title: Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position.
abstract: Eleven C2-substituted derivatives of resveratrol (trans-3,4',5-trihydroxystilbene, RES) were prepared by partial synthesis from RES and evaluated for their cytotoxic activities against a human nasopharyngeal epidermoid tumor cell line KB. Among them, compounds 2 and 3 were more active than 5-fluorouracil (5-FU), an anticancer drug, and compound 5f exhibited similar activity to 5-FU. On the basis of the biological results, structure-activity relationships were discussed.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Huang
authors.forename: Ban-Feng
authors.initials: BF
authors.lastname: Ruan
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Wang
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
authors.forename: Ren-Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D013267:Stilbenes; D000077185:Resveratrol