title: Cutaneous Langerhans cell histiocytosis with subsequent development of haematological malignancies. Report of two cases.
abstract: Adult cutaneous Langerhans cell histiocytosis (LCH) is a rare disease. We report two cases illustrating the variability of the clinical presentation and the response to treatment. In both cases a remission was achieved: in one case a partial remission with psoralen plus UVA irradiation (PUVA) and methotrexate plus topical corticosteroid ointment; in the other case by treatment with thalidomide. Despite a therapeutic response, both patients later developed haematological malignancies: a chronic myelo-monocytic leukaemia and an acute lymphatic leukaemia. In conclusion, patients with adult cutaneous LCH should be monitored carefully so that a secondary malignancy is not overlooked.
authors.affiliation: Department of dermatology Dresden, Friedrichstrasse 41, 01067 Dresden, Germany. wollinauw@khdf.de
authors.forename: U
authors.initials: U
authors.lastname: Wollina
authors.forename: M
authors.initials: M
authors.lastname: Kaatz
authors.forename: C
authors.initials: C
authors.lastname: Krönert
authors.forename: J
authors.initials: J
authors.lastname: Schönlebe
authors.forename: H
authors.initials: H
authors.lastname: Schmalenberg
authors.forename: G
authors.initials: G
authors.lastname: Schreiber
authors.forename: E
authors.initials: E
authors.lastname: Köstler
authors.forename: G
authors.initials: G
authors.lastname: Haroske
mesh_terms: D000328:Adult; D000368:Aged; D019337:Hematologic Neoplasms / Q000150:complications*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications*; D006801:Humans; D008297:Male