The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats.
We investigated the effect of caffeic acid phenethyl ester in rat ileum injury induced by chronic biliary obstruction. Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, common bile duct ligation (n = 7); and Group 3, common bile duct ligation plus caffeic acid phenethyl ester (n = 7). In the caffeic acid phenethyl ester-treated rats, ileum tissue levels of malondialdehyde and myeloperoxidase were significantly lower than those of the bile duct-ligated rats (P < 0.001). The levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-1alpha in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). The present study demonstrates that intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative stress. This effect may be useful in the preservation of intestinal damage in cholestasis.
Ara
Cengiz
C
Department of General Surgery, Inonu University School of Medicine, 44069 Malatya, Turkey. cara@inonu.edu.tr
Esrefoglu
Mukaddes
M
Polat
Alattin
A
Isik
Burak
B
Aladag
Murat
M
Gul
Mehmet
M
Ay
Selma
S
Tekerleklioglu
M Sait
MS
Yilmaz
Sezai
S
D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D002109:Caffeic Acids / Q000494:pharmacology*; D001651:Cholestasis, Extrahepatic / Q000382:microbiology / Q000473:pathology*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D007082:Ileum / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D008643:Mesentery; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology
D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol