Diabetic erectile dysfunction--an indicator of generalised endothelial function per se?
Erectile dysfunction (ED) affects up to 70% of men with diabetes. However, the pathophysiology of ED in diabetes remains uncertain with both neuronal and vascular factors cited. We examined whether ED is an indicator of generalized endothelial dysfunction. A unique group of diabetic patients free from established conventional cardiac risk factors were investigated. Forearm bloodflow responses to nitroprusside and acetylcholine on 11 diabetic men with ED and 11 potent diabetic men were measured by venous plethysmography. Patient characteristics between the impotent and potent patients were similar except for Hba1c which was higher in the group with ED (8.35% vs. 7.03%: p = 0.003). Both groups showed increases in FBF to incremental infusions of nitroprusside and acetylcholine but the area under curve (AUC) were similar in the ED and the non-ED groups (p = 0.16 and p = 0.17, respectively). We demonstrated that ED in patients with type 2 diabetes is not associated with additional generalized endothelial dysfunction.
Browne
D L
DL
Academic Department of Diabetes and Endocrinology, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, UK. duncan.browne@rcht.cornwall.nhs.uk
Meeking
D R
DR
Allard
S
S
Munday
L J
LJ
Shaw
K M
KM
Cummings
M H
MH
D019540:Area Under Curve; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005542:Forearm / Q000098:blood supply; D006801:Humans; D018783:Impotence, Vasculogenic / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000494:pharmacology
D009599:Nitroprusside