QRAR models for cardiovascular system drugs using biopartitioning micellar chromatography.
The capability of biopartitioning micellar chromatography (BMC) to describe and estimate pharmacological parameters of cardiovascular system drugs has been studied. The retention of cardiovascular system drugs was studied using different pH of Brij-35 as micellar mobile phase in modified C(18) stationary phase. Quantitative retention-activity relationships (QRAR) in BMC were investigated for these compounds. An adequate correlation between the retention factors (log k) and the toxicity (LD(50)) of cardiovascular system drugs was obtained.
Wang
Sumin
S
College of Pharmacy, Hebei University, Baoding 071002, China; Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China.
Yang
Gengliang
G
Zhang
Hua
H
Liu
Haiyan
H
Li
Zhiwei
Z
D002317:Cardiovascular Agents / Q000032:analysis* / Q000633:toxicity; D002853:Chromatography, Liquid / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007928:Lethal Dose 50; D021281:Quantitative Structure-Activity Relationship; D012015:Reference Standards
D002317:Cardiovascular Agents