In vitro and in vivo effects of ferulic acid on gastrointestinal motility: inhibition of cisplatin-induced delay in gastric emptying in rats.
OBJECTIVE
To study the effects of ferulic acid on gastrointestinal motility both in vitro and in vivo.


METHODS
Ferulic acid induced concentration-dependent stimulation of the basal tone of isolated guinea pig ileum (2-20 micromol/L) and isolated rat fundus (0.05-0.4 mmol/L).


RESULTS
Ferulic acid significantly accelerated the gastrointestinal transit and gastric emptying in rats in a dose-dependent manner (50-200 mg/kg, po). Cisplatin (2.5-20 mg/kg, ip) induced a dose-dependent delay in gastric emptying in rats. Pretreatment with ferulic acid dose-dependently, significantly reversed the cisplatin-induced delay in gastric emptying.


CONCLUSIONS
The endogenous prostaglandins (PGs) are involved in mediating the stimulant effects of ferulic acid. This effect of dietary ferulic acid may help improve other accompanying gastrointestinal symptoms such as abdominal discomfort and also may protect against emesis induced by cytotoxic drugs.
Badary
Osama A
OA
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt. obadary@yahoo.com
Awad
Azza S
AS
Sherief
Mohey A
MA
Hamada
Farid M A
FM
D000818:Animals; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D002756:Cholagogues and Choleretics; D003373:Coumaric Acids; D011453:Prostaglandins; C004999:ferulic acid; D002945:Cisplatin