Contraception for women with epilepsy.
Antiepileptic drugs that induce hepatic enzyme activity may alter the metabolism of most hormonal methods of contraception, and this affects the contraceptive regime. This effect should be considered in the choice of both the treatment of the epilepsy and the choice of contraceptive method. This review considers these interactions and offers advice about their management.
O'Brien
Michael D
MD
Guy's Hospital, London, UK. obrmd@btinternet.com
Guillebaud
John
J
D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000627:therapeutic use; D002755:Choice Behavior; D003268:Contraception Behavior / Q000523:psychology*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics; D003282:Contraceptives, Postcoital, Hormonal / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics; D017135:Desogestrel / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy* / Q000523:psychology*; D005260:Female; D006801:Humans; D007434:Intrauterine Devices; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000378:metabolism
D000927:Anticonvulsants; D003271:Contraceptive Agents, Female; D003278:Contraceptives, Oral, Hormonal; D003282:Contraceptives, Postcoital, Hormonal; C044815:etonogestrel; D017135:Desogestrel; D017258:Medroxyprogesterone Acetate