title: Bacterial meningitis associated with infliximab.
abstract: We report an episode of bacterial meningitis in a 45 year-old woman, who was treated with infliximab for Wegener's granulomatosis. This patient presented with the classic clinical presentation of acute meningitis: the triad of fever, neck stiffness, and an altered mental state that appeared 6 months after the infliximab initiation. A computed tomographic (CT) scan of the head showed cerebral edema and Streptococcus pneumoniae was isolated from blood and CSF cultures. Prompt diagnosis and early treatment improved the outcome of this patient.
authors.affiliation: Department of Internal Medicine F-Nahariya Hospital, B. Rappaport Faculty of Medicine, Western Galilee Hospital, 21, 22100 Technion, Nahariya, Israel. Raymond.Farah@naharia.health.gov.il
authors.forename: Raymond
authors.initials: R
authors.lastname: Farah
authors.forename: Svetlana
authors.initials: S
authors.lastname: Lisitsin
authors.forename: Moshe
authors.initials: M
authors.lastname: Shay
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000188:drug therapy; D006801:Humans; D000069285:Infliximab; D008586:Meningitis, Pneumococcal / Q000209:etiology* / Q000382:microbiology; D008875:Middle Aged; D013296:Streptococcus pneumoniae; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000069285:Infliximab