title: Controlled release of chlorhexidine from UDMA-TEGDMA resin.
abstract: Chlorhexidine salts are available in various formulations for dental applications. This study tested the hypothesis that the release of chlorhexidine from a urethane dimethacrylate and triethylene glycol dimethacrylate resin system can be effectively controlled by the chlorhexidine diacetate content and pH. The filler concentrations were 9.1, 23.1, or 33.3 wt%, and the filled resins were exposed to pH 4 and pH 6 acetate buffers. The results showed that Fickian diffusion was the dominant release mechanism. The rates of release were significantly higher in pH 4 buffer, which was attributed to the increase of chlorhexidine diacetate solubility at lower pH. The higher level of filler loading reduced the degree of polymerization, leading to a greater loss of organic components and higher chlorhexidine release rates.
authors.affiliation: Department of Dental Biomaterials, College of Dentistry, University of Florida, PO Box 100446, 1600 SW Archer Road, Gainesville, FL 32610-0446, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Anusavice
authors.forename: N-Z
authors.initials: NZ
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Shen
mesh_terms: D002710:Chlorhexidine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D003188:Composite Resins / Q000737:chemistry / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics*; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D003188:Composite Resins; D003692:Delayed-Action Preparations; D011109:Polymethacrylic Acids; C080508:poly(triethylene glycol dimethacrylate-1,6-bis(methacryloxy-2-ethoxycarbonylamino)-2,4,4-trimethylhexane) copolymer; D011092:Polyethylene Glycols; D002710:Chlorhexidine