[Effect of biologically active substances of animal and plant origin on prooxidant-antioxidant balance in rats with experimental prostatic hyperplasia].
The effect of biologically active complexes of animal (prostatilen) and plant (permixon) origin on physiological indices of prostate and prooxidant-antioxidant balance in prostate and blood was studied in rats with the hyperprolactinemia-induced prostatic hyperplasia. It was shown that both prostatilen (1 mg of the total peptides per kg) and permixon (100 mg of Serenoa repens extract per kg) prevent increase in the prostate mass and volume, in the content of lipid hydroperoxides, and in the glutathione peroxidase activity in prostate. Prostatilen, in contrast to permixon, normalized the content of lipid hydroperoxides (increased under hyperplazia conditions) and increases glutathione peroxidase activity (reduced under hyperplazia conditions).
Belostotskaia
L I
LI
Nikitchenko
Iu V
IuV
Gomon
O N
ON
Chaĭka
L A
LA
Bondar'
V V
VV
Dziuba
V N
VN
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000627:therapeutic use; D005979:Glutathione Peroxidase / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D016877:Oxidants / Q000378:metabolism*; D010455:Peptides / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D011467:Prostate / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D028024:Serenoa; D013469:Sulpiride
D000975:Antioxidants; D016877:Oxidants; D010455:Peptides; D010936:Plant Extracts; C069549:prostatilen; D013469:Sulpiride; D005979:Glutathione Peroxidase; C040972:saw palmetto extract