[Prognostic value of the expression of thyreoglobulin and oncomarkers (p53, EGFR, ret-oncogene) in different types of papillary carcinoma of the thyroid: clinicomorphological and immunohistochemical studies].
The surgical material obtained from 57 patients was immunohistochemically studied. Immunohistochemistry with quantitative and semiquantitative analyses of the results of test was used to define the expression of oncomarkers p53, EGRF, ret-oncogene, and thyreoglobulin. The expression of thyreoglobulin, EGRF, and ret-oncogene reflects the malignant potential of papillary carcinoma of the thyroid and and may be recommended as a predictive marker. The low expression of thyreoglobulin and the high expression of p53 and ret-oncogene are markers of a poor prognosis and tumor recurrence. EGFR expression is not of predictive value. MB3 proposed by the authors may be recommended for the determination of the malignant potential of papillary carcinoma of the thyroid.
Kogan
E A
EA
Rozhkova
E B
EB
Seredin
V P
VP
Paltsev
M A
MA
D014408:Biomarkers, Tumor / Q000032:analysis*; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011379:Prognosis; D051096:Proto-Oncogene Proteins c-ret / Q000032:analysis; D013954:Thyroglobulin / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53; D013954:Thyroglobulin; D066246:ErbB Receptors; D051096:Proto-Oncogene Proteins c-ret