Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31-34.
We performed a whole genome microsatellite marker scan in six multiplex families with bipolar (BP) mood disorder ascertained in Antioquia, a historically isolated population from North West Colombia. These families were characterized clinically using the approach employed in independent ongoing studies of BP in the closely related population of the Central Valley of Costa Rica. The most consistent linkage results from parametric and non-parametric analyses of the Colombian scan involved markers on 5q31-33, a region implicated by the previous studies of BP in Costa Rica. Because of these concordant results, a follow-up study with additional markers was undertaken in an expanded set of Colombian and Costa Rican families; this provided a genome-wide significant evidence of linkage of BPI to a candidate region of approximately 10 cM in 5q31-33 (maximum non-parametric linkage score=4.395, P<0.00004). Interestingly, this region has been implicated in several previous genetic studies of schizophrenia and psychosis, including disease association with variants of the enthoprotin and gamma-aminobutyric acid receptor genes.
Herzberg
Ibi
I
Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.
Jasinska
Anna
A
García
Jenny
J
Jawaheer
Damini
D
Service
Susan
S
Kremeyer
Barbara
B
Duque
Constanza
C
Parra
María V
MV
Vega
Jorge
J
Ortiz
Daniel
D
Carvajal
Luis
L
Polanco
Guadalupe
G
Restrepo
Gabriel J
GJ
López
Carlos
C
Palacio
Carlos
C
Levinson
Matthew
M
Aldana
Ileana
I
Mathews
Carol
C
Davanzo
Pablo
P
Molina
Julio
J
Fournier
Eduardo
E
Bejarano
Julio
J
Ramírez
Magui
M
Ortiz
Carmen Araya
CA
Araya
Xinia
X
Sabatti
Chiara
C
Reus
Victor
V
Macaya
Gabriel
G
Bedoya
Gabriel
G
Ospina
Jorge
J
Freimer
Nelson
N
Ruiz-Linares
Andrés
A
D001714:Bipolar Disorder / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D003105:Colombia; D003364:Costa Rica; D005260:Female; D018703:Founder Effect; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D018709:Statistics, Nonparametric