[Glycosylated hemoglobin and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus].
Glycosylated hemoglobin (HbA1c) is a confirmed prognostic factor of cardiovascular complications in diabetic patients. The relative odds of cardiovascular disease (CD) increase by 20% for 1% increase of HbA1c above HbA1c 5%. The aim of the study was to assess relationship between diastolic dysfunction and HbA1c in patients with diabetes mellitus 2 (DM 2) without critical coronary stenosis in coronarography.


METHODS
The study comprised 57 subjects (35 men and 22 women) with DM 2, without coronary stenosis in coronarography, with normal and elevated HbA1c levels. The subjects were divided into two groups depending on HbA1c level: with HbA1c < or = 6.1% and HbA1c >6.1%. Parameters of left ventricular diastolic function were assessed in echocardiography according to criterions of European Society of Cardiology. Subjects with decreased systolic function (EF<50%) were excluded from the study.


RESULTS
Diastolic dysfunction of the left ventricle was observed in 43% of patients with HbA1c >6.1% comparing to 4.5% of patients in the group with HbA1 < or = 6.1%. In the group with HbA1c >6.1% in 38% of the patients abnormal relaxation in early filling phase and in 5% abnormal isovolumetric relaxation were observed. In the group with HbA1 < or = 6.1% in only 1 patient (4.5%) abnormal relaxation in early filling phase was observed.


CONCLUSIONS
Diastolic function of the left ventricle in patients with diabetes is dependent on HbA1c levels.
Markuszewski
Leszek
L
Uniwersytet Medyczny w Lodzi, Klinika Kardiologii Interwencyjnej, Kardiodiabetologii i Rehabilitacji Kardiologicznej, I Katedra Kardiologii i Kardiochirurgii kardiolog@skwam.lodz.pl
Grycewicz
Tomasz
T
Pietruszyński
Robert
R
Michałkiewicz
Dariusz
D
Roszczyk
Nikolina
N
D000368:Aged; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism*; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*
D015415:Biomarkers; D006442:Glycated Hemoglobin