title: Comparison of respiratory surrogates for gated lung radiotherapy without internal fiducials.
abstract: An investigation was carried out to compare the ability of two respiratory surrogates to mimic actual lung tumor motion during audio coaching. The investigation employed video clips acquired after patients had had fiducial markers implanted in lung tumors to be used for image-guided stereoscopic radiotherapy. The positions of the markers in the clips were measured within the video frames and used as the standard for tumor volume motion. An external marker was tracked optically during the fluoroscopic acquisitions. An image correlation technique was developed to compute a gating signal from the fluoroscopic images. The correlation gating trace was similar to the optical gating trace in the phase regions of the respiratory cycle used for gating. A cross correlation analysis and comparison of the external optical marker gating with internal fluoroscopic gating was performed. The fluoroscopic image correlation surrogate was found to be superior to the external optical surrogate in the AP-views in four out of six cases. In one of the remaining two cases, the two surrogates performed comparably, while in the last case, the external fiducial trace performed best. It was concluded that fluoroscopic gating based on correlation of native image features in the fluoroscopic images will be adequate for respiratory gating.
authors.affiliation: Department of Radiation Oncology, Rigshospitalet, Copenhagen, Denmark. stine.k@rh.dk
authors.forename: S
authors.initials: S
authors.lastname: Korreman
authors.forename: H
authors.initials: H
authors.lastname: Mostafavi
authors.forename: Q-T
authors.initials: QT
authors.lastname: Le
authors.forename: A
authors.initials: A
authors.lastname: Boyer
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000601:surgery*; D003952:Diagnostic Imaging; D005471:Fluoroscopy / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008175:Lung Neoplasms / Q000175:diagnosis / Q000601:surgery*; D008962:Models, Theoretical; D009038:Motion; D016634:Radiosurgery / Q000379:methods*; D012119:Respiration; D025321:Surgery, Computer-Assisted
chemical_list: D015415:Biomarkers