title: Cell-cell signaling, cyclic di-GMP turnover and regulation of virulence in Xanthomonas campestris.
abstract: The synthesis of virulence factors in the plant pathogen Xanthomonas campestris pathovar campestris is regulated by cell-cell signaling mediated by a diffusible signal factor (DSF), and by the RpfC/RpfG two-component regulatory system. Recent findings have indicated that the perception of the DSF signal requires the RpfC sensor and is linked to the degradation of the intracellular second messenger cyclic di-GMP by the HD-GYP domain regulator RpfG.
authors.affiliation: BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, National University of Ireland, Cork, Ireland.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Fouhy
authors.forename: Jean F
authors.initials: JF
authors.lastname: Lucey
authors.forename: Robert P
authors.initials: RP
authors.lastname: Ryan
authors.forename: J Maxwell
authors.initials: JM
authors.lastname: Dow
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism; D010944:Plants / Q000382:microbiology; D017434:Protein Structure, Tertiary; D053038:Quorum Sensing; D015290:Second Messenger Systems; D015398:Signal Transduction; D037521:Virulence Factors / Q000378:metabolism*; D016959:Xanthomonas campestris / Q000378:metabolism* / Q000472:pathogenicity*
chemical_list: D001426:Bacterial Proteins; C419552:RpfG protein, Xanthomonas campestris; D037521:Virulence Factors; C102500:rpfC protein, Xanthomonas; C062025:bis(3',5')-cyclic diguanylic acid; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D006152:Cyclic GMP