title: The MitoDrome database annotates and compares the OXPHOS nuclear genes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae.
abstract: The oxidative phosphorylation (OXPHOS) is the primary energy-producing process of all aerobic organisms and the only cellular function under the dual control of both the mitochondrial and the nuclear genomes. Functional characterization and evolutionary study of the OXPHOS system is of great importance for the understanding of many as yet unclear aspects of nucleus-mitochondrion genomic co-evolution and co-regulation gene networks. The MitoDrome database is a web-based database which provides genomic annotations about nuclear genes of Drosophila melanogaster encoding for mitochondrial proteins. Recently, MitoDrome has included a new section annotating genomic information about OXPHOS genes in Drosophila pseudoobscura and Anopheles gambiae and their comparative analysis with their Drosophila melanogaster and human counterparts. The introduction of this new comparative annotation section into MitoDrome is expected to be a useful resource for both functional and structural genomics related to the OXPHOS system.
authors.affiliation: Institute for Biomedical Technologies, CNR, Via Amendola 122/D, 70126 Bari, Italy. domenica.delia@ba.itb.cnr.it
authors.forename: Domenica
authors.initials: D
authors.lastname: D'Elia
authors.forename: Domenico
authors.initials: D
authors.lastname: Catalano
authors.forename: Flavio
authors.initials: F
authors.lastname: Licciulli
authors.forename: Antonio
authors.initials: A
authors.lastname: Turi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Tripoli
authors.forename: Damiano
authors.initials: D
authors.lastname: Porcelli
authors.forename: Cecilia
authors.initials: C
authors.lastname: Saccone
authors.forename: Corrado
authors.initials: C
authors.lastname: Caggese
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics*; D005075:Biological Evolution; D030561:Databases, Nucleic Acid; D004330:Drosophila / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics; D017344:Genes, Insect; D006801:Humans; D008928:Mitochondria / Q000235:genetics; D010085:Oxidative Phosphorylation; D014584:User-Computer Interface