Disturbed assembly of human cerebral microtubules in Alzheimer's disease.
It is shown for the first time that microtubular proteins isolated from the brain of patients with Alzheimer's disease can in vitro polymerize into microtubules with abnormal structure.
Shevtsov
P N
PN
Laboratory of Neurochemistry, National Center for Mental Health, Russian Academy of Medical Sciences. Ishev@ipac.ac.ru
Shevtsova
E F
EF
Burbaeva
G Sh
GSh
Bachurin
S O
SO
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure*; D014404:Tubulin / Q000378:metabolism
D008869:Microtubule-Associated Proteins; D014404:Tubulin