Single trial-based prediction of a go/no-go decision in monkey superior colliculus.
While some decision-making processes often result in the generation of an observable action, for example eye or limb movements, others may prevent actions and occur without an overt behavioral response. To understand how these decisions are made, one must look directly at their neuronal substrates. We trained two monkeys on a go/no-go task which requires a saccade to a peripheral cue stimulus (go) or maintenance of fixation (no-go). We performed binary regressions on the activity of single neurons in the superior colliculus (SC), with the go/no-go decision as a predictor variable, and constructed a virtual decision function (VDF) designed to provide a good estimation of decision content and its timing in a single trial decision process. Post hoc analyses by VDF correctly predicted the monkey's choice in more than 80% of trials. These results suggest that monitoring of SC activity has sufficient capacity to predict go/no-go decisions on a trial-by-trial basis.
Hasegawa
Ryohei P
RP
Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan. r-hasegawa@aist.go.jp
Hasegawa
Yukako T
YT
Segraves
Mark A
MA
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal; D002755:Choice Behavior / Q000502:physiology*; D003463:Cues; D005260:Female; D008253:Macaca mulatta; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D012044:Regression Analysis; D012438:Saccades / Q000502:physiology; D013477:Superior Colliculi / Q000166:cytology*; D014794:Visual Fields / Q000502:physiology