title: Przewalskin A: A new C23 terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii maxim.
abstract: Przewalskin A (1), a novel C23 terpenoid with a 6/6/7 carbon ring skeleton, was isolated from Salvia przewalskii. Its structure was determined by comprehensive 1D NMR, 2D NMR, and MS spectroscopic analysis and subsequently confirmed by a single-crystal X-ray diffraction study of its PDC oxidation derivative (2). Compounds 1 and 2 showed modest anti-HIV-1 activity with EC50 = 41 and 89 microg/mL, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PRC.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Liang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Ze-Yuan
authors.initials: ZY
authors.lastname: Liu
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D002244:Carbon / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D027544:Salvia / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry*
chemical_list: D003512:Cyclohexanones; D004224:Diterpenes; D013729:Terpenes; C520938:przewalskin A; D002244:Carbon