Analgesic effect of corticotropin-releasing hormone: involvement of the hypothalamic-pituitary-adrenocortical axis into its realization.
Involvement of hypothalamic-pituitary-adrenocortical axis into the analgesic effect of corticotropin-releasing hormone after its systemic administration was studied in experiments on rats. Pharmacological blockade of the hypothalamic-pituitary-adrenocortical axis decreased the duration and degree of the analgesic effect of corticotropin-releasing hormone. This analgesic effect can be mediated via two pathways: related to hormones of the hypothalamic-pituitary-adrenocortical axis and independent of these hormones.
Bogdanov
A I
AI
Laboratory of Experimental Endocrinology, I P Pavlov Institute of Physiology, Russian Academy of Sciences, St Petersburg.
Yarushkina
N I
NI
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone