title: Lung cancer in octogenarians: factors affecting morbidity and mortality after pulmonary resection.
abstract: BACKGROUND
  Predictors of morbidity and mortality after pulmonary resection for lung cancer in patients 80 years of age or older are unknown.
  
  
  METHODS
  The medical records of all patients 80 years of age or older who had pulmonary resection for lung cancer from January 1985 through September 2004 were reviewed.
  
  
  RESULTS
  There were 379 patients (248 men, 131 women). Median age was 82 years (range, 80 to 95 years). Pneumonectomy was performed in 25 patients (6.6%), bilobectomy in 7 (1.8%), lobectomy in 240 (63.3%), segmentectomy in 29 (7.7%), and wedge excision in 78 (20.6%). The cancer was squamous cell carcinoma in 143 patients (37.7%), adenocarcinoma in 166 (43.8%), bronchoalveolar cell carcinoma in 47 (12.4%), and other in 23 (6.1%). Complications occurred in 182 patients (48.0%). These included atrial fibrillation in 75 patients, pneumonia in 27, and retained secretions requiring bronchoscopy in 37. Morbidity predictors were male sex (odds ratio [OR], 1.6), hemoptysis (OR, 2.3), and previous stroke (OR, 3.8). Asymptomatic patients had a significantly decreased probability of complications (OR, 0.56). Operative mortality was 6.3% (24 of 379); significant predictors were congestive heart failure (OR, 6.0) and prior myocardial infarction (OR, 4.3). Factors not associated with mortality included previous myocardial revascularization, renal insufficiency (creatinine >1.5 mg/dL), and diabetes mellitus.
  
  
  CONCLUSIONS
  Pulmonary resection for lung cancer in octogenarians is feasible. Congestive heart failure and myocardial infarction, however, correlated with a significant increase in mortality. Prior myocardial revascularization, renal insufficiency, and diabetes were not associated with increased morbidity and mortality.
authors.affiliation: Division of General Thoracic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Dominguez-Ventura
authors.forename: Mark S
authors.initials: MS
authors.lastname: Allen
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Cassivi
authors.forename: Francis C
authors.initials: FC
authors.lastname: Nichols
authors.forename: Claude
authors.initials: C
authors.lastname: Deschamps
authors.forename: Peter C
authors.initials: PC
authors.lastname: Pairolero
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000601:surgery*; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000601:surgery*; D015897:Comorbidity; D005260:Female; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000601:surgery*; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology; D011013:Pneumonectomy / Q000401:mortality / Q000706:statistics & numerical data*; D012307:Risk Factors