title: Granulomatous balanoposthitis after intravesical Bacillus-Calmette-Guerin instillation therapy.
abstract: We report a rare case of granulomatous balanoposthitis after intravesical Bacillus-Calmette-Guerin (BCG) instillation therapy in a 58-year-old man, which followed transurethral resection (TUR) for recurrent bladder cancer, when his anterior urethra was slightly narrow and his foreskin was with phimosis. Intravesical BCG instillation therapy was started for prophylaxis of recurrent bladder cancer after TUR. Multiple painless firm papules on glans penis, edema in the foreskin and low-grade fever appeared after the seventh instillation, for which the single antituberculous agent isoniazid (300 mg/day) was administered. Biopsy of the papules on glans penis and foreskin revealed granulomatous balanoposthitis. Low-grade fever normalized and the papules disappeared within 1 week. The patient continued chemotherapy with isoniazid for the next 12 months. There was no recurrence of bladder cancer or balanoposthitis for 15 months and to date.
authors.affiliation: Odawara Municipal Hospital Urology, Odawara, Kanagawa, Japan. hatu98@yahoo.co.jp
authors.forename: Hattori
authors.initials: H
authors.lastname: Yusuke
authors.forename: Hara
authors.initials: H
authors.lastname: Yoshinori
authors.forename: Matsuura
authors.initials: M
authors.lastname: Kenichi
authors.forename: Hasegawa
authors.initials: H
authors.lastname: Akio
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000283:Administration, Intravesical; D000995:Antitubercular Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001446:Balanitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D001706:Biopsy; D005500:Follow-Up Studies; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007322:Instillation, Drug; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D001500:BCG Vaccine; D007538:Isoniazid