title: Effects of radiation damping on Z-spectra.
abstract: Radiation damping induced by the strong water magnetization in Z-spectroscopy experiments can be sufficient to perturb significantly the resultant Z-spectrum. With a probe tuned to exact electrical resonance the effects are relatively straightforward, narrowing the central feature of the Z-spectrum. Where, as is commonly the case, the probe is tuned sufficiently well to give optimum signal-to-noise ratio and radiofrequency field strength but is not at exact resonance, radiation damping introduces an unexpected asymmetry into the Z-spectrum. This has the potential to complicate the use of Z-spectrum asymmetry to study chemical exchange, for example in the estimation of pH in vivo.
authors.affiliation: Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
authors.forename: David C
authors.initials: DC
authors.lastname: Williamson
authors.forename: Johanna
authors.initials: J
authors.lastname: Närväinen
authors.forename: Penny L
authors.initials: PL
authors.lastname: Hubbard
authors.forename: Risto A
authors.initials: RA
authors.lastname: Kauppinen
authors.forename: Gareth A
authors.initials: GA
authors.lastname: Morris
mesh_terms: D016477:Artifacts; D003198:Computer Simulation; D004735:Energy Transfer; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008958:Models, Molecular; D011846:Radio Waves; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014867:Water / Q000032:analysis* / Q000737:chemistry*
chemical_list: D014867:Water