[Evaluation of some selected structural and functional parameters of red blood cells as oxidative stress markers in elderly people with primary hypertension].
The aim of the study was to evaluate the degree of membrane lipid peroxidation, internal microviscosity, activity of both total and Na+, K+ membrane ATP-ase and markers of oxidative damage of membrane protein in erythrocytes of elderly people with primary hypertension.


METHODS
The examination was performed on 50 people. The first group (HA) consisted of 15 elderly people with primary hypertension (mean age 71, 3 years old). The reference groups were formed with healthy elderly people (K1) (15 people, mean age 72, 4 years old) and younger healthy people (K2) (20 people, mean age 55, 3 years old).


RESULTS
Membrane lipid peroxidation of red blood cells was significantly increased in the group of elderly people with primary hypertension (HA). The lowest level of lipid peroxidation was observed in the (K2) normotensive group of younger people. Erythrocyte internal microviscosity was significantly higher in the group of healthy elderly people (K1) compared with the group of healthy younger people (K2). In HA group additional essential increase in microviscosity was observed in comparison with K1 and K2. The activity of both total and Na+, K+ membrane ATP-ase was significantly the highest in the group of younger people and the lowest in the group of elderly people with primary hypertension. In HA group increased damage of membrane protein was observed that was indicated by the reduced -SH group content and the increased value of W/S parameter in comparison with K1 and K2 groups.


CONCLUSIONS
The obtained results indicate that in the elderly people with accompanying primary hypertension the whole-body oxidative stress is increased, which may be indicated by structural and functional oxidative damage of red blood cells. These observations may be significant in the pathogenesis of hypertension complications. This observation may be important in the pathogenesis of hypertension complications in this period of life.
Kedziora-Kornatowska
Kornelia
K
Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra i Klinika Geriatrii. kikgeriat@cm.umk.pl
Kujawski
Krzysztof
K
Błaszczak
Robert
R
Rysz
Jacek
J
Markuszewski
Leszek
L
Koter
Maria
M
Duchnowicz
Piotr
P
Kornatowski
Tomasz
T
Olszewski
Robert
R
Kedziora
Józef
J
D000368:Aged; D015415:Biomarkers; D001809:Blood Viscosity; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
D015415:Biomarkers