From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease.
Glutamate toxicity through NMDA receptor channels has long been central to the understanding of acute neuronal injury. Recent studies implicate similar events in chronic neurodegenerative diseases. Here, we analyze some of the most intriguing evidence for NMDA receptor-mediated cellular dysfunction and propose a mechanism by which hyperactive NMDA receptors might lead to neurofibrillary degeneration in Alzheimer's disease.
Chohan
Muhammad Omar
MO
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314-6399, USA. Muhammad.chohan@omr.state.ny.us
Iqbal
Khalid
K
D000201:Activation Analysis / Q000379:methods; D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008559:Memantine / Q000494:pharmacology / Q000627:therapeutic use; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D016875:tau Proteins / Q000187:drug effects / Q000378:metabolism*
D000978:Antiparkinson Agents; D016194:Receptors, N-Methyl-D-Aspartate; D016875:tau Proteins; D008559:Memantine