title: Immediate changes in blood-gas tensions during chest physiotherapy with positive expiratory pressure and oscillating positive expiratory pressure in patients with cystic fibrosis.
abstract: OBJECTIVE
  To assess and compare immediate effects of chest physiotherapy with positive expiratory pressure (PEP) versus oscillating PEP on transcutaneously measured blood-gas tensions in patients with cystic fibrosis.
  
  
  METHODS
  Fifteen patients (mean age 12.5 y, range 6.9-21.5 y) participated. The treatments were randomized and performed on 2 separate occasions, 8 weeks apart. Spirometry was conducted before and after each treatment. We transcutaneously measured oxygen tension (P(tO2).
  
  
  RESULTS
  There were no changes in spirometry values. During PEP, different trends in blood-gas tension were seen, and there were no consistent changes. During oscillating PEP, P(tO2) increased and P(tCO2) decreased. During oscillating PEP, P(tCO2) was lower and the intra-individual change in P(tCO2) was more pronounced than during PEP. The results obtained immediately after oscillating PEP showed a higher P(tO2) and a lower P(tCO2) than with PEP.
  
  
  CONCLUSIONS
  PEP and oscillating PEP can both cause transitory effects on blood gases in patients with cystic fibrosis. However, oscillating PEP alters blood-gas tensions more than does PEP, and hyperventilation during oscillating PEP may reduce treatment time.
authors.affiliation: Department of Pediatrics, Sahlgrenska Academy, Göteborg University, Sweden. anna-lena.lagerkvist@vgregion.se
authors.forename: Anna-Lena B
authors.initials: AL
authors.lastname: Lagerkvist
authors.forename: Gunilla M
authors.initials: GM
authors.lastname: Sten
authors.forename: Staffan B
authors.initials: SB
authors.lastname: Redfors
authors.forename: Anders G
authors.initials: AG
authors.lastname: Lindblad
authors.forename: Ola
authors.initials: O
authors.lastname: Hjalmarson
mesh_terms: D000293:Adolescent; D000328:Adult; D001784:Blood Gas Analysis; D002245:Carbon Dioxide; D035641:Chest Wall Oscillation; D002648:Child; D003550:Cystic Fibrosis / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D026741:Physical Therapy Modalities; D011175:Positive-Pressure Respiration / Q000379:methods*; D013909:Thorax
chemical_list: D002245:Carbon Dioxide