title: [Bupropion use for smoking cessation in HIV-infected patients receiving antiretroviral therapy].
abstract: Smoking is the most important modifiable cardiovascular risk factor. Bupropion administration is an effective method to achieve smoking cessation (SC), but the drug is metabolized by the cytochrome P450 enzyme system and this might cause interactions with antiretroviral drugs. We present a prospective study of bupropion SC therapy in HIV-positive patients under antiretroviral treatment. A total of 21 patients were studied; 38% of them stopped smoking for more than one year. No clinically significant drug interactions were found. Bupropion SC therapy was effective in HIV-positive patients and did not cause significant clinical interactions with antiretroviral drugs.
authors.affiliation: Unidad de Enfermedades Infecciosas-VIH, Hospital General de Granollers, Barcelona, España. epedrol@fhag.es
authors.forename: Enric
authors.initials: E
authors.lastname: Pedrol-Clotet
authors.forename: Elisabet
authors.initials: E
authors.lastname: Deig-Comerma
authors.forename: Mónica
authors.initials: M
authors.lastname: Ribell-Bachs
authors.forename: Immaculada
authors.initials: I
authors.lastname: Vidal-Castell
authors.forename: Pedro
authors.initials: P
authors.lastname: García-Rodríguez
authors.forename: Anna
authors.initials: A
authors.lastname: Soler
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D016642:Bupropion / Q000627:therapeutic use*; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation
chemical_list: D044966:Anti-Retroviral Agents; D018765:Dopamine Uptake Inhibitors; D016642:Bupropion