High plasma concentration of remnant lipoprotein cholesterol in obese children and adolescents.
OBJECTIVE
Remnant lipoproteins (RLPs) are the products of the lipolytic degradation of triglyceride-rich lipoproteins produced by the liver and intestine. Recent studies have demonstrated that RLPs are correlated with cardiovascular risk. We assessed the relationship between obesity and RLP and evaluated the factors related to RLP in children and adolescents.


METHODS
We measured BMI, waist circumference, blood pressure, body fat mass, total abdominal fat, visceral and subcutaneous fat areas, fasting glucose, insulin, total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, and RLP cholesterol in 135 children and adolescents (67 boys and 68 girls). Plasma RLP fractions were isolated using an immunoaffinity gel containing specific anti-apolipoprotein (apo) B-100 and anti-apoA-I antibodies. Based on the BMI percentile, the subjects were divided into two groups: normal (< 85th percentile) and overweight (> or = 85th percentile).


RESULTS
RLP cholesterol was significantly correlated with age, sex, BMI, waist circumference, systolic and diastolic blood pressures, visceral and subcutaneous fat areas, visceral-to-subcutaneous fat area ratio, total cholesterol, triglycerides, HDL cholesterol, apoB, and homeostasis model assessment of insulin resistance (HOMA-IR). According to the multivariate regression analysis, triglycerides (beta = 0.928, P < 0.001) were independently correlated with RLP cholesterol. After excluding lipid profiles as an independent variable, the multivariate regression analysis revealed that HOMA-IR (beta = 0.231, P = 0.007) and systolic blood pressure (beta = 0.169, P = 0.046) were independently associated with RLP cholesterol.


CONCLUSIONS
RLP cholesterol was significantly higher in obese children and adolescents. Triglycerides, systolic blood pressure, and insulin resistance were related to RLP cholesterol.
Choi
Yong Jun
YJ
Department of Endocrinology and Metabolism, Ajou University School of Medicine, San-5 Wonchon-Dong, Yongtong-Gu, Suwon 443-721, Republic of Korea.
Jo
Young Eun
YE
Kim
Yun Kyung
YK
Ahn
Sang Mi
SM
Jung
Sun Hye
SH
Kim
Hae Jin
HJ
Chung
Yoon-Sok
YS
Lee
Kwan Woo
KW
Kim
Dae Jung
DJ
D050153:Abdominal Fat / Q000033:anatomy & histology; D000293:Adolescent; D053299:Apolipoprotein B-100 / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002648:Child; D015243:Cholesterol, VLDL / Q000097:blood*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D050152:Intra-Abdominal Fat / Q000033:anatomy & histology; D007723:Korea; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D050151:Subcutaneous Fat / Q000033:anatomy & histology; D014280:Triglycerides / Q000097:blood
D053299:Apolipoprotein B-100; D015243:Cholesterol, VLDL; D014280:Triglycerides