title: Anaplastic large-cell non-Hodgkin's lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer--a case report.
abstract: Primary, as well as secondary, lymphomas of the breast are rare diseases and might, in some cases, be misdiagnosed as breast cancer on routine hematoxylin/eosin stainings. We report a case of an anaplastic large cell lymphoma in a 72-year-old woman with a history of breast cancer treated with breast-ablative surgery and a subsequent silicon implant 32 years ago. Clinically, she presented with an ulceration of the skin, which had developed within a few months. On conventional histology, the tumor cells were mimicking poorly differentiated invasive ductal carcinoma with a prominent leukocytic infiltrate. The immunoprofile of the tumor showed negativity for cytokeratins and led to the diagnosis of a CD30-positive anaplastic large cell lymphoma.
authors.affiliation: Institute of Pathology, Charité Universitätsmedizin Berlin, Schumannstr. 20/21, 10117 Berlin, Germany.
authors.forename: Florian Rudolf
authors.initials: FR
authors.lastname: Fritzsche
authors.forename: Stefan
authors.initials: S
authors.lastname: Pahl
authors.forename: Iver
authors.initials: I
authors.lastname: Petersen
authors.forename: Mick
authors.initials: M
authors.lastname: Burkhardt
authors.forename: Anja
authors.initials: A
authors.lastname: Dankof
authors.forename: Manfred
authors.initials: M
authors.lastname: Dietel
authors.forename: Glen
authors.initials: G
authors.lastname: Kristiansen
mesh_terms: D000368:Aged; D018427:Breast Implants; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000473:pathology* / Q000628:therapy
chemical_list: D017730:Ki-1 Antigen