Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.
Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production.
Miethke
Marcus
M
Fachbereich Chemie/Biochemie der Philipps-Universität Marburg, Marburg, Germany.
Westers
Helga
H
Blom
Evert-Jan
EJ
Kuipers
Oscar P
OP
Marahiel
Mohamed A
MA
D000596:Amino Acids / Q000096:biosynthesis*; D001412:Bacillus subtilis / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003470:Culture Media; D004952:Esters; D015964:Gene Expression Regulation, Bacterial; D007501:Iron / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D009842:Oligopeptides / Q000096:biosynthesis*; D020543:Proteome; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D000596:Amino Acids; D001426:Bacterial Proteins; D003470:Culture Media; D004952:Esters; D009842:Oligopeptides; D020543:Proteome; D012097:Repressor Proteins; C430721:bacillibactin; C068477:ferric uptake regulating proteins, bacterial; D007501:Iron