title: CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly.
abstract: BACKGROUND
  The pathogenesis of increased blood pressure (BP) in acromegaly is unclear, and the role of IGF-I levels and the renin-angiotensin-aldosterone system (RAAS) in this disease remains controversial.
  
  
  OBJECTIVE
  The aim of this study was to investigate the role of gene polymorphisms of the RAAS and involved in sodium handling on BP in acromegaly.
  
  
  METHODS
  We conducted a multicentric retrospective study that included 100 consecutive patients with acromegaly referred during the period 2000-2003.
  
  
  METHODS
  All patients were genotyped for ACE I/D, AGT M235T, CYP11B2 -344T/C, B2R -58T/C, and alpha-adducin G460W polymorphisms.
  
  
  METHODS
  We assessed the prevalence of hypertension and BP according to the genotype.
  
  
  RESULTS
  Patients with the CYP11B2 -344CC genotype displayed a significant increase in the risk of hypertension compared with patients with CT/TT genotypes (odds ratio = 4.0; 95% confidence interval = 1.4-11.6; P = 0.01). Consistently, a significant proportion of patients with the CYP11B2 -344CC genotypes were under antihypertensive treatment (73.1%) compared with patients with the TT/TC genotypes (38.2%; P = 0.003). Patients with the -344CC genotype displayed a significant increase in systolic BP (10.2 +/- 4.3 mm Hg; P = 0.02) but not a significant increase in diastolic BP (2.6 +/- 2.6 mm Hg; P = 0.32) compared with patients with the CT/TT genotype.
  
  
  CONCLUSIONS
  We have shown an association of the -344T/C CYP11B2 gene polymorphism with BP in patients affected by acromegaly. These findings suggest that the RAAS is implicated in the pathogenesis of hypertension in acromegaly.
authors.affiliation: Division of Internal Medicine, Hypertension Unit, Ospedale San Vito, Strada San Vito 34, 10133 Torino, Italy. paolo.mulatero@libero.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Mulatero
authors.forename: Franco
authors.initials: F
authors.lastname: Veglio
authors.forename: Pietro
authors.initials: P
authors.lastname: Maffei
authors.forename: Marta
authors.initials: M
authors.lastname: Bondanelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Bovio
authors.forename: Fulvia
authors.initials: F
authors.lastname: Daffara
authors.forename: Giannina
authors.initials: G
authors.lastname: Leotta
authors.forename: Alberto
authors.initials: A
authors.lastname: Angeli
authors.forename: Chiara
authors.initials: C
authors.lastname: Calvo
authors.forename: Chiara
authors.initials: C
authors.lastname: Martini
authors.forename: Ettore C
authors.initials: EC
authors.lastname: degli Uberti
authors.forename: Massimo
authors.initials: M
authors.lastname: Terzolo
mesh_terms: D000172:Acromegaly / Q000235:genetics* / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D019405:Cytochrome P-450 CYP11B2