Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines.
A series of chloro-fluorine containing chalcones (3) were prepared by Claisen-Schmidt condensation. Chalcone dibromides (4) were obtained by the bromination of chalcones at room temperature. Treatment of chalcone dibromides (4) with aryloxy acid hydrazides (5) in the presence of triethylamine gave chloro-fluorine containing hydroxy pyrazolines (7) rather than the expected 1-aryloxy-3-aryl-5-aryl pyrazoles (6). The structures of the newly synthesized compounds were confirmed by IR, NMR, mass and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities. Some compounds showed very good antibacterial activity and antifungal activity.
Karthikeyan
Mari Sithambaram
MS
Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore, Karnataka 574199, India. karthims02@rediffmail.com <karthims02@rediffmail.com>
Holla
Bantwal Shivarama
BS
Kumari
Nalilu Suchetha
NS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047188:Chalcones / Q000737:chemistry; D015169:Colony Count, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D003904:Mitosporic Fungi / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047188:Chalcones; D011720:Pyrazoles