Possible mechanism of pesticide toxicity-related oxidative stress leading to airway narrowing.
The study was conducted to assess the magnitude of oxidative stress and lung function abnormalities in 34 male pesticide sprayers on exposure to pesticides in mango plantations. Biochemical studies on blood antioxidant enzymes revealed an unchanged glutathione level and increased level of malondialdehyde (P < 0.001), which indicates that pesticide sprayers may have suffered from oxidative stress. Decreased acetyl-cholinesterase levels (P < 0.001) in sprayers compared to the controls suggest inhibition of cholinesterase activity. The present study shows that pesticide toxicity might lead to oxidative stress and airway narrowing resulting in decreased peak expiratory flow rate.
Kesavachandran
C
C
Epidemiology Section, Industrial Toxicology Research Centre, Lucknow, India.
Singh
Vipul K
VK
Mathur
N
N
Rastogi
S K
SK
Siddiqui
M K J
MK
Reddy
M M K
MM
Bharti
R S
RS
Khan
Asif M
AM
D000293:Adolescent; D000328:Adult; D000402:Airway Obstruction / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D000975:Antioxidants / Q000378:metabolism; D002802:Cholinesterases / Q000097:blood; D003430:Cross-Sectional Studies; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress; D010573:Pesticide Residues / Q000097:blood; D010575:Pesticides / Q000506:poisoning*
D000975:Antioxidants; D010573:Pesticide Residues; D010575:Pesticides; D008315:Malondialdehyde; D002802:Cholinesterases; D005978:Glutathione