Asymmetric hydrogenation with antibody-achiral rhodium complex.
Monoclonal antibodies have been elicited against an achiral rhodium complex and this complex was used in the presence of a resultant antibody, 1G8, for the catalytic hydrogenation of 2-acetamidoacrylic acid to produce N-acetyl-L-alanine in high (>98%) enantiomeric excess.
Yamaguchi
Hiroyasu
H
Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
Hirano
Tohko
T
Kiminami
Hideaki
H
Taura
Daisuke
D
Harada
Akira
A
D000596:Amino Acids / Q000737:chemistry; D000906:Antibodies / Q000737:chemistry*; D002384:Catalysis; D006241:Haptens / Q000737:chemistry; D006865:Hydrogenation; D012238:Rhodium / Q000737:chemistry*
D000596:Amino Acids; D000906:Antibodies; D006241:Haptens; D012238:Rhodium