title: Treatment for obstructive sleep apnoea: effect on peripheral nerve function.
abstract: OBJECTIVE
  Obstructive sleep apnoea (OSA) is suggested to be associated with peripheral nerve damage. A case-control study was conducted to provide further support to this observation. In a longitudinal intervention study, it was examined whether treatment for OSA has a possible beneficial effect on peripheral nerve function.
  
  
  METHODS
  Participants were 23 patients with OSA and 23 controls matched for age and body mass index (BMI), all without any known cause of peripheral nerve damage. The sensory nerve action potential (SNAP) amplitudes of both sural nerves were determined. After 6 months of treatment for OSA, treatment compliance was evaluated and nerve conduction studies were repeated.
  
  
  RESULTS
  Patients with OSA had significantly lower mean (standard deviation) sural SNAP amplitudes than controls (6.3 (3.5) v 11.2 (5.0), p < 0.001). Multivariate regression analysis including the variables age, BMI and Apnoea-Hypopnea Index (AHI) showed that both age (p < 0.01) and AHI (p < 0.05) were inversely related to the SNAP amplitude. On follow-up, the sural SNAP showed an increase of 2.6 mV on average (p < 0.001). Multivariate regression analysis including the variables age, BMI, AHI, pretreatment SNAP and treatment compliance identified only treatment compliance as being significantly related to the SNAP increase (p < or = 0.005).
  
  
  CONCLUSIONS
  OSA is an independent risk factor for axonal dysfunction of peripheral sensory nerves. Impaired neural function is at least partly reversible with treatment for sleep apnoea.
authors.affiliation: Department of Neurology, University Hospital of Münster, Albert-Schweitzer-Strasse 33, 48129 Münster, Germany. dziewas@uni-muenster.de
authors.forename: Rainer
authors.initials: R
authors.lastname: Dziewas
authors.forename: Matthias
authors.initials: M
authors.lastname: Schilling
authors.forename: Philipp
authors.initials: P
authors.lastname: Engel
authors.forename: Matthias
authors.initials: M
authors.lastname: Boentert
authors.forename: Hyon
authors.initials: H
authors.lastname: Hor
authors.forename: Angelika
authors.initials: A
authors.lastname: Okegwo
authors.forename: Peter
authors.initials: P
authors.lastname: Lüdemann
authors.forename: E Bernd
authors.initials: EB
authors.lastname: Ringelstein
authors.forename: Peter
authors.initials: P
authors.lastname: Young
mesh_terms: D000200:Action Potentials; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000628:therapy*; D013497:Sural Nerve / Q000502:physiology; D016896:Treatment Outcome