title: [Diagnosis of recurrent or residual nasopharyngeal carcinomas in the skull base area with F-18-fluoro-deoxyglucose positron emission tomography].
abstract: OBJECTIVE
  To investigate the diagnostic value of F-18-fluoro-deoxyglucose positron emission tomography (FDG-PET) for the recurrent or residual nasopharyngeal carcinomas in the skull base area.
  
  
  METHODS
  Nine post-irradiation nasopharyngeal carcinoma patients did FDG-PET scanning, CT/MRI imaging and underwent nasopharynx and skull base-biopsy under endoscopy. The results of FDG-PET were evaluated and compared with CT/MRI studies and biopsies.
  
  
  RESULTS
  In 9 cases of post-irradiation nasopharyngeal carcinoma, CT/MRI detected 7 recurrent cases and 2 suspected recurrent cases in occipital bone and clivus. All 9 cases had accumulated FDG in nasopharynx and cranial base. A definite diagnosis was made by biopsy, 3 cases were confirmed recurrence, and others 6 cases were proved mucous chronic inflammation and (or) osteoradionecrosis. The accuracy of FDG-PET was 33.3% (3/9), and the false positive rate was 66.7% (6/9).
  
  
  CONCLUSIONS
  Diagnosis of recurrent or residual nasopharyngeal carcinomas in the skull base area with FDG-PET had high false-positive rate, final diagnosis must depend on histopathologic examination under endoscopy.
authors.affiliation: The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zeng
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Huang
authors.forename: Tai-Xiang
authors.initials: TX
authors.lastname: Lu
authors.forename: Yi-Qing
authors.initials: YQ
authors.lastname: Zheng
authors.forename: Qiu-Jian
authors.initials: QJ
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Sui-Qiao
authors.initials: SQ
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000532:radiotherapy; D049268:Positron-Emission Tomography / Q000379:methods*; D019291:Skull Base / Q000000981:diagnostic imaging*
chemical_list: D019788:Fluorodeoxyglucose F18