title: Highly efficient and reusable dendritic catalysts derived from N-prolylsulfonamide for the asymmetric direct aldol reaction in water.
abstract: The direct aldol reactions catalyzed by chiral dendritic catalysts derived from N-prolylsulfonamide gave the corresponding products in high isolated yields (up to 99%) with excellent anti diastereoselectivities (up to >99:1) and enantioselectivities (up to >99% ee) in water. In addition, catalyst 1e may be recovered by precipitation and filtration and reused for at least five times without loss of catalytic activity.
authors.affiliation: Anhui Key Laboratory of Functional Molecular Solids, Institute of Organic Chemistry, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Wu
authors.forename: Yazhu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Menglong
authors.initials: M
authors.lastname: Yu
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.forename: Shaowu
authors.initials: S
authors.lastname: Wang