title: Effect of nucleotide intake and nutritional recovery on insulin-like growth factor I and other hormonal biomarkers in severely malnourished children.
abstract: The objective of the present study is to demonstrate the effect of nucleotide intake and intensive nutritional support on the concentration of insulin-like growth factor I (IGF-I) and other hormonal biomarkers in severely malnourished children. Twenty-six severely malnourished children < 48 months of age received formula without lactose via enteral feeding for 2 weeks and ad libitum for an additional 2 weeks. Anthropometrical measurements were performed and serum concentrations of IGF-I, insulin-like growth factor binding protein-3 (IGFBP-3), leptin, soluble leptin receptor (sOB-R), as well as the estimated molar excess of sOB-R over leptin were obtained. Two groups were formed. One group received formula with nucleotides (NT+; n 13) and the other without nucleotides (NT-; n 13). A control group was included (n 13). Parametric and non-parametric tests as well as ANOVA models were used. Nutritional recovery, nucleotides intake, type of malnutrition, age and the interaction between gender and malnutrition influenced the concentration of IGF-I (P < 0.001). Nutritional recovery, nucleotides intake, gender and type of malnutrition had an effect on IGFBP-3 (P < 0.001). Nutritional recovery had a significant effect on serum leptin (P = 0.001). Age and nutritional recovery had an effect on sOB-R (P < 0.001); all variables included affected the molar excess of sOB-R over leptin (P < 0.001). In conclusion, nucleotide intake and nutritional recovery had a notable effect on IGF-I, IGFBP-3 and other hormonal biomarkers. This outcome could stimulate the catch-up growth of severely malnourished infants and toddlers during the nutritional recovery period.
authors.affiliation: Institute of Human Nutrition, University Center of Health Sciences, University of Guadalajara, Unit of Infant Nutrition Studies, Civil Hospital of Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico. inhu@cucs.udg.mx
authors.forename: Edgar
authors.initials: E
authors.lastname: Vásquez-Garibay
authors.forename: Katja
authors.initials: K
authors.lastname: Stein
authors.forename: Juergen
authors.initials: J
authors.lastname: Kratzsch
authors.forename: Enrique
authors.initials: E
authors.lastname: Romero-Velarde
authors.forename: Gerhard
authors.initials: G
authors.lastname: Jahreis
mesh_terms: D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D004750:Enteral Nutrition / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D007227:Infant Nutritional Physiological Phenomena; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D008297:Male; D044342:Malnutrition / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D009711:Nucleotides / Q000008:administration & dosage*
chemical_list: D015415:Biomarkers; D018972:Insulin-Like Growth Factor Binding Protein 3; D020738:Leptin; D009711:Nucleotides; D007334:Insulin-Like Growth Factor I