[Therapeutic possibilities of probiotics in antibiotic-related diarrhea].
One of the major problems associated with the use of antibiotics is the occurrence of antibiotic-related diarrhea. Although most such cases of diarrhea are harmless, in individual cases it may lead on to fulminant colitis. In 10-20% of the patients, the causal factor is infection with Clostridium difficile, which multiplies unhindered in patients on antibiotics. In the meantime, controlled, randomized studies have shown that probiotics can exercise a preventive effect in antibiotic-related diarrhea. The administration of Saccharomyces boulardii or Lactobacillus rhamnosus GG reduces the relative risk of an antibiotic-related diarrhea developing by 0.5. The data are more uniform in children than in adults.
Krämer
S
S
Lehrstuhl für Ernährungsmedizin/Prävention, Universität Hohenheim. kraemers@uni-hohenheim.de
Bischoff
S C
SC
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D016360:Clostridioides difficile / Q000302:isolation & purification; D003967:Diarrhea / Q000139:chemically induced / Q000628:therapy*; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology / Q000628:therapy*; D006801:Humans; D007223:Infant; D052201:Lacticaseibacillus rhamnosus; D010919:Placebos; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012306:Risk; D012440:Saccharomyces
D000900:Anti-Bacterial Agents; D010919:Placebos