title: Enantio- and diastereoselective hydrogenation via dynamic kinetic resolution by a cationic iridium complex in the synthesis of beta-hydroxy-alpha-amino acid esters.
abstract: Anti-selective asymmetric hydrogenation of alpha-amino-beta-keto esters via dynamic kinetic resolution under low hydrogen pressure has been achieved by an easily-handled cationic iridium complex with tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (BARF) as a counterion.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Kazuishi
authors.initials: K
authors.lastname: Makino
authors.forename: Masamichi
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Hamada
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002412:Cations; D004952:Esters; D006859:Hydrogen / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D007700:Kinetics; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002412:Cations; D004952:Esters; D007495:Iridium; D006859:Hydrogen