Remodeling the plasticity debate: the presynaptic locus revisited.
The cellular mechanisms contributing to long-term potentiation and activity-induced formation of glutamatergic synapses have been intensely debated. Recent studies have sparked renewed interest in the role of presynaptic components in these processes. Based on the present evidence, it appears likely that long-term plasticity utilizes both pre- and postsynaptic expression mechanisms.
Krueger
Stefan
S
Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada. stefan.krueger@dal.ca
Fitzsimonds
Reiko Maki
RM
D000200:Action Potentials; D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism / Q000502:physiology; D006801:Humans; D009473:Neuronal Plasticity; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology; D017729:Presynaptic Terminals / Q000502:physiology*; D013569:Synapses / Q000502:physiology
D018377:Neurotransmitter Agents; D018698:Glutamic Acid