title: Microhardness of starch based biomaterials in simulated physiological conditions.
abstract: In this work the variation of the surface mechanical properties of starch-based biomaterials with immersion time was followed using microhardness measurements. Two blends with very distinct water uptake capabilities, starch/cellulose acetate (SCA) and starch/poly(epsilon-caprolactone) (SPCL), were immersed in a phosphate buffer solution (PBS) at 37.5 degrees C for various times. The microhardness of the blends decreased significantly ( approximately 50% for SPCL and approximately 94% for SCA), within a time period of 30 days of immersion, reflecting the different hydrophilic character of the synthetic components of the blends. The dependence of microhardness on the applied loading time and load was also analysed and showed a power law dependency for SCA. Water uptake and weight loss measurements were performed for the same immersion times used in the microhardness experiments. The different swelling/degradation behaviour presented by the blends was related to the respective variation in microhardness. Moreover, complementary characterization of the mechanical properties of SCA and SPCL was accomplished by dynamic mechanical analysis (DMA) and creep measurements. Microhardness measurements proved to be a useful technique for characterizing the mechanical behaviour near the surface of polymeric biomaterials, including in simulated physiological conditions.
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
authors.forename: N M
authors.initials: NM
authors.lastname: Alves
authors.forename: C
authors.initials: C
authors.lastname: Saiz-Arroyo
authors.forename: M A
authors.initials: MA
authors.lastname: Rodriguez-Perez
authors.forename: R L
authors.initials: RL
authors.lastname: Reis
authors.forename: J F
authors.initials: JF
authors.lastname: Mano
mesh_terms: D001672:Biocompatible Materials; D013213:Starch
chemical_list: D001672:Biocompatible Materials; D013213:Starch