Association of high alpha2-Heremans-Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass.
OBJECTIVE
Alpha2-Heremans-Schmid glycoprotein (AHSG; fetuin), a member of the cystatin superfamily of cysteine protease inhibitors involved in vascular pathology and bone metabolism, has been reported to be reduced in patients with atherosclerosis and medial calcification related to end stage renal disease or dialysis. No data on fetuin in patients with peripheral artery disease associated with low bone mass and normal renal function are available in the literature. In the present study we evaluated serum fetuin concentrations, bone mass, and markers of bone turnover in patients with atherosclerosis of peripheral vessels and normal kidney function.


METHODS
Ninety consecutive patients with evidence of atherosclerotic plaques at the common carotid or femoral artery were studied. Severity grade of disease was documented by ultrasound measurement of intima-media thickness (IMT). Fasting serum levels of fetuin were measured by sandwich enzyme immunoassay.


RESULTS
The mean patient serum concentration of fetuin was 57.68+/-13.6 ng/ml, significantly higher than that of control subjects (41.6+/-7.6 ng/ml; p<0.001). The mean serum concentration of bone-specific alkaline phosphatase (BAP) were 8.4+/-2.3 microg/l, significantly lower than controls (13.6+/-1.6 microg/l; p<0.001). Fetuin was correlated with IMT (r=0.8530; p<0.0001) and inversely correlated with BAP (r=-0.5503; p<0.0001). Patients had a vertebral and femoral bone mass significantly lower than controls.


CONCLUSIONS
This study documented for the first time that, in patients with atherosclerosis of peripheral vessels, serum fetuin levels were higher than in healthy subjects, and correlated with the severity of disease; further studies are required to analyse the role of AHSG as an independent predictor of atherosclerotic disease and low bone mass in patients with normal renal function.
Fiore
Carmelo E
CE
Department of Internal Medicine, University of Catania O.V.E., Catania, Italy. carmelo.fiore@tin.it
Celotta
Gabriella
G
Politi
Grazia G
GG
Di Pino
Luigi
L
Castelli
Zaira
Z
Mangiafico
Roberto A
RA
Signorelli
Salvatore S
SS
Pennisi
Pietra
P
D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000473:pathology*; D001798:Blood Proteins / Q000096:biosynthesis* / Q000737:chemistry; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000378:metabolism; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*; D014652:Vascular Diseases / Q000097:blood / Q000473:pathology*; D060749:alpha-2-HS-Glycoprotein; D000509:alpha-Fetoproteins / Q000096:biosynthesis* / Q000737:chemistry
C556354:AHSG protein, human; D001798:Blood Proteins; D006023:Glycoproteins; D060749:alpha-2-HS-Glycoprotein; D000509:alpha-Fetoproteins