Moxifloxacin distribution in the interstitial space of infected decubitus ulcer tissue of patients with spinal cord injury measured by in vivo microdialysis.
We investigated the distribution of moxifloxacin in the interstitial space of normal and infected subcutaneous tissue in patients with spinal cord injury and decubitus ulcers using in vivo microdialysis. Drug concentrations achieved in serum, saliva, normal and infected tissues showed approximately parallel time profiles. The interstitial tissue fluids reached bactericidal levels for common bacteria found in infected skin lesions. Our findings suggest that moxifloxacin exhibits good and similar penetration into the interstitial space fluid in normal subcutaneous tissue and infected decubitus ulcers in patients with spinal cord injury.
Burkhardt
Olaf
O
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA. burkhardt.olaf@mh-hannover.de
Derendorf
Hartmut
H
Jäger
Doris
D
Kumar
Vipul
V
Madabushi
Rajanikanth
R
Röhl
Klaus
K
Barth
Jürgen
J
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001372:Aza Compounds / Q000097:blood / Q000493:pharmacokinetics*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D017551:Microdialysis / Q000379:methods; D008875:Middle Aged; D000077266:Moxifloxacin; D003668:Pressure Ulcer / Q000209:etiology / Q000378:metabolism*; D011804:Quinolines / Q000097:blood / Q000493:pharmacokinetics*; D013119:Spinal Cord Injuries / Q000150:complications*; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin