Dietary patterns and risk of colorectal tumors: a cohort of French women of the National Education System (E3N).
Little is known about the dietary patterns associated with colorectal tumors along the adenoma-carcinoma sequence. Scores for dietary patterns were obtained by factor analysis in women from the French cohort of the European Prospective Investigation into Cancer and Nutrition (1993-2000). Their association with colorectal tumors was investigated in 516 adenoma cases (175 high-risk adenomas) and 4,804 polyp-free women and in 172 colorectal cancer cases and 67,312 cancer-free women. The authors identified four dietary patterns: "healthy" (vegetables, fruit, yogurt, sea products, and olive oil); "Western" (potatoes, pizzas and pies, sandwiches, sweets, cakes, cheese, cereal products, processed meat, eggs, and butter); "drinker" (sandwiches, snacks, processed meat, and alcoholic beverages); and "meat eaters" (meat, poultry, and margarine). For quartile 4 versus quartile 1, an increased risk of adenoma was observed with high scores of the Western pattern (multivariate relative risk (RR) = 1.39, 95% confidence interval: 1.00, 1.94; p(trend) = 0.03) and the drinker pattern (RR = 1.42, 95% confidence interval: 1.10, 1.83; p(trend) = 0.01). The meat-eaters pattern was positively associated with colorectal cancer risk (for quartile 4 vs. quartile 1: RR = 1.58, 95% confidence interval: 0.98, 2.53; p(trend) = 0.02). Dietary patterns that reflect a Western way of life are associated with a higher risk of colorectal tumors.
Kesse
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E
Inserm, ERI20, Equipe E3N, Institut Gustave Roussy, Villejuif Cedex, France.
Clavel-Chapelon
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F
Boutron-Ruault
M C
MC
D000236:Adenoma / Q000453:epidemiology*; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D004032:Diet; D004522:Educational Status; D005163:Factor Analysis, Statistical; D005247:Feeding Behavior; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D015596:Nutrition Assessment; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors