Analgesic, antiinflammatory, and ulcerogenic studies of meloxicam solid dispersion prepared with polyethylene glycol 6000.
Meloxicam is a nonsteroidal antiinflammatory drug, used in the treatment of rheumatoid arthritis and oestoarthritis. It is practically insoluble in water, leading to poor dissolution, variations in bioavailability, and gastric irritation on oral administration. In the attempt to reduce its gastric side effect and to increase aqueous solubility, physical mixture and solid dispersion of the drug were prepared with polyethylene glycol 6000. The analgesic, antiinflammatory, and ulcerogenic effects were assessed for physical mixture and solid dispersion in comparison with meloxicam alone. The results indicate that both physical mixture and solid dispersion possess better analgesic and antiinflammatory properties with less ulcerogenic potential when compared with pure meloxicam.
Vijaya Kumar
S G
SG
Department of Pharmaceutical Sciences, Guru Jambheshwar University, Hisar, Haryana, India.
Mishra
D N
DN
D015746:Abdominal Pain / Q000139:chemically induced / Q000517:prevention & control*; D019342:Acetic Acid / Q000008:administration & dosage / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D002351:Carrageenan / Q000008:administration & dosage / Q000633:toxicity; D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D006614:Hindlimb / Q000187:drug effects / Q000503:physiopathology; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D000077239:Meloxicam; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013843:Thiazines / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D013844:Thiazoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004304:Dosage Forms; D013843:Thiazines; D013844:Thiazoles; D011092:Polyethylene Glycols; D002351:Carrageenan; D019342:Acetic Acid; D000077239:Meloxicam