title: Food groups and risk of hepatocellular carcinoma: A multicenter case-control study in Italy.
abstract: The role of diet, except for alcohol drinking and aflatoxin contamination, in the etiology of hepatocellular carcinoma (HCC) is unclear. A hospital-based case-control study was conducted in Italy in 1999-2002, including 185 incident, histologically-confirmed cases of HCC. Controls were 412 subjects admitted to hospitals for acute, nonneoplastic diseases unrelated to diet. Dietary habits were assessed using a validated food-frequency questionnaire. Odds ratios (ORs) and the corresponding 95% confidence intervals (CI) were computed using unconditional multiple logistic regression, adjusting for hepatitis B (HBV) and hepatitis C (HCV) virus infection and alcohol drinking. Energy adjustment was carried out by means of the residual model. A significant inverse relation was found between intakes of milk and yoghurt (OR = 0.28; 95% CI: 0.13-0.61), white meats (OR = 0.44; 95% CI: 0.20-0.95), eggs (OR = 0.31; 95% CI: 0.14-0.69), and fruits (OR = 0.48; 95% CI: 0.22-1.05) and HCC risk. The favourable effect of high intakes of milk and yoghurt, white meats, eggs and fruits was consistent across strata of HBV and HCV infections. The present study supports the hypothesis of a role of diet in HCC aetiology. Dietary modifications may be indicated in subjects at high-risk for HCC.
authors.affiliation: Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy. talaminir@cro.it
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Jerry
authors.initials: J
authors.lastname: Polesel
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Anna
authors.initials: A
authors.lastname: Crispo
authors.forename: Luigi G
authors.initials: LG
authors.lastname: Tommasi
authors.forename: Francesco
authors.initials: F
authors.lastname: Izzo
authors.forename: Marina
authors.initials: M
authors.lastname: Crovatto
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology*; D016022:Case-Control Studies; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D005502:Food; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D011795:Surveys and Questionnaires