title: Two new scorpionates vanadium haloperoxidases model complexes: synthesis and structure of VO(O2)(pzH)(HB(pz)3) and VO(O2)(pzH)(B(pz)4) (pzH = pyrazole(C3H4N2)).
abstract: Using vanadate, poly(1H-pyrazol-1-yl)borate and pyrazole as starting materials, two new neutral peroxovanadium(V) complexes with poly(1H-pyrazol-1-yl)borate, VO(O(2))(pzH)(HB(pz)(3))(1) and VO(O(2))(pzH)(B(pz)(4))(2), were synthesized successfully. Both complexes were characterized by elemental analysis, IR, UV-vis and NMR spectra. And the structure of complex 1 was determined by X-ray diffraction, which is somewhat relevant for haloperoxidase enzymes. Cytotoxic effects also are discussed on 3T3 cell proliferation. In the concentration range (0.1-100mumol), both complexes have an inhibiting cellular proliferation effect. When the cells cultivated with the complexes at high dose, the toxicity effect of both complexes is more and more predominant.
authors.affiliation: Bioinorganic Laboratory, Liaoning Normal University, Dalian 116029, PR China. yhxing2000@yahoo.com
authors.forename: Yongheng
authors.initials: Y
authors.lastname: Xing
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Sun
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
authors.forename: Yongting
authors.initials: Y
authors.lastname: Xu
authors.forename: Maofa
authors.initials: M
authors.lastname: Ge
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhang
authors.forename: Shuyun
authors.initials: S
authors.lastname: Niu
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010544:Peroxidases / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017968:Vanadium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D011720:Pyrazoles; D017968:Vanadium Compounds; D010544:Peroxidases