title: Treatment of facial angiofibroma of tuberous sclerosis using cultured epithelial autografts.
abstract: Treatment of facial angiofibroma of tuberous sclerosis is problematic, because the skin lesions involve entire dermis. Five patients aged from 14 to 33 (mean: 23.6) years old with angiofibroma of tuberous sclerosis were treated with cultured epithelial autografts between 1995 and 2004. The entire area of the facial lesions was excised using a razor to remove large nodules, and then the remaining lesions were further abraded to a rather deep layer of the dermis to smooth the skin and remove small nodules. Then a cultured autologous epithelium was grafted onto the wound. In all patients, epithelization was complete within 10 (mean: 9) days after the surgery. All patients were followed up for more than 6 months and showed neither depigmentation due to scar formation nor hypertrophic scars. In some patients, some pebbly regrowth had occurred at 5 years postoperatively, but the appearance was quite acceptable.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan. keijiro@prs.twmu.ac.jp
authors.forename: Keijiro
authors.initials: K
authors.lastname: Hori
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Soejima
authors.forename: Motohiro
authors.initials: M
authors.lastname: Nozaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakurai
authors.forename: Masaki
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamaki
authors.forename: Susumu
authors.initials: S
authors.lastname: Iwasaka
authors.forename: Taro
authors.initials: T
authors.lastname: Kono
authors.forename: Takashi
authors.initials: T
authors.lastname: Honda
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Isago
mesh_terms: D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000209:etiology / Q000601:surgery*; D004848:Epithelium / Q000637:transplantation*; D005153:Facial Neoplasms / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D046509:Tissue Culture Techniques; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications*