[Surveillance on pathogens of meningococcal meningitis in Beijing, 2005].
OBJECTIVE
To study the pathogens of meningococcal meningitis (MM) in Beijing, 2005.


METHODS
Blood and cerebrospinal fluid specimens from MM patients were detected by polymerase chain reaction. Bacterial strains were analyzed by pulsed-field gel electrophoresis and multilocus sequence typing.


RESULTS
7 of the blood and 5 of cerebrospinal fluid specimens showed positive results. 105 of the Neisseria meningitides strains were isolated from the specimens of patients, close contacts and healthy carriers. Serogroup A and C Neisseria meningitides strains shared the same patterns of pulsed-fieldgel electrophoresis, respectively. The sequence type of serogroup A Neisseria meningitides belonged to ST7 while the sequence type of serogroup C Neisseria meningitides belonged to ST4821.


CONCLUSIONS
Patients suffered from meningococcal meningitis were caused by serogroup A (ST7) and C (ST4821) Neisseria meningitides in Beijing, 2005.
Zhang
Tie-gang
TG
Institute of Immunization and Prevention of Beijing Center for Disease Prevention and Control, Beijing 100013, China.
He
Xiong
X
Chen
Li-juan
LJ
He
Jing-guo
JG
Yang
Jie
J
D002681:China; D004269:DNA, Bacterial / Q000032:analysis; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008585:Meningitis, Meningococcal / Q000382:microbiology*; D038381:Neisseria meningitidis, Serogroup A / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D004269:DNA, Bacterial