Alleles 308A and 238A in the tumor necrosis factor alpha gene promoter do not increase the risk of severe malaria in children with Plasmodium falciparum infection in Mali.
The hypothesis that tumor necrosis factor (TNF) aggravates malaria in children is supported by observations that TNF polymorphisms and high TNF levels have been associated with cerebral malaria. Nevertheless, severe malaria was not associated with polymorphisms located at positions -308A and -238A in the TNF alpha gene promoter or with a high TNF level in plasma in children from Bamako, Mali.
Cabantous
Sandrine
S
Immunology and Genetics of Parasitic Diseases, INSERM UMR399, Faculty of Medicine Timone, 27 Blvd. Jean Moulin, Marseille 13385 Cedex 5, France.
Doumbo
Ogobara
O
Ranque
Stéphane
S
Poudiougou
Belco
B
Traore
Abdoulaye
A
Hou
Xunya
X
Keita
Marouf M
MM
Cisse
Mahamadou B
MB
Dessein
Alain J
AJ
Marquet
Sandrine
S
D000483:Alleles; D000818:Animals; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016778:Malaria, Falciparum / Q000235:genetics*; D008297:Male; D008302:Mali; D010963:Plasmodium falciparum; D011401:Promoter Regions, Genetic / Q000235:genetics; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha