title: Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study.
abstract: OBJECTIVE
  Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits.
  
  
  METHODS
  Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and the zygomatic bones were macro- and microscopically analyzed. Student's, Fisher's, chi-squared and McNemar's tests were used for statistical analysis.
  
  
  RESULTS
  Both the castor oil polyurethane and the autograft adapted well to the defect, with no need for fixation. Fibrous connective tissue encapsulated the polyurethane, but no inflammation or giant cell reaction was observed. Acidophilic and basophilic areas were observed inside the micropores of the polyurethane, suggesting cell nuclei. After 90 days, bone repair with a lamellar pattern of organization was observed in the control group.
  
  
  CONCLUSIONS
  The castor oil polyurethane was biocompatible and did not cause inflammation. It may be considered an alternative to fill bone defects.
authors.affiliation: Multinational Graduate Program in Health Sciences, University Hospital, Federal University of Mato Grosso do Sul (UFMS), Rua Vista Alegre 505, 79041-330 Campo Grande, MS, Brazil. mendonca@nin.ufms.br
authors.forename: José Carlos Garcia de
authors.initials: JC
authors.lastname: Mendonça
authors.forename: Rafael
authors.initials: R
authors.lastname: De Rossi
authors.forename: Celso Massaschi
authors.initials: CM
authors.lastname: Inouye
authors.forename: Diego Rodrigo Paulillo
authors.initials: DR
authors.lastname: Bazan
authors.forename: João Carlos Castro
authors.initials: JC
authors.lastname: Monteiro
authors.forename: Juliana Pedroso de
authors.initials: JP
authors.lastname: Mendonça
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001835:Body Weight; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods / Q000473:pathology*; D002368:Castor Oil / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D008422:Materials Testing; D011140:Polyurethanes / Q000627:therapeutic use*; D011817:Rabbits; D011897:Random Allocation; D013977:Tibia / Q000601:surgery; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D015050:Zygoma / Q000002:abnormalities / Q000601:surgery* / Q000648:ultrastructure
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011140:Polyurethanes; D002368:Castor Oil