The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis.
For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-beta in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-beta level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.
Xiao
Cheng
C
Institute of Basic Theory, China Academy of Traditional Chinese Medicine, Beijing, PR China.
Lu
Cheng
C
Zhao
Linhua
L
Liu
Zhenli
Z
Zhang
Wandong
W
He
Yinghui
Y
Chen
Shilin
S
Tang
Johnny Cheuk-on
JC
Chan
Albert Sun-chi
AS
Lu
Aiping
A
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010581:Peyer's Patches / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000187:drug effects; D029757:Tripterygium
D007166:Immunosuppressive Agents; D010936:Plant Extracts; D016212:Transforming Growth Factor beta