title: Chemokines in multiple myeloma.
abstract: OBJECTIVE
  In this article we focus on the role that chemokines and chemokine receptors play in the pathogenesis of multiple myeloma and the associated bone destructive process, and consider their utility as novel therapeutic targets for treating this devastating disease.
  
  
  METHODS
  Current research on the role that chemokine and chemokine receptors play in the pathogenesis of myeloma is reviewed.
  
  
  RESULTS
  The chemokines, MIP-1alpha, MCP-1, IL-8, and SDF-1, and their receptors play important roles in homing of MM cells, tumor growth, and bone destruction in myeloma. They are attractive therapeutic targets for treating myeloma patients.
  
  
  CONCLUSIONS
  Addition of chemokine antagonists to current treatment regimens for myeloma should result in better therapeutic responses because of the loss of both the protective effect of the marrow microenvironment on the MM cells and the induction of osteoclast activity.
authors.affiliation: Department of Internal Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA.
authors.forename: Rohit
authors.initials: R
authors.lastname: Aggarwal
authors.forename: Irene M
authors.initials: IM
authors.lastname: Ghobrial
authors.forename: G David
authors.initials: GD
authors.lastname: Roodman
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D001859:Bone Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D002454:Cell Differentiation; D002465:Cell Movement; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology; D019707:Receptors, Chemokine / Q000378:metabolism*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine