Angiotensin converting enzyme inhibitors and aortic arch obstructive malformations.
We describe two newborn infants with aortic arch obstructive malformations who became anuric after initiation of captopril. Since angiotensin converting enzyme inhibitors can alter renal blood flow by reduction in angiotensin II and blocking autoregulation phenomenon, it is important to use them with great caution in neonates with aortic arch obstructive malformations, while monitoring their renal function closely.
Maliheh
Kadivar
K
Department of Neonatology, Tehran University of Medical Sciences, Children's Medical Center, Tehran, Iran.
Abdorrazagh
Kiani
K
Armen
Kocharian
K
Reza
Shabanian
S
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D001017:Aortic Coarctation / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002216:Captopril / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D014463:Ultrasonography
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril