[Cardioprotective effect of GABA derivatives in acute alcohol intoxication].
Cardioprotective properties of GABA analogs under conditions of acute alcoholic intoxication have been studied using the following functional tests: volume loads, tests for adrenoreactivity, and maximum isometric load. The experiments showed that a 32% aqueous ethanol solution intraperitoneally injected in a dose of 8 g/kg produces a cardiotoxic action, which is manifested by a decrease in the inotropic reserve in load tests. Citrocard (50 mg/kg), phenibut (50 mg/kg), and piracetam (200 mg/kg) prevent the alcohol-induced myocardium injury, as shown by the heart contractility retained on a higher level in the test group than in the control group.
Perfilova
V N
VN
Tiurenkov
I N
IN
Berestovitskaia
V M
VM
Vasil'eva
O S
OS
D000208:Acute Disease; D000435:Alcoholic Intoxication / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D000818:Animals; D002306:Cardiac Volume / Q000187:drug effects; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000473:pathology*; D010889:Piracetam / Q000627:therapeutic use*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D002316:Cardiotonic Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid; D010889:Piracetam