title: Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups--precursors to a variety of alpha-CF3-alpha-amino acid derivatives.
abstract: Convenient routes to methyl 2-oxalylimino- and 2-(phosphonoformimido)-3,3,3-trifluoropropanoates have been elaborated, based on the reaction of methyl trifluoropyruvate with ethyl oxamate or diethyl carbamoylphosphonate, respectively, followed by dehydration. The compounds obtained are useful synthetic intermediates toward a variety of novel 3,3,3-trifluoroalanine derivatives that are potential drug candidates.
authors.affiliation: Institute for Inorganic and Physical Chemistry, The University of Bremen, Leobener Str., D-28334, Germany.
authors.forename: Hanna
authors.initials: H
authors.lastname: Skarpos
authors.forename: Daria V
authors.initials: DV
authors.lastname: Vorob'eva
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Osipov
authors.forename: Irina L
authors.initials: IL
authors.lastname: Odinets
authors.forename: Eli
authors.initials: E
authors.lastname: Breuer
authors.forename: Gerd-Volker
authors.initials: GV
authors.lastname: Röschenthaler
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004583:Electrons; D007097:Imines / Q000737:chemistry*; D019289:Pyruvic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D007097:Imines; D019289:Pyruvic Acid