[Diagnosis and therapy of Rhodococcus equi infection in the horse].
Infection with Rhodococcus equi is an important cause of pneumonia in foals, but other organ systems may also be affected. The intracellular presence of R. equi and the formation of granulomatous and suppurative inflammatory tissue mean that prolonged treatment is needed. The pharmacological properties of the combination of erythromycin and rifampicin have improved the survival of foals infected with R. equi; however, erythromycin can cause adverse reactions in foals and mares, which has prompted the search for alternative therapies. The combination of azithromycin or clarithromycin with rifampicin seems to be a promising alternative. However these combinations are expensive and adverse effects remain to be determined, especially in the dams of treated foals. Thus correct diagnosis and appropriate use of drugs are essential for the treatment of R. equi infection in foals.
Boswinkel
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Departement Gezondheidszorg Paard, Discipline Inwendige Ziekten, Faculteit der Diergeneeskunde, Universiteit Utrecht, Yalelaan 114, 3584 CM Utrecht. m.boswinkel@vet.uu.nl
Sloet van Oldruitenborgh-Oosterbaan
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MM
D000193:Actinomycetales Infections / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D017963:Azithromycin / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D017291:Clarithromycin / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D006734:Horse Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D006736:Horses; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D016929:Rhodococcus equi; D012293:Rifampin / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin; D012293:Rifampin