title: Skin regeneration for children with burn scar contracture using autologous cultured dermal substitutes and superthin auto-skin grafts: preliminary clinical study.
abstract: We have evaluated a novel treatment of burn scar contracture in children. This method involves the application of an autologous cultured dermal substitute (CDS), followed by a graft of superthin split-thickness skin. In the first operation, the autologous CDS was applied to the skin defect that had occurred after releasing the scar contracture. In the second operation, a superthin thickness skin graft (4 approximately 6/1000 inches) was applied 5 approximately 12 days after the first operation. The autologous CDS was applied to 10 sites of 5 children. On 8 sites, the skin grafts were contracted to some extent at an early stage. However, these skin grafts were stretched gradually to a range from 60% to 100% of an original size. At 2 sites, the skin grafts had stretched from 110% to 130% of the original size. This strategy may be useful for the treatment of burn scar contracture in children.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Osaka Medical College, Takatsuki, Japan. pla019@poh.osaka-med.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujimori
authors.forename: Koichi
authors.initials: K
authors.lastname: Ueda
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fumimoto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kubo
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Kuroyanagi
mesh_terms: D002056:Burns / Q000150:complications / Q000601:surgery*; D018929:Cell Culture Techniques; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000209:etiology / Q000601:surgery*; D003094:Collagen; D003286:Contracture / Q000209:etiology / Q000601:surgery*; D005260:Female; D005347:Fibroblasts / Q000637:transplantation; D006801:Humans; D006820:Hyaluronic Acid; D007223:Infant; D008297:Male; D011183:Postoperative Complications; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: D006820:Hyaluronic Acid; D003094:Collagen