Increased levels of inflammatory markers in hypertensives with target organ damage.
BACKGROUND
Inflammatory markers have been reported to be elevated in hypertension.


OBJECTIVE
We compared levels of inflammatory markers between hypertensives (HT) with target organ damage (TOD) but without associated clinical conditions (ACC), n=55, HT with ACC, n=42, HT without TOD/ACC, n=22 and normotensive controls, n=41.


METHODS
Serum levels of CRP, fibrinogen, TNF-alpha and anti-HSP60 antibodies were measured. Hypertensive complications were assessed on the basis of clinical history and the following investigations: M-mode echocardiography (left ventricular hypertrophy), Doppler: mitral and pulmonary vein flow and isovolumetric relaxation time (diastolic dysfunction), vascular ultrasound (common carotid artery intima-media thickness--IMT), pulse wave velocity (carotid-femoral arterial stiffness) and creatinine concentration (renal function).


RESULTS
HT with TOD had higher concentrations of CRP than controls (1.71 vs 0.76 mg/l, p <0.0001); higher fibrinogen and TNF-a vs controls and also vs HT without TOD/ACC (2.80 vs 2.53 vs 2.49 g/l, p <0.0001) and (2.49 vs 2.00 vs 1.83 pg/ml, p=0.04), respectively. HT without TOD/ACC did not differ from the control group in inflammatory marker concentrations. HT with ACC did not differ from HT with TOD in inflammatory marker concentrations. There were no differences in anti-HSP60 antibody concentrations between all groups. In multiple regression analysis only IMT was influenced by inflammatory markers: fibrinogen (beta=0.2, p=0.02) and TNF-alpha, (beta=0.17, p=0.05).


CONCLUSIONS
We conclude that inflammatory markers are elevated in HT with TOD and are not elevated in uncomplicated HT without TOD.
Jastrzebski
Marek
M
I Klinika Kardiologii, ul. Kopernika 17, 31-501 Kraków, Poland. mcjastrz@cyf-kr.edu.pl
Czarnecka
Danuta
D
Rajzer
Marek
M
Kawecka-Jaszcz
Kalina
K
D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis; D002340:Carotid Artery Diseases / Q000209:etiology / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000378:metabolism*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000378:metabolism; D007249:Inflammation / Q000150:complications* / Q000378:metabolism*; D007674:Kidney Diseases / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D005340:Fibrinogen; D002097:C-Reactive Protein