title: Nodule management protocol of the NELSON randomised lung cancer screening trial.
abstract: In December 2003, the Dutch-Belgian NELSON trial, a Dutch acronym for "Nederlands-Leuvens Longkanker Screenings ONderzoek", has been launched. Primary objective of the NELSON trial is to investigate whether screening for lung cancer by 16-detector multi-slice CT with 16 mm x 0.75 mm collimation and 15 mm table feed per rotation (pitch=1.5) in year 1, 2 and 4 will lead to a decrease in lung cancer mortality in high risk subjects of at least 25% compared to a control group which receives no screening. In this paper, the screening regimen and the classification and management of the screen-detected nodules at baseline and incidence screening is presented. This is the first large lung cancer screening trial in which the nodule management protocol is based on volumetric nodule assessment and the presence or absence of growth. Furthermore, the quality assurance measures and the NELSON management system (NMS) are presented.
authors.affiliation: Department of Radiology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
authors.forename: Dong Ming
authors.initials: DM
authors.lastname: Xu
authors.forename: Hester
authors.initials: H
authors.lastname: Gietema
authors.forename: Harry
authors.initials: H
authors.lastname: de Koning
authors.forename: René
authors.initials: R
authors.lastname: Vernhout
authors.forename: Kristiaan
authors.initials: K
authors.lastname: Nackaerts
authors.forename: Mathias
authors.initials: M
authors.lastname: Prokop
authors.forename: Carla
authors.initials: C
authors.lastname: Weenink
authors.forename: Jan-Willem
authors.initials: JW
authors.lastname: Lammers
authors.forename: Harry
authors.initials: H
authors.lastname: Groen
authors.forename: Matthijs
authors.initials: M
authors.lastname: Oudkerk
authors.forename: Rob
authors.initials: R
authors.lastname: van Klaveren
mesh_terms: D002985:Clinical Protocols; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008403:Mass Screening; D009367:Neoplasm Staging; D011786:Quality Control; D011857:Radiographic Image Interpretation, Computer-Assisted; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000295:instrumentation