title: [Immunoglobulin e and allergen-specific IgE antibodies in cosmonauts before and after long-duration missions on the International Space Station].
abstract: Immunoglobulins (IgG, IgA, IgM, IgE), specific IgE-antibodies, and interleukin-4 (IL-4) were investigated in blood serum of nine cosmonauts before and after 128- to 195-day ISS missions. It was shown that long-duration space flight does not change significantly the content of serum immunoglobulins, allergen-specific IgE-antibodies or IL-4. Analysis for probable ratios of the total IgE and IL-4 contents in the pre- and post-flight periods did not reveal any linear correlation of these parameters.
authors.forename: M P
authors.initials: MP
authors.lastname: Rykova
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Gertsik
authors.forename: E N
authors.initials: EN
authors.lastname: Antropova
authors.forename: L B
authors.initials: LB
authors.lastname: Buravkova
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D018480:Astronauts; D015415:Biomarkers / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology*; D015847:Interleukin-4 / Q000097:blood; D007391:International Cooperation; D013026:Space Flight; D018531:Spacecraft; D013997:Time Factors
chemical_list: D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D015847:Interleukin-4; D007073:Immunoglobulin E