From systems biology to dynamical neuropharmacology: proposal for a new methodology.
The concepts and methods of systems biology are extended to neuropharmacology in order to test and design drugs for the treatment of neurological and psychiatric disorders. Computational modelling by integrating compartmental neural modelling techniques and detailed kinetic descriptions of pharmacological modulation of transmitter-receptor interaction is offered as a method to test the electrophysiological and behavioural effects of putative drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realise a prescribed temporal pattern. In particular, as an application of the proposed new methodology, a computational platform is offered to analyse the generation and pharmacological modulation of theta rhythm related to anxiety.
Erdi
P
P
Center for Complex Systems Studies, Kalamazoo College, Kalamazoo, Michigan, USA. perdi@kzoo.edu
Kiss
T
T
Tóth
J
J
Ujfalussy
B
B
Zalányi
L
L
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003198:Computer Simulation; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008959:Models, Neurological; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009480:Neuropharmacology / Q000379:methods*; D018377:Neurotransmitter Agents / Q000008:administration & dosage* / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012107:Research Design; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D049490:Systems Biology / Q000379:methods*
D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter