[Excessive body weight and coexisting with it changes in levels of hormones of adrenal and gonadal origin are associated with coronary artery disease in men].
The aim of study was to estimate relation between excessive body weight (EBW) and coronary artery disease (CAD) in men and to assess changes in concentrations of hormones due to EBW which may predispose to atherogenesis.


METHODS
Study group (CADM) - 33 men in the age 52 +/- 6 years, with body mass index (BMI) above 25 kg/m2 and angiographically documented CAD. Comparative group (CM) - 13 men in the same age without CAD. Apart from evaluation of occurence of risk factors in men of both groups concentrations of hormones in blood were assessed: insulin, insulin-like growth factor I, estradiol (E2), testosterone (T), dehydroepiandrosterone sulfate (DHEAS), follicle-stimulating hormone, luteinizing hormone, progesterone (Prog), cortisol (Cort) and leptin (Lept).


RESULTS
In CADM, comparing to CM, greater values of parameters related to EBW, BMI (30,0 +/- 2,6 vs. 26,8 +/- 2,6 kg/m2, p<0,0007) and waist-hip ratio (WHR 1,07 +/- 0,04 vs. 0,92 +/- 0,03, p<0,000001), higher concentrations of Prog (3,0 +/- 1,3 vs. 1,4 +/- 0,9 nmol/l, p<0,0003), Kort (350 +/- 108 vs. 246 +/- 97nmol/l, p<0,006) and Lept (18,2 +/- 10,5 vs. 8,0 +/- 3,6 lU/l, p<0,0003) and lower of T (9,9 +/- 4,0 vs. 12,3 +/- 3,2 nmol/l, p<0,046) were found. In regression analysis coexistence of EBW and eleveted level of Prog revealed the best fit with presence of CAD. Positive correlation between EBW and concentration of Lept and E2 and negative correlation between EBW and concentrations of T, Cort and DHEAS in CADM were found.


CONCLUSIONS
EBW is a highly aggravating risk factor of CAD in men and is linked to proatherogenic changes in levels of steroid hormones of adrenal and gonadal origin.
Sablik
Zbigniew
Z
Uniwersytet Medyczny w LodziKlinika Kardiologii I Katedry Kardiologii i Kardiochirurgii. zbyszek.lek1@poczta.fm
Samborska-Sablik
Anna
A
Goch
Jan Henryk
JH
Kula
Krzysztof
K
D000305:Adrenal Cortex Hormones / Q000097:blood*; D000311:Adrenal Glands / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006066:Gonads / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D012739:Gonadal Steroid Hormones