title: Automatic lateralization of temporal lobe epilepsy based on scalp EEG.
abstract: OBJECTIVE
  The objective of this work is the determination of the lateralization of the epileptic seizure onset zone using the scalp EEG signal processing.
  
  
  METHODS
  A comprehensive method based on the evaluation of the evolution of the correlation coefficients computed between bipolar channels (longitudinal montage) was applied to 43 patients (87 seizures). The correlation coefficients are estimated by a nonlinear regression analysis. The methodology that leads to the lateralization is based on several processing steps: segmentation, seizure onset determination and then lateralization.
  
  
  RESULTS
  Results show that the mean level of the nonlinear correlation values computed between EEG channels at the seizure onset time is significantly higher on the side of the beginning of a seizure.
  
  
  CONCLUSIONS
  The side of the seizure onset was determined for about 80-90% of the seizures studied with a satisfactory high reproducibility level.
  
  
  CONCLUSIONS
  Comparison of nonlinear correlation coefficients between both sides of the brain leads to the determination of the side of seizure onset.
authors.affiliation: Centre de Recherche en Automatique de Nancy (CRAN - UMR 7039), Nancy-University, CNRS, ENSEM, 2 Avenue de la Forêt de Haye, Nancy, France. matthieu.caparos@ensem.inpl-nancy.fr
authors.forename: M
authors.initials: M
authors.lastname: Caparos
authors.forename: V
authors.initials: V
authors.lastname: Louis-Dorr
authors.forename: F
authors.initials: F
authors.lastname: Wendling
authors.forename: L
authors.initials: L
authors.lastname: Maillard
authors.forename: D
authors.initials: D
authors.lastname: Wolf
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D003625:Data Collection; D003627:Data Interpretation, Statistical; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon