title: Use of serum C-reactive protein as an early marker of inflammatory activity in canine type II immune-mediated polyarthritis: case report.
abstract: BACKGROUND
  Monitoring systemic inflammatory activity during steroid therapy of canine immune-mediated polyarthritis (IMPA) is difficult and mainly relies on clinical signs.
  
  
  METHODS
  Canine serum C-reactive protein (CRP) was measured serially and blinded during a 27-week follow-up period of a case of Anaplasma phagocytophilia induced type II immune-mediated polyarthritis.
  
  
  CONCLUSIONS
  WBC was, as expected, observed not to reflect the inflammatory activity during steroid treatment in a clinical useful manner, whereas, CRP is suggested a valuable unbiased marker of inflammatory activity during steroid treatment in this case.
authors.affiliation: Central Laboratory, Department of Small Animal Clinical Sciences, The Royal Veterinary and Agricultural University, 3 Gronnegaardsvej, DK-1870 Frederiksberg, Denmark. mjkh@kvl.dk
authors.forename: Mads
authors.initials: M
authors.lastname: Kjelgaard-Hansen
authors.forename: Asger Lundorff
authors.initials: AL
authors.lastname: Jensen
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Houser
authors.forename: Lisbeth Rem
authors.initials: LR
authors.lastname: Jessen
authors.forename: Annemarie T
authors.initials: AT
authors.lastname: Kristensen
mesh_terms: D041081:Anaplasma phagocytophilum / Q000302:isolation & purification; D000743:Anemia, Hemolytic / Q000209:etiology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000907:Antibodies, Bacterial / Q000097:blood; D001168:Arthritis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D004285:Dogs; D004318:Doxycycline / Q000008:administration & dosage; D016873:Ehrlichiosis / Q000175:diagnosis / Q000662:veterinary; D005260:Female; D005500:Follow-Up Studies; D007249:Inflammation / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary; D011239:Prednisolone / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000907:Antibodies, Bacterial; D015415:Biomarkers; D002097:C-Reactive Protein; D011239:Prednisolone; D004318:Doxycycline