title: Can patients with McArdle's disease run?
abstract: Patients with McArdle's disease commonly adopt a sedentary lifestyle. This sedentary behaviour, however, usually worsens the limited exercise capacity of these patients. Although eccentric muscle work can be associated with rhabdomyolysis, supervised eccentric training with gradually increasing loads has important advantages compared with conventional concentric work, particularly for patients with a poor cardiorespiratory system. We report the beneficial effects (particularly, increased VO(2peak) (from 14.6 to 30.8 ml/kg/min) and increased gross muscle efficiency (from 13.8% to 17.2%)) induced by a supervised aerobic training programme of 7 months duration including 3-4 running sessions (< or =60 min/session) per week in a 38-year-old patient. These preliminary data suggest the potential therapeutic value of this type of exercise in these patients.
authors.affiliation: Universidad Europea de Madrid, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Moran
authors.forename: C
authors.initials: C
authors.lastname: Cardona
authors.forename: J L
authors.initials: JL
authors.lastname: Maté-Muñoz
authors.forename: J C
authors.initials: JC
authors.lastname: Rubio
authors.forename: A L
authors.initials: AL
authors.lastname: Andreu
authors.forename: M A
authors.initials: MA
authors.lastname: Martin
authors.forename: J
authors.initials: J
authors.lastname: Arenas
authors.forename: A
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D005081:Exercise Therapy / Q000379:methods*; D006012:Glycogen Storage Disease Type V / Q000503:physiopathology / Q000628:therapy*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D012420:Running / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D003402:Creatine Kinase