title: Serum prolidase activity and oxidative status in Helicobacter pylori infection.
abstract: OBJECTIVE
  During the course of Helicobacter pylori infection, increased oxidative stress plays an important role in the pathogenesis of gastroduodenal mucosal inflammation, which can cause gastric mucosal atrophy that characterized by the replacement of the gastric mucosal glands by collagen fibers. In the present study, we aimed to determine serum prolidase activity and oxidative status, and to find out if there is any association between serum prolidase activity and oxidative status in H. pylori infection.
  
  
  METHODS
  Forty H. pylori-positive and 32 H. pylori-negative subjects were enrolled. Serum prolidase activity was measured spectrophotometrically. Oxidative status was determined using total antioxidant capacity and total oxidant status measurement and calculation of oxidative stress index.
  
  
  RESULTS
  Total antioxidant capacity level was lower in H. pylori-positive group than H. pylori-negative group (p<0.001), whereas total oxidant status, oxidative stress index and prolidase activity were higher (all p<0.05). Significant correlation was observed between serum prolidase activity, and total antioxidant capacity, total oxidant status and oxidative stress index (p<0.01, r=-0.367; p<0.05, r=0.283; p<0.01, r=0.379; respectively) in H. pylori-positive subjects.
  
  
  CONCLUSIONS
  H. pylori infection may be associated with increased oxidative stress and increased serum prolidase activity. Increased oxidative stress seems to be associated with increased serum prolidase activity and this association may help to provide a better understanding about the pathogenesis of H. pylori infection.
authors.affiliation: Harran University, School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey. m.aslan301@mynet.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Yasar
authors.initials: Y
authors.lastname: Nazligul
authors.forename: Mehmet
authors.initials: M
authors.lastname: Horoz
authors.forename: Cengiz
authors.initials: C
authors.lastname: Bolukbas
authors.forename: Fusun F
authors.initials: FF
authors.lastname: Bolukbas
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000328:Adult; D003710:Demography; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000201:enzymology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction
chemical_list: D004150:Dipeptidases; C022449:proline dipeptidase