title: The potential for sodium hexametaphosphate (SHMP) found in common children drinks to limit acid production in the oral biofilm.
abstract: OBJECTIVE
  Sodium hexametaphosphate (SHMP) is a widely used industrial preservative commonly found in children's drinks. In this paper we examined the effect of SHMP incorporated into children's drinks on acid production by the oral biofilm by monitoring salivary concentrations of lactic acid.
  
  
  METHODS
  Twelve healthy adult subjects with an average age 36 years (range 26-54 years) consumed 10 ml from four children's beverages (Coca Cola and three types of Sunny Delight supplemented with SHMP) and a standard solution of sucrose. Saliva was collected at intervals following exposure of the oral biofilm to the drinks and the clearance of carbohydrates and the appearance of lactate was measured using standard enzymatic techniques.
  
  
  RESULTS
  All the carbohydrates derived from the drinks were cleared from saliva within 15 min of consumption. Comparison of two drinks [Sunny D Normal and Sunny C] with the same carbohydrate, but different SHMP concentrations suggested that SHMP in these beverages had no significant effect on acid production.
  
  
  CONCLUSIONS
  In this clinical study the role of SHMP, incorporated in common beverages, did not inhibit acid production from carbohydrates.
authors.affiliation: Departments of Prosthodontics and Microbiology, King's College London Dental Institute at Guy's, King's and St. Thomas' Hospitals, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Murphy
authors.forename: D
authors.initials: D
authors.lastname: Beighton
authors.forename: D
authors.initials: D
authors.lastname: Clark
authors.forename: D
authors.initials: D
authors.lastname: Bartlett
mesh_terms: D000143:Acids / Q000378:metabolism; D000328:Adult; D001628:Beverages; D018441:Biofilms / Q000187:drug effects*; D002253:Carbonated Beverages; D004040:Dietary Carbohydrates / Q000378:metabolism; D019422:Dietary Sucrose / Q000378:metabolism; D005260:Female; D005520:Food Preservatives / Q000494:pharmacology*; D005632:Fructose / Q000032:analysis; D005947:Glucose / Q000032:analysis; D006801:Humans; D019344:Lactic Acid / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D010710:Phosphates / Q000494:pharmacology*; D012463:Saliva / Q000737:chemistry; D013395:Sucrose / Q000032:analysis; D013997:Time Factors
chemical_list: D000143:Acids; D004040:Dietary Carbohydrates; D019422:Dietary Sucrose; D005520:Food Preservatives; D010710:Phosphates; D005632:Fructose; D019344:Lactic Acid; D013395:Sucrose; D005947:Glucose; C009285:sodium polymetaphosphate