title: Long-term follow-up of patients treated with a combination of continuous ambulatory peritoneal dialysis and hemodialysis.
abstract: Continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) both have advantages in the treatment of patients with renal failure. In CAPD, solute removal is sometimes insufficient in patients who have a relatively large muscle mass that produces high levels of creatinine. To compensate for this deficiency, frequent exchanges and large dialysate volumes are required. We previously reported that once-weekly HD helps CAPD patients who experience insufficient solute removal. In the present study, we followed, for more than 3 years, 9 CAPD patients who underwent additional weekly HD. Add-on HD therapy significantly increased the subjects' weekly peritoneal creatinine clearance to 45 +/- 3 L (mean +/- standard deviation); these values rose to more than 60 L over the course of the study. Our findings suggest that the combined use of CAPD and HD improves solute clearance in CAPD patients who are insufficiently dialyzed.
authors.affiliation: Department of Nephrology, Saitama Medical School, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hoshi
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Nakamoto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kanno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takane
authors.forename: Naofumi
authors.initials: N
authors.lastname: Ikeda
authors.forename: Soichi
authors.initials: S
authors.lastname: Sugahara
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Okada
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D003404:Creatinine / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects / Q000379:methods*; D010538:Peritonitis / Q000209:etiology; D006435:Renal Dialysis / Q000379:methods*; D012709:Serum Albumin / Q000032:analysis
chemical_list: D006454:Hemoglobins; D012709:Serum Albumin; D003404:Creatinine