title: Influence of two different types of cardioplegia on hemodilution during and after cardiopulmonary bypass, postoperative chest-drainage bleeding and consumption of donor blood products.
abstract: The aim of this study is to compare the effects of colloidal cardioplegia and blood cardioplegia in patients who underwent cardiac surgical procedures with cardiopulmonary bypass, and to evaluate their influence on hemodilution, bleeding and consumption of donor blood products in a retrospective clinical study. 100 male patients who underwent cardiac surgical procedure were divided into two groups: 50 patients were administered intermittent normotherm or mild hypotherm (34 degrees C) Calafiore blood cardioplegia with potassium chloride 14,9%; 50 patients were administered one initial doses of cold Kirsch - solution followed from intermittent cold colloidal cardioplegia using hydroxyethyl starch (HES 450/0,7). Hemoglobin values after the first dose of cardioplegia were significantly lower in the HES-group than in the Calafiore- group). After the first dose of cardioplegia platelets count was lower in the HES-group than in the Calafiore-group. Hemoglobin and hematocrit values 24h postoperative were lower in the HES-group than in the Calafiore-group. There was no difference in chest-drainage bleeding 12h and 24h postoperative between the groups. The consumption of donor erythrocyte concentrate and fresh frozen plasma was significantly higher in the HES-than in the Calafiore- group. The choice of either colloidal or blood cardioplegia does not influence the postoperative chest-drainage bleeding. The results suggest that high molecular colloidal cardioplegia with HES-solution is associated with higher hemodilution during and after cardiopulmonary bypass and significantly increases the consumption of donor blood products.
authors.affiliation: Heart Center Sarajevo, University of Sarajevo Clinics Center, Bosnia and Herzegovina.
authors.forename: Mirsad
authors.initials: M
authors.lastname: Kacila
authors.forename: Katrin
authors.initials: K
authors.lastname: Schäfer
authors.forename: Esad
authors.initials: E
authors.lastname: Subasić
authors.forename: Nermir
authors.initials: N
authors.lastname: Granov
authors.forename: Edin
authors.initials: E
authors.lastname: Omerbasić
authors.forename: Faida
authors.initials: F
authors.lastname: Kucukalić
authors.forename: Ermina
authors.initials: E
authors.lastname: Selimović-Mujcić
mesh_terms: D016913:Blood Component Transfusion; D002314:Cardioplegic Solutions; D002315:Cardiopulmonary Bypass / Q000379:methods*; D006324:Heart Arrest, Induced / Q000009:adverse effects* / Q000379:methods*; D006400:Hematocrit; D006438:Hemodilution; D006454:Hemoglobins; D006801:Humans; D008297:Male; D019106:Postoperative Hemorrhage / Q000209:etiology*; D012189:Retrospective Studies
chemical_list: D002314:Cardioplegic Solutions; D006454:Hemoglobins