Synthesis and study of anti-inflammatory activity of some novel cyclophane amides.
Macrocyclic di- and tetra-amides with thia- and oxylinkages were synthesized and screened for in vitro anti-inflammatory activity. Cyclophane diamide 15 showed a dose-dependent activity, while the other cyclophane amides 16-20 exhibited mild activity.
Rajakumar
Perumal
P
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India. perumalrajakumar@hotmail.com <perumalrajakumar@hotmail.com>
Mohammed Abdul Rasheed
A
A
Iman Rabia
A
A
Chamundeeswari
D
D
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D004988:Ethers, Cyclic / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004988:Ethers, Cyclic; D010880:Piperidines