title: Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa.
abstract: We report myocardial injury in 20 recombinant factor VIIa (rFVIIa) treated and 110 nontreated patients with intracerebral hemorrhage. Patients were treated or received standard medical management. All received EKG and cardiac enzyme testing. Elevated troponin occurred in 20% treated vs 3% nontreated (p = 0.02). Myocardial infarction occurred in 10% vs 1% (p = 0.01). We found a significant increase in myocardial injury in rFVIIa treated patients.
authors.affiliation: Department of Neurology, The University of Houston Medical School, Houston, TX 77030, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Sugg
authors.forename: N R
authors.initials: NR
authors.lastname: Gonzales
authors.forename: D E
authors.initials: DE
authors.lastname: Matherne
authors.forename: M
authors.initials: M
authors.lastname: Ribo
authors.forename: H M
authors.initials: HM
authors.lastname: Shaltoni
authors.forename: S
authors.initials: S
authors.lastname: Baraniuk
authors.forename: E A
authors.initials: EA
authors.lastname: Noser
authors.forename: J C
authors.initials: JC
authors.lastname: Grotta
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000401:mortality; D004562:Electrocardiography / Q000379:methods; D005167:Factor VII / Q000009:adverse effects*; D015942:Factor VIIa; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced*; D011994:Recombinant Proteins / Q000009:adverse effects; D013997:Time Factors; D014336:Troponin / Q000378:metabolism
chemical_list: D011994:Recombinant Proteins; D014336:Troponin; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa