title: Effects of vitamin E supplementation on oxidative stress at rest and after exercise to exhaustion in athletic students.
abstract: OBJECTIVE
  The purpose of this study is to determine the effect following exercise to exhaustion of vitamin E supplementation on oxidative stress in athletic students.
  
  
  METHODS
  Twenty male students voluntarily participated in the study and were randomly assigned (double blind) to either a vitamin E (daily dose of 450 mg of a-tocopherol for a period of 8 weeks) or a placebo group (took capsules containing 450 mg of lactose for 8 weeks). Before and after 8 weeks blood samples were collected at rest and after exercise to exhaustion. Oxidative stress markers were malondialdehyde (MDA), carbonylated proteins (CP) and creatine kinase (CK). Also, the effect of vitamin E on ergometer cycling time, as an example of endurance performance, was evaluated.
  
  
  RESULTS
  ANOVA and independent t-tests indicated that vitamin E supplementation did not significantly change (P > 0.05) MDA, CP and CK values at rest, after exercise to exhaustion, and cycling time, but plasma volume after exercise to exhaustion significantly decreased (P < 0.05).
  
  
  CONCLUSIONS
  Although vitamin E supplementation had no effect on exercise performance or capacity in athletic students, further investigation is required using larger numbers of subjects and measures of vitamin E before unequivocal conclusion can be stated.
authors.affiliation: Faculty of Physical Education, University of Tehran, Tehran, Iran.
authors.forename: A A
authors.initials: AA
authors.lastname: Gaeini
authors.forename: N
authors.initials: N
authors.lastname: Rahnama
authors.forename: M R
authors.initials: MR
authors.lastname: Hamedinia
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000008:administration & dosage*; D003402:Creatine Kinase / Q000097:blood / Q000187:drug effects; D019587:Dietary Supplements; D004311:Double-Blind Method; D016552:Ergometry; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018763:Muscle Fatigue / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects; D010953:Plasma Volume / Q000187:drug effects; D050050:Protein Carbonylation / Q000187:drug effects; D012146:Rest / Q000502:physiology*; D013177:Sports; D013334:Students; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D003402:Creatine Kinase