title: Postnatal - physiological research of the bronchial receptor system development on the isolated preparation of the human trachea in vitro.
abstract: Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children. Monitored was the response on: acetylcholine, dopamine, histamine and serotonin in different molar concentrations 10(-4), 10(-3), 10(-2), 10 mol/dm(-3), micromol/dm(-3)). Research was done on tonus of tracheal smooth muscles of 23 tracheal preparations taken by autopsy after death from different factors. Based on pharmacological-physiological research on the preparations of human isolated trachea it was find out that: acetylcholine stimulation effect is significant (p>0,01) in 38-41 weeks of pregnancy comparing with that in 30-37 weeks of pregnancy (p>0,01), while dopamine stimulation effect is significant (p>0,05) in 30-37 pregnancy weeks comparing with the effect of acetylcholine and dopamine on the still-born infants of the same pregnancy period (p<0,01). Histaminic receptors were developed during intrauterine life after 38 weeks of pregnancy (p>0,025). Serotonin has caused contraction of the bronchial smooth muscles after 30 pregnancy weeks, but response was not significant (p<0,01). This suggests that cholinergic and adrenergic system of the airways in alive newborn infants develops in parallel intrauterine, contrary to other systems which develop in certain extrauterine life phases.
authors.affiliation: Bosnalijek-Pharmaceutical Company - Sarajevo, Bosnia and Herzegovina.
authors.forename: Aziz
authors.initials: A
authors.lastname: Sukalo
authors.forename: Hilmi
authors.initials: H
authors.lastname: Islami
authors.forename: Ragib
authors.initials: R
authors.lastname: Shabani
authors.forename: Hilmi
authors.initials: H
authors.lastname: Dauti
authors.forename: Skender
authors.initials: S
authors.lastname: Kutllovci
authors.forename: Bashkim
authors.initials: B
authors.lastname: Kastrati
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D001980:Bronchi / Q000254:growth & development / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006632:Histamine / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009130:Muscle, Smooth / Q000378:metabolism*; D011247:Pregnancy; D017982:Receptors, Biogenic Amine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D014132:Trachea / Q000254:growth & development* / Q000378:metabolism*
chemical_list: D017982:Receptors, Biogenic Amine; D012701:Serotonin; D006632:Histamine; D000109:Acetylcholine; D004298:Dopamine