title: Synthesis of macrosphelides with a thiazole side chain: new antitumor candidates having apoptosis-inducing property.
abstract: Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy. Some of these hybrids were found to exhibit notable apoptosis-inducing activity against human lymphoma cells with higher potency than parent natural macrosphelides, and to be a promising lead compound for development of a new antitumor agent.
authors.affiliation: Faculty of Pharmaceutical Sciences, and Department of Radiological Sciences, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuya
authors.forename: Takanori
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ishihara
authors.forename: Kanwal
authors.initials: K
authors.lastname: Ahmed
authors.forename: Qing-Li
authors.initials: QL
authors.lastname: Zhao
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Hideo
authors.initials: H
authors.lastname: Nemoto
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D013844:Thiazoles