HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.
BACKGROUND
A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS).


METHODS
We have genotyped the HLA-B alleles in 56 Caucasian patients with varying severities of CBZ hypersensitivity and 43 controls on CBZ without adverse effects.


RESULTS
None of our patients (including two with blistering skin rashes) were positive for the HLA-B*1502 allele. HLA-B*0702 allele may protect against severe CBZ hypersensitivity but warrants further study. Of secondary interest, the correlation between HLA-B*0801 and HLA-DR3, DQ2 and TNF -308 alleles (on the ancestral haplotype 8.1) is consistent with our previous findings.


CONCLUSIONS
HLA-B*1502 does not seem to be a marker for all forms of CBZ-induced hypersensitivity in a Caucasian population.
Alfirevic
Ana
A
Department of Pharmacology & Therapeutics, The University of Liverpool, Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
Jorgensen
Andrea L
AL
Williamson
Paula R
PR
Chadwick
David W
DW
Park
B Kevin
BK
Pirmohamed
Munir
M
D000483:Alleles; D044466:Asian People / Q000235:genetics; D002220:Carbamazepine / Q000009:adverse effects*; D016022:Case-Control Studies; D004342:Drug Hypersensitivity / Q000235:genetics* / Q000276:immunology*; D005787:Gene Frequency; D005819:Genetic Markers; D015235:HLA-B Antigens / Q000235:genetics*; D059910:HLA-B15 Antigen; D015793:HLA-B7 Antigen; D015795:HLA-B8 Antigen; D006683:HLA-DQ Antigens / Q000235:genetics; D015803:HLA-DR3 Antigen / Q000235:genetics; D006801:Humans; D043922:Toxicogenetics; D006113:United Kingdom; D044465:White People / Q000235:genetics
D005819:Genetic Markers; D015235:HLA-B Antigens; C477444:HLA-B*07:02 antigen; C509422:HLA-B*08:01 antigen; C483536:HLA-B*15:02 antigen; D059910:HLA-B15 Antigen; D015793:HLA-B7 Antigen; D015795:HLA-B8 Antigen; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; D015803:HLA-DR3 Antigen; D002220:Carbamazepine