Monostotic fibrous dysplasia of the proximal femur and liposclerosing myxofibrous tumor: which one is which?
Clinical, histological, and genetic studies of two cases of isolated fibro-osseous lesions of the femur in adults show the overlap between monostotic fibrous dysplasia (MFD) of the proximal femur and the so-called liposclerosing myxofibrous tumor. The two cases highlight how the incomplete understanding of the natural history of MFD may result in diagnostic pitfalls or incorrect classification of individual lesions.
Corsi
Alessandro
A
Dipartimento de Medicina Sperimentale e Patologia, Università La Sapienza, Rome, Italy.
De Maio
Fernando
F
Ippolito
Ernesto
E
Cherman
Natasha
N
Gehron Robey
Pamela
P
Riminucci
Mara
M
Bianco
Paolo
P
D000328:Adult; D002864:Chromogranins; D003937:Diagnosis, Differential; D005260:Female; D005266:Femoral Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D005272:Femur Neck / Q000473:pathology / Q000601:surgery; D005350:Fibroma / Q000145:classification / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D005358:Fibrous Dysplasia, Monostotic / Q000145:classification / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D012598:Sclerosis
D002864:Chromogranins; C406732:GNAS protein, human; D019205:GTP-Binding Protein alpha Subunits, Gs