[Genomic and extragenomic mechanisms of antiglucocorticoid action of gestagens on thymocytes].
Effects of a new synthetic progesterone derivative 17a-acetoxy-3b-butanoyloxy-6-methyl-pregna-4,6-dien-20-one (ABMP) and the reference gestagen preparations on the rat thymus were evaluated by the degree of variation of the intracellular levels of calcium and cAMP, 3H-uridine inclusion into RNA, thymocyte viability, and thymus mass. It is shown that gestagens can produce antiglucocorticoid action on thymocytes, this activity being most pronounced in the case of ABMP.
Semeĭkin
A V
AV
Dukhanin
A S
AS
Samoĭlikov
R V
RV
Rzheznikov
V M
VM
Shimanovskiĭ
N L
NL
D019326:17-alpha-Hydroxyprogesterone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology*; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D011372:Progestins / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology; D014158:Transcription, Genetic
C498329:17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one; D000970:Antineoplastic Agents; D011372:Progestins; D011965:Receptors, Glucocorticoid; D019326:17-alpha-Hydroxyprogesterone; D003907:Dexamethasone; D000242:Cyclic AMP; D002118:Calcium