title: Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone regeneration in a patient with compartment syndrome.
abstract: A 28-year-old man developed compartment syndrome in the right lower leg after fracture of the tibia and fibula. Despite fasciotomy, many arteries collapsed and union of the tibial and fibula fractures did not occur. Autologous bone marrow mononuclear cell (BMMNC) implantation for therapeutic angiogenesis and subsequent bone regeneration was performed and 4 weeks later, angiography showed a marked increase in collateral vessels surrounding the tibial fracture, and union was completed 6 months later. BMMNC implantation therapy might provide therapeutic angiogenesis and osteogensis in patients with compartment syndrome.
authors.affiliation: Department of Cardiovascular Physiology, Hiroshima University Graduate School of Biomedical Sciences, Kasumi, Hiroshima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Umemura
authors.forename: Kenji
authors.initials: K
authors.lastname: Nishioka
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kato
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
authors.forename: Masao
authors.initials: M
authors.lastname: Yoshizumi
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Higashi
mesh_terms: D016026:Bone Marrow Transplantation; D001861:Bone Regeneration; D003097:Collateral Circulation; D003161:Compartment Syndromes / Q000628:therapy*; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D007866:Leg; D008297:Male; D018919:Neovascularization, Physiologic; D014182:Transplantation, Autologous