Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug.
Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.
Fukuuchi
Tomoko
T
Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. t-fukuu@ps.hirokoku-u.ac.jp <t-fukuu@ps.hirokoku-u.ac.jp>
Doh-Ura
Katsumi
K
Yoshihara
Shin'ichi
S
Ohta
Shigeru
S
D002460:Cell Line; D002614:Chelating Agents / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D011328:Prions / Q000378:metabolism*; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D002614:Chelating Agents; D011328:Prions; D003300:Copper; D013482:Superoxide Dismutase