title: Moxifloxacin distribution in the interstitial space of infected decubitus ulcer tissue of patients with spinal cord injury measured by in vivo microdialysis.
abstract: We investigated the distribution of moxifloxacin in the interstitial space of normal and infected subcutaneous tissue in patients with spinal cord injury and decubitus ulcers using in vivo microdialysis. Drug concentrations achieved in serum, saliva, normal and infected tissues showed approximately parallel time profiles. The interstitial tissue fluids reached bactericidal levels for common bacteria found in infected skin lesions. Our findings suggest that moxifloxacin exhibits good and similar penetration into the interstitial space fluid in normal subcutaneous tissue and infected decubitus ulcers in patients with spinal cord injury.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA. burkhardt.olaf@mh-hannover.de
authors.forename: Olaf
authors.initials: O
authors.lastname: Burkhardt
authors.forename: Hartmut
authors.initials: H
authors.lastname: Derendorf
authors.forename: Doris
authors.initials: D
authors.lastname: Jäger
authors.forename: Vipul
authors.initials: V
authors.lastname: Kumar
authors.forename: Rajanikanth
authors.initials: R
authors.lastname: Madabushi
authors.forename: Klaus
authors.initials: K
authors.lastname: Röhl
authors.forename: Jürgen
authors.initials: J
authors.lastname: Barth
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001372:Aza Compounds / Q000097:blood / Q000493:pharmacokinetics*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D017551:Microdialysis / Q000379:methods; D008875:Middle Aged; D000077266:Moxifloxacin; D003668:Pressure Ulcer / Q000209:etiology / Q000378:metabolism*; D011804:Quinolines / Q000097:blood / Q000493:pharmacokinetics*; D013119:Spinal Cord Injuries / Q000150:complications*; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin