title: A substantial part of the fallopian tube is left after standard prophylactic bilateral salpingo-oophorectomy.
abstract: Women with a deleterious germline mutation in BRCA1 or BRCA2 are candidates for bilateral salpingo-oophorectomy (BSO). To address the need for adjustment of the current BSO procedure, we investigated the length and the nature of the fallopian tube epithelium that is not removed by BSO. Fourteen consecutive hysterectomy specimens were collected. Complete cross-sections with a 3-mm interval were made of the tubal lumen from the outside of the uterus at the cutoff point of the current BSO procedure to the uterine cavity and examined for the presence or absence of tubal type (ciliated) epithelium and subepithelial endometrial stroma. The fallopian tube remnant had a median length of 12 mm (range 6-15 mm). Tubal type (ciliated) epithelium was shown to be present in all uteri in the first cross-section containing 100% endometrial stroma, as well as in the uterine cavity of all but two of the hysterectomy specimens. A substantial part of the fallopian tube remains in situ after prophylactic BSO and is covered with tubal type ciliated epithelium. More research is necessary to investigate the role of this remnant part of the tube for BRCA carriers.
authors.affiliation: Department of Obstetrics & Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: L H M
authors.initials: LH
authors.lastname: Gerritzen
authors.forename: J M M
authors.initials: JM
authors.lastname: Grefte
authors.forename: N
authors.initials: N
authors.lastname: Hoogerbrugge
authors.forename: J
authors.initials: J
authors.lastname: Bulten
authors.forename: L F A G
authors.initials: LF
authors.lastname: Massuger
authors.forename: J A
authors.initials: JA
authors.lastname: de Hullu
mesh_terms: D000328:Adult; D004847:Epithelial Cells / Q000166:cytology; D005185:Fallopian Tube Neoplasms / Q000517:prevention & control*; D005187:Fallopian Tubes / Q000166:cytology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000517:prevention & control; D010052:Ovariectomy / Q000379:methods*