title: Impaired blood rheology in critically ill patients in an intensive care unit.
abstract: Critically ill patients are at increased risk of thromboembolic complications. Japanese patients admitted to the intensive care unit of Gunma University Hospital were divided into critically ill (high score) and moderately ill (low score) groups according to mean Acute Physiology and Chronic Health Evaluation (APACHE) II score. White blood cell count, potassium, creatinine, immunoglobulin G and blood passage time, measured using the microchannel method, were significantly higher and the platelet aggregation score and platelet count were significantly lower in the high-score group than in the low-score group, but other haemorheological parameters did not differ significantly between the two groups. White blood cell count, potassium, creatinine, APACHE II score and levels of immunoglobulins G, A and M were positively correlated with blood passage time in all patients. Critically ill patients had impaired blood rheology, which could result from increased white blood cell count, potassium, creatinine and immunoglobulins and may be associated with the pathophysiology of the thromboembolic process.
authors.affiliation: Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Muranaka
authors.forename: F
authors.initials: F
authors.lastname: Kunimoto
authors.forename: J
authors.initials: J
authors.lastname: Takita
authors.forename: H
authors.initials: H
authors.lastname: Sumino
authors.forename: M
authors.initials: M
authors.lastname: Nara
authors.forename: H
authors.initials: H
authors.lastname: Kuwano
authors.forename: M
authors.initials: M
authors.lastname: Murakami
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D001809:Blood Viscosity / Q000502:physiology*; D016638:Critical Illness; D005260:Female; D006403:Hematologic Tests; D018056:Hemorheology; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D013923:Thromboembolism / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology