title: Biological evaluation of chalcones and analogues as hypolipidemic agents.
abstract: In order to evaluate the anti-hyperlipidemic effect of synthetic chalcones and some analogues, nineteen compounds with different substituents in both rings were synthesized and hypolipidemic activities were measured in vivo using Triton WR1339 acute and hypercaloric chronic assays. 4',4-dichlorochalcone, 3',4',4-trichlorochalcone, and 4'-chlorochalcone gave an excellent decrease in serum total cholesterol and triglycerides in the acute assay. These compounds also showed significant anti-lipidemic activity in the chronic assay.
authors.affiliation: Departament of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianopolis, Brazil.
authors.forename: Lorena
authors.initials: L
authors.lastname: Santos
authors.forename: Rozangela
authors.initials: R
authors.lastname: Curi Pedrosa
authors.forename: Rogério
authors.initials: R
authors.lastname: Correa
authors.forename: Valdir
authors.initials: V
authors.lastname: Cechinel Filho
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: Nunes
authors.forename: Rosendo Augusto
authors.initials: RA
authors.lastname: Yunes
mesh_terms: D000818:Animals; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
chemical_list: C515110:4',4-dichlorochalcone; D047188:Chalcones; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D014280:Triglycerides