Synthesis and herbicidal activity of N,N-diethyl-3-(arylselenonyl)-1H-1,2,4-triazole-1-carboxamide.
Based on the carbamoyl triazole herbicide Cafenstrole, 12 novel selenium-containing compounds were designed and synthesized. All of the compounds were characterized and confirmed by IR, 1H NMR, and high-resolution mass spectroscopy. The bioassay tests showed that some of the compounds (C2, C4, C(7-8), and C12) exhibited good inhibitory activity against cucumber (Cucumis sativus L.) and semen euphorbiae (Leptochloa chinensis N.). Especially, compound C6 inhibited the growth of cucumber and semen euphorbiae by >90% at a concentration of 1.875 microg/mL, and the inhibition of the compound on the rice (Oryza sativa L.) was only 8.3% at a concentration of 7.5 microg/mL, which indicated a higher selectivity between weed and rice than that shown by Cafenstrole.
Ma
Yanming
Y
Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, PO Box 544, Shanghai 200237, People's Republic of China.
Liu
Runhui
R
Gong
Xiuying
X
Li
Zhong
Z
Huang
Qingchun
Q
Wang
Haishui
H
Song
Gonghua
G
D018553:Cucumis sativus / Q000187:drug effects; D019665:Euphorbiaceae; D006540:Herbicides / Q000138:chemical synthesis* / Q000494:pharmacology; D012275:Oryza / Q000187:drug effects; D006109:Poaceae / Q000187:drug effects; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D006540:Herbicides; D013450:Sulfones; D014230:Triazoles; C444649:cafenstrole