title: Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31-34.
abstract: We performed a whole genome microsatellite marker scan in six multiplex families with bipolar (BP) mood disorder ascertained in Antioquia, a historically isolated population from North West Colombia. These families were characterized clinically using the approach employed in independent ongoing studies of BP in the closely related population of the Central Valley of Costa Rica. The most consistent linkage results from parametric and non-parametric analyses of the Colombian scan involved markers on 5q31-33, a region implicated by the previous studies of BP in Costa Rica. Because of these concordant results, a follow-up study with additional markers was undertaken in an expanded set of Colombian and Costa Rican families; this provided a genome-wide significant evidence of linkage of BPI to a candidate region of approximately 10 cM in 5q31-33 (maximum non-parametric linkage score=4.395, P<0.00004). Interestingly, this region has been implicated in several previous genetic studies of schizophrenia and psychosis, including disease association with variants of the enthoprotin and gamma-aminobutyric acid receptor genes.
authors.affiliation: Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.
authors.forename: Ibi
authors.initials: I
authors.lastname: Herzberg
authors.forename: Anna
authors.initials: A
authors.lastname: Jasinska
authors.forename: Jenny
authors.initials: J
authors.lastname: García
authors.forename: Damini
authors.initials: D
authors.lastname: Jawaheer
authors.forename: Susan
authors.initials: S
authors.lastname: Service
authors.forename: Barbara
authors.initials: B
authors.lastname: Kremeyer
authors.forename: Constanza
authors.initials: C
authors.lastname: Duque
authors.forename: María V
authors.initials: MV
authors.lastname: Parra
authors.forename: Jorge
authors.initials: J
authors.lastname: Vega
authors.forename: Daniel
authors.initials: D
authors.lastname: Ortiz
authors.forename: Luis
authors.initials: L
authors.lastname: Carvajal
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Polanco
authors.forename: Gabriel J
authors.initials: GJ
authors.lastname: Restrepo
authors.forename: Carlos
authors.initials: C
authors.lastname: López
authors.forename: Carlos
authors.initials: C
authors.lastname: Palacio
authors.forename: Matthew
authors.initials: M
authors.lastname: Levinson
authors.forename: Ileana
authors.initials: I
authors.lastname: Aldana
authors.forename: Carol
authors.initials: C
authors.lastname: Mathews
authors.forename: Pablo
authors.initials: P
authors.lastname: Davanzo
authors.forename: Julio
authors.initials: J
authors.lastname: Molina
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fournier
authors.forename: Julio
authors.initials: J
authors.lastname: Bejarano
authors.forename: Magui
authors.initials: M
authors.lastname: Ramírez
authors.forename: Carmen Araya
authors.initials: CA
authors.lastname: Ortiz
authors.forename: Xinia
authors.initials: X
authors.lastname: Araya
authors.forename: Chiara
authors.initials: C
authors.lastname: Sabatti
authors.forename: Victor
authors.initials: V
authors.lastname: Reus
authors.forename: Gabriel
authors.initials: G
authors.lastname: Macaya
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bedoya
authors.forename: Jorge
authors.initials: J
authors.lastname: Ospina
authors.forename: Nelson
authors.initials: N
authors.lastname: Freimer
authors.forename: Andrés
authors.initials: A
authors.lastname: Ruiz-Linares
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D003105:Colombia; D003364:Costa Rica; D005260:Female; D018703:Founder Effect; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree; D018709:Statistics, Nonparametric