Study on synthesis and biological activity of a galactosylated piperazinyl porphyrin.
In order to obtain an carcinoma-selective drug, the synthesis and characterization of 5,10,15,20-tetra[4-(4'-galactosylpiperazinyl)phenyl]porphyrin (TGPP) is reported. The biological activity on cancer cells and the pharmacokinetics are also reported as preliminary results showing a very high liver to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.
Li
He-Ping
HP
College of Chemical and Environmental Engineering, Changsha University of Science and Technology, Changsha 410076, China. lihepinghn@163.com
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D005697:Galactosides; D051379:Mice; D008958:Models, Molecular; D010879:Piperazines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D005697:Galactosides; D010879:Piperazines; D011166:Porphyrins