title: On stochastic models of dynamic disorder.
abstract: In this paper we investigate some general aspects of stochastic models of dynamic disorder. First, we reexamine the Zwanzig model for the kinetics of escape through a fluctuating hole. We show that this model is trivially connected to the canonical model of the broadening of the zero-phonon line (ZPL) in crystals. This provides a new perspective of the Wang-Wolynes expression for the rate of escape from a geometric bottleneck with non-Markovian Gaussian fluctuations. Motivated by recent single-molecule experiments, we examine more general examples of fluctuation processes from the perspective of cumulant expansions. Finally, we discuss recent single-molecule experiments probing enzyme turnover performed by Xie and co-workers.
authors.affiliation: Department of Chemistry, Columbia University, 3000 Broadway, New York, New York, 10025, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Reichman
mesh_terms: D004798:Enzymes / Q000378:metabolism; D007700:Kinetics; D008956:Models, Chemical; D013269:Stochastic Processes
chemical_list: D004798:Enzymes