title: Neuropeptide Y (NPY) modulates oxidative burst and nitric oxide production in carrageenan-elicited granulocytes from rat air pouch.
abstract: We studied the effects of neuropeptide Y (NPY) and NPY-related receptor specific peptides on functions of carrageenan-elicited granulocytes in vitro and ability of NPY to modulate carrageenan-induced air pouch inflammation in rats in vivo. Anti-inflammatory effect of NPY comprises reduced granulocyte accumulation into the air pouch, to some extent attenuation of phagocytosis, attained via Y1 receptor, and considerable decrease in peroxide production, albeit mediated via Y2 and Y5 receptors activation. Conversely, NPY increases nitric oxide production and this potentiation is mediated via Y1 receptor. It is concluded that NPY Y1 and Y2/Y5 receptors' interaction participates in NPY-induced modulation of granulocyte functions related to inflammation.
authors.affiliation: Immunology Research Center "Branislav Janković", Institute of Immunology and Virology "Torlak", Vojvode Stepe 458, 11152 Belgrade, Serbia. ilijadim@sezampro.yu
authors.forename: Mirjana
authors.initials: M
authors.lastname: Dimitrijević
authors.forename: Stanislava
authors.initials: S
authors.lastname: Stanojević
authors.forename: Stana
authors.initials: S
authors.lastname: Mićić
authors.forename: Vesna
authors.initials: V
authors.lastname: Vujić
authors.forename: Vesna
authors.initials: V
authors.lastname: Kovacević-Jovanović
authors.forename: Katarina
authors.initials: K
authors.lastname: Mitić
authors.forename: Stephan
authors.initials: S
authors.lastname: von Hörsten
authors.forename: Dusko
authors.initials: D
authors.lastname: Kosec
mesh_terms: D000818:Animals; D002351:Carrageenan / Q000008:administration & dosage*; D006098:Granulocytes / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000502:physiology*; D009478:Neuropeptide Y / Q000502:physiology*; D009569:Nitric Oxide / Q000096:biosynthesis*; D051381:Rats; D016897:Respiratory Burst / Q000502:physiology*; D012867:Skin / Q000378:metabolism / Q000473:pathology
chemical_list: D018836:Inflammation Mediators; D009478:Neuropeptide Y; D009569:Nitric Oxide; D002351:Carrageenan