title: Pathologic and physiologic function in the subcortical band of double cortex.
abstract: Double cortex is a neuronal migration disorder, associated with impaired cognitive function and seizures, and characterized by a subcortical band of neurons. Using functional MRI, we assessed the involvement of the subcortical band in language function and with interictal discharges. In both girls assessed, language-associated activation was in typical cortical areas, as well as in parts of the subcortical band. Interictal discharges were associated with deactivation in the subcortical band. This suggests involvement of the subcortical neurons in physiologic and pathologic functions.
authors.affiliation: Brain Research Institute, Neurosciences Building, Austin Health, Heidelberg Heights, Victoria 3081, Australia.
authors.forename: R S
authors.initials: RS
authors.lastname: Briellmann
authors.forename: T
authors.initials: T
authors.lastname: Little
authors.forename: A S
authors.initials: AS
authors.lastname: Harvey
authors.forename: D F
authors.initials: DF
authors.lastname: Abbott
authors.forename: R
authors.initials: R
authors.lastname: Jacobs
authors.forename: A B
authors.initials: AB
authors.lastname: Waites
authors.forename: G D
authors.initials: GD
authors.lastname: Jackson
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods; D010100:Oxygen / Q000097:blood; D014705:Verbal Behavior / Q000502:physiology
chemical_list: D010100:Oxygen