title: Serum adiponectin and coronary heart disease risk in older Black and White Americans.
abstract: BACKGROUND
  Adiponectin may influence the risk of coronary heart disease (CHD) independently of traditional cardiovascular risk factors.
  
  
  OBJECTIVE
  Because body composition and adiponectin levels vary by race, we examined the relationship of adiponectin with prevalent and incident CHD in a cohort of older Black and White adults.
  
  
  METHODS
  We conducted a cross-sectional and prospective cohort study at two U.S. clinical centers.
  
  
  METHODS
  Participants included 3075 well-functioning adults between ages 70 and 79 yr enrolled in the Health, Aging, and Body Composition study.
  
  
  METHODS
  Prevalent CHD was defined as history of myocardial infarction, coronary artery bypass graft, percutaneous coronary transluminal angioplasty, angina, or major electrocardiogram abnormalities. After excluding those with prevalent CHD, incident CHD was defined as hospitalized myocardial infarction or CHD death.
  
  
  RESULTS
  At baseline, 602 participants (19.6%) had CHD. During 6 yr of follow-up, 262 (10.6%) incident CHD events occurred. Whites had higher median adiponectin than Blacks (12 vs. 8 microg/ml, P < 0.001). Race modified the effect of adiponectin (P for interaction was 0.002 for prevalent CHD, and P = 0.02 for incident CHD). Among Whites, an inverse association of adiponectin with CHD was explained by high-density lipoprotein and glucose. Among Blacks, a doubling of adiponectin was associated with a 40% higher risk of both prevalent CHD (odds ratio, 1.41; 95% confidence interval, 1.11-1.78) and incident CHD (hazards ratio, 1.37; 95% confidence interval, 1.01-1.87) after adjusting for explanatory variables.
  
  
  CONCLUSIONS
  High circulating concentrations of adiponectin were associated with higher risk of CHD in older Blacks, even accounting for traditional CHD risk factors.
authors.affiliation: Univerisity of California, San Francisco, California 94115, USA. Alka.Kanaya@ucsf.edu
authors.forename: Alka M
authors.initials: AM
authors.lastname: Kanaya
authors.forename: Christina
authors.initials: C
authors.lastname: Wassel Fyr
authors.forename: Eric
authors.initials: E
authors.lastname: Vittinghoff
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Havel
authors.forename: Matteo
authors.initials: M
authors.lastname: Cesari
authors.forename: Barbara
authors.initials: B
authors.lastname: Nicklas
authors.forename: Tamara
authors.initials: T
authors.lastname: Harris
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.forename: Suzanne
authors.initials: S
authors.lastname: Satterfield
authors.forename: Steve R
authors.initials: SR
authors.lastname: Cummings
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data
chemical_list: D052242:Adiponectin