The 1H NMR method for the determination of the absolute configuration of 1,2,3-prim,sec,sec-triols.
The absolute configuration of 1,2,3-prim,sec,sec-triols can be assigned by comparison of the 1H NMR spectra of the tris-(R)- and the tris-(S)-MPA ester derivatives. An experimental demonstration of this correlation with 24 triols of known absolute configuration and a protocol using two parameters-Deltadelta(RS)(H3) and the difference between Deltadelta RS (H2) and Deltadelta RS (H3) = absolute value (Delta(Deltadelta RS))-for its application to the determination of the absolute configuration of other triols are presented.
Lallana
Enrique
E
Departamento de Química Organica and Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Freire
Félix
F
Seco
José Manuel
JM
Quiñoa
Emilio
E
Riguera
Ricardo
R
D000438:Alcohols / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D011522:Protons
D000438:Alcohols; D011522:Protons