Delayed effects of enalapril on structural characteristics of the glomerular apparatus in the kidneys of NISAG rats.
Structural characteristics of renal glomeruli were studied in adult hypertensive NISAG rats (hereditary stress-induced hypertension) receiving antihypertensive drug enalapril, an inhibitor of angiotensin-converting enzyme, on days 28-58 of life. Treatment with enalapril (25 mg/kg perorally) in the early period of postnatal ontogeny produced delayed hypotensive and nephroprotective effects.
Filyushina
E E
EE
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. e.e.filjushina@iph.ma.nsc.ru
Shmerling
M D
MD
Lazarev
V A
VA
Buzueva
I I
II
Kudryashova
D R
DR
Markel
A L
AL
Yakobson
G S
GS
D000367:Age Factors; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000150:complications; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004656:Enalapril