title: Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro.
abstract: Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)- N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.
authors.affiliation: Department of Food Science & Technology, Tajen Institute of Technology, Ping Tung Hsien, Taiwan.
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Chia
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Che-Ming
authors.initials: CM
authors.lastname: Teng
authors.forename: Keh-Shaw
authors.initials: KS
authors.lastname: Chen
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D002478:Cells, Cultured; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010944:Plants / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D000470:Alkaloids; D007546:Isoquinolines; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors