Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer.
Cutaneous lesions consonant with Muir-Torre syndrome strongly suggest hereditary non-polyposis colorectal cancer (HNPCC). Ponti et al. discuss the importance of combining molecular genetic features of the sebaceous neoplasms, including microsatellite instability and immunohistochemistry, with family history, to determine the likelihood of HNPCC. Proof of diagnosis is identification of one of the mismatch repair germline mutations.
Lynch
Henry T
HT
Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA. htlynch@creighton.edu
Fusaro
Ramon M
RM
Lynch
Patrick M
PM
D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics* / Q000473:pathology; D042822:Genomic Instability; D006801:Humans; D007150:Immunohistochemistry; D007636:Keratoacanthoma / Q000235:genetics*; D018895:Microsatellite Repeats; D012626:Sebaceous Gland Neoplasms / Q000235:genetics*; D012627:Sebaceous Glands / Q000473:pathology*