Acute necrotizing encephalopathy of childhood in non-Asian patients: report of three cases and literature review.
Acute necrotizing encephalopathy of childhood is a novel type of parainfectious encephalopathy with a racial and geographic predilection, rarely reported from other than East Asian areas. The objective was to describe the clinical, imaging, and other laboratory findings of non-Asian patients with acute necrotizing encephalopathy. Data were collected from three patients diagnosed in Athens over a 4-year period plus 16 cases reported from other European and North American countries. One of the Greek children died, and the other two had a normal outcome. A neuropathologic examination in the fatal case showed edematous necrosis without inflammatory, reactive, or proliferative changes. Data from Greek and other non-Asian patients support the homogeneity of the disease worldwide.
Mastroyianni
Sotiria D
SD
Department of Neurology, University of Athens, Athens, Greece. smastr@otenet.gr
Gionnis
Dimitrios
D
Voudris
Konstantinos
K
Skardoutsou
Angeliki
A
Mizuguchi
Masashi
M
D002648:Child; D005260:Female; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000208:ethnology / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D019579:Neocortex / Q000473:pathology*; D012196:Review Literature as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods; D044465:White People