title: Leptin in energy balance and reward: two faces of the same coin?
abstract: Leptin receptors are expressed on mesolimbic dopamine neurons, yet little is known about the functional significance of this anatomical relationship. In this issue of Neuron, Hommel et al. reveal a novel site for leptin's regulation of feeding. In turn, Fulton et al. propose a novel role for leptin in regulating non-feeding-related motivated behaviors.
authors.affiliation: Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Ohio 45237, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Cota
authors.forename: Jason G
authors.initials: JG
authors.lastname: Barrera
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Seeley
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D020738:Leptin / Q000494:pharmacology*; D008636:Mesencephalon / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology*; D054411:Receptors, Leptin; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D017557:Ventral Tegmental Area / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D050796:STAT3 Transcription Factor; C515447:leptin receptor, mouse; D004298:Dopamine