Genomic copy-number aberrations related to lymph-node metastasis of colon cancer.
Lymph-node metastasis is an important indicator in the diagnosis of colon cancer. In order to determine the genes involved in metastasis, genomic copy-number aberrations in the primary tumours and lymph-node metastases were analysed in 12 patients using comparative genomic hybridization. This method detects genomic copy-number changes at the chromosomal level and the identification of the regions of aberration on any chromosome. Copy-number gains at 6p12 and losses at 8p12 were observed in a greater number of the primary tumours than in the metastases. These aberrations appear to be involved in lymph-node metastasis of colon cancer, and may allow measurement of the risk of lymph-node metastasis from a given colon cancer.
Yaginuma
Y
Y
Department of Coloproctological Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Unotoro
J
J
Kamiyama
H
H
Ishido
Y
Y
Kasamaki
S
S
Sakamoto
K
K
Shindo
T
T
Ishibasi
Y
Y
Kamano
T
T
D000230:Adenocarcinoma / Q000235:genetics* / Q000556:secondary / Q000601:surgery; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005784:Gene Amplification; D018628:Gene Dosage; D016678:Genome; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D008297:Male; D009693:Nucleic Acid Hybridization
D004273:DNA, Neoplasm