title: Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking.
abstract: Thioredoxin-1 (TRX) is a small redox-active protein with antioxidative effects and redox-regulating functions. Cigarette smoking is a major etiological factor in the pathogenesis of a variety of diseases and recruits systemic immune and inflammatory responses. This report demonstrates that TRX attenuates the systemic inflammatory responses induced by cigarette smoking. The mRNA expressions of tumor necrosis factor alpha (TNF-alpha) and macrophage migration inhibitory factor (MIF) were suppressed in the spleen of TRX overexpressing transgenic mice (TRX-tg) exposed to cigarette smoking, compared with control C57BL/6 mice. In addition, protein carbonylation, a marker of cellular protein oxidation, was enhanced by cigarette smoking in the tissues of heart and liver in control mice more than in TRX-tg mice. These findings suggest that TRX may suppress the systemic inflammatory responses against cigarette smoking.
authors.affiliation: Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Atsuyasu
authors.initials: A
authors.lastname: Sato
authors.forename: Tomijiro
authors.initials: T
authors.lastname: Hara
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
authors.forename: Noriko
authors.initials: N
authors.lastname: Kato
authors.forename: Yuma
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kondo
authors.forename: Michiaki
authors.initials: M
authors.lastname: Mishima
authors.forename: Junji
authors.initials: J
authors.lastname: Yodoi
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D050050:Protein Carbonylation / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D012907:Smoking / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D013879:Thioredoxins / Q000235:genetics* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D011506:Proteins; C491203:TXN protein, human; D014409:Tumor Necrosis Factor-alpha; D013879:Thioredoxins