ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients.
Amyloid beta is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene, encoding for P-gp, is highly polymorphic and this may result in a changed function of P-gp and may possibly interfere with the pathogenesis of Alzheimer's disease. This study investigates to what extent ABCB1 Single Nucleotide Polymorphisms (SNPs; C1236T in exon 12, G2677T/A in exon 21 and C3435T in exon 26) and inferred haplotypes exist in an elderly population and if these SNPs and haplotypes differ between patients with dementia and age-matched non-demented control patients. ABCB1 genotype, allele and haplotype frequencies were neither significantly different between patients with dementia and age-matched controls, nor between subgroups of different types of dementia nor age-matched controls. This study shows ABCB1 genotype frequencies to be comparable with described younger populations. To our knowledge this is the first study on ABCB1 genotypes in dementia. ABCB1 genotypes are presently not useful as a biomarker for dementia, as they were not significantly different between demented patients and age-matched control subjects.
Frankfort
Suzanne V
SV
Department of Geriatric Medicine, Slotervaart Hospital, Amsterdam, The Netherlands. apsfr@slz.nl
Doodeman
Valerie D
VD
Bakker
Remco
R
Tulner
Linda R
LR
van Campen
Jos P C M
JP
Smits
Paul H M
PH
Beijnen
Jos H
JH