[Evidence for the neuroprotective properties of afobazole in experimental model of focal brain ischemia].
The neuroprotective effect of the new selective anxiolytic afobazole was evaluated in rats with ischemic stroke produced by the occlusion of the left middle cerebral artery, with simultaneous ligation of the ipsilateral carotid artery. Afobazole exhibits a protective effect in a dose range from 0.1 to 5.0 mg/kg for the first injection delayed 24 h after operation and double daily injections over the following two days.
Seredenin
S B
SB
Povarova
O V
OV
Medvedev
O S
OS
Val'dman
E A
EA
Seredenina
T S
TS
D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D018696:Neuroprotective Agents