Serum adiponectin and coronary heart disease risk in older Black and White Americans.
BACKGROUND
Adiponectin may influence the risk of coronary heart disease (CHD) independently of traditional cardiovascular risk factors.


OBJECTIVE
Because body composition and adiponectin levels vary by race, we examined the relationship of adiponectin with prevalent and incident CHD in a cohort of older Black and White adults.


METHODS
We conducted a cross-sectional and prospective cohort study at two U.S. clinical centers.


METHODS
Participants included 3075 well-functioning adults between ages 70 and 79 yr enrolled in the Health, Aging, and Body Composition study.


METHODS
Prevalent CHD was defined as history of myocardial infarction, coronary artery bypass graft, percutaneous coronary transluminal angioplasty, angina, or major electrocardiogram abnormalities. After excluding those with prevalent CHD, incident CHD was defined as hospitalized myocardial infarction or CHD death.


RESULTS
At baseline, 602 participants (19.6%) had CHD. During 6 yr of follow-up, 262 (10.6%) incident CHD events occurred. Whites had higher median adiponectin than Blacks (12 vs. 8 microg/ml, P < 0.001). Race modified the effect of adiponectin (P for interaction was 0.002 for prevalent CHD, and P = 0.02 for incident CHD). Among Whites, an inverse association of adiponectin with CHD was explained by high-density lipoprotein and glucose. Among Blacks, a doubling of adiponectin was associated with a 40% higher risk of both prevalent CHD (odds ratio, 1.41; 95% confidence interval, 1.11-1.78) and incident CHD (hazards ratio, 1.37; 95% confidence interval, 1.01-1.87) after adjusting for explanatory variables.


CONCLUSIONS
High circulating concentrations of adiponectin were associated with higher risk of CHD in older Blacks, even accounting for traditional CHD risk factors.
Kanaya
Alka M
AM
Univerisity of California, San Francisco, California 94115, USA. Alka.Kanaya@ucsf.edu
Wassel Fyr
Christina
C
Vittinghoff
Eric
E
Havel
Peter J
PJ
Cesari
Matteo
M
Nicklas
Barbara
B
Harris
Tamara
T
Newman
Anne B
AB
Satterfield
Suzanne
S
Cummings
Steve R
SR
D052242:Adiponectin / Q000097:blood*; D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data
D052242:Adiponectin