title: [Case of intracranial hypotension responsive to oral prednisolone].
abstract: A 31-year-old female patient with headache and nausea was admitted to our hospital, although there were no apparent neurological abnormalities except headache. Cerebrospinal fluid (CSF) pressure was 40 mmH2O on the first lumbar puncture and CT showed some fluid in the left maxillary sinus. She gradually developed orthostatic headache despite antibiotics, hydration and analgesics. MRI showed diffuse meningeal thickening and enhancement. CSF pressure was 0 mmH2O on the second lumbar puncture and RI cisternography demonstrated early excretion to the kidneys. She was diagnosed with intracranial hypotension due to CSF leakage. An autologous 10ml blood patch on the lumbar epidural space did not relieve the orthostatic headache. However, headache disappeared one day after oral intake of 40mg prednisolone. During the next three months, oral prednisolone was tapered off. Three months after the onset of the illness, MRI did not show either meningeal thickening or enhancement. We concluded that oral prednisolone was effective in a case of intracranial hypotension.
authors.affiliation: Ishikawa Prefectural Central Hospital, Department of Neurology.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakajiri
authors.forename: Michiyo
authors.initials: M
authors.lastname: Ohtaki
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Yoshinaga
authors.forename: Shinji
authors.initials: S
authors.lastname: Uchiyama
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D019585:Intracranial Hypotension / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D009192:Myelography; D011239:Prednisolone / Q000008:administration & dosage*; D013353:Subdural Effusion / Q000150:complications; D016896:Treatment Outcome
chemical_list: D011239:Prednisolone