title: Regulation of alpha-chymotrypsin activity on the surface of substrate-functionalized gold nanoparticles.
abstract: A gold nanoparticle functionalized with substrates for alpha-chymotrypsin was fabricated to afford an enzyme modulator that exhibited enzyme-specific activation coupled with general inhibition of other proteases.
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
authors.forename: Chang-Cheng
authors.initials: CC
authors.lastname: You
authors.forename: Rochelle R
authors.initials: RR
authors.lastname: Arvizo
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006046:Gold; D053758:Nanoparticles; D009842:Oligopeptides / Q000494:pharmacology
chemical_list: D009842:Oligopeptides; C015516:succinyl-trialanine-4-nitroanilide; D006046:Gold; D002918:Chymotrypsin; C117608:alpha-chymotrypsin