Synthesis and antibacterial activity of novel neamine derivatives.
Synthesis and activity of derivatives at the O5 or O6 positions of 1-N-((S)-4-amino-2-hydroxybutyryl)-3',4'-dideoxyneamine, which is the neamine moiety of arbekacin, were reported. Among these results, the 5-O-aminoethylaminocarbonyl derivative showed effective activity against Staphylococcus aureus expressing a bifunctional aminoglycoside-modifying enzyme AAC(6')-APH(2'').
Minowa
Nobuto
N
Pharmaceutical Research Department, Meiji Seika Kaisha, Ltd, 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. nobuto_minowa@meiji.co.jp
Akiyama
Yoshihisa
Y
Hiraiwa
Yukiko
Y
Maebashi
Kazunori
K
Usui
Takayuki
T
Ikeda
Daishiro
D
D000617:Aminoglycosides / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D005601:Framycetin / Q000138:chemical synthesis* / Q000494:pharmacology*; D016106:Methicillin Resistance; D008958:Models, Molecular; D008968:Molecular Conformation; D013211:Staphylococcus aureus / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005601:Framycetin; C488396:neamine