Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior.
Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines in the CA1 hippocampal pyramidal cells. Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior.
Nishijima
Ichiko
I
Center for Molecular and Human Genetics, Columbus Children's Research Institute, The Ohio State University, Columbus, OH 43205, USA. nishijii@pediatrics.ohio-state.edu
Yamagata
Takanori
T
Spencer
Corinne M
CM
Weeber
Edwin J
EJ
Alekseyenko
Olga
O
Sweatt
J David
JD
Momoi
Mariko Y
MY
Ito
Masayuki
M
Armstrong
Dawna L
DL
Nelson
David L
DL
Paylor
Richard
R
Bradley
Allan
A
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D003214:Conditioning, Classical; D049229:Dendritic Spines; D004594:Electrophysiology; D005239:Fear; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008568:Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D009048:Motor Skills; D009473:Neuronal Plasticity; D043562:Receptors, G-Protein-Coupled / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D011964:Receptors, Gastrointestinal Hormone / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D012633:Secretin / Q000502:physiology; D015398:Signal Transduction; D012919:Social Behavior
D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone; C029937:secretin receptor; D012633:Secretin