Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis.
The biosynthetic pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.
Stanley
Anna E
AE
Department of Chemistry, University of Warwick, Coventry, UKCV4 7AL.
Walton
Laura J
LJ
Kourdi Zerikly
Malek
M
Corre
Christophe
C
Challis
Gregory L
GL
D053858:Metabolic Networks and Pathways; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000096:biosynthesis; D048372:Streptomyces coelicolor / Q000235:genetics / Q000378:metabolism*
C037661:4-methoxy-2,2'-bipyrrole-5-carboxaldehyde; C010307:prodiginine; D011353:Prodigiosin