Catalytic enantioselective synthesis of adociacetylene B.
A catalytic enantioselective total synthesis of adociacetylene B (2) in five steps is reported. The efficiency of this synthesis was enabled by an asymmetric zinc alkynylation catalyzed by the proline-derived ligand (1).
Trost
Barry M
BM
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@stanford.edu
Weiss
Andrew H
AH
D000480:Alkynes / Q000138:chemical synthesis*; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D005663:Furans / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000480:Alkynes; D005663:Furans; C520939:adociacetylene B