Paraneoplastic cerebellar degeneration: Yo-expressing tumor revealed after a 5-year follow-up with FDG-PET.
We report a patient with anti-Yo associated paraneoplastic cerebellar degeneration (PCD) whose tumor was demonstrated 5 years after developing PCD and had strong expression of Yo (cdr2) antigen. Review of this case along with clinical series and studies of tumor growth rates question the effectiveness of the anti-tumor immune response. These studies and similar cases suggest that the tumor may trigger the anti-Yo immune response at microscopic stages of development. An overwhelming majority of anti-Yo positive patients eventually develop a detectable malignancy, which argues in favor of a poorly effective or non-sustained anti-tumor immune response.
Mathew
Rose Marie
RM
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States.
Cohen
Adam B
AB
Galetta
Steven L
SL
Alavi
Abass
A
Dalmau
Josep
J
D014408:Biomarkers, Tumor / Q000276:immunology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology* / Q000503:physiopathology; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000276:immunology* / Q000503:physiopathology; D002531:Cerebellum / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000276:immunology*; D020362:Paraneoplastic Cerebellar Degeneration / Q000276:immunology* / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000592:standards; D021701:Sentinel Lymph Node Biopsy; D013997:Time Factors
D014408:Biomarkers, Tumor; C095184:CDR2 protein, human; D009419:Nerve Tissue Proteins; D019788:Fluorodeoxyglucose F18