Use of gene expression microarrays for the study of acute leukemia.
Genetic lesions found in acute leukemia drive the pathology of the disease in addition to forming reliable classifications of prognosis. However, there is still a reasonable heterogeneity of response among cases with the same genetic lesion. Moreover, many leukemia cases have no detectable genetic marker and these cases have marked heterogeneity of response. How can we learn more about the genes and pathways involved with leukemogenesis and response in the midst of such complexity? Gene expression microarrays are experimental platforms that allow for the simultaneous evaluation of the thousands of mRNA transcripts (the 'transcriptome'). This technology has revolutionized the study of leukemia, giving insight into genes and pathways involved in disease response and the biology involved in specific translocations.
Bellido
Mar
M
Fred Hutchinson Cancer Research Center, Clinical Research Division, Public Health Sciences Division, 1100 Fairview Ave N., Seattle, WA 98109, USA. mbellido@cmbi.ru.nl
Stirewalt
Derek L
DL
Zhao
Lue Ping
LP
Radich
Jerald P
JP
D000208:Acute Disease; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011379:Prognosis