title: Transient hypolocomotion in rats repeatedly exposed to phencyclidine: an appraisal of motor function and motivation.
abstract: Spontaneous locomotion in rats is reduced about 20 h following phencyclidine (PCP) exposure. Our primary purpose was to test if locomotor irregularities would outlast drug withdrawal and be modulated by a periodic auditory stimulation during or after repeated injections. To circumscribe plausible interpretations, motor coordination and motivation were assessed as well. 10 mg/kg of PCP decreased spontaneous locomotion during the injection period whether or not a sound was presented. Those effects did not persist after a 7-day washout. Motor coordination and motivation to perform a variety of goal-driven conducts in the presence or absence of reinforcement were all unaffected by PCP treatment. The generalized hypolocomotor effects induced by PCP likely resulted from an inability to self-generate behaviors. These deficiencies were apparent in contexts where response production was not clearly specified nor supported, regardless of reward contingency.
authors.affiliation: Ecole de psychologie, Université Laval, Québec, Canada.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Audet
authors.forename: Sonia
authors.initials: S
authors.lastname: Goulet
authors.forename: François Y
authors.initials: FY
authors.lastname: Doré
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003864:Depression, Chemical; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D006213:Hallucinogens / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D009042:Motivation; D009043:Motor Activity / Q000187:drug effects*; D010622:Phencyclidine / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D018691:Excitatory Amino Acid Antagonists; D006213:Hallucinogens; D010622:Phencyclidine