Effect of AC II, a herbal formulation on radiation-induced immunosuppression in mice.
A single dose of 6 Gy irradiation significantly reduced the total WBC count while in herbal formulation (AC II) treated groups it was found to be significantly increased. Similarly bone marrow cellularity and alpha-esterase positive cells, which were lowered by radiation, were partly restored in AC II treated groups. The data indicate that AC II can overcome the immunosuppression produced by irradiation.
Tharakan
Sheeja T
ST
Amala Ayurvedic Hospital, Amala Nagar, Thrissur, India.
Kuttan
Girija
G
Kuttan
Ramadasan
R
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D004950:Esterases / Q000378:metabolism; D005720:Gamma Rays; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance / Q000187:drug effects / Q000528:radiation effects; D008515:Medicine, Ayurvedic; D051379:Mice; D008807:Mice, Inbred BALB C; D028321:Plant Preparations / Q000008:administration & dosage / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects
C514509:AC II herbal formulation; D000276:Adjuvants, Immunologic; D028321:Plant Preparations; D004950:Esterases