Genetic environment of acquired bla(ACC-1) beta-lactamase gene in Enterobacteriaceae isolates.
We studied the genetic organization of bla(ACC-1) in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments.
Doloy
A
A
Université Paris VI, UPRES EA 2392, UFR de Médecine Pierre et Marie Curie, Paris, France.
Verdet
C
C
Gautier
V
V
Decré
D
D
Ronco
E
E
Hammami
A
A
Philippon
A
A
Arlet
G
G
D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D003428:Cross Infection / Q000382:microbiology*; D004251:DNA Transposable Elements / Q000235:genetics; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D005798:Genes, Bacterial; D020611:Hafnia alvei / Q000235:genetics; D006801:Humans; D032023:Integrons / Q000235:genetics; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
D004251:DNA Transposable Elements; D001618:beta-Lactamases