Regulation of alpha-chymotrypsin activity on the surface of substrate-functionalized gold nanoparticles.
A gold nanoparticle functionalized with substrates for alpha-chymotrypsin was fabricated to afford an enzyme modulator that exhibited enzyme-specific activation coupled with general inhibition of other proteases.
You
Chang-Cheng
CC
Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Arvizo
Rochelle R
RR
Rotello
Vincent M
VM
D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006046:Gold; D053758:Nanoparticles; D009842:Oligopeptides / Q000494:pharmacology
D009842:Oligopeptides; C015516:succinyl-trialanine-4-nitroanilide; D006046:Gold; D002918:Chymotrypsin; C117608:alpha-chymotrypsin