title: Osteonecrosis of the jaw in cancer patients receiving IV bisphosphonates.
abstract: Cases of osteonecrosis of the jaw (ONJ) have been reported with an increasing frequency over the past few years. ONJ is most often identified in patients with cancer who are receiving intravenous bisphosphonate therapy but it has also been diagnosed in patients receiving oral bisphosphonates for nonmalignant conditions. The condition involves exposed bone of the maxilla or mandible. Although it is often associated with a recent dental surgical procedure, spontaneous ONJ can also occur. Patients commonly present with symptoms. Through case reporting and clinical experience, there is a suggestion that the incidence of ONJ in patients with cancer receiving intravenous bisphosphonates ranges between 1% and 10%. Management of ONJ focuses on maximizing oral health, conservative actions with mouth rinses, antibiotics, and avoidance of unnecessary invasive dental procedures. The currently available data on ONJ are reviewed here.
authors.affiliation: Department of Internal Medicine, University of Michigan, Comprehensive Cancer Center, Ann Arbor 48109-0848, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Van Poznak
authors.forename: Cherry
authors.initials: C
authors.lastname: Estilo
mesh_terms: D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D019647:Oral Surgical Procedures; D056948:Orthognathic Surgical Procedures; D010020:Osteonecrosis / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates