title: Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol.
abstract: OBJECTIVE
  To investigate whether dorzolamide modifies peripapillary retinal haemodynamics in juvenile primary open-angle glaucoma (JPOAG) patients treated with timolol.
  
  
  METHODS
  In 40 JPOAG subjects, before and after dorzolamide coadministration with timolol, the following examinations were achieved: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), heart rate (HR), visual field and retinal flowmetry.
  
  
  RESULTS
  Adjunctive therapy with dorzolamide induced the following modifications: IOP reduction [1.75 mmHg, 95% confidence interval (CI) 1.23, 2.26; P < 0.05], OPP increase (5.09 mmHg, 95% CI 2.97, 7.20; P < 0.02) and retinal blood flow improvement (35.0 arbitrary units, 95% CI 12.20, 57.80; P < 0.03). BP, HR and visual field indices did not change.
  
  
  CONCLUSIONS
  Dorzolamide, in association or in fixed combination with timolol, significantly improves retinal blood flow in JPOAG patients.
authors.affiliation: Department of Ophthalmology, University of Ferrara, Ferrara, Italy. ciro.costagliola@unife.it
authors.forename: Ciro
authors.initials: C
authors.lastname: Costagliola
authors.forename: Claudio
authors.initials: C
authors.lastname: Campa
authors.forename: Francesco
authors.initials: F
authors.lastname: Parmeggiani
authors.forename: Carlo
authors.initials: C
authors.lastname: Incorvaia
authors.forename: Paolo
authors.initials: P
authors.lastname: Perri
authors.forename: Sergio
authors.initials: S
authors.lastname: D'Angelo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lamberti
authors.forename: Adolfo
authors.initials: A
authors.lastname: Sebastiani
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D013449:Sulfonamides / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; D013999:Timolol; C062765:dorzolamide