Effects of semax against the background of dopaminergic receptor blockade with haloperidol.
We studied the neurotropic effects of ACTH(4-10) analog semax against the background of dopaminergic receptors blockade with haloperidol. Intranasal administration of semax (0.05, 0.2, and 0.6 mg/kg) produced virtually no effect on disturbances of orientation and exploratory reactions and motor activity caused by intraperitoneal injection of 0.2 mg/kg haloperidol. By contrast, preliminary administration of 0.05 mg/kg semax prevented haloperidol-induced disturbances in active avoidance conditioning.
Sebentsova
E A
EA
Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University.
Levitskaya
N G
NG
Andreeva
L A
LA
Alfeeva
L Yu
LY
Kamenskii
A A
AA
Myasoedov
N F
NF
D000281:Administration, Intranasal; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D018492:Dopamine Antagonists / Q000008:administration & dosage*; D004347:Drug Interactions; D005106:Exploratory Behavior / Q000187:drug effects; D006220:Haloperidol / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D009949:Orientation / Q000187:drug effects; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*
D018492:Dopamine Antagonists; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D011954:Receptors, Dopamine; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D006220:Haloperidol