title: The discovery of an enantioselective receptor for (-)-adenosine from a racemic dynamic combinatorial library.
abstract: The use of laser polarimetry detection coupled with HPLC is demonstrated to enable the discovery of enantioselective receptors from racemic dynamic combinatorial libraries. Templating with an enantiopure analyte, such as (-)-adenosine, leads to amplification of one enantiomer of the cyclic dimer. A result confirmed with a pseudo-racemic library wherein one of the enantiomers was d-labeled for mass spec analysis. The resulting dimer is thus an enantioselective receptor for (-)-adenosine.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Voshell
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné
mesh_terms: D000241:Adenosine / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004151:Dipeptides / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D018047:Receptors, Purinergic P1 / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D004151:Dipeptides; D006835:Hydrazones; D018047:Receptors, Purinergic P1; D011392:Proline; D000241:Adenosine