title: Cord blood dendritic cell subsets in African newborns exposed to Plasmodium falciparum in utero.
abstract: Placental Plasmodium falciparum infection affects birth outcomes and sensitizes fetal lymphocytes to parasite antigens. We assessed the influence of maternal P. falciparum infection on fetal myeloid dendritic cells (mDC) and plasmacytoid dendritic cells (pDC), analyzing the cord blood of offspring of Gabonese mothers with different infection histories. Cord blood from newborns of mothers with malarial infection at delivery had significantly more mDC than that from nonexposed newborns (P = 0.028) but mDC and pDC HLA-DR expression was unrelated to maternal infection history. Independently of these findings, cord blood mDC and pDC numbers declined significantly as a function of increasing maternal age (P = 0.029 and P = 0.033, respectively). The inducible antigen-specific interleukin-10-producing regulatory-type T-cell population that we have previously detected in cord blood of newborns with prolonged in utero exposure to P. falciparum may directly reflect the altered DC numbers in such neonates, while the maintenance of cord blood DC HLA-DR expression contrasts with that of DC from P. falciparum malaria patients.
authors.affiliation: Medical Parasitology-268, Department of Medical Microbiology, MMB-NCMLS, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Lutz P
authors.initials: LP
authors.lastname: Breitling
authors.forename: Rolf
authors.initials: R
authors.lastname: Fendel
authors.forename: Benjamin
authors.initials: B
authors.lastname: Mordmueller
authors.forename: Ayola A
authors.initials: AA
authors.lastname: Adegnika
authors.forename: Peter G
authors.initials: PG
authors.lastname: Kremsner
authors.forename: Adrian J F
authors.initials: AJ
authors.lastname: Luty
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000276:immunology* / Q000469:parasitology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D037181:Lectins, C-Type / Q000032:analysis; D016778:Malaria, Falciparum / Q000276:immunology / Q000635:transmission*; D008562:Membrane Glycoproteins / Q000032:analysis; D010963:Plasmodium falciparum; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology*; D011971:Receptors, Immunologic / Q000032:analysis; D014599:Uterus / Q000276:immunology / Q000469:parasitology
chemical_list: C443299:CLEC4C protein, human; D006684:HLA-DR Antigens; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic