title: Comparison of secular trends in pneumococcal serotypes causing invasive disease in Denver, Colorado (1971-2004) and serotype coverage by marketed pneumococcal vaccines.
abstract: Invasive pneumococcal isolates from three hospitals in Denver, CO, USA were serotyped between 1971 and 2004. Serotype 14 was most common (13.2%), and other prevalent serotypes (3, 4, 6, 9 and 19) together accounted for 44.1% of the isolates. All prevalent serotypes and 91.3% of the total isolates were covered by pneumococcal polysaccharide vaccine, while 79.1% of prevalent serotypes and 56.7% of total isolates were covered by pneumococcal conjugate vaccine. Serotypes 6, 9 and 14 were more common in the final decade than in the first decade studied (37.3% vs. 20.2%), whereas serotypes 3 and 23 were more common in the first decade (18.5% vs. 11.0%).
authors.affiliation: Zonguldak Karaelmas University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Zonguldak, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Akduman
authors.forename: J M
authors.initials: JM
authors.lastname: Ehret
authors.forename: F N
authors.initials: FN
authors.lastname: Judson
mesh_terms: D003120:Colorado / Q000453:epidemiology; D006786:Hospitals, Urban; D006801:Humans; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D022242:Pneumococcal Vaccines / Q000145:classification*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification*; D013997:Time Factors
chemical_list: D022242:Pneumococcal Vaccines