title: Hormonal activity of AIMP1/p43 for glucose homeostasis.
abstract: AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic alpha cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.
authors.affiliation: National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors.forename: Sang Gyu
authors.initials: SG
authors.lastname: Park
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Kang
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Chang Seok
authors.initials: CS
authors.lastname: Lee
authors.forename: Young Gyu
authors.initials: YG
authors.lastname: Ko
authors.forename: Woo Je
authors.initials: WJ
authors.lastname: Lee
authors.forename: Ki-Up
authors.initials: KU
authors.lastname: Lee
authors.forename: Young Il
authors.initials: YI
authors.lastname: Yeom
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Kim
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D016207:Cytokines / Q000172:deficiency / Q000378:metabolism*; D020869:Gene Expression Profiling; D005934:Glucagon / Q000097:blood; D050416:Glucagon-Secreting Cells / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D005947:Glucose / Q000378:metabolism*; D050261:Glycogenolysis / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D007003:Hypoglycemia; D008066:Lipolysis / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D021381:Protein Transport
chemical_list: C514492:Aimp1 protein, mouse; D016207:Cytokines; D005934:Glucagon; D005947:Glucose