Effect of enalapril injected in the early period of postnatal ontogeny on structure of adrenal glands in mature hypertensive NISAG rats.
Blood pressure in 6-month hypertensive NISAG rats daily treated with enalapril in the early postnatal period was lower than in control rats. Enalapril produced significant morphological alterations only in the zona glomerulosa of the adrenal cortex. The volumes of this area and the corresponding endocrine cells were lower than in the control. Enalapril produced a delayed modifying effect on the structure of the adrenal zona glomerulosa by moderating hyperplasic alterations, which are characteristic of intact mature NISAG rats.
Buzueva
I I
II
State Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. i.i.buzueva@iph.ma.nsc.ru
D000311:Adrenal Glands / Q000187:drug effects* / Q000473:pathology*; D000367:Age Factors; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004656:Enalapril / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D015384:Zona Glomerulosa / Q000187:drug effects / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004656:Enalapril