title: Pancreatic endocrine tumor with partial acinar cell differentiation.
abstract: We examined a 70-year-old woman in whom a pancreatic endocrine tumor with partial acinar cell differentiation had been diagnosed. She had neither endocrine nor exocrine symptoms. The tumor was located in the pancreatic tail and measured 12.5 x 9.5 x 8 cm. It had a capsule, was composed of multiple adhesion nodules, and was elastically soft, medullary, and yellowish white. The neoplastic cells had large, irregular, oval nuclei; prominent eosinophilic nucleoli; and abundant eosinophilic cytoplasm with many fine granules. The cells had proliferated in islet-like solid medullary, trabecular, acinar, and papillary patterns. Most neoplastic cells were strongly positive for synaptophysin. 10 to 25% of the neoplastic cells were positive for alpha1-antitrypsin. Neuroendocrine and zymogen granules were simultaneously observed in the cytoplasm of the same neoplastic cells at the ultrastructural level. The tumor may be considered an amphicrine tumor.
authors.affiliation: Internal Medicine, Prefecture Medical Graduate School of Medical Sciences, Kyoto, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Minakawa
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Oka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nihei
authors.forename: Norimasa
authors.initials: N
authors.lastname: Sando
authors.forename: Haruna
authors.initials: H
authors.lastname: Oikawa
authors.forename: Joe
authors.initials: J
authors.lastname: Toda
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Akio
authors.initials: A
authors.lastname: Yanagisawa
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D001707:Biopsy, Needle; D018267:Carcinoma, Acinar Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D018273:Carcinoma, Islet Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D022142:Secretory Vesicles / Q000648:ultrastructure; D016708:Synaptophysin / Q000032:analysis / Q000378:metabolism; D014463:Ultrasonography; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D016708:Synaptophysin; D000515:alpha 1-Antitrypsin