Neuronal RNA granules: movers and makers.
RNA localization contributes to cell polarity and synaptic plasticity. Evidence will be discussed that RNA transport and local translation in neurons may be more intimately linked than originally thought. Second, neuronal RNA granules, originally defined as intermediates involved in mRNA transport, are much more diverse in their composition and functions than previously anticipated. We focus on three classes of RNA granules that include transport RNPs, stress granules, and P bodies and discuss their potential functions in RNA localization, microRNA-mediated translational regulation, and mRNA degradation.
Kiebler
Michael A
MA
Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria. michael.kiebler@meduniwien.ac.at
Bassell
Gary J
GJ
D000818:Animals; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000235:genetics; D012313:RNA / Q000235:genetics / Q000378:metabolism*; D020871:RNA Stability; D034443:RNA Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger; D012313:RNA