A one-sided view of kinetochore attachment in meiosis.
Meiosis includes a reductional division in which homologous chromosomes, rather than sister chromatids, are segregated to opposite poles of the spindle. In this issue of Cell, report that casein kinase 1 contributes to this process by promoting the attachment of both kinetochores of a homolog to only one pole of the meiotic spindle in budding yeast.
Watanabe
Yoshinori
Y
Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan. ywatanab@iam.u-tokyo.ac.jp <ywatanab@iam.u-tokyo.ac.jp>
D047389:Casein Kinase I / Q000235:genetics / Q000378:metabolism*; D016764:Cell Polarity / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology*; D018386:Kinetochores / Q000378:metabolism* / Q000648:ultrastructure; D008540:Meiosis / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D008941:Spindle Apparatus / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure
D002868:Chromosomal Proteins, Non-Histone; C502898:REC8 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D047389:Casein Kinase I; C070775:HRR25 protein, S cerevisiae