Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: multicentre study in Inuit and European populations.
Exposure to persistent organochlorine pollutants (POPs) may have negative impact on male reproductive function. We, therefore, investigated the association between serum levels of POPs and epididymal and accessory sex gland function. Serum levels of CB-153, p,p'-DDE and seminal markers of epididymal [neutral-alpha glucosidase (NAG)], prostatic [prostate specific-antigen (PSA)] and zinc, and seminal vesicle function (fructose) were measured from 135 Swedish fishermen and fertile men from Greenland (n=163), Warsaw, Poland (n=167) and Kharkiv, Ukraine (n=158). Multiple linear regression analyses, adjusting for potential confounders, were employed using both continuous and categorized exposure variables. Both exposure and outcome variables were log transformed. Considering the consistency between models with either continuous or categorized CB-153 levels, negative associations with the activity of NAG were found among Greenlandic men (mean difference 7.0 mU/ejaculate, 95% CI 3.0, 34), and in the aggregated cohort (mean difference 4.0 mU/ejaculate, 95% CI -0.2, 8.0). A positive association was observed between CB-153 and PSA as well as zinc among Kharkiv men. In the Swedish cohort, a negative association was found between CB-153 and fructose. In conclusion, the negative effects of POP on sperm motility, observed in the same study population might partly be caused by post-testicular mechanisms, involving a decreased epididymal function.
Elzanaty
Saad
S
Scanian Andrology Centre, Fertility Centre, Malmö University Hospital, Lund University, Malmö, Sweden. saad.elzanaty@kmed.lu.se
Rignell-Hydbom
Anna
A
Jönsson
Bo A G
BA
Pedersen
Henning S
HS
Ludwicki
Jan K
JK
Shevets
Maryna
M
Zvyezday
Valentyna
V
Toft
Gunnar
G
Bonde
Jens Peter
JP
Rylander
Lars
L
Hagmar
Lars
L
Bonefeld-Jorgensen
Ewa
E
Spano
Marcello
M
Bizzaro
Davide
D
Manicardi
Gian-Carlo
GC
Giwercman
Aleksander
A
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood / Q000506:poisoning*; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000097:blood / Q000506:poisoning*; D005260:Female; D005398:Fisheries; D005837:Genitalia, Male / Q000187:drug effects* / Q000502:physiology; D006116:Greenland; D006801:Humans; D004930:Inuit; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011044:Poland; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000633:toxicity; D011247:Pregnancy; D017430:Prostate-Specific Antigen / Q000032:analysis; D012661:Semen / Q000737:chemistry / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D014455:Ukraine; D044465:White People
D015415:Biomarkers; D004785:Environmental Pollutants; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls; D017430:Prostate-Specific Antigen; C014024:2,4,5,2',4',5'-hexachlorobiphenyl