Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives.
To investigate the little known risk of lung cancer at an early age when a first-degree relative has had such a diagnosis, 579 incident cases and 1157 population controls were studied in Liverpool between 1998 and 2004 using standardised questionnaires covering demography and lifestyle. A history of lung cancer in first-degree relatives was associated with a significantly increased risk in the proband where in both individuals the cancers were diagnosed before the age of 60 years (odds ratio (OR)=4.89; 95% confidence interval (CI): 1.47-16.25). A significantly elevated risk of lung cancer was also observed in association with a relative affected before the age of 60 years, regardless of age-at-onset of the disease (OR=2.08; 95% CI: 1.20-3.59). This finding is strongly consistent with a genetic component in early-onset lung cancer risk.
Cassidy
A
A
Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK.
Myles
J P
JP
Duffy
S W
SW
Liloglou
T
T
Field
J K
JK
D017668:Age of Onset; D000368:Aged; D016022:Case-Control Studies; D005192:Family Health; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D012923:Social Class; D013997:Time Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D006113:United Kingdom / Q000453:epidemiology
D014028:Tobacco Smoke Pollution