title: Follicular lymphoma frequently originates in the salivary gland.
abstract: The aim of the present study was to examine the clinicopathological presentations of follicular lymphomas (FL) of the salivary glands, as compared to mucosa-associated lymphoid tissue (MALT) lymphomas. A total of 27 primary salivary gland lymphomas were examined: 6 FL (five, grade 1; one, grade 2); 19 MALT lymphomas; and two diffuse large B-cell lymphomas. The FL patients ranged in age from 24 to 73 years, with a mean of 49 years, which was younger than that of MALT patients (mean: 64 years; P < 0.05). Four of the six FL arose from the submandibular gland, which was the origin of only five out of a total of 19 MALT lymphomas. One FL patient was in clinical stage (CS) IE, two in CS IIE, and two in CS III and IV. As regards the MALT lymphoma patients, 13 (68%) were in CS IE and five (26%) in CS IIE. None of the FL patients had clinical diagnosis of autoimmune disease but eight MALT lymphoma patients had autoimmune disease. The present study found a relatively high incidence of FL in the salivary glands. The observed differences in age of onset, background of autoimmune disease, and lesion site suggests that the pathogenesis of FL may differ from that of MALT lymphoma.
authors.affiliation: Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakamura
authors.forename: Koichi
authors.initials: K
authors.lastname: Ichimura
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Sato
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nakamine
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inagaki
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Sadahira
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Sumie
authors.initials: S
authors.lastname: Sakugawa
authors.forename: Eisaku
authors.initials: E
authors.lastname: Kondo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yanai
authors.forename: Nobuya
authors.initials: N
authors.lastname: Ohara
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001327:Autoimmune Diseases; D051925:CD79 Antigens / Q000235:genetics / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008224:Lymphoma, Follicular / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000235:genetics / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D012469:Salivary Glands / Q000378:metabolism / Q000473:pathology*
chemical_list: C415943:API2-MALT1 fusion protein, human; D051925:CD79 Antigens; D015514:Oncogene Proteins, Fusion; D019253:Proto-Oncogene Proteins c-bcl-2; D015260:Neprilysin