Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.
BACKGROUND
Previous studies have shown improvement in left ventricular function after intracoronary injection of autologous cells derived from bone marrow (BMC) in the acute phase of myocardial infarction. We designed a randomized, controlled trial to further investigate the effects of this treatment.


METHODS
Patients with acute ST-elevation myocardial infarction of the anterior wall treated with percutaneous coronary intervention were randomly assigned to the group that underwent intracoronary injection of autologous mononuclear BMC or to the control group, in which neither aspiration nor sham injection was performed. Left ventricular function was assessed with the use of electrocardiogram-gated single-photon-emission computed tomography (SPECT) and echocardiography at baseline and magnetic resonance imaging (MRI) 2 to 3 weeks after the infarction. These procedures were repeated 6 months after the infarction. End points were changes in the left ventricular ejection fraction (LVEF), end-diastolic volume, and infarct size.


RESULTS
Of the 50 patients assigned to treatment with mononuclear BMC, 47 underwent intracoronary injection of the cells at a median of 6 days after myocardial infarction. There were 50 patients in the control group. The mean (+/-SD) change in LVEF, measured with the use of SPECT, between baseline and 6 months after infarction for all patients was 7.6+/-10.4 percentage points. The effect of BMC treatment on the change in LVEF was an increase of 0.6 percentage point (95% confidence interval [CI], -3.4 to 4.6; P=0.77) on SPECT, an increase of 0.6 percentage point (95% CI, -2.6 to 3.8; P=0.70) on echocardiography, and a decrease of 3.0 percentage points (95% CI, 0.1 to -6.1; P=0.054) on MRI. The two groups did not differ significantly in changes in left ventricular end-diastolic volume or infarct size and had similar rates of adverse events.


CONCLUSIONS
With the methods used, we found no effects of intracoronary injection of autologous mononuclear BMC on global left ventricular function.
Lunde
Ketil
K
Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway. ketil.lunde@rikshospitalet.no
Solheim
Svein
S
Aakhus
Svend
S
Arnesen
Harald
H
Abdelnoor
Michael
M
Egeland
Torstein
T
Endresen
Knut
K
Ilebekk
Arnfinn
A
Mangschau
Arild
A
Fjeld
Jan G
JG
Smith
Hans Jørgen
HJ
Taraldsrud
Eli
E
Grøgaard
Haakon Kiil
HK
Bjørnerheim
Reidar
R
Brekke
Magne
M
Müller
Carl
C
Hopp
Einar
E
Ragnarsson
Asgrimur
A
Brinchmann
Jan E
JE
Forfang
Kolbjørn
K
D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods; D003331:Coronary Vessels; D003935:Diagnostic Techniques, Cardiovascular; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D013318:Stroke Volume; D014182:Transplantation, Autologous; D017211:Treatment Failure; D016277:Ventricular Function, Left