Russujaponols A-F, illudoid sesquiterpenes from the fruiting body of Russula japonica.
Six new illudoid sesquiterpenes, russujaponols A-F (1-6), were isolated from the fruiting bodies of Russula japonica Hongo. Their structures were established primarily by 2D NMR experiments, and the structure of the main compound, russujaponol A (1), was confirmed by X-ray crystallographic analysis of its benzoate (1a). Russujaponol A (1) suppressed invasion of human fibrosarcoma (HT1080) cells into Matrigel in a concentration-dependent manner and caused 63% inhibition at 3.73 microM.
Yoshikawa
Kazuko
K
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima 770-8514, Japan. yosikawa@ph.bunri-u.ac.jp
Kaneko
Azusa
A
Matsumoto
Yuki
Y
Hama
Hiroshi
H
Arihara
Shigenobu
S
D000970:Antineoplastic Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007564:Japan; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D004317:Doxorubicin