Test-to-test variability in motor activity during the suggested immobilization test in restless legs patients.
OBJECTIVE
To evaluate the test-to-test variability of the suggested immobilization test (SIT) in patients with restless legs syndrome (RLS).


METHODS
Twenty patients with primary RLS (12 men and eight women; age: 53.3+/-11.3 years) were selected for the study. We compared the results of two SITs performed on two consecutive evenings prior to polysomnographic recordings.


RESULTS
Overall, the periodic leg movement index during the SIT (SIT PLM) and the SIT PLM index associated with sensory manifestations (SIT PLM+) were not significantly different between tests. The number of PLM sequences per SIT, the mean PLM duration and the PLM interval did not significantly change between the two consecutive tests. The pattern of temporal evolution of motor activity across the SIT was very reproducible, SIT PLM showing a clear tendency to a progressive increase across the test, with the SIT PLM+ index decreasing in the second half of the test. Despite good reproducibility, there were marked intra-individual differences. Considering the proposed cut-off value of 12 for the SIT PLM index to confirm RLS, 11 patients were positive at the first test and four additional patients became positive at the second test. SIT PLM index changes did not correlate with age, severity of disease and polysomnographic measures.


CONCLUSIONS
Quantitative analysis of motor activity during two consecutive SITs in RLS patients showed a significant inter-test intra-individual variability unrelated to demographic, clinical or polysomnographic parameters. SIT PLM index variability suggests that a single test would not be sensitive enough for diagnostic purposes in unclear cases and that new criteria need to be applied to increase its specificity and sensitivity.
Haba-Rubio
José
J
Sleep Laboratory, Department of Psychiatry, Geneva University Hospital, Geneva, Switzerland.
Sforza
Emilia
E
D000328:Adult; D000367:Age Factors; D000368:Aged; D002940:Circadian Rhythm / Q000502:physiology; D004576:Electromyography; D005260:Female; D006801:Humans; D007103:Immobilization / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010147:Pain Measurement; D017286:Polysomnography; D011237:Predictive Value of Tests; D012146:Rest; D012148:Restless Legs Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D013223:Statistics as Topic