title: Significant reduction in blood loss in patients undergoing minimal extracorporeal circulation.
abstract: Several recent studies have shown differences in blood loss and allogeneic transfusion requirements between on-pump and off-pump coronary artery bypass grafting (CABG). Recently a new concept, the mini-extracorporeal circulation, was introduced to minimize the side effects of extracorporeal circulation. Therefore, there are no data comparing the three techniques with special emphasis to blood loss and transfusion requirements. Two hundred and eighty-five patients undergoing first-time coronary artery bypass grafting were retrospectively matched for number of grafts, age and sex. Ninety-five patients underwent surgery with the off-pump CABG (OPCAB) technique, 97 patients using conventional CABG with cold cardioplegia (CCABG) and 93 patients with the mini-extracorporeal circuit with warm blood cardioplegia (MCABG). Blood loss for the CCABG group with a mean loss of 819 +/- 557 mL and the OPCAB group with a mean loss of 870 +/- 768 mL was significant different compared to the MCABG group with a mean loss of 679 +/- 290 mL. The use of units red blood cell units was significantly higher for CCABG group and OPCAB group compared to the MCABG group. On the day of operation the use of platelet concentrate was significantly higher for the CCABG group compared to MCABG group. As a consequence of improvements of several components of the mini heart lung machine, significantly less blood products are needed in MCABG patients. The expected reduced need for transfusion when the pump was completely avoided could not be confirmed in this single retrospective cohort study.
authors.affiliation: Department of Clinical Chemistry, St Antonius Hospital, Nieuwegein, The Netherlands. w.gerritsen@antonius.net
authors.forename: W B
authors.initials: WB
authors.lastname: Gerritsen
authors.forename: W J
authors.initials: WJ
authors.lastname: van Boven
authors.forename: R M
authors.initials: RM
authors.lastname: Wesselink
authors.forename: M
authors.initials: M
authors.lastname: Smelt
authors.forename: W J
authors.initials: WJ
authors.lastname: Morshuis
authors.forename: H P
authors.initials: HP
authors.lastname: van Dongen
authors.forename: F J
authors.initials: FJ
authors.lastname: Haas
authors.forename: L P
authors.initials: LP
authors.lastname: Aarts
mesh_terms: D000368:Aged; D016913:Blood Component Transfusion / Q000706:statistics & numerical data; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D015331:Cohort Studies; D003080:Cold Temperature / Q000009:adverse effects; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D005112:Extracorporeal Circulation / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects* / Q000379:methods; D006454:Hemoglobins / Q000032:analysis; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods; D012189:Retrospective Studies
chemical_list: D006454:Hemoglobins