title: Borrelia burgdorferi complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes is expressed in humans and induces antibody responses restricted to nondenatured structural determinants.
abstract: Borrelia burgdorferi complement regulator-acquiring surface protein 1 (CRASP-1), the dominant factor H and FHL-1-binding protein of the Lyme disease spirochete B. burgdorferi, is implicated in pathogen persistence and was recently reported to be nonimmunogenic in humans. Here we show that serum samples from Lyme disease patients contain antibodies with exclusive specificity for nondenatured structural determinants of CRASP-1.
authors.affiliation: Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Rossmann
authors.forename: Veronique
authors.initials: V
authors.lastname: Kitiratschky
authors.forename: Heidelore
authors.initials: H
authors.lastname: Hofmann
authors.forename: Peter
authors.initials: P
authors.lastname: Kraiczy
authors.forename: Markus M
authors.initials: MM
authors.lastname: Simon
authors.forename: Reinhard
authors.initials: R
authors.lastname: Wallich
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D000917:Antibody Formation; D001426:Bacterial Proteins / Q000276:immunology*; D025065:Borrelia burgdorferi / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008193:Lyme Disease / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D000939:Epitopes; D008565:Membrane Proteins; C440651:complement regulator-acquiring surface proteins, Borrelia burgdorferi