Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer.
Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C(12)-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-kappaB signaling pathway besides their quorum-sensing role, like 3-oxo-C(12)-HSL from Pseudomonas aeruginosa.
Gomi
Kazunori
K
Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-Ku, Sendai 980-8575, Japan. gomi@idac.tohoku.ac.jp
Kikuchi
Toshiaki
T
Tokue
Yutaka
Y
Fujimura
Shigeru
S
Uehara
Akiko
A
Takada
Haruhiko
H
Watanabe
Akira
A
Nukiwa
Toshihiro
T
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D002861:Chromobacterium / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D006714:Homoserine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D016328:NF-kappa B / Q000819:agonists
D016207:Cytokines; C516096:N-dodecanoyl-DL-homoserine lactone; D016328:NF-kappa B; D006714:Homoserine; D015107:4-Butyrolactone