title: Cardiac troponin I release in non-ischemic reversible myocardial injury from parvovirus B19 myocarditis.
abstract: Cardiac troponin I is released from myocytes in both reversible and irreversible myocardial injury. The changes in myocyte membrane permeability resulting from the injury could be enough for the release of cardiac troponins from the free cytosolic pool of myocytes without structural damage. We report a case of parvovirus B19 myocarditis in a 26-year-old male who developed regional wall motion abnormalities and severe left ventricular systolic dysfunction with elevated serum levels of cardiac troponin I (peak=11.7 ng/ml). Diagnosis of parvovirus myocarditis was confirmed by presence of high titers of parvovirus B19 IgG and identification of parvovirus B19 DNA by polymerase chain reaction. Within a few days of supportive treatment, the regional wall motion abnormalities resolved, the cardiac function recovered, and the elevation in serum cardiac troponin I subsided. This case further denotes the possibility of release of cardiac troponin I in non-ischemic, reversible myocardial injury.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Baig
authors.forename: Shaukat
authors.initials: S
authors.lastname: Ali
authors.forename: Mutahir U
authors.initials: MU
authors.lastname: Khan
authors.forename: Javeria
authors.initials: J
authors.lastname: Rasheed
authors.forename: Abdul
authors.initials: A
authors.lastname: Qadir
authors.forename: Balendu C
authors.initials: BC
authors.lastname: Vasavada
authors.forename: Ijaz A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000378:metabolism* / Q000821:virology*; D010322:Parvoviridae Infections / Q000150:complications / Q000378:metabolism*; D016732:Parvovirus B19, Human; D019210:Troponin I / Q000378:metabolism*
chemical_list: D019210:Troponin I