title: Eptifibatide-induced thrombocytopenia and thrombosis.
abstract: Glycoprotein (GP) IIb/IIIa inhibitors have been shown to reduce morbidity and mortality in patients with acute coronary syndromes undergoing percutaneous coronary interventions (PCI). With their widespread use, there is a growing body of literature describing adverse outcomes, including severe thrombocytopenia. Here we report a case of a 75-year-old man who presented with an ST-elevation myocardial infarction, underwent primary PCI and stenting, and subsequently developed profound thrombocytopenia and thrombosis after eptifibatide administration. This report adds to the literature regarding eptifibatide-induced thrombocytopenia and also raises the possibility of a new syndrome of eptifibatide-induced thrombosis. A case is made to examine available databases for thrombosis after administration of eptifibatide and other GPIIb/IIIa inhibitors.
authors.affiliation: Division of Internal Medicine, The Cleveland Clinic, USA.
authors.forename: Slava
authors.initials: S
authors.lastname: Epelman
authors.forename: Deepu
authors.initials: D
authors.lastname: Nair
authors.forename: Ross
authors.initials: R
authors.lastname: Downey
authors.forename: Mike
authors.initials: M
authors.lastname: Militello
authors.forename: Arman T
authors.initials: AT
authors.lastname: Askari
mesh_terms: D000368:Aged; D000077542:Eptifibatide; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy; D010455:Peptides / Q000009:adverse effects* / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D013921:Thrombocytopenia / Q000139:chemically induced*; D020246:Venous Thrombosis / Q000139:chemically induced*
chemical_list: D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D000077542:Eptifibatide