title: Vulvar cancer metastatic to the breast.
abstract: BACKGROUND
  Vulvar cancer rarely sends metastases to distant sites.
  
  
  METHODS
  A 49-year-old female presented with a vulvar mass. The histologic examination revealed an infiltrating lesion with free surgical margins and no evidence of lymph node involvement. Four months following surgery, due to a bloody breast discharge and a palpable breast lump an excisional biopsy was performed. The histological evaluation revealed morphological features suggestive of metastatic squamous cell carcinoma. The morphological, immunohistochemical and in situ hybridization findings were consistent with a breast metastatic nodule of squamous cell carcinoma arising from the primary vulvar cancer.
  
  
  CONCLUSIONS
  We conclude that the specimens are from the same origin therefore making the breast lesion a metastasis from the vulva.
authors.affiliation: Obstetrics and Gynecology Department, Sheba Tel--Hashomer Medical Center and Sackler School of Medicine, Tel-Aviv, Israel. dvicus@gmail.com
authors.forename: D
authors.initials: D
authors.lastname: Vicus
authors.forename: J
authors.initials: J
authors.lastname: Korach
authors.forename: E
authors.initials: E
authors.lastname: Friedman
authors.forename: S
authors.initials: S
authors.lastname: Rizel
authors.forename: G
authors.initials: G
authors.lastname: Ben-Baruch
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery