[SP-selectin and beta-TG as serum markers of platelet activation in menopausal women with depression].
During activation, blood platelets (PLT) release a number of micromolecular compounds, of which P-selectin and beta-thromboglobulin (beta-TG) are considered the major markers of the activation. The activated platelets and the released micromolecular compounds actively participate in thromboembolic disorders frequently observed in menopause. Low estrogen level in menopausal women is a common cause of depressive disorders. The aim of the study was to compare the state of PLT activation in menopausal women with and without depression. The assessment of PLT activation was based on the concentration of sP-selectin and beta-TG as serum markers of the activation.


METHODS
Among 65 menopausal women examined, 16 (approx. 25%) had depression. PLT activation was assessed on the basis of sP-selectin and beta-TG levels. The investigation was performed in the low-platelet citrate serum obtained from venous blood collected onto anticoagulant. The levels of beta-TG and sP-selectin were determined using the immunoenzymatic method, with ELISA Kit reagents.


RESULTS
In all the women, both with and without depression, the levels of beta-TG and sP-selectin several times exceeded the accepted norms. The concentration of beta-TG was statistically significantly higher (p < 0.05) in women with depression as compared to those with no depressive disorders.


CONCLUSIONS
Menopausal women suffering from depression show enhanced intravascular platelet activation. High beta-TG level in women with depression indicates higher risk of thromboembolic disorders in comparison with depression-free women in menopause.
Mantur
Maria
M
Akademia Medyczna w Białymstoku, Zakład Laboratoryjnej Diagnostyki Klinicznej. mantur@amb.edu.pl
Tomczak
Anna Agnieszka
AA
Chrzanowski
Włodzimierz
W
Juchnowicz
Dariusz
D
Borowiec
Magdalena
M
D000328:Adult; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology* / Q000523:psychology*; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism*; D001620:beta-Thromboglobulin / Q000378:metabolism*
D019007:P-Selectin; D001620:beta-Thromboglobulin