The effects of hyperbaric oxygen treatment on lipid peroxidation of pregnant rabbits and their fetus during late pregnancy.
OBJECTIVE
To measure the effects of hyperbaric oxygen on lipid peroxidation of pregnant and fetal rabbits during late pregnancy.


METHODS
Sixteen pregnant rabbits were randomly and equally divided into two groups. One, the HBO2 group, was exposed to 2-atm oxygen for 60 min a day from the 21st to the 30th day of gestation, and the other group, non-HBO2 group, did not obtain any hyperbaric oxygen treatment.


RESULTS
On the 30th day of pregnant period, the activity of antioxidant enzyme SOD in plasma of the pregnant rabbits of the HBO2 group was significantly higher than that of the non-HBO2 group, but there was no significant difference in the level of oxidative stress marker 8-iso-PG-F2 alpha between the two groups. As for the fetal rabbits, the SOD activity in umbilical plasma, placenta tissue and fetal brain tissue of HBO2 group was significantly higher than that of the non-HBO2 group, while there was no statistical difference between the concentrations of 8-iso-PG-F2 alpha of HBO2 and non-HBO2 group.


CONCLUSIONS
HBO2 treatment during the late pregnancy up-regulates the activity of antioxidant enzyme in plasma of pregnant rabbits, placenta, umbilical plasma, and fetal brain. This does not have significant effect on the oxidative stress in these tissues.
Xiao
X M
XM
Dept. of Gynecology & Obstetrics, First Affiliated Hospital of Jinan University, Guangzhou, P.R. China.
Ye
Z H
ZH
Long
Y
Y
Chen
S L
SL
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D015227:Lipid Peroxidation / Q000187:drug effects*; D010100:Oxygen / Q000494:pharmacology*; D011247:Pregnancy; D011817:Rabbits; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000097:blood*
D013482:Superoxide Dismutase; D010100:Oxygen