Effects of Erigeron injection on vascular endothelium in patients after intracoronary stenting.
OBJECTIVE
To observe the levels of serum C-reactive protein (CRP), endothelin-1 (ET-1), nitric oxide (NO), and superoxide dismutase (SOD) in patients after intracoronary stenting (ICS), and the effects of Erigeron Injection (EI) on them.


METHODS
Seventy-two patients, who received ICS and had symptoms of chest stuffiness, palpitation and chest pain, were randomly divided into two groups, with 36 patients in the control group treated with Plavix alone for anti-platelet aggregation, and the other 36 patients in the treated group treated with Plavix and EI in combination. CRP, ET-1, NO and SOD were determined and compared before and 1, 2 and 3 weeks after treatment.


RESULTS
As compared with those in the control group, improvement of symptoms in the treated group was significantly better, with the levels of CRP and ET-1 lower and levels of SOD and NO higher or approaching to normal ranges and significant difference was shown between the two groups (P < 0.01).


CONCLUSIONS
EI could alleviate uncomfortable feelings such as chest stuffiness in patients after ICS, and improve the function of vascular endothelium.
Wang
Xiao-ying
XY
Hospital of Zhejiang University, Hangzhou, China.
Miao
Feng
F
D002097:C-Reactive Protein / Q000378:metabolism; D000077144:Clopidogrel; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects*; D049919:Erigeron; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D015607:Stents; D013482:Superoxide Dismutase / Q000097:blood; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives
D019332:Endothelin-1; D028321:Plant Preparations; D010975:Platelet Aggregation Inhibitors; D009569:Nitric Oxide; D002097:C-Reactive Protein; D000077144:Clopidogrel; D013482:Superoxide Dismutase; D013988:Ticlopidine