title: The ARP2/3 complex: an actin nucleator comes of age.
abstract: The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
authors.forename: Erin D
authors.initials: ED
authors.lastname: Goley
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Welch
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000199:Actins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins