title: Endomembrane proton pumps: connecting membrane and vesicle transport.
abstract: pH-homeostasis in the endomembrane system requires the activity of proton-pumps. In animals, the progressive acidification of compartments along the endocytic and secretory pathways is critical for protein sorting and vesicle trafficking, and is achieved by the activity of the vacuolar H(+)-ATPase (V-ATPase). Plants have an additional endomembrane pump, the vacuolar H(+)-pyrophosphatase (V-PPase), and previous research was largely focused on the respective functions of the two pumps in secondary active transport across the tonoplast. Recent approaches, including reverse genetics, have not only provided evidence that both enzymes play unique and essential roles but have also highlighted the important functions of the two proton pumps in endocytic and secretory trafficking.
authors.affiliation: ZMBP-Plant Physiology, Universität Tübingen, Auf der Morgenstelle 1, 72076 Tübingen, Germany. karin.schumacher@zmbp.uni-tuebingen.de
authors.forename: Karin
authors.initials: K
authors.lastname: Schumacher
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D010940:Plant Proteins / Q000378:metabolism*; D017494:Proton Pumps / Q000378:metabolism*; D022161:Transport Vesicles / Q000378:metabolism*
chemical_list: D010940:Plant Proteins; D017494:Proton Pumps; D000251:Adenosine Triphosphatases