title: Absence of an interaction between iron and mycophenolate mofetil absorption.
abstract: OBJECTIVE
  To determine whether concomitant iron affects the absorption of mycophenolate mofetil.
  
  
  METHODS
  An open-label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co-administered with iron (treatment B).
  
  
  RESULTS
  The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 +/- 10.5 and 44.7 +/- 12.4 microg ml(-1) h, respectively. anova modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19).
  
  
  CONCLUSIONS
  There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.
authors.affiliation: Clinical Pharmacology Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland. patricia.sanwald_ducray@roche.com
authors.forename: Patricia Sanwald
authors.initials: PS
authors.lastname: Ducray
authors.forename: Ludger
authors.initials: L
authors.lastname: Banken
authors.forename: Marianne
authors.initials: M
authors.lastname: Gerber
authors.forename: Bruno
authors.initials: B
authors.lastname: Boutouyrie
authors.forename: Hagen
authors.initials: H
authors.lastname: Zandt
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004347:Drug Interactions; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007501:Iron; D008297:Male; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D005296:Ferrous Compounds; D007166:Immunosuppressive Agents; D007501:Iron; D009173:Mycophenolic Acid