CD4+/CD56+ haematodermic neoplasm: a preculsor haematological neoplasm that frequently first presents in the skin.
CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK cell lymphoma, is an aggressive and rare preculsor hematologic neoplasm recently recognized by the WHO-EORTC classification consensus for cutaneous lymphomas. The neoplasm tends to affect elderly patients, who usually present with skin lesions but often have a disseminated disease, including bone marrow involvement. Although the lesions are composed of cells with a lymphoblast-like morphology and an NK-cell phenotype, exhibiting a CD4+, CD56+ positive immunophenotype, recent studies support a relationship to plasmacytoid dendritic cells. Because of the rarity of this disease, we describe two patients suffering a CD4+/CD56+ hematodermic neoplasm.
Martín
J M
JM
Hospital Clínico Universitario, Dermatology, Valencia, Spain. jmmart@eresmas.com
Nicolau
M J
MJ
Galán
A
A
Ferrández-Izquierdo
A
A
Ferrer
A M
AM
Jordá
E
E
D000368:Aged; D015704:CD4 Antigens / Q000276:immunology*; D019002:CD56 Antigen / Q000276:immunology*; D019337:Hematologic Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D011693:Purpura / Q000473:pathology; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
D015704:CD4 Antigens; D019002:CD56 Antigen