title: Treatment of peritoneal carcinomatosis by cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion (IHCP): postoperative outcome and risk factors for morbidity.
abstract: BACKGROUND
  Cytoreductive surgery with limited or extended peritonectomy associated with intraperitoneal hyperthermic chemoperfusion (IHCP) has been proposed for treatment of peritoneal carcinomatosis (PC) from abdominal neoplasms.
  
  
  METHODS
  Fifty-nine patients with PC from abdominal neoplasms underwent 61 treatments using this technique from January 2000 to August 2005. Surgical debulking, completed by partial or total peritonectomy, was performed in most cases. In 16 patients with positive peritoneal cytology without macroscopic peritoneal disease, IHCP was performed in order to prevent peritoneal recurrence. IHCP was carried out throughout the abdominopelvic cavity for 60 minutes using a closed abdomen technique. Intra-abdominal temperature ranged between 41 degrees C and 43 degrees C; mitomycin C (25 mg/mq) and cisplatin (100 mg/mq) were the anticancer drugs generally used, and they were administered with a flow rate of 700-800 ml/minute.
  
  
  RESULTS
  Mean hospital stay was 13 +/- 7 (range 7-49) days. Postoperative complications occurred in 27 patients (44.3%); of these, major morbidity was observed in 17 (27.9%). The most frequent complications were wound infection (9 cases), grade 2 or greater hematological toxicity (5 cases), intestinal fistula (5 cases), and pleural effusion requiring drainage (5 cases). Reoperation was necessary in 5 patients (8.2%). One patient with multiorgan failure died in the postoperative period (mortality rate: 1.6%). Multivariate analysis of several variables identified completeness of cancer resection (CCR-2/3 vs. CCR-0/1, relative risk: 9.27) and age (relative risk: 1.06 per year) as independent predictors of postoperative morbidity. Preliminary follow-up data indicate that survival probability may be high in patients with ovarian or colorectal cancer and low in patients with gastric cancer.
  
  
  CONCLUSIONS
  IHCP combined with cytoreductive surgery involves a high risk of morbidity, but postoperative complications could be resolved favorably in most cases with correct patient selection and adequate postoperative care. Tumor residual and advanced age significantly increase the risk of morbidity after this procedure.
authors.affiliation: Department of Human Pathology and Oncology, Advanced Surgical Oncology Unit, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy. roviello@unisi.it
authors.forename: Franco
authors.initials: F
authors.lastname: Roviello
authors.forename: Daniele
authors.initials: D
authors.lastname: Marrelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Neri
authors.forename: Daniela
authors.initials: D
authors.lastname: Cerretani
authors.forename: Giovanni
authors.initials: G
authors.lastname: de Manzoni
authors.forename: Corrado
authors.initials: C
authors.lastname: Pedrazzani
authors.forename: Tommaso
authors.initials: T
authors.lastname: Cioppa
authors.forename: Giacomo
authors.initials: G
authors.lastname: Nastri
authors.forename: Giorgio
authors.initials: G
authors.lastname: Giorgi
authors.forename: Enrico
authors.initials: E
authors.lastname: Pinto
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002277:Carcinoma / Q000556:secondary* / Q000628:therapy*; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000556:secondary* / Q000628:therapy*; D011183:Postoperative Complications / Q000453:epidemiology; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents