title: Intrastromal diathermal keratostomy: a new micropenetrating clear-cornea glaucoma procedure.
abstract: OBJECTIVE
  The filtering intrastromal diathermal keratostomy (IDK) was developed to comply with the call for a low postoperative intraocular pressure (IOP) and a bleb morphology without a thin, cystic appearance.
  
  
  METHODS
  A diathermal microkeratostomy (150 to 200 microm) was created into the anterior chamber, anterior to the Schwalbe line through the floor of a surgical corneoscleral tunnel incision into the subconjunctival space. A newly developed, bipolar diathermal microneedle was used to create the keratostomy, replacing the Holmium laser used previously. Subconjunctival injections of 3 microg mitomycin C were used in each eye 1 week before the IDK to obtain maximum antiproliferative effect at the time of the operation. Nine patients (10 eyes) with complicated, refractory primary and secondary open-angle glaucoma are discussed.
  
  
  RESULTS
  Histologic examination of the IDK and clinical postoperative ultrasound biomicroscopy showed an optimal appearance of the diathermal microkeratostomy. After 34 months (range 24 to 42 mo) the mean IOP was 11 mm Hg (SD+/-3, range 6 to 16) without medication in all 10 eyes. IDK revision with internal needling of postoperative subconjunctival fibrosis through the tunnel incision was performed in 5 eyes after an average of 3 months (range 0.2 to 7 mo). After 33 months (range 19 to 38 mo), the postrevision mean IOP was 10 mm Hg (SD+/-2, range 8 to 14) without medication in all 5 eyes. All 10 eyes showed noncystic diffuse blebs with optimal spongy subepithelial morphology: in 2 eyes the blebs were totally avascular and in 8 eyes they were relatively avascular.
  
  
  CONCLUSIONS
  The preliminary results of the new clear-cornea IDK seem promising because of postoperative IOP of about 10 mm Hg despite a low dose of mitomycin C and noncystic bleb morphology.
authors.affiliation: Glaucoma Clinic, Eye Clinic, Copenhagen University Hospital, Rigshospitalet, Denmark. svend.kessing@dadlnet.dk
authors.forename: Svend V
authors.initials: SV
authors.lastname: Kessing
authors.forename: Steffen
authors.initials: S
authors.lastname: Heegaard
authors.forename: Ole I
authors.initials: OI
authors.lastname: Nissen
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D003319:Corneal Stroma / Q000000981:diagnostic imaging / Q000187:drug effects / Q000601:surgery*; D004564:Electrocoagulation / Q000379:methods*; D018463:Filtering Surgery / Q000379:methods*; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D033401:Microscopy, Acoustic; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D012086:Reoperation; D013524:Surgical Flaps
chemical_list: D016685:Mitomycin