[Evaluation of the efficiency of activity of the liposomal form of isoniazid against different types of mycobacteria in vitro].
M. avium and three M. tuberculosis strains were used as an example to study the bacteriostatic activity of the liposomal form of isoniazid in the liquid nutrient medium by serial dilutions. Unlike isoniazid in solution, its liposomal form was found to suppress the multi plication of all study mycobacterial samples and diminishes their viability, but at different concentrations. The liposomes that did not contain the drug exerted an inhibitory effect only on the M. tuberculosis strains H37Rv and Erdman. It is suggested that the change in isoniazid sensitivity results from the effect of liposomal phospholipids on some mycobacterial enzymes. Electron microscopy indicated that the liposomal form of isoniazid is able to penetrate into the alveolar macrophageal cytoplasm of guinea pigs just 30 min after incubation.
Golyshevskaia
V I
VI
Selishcheva
A A
AA
Martynova
L P
LP
Lepekha
L N
LN
Kalashnikova
T M
TM
Kornilova
Z Kh
ZKh
Erokhin
V V
VV
Rozenberg
O A
OA
D000995:Antitubercular Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D007538:Isoniazid / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D008081:Liposomes / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology
D000995:Antitubercular Agents; D008081:Liposomes; D007538:Isoniazid