title: Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions.
authors.affiliation: Department of Chemistry and Biochemistry and The Institute of Cellular and Molecular Biology, University of Texas at Austin, 1 University Station, A5300, 78712-1167, USA.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Benfield
authors.forename: Martin G
authors.initials: MG
authors.lastname: Teresk
authors.forename: Hilary R
authors.initials: HR
authors.lastname: Plake
authors.forename: John E
authors.initials: JE
authors.lastname: DeLorbe
authors.forename: Laura E
authors.initials: LE
authors.lastname: Millspaugh
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D000595:Amino Acid Sequence; D019277:Entropy; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008024:Ligands; D011506:Proteins