[A new sesqui-norlignan from Herpetospermum pedunculosum].
OBJECTIVE
To study the chemical components from the bioactive extract of Herpetospermum pedunculosum, a Tibetan medicinal herb for liver diseases.


METHODS
The isolation and purification of this extract were conducted by means of silica gels column chromatography and preparative HPLC. The structures of the compounds were elucidated based on their physical and chemical features, and spectral data.


RESULTS
Two lignans were isolated from this extract. They were elucidated as herpetone (I), dehydrodiconiferyl alcohol (II).


CONCLUSIONS
Compound I is a new compound with the rare structure of sesqui-norlignan. Compound II is isolated from the genus of Herpetospermum for the first time.
Zhang
Mei
M
Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. zhangmei63@yahoo.com.cn
Dong
Xiao-ping
XP
Deng
Yun
Y
Wang
Hui
H
Li
Xiao-nian
XN
Song
Qin
Q
D002850:Chromatography, Gel / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D019662:Cucurbitaceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D058428:Silica Gel; D012822:Silicon Dioxide
D017705:Lignans; D010636:Phenols; C526382:herpetone; C080686:dehydrodiconiferyl alcohol; D058428:Silica Gel; D012822:Silicon Dioxide