title: A novel dentifrice technology for advanced oral health protection: A review of technical and clinical data.
abstract: Throughout the world, dentifrices have played a key role in the practice of good oral hygiene and promotion of better oral health. In addition to providing general dental cleaning, toothpastes also have served as an excellent vehicle for the introduction of new agents that deliver therapeutic and cosmetic benefits. Key examples of using dentifrices to provide added benefits include the introduction in 1955 of the first fluoridated toothpaste clinically proven to fight caries (Crest Cavity Protection) and the launch of the first tartar-control dentifrice (Crest Tartar Control) in the mid-1980s. To continue expanding the health and esthetic benefits offered by a single dentifrice, a multitude of agents have been investigated over the past 3 decades. The focus of these investigations has been in the multibenefit segment, the most widely used among US consumers.
authors.affiliation: Health Care Research Center, The Procter & Gamble Company, Mason, Ohio, USA.
authors.forename: Arif
authors.initials: A
authors.lastname: Baig
authors.forename: Tao
authors.initials: T
authors.lastname: He
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002327:Cariostatic Agents / Q000737:chemistry / Q000494:pharmacology; D003728:Dental Calculus / Q000188:drug therapy; D003731:Dental Caries / Q000188:drug therapy; D003773:Dental Plaque / Q000188:drug therapy; D003807:Dentin Sensitivity / Q000188:drug therapy; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D010710:Phosphates / Q000737:chemistry / Q000494:pharmacology*; D014002:Tin Fluorides / Q000737:chemistry / Q000494:pharmacology*; D014075:Tooth Discoloration / Q000188:drug therapy; D014076:Tooth Diseases / Q000188:drug therapy*; D014100:Toothpastes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002327:Cariostatic Agents; C510825:Crest Pro-Health Dentifrice; D010710:Phosphates; D014002:Tin Fluorides; D014100:Toothpastes; C009285:sodium polymetaphosphate