[Comparative analysis of antiarrhythmic and proarrhythmogenic effects of drugs for neuroleptanalgesia, ataralgesia, and antidepranalgesia in experimental acute myocardial infarction].
Proarrhythmogenic and antiarrhythmic effects of drugs for neuroleptanalgesia (NLA), ataralgesic (ATA) and antidepranalgesia (ADA) in chronic experiments on sleepless rabbits with acute myocardial infarction, with and without tachyarrhythmias, were studied using ECG, intraventricular electromanometry and tetropolar rheography. NLA (phentanylum, 1 microg/kg + droperidol, 5 microg/kg), ADA (pyrazidole, 1 mg/kg + tramal, 1 mg/kg) and ATA (diazepam, 1 mg/kg + promedol 0.5 mg/kg) produce antiarrhythmic effect with maximum manifestation of NLA on the 3rd day, and of ATA and ADA on 3-5th day. This medication increased blood supply and contractility of ischemic myocardium. Proarrhythmogenic effects of this medication were not observed.
Iakushev
A M
AM
Iakushev
M P
MP
Sapozhkov
A V
AV
D000698:Analgesia / Q000009:adverse effects / Q000379:methods*; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000009:adverse effects / Q000627:therapeutic use; D003975:Diazepam / Q000009:adverse effects / Q000627:therapeutic use; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000627:therapeutic use*; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000503:physiopathology*; D009458:Neuroleptanalgesia / Q000009:adverse effects; D011396:Promedol / Q000009:adverse effects / Q000627:therapeutic use; D011817:Rabbits; D013610:Tachycardia / Q000188:drug therapy; D014147:Tramadol / Q000009:adverse effects / Q000627:therapeutic use
D000701:Analgesics, Opioid; D000889:Anti-Arrhythmia Agents; D000928:Antidepressive Agents; D002227:Carbazoles; D006993:Hypnotics and Sedatives; D014147:Tramadol; D011396:Promedol; D003975:Diazepam; C009830:pirlindole