title: The influence of formulation on the dissolution profile of diclofenac sodium tablets.
abstract: In attempts to design delayed-release tablets of diclofenac sodium, seven experimental batches were produced. The influence of super-disintegrant croscarmellose sodium (CCS), the granulation process, and the thickness of Eudragit L 100 coating film were evaluated. The values of dissolution efficiency and the similarity factor were used to compare the dissolution profiles of each experimental batch and the reference Voltaren. Both methods appear to be applicable and useful in comparing dissolution profiles. Based on such values four batches were considered similar when contrasted with the reference. The results suggest an optimal relationship between the amount of CCS and the thickness of the coating film, which provides appropriate dissolution rate of diclofenac sodium from the dosage forms.
authors.affiliation: Fundação Ezequiel Dias. Rua Conde Pereira Carneiro 80, CEP 30610-150, Belo Horizonte, MG, Brazil. whocely@ufl.edu
authors.forename: W V
authors.initials: WV
authors.lastname: De Castro
authors.forename: M A S
authors.initials: MA
authors.lastname: Pires
authors.forename: M A
authors.initials: MA
authors.lastname: Oliveira
authors.forename: C D
authors.initials: CD
authors.lastname: Vianna-Soares
authors.forename: E A
authors.initials: EA
authors.lastname: Nunan
authors.forename: G A
authors.initials: GA
authors.lastname: Pianetti
authors.forename: L M
authors.initials: LM
authors.lastname: Moreira-Campos
authors.forename: W V
authors.initials: WV
authors.lastname: De Castro
authors.forename: S U
authors.initials: SU
authors.lastname: Mertens-Talcott
authors.forename: H
authors.initials: H
authors.lastname: Derendorf
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D012995:Solubility; D013607:Tablets
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D005079:Excipients; D011109:Polymethacrylic Acids; D013607:Tablets; D004008:Diclofenac; C038300:methylmethacrylate-methacrylic acid copolymer; D002266:Carboxymethylcellulose Sodium