title: Anti-beta2 glycoprotein 1 and the anti-phospholipid syndrome.
abstract: OBJECTIVE
  To describe a patient who presented with bilateral retinal vascular occlusion and the use of anti-beta2 glycoprotein 1 (GPI) antibody testing in the diagnosis of antiphospholipid syndrome.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  Hematological investigations were performed on a 49-year-old man who presented with rapid onset of bilateral severe central retinal vein occlusion.
  
  
  RESULTS
  Lupus anticoagulant and anticardiolipin antibody testing was negative. Markedly raised titers of anti-beta2 GPI antibodies were detected on two separate occasions.
  
  
  CONCLUSIONS
  The raised titers of anti-beta2 GPI antibodies were considered to strongly suggest an underlying diagnosis of the antiphospholipid syndrome.
authors.affiliation: Department of Ophthalmology, Cork University Hospital, Cork, Ireland. pearsek@iol.ie
authors.forename: Pearse A
authors.initials: PA
authors.lastname: Keane
authors.forename: Kesavan
authors.initials: K
authors.lastname: Ravikumar
authors.forename: Susan I
authors.initials: SI
authors.lastname: O'shea
authors.forename: Philip E
authors.initials: PE
authors.lastname: Cleary
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000175:diagnosis*; D001053:Apolipoproteins / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D001766:Blindness / Q000473:pathology; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000175:diagnosis*; D053482:beta 2-Glycoprotein I
chemical_list: D017153:Antibodies, Anticardiolipin; D001053:Apolipoproteins; D001323:Autoantibodies; D006023:Glycoproteins; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I