title: First asymmetric total syntheses of (-)-subincanadines a and B, skeletally rearranged pentacyclic monoterpenoid indole alkaloids in aspidospermasubincanum.
abstract: We achieved the first asymmetric total syntheses of novel Aspidosperma indole alkaloids, (-)-subincanadines A and B, which involve an intramolecular diastereoselective Pictet-Spengler cyclization and an intramolecular Nozaki-Hiyama-Kishi reaction as key steps in the total syntheses.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
mesh_terms: D030009:Aspidosperma / Q000737:chemistry*; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D026121:Indole Alkaloids; C472460:subincanadine A; C472461:subincanadine B