[Experimental study on a novel affinity adsorbent for removal of endotoxin in plasma].
In this paper, the adsorbent properties of Polymyxin B immobilized polystyrene microbeads to remove endotoxin from plasma were studied and the factors that affected the absorption of endotoxin were discussed. The rat models of endotoxemia were established, which were used in hemoperfusion. The experiment results indicated that the novel affinity adsorbent could remove endotoxin from plasma effectively. Moreover, the results also showed that Polymyxin B immobilized polystyrene microbeads was a fine biomaterial of hemoperfusion as well as exhibited a satisfactory blood compatibility.
Li
Yuan
Y
Key Lab for Biomechanical & Tissue Engineering under the State Ministry of Education, Chongqing University,Chongqing 400044, China.
Wang
Xiang
X
Xiong
Xingliang
X
ShaoYang
Gao
Wei
W
Cai
Shaoxi
S
D000327:Adsorption; D000818:Animals; D019446:Endotoxemia / Q000097:blood / Q000628:therapy; D004731:Endotoxins / Q000302:isolation & purification*; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D011112:Polymyxin B; D011137:Polystyrenes; D051381:Rats; D017208:Rats, Wistar
D004731:Endotoxins; D011137:Polystyrenes; D011112:Polymyxin B