Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa.
We report myocardial injury in 20 recombinant factor VIIa (rFVIIa) treated and 110 nontreated patients with intracerebral hemorrhage. Patients were treated or received standard medical management. All received EKG and cardiac enzyme testing. Elevated troponin occurred in 20% treated vs 3% nontreated (p = 0.02). Myocardial infarction occurred in 10% vs 1% (p = 0.01). We found a significant increase in myocardial injury in rFVIIa treated patients.
Sugg
R M
RM
Department of Neurology, The University of Houston Medical School, Houston, TX 77030, USA.
Gonzales
N R
NR
Matherne
D E
DE
Ribo
M
M
Shaltoni
H M
HM
Baraniuk
S
S
Noser
E A
EA
Grotta
J C
JC
D000368:Aged; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000401:mortality; D004562:Electrocardiography / Q000379:methods; D005167:Factor VII / Q000009:adverse effects*; D015942:Factor VIIa; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced*; D011994:Recombinant Proteins / Q000009:adverse effects; D013997:Time Factors; D014336:Troponin / Q000378:metabolism
D011994:Recombinant Proteins; D014336:Troponin; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa