A stability switch for proteins.
A paper published in the September 8 issue of Cell describes a generally applicable approach for chemical control of protein stability, with potential for broad use in chemical genetics.
Clackson
Tim
T
ARIAD Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.
D000818:Animals; D005434:Flow Cytometry; D006801:Humans; D008024:Ligands; D016296:Mutagenesis; D015202:Protein Engineering; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics; D022021:Tacrolimus Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
D008024:Ligands; D011506:Proteins; D034741:RNA, Small Interfering; D022021:Tacrolimus Binding Proteins