[Ischemic pre- and postconditioning].
One or several short cycles of ischemia/reperfusion before (preconditioning) or after (postconditioning) a sustained coronary occlusion with subsequent reperfusion reduce the ultimate infarct size. The protection is potent, but limited to a narrow time frame. In animal experiments a complex signal transduction cascade was identified which results specifically in a reduction of reperfusion injury. There is evidence for both ischemic pre-and postconditioning in patients with coronary artery disease.
Heusch
G
G
Institut für Pathophysiologie, Universitätsklinikum Essen. gerd.heusch@uni-essen.de
Schulz
R
R
D000818:Animals; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000379:methods*; D015398:Signal Transduction