title: Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.
abstract: Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.
authors.affiliation: Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85723, USA.
authors.forename: Lisa F
authors.initials: LF
authors.lastname: Shubitz
authors.forename: John N
authors.initials: JN
authors.lastname: Galgiani
authors.forename: Zong-Qiang
authors.initials: ZQ
authors.lastname: Tian
authors.forename: Ziyang
authors.initials: Z
authors.lastname: Zhong
authors.forename: Pieter
authors.initials: P
authors.lastname: Timmermans
authors.forename: Leonard
authors.initials: L
authors.lastname: Katz
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003045:Coccidioides / Q000187:drug effects*; D003047:Coccidioidomycosis / Q000188:drug therapy* / Q000401:mortality; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D011714:Pyrans; C014964:ambruticin