Molecular genetic analyses of human endogenous retroviral elements belonging to the HERV-P family in primates, human tissues, and cancer cells.
Human endogenous retroviral sequences family P (HERV-P) proviral sequences have been located within the human genome. Here, we identify and analyze novel putative structural genes of HERV-P in primates, human tissues, and cancer cells with an aim toward better understanding their evolutionary relationships and transcriptional potential. The expression pattern of HERV-P structural genes indicates that they are actively amplified in human tissues and widely expressed in cancer cells, suggesting a potential role in carcinogenesis. Phylogenetic analyses suggest that the HERV-P family may be divided into two distinct categories that arose during primate evolution via active gene duplication. Taken together, our data provide a better understanding of the dynamic evolutionary features and potential functional roles of the HERV-P gene family.
Yi
Joo-Mi
JM
Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA.
Schuebel
Kornel
K
Kim
Heui-Soo
HS
D000818:Animals; D001483:Base Sequence; D045744:Cell Line, Tumor; D003001:Cloning, Molecular; D017931:DNA Primers / Q000235:genetics; D020077:Endogenous Retroviruses / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D005814:Genes, Viral; D006801:Humans; D008967:Molecular Biology; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics* / Q000821:virology*; D010802:Phylogeny; D011323:Primates / Q000235:genetics* / Q000821:virology*; D017422:Sequence Analysis, DNA
D017931:DNA Primers