title: Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms.
abstract: OBJECTIVE
  To review clinical and pathologic features of Gastrointestinal stromal tumors (GISTs) occurring synchronously with other primary gastrointestinal neoplasms.
  
  
  METHODS
  Twenty-eight patients with primary GIST were treated at our institution between 1989 and 2005. Clinical and pathologic records were reviewed.
  
  
  RESULTS
  The gastrointestinal stromal tumor occurred simultaneously with other primary GI malignancies in 14% of all patients with GIST. The synchronous stromal tumors were located in the stomach and were incidentally found during the operation. The coexistent neoplasms were colon adenocarcinoma, gastric cancer (2 cases) and gastric lymphoma.
  
  
  CONCLUSIONS
  The synchronous occurrence of GISTs and other gastrointestinal malignancies is more common than it has been considered. The development of gastrointestinal stromal tumors and other neoplasms may involve the same carcinogenic agents.
authors.affiliation: Katedra i Klinika Chirurgii Ogolnej, Gastroenterologicznej i Zywienia AM, ul. Banacha 1A, Warsaw 02- 097, Poland. mwronski@coris.com.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Wronski
authors.forename: Bogna
authors.initials: B
authors.lastname: Ziarkiewicz-Wroblewska
authors.forename: Barbara
authors.initials: B
authors.lastname: Gornicka
authors.forename: Wlodzimierz
authors.initials: W
authors.lastname: Cebulski
authors.forename: Maciej
authors.initials: M
authors.lastname: Slodkowski
authors.forename: Aleksander
authors.initials: A
authors.lastname: Wasiutynski
authors.forename: Ireneusz W
authors.initials: IW
authors.lastname: Krasnodebski
mesh_terms: D000368:Aged; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis
chemical_list: D019009:Proto-Oncogene Proteins c-kit