Caspase-1 builds a new barrier to infection.
Caspase-1 promotes both the maturation of proinflammatory cytokines and apoptosis in cells infected by certain pathogens. Work by now reveals a surprising new function for caspase-1: the stimulation of membrane biogenesis to repair damage caused by bacterial pore-forming toxins. Thus, caspase-1 may promote host cell survival as a means of resistance to pathogenic bacteria.
Saleh
Maya
M
Department of Medicine, McGill University, Montreal H3G 1Y6, Canada. maya.saleh@mcgill.ca <maya.saleh@mcgill.ca>
D000818:Animals; D001424:Bacterial Infections / Q000201:enzymology* / Q000503:physiopathology; D001427:Bacterial Toxins / Q000378:metabolism; D020170:Caspase 1 / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism*; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D051779:Sterol Regulatory Element Binding Proteins / Q000378:metabolism
D001427:Bacterial Toxins; D008563:Membrane Lipids; D051779:Sterol Regulatory Element Binding Proteins; D020170:Caspase 1