title: A case of haemangiopericytoma-associated hypoglycaemia: Beneficial effect of treatment with radiotherapy.
abstract: A 72-year-old lady presented with recurrent hypoglycaemia and a large pelvic mass. Hypoglycaemia was accompanied by undetectable serum insulin and c-peptide and high insulin-like growth factor II (IGFII) to IGFI ratio. She had undergone successful resection of a large bladder haemangiopericytoma 7 years earlier. A core biopsy was performed, and histology confirmed the recurrence of the haemangiopericytoma. Local palliative radiotherapy resulted in the reduction of IGFII level and IGFII to IGFI ratio and increased insulin, c-peptide and growth hormone (GH) level with long-term amelioration of hypoglycaemic episodes. Clinically and biochemically, radiotherapy was more effective than GH therapy.
authors.affiliation: Department of Medicine, Wirral Hospital NHS-Trust, Wirral, Cheshire, UK. hsoran@aol.com
authors.forename: H
authors.initials: H
authors.lastname: Soran
authors.forename: N
authors.initials: N
authors.lastname: Younis
authors.forename: F
authors.initials: F
authors.lastname: Joseph
authors.forename: Z
authors.initials: Z
authors.lastname: Hayat
authors.forename: H
authors.initials: H
authors.lastname: Zakhour
authors.forename: A
authors.initials: A
authors.lastname: Scott
mesh_terms: D000368:Aged; D005260:Female; D006393:Hemangiopericytoma / Q000150:complications / Q000532:radiotherapy*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D012008:Recurrence; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000532:radiotherapy*
chemical_list: D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II