-765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia.
OBJECTIVE
To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma.


METHODS
A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method.


RESULTS
-765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).


CONCLUSIONS
-765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.
Pereira
Carina
C
Serviço de Gastrenterologia, Instituto Português de Oncologia do Porto FG EPE, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal.
Sousa
Hugo
H
Ferreira
Paula
P
Fragoso
Maria
M
Moreira-Dias
Luís
L
Lopes
Carlos
C
Medeiros
Rui
R
Dinis-Ribeiro
Mário
M
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000483:Alleles; D001284:Atrophy / Q000235:genetics / Q000473:pathology; D003430:Cross-Sectional Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D003553:Cystine / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006147:Guanine / Q000032:analysis; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008679:Metaplasia / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011174:Portugal; D012044:Regression Analysis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
D004273:DNA, Neoplasm; D008565:Membrane Proteins; D003553:Cystine; D006147:Guanine; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human