title: Evidence that trait-anxiety and trait-depression differentially moderate cortical processing of pain.
abstract: OBJECTIVE
  The purpose of this study was to examine the influence of neuroticism (N) and its different subfacets anxiety (N-anx) and depression (N-dep) on cortical pain processing expressed as event-related potentials (ERPs).
  
  
  METHODS
  Seventy-five healthy participants received electrical pain stimuli under condition of simultaneous electroencephalogram registration. Multiple regression analyses were conducted to study the amount of pain-ERP variance. ERP variance was explained by N and its subfacets.
  
  
  RESULTS
  N moderated the way pain was processed cortically. Higher levels of N were associated with higher pain-ERP amplitudes. Within this association, differential subfacet effects were observed: N-anx reduced, whereas N-dep augmented pain-ERP amplitudes.
  
  
  CONCLUSIONS
  A personality trait reflecting bias toward negative emotions may moderate the way pain is processed cortically, with directionally different effects depending on whether the trait is expressed predominantly in the realm of anxiety or depression.
authors.affiliation: Roessingh Research and Development, Enschede, UK. vossen@np.unimaas.nl
authors.forename: Helen G M
authors.initials: HG
authors.lastname: Vossen
authors.forename: Jim
authors.initials: J
authors.lastname: van Os
authors.forename: Hermie
authors.initials: H
authors.lastname: Hermens
authors.forename: Richel
authors.initials: R
authors.lastname: Lousberg
mesh_terms: D000222:Adaptation, Physiological; D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D003863:Depression / Q000503:physiopathology*; D019317:Evidence-Based Medicine; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017288:Pain Threshold / Q000502:physiology*