title: Hepatic resection for colorectal metastasis: impact of tumour size.
abstract: BACKGROUND
  Many colorectal liver metastasis patients are denied surgical resection on the basis of tumour size. The aim of this study was to explore the impact of metastasis size on modern liver resection.
  
  
  METHODS
  Using a prospectively collected database, this was a retrospective analysis of 484 consecutive patients who underwent liver resection for colorectal liver metastases between 1993 and 2003. The cohort was divided into two groups: smaller metastases (< 8 cm) and larger metastases (> or = 8 cm). Those with larger metastases were then further stratified into big metastases (8-12 cm) and giant metastases (> 12 cm). Demographic, pathological, surgical technique and outcome data were compared between the groups.
  
  
  RESULTS
  There were 88 (18%) patients with metastases measuring 8 cm or larger. There was an association between higher carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9 levels and larger metastases. The actuarial 5-year survival for patients with larger metastases was 38% compared with 42% for smaller metastases (not statistically significant). Patients with giant metastases had poorer overall and disease-free survival (both nonsignificant) compared with those with big metastases: 29% and 28% at 5 years, respectively.
  
  
  CONCLUSIONS
  Patients with colorectal liver metastasis greater than 8 cm and up to 12 cm in size should not be treated differently from those with smaller lesions.
authors.affiliation: HPB and Transplant Unit, St. James's University Hospital, Leeds, LS9 7TF, UK.
authors.forename: Zaed Z R
authors.initials: ZZ
authors.lastname: Hamady
authors.forename: Hassan Z
authors.initials: HZ
authors.lastname: Malik
authors.forename: Robert
authors.initials: R
authors.lastname: Finch
authors.forename: Robert
authors.initials: R
authors.lastname: Adair
authors.forename: Ahmad
authors.initials: A
authors.lastname: Al-Mukhtar
authors.forename: K Rajendra
authors.initials: KR
authors.lastname: Prasad
authors.forename: Giles J
authors.initials: GJ
authors.lastname: Toogood
authors.forename: J Peter A
authors.initials: JP
authors.lastname: Lodge
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome