title: Evaluation of corn furan fatty acid putative endocrine disruptors on reproductive performance in adult female chickens.
abstract: Based on evidence from rodent models, it was hypothesized that furan fatty acids found in corn would inhibit reproduction in the laying hen. An isomeric mixture of furan fatty acids [9, (12)-oxy-10,13-dihydroxystearic acid and 10, (13)-oxy-9,12-dihydroxystearic acid] was administered for a period of 3 wk via the diet (1 and 3 ppm) at levels greater than those in corn to 20-wk-old pullets. There were no overt indications of acute or chronic toxicity (no effects on mortality, feed intake, or average daily gain). Similarly, there was no dose-dependent effect on reproductive parameters [egg production, egg weight, shell thickness, ovarian weight, number or weight of large yolky preovulatory follicles, and number of small yellow follicles (4-8 mm in diameter)]. The present data do not suggest that furan fatty acids are a cause of concern to the poultry industry.
authors.affiliation: Interdepartmental Toxicology Program, Department of Animal Science, Iowa State University, Ames 50011, USA.
authors.forename: K W
authors.initials: KW
authors.lastname: Wilhelms
authors.forename: G A
authors.initials: GA
authors.lastname: Kraus
authors.forename: J D
authors.initials: JD
authors.lastname: Schroeder
authors.forename: J W
authors.initials: JW
authors.lastname: Kim
authors.forename: S A
authors.initials: SA
authors.lastname: Cutler
authors.forename: M A
authors.initials: MA
authors.lastname: Rasmussen
authors.forename: L L
authors.initials: LL
authors.lastname: Anderson
authors.forename: C G
authors.initials: CG
authors.lastname: Scanes
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002645:Chickens / Q000502:physiology*; D004032:Diet / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005227:Fatty Acids / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity*; D005260:Female; D009929:Organ Size; D010053:Ovary / Q000033:anatomy & histology / Q000187:drug effects; D010058:Oviposition / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D013229:Stearic Acids / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity*; D003313:Zea mays / Q000737:chemistry*
chemical_list: C450724:12-oxy-10,13-dihydroxystearic acid; C450723:13-oxy-9,12-dihydroxystearic acid; D005227:Fatty Acids; D013229:Stearic Acids