The genetics of health.
Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health.
Nadeau
Joseph H
JH
Department of Genetics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106, USA. jhn4@case.edu
Topol
Eric J
EJ
D005075:Biological Evolution; D064420:Drug-Related Side Effects and Adverse Reactions; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005826:Genetics, Medical; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods* / Q000639:trends*; D012641:Selection, Genetic