title: Assessment of regional left ventricular function with multidetector-row computed tomography versus magnetic resonance imaging.
abstract: This study compares quantitative and qualitative information on global and regional left ventricular (LV) function obtained with multidetector-row computed tomography (MDCT) with that obtained with magnetic resonance imaging (MRI) in patients with a high prevalence of LV wall motion abnormalities. Thirty patients (19 male, 63.7+/-15.1 years) with myocardial infarction (n=12), coronary artery disease (n=9), arrhythmogenic right ventricular cardiomyopathy (n=6), and dilation cardiomyopathy (n=3) were included. Segmental LV wall motion (LV-WM) was assessed using a 4-point scale. Wall thickness measurements were calculated in diastolic and systolic short axis images. Two hundred and fifty-two out of 266 (94.7%) normal and 189 out of 214 (88.3%) segments with decreased wall motion were correctly identified by MDCT, yielding a sensitivity of 88% and specificity of 95% for identification of wall motion abnormalities. LV-WM scores were identical in 86.7% of 480 segments (kappa=0.809). MDCT had a tendency to underestimate the degree of wall motion impairment. Interobserver agreement was lower in MDCT (66.5%) than in MRI (89.1%; p<0.01). Normokinetic segments are reliably identified with MDCT. Sensitivity for detection and accurate classification of LV wall motion abnormalities need to be improved. Better temporal resolution of the CT system seems to be the most important factor for enhancing MDCT performance.
authors.affiliation: Department of Clinical Radiology, University of Münster, Albert-Schweitzer-Strasse 33, 48149, Münster, Germany.
authors.forename: Roman
authors.initials: R
authors.lastname: Fischbach
authors.forename: Kai Uwe
authors.initials: KU
authors.lastname: Juergens
authors.forename: Murat
authors.initials: M
authors.lastname: Ozgun
authors.forename: David
authors.initials: D
authors.lastname: Maintz
authors.forename: Matthias
authors.initials: M
authors.lastname: Grude
authors.forename: Harald
authors.initials: H
authors.lastname: Seifarth
authors.forename: Walter
authors.initials: W
authors.lastname: Heindel
authors.forename: Thomas
authors.initials: T
authors.lastname: Wichter
mesh_terms: D000319:Adrenergic beta-Antagonists; D009202:Cardiomyopathies / Q000175:diagnosis*; D003324:Coronary Artery Disease / Q000175:diagnosis*; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D015588:Observer Variation; D014057:Tomography, X-Ray Computed; D016277:Ventricular Function, Left
chemical_list: D000319:Adrenergic beta-Antagonists