title: Analysis of a partially observed binary covariate process and a censored failure time in the presence of truncation and competing risks.
abstract: We develop methods for assessing the association between a binary time-dependent covariate process and a failure time endpoint when the former is observed only at a single time point and the latter is right censored, and when the observations are subject to truncation and competing causes of failure. Using a proportional hazards model for the effect of the covariate process on the failure time of interest, we develop an approach utilizing EM algorithm and profile likelihood for estimating the relative risk parameter and cause-specific hazards for failure. The methods are extended to account for other covariates that can influence the time-dependent covariate process and cause-specific risks of failure. We illustrate the methods with data from a recent study on the association between loss of hepatitis B e antigen and the development of hepatocellular carcinoma in a population of chronic carriers of hepatitis B.
authors.affiliation: Department of Preventive Medicine, Northwestern University, 680 N. Lake Shore Drive, Suite 1102, Chicago, Illinois 60611, USA. lutian@northwestern.edu
authors.forename: Lu
authors.initials: L
authors.lastname: Tian
authors.forename: Stephen
authors.initials: S
authors.lastname: Lagakos
mesh_terms: D000465:Algorithms; D000704:Analysis of Variance; D001699:Biometry / Q000379:methods*; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D002353:Carrier State / Q000821:virology; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000150:complications / Q000821:virology; D006801:Humans; D016013:Likelihood Functions; D008113:Liver Neoplasms / Q000209:etiology; D015233:Models, Statistical; D016016:Proportional Hazards Models; D012306:Risk
chemical_list: D006513:Hepatitis B e Antigens