Integrons containing the VIM-2 metallo-beta-lactamase gene among imipenem-resistant Pseudomonas aeruginosa strains from different Chinese hospitals.
A total of 140 nonrepetitive strains of imipenem-resistant Pseudomonas aeruginosa were isolated from five different Chinese hospitals. Fourteen isolates were confirmed to contain the VIM-2 metallo-beta-lactamase gene. Twelve isolates harbored two kinds of class 1 integron, containing both VIM-2- and aminoglycoside-resistant genes.
Yu
Yun-Song
YS
Infectious Disease Department, The 1st Affiliated Hospital, Medical School, Zhejiang University, The Key Laboratory of the Infectious Diseases of Public Health Ministry, Hangzhou, Zhejiang, China.
Qu
Ting-Ting
TT
Zhou
Jian-Ying
JY
Wang
Jie
J
Li
Hong-Yang
HY
Walsh
Timothy R
TR
D003227:Conjugation, Genetic; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D015378:Imipenem / Q000494:pharmacology*; D032023:Integrons; D016133:Polymerase Chain Reaction; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
D004251:DNA Transposable Elements; D015378:Imipenem; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases