title: Uterine fibroids: a review of health-related quality of life assessment.
abstract: OBJECTIVE
  To summarize the literature describing the impact of uterine fibroids on health-related quality of life (HRQOL), the measures used to assess HRQOL, and related areas for future research.
  
  
  METHODS
  A search of three electronic databases (MEDLINE, Embase, and Current Contents) was performed, and 40 papers were identified referencing leiomyoma or uterine fibroids and (health-related) quality of life (HRQOL). Studies including women with benign gynecological conditions other than uterine fibroids were also reviewed.
  
  
  RESULTS
  The EQ-5D, SF-36, and related generic measures are used to assess HRQOL in women with diverse gynecological conditions, including uterine fibroids. The UFS-QOL, a condition- specific measure, provides scores on symptom severity and six HRQOL dimensions. All instruments consistently demonstrate that HRQOL is considerably impaired in women with symptomatic uterine fibroids and that appropriate treatment can lead to improved QOL.
  
  
  CONCLUSIONS
  The published data on HRQOL associated with uterine fibroids report significantly lower HRQOL scores for women with fibroids than for women without this disorder. Additional research is needed to confirm these findings and provide greater detail describing the specific domains most affected by uterine fibroids. These advances are necessary to effectively compare new treatment modalities vs. standard invasive therapies, such as hysterectomy.
authors.affiliation: RTI Health Solutions, Research Triangle Park, NC, 27709-2194, USA. vwilliams@rti.org
authors.forename: Valerie S L
authors.initials: VS
authors.lastname: Williams
authors.forename: Georgina
authors.initials: G
authors.lastname: Jones
authors.forename: Josephine
authors.initials: J
authors.lastname: Mauskopf
authors.forename: James
authors.initials: J
authors.lastname: Spalding
authors.forename: Janeen
authors.initials: J
authors.lastname: DuChane
mesh_terms: D000223:Adaptation, Psychological; D001294:Attitude to Health; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000523:psychology* / Q000628:therapy; D011788:Quality of Life; D012720:Severity of Illness Index; D014594:Uterine Neoplasms / Q000523:psychology* / Q000628:therapy; D016387:Women's Health