title: Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease.
abstract: Familial cold autoinflammatory syndrome (FCAS) is a rare, hereditary disorder characterized by cold-induced inflammation. We describe the successful longterm treatment of a patient with FCAS with anakinra, an interleukin 1 receptor antagonist (IL-1Ra). The remarkable response of FCAS and associated Raynaud's disease in this patient suggests that IL-1 is an important mediator of these inflammatory diseases. Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases.
authors.affiliation: Division of Rheumatology, University of Southern California, Los Angeles, California 90033, USA. metyas@usc.edu
authors.forename: Samy K
authors.initials: SK
authors.lastname: Metyas
authors.forename: Hal M
authors.initials: HM
authors.lastname: Hoffman
mesh_terms: D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D007375:Interleukin-1 / Q000502:physiology; D008875:Middle Aged; D011928:Raynaud Disease / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control*; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D013577:Syndrome; D014581:Urticaria / Q000503:physiopathology / Q000517:prevention & control; D014652:Vascular Diseases / Q000235:genetics / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1