title: Prognostic value of myocardial perfusion contrast echocardiography in patients with suggested or known ischemic heart disease.
abstract: OBJECTIVE
  We sought to determine the prognostic value of myocardial contrast echocardiography (MCE) in patients with known or suggested coronary artery disease compared with technetium-99m sestamibi single photon emission computed tomography (SPECT)-myocardial perfusion imaging (MPI).
  
  
  BACKGROUND
  The prognostic value of SPECT-MPI is well established for patients with coronary artery disease. It is less well defined by MCE.
  
  
  METHODS
  In all, 51 consecutive patients with suggested coronary artery disease prospectively underwent MCE and SPECT-MPI at baseline and after dipyridamole infusion. MCE and SPECT-MPI were independently analyzed for myocardial perfusion. Cardiac events during the follow-up period were determined, and event-free survival was calculated for MCE and SPECT-MPI techniques separately.
  
  
  RESULTS
  MCE (log rank P < .005) and SPECT-MPI (log rank P < .05) demonstrated equivalent event-free survival. The negative predictive value for events for both MCE and SPECT-MPI was 100%.
  
  
  CONCLUSIONS
  MCE accurately classifies patients at risk for cardiac events and provides prognostic information comparable with validated SPECT-MPI techniques.
authors.affiliation: Gordon Yu Hoi Chiu Echocardiographic Laboratory, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Doris
authors.initials: D
authors.lastname: Basic
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Siu
authors.forename: Danny M
authors.initials: DM
authors.lastname: Skyba
authors.forename: Cairrine
authors.initials: C
authors.lastname: Sloggett
authors.forename: Michal
authors.initials: M
authors.lastname: Jamorski
authors.forename: R Mark
authors.initials: RM
authors.lastname: Iwanochko
authors.forename: Eric H C
authors.initials: EH
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D018572:Disease-Free Survival; D004452:Echocardiography / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000401:mortality; D009864:Ontario / Q000453:epidemiology; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011379:Prognosis; D019275:Radiopharmaceuticals; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D016037:Single-Blind Method; D015996:Survival Rate; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin