title: Assessment of antidiarrhoeal activity of the methanol extract of Xylocarpus granatum bark in mice model.
abstract: The methanol extract of Xylocarpus granatum bark was studied for its antidiarrhoeal properties in experimental diarrhoea, induced by castor oil and magnesium sulphate in mice. At the doses of 250 and 500 mg/kg per oral, the methanol extract showed significant and dose-dependent antidiarrhoeal activity in both models. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to atropine sulphate (5 mg/kg; i.m.). The results showed that the extracts of Xylocarpus granatum bark have a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.
authors.affiliation: Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh.
authors.forename: Razina
authors.initials: R
authors.lastname: Rouf
authors.forename: Shaikh Jamal
authors.initials: SJ
authors.lastname: Uddin
authors.forename: Jamil Ahmad
authors.initials: JA
authors.lastname: Shilpi
authors.forename: Mahiuddin
authors.initials: M
authors.lastname: Alamgir
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D001459:Bangladesh; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D008278:Magnesium Sulfate; D008297:Male; D008519:Medicine, Traditional; D029582:Meliaceae / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D008278:Magnesium Sulfate; D002368:Castor Oil; D000432:Methanol