Synthesis and PKC binding of a new class of a-ring diversifiable bryostatin analogues utilizing a double asymmetric hydrogenation and cross-coupling strategy.
The design, asymmetric synthesis, and biological evaluation of a new class of bryostatin analogues based on a pseudosymmetric spacer domain are described. An aryl bromide diversification site is incorporated allowing access to systematically varied analogues. The new analogues all exhibit potent, nanomolar affinity to PKC.
Wender
Paul A
PA
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu
Horan
Joshua C
JC
D054713:Bryostatins; D006859:Hydrogen / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D011493:Protein Kinase C / Q000378:metabolism*
D054713:Bryostatins; D018942:Macrolides; C046785:bryostatin 1; D006859:Hydrogen; D011493:Protein Kinase C