title: New rifabutin analogs: synthesis and biological activity against Mycobacterium tuberculosis.
abstract: The synthesis, structure, and biological evaluation of a series of novel rifamycin derivatives, Rifastures (RFA) with potent anti-tuberculosis activity are presented. Some of these derivatives showed higher in vitro activity than rifabutin and rifampicin against not only Mycobacterium tuberculosis strains but also against MAC and Mycobacterium kansasii.
authors.affiliation: Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al CSIC, Universidad de Oviedo, C/ Julián Clavería, 8, 33006 Oviedo, Spain. barluenga@uniovi.es
authors.forename: José
authors.initials: J
authors.lastname: Barluenga
authors.forename: Fernando
authors.initials: F
authors.lastname: Aznar
authors.forename: Ana-Belén
authors.initials: AB
authors.lastname: García
authors.forename: María-Paz
authors.initials: MP
authors.lastname: Cabal
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Palacios
authors.forename: María-Angela
authors.initials: MA
authors.lastname: Menéndez
mesh_terms: D000904:Antibiotics, Antitubercular / Q000138:chemical synthesis / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D019909:Mycobacterium kansasii / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D017828:Rifabutin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology
chemical_list: D000904:Antibiotics, Antitubercular; D017828:Rifabutin; D012293:Rifampin