title: Diversity-oriented approach to biologically relevant molecular frameworks starting with beta-naphthol and using the Claisen rearrangement and olefin metathesis as key steps.
abstract: A diversity-oriented approach for the synthesis of various structurally different molecular frameworks from readily accessible and common precursors is described. A Claisen rearrangement followed by ring-closing metathesis or ethylene-promoted ring-closing enyne metathesis has been utilized as the key synthetic transformation to generate naphthoxepine derivatives. The ring-closing metathesis approach has also been used to generate spirocyclic compounds and the pleiadene framework.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Bombay, Powai, Mumbai-400 076, India. srk@chem.iitb.ac.in
authors.forename: Sambasivarao
authors.initials: S
authors.lastname: Kotha
authors.forename: Kalyaneswar
authors.initials: K
authors.lastname: Mandal
authors.forename: Arti
authors.initials: A
authors.lastname: Tiwari
authors.forename: Shaikh M
authors.initials: SM
authors.lastname: Mobin
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D009284:Naphthols / Q000737:chemistry*; D010082:Oxepins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D009284:Naphthols; D010082:Oxepins; C028405:2-naphthol