[An analysis of the relationship between HBV DNA and HBeAg expression and mortality in 799 severe hepatitis patients].
OBJECTIVE
To evaluate the relationship between mortality and HBVDNA and HBeAg expression of severe hepatitis B patients.


METHODS
The mortality rates of different types of severe hepatitis patients in our hospital during the last five years were analysed. HBV DNA was detected using the fluorescence quantitative PCR method and the HBeAg expression of severe hepatitis B was studied using a microparticle method.


RESULTS
(1) Hepatitis B morbidity was 83.5% in each type of severe hepatitis, and severe chronic hepatitis B morbidity was 96.77% in each type of severe chronic hepatitis. (2) The mortality rate of those with HBV DNA more than 1 x 10(5) copies/ml was 53.25% and the mortality of those with HBV DNA less than 1 x 10(5) copies/ml was 34.50% (P less than 0.01). The HBeAg expression had no influence on the death rate. (3) The death rate descended to 30.38% from 54.64% (HBV DNA more than 1 x 10(5) copies/ml) when treated with Lamivudine (P less than 0.01).


CONCLUSIONS
In severe hepatitis the quantity of virus carried in the patient is one of the key factors of mortality; antivirus treatment can lower mortality.
Wang
Rong-bing
RB
Department of Infectious Diseases, Beijing Ditan Hospital, Beijing 100011, China.
Zhou
Gui-qin
GQ
Jiang
Yu-yong
YY
Sun
Feng-xia
FX
Wu
Yun-zhong
YZ
Sun
Jing-yuan
JY
Meng
Pei-pei
PP
Niu
Si-meng
SM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004279:DNA, Viral; D005260:Female; D006514:Hepatitis B Surface Antigens; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D055815:Young Adult
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens