Active defense under oxidative stress. The antioxidant responsive element.
This review considers the mechanisms and factors that stimulate transcription of genes regulated by the antioxidant responsive element (ARE). The latter is important for cell defense under conditions of oxidative stress and also for detoxification of electrophilic xenobiotics. There are differences in regulation of intracellular homeostasis involving Nrf2-mediated activation of ARE and other redox-sensitive factors (NF-kappaB and AP-1).
Lyakhovich
V V
VV
Institute of Molecular Biology and Biophysics, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk 630117, Russia.
Vavilin
V A
VA
Zenkov
N K
NK
Menshchikova
E B
EB
D000818:Animals; D000975:Antioxidants / Q000502:physiology*; D005786:Gene Expression Regulation; D054477:Glutaredoxins; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D017879:Isothiocyanates / Q000494:pharmacology; D000072019:Kelch-Like ECH-Associated Protein 1; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000502:physiology; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000378:metabolism; D010544:Peroxidases / Q000378:metabolism; D054464:Peroxiredoxins; D010636:Phenols / Q000494:pharmacology; D011809:Quinones / Q000494:pharmacology; D020218:Response Elements / Q000502:physiology*; D013879:Thioredoxins / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000187:drug effects*; D015262:Xenobiotics / Q000378:metabolism
D000975:Antioxidants; D054477:Glutaredoxins; D047908:Intracellular Signaling Peptides and Proteins; D017879:Isothiocyanates; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; D010636:Phenols; D011809:Quinones; D014157:Transcription Factors; D015262:Xenobiotics; D013879:Thioredoxins; D010088:Oxidoreductases; D010544:Peroxidases; D054464:Peroxiredoxins; D016660:NAD(P)H Dehydrogenase (Quinone); D005982:Glutathione Transferase