Bioengineered nerve regeneration and muscle reinnervation.
The peripheral nervous system has the intrinsic capacity to regenerate but the reinnervation of muscles is often suboptimal and results in limited recovery of function. Injuries to nerves that innervate complex organs such as the larynx are particularly difficult to treat. The many functions of the larynx have evolved through the intricate neural regulation of highly specialized laryngeal muscles. In this review, we examine the responses of nerves and muscles to injury, focusing on changes in the expression of neurotrophic factors, and highlight differences between the skeletal limb and laryngeal muscle systems. We also describe how artificial nerve conduits have become a useful tool for delivery of neurotrophic factors as therapeutic agents to promote peripheral nerve repair and might eventually be useful in the treatment of laryngeal nerve injury.
Kingham
Paul J
PJ
Blond McIndoe Research Laboratories, University of Manchester, Manchester, UK. paul.j.kingham@manchester.ac.uk
Terenghi
Giorgio
G
D001369:Axons / Q000502:physiology; D001672:Biocompatible Materials; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D007830:Larynx / Q000502:physiology; D009132:Muscles / Q000294:innervation*; D009414:Nerve Growth Factors / Q000502:physiology; D009416:Nerve Regeneration; D061226:Recurrent Laryngeal Nerve Injuries; D023822:Tissue Engineering / Q000379:methods
D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins; D009414:Nerve Growth Factors