Microparticle-based technologies for vaccines.
Microparticles have been effectively used for many years as delivery systems for drugs and therapeutic proteins. Their application to the delivery of vaccines is not as extensive, but is growing. Utility has been demonstrated for the delivery of various types of vaccines (e.g., recombinant proteins, plasmid DNA, and peptides) and other vaccine components (e.g., immune potentiators). With respect to delivery of immune potentiators, synergistic effects are often observed whereby much more potent immune responses are induced with a combination than with either component alone. Hence, the prospects for broad application of microparticle-based delivery systems for vaccines are excellent.
O'Hagan
Derek T
DT
Vaccines Research, Novartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Mail Stop 4.3, Emeryville, CA 94608, USA.
Singh
Manmohan
M
Ulmer
Jeffrey B
JB
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000327:Adsorption; D004247:DNA / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D008863:Microspheres; D014612:Vaccines / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D014612:Vaccines; D004247:DNA