Characterization of chondroitin sulfate and its interpenetrating polymer network hydrogels for sustained-drug release.
The goal of this work was to utilize the chondroitin sulfate (CS) based hydrogels for a drug delivery matrix. CS is a good structure/disease-modifying anti-osteroarthritis drug (S/DMOAD). However, the readily water-soluble nature limits its application as a solid-state drug-delivery vehicle. In this study, two methods were used to prepare CS hydrogels: directly crosslinking CS with poly(ethylene glycol) diglycidyl ether (EX-810) abbreviated as CS-EX or forming an interpenetrating polymer network named CS-EX-IPN. The CS-EX-IPN hydrogel was carried out by sequentially crosslinking reaction between CS and EX-810 in one phase and acrylic acid and di(ethylene glycol) diacrylate (DEGDA) as a counter phase. The swelling percent, cross-section morphology, and effective crosslinking density of hydrogels were characterized. The values of compression modulus and effective crosslinking density of CS-EX-IPN were approximately 3.6-fold higher than CS-EX. We also characterized the release of a model drug, diclofenac sodium (DS) and a model protein, bovine serum albumin (BSA), from CS-EX and CS-EX-IPN. The similar release profiles of DS were observed in the both hydrogels but slower release rate of BSA occurred in CS-EX-IPN. The release profiles of the two model drugs fit in a diffusion-controlled mechanism. The D(eff) values are in the order of 10(-5) for DS and 10(-7) for BSA.
Wang
Shiu-Chih
SC
College of Life Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan, ROC.
Chen
Bing-Hung
BH
Wang
Li-Fang
LF
Chen
Jenn-Shing
JS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002417:Cattle; D002809:Chondroitin Sulfates / Q000737:chemistry; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage; D016503:Drug Delivery Systems; D004853:Epoxy Resins / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000008:administration & dosage
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004853:Epoxy Resins; D020100:Hydrogels; D004008:Diclofenac; D012710:Serum Albumin, Bovine; C035364:Quetol 651; D002809:Chondroitin Sulfates