qnrA in CTX-M-producing Escherichia coli isolates from France.
By PCR, we screened for qnr genes 112 clinical isolates of extended-spectrum beta-lactamase-producing Escherichia coli collected from hospitals in France during 2004. For the first time, 7.7% of CTX-M-producing E. coli isolates presented a plasmid-mediated resistance to quinolones. All strains harbored a qnrA gene located on a sul1-type class 1 integron with similar structure to the In36 integron.
Lavigne
Jean-Philippe
JP
Laboratoire Universitaire d'Antibiologie, UFR de Médecine, Avenue Kennedy, 30908 Nîmes Cedex 02, France.
Marchandin
Hélène
H
Delmas
Julien
J
Bouziges
Nicole
N
Lecaillon
Evelyne
E
Cavalie
Laurent
L
Jean-Pierre
Hélène
H
Bonnet
Richard
R
Sotto
Albert
A
D000890:Anti-Infective Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification*; D005602:France; D005798:Genes, Bacterial; D032023:Integrons; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction; D015363:Quinolones / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis*
D000890:Anti-Infective Agents; D015363:Quinolones; D009268:Nalidixic Acid; D001618:beta-Lactamases