A lipoxygenase inhibitor in breast cancer brain metastases.
The complication of multiple brain metastases in breast cancer patients is a life threatening condition with limited success following standard therapies. The arachidonate lipoxygenase pathway appears to play a role in brain tumor growth as well as inhibition of apoptosis in in-vitro studies. The down regulation of these arachidonate lipoxygenase growth stimulating products therefore appeared to be a worthwhile consideration for testing in brain metastases not responding to standard therapy. Boswellia serrata, a lipoxygenase inhibitor was applied for this inhibition. Multiple brain metastases were successfully reversed using this method in a breast cancer patient who had not shown improvement after standard therapy. The results suggest a potential new area of therapy for breast cancer patients with brain metastases that may be useful as an adjuvant to our standard therapy.
Flavin
D F
DF
Foundation for Collaborative Medicine and Research, Greenwich, CT 06831, USA. Dana_FK@hotmail.com
D000328:Adult; D001091:Arachidonate Lipoxygenases / Q000187:drug effects* / Q000378:metabolism; D029743:Boswellia; D001932:Brain Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*; D005260:Female; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D008517:Phytotherapy; D012074:Remission Induction; D016896:Treatment Outcome
D016859:Lipoxygenase Inhibitors; D001091:Arachidonate Lipoxygenases