Plasmodium falciparum malaria associated with mefloquine failure in Gambia.
A 25-year-old Caucasian man developed Plasmodium falciparum malaria after traveling to Gambia, despite having received chemoprophylaxis with mefloquine. The patient was hospitalized after returning to the United States. He received a 3-day course of atovaquone-proguanil and made a complete recovery. This case illustrates the potential role of pharmacists in the pharmaceutical care of travelers and underscores the importance of using current recommendations for preventing and treating malaria.
Callen
Erin C
EC
Department of Pharmacy Practice, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, Oklahoma 73103, USA.
Church
Chelsea O
CO
D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D053626:Atovaquone / Q000627:therapeutic use; D018890:Chemoprevention; D005714:Gambia; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D015767:Mefloquine / Q000494:pharmacology / Q000627:therapeutic use*; D010963:Plasmodium falciparum; D002727:Proguanil / Q000627:therapeutic use; D018570:Risk Assessment; D012307:Risk Factors; D014195:Travel; D017211:Treatment Failure; D014481:United States
D000962:Antimalarials; D002727:Proguanil; D015767:Mefloquine; D053626:Atovaquone