title: Ring expansion/homologation--aldehyde condensation cascade using tert-trihalomethylcarbinols.
abstract: Treatment of cyclic tert-trihalomethylcarbinols with CrCl(2) in THF/HMPA in the presence of aryl or aliphatic aldehydes initiates a cascade sequence of one carbon ring expansion-olefination affording conjugated exocyclic ketones. Acyclic tert-trihalomethylcarbinols undergo a comparable cascade of one carbon homologation-olefination.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. j.falck@utsouthwestern.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Falck
authors.forename: Anyu
authors.initials: A
authors.lastname: He
authors.forename: L Manmohan
authors.initials: LM
authors.lastname: Reddy
authors.forename: Abhijit
authors.initials: A
authors.lastname: Kundu
authors.forename: Deb K
authors.initials: DK
authors.lastname: Barma
authors.forename: A
authors.initials: A
authors.lastname: Bandyopadhyay
authors.forename: Sukanta
authors.initials: S
authors.lastname: Kamila
authors.forename: Radha
authors.initials: R
authors.lastname: Akella
authors.forename: Romain
authors.initials: R
authors.lastname: Bejot
authors.forename: Charles
authors.initials: C
authors.lastname: Mioskowski
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D003500:Cyclization; D000432:Methanol / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000432:Methanol