title: Peripheral skin necrosis in the recipient of monochorionic twins complicated by twin-twin transfusion syndrome.
abstract: Twin-twin transfusion syndrome (TTTS) complicates approximately 15% of monochorionic, diamniotic twin pregnancies and if untreated carries a high perinatal loss rate of between 80% and 100%, depending on the stage. The underlying pathology in TTTS appears to be an imbalanced intertwin perfusion difference, secondary to functional unidirectional arteriovenous anastomoses within a monochorionic placenta. We report two cases of monochorionic twin pregnancy complicated by TTTS, in which the pregnancies were treated by serial aggressive amnioreduction. However, the recipient twin in each pregnancy developed 'ischemic damage' to a lower limb.
authors.affiliation: Department of Fetal Medicine, Division of Reproductive & Child Health, Birmingham Women's Hospital, Edgbaston, Birmingham, UK.
authors.forename: C
authors.initials: C
authors.lastname: Fox
authors.forename: P
authors.initials: P
authors.lastname: Cox
authors.forename: M D
authors.initials: MD
authors.lastname: Kilby
mesh_terms: D000328:Adult; D000649:Amniocentesis; D004200:Diseases in Twins / Q000196:embryology*; D005260:Female; D005330:Fetofetal Transfusion / Q000150:complications / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D007868:Leg Dermatoses / Q000196:embryology*; D009336:Necrosis / Q000196:embryology; D011247:Pregnancy; D012867:Skin / Q000473:pathology*