Organocatalytic enantioselective conjugate additions to enones.
Conjugate addition reactions of a wide range of nucleophilic enol species with enones, catalyzed by a cinchona alkaloid derived thiourea organocatalyst, have been developed with attending good yields and high enantioselectivities under a mild reaction condition. The general method provides an efficient approach to the preparation of versatile building blocks possessing various functional groups.
Wang
Jian
J
Department of Chemistry, University of New Mexico, Albuquerque, NM 87131-0001, USA.
Li
Hao
H
Zu
Liansuo
L
Jiang
Wei
W
Xie
Hexin
H
Duan
Wenhu
W
Wang
Wei
W
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
D000475:Alkenes; D004952:Esters; D007659:Ketones; D009570:Nitriles