title: Cathepsin K expression is diminished in infants with bronchopulmonary dysplasia.
abstract: The expression of a potent collagenolytic enzyme, cathepsin K, was measured in repeated tracheal aspirate samples from premature infants with and without a chronic lung disorder, bronchopulmonary dysplasia (BPD). At 9--13 d, but not before, cathepsin K expression was significantly lower in the lungs of premature infants developing BPD.
  
  
  CONCLUSIONS
  Insufficient pulmonary cathepsin K in BPD may predispose premature lungs to pulmonary fibrosis.
authors.affiliation: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FIN-20520 Turku, Finland. jonni.knaapi@utu.fi
authors.forename: Jonni
authors.initials: J
authors.lastname: Knaapi
authors.forename: Heikki
authors.initials: H
authors.lastname: Lukkarinen
authors.forename: Riku
authors.initials: R
authors.lastname: Kiviranta
authors.forename: Aida
authors.initials: A
authors.lastname: Steiner
authors.forename: Patrick
authors.initials: P
authors.lastname: Lassus
authors.forename: Sture
authors.initials: S
authors.lastname: Andersson
authors.forename: Pekka
authors.initials: P
authors.lastname: Kääpä
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001997:Bronchopulmonary Dysplasia / Q000378:metabolism*; D056657:Cathepsin K; D002403:Cathepsins / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D051381:Rats
chemical_list: D002403:Cathepsins; C534130:CTSK protein, human; D056657:Cathepsin K; C534133:Ctsk protein, rat