title: Multiple memory mechanisms in the cerebellum?
abstract: Long-term potentiation (LTP) and long-term depression (LTD) are arguably two of the most widely discussed cellular plasticity mechanisms for learning and memory. However, the extent to which they are required for behavioral plasticity and learning is not clear. In this issue of Neuron, Boyden et al. use mice lacking CaMKIV and Hansel et al. use mice lacking alphaCaMKII to assess the contribution of LTD to cerebellar learning.
authors.affiliation: Neuroscience Program, University of Southern California, Los Angeles, 90089, USA.
authors.forename: Ka Hung
authors.initials: KH
authors.lastname: Lee
authors.forename: Richard F
authors.initials: RF
authors.lastname: Thompson
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002531:Cerebellum / Q000737:chemistry / Q000502:physiology*; D007858:Learning / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology*
chemical_list: D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C517685:Camk4 protein, mouse