Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase.
Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 microM [corrected] of IC50 inhibitory activity.
Ding
Yili
Y
Drug Discovery, Valeant Pharmaceuticals Research & Development, 3300 Hyland Avenue Costa Mesa, CA 92626, USA. yi_ding93@yahoo.com
Smith
Kenneth L
KL
Varaprasad
Chamakura V N S
CV
Chang
Eugene
E
Alexander
John
J
Yao
Nanhua
N
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012324:RNA-Dependent RNA Polymerase
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D013449:Sulfonamides; D013844:Thiazoles; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase