title: Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis.
abstract: The biosynthetic pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UKCV4 7AL.
authors.forename: Anna E
authors.initials: AE
authors.lastname: Stanley
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Walton
authors.forename: Malek
authors.initials: M
authors.lastname: Kourdi Zerikly
authors.forename: Christophe
authors.initials: C
authors.lastname: Corre
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Challis
mesh_terms: D053858:Metabolic Networks and Pathways; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000096:biosynthesis; D048372:Streptomyces coelicolor / Q000235:genetics / Q000378:metabolism*
chemical_list: C037661:4-methoxy-2,2'-bipyrrole-5-carboxaldehyde; C010307:prodiginine; D011353:Prodigiosin