Synthesis and circular dichroism spectroscopic investigations of oligomeric beta-peptoids with alpha-chiral side chains.
Biomimetic oligomers are of large interest both as targets for combinatorial and parallel synthetic efforts and as foldamers. For example, shorter peptoid derivatives of beta-peptides, i.e., oligo-N-substituted beta-Ala, have been described as potential lead structures. Herein, we describe a solid-phase synthetic route to beta-peptoids with alpha-chiral aromatic N-substituents up to 11 residues long. Furthermore, the folding propensities of these oligomers were investigated by circular dichroism (CD) spectroscopy.
Norgren
Anna S
AS
Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, SE-751 23 Uppsala, Sweden.
Zhang
Suode
S
Arvidsson
Per I
PI
D001704:Biopolymers; D002942:Circular Dichroism / Q000379:methods*; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001704:Biopolymers; D034444:Peptoids