Purine analogues: rationale for development, mechanisms of action, and pharmacokinetics in hairy cell leukemia.
Cladribine is effective therapy for HCL, and there are several ways to achieve the adequate concentrations of the active metabolites in relevant cells, without the need for long-term continuous infusions. This simplifies therapy, although careful control of patients is required during and after treatment in most instances because of the significant activity of the drug on leukemia cells of various types and also on lymphoid cells and normal stem cells.
Juliusson
Gunnar
G
Stem Cell Center, BMC B10, Lund University, SE-221 84 Lund, Sweden. Gunnar.Juliusson@med.lu.se
Liliemark
Jan
J
D000241:Adenosine / Q000031:analogs & derivatives* / Q000266:history / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000243:Adenosine Deaminase / Q000378:metabolism; D058892:Adenosine Deaminase Inhibitors; D000964:Antimetabolites, Antineoplastic / Q000266:history / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D003842:Deoxycytidine Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy* / Q000201:enzymology / Q000266:history; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
D058892:Adenosine Deaminase Inhibitors; D000964:Antimetabolites, Antineoplastic; D009363:Neoplasm Proteins; D003842:Deoxycytidine Kinase; D000243:Adenosine Deaminase; D000241:Adenosine