A paranasal tumor associated with tumor-induced osteomalacia.
BACKGROUND
Tumor-induced osteomalacia (TIO) is an extremely rare paraneoplastic syndrome associated with mesenchymal tumors in the craniofacial region.


METHODS
We treated a 24-year-old Japanese woman with paranasal sinus tumor and a low serum phosphate level who presented with nasal obstruction and systemic bone fractures. Serum fibroblast growth factor 23 (FGF-23) was measured before and after surgery.


RESULTS
After surgery, her symptoms were resolved and the serum phosphate and FGF-23 levels became normalized.


CONCLUSIONS
FGF-23 is thought to be a useful diagnostic marker in patients with craniofacial tumors associated with multiple systemic fractures.
Inokuchi
Go
G
Department of Otorhinolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Tanimoto
Hitoshi
H
Ishida
Haruhiko
H
Sugimoto
Toshitsugu
T
Yamauchi
Mika
M
Miyauchi
Akimitsu
A
Nibu
Ken-Ichi
K
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D015519:Bone Density / Q000502:physiology; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D008637:Mesenchymoma / Q000150:complications* / Q000601:surgery; D015508:Nasal Obstruction / Q000209:etiology; D010018:Osteomalacia / Q000209:etiology*; D010255:Paranasal Sinus Neoplasms / Q000150:complications* / Q000601:surgery; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010710:Phosphates / Q000097:blood
D014408:Biomarkers, Tumor; C000717427:FGF23 protein, human; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D000469:Alkaline Phosphatase