Interconversion kinetic studies of betamethasone acetate polymorphs in water.
This study assessed the effect of polymers on the transformation of polymorphs of betamethasone acetate (BA) when suspended in water. The results showed that the polymers, in particular HPMC E5, retarded the transition of the forms Ialpha and Ibeta. However, the form Ialpha, as the metastable form, with the aid of HPMC E5, was preferred for BA suspension preparation through kinetic studies, while the form Ibeta was not suitable due to its instability in water.
Ke
Xue
X
Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Ping
QiNeng
Q
Liao
ZhengGen
Z
D001623:Betamethasone / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D018360:Crystallography, X-Ray; D007700:Kinetics; D014867:Water / Q000737:chemistry*
D014867:Water; D001623:Betamethasone