Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolated from Mongolian patients with chronic HBV infection.
Although there is a report of a high rate of hepatitis B virus (HBV) infection in Mongolia, the entire nucleotide sequence of HBV circulating among Mongolian patients has not been reported. To obtain the complete nucleotide sequence of the Mongolian HBV, viral DNA was extracted from sera of patients with HBV infection. Six Mongolian HBV strains were amplified by PCR. Complete genomic sequences were determined for two Mongolian HBV isolates, MBT181 and MMU36. The entire genome of Mongolian HBV isolates was 3,182 bp long and genetic distance between Mongolian HBV isolates was 3.2%. Precore stop codon resulting from a guanine to adenine mutation at nucleotide 1,896 was detected in MBT181 strain. Based on phylogenetic analysis, the six Mongolian isolates were classified as genotype D.
Odgerel
Zagaa
Z
Department of Microbiology, College of Medicine, Korea University, Seoul, 136-705, Korea.
Choi
In Keun
IK
Byun
Kwan Soo
KS
Pak
Chin Yong
CY
Bennett
Shannon
S
Gu
Se-Hun
SH
Park
Kwangsook
K
Kee
Sun Ho
SH
Song
Ki-Joon
KJ
Song
Jin-Won
JW
D019943:Amino Acid Substitution; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D016679:Genome, Viral; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000821:virology*; D006801:Humans; D008986:Mongolia; D010802:Phylogeny; D014764:Viral Proteins / Q000235:genetics
D004279:DNA, Viral; D014764:Viral Proteins