title: Association of selective HLA class II susceptibility-conferring and protective haplotypes with type 2 diabetes in patients from Bahrain and Lebanon.
abstract: The association of HLA class II with type 2 diabetes (T2DM) was investigated in Bahraini and Lebanese subjects. DRB1*070101 (Lebanese and Bahraini) and DQB1*0201 (Lebanese) were susceptibility-conferring alleles, and unique susceptibility-conferring/protective haplotypes were found in both patient groups. Regression analysis confirmed that DRB1*070101-DQB1*0201 (Bahraini) and DRB1*110101-DQB1*0201 (Lebanese) were susceptibility-conferring haplotypes.
authors.affiliation: Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. wyalmawi@yahoo.co.uk
authors.forename: Wassim Y
authors.initials: WY
authors.lastname: Almawi
authors.forename: Saria F
authors.initials: SF
authors.lastname: Wakim-Ghorayeb
authors.forename: Mona R
authors.initials: MR
authors.lastname: Arekat
authors.forename: Pierre
authors.initials: P
authors.lastname: Najm
authors.forename: Sose H
authors.initials: SH
authors.lastname: Keleshian
authors.forename: Nasreen
authors.initials: N
authors.lastname: Al-Sayed
authors.forename: Bruno
authors.initials: B
authors.lastname: Blanchon
authors.forename: Hanady R
authors.initials: HR
authors.lastname: Samaha
authors.forename: Noha
authors.initials: N
authors.lastname: Irani-Hakime
mesh_terms: D000483:Alleles; D001445:Bahrain; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D007861:Lebanon; D008297:Male; D008875:Middle Aged
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen