title: Genotoxic activity of halogenated phenylglycine derivatives.
abstract: The discovery of genotoxic amino acids derived from phenylglycine, and possessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.
authors.affiliation: Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez, 3, 38206-La Laguna, Tenerife, Spain. alicia@ipna.csic.es <alicia@ipna.csic.es>
authors.forename: Alicia
authors.initials: A
authors.lastname: Boto
authors.forename: Juan A
authors.initials: JA
authors.lastname: Gallardo
authors.forename: Rosendo
authors.initials: R
authors.lastname: Hernández
authors.forename: Francisco
authors.initials: F
authors.lastname: Ledo
authors.forename: Ana
authors.initials: A
authors.lastname: Muñoz
authors.forename: José R
authors.initials: JR
authors.lastname: Murguía
authors.forename: Mauricio
authors.initials: M
authors.lastname: Menacho-Márquez
authors.forename: Aurelio
authors.initials: A
authors.lastname: Orjales
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Saavedra
mesh_terms: D001550:Benzamidines / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D006219:Halogens / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D001550:Benzamidines; D006219:Halogens; C032157:benzamidine; D009584:Nitrogen; D010100:Oxygen; D005998:Glycine