title: The COPII cage: unifying principles of vesicle coat assembly.
abstract: Communication between compartments of the exocytic and endocytic pathways in eukaryotic cells involves transport carriers - vesicles and tubules - that mediate the vectorial movement of cargo. Recent studies of transport-carrier formation in the early secretory pathway have provided new insights into the mechanisms of cargo selection by coat protein complex-II (COPII) adaptor proteins, the construction of cage-protein scaffolds and fission. These studies are beginning to produce a unifying molecular and structural model of coat function in the formation and fission of vesicles and tubules in endomembrane traffic.
authors.affiliation: Department of Electron Microscopy and Molecular Pathology, the Cyprus Institute of Neurology and Genetics, International Airport Avenue #6, Agios Dometios, 1683, Nicosia, Cyprus.
authors.forename: Cemal
authors.initials: C
authors.lastname: Gürkan
authors.forename: Scott M
authors.initials: SM
authors.lastname: Stagg
authors.forename: Paul
authors.initials: P
authors.lastname: Lapointe
authors.forename: William E
authors.initials: WE
authors.lastname: Balch
mesh_terms: D000818:Animals; D001692:Biological Transport; D022181:COP-Coated Vesicles / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000648:ultrastructure; D019143:Evolution, Molecular; D005544:Forecasting; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D033921:Vesicular Transport Proteins