[Effect of the concomitant administration of indomethacin or ibuprofen on amikacin pharmacokinetics in premature newborns].
OBJECTIVE
To evaluate whether the concomitant administration of ibuprofen or indomethacin plus amikacin may alter the latter drug s pharmacokinetic parameters, and hence amikacin plasma levels.


METHODS
Retrospective cohort study performed by reviewing the medical records of premature children with persistent ductus arteriosus receiving amikacin and ibuprofen, or amikacin and indomethacin. They were divided up into three groups: group 1: treatment with amikacin went before indomethacin or ibuprofen; group 2: simultaneously treated with amikacin and indomethacin; group 3: simultaneously treated with amikacin and ibuprofen. Pharmacokinetic parameters, distribution volume, and amikacin clearance were measured using the PKS program (a non-linear regression method). Half life was determined from previous parameters.


RESULTS
Twenty-eight patients were included. No statistically significant differences were found among pharmacokinetic parameters corresponding to each study group.


CONCLUSIONS
Further studies are needed with a greater number of patients and currently recommended doses to assess the influence of indomethacin and ibuprofen in the pharmacokinetics of amikacin in premature children with persistent ductus arteriosus.
Cuesta Grueso
C
C
Servicios de Farmacia, Hospital Universitario La Fe, Avda. Campanar 21, 46009 Valencia, Spain. grueso_cri@gva.es
Gimeno Navarro
A
A
Marqués Miñana
M R
MR
Peris Ribera
J E
JE
Morcillo Sopena
F
F
Poveda Andrés
J L
JL
D000583:Amikacin / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D015331:Cohort Studies; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents; D016861:Cyclooxygenase Inhibitors; D000583:Amikacin; D007052:Ibuprofen; D007213:Indomethacin