Cardiac isoform of alpha 2 macroglobulin, an early diagnostic marker for cardiac manifestations in AIDS patients.
This study investigated the possible role of the cardiac isoform of alpha 2-macroglobulin (CA2M) as an early diagnostic marker for HIV-associated cardiovascular manifestations. A total of 349 samples were analysed by Western blot and quantified by sandwich enzyme-linked immunosorbent assay. The levels of CA2M present in sera of HIV-associated cardiac diseases were significantly higher than those of HIV without cardiac involvement and healthy sera. CA2M may act as a novel diagnostic marker to identify cardiac manifestations in HIV/AIDS patients.
Ramasamy
Subbiah
S
Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamilnadu, India.
Omnath
Reghunath
R
Rathinavel
Andiappan
A
Kannan
Perumal
P
Dhandapany
Perundurai S
PS
Annapoorani
Ponnambalam
P
Balakumar
Pitchai
P
Singh
Manjeet
M
Ganesh
Rajagopalan
R
Selvam
Govindan Sadasivam
GS
D015415:Biomarkers / Q000097:blood; D015153:Blotting, Western; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D006331:Heart Diseases / Q000175:diagnosis* / Q000821:virology*; D006801:Humans; D020033:Protein Isoforms / Q000032:analysis*; D012680:Sensitivity and Specificity; D000511:alpha-Macroglobulins / Q000032:analysis*
D015415:Biomarkers; D020033:Protein Isoforms; D000511:alpha-Macroglobulins