title: Chronic hypertension is an independent risk factor for preeclampsia and preterm delivery in women with rheumatologic diseases: a population-based study.
abstract: OBJECTIVE
  The objective was to determine the prevalence of maternal and perinatal complications among patients with rheumatologic diseases (RD) and to investigate the maternal risk factors for preeclampsia and preterm delivery among RD patients.
  
  
  METHODS
  A retrospective population-based cohort study was conducted. The study group comprised women with RD; the control group comprised patients without RD. The obstetric and neonatal outcomes of the groups were compared, and the data were obtained from a computerized database.
  
  
  RESULTS
  During the study period, there were 179 deliveries by 125 women with RD. The prevalence of severe preeclampsia, chronic hypertension, pregestational diabetes, oligohydramnios, preterm deliveries and cesarean sections was significantly higher in the RD group than in the control group. Mean birth weight was significantly lower in the study group compared with the general population. Maternal RD was found to be an independent risk factor for preterm delivery and severe preeclampsia (OR 3.59; 95% CI: 2.52-5.11; OR 3.05; 95% CI: 1.44-6.45, respectively). The presence of chronic hypertension in patients with RD was found to be an independent risk factor for severe preeclampsia and preterm delivery (OR 12.2; 95% CI: 2.1-69.8; OR 3.8; 95% CI: 1.1-12.7, respectively).
  
  
  CONCLUSIONS
  Chronic hypertension is an independent risk factor for preterm delivery and severe preeclampsia among RD patients.
authors.affiliation: Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of Negev, Beer-Sheva, Israel.
authors.forename: Amit
authors.initials: A
authors.lastname: Mayer
authors.forename: Offer
authors.initials: O
authors.lastname: Erez
authors.forename: Lena
authors.initials: L
authors.lastname: Novack
authors.forename: Asher
authors.initials: A
authors.lastname: Bashiri
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.forename: Moshe
authors.initials: M
authors.lastname: Mazor
mesh_terms: D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007231:Infant, Newborn; D011153:Population; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000150:complications*; D012307:Risk Factors