title: Use of voriconazole in a patient with aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus.
abstract: The case is reported of a patient with cavitary sarcoidosis complicated by an aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus, who was treated with voriconazole. The authors suggest that susceptibility testing of A. fumigatus strains is of value during long-term therapy with itraconazole, and that voriconazole may be a good option for treatment of patients infected with itraconazole-resistant strains of A. fumigatus.
authors.affiliation: Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie - Mycologie, 75015 Paris, France.|Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 75724 Paris Cedex 15, France.
authors.forename: E
authors.initials: E
authors.lastname: Dannaoui
authors.affiliation: Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 75724 Paris Cedex 15, France.
authors.forename: D
authors.initials: D
authors.lastname: Garcia-Hermoso
authors.affiliation: Service de Pneumologie, Hôpital Avicenne, 93009 Bobigny, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Naccache
authors.affiliation: Institute of Microbiology, University Hospital Lausanne, CH-1011 Lausanne, Switzerland.
authors.forename: I
authors.initials: I
authors.lastname: Meneau
authors.affiliation: Institute of Microbiology, University Hospital Lausanne, CH-1011 Lausanne, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Sanglard
authors.affiliation: Laboratoire de Parasitologie-Mycologie, Hôpital Avicenne, 93009 Bobigny, France.
authors.forename: C
authors.initials: C
authors.lastname: Bouges-Michel
authors.affiliation: Service de Pneumologie, Hôpital Avicenne, 93009 Bobigny, France.
authors.forename: D
authors.initials: D
authors.lastname: Valeyre
authors.affiliation: Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Necker-Enfants-Malades, Service des Maladies Infectieuses et Tropicales, 75743 Paris Cedex 15, France.|Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 75724 Paris Cedex 15, France.
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000187:drug effects*; D025141:Drug Resistance, Fungal; D006801:Humans; D006889:Hydroxycorticosteroids / Q000627:therapeutic use; D017964:Itraconazole / Q000494:pharmacology*; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D006889:Hydroxycorticosteroids; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D065819:Voriconazole