Immunoscintigraphy of colorectal carcinomas with radiolabeled monoclonal antibody fragments.
OBJECTIVE
The aim was evaluation of the accuracy and clinical impact of the immunoscintigraphy for the detection of metastases and recurrences of colorectal carcinomas using two different radiolabeled antibody fragments.


METHODS
The study was performed in 5 patients with IMACIS 1 containing the cocktail of 111MBq 131I MoAb 19-9 F(ab')2 and MoAb anti-CEA F(ab')2 and 8 patients with INDIMACIS 19-9 containing 150MBq of 111In-labeled MoAb 19-9 F(ab')2.


RESULTS
With IMACIS 1, in all the patients, both tumor marker values were elevated. The number of TN was 3/5 and TP 2/5. From 2 TP, one had recurrence of the diseases with peritoneal carcinosis and one with liver metastases. In one patient, the results influenced the therapeutical management. With INDIMACIS 19-9, there were 2/8 TN, with borderline value of CEA and CA 19-9. TP were 6/8 (all with elevated tumor marker values, five of them many times; 3 with recurrences, 1 with recurrence and liver metastases and two with only liver metastases. In three patients, immunoscintigraphy influenced patient management.


CONCLUSIONS
With both radiopharmaceuticals, immunoscintigraphy significantly influenced the patient management or it was complementary. It would be performed in the detection of recurrence, assessment of viability and follow-up of the therapy.
Obradovic
Vladimir
V
Institute for Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia, & Montenegro. vladimir.obradovic@kcs.ac.yu
Artiko
Vera
V
Petrovic
Milorad
M
Stefanovic
Branislav
B
Krivokapic
Zoran
Z
Zuvela
Marinko
M
Stojkovic
Mirjana
M
Stefanovic
Branislava
B
Milovanovic
Aleksandar
A
Vlajkovic
Marina
M
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000911:Antibodies, Monoclonal; D018395:CA-19-9 Antigen / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000276:immunology; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D016719:Radioimmunodetection / Q000379:methods*
D000911:Antibodies, Monoclonal; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; C057468:Imacis-1; D007140:Immunoglobulin Fab Fragments; D007457:Iodine Radioisotopes