title: Leptin infusion during the early luteal phase in ewes does not affect progesterone production.
abstract: Infusion of leptin during the ovine follicular phase has been shown to increase progesterone secretion during the subsequent luteal phase. In this study, we have assessed the effects of infusing leptin during the early luteal phase. Infusion of leptin (2.5 microg/h) into the ovarian artery of ewes with ovarian autotransplants (n=5) on day 3 of the luteal phase for 12h did not affect progesterone estradiol or LH concentrations compared to control ewes (n=5). These results suggest no direct effect of leptin on ovarian function at this stage of the estrous cycle.
authors.affiliation: Division of Animal Physiology, University of Nottingham, Sutton Bonington Campus, Loughborough, UK.
authors.forename: L T
authors.initials: LT
authors.lastname: Nicklin
authors.forename: R S
authors.initials: RS
authors.lastname: Robinson
authors.forename: B K
authors.initials: BK
authors.lastname: Campbell
authors.forename: M G
authors.initials: MG
authors.lastname: Hunter
authors.forename: G E
authors.initials: GE
authors.lastname: Mann
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D020738:Leptin / Q000502:physiology*; D007986:Luteinizing Hormone / Q000378:metabolism; D010060:Ovulation / Q000502:physiology*; D011374:Progesterone / Q000378:metabolism*; D012756:Sheep / Q000097:blood*
chemical_list: D020738:Leptin; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone