title: The role of bovine preserved peritoneum in rats ventral hernia: a histological evaluation.
abstract: OBJECTIVE
  To assess the role of preserved bovine parietal peritoneum as a material for hernia repair in a rat ventral hernia model.
  
  
  METHODS
  An abdominal wall defect (15mm x 25mm) was created in Wistar male rats (n=40). Control animals (n=20) had the polypropylene (PP) mesh sutured into the defect, whereas bovine preserved peritoneum (BPP) was used in experimental group (n=20). After 7 and 28 days, the abdominal wall was taken off and histological studies of the amount of collagen by Sirius Red stain and morphometric evaluation consisted in quantitative analysis of the collagen by using specific software (Imagelab). The Mann-Whitney, Kruskal-Wallis and ANOVA tests were applied for statistical analysis (pd"0.05).
  
  
  RESULTS
  Histological examination revealed no difference between the BPP and PP groups (p = 0.55 NS).
  
  
  CONCLUSIONS
  BPP is suitable for the closure of ventral hernias in rat model as shown by its morphological properties.
authors.affiliation: Postgraduate Program in Surgery and Experimentation, Federal University of São Paulo (UNIFESP), Rua Carlos Botelho 246, 17515-240 Marília (SP), Brazil. edbastos@unimedmarilia.com.br
authors.forename: Eduardo Lemos de Souza
authors.initials: EL
authors.lastname: Bastos
authors.forename: Djalma José
authors.initials: DJ
authors.lastname: Fagundes
authors.forename: Murched Omar
authors.initials: MO
authors.lastname: Taha
authors.forename: Neil Ferreira
authors.initials: NF
authors.lastname: Novo
authors.forename: Yara
authors.initials: Y
authors.lastname: Juliano
authors.forename: Manuel de Jesus
authors.initials: Mde J
authors.lastname: Simões
authors.forename: Rubens Augusto Brazil
authors.initials: RA
authors.lastname: Silvado
mesh_terms: D034861:Abdominal Wall / Q000473:pathology* / Q000601:surgery; D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials / Q000592:standards*; D001835:Body Weight; D002417:Cattle; D003094:Collagen / Q000032:analysis; D004195:Disease Models, Animal; D006084:Graft Rejection; D006555:Hernia, Ventral / Q000473:pathology / Q000601:surgery*; D008297:Male; D008422:Materials Testing; D010537:Peritoneum / Q000473:pathology* / Q000637:transplantation; D011126:Polypropylenes; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013526:Surgical Mesh
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes; D003094:Collagen