Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia.
To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality.
Dessing
Mark C
MC
Center for Experimental and Molecular Medicine, Room F0-117, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. m.c.dessing@amc.uva.nl
de Vos
Alex F
AF
Florquin
Sandrine
S
van der Poll
Tom
T
D000818:Animals; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D007109:Immunity / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D011018:Pneumonia, Pneumococcal / Q000235:genetics / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000254:growth & development / Q000302:isolation & purification
D018932:Chemokine CCL2