title: Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.
abstract: PPAR ligands with varied subtype selectivity have been synthesized using an achiral aminomethyl dihydrocinnamate template. Several compounds in this series have demonstrated potent plasma glucose and triglyceride lowering capability in rodent models of type 2 diabetes.
authors.affiliation: Eli Lilly and Co, Indianapolis, IN 46285, USA. amw@lilly.com
authors.forename: Alan M
authors.initials: AM
authors.lastname: Warshawsky
authors.forename: Charles A
authors.initials: CA
authors.lastname: Alt
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Brozinick
authors.forename: Allen R
authors.initials: AR
authors.lastname: Harkness
authors.forename: Eric D
authors.initials: ED
authors.lastname: Hawkins
authors.forename: James R
authors.initials: JR
authors.lastname: Henry
authors.forename: Donald P
authors.initials: DP
authors.lastname: Matthews
authors.forename: Anne R
authors.initials: AR
authors.lastname: Miller
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Misener
authors.forename: Chahrzad
authors.initials: C
authors.lastname: Montrose-Rafizadeh
authors.forename: Gary A
authors.initials: GA
authors.lastname: Rhodes
authors.forename: Quanrong
authors.initials: Q
authors.lastname: Shen
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Vance
authors.forename: Uko E
authors.initials: UE
authors.lastname: Udodong
authors.forename: Minmin
authors.initials: M
authors.lastname: Wang
authors.forename: Tony Y
authors.initials: TY
authors.lastname: Zhang
authors.forename: Richard W
authors.initials: RW
authors.lastname: Zink
mesh_terms: D002934:Cinnamates / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008024:Ligands; D047493:PPAR alpha / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology*; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000627:therapeutic use
chemical_list: D002934:Cinnamates; D007004:Hypoglycemic Agents; D008024:Ligands; D047493:PPAR alpha; D047495:PPAR gamma; D047492:Peroxisome Proliferator-Activated Receptors; D045162:Thiazolidinediones