Effect of indomethacin on kainic acid-induced memory disorders.
Single administration of kainic acid to Wistar rats impaired quenching of the conditioned response and increased the number of perseverative reactions 2 weeks postinjection. Indomethacin prevented behavioral disturbances induced by kainic acid.
Kulesskaya
N A
NA
Laboratory of Experimental Neurobiology, Institute of Theoretical and Experimental Biophysics, Russian Academy of Medical Sciences, Pushchino. nkylesskaya@rambler.ru
Arkhipov
V I
VI
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007608:Kainic Acid / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000517:prevention & control* / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007608:Kainic Acid; D007213:Indomethacin