[Serum organochlorines pesticides level of non-occupational exposure women and risk of breast cancer:a case-control study].
OBJECTIVE
To describe exposure level of organochlorines pesticides residues in non-occupational exposure population in China and testify the hypothesis that organochlorine pesticides exposure may be the risk factor to human breast cancer.


METHODS
A case-control study based on community was designed. 90 new diagnostic breast cancer patients from the Second Hospital of Sichuan Province, and 136 health women from community, who settled down in the same district as case were enrolled. The risk factors of breast cancer were investigated by a questionnaire. GC-ECD was used to measure the serum level of Organochlorines pesticide residues. The adjusted odds rations (OR) of organochlorines pesticides residues to breast cancer were evaluated by logistic regression model.


RESULTS
8 organochlorines pesticide residues including p, p'-DDT, p, p'-DDE, o, p'-DDT, p, p'-DDD and alpha, beta, gamma, delta-HCHs (hexachlorocyclohexane) could be detected in serum of cases and controls. The detecting rates of beta-HCH, p, p'-DDE and p, p'-DDT respectively were 91.2%, 92.1% and 91.2%. There were no significant differences of serum level of organochlorines pesticides residues between cases and controls (P > 0.05). After adjusting confounding factors, serum p,p'-DDT, p,p'-DDD, and delta-HCH level were positively related to the risk of breast cancer (adjusted OR > 2, P < 0.05) . High serum p,p'-DDT,p,p'-DDD and beta-HCH level were positively correlated to premenopausal women (adjusted ORs respectively were 3.59, 5.70 and 3.06, P < 0.05).


CONCLUSIONS
Organochlorines pesticides resides, including DDTs and HCHs, may increase women's risk of breast cancer, particularly in premenopausal women in China.
Li
Jia-yuan
JY
West China School of Public Health, Sichuan University, Chengdu 610041, China.
Li
Hui
H
Tao
Ping
P
Lei
Fang-ming
FM
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D002273:Carcinogens / Q000032:analysis; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003634:DDT / Q000097:blood; D052244:Endocrine Disruptors / Q000097:blood; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D016015:Logistic Models; D008875:Middle Aged; D010573:Pesticide Residues / Q000097:blood*; D012307:Risk Factors
D002273:Carcinogens; D052244:Endocrine Disruptors; D006843:Hydrocarbons, Chlorinated; D010573:Pesticide Residues; D003634:DDT