title: Delayed effects of enalapril on structural characteristics of the glomerular apparatus in the kidneys of NISAG rats.
abstract: Structural characteristics of renal glomeruli were studied in adult hypertensive NISAG rats (hereditary stress-induced hypertension) receiving antihypertensive drug enalapril, an inhibitor of angiotensin-converting enzyme, on days 28-58 of life. Treatment with enalapril (25 mg/kg perorally) in the early period of postnatal ontogeny produced delayed hypotensive and nephroprotective effects.
authors.affiliation: Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. e.e.filjushina@iph.ma.nsc.ru
authors.forename: E E
authors.initials: EE
authors.lastname: Filyushina
authors.forename: M D
authors.initials: MD
authors.lastname: Shmerling
authors.forename: V A
authors.initials: VA
authors.lastname: Lazarev
authors.forename: I I
authors.initials: II
authors.lastname: Buzueva
authors.forename: D R
authors.initials: DR
authors.lastname: Kudryashova
authors.forename: A L
authors.initials: AL
authors.lastname: Markel
authors.forename: G S
authors.initials: GS
authors.lastname: Yakobson
mesh_terms: D000367:Age Factors; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000150:complications; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004656:Enalapril