Hemodynamic changes with liver fibrosis measured by dynamic contrast-enhanced MRI in the rat.
OBJECTIVE
To evaluate the hemodynamic changes of liver cirrhosis in the rat and investigate the relationship between hemodynamic changes and properties of fibrotic change in the liver.


METHODS
Three rats with cirrhosis induced by thioacetamide (TAA), three with disease induced by carbon tetrachloride (CCl4), and three with no treatment were measured on dynamic MRI using a 1.5T scanner. Compartment and moment analysis were used to quantitate hemodynamic changes.


RESULTS
Compartment model analysis showed that increased transition speed from vessels to the liver correlated with grade of liver fibrosis. Moment analysis demonstrated that decrease of area under the curve (AUC), mean residence time (MRT), variance of residence time (VRT), half life (T1/2) and increased total clearance (CL) correlated with grade of liver fibrosis.


CONCLUSIONS
Hemodynamic changes in injured fibrotic liver may be influenced by the grade of fibrosis. Compartment model and moment analysis may be useful for evaluating hemodynamic changes in injured liver.
Kubo
Hitoshi
H
Department of Radiologic Technology, School of Health Sciences, The University of Tokushima, Japan. kubo@medsci.tokushima-u.ac.jp
Harada
Masafumi
M
Ishikawa
Makoto
M
Nishitani
Hiromu
H
D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000503:physiopathology; D019540:Area Under Curve; D002251:Carbon Tetrachloride / Q000009:adverse effects; D003287:Contrast Media / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006207:Half-Life; D007089:Image Enhancement; D008102:Liver Circulation / Q000187:drug effects; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012815:Signal Processing, Computer-Assisted; D013853:Thioacetamide / Q000009:adverse effects
D003287:Contrast Media; D013853:Thioacetamide; D002251:Carbon Tetrachloride; D019786:Gadolinium DTPA