Effect of Gutai Decoction on the abortion rate of in vitro fertilization and embryo transfer.
OBJECTIVE
To study the effect of Chinese herbal medicine Gutai Decoction (GTD) on the abortion rate of in vitro fertilization and embryo transfer (IVF-ET).


METHODS
Observed were two hundred and forty-seven women having received IVF-ET and with beta-human chorionic gonadotropin (beta-HCG) > 25 IU/L on the 14th day after transferring. All were treated conventionally with progesterone 20 - 80 mg per day after transferring and if necessary the treatment was supplemented with Progynova 2 - 4 mg per day, with the medication withdrawn gradually from the 9th week of pregnancy till stopped completely. Among them 131 cases received GTD medication additionally, for 109 cases of whom the medication started from the 2nd day of transferring (taken as Group A) and for the other 22 cases from the 14th day after transferring (taken as Group B), the other 116 cases with no additional GTD treatment given were taken as the control group, with the medication lasting to the 12th week. The abortion rate in them was observed.


RESULTS
The abortion rate in Group A, Group B and the control group was 12.84%, 13.64% and 23.28%, respectively, the difference between the GTD treated groups and the control group was significant (P < 0.05).


CONCLUSIONS
Chinese medicine GTD could reduce abortion rate in women receiving IVF-ET.
Liu
Ying
Y
Genetics and IVF Center of Guangdong Women and Children's Hospital, Guangzhou, China. ly1232005@126.com
Wu
Jing-zhi
JZ
D000028:Abortion, Induced; D000022:Abortion, Spontaneous / Q000188:drug therapy / Q000517:prevention & control*; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000008:administration & dosage; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D004624:Embryo Transfer; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic; D011272:Pregnancy, Multiple; D011374:Progesterone / Q000008:administration & dosage
D018997:Chorionic Gonadotropin, beta Subunit, Human; D004365:Drugs, Chinese Herbal; D011374:Progesterone; D004958:Estradiol