title: Safety and antioxidant effects of a modest soy protein intervention in hemodialysis patients.
abstract: Antioxidant/anti-inflammatory effects of isoflavone-containing soy protein could partly explain why hemodialysis patients in Japan tend to outlive U.S. hemodialysis patients. However, a safety concern is that dialysis patients do not clear isoflavones well. A low-dose intervention with high isoflavone soy protein (25 g protein, four times a week for 4 weeks) was tested in 17 U.S. hemodialysis patients (eight given soy protein, nine given whey protein as a control). Soy protein intake produced no harmful effects based on a typical battery of blood safety tests. Post-treatment isoflavone levels, though high, were similar to those reported after a single 20-g soy protein intake by dialysis patients. In addition, intake of soy, but not whey, reduced plasma values for oxidized low-density lipoprotein, a risk factor for cardiovascular disease, which is a common mortality cause in hemodialysis patients. Three other measures of oxidant stress and/or inflammation were unchanged by the modest high isoflavone soy protein intervention. In conclusion, in hemodialysis patients, a fairly short, low intake level intervention with high isoflavone soy protein produced no obvious harm, and produced one potentially beneficial effect. This justifies tests of higher-dose, longer interventions with soy protein in hemodialysis patients.
authors.affiliation: Human Nutrition, The Ohio State University, Columbus, Ohio 43210-1295, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Siefker
authors.forename: Robert A
authors.initials: RA
authors.lastname: DiSilvestro
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D005260:Female; D019833:Genistein / Q000097:blood; D006801:Humans; D007529:Isoflavones / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D008894:Milk Proteins; D008517:Phytotherapy; D006435:Renal Dialysis; D030262:Soybean Proteins / Q000008:administration & dosage* / Q000009:adverse effects* / Q000737:chemistry; D000067816:Whey Proteins
chemical_list: D000975:Antioxidants; D007529:Isoflavones; D008077:Lipoproteins, LDL; D008894:Milk Proteins; D030262:Soybean Proteins; D000067816:Whey Proteins; C099252:oxidized low density lipoprotein; C004742:daidzein; D019833:Genistein