title: Pancreatic acinar cell carcinoma extending into the common bile and main pancreatic ducts.
abstract: Acinar cell carcinoma (ACC) of the pancreas is relatively rare, accounting for only approximately 1% of all exocrine pancreatic tumors. A 69-year-old man was found to have a mass lesion measuring approximately 4 cm in diameter in the pancreatic head on ultrasound, abdominal dynamic CT, and percutaneous transhepatic cholangiography. Magnetic resonance cholangiopancreatography showed defect of the lower common bile duct (CBD) due to obstruction by the tumor cast. Histopathologically, the pancreatic head tumor invaded the main pancreatic duct (MPD) and CBD with extension into the CBD in a form of tumor cast. The tumor cells consisted of a solid proliferation with abundant eosinophilic cytoplasm and round nuclei in an acinar and trabecular fashion. A 55-year-old man with upper abdominal pain and nausea, had a cystic lesion approximately 3 cm in size in the pancreatic tail on CT. Histopathologically, the tumor was encapsulated by fibrous capsule and had extensive central necrosis with solid areas in the tumor periphery, and invaded with extension into the MPD in a form of tumor cast. The tumor cells resembled acinar cells in solid growths. Two resected cases of ACC with unusual tumor extension into the CBD and the MPD, respectively, are reported.
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan. rin@med.kurume-u.ac.jp
authors.forename: Rin
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Okabe
authors.forename: Atsuo
authors.initials: A
authors.lastname: Jimi
authors.forename: Koji
authors.initials: K
authors.lastname: Shiota
authors.forename: Takahito
authors.initials: T
authors.lastname: Kodama
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Naito
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yasunaga
authors.forename: Hisafumi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Masamichi
authors.initials: M
authors.lastname: Kojiro
mesh_terms: D000368:Aged; D018267:Carcinoma, Acinar Cell / Q000473:pathology*; D003135:Common Bile Duct / Q000473:pathology*; D003138:Common Bile Duct Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D010183:Pancreatic Ducts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*