Rational design of RGD-albumin conjugates for targeted delivery of the VEGF-R kinase inhibitor PTK787 to angiogenic endothelium.
Temming
Kai
K
Department of Pharmacokinetics and Drug Delivery, Groningen University Institute of Drug Exploration, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. k.temming@rug.nl
Lacombe
Marie
M
Schaapveld
Roel Q J
RQ
Orfi
László
L
Kéri
Gyorgy
G
Poelstra
Klaas
K
Molema
Grietje
G
Kok
Robbert J
RJ
D000418:Albumins / Q000737:chemistry*; D015195:Drug Design; D004730:Endothelium, Vascular / Q000187:drug effects*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry*; D010793:Phthalazines / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D000418:Albumins; D009842:Oligopeptides; D010793:Phthalazines; D011725:Pyridines; C404768:vatalanib; C047981:arginyl-glycyl-aspartic acid; D040262:Receptors, Vascular Endothelial Growth Factor