[Effect of afobazole on the accumulation of free radical oxidation products and the catalase activity in rats with cerebral ischemia].
The influence of afobazole on the accumulation of free radical oxidation products (reactive oxygen species, ROS) and on the activity of antioxidative enzyme catalase was studied in striatum and cortex of rats under cerebral ischemia damage conditions. Afobazole showed a tendency to decrease the extent of ROS accumulation in the cortex. In striatum, the intensity of ROS accumulation in rats after ischemia wasa reliably lower as compared to that in control rats, but afobazole produced a partial recovery of this parameter. Afobazole induced an increase in the catalase activity in the cortex of rats with ischemia. In contrast, afobazole did not change the activity of this enzyme in striatum (where it was also decreased by ischemia). Thus, afobazole increased the resistance of neuron membrane structures to free radical oxidation in cortex and striatum and stimulated the catalase activity in the cortex in rats with global reversible cerebral ischernia.
Silkina
I V
IV
Zenina
T A
TA
Seredenin
S B
SB
Mirzoian
R S
RS
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004789:Enzyme Activation; D009025:Morpholines / Q000494:pharmacology / Q000627:therapeutic use*; D017072:Neostriatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D002374:Catalase