title: Synergistic inhibition of microbial sulfide production by combinations of the metabolic inhibitor nitrite and biocides.
abstract: MICs of six broad-spectrum biocides and two specific metabolic inhibitors and fractional inhibitory concentration indexes (FICIs) for controlling a sulfide-producing consortium were determined. Nitrite was synergistic (FICI<1) with all but one biocide due to its specific inhibition of dissimilatory sulfite reductase. Hence, combining nitrite with biocides allows more efficient and cost-effective control of sulfate-reducing bacteria.
authors.affiliation: Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, Alberta T2N 1N4, Canada.
authors.forename: E Anne
authors.initials: EA
authors.lastname: Greene
authors.forename: Veronique
authors.initials: V
authors.lastname: Brunelle
authors.forename: Gary E
authors.initials: GE
authors.lastname: Jenneman
authors.forename: Gerrit
authors.initials: G
authors.lastname: Voordouw
mesh_terms: D001548:Benzalkonium Compounds / Q000494:pharmacology; D003901:Desulfovibrio / Q000187:drug effects* / Q000378:metabolism; D004202:Disinfectants / Q000494:pharmacology*; D004357:Drug Synergism; D005976:Glutaral / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009573:Nitrites / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology; D013440:Sulfides / Q000378:metabolism*; D016999:Sulfur-Reducing Bacteria / Q000187:drug effects* / Q000378:metabolism
chemical_list: D001548:Benzalkonium Compounds; D004202:Disinfectants; D009573:Nitrites; D011409:Propylene Glycols; D013440:Sulfides; C006827:bronopol; D005976:Glutaral