Clinical observation on effect of Kaixin capsule in treating 40 patients with diabetic myocardial ischemia.
OBJECTIVE
To observe the effect of Kaixin Capsule (KXC) on myocardial ischemia and plasma endothelin (ET) level in patients with diabetic heart disease (DHD).


METHODS
The 72 subjects for observation were randomly selected from inpatients whose diagnosis fit to the standard of DHD. The 32 patients allocated in the control group were treated with conventional Western medicine, and the 40 patients in the treated group were treated with conventional Western medicine in combination with KXC, with the therapeutic course for both groups as 60 days.


RESULTS
On ECG, the total effective rate and markedly effective rate in the treated group was 85.0% and 37.5% respectively, higher than those in the control group's 68.7% and 28.1% respectively, and showing significant difference between the two groups (P < 0.05). The level of ET in patients in both groups was significantly higher than normal range, after treatment, but reduced to different extent, and the comparison between them also showed that the difference was significant (P < 0.05).


CONCLUSIONS
KXC might, by way of inhibiting and blocking the release of ET, lower its level in plasma so as to improve the myocardial ischemic condition of patients with DHD.
Xue
Jun
J
Department of Science and Technique, Guangzhou University of TCM, Guangzhou, China. xuejun1969@hotmail.com
Liu
Mei
M
Chen
Jing-he
JH
D000328:Adult; D001786:Blood Glucose; D048909:Diabetes Complications / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004562:Electrocardiography; D016232:Endothelins / Q000097:blood; D005260:Female; D005907:Gliclazide / Q000008:administration & dosage; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D007004:Hypoglycemic Agents; C000606487:kaixin; D005907:Gliclazide