title: Duplication, divergence and formation of novel protein topologies.
abstract: The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work explored one possible underlying mechanism called permutation-by-duplication, which produces special forms of motif rearrangements called circular permutations. Permutation-by-duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence.
authors.affiliation: Institute for Cellular and Molecular Biology, University of Texas at Austin, TX, USA. cvogel@mail.utexas.edu
authors.forename: Christine
authors.initials: C
authors.lastname: Vogel
authors.forename: Veronica
authors.initials: V
authors.lastname: Morea
mesh_terms: D020816:Amino Acid Motifs; D019020:Directed Molecular Evolution; D019143:Evolution, Molecular; D020440:Gene Duplication; D050939:Gene Fusion; D014644:Genetic Variation; D008957:Models, Genetic; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D011506:Proteins