The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.
Electron paramagnetic resonance (EPR) spectroscopy was used to investigate the gamma-radiation damage in the crystalline powder form of nine calcium channel blockers from the 1,4-dihydropyridine derivatives, which are in clinical use for treatment of arteria hypertension and ischemic heart disease. EPR studies have been carried out, showing the influence of irradiation and storage parameters on the nature and concentration of the free radicals trapped. EPR spectra of isardipine and felodipine showed single EPR line. EPR spectra of nifedipine, nisoldipine, nitrendipine, nimodipine, nicardipine and nilvadipine reveal a broad anisotropic signal of hyperfine interaction. No EPR signal was observed from amlodipine.
Naskrent
Marek
M
Department of Medical Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland. marekn@amu.edu.pl
Mielcarek
Jadwiga
J
D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000627:therapeutic use; D004095:Dihydropyridines / Q000737:chemistry* / Q000528:radiation effects* / Q000627:therapeutic use; D004578:Electron Spin Resonance Spectroscopy; D015736:Felodipine / Q000737:chemistry; D005720:Gamma Rays; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008958:Models, Molecular; D008968:Molecular Conformation; D017202:Myocardial Ischemia / Q000188:drug therapy; D009543:Nifedipine / Q000031:analogs & derivatives; D009553:Nimodipine / Q000031:analogs & derivatives
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D009553:Nimodipine; C038806:1,4-dihydropyridine; D009543:Nifedipine; D015736:Felodipine