title: Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior.
abstract: Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines in the CA1 hippocampal pyramidal cells. Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior.
authors.affiliation: Center for Molecular and Human Genetics, Columbus Children's Research Institute, The Ohio State University, Columbus, OH 43205, USA. nishijii@pediatrics.ohio-state.edu
authors.forename: Ichiko
authors.initials: I
authors.lastname: Nishijima
authors.forename: Takanori
authors.initials: T
authors.lastname: Yamagata
authors.forename: Corinne M
authors.initials: CM
authors.lastname: Spencer
authors.forename: Edwin J
authors.initials: EJ
authors.lastname: Weeber
authors.forename: Olga
authors.initials: O
authors.lastname: Alekseyenko
authors.forename: J David
authors.initials: JD
authors.lastname: Sweatt
authors.forename: Mariko Y
authors.initials: MY
authors.lastname: Momoi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ito
authors.forename: Dawna L
authors.initials: DL
authors.lastname: Armstrong
authors.forename: David L
authors.initials: DL
authors.lastname: Nelson
authors.forename: Richard
authors.initials: R
authors.lastname: Paylor
authors.forename: Allan
authors.initials: A
authors.lastname: Bradley
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D003214:Conditioning, Classical; D049229:Dendritic Spines; D004594:Electrophysiology; D005239:Fear; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008568:Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D009048:Motor Skills; D009473:Neuronal Plasticity; D043562:Receptors, G-Protein-Coupled / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D011964:Receptors, Gastrointestinal Hormone / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D012633:Secretin / Q000502:physiology; D015398:Signal Transduction; D012919:Social Behavior
chemical_list: D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone; C029937:secretin receptor; D012633:Secretin