title: High plasma concentration of remnant lipoprotein cholesterol in obese children and adolescents.
abstract: OBJECTIVE
  Remnant lipoproteins (RLPs) are the products of the lipolytic degradation of triglyceride-rich lipoproteins produced by the liver and intestine. Recent studies have demonstrated that RLPs are correlated with cardiovascular risk. We assessed the relationship between obesity and RLP and evaluated the factors related to RLP in children and adolescents.
  
  
  METHODS
  We measured BMI, waist circumference, blood pressure, body fat mass, total abdominal fat, visceral and subcutaneous fat areas, fasting glucose, insulin, total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, and RLP cholesterol in 135 children and adolescents (67 boys and 68 girls). Plasma RLP fractions were isolated using an immunoaffinity gel containing specific anti-apolipoprotein (apo) B-100 and anti-apoA-I antibodies. Based on the BMI percentile, the subjects were divided into two groups: normal (< 85th percentile) and overweight (> or = 85th percentile).
  
  
  RESULTS
  RLP cholesterol was significantly correlated with age, sex, BMI, waist circumference, systolic and diastolic blood pressures, visceral and subcutaneous fat areas, visceral-to-subcutaneous fat area ratio, total cholesterol, triglycerides, HDL cholesterol, apoB, and homeostasis model assessment of insulin resistance (HOMA-IR). According to the multivariate regression analysis, triglycerides (beta = 0.928, P < 0.001) were independently correlated with RLP cholesterol. After excluding lipid profiles as an independent variable, the multivariate regression analysis revealed that HOMA-IR (beta = 0.231, P = 0.007) and systolic blood pressure (beta = 0.169, P = 0.046) were independently associated with RLP cholesterol.
  
  
  CONCLUSIONS
  RLP cholesterol was significantly higher in obese children and adolescents. Triglycerides, systolic blood pressure, and insulin resistance were related to RLP cholesterol.
authors.affiliation: Department of Endocrinology and Metabolism, Ajou University School of Medicine, San-5 Wonchon-Dong, Yongtong-Gu, Suwon 443-721, Republic of Korea.
authors.forename: Yong Jun
authors.initials: YJ
authors.lastname: Choi
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Jo
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Sang Mi
authors.initials: SM
authors.lastname: Ahn
authors.forename: Sun Hye
authors.initials: SH
authors.lastname: Jung
authors.forename: Hae Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Yoon-Sok
authors.initials: YS
authors.lastname: Chung
authors.forename: Kwan Woo
authors.initials: KW
authors.lastname: Lee
authors.forename: Dae Jung
authors.initials: DJ
authors.lastname: Kim
mesh_terms: D050153:Abdominal Fat / Q000033:anatomy & histology; D000293:Adolescent; D053299:Apolipoprotein B-100 / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D015243:Cholesterol, VLDL / Q000097:blood*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D050152:Intra-Abdominal Fat / Q000033:anatomy & histology; D007723:Korea; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D050151:Subcutaneous Fat / Q000033:anatomy & histology; D014280:Triglycerides / Q000097:blood
chemical_list: D053299:Apolipoprotein B-100; D015243:Cholesterol, VLDL; D014280:Triglycerides