title: Interaction of tin(II) and arsenic(III) with DNA at the nanostructure film modified electrodes.
abstract: Biosensors based on DNA and DNA-carbon nanotubes film immobilized at the surface of a screen-printed carbon electrode were used for simple in vitro tests of chemical toxicity. The damage to DNA caused by tin(II) and arsenic(III) compounds as components of specific reaction media was evaluated by means of an electrochemical DNA marker, [Co(phen)3](3+), as the portion of original dsDNA which survives an incubation of the biosensor in the cleavage medium. The results were confirmed by the electrically heated electrode and by the measurement of the DNA guanine moiety signal.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, FCHPT STU, Radlinského 9, 81237 Bratislava, Slovakia. adriana.ferancova@stuba.sk
authors.forename: Adriana
authors.initials: A
authors.lastname: Ferancová
authors.forename: Miriam
authors.initials: M
authors.lastname: Adamovski
authors.forename: Peter
authors.initials: P
authors.lastname: Gründler
authors.forename: Jirí
authors.initials: J
authors.lastname: Zima
authors.forename: Jirí
authors.initials: J
authors.lastname: Barek
authors.forename: Jürgen
authors.initials: J
authors.lastname: Mattusch
authors.forename: Rainer
authors.initials: R
authors.lastname: Wennrich
authors.forename: Ján
authors.initials: J
authors.lastname: Labuda
mesh_terms: D001151:Arsenic / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D002412:Cations; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004563:Electrochemistry; D004566:Electrodes; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D010618:Phenanthrolines / Q000737:chemistry; D013696:Temperature; D014001:Tin / Q000737:chemistry*; D018675:Toxicity Tests / Q000295:instrumentation / Q000379:methods*
chemical_list: D002412:Cations; D037742:Nanotubes, Carbon; D009942:Organometallic Compounds; D010618:Phenanthrolines; C414956:triphenanthrolinecobalt(II); D006147:Guanine; D014001:Tin; D004247:DNA; D001151:Arsenic