Radical scavenging and NO-releasing properties of selected beta-adrenoreceptor antagonists.
It is claimed that novel beta-adrenolytic drugs possess superior antioxidant properties as compared to classical selective or non-selective beta-adrenoceptor antagonists. Here we tested this notion by analyzing radical scavenging properties of selected beta-adrenolytic drugs and their ability to release nitric oxide in biological preparations. Selective beta1-adrenolytics such as nebivolol, atenolol, metoprolol and non-selective beta-adrenolytics with alpha1-receptor blocking properties such as carvedilol and labetalol were chosen for analysis. NO-releasing properties of nebivolol and carvedilol distinguished third generation beta-adrenolytics from their older counterparts while the reactivity towards hydroxyl and peroxyl radicals discerns only carvedilol but not nebivolol. Thus, superior clinical efficacy of third generation beta-adrenolytics may be related to their ability to release NO rather then to their direct antioxidant properties.
Szajerski
Piotr
P
Institute of Applied Radiation Chemistry, Technical University, Zeromskiego 116, 90-924 Lodz, Poland.
Zielonka
Jacek
J
Sikora
Adam
A
Adamus
Jan
J
Marcinek
Andrzej
A
Gebicki
Jerzy
J
Kozlovski
Valery I
VI
Drelicharz
Lukasz
L
Chłopicki
Stefan
S
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D002227:Carbazoles / Q000494:pharmacology; D000077261:Carvedilol; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D004852:Epoxy Compounds / Q000737:chemistry / Q000378:metabolism; D004983:Ethanolamines / Q000494:pharmacology; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008744:Methylamines / Q000737:chemistry / Q000378:metabolism; D000068577:Nebivolol; D009569:Nitric Oxide / Q000378:metabolism*; D011412:Propanolamines / Q000494:pharmacology; D011675:Pulse Radiolysis; D014664:Vasodilation / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D002227:Carbazoles; D004852:Epoxy Compounds; D004983:Ethanolamines; D016166:Free Radical Scavengers; D008744:Methylamines; D011412:Propanolamines; D000068577:Nebivolol; D000077261:Carvedilol; D009569:Nitric Oxide; C027451:methylamine; C009068:propylene oxide