The effect of atorvastatin therapy on lecithin:cholesterol acyltransferase, cholesteryl ester transfer protein and the antioxidant paraoxonase.
OBJECTIVE
The aim of our study was to examine the influence of atorvastatin on lipid parameters, particularly on HDL, and on the activity of LCAT and CETP and how they affect the activity of the HDL-associated antioxidant enzyme paraoxonase.


METHODS
Thirty-three patients with types II.a and II.b primary hyperlipoproteinemia were enrolled into our study. The patients received atorvastatin, 20 mg daily, for 3 months. We measured the serum paraoxonase activity and concentration, oxidized LDL, LCAT and CETP activities.


RESULTS
Atorvastatin significantly reduced the levels of cholesterol, triglyceride, LDL-C and apoB, while it did not influence the levels of HDL-C and apo A-I. The increases in serum PON-specific activity, PON/HDL ratio and LCAT activity were significant, while oxLDL and CETP activities were significantly decreased.


CONCLUSIONS
Atorvastatin may influence the composition and function of HDL, thereby possibly increasing the activity of paraoxonase and preventing atherosclerosis.
Kassai
Andrea
A
1st Department of Medicine, University of Debrecen, Medical and Health Science Centre, Nagyerdei krt. 98, H-4012 Debrecen, Hungary.
Illyés
László
L
Mirdamadi
Hossein Z
HZ
Seres
Ildiko
I
Kalmár
Tímea
T
Audikovszky
Mária
M
Paragh
György
G
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis*; D001053:Apolipoproteins / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood*; D000069059:Atorvastatin; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood*; D005260:Female; D006538:Heptanoic Acids / Q000494:pharmacology*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D011758:Pyrroles / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D000975:Antioxidants; D001053:Apolipoproteins; D053480:Cholesterol Ester Transfer Proteins; D006538:Heptanoic Acids; D008075:Lipoproteins, HDL; D011758:Pyrroles; D000069059:Atorvastatin; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D043303:Aryldialkylphosphatase