[Specified mechanisms of action of preimmunisation with diphtherial anatoxin on myocardial pathology after critical care].
Chronic experiments for 5 weeks made in 41 mongrel adult dogs have shown that prevaccination with diphtheria antitoxin has a negative effect on myocardial and hemodynamic restoration after resustitation. The dogs have arrhythmia, survival of the animals is worse. However, such prevaccination improved survival of the animals due to reduction of reperfusion trauma in animals after hemorrhagic shock in spite of conduction disorders and myocardial ischemia.
Enikeev
D A
DA
Chizhikov
A V
AV
Aleksandrov
M A
MA
D000818:Animals; D001919:Bradycardia / Q000139:chemically induced; D004168:Diphtheria Toxoid / Q000009:adverse effects*; D004285:Dogs; D006329:Heart Conduction System / Q000187:drug effects*; D007114:Immunization / Q000009:adverse effects; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000503:physiopathology
D004168:Diphtheria Toxoid