title: Rubeosis and anterior segment ischemia associated with systemic cryoglobulinemia.
abstract: OBJECTIVE
  To report two cases of iris neovascularization associated with systemic cryoglobulinemia.
  
  
  METHODS
  Retrospective case report.
  
  
  METHODS
  Patient chart review and review of literature.
  
  
  RESULTS
  Two patients with iris neovascularization in the absence of retinal ischemia were subsequently found to have systemic cryoglobulinemia. Successful treatment of one patient's underlying lymphoma led to stabilization and resolution of neovascularization.
  
  
  CONCLUSIONS
  Systemic cryoglobulinemia may be associated with anterior segment ischemia and neovascularization, and should be considered in the differential diagnosis of iris neovascularization in the absence of apparent retinal ischemia.
authors.affiliation: Ocular Inflammatory Disease Center, Jules Stein Eye Institute, and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: David G
authors.initials: DG
authors.lastname: Telander
authors.forename: Gary N
authors.initials: GN
authors.lastname: Holland
authors.forename: Martin B
authors.initials: MB
authors.lastname: Wax
authors.forename: Russell N
authors.initials: RN
authors.lastname: Van Gelder
mesh_terms: D000328:Adult; D000869:Anterior Eye Segment / Q000098:blood supply*; D001284:Atrophy; D003449:Cryoglobulinemia / Q000150:complications*; D015355:Glaucoma, Neovascular / Q000209:etiology; D006801:Humans; D007498:Iris / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000209:etiology*; D009389:Neovascularization, Pathologic / Q000209:etiology*; D012189:Retrospective Studies