title: Influence of alternative mammographic screening scenarios on breast cancer incidence predictions (Finland).
abstract: BACKGROUND
  A population-based early detection programme for breast cancer has been in progress in Finland since 1987. Recently, detailed information about actual screening invitation schemes in 1987-2001 has become available in electronic form, which enables more specific modeling of breast cancer incidence.
  
  
  OBJECTIVE
  To present a methodology for taking into account historical municipality-specific schemes of mass screening when constructing predictions for breast cancer incidence. To provide predictions for numbers of new cancer cases and incidence rates according to alternative future screening policies.
  
  
  METHODS
  Observed municipality-specific screening invitation schemes in Finland during 1987-2001 were linked together with breast cancer data. The incidence rate during the observation period was analyzed using Poisson regression, and this was done separately for localized and non-localized cancers. For modeling, the screening programme was divided into seven different components. Alternative screening scenarios for future mass-screening practices in Finland were created and an appropriate model for incidence prediction was defined.
  
  
  CONCLUSIONS
  Expanding the screening programme would increase the incidence of localized breast cancers; the biggest increase would be obtained by expanding from women aged 50-59 to 50-69. The impacts of changes in the screening practices on predictions for non-localized cancers would be minor.
authors.affiliation: Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Liisankatu 21 B, FIN-00170, Helsinki, Finland. johanna.seppanen@cancer.fi
authors.forename: Johanna
authors.initials: J
authors.lastname: Seppänen
authors.forename: Sirpa
authors.initials: S
authors.lastname: Heinävaara
authors.forename: Timo
authors.initials: T
authors.lastname: Hakulinen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008327:Mammography / Q000639:trends; D008403:Mass Screening / Q000639:trends; D008875:Middle Aged; D010349:Patient Compliance; D011159:Population Surveillance; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors