title: Localized reactive angioendotheliomatosis.
abstract: We present a unique case of a woman with multiple painful dermal lesions localized to the left upper quadrant of the body. Histological investigation revealed microvascular thrombosis with capillary-wall proliferation. Further investigation revealed a very high anticardiolipin IgG titre and a left subclavian stenosis, presumably providing the reduced blood flow and relative hypoxia to allow microthromboses to occur in the presence of a thrombophilic tendency. Similar clinical and histological features have been reported in patients with the antiphospholipid syndrome and cases of reactive angioendotheliomatosis (RAE). This case represents a unique variant of RAE.
authors.affiliation: Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK. kirkesandra@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Kirke
authors.forename: B
authors.initials: B
authors.lastname: Angus
authors.forename: P J L
authors.initials: PJ
authors.lastname: Kesteven
authors.forename: E
authors.initials: E
authors.lastname: Calonje
authors.forename: N
authors.initials: N
authors.lastname: Simpson
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000097:blood*; D001024:Aortic Valve Stenosis / Q000150:complications*; D005260:Female; D006390:Hemangioendothelioma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009383:Neoplasms, Vascular Tissue / Q000209:etiology / Q000473:pathology*; D020151:Protein C Deficiency / Q000150:complications; D013927:Thrombosis / Q000188:drug therapy
chemical_list: D017153:Antibodies, Anticardiolipin