Nosocomial spread of OXA-58-positive carbapenem-resistant Acinetobacter baumannii isolates in a paediatric hospital in Greece.
Twelve non-repetitive Acinetobacter baumannii isolates producing the carbapenem-hydrolysing oxacillinase OXA-58 were recovered from patients in the same paediatric hospital in Athens, Greece, between November 2003 and May 2005. All isolates were clonally related, but the bla(OXA-58) gene was not always plasmid-located and there were variations in the DNA sequences surrounding the OXA-58 gene in different isolates. This study emphasises the importance of the bla(OXA-58) carbapenemase gene in conferring carbapenem resistance among A. baumannii isolates in Greece.
Poirel
L
L
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.
Lebessi
E
E
Héritier
C
C
Patsoura
A
A
Foustoukou
M
M
Nordmann
P
P
D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D015780:Carbapenems / Q000494:pharmacology*; D002648:Child; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D004351:Drug Resistance / Q000235:genetics*; D006115:Greece / Q000453:epidemiology; D006776:Hospitals, Pediatric; D006786:Hospitals, Urban; D006801:Humans; D012307:Risk Factors; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D015780:Carbapenems; D001618:beta-Lactamases