title: [Products toxic to reproduction used in the occupational environment: Definition, risk assessment, classification].
abstract: European regulations (transcribed into French law) aimed at protecting employees from chemicals toxic to reproduction enable classification and labelling of such substances, if they are liable to cause an alteration of male or female reproductive functions or capacity, or to induce non-hereditary harmful effects on their offspring. Three categories can be used to classify these substances in two areas, namely their impairment of fertility and their effects on development. This classification is rarely based on epidemiological study results, but most often on those of experimental toxicological studies conducted by substance manufacturers. These reproduction toxicological studies are only compulsory above a certain tonnage placed on the market. The high level of this tonnage means that these tests are effectively only conducted on rare occasions. It is reckoned that there is no reproduction experimental data for over 95% of substances newly placed on the market. These products therefore appear to be reproduction non-toxic only because they have not been tested. This is a major fault in the current labelling system, which does not allow non-toxic products to be differentiated from non-tested products. The future EU regulatory framework for Registration, Evaluation and Authorisation of CHemicals (REACH) will only slightly enhance information in this area. It can be estimated that over 80% of chemical products will not be exhaustively tested for reproduction and nearly 75% will not be tested to any degree.
authors.affiliation: Département études et assistance médicale, INRS, centre de Paris, 30, rue Olivier-Noyer, 75014 Paris, France. lafon@inrs.fr
authors.forename: D
authors.initials: D
authors.lastname: Lafon
mesh_terms: D005060:Europe; D005260:Female; D015386:Hazardous Substances / Q000145:classification* / Q000633:toxicity*; D006801:Humans; D007246:Infertility / Q000139:chemically induced / Q000453:epidemiology; D008297:Male; D016273:Occupational Exposure / Q000145:classification / Q000331:legislation & jurisprudence; D011247:Pregnancy; D012098:Reproduction
chemical_list: D015386:Hazardous Substances