title: Accelerated apoptosis in SLE neutrophils cultured with anti-dsDNA antibody isolated from SLE patient serum: a pilot study.
abstract: Increased numbers of apoptotic neutrophils are found in SLE, related to disease activity and levels of anti-dsDNA antibody. The mechanism of increased apoptosis is not clear, but anti-dsDNA antibody has been shown to induce apoptosis in neutrophils from normal subjects and in certain cell lines. In this study, polyclonal anti-dsDNA antibody was isolated from the serum of a patient with active SLE, and was shown to substantially accelerate apoptosis in neutrophils from SLE patients as compared with neutrophils from healthy control or rheumatoid arthritis subjects.
authors.affiliation: Department of Rheumatology, Musgrave Park Hospital, Stockman's Lane, Belfast, BT9 7JB, UK. oswald17727@hotmail.com
authors.forename: David J
authors.initials: DJ
authors.lastname: Armstrong
authors.forename: Alistair D
authors.initials: AD
authors.lastname: Crockard
authors.forename: Brian G
authors.initials: BG
authors.lastname: Wisdom
authors.forename: Esme M
authors.initials: EM
authors.lastname: Whitehead
authors.forename: Aubrey L
authors.initials: AL
authors.lastname: Bell
mesh_terms: D000974:Antibodies, Antinuclear / Q000009:adverse effects / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D002478:Cells, Cultured; D004247:DNA / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D010865:Pilot Projects
chemical_list: D000974:Antibodies, Antinuclear; D004247:DNA