title: Influence of aging on adrenal responsiveness in a population of eleven healthy beagles.
abstract: The present study aimed at investigating the effects of aging on the adrenal cortex response of cortisol and aldosterone in dogs. A population of healthy adult Beagles was evaluated twice at a five-year interval. At each evaluation, plasma basal cortisol and aldosterone, cortisol and aldosterone following ACTH-stimulation, sodium, and potassium concentrations and arterial blood pressure were measured. We observed significantly (p<0.05) greater sodium, urea and creatinine concentrations with aging. Nevertheless urea and creatinine remained within our laboratory reference ranges. This study showed a highly significant age-related elevation of basal cortisol (p<0.01). Inversely, both aldosterone following ACTH-stimulation levels and difference between aldosterone following ACTH-stimulation and basal aldosterone values plummeted significantly (p<0.01) with aging. In conclusion, the evaluation of the adrenal cortex function in dogs should take in consideration the age of the individuals.
authors.affiliation: SIAMU, Small Animal Sciences Department, Ecole Nationale Vétérinaire de Lyon, 1, avenue Bourgelat, 69280 Marcy l'Etoile, UMR-MA 103, France. i.goy-thollot@vet-lyon.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Goy-Thollot
authors.forename: Christelle
authors.initials: C
authors.lastname: Decosne-Junot
authors.forename: Jeanne-Marie
authors.initials: JM
authors.lastname: Bonnet
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000375:Aging / Q000097:blood / Q000502:physiology*; D000450:Aldosterone / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003404:Creatinine / Q000097:blood; D004285:Dogs / Q000097:blood / Q000502:physiology*; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood / Q000494:pharmacology; D014508:Urea / Q000097:blood
chemical_list: D000450:Aldosterone; D014508:Urea; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D006854:Hydrocortisone