title: Prospective comparison of secretin-stimulated magnetic resonance cholangiopancreatography with manometry in the diagnosis of sphincter of Oddi dysfunction types II and III.
abstract: BACKGROUND
  In sphincter of Oddi dysfunction (SOD), sphincter of Oddi manometry (SOM) predicts the response to sphincterotomy, but is invasive and associated with complications.
  
  
  OBJECTIVE
  To evaluate the role of secretin-stimulated magnetic resonance cholangiopancreatography (ss-MRCP) in predicting the results of SOM in patients with suspected type II or III SOD.
  
  
  METHODS
  MRCP was performed at baseline and at 1, 3, 5 and 7 min after intravenous secretin. SOD was diagnosed when the mean basal sphincter pressure at SOM was >40 mm Hg. Long-term outcome after SOM, with or without endoscopic sphincterotomy, was assessed using an 11-point (0-10) Likert scale.
  
  
  RESULTS
  Of 47 patients (male/female 9/38; mean age 46 years; range 27-69 years) referred for SOM, 27 (57%) had SOD and underwent biliary and/or pancreatic sphincterotomy. ss-MRCP was abnormal in 10/16 (63%) type II and 0/11 type III SOD cases. The diagnostic accuracy of ss-MRCP for SOD types II and III was 73% and 46%, respectively. During a mean follow-up of 31.6 (range 17-44) months, patients with normal SOM and SOD type II experienced a significant reduction in symptoms (mean Likert score 8 vs 4; p = 0.03, and 9 vs 1.6; p = 0.0002, respectively), whereas in patients with SOD type III, there was no improvement in pain scores. All patients with SOD and an abnormal ss-MRCP (n = 12) reported long-term symptom improvement (mean Likert score 9.2 v 1.2, p<0.001).
  
  
  CONCLUSIONS
  ss-MRCP is insensitive in predicting abnormal manometry in patients with suspected type III SOD, but is useful in selecting patients with suspected SOD II who are most likely to benefit from endotherapy.
authors.affiliation: Department of Gastroenterology, University College London Hospitals NHS Trust, London, UK. stephen.pereira@ucl.ac.uk
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Pereira
authors.forename: Alice
authors.initials: A
authors.lastname: Gillams
authors.forename: Spiros N
authors.initials: SN
authors.lastname: Sgouros
authors.forename: George J M
authors.initials: GJ
authors.lastname: Webster
authors.forename: Adrian R W
authors.initials: AR
authors.lastname: Hatfield
mesh_terms: D000328:Adult; D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D005500:Follow-Up Studies; D005765:Gastrointestinal Agents; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010195:Pancreatitis / Q000209:etiology; D018579:Patient Selection; D011446:Prospective Studies; D012633:Secretin; D009803:Sphincter of Oddi / Q000601:surgery; D046628:Sphincter of Oddi Dysfunction / Q000175:diagnosis* / Q000601:surgery; D016717:Sphincterotomy, Endoscopic; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D012633:Secretin