title: [Neuromuscular blocking effects of Org 9426 (rocuronium bromide); a comparative study with vecuronium bromide in Japanese patients].
abstract: BACKGROUND
  Efficacy and safety of Org 9426 were compared with those of vecuronium bromide in Japanese patients.
  
  
  METHODS
  We studied 88 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of 0.6 mg x kg(-1), 0.9 mg x kg(-1) of Org 9426 or 0.1mg x kg(-1) of vecuronium. Following an intubation dose, patients received maintenance doses of 0.1, 0.15 or 0.2 mg x kg(-1) of Org 9426 or 0.025 mg x kg(-1) of vecuronium. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation.
  
  
  RESULTS
  The onset times of the 0.6 and 0.9 mg x kg(-1) of Org 9426 groups were 84.6 and 77.1 sec respectively, which showed statistical difference between the onset time of 0.1 mg x kg(-1) of vecuronium, 125.7 sec. The intubation condition was similar among three treatment groups. The clinical durations of 0.6 and 0.9 mg x kg(-1) of Org 9426 and 0.1 mg x kg(-1) of vecuronium were 53.4, 73.4 and 59.9 min, respectively. Clinical duration and spontaneous recovery time of maintenance dose of 0.15 mg x kg(-1) of Org 9426 were similar to those of 0.025 mg x kg(-1) of vecuronium.
  
  
  CONCLUSIONS
  Org 9426 showed more rapid onset time than that of vecuronium and similar clinical duration and recovery times to those of vecuronium in Japanese patients.
authors.affiliation: Department of Anesthesiology, Kansai Medical University, Moriguchi.
authors.forename: Koh
authors.initials: K
authors.lastname: Shingu
authors.forename: Munehiro
authors.initials: M
authors.lastname: Masuzawa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Omote
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Namiki
authors.forename: Hirosato
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Miwako
authors.initials: M
authors.lastname: Kawamada
authors.forename: Shigehito
authors.initials: S
authors.lastname: Sato
authors.forename: Tomomasa
authors.initials: T
authors.lastname: Kimura
authors.forename: Norio
authors.initials: N
authors.lastname: Hatano
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakatsuka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Morita
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hara
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kanmura
authors.forename: Junzo
authors.initials: J
authors.lastname: Takeda
mesh_terms: D000732:Androstanols / Q000008:administration & dosage*; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D044466:Asian People; D005260:Female; D006801:Humans; D008297:Male; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D000077123:Rocuronium; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D000077123:Rocuronium