title: Left and right ventricular function is impaired in Behçet's disease.
abstract: OBJECTIVE
  Subclinical cardiac involvement may occur in patients with Behçet's disease (BD). The purpose of our study was to assess the noninvasive parameters of biventricular function derived from Doppler tissue imaging (DTI) of the tricuspid and mitral annular motion in BD.
  
  
  METHODS
  Twenty-one patients with BD and 20 control subjects were enrolled in this study. All subjects were selected to exclude those with cardiovascular risk factors. Standard echocardiography and pulsed DTI were obtained in every patient.
  
  
  RESULTS
  Peak systolic (13.71 +/- 2.09 vs 20.01 +/- 1.57, P < 0.001), peak early diastolic (11.26 +/- 2.52 vs 15.35 +/- 2.06, P < 0.001) tricuspid annular velocities were significantly lower in patients than controls. Peak systolic (8.68 +/- 1.4 vs 12.25 +/- 1.7, P < 0.001), peak early diastolic (7.89 +/- 1.07 vs 9.94 +/- 1.12, P < 0.001), and peak end diastolic (8.30 +/- 1.32 vs 9.23 +/- 0.91, P = 0.013) lateral mitral annular velocities were significantly lower in patients than controls.
  
  
  CONCLUSIONS
  We demonstrated that myocardial velocities, were affected in patients with BD. Therefore, we conclude that right and left ventricular function is impaired in patients with BD.
authors.affiliation: Faculty of Medicine, Department of Cardiology, Hacettepe University, Cinnah caddesi No. 11/6, Ankara, Turkey. byavuz.md@yahoo.com
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Yavuz
authors.forename: Levent
authors.initials: L
authors.lastname: Sahiner
authors.forename: Ali
authors.initials: A
authors.lastname: Akdogan
authors.forename: Gulcan
authors.initials: G
authors.lastname: Abali
authors.forename: Kudret
authors.initials: K
authors.lastname: Aytemir
authors.forename: Lale
authors.initials: L
authors.lastname: Tokgozoglu
authors.forename: Umut
authors.initials: U
authors.lastname: Kalyoncu
authors.forename: Omer
authors.initials: O
authors.lastname: Karadag
authors.forename: Sedat
authors.initials: S
authors.lastname: Kiraz
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ertenli
authors.forename: Meral
authors.initials: M
authors.lastname: Calguneri
authors.forename: Nasih
authors.initials: N
authors.lastname: Nazli
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001528:Behcet Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D009200:Myocardial Contraction; D012107:Research Design; D013318:Stroke Volume; D014261:Tricuspid Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D014421:Turkey; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right