Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents.
Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed.
Feng
Dennis
D
Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. dennis_feng@merck.com <dennis_feng@merck.com>
Fisher
Michael
M
Liang
Gui-Bai
GB
Qian
Xiaoxia
X
Brown
Chris
C
Gurnett
Anne
A
Leavitt
Penny Sue
PS
Liberator
Paul A
PA
Mathew
John
J
Misura
Andrew
A
Samaras
Samantha
S
Tamas
Tamas
T
Schmatz
Dennis M
DM
Wyvratt
Matthew
M
Biftu
Tesfaye
T
D000818:Animals; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004539:Eimeria / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C515886:2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo(1,2-a)pyridine; D003049:Coccidiostats; D007093:Imidazoles; D011725:Pyridines; C023666:pyridine