title: [The main pharmacokinetic parameters of p-tyrosol upon intravenous injection in rats. II. Verification of the pharmacokinetics linearity and evaluation of the possible accumulation].
abstract: The main pharmacokinetic parameters of p-tyrosol after single (in 3 doses) and repeated intravenous injection were studied in rats. The content ofp-tyrosol in the blood plasma was determined by spectrofluorimetric method. The pharmacokinetic parameters of p-tyrosol are linear in the dose range from 50 to 200 mg/kg. Repeated administration leads to accelerated metabolic elimination of p-tyrosol.
authors.forename: G A
authors.initials: GA
authors.lastname: Chernysheva
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.forename: V I
authors.initials: VI
authors.lastname: Smol'iakova
authors.forename: I V
authors.initials: IV
authors.lastname: Cherkashina
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: A P
authors.initials: AP
authors.lastname: Krysin
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol