title: Survey of the year 2005: literature on applications of isothermal titration calorimetry.
abstract: Isothermal titration calorimetry (ITC) can provide a full thermodynamic characterization of an interaction. Its usage does not suffer from constraints of molecular size, shape or chemical constitution. Neither is there any need for chemical modification or attachment to solid support. This ease of use has made it an invaluable instrumental resource and led to its appearance in many laboratories. Despite this, the value of the thermodynamic parameterization has, only quite recently, become widely appreciated. Although our understanding of the correlation between thermodynamic data and structural details continues to be somewhat naïve, a large number of publications have begun to improve the situation. In this overview of the literature for 2005, we have attempted to highlight works of interest and novelty. Furthermore, we draw attention to those works which we feel have provided a route to better analysis and increased our ability to understand the meaning of thermodynamic change on binding.
authors.affiliation: Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Adessamad
authors.initials: A
authors.lastname: Ababou
authors.forename: John E
authors.initials: JE
authors.lastname: Ladbury
mesh_terms: D000818:Animals; D002118:Calcium; D002151:Calorimetry / Q000295:instrumentation* / Q000379:methods*; D003625:Data Collection; D051605:Kv Channel-Interacting Proteins / Q000032:analysis; D004364:Pharmaceutical Preparations; D013816:Thermodynamics; D017186:Titrimetry
chemical_list: D051605:Kv Channel-Interacting Proteins; D004364:Pharmaceutical Preparations; D002118:Calcium