Contrast-enhanced magnetic resonance angiography with biodegradable (Gd-DTPA)-cystamine copolymers: comparison with MS-325 in a swine model.
The purpose of this study is to evaluate the use of (Gd-DTPA)-cystamine copolymers (GDCC), a novel biodegradable intravascular polydisulfide-based macromolecular gadolinium(III) contrast agent, for first-pass and steady-state contrast-enhanced magnetic resonance angiography (MRA) in a swine model. A breath-hold background-suppressed 3D MRA of the thorax was performed for first-pass imaging and repeated every 10 min after GDCC injection to monitor the tissue enhancement time course. A navigator-gated 3D MRA of the coronary arteries was performed during steady state following the first-pass imaging. Imaging with intravascular agent MS-325 approximately 1 h after GDCC injection was also included for comparison. Experimental results indicated that GDCC provided significant blood signal-to-noise ratio (SNR) improvement, approximately 1633% for first-pass and 33% for steady-state contrast-enhanced MRA. Compared to MS-325, GDCC provided similar blood enhancement for first-pass and steady-state imaging but with a different tissue enhancement time course. The blood SNR enhancement half-time was 10 +/- 6 min for GDCC and 46 +/- 33 min for MS-325. GDCC provided less enhancement in the liver, bone growth plates, and muscle than MS-325.
Nguyen
Thanh D
TD
Department of Radiology, Weill Medical College of Cornell University, New York, New York 10022, USA.
Spincemaille
Pascal
P
Vaidya
Anagha
A
Prince
Martin R
MR
Lu
Zheng-Rong
ZR
Wang
Yi
Y
D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D003331:Coronary Vessels / Q000033:anatomy & histology / Q000378:metabolism; D003538:Cystamine / Q000737:chemistry*; D005682:Gadolinium / Q000008:administration & dosage / Q000737:chemistry; D019786:Gadolinium DTPA / Q000737:chemistry*; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography / Q000379:methods*; D023421:Models, Animal; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D013552:Swine; D013909:Thorax / Q000033:anatomy & histology / Q000098:blood supply / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D003287:Contrast Media; D009942:Organometallic Compounds; D011108:Polymers; D005682:Gadolinium; D019786:Gadolinium DTPA; D003538:Cystamine; C109932:gadofosveset trisodium