Improvements in motor behavioral tests during deep brain stimulation of the subthalamic nucleus in rats with different degrees of unilateral parkinsonism.
Deep brain stimulation (DBS) improves motor performance in Parkinson's disease (PD) patients. To evaluate the effects of subthalamic nucleus (STN)-DBS on impaired motor behavior, we studied improvements in motor performance after delivery of unilateral stimulation to the STN in rats with mild and severe lesions of the nigrostriatal dopamine system caused by injecting 6-hydroxydopamine into the striatum. The rats were trained and performed motor behavioral tests including rotational behavior test, stepping test, and rotarod test before and after receiving DBS. We demonstrated that stimulation at a current strength of 200 microA, which stopped most of the D-amphetamine-induced rotational behaviors in these two groups, improved movement impairments in both the mild and severe groups and that the improvements in the mild group were significantly better than those in the severe group. More experimental and clinical studies are needed to evaluate the efficiency of STN-DBS for different stages of PD.
Fang
Xin
X
Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
Sugiyama
Kenji
K
Akamine
Soichi
S
Namba
Hiroki
H
D000661:Amphetamine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D046690:Deep Brain Stimulation / Q000379:methods*; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy / Q000379:methods; D004566:Electrodes; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D045442:Rotarod Performance Test / Q000379:methods; D012399:Rotation; D020531:Subthalamic Nucleus / Q000503:physiopathology / Q000528:radiation effects*
D000697:Central Nervous System Stimulants; D016627:Oxidopamine; D000661:Amphetamine