title: Acute limb ischemia associated with type B aortic dissection: clinical relevance and therapy.
abstract: BACKGROUND
  The goal of the current study is to characterize the presentation, therapy, and outcomes of acute limb ischemia (ALI) associated with type B aortic dissection (AoD).
  
  
  METHODS
  The prospective/retrospective International Registry for Acute Aortic Dissection (IRAD) database and a single institutional database were queried for all patients with type B AoD from 1996 to 2002. Univariate and multivariate statistics were used to delineate factors associated with morbidity and mortality outcomes.
  
  
  RESULTS
  According to the IRAD data (n = 458), the mean age of patients was 64 years, and 70% were men. The overall mortality was 12%; of these, 6% had ALI. Pulse (3-fold) and neurologic deficits (5-fold) were more common in those with ALI (P < .001). Endovascular, but not surgical therapy, was more commonly performed in patients with ALI compared with those without ALI (31% vs 10%, P = .004). No difference in age, race, gender, or origin of dissection was observed. ALI was associated with acute renal failure (odds ratio [OR] = 2.7; 95% confidence interval [CI] 1.1-7.1; P = .048) and acute mesenteric ischemia/infarction (OR = 6.9; 95% CI 2.5-20; P < .001). Adjusting for patient characteristics, ALI was associated with death (3.5; 95% CI 1.1-10; P = .02). The single institution analysis revealed similar patient demographics and mortality in 93 AoD patients, of whom 28 had ALI. Aortic fenestration or aorto-iliac stenting was the primary therapy in 93%; surgical bypass was used in 7%. Limb salvage was 93% in those with ALI at a mean of 18 months follow-up. The number of organ systems with malperfusion was 2-fold higher at aortography than suspected preprocedure (P = .002). By stepwise regression modeling, mortality was greater in those not taking a beta-blocker (OR = 19; 95% CI 3.1-111; P = .001).
  
  
  CONCLUSIONS
  ALI secondary to AoD is predictive of death and visceral ischemia. Endovascular therapy confers excellent limb salvage and allows diagnosis of unsuspected visceral ischemia.
authors.affiliation: Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich, USA. henke@umich.edu
authors.forename: Peter K
authors.initials: PK
authors.lastname: Henke
authors.forename: David M
authors.initials: DM
authors.lastname: Williams
authors.forename: Gilbert R
authors.initials: GR
authors.lastname: Upchurch
authors.forename: Mary
authors.initials: M
authors.lastname: Proctor
authors.forename: Jeanna V
authors.initials: JV
authors.lastname: Cooper
authors.forename: Jianming
authors.initials: J
authors.lastname: Fang
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Nienaber
authors.forename: Eric M
authors.initials: EM
authors.lastname: Isselbacher
authors.forename: Rosella
authors.initials: R
authors.lastname: Fattori
authors.forename: Nara
authors.initials: N
authors.lastname: Dasika
authors.forename: Joesph
authors.initials: J
authors.lastname: Gemmete
authors.forename: James C
authors.initials: JC
authors.lastname: Stanley
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Wakefield
authors.forename: Kim A
authors.initials: KA
authors.lastname: Eagle
mesh_terms: D000208:Acute Disease; D000368:Aged; D000784:Aortic Dissection / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D001013:Aorta, Thoracic; D017545:Aortic Aneurysm, Thoracic / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D015897:Comorbidity; D005121:Extremities / Q000098:blood supply; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000401:mortality* / Q000601:surgery*; D023821:Limb Salvage / Q000401:mortality / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012042:Registries; D016019:Survival Analysis; D016896:Treatment Outcome