title: In vitro susceptibility of breakthrough Candida bloodstream isolates correlates with daily and cumulative doses of fluconazole.
abstract: We determined MICs for 28 Candida isolates recovered from patients who developed breakthrough candidemia while receiving fluconazole. MICs correlated with daily and cumulative doses of fluconazole. Patients receiving > or =2,000 mg cumulatively or >200 mg daily were more likely to be infected with isolates that were not fluconazole susceptible.
authors.affiliation: University of Florida College of Medicine, Department of Medicine, Gainesville, FL 32610, USA. clancyn@medicine.ufl.edu
authors.forename: Cornelius J
authors.initials: CJ
authors.lastname: Clancy
authors.forename: Benjamin
authors.initials: B
authors.lastname: Staley
authors.forename: M Hong
authors.initials: MH
authors.lastname: Nguyen
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001769:Blood / Q000382:microbiology; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D018890:Chemoprevention; D015725:Fluconazole / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole