Transfer of accelerated presbycusis by transplantation of bone marrow cells from senescence-accelerated mice.
Until now, there has been no effective therapy for chronic sensorineural hearing impairment. This study investigated the role of bone marrow cells (BMCs) in cochlear dysfunction. BALB/c mice (2 months of age), a non-presbycusis-prone mouse strain, were lethally irradiated and then transplanted with BMCs from SAMP1 mice (2 months of age), a presbycusis-prone mouse strain. Acceleration of age-related hearing loss, early degeneration of spiral ganglion cells (SGCs) and impairment of immune function were observed in the recipient mice as well as in the SAMP1 mice. However, no spiral ganglion cells of donor (SAMP1) origin were detected in the recipient mice. These results indicated that accelerated presbycusis, cochlear pathology, and immune dysfunction of SAMP1 mice can be transferred to BALB/c recipient mice using allogeneic bone marrow transplantation (BMT). However, although the BMCs themselves cannot differentiate into the spiral ganglion cells (SGCs), they indirectly cause the degeneration of the SGCs. Further studies into the relationship between the inner ear cells and BMCs are required.
Baba
Susumu
S
Department of Otolaryngology, Kansai Medical University, 10-15 Fumizonocho, Moriguchi City, Osaka 570-8507, Japan.
Iwai
Hiroshi
H
Inaba
Muneo
M
Kawamoto
Kohei
K
Omae
Mariko
M
Yamashita
Toshio
T
Ikehara
Susumu
S
D000375:Aging / Q000235:genetics*; D000818:Animals; D041702:BALB 3T3 Cells; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods*; D002452:Cell Count; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005455:Fluorescent Antibody Technique / Q000379:methods; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009410:Nerve Degeneration / Q000235:genetics / Q000473:pathology; D011304:Presbycusis / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D011828:Radiation Chimera; D013136:Spiral Ganglion / Q000276:immunology / Q000473:pathology / Q000503:physiopathology