Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer.
It is well established that cancers affect differentiation of dendritic cells and promote systemic expansion of immune suppressive immature myeloid cells. This phenomenon may represent a mechanism of tumor escape from immune attack and could have significant impact on tumor progression. In this review we discuss the role of different tumor-derived factors, which were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed.
Kusmartsev
Sergei
S
H. Lee Moffitt Cancer Center, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA. kusmars@moffitt.usf.edu
Gabrilovich
Dmitry I
DI
D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D053612:Janus Kinases / Q000502:physiology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D022423:Myeloid Cells / Q000166:cytology* / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D050791:STAT Transcription Factors / Q000502:physiology; D019139:Tumor Escape
D016207:Cytokines; D050791:STAT Transcription Factors; D053612:Janus Kinases