title: [Antigen-antibody reaction model of solid-phase surface and active biochip system].
abstract: To overcome the present limitations of passive biochip, based on the basic principle of antigen-antibody reaction, we develop an antigen-antibody reaction model of solid-phase surface and design a novel active biochip system according to this model, which introduces the negative pressure and controlling devices to control the immunoreactions on the nitrocellulose (NC) membrane. From the computer simulation results, this is a rapid, stable, robust and practicable system, which can be used to increase the efficiency of immunoreactions and improve the reproducibility and accuracy of biochip analysis.
authors.affiliation: Institute of Genetic Diagnosis, The Fourth Military Medical University, Xi'an 710032, China. zhuwenwei428@hotmail.com
authors.forename: Wenwei
authors.initials: W
authors.lastname: Zhu
authors.forename: Wenhong
authors.initials: W
authors.lastname: Zhang
authors.forename: Wenbiao
authors.initials: W
authors.lastname: Zhu
authors.forename: Fengchan
authors.initials: F
authors.lastname: Han
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Dong
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Yan
mesh_terms: D000937:Antigen-Antibody Reactions; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D008954:Models, Biological