title: The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.
abstract: Multidrug and toxic compound extrusion (MATE) proteins, comprising the most recently designated family of multidrug transporter proteins, are widely distributed in all kingdoms of living organisms, although their function is far from understood. The bacterial MATE-type transporters that have been characterized function as exporters of cationic drugs, such as norfloxacin and ethidium, through H(+) or Na(+) exchange. Plant MATE-type transporters are involved in the detoxification of secondary metabolites, including alkaloids. Mammalian MATE-type transporters are responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H(+). Thus, we propose that members of the MATE family are organic cation exporters that excrete metabolic or xenobiotic organic cations from the body.
authors.affiliation: Laboratory of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Omote
authors.forename: Miki
authors.initials: M
authors.lastname: Hiasa
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Masato
authors.initials: M
authors.lastname: Otsuka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Moriyama
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D017920:Antiporters / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D001711:Biotransformation; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D027701:Organic Cation Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D013256:Steroids / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: C434471:ALF5 protein, Arabidopsis; D018435:ATP Binding Cassette Transporter, Subfamily B; D017920:Antiporters; D029681:Arabidopsis Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C449804:DTX1 protein, Arabidopsis; C514424:MATE1 protein, mouse; C114619:NorM protein, bacteria; D027701:Organic Cation Transport Proteins; D004364:Pharmaceutical Preparations; D029701:Saccharomyces cerevisiae Proteins; D013256:Steroids; D014157:Transcription Factors; D015262:Xenobiotics; C436245:tt12 protein, Arabidopsis