Lessons learned from Art Pardee in cell cycle, science, and life.
This essay is written to honor Dr Art Pardee's 85th birthday (July 13, 2006). In this essay, I have summarized the lessons I learned from Art and the cell-cycle research I performed in Art's laboratory during my postdoctoral training period. I have also summarized some research from my own laboratory that has been inspired by the lessons I learned from Art, including the interactions between cell cycle and cell death regulators and discovery of novel polyphenol- and copper-based proteasome inhibitors. Finally, I have discussed the potential use of these proteasome inhibitors in cancer prevention and treatment.
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The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, 4100 John R. Road, Detroit, MI 48201, USA. doup@karmanos.org
D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000627:therapeutic use; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D002453:Cell Cycle / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D003300:Copper / Q000737:chemistry / Q000627:therapeutic use; D016213:Cyclins / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use; D005786:Gene Expression Regulation; D006801:Humans; D015394:Molecular Structure; D046912:Multiprotein Complexes; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control / Q000628:therapy; D010636:Phenols / Q000737:chemistry / Q000627:therapeutic use; D059808:Polyphenols; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D061988:Proteasome Inhibitors; D012108:Research Personnel; D016160:Retinoblastoma Protein / Q000378:metabolism
D016588:Anticarcinogenic Agents; D016213:Cyclins; D005419:Flavonoids; D046912:Multiprotein Complexes; D010636:Phenols; D059808:Polyphenols; D061988:Proteasome Inhibitors; D016160:Retinoblastoma Protein; D003300:Copper; D002392:Catechin; C045651:epigallocatechin gallate; D046988:Proteasome Endopeptidase Complex