Clinical study on effect of Garlicin in stabilizing the carotid artery atherosclerotic plaque in patients with primary hypertension and coronary artery disease.
OBJECTIVE
To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque (CAAP) in patients with primary hypertension and coronary heart disease (PHT-CHD).


METHODS
Seventy-nine patients with PHT-CHD were randomly divided into the treated group (39 patients) treated with garlicin and fosinopril and the control group (40 patients) treated with fosinopril alone. The change of CAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) were measured by ELISA, with the observation proceeding for 52 weeks totally.


RESULTS
By the end of the experiment, the number of complex plaques, Crouse integrals, intima-media thickness, serum ICAM-1 and hs-CRP were significantly lower in the treated group than those in the control group with significant difference (P < 0.05).


CONCLUSIONS
Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.
Cheng
Wen-li
WL
Department of National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing, China. chch20000@yahoo.com.cn
Ke
Yuan-nan
YN
Shi
Zai-xiang
ZX
Wang
Ying
Y
Chen
Li
L
Ju
Gao
G
Fan
Shu-ying
SY
D000368:Aged; D000498:Allyl Compounds / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002097:C-Reactive Protein / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003324:Coronary Artery Disease / Q000150:complications / Q000188:drug therapy*; D004220:Disulfides / Q000008:administration & dosage*; D005260:Female; D017328:Fosinopril / Q000008:administration & dosage; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
D000498:Allyl Compounds; D000959:Antihypertensive Agents; D004220:Disulfides; D018799:Intercellular Adhesion Molecule-1; C028009:diallyl disulfide; D002097:C-Reactive Protein; D017328:Fosinopril