Serotypes, genotypes, and antibiotic susceptibility profiles of group B streptococci causing neonatal sepsis and meningitis before and after introduction of antibiotic prophylaxis.
We studied the characteristics of strains isolated from neonates with group B streptococci sepsis and meningitis, before and after the introduction of antibiotic prophylaxis in The Netherlands. In 1999, 1 year after this introduction the serotype and genotype distribution and the susceptibility patterns of the GBS strains had not changed. Penicillins remain drugs of first choice to prevent and treat neonatal GBS disease.
Trijbels-Smeulders
Monique A J M
MA
Department of Paediatrics, University Medical Centre (UMC ST Radboud), Nijmegen, The Netherlands. Trijbels@wxs.nl
Kimpen
Jan L L
JL
Kollée
Louis A A
LA
Bakkers
Judith
J
Melchers
Willem
W
Spanjaard
Lodewijk
L
Wannet
Wim J B
WJ
Hoogkamp-Korstanje
Mieke A A
MA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019072:Antibiotic Prophylaxis; D015373:Bacterial Typing Techniques; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000382:microbiology* / Q000517:prevention & control; D008826:Microbial Sensitivity Tests; D009426:Netherlands; D018805:Sepsis / Q000382:microbiology*; D012703:Serotyping; D013290:Streptococcal Infections / Q000382:microbiology* / Q000517:prevention & control; D013292:Streptococcus agalactiae / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents