GATA factors in vertebrate heart development and disease.
Vertebrate heart formation is dependent upon complex hierarchical gene regulatory networks, which effect both the specification and differentiation of cardiomyocytes and subsequently cardiac morphogenesis. GATA-4, -5 and -6 comprise an evolutionarily conserved subfamily of transcription factors, which are expressed within the precardiac mesoderm from early stages in its specification and continue to be expressed within the adult heart. We review here the functional roles of individual GATA transcription factors in cardiac development, normal homeostasis and disease. We also review the cellular mechanisms employed to regulate the expression and downstream targets of the different GATA factors.
Brewer
Alison
A
Cardiovascular Division, Department of Cardiology, King's College London School of Medicine, London, SE5 9PJ, UK.
Pizzey
John
J
D000818:Animals; D019521:Body Patterning; D002454:Cell Differentiation; D050980:GATA Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006321:Heart / Q000196:embryology*; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D014714:Vertebrates / Q000196:embryology*
D050980:GATA Transcription Factors