Experimental coccidiosis provoked by Eimeria acervulina in chicks simultaneously fed on ochratoxin A contaminated diet.
The progression of coccidiosis provoked by Eimeria acervulina was followed in chicks fed on OTA-contaminated as well as on OTA-free diets. More heavy progress of duodenal coccidiosis, including mortality, occurred in OTA-treated chicks as can be seen from the higher value of lesion (3.50) and oocyst (31.65) indices. A stronger decrease of serum total protein was found in OTA-treated chicks (22.80 g/l) than in chicks infected with E. acervulina(24.20 g/l), but that decrease was strongest in chicks treated with OTA and simultaneously infected with E. acervulina (19.71 g/l). The serum concentration of uric acid was significantly increased in all chicks exposed to OTA, most notably in those additionally infected with E. acervulina (1020.6 (micro mol/L), whereas the serum enzyme activity of AST was increased only in chicks infected with E. acervulina and highest in those fed OTA contaminated diet (122.2 U/L). OTA induced degenerative changes in kidneys, liver and heart as well as a depletion of lymphoid tissue in the lymphoid organs and a decrease of body weight. Coccidiosis induced only a slight growth depression and duodenal hemorrhages in addition to characteristic duodenal damages. The impairment of kidney function, histopathological changes and general growth depression were stronger when chicks infected with E. acervulina were also given OTA.
Koynarski
V
V
Department of Parasitology, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria.
Stoev
S
S
Grozeva
N
N
Mirtcheva
T
T
Daskalov
H
H
Mitev
J
J
Mantle
P
P
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight; D002060:Bursa of Fabricius / Q000469:parasitology / Q000473:pathology; D002531:Cerebellum / Q000469:parasitology / Q000473:pathology; D002645:Chickens; D003048:Coccidiosis / Q000378:metabolism / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D004539:Eimeria / Q000254:growth & development*; D005506:Food Contamination; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000469:parasitology / Q000473:pathology; D007668:Kidney / Q000469:parasitology / Q000473:pathology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D009793:Ochratoxins / Q000008:administration & dosage* / Q000378:metabolism; D011201:Poultry Diseases / Q000378:metabolism / Q000469:parasitology* / Q000473:pathology; D013047:Specific Pathogen-Free Organisms; D018709:Statistics, Nonparametric; D014527:Uric Acid / Q000097:blood
D009793:Ochratoxins; C025589:ochratoxin A; D014527:Uric Acid; D001219:Aspartate Aminotransferases