[Effect to the serotonin transporter gene (5-HTT) on personality dimensions in individuals without psychopathology].
BACKGROUND
The aim of the present study was to assess the association between the serotonin transporter gene and the Temperament and Character Inventory (TCI) personality dimensions in subjects without psychopathology.


METHODS
Fifty seven individuals without psychiatric symptoms were assessed with the SCL-90, and the TCI. In all subjects a peripheral blood sample was taken to determine their genotypes, after informed consent. Three groups were formed according to the 5-HTT genotype: SS, SL and LL, and the TCI results were compared.


RESULTS
There was no association among the 5-HTT genotypes and any of the TCI subscales. There were also no statistical differences among any of the three groups divided by genotype only according to the TCI scores, as well as when compared with historical controls.


CONCLUSIONS
These results are consistent with other studies that have not found associations among the different measurements of personality and 5-HTT genotypes. Likewise, our data suggest that our sample can be useful as a source of controls for later studies. This is the first study assessing TCI dimensions and the 5-HTT gene in the Mexican population.
Lanzagorta
N
N
Unidad PET-Ciclotrón. Facultad de Medicina. Universidad Nacional Autónoma de México. México, D.F.
Alexanderson-Rosas
E
E
Ricalde
A
A
Gómez Caudillo
L
L
Sosa
A
A
Camarena
B
B
Aguilar
A
A
Fresán
A
A
Apiquián
R
R
Nicolini
H
H
D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000097:blood / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins