title: (-)-Agelasidine A from Agelas clathrodes.
abstract: (-)-Agelasidine A was identified from the methanol extract of the marine sponge Agelas clathrodes for the first time together with zooanemonin, 1-carboxymethylnicotinic acid, hymenidin, mukanadins A and C, monobromodispacamide, agelasidine D, 2-amide-4-bromopyrrole, O-methyltryptophan and an agelasines mixture. The structures were characterized by spectroscopic methods. (-)-Agelasidine A was tested for antibacterial and antifungal activities and shown to act as a bacteriostatic agent as it inhibited the growth of Staphylococcus aureus and partially the growth of other bacteria.
authors.affiliation: Instituto Nacional de Engenharia, Tecnologia e Inovação, Departamento de Tecnologia de Indústrias Químicas, Azinhaga dos Lameiros, 1699-038 Lisboa, Portugal.
authors.forename: Maria Augusta
authors.initials: MA
authors.lastname: Medeiros
authors.forename: Ana
authors.initials: A
authors.lastname: Lourenço
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: Tavares
authors.forename: Maria João Marcelo
authors.initials: MJ
authors.lastname: Curto
authors.forename: Sónia Savluchinske
authors.initials: SS
authors.lastname: Feio
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Roseiro
mesh_terms: D047230:Agelas / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D013210:Staphylococcus / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013450:Sulfones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D006146:Guanidines; D013450:Sulfones; C514584:agelasidine A