Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.
Alpha-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically active compounds.
Opatz
Till
T
Institut für Organische Chemie, Universität Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany. opatz@uni-mainz.de
Ferenc
Dorota
D
D007210:Indoleacetic Acids / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D009570:Nitriles / Q000737:chemistry*
D007210:Indoleacetic Acids; D007211:Indoles; D009570:Nitriles; C081306:N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide