title: A pilot investigation comparing low-energy, double pass 1,450 nm laser treatment of acne to conventional single-pass, high-energy treatment.
abstract: OBJECTIVE
  Laser treatment using a 1,450 nm diode laser has been shown to improve acne and acne scarring. Its widespread adoption in younger populations has been significantly limited by discomfort.
  
  
  METHODS
  Six subjects with active papular acne were treated in a pilot study to determine parameters for a split-face, double-pass, low-energy protocol of 1,450 nm laser treatment. Sides of the face were randomized to receive single-pass, high-energy treatment (13-14 J/cm(2)), or double-pass, low energy treatment (8-11 J/cm(2)), for a total of four treatments delivered at monthly intervals. Acne counts and standardized, digital photograph were performed 2 months following the final treatment, and compared to pre-treatment counts and photographs.
  
  
  RESULTS
  Improvement was evaluated comparing pre- and post-treatment photos and averaged 2.5 for the high-energy, single-pass side and 2.3 for the low-energy, double-pass side, using a 0 (worse) to 4 (max improvement) scale. Acne counts were reduced 78% on the high-energy, single-pass side and 67% on the low-energy, double-pass side. Pain ratings on a 1 (min) to 10 (max) scale averaged 5.6 (range 1-9) for the high-energy, single-pass side and 1.3 (range 1-2) for the low-energy, double-pass side.
  
  
  CONCLUSIONS
  Low-energy, double-pass 1,450 nm laser treatment effectively reduces acne counts 2 months post-treatment, and dramatically reduces the pain associated with treatment. The treatment parameters used in this study have eliminated the need for anesthetic cream in daily practice.
authors.affiliation: Laser Surgery and Cosmetic Dermatology Centers, Bryn Mawr, PA 19010, USA. dermguy@hotmail.com
authors.forename: Eric F
authors.initials: EF
authors.lastname: Bernstein
mesh_terms: D000152:Acne Vulgaris / Q000145:classification / Q000532:radiotherapy*; D000328:Adult; D005260:Female; D006801:Humans; D053685:Laser Therapy; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D016896:Treatment Outcome