title: [Effects of extracts from different parts of Folium perillae (L.) Britt. on Hemorrheological parameters in rats].
abstract: In order to provide experimental data for the development and application of drug in clinic, we determined the effects of extracts from different parts of folium perillae (L. ) Britt. on hemorheological parameters, extracted from leaves (folium perillae), seeds (fructus perillae) and peduncles (caulis perillae). The results showed that all extracts from different parts of folium perillae (L. ) Britt. can significantly reduce the whole blood viscosity at low shear rate (10 s(-1)), erythrocyte aggregation index, erythrocyte electrophoresis index (P<0.05), and the whole blood reductive viscosity at low shear rate (10 s(-1)) (P<0.01). Extracts from folium perillae and caulis perillae can significantly decrease erythrocyte deformation index (P<0.05), whereas extracts from fructus perillae can not. Extracts from fructus perillae and caulis perillae can significantly decrease plasma viscosity at low shear rate(10 s(-1)), but extracts of folium perillae can not. Aspirin can only decrease the whole blood reductive viscosity at low shear rate and plasma viscosity (P<0.05). All extracts from different parts of folium perillae (L. ) Britt. had no significant effects on hematocrit, erythrocyte rigidity index, fibrinogen concentration , the whole blood viscosity and the whole blood reductive viscosity at middle and high shear rate (60 s(-1),120 s(-1)).
authors.affiliation: Key Lab for Biomechanics & Tissue Engineering of Ministry of Education, Chongqing University, China.
authors.forename: Zaipin
authors.initials: Z
authors.lastname: Xu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Deng
authors.forename: Jiying
authors.initials: J
authors.lastname: Men
authors.forename: Xuejian
authors.initials: X
authors.lastname: Feng
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Lu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Yang
authors.forename: Biqiong
authors.initials: B
authors.lastname: Yao
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D008297:Male; D031344:Perilla frutescens / Q000033:anatomy & histology / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry
chemical_list: D010936:Plant Extracts