Bilateral diffuse melanocytic proliferation associated with ovarian carcinoma and metastatic malignant amelanotic melanoma.
OBJECTIVE
To report a case of metastatic malignant amelanotic melanoma to the skin from a patient diagnosed with bilateral diffuse uveal melanocytic proliferation (BDUMP). This dermatological finding is a unique phenomenon associated with BDUMP.


METHODS
Retrospective case report.


METHODS
We studied the case of a 66-year-old Caucasian woman with gradual onset of blurred vision in her right eye followed by her left eye. She had previously been diagnosed with ovarian carcinoma, and findings of funduscopic examinations were consistent with BDUMP. Metastatic examination revealed no evidence of liver involvement. Clinical and histopathological examinations of both enucleated eyes were consistent with BDUMP.


RESULTS
The hematoxylin and eosin, S-100, and HMB-45 stains were consistent with metastatic malignant amelanotic melanoma to the skin.


CONCLUSIONS
Although believed to have a low potential for metastasis, patients should be monitored and evaluated regularly to detect any new lesions not associated with their primary inciting carcinoma.
Duong
Hon-Vu Q
HV
Department of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA. Tenthsfg@msn.com
McLean
Ian W
IW
Beahm
Donald E
DE
D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D049109:Cell Proliferation; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008544:Melanocytes / Q000473:pathology*; D018328:Melanoma, Amelanotic / Q000737:chemistry / Q000556:secondary*; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000556:secondary*; D014603:Uveal Diseases / Q000175:diagnosis*
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins