title: Measuring disease-free survival and cancer relapse using Medicare claims from CALGB breast cancer trial participants (companion to 9344).
abstract: To determine the accuracy with which Medicare claims data measure disease-free survival in elderly Medicare beneficiaries with cancer, we performed a criterion validation study. We merged gold-standard clinical trial data of 45 elderly patients with node-positive breast cancer who were treated on the Cancer and Leukemia Group B (CALGB) adjuvant breast trial 9344 with Centers for Medicare and Medicaid Services (CMS) data files and compared the results of a CMS-based algorithm with the CALGB disease-free survival information to determine sensitivity and specificity. For 5-year disease-free survival, the sensitivity of the CMS-based algorithm was 100% (95% confidence interval [CI] = 81% to 100%), the specificity was 97% (95% CI = 83% to 100%), and the area under the receiver operator curve was 98[corrected]% (95% CI = 95[corrected]% to 100%). For 2-year disease-free survival, the test characteristics were less favorable: sensitivity was 83% (95% CI = 36% to 100%), specificity was 95% (95% CI = 83% to 100%), and area under the receiver operator curve was 89[corrected]% (95% CI = 72[corrected]% to 100%).
authors.affiliation: Massachusetts General Hospital Cancer Center and Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA, USA. lamont@hcp.med.harvard.edu
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Lamont
authors.forename: James E
authors.initials: JE
authors.lastname: Herndon
authors.forename: Jane C
authors.initials: JC
authors.lastname: Weeks
authors.forename: I Craig
authors.initials: IC
authors.lastname: Henderson
authors.forename: Craig C
authors.initials: CC
authors.lastname: Earle
authors.forename: Richard L
authors.initials: RL
authors.lastname: Schilsky
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Christakis
mesh_terms: D000368:Aged; D000465:Algorithms; D019540:Area Under Curve; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008484:Medicaid / Q000706:statistics & numerical data; D006278:Medicare / Q000706:statistics & numerical data; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000401:mortality; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014481:United States / Q000453:epidemiology