Clinicopathologic features of two rare cases of mesenchymal metastatic tumors in the pancreas: review of the literature.
OBJECTIVE
A clinicopathologic presentation of 2 unusual cases of metastatic mesenchymal neoplasms in the pancreas.


METHODS
The first case concerns a 26-year-old man with a history of intracranial mesenchymal chondrosarcoma (since the age of 17), 2 left lung operations, and 3 right thigh operations. Distal pancreatectomy and splenectomy was performed because of suspicious mass in the pancreas. The second case concerns a 66-year-old woman with a history of uterus leiomyosarcoma (10 years ago) with left axillary and right femoral metastases. She underwent distal pancreatectomy and splenectomy because of suspicious mass measuring 4 x 4 cm, in the pancreatic body.


RESULTS
In the first case, the pathological examination revealed a tumor measuring 3.8 x 3.5 cm and histologically compatible with mesenchymal chondrosarcoma, developing in a vessel lumen and invading into the pancreatic parenchyma. In the second case, the pathological examination showed metastatic leiomyosarcoma of high-grade malignancy. The incidence of metastatic pancreatic tumors has been reported to be only 1.6% to 3%. Most of these tumors were of epithelial origin, and the most common sites of the primary lesions were the lung, kidney, and gastrointestinal tract.


CONCLUSIONS
The cases of metastatic uterus leiomyosarcoma and the metastatic intracranial chondrosarcoma are, to our knowledge, the first to be described.
Chatzipantelis
Paschalis
P
Department of Pathology, Areteion University Hospital, The National and Kapodistrian University of Athens, Greece. pchatzipantelis@yahoo.com
Karvouni
Eleni
E
Fragoulidis
Georgios Panagiotis
GP
Voros
Dionysios
D
Pafiti
Agathi
A
D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000368:Aged; D002813:Chondrosarcoma / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008637:Mesenchymoma / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*