Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's disease.
We have recently demonstrated that apolipoprotein E (APOE)-varepsilon4 allele is a risk factor for Alzheimer disease (AD) in Tehran, Iran. The current study specifically aimed to examine whether APOE polymorphism in association with serum lipids-apolipoprotein level is a risk factor for AD in a population from Tehran, Iran. APOE polymorphism and plasma lipids, apoA1, apoB and lipoprotein (a) (Lp(a)) levels were determined in 94 AD patients and 111matched controls. Our study demonstrated a significant association between APOE polymorphism and the level of plasma lipids and apolipoprotein with AD in this population. The AD subjects had significantly lower apoA1 (p<0.001) and HDL-C (p<0.01) and higher apoB (p=0.01) and LDL-C (p=0.02) levels than that of the control group. The AD subjects carrying APOE-varepsilon4 allele had lower plasma apoA1 (t=5.2, p<0.002) and HDL-C level (t=2.7, p=0.01) but had higher plasma apoB (t=-5.4, p<0.002), LDL-C (t=-4.6, p=0.005) and total cholesterol (TC) (t=-2.7, p=0.01) than that of the non APOE-varepsilon4 carriers. These results indicated that AD patients with APOE-varepsilon4 allele has a distinct plasma lipid profile and carrier of this allele with low levels of apoA1 and HDL-C may be more susceptible to AD.
Raygani
Asad Vaisi
AV
Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Daneshgah Avenue, P.O. Box 67148, 69914 Kermanshah, Iran. vaisira@yahoo.com
Rahimi
Zohreh
Z
Kharazi
Hadi
H
Tavilani
Haidar
H
Pourmotabbed
Tayebeh
T
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000378:metabolism*; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007492:Iran; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
D001057:Apolipoproteins E; D008055:Lipids