title: Acute systemic immune activation following conjunctival exposure to staphylococcal enterotoxin B.
abstract: Conjunctival exposure to the Staphylococcus aureus superantigen staphylococcal enterotoxin B (SEB) may occur accidentally, as a result of bioterrorism, or during colonization or infection of the external eye. Using human leukocyte antigen class II transgenic mice, we show for the first time that conjunctival exposure to SEB can cause robust systemic immune activation.
authors.affiliation: Department of Immunology, Mayo Clinic College of Medicine, 200 First St., SW, Rochester, MN 55905, USA.
authors.forename: Govindarajan
authors.initials: G
authors.lastname: Rajagopalan
authors.forename: Michele K
authors.initials: MK
authors.lastname: Smart
authors.forename: Robin
authors.initials: R
authors.lastname: Patel
authors.forename: Chella S
authors.initials: CS
authors.lastname: David
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003228:Conjunctiva / Q000276:immunology* / Q000382:microbiology*; D004768:Enterotoxins / Q000633:toxicity*; D006680:HLA Antigens / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D004768:Enterotoxins; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; C031818:enterotoxin B, staphylococcal