title: Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents.
abstract: Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed.
authors.affiliation: Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. dennis_feng@merck.com <dennis_feng@merck.com>
authors.forename: Dennis
authors.initials: D
authors.lastname: Feng
authors.forename: Michael
authors.initials: M
authors.lastname: Fisher
authors.forename: Gui-Bai
authors.initials: GB
authors.lastname: Liang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Qian
authors.forename: Chris
authors.initials: C
authors.lastname: Brown
authors.forename: Anne
authors.initials: A
authors.lastname: Gurnett
authors.forename: Penny Sue
authors.initials: PS
authors.lastname: Leavitt
authors.forename: Paul A
authors.initials: PA
authors.lastname: Liberator
authors.forename: John
authors.initials: J
authors.lastname: Mathew
authors.forename: Andrew
authors.initials: A
authors.lastname: Misura
authors.forename: Samantha
authors.initials: S
authors.lastname: Samaras
authors.forename: Tamas
authors.initials: T
authors.lastname: Tamas
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Schmatz
authors.forename: Matthew
authors.initials: M
authors.lastname: Wyvratt
authors.forename: Tesfaye
authors.initials: T
authors.lastname: Biftu
mesh_terms: D000818:Animals; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004539:Eimeria / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C515886:2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo(1,2-a)pyridine; D003049:Coccidiostats; D007093:Imidazoles; D011725:Pyridines; C023666:pyridine