[Effect of RGD-containing peptides on platelet aggregation].
The influence of new synthetic peptides ARGDS-NH2 and RGD-dFK (synthesized by the fermentative method) and VPNLRGDLQVLA (a fragment of the foot-and-mouth virus's surface peptide) on the ADP-induced human platelet aggregation in vitro was studied. All peptides were found to inhibit the human platelet aggregation, but the synthetic peptides (ARGDS-NH2 and RGD-dFK) showed the most pronounced effect. Significant decrease in the platelet aggregation was observed at their concentrations within 0.1-10 mM. ARGDS-NH2 and RGD-dFK inhibited the platelet aggregation stronger than the reference drug pentoxifylline at equivalent concentrations.
Vasil'eva
T M
TM
Makarov
V A
VA
Petrukhina
G N
GN
Voiushina
T L
TL
Iusupova
M P
MP
Novgorodova
S A
SA
Kotlova
E K
EK
D029544:Foot-and-Mouth Disease Virus; D006801:Humans; D066298:In Vitro Techniques; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D010431:Pentoxifylline / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D010979:Platelet Function Tests; D014758:Viral Core Proteins / Q000737:chemistry
D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; D014758:Viral Core Proteins; C047981:arginyl-glycyl-aspartic acid; D010431:Pentoxifylline