Bacterial meningitis associated with infliximab.
We report an episode of bacterial meningitis in a 45 year-old woman, who was treated with infliximab for Wegener's granulomatosis. This patient presented with the classic clinical presentation of acute meningitis: the triad of fever, neck stiffness, and an altered mental state that appeared 6 months after the infliximab initiation. A computed tomographic (CT) scan of the head showed cerebral edema and Streptococcus pneumoniae was isolated from blood and CSF cultures. Prompt diagnosis and early treatment improved the outcome of this patient.
Farah
Raymond
R
Department of Internal Medicine F-Nahariya Hospital, B. Rappaport Faculty of Medicine, Western Galilee Hospital, 21, 22100 Technion, Nahariya, Israel. Raymond.Farah@naharia.health.gov.il
Lisitsin
Svetlana
S
Shay
Moshe
M
D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000188:drug therapy; D006801:Humans; D000069285:Infliximab; D008586:Meningitis, Pneumococcal / Q000209:etiology* / Q000382:microbiology; D008875:Middle Aged; D013296:Streptococcus pneumoniae; D014057:Tomography, X-Ray Computed
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000069285:Infliximab