Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity.
This study examined the density of dopamine transporter (DAT) and D2 receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D2 receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice.
Huang
Xu-Feng
XF
Department of Biomedical Science, University of Wollongong, NSW 2522, Australia.
Zavitsanou
Katerina
K
Huang
Xin
X
Yu
Yinghua
Y
Wang
HongQin
H
Chen
Feng
F
Lawrence
Andrew J
AJ
Deng
Chao
C
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004041:Dietary Fats; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017072:Neostriatum / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D011897:Random Allocation; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D018709:Statistics, Nonparametric
D004041:Dietary Fats; D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2