Pharmacotherapy of aphasia: myth or reality?
Pharmacotherapy of aphasia had been discussed for the last twenty years with first bromocriptine and amphetamine and then serotoninergic, GABAergic and cholinergic agents. Here, we reviewed the MEDLINE available reports of drug therapy for aphasia. So far, proofs of efficiency were found indubitable for none of the studied molecules. However, some of them showed limited efficiency (piracetam and amphetamine). Moreover, drug therapies for aphasia were less efficient alone than when they were associated with speech therapy.
de Boissezon
Xavier
X
INSERM U455, CHU Purpan, Toulouse 31059, France. xavier.deboissezon@toulouse.inserm.fr
Peran
Patrice
P
de Boysson
Chloé
C
Démonet
Jean-François
JF
D000661:Amphetamine / Q000627:therapeutic use; D001037:Aphasia / Q000188:drug therapy* / Q000209:etiology; D001971:Bromocriptine / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D000077265:Donepezil; D015259:Dopamine Agents / Q000627:therapeutic use; D005473:Fluoxetine / Q000627:therapeutic use; D018755:GABA Agonists / Q000627:therapeutic use; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D017374:Paroxetine / Q000627:therapeutic use; D010830:Physostigmine / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D010889:Piracetam / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D012701:Serotonin / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D020521:Stroke / Q000150:complications; D000077334:Zolpidem
D000661:Amphetamine; D001971:Bromocriptine; D002800:Cholinesterase Inhibitors; D000077265:Donepezil; D015259:Dopamine Agents; D005473:Fluoxetine; D018755:GABA Agonists; D007189:Indans; D018696:Neuroprotective Agents; D017374:Paroxetine; D010830:Physostigmine; D010880:Piperidines; D010889:Piracetam; D011725:Pyridines; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D000077334:Zolpidem