HIV type 1 zidovudine (ZDV) resistance in blood and uterine cervical secretions of pregnant women.
To determine if HIV-1 resistance testing of the blood predicts mutants in the genital secretions of ZDV-treated pregnant women, ZDV resistance mutations were assessed by an oligonucleotide ligation assay. ZDV resistance was detected in viral sequences from blood (16/48; 33%) and cervical secretions (6/24; 25%) collected during 57 pregnancies. The genotype of 11/69 (16%) resistance codons was discordant between blood and cervical virus of pregnant women near term. However, in only 1 (1.8%) of 57 pregnancies evaluated was resistant virus limited to the cervical secretions. ZDV-resistant virus is rarely limited to the female genital tract.
Frenkel
Lisa M
LM
University of Washington, Seattle, Washington 98109., Children's Hospital and Medical Center of Seattle, Seattle, Washington 98105, USA. lfrenkel@u.washington.edu
McKernan
Jennifer
J
Dinh
Phil V
PV
Goldman
Deborah
D
Hitti
Jane
J
Watts
D Heather
DH
Cooper
Ellen R
ER
Dragavon
Joan
J
Coombs
Robert W
RW
D019380:Anti-HIV Agents / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002582:Cervix Mucus / Q000821:virology; D024882:Drug Resistance, Viral / Q000235:genetics* / Q000502:physiology; D005260:Female; D005836:Genitalia, Female / Q000821:virology; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D010949:Plasma / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012194:RNA-Directed DNA Polymerase / Q000235:genetics; D015215:Zidovudine / Q000494:pharmacology*
D019380:Anti-HIV Agents; D015415:Biomarkers; D015215:Zidovudine; D012194:RNA-Directed DNA Polymerase