Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups--precursors to a variety of alpha-CF3-alpha-amino acid derivatives.
Convenient routes to methyl 2-oxalylimino- and 2-(phosphonoformimido)-3,3,3-trifluoropropanoates have been elaborated, based on the reaction of methyl trifluoropyruvate with ethyl oxamate or diethyl carbamoylphosphonate, respectively, followed by dehydration. The compounds obtained are useful synthetic intermediates toward a variety of novel 3,3,3-trifluoroalanine derivatives that are potential drug candidates.
Skarpos
Hanna
H
Institute for Inorganic and Physical Chemistry, The University of Bremen, Leobener Str., D-28334, Germany.
Vorob'eva
Daria V
DV
Osipov
Sergey N
SN
Odinets
Irina L
IL
Breuer
Eli
E
Röschenthaler
Gerd-Volker
GV
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004583:Electrons; D007097:Imines / Q000737:chemistry*; D019289:Pyruvic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*
D000596:Amino Acids; D007097:Imines; D019289:Pyruvic Acid