title: Enteral feeding and early outcomes of patients undergoing allogeneic stem cell transplantation following myeloablative conditioning.
abstract: The purpose of this study was to evaluate the impact of enteral nutrition on early outcome of patients after myeloablative allogeneic stem cell transplantation (allo-SCT). From January 2001 to January 2003, 22 patients agreed to receive enteral nutrition via a nasogastric feeding tube; the remaining 23 patients received parenteral nutrition (n=22) or standard oral feeding (n=1). Early complications and factors influencing 100-day overall survival (OS) were investigated. Patients who received enteral nutrition developed less often acute-grade III/IV graft-versus-host disease (18%) than those who did not (35%) (P=0.011). In addition, this group showed lower mortality from infection during the first 100 days after transplantation. In multivariate analyses, only the absence of enteral nutrition was found to adversely influence 100-day OS with a hazard ratio of 8.3. Enteral nutrition is a safe and effective method for feeding allo-SCT patients. A randomized trial is warranted to confirm its advantage on early patient outcome.
authors.affiliation: Service de Nutrition, CHU, Lille, France.
authors.forename: David
authors.initials: D
authors.lastname: Seguy
authors.forename: Céline
authors.initials: C
authors.lastname: Berthon
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Micol
authors.forename: Stéphane
authors.initials: S
authors.lastname: Darré
authors.forename: Jean-Hugues
authors.initials: JH
authors.lastname: Dalle
authors.forename: Sylvain
authors.initials: S
authors.lastname: Neuville
authors.forename: Francis
authors.initials: F
authors.lastname: Bauters
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Jouet
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yakoub-Agha
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001854:Bone Marrow Cells / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000628:therapy; D009196:Myeloproliferative Disorders / Q000628:therapy; D033581:Stem Cell Transplantation / Q000401:mortality; D016019:Survival Analysis; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome