APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians.
The cytosine deaminase APOBEC3G has been identified as a host factor that inhibits HIV-1 replication. We investigated whether genetic variants of APOBEC3G that could potentially affect the protein's expression or function were associated with the risk of infection in 122 Caucasians highly exposed to HIV-1. A novel C40693T variant was significantly associated with an increased risk of infection, suggesting that there might be a role for APOBEC3G in susceptibility to HIV-1 infection that warrants further investigation.
Valcke
Han Sang
HS
Laboratoire d'immunogénétique, Centre de Recherche du Centre Hospitalier, Université de Montréal, Montreal, Canada.
Bernard
Nicole F
NF
Bruneau
Julie
J
Alary
Michel
M
Tsoukas
Christos M
CM
Roger
Michel
M
D000071480:APOBEC-3G Deaminase; D003564:Cytidine Deaminase; D004198:Disease Susceptibility; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics / Q000635:transmission*; D018023:HIV Seronegativity; D015497:HIV-1; D006801:Humans; D007438:Introns; D009154:Mutation; D009700:Nucleoside Deaminases / Q000235:genetics*; D011446:Prospective Studies; D012097:Repressor Proteins / Q000235:genetics*; D012309:Risk-Taking; D014779:Virus Replication; D044465:White People
D012097:Repressor Proteins; D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase