Double roles of hydroxycinnamic acid derivatives in protection against lysozyme oxidation.
Oxidative damage to protein has been implicated in a number of diseases. Much interest has been focused on preventing oxidative damage to protein. Here we showed that hydroxycinnamic acid derivatives (HCA) were able to inhibit the cross-linking of protein induced by riboflavin-mediated photooxidation. HCA were also found to strongly protect lysozyme from gamma rays irradiation. The antioxidative properties of HCA were further studied by laser flash photolysis. Mechanism of antioxidant activities of HCA on lysozyme oxidation was discussed. HCA were found to protect protein against oxidation by scavenging oxidizing species and repairing the damaged protein.
Zhu
Hongping
H
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
Chen
Shimou
S
Hao
Shumei
S
Zhang
Zhaoxia
Z
Wang
Wenfeng
W
Yao
Side
S
D003373:Coumaric Acids / Q000378:metabolism*; D017665:Hydroxyl Radical / Q000378:metabolism; D009113:Muramidase / Q000378:metabolism*; D010084:Oxidation-Reduction; D010777:Photochemistry
D003373:Coumaric Acids; D017665:Hydroxyl Radical; D009113:Muramidase