title: Infectious bronchitis virus: S1 gene characteristics of vaccines used in China and efficacy of vaccination against heterologous strains from China.
abstract: The entire S1 protein genes of eight infectious bronchitis (IB) vaccine strains used in China were compared with those of the IB virus isolates present in the field in China. The nucleotide and amino acid similarities between the eight IB vaccine strains and the field strain, tl/CH/LDT3/03, which was isolated from a teal (Anas sp.), were not more than 81.1% and 79.2%, respectively. Phylogenetic analysis based on the S1 genes showed that the vaccines and field strains belonged to different clusters and showed larger evolutionary distances, and indicated that they were of different genotypes. Four out of the eight vaccines, in addition to the Massachusetts type vaccine H120, were used for protection tests against challenge by the IB virus isolate tl/CH/LDT3/03. This revealed that each of the five IB vaccines induced poor protection against the teal isolate, as assessed by respiratory protection, clinical signs and mortality, indicating the necessity of developing vaccines from local strains for IB control in China.
authors.affiliation: Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China. swliu@hvri.ac.cn
authors.forename: Shengwang
authors.initials: S
authors.lastname: Liu
authors.forename: Jianfei
authors.initials: J
authors.lastname: Chen
authors.forename: Zongxi
authors.initials: Z
authors.lastname: Han
authors.forename: Qinxia
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yuhao
authors.initials: Y
authors.lastname: Shao
authors.forename: Xiangang
authors.initials: X
authors.lastname: Kong
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Tong
mesh_terms: D000818:Animals; D002645:Chickens / Q000276:immunology*; D002681:China / Q000453:epidemiology; D018352:Coronavirus Infections / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D001351:Infectious bronchitis virus / Q000145:classification* / Q000235:genetics / Q000276:immunology*; D010802:Phylogeny; D011201:Poultry Diseases / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology*; D013047:Specific Pathogen-Free Organisms; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000235:genetics* / Q000276:immunology*
chemical_list: D014765:Viral Vaccines