Circulating adiponectin levels in Kawasaki disease.
OBJECTIVE
To investigate the kinetics of adipocytokine in Kawasaki disease (KD).


METHODS
The plasma levels of adiponectin, IL-6 and TNF-alpha were measured in 20 patients with KD, 15 patients with acute febrile diseases (disease control, DC) and 15 healthy children (HC).


RESULTS
Plasma adiponectin levels in patients with acute KD were significantly lower (p < 0.01) than those with convalescent KD, DC and HC. The decreased levels of adiponectin negatively correlated with the increased levels of CRP and IL-6 in acute KD.


CONCLUSIONS
Hypoadiponectinaemia was shown during the acute phase of KD vasculitis. The downregulation of adiponectin secreted from adipose tissue may be closely linked to upregulation of systemic pro-inflammatory markers in acute KD.
Takeshita
Seiichiro
S
Junior College, University of Shizuoka, Shizuoka, Japan. takeshit@mx.ibaraki.ac.jp
Takabayashi
Humiyo
H
Yoshida
Naoki
N
D052242:Adiponectin / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002675:Child, Preschool; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015854:Up-Regulation / Q000502:physiology
D052242:Adiponectin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein