Posttranslational modifications of NEMO and its partners in NF-kappaB signaling.
NEMO, the regulatory subunit of the IkappaB kinase (IKK) complex that controls the activation of the transcription factor NF-kappaB, is required for IKK function in most situations, but its exact mode of action has remained elusive until recently. A series of publications now provides information about how posttranscriptional modifications of NEMO, such as ubiquitination, sumoylation or phosphorylation, regulate its function in the IKK complex. These modifications might also regulate a cytosolic pool of free NEMO that controls the activation of NF-kappaB induced by genotoxic stress. Together with a better identification of the modifications controlling partners of NEMO, a clearer picture of how IKK becomes activated upon cell stimulation is starting to emerge, providing new clues for how the NF-kappaB pathway could be modulated for therapeutic purposes.
Sebban
Hélène
H
INSERM U697, Hôpital Saint-Louis, Paris 75010, France.
Yamaoka
Shoji
S
Courtois
Gilles
G
D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D013312:Stress, Physiological
C491731:IKBKG protein, human; D016328:NF-kappa B; D051550:I-kappa B Kinase