The missing link: chemokine receptors and tissue matrix breakdown in COPD.
Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease that is caused by cigarette smoke. The main characteristic of COPD is the continued inflammation caused by the sustained influx of macrophages and neutrophils into the lung. Recent studies have shed light on how these cells are attracted during acute and chronic inflammation of the lung. The factors involved might be both a biomarker and a therapeutic target in COPD.
Smit
Joost J
JJ
Department of Pathology, University of Michigan Medical School, 4620 BSRB 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. jetses@umich.edu
Lukacs
Nicholas W
NW
D000818:Animals; D002633:Chemotaxis; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism; D016676:Macrophages, Alveolar / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D019707:Receptors, Chemokine / Q000378:metabolism*; D023063:Receptors, Interleukin-8B / Q000378:metabolism
D010446:Peptide Fragments; D019707:Receptors, Chemokine; D023063:Receptors, Interleukin-8B