Anti-beta2 glycoprotein 1 and the anti-phospholipid syndrome.
OBJECTIVE
To describe a patient who presented with bilateral retinal vascular occlusion and the use of anti-beta2 glycoprotein 1 (GPI) antibody testing in the diagnosis of antiphospholipid syndrome.


METHODS
Observational case report.


METHODS
Hematological investigations were performed on a 49-year-old man who presented with rapid onset of bilateral severe central retinal vein occlusion.


RESULTS
Lupus anticoagulant and anticardiolipin antibody testing was negative. Markedly raised titers of anti-beta2 GPI antibodies were detected on two separate occasions.


CONCLUSIONS
The raised titers of anti-beta2 GPI antibodies were considered to strongly suggest an underlying diagnosis of the antiphospholipid syndrome.
Keane
Pearse A
PA
Department of Ophthalmology, Cork University Hospital, Cork, Ireland. pearsek@iol.ie
Ravikumar
Kesavan
K
O'shea
Susan I
SI
Cleary
Philip E
PE
D017153:Antibodies, Anticardiolipin / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000175:diagnosis*; D001053:Apolipoproteins / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D001766:Blindness / Q000473:pathology; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000175:diagnosis*; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D001053:Apolipoproteins; D001323:Autoantibodies; D006023:Glycoproteins; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I