Nervous Rac: DOCK7 regulation of axon formation.
Microtubules play an important role in neuronal polarity. In this issue of Neuron, Watabe-Uchida et al. link a novel Rac-mediated pathway that regulates microtubule dynamics to axon formation.
Pinheiro
Elaine Maria
EM
Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA.
Gertler
Frank B
FB
D000818:Animals; D001369:Axons / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010766:Phosphorylation; D050777:Stathmin / Q000235:genetics / Q000378:metabolism*; D020744:rac GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*
C514577:DOCK7 protein, human; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D050777:Stathmin; D020744:rac GTP-Binding Proteins