title: Characterization of estrogen receptors alpha and beta in uterine leiomyoma cells.
abstract: OBJECTIVE
  Cellular and subcellular localization of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) in uterine leiomyomas.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University of La Laguna (ULL) and Canary University Hospital (HUC).
  
  
  METHODS
  Premenopausal and postmenopausal women with uterine leiomyomas.
  
  
  METHODS
  Hysterectomy and myomectomy.
  
  
  RESULTS
  Estrogen receptor alpha was only present in smooth muscle cells with variation in the subcellular location in different leiomyomas. Estrogen receptor beta was widely distributed in smooth muscle, endothelial, and connective tissue cells with nuclear location in all cases studied; variations were only found in the muscle cells for this receptor.
  
  
  CONCLUSIONS
  Estrogens operate in leiomyoma smooth muscle cells through different receptors, alpha and beta. However they only act through the ERbeta in endothelial and connective cells.
authors.affiliation: Departamento de Anatomía, Anatomía Patológica e Histología, Universidad de La Laguna, Tenerife, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Valladares
authors.forename: Ignacio
authors.initials: I
authors.lastname: Frías
authors.forename: Delia
authors.initials: D
authors.lastname: Báez
authors.forename: Candelaria
authors.initials: C
authors.lastname: García
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: López
authors.forename: James D
authors.initials: JD
authors.lastname: Fraser
authors.forename: Yurena
authors.initials: Y
authors.lastname: Rodríguez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Reyes
authors.forename: Lucio
authors.initials: L
authors.lastname: Díaz-Flores
authors.forename: Aixa R
authors.initials: AR
authors.lastname: Bello
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism*; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D012189:Retrospective Studies; D014018:Tissue Distribution; D014594:Uterine Neoplasms / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D009363:Neoplasm Proteins