title: Impaired inhibitory oculomotor control in patients with Parkinson's disease.
abstract: A hallmark of voluntary control is the capacity to inhibit or change partially prepared responses, an ability thought to be compromised in patients with Parkinson's disease (PD). To test this hypothesis in relation to oculomotor control, PD patients and age-matched controls performed a redirect task in which they were instructed to cancel a partially prepared saccade on some random fraction of trials. Using a race model framework, the time it takes to cancel a saccade, the target switch reaction time (TSRT), was estimated for PD and control subjects. While saccadic reaction times of control and PD subjects were similar, the average TSRT in PD subjects was 139 ms, and was significantly greater than the TSRT in controls, which was 113 ms. These results support the hypothesis that poor voluntary control exhibited by PD patients in a variety of complex behaviors may be caused by impaired inhibitory control as a result of basal ganglia dysfunction.
authors.affiliation: National Brain Research Centre, Nainwal More, Manesar, Haryana 122 050, India.
authors.forename: Prakash
authors.initials: P
authors.lastname: Joti
authors.forename: Shrikanth
authors.initials: S
authors.lastname: Kulashekhar
authors.forename: Madhuri
authors.initials: M
authors.lastname: Behari
authors.forename: Aditya
authors.initials: A
authors.lastname: Murthy
mesh_terms: D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology*; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D009801:Oculomotor Muscles / Q000294:innervation / Q000503:physiopathology; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology*; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D012438:Saccades / Q000502:physiology