Cancer's molecular sweet tooth and the Warburg effect.
More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have renewed discussions about its exact role as cause, correlate, or facilitator of cancer. Molecular advances in this area may reveal tactics to exploit the cancer cell's "sweet tooth" for cancer therapy.
Kim
Jung-whan
JW
Division of Hematology, Department of Medicine, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Dang
Chi V
CV
D000332:Aerobiosis; D000818:Animals; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism
D051793:Hypoxia-Inducible Factor 1; D011768:Pyruvate Dehydrogenase Complex; D019344:Lactic Acid; D005947:Glucose