Anticaries potential of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice.
The objective of this research was to evaluate the anticaries potential of stabilized stannous fluoride and sodium hexametaphosphate dentifrice using a series of laboratory studies. In a study of fluoride uptake into demineralized enamel, the stannous fluoride/sodium hexametaphosphate dentifrice exhibited fluoride uptake comparable to the clinically proven stannous fluoride and silica dentifrice. Under lesion progression pH-cycling conditions, the stabilized stannous fluoride/sodium hexametaphosphate dentifrice was shown to protect teeth against lesion initiation and progression almost completely, and was comparable to conventional, clinically proven dentifrices. This series of well-controlled and validated in vitro studies demonstrates the anticaries potential of the stabilized stannous fluoride/sodium hexametaphosphate dentifrice. These in vitro results suggest that the stabilized stannous fluoride/sodium hexametaphosphate dentifrice may provide enhanced anticaries performance relative to a sodium fluoride control dentifrice. These results are reflective of the clinical benefits previously reported for stabilized stannous fluoride/sodium hexametaphosphate dentifrices.
Pfarrer
Aaron M
AM
The Procter & Gamble Company, Health Care Research Center, Mason, Ohio, USA.
McQueen
Christina M
CM
Lawless
Michelle A
MA
Rapozo-Hilo
Marcia
M
Featherstone
John D B
JD
D002327:Cariostatic Agents / Q000627:therapeutic use*; D003731:Dental Caries / Q000188:drug therapy*; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects*; D006244:Hardness / Q000187:drug effects; D006801:Humans; D010710:Phosphates / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000627:therapeutic use*; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*
D002327:Cariostatic Agents; D010710:Phosphates; D014002:Tin Fluorides; D014100:Toothpastes; C009285:sodium polymetaphosphate