Synthesis of some novel sulfur containing triazolothienopyrimidines and biscompounds as possible antitumor and radioprotective agents.
The syntheses of novel 1,2,4-triazolothienopyrimidine derivatives (4a,b), thiourea derivatives (5-8) and biscompounds having a thieno[2,3-d]pyrimidine nucleus (13-16) utilizing the 2-isothiocyanato derivatives 2a,b are reported. The structures of these compounds were confirmed by microanalysis, IR, 1H-NMR and mass spectrometry. Preliminary biological studies of some synthesized compounds showed promising antitumor and radioprotective activities.
Heiba
Helmy I
HI
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt.
Ragab
Fatma A
FA
Noaman
Eman
E
Ghorab
Moustafa M
MM
Galal
Marwa
M
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D005260:Female; D005720:Gamma Rays; D005978:Glutathione / Q000097:blood; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D009368:Neoplasm Transplantation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood
D000970:Antineoplastic Agents; D000975:Antioxidants; D007202:Indicators and Reagents; D011743:Pyrimidines; D011837:Radiation-Protective Agents; D013457:Sulfur Compounds; D013482:Superoxide Dismutase; D005978:Glutathione