[The G/C polymorphism of RAD51 gene in breast cancer].
The development of breast cancer is associated with an accumulation of specific genetic alterations. The aim. In this study the distribution of G/G, G/C and C/C genotype and frequencies of the G and C allele of RAD51 G/C polymorphism in women with breast cancer was examined.


METHODS
85 breast cancer samples were included in this study. They were categorised according to Scarf-Bloom-Richardson criteria in women with breast cancer. Blood samples age matched healthy individuals (n = 91) served as control.


RESULTS
The distribution of the genotypes of the G/C polymorphism RAD51 in both control and patients did not differ significantly (p>0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences in the genotype distributions and allele frequencies between node-positive and node-negative patients.


CONCLUSIONS
Our study implies that it is possible that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer but further researches, conducted on larger population, are needed to clarify this point.
Romanowicz-Makowska
Hanna
H
Instytut Centrum Zdrowia Matki Polki w Lodzi, Pracownia Biologii Molekularnej, Zakład Patomorfologii Klinicznej.
Smolarz
Beata
B
Kulig
Andrzej
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002277:Carcinoma / Q000235:genetics* / Q000556:secondary*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051135:Rad51 Recombinase / Q000235:genetics* / Q000378:metabolism; D012016:Reference Values
D014408:Biomarkers, Tumor; C495153:RAD51 protein, human; D051135:Rad51 Recombinase