title: Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer.
abstract: It is well established that cancers affect differentiation of dendritic cells and promote systemic expansion of immune suppressive immature myeloid cells. This phenomenon may represent a mechanism of tumor escape from immune attack and could have significant impact on tumor progression. In this review we discuss the role of different tumor-derived factors, which were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed.
authors.affiliation: H. Lee Moffitt Cancer Center, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA. kusmars@moffitt.usf.edu
authors.forename: Sergei
authors.initials: S
authors.lastname: Kusmartsev
authors.forename: Dmitry I
authors.initials: DI
authors.lastname: Gabrilovich
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D053612:Janus Kinases / Q000502:physiology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D022423:Myeloid Cells / Q000166:cytology* / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D050791:STAT Transcription Factors / Q000502:physiology; D019139:Tumor Escape
chemical_list: D016207:Cytokines; D050791:STAT Transcription Factors; D053612:Janus Kinases