title: Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain manfredo.
abstract: Comparisons of the 1.84-Mb genome of serotype M5 Streptococcus pyogenes strain Manfredo with previously sequenced genomes emphasized the role of prophages in diversification of S. pyogenes and the close relationship between strain Manfredo and MGAS8232, another acute rheumatic fever-associated strain.
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK. mh3@sanger.ac.uk
authors.forename: Matthew T G
authors.initials: MT
authors.lastname: Holden
authors.forename: Annabel
authors.initials: A
authors.lastname: Scott
authors.forename: Inna
authors.initials: I
authors.lastname: Cherevach
authors.forename: Tracey
authors.initials: T
authors.lastname: Chillingworth
authors.forename: Carol
authors.initials: C
authors.lastname: Churcher
authors.forename: Ann
authors.initials: A
authors.lastname: Cronin
authors.forename: Linda
authors.initials: L
authors.lastname: Dowd
authors.forename: Theresa
authors.initials: T
authors.lastname: Feltwell
authors.forename: Nancy
authors.initials: N
authors.lastname: Hamlin
authors.forename: Simon
authors.initials: S
authors.lastname: Holroyd
authors.forename: Kay
authors.initials: K
authors.lastname: Jagels
authors.forename: Sharon
authors.initials: S
authors.lastname: Moule
authors.forename: Karen
authors.initials: K
authors.lastname: Mungall
authors.forename: Michael A
authors.initials: MA
authors.lastname: Quail
authors.forename: Claire
authors.initials: C
authors.lastname: Price
authors.forename: Ester
authors.initials: E
authors.lastname: Rabbinowitsch
authors.forename: Sarah
authors.initials: S
authors.lastname: Sharp
authors.forename: Jason
authors.initials: J
authors.lastname: Skelton
authors.forename: Sally
authors.initials: S
authors.lastname: Whitehead
authors.forename: Bart G
authors.initials: BG
authors.lastname: Barrell
authors.forename: Michael
authors.initials: M
authors.lastname: Kehoe
authors.forename: Julian
authors.initials: J
authors.lastname: Parkhill
mesh_terms: D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D014644:Genetic Variation; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D010802:Phylogeny; D012213:Rheumatic Fever / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000378:metabolism*