The synaptic vesicle cycle: is kissing overrated?
In this issue of Neuron, Granseth et al. re-examine the mechanism of endocytosis at hippocampal synapses using a new optical reporter, sypHy. They conclude that only a single slow mode of endocytosis operates at this synapse and that retrieval after physiological stimuli is largely, if not solely, dominated by the clathrin-mediated pathway. These conclusions dispute previous assertions that "kiss-and-run" is a major mechanism of vesicle recycling at hippocampal synapses.
LoGiudice
Lisamarie
L
Graduate Program in Neuroscience, State University of New York, Stony Brook, New York 11794, USA.
Matthews
Gary
G
D000818:Animals; D002478:Cells, Cultured; D002966:Clathrin / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D008954:Models, Biological; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology*
D002966:Clathrin