[The role of SM22 alpha in cytoskeleton organization and vascular remodeling].
Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a key role in vascular remodeling diseases, such as atherosclerosis, hypertension and restenosis. Recent researches have focused on the expression regulation of VSMC-specific marker genes and cytoskeleton organization in association with phenotypic modulation of VSMCs. Smooth muscle 22 alpha (SM22 alpha) is a novel differentiated VSMC marker, which is characterized by its smooth muscle tissue-specific and VSMC phenotype-specific expression pattern, and serves as an actin-association protein to participate in VSMC cytoskeleton organization and vascular remodeling. This article reviews recent advances in the characterization of SM22 alpha structure and its mechanism in VSMC cytoskeleton organization and vascular remodeling.
Shi
Jian-Hong
JH
Institute of Basic Medicine, Hebei Medical University, Hebei Laboratory of Medical Biotechnology, Shijiazhuang, China.
Wen
Jin-Kun
JK
Han
Mei
M
D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins / Q000737:chemistry / Q000502:physiology*; D009124:Muscle Proteins / Q000737:chemistry / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D010641:Phenotype
D008840:Microfilament Proteins; D009124:Muscle Proteins; C051615:transgelin