Protection from autoimmunity by DNA vaccination against T-cell receptor.
T-lymphocytes are essential participants of adaptive immunity, essential for cellular and humoral recognition of foreign antigens. In pathogenic situations T cells may, however, also recognize self-antigens, causing detrimental autoimmune responses that ultimately lead to autoimmune disease. Experimental autoimmune encephalomyelitis (EAE) is a murine model for the autoimmune disease multiple sclerosis, in which T cells invade the central nervous system and destroy the myelin sheath around neuronal axon fibers. In some EAE systems, the sequence of the alpha- or beta-chains of the pathogenic T-cell receptor is known and makes it possible to induce an immune response that eliminates these self-specific T cells. Herein we describe a method, using DNA vaccination that allows induction of such an immune response to protect mice from the development of EAE.
Buch
Thorsten
T
Institute of Genetics, University of Cologne, Cologne, Germany.
Waisman
Ari
A
D000818:Animals; D001324:Autoantigens / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity / Q000187:drug effects / Q000235:genetics; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology*; D014611:Vaccination; D019444:Vaccines, DNA / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology
D001324:Autoantigens; D016693:Receptors, Antigen, T-Cell, alpha-beta; D019444:Vaccines, DNA