title: High dose calcitriol may reduce thrombosis in cancer patients.
abstract: The incidence of venous and arterial thrombosis in a placebo-controlled randomised trial of DN-101 (high dose calcitriol) with docetaxel versus docetaxel was compared. Of the 13 thrombotic events observed in the 250 patients enroled in this study, two occurred in DN-101 and 11 in placebo-treated patients (P = 0.01). This difference remained significant after adjustment for baseline history of thrombosis, atrial fibrillation and use of anti-thrombotic agents. In vitro and vitamin D receptor (VDR) knockout mouse studies predict that nanomolar concentrations of calcitriol may act as an antithrombotic agent. We report the first clinical observation that supports this hypothesis in humans.
authors.affiliation: Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR 97239, USA. beert@ohsu.edu
authors.forename: Tomasz M
authors.initials: TM
authors.lastname: Beer
authors.forename: Peter M
authors.initials: PM
authors.lastname: Venner
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Ryan
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Petrylak
authors.forename: Gurkamal
authors.initials: G
authors.lastname: Chatta
authors.forename: J
authors.initials: J
authors.lastname: Dean Ruether
authors.forename: Kim N
authors.initials: KN
authors.lastname: Chi
authors.forename: John G
authors.initials: JG
authors.lastname: Curd
authors.forename: Thomas G
authors.initials: TG
authors.lastname: DeLoughery
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D001158:Arteries; D002117:Calcitriol / Q000008:administration & dosage*; D000077143:Docetaxel; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications*; D043823:Taxoids / Q000008:administration & dosage; D013927:Thrombosis / Q000517:prevention & control*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000517:prevention & control
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005343:Fibrinolytic Agents; D043823:Taxoids; D000077143:Docetaxel; D002117:Calcitriol