N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema.
Administration of the VEGF receptor blocker SU5416 to rats causes alveolar septal cell apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic. Here we show that SU5416 induces the expression of heme oxygenase-1 in the lung tissue and that administration of antioxidant N-acetyl-l-cysteine protects alveolar septal cells against apoptosis, as demonstrated by caspase-3 lung immunohistochemistry, and against emphysema.
Demura
Yoshiki
Y
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave., C272, Denver, Colorado 80262, USA.
Taraseviciene-Stewart
Laima
L
Scerbavicius
Robertas
R
Tuder
Rubin M
RM
Voelkel
Norbert F
NF
D000111:Acetylcysteine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004646:Emphysema / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D017380:Hypertrophy, Right Ventricular / Q000517:prevention & control; D007211:Indoles / Q000494:pharmacology; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors*
D007211:Indoles; D011758:Pyrroles; C116890:Semaxinib; D051547:Heme Oxygenase-1; D040262:Receptors, Vascular Endothelial Growth Factor; D000111:Acetylcysteine