[Pharmacokinetic of antifungal drugs in order to optimize their administration].
Antifungal drugs for treating systemic mycoses are flucytosine, amphotéricin B, azoles and caspofungin. Their pharmacokinetics and pharmacodynamics are reviewed in order to determine the optimal modalities of their administration and the best dosing regimen for several populations: neonates, infants, patients with renal or liver disease, patients with hemodialysis or hemofiltration.
Tod
Michel
M
Pharmacie-toxicologie, Hôpital Cochin, Paris, France. michel.tod@cch.ap-hop-paris.fr
D000367:Age Factors; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D009181:Mycoses / Q000188:drug therapy; D006435:Renal Dialysis
D000935:Antifungal Agents