras
authors.forename: Christos
authors.initials: C
authors.lastname: Dervenis
mesh_terms: D004379:Duodenal Neoplasms / Q000503:physiopathology / Q000601:surgery; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000503:physiopathology / Q000601:surgery; D016577:Pancreaticoduodenectomy / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000503:physiopathology*; D011708:Pylorus / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome