Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions.
Benfield
Aaron P
AP
Department of Chemistry and Biochemistry and The Institute of Cellular and Molecular Biology, University of Texas at Austin, 1 University Station, A5300, 78712-1167, USA.
Teresk
Martin G
MG
Plake
Hilary R
HR
DeLorbe
John E
JE
Millspaugh
Laura E
LE
Martin
Stephen F
SF
D000595:Amino Acid Sequence; D019277:Entropy; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
D008024:Ligands; D011506:Proteins