Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone regeneration in a patient with compartment syndrome.
A 28-year-old man developed compartment syndrome in the right lower leg after fracture of the tibia and fibula. Despite fasciotomy, many arteries collapsed and union of the tibial and fibula fractures did not occur. Autologous bone marrow mononuclear cell (BMMNC) implantation for therapeutic angiogenesis and subsequent bone regeneration was performed and 4 weeks later, angiography showed a marked increase in collateral vessels surrounding the tibial fracture, and union was completed 6 months later. BMMNC implantation therapy might provide therapeutic angiogenesis and osteogensis in patients with compartment syndrome.
Umemura
Takashi
T
Department of Cardiovascular Physiology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Hiroshima, Japan.
Nishioka
Kenji
K
Igarashi
Akira
A
Kato
Yukio
Y
Ochi
Mitsuo
M
Chayama
Kazuaki
K
Yoshizumi
Masao
M
Higashi
Yukihito
Y
D016026:Bone Marrow Transplantation; D001861:Bone Regeneration; D003097:Collateral Circulation; D003161:Compartment Syndromes / Q000628:therapy*; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D007866:Leg; D008297:Male; D018919:Neovascularization, Physiologic; D014182:Transplantation, Autologous