Microscopic polyangiitis associated with primary biliary cirrhosis: a causal or casual association?
The association between microscopic polyangiitis (MPA) and primary biliary cirrhosis (PBC) has seldom been reported. We describe a patient with PBC and MPA who presented with polyarthritis and pulmonary nodules followed by pauci-immune crescentic glomerulonephritis and liver dysfunction. Detection of p-ANCA, antimyeloperoxidase, and antimitochondrial antibodies along with liver and renal histopathology allowed a diagnosis of MPA and PBC. We also discuss 2 other cases that could be unrecognized associations of both diseases. Further reports are necessary to clarify if the coexistence between PBC and MPA is causal or casual.
Amezcua-Guerra
Luis M
LM
Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan 14080, Mexico City, Mexico.
Prieto
Pilar
P
Bojalil
Rafael
R
Pineda
Carlos
C
Amigo
Mary-Carmen
MC
D001327:Autoimmune Diseases / Q000150:complications*; D005260:Female; D006801:Humans; D007673:Kidney Cortex Necrosis / Q000209:etiology; D007674:Kidney Diseases / Q000097:blood / Q000473:pathology*; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008171:Lung Diseases / Q000097:blood / Q000473:pathology*; D008875:Middle Aged; D014657:Vasculitis / Q000150:complications*