title: [Study on the epidemiology and etiologic agent of Dengue fever outbreaks in Fuzhou in 2004].
abstract: OBJECTIVE
  To study the epidemiology and etiologic characteristics of a Dengue fever outbreak in Fuzhou from the beginning of September to the end of October in 2004 in order to understand the source of infection.
  
  
  METHODS
  Data on descriptive epidemiology was collected to study the characteristics and related factors to the epidemic. Dengue virus was isolated through the use of C6/36 cell line while viral serotypes were identified by indirect immunofluorecent assay with type-specific monoclonal antibody. The sources of infection were traced by nucleotide sequencing.
  
  
  RESULTS
  During the epidemic, 93 cases occured consistently with the region entomoplily growth and decay. The viruses of 6 strains isolated from 10 patients' blood specimens were identified as dengue virus type 1. Phylogenetic evidence suggested that the viral isolate had high genetic relation with the isolates from Kampuchea (DENV-1/KHM/2001; GenBank Accession No. L0904278).
  
  
  CONCLUSIONS
  The epidemic was caused by introduction of patients migrating into Fuzhou.
authors.affiliation: Fujian Centers for Disease Control and Prevention, Fuzhou 350001, China.
authors.forename: Yan-sheng
authors.initials: YS
authors.lastname: Yan
authors.forename: Ront-tao
authors.initials: RT
authors.lastname: Hong
authors.forename: Xiao-na
authors.initials: XN
authors.lastname: Shen
authors.forename: Yu-wei
authors.initials: YW
authors.lastname: Weng
authors.forename: Shao-jian
authors.initials: SJ
authors.lastname: Cai
authors.forename: Bao-hai
authors.initials: BH
authors.lastname: Xu
authors.forename: Shi-qing
authors.initials: SQ
authors.lastname: Li
authors.forename: Jia-xin
authors.initials: JX
authors.lastname: He
authors.forename: Long-shan
authors.initials: LS
authors.lastname: Xu
authors.forename: Yun-qing
authors.initials: YQ
authors.lastname: Lin
authors.forename: Neng-xiong
authors.initials: NX
authors.lastname: Zheng
authors.forename: Mao
authors.initials: M
authors.lastname: Lin
authors.forename: Shu-hua
authors.initials: SH
authors.lastname: Lin
mesh_terms: D002681:China / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology*; D003716:Dengue Virus / Q000235:genetics* / Q000302:isolation & purification; D004196:Disease Outbreaks; D004641:Emigration and Immigration; D014644:Genetic Variation; D006801:Humans; D010802:Phylogeny