title: Preliminary human study for possible alteration of serum immunoglobulin E production in perennial allergic rhinitis with fermented milk prepared with Lactobacillus gasseri TMC0356.
abstract: The fermented milk prepared with Lactobacillus gasseri TMC0356 was administered at 200 ml per day for 4 weeks to 15 subjects with high serum IgE levels and perennial allergic rhinitis. The serum total IgE concentration was significantly reduced after 28 days' exposure to the fermented milk (P <0.05) compared to that before the intervention. The serum IgE specific to Acari and those to Japanese cedar pollen also significantly declined (P <0.05). T helper 1 (Th1) cells in the composition of their peripheral blood mononuclear cells (PBMCs) significantly increased after 14 days (P <0.01) and after 28 days (P <0.05). These results suggest that the fermented milk prepared with L. gasseri TMC0356 may alter serum IgE concentration, at least partly by enhancement of Th1 immune responses of the subjects with high concentration of serum IgE. However, further studies are still necessary to know the underlying mechanisms by which the tested fermented milk could influence the host immunity.
authors.affiliation: Technical Research Laboratory, Takanashi Milk Products Co., Ltd, Yokohama, Kanagawa, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Morita
authors.forename: Fang
authors.initials: F
authors.lastname: He
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawase
authors.forename: Akira
authors.initials: A
authors.lastname: Kubota
authors.forename: Masaru
authors.initials: M
authors.lastname: Hiramatsu
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kurisaki
authors.forename: Seppo
authors.initials: S
authors.lastname: Salminen
mesh_terms: D000293:Adolescent; D000328:Adult; D043302:Cultured Milk Products; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007155:Immunologic Factors / Q000494:pharmacology*; D007778:Lactobacillus / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000628:therapy; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D007155:Immunologic Factors; D007073:Immunoglobulin E