Presence of copper- and zinc-containing superoxide dismutase in commensal Haemophilus haemolyticus isolates can be used as a marker to discriminate them from nontypeable H. influenzae isolates.
Respiratory isolates of Haemophilus haemolyticus are regularly misclassified as nontypeable (NT) Haemophilus influenzae due to an aberrant hemolytic reaction on blood agar, with implications for treatment. The presence of sodC or its cognate protein, copper-zinc superoxide dismutase, can distinguish respiratory isolates of H. haemolyticus from NT H. influenzae with 100% accuracy.
Fung
W W Mary
WW
Department of Paediatrics, Division of Medicine, Imperial College, St Mary's Campus, London W2 1PG, United Kingdom.
O'Dwyer
Clíona A
CA
Sinha
Sunita
S
Brauer
Aimee L
AL
Murphy
Timothy F
TF
Kroll
J Simon
JS
Langford
Paul R
PR
D015415:Biomarkers; D006190:Haemophilus / Q000145:classification / Q000201:enzymology*; D006193:Haemophilus influenzae / Q000145:classification / Q000201:enzymology*; D006461:Hemolysis; D013482:Superoxide Dismutase / Q000032:analysis*
D015415:Biomarkers; D013482:Superoxide Dismutase