title: [Gene therapy with cytokines against cervical cancer].
abstract: Gene therapy is an excellent alternative for treatment of many diseases. Capacity to manipulate the DNA has allowed direct the gene therapy to correct the function of an altered gene, to increase the expression of a gene and to favour the activation of the immune response. This way, it can intend the use of the DNA like medication able to control, to correct or to cure many diseases. Gene therapy against cancer has an enormous potential, and actually the use of the DNA has increased to control diverse cancer in animal models, with very encouraging results that have allowed its applications in experimental protocols in human. This work concentrates a review of the foundations of the gene therapy and its application on cervical cancer, from the point of view of the alterations of the immune system focused on the tumour micro-environment, and the use of the cytokines as immunomodulators.
authors.affiliation: Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: Bermúdez-Morales
authors.forename: Oscar
authors.initials: O
authors.lastname: Peralta-Zaragoza
authors.forename: Vicente
authors.initials: V
authors.lastname: Madrid-Marina
mesh_terms: D016207:Cytokines / Q000502:physiology; D005260:Female; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000628:therapy*
chemical_list: D016207:Cytokines