Capsular antigens of bacteria. Capsular antigens as the basis of vaccines against pathogenic bacteria.
The role of bacterial capsular antigens represented in capsular polysaccharides and exoglycans in pathogenicity and virulence of bacteria is discussed in this review. Using capsular antigens for vaccines against severe diseases caused by capsular microorganisms is considered in detail. The use of conjugates of capsular polysaccharides and their fragments with proteins and peptides for vaccine as well as using liposomes as adjuvants for the capsular antigens are described. Data concerning structural elucidation of bacterial capsular antigens are given in the first part of this review.
Ovodov
Yu S
YS
Institute of Physiology, Komi Science Center, The Urals Branch of the Russian Academy of Sciences, Syktyvkar 167982, Russia. ovoys@physiol.komisc.ru
D000276:Adjuvants, Immunologic; D000328:Adult; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D016667:Bacterial Capsules / Q000276:immunology*; D001424:Bacterial Infections / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002648:Child; D006192:Haemophilus Infections / Q000517:prevention & control; D006193:Haemophilus influenzae / Q000472:pathogenicity; D006801:Humans; D008081:Liposomes; D008585:Meningitis, Meningococcal / Q000517:prevention & control; D011008:Pneumococcal Infections / Q000517:prevention & control; D013203:Staphylococcal Infections / Q000517:prevention & control; D013290:Streptococcal Infections / Q000517:prevention & control; D013292:Streptococcus agalactiae / Q000472:pathogenicity; D014774:Virulence
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D008081:Liposomes