Spectroscopic methods in bioinorganic chemistry: blue to green to red copper sites.
A wide variety of spectroscopic methods are now available that provide complimentary insights into the electronic structures of transition-metal complexes. Combined with calculations, these define key bonding interactions, enable the evaluation of reaction coordinates, and determine the origins of unique spectroscopic features/electronic structures that can activate metal centers for catalysis. This presentation will summarize the contributions of a range of spectroscopic methods combined with calculations in elucidating the electronic structure of an active site using the blue copper site as an example. The contribution of electronic structure to electron-transfer reactivity will be considered in terms of anisotropic covalency, electron-transfer pathways, reorganization energy, and protein contributions to the geometric and electronic structures of blue-copper-related active sites.
Solomon
Edward I
EI
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. edward.solomon@stanford.edu
D001665:Binding Sites; D015393:Chemistry, Bioinorganic / Q000379:methods*; D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D008958:Models, Molecular; D010970:Plastocyanin / Q000737:chemistry*; D011789:Quantum Theory; D018629:Spectrometry, Mass, Secondary Ion; D013059:Spectrum Analysis, Raman
D003300:Copper; D010970:Plastocyanin