Influences along the path to maturity: regulation of cellular levels of RNA.
Initiation of RNA transcription may be a rate-limiting step in gene expression but it is only the first of many regulatory processes that impinge on nascent RNA along its path to maturity. Discontinuity between gene expression patterns within the nucleus and the cytoplasm suggests that multiple post-transcription regulatory points greatly influence the final RNA product, even to the extent of dramatically shifting the gene targets identified as a defined regulatory response.
Barton
Michelle Craig
MC
Department of Biochemistry and Molecular Biology, Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. mbarton@mdanderson.org
D015870:Gene Expression; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D014158:Transcription, Genetic
D012322:RNA Precursors; D012313:RNA