title: Examination of depth-weighted optical signals during cardiac optical mapping: a simulation study.
abstract: Optical mapping has become a powerful tool to explore complex cardiac propagation. Many experiments and studies claimed that the fluorescence obtained from tissue surface is the averaged response of the transmembrane potential upon probing depth rather than only on the surface. With the electrical propagation model and the photon transport model, the effects of depth-weighted optical signals are examined both during a normal excitation wave and a spiral wave. Our results indicate that depth-weighted optical signals may infer cardiac activation dynamics, such as the mode and the direction of the propagation, the spatial distribution of depolarization or repolarization.
authors.affiliation: The key Laboratory of Biomedical Information Engineering of Education Ministry, The School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Xu
authors.forename: Zhenxi
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yinbin
authors.initials: Y
authors.lastname: Jin
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D018780:Body Surface Potential Mapping / Q000379:methods*; D004396:Coloring Agents; D003198:Computer Simulation; D004562:Electrocardiography; D004563:Electrochemistry; D004735:Energy Transfer; D005453:Fluorescence; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008955:Models, Cardiovascular; D017785:Photons
chemical_list: D004396:Coloring Agents