title: Heritability of plasma amino acid levels in different nutritional states.
abstract: Significant heritability has been shown for several plasma amino acid levels, but the results may have been confounded by sampling in a variety of nutritional states. We studied a group of families on a low protein steady-state diet in fasting and non-fasting states. Heritability of individual amino acids varied according to the nutritional state, suggesting the amount of genetic and environmental influences differ among the operative systems that control individual amino acid homeostasis throughout the feed/fast cycle.
authors.affiliation: Center for Molecular and Human Genetics, Columbus Children's Research Institute, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA. mcbridek@ccri.net
authors.forename: Kim L
authors.initials: KL
authors.lastname: McBride
authors.forename: John W
authors.initials: JW
authors.lastname: Belmont
authors.forename: William E
authors.initials: WE
authors.lastname: O'Brien
authors.forename: Tanay J
authors.initials: TJ
authors.lastname: Amin
authors.forename: Susan
authors.initials: S
authors.lastname: Carter
authors.forename: Brendan H
authors.initials: BH
authors.lastname: Lee
mesh_terms: D000596:Amino Acids / Q000097:blood*; D016022:Case-Control Studies; D003677:Deficiency Diseases / Q000178:diet therapy / Q000235:genetics; D018753:Diet, Protein-Restricted; D005190:Family; D005215:Fasting; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D009752:Nutritional Status / Q000235:genetics*; D040641:Quantitative Trait Loci; D012016:Reference Values
chemical_list: D000596:Amino Acids