Regulation of ribosome biogenesis: where is TOR?
Li et al., (2006) have shown that TOR complex 1 in yeast binds directly to the rDNA promoter and thereby activates Pol I-dependent synthesis of 35S RNA. This is an important advance in the understanding of how ribosome biogenesis is regulated in response to environmental conditions.
Martin
Dietmar E
DE
Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Powers
Ted
T
Hall
Michael N
MN
D004275:DNA, Ribosomal / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D012270:Ribosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D004275:DNA, Ribosomal; D012321:DNA-Directed RNA Polymerases; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D012313:RNA; D029701:Saccharomyces cerevisiae Proteins; C083324:TOR1 protein, S cerevisiae