[Effects of the zinc oxide and cod liver oil containing ointment Zincojecol in an animal model of wound healing].
The effects of Zincojecol an ointment containing zinc oxide and cod liver oil on wound healing were compared with ointments that either contained no active ingredients or zinc oxide or cod liver oil alone. All formulations enhanced the epidermal proliferation after mechanical irritation of the tail skin. The combination of zinc oxide and cod liver oil was found to be superior to the vehicle control and formulations containing only one active ingredient. This combination was also found to be most efficient in accelerating wound healing being retarded by repeated dexamethasone treatment.
Kietzmann
M
M
Institut für Pharmakologie, Toxikologie und Pharmazie Stiftung Tierärztliche Hochschule Hannover.
Braun
M
M
D000818:Animals; D003060:Cod Liver Oil / Q000494:pharmacology* / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004357:Drug Synergism; D051379:Mice; D011897:Random Allocation; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D015034:Zinc Oxide / Q000494:pharmacology* / Q000627:therapeutic use
D003879:Dermatologic Agents; D003060:Cod Liver Oil; D015034:Zinc Oxide