title: Anticaries potential of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice.
abstract: The objective of this research was to evaluate the anticaries potential of stabilized stannous fluoride and sodium hexametaphosphate dentifrice using a series of laboratory studies. In a study of fluoride uptake into demineralized enamel, the stannous fluoride/sodium hexametaphosphate dentifrice exhibited fluoride uptake comparable to the clinically proven stannous fluoride and silica dentifrice. Under lesion progression pH-cycling conditions, the stabilized stannous fluoride/sodium hexametaphosphate dentifrice was shown to protect teeth against lesion initiation and progression almost completely, and was comparable to conventional, clinically proven dentifrices. This series of well-controlled and validated in vitro studies demonstrates the anticaries potential of the stabilized stannous fluoride/sodium hexametaphosphate dentifrice. These in vitro results suggest that the stabilized stannous fluoride/sodium hexametaphosphate dentifrice may provide enhanced anticaries performance relative to a sodium fluoride control dentifrice. These results are reflective of the clinical benefits previously reported for stabilized stannous fluoride/sodium hexametaphosphate dentifrices.
authors.affiliation: The Procter & Gamble Company, Health Care Research Center, Mason, Ohio, USA.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Pfarrer
authors.forename: Christina M
authors.initials: CM
authors.lastname: McQueen
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Lawless
authors.forename: Marcia
authors.initials: M
authors.lastname: Rapozo-Hilo
authors.forename: John D B
authors.initials: JD
authors.lastname: Featherstone
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use*; D003731:Dental Caries / Q000188:drug therapy*; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects*; D006244:Hardness / Q000187:drug effects; D006801:Humans; D010710:Phosphates / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000627:therapeutic use*; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D010710:Phosphates; D014002:Tin Fluorides; D014100:Toothpastes; C009285:sodium polymetaphosphate