title: Time-frequency analysis reveals decreased high-frequency oscillations in writer's cramp.
abstract: High-frequency oscillations (HFO) have been suggested to reflect the activity of thalamocortical and/or intracortical neurons bursting at high frequencies. These circuits seem to be involved in pathophysiological mechanisms of focal dystonia. In healthy subjects, we characterized the spectrotemporal properties of HFO patterns evoked by dominant-hand median-nerve stimulation, using magnetoencephalography coupled with time-frequency analysis. Then, we investigated HFO in patients with writer's cramp and found that HFO patterns are strongly decreased in power and disorganized in time. This supports the assumption that abnormal HFOs reflect pathophysiological mechanisms occurring in focal dystonia, possibly resulting from a dysfunction of somatosensory processing.
authors.affiliation: Pierre & Marie Curie University, Paris, France. cimatti@chups.jussieu.fr
authors.forename: Zoé
authors.initials: Z
authors.lastname: Cimatti
authors.forename: Denis P
authors.initials: DP
authors.lastname: Schwartz
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bourdain
authors.forename: Sabine
authors.initials: S
authors.lastname: Meunier
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bleton
authors.forename: Marie
authors.initials: M
authors.lastname: Vidailhet
authors.forename: Bernard
authors.initials: B
authors.lastname: Renault
authors.forename: Line
authors.initials: L
authors.lastname: Garnero
mesh_terms: D000328:Adult; D020821:Dystonic Disorders / Q000503:physiopathology*; D004558:Electric Stimulation / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D011930:Reaction Time; D013997:Time Factors