title: Principles and design of a novel magnetic force mechanical conditioning bioreactor for tissue engineering, stem cell conditioning, and dynamic in vitro screening.
abstract: Mechanical conditioning of cells and tissue constructs in bioreactors is an important factor in determining the properties of tissue being produced. Mechanical conditioning within a bioreactor environment, however, has proven difficult. This paper presents the theoretical basis, design, and initial results of a mechanical conditioning system for cell and tissue culture which is based on biocompatible magnetic micro- and nanoparticles acting as a remote stress mechanism without invasion of the sterile bioreactor environment.
authors.affiliation: Institute of Science and Technology in Medicine, Keele University, Stoke-on-Trent ST4 7QB, UK. j.p.dobson@keele.ac.uk
authors.forename: Jon
authors.initials: J
authors.lastname: Dobson
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Cartmell
authors.forename: Ahmed
authors.initials: A
authors.lastname: Keramane
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: El Haj
mesh_terms: D019149:Bioreactors; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008280:Magnetics / Q000295:instrumentation*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D049329:Nanostructures; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D010812:Physical Stimulation / Q000295:instrumentation* / Q000379:methods; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods