title: [Granulomatous hepatitis successfully treated with ursodeoxycholic acid].
abstract: The etiology of granulomatous hepatitis is extremely extensive for which the granulomatous reaction induced hepatic inflammation is characteristic. In the majority of cases it is part of a systemic disease but sometimes there is primer hepatic lesion in the background. The 21 year-old Caucasian female patient was taken to hospital having flu-like symptoms and icterus. While searching for the cause of her cholestatic hepatocellular lesion infections, tumors, storage diseases were excluded. However the root cause could not be identified. The histology showed granulomatous reaction, inflammation, intrahepatic bile duct proliferation and micronodular cirrhosis in the liver tissue. Taken it into consideration together with the the clinical picture and the laboratory findings primer sclerosing cholangitis was rendered probable. Her state deteriorated and even the necessity of liver transplantation emerged. The patient was treated with ursodeoxycholic acid which resulted in remission lasting for years now. Two years after the onset of the hepatic disease pancolitis ulcerosa with affection of the ileum terminalis was found in the patient which supports the diagnosis of primary sclerosing cholangitis.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika. eszternemeth@freemail.hu
authors.forename: Eszter
authors.initials: E
authors.lastname: Németh
authors.forename: Elemér
authors.initials: E
authors.lastname: Bugovics
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lengyel
authors.forename: Gyula
authors.initials: G
authors.lastname: Pécsi
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Schaff
authors.forename: János
authors.initials: J
authors.lastname: Fehér
mesh_terms: D000328:Adult; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D005260:Female; D006099:Granuloma; D006505:Hepatitis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D006801:Humans; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid