New constituents of sweet Capsicum annuum L. fruits and evaluation of their biological activity.
Four new acyclic diterpene glycosides named capsianosides (1-4), together with 12 known compounds, were isolated from the fresh sweet pepper fruits of Capsicum annuum L., a plant used as a vegetable food, spice, and external medicine. The chemical structures of new natural compounds, as well as their absolute configurations, were established by means of spectroscopic data including infrared, high-resolution mass spectrometry, and one- and two-dimensional nuclear magnetic resonance and by chemical derivatization. The known capsidiol (11) showed bacteriostatic properties in vitro against Helicobacter pylori with a minimum inhibitory concentration (MIC) of 200 microg/mL when compared with the commercial drug metronidazole (MIC, 250 microg/mL). Some purified components were also tested for their antioxidant activities.
De Marino
Simona
S
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131 Napoli, Italy.
Borbone
Nicola
N
Gala
Fulvio
F
Zollo
Franco
F
Fico
Gelsomina
G
Pagiotti
Rita
R
Iorizzi
Maria
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002212:Capsicum / Q000737:chemistry*; D004224:Diterpenes / Q000032:analysis / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D006027:Glycosides / Q000032:analysis / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009844:Oligosaccharides
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D004224:Diterpenes; D006027:Glycosides; D009844:Oligosaccharides; C427209:capsianoside G