Differential signaling networks induced by mild and lethal hemorrhagic fever virus infections.
The family Arenaviridae includes several National Institutes of Allergy and Infections Diseases category A select agents which cause hemorrhagic fever. There are few vaccines available, and treatment is limited to ribavirin, which varies in efficacy. Development of new antiviral compounds has been hindered by a lack of understanding of the molecular basis of pathogenesis. We used two variants of Pichinde virus, one attenuated and one virulent in the guinea pig model, to delineate the host determinants which lead to either viral clearance or lethal disease. By analyzing protein level changes using pathway analysis, we have identified key intermediates which may be targets for therapeutic intervention.
Bowick
Gavin C
GC
University of Texas Medical Branch, 201 University Blvd., Galveston, TX 77555, USA.
Fennewald
Susan M
SM
Elsom
Barry L
BL
Aronson
Judith F
JF
Luxon
Bruce A
BA
Gorenstein
David G
DG
Herzog
Norbert K
NK
D000818:Animals; D001117:Arenaviridae Infections / Q000378:metabolism*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006168:Guinea Pigs; D015151:Immunoblotting; D008264:Macrophages / Q000737:chemistry; D018052:Pichinde virus / Q000235:genetics / Q000472:pathogenicity*; D020543:Proteome / Q000032:analysis*
D020543:Proteome