title: Rapamycin biosynthesis: Elucidation of gene product function.
abstract: The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene complementation.
authors.affiliation: Biotica, Chesterford Research Park, Little Chesterford, UK CB10 1XL.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Gregory
authors.forename: Hui
authors.initials: H
authors.lastname: Hong
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Lill
authors.forename: Sabine
authors.initials: S
authors.lastname: Gaisser
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Petkovic
authors.forename: Lindsey
authors.initials: L
authors.lastname: Low
authors.forename: Lesley S
authors.initials: LS
authors.lastname: Sheehan
authors.forename: Isabelle
authors.initials: I
authors.lastname: Carletti
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Ready
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ward
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Kaja
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Weston
authors.forename: Iain R
authors.initials: IR
authors.lastname: Challis
authors.forename: Peter F
authors.initials: PF
authors.lastname: Leadlay
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Martin
authors.forename: Barrie
authors.initials: B
authors.lastname: Wilkinson
authors.forename: Rose M
authors.initials: RM
authors.lastname: Sheridan
mesh_terms: D005796:Genes; D005816:Genetic Complementation Test; D013058:Mass Spectrometry; D020123:Sirolimus / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020123:Sirolimus