title: Fatal granulomatous Acanthamoeba encephalitis mimicking a stroke, diagnosed by correlation of results of sequential magnetic resonance imaging, biopsy, in vitro culture, immunofluorescence analysis, and molecular analysis.
abstract: Amebic infections involving the central nervous system are rare and difficult to diagnose. Magnetic resonance imaging (MRI) at timed intervals may be helpful, where scans reveal enhancing lesions and increased signal. We report a unique case of granulomatous amebic encephalitis that was proven pathologically with progressive radiological findings on MRI.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City 84132-2405, USA. mehri.mckellar@aidshealth.org
authors.forename: Mehri S
authors.initials: MS
authors.lastname: McKellar
authors.forename: Lahar R
authors.initials: LR
authors.lastname: Mehta
authors.forename: John E
authors.initials: JE
authors.lastname: Greenlee
authors.forename: Devon C
authors.initials: DC
authors.lastname: Hale
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Booton
authors.forename: Daryl J
authors.initials: DJ
authors.lastname: Kelly
authors.forename: Paul A
authors.initials: PA
authors.lastname: Fuerst
authors.forename: Rama
authors.initials: R
authors.lastname: Sriram
authors.forename: Govinda S
authors.initials: GS
authors.lastname: Visvesvara
mesh_terms: D000048:Acanthamoeba / Q000235:genetics / Q000302:isolation & purification*; D000562:Amebiasis / Q000175:diagnosis* / Q000473:pathology; D000818:Animals; D001483:Base Sequence; D001706:Biopsy; D001921:Brain / Q000473:pathology*; D004660:Encephalitis / Q000175:diagnosis*; D005455:Fluorescent Antibody Technique; D006099:Granuloma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D020521:Stroke / Q000175:diagnosis*
chemical_list: D012337:RNA, Ribosomal, 18S