A case of haemangiopericytoma-associated hypoglycaemia: Beneficial effect of treatment with radiotherapy.
A 72-year-old lady presented with recurrent hypoglycaemia and a large pelvic mass. Hypoglycaemia was accompanied by undetectable serum insulin and c-peptide and high insulin-like growth factor II (IGFII) to IGFI ratio. She had undergone successful resection of a large bladder haemangiopericytoma 7 years earlier. A core biopsy was performed, and histology confirmed the recurrence of the haemangiopericytoma. Local palliative radiotherapy resulted in the reduction of IGFII level and IGFII to IGFI ratio and increased insulin, c-peptide and growth hormone (GH) level with long-term amelioration of hypoglycaemic episodes. Clinically and biochemically, radiotherapy was more effective than GH therapy.
Soran
H
H
Department of Medicine, Wirral Hospital NHS-Trust, Wirral, Cheshire, UK. hsoran@aol.com
Younis
N
N
Joseph
F
F
Hayat
Z
Z
Zakhour
H
H
Scott
A
A
D000368:Aged; D005260:Female; D006393:Hemangiopericytoma / Q000150:complications / Q000532:radiotherapy*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D012008:Recurrence; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000532:radiotherapy*
D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II