title: Unusual presentation of large B cell lymphoma: a case report and review of literature.
abstract: Diffuse large B cell lymphoma (DLBCL) is the largest subtype of non-Hodgkin's lymphomas (NHLs) and is characterized by relatively frequent extranodal presentation. In these cases, the most common extranodal localizations are stomach, CNS, bone, testis and liver. Simultaneous detection of multiple extranodal involvement at presentation is quite uncommon, with the majority of these cases characterized by gastric or intestinal disease localization. Retrospective analysis concerning multifocal extranodal NHLs never pointed out disease features such as those described here. We report a patient with an unusual presentation of DLBCL, characterized by adrenal and renal involvement, associated with symptoms and signs of the cold agglutinin disease and a hypercoagulable state. Subsequently, computed tomography (CT) and fluorodeoxyglucose-positron emission tomography (FDG-PET) scanning disclosed a rapidly extensive spread to nodes and bones. Cytofluorimetric analysis of a renal specimen showed medium-to-large lympho-monocytoid elements positive for CD20 with monoclonal expression of immunoglobulin kappa light chain. Histopathological examination confirmed a renal CD20 positive DLBCL localization.
authors.affiliation: First Division of Internal Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy. lairagh@tin.it
authors.forename: L
authors.initials: L
authors.lastname: Airaghi
authors.forename: I
authors.initials: I
authors.lastname: Greco
authors.forename: M
authors.initials: M
authors.lastname: Carrabba
authors.forename: M
authors.initials: M
authors.lastname: Barcella
authors.forename: I M
authors.initials: IM
authors.lastname: Baldini
authors.forename: P
authors.initials: P
authors.lastname: Bonara
authors.forename: M
authors.initials: M
authors.lastname: Goldaniga
authors.forename: L
authors.initials: L
authors.lastname: Baldini
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000473:pathology*; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology; D001707:Biopsy, Needle; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D010292:Paresthesia / Q000209:etiology*; D049268:Positron-Emission Tomography; D019851:Thrombophilia / Q000209:etiology; D014057:Tomography, X-Ray Computed