Efficacy of suppository analgesia in postabortion pain reduction.
OBJECTIVE
Termination of pregnancy is a painful procedure. Currently, there are no sufficient data regarding the best mode to reduce this pain. The aim of the study was to evaluate postabortion pain levels and to examine the analgesic effect of three different generic types of suppositories provided at the end of the surgical procedure prior to awakening from general anesthesia.


METHODS
Two hundred seventeen women were randomly assigned to four groups: indomethacin (100 mg), paracetamol (1000 mg), tramadol (100 mg), and control group with no suppository treatment. Pain levels were evaluated by VAS five times--15, 30, 60, 90 and 120 min after abortion. The number of doses of rescue analgesia with dipyrone (1 g po) was recorded.


RESULTS
There was a significant difference in pain levels between the four groups during the 2-h study (p<.05). Indomethacin always had the lowest VAS rank. Rescue analgesia was requested by 22/55 women in the control group, 10/55 in the tramadol group, 7/54 in the paracetamol group and 5/53 in the indomethacin group (chi(2)=19.0, p<.0001).


CONCLUSIONS
The application of a single suppository of an analgesic drug, especially indomethacin, is a simple, inexpensive and safe mode to reduce postabortion pain.
Lowenstein
Lior
L
Department of Obstetrics and Gynecology, Rambam Medical Center and the Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Granot
Michal
M
Tamir
Ada
A
Glik
Aldo
A
Deutsch
Michael
M
Jakobi
Peter
P
Zimmer
Etan Z
EZ
D000082:Acetaminophen / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000359:Aftercare / Q000379:methods*; D000698:Analgesia / Q000379:methods*; D000700:Analgesics / Q000008:administration & dosage*; D004333:Drug Administration Routes; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage; D010147:Pain Measurement / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013488:Suppositories / Q000008:administration & dosage; D013997:Time Factors; D014147:Tramadol / Q000008:administration & dosage
D000700:Analgesics; D013488:Suppositories; D000082:Acetaminophen; D014147:Tramadol; D007213:Indomethacin