title: Facile synthesis of substituted thiophenes via Pd/C-mediated sonogashira coupling in water.
abstract: The first successful Pd/C-mediated Sonogashira coupling of iodothiophene with terminal alkynes in water is described here. Pd/C-CuI-PPh(3) was found to be an efficient catalyst system for this coupling reaction. Using this economic and reliable process a variety of acetylenic thiophenes with a wide range of functional groups were prepared in good yields. Synthetic applications and in vitro anticancer properties of some of the compounds synthesized are described.
authors.affiliation: Custom Pharmaceutical Services, Bollaram Road, Miyapur, Hyderabad 500049, India.
authors.forename: Sirisilla
authors.initials: S
authors.lastname: Raju
authors.forename: P Rajender
authors.initials: PR
authors.lastname: Kumar
authors.forename: K
authors.initials: K
authors.lastname: Mukkanti
authors.forename: Pazhanimuthu
authors.initials: P
authors.lastname: Annamalai
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D002244:Carbon; D007202:Indicators and Reagents; D047028:Macrocyclic Compounds / Q000737:chemistry*; D010165:Palladium; D013876:Thiophenes / Q000138:chemical synthesis*; D014867:Water
chemical_list: D007202:Indicators and Reagents; D047028:Macrocyclic Compounds; D013876:Thiophenes; D014867:Water; D010165:Palladium; D002244:Carbon