title: Myocardial material parameter estimation-a comparative study for simple shear.
abstract: The study of ventricular mechanics-analyzing the distribution of strain and stress in myocardium throughout the cardiac cycle-is crucially dependent on the accuracy of the constitutive law chosen to represent the highly nonlinear and anisotropic properties of passive cardiac muscle. A number of such laws have been proposed and fitted to experimental measurements of stress-strain behavior. Here we examine five of these laws and compare them on the basis of (i) "goodness of fit:" How well they fit a set of six shear deformation tests, (ii) "determinability:" How well determined the objective function is at the optimal parameter fit, and (iii) "variability:" How well determined the material parameters are over the range of experiments. These criteria are utilized to discuss the advantages and disadvantages of the constitutive laws.
authors.affiliation: Bioengineering Institute, University of Auckland, Auckland, New Zealand. h.schmid@auckland.ac.nz
authors.forename: H
authors.initials: H
authors.lastname: Schmid
authors.forename: M P
authors.initials: MP
authors.lastname: Nash
authors.forename: A A
authors.initials: AA
authors.lastname: Young
authors.forename: P J
authors.initials: PJ
authors.lastname: Hunter
mesh_terms: D000818:Animals; D016880:Anisotropy; D003198:Computer Simulation; D004548:Elasticity; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical; D013552:Swine; D016276:Ventricular Function