Testing for renewal and detailed balance violations in single-molecule blinking processes.
This paper examines methods to test one- and two-dimensional histograms for several features including the renewal properties, detailed balance violations, and experimental condition dependences. The tests are simple to implement and allow rigorous statistical determination of the existence of these kinetic features. The tests are used to determine the lower bound on the number of measurements necessary to differentiate underlying kinetic models.
Witkoskie
James B
JB
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Cao
Jianshu
J