Enantio- and diastereoselective hydrogenation via dynamic kinetic resolution by a cationic iridium complex in the synthesis of beta-hydroxy-alpha-amino acid esters.
Anti-selective asymmetric hydrogenation of alpha-amino-beta-keto esters via dynamic kinetic resolution under low hydrogen pressure has been achieved by an easily-handled cationic iridium complex with tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (BARF) as a counterion.
Makino
Kazuishi
K
Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Iwasaki
Masamichi
M
Hamada
Yasumasa
Y
D000596:Amino Acids / Q000737:chemistry*; D002412:Cations; D004952:Esters; D006859:Hydrogen / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D007700:Kinetics; D013237:Stereoisomerism
D000596:Amino Acids; D002412:Cations; D004952:Esters; D007495:Iridium; D006859:Hydrogen