The role of nitric oxide.
When studying the impact of endothelins (ETs) on physiology and pathophysiology, this needs to be done in the context of nitric oxide (NO) synthesis and action, since these two are closely intertwined in their action. Here, we will review the work demonstrating the crosstalk between endothelin-1 (ET-1) and NO, and the recent developments regarding the role of these two mediators in inflammatory processes. Moreover, we will discuss the role of NO in pro-inflammatory diseases and the potential mechanisms of the anti-inflammatory activity of ET receptor antagonism.
Kolb-Bachofen
V
V
Department of Medicine, Research Group Immunobiology, Heinrich-Heine-University, Düsseldorf, Germany. bachofen@uni-duesseldorf.de
Kuhn
A
A
Suschek
C V
CV
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase