Helicobacter pylori infection and HFE hemochromatosis.
Helicobacter pylori infections are associated with iron deficiency, even in the absence of bleeding. To determine whether H. pylori infection plays a role in modifying the phenotype of patients homozygous for the c.845 G > A (C282Y) mutation of the HFE gene we studied 79 homozygous women and 76 homozygous men, comparing the pretreatment hemoglobin, MCV, serum ferritin, transferrin saturation of those who were seropositive and seronegative for H. pylori. No difference between seropositive and seronegative homozytoes was found. There was also no difference between seropositive and seronegative control subjects. We also compared the total iron of 56 of the male and 32 of the female homozygotes as determined by serial phlebotomy. No significant difference was found.
Beutler
Ernest
E
The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. beutler@scripps.edu
Gelbart
Terri
T
D005260:Female; D005293:Ferritins / Q000097:blood*; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications / Q000235:genetics; D006432:Hemochromatosis / Q000097:blood* / Q000150:complications / Q000235:genetics; D000071020:Hemochromatosis Protein; D006454:Hemoglobins / Q000032:analysis*; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D020125:Mutation, Missense; D014168:Transferrin / Q000032:analysis*
C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D006454:Hemoglobins; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D014168:Transferrin; D005293:Ferritins