Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link?
BACKGROUND
Acute pancreatitis has occasionally been reported in association with Campylobacter jejuni infection in humans. However, the mechanism linking Campylobacter jejuni infection and pancreatitis is unclear. Acute pancreatitis in association with an infectious illness may be related to underlying genetic mutations. For instance, studies show that mutations in the cystic fibrosis transmembrane conductance regulator gene increase the susceptibility for acute and chronic pancreatitis.


METHODS
We describe a patient with Campylobacter jejuni infection who developed acute pancreatitis in the setting of an underlying cystic fibrosis transmembrane conductance regulator gene mutation.


CONCLUSIONS
In this patient with an underlying mutation in the CFTR gene, we propose that the interaction between the mutant gene and an environmental factor, Campylobacter jejuni infection, resulted in pancreatitis.
Kandula
Leena
L
Department of Pediatrics, University of Pittsburgh, Children's Hospital of Pittsburgh, PA 15213, USA.
Khan
Seema
S
Whitcomb
David C
DC
Lowe
Mark E
ME
D000208:Acute Disease; D000293:Adolescent; D002169:Campylobacter Infections / Q000150:complications* / Q000235:genetics; D016123:Campylobacter jejuni; D003550:Cystic Fibrosis / Q000150:complications* / Q000235:genetics; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D003967:Diarrhea / Q000235:genetics / Q000382:microbiology; D005260:Female; D006801:Humans; D010195:Pancreatitis / Q000235:genetics / Q000382:microbiology*
C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator