Enhanced antiscrapie effect using combination drug treatment.
Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.
Kocisko
David A
DA
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. DKocisko@niaid.nih.gov
Caughey
Byron
B
Morrey
John D
JD
Race
Richard E
RE
D000818:Animals; D006224:Cricetinae; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D051379:Mice; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000627:therapeutic use; D011166:Porphyrins / Q000008:administration & dosage / Q000627:therapeutic use; D012608:Scrapie / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D016896:Treatment Outcome
D011166:Porphyrins; C016136:tetraphenylporphine sulfonate; D010426:Pentosan Sulfuric Polyester