title: Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines.
abstract: A novel diastereoselective synthesis of substituted pyrrolidines has been developed. Asymmetric multicomponent reactions of optically active phenyldihydrofuran, N-tosyl imino ester, and silane reagents in a one-pot operation afforded highly substituted pyrrolidine derivatives diastereoselectively. The reaction is quite efficient and constructed up to three stereogenic centers in a single operation.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA. akghosh@purdue.edu
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Sarang
authors.initials: S
authors.lastname: Kulkarni
authors.forename: Chun-Xiao
authors.initials: CX
authors.lastname: Xu
authors.forename: Phillip E
authors.initials: PE
authors.lastname: Fanwick
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011392:Proline / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011759:Pyrrolidines; D011392:Proline