title: [Preliminary approach towards construction of peptide libraries as potential tools for diagnosis of malignant thyroid tumors].
abstract: BACKGROUND
  Cancer of thyroid gland is the most common malignancy of the endocrine system. The treatment improvement could be achieved by early diagnosis. The aim of the study was to identify cancer specific antigenes with use of peptide libraries.
  
  
  METHODS
  The material from 6 patients with thyroid cancer (4 with papillary cancer, 1 with follicular cancer and 1 with oxyphilic tumor) were analyzed. It was performed with use of lipophylic peptide libraries by direct comparison of staining of specimens prepared from normal and malignant tissue.
  
  
  RESULTS
  Preliminary results confirm practical value of peptide libraries in early diagnostics of thyroid cancer.
  
  
  CONCLUSIONS
  It is important to optimize construction of peptide libraries by using different staining agents hydrolyzed by proteases.
authors.affiliation: 1st Department of General, Gastroenterological and Endocrinological Surgery, Medical University, Wroclaw. wbalcerzak@wp.pl
authors.forename: Waldemar
authors.initials: W
authors.lastname: Balcerzak
authors.forename: Wiktor
authors.initials: W
authors.lastname: Bednarz
authors.forename: Paweł
authors.initials: P
authors.lastname: Domosławski
authors.forename: Robert
authors.initials: R
authors.lastname: Olewiński
authors.forename: Justyna
authors.initials: J
authors.lastname: Kolesińska
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Kaminski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Dziarkowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Wieczorek
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000737:chemistry / Q000473:pathology*; D018249:Adenoma, Oxyphilic / Q000737:chemistry / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D018265:Carcinoma, Papillary, Follicular / Q000737:chemistry / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D037502:Galectin 3 / Q000032:analysis; D006801:Humans; D007453:Iodide Peroxidase / Q000032:analysis; D008297:Male; D009361:Neoplasm Invasiveness; D019151:Peptide Library; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013194:Staining and Labeling / Q000379:methods; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D037502:Galectin 3; D019151:Peptide Library; D007453:Iodide Peroxidase