[The significance of the serum tumour markers as a prognostic and predictor factors in nonsmall cell lung cancer patients].
The aim of the study was to assess the role of serum tumour markers (NSE, Cyfra 21-1, CEA, LDH, ferritin) as a prognostic and predictive factors in 79 patients with advanced NSCLC treated with chemotherapy. Objective response to treatment was significantly more frequent in the patient with serum NSE > 12.5 ng/ml. Progression of disease was observed more often in patients with serum Cyfra 21-1 >10 ng/ml or LDH >480 U/L. CEA >3 ng/ml, LDH >480 U/L, for coefficient >1, NSE >20 ng/ml and Cyfra 21-1 >10 ng/ml had a negative impact on survival in univariate analysis. Independent negative prognostic significance of fer coefficient >1 was confirmed by multivariate analysis.
Załeska
Monika
M
Instytutu Gruźlicy i Chorób Płuc, Warszawie.
Szturmowicz
Monika
M
Zych
Jacek
J
Remiszewski
Paweł
P
Płodziszewskal
Monika
M
Szopiński
Janusz
J
Załeska
Jolanta
J
Demkow
Urszula
U
Langfort
Renata
R
Roszkowska-Sliz
Barbara
B
Roszkowski-Sliz
Kazimierz
K
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009363:Neoplasm Proteins / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D044967:Serum / Q000276:immunology; D016019:Survival Analysis; D015996:Survival Rate
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053539:Keratin-19; D018396:Mucin-1; D009363:Neoplasm Proteins; C102012:antigen CYFRA21.1; D007633:Keratins