Mapping of the Plasmodium chabaudi resistance locus char2.
Animals congenic for the char2 host response locus to the murine malarial parasite Plasmodium chabaudi have been bred, and they demonstrated a phenotypic difference from the parental lines. These congenic lines have been crossed back to the parental line to generate recombinants across the congenic intervals. The recombinants were inbred, and the subcongenic intervals were fixed. These lines were then challenged with parasites and assessed as being either resistant or susceptible. From the analysis of many subcongenic lines, it has become obvious that there are at least two loci underlying the char2 locus and that both of these mediate resistance when the haplotype derives from the resistant C57BL/6 strain.
Lin
Enmoore
E
Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Parkville, Victoria 3050, Australia.
Pappenfuss
Tony
T
Tan
Rachel B
RB
Senyschyn
Danielle
D
Bahlo
Melanie
M
Speed
Terence P
TP
Foote
Simon J
SJ
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D008040:Genetic Linkage; D008288:Malaria / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D016788:Plasmodium chabaudi; D019655:Quantitative Trait, Heritable