BOX elements modulate gene expression in Streptococcus pneumoniae: impact on the fine-tuning of competence development.
More than 100 BOX elements are randomly distributed in intergenic regions of the pneumococcal genome. Here we demonstrate that these elements can affect expression of neighboring genes and present evidence that they are mobile. Together, our findings show that BOX elements enhance genetic diversity and genomic plasticity in Streptococcus pneumoniae.
Knutsen
Eivind
E
Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway.
Johnsborg
Ola
O
Quentin
Yves
Y
Claverys
Jean-Pierre
JP
Håvarstein
Leiv Sigve
LS
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; C061262:ComA protein, Bacteria; C103179:ComE protein, Streptococcus pneumoniae; D004268:DNA-Binding Proteins