Facile synthesis of substituted thiophenes via Pd/C-mediated sonogashira coupling in water.
The first successful Pd/C-mediated Sonogashira coupling of iodothiophene with terminal alkynes in water is described here. Pd/C-CuI-PPh(3) was found to be an efficient catalyst system for this coupling reaction. Using this economic and reliable process a variety of acetylenic thiophenes with a wide range of functional groups were prepared in good yields. Synthetic applications and in vitro anticancer properties of some of the compounds synthesized are described.
Raju
Sirisilla
S
Custom Pharmaceutical Services, Bollaram Road, Miyapur, Hyderabad 500049, India.
Kumar
P Rajender
PR
Mukkanti
K
K
Annamalai
Pazhanimuthu
P
Pal
Manojit
M
D002244:Carbon; D007202:Indicators and Reagents; D047028:Macrocyclic Compounds / Q000737:chemistry*; D010165:Palladium; D013876:Thiophenes / Q000138:chemical synthesis*; D014867:Water
D007202:Indicators and Reagents; D047028:Macrocyclic Compounds; D013876:Thiophenes; D014867:Water; D010165:Palladium; D002244:Carbon