[Neuroprotective effect of antipsychotic drugs (neuroleptics) in global brain ischemia].
Most of typical and atypical neuroleptics belonging to various chemical groups produce a significant, dose-dependent increase in the brain tolerance to global ischemia. This activity of neuroleptics is related to their structure and exhibits no correlation with their antipsychotic properties. Therefore, the ability to increase the brain tolerance to global ischemia is an independent property of neuroleptics. The neuroprotective effect is also not correlated with their affinity to serotonin 5-HT2A and dopamine D2 receptors, but is closely related to the development of deep hypothermia. Thermoneutral conditions prevent both effects. Tolerant strategy plays the main role in the development of the neuroprotective effect of neuroleptics.
Kulinskiĭ
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Gavrilov
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D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy*; D065127:Dopamine D2 Receptor Antagonists; D005260:Female; D007035:Hypothermia / Q000139:chemically induced; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D058830:Serotonin 5-HT2 Receptor Antagonists
D014150:Antipsychotic Agents; D065127:Dopamine D2 Receptor Antagonists; D018696:Neuroprotective Agents; D058830:Serotonin 5-HT2 Receptor Antagonists