Preconditioning: the mitochondrial connection.
Over the past decade there has been considerable progress in elucidating the signaling pathways involved in cardioprotection. Considerable recent data suggest that many of these signaling pathways converge on the mitochondria, where such pathways alter the activity of key mitochondrial proteins, leading to reduced apoptosis and necrosis. Inhibition of the mitochondrial permeability transition pore is emerging as a central mechanism in cardioprotection. This review focuses on mechanisms by which cardioprotection alters mitochondrial proteins and channels that regulate cell death and survival.
Murphy
Elizabeth
E
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. murphy1@niehs.nih.gov
Steenbergen
Charles
C
D000818:Animals; D016923:Cell Death / Q000235:genetics / Q000502:physiology; D038341:Glycogen Synthase Kinases / Q000378:metabolism; D006331:Heart Diseases / Q000517:prevention & control; D006801:Humans; D019194:Ischemic Preconditioning; D008929:Mitochondria, Heart / Q000235:genetics / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000502:physiology; D010539:Permeability; D015221:Potassium Channels / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D024101:Mitochondrial Proteins; D015221:Potassium Channels; D038341:Glycogen Synthase Kinases