title: Comparison of regional cerebral blood flow in two subsets of subcortical ischemic vascular dementia: statistical parametric mapping analysis of SPECT.
abstract: BACKGROUND
  The brain imaging criteria for subcortical ischemic vascular dementia (SIVD), as proposed by Erkinjuntti, incorporated two clinical entities, the lacunar state and Binswanger's disease. However it has not been proven whether these two subtypes of SIVD have common pathophysiological features. This study investigated the changes of regional cerebral blood flow (CBF) in the two subsets of SIVD to establish whether these two subtypes could be incorporated into the same group for the purpose of conducting clinical trials.
  
  
  METHODS
  Twelve SIVD patients with predominant white matter lesions, 13 patients with predominant lacunar infarctions and 17 controls were evaluated. Single photon emission computed tomography (SPECT) was performed to measure the regional CBF, and statistical parametric mapping (SPM) was applied to the analysis of the SPECT data.
  
  
  RESULTS
  The normalized CBF (nCBF) in the bilateral thalami, the anterior cingulate gyri, the superior temporal gyri, the caudate heads and the left parahippocampal gyrus was significantly decreased in the SIVD patients compared to the controls. This pattern of nCBF reduction was same in both the two subtypes of SIVD patients.
  
  
  CONCLUSIONS
  Our study suggests that the two subsets of SIVD may have a common nCBF abnormality, and Erkinjuntti's criteria offer a solution for researchers to identify the more homogeneous group of vascular dementia patients.
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, 62 Youido-dong, Yeongdeungpo-gu, Seoul 150-713, South Korea.
authors.forename: Yong S
authors.initials: YS
authors.lastname: Shim
authors.forename: Dong-Won
authors.initials: DW
authors.lastname: Yang
authors.forename: Beum-Saeng
authors.initials: BS
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Shon
authors.forename: Yong-An
authors.initials: YA
authors.lastname: Chung
mesh_terms: D000368:Aged; D020520:Brain Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003627:Data Interpretation, Statistical; D015140:Dementia, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D011237:Predictive Value of Tests; D013687:Telencephalon / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*