title: [Topical tacrolimus and resistant skin lesions of dermatomyositis].
abstract: BACKGROUND
  Dermatomyositis is an inflammatory myopathy associated with an increased risk of mortality due to visceral involvement. Cutaneous involvement has no vital impact but considerably affects the quality of life of the patients and can resist to classical therapies. More treatment options are needed. We report here the case of three patients presenting resistant cutaneous lesions of dermatomyositis successfully treated with topical tacrolimus.
  
  
  METHODS
  A dramatic cure of the lesions of the face and the hands and a moderate response of other areas were observed without adverse effects.
  
  
  CONCLUSIONS
  Tacrolimus is an immunosuppressive agent and topical tacrolimus is used for the treatment of atopic dermatitis and has been occasionally used to treat skin involvement of some systemic inflammatory diseases. Topical tacrolimus seems to be a good therapeutic alternative for resistant skin lesions of dermatomyositis. It could also be proposed as a first intention therapy because of its good tolerance.
authors.affiliation: Service de dermatologie, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France.
authors.forename: I
authors.initials: I
authors.lastname: Peyrot
authors.forename: A
authors.initials: A
authors.lastname: Sparsa
authors.forename: V
authors.initials: V
authors.lastname: Loustaud-Ratti
authors.forename: E
authors.initials: E
authors.lastname: Liozon
authors.forename: E
authors.initials: E
authors.lastname: Vidal
authors.forename: J-M
authors.initials: JM
authors.lastname: Bonnetblanc
authors.forename: C
authors.initials: C
authors.lastname: Bedane
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D003882:Dermatomyositis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus