Cardiac troponin I release in non-ischemic reversible myocardial injury from parvovirus B19 myocarditis.
Cardiac troponin I is released from myocytes in both reversible and irreversible myocardial injury. The changes in myocyte membrane permeability resulting from the injury could be enough for the release of cardiac troponins from the free cytosolic pool of myocytes without structural damage. We report a case of parvovirus B19 myocarditis in a 26-year-old male who developed regional wall motion abnormalities and severe left ventricular systolic dysfunction with elevated serum levels of cardiac troponin I (peak=11.7 ng/ml). Diagnosis of parvovirus myocarditis was confirmed by presence of high titers of parvovirus B19 IgG and identification of parvovirus B19 DNA by polymerase chain reaction. Within a few days of supportive treatment, the regional wall motion abnormalities resolved, the cardiac function recovered, and the elevation in serum cardiac troponin I subsided. This case further denotes the possibility of release of cardiac troponin I in non-ischemic, reversible myocardial injury.
Baig
Muhammad A
MA
Ali
Shaukat
S
Khan
Mutahir U
MU
Rasheed
Javeria
J
Qadir
Abdul
A
Vasavada
Balendu C
BC
Khan
Ijaz A
IA
D000328:Adult; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000378:metabolism* / Q000821:virology*; D010322:Parvoviridae Infections / Q000150:complications / Q000378:metabolism*; D016732:Parvovirus B19, Human; D019210:Troponin I / Q000378:metabolism*
D019210:Troponin I