[Effects of styrene on the dopaminergic transmitter content and monoamine oxidase activity in different sections of rat brain].
OBJECTIVE
To observe the effect on dopaminergic transmitter content and of monoamine oxidase (MAO) activity at dose of experiment in different sections of rat brain exposed bu acutely and subacutely styrene.


METHODS
Rats were administrated orally with styrene of at dose of 600mg/kg for acute, 150, 300 and 600mg/kg for subacute experiment; recovery group were observed after 3 weeks exposure of styrene and intervened group were injected intraperitoneally at dose of 600mg/kg Levodopa (L-dopa) ; the urinary metabolites of styrene mandelic acid (MA) and phenylglyoxylic acid (PGA) were monitered as inner dosage, and the content of dopamine (DA) and activity of MAO were evaluated.


RESULTS
The result indicated that the content of urinary MA and PGA were associated with dosage positively, and MA may be more sensitive as inner dosage of styrene exposure since the background of PGA. Levels of DA in retina, hypophysis and striatum were decreased after styrene exposure, the activities of MAO in hypophysis were increased and were reduced in retina and striatum.


CONCLUSIONS
It was suggested dopaminergic system could be participated in styrene neurotoxicity.
Li
Bin
B
Institute of Occupational Health and Poison Control, China Center for Disease Control and Prevention, Beijing 100050, China.
Xiao
Jing-wei
JW
Wang
Hai-hua
HH
Li
Zhong-sheng
ZS
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D020058:Styrene / Q000633:toxicity*
D020058:Styrene; D008995:Monoamine Oxidase; D004298:Dopamine