title: [Synthesis and characterizations of poly (ethylene glycol)-block-poly (glutamate)].
abstract: Amine-terminated poly (ethylene glycol) (PEG) was prepared by two steps. Firstly, potassium naphthalene was added to a solution of methoxypolyethylene glycol 5,000 in benzene until the solution maintains green in half of an hour, then excess tosylchloride was introduced; secondly, the conversion of the tosylate into an amine was carried out by Gabriel synthesis. The block copolymer poly (ethylene glycol)-co-poly (gamma-benzyl L-glutamate ) could be obtained by ring-opening polymerization of gamma-benzyl-L-glutamate N-carboxy anhydride with amine-terminated PEG as macroinitiator. And the benzyl group could be removed by sodium hydroxide. The product structure was characterized by IR, 1HNMR, GPC. The cisplatin-loaded micelle was observed by transmission electron microscope (TEM). And the block copolymer is expected to be useful as functional materials including carrier systems in drug controlled delivery applications.
authors.affiliation: Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu 610041, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Du
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Lifang
authors.initials: L
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Sun
authors.forename: Chengdong
authors.initials: C
authors.lastname: Xiong
authors.forename: Yuxing
authors.initials: Y
authors.lastname: Peng
mesh_terms: D004337:Drug Carriers; D011092:Polyethylene Glycols / Q000138:chemical synthesis; D011099:Polyglutamic Acid; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D011108:Polymers; D011099:Polyglutamic Acid; D011092:Polyethylene Glycols