title: Factors associated with failure in managing pelvic sepsis after ileal pouch-anal anastomosis (IPAA)--a multivariate analysis.
abstract: BACKGROUND
  Pelvic sepsis is known to cause a detrimental outcome after ileal pouch-anal anastomosis (IPAA). The aim of this study was to examine potential factors associated with failure in managing pelvic sepsis after IPAA.
  
  
  METHODS
  We performed univariate and multivariate logistic regression analysis on 2518 IPAA patients between 1983 and 2005. Failure was defined as pouch failure, the need for a permanent ileostomy, or mortality as a result of sepsis. There were 157 patients (6.2%) with pelvic sepsis after IPAA. These involved anastomotic leak 34% (54/157) and fistula 25% (40/157). There were 5 mortalities related to sepsis. Mean age at surgery was 38.1 +/- 14.4 years and mean follow-up was 5.5 +/- 4.7 years.
  
  
  RESULTS
  Pouches were saved in 75.8% patients. Univariate analysis identified early sepsis (P = .040), preoperative steroid use (P = .007), and need for percutaneous drainage (P = .004) as significant factors associated with treatment success. Factors associated with failure were hypertension (P = .026), hand-sewn anastomosis (P = .038), associated fistula (P = .0003), need for transanal drainage (P = .0002), need for laparotomy to control septic complications (P < .0001), delayed ileostomy closure (P = .0003), and need for a new diverting ileostomy (P < .0001). By using multivariate analysis with selected covariates, significant factors associated with failure were associated fistula (P = .0013), need for transanal drainage (P = .003), delayed ileostomy closure (P = .022), need for a new ileostomy diversion (P = .004), and hypertension (P = .039). We developed a predictive scoring system for failure to use in management plans and decision-making for the treatment of septic complications of IPAA.
  
  
  CONCLUSIONS
  Pelvic sepsis after IPAA has a significant impact on pouch failure. This predictive model for failure may play an important role in providing risk estimates for successful outcomes.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Ismail
authors.initials: I
authors.lastname: Sagap
authors.forename: Feza H
authors.initials: FH
authors.lastname: Remzi
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Hammel
authors.forename: Victor W
authors.initials: VW
authors.lastname: Fazio
mesh_terms: D018784:Abdominal Abscess / Q000209:etiology / Q000401:mortality / Q000628:therapy; D000328:Adult; D002908:Chronic Disease; D039021:Colonic Pouches / Q000009:adverse effects*; D015897:Comorbidity; D016154:Digestive System Fistula / Q000209:etiology / Q000401:mortality / Q000628:therapy; D004322:Drainage; D005260:Female; D006801:Humans; D007081:Ileostomy; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D034161:Pelvic Infection / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D016737:Proctocolectomy, Restorative / Q000401:mortality*; D012372:ROC Curve; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D012720:Severity of Illness Index; D017211:Treatment Failure