title: T-cell type lymphoproliferative disease of granular lymphocytes (LDGL) is equipped with a phenotypic pattern typical of effector cytotoxic cells.
abstract: By analyzing the expression of several cytotoxic markers, killer-immunoglobulin-like receptors (KIRs), CD94/CD159, CD314 and natural cytotoxicity receptors (NCRs), in 22 CD3+ lymphoproliferative disease of granular lymphocyte (LDGL) patients we investigated whether granular lymphocytes (GLs) displayed the phenotype of fully differentiated cytotoxic cells. Our results demonstrate that GLs express a pattern consistent with fully differentiated CTLs. KIRs are expressed only in a fraction of patients (7/22), as is CD94/CD159 (5/22). In conclusion, GLs in CD3+ LDGL patients typically show the phenotype of fully differentiated CTL, whereas the expression of NK receptors does not represent a common feature of the proliferating clone.
authors.affiliation: Padua University School of Medicine, Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch, University of Padua, Italy.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Baesso
authors.forename: Laura
authors.initials: L
authors.lastname: Pavan
authors.forename: Elisa
authors.initials: E
authors.lastname: Boscaro
authors.forename: Marta
authors.initials: M
authors.lastname: Miorin
authors.forename: Monica
authors.initials: M
authors.lastname: Facco
authors.forename: Livio
authors.initials: L
authors.lastname: Trentin
authors.forename: Carlo
authors.initials: C
authors.lastname: Agostini
authors.forename: Renato
authors.initials: R
authors.lastname: Zambello
authors.forename: Gianpietro
authors.initials: G
authors.lastname: Semenzato
mesh_terms: D000368:Aged; D017252:CD3 Complex / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008214:Lymphocytes / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D008297:Male; D055655:NK Cell Lectin-Like Receptor Subfamily K; D017452:Receptors, IgG / Q000276:immunology; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000276:immunology; D054340:Receptors, KIR; D055607:Receptors, Natural Killer Cell; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D017252:CD3 Complex; C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D055607:Receptors, Natural Killer Cell