Risk of iron overload in carriers of genetic mutations associated with hereditary haemochromatosis: UK Food Standards Agency workshop.
The UK Food Standards Agency convened a group of expert scientists to review current research investigating diet and carriers of genetic mutations associated with hereditary haemochromatosis. The workshop concluded that individuals who are heterozygous for the C282Y mutation of the HFE gene do not appear to respond abnormally to dietary Fe and therefore do not need to change their diet to prevent accumulation of body Fe.
Singh
Mamta
M
Food Standards Agency, Aviation House, London WC2B 6NH, UK. mamta.singh@foodstandards.gsi.gov.uk
Ashwell
Margaret
M
Sanderson
Peter
P
Cade
Janet
J
Moreton
Jennifer
J
Fairweather-Tait
Susan
S
Roe
Mark
M
Marx
Joannes J M
JJ
Worwood
Mark
M
Cook
James D
JD
D050197:Atherosclerosis / Q000209:etiology; D004032:Diet; D020022:Genetic Predisposition to Disease; D006432:Hemochromatosis / Q000235:genetics; D000071020:Hemochromatosis Protein; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D019190:Iron Overload / Q000150:complications / Q000235:genetics*; D019266:Iron, Dietary / Q000493:pharmacokinetics; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation
C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D019266:Iron, Dietary; D008565:Membrane Proteins