title: qnrA in CTX-M-producing Escherichia coli isolates from France.
abstract: By PCR, we screened for qnr genes 112 clinical isolates of extended-spectrum beta-lactamase-producing Escherichia coli collected from hospitals in France during 2004. For the first time, 7.7% of CTX-M-producing E. coli isolates presented a plasmid-mediated resistance to quinolones. All strains harbored a qnrA gene located on a sul1-type class 1 integron with similar structure to the In36 integron.
authors.affiliation: Laboratoire Universitaire d'Antibiologie, UFR de Médecine, Avenue Kennedy, 30908 Nîmes Cedex 02, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Lavigne
authors.forename: Hélène
authors.initials: H
authors.lastname: Marchandin
authors.forename: Julien
authors.initials: J
authors.lastname: Delmas
authors.forename: Nicole
authors.initials: N
authors.lastname: Bouziges
authors.forename: Evelyne
authors.initials: E
authors.lastname: Lecaillon
authors.forename: Laurent
authors.initials: L
authors.lastname: Cavalie
authors.forename: Hélène
authors.initials: H
authors.lastname: Jean-Pierre
authors.forename: Richard
authors.initials: R
authors.lastname: Bonnet
authors.forename: Albert
authors.initials: A
authors.lastname: Sotto
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification*; D005602:France; D005798:Genes, Bacterial; D032023:Integrons; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics; D016133:Polymerase Chain Reaction; D015363:Quinolones / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000890:Anti-Infective Agents; D015363:Quinolones; D009268:Nalidixic Acid; D001618:beta-Lactamases