Reactivity of (1-->3)-beta-d-glucan assay with commonly used intravenous antimicrobials.
Forty-four intravenous antimicrobials were tested for the presence of (1-->3)-beta-d-glucan (BG). Colistin, ertapenem, cefazolin, trimethoprim-sulfamethoxazole, cefotaxime, cefepime, and ampicillin-sulbactam tested positive for BG at reconstituted-vial concentrations but not when diluted to usual maximum plasma concentrations. False-positive BG assays may occur when some antimicrobials are administered; however, this needs to be confirmed.
Marty
Francisco M
FM
Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA 02115, USA. fmarty@partners.org
Lowry
Colleen M
CM
Lempitski
Steven J
SJ
Kubiak
David W
DW
Finkelman
Malcolm A
MA
Baden
Lindsey R
LR
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D005189:False Positive Reactions; D006801:Humans; D007275:Injections, Intravenous; D009181:Mycoses / Q000175:diagnosis*; D011509:Proteoglycans; D011933:Reagent Kits, Diagnostic; D047071:beta-Glucans / Q000032:analysis* / Q000097:blood*
D000900:Anti-Bacterial Agents; D011509:Proteoglycans; D011933:Reagent Kits, Diagnostic; D047071:beta-Glucans; C010770:polysaccharide-K