Hormonal activity of AIMP1/p43 for glucose homeostasis.
AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic alpha cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.
Park
Sang Gyu
SG
National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Kang
Young Sun
YS
Kim
Jin Young
JY
Lee
Chang Seok
CS
Ko
Young Gyu
YG
Lee
Woo Je
WJ
Lee
Ki-Up
KU
Yeom
Young Il
YI
Kim
Sunghoon
S
D041721:3T3-L1 Cells; D000818:Animals; D016207:Cytokines / Q000172:deficiency / Q000378:metabolism*; D020869:Gene Expression Profiling; D005934:Glucagon / Q000097:blood; D050416:Glucagon-Secreting Cells / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D005947:Glucose / Q000378:metabolism*; D050261:Glycogenolysis / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D007003:Hypoglycemia; D008066:Lipolysis / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D021381:Protein Transport
C514492:Aimp1 protein, mouse; D016207:Cytokines; D005934:Glucagon; D005947:Glucose