title: CyberKnife radiosurgery and rituximab in the successful management of sclerosing idiopathic orbital inflammatory disease.
abstract: A 26-year-old man presented with symptoms suggesting idiopathic orbital inflammatory disease. After a poor initial response to oral steroids, an orbital biopsy confirmed the diagnosis. A paucicellular lymphocytic infiltrate with areas of fibrosis was seen to replace normal tissue. With the development of exposure keratopathy and diplopia associated with eyelid retraction, lagophthalmos, and decreased motility, increasing doses of steroids and intralesional steroid injections were instituted without effect. On the basis of successful treatment of malignant lymphocytic lesions, he was treated with CyberKnife radiosurgery and rituximab. This resulted in symptom resolution with improved eyelid closure and motility. Eighteen months after treatment, he is essentially symptom-free, with almost complete radiographic regression of his disease process.
authors.affiliation: Sinai Hospital of Baltimore, Krieger Eye Institute, Baltimore, Maryland 21215, USA.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: On
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Hirschbein
authors.forename: H James
authors.initials: HJ
authors.lastname: Williams
authors.forename: James W
authors.initials: JW
authors.lastname: Karesh
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001706:Biopsy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D016727:Orbital Pseudotumor / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D016634:Radiosurgery / Q000295:instrumentation*; D000069283:Rituximab; D012598:Sclerosis; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab