title: -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia.
abstract: OBJECTIVE
  To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma.
  
  
  METHODS
  A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method.
  
  
  RESULTS
  -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).
  
  
  CONCLUSIONS
  -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.
authors.affiliation: Serviço de Gastrenterologia, Instituto Português de Oncologia do Porto FG EPE, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal.
authors.forename: Carina
authors.initials: C
authors.lastname: Pereira
authors.forename: Hugo
authors.initials: H
authors.lastname: Sousa
authors.forename: Paula
authors.initials: P
authors.lastname: Ferreira
authors.forename: Maria
authors.initials: M
authors.lastname: Fragoso
authors.forename: Luís
authors.initials: L
authors.lastname: Moreira-Dias
authors.forename: Carlos
authors.initials: C
authors.lastname: Lopes
authors.forename: Rui
authors.initials: R
authors.lastname: Medeiros
authors.forename: Mário
authors.initials: M
authors.lastname: Dinis-Ribeiro
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000483:Alleles; D001284:Atrophy / Q000235:genetics / Q000473:pathology; D003430:Cross-Sectional Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D003553:Cystine / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006147:Guanine / Q000032:analysis; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008679:Metaplasia / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011174:Portugal; D012044:Regression Analysis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm; D008565:Membrane Proteins; D003553:Cystine; D006147:Guanine; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human