title: [Genomic and extragenomic mechanisms of antiglucocorticoid action of gestagens on thymocytes].
abstract: Effects of a new synthetic progesterone derivative 17a-acetoxy-3b-butanoyloxy-6-methyl-pregna-4,6-dien-20-one (ABMP) and the reference gestagen preparations on the rat thymus were evaluated by the degree of variation of the intracellular levels of calcium and cAMP, 3H-uridine inclusion into RNA, thymocyte viability, and thymus mass. It is shown that gestagens can produce antiglucocorticoid action on thymocytes, this activity being most pronounced in the case of ABMP.
authors.forename: A V
authors.initials: AV
authors.lastname: Semeĭkin
authors.forename: A S
authors.initials: AS
authors.lastname: Dukhanin
authors.forename: R V
authors.initials: RV
authors.lastname: Samoĭlikov
authors.forename: V M
authors.initials: VM
authors.lastname: Rzheznikov
authors.forename: N L
authors.initials: NL
authors.lastname: Shimanovskiĭ
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology*; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D011372:Progestins / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology; D014158:Transcription, Genetic
chemical_list: C498329:17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one; D000970:Antineoplastic Agents; D011372:Progestins; D011965:Receptors, Glucocorticoid; D019326:17-alpha-Hydroxyprogesterone; D003907:Dexamethasone; D000242:Cyclic AMP; D002118:Calcium