title: Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction.
abstract: OBJECTIVE
  The familial aggregation of Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction, jointly termed familial Barrett's esophagus, may represent a complex genetic trait. The aim of this study was to determine the proportion of patients with these diseases who have familial Barrett's esophagus.
  
  
  METHODS
  Information on gastroesophageal reflux symptoms, known risk factors for Barrett's esophagus, and family history of Barrett's esophagus and cancers, was collected at six hospitals using a structured questionnaire from probands with either long-segment Barrett's esophagus, adenocarcinoma of the esophagus, or adenocarcinoma of the gastroesophageal junction. Family history of Barrett's esophagus or esophageal cancer in a first- or second-degree relative was determined by reviewing medical records of all relatives reported to be affected.
  
  
  RESULTS
  Seventy one of 411 (17.3%) probands reported an affected first- and/or second-degree relative. Upon review of medical records of the reportedly affected relatives, familial Barrett's esophagus was definitively determined in the case of 30 (7.3%) probands comprising 17 of 276 (6.2%) with Barrett's esophagus, 11 of 116 (9.5%) with adenocarcinoma of the esophagus, and 2 of 21 (9.5%) with adenocarcinoma of the gastroesophageal junction. The diagnosis in the relative reported by the proband to be affected was found not to be Barrett's esophagus or adenocarcinoma in 15 (3.6%) cases. The diagnosis could not be determined in 26 (6.3%) cases in which the proband reported an affected relative. There were no significant differences in age of disease onset, gender, race, or gastroesophageal reflux symptoms between definitive familial Barrett's esophagus probands and nonfamilial probands.
  
  
  CONCLUSIONS
  Familial Barrett's esophagus can be confirmed in 7.3% of persons presenting with Barrett's esophagus, adenocarcinoma of the esophagus, or adenocarcinoma of the gastroesophageal junction.
authors.affiliation: University Hospitals of Cleveland, Case School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA. Amitabh.chak@case.edu
authors.forename: Amitabh
authors.initials: A
authors.lastname: Chak
authors.forename: Heather
authors.initials: H
authors.lastname: Ochs-Balcom
authors.forename: Gary
authors.initials: G
authors.lastname: Falk
authors.forename: William M
authors.initials: WM
authors.lastname: Grady
authors.forename: Margaret
authors.initials: M
authors.lastname: Kinnard
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Willis
authors.forename: Robert
authors.initials: R
authors.lastname: Elston
authors.forename: Charis
authors.initials: C
authors.lastname: Eng
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics*; D000368:Aged; D001471:Barrett Esophagus / Q000235:genetics*; D015992:Body Mass Index; D004938:Esophageal Neoplasms / Q000209:etiology / Q000235:genetics*; D004943:Esophagogastric Junction; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors