title: [Is there a role for calcium antagonists when beta-adrenergic blockade therapy is contraindicated in post-myocardial infarction?].
abstract: The purpose of this paper is to examine the eventual benefits of treatment with calcium channel blockers in post-myocardial infarction, through an overview of main placebo-controlled trials that have been conducted to test this therapeutic in acute coronary syndromes. It appears obvious that the vast majority of these trials was conducted in the pre-reperfusion era and failed to demonstrate a reduction in mortality. To conclude, the superiority of a therapy with calcium antagonists over a placebo in the management of post-myocardial infarction remains unknown. In contrast, adverse effects associated with the prescription of calcium antagonists are well known.
authors.affiliation: Hôpital cardiologique, Lille, France. pv-ennezat@chru-lille.fr
authors.forename: Pierre-Vladimir
authors.initials: PV
authors.lastname: Ennezat
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Auffray
authors.forename: Julie
authors.initials: J
authors.lastname: Darchis
authors.forename: Maxime
authors.initials: M
authors.lastname: Rousselle
authors.forename: Xavier
authors.initials: X
authors.lastname: Gonin
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Aubert
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Bauchart
authors.forename: Christophe
authors.initials: C
authors.lastname: Bauters
authors.forename: Eric
authors.initials: E
authors.lastname: Van Belle
authors.forename: Philippe
authors.initials: P
authors.lastname: Asseman
mesh_terms: D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D000075202:Contraindications; D004110:Diltiazem / Q000627:therapeutic use; D006801:Humans; D008133:Long QT Syndrome / Q000188:drug therapy; D009203:Myocardial Infarction / Q000188:drug therapy*; D009543:Nifedipine / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine