Synergistic inhibition of microbial sulfide production by combinations of the metabolic inhibitor nitrite and biocides.
MICs of six broad-spectrum biocides and two specific metabolic inhibitors and fractional inhibitory concentration indexes (FICIs) for controlling a sulfide-producing consortium were determined. Nitrite was synergistic (FICI<1) with all but one biocide due to its specific inhibition of dissimilatory sulfite reductase. Hence, combining nitrite with biocides allows more efficient and cost-effective control of sulfate-reducing bacteria.
Greene
E Anne
EA
Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, Alberta T2N 1N4, Canada.
Brunelle
Veronique
V
Jenneman
Gary E
GE
Voordouw
Gerrit
G
D001548:Benzalkonium Compounds / Q000494:pharmacology; D003901:Desulfovibrio / Q000187:drug effects* / Q000378:metabolism; D004202:Disinfectants / Q000494:pharmacology*; D004357:Drug Synergism; D005976:Glutaral / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009573:Nitrites / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology; D013440:Sulfides / Q000378:metabolism*; D016999:Sulfur-Reducing Bacteria / Q000187:drug effects* / Q000378:metabolism
D001548:Benzalkonium Compounds; D004202:Disinfectants; D009573:Nitrites; D011409:Propylene Glycols; D013440:Sulfides; C006827:bronopol; D005976:Glutaral