title: Biomimetic synthesis of marine sponge metabolite spiculoic acid A and establishment of the absolute configuration of the natural product.
abstract: The synthesis of spiculoic acid A (1) using a biomimetic Diels-Alder reaction is described; comparison of the specific rotation of the natural and synthetic material revealed that the enantiomer of the natural product has been synthesized.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK OX1 3TA.
authors.forename: James E D
authors.initials: JE
authors.lastname: Kirkham
authors.forename: Victor
authors.initials: V
authors.lastname: Lee
authors.forename: Jack E
authors.initials: JE
authors.lastname: Baldwin
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation
chemical_list: D002264:Carboxylic Acids; D007189:Indans; C490145:spiculoic acid A