title: Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.
abstract: Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production.
authors.affiliation: Fachbereich Chemie/Biochemie der Philipps-Universität Marburg, Marburg, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Miethke
authors.forename: Helga
authors.initials: H
authors.lastname: Westers
authors.forename: Evert-Jan
authors.initials: EJ
authors.lastname: Blom
authors.forename: Oscar P
authors.initials: OP
authors.lastname: Kuipers
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Marahiel
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis*; D001412:Bacillus subtilis / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003470:Culture Media; D004952:Esters; D015964:Gene Expression Regulation, Bacterial; D007501:Iron / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D009842:Oligopeptides / Q000096:biosynthesis*; D020543:Proteome; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D003470:Culture Media; D004952:Esters; D009842:Oligopeptides; D020543:Proteome; D012097:Repressor Proteins; C430721:bacillibactin; C068477:ferric uptake regulating proteins, bacterial; D007501:Iron