title: The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in children.
abstract: OBJECTIVE
  To determine the efficacy of prophylactic administration of zinc sulphate in reducing the occurrence of the common cold in children, and to evaluate the efficacy of zinc sulphate in reducing the duration and severity of cold symptoms.
  
  
  METHODS
  A total of 200 healthy children were randomly assigned to receive oral zinc sulphate (zinc group, n=100) or placebo (placebo group, n=100). Zinc sulphate (15 mg of zinc) or placebo syrup were administered for prophylaxis once daily during a 7-mo study period. The dose was increased to two times per day (30 mg of zinc) at the onset of cold, until symptoms resolved.
  
  
  RESULTS
  The mean number of colds in the zinc group was significantly less than in the placebo group (1.2 vs 1.7 colds per child; p=0.003). The mean cold-related school absence was 0.9 d per child in the zinc group versus 1.3 d in the placebo group (p=0.04). Compared to the placebo group, the zinc group had shorter mean duration of cold symptoms and decreased total severity scores for cold symptoms (p<0.0001). Adverse effects were mild and similar in both groups.
  
  
  CONCLUSIONS
  Zinc sulphate appears to be an easily administered, safe and well-tolerated alternative for the prevention and treatment of the common cold in children.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Ege University, Izmir, Turkey. kurugol@med.ege.edu.tr
authors.forename: Zafer
authors.initials: Z
authors.lastname: Kurugöl
authors.forename: Münevver
authors.initials: M
authors.lastname: Akilli
authors.forename: Nuri
authors.initials: N
authors.lastname: Bayram
authors.forename: Guldane
authors.initials: G
authors.lastname: Koturoglu
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003139:Common Cold / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome; D019287:Zinc Sulfate / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D019287:Zinc Sulfate