Role of oxidative stress in experimental sepsis and multisystem organ dysfunction.
Massive increase in radical species can lead to oxidative stress, promoting cell injury and death. This review focuses on experimental evidence of oxidative stress in critical illnesses, sepsis and multisystem organ dysfunction. Oxidative stress could negatively affect organ injury and thus overall survival of experimental models. Based on this experimental evidence, we could improve the rationale of supplementation of antioxidants alone or in combination with standard therapies aimed to reduce oxidative stress as novel adjunct treatment in critical care.
Crimi
Ettore
E
Department of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, Novara, Italy. ecrimi@hotmail.com
Sica
Vincenzo
V
Slutsky
Arthur S
AS
Zhang
Haibo
H
Williams-Ignarro
Sharon
S
Ignarro
Louis J
LJ
Napoli
Claudio
C
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000378:metabolism; D018805:Sepsis / Q000188:drug therapy* / Q000378:metabolism
D000975:Antioxidants; D017382:Reactive Oxygen Species