[Neuromuscular blocking effects of Org 9426 (rocuronium bromide); a comparative study with vecuronium bromide in Japanese patients].
BACKGROUND
Efficacy and safety of Org 9426 were compared with those of vecuronium bromide in Japanese patients.


METHODS
We studied 88 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of 0.6 mg x kg(-1), 0.9 mg x kg(-1) of Org 9426 or 0.1mg x kg(-1) of vecuronium. Following an intubation dose, patients received maintenance doses of 0.1, 0.15 or 0.2 mg x kg(-1) of Org 9426 or 0.025 mg x kg(-1) of vecuronium. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation.


RESULTS
The onset times of the 0.6 and 0.9 mg x kg(-1) of Org 9426 groups were 84.6 and 77.1 sec respectively, which showed statistical difference between the onset time of 0.1 mg x kg(-1) of vecuronium, 125.7 sec. The intubation condition was similar among three treatment groups. The clinical durations of 0.6 and 0.9 mg x kg(-1) of Org 9426 and 0.1 mg x kg(-1) of vecuronium were 53.4, 73.4 and 59.9 min, respectively. Clinical duration and spontaneous recovery time of maintenance dose of 0.15 mg x kg(-1) of Org 9426 were similar to those of 0.025 mg x kg(-1) of vecuronium.


CONCLUSIONS
Org 9426 showed more rapid onset time than that of vecuronium and similar clinical duration and recovery times to those of vecuronium in Japanese patients.
Shingu
Koh
K
Department of Anesthesiology, Kansai Medical University, Moriguchi.
Masuzawa
Munehiro
M
Omote
Keiichi
K
Namiki
Akiyoshi
A
Kikuchi
Hirosato
H
Kawamada
Miwako
M
Sato
Shigehito
S
Kimura
Tomomasa
T
Hatano
Norio
N
Nakatsuka
Hideki
H
Morita
Kiyoshi
K
Hara
Tetsuya
T
Kanmura
Yuichi
Y
Takeda
Junzo
J
D000732:Androstanols / Q000008:administration & dosage*; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D044466:Asian People; D005260:Female; D006801:Humans; D008297:Male; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D000077123:Rocuronium; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage*
D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D000077123:Rocuronium