title: Hydroxylated gedunin derivatives from Cedrela sinensis.
abstract: Four new limonoids, 11alpha-hydroxygedunin (1), 11beta-hydroxygedunin (2), 7-deacetoxy-7alpha,11alpha-dihydroxygedunin (3), and 7-deacetoxy-7alpha,11beta-dihydroxygedunin (4), were isolated from the cortex of Cedrela sinensis, together with three known compounds, gedunin (5), 7-deacetoxy-7alpha-hydroxygedunin (6), and 11-oxogedunin (7). The structures of 1-4 were determined by a combination of 2D NMR experiments and chemical methods and by X-ray crystallography of 1 and 2.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Mitsui
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Saito
authors.forename: Ryota
authors.initials: R
authors.lastname: Yamamura
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fukaya
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hitotsuyanagi
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeya
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031587:Cedrela / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D036701:Limonins; C106014:gedunin