title: Reoperation of the aortic valve in octogenarians.
abstract: BACKGROUND
  Because of increasing life expectancy of patients with heart valve replacement and a limited durability of heart valve bioprostheses, cardiac reoperation becomes necessary in a significant percentage of patients. Reliable data on mortality and risk factors in octogenarians after replacement of aortic valve prostheses are scanty, however.
  
  
  METHODS
  We retrospectively analyzed 71 patients aged 80 years and older who underwent cardiac reoperation of the aortic valve (69 bioprostheses, 2 mechanical prostheses) between 1991 and 2004 at our heart center. Survival rate of the study cohort was compared with a control group of octogenarians matched for age, sex, and year of aortic valve replacement. To assess predictors of 30-day survival and 3-year survival, we performed univariate and multivariate analyses.
  
  
  RESULTS
  Survival rates at 30 days, 1 year, 3 years and 5 years were 83.6%, 76.1%, 70.8%, and 51.3%, respectively. Results did not differ significantly between the study cohort and the controls. Patients with reoperation had an estimated median survival of 5.6 years. Postoperative complications such as low cardiac output syndrome and intestinal failure were the only independent predictors of 30-day survival (p = 0.020 and p = 0.015, respectively). Low cardiac output, intestinal failure, and diabetes mellitus were independent predictors of 3-year survival (p = 0.001 to 0.033).
  
  
  CONCLUSIONS
  Our data demonstrate that it is possible to achieve an acceptable outcome in octogenarians who have reoperation of the aortic valve prosthesis. Early and mid-term survival is predominantly influenced by unexpected postoperative complications and not by preoperative risk factors, with the exception of diabetes mellitus.
authors.affiliation: Department of Cardiothoracic Surgery, Heart and Diabetes Center NRW, North-Rhine Westfalia, Ruhr University Bochum, Bad Oeynhausen, Germany. teitz@hdz-nrw.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Eitz
authors.forename: Dirk
authors.initials: D
authors.lastname: Fritzsche
authors.forename: Georg
authors.initials: G
authors.lastname: Kleikamp
authors.forename: Armin
authors.initials: A
authors.lastname: Zittermann
authors.forename: Dieter
authors.initials: D
authors.lastname: Horstkotte
authors.forename: Reiner
authors.initials: R
authors.lastname: Körfer
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality* / Q000706:statistics & numerical data; D006801:Humans; D008017:Life Expectancy; D011183:Postoperative Complications / Q000453:epidemiology*; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome