title: Novel approach to control sulfamethazine misuse in food-producing animals by hair analysis.
abstract: The presence of sulfamethazine residues in pig and calf hair was compared with the residual levels encountered in the corresponding edible tissues (liver and muscle) as a consequence of drug administration. Sulfamethazine up to 84.7 mg kg-1 was found in calf hair samples after a pharmacological treatment, with a significant effect of hair pigmentation. High concentrations of the parent drug were detected in calf hair for 4 weeks after administration, when sulfamethazine residues were no longer detectable in the corresponding edible tissues. In a similar way, pig hair also accumulated sulfamethazine residues up to 40.5 mg kg-1, which was more than the amount detected in the corresponding muscle and liver samples at slaughter. Hair analysis seems a suitable tool to improve the efficacy of regulatory controls, and thus the safety of the food chain and to discourage the improper use of sulfamethazine in animal farming.
authors.affiliation: IRTA-CTC, Food Chemistry Unit, Granja Camps i Armet s/n, E-17121 Monells, Girona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gratacós-Cubarsí
authors.forename: M
authors.initials: M
authors.lastname: Castellari
authors.forename: A
authors.initials: A
authors.lastname: Valero
authors.forename: I
authors.initials: I
authors.lastname: Diaz
authors.forename: J A
authors.initials: JA
authors.lastname: García-Regueiro
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000032:analysis*; D002417:Cattle; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004350:Drug Residues / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis; D006197:Hair / Q000737:chemistry*; D008099:Liver / Q000737:chemistry; D008460:Meat / Q000032:analysis*; D018482:Muscle, Skeletal / Q000737:chemistry; D015813:Substance Abuse Detection / Q000379:methods / Q000662:veterinary*; D013418:Sulfamethazine / Q000032:analysis*; D034421:Sus scrofa
chemical_list: D000890:Anti-Infective Agents; D013418:Sulfamethazine