title: Effect of distal protection device on the microvascular integrity in acute myocardial infarction during primary percutaneous coronary intervention.
abstract: BACKGROUND
  The use of a distal protection device during primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) may preserve the microvascular integrity of the myocardium.
  
  
  RESULTS
  A total of 58 consecutive patients with AMI, who had undergone primary PCI within 24 h after onset, were enrolled (30 patients with the PercuSurge GuardWire System, 28 without). The coronary flow velocity reserve was not different between the 2 groups. In patients with a distal protection device, the post-PCI Thrombolysis In Myocardial Infarction myocardial perfusion grades (TMP) were more favorable (TMP 0/1: 13.3%, TMP 2: 23.3%, TMP 3: 63.4% vs TMP 0/1: 35.7%, TMP 2: 35.7%, TMP 3: 28.6%, p=0.023). These patients also exhibited lower basal and hyperemic microvascular resistance index levels (4.33+/-2.22 vs 5.55+/-2.36 mmHg . cm(-1) . s, p=0.047; 2.39+/-1.40 vs 3.14+/-1.36 mmHg . cm(-1) . s, p=0.045, respectively), and longer basal diastolic deceleration time (679+/-273 vs 519+/-289 ms, p=0.035) after PCI.
  
  
  CONCLUSIONS
  Distal protection with the PercuSurge GuardWire system may effectively preserve the microvascular integrity of the myocardium during primary PCI in AMI patients.
authors.affiliation: Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Myeong-Ho
authors.initials: MH
authors.lastname: Yoon
authors.forename: Seung-Jea
authors.initials: SJ
authors.lastname: Tahk
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Choi
authors.forename: Tae-Young
authors.initials: TY
authors.lastname: Choi
authors.forename: Byoung-Joo
authors.initials: BJ
authors.lastname: Choi
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Choi
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Yoo
authors.forename: Sung-Gyun
authors.initials: SG
authors.lastname: Ahn
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Zheng
authors.forename: Gyo-Seung
authors.initials: GS
authors.lastname: Hwang
authors.forename: Joon-Han
authors.initials: JH
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods*; D001783:Blood Flow Velocity; D003331:Coronary Vessels / Q000503:physiopathology*; D004864:Equipment and Supplies / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*