Mini review: immune response to myelin-derived sulfatide and CNS-demyelination.
Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on the recognition of the self-glycolipid sulfatide by a distinct population of non-invariant NK T cells. The results of studies we have obtained so far in investigating the presentation of sulfatide by CNS-resident cells including microglia and their interactions with T cells indicate that this pathway might be successfully targeted for the treatment of autoimmune demyelination in multiple sclerosis.
Halder
Ramesh C
RC
Laboratory of Autoimmunity, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA.
Jahng
A
A
Maricic
I
I
Kumar
Vipin
V
D000818:Animals; D018949:Antigens, CD1 / Q000502:physiology; D020278:Demyelinating Autoimmune Diseases, CNS / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D005699:Galactosylceramides / Q000276:immunology; D006017:Glycolipids / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology; D013433:Sulfoglycosphingolipids / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D018949:Antigens, CD1; D005699:Galactosylceramides; D006017:Glycolipids; D013433:Sulfoglycosphingolipids; C493154:alpha-galactosylceramide