title: Radionuclide imaging for the assessment of esophageal motility disorders in mixed connective tissue disease patients: relation to pulmonary impairment.
abstract: Esophageal functional abnormalities may lead to regurgitation, chronic esophagitis and life-threatening conditions such as aspiration pneumonia. In mixed connective tissue disease patients, previous reports showed that esophageal dysfunction varies according to the method employed for investigation. Our study was conceived to: (i) assess esophageal motility and mucosal aspects in patients with mixed connective tissue disease by endoscopy, cine-esophogram and scintigraphy focusing on the prevalence of each exam; and (ii) verify the association between pulmonary and esophageal dysfunctions. Twenty-four mixed connective tissue disease patients were enrolled for this study. Cine-esophogram and upper digestive endoscopy with mucosal biopsy were performed according to previous standardization. Radionuclide esophageal scintigraphy was performed with a semisolid meal with (99m)Tc. Eleven healthy individuals voluntarily submitted to scintigraphy as controls. Cine-esophogram showed esophageal delayed emptying in 90% of patients. At scintigraphy there was a significant delay in total esophageal transit time in the group of patients when compared to healthy controls (35.3 +/- 8.2 s. vs. 13.6 +/- 9.5 s.; P < 0.0001). The whole esophageal body showed dysmotility in 96% of patients. The cine-esophogram detected functional esophageal impairment similar to scintigraphic findings. Histopathologic examination found esophagitis in 95% of studied patients. Reduced lung volumes were associated with esophagitis and delayed esophageal clearance at scintigraphy, observed at the distal portion of the esophagus. Esophageal scintigraphy is easy to perform, with good acceptance by patients with low radiation exposition. It is a useful non-invasive test for follow-up and interventional studies concerning esophagus dysfunction.
authors.affiliation: Division of Rheumatology, Clinics Hospital, University of São Paulo, SP, Brazil. reumato@edu.usp.br
authors.forename: M T C
authors.initials: MT
authors.lastname: Caleiro
authors.forename: L V
authors.initials: LV
authors.lastname: Lage
authors.forename: T
authors.initials: T
authors.lastname: Navarro-Rodriguez
authors.forename: A
authors.initials: A
authors.lastname: Bresser
authors.forename: P A
authors.initials: PA
authors.lastname: da Costa
authors.forename: N H
authors.initials: NH
authors.lastname: Yoshinari
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003680:Deglutition Disorders / Q000209:etiology; D016145:Endoscopy, Digestive System; D015154:Esophageal Motility Disorders / Q000150:complications* / Q000000981:diagnostic imaging*; D004941:Esophagitis / Q000000981:diagnostic imaging; D005260:Female; D005756:Gastritis / Q000150:complications; D006356:Heartburn / Q000209:etiology; D006551:Hernia, Hiatal / Q000150:complications; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D009079:Mucociliary Clearance; D011877:Radionuclide Imaging; D012129:Respiratory Function Tests; D011795:Surveys and Questionnaires