Concurrent carbogen and radiation therapy in children with high-risk brainstem gliomas.
In an attempt to improve local control, we assessed the feasibility of the addition of 4 min of carbogen inhalation (as a radiosensitizer) to daily fractionated radiotherapy in pediatric patients with high grade and/or diffuse brainstem gliomas. Ten patients inhaled carbogen for >90% of the radiation treatments. Median survival time from start of therapy was 0.80 years. Carbogen inhalation did not appear to improve the dismal prognosis.
Aquino-Parsons
C
C
Department of Radiation Oncology, Vancouver Cancer Center, BC Cancer Agency, Vancouver, British Columbia, Canada. cparsons@bccancer.bc.ca
Hukin
J
J
Green
A
A
D000280:Administration, Inhalation; D000293:Adolescent; D020295:Brain Stem Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D002245:Carbon Dioxide / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005910:Glioma / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D010100:Oxygen / Q000008:administration & dosage*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*
D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen