title: Factors affecting long-term clinical outcomes of endoscopic mucosal resection of early gastric cancer.
abstract: OBJECTIVE
  Endoscopic mucosal resection (EMR) has been widely accepted as a treatment option for early gastric cancer (EGC) in selected cases. The purposes of this study were to evaluate the long-term outcomes and the factors affecting the clinical outcomes, of EMR performed in EGC.
  
  
  METHODS
  Between April 1996 and March 2005, 147 patients have undergone EMR to treat EGC at Yonsei University Medical Center, Seoul, Korea. We assessed the clinical outcomes of the EMR for EGC in a long-term follow-up period. We also reviewed the medical records of the patients including demographic data, endoscopic characteristics of the lesion and histopathologic findings.
  
  
  RESULTS
  The histopathologic evaluations after the EMR treatment showed that overall complete resection rate was 84.6% (126/149) while complete resec tion rate of 93.5% was achieved in mucosal cancers (115/123). The success of complete resection was significantly affected by endoscopic gross type (depressed lesion), the degree of differentiation, and the depth of invasion, independently. There were only 5 cases of local recurrence during the follow-up periods, and the recurred or incompletely resected lesions were successfully treated by salvage operation or endoscopic retreatment. There was no disease-related or treatment-related mortality during the follow-up period.
  
  
  CONCLUSIONS
  EMR is a good and safe curative treatment option with feasible clinical outcomes in patients with EGC. It must be emphasized that a proper selection of candidates is mandatory to improve the clinical outcome of EMR in EGC.
authors.affiliation: Department of Internal Medicine, Institute of Gastroenterology, Brain Korea 21 Project for Medical Science Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jong Chan
authors.initials: JC
authors.lastname: Youn
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Youn
authors.forename: Tae Il
authors.initials: TI
authors.lastname: Kim
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Se Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Si Young
authors.initials: SY
authors.lastname: Song
authors.forename: Jae Bock
authors.initials: JB
authors.lastname: Chung
authors.forename: Youn Chan
authors.initials: YC
authors.lastname: Lee
authors.forename: J C
authors.initials: JC
authors.lastname: Youn
authors.forename: Y H
authors.initials: YH
authors.lastname: Youn
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D005753:Gastric Mucosa / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome