Is there an optimal ribosome concentration for maximal protein production?
A core model is presented for protein production in Escherichia coli to address the question whether there is an optimal ribosomal concentration for non-ribosome protein production. Analysing the steady-state solution of the model over a range of mRNA concentrations, indicates that such an optimum ribosomal content exists, and that the optimum shifts to higher ribosomal contents at higher specific growth rates.
Snoep
J L
JL
Triple J Group for Molecular Cell Physiology, Department of Biochemistry, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa. jls@sun.ac.za
Westerhoff
H V
HV
Rohwer
J M
JM
Hofmeyr
J H S
JH
D003198:Computer Simulation; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D012270:Ribosomes / Q000502:physiology*
D012333:RNA, Messenger