Novel nucleotide triphosphates as potent P2Y2 agonists.
The synthesis and P2Y2 activities of a novel series of nucleoside triphosphates are described. Many of these compounds were potent agonists of the P2Y2 receptor.
Brookings
Daniel
D
UCB-Group, Granta Park, Abington, Cambridge CB1 6GS, UK.
Davenport
Richard J
RJ
Davis
Jeremy
J
Galvin
Frances C A
FC
Lloyd
Steve
S
Mack
Stephen R
SR
Owens
Ray
R
Sabin
Verity
V
Wynn
Joanne
J
D045744:Cell Line, Tumor; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009711:Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology*; D058910:Purinergic P2 Receptor Agonists; D058473:Receptors, Purinergic P2Y2; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013329:Structure-Activity Relationship; D014544:Uridine Triphosphate / Q000494:pharmacology
D018076:DNA, Complementary; D007202:Indicators and Reagents; D009711:Nucleotides; C546385:P2RY2 protein, human; D058910:Purinergic P2 Receptor Agonists; D058473:Receptors, Purinergic P2Y2; D014544:Uridine Triphosphate