A conserved supergene locus controls colour pattern diversity in Heliconius butterflies.
We studied whether similar developmental genetic mechanisms are involved in both convergent and divergent evolution. Mimetic insects are known for their diversity of patterns as well as their remarkable evolutionary convergence, and they have played an important role in controversies over the respective roles of selection and constraints in adaptive evolution. Here we contrast three butterfly species, all classic examples of Müllerian mimicry. We used a genetic linkage map to show that a locus, Yb, which controls the presence of a yellow band in geographic races of Heliconius melpomene, maps precisely to the same location as the locus Cr, which has very similar phenotypic effects in its co-mimic H. erato. Furthermore, the same genomic location acts as a "supergene", determining multiple sympatric morphs in a third species, H. numata. H. numata is a species with a very different phenotypic appearance, whose many forms mimic different unrelated ithomiine butterflies in the genus Melinaea. Other unlinked colour pattern loci map to a homologous linkage group in the co-mimics H. melpomene and H. erato, but they are not involved in mimetic polymorphism in H. numata. Hence, a single region from the multilocus colour pattern architecture of H. melpomene and H. erato appears to have gained control of the entire wing-pattern variability in H. numata, presumably as a result of selection for mimetic "supergene" polymorphism without intermediates. Although we cannot at this stage confirm the homology of the loci segregating in the three species, our results imply that a conserved yet relatively unconstrained mechanism underlying pattern switching can affect mimicry in radically different ways. We also show that adaptive evolution, both convergent and diversifying, can occur by the repeated involvement of the same genomic regions.
Joron
Mathieu
M
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom. mathieu.joron@ed.ac.uk
Papa
Riccardo
R
Beltrán
Margarita
M
Chamberlain
Nicola
N
Mavárez
Jesús
J
Baxter
Simon
S
Abanto
Moisés
M
Bermingham
Eldredge
E
Humphray
Sean J
SJ
Rogers
Jane
J
Beasley
Helen
H
Barlow
Karen
K
ffrench-Constant
Richard H
RH
Mallet
James
J
McMillan
W Owen
WO
Jiggins
Chris D
CD
D000818:Animals; D044822:Biodiversity; D001695:Biology; D019521:Body Patterning; D002080:Butterflies / Q000502:physiology*; D022202:Chromosomes, Artificial, Bacterial; D017124:Conserved Sequence; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D018895:Microsatellite Repeats; D008954:Models, Biological; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010641:Phenotype