Luminal fillers in nerve conduits for peripheral nerve repair.
The use of nerve conduits as an alternative for nerve grafting has a long experimental and clinical history. Luminal fillers, factors introduced into these nerve conduits, were later developed to enhance the nerve regeneration through conduits. Though many luminal fillers have been reported to improve nerve regeneration, their use has not been subjected to systematic review. This review categorizes the types of fillers used, the conduits associated with fillers, and the reported performance of luminal fillers in conduits to present a preference list for the most effective fillers to use over specific distances of nerve defect.
Chen
Michael B
MB
Division of Plastic Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Zhang
Feng
F
Lineaweaver
William C
WC
D001672:Biocompatible Materials; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology; D009493:Neurosurgery / Q000295:instrumentation*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000601:surgery*; D010523:Peripheral Nervous System Diseases / Q000601:surgery*; D019736:Prostheses and Implants; D014945:Wound Healing / Q000502:physiology
D001672:Biocompatible Materials