Mulberry extract supplements ameliorate the inflammation-related hematological parameters in carrageenan-induced arthritic rats.
Mulberry fruit (Morus Lhou Koidz.), a rich source of the major anthocyanin, cyanidin 3-glucoside (C3G), has traditionally been used for the treatment of inflammatory conditions including rheumatic arthritis. In this study, we evaluated the efficacy of orally administrated methanolic mulberry fruit extract (ME) in carrageenan-induced arthritic rats, based on previously observed in vitro antioxidant and anti-inflammatory activities. A significant attenuation of hind paw inflammation characterized by fluid accumulation, uric acid production, and rheumatoid factors induced by carrageenan was observed following the intake of both ME (50 mg/kg of body weight) and C3G (10 mg/kg of body weight). Moreover, alterations in hematological parameters such as serum triglyceride, high-density lipoprotein-cholesterol, and atherogenic index following carrageenan administration were partially reversed by the administration of ME. It is concluded that dietary mulberry fruit extracts elicited protection against carrageenan-induced inflammation.
Kim
Ae-Jung
AJ
Department of Food and Nutrition, Hyejoen College, Heongsung Gun, Chungnam, Republic of Korea.
Park
Soojin
S
D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D002097:C-Reactive Protein / Q000032:analysis; D002351:Carrageenan; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D019587:Dietary Supplements; D005638:Fruit / Q000737:chemistry*; D007958:Leukocyte Count; D008297:Male; D031625:Morus / Q000737:chemistry*; D009504:Neutrophils; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012217:Rheumatoid Factor / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010936:Plant Extracts; D014280:Triglycerides; D014527:Uric Acid; D002351:Carrageenan; D002097:C-Reactive Protein; D012217:Rheumatoid Factor