[Synthesis and characterizations of poly (ethylene glycol)-block-poly (glutamate)].
Amine-terminated poly (ethylene glycol) (PEG) was prepared by two steps. Firstly, potassium naphthalene was added to a solution of methoxypolyethylene glycol 5,000 in benzene until the solution maintains green in half of an hour, then excess tosylchloride was introduced; secondly, the conversion of the tosylate into an amine was carried out by Gabriel synthesis. The block copolymer poly (ethylene glycol)-co-poly (gamma-benzyl L-glutamate ) could be obtained by ring-opening polymerization of gamma-benzyl-L-glutamate N-carboxy anhydride with amine-terminated PEG as macroinitiator. And the benzyl group could be removed by sodium hydroxide. The product structure was characterized by IR, 1HNMR, GPC. The cisplatin-loaded micelle was observed by transmission electron microscope (TEM). And the block copolymer is expected to be useful as functional materials including carrier systems in drug controlled delivery applications.
Du
Jian
J
Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu 610041, China.
Zhang
Sheng
S
Zhang
Lifang
L
Sun
Rui
R
Xiong
Chengdong
C
Peng
Yuxing
Y
D004337:Drug Carriers; D011092:Polyethylene Glycols / Q000138:chemical synthesis; D011099:Polyglutamic Acid; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
D004337:Drug Carriers; D011108:Polymers; D011099:Polyglutamic Acid; D011092:Polyethylene Glycols