[Alcohol inhibited the expression of glial fibral acidic protein and S100 of astrocytes].
OBJECTIVE
To explore effects of alcohol on the expression of gial fibral acidic protein (GFAP) and S100 of astrocytes in brain.


METHODS
Different dosages of alcohol (2,5 and 20 mmol/L) were administered to astrocytes of fetal rat brain in vitro. The expression of GFAP and S100 of astrocytes was detected by immunocytochemistry, respectively.


RESULTS
With the dosage of alcohol increasing, the expression of GFAP and S100 was reduced and the number of astrocytes in high dosage group was observed to be decreased slightly.


CONCLUSIONS
It suggested that alcohol could repress the expression of GFAP and S100 of astrocytes, which might be the main mechanism of developmental abnormalities of central nervous system induced by alcohol.
Wang
Xia
X
Key Laboratory of Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.
Qu
Wei-dong
WD
Zhang
Tian-bao
TB
Wu
De-sheng
DS
D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005333:Fetus; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D009418:S100 Proteins / Q000378:metabolism*
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D000431:Ethanol