title: The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis.
abstract: For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-beta in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-beta level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.
authors.affiliation: Institute of Basic Theory, China Academy of Traditional Chinese Medicine, Beijing, PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiao
authors.forename: Cheng
authors.initials: C
authors.lastname: Lu
authors.forename: Linhua
authors.initials: L
authors.lastname: Zhao
authors.forename: Zhenli
authors.initials: Z
authors.lastname: Liu
authors.forename: Wandong
authors.initials: W
authors.lastname: Zhang
authors.forename: Yinghui
authors.initials: Y
authors.lastname: He
authors.forename: Shilin
authors.initials: S
authors.lastname: Chen
authors.forename: Johnny Cheuk-on
authors.initials: JC
authors.lastname: Tang
authors.forename: Albert Sun-chi
authors.initials: AS
authors.lastname: Chan
authors.forename: Aiping
authors.initials: A
authors.lastname: Lu
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010581:Peyer's Patches / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000187:drug effects; D029757:Tripterygium
chemical_list: D007166:Immunosuppressive Agents; D010936:Plant Extracts; D016212:Transforming Growth Factor beta