Acid-catalyzed synthesis of methylene-bridged (S)-tyrosine-phenol dimers.
The efficient synthesis of 2,2'-arylmethylene dimers from 3-hydroxymethyl or 3-methoxymethyl-5-halo-(S)-tyrosines and para-substituted phenols under acid-catalyzed reaction conditions using either conventional or microwave-assisted protocols is described.
Bew
Sean P
SP
School of Chemical Sciences & Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK. s.bew@uea.ac.uk
Hughes
David L
DL
Sharma
Sunil V
SV
D000143:Acids; D002384:Catalysis; D019281:Dimerization; D008872:Microwaves; D010636:Phenols / Q000138:chemical synthesis*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D000143:Acids; D010636:Phenols; D014443:Tyrosine