Synthesis of omega-(hetero)arylalkynylated alpha-amino acid by Sonogashira-type reactions in aqueous media.
Mild conditions are described that allow the palladium-catalyzed cross-coupling of C(alpha)-alkynylated glycine with a wide variety of electron-rich and electron-poor aryl and heteroaryl halides in aqueous media.
Brea
Roberto J
RJ
Departamento de Química Organica e Unidade Asociada ó C.S.I.C., Facultade de Química, Universidade de Santiago, 15782 Santiago de Compostela, Spain.
López-Deber
M Pilar
MP
Castedo
Luis
L
Granja
Juan R
JR
D000480:Alkynes / Q000737:chemistry; D024322:Amino Acids, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005998:Glycine / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D012996:Solutions; D014867:Water
D000480:Alkynes; D024322:Amino Acids, Aromatic; D006846:Hydrocarbons, Halogenated; D012996:Solutions; D014867:Water; D010165:Palladium; D005998:Glycine