The schizophrenic faces of PICK1.
Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia susceptibility gene. Here, we outline possible molecular mechanisms, discuss clinical case-studies that indicate an unexpected role of PICK1 in schizophrenia and discuss potential avenues for pharmacological manipulation of PICK1.
Dev
Kumlesh K
KK
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma, WSJ 386-7-43, Lichtstrasse 35, CH-4056 Basel, Switzerland. kumlesh_k.dev@novartis.com
Henley
Jeremy M
JM
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D051571:Protein Kinase C-alpha / Q000378:metabolism; D017434:Protein Structure, Tertiary; D019998:Racemases and Epimerases / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000099300:Serine Racemase
D014150:Antipsychotic Agents; D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D009687:Nuclear Proteins; D051571:Protein Kinase C-alpha; D019998:Racemases and Epimerases; D017470:Receptors, Glutamate; D000099300:Serine Racemase; C498297:PICk1 protein, human; C496628:PRKCA protein, human