title: Bilateral comparison of conventional versus topographic-guided customized ablation for myopic LASIK with the NIDEK EC-5000.
abstract: OBJECTIVE
  To compare visual acuity and higher order aberrations before and after myopic LASIK using conventional versus customized ablation.
  
  
  METHODS
  This prospective, randomized study included 54 myopic eyes in 27 patients who underwent bilateral LASIK using the NIDEK EC-5000 excimer laser system (NIDEK Technologies, Gamagori, Japan). Customized aspheric treatment zone (CATz) treatment was used in one eye (CATz group) and conventional ablation (conventional group) was used in the fellow eye. Uncorrected visual acuity (UCVA) and higher order aberrations (root-mean-square [RMS] in 4-mm and 6-mm zones) of both groups were observed with the NIDEK OPD-Scan aberrometer before and 3 months after LASIK. Preoperative mean refractive error was similar for both eyes of each patient (P>.05).
  
  
  RESULTS
  No statistically significant differences were noted in preoperative higher order aberrations (RMS in 4-mm and 6-mm zones) between groups (P>.05). No statistically significant difference was noted between pre- and postoperative higher order aberrations in the CATz group (P>.05). However, a highly statistically significant increase in higher order aberrations was observed after conventional ablation (P<.001). There was a statistically significant higher increase of higher order aberrations after LASIK in the conventional group than the CATz group (P<.05). Postoperative UCVA with both conventional and customized ablation was not significantly different (P>.05).
  
  
  CONCLUSIONS
  LASIK with conventional ablation and CATz ablation resulted in the same UCVA. The increase in higher order aberrations after CATz ablation was less than after conventional ablation.
authors.affiliation: ZheYi Eye Center, The First Affiliated Hospital, Medical School, Zhejiang University, 79 Qingchun Rd, Hangzhou, Zhejiang, China 310003. duchixin@126.com
authors.forename: Chi-xin
authors.initials: CX
authors.lastname: Du
authors.forename: Ya-bo
authors.initials: YB
authors.lastname: Yang
authors.forename: Ye
authors.initials: Y
authors.lastname: Shen
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dougherty
mesh_terms: D000293:Adolescent; D000328:Adult; D003319:Corneal Stroma / Q000601:surgery*; D019781:Corneal Topography; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D009216:Myopia / Q000601:surgery*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology