title: [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin].
abstract: Mucinous metaplasia rarely develops in the non-neoplastic skin or its appendages, and almost exclusively confined to the genitalia, palms and soles. Similarly, mucinous metaplasia is quite uncommon in the cutaneous neoplasms and only few cases of clear cell hidradenomas and squamous cell carcinomas with mucinous metaplasia have been reported in the literature. Here we report a new case of clear cell hidradenoma with mucinous metaplasia in the forehead. Our immunohistochemical analysis revealed MUC5AC in the mucinous metaplastic cells of this tumor as in the extramammary Paget's disease, and expression of this gastric foveolar epithelial mucin core protein in these two neoplastic conditions seem to related to their common apocrine origin.
authors.affiliation: Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Ishida
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Kojima
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
authors.forename: Aki
authors.initials: A
authors.lastname: Kakutani
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Okabe
mesh_terms: D006607:Adenoma, Sweat Gland / Q000378:metabolism* / Q000473:pathology*; D005546:Forehead; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D055271:Mucin 5AC; D009077:Mucins / Q000032:analysis*; D013544:Sweat Gland Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: C524678:MUC5AC protein, human; D055271:Mucin 5AC; D009077:Mucins