Hydruric response in Wistar and vasopressin-deficient Brattleboro rats to water load under conditions of increased brain serotonin level.
The hydruric response to water load in Wistar rats and homozygous Brattleboro rats with a hereditary defect in the synthesis of vasopressin was studied under conditions of increased brain serotonin level. Serotonin prevented the reduction in reabsorption of osmotically free water in normal rats, but had no effect in vasopressin-deficient Brattleboro rats. Our results suggest that serotonin stimulates vasopressin secretion and interacts with the vasopressinergic system during the realization of osmotic regulation.
Ivanova
L N
LN
Laboratory of Physiological Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. ludiv@bionet.nsc.ru
Kochkaeva
L N
LN
Melidi
N N
NN
D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004231:Diuresis; D007668:Kidney / Q000502:physiology; D051381:Rats; D011910:Rats, Brattleboro; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D014667:Vasopressins / Q000172:deficiency / Q000235:genetics; D014867:Water / Q000008:administration & dosage*; D014882:Water-Electrolyte Balance
D014867:Water; D014667:Vasopressins; D012701:Serotonin