title: Evidence of mechanoelectric feedback in the atria of patients with atrioventricular nodal reentrant tachycardia.
abstract: OBJECTIVE
  Patients with atrioventricular nodal reentrant tachycardia (AVNRT) could serve as a clinical model to study the effects of mechanical stretch in the electrical properties of atrial myocardium.
  
  
  METHODS
  We studied 14 patients with AVNRT. Peak, mean and minimal atrial pressures, atrial refractoriness (ERP) in the right atrial appendage and high right atrial lateral wall and monophasic action potential duration at 90% of repolarisation (MAPd90) in the right atrial appendage were assessed during atrial pacing at 500 and 400 ms and after 2 min of pacing at the tachycardia cycle length. Measurements were repeated from the same positions after ventricular pacing at the same cycle lengths and after 2 min of tachycardia. Susceptibility to atrial fibrillation (AF) was assessed by noting whether AF was induced during ERP evaluation.
  
  
  RESULTS
  Atrial pressure showed a statistically significant increase during ventricular pacing compared to baseline. This increase remained substantially unchanged when the tachycardia was induced. A significant reduction in atrial ERP and MAPd90 was also observed during ventricular pacing at all cycle lengths compared to atrial pacing. Two minutes of spontaneous tachycardia were enough to change the atrial ERP and MAPd90 to values significantly lower than those during atrial pacing at the cycle length of tachycardia. During the ERP evaluation AF was induced more often during the tachycardia (28%) than during ventricular (14%) and atrial pacing (0%).
  
  
  CONCLUSIONS
  In AVNRT patients, ventricular pacing and reentrant tachycardia significantly increase right atrial pressures and subsequently shorten ERP and MAPd90, leading to an enhanced propensity for AF.
authors.affiliation: Department of Cardiology, Heraklion University Hospital, 7100, Voutes, Heraklion-Crete, Greece.
authors.forename: Emmanuel G
authors.initials: EG
authors.lastname: Manios
authors.forename: Hercules E
authors.initials: HE
authors.lastname: Mavrakis
authors.forename: Emmanuel M
authors.initials: EM
authors.lastname: Kanoupakis
authors.forename: Eleftherios M
authors.initials: EM
authors.lastname: Kallergis
authors.forename: Panagiotis K
authors.initials: PK
authors.lastname: Kafarakis
authors.forename: Panos E
authors.initials: PE
authors.lastname: Vardas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001283:Atrioventricular Node / Q000503:physiopathology*; D004594:Electrophysiology; D005260:Female; D006325:Heart Atria / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013314:Stress, Mechanical; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000209:etiology* / Q000503:physiopathology*