title: Mucin overproduction in chronic inflammatory lung disease.
abstract: Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.
authors.affiliation: McGill University, Montreal, Quebec.
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hauber
authors.forename: Susan C
authors.initials: SC
authors.lastname: Foley
authors.forename: Qutayba
authors.initials: Q
authors.lastname: Hamid
mesh_terms: D002908:Chronic Disease; D016207:Cytokines / Q000502:physiology; D006801:Humans; D019272:Leukocyte Elastase / Q000502:physiology; D008173:Lung Diseases, Obstructive / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology; D009077:Mucins / Q000235:genetics / Q000378:metabolism*; D009093:Mucus / Q000378:metabolism
chemical_list: D016207:Cytokines; D009077:Mucins; D019272:Leukocyte Elastase