[Expression of the selected adhesive molecules (cadherin E, CD44, LGAL3 and CA50) in papillary thyroid carcinoma].
BACKGROUND
The aim of the study was to determine the expression of selected adhesive molecules in papillary thyroid carcinoma.


METHODS
47 papillary thyroid carcinoma cases and 11 nonmalignant goiter cases were analyzed by immunohistochemistry.


RESULTS
Galectin-3 (LGAL3) was a sensitive and specific marker, present in 91% of analyzed tumors and only in 5% of tumor margin. The presence of CA50 was 86% and 3% respectively with only 3% positive non-malignant cases. Cadherin E expression was noted in 91% of primary tumors, in 84% of the surrounding tissue and in 63% of non-malignant goiter. CD44 (DF1485) was observed in 89% of primary tumors and 48% of surrounding tissue; the reaction with BBA10 was more characteristic for metastases.


CONCLUSIONS
Our study confirms the high diagnostic value of galectin-3 in papillary thyroid carcinoma and reveals the similar efficiency of CA50. CD44 (DF1485) expression in primary tumor is more intensive than in surrounding tissue, but the diagnostical inportance is not high because it is often observed in benign lesions. Using of BBA10 is more sensitive, but less specific. High expression of cadherin E in benign lesions impairs its diagnostical application in papillary thyroid cancer.
Nikiel
Barbara
B
Department of Tumor Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice. basia-ni@o2.pl
Chekan
Mykola
M
Jaworska
Magdalena
M
Jarzab
Michał
M
Maksymiuk
Beata
B
Lange
Dariusz
D
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000032:analysis; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D037502:Galectin 3 / Q000032:analysis; D006042:Goiter / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D007150:Immunohistochemistry; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C082699:CA-50 antigen; D015820:Cadherins; D037502:Galectin 3; D018960:Hyaluronan Receptors