title: Standardization of an experimental murine model of invasive pulmonary aspergillosis.
abstract: Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.
authors.affiliation: McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada. donald.sheppard@mcgill.ca
authors.forename: Donald C
authors.initials: DC
authors.lastname: Sheppard
authors.forename: John R
authors.initials: JR
authors.lastname: Graybill
authors.forename: Laura K
authors.initials: LK
authors.lastname: Najvar
authors.forename: Lisa Y
authors.initials: LY
authors.lastname: Chiang
authors.forename: Thomas
authors.initials: T
authors.lastname: Doedt
authors.forename: William R
authors.initials: WR
authors.lastname: Kirkpatrick
authors.forename: Rosie
authors.initials: R
authors.lastname: Bocanegra
authors.forename: Ana C
authors.initials: AC
authors.lastname: Vallor
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Patterson
authors.forename: Scott G
authors.initials: SG
authors.lastname: Filler
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D001232:Aspergillus fumigatus / Q000302:isolation & purification / Q000472:pathogenicity*; D004195:Disease Models, Animal; D006801:Humans; D008081:Liposomes; D008168:Lung / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D051379:Mice; D015203:Reproducibility of Results; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B