title: [A clinical study of prostat combined with an antibiotic for chronic nonbacterial prostatitis].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of Prostate in combination with an antibiotic for the treatment of chronic nonbacterial prostatitis.
  
  
  METHODS
  A double-blind, parallel contrasted, multi-central method was applied in the study. After the Stamey test and expressed prostate secretion (EPS) examination, 160 patients with prostatitis were recruited and randomized into a trial group (80 cases with 1 case missing) and a control group (80 cases). In the trial group, the patients used the levofloxacin and Prostate during the first 4 weeks and Prostate only during the following 4 weeks. In the control group, the patients used the levofloxacin and placebo during the first 4 weeks, and placebo only during the following 4 weeks. Before and 4 and 8 weeks after the treatment, the patients were visited and evaluated by the national institute health-chronic prostatitis symptom index (NIH-CPSI), EPS, and asked about the side.
  
  
  RESULTS
  After 4-week and 8-week treatment, the pain index dropped by 3.34 +/- 2.45 and 4.06 +/- 3.03 in the trial group, and effects. 2.28 +/- 2.42 and 3.30 +/- 3.29 in the control; the voiding index dropped by 2.22 +/- 1.79 and 2.77 +/- 2.04 in the trial group, and 1.24 +/- 1.67 and 1.83 +/- 2.25 in the control respectively. There was significant difference between pre-treatment and post-treatment in both the two groups (P < 0.01), while the difference was not significant between 4-week and 8-week post-treatment (P > 0.05). And there was significant difference between the two groups in the pain index and voiding index (P < 0.01), but not in the white blood cell count and lipid in the EPS (P > 0.05). No serious side effects were recorded, and the tolerance to Prostate and placebo showed no significant difference.
  
  
  CONCLUSIONS
  Prostate in combination with an antibiotic can effectively relieve the pain and voiding symptoms and improve the life quality of the patients with nonbacterial prostatitis and well deserves to be recommended in clinical practice.
authors.affiliation: Department of Urology, Tongii Hospital Affiliated to Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430030, China.
authors.forename: Zhang-qun
authors.initials: ZQ
authors.lastname: Ye
authors.forename: Ru-zhu
authors.initials: RZ
authors.lastname: Lan
authors.forename: Shao-gang
authors.initials: SG
authors.lastname: Wang
authors.forename: Song-liang
authors.initials: SL
authors.lastname: Cai
authors.forename: Ge-ming
authors.initials: GM
authors.lastname: Chen
authors.forename: Ning-chen
authors.initials: NC
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Song
authors.forename: Yan-qun
authors.initials: YQ
authors.lastname: Na
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011058:Pollen; D011472:Prostatitis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; C508434:Prostat Poltit