[Evaluation of selected acute phase proteins in patients with metabolic syndrome].
Metabolic syndrome is a global epidemic problem. The latest studies revealed that metabolic syndrome can be associated with low-grade chronic inflammation which is postulated to play an essential role in the atherosclerotic process. The aim of the study was evaluation of selected acute phase proteins concentration in patients with metabolic syndrome.


METHODS
30 patients with metabolic syndrome were recruited to the study. The control group comprised 15 healthy persons. In all subjects assessment of C-reactive protein (CRP), alpha1-acid glycoprotein (AGP), alpha1-antichymotrypsin (ACT), ceruloplazmin (Cp), haptoglobin (Hp), alpha2-makroglobulin (alpha2-M), with use of rocket immunoelectroforesis method were performed.


RESULTS
In the group with metabolic syndrome concentration of the studied acute phase proteins significantly exceeded those observed in the control group. Positive correlations between BMI, waist circumference and CRP ACT, AGP, Cp, Hp were found.


CONCLUSIONS
Metabolic syndrome is associated with increased inflammatory process. Visceral obesity is an important determinant of low-grade inflammation in metabolic syndrome. Increased inflammatory process observed in patients with metabolic syndrome should be considered as a potential factor in atherosclerotic process.
Bogdański
Paweł
P
Akademia Medyczna w Poznaniu, Klinika Chorób Wewnetrznych, Zaburzerń Metabolicznych i Nadciśnienia Tetniczego. pawelbogdanski@wp.pl
Chyrek
Robert
R
Pupek-Musialik
Danuta
D
Jabłecka
Anna
A
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D050197:Atherosclerosis / Q000209:etiology / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism; D009961:Orosomucoid / Q000378:metabolism; D012016:Reference Values; D014168:Transferrin / Q000378:metabolism; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D000209:Acute-Phase Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D014168:Transferrin; D000514:alpha 1-Antichymotrypsin; D000511:alpha-Macroglobulins; D002097:C-Reactive Protein