title: H pylori infection among 1000 southern Iranian dyspeptic patients.
abstract: OBJECTIVE
  To describe the frequency of H pylori infection among 1000 southern Iranian dyspeptic patients.
  
  
  METHODS
  A prospective study was performed in a referral hospital in south of Iran from 1999 to 2005. One thousand dyspeptic patients (518 males, mean +/- SD age of 49.12 +/- 12.82 years) consecutively underwent upper gastrointestinal endoscopy. Multiple gastric antral biopsy samples were taken from all patients for rapid urease test and histopathologic examination (96.9% satisfactory samples). Patients were considered H pylori-infected if one or both tests were positive.
  
  
  RESULTS
  Six hundred and seventy-one patients (67.1%, 95% confidence interval [CI]: 64.2%-70.0%) were H pylori-infected. H pylori positivity was significantly more frequent in patients with peptic ulcer disease (PUD) than in those with non-ulcer dyspepsia (P < 0.001). Male-to-female ratio for duodenal and gastric ulcers was 2.7:1 and 1.5:1, respectively. Moreover, the duodenal-to-gastric ulcer ratio was 1.95:1. The frequency of H pylori infection among those with endoscopic diagnosis of gastritis, duodenal ulcer, gastric ulcer, and normal mucosa was 70.1% (398/568), 86.2% (150/174), 71.9% (64/89), and 33.5% (54/161), respectively. H pylori infection, male sex, and older age were independently associated with PUD in multivariate analysis. H pylori positivity was associated with chronic gastritis, and chronic active gastritis with odds ratios of 34.21 (95% CI: 12.19%-96.03%) and 81.21 (95% CI: 28.85%-228.55%), respectively.
  
  
  CONCLUSIONS
  H pylori and PUD are highly frequent in dyspeptic patients from south of Iran. H pylori is a cardinal risk factor for chronic active or inactive gastritis.
authors.affiliation: Department of Gastroenterology, Hormozgan University of Medical Sciences, Bandarabbas, Artesh University of Medical Sciences, Tehran, Iran.
authors.forename: Mahmood Reza
authors.initials: MR
authors.lastname: Hashemi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rahnavardi
authors.forename: Bavand
authors.initials: B
authors.lastname: Bikdeli
authors.forename: Mohsen
authors.initials: M
authors.lastname: Dehghani Zahedani
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004415:Dyspepsia / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005756:Gastritis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D015995:Prevalence; D011446:Prospective Studies; D011706:Pyloric Antrum / Q000382:microbiology / Q000473:pathology; D012737:Sex Factors