title: Anti-GT1a IgG antibodies in a child with severe Guillain-Barré syndrome.
abstract: This report describes a male, age 8 years 10 months, with severe Guillain-Barré syndrome after Campylobacter jejuni infection. The patient developed fulminant muscle weakness, external ophthalmoplegia, bulbar palsy, and respiratory distress. A high level of serum monospecific anti-GT1a immunoglobulin G antibody was detected. He was treated with intravenous immunoglobulins and artificial ventilation. Two years after the onset, the patient still suffered from residual leg weakness and foot drop. After 3 years and clinical recovery, the antibody was no longer detectable. This report presents the first case in childhood suggesting an association between a severe Guillain-Barré syndrome after C. jejuni enteritis with monospecific anti-GT1a immunoglobulin G antibody.
authors.affiliation: Division of Neuropediatrics and Muscular Disorders, Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Schessl
authors.forename: Kei
authors.initials: K
authors.lastname: Funakoshi
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Susuki
authors.forename: Ralf
authors.initials: R
authors.lastname: Gold
authors.forename: Rudolf
authors.initials: R
authors.lastname: Korinthenberg
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D000918:Antibody Specificity / Q000276:immunology; D002169:Campylobacter Infections / Q000175:diagnosis / Q000276:immunology*; D016123:Campylobacter jejuni; D002648:Child; D004751:Enteritis / Q000175:diagnosis / Q000276:immunology*; D005500:Follow-Up Studies; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D018994:Myosin Light Chains; D009460:Neurologic Examination; D011506:Proteins / Q000276:immunology*; D012121:Respiration, Artificial; D012307:Risk Factors
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; C000599129:MYL4 protein, human; D018994:Myosin Light Chains; D011506:Proteins