Pathway classification of TCA cycle.
The structural analysis of large metabolic networks exhibits a combinatorial explosion of elementary modes. A new method of classification has been developed [called aggregation around common motif (ACoM)], which groups elementary modes into classes with similar substructures. This method is applied to the tricarboxylic acid cycle and metabolite carriers. The analysis of this network evidences a great number of elementary flux modes (204) despite the low number of reactions (23). The ACoM is used to class these elementary modes in a low number of sets (8) with biological meanings.
Pérès
S
S
Physiopathologie Mitochondriale, Inserm U688, University Bordeaux 2, France. sabine.peres@etud.u-bordeaux2.fr
Beurton-Aimar
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M
Mazat
J P
JP
D000222:Adaptation, Physiological / Q000502:physiology; D000465:Algorithms; D000818:Animals; D002468:Cell Physiological Phenomena; D002952:Citric Acid Cycle / Q000502:physiology*; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D020543:Proteome / Q000145:classification / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D020543:Proteome