Highly diastereoselective preparation of anti-1,2-diols by catalytic addition of alkynylsilanes to alpha-silyloxyaldehydes.
The catalytic, diastereoselective coupling of alpha-silyloxy aldehydes and alkynylsilanes catalyzed by a nickel(0) N-heterocyclic carbene complex provides an effective entry to anti-1,2-diols. The scope of couplings and extent of diastereoselection are excellent across a range of substrates.
Sa-ei
Kanicha
K
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Montgomery
John
J
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D012821:Silanes