Abnormal expansion of naïve B lymphocytes after unrelated cord blood transplantation--a case report.
A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19+ B cells in bone marrow and CD19+27-IgD+ B cells in peripheral blood from about 1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19+ B cells. Although, compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U-CBT, there was initial B-cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B-cell precursors present in cord blood (CB). The phenomenon of naïve B lymphocyte expansion that we found might be associated with a high number of B-cell precursors present in CB.
Shono
Y
Y
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan.
Toubai
T
T
Ota
S
S
Ibata
M
M
Mashiko
S
S
Hirate
D
D
Miura
Y
Y
Umehara
S
S
Toyoshima
N
N
Tanaka
J
J
Asaka
M
M
Imamura
M
M
D000328:Adult; D016175:B-Lymphocyte Subsets / Q000145:classification* / Q000166:cytology; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D005260:Female; D006085:Graft Survival; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008213:Lymphocyte Activation / Q000276:immunology; D009190:Myelodysplastic Syndromes / Q000628:therapy; D014184:Transplantation, Homologous