title: Cu2+ and AMP complexation of enlarged tripodal polyamines.
abstract: The synthesis, characterization, Cu2+ coordination and interaction with AMP of three tripodal polyamines are reported. The polyamines are based on the structure of the tetraamine (tren) which has been enlarged with three propylamino functionalities (), with a further anthrylmethyl fragment at one of its terminal primary nitrogens () or with naphthylmethyl fragments at its three ends (). The protonation constants of all three polyamines show that at pH 6, all six primary and secondary nitrogen atoms in the arms are protonated. The interaction with Cu2+ and AMP (adenosine-5'-monophosphate) has been studied by potentiometric, UV-Vis, ESI-MS spectroscopy and NMR techniques. pH-Metric, NMR and ESI/MS techniques indicate that and form with AMP adducts of 1:1, 2:1 and 3:1 AMP:L stoichiometries in water. This is one of the first examples for the formation of such complexes in aqueous solution. Formation of ternary complexes between , , , Cu2+ and AMP is observed. Paramagnetic NMR techniques have been used to obtain structural information on the binding mode of AMP to the Cu2+- binuclear complexes.
authors.affiliation: Departament de Química Inorgànica, Institut de Ciència Molecular (ICMOL), Universitat de València, Edificio de Institutos de Paterna, Apartado de Correos 22085, 46071, Valencia, Spain.
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Albelda
authors.forename: Enrique
authors.initials: E
authors.lastname: García-España
authors.forename: Hermas R
authors.initials: HR
authors.lastname: Jiménez
authors.forename: José M
authors.initials: JM
authors.lastname: Llinares
authors.forename: Conxa
authors.initials: C
authors.lastname: Soriano
authors.forename: Alejandra
authors.initials: A
authors.lastname: Sornosa-Ten
authors.forename: Begoña
authors.initials: B
authors.lastname: Verdejo
mesh_terms: D000249:Adenosine Monophosphate / Q000737:chemistry*; D001665:Binding Sites; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry*; D011199:Potentiometry; D013057:Spectrum Analysis
chemical_list: D011073:Polyamines; D000249:Adenosine Monophosphate; D003300:Copper