Avascular necrosis of the femoral head: vascular hypotheses.
Vascular hypotheses provide compelling pathogenic mechanisms for the etiology of avascular necrosis of the femoral head (ANFH). A decrease in local blood flow of the femoral head has been postulated to be the cause of the disease. Several studies in human and animal models of ANFH have shown microvascular thrombosis. Endothelial cell damage could be followed by abnormal blood coagulation and thrombus formation with any resulting degeneration distal to the site of vascular occlusion. Other studies suggest that thrombophilia, particularly impaired fibrinolysis, plays a potential role in thrombus formation in ANFH. Reduction in shear stress due to decreased blood flow could lead to apoptosis of endothelial cells, which can ultimately contribute to plaque erosion and thrombus formation. Dysregulation of endothelial cell activating factors and stimulators of angiogenesis or repair processes could also affect the progression and outcome of ANFH. Likewise, regional endothelium dysfunction (RED), referred to as a potential defect in endothelial cells located in the feeding vessels of the femoral head itself, may also have a crucial role in the pathogenesis of ANFH. Molecular gene analysis of regional endothelial cells could also help to determine potential pathways important in the pathogenesis of ANFH.
Kerachian
Mohammad Amin
MA
Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Harvey
Edward J
EJ
Cournoyer
Denis
D
Chow
Terry Y K
TY
Séguin
Chantal
C
D004730:Endothelium, Vascular / Q000503:physiopathology*; D005270:Femur Head / Q000098:blood supply*; D005271:Femur Head Necrosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D013927:Thrombosis / Q000503:physiopathology