Genotoxic activity of halogenated phenylglycine derivatives.
The discovery of genotoxic amino acids derived from phenylglycine, and possessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.
Boto
Alicia
A
Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez, 3, 38206-La Laguna, Tenerife, Spain. alicia@ipna.csic.es <alicia@ipna.csic.es>
Gallardo
Juan A
JA
Hernández
Rosendo
R
Ledo
Francisco
F
Muñoz
Ana
A
Murguía
José R
JR
Menacho-Márquez
Mauricio
M
Orjales
Aurelio
A
Saavedra
Carlos J
CJ
D001550:Benzamidines / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D006219:Halogens / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001550:Benzamidines; D006219:Halogens; C032157:benzamidine; D009584:Nitrogen; D010100:Oxygen; D005998:Glycine