title: Posttranslational modifications of NEMO and its partners in NF-kappaB signaling.
abstract: NEMO, the regulatory subunit of the IkappaB kinase (IKK) complex that controls the activation of the transcription factor NF-kappaB, is required for IKK function in most situations, but its exact mode of action has remained elusive until recently. A series of publications now provides information about how posttranscriptional modifications of NEMO, such as ubiquitination, sumoylation or phosphorylation, regulate its function in the IKK complex. These modifications might also regulate a cytosolic pool of free NEMO that controls the activation of NF-kappaB induced by genotoxic stress. Together with a better identification of the modifications controlling partners of NEMO, a clearer picture of how IKK becomes activated upon cell stimulation is starting to emerge, providing new clues for how the NF-kappaB pathway could be modulated for therapeutic purposes.
authors.affiliation: INSERM U697, Hôpital Saint-Louis, Paris 75010, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Sebban
authors.forename: Shoji
authors.initials: S
authors.lastname: Yamaoka
authors.forename: Gilles
authors.initials: G
authors.lastname: Courtois
mesh_terms: D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: C491731:IKBKG protein, human; D016328:NF-kappa B; D051550:I-kappa B Kinase