title: Determination of daunomycin at a novel COOH/indium tin oxide ion implantation-modified electrode.
abstract: A novel COOH+ ion implantation-modified indium tin oxide (COOH/ITO) electrode was prepared for the first time and applied for determination of daunomycin (or daunorubicin [DNR]). The electrode showed higher catalytic activity than bare ITO electrode with good reproducibility and stability. The determination condition of linear voltammetry was optimized. A calibration curve was obtained over the range 2.0 x 10(-7) to 5.0 x 10(-6)mol/L, with a correlation coefficient of 0.9909 and a limit of detection of 1.0 x 10(-7)mol/L. The selectivity of the electrode was illustrated by determination of DNR in samples prepared of urine. X-ray photoelectron spectroscopy (XPS) analysis results showed that the implanted COOH+ maintained characteristics of organic group -COOH. A field emission-scanning electron microscope (FSEM) result showed that the implanted surface caused defects and partial dislocations and formed many active centers.
authors.affiliation: Department of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: DongMei
authors.initials: D
authors.lastname: Gao
authors.forename: JingBo
authors.initials: J
authors.lastname: Hu
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.forename: QiLong
authors.initials: Q
authors.lastname: Li
mesh_terms: D003630:Daunorubicin / Q000032:analysis*; D004355:Drug Stability; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D007477:Ions; D008855:Microscopy, Electron, Scanning; D015203:Reproducibility of Results; D017971:Tin Compounds
chemical_list: D007477:Ions; D017971:Tin Compounds; C109984:indium tin oxide; D003630:Daunorubicin