Rapamycin biosynthesis: Elucidation of gene product function.
The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene complementation.
Gregory
Matthew A
MA
Biotica, Chesterford Research Park, Little Chesterford, UK CB10 1XL.
Hong
Hui
H
Lill
Rachel E
RE
Gaisser
Sabine
S
Petkovic
Hrvoje
H
Low
Lindsey
L
Sheehan
Lesley S
LS
Carletti
Isabelle
I
Ready
Sarah J
SJ
Ward
Michael J
MJ
Kaja
Andrew L
AL
Weston
Alison J
AJ
Challis
Iain R
IR
Leadlay
Peter F
PF
Martin
Christine J
CJ
Wilkinson
Barrie
B
Sheridan
Rose M
RM
D005796:Genes; D005816:Genetic Complementation Test; D013058:Mass Spectrometry; D020123:Sirolimus / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism*
D020123:Sirolimus