title: Circadian rhythm abnormalities in the acute phase of cerebral infarction correlate with poor prognosis in the chronic phase.
abstract: The aim of this study was to determine circadian rhythm abnormalities in patients with acute cerebral infarction and their relationship with prognosis in the chronic phase. The subjects were 50 patients who were admitted within 48 h of onset. Rectal temperature and wrist motor activity were recorded during the acute phase. Time-series data were assayed by MEM spectral analysis. Functional prognosis (degree of handicap) was assessed at 3 months after stroke onset by the modified Rankin Scale. Ambulatory patients tended to exhibit circadian rhythm in rectal temperature and/or wrist activity rhythms, whereas non-ambulatory patients did not (P < 0.001) in the acute phase of ischemic stroke. Our findings suggest the biological rhythms of rectal temperature and wrist activity during the acute stroke phase might be a possible prognostic indicator of their chronic phase.
authors.affiliation: Department of Neurology, Dokkyo Medical University, Kitakobayashi 880, Tochigi 321-0293, Japan. takehide@k8.dion.ne.jp
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Takekawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001831:Body Temperature; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology; D021081:Chronobiology Disorders / Q000209:etiology* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D012189:Retrospective Studies; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013997:Time Factors; D014953:Wrist / Q000503:physiopathology