title: [Reversed phase high-performance liquid chromatography for determination of plasma olanzapine and pharmacokinetics of olanzapine in healthy Chinese volunteers].
abstract: OBJECTIVE
  To establish a reversed phase high-performance liquid chromatography (HPLC) system for determining plasma concentration of olanzapine and analyze the pharmacokinetics of olanzapine in healthy Chinese volunteers.
  
  
  METHODS
  Ten healthy male subjects received a single oral dose of 20 mg olanzapine tablets. The plasma concentrations of olanzapine were determined by HPLC, and the data were analyzed using 3P97 program.
  
  
  RESULTS
  The plasma concentration curve of olanzapine following a single oral dose conformed to the two compartment open model. The main pharmacokinetics parameters of olanzapine were as follow: C(max) was 113.7-/+33.1 microg/L, T(max) 5.07-/+0.65 h, t(1/2) 35.44-/+4.21 h, AUC(0-144) 2,235-/+257 microg.h.L(-1), and AUC(0-inf) 2,516-/+301 microg.h.L(-1).
  
  
  CONCLUSIONS
  The system established in this study allows for highly sensitive, selective and accurate determination of plasma concentration of olanzapine, and provides valuable information for clinical trials.
authors.affiliation: Department of Pharmacy, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China. dropwatercat@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Wei-zhong
authors.initials: WZ
authors.lastname: Liu
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000097:blood / Q000493:pharmacokinetics; D019540:Area Under Curve; D001569:Benzodiazepines / Q000097:blood* / Q000493:pharmacokinetics*; D002681:China; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D008297:Male; D000077152:Olanzapine; D015203:Reproducibility of Results
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine