The mTOR pathway in the control of protein synthesis.
Signaling through mammalian target of rapamycin (mTOR) is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.
Wang
Xuemin
X
Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Proud
Christopher G
CG
D000818:Animals; D002468:Cell Physiological Phenomena; D006801:Humans; D014176:Protein Biosynthesis; D011494:Protein Kinases / Q000378:metabolism / Q000502:physiology*; D012270:Ribosomes; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases
D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases