title: [Study on the genotyping and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau].
abstract: OBJECTIVE
  To study the distribution of genomovars and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau.
  
  
  METHODS
  Primer pairs targeting the twenty-two different regions(DFRs) were designed for detecting the presence or deletion of each DFR in 297 strains isolated from the Qinghai-Tibet Plateau.
  
  
  RESULTS
  9 genomovars, i. e. Genomovar 1, 5, 6, 7, 8, 10, 11, new type and Ype-ancestor were identified in the Marmota himalayana plague focus of the Qinghai-Tibet Plateau. Among these genomovars, genomovar 5,8 and 10 were dominant types. The total rate of the three genomovars was 80.6% (204/253) and the genomovars in different regions were different. All of 44 strains of Y. pestis in the Microtus fuscus plague focus of the Qinghai-Tibet Plateau belonged to genomovar 14.
  
  
  CONCLUSIONS
  The distribution of genomovars of Y. pestis in the Qinghai-Tibet plateau had remarkable characteristics geographically. Based on the distribution of genomovars of Y. pestis, the routes of transmission and microevolution of Y. pestis were proposed.
authors.affiliation: Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Er-hei
authors.initials: EH
authors.lastname: Dai
authors.forename: Rui-xia
authors.initials: RX
authors.lastname: Dai
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Zhou
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Yang
authors.forename: Bai-zhong
authors.initials: BZ
authors.lastname: Cui
authors.forename: Li-xia
authors.initials: LX
authors.lastname: Jin
authors.forename: Hai-hong
authors.initials: HH
authors.lastname: Zhao
authors.forename: Cun-xiang
authors.initials: CX
authors.lastname: Li
authors.forename: Mei-ying
authors.initials: MY
authors.lastname: Qi
authors.forename: Dun-zhu
authors.initials: DZ
authors.lastname: Ci Ren
authors.forename: Xiang
authors.initials: X
authors.lastname: Dai
authors.forename: Yong-jiao
authors.initials: YJ
authors.lastname: Tang
authors.forename: Rui-fu
authors.initials: RF
authors.lastname: Yang
mesh_terms: D005075:Biological Evolution; D002681:China; D005843:Geography; D006801:Humans; D010930:Plague / Q000635:transmission*; D015010:Yersinia pestis / Q000235:genetics*