title: Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice.
abstract: A nasal formulation of mometasone furoate (MF) is advantageous in avoiding systemic activity characteristic of glucocorticoids when it is applied topically. To confirm antiallergic effects of this glucocorticoid formulation elaborately, we investigated whether the drug can suppress the production of IgE antibodies and related cytokines. It we showed that IgE production induced in mice immunized via intranasal route was significantly reduced when the mice were administered MF intranasally. Further, MF was effective in inhibiting production of type-2 helper T cell cytokines in vivo and in vitro. These results provide a immunopharmacological basis for clinical efficacy of this drug.
authors.affiliation: Department of Bioscience and Biotechnology, Okayama University, Okayama, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Magari
authors.forename: Mika
authors.initials: M
authors.lastname: Ikeda
authors.forename: Miki
authors.initials: M
authors.lastname: Asakura
authors.forename: Naoki
authors.initials: N
authors.lastname: Kanayama
authors.forename: Masami
authors.initials: M
authors.lastname: Ogawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohmori
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D002460:Cell Line; D004342:Drug Hypersensitivity / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D007114:Immunization / Q000379:methods; D007073:Immunoglobulin E / Q000276:immunology* / Q000378:metabolism; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism; D007279:Injections, Subcutaneous; D015847:Interleukin-4 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D000068656:Mometasone Furoate; D009574:Nitro Compounds / Q000008:administration & dosage / Q000276:immunology; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D011244:Pregnadienediols / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D007074:Immunoglobulin G; D009574:Nitro Compounds; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D015847:Interleukin-4; D007073:Immunoglobulin E; D010047:Ovalbumin