title: Native valve Aspergillus endocarditis in two patients with aplastic anaemia.
abstract: Native valve fungal endocarditis is an uncommon disease with a high mortality rate. We present the clinical features, histological findings and outcome of 2 patients with native valve Aspergillus endocarditis. Both patients had aplastic anaemia as a predisposing disease. The diagnosis was made by Duke's criteria in 1 case and by histology in the other. Surgery was precluded owing to profound thrombocytopenia. Both patients had fatal outcome despite administration of liposomal amphotericin beta.
authors.affiliation: First Department of Propedeutic Internal Medicine, Laiko General Hospital, Athens University, Athens, Greece.
authors.forename: G L
authors.initials: GL
authors.lastname: Petrikkos
authors.forename: A
authors.initials: A
authors.lastname: Skiada
authors.forename: G
authors.initials: G
authors.lastname: Samonis
authors.forename: D
authors.initials: D
authors.lastname: Mavroudis
authors.forename: G L
authors.initials: GL
authors.lastname: Daikos
mesh_terms: D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000150:complications*; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D000077336:Caspofungin; D054714:Echinocandins; D004696:Endocarditis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D055666:Lipopeptides; D008297:Male; D010456:Peptides, Cyclic / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B; D000077336:Caspofungin