title: Effective protection against experimental Taenia solium tapeworm infection in hamsters by primo-infection and by vaccination with recombinant or synthetic heterologous antigens.
abstract: The disease caused by Taenia solium is progressively being recognized as a growing global threat for public human health and pig husbandry that requires the development of effective control measures. A central participant in the taeniasis/cysticercosis transmission network is the human carrier of the adult tapeworm because of its great potential in spreading the infection. Herein, evidence is presented that a primary infection of golden hamsters with orally administered T. solium cysticerci improved the host's resistance against a secondary infection. Likewise, previous vaccination increased the hamster's resistance. Similar high levels of protection (> 78%) were induced by systemic or oral vaccination with the S3Pvac anticysticercosis synthetic peptide vaccine or the highly immunogenic recombinant chimera based on the protective peptide KETc1 bound to Brucella spp. lumazine synthase (BLS-KETc1). Increased resistance after primo-infection and vaccination possibly results from changes in the immune conditions prevailing in the host's intestine. The contribution to protection from the KETc1 and BLS epitopes in a chimeric vaccine is under study. Preventive vaccination of definitive hosts of T. solium against the tapeworm, the most relevant step in the taeniasis/cysticercosis transmission, may greatly impact the dynamics of endemic disease and has not been studied or tried previously.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, México D.F. C.P. 04510, México.
authors.forename: C
authors.initials: C
authors.lastname: Cruz-Revilla
authors.forename: A
authors.initials: A
authors.lastname: Toledo
authors.forename: G
authors.initials: G
authors.lastname: Rosas
authors.forename: M
authors.initials: M
authors.lastname: Huerta
authors.forename: I
authors.initials: I
authors.lastname: Flores-Perez
authors.forename: N
authors.initials: N
authors.lastname: Peña
authors.forename: J
authors.initials: J
authors.lastname: Morales
authors.forename: J
authors.initials: J
authors.lastname: Cisneros-Quiñones
authors.forename: G
authors.initials: G
authors.lastname: Meneses
authors.forename: A
authors.initials: A
authors.lastname: Díaz-Orea
authors.forename: N
authors.initials: N
authors.lastname: Anciart
authors.forename: F
authors.initials: F
authors.lastname: Goldbaum
authors.forename: A
authors.initials: A
authors.lastname: Aluja
authors.forename: C
authors.initials: C
authors.lastname: Larralde
authors.forename: G
authors.initials: G
authors.lastname: Fragoso
authors.forename: E
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D007121:Immunocompetence; D008297:Male; D008647:Mesocricetus; D041201:Taenia solium / Q000276:immunology*; D013622:Taeniasis / Q000517:prevention & control*; D014611:Vaccination; D014614:Vaccines, Synthetic
chemical_list: D000947:Antigens, Helminth; D014614:Vaccines, Synthetic