Przewalskin A: A new C23 terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii maxim.
Przewalskin A (1), a novel C23 terpenoid with a 6/6/7 carbon ring skeleton, was isolated from Salvia przewalskii. Its structure was determined by comprehensive 1D NMR, 2D NMR, and MS spectroscopic analysis and subsequently confirmed by a single-crystal X-ray diffraction study of its PDC oxidation derivative (2). Compounds 1 and 2 showed modest anti-HIV-1 activity with EC50 = 41 and 89 microg/mL, respectively.
Xu
Gang
G
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PRC.
Hou
Ai-Jun
AJ
Wang
Rui-Rui
RR
Liang
Guang-Yu
GY
Zheng
Yong-Tang
YT
Liu
Ze-Yuan
ZY
Li
Xiao-Li
XL
Zhao
Yu
Y
Huang
Sheng-Xiong
SX
Peng
Li-Yan
LY
Zhao
Qin-Shi
QS
D002244:Carbon / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D027544:Salvia / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry*
D003512:Cyclohexanones; D004224:Diterpenes; D013729:Terpenes; C520938:przewalskin A; D002244:Carbon