title: The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats.
abstract: We investigated the effect of caffeic acid phenethyl ester in rat ileum injury induced by chronic biliary obstruction. Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, common bile duct ligation (n = 7); and Group 3, common bile duct ligation plus caffeic acid phenethyl ester (n = 7). In the caffeic acid phenethyl ester-treated rats, ileum tissue levels of malondialdehyde and myeloperoxidase were significantly lower than those of the bile duct-ligated rats (P < 0.001). The levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-1alpha in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). The present study demonstrates that intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative stress. This effect may be useful in the preservation of intestinal damage in cholestasis.
authors.affiliation: Department of General Surgery, Inonu University School of Medicine, 44069 Malatya, Turkey. cara@inonu.edu.tr
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ara
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Esrefoglu
authors.forename: Alattin
authors.initials: A
authors.lastname: Polat
authors.forename: Burak
authors.initials: B
authors.lastname: Isik
authors.forename: Murat
authors.initials: M
authors.lastname: Aladag
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Selma
authors.initials: S
authors.lastname: Ay
authors.forename: M Sait
authors.initials: MS
authors.lastname: Tekerleklioglu
authors.forename: Sezai
authors.initials: S
authors.lastname: Yilmaz
mesh_terms: D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D002109:Caffeic Acids / Q000494:pharmacology*; D001651:Cholestasis, Extrahepatic / Q000382:microbiology / Q000473:pathology*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D007082:Ileum / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D008643:Mesentery; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology
chemical_list: D002109:Caffeic Acids; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol