title: Hospital admissions for acute painful crisis in Trinidad and Tobago. Are the British Committee for Standards in Haematology (BCSH) guidelines applicable?
abstract: We observed consecutive hospital admissions for acute painful crisis (APC) among adults with Sickle Cell Disease (SCD) over a 6-month period in Trinidad and Tobago. Episodes (111) of APC resulted in 82 admissions of 59 patients. The most common site for pain was the trunk. Patients ranged in age from 17 to 53 years (median: 25). Median length of hospital stay was 4 days. Total dose of Pethidine given per admission ranged from 100 to 1650 mg (median: 525). The mean dose of morphine was 70 mg. Six (7%) of patients were readmitted within 10 days of discharge. Twenty-five (30%) of patients had chest pain at presentation of whom 10 (12%) had consolidation on chest X-ray, defining the acute chest syndrome (ACS). There was one death caused by biliary sepsis. The study revealed seemingly low opiate usage for in-hospital treatment of APC with acceptable rates of readmission. The BCSH 2003 guidelines seemed applicable apart for the choice and route of fluid for rehydration and opiate analgesia.
authors.affiliation: Haematology Department, General Hospital, Charlotte Street, Port of Spain, Trinidad and Tobago. skcharles58@hotmail.com
authors.forename: K S
authors.initials: KS
authors.lastname: Charles
authors.forename: K
authors.initials: K
authors.lastname: Osagie
authors.forename: R K
authors.initials: RK
authors.lastname: Battini
mesh_terms: D000293:Adolescent; D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000755:Anemia, Sickle Cell / Q000150:complications / Q000188:drug therapy*; D005260:Female; D019983:Guideline Adherence; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008614:Meperidine / Q000627:therapeutic use*; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010359:Patient Readmission / Q000706:statistics & numerical data; D017410:Practice Guidelines as Topic / Q000592:standards; D012189:Retrospective Studies; D016896:Treatment Outcome; D014300:Trinidad and Tobago
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine; D008614:Meperidine