Postnatal - physiological research of the bronchial receptor system development on the isolated preparation of the human trachea in vitro.
Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children. Monitored was the response on: acetylcholine, dopamine, histamine and serotonin in different molar concentrations 10(-4), 10(-3), 10(-2), 10 mol/dm(-3), micromol/dm(-3)). Research was done on tonus of tracheal smooth muscles of 23 tracheal preparations taken by autopsy after death from different factors. Based on pharmacological-physiological research on the preparations of human isolated trachea it was find out that: acetylcholine stimulation effect is significant (p>0,01) in 38-41 weeks of pregnancy comparing with that in 30-37 weeks of pregnancy (p>0,01), while dopamine stimulation effect is significant (p>0,05) in 30-37 pregnancy weeks comparing with the effect of acetylcholine and dopamine on the still-born infants of the same pregnancy period (p<0,01). Histaminic receptors were developed during intrauterine life after 38 weeks of pregnancy (p>0,025). Serotonin has caused contraction of the bronchial smooth muscles after 30 pregnancy weeks, but response was not significant (p<0,01). This suggests that cholinergic and adrenergic system of the airways in alive newborn infants develops in parallel intrauterine, contrary to other systems which develop in certain extrauterine life phases.
Sukalo
Aziz
A
Bosnalijek-Pharmaceutical Company - Sarajevo, Bosnia and Herzegovina.
Islami
Hilmi
H
Shabani
Ragib
R
Dauti
Hilmi
H
Kutllovci
Skender
S
Kastrati
Bashkim
B
D000109:Acetylcholine / Q000378:metabolism; D001980:Bronchi / Q000254:growth & development / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006632:Histamine / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009130:Muscle, Smooth / Q000378:metabolism*; D011247:Pregnancy; D017982:Receptors, Biogenic Amine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D014132:Trachea / Q000254:growth & development* / Q000378:metabolism*
D017982:Receptors, Biogenic Amine; D012701:Serotonin; D006632:Histamine; D000109:Acetylcholine; D004298:Dopamine