title: Dopaminergic resistant prolactinomas in the peripubertal population.
abstract: We report two children with macroadenomas and hyperprolactinemia resistant to medical therapy using dopamine agonists, who experienced secondary pituitary dysfunction. Both required surgical debulking, and one has received growth hormone treatment with no increase in tumor size.
authors.affiliation: Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children and University of Toronto, Ontario, Canada.
authors.forename: Carol
authors.initials: C
authors.lastname: Huang
authors.forename: Shereen
authors.initials: S
authors.lastname: Ezzat
authors.forename: Sylvia L
authors.initials: SL
authors.lastname: Asa
authors.forename: Jill
authors.initials: J
authors.lastname: Hamilton
mesh_terms: D000236:Adenoma / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D000293:Adolescent; D002648:Child; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D010911:Pituitary Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D011627:Puberty / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists