Successful treatment of lichen amyloidosis with combined bath PUVA photochemotherapy and oral acitretin.
Lichen amyloidosis (LA) is a chronic, pruritic skin disorder characterized by brownish-grey papules on extensor surfaces of legs and rarely on the trunk. Thioflavin T-positive amyloid deposits are found in the papillary dermis of affected skin, which is the only organ involved. A variety of therapeutic regimens for lichen amyloidosis have been described; however, in many cases with only limited effect. We report on two patients with lichen amyloidosis with typical clinical symptoms not responding to local treatment. A combined regimen with bath psoralen ultraviolet A (PUVA) and oral acitretin was initiated, resulting in nearly complete resolution of the papules and impressive relief from the severe pruritus. The beneficial response has persisted for 8 months. The suggested combined therapy with bath PUVA photochemotherapy and oral acitretin represents an efficacious and practical treatment modality for lichen amyloidosis with long-lasting effects.
Grimmer
J
J
Department of Dermatology and Allergic Diseases, University of Ulm, Germany.
Weiss
T
T
Weber
L
L
Meixner
D
D
Scharffetter-Kochanek
K
K
D017255:Acitretin / Q000627:therapeutic use*; D000368:Aged; D000686:Amyloidosis / Q000628:therapy*; D001494:Baths; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D007868:Leg Dermatoses / Q000628:therapy; D017512:Lichenoid Eruptions / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D016896:Treatment Outcome
D007641:Keratolytic Agents; D017255:Acitretin