title: Horizons in prosthesis development for the restoration of limb function.
abstract: The focus of our research program is the restoration of limb function through a biohybrid approach. We consider the limb conceptually as a biohybrid organ consisting of biological tissue, endoprostheses (including neural devices and joint replacements), and exoprostheses. The biohybrid limb maximizes biological function and functional articulations with optimized human-prosthesis interfaces. Our long-term goals are to create biomimetic prostheses, optimized control systems for prostheses, and optimized human-prosthesis interfaces using both limb lengthening and osseointegration techniques.
authors.affiliation: Department of Orthopaedics, Brown University, Providence, RI, USA.
authors.forename: Roy K
authors.initials: RK
authors.lastname: Aaron
authors.forename: Hugh M
authors.initials: HM
authors.lastname: Herr
authors.forename: Deborah McK
authors.initials: DM
authors.lastname: Ciombor
authors.forename: Leigh R
authors.initials: LR
authors.lastname: Hochberg
authors.forename: John P
authors.initials: JP
authors.lastname: Donoghue
authors.forename: Clyde L
authors.initials: CL
authors.lastname: Briant
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Morgan
authors.forename: Michael G
authors.initials: MG
authors.lastname: Ehrlich
mesh_terms: D000671:Amputation, Surgical; D000674:Amputees / Q000534:rehabilitation*; D001186:Artificial Limbs / Q000639:trends*; D006801:Humans; D007866:Leg / Q000502:physiology*; D007869:Leg Injuries / Q000503:physiopathology / Q000601:surgery*; D011474:Prosthesis Design / Q000639:trends; D020127:Recovery of Function