title: Antibacterial principles from Myristica fragrans seeds.
abstract: Nutmeg (Myristica fragrans) is used in food preparations for its aromatic flavor. The present investigation was undertaken to evaluate the antibacterial activity of constituents of M. fragrans seeds. Seeds of M. fragrans were powdered and extracted with chloroform to obtain trimyristin, which on saponification yielded myristic acid. The mother liquor remaining after separation of trimyristin was concentrated and column-chromatographed with petroleum ether to separate myristicin. Antibacterial activity of these isolated constituents was evaluated by determination of minimum inhibitory concentration against selected Gram-positive and Gram-negative organisms. All the constituents isolated from nutmeg exhibited good antibacterial activity. This study shows the potential of natural compounds in replacement of synthetic preservatives.
authors.affiliation: Department of Pharmaceutical Sciences, Guru Jambheshwar University, Hisar, Haryana, India.
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Narasimhan
authors.forename: Avinash S
authors.initials: AS
authors.lastname: Dhake
mesh_terms: D000081248:Allylbenzene Derivatives; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000302:isolation & purification / Q000494:pharmacology; D002725:Chloroform; D004148:Dioxolanes / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D019814:Myristic Acid / Q000302:isolation & purification / Q000494:pharmacology; D026323:Myristica / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D011748:Pyrogallol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry*; D014280:Triglycerides / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000081248:Allylbenzene Derivatives; D000900:Anti-Bacterial Agents; D001593:Benzyl Compounds; D004148:Dioxolanes; D010936:Plant Extracts; D014280:Triglycerides; D011748:Pyrogallol; C005246:myristicin; D019814:Myristic Acid; C036694:trimyristin; D002725:Chloroform