title: Four primary malignancies successively occurred in a BRCA2 mutation carrier: a case report.
abstract: Carriers of BRCA2 germline mutation have a significantly increased lifetime risk of breast and ovarian cancer compared to non carriers. Several other carcinomas seem to be associated with BRCA2 mutations: pancreas, prostate, larynx, gallbladder, bile duct cancer, and malignant melanoma. We described a case of a 67-year-old BRCA2 mutation carrier of Caucasian, non-Jewish, ethnic origin who successively developed 4 primary malignancies in 30 months: breast ductal carcinoma, chronic lymphatic leukemia, ovarian serous papillary carcinoma, and endocervical adenocarcinoma. This is the first case of 4 primary malignancies in a BRCA mutation carrier, also occurred in such a short observation period. Chronic lymphatic leukemia and endocervical adenocarcinoma have not been yet associated to BRCA2 germline mutation.
authors.affiliation: Cattedra di Ginecologia ed Ostetricia, Università di Udine, Udine, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fruscalzo
authors.forename: G
authors.initials: G
authors.lastname: Damante
authors.forename: A
authors.initials: A
authors.lastname: Calcagno
authors.forename: C
authors.initials: C
authors.lastname: Di Loreto
authors.forename: D
authors.initials: D
authors.lastname: Marchesoni
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000628:therapy; D000328:Adult; D000368:Aged; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000473:pathology / Q000628:therapy; D018283:Cystadenocarcinoma, Papillary / Q000235:genetics / Q000473:pathology / Q000628:therapy; D018284:Cystadenocarcinoma, Serous / Q000235:genetics / Q000473:pathology / Q000628:therapy; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D010375:Pedigree; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy
chemical_list: D024682:BRCA2 Protein