title: Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: multicentre study in Inuit and European populations.
abstract: Exposure to persistent organochlorine pollutants (POPs) may have negative impact on male reproductive function. We, therefore, investigated the association between serum levels of POPs and epididymal and accessory sex gland function. Serum levels of CB-153, p,p'-DDE and seminal markers of epididymal [neutral-alpha glucosidase (NAG)], prostatic [prostate specific-antigen (PSA)] and zinc, and seminal vesicle function (fructose) were measured from 135 Swedish fishermen and fertile men from Greenland (n=163), Warsaw, Poland (n=167) and Kharkiv, Ukraine (n=158). Multiple linear regression analyses, adjusting for potential confounders, were employed using both continuous and categorized exposure variables. Both exposure and outcome variables were log transformed. Considering the consistency between models with either continuous or categorized CB-153 levels, negative associations with the activity of NAG were found among Greenlandic men (mean difference 7.0 mU/ejaculate, 95% CI 3.0, 34), and in the aggregated cohort (mean difference 4.0 mU/ejaculate, 95% CI -0.2, 8.0). A positive association was observed between CB-153 and PSA as well as zinc among Kharkiv men. In the Swedish cohort, a negative association was found between CB-153 and fructose. In conclusion, the negative effects of POP on sperm motility, observed in the same study population might partly be caused by post-testicular mechanisms, involving a decreased epididymal function.
authors.affiliation: Scanian Andrology Centre, Fertility Centre, Malmö University Hospital, Lund University, Malmö, Sweden. saad.elzanaty@kmed.lu.se
authors.forename: Saad
authors.initials: S
authors.lastname: Elzanaty
authors.forename: Anna
authors.initials: A
authors.lastname: Rignell-Hydbom
authors.forename: Bo A G
authors.initials: BA
authors.lastname: Jönsson
authors.forename: Henning S
authors.initials: HS
authors.lastname: Pedersen
authors.forename: Jan K
authors.initials: JK
authors.lastname: Ludwicki
authors.forename: Maryna
authors.initials: M
authors.lastname: Shevets
authors.forename: Valentyna
authors.initials: V
authors.lastname: Zvyezday
authors.forename: Gunnar
authors.initials: G
authors.lastname: Toft
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Bonde
authors.forename: Lars
authors.initials: L
authors.lastname: Rylander
authors.forename: Lars
authors.initials: L
authors.lastname: Hagmar
authors.forename: Ewa
authors.initials: E
authors.lastname: Bonefeld-Jorgensen
authors.forename: Marcello
authors.initials: M
authors.lastname: Spano
authors.forename: Davide
authors.initials: D
authors.lastname: Bizzaro
authors.forename: Gian-Carlo
authors.initials: GC
authors.lastname: Manicardi
authors.forename: Aleksander
authors.initials: A
authors.lastname: Giwercman
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood / Q000506:poisoning*; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000097:blood / Q000506:poisoning*; D005260:Female; D005398:Fisheries; D005837:Genitalia, Male / Q000187:drug effects* / Q000502:physiology; D006116:Greenland; D006801:Humans; D004930:Inuit; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011044:Poland; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000633:toxicity; D011247:Pregnancy; D017430:Prostate-Specific Antigen / Q000032:analysis; D012661:Semen / Q000737:chemistry / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D014455:Ukraine; D044465:White People
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls; D017430:Prostate-Specific Antigen; C014024:2,4,5,2',4',5'-hexachlorobiphenyl