title: Diagnosis of acute foetal distress does not preclude banking of umbilical cord blood units.
abstract: Clinical diagnosis of acute foetal distress (AFD) is based on several parameters such as abnormal foetal heart rate (FHR) pattern and/or meconium liquid staining (MLS). Standards for cord blood (CB) banking indicate that AFD should be considered as exclusion criteria for CB collection, but precise guidelines on how to proceed with CB collection in the presence of AFD signs during labour are not available. We evaluated whether the presence of FHR abnormality and/or MLS during labour 1) reduced the CB collection activity; 2) were associated with the infant's acidaemia or asphyxia and 3) deteriorated the biological characteristics of CB units. Thirty-three units of CB were evaluated for biological parameters, gas values and newborn's Apgar score. The results were compared with a control group of 33 consecutive units previously banked. No differences were observed between the two groups and all but one newborn showed normal Apgar score and absence of metabolic acidaemia. The results showed that 1) AFD reduced the CB collection activity by 10% each year; 2) the majority of CB units collected in the presence of abnormal FHR and/or meconium have biological characteristics eligible for banking; 3) FHR alterations or meconium in the presence of normal gas analysis do not represent certain diagnosis of AFD.
authors.affiliation: Department of Hematology, University Tor Vergata, St Eugenio Hospital, Rome, Italy. picardi@med.uniroma2.it
authors.forename: A
authors.initials: A
authors.lastname: Picardi
authors.forename: A
authors.initials: A
authors.lastname: Tamburini
authors.forename: T
authors.initials: T
authors.lastname: Caravita
authors.forename: C
authors.initials: C
authors.lastname: De Angelis
authors.forename: G
authors.initials: G
authors.lastname: Ballatore
authors.forename: A
authors.initials: A
authors.lastname: Spagnoli
authors.forename: C
authors.initials: C
authors.lastname: Malerba
authors.forename: A
authors.initials: A
authors.lastname: Calugi
authors.forename: P
authors.initials: P
authors.lastname: de Fabritiis
authors.forename: S
authors.initials: S
authors.lastname: Amadori
mesh_terms: D001034:Apgar Score; D001238:Asphyxia Neonatorum; D001782:Blood Donors; D001793:Blood Preservation / Q000009:adverse effects / Q000379:methods; D001800:Blood Specimen Collection / Q000009:adverse effects / Q000379:methods; D000075202:Contraindications; D015925:Cryopreservation / Q000379:methods; D046148:Donor Selection / Q000379:methods* / Q000592:standards; D005260:Female; D005312:Fetal Blood; D005316:Fetal Distress / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium; D011247:Pregnancy; D011256:Pregnancy Outcome