New dihydrodibenzoxepins from Bulbophyllum kwangtungense.
Three new dihydrodibenzoxepins 7,8-dihydro-5-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (1), 7,8-dihydro-4-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (2), and 7,8-dihydro-3-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (3), were isolated from Bulbophyllum kwangtungense Schlecht, along with three known compounds, cumulatin (4), densiflorol A (5) and plicatol B (6). Their structures were established by a combination of 1D and 2D NMR spectroscopic techniques. All new compounds (1-3) and the known compound densiflorol A (5) exhibited anti-tumor activities against HeLa and K562 human tumor cell lines.
Wu
Bin
B
Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. China.
He
Shan
S
Pan
Yuan-jiang
YJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003990:Dibenzoxepins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D003990:Dibenzoxepins