title: An open study of the comparative efficacy and safety of caspofungin and liposomal amphotericin B in treating invasive fungal infections or febrile neutropenia in patients with haematological malignancy.
abstract: In a clinical non-trial setting, the efficacy and safety of caspofungin was compared with liposomal amphotericin B for the management of febrile neutropenia or invasive fungal infections in 73 episodes in patients with haematological malignancy. There were fewer episodes of drug toxicity with caspofungin than liposomal amphotericin B (58.3 vs 83.7 %, P=0.02). The favourable response rate for episodes of febrile neutropenia treated with caspofungin or liposomal amphotericin B was similar at 37.5 and 53.8 %, respectively, but more breakthrough fungal infections occurred with caspofungin than with liposomal amphotericin B (33.3 vs 0 %, P<0.05) in these patients who did not receive antifungal prophylaxis. None of four episodes of candidaemia or hepatosplenic candidiasis responded to caspofungin compared with three of four episodes treated with liposomal amphotericin B. Mortality was significantly higher with caspofungin treatment compared with liposomal amphotericin B (6/24 vs 2/49, P=0.01), mainly due to an excess of fungal infections (P=0.04). Caspofungin treatment was a significant independent predictor of mortality [odds ratio=7.6 (95 % confidence interval 1.2-45.5)] when sepsis severity, prolonged neutropenia and length of antifungal therapy were considered in a multiple logistic regression model. In clinical practice, there is a suggestion that caspofungin may not be as effective as liposomal amphotericin B in preventing breakthrough invasive fungal infections in febrile neutropenia or in preventing fungus-related deaths. Because of the potential biases in this observational study, these preliminary findings should be interpreted with caution and clarified with a larger cohort of patients.
authors.forename: Michael
authors.initials: M
authors.lastname: Ellis
authors.forename: Chris
authors.initials: C
authors.lastname: Frampton
authors.affiliation: Pulmonary and Critical Care Division, UCSF Fresno School of Medicine, 445 S Cedar Ave., Fresno, CA 93702, USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Joseph
authors.forename: Hussain
authors.initials: H
authors.lastname: Alizadeh
authors.forename: Jorgen
authors.initials: J
authors.lastname: Kristensen
authors.forename: Anders
authors.initials: A
authors.lastname: Hauggaard
authors.forename: Fuad
authors.initials: F
authors.lastname: Shammas
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077336:Caspofungin; D054714:Echinocandins; D005260:Female; D005334:Fever / Q000473:pathology; D019337:Hematologic Neoplasms / Q000150:complications*; D006761:Hospitals; D006801:Humans; D055666:Lipopeptides; D008081:Liposomes; D016015:Logistic Models; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000209:etiology*; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D010456:Peptides, Cyclic / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014479:United Arab Emirates
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008081:Liposomes; D010456:Peptides, Cyclic; D000666:Amphotericin B; D000077336:Caspofungin