Mechanisms of formation of micronuclei in somatic cells of tailless amphibians normally and under the effect of N-nitroso-N-methylcarbamide.
We studied the relationship between mitotic regimen and incidence of micronuclei in liver and bone marrow cells of tailless amphibians under the effect of genotoxic carcinogen N-nitroso-N-methylcarbamide. Micronuclei appeared in amphibian somatic cells normally and after mutagenic exposure as a result of abnormal mitosis and of "interphase chromatin diminution". This latter variant was most incident in lymphoid cells, presenting as "caudate nuclei", which should be taken into consideration when interpreting findings of micronucleus analysis.
Manskikh
V N
VN
Department of Biology and Genetics, Siberian State Medical University, Tomsk.
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000648:ultrastructure; D002023:Bufo bufo; D022781:Hepatocytes / Q000187:drug effects / Q000648:ultrastructure; D008770:Methylnitrosourea / Q000633:toxicity*; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D015162:Micronucleus Tests; D008938:Mitosis; D009153:Mutagens / Q000633:toxicity*; D011898:Ranidae
D009153:Mutagens; D008770:Methylnitrosourea