title: Central and gonadal hypogonadism in X-linked lissencephaly.
abstract: OBJECTIVE
  To directly test gonadal function in a patient with X-linked lissencephaly with ambiguous genitalia (XLAG) in light of lack of previous functional data.
  
  
  RESULTS
  We studied an infant who failed to increase testosterone levels in response to hCG stimulation.
  
  
  CONCLUSIONS
  In XLAG, the gonads are not only structurally dysgenetic but also functionally abnormal.
authors.affiliation: Pediatric Endocrinology, Children's Memorial Hospital, Northwestern University, Chicago, IL, USA. ihalac@childrensmemorial.org
authors.forename: Isil
authors.initials: I
authors.lastname: Halac
authors.forename: Reema
authors.initials: R
authors.lastname: Habiby
authors.forename: John
authors.initials: J
authors.lastname: Curran
authors.forename: Donald
authors.initials: D
authors.lastname: Zimmerman
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D040181:Genetic Diseases, X-Linked / Q000175:diagnosis* / Q000235:genetics; D005837:Genitalia, Male / Q000002:abnormalities* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013739:Testosterone / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; D013739:Testosterone