title: [An analysis of the relationship between HBV DNA and HBeAg expression and mortality in 799 severe hepatitis patients].
abstract: OBJECTIVE
  To evaluate the relationship between mortality and HBVDNA and HBeAg expression of severe hepatitis B patients.
  
  
  METHODS
  The mortality rates of different types of severe hepatitis patients in our hospital during the last five years were analysed. HBV DNA was detected using the fluorescence quantitative PCR method and the HBeAg expression of severe hepatitis B was studied using a microparticle method.
  
  
  RESULTS
  (1) Hepatitis B morbidity was 83.5% in each type of severe hepatitis, and severe chronic hepatitis B morbidity was 96.77% in each type of severe chronic hepatitis. (2) The mortality rate of those with HBV DNA more than 1 x 10(5) copies/ml was 53.25% and the mortality of those with HBV DNA less than 1 x 10(5) copies/ml was 34.50% (P less than 0.01). The HBeAg expression had no influence on the death rate. (3) The death rate descended to 30.38% from 54.64% (HBV DNA more than 1 x 10(5) copies/ml) when treated with Lamivudine (P less than 0.01).
  
  
  CONCLUSIONS
  In severe hepatitis the quantity of virus carried in the patient is one of the key factors of mortality; antivirus treatment can lower mortality.
authors.affiliation: Department of Infectious Diseases, Beijing Ditan Hospital, Beijing 100011, China.
authors.forename: Rong-bing
authors.initials: RB
authors.lastname: Wang
authors.forename: Gui-qin
authors.initials: GQ
authors.lastname: Zhou
authors.forename: Yu-yong
authors.initials: YY
authors.lastname: Jiang
authors.forename: Feng-xia
authors.initials: FX
authors.lastname: Sun
authors.forename: Yun-zhong
authors.initials: YZ
authors.lastname: Wu
authors.forename: Jing-yuan
authors.initials: JY
authors.lastname: Sun
authors.forename: Pei-pei
authors.initials: PP
authors.lastname: Meng
authors.forename: Si-meng
authors.initials: SM
authors.lastname: Niu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004279:DNA, Viral; D005260:Female; D006514:Hepatitis B Surface Antigens; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens