title: Prognostic value of initial magnetic resonance imaging growth rates for World Health Organization grade II gliomas.
abstract: A consecutive series of 143 unselected adult patients with histologically proved World Health Organization grade II gliomas was reviewed to assess the prognostic value of growth rates of mean tumor diameters on successive magnetic resonance images before treatment. There is an inverse correlation between growth rates and survival (p < 0.001; median survival at 5.16 years for a growth rate of 8mm/year or more; median survival >15.0 years for a growth rate <8mm/year). Thus, individual magnetic resonance imaging tumor growth rates should be incorporated in the planning of the initial therapeutic strategy of grade II gliomas.
authors.affiliation: Service de Neurochirurgie, Hôpital de la Pitié-Salpêtrière, Paris, France.
authors.forename: Johan
authors.initials: J
authors.lastname: Pallud
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mandonnet
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.forename: Michèle
authors.initials: M
authors.lastname: Kujas
authors.forename: Rémy
authors.initials: R
authors.lastname: Guillevin
authors.forename: Damien
authors.initials: D
authors.lastname: Galanaud
authors.forename: Luc
authors.initials: L
authors.lastname: Taillandier
authors.forename: Laurent
authors.initials: L
authors.lastname: Capelle
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013223:Statistics as Topic; D016019:Survival Analysis; D014944:World Health Organization
chemical_list: D019394:Ki-67 Antigen