title: Spontaneous rapid osteolysis in Paget's disease after internal fixation of subtrochanteric femoral fracture.
abstract: Rapidly-progressive spontaneous progression of the osteolysis following internal fixation of pathological fracture in patients with Paget's disease has not been previously reported. We describe two patients, aged 59 and 65 years, respectively, who had pathological subtrochanteric fractures in Pagetic femora fixed internally using an interlocked intramedullary nail, and who developed spontaneous rapid osteolysis. Both patients responded favourably to long-term treatment with alendronate, with resultant fracture union and resolution of osteolysis.
authors.affiliation: Department of Orthopaedics and Spine Surgery, Ganga Hospital, Swarnambika Layout, Ramnagar, Coimbatore 641009, Tamil Nadu, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Khurjekar
authors.forename: S
authors.initials: S
authors.lastname: Vidyadhara
authors.forename: J
authors.initials: J
authors.lastname: Dheenadhayalan
authors.forename: S
authors.initials: S
authors.lastname: Rajasekaran
mesh_terms: D000368:Aged; D005260:Female; D005264:Femoral Fractures / Q000150:complications / Q000601:surgery*; D005593:Fracture Fixation, Internal / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000601:surgery*; D010014:Osteolysis; D013997:Time Factors