title: The role of nitric oxide in mediating tumour blood flow.
abstract: Nitric oxide (NO) is a ubiquitous molecule with a myriad of physiological and pathophysiological roles. It has numerous direct and indirect effects on tumour vasculature as both a regulatory and effector molecule. NO affects tumour blood flow through its effects on tumour angiogenesis, vascular tone and vascular permeability, partly via its interaction with vascular endothelial growth factor. In this review, the authors examine the basic tenants of NO biology, the association of NO with tumour progression, and the role NO plays in mediating alterations in vascular functions in tumours.
authors.affiliation: University of Texas, MD Anderson Cancer Center, Department of Surgical Oncology, Houston, TX 77230, USA.
authors.forename: George
authors.initials: G
authors.lastname: Van Buren
authors.forename: E Ramsay
authors.initials: ER
authors.lastname: Camp
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Yang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gray
authors.forename: Fan
authors.initials: F
authors.lastname: Fan
authors.forename: Ray
authors.initials: R
authors.lastname: Somcio
authors.forename: Lee M
authors.initials: LM
authors.lastname: Ellis
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism*; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase