[Anti-proliferation effect of serum containning WEI KANG NING on gastric cancer MGC-803 cells and its mechanism].
OBJECTIVE
To investigate the anti-proliferation effect of WEI KANG NING on gastric cancer.


METHODS
MGC-803 cells were cultured in different concentrations of serum containning WEI KANG NING. The inhibitory ratio of the cells was measured by MTT assay. Apoptosis was observed by Hoechst 33258 fluorescence staining.


RESULTS
Each concentration of serum containning WEI KANG NING could inhibit cells proliferation. Among them, both high and medium concentration could inhibit longer. Moreover, high concentration could induce cells apoptosis.


CONCLUSIONS
WEI KANG NING serum has anti-proliferation effect on MGC-803 cells and the effect may be related to cell apoptosis induced by WEI KANG NING.
Feng
Chun-xia
CX
The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Li
Qing-ming
QM
Liang
Wei-wen
WW
Wei
Jing
J
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013274:Stomach Neoplasms / Q000473:pathology*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal