Upper gastrointestinal function and glycemic control in diabetes mellitus.
Recent evidence has highlighted the impact of glycemic control on the incidence and progression of diabetic micro- and macrovascular complications, and on cardiovascular risk in the non-diabetic population. Postprandial blood glucose concentrations make a major contribution to overall glycemic control, and are determined in part by upper gastrointestinal function. Conversely, poor glycemic control has an acute, reversible effect on gastrointestinal motility. Insights into the mechanisms by which the gut contributes to glycemia have given rise to a number of novel dietary and pharmacological strategies designed to lower postprandial blood glucose concentrations.
Chaikomin
Reawika
R
Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
Rayner
Christopher K
CK
Jones
Karen-L
KL
Horowitz
Michael
M
D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology*; D018450:Disease Progression; D005746:Gastric Emptying / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D007003:Hypoglycemia / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control; D041742:Upper Gastrointestinal Tract / Q000503:physiopathology*
D001786:Blood Glucose