[A IL-6R antagonist 2520A produced by a fungal species].
OBJECTIVE
To isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus.


METHODS
Various column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity. The spectral data and physic-chemical properties were measured for structure identification.


RESULTS
One compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus.


CONCLUSIONS
2520A is a known compound (ferrichrome). It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.
Zhu
Feng-chang
FC
Institute of Medical Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Jiang
Rong
R
Zhang
Yang
Y
Wu
Jian-bo
JB
Li
Yuan
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005285:Fermentation; D005290:Ferric Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005291:Ferrichrome / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D003904:Mitosporic Fungi / Q000737:chemistry*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019947:Receptors, Interleukin-6 / Q000037:antagonists & inhibitors*
C526383:2520A compound; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D005290:Ferric Compounds; D010456:Peptides, Cyclic; D019947:Receptors, Interleukin-6; D005291:Ferrichrome