Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.
Klar
Ulrich
U
Schering AG, Research Center Europe, Müllerstrasse 178, 13342 Berlin, Germany. ulrich.klar@schering.de
Buchmann
Bernd
B
Schwede
Wolfgang
W
Skuballa
Werner
W
Hoffmann
Jens
J
Lichtner
Rosemarie B
RB
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003500:Cyclization; D034261:Epothilones / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D034261:Epothilones; C005412:pantolactone; C430592:ixabepilone; D015107:4-Butyrolactone