title: Are microRNAs located in genomic regions associated with cancer?
abstract: We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.
authors.affiliation: Bioinformatics Research Center (BiRC), University of Aarhus, Hoegh-Guldbergs Gade 10, Bldg 1090, Aarhus C, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Lamy
authors.forename: C L
authors.initials: CL
authors.lastname: Andersen
authors.forename: L
authors.initials: L
authors.lastname: Dyrskjøt
authors.forename: N
authors.initials: N
authors.lastname: Tørring
authors.forename: T
authors.initials: T
authors.lastname: Ørntoft
authors.forename: C
authors.initials: C
authors.lastname: Wiuf
mesh_terms: D003110:Colonic Neoplasms / Q000473:pathology; D018628:Gene Dosage; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D009693:Nucleic Acid Hybridization / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis; D011471:Prostatic Neoplasms / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000235:genetics
chemical_list: D035683:MicroRNAs