title: Prior heart failure among patients with acute coronary syndromes is associated with a higher incidence of in-hospital heart failure.
abstract: BACKGROUND
  There are few data regarding the impact of prior heart failure (P-HF) on the presentation, course and outcomes of acute coronary syndromes (ACS).
  
  
  RESULTS
  We prospectively analyzed all ACS patients admitted in all cardiology wards in Israel during February and March, 2004. Of the 2098 patients, 156(7.4%) had P-HF. These patients were older (75 [66.5-81] versus 63 [53-74] years, (P<0.001)) and more often female (38.5% versus 25.0%, P<0.001)), with a higher prevalence of coronary artery disease risk factors, prior cardiac disease and procedures, and other co-morbidities. They more often presented with atypical angina and heart failure and less with ST-elevation (18.6% versus 51.3%, p<0.0001). In-hospital heart failure developed more frequently (15.4% versus 6.1%, p = 0.00001), including cardiogenic shock (7.1% versus 2.9%, p = 0.005), as did persistent atrial fibrillation (6.4% versus 0.7%, p<0.001), but not ischemic complications. After adjustment for differences, P-HF was not independently associated with 30 day or six-month mortality, but at one-year follow-up, it was (OR 1.16, 95% CI 1.0-2.5). P-HF was also independently associated with increased incidence of heart failure upon admission or thereafter in-hospital (OR = 4.3, 95% CI 2.8-6.6).
  
  
  CONCLUSIONS
  P-HF ACS patients had high-risk features, lower incidence of ST-elevation, and higher one-year adjusted mortality. P-HF was also independently associated with in-hospital heart failure, suggesting they should be monitored vigilantly.
authors.affiliation: Department of Cardiology, Rabin Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: Zaza
authors.initials: Z
authors.lastname: Iakobishvili
authors.forename: Micha S
authors.initials: MS
authors.lastname: Feinberg
authors.forename: Vladimir
authors.initials: V
authors.lastname: Danicek
authors.forename: Solomon
authors.initials: S
authors.lastname: Behar
authors.forename: Doron
authors.initials: D
authors.lastname: Zahger
authors.forename: Hanoch
authors.initials: H
authors.lastname: Hod
authors.forename: Amir
authors.initials: A
authors.lastname: Sandach
authors.forename: Haim
authors.initials: H
authors.lastname: Hammerman
authors.forename: Alex
authors.initials: A
authors.lastname: Sagie
authors.forename: Aviv
authors.initials: A
authors.lastname: Mager
authors.forename: Shmuel
authors.initials: S
authors.lastname: Gottlieb
authors.forename: David
authors.initials: D
authors.lastname: Hasdai
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003327:Coronary Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality*; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009026:Mortality; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013577:Syndrome