title: Two cases of painful gynecomastia and lower extremity pain in association with pregabalin therapy.
abstract: We report two patients with refractory epilepsy who developed unilateral painful gynecomastia and lower extremity pain (one of them localized and the other one diffuse), shortly after receiving Pregabalin (PGB). Neither of them had previous endocrinologic problems or complaints about pain on their medical history. PGB was stopped in one patient and reduced in the other one, with complete disparition of the symptoms in the following weeks in both patients. This supports the hypothesis that gynecomastia could be a drug-induced and easy to manage secondary effect of PGB, with a higher incidence than observed on previous clinical trials.
authors.affiliation: Department of Pediatric Neurology, Hospital Universitario Sant Joan de Deu, Barcelona, Spain. imalaga@hsjdbcn.org
authors.forename: Ignacio
authors.initials: I
authors.lastname: Málaga
authors.forename: Francesc X
authors.initials: FX
authors.lastname: Sanmarti
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D004827:Epilepsy / Q000188:drug therapy*; D006177:Gynecomastia / Q000139:chemically induced*; D006801:Humans; D007085:Ilium / Q000473:pathology; D035002:Lower Extremity / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010146:Pain / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid