title: NC-100717: a versatile RGD peptide scaffold for angiogenesis imaging.
abstract: Targeting the molecular pathways associated with angiogenesis offers great potential in detecting disease pathology using in vivo imaging technologies. Initiation of angiogenesis requires activation and migration of endothelial cells in order for neovascularization to proceed. Endothelial cells associate with the extracellular matrix through specific interactions with a variety of cell adhesion receptors known as integrins. Peptides containing the tripeptide sequence RGD are known to bind with high affinity to the alphavbeta3 and alphavbeta5 integrins associated with angiogenesis. We present herein the synthesis and in vitro binding affinity of the RGD-containing peptide NC-100717 and a range of molecular probes derived from this intermediate.
authors.affiliation: GE Healthcare, Medical Diagnostics, Discovery Research, Oslo, Norway.
authors.forename: Bård
authors.initials: B
authors.lastname: Indrevoll
authors.forename: Grete Mørk
authors.initials: GM
authors.lastname: Kindberg
authors.forename: Magne
authors.initials: M
authors.lastname: Solbakken
authors.forename: Emma
authors.initials: E
authors.lastname: Bjurgert
authors.forename: John Henrik
authors.initials: JH
authors.lastname: Johansen
authors.forename: Hege
authors.initials: H
authors.lastname: Karlsen
authors.forename: Marivi
authors.initials: M
authors.lastname: Mendizabal
authors.forename: Alan
authors.initials: A
authors.lastname: Cuthbertson
mesh_terms: D042501:Angiogenic Proteins / Q000737:chemistry / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005109:Extracellular Matrix / Q000187:drug effects / Q000502:physiology; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000187:drug effects / Q000502:physiology; D008958:Models, Molecular; D018919:Neovascularization, Physiologic; D009842:Oligopeptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000494:pharmacology*
chemical_list: D042501:Angiogenic Proteins; D039302:Integrin alphaVbeta3; C517141:NC 100717; D009842:Oligopeptides; D010456:Peptides, Cyclic; C047981:arginyl-glycyl-aspartic acid