Mechanisms of disease: erythropoietin--an old hormone with a new mission?
The major physiological function of erythropoietin is the induction of erythropoiesis. A growing body of evidence indicates, however, that this hormone has tissue-protective effects and prevents tissue damage during ischemia and inflammation. This review article summarizes the present knowledge on the cardiovascular and renal protective effects of erythropoietin and discusses the possible underlying mechanisms.
Fliser
Danilo
D
Hannover Medical School, Hannover, Germany.
Bahlmann
Ferdinand H
FH
deGroot
Kirsten
K
Haller
Hermann
H
D000740:Anemia / Q000188:drug therapy*; D002454:Cell Differentiation; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000187:drug effects; D004921:Erythropoietin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy*; D009203:Myocardial Infarction / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D032383:Myocytes, Cardiac / Q000187:drug effects; D011994:Recombinant Proteins; D015398:Signal Transduction; D013234:Stem Cells / Q000187:drug effects
D011994:Recombinant Proteins; D004921:Erythropoietin