title: Ion conducting polymer microelectrodes for interfacing with neural networks.
abstract: We have examined the stimulation and recording properties of conjugated polymer microelectrode arrays as interfaces with neural networks of dissociated cortical cells. In particular the stimulation properties were investigated as a means of supplying a neural network with information. The stimulation efficiency at low stimulation voltages was evaluated and referenced to bare indium tin oxide (ITO) electrodes. The polymer electrodes were electrochemically polymerized from a blend of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT-PSS) and ethylenedioxythiophene (EDOT) onto ITO microelectrodes. Dissociated cortical cells were then plated on the electrodes and cultivated to form neural networks. Polymer electrode stimulation evoked a much greater response from the network than stimulation from ITO electrodes. Neural interfaces using polymer electrodes could be maintained for several months.
authors.affiliation: NTT Basic Research Laboratories, NTT Corporation, Atsugi, Kanagawa 243-0198, Japan. tobias.nyberg@sturetrading.com
authors.forename: Tobias
authors.initials: T
authors.lastname: Nyberg
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Shimada
authors.forename: Keiichi
authors.initials: K
authors.lastname: Torimitsu
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D004563:Electrochemistry; D004622:Embryo, Mammalian; D007150:Immunohistochemistry; D008839:Microelectrodes; D009415:Nerve Net / Q000502:physiology*; D016900:Neurofilament Proteins / Q000378:metabolism; D009474:Neurons / Q000502:physiology* / Q000528:radiation effects; D011108:Polymers; D051381:Rats; D013997:Time Factors
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D020099:Coated Materials, Biocompatible; D016900:Neurofilament Proteins; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene)