title: [Effect of the concomitant administration of indomethacin or ibuprofen on amikacin pharmacokinetics in premature newborns].
abstract: OBJECTIVE
  To evaluate whether the concomitant administration of ibuprofen or indomethacin plus amikacin may alter the latter drug s pharmacokinetic parameters, and hence amikacin plasma levels.
  
  
  METHODS
  Retrospective cohort study performed by reviewing the medical records of premature children with persistent ductus arteriosus receiving amikacin and ibuprofen, or amikacin and indomethacin. They were divided up into three groups: group 1: treatment with amikacin went before indomethacin or ibuprofen; group 2: simultaneously treated with amikacin and indomethacin; group 3: simultaneously treated with amikacin and ibuprofen. Pharmacokinetic parameters, distribution volume, and amikacin clearance were measured using the PKS program (a non-linear regression method). Half life was determined from previous parameters.
  
  
  RESULTS
  Twenty-eight patients were included. No statistically significant differences were found among pharmacokinetic parameters corresponding to each study group.
  
  
  CONCLUSIONS
  Further studies are needed with a greater number of patients and currently recommended doses to assess the influence of indomethacin and ibuprofen in the pharmacokinetics of amikacin in premature children with persistent ductus arteriosus.
authors.affiliation: Servicios de Farmacia, Hospital Universitario La Fe, Avda. Campanar 21, 46009 Valencia, Spain. grueso_cri@gva.es
authors.forename: C
authors.initials: C
authors.lastname: Cuesta Grueso
authors.forename: A
authors.initials: A
authors.lastname: Gimeno Navarro
authors.forename: M R
authors.initials: MR
authors.lastname: Marqués Miñana
authors.forename: J E
authors.initials: JE
authors.lastname: Peris Ribera
authors.forename: F
authors.initials: F
authors.lastname: Morcillo Sopena
authors.forename: J L
authors.initials: JL
authors.lastname: Poveda Andrés
mesh_terms: D000583:Amikacin / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D015331:Cohort Studies; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D016861:Cyclooxygenase Inhibitors; D000583:Amikacin; D007052:Ibuprofen; D007213:Indomethacin