title: [Dermatosis-arthritis syndrome associated with Crohn's disease in a teenager].
abstract: BACKGROUND
  Pustulosis, erythema nodosum, arthritis and systemic manifestations are associated in the dermatosis-arthritis syndrome. It is a well recognized complication of the bowel ileo-jejunal bypass but it is also associated with inflammatory bowel diseases.
  
  
  METHODS
  We report the case of an adolescent who presented with a dermatosis-arthritis syndrome associated to a Crohn's disease during a referring for pustulosis, erythema nodosum and fever. The evolution is complicated by proctorragia. Colonoscopy and intestinal biopsy found a Crohn's disease. Cutaneous and intestinal symptoms quickly improved with systemic corticosteroids.
  
  
  CONCLUSIONS
  The dermatosis-arthritis syndrome can be associated with bowel bypass and with inflammatory bowel disease, more frequently with ulcerative colitis than with Crohn's disease. It consists in a vesiculo-pustular eruption, erythema nodosum, fever, arthritis and ocular manifestations. Histopathology bears a strong resemblance with Sweet's syndrome. Physiopathology implicates microbial proliferation, formation of immune complex against skin and activation and migration of neutrophils and increasing factors. The treatment is based on corticosteroids and non steroid anti-inflammatory drugs or dapsone.
authors.affiliation: Département de dermatologie, CHU Saint-Jacques, 2, place Saint-Jacques, 25030 Besancon cedex, France.
authors.forename: A-R
authors.initials: AR
authors.lastname: Guerre-Schmidt
authors.forename: F
authors.initials: F
authors.lastname: Pelletier
authors.forename: F
authors.initials: F
authors.lastname: Carbonnel
authors.forename: P
authors.initials: P
authors.lastname: Humbert
authors.forename: F
authors.initials: F
authors.lastname: Aubin
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001168:Arthritis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones