Acceleration of lipid degradation by sericoside of Terminalia sericea roots in Fully differentiated 3T3-L1 cells.
Sericoside is a traditional herbal saponin from Terminalia sericea (Family Combretaceae). The influence of sericoside on lipolysis was studied in fully differentiated 3T3-L1 cells, and glycerol release into the cytosol and residual triglyceride were measured. The addition of sericoside stimulated glycerol release into the cytosol from deposited triglyceride in a dose- and time-dependent manner. These data suggested that sericoside has a strong lipolytic activity.
Mochizuki
Miyako
M
Department of Health and Nutrition, Faculty of Home Economics, Gifu Women's University, Gifu, Japan.
Hasegawa
Noboru
N
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000008:administration & dosage / Q000494:pharmacology*; D005990:Glycerol / Q000032:analysis; D050356:Lipid Metabolism / Q000187:drug effects*; D008066:Lipolysis / Q000187:drug effects; D051379:Mice; D009765:Obesity / Q000517:prevention & control; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D029766:Terminalia / Q000737:chemistry*; D013997:Time Factors; D014280:Triglycerides / Q000032:analysis
D005960:Glucosides; D014280:Triglycerides; D009828:Oleanolic Acid; D005990:Glycerol; C479759:sericoside