title: Disturbed assembly of human cerebral microtubules in Alzheimer's disease.
abstract: It is shown for the first time that microtubular proteins isolated from the brain of patients with Alzheimer's disease can in vitro polymerize into microtubules with abnormal structure.
authors.affiliation: Laboratory of Neurochemistry, National Center for Mental Health, Russian Academy of Medical Sciences. Ishev@ipac.ac.ru
authors.forename: P N
authors.initials: PN
authors.lastname: Shevtsov
authors.forename: E F
authors.initials: EF
authors.lastname: Shevtsova
authors.forename: G Sh
authors.initials: GSh
authors.lastname: Burbaeva
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure*; D014404:Tubulin / Q000378:metabolism
chemical_list: D008869:Microtubule-Associated Proteins; D014404:Tubulin