Secondary metabolites and insecticidal activity of Anemone pavonina.
The insecticidal properties of the crude extracts of the leaves and flowers of Anemone pavonina were evaluated on Pheidole pallidula ants and showed significant levels of activity. Bioassay-guided fractionations led to the isolation of the butenolide ranunculin (1) as the active principle. Chemical investigations of the extracts showed them to contain as major components the sitosterol glycopyranoside lipids 2-5 and the glycerides 6-8. The structures of the metabolites were elucidated, following acetylation and hydrolysis of the natural products, by interpretation of their NMR and mass spectral data. The uncommon lipid metabolites 2-8 were isolated for the first time from the genus Anemone and this is the first report of insecticidal activity of the Anemone metabolite ranunculin against ants.
Varitimidis
Christos
C
University of Athens, School of Pharmacy, Department of Pharmacognosy and Chemistry of Natural Products, Panepistimiopolis Zografou, 157 71 Athens, Greece.
Petrakis
Panos V
PV
Vagias
Constantinos
C
Roussis
Vassilios
V
D031883:Anemone / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001000:Ants; D005260:Female; D035264:Flowers / Q000737:chemistry; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007306:Insecticides / Q000302:isolation & purification* / Q000494:pharmacology*; D008759:Methylglycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D014020:Tissue Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D005663:Furans; D007306:Insecticides; D008759:Methylglycosides; D014020:Tissue Extracts; C039859:ranunculin