title: Observations on intrauterine oxygen tension measured by fibre-optic microsensors.
abstract: Understanding the biology of reproductive organs is essential for the development of assisted reproductive techniques. There is at present no direct evidence for either the concentration and dynamics of intrauterine oxygen tension at the endometrial surface, nor its importance for the receptiveness of the endometrium. In this study a new method measured mid-cycle (ranging from day 12-18) endometrial surface oxygen tension in 21 patients referred to intrauterine insemination (IUI). Time series was measured online for a period of 5-10 min. The (mean) individual oxygen tension among patients varied from 4 to 27% air saturation. Overall mean oxygen tension among all patients was 11.8% air saturation. Within the same patient, considerable time-related variations were observed. Some patients exhibited rhythmic oscillations with a frequency in the order of 1 min, whereas others did not show any regular patterns. A good description of endometrial surface oxygen concentration and dynamics was thus obtained, but given the relatively small number of participants, an association with pregnancy following insemination could not be established. Further studies using this new method could elucidate the association between individual intrauterine activity, embryo implantation and endometrial surface oxygen tension.
authors.affiliation: The Fertility Clinic, Department of Obstetrics and Gynaecology, Aarhus University Hospital Skejby Sygehus, Brendstrupgaardsvej, DK-8200 Aarhus N, Denmark. Lars.ottosen@ki.au.dk
authors.forename: Lars D M
authors.initials: LD
authors.lastname: Ottosen
authors.forename: Johnny
authors.initials: J
authors.lastname: Hindkaer
authors.forename: Merete
authors.initials: M
authors.lastname: Husth
authors.forename: Dorrit Elschner
authors.initials: DE
authors.lastname: Petersen
authors.forename: John
authors.initials: J
authors.lastname: Kirk
authors.forename: Hans Jakob
authors.initials: HJ
authors.lastname: Ingerslev
mesh_terms: D000328:Adult; D005260:Female; D005336:Fiber Optic Technology / Q000379:methods*; D006801:Humans; D007315:Insemination, Artificial; D010100:Oxygen / Q000502:physiology*; D014599:Uterus / Q000378:metabolism*
chemical_list: D010100:Oxygen