Leptin: a potential biomarker for childhood obesity?
Leptin, a hormone made by adipocytes, is an important circulating signal for the regulation of body weight. A review of the scientific literature (PubMed Search 1994 to 2005) for studies examining the relationship among leptin, pediatric obesity and the impact of exercise intervention programmes on leptin concentrations are summarized. The potential utility of leptin as a biomarker for identifying children at risk of obesity is discussed. This literature review demonstrated that (1) leptin directly interacts with the hypothalamus for energy balance regulation; (2) the measurement of free, bound and total leptin as well as soluble leptin receptor concentration are critical for our understanding of obesity in children; and (3) leptin concentration may be an important factor for determining intervention programme responsiveness in pediatric obesity.
Venner
Allison A
AA
Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. aavenner@ucalgary.ca <aavenner@ucalgary.ca>
Lyon
Martha E
ME
Doyle-Baker
Patricia K
PK
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D004435:Eating; D004734:Energy Metabolism; D015444:Exercise; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D020738:Leptin / Q000235:genetics / Q000378:metabolism*; D009765:Obesity / Q000209:etiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D054411:Receptors, Leptin; D012995:Solubility
D015415:Biomarkers; C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin