Asthma exacerbations . 3: Pathogenesis.
Asthma exacerbations are an exaggerated lower airway response to an environmental exposure. Respiratory virus infection is the most common environmental exposure to cause a severe asthma exacerbation. Airway inflammation is a key part of the lower airway response in asthma exacerbation, and occurs together with airflow obstruction and increased airway responsiveness. The patterns of airway inflammation differ according to the trigger factor responsible for the exacerbation. The reasons for the exaggerated response of asthmatic airways are not completely understood, but recent studies have identified a deficient epithelial type 1 interferon response as an important susceptibility mechanism for viral infection.
Wark
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PA
Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, NSW 2310 Australia.
Gibson
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PG
D000208:Acute Disease; D000485:Allergens / Q000009:adverse effects; D001249:Asthma / Q000209:etiology / Q000473:pathology*; D001988:Bronchiolitis / Q000473:pathology*; D004198:Disease Susceptibility; D004785:Environmental Pollutants / Q000633:toxicity; D006801:Humans; D009093:Mucus / Q000382:microbiology; D016273:Occupational Exposure / Q000009:adverse effects; D012141:Respiratory Tract Infections / Q000473:pathology; D012907:Smoking / Q000009:adverse effects; D014777:Virus Diseases / Q000473:pathology
D000485:Allergens; D004785:Environmental Pollutants