title: Adiponectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidism.
abstract: OBJECTIVE
  Adiponectin, an adipose tissue-derived hormone, has been reported to have anti-inflammatory and anti-atherogenic effects. The physiological effect of adiponectin on the metabolic changes and its relation with cardiovascular risk factors in thyroid dysfunction states is still not clear. The aim of the study was to evaluate plasma adiponectin level and its relation to cardiovascular risk factors in patients with thyroid dysfunction.
  
  
  METHODS
  Sixty-seven patients with hypothyroidism, 56 patients with hyperthyroidism and 52 age- and sex-matched euthyroid subjects were enrolled in the study. Adiponectin, C-reactive protein (CRP), homocysteine (Hcy), lipid parameters, Lipoprotein(a) [Lp (a)], Apolipoprotein (Apo) A, Apo B and fibrinogen levels were measured in all subjects. Insulin sensitivity was determined using the Homeostasis Model Assessment (HOMA-IR).
  
  
  RESULTS
  Circulating adiponectin levels were not different between the groups (16.2 +/- 5.0, 15.1 +/- 3.7, 15.9 +/- 4.8 ng/ml; hypothyroid, hyperthyroid, euthyroid group, respectively). Plasma adiponectin levels correlated negatively with body mass index (BMI) and HOMA-IR index and positively with high-density lipoprotein cholesterol (HDL-C) in all groups. There was a significant correlation between adiponectin and CRP levels in both hypothyroid and hyperthyroid groups. In all groups, adiponectin levels did not correlate with age, systolic blood pressure, diastolic blood pressure and thyroid hormones. Multiple regression analysis revealed BMI and HDL-C levels to be the most important predictors of circulating adiponectin levels.
  
  
  CONCLUSIONS
  Plasma adiponectin levels are associated with BMI and HDL-C levels in patients with hypothyroidism and hyperthyroidism. But there is not a direct relation of adiponectin with thyroid hormones in these patients.
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey. alevaltinova@yahoo.com
authors.forename: Alev E
authors.initials: AE
authors.lastname: Altinova
authors.forename: Füsun B
authors.initials: FB
authors.lastname: Törüner
authors.forename: Müjde
authors.initials: M
authors.lastname: Aktürk
authors.forename: Neslihan
authors.initials: N
authors.lastname: Bukan
authors.forename: Nuri
authors.initials: N
authors.lastname: Cakir
authors.forename: Göksun
authors.initials: G
authors.lastname: Ayvaz
authors.forename: Metin
authors.initials: M
authors.lastname: Arslan
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001055:Apolipoproteins B / Q000032:analysis; D053241:Apoprotein(a) / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications*; D007037:Hypothyroidism / Q000097:blood / Q000150:complications*; D007333:Insulin Resistance; D017270:Lipoprotein(a) / Q000032:analysis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D001055:Apolipoproteins B; D015415:Biomarkers; D008076:Cholesterol, HDL; D017270:Lipoprotein(a); D006710:Homocysteine; D005340:Fibrinogen; D002097:C-Reactive Protein; D053241:Apoprotein(a)