title: Quassinoid support studies: fused carbocycle synthesis from benzoic acid derivatives via 5-hexynyl and 6-heptynyl radical cyclizations.
abstract: Eight bromoalkynes were prepared from substituted benzoic acids and treated with n-Bu3SnH to provide trans-fused perhydroindans or cis- and trans-fused perhydronaphthalenes. Atom-transfer reactions that accompany the free radical reactions resulted in several tandem radical cyclizations with formation of up to three carbon-carbon bonds in a single reaction. The relationship between these reactions and an approach to the quassinoid family of natural products is also described.
authors.affiliation: Department of Chemistry, Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Valerie
authors.initials: V
authors.lastname: Cwynar
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Donahue
authors.forename: David J
authors.initials: DJ
authors.lastname: Hart
authors.forename: Dexi
authors.initials: D
authors.lastname: Yang