title: Prenatal diagnosis and multidisciplinary approach to the congenital gingival granular cell tumor.
abstract: OBJECTIVE
  Congenital gingival granular cell tumor (CGCT) is a rare benign lesion appearing at birth on the alveolar median ridge of the maxilla. Etiology is still unclear because spontaneous regression of the lesion is rare.
  
  
  METHODS
  The present report describes 2 cases of neonatal CGCT, highlighting benefits of ultrasonography to treatment of the prenatally diagnosed lesion.
  
  
  RESULTS
  The patients immediately underwent surgical exeresis. Pathology revealed a tumor of large polyedric cells with vacuolar central nuclei and eosinophil granular cytoplasm.
  
  
  CONCLUSIONS
  Prenatal diagnosis is fundamental in the therapeutic approach to CGCT: ultrasonography methodologies allow diagnosis of the lesion in the uterus at the 36th gestational week, thus also allowing planning of delivery and, immediately later, the surgical treatment. That permits planning of delivery in a third-level center with considerable benefit for both the mother and the newborn.
authors.affiliation: Section of Pediatric Surgery, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico Le Scotte, 53100 Siena, Italy. messinam@unisi.it
authors.forename: Mario
authors.initials: M
authors.lastname: Messina
authors.forename: Filiberto M
authors.initials: FM
authors.lastname: Severi
authors.forename: Guiseppe
authors.initials: G
authors.lastname: Buonocore
authors.forename: Francesco
authors.initials: F
authors.lastname: Molinaro
authors.forename: Giovanna
authors.initials: G
authors.lastname: Amato
authors.forename: Felice
authors.initials: F
authors.lastname: Petraglia
mesh_terms: D005260:Female; D005887:Gingival Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D016586:Granular Cell Tumor / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010348:Patient Care Team; D016216:Ultrasonography, Prenatal