Deletions of the endocytic components VPS28 and VPS32 in Candida albicans lead to echinocandin and azole hypersensitivity.
Vps28p and Vps32p act in both the endocytic and the pH signaling pathways in yeasts and are required for Candida albicans virulence. Here, we show that deletions of VPS28 and VPS32 increase the susceptibility of C. albicans to cell wall disruption agents, echinocandin and azole antifungal agents.
Cornet
Muriel
M
Laboratoire de Microbiologie et Génétique Moléculaire, INRA, CBAI, 78850 Thiverval-Grignon, France.
Gaillardin
Claude
C
Richard
Mathias L
ML
D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics; D000077336:Caspofungin; D054714:Echinocandins; D004705:Endocytosis; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000494:pharmacology; D033921:Vesicular Transport Proteins / Q000235:genetics* / Q000378:metabolism
D000935:Antifungal Agents; D001393:Azoles; D054714:Echinocandins; D005656:Fungal Proteins; D055666:Lipopeptides; D008074:Lipoproteins; D009687:Nuclear Proteins; D010456:Peptides, Cyclic; D033921:Vesicular Transport Proteins; D000077336:Caspofungin; D000077551:Micafungin