Cardiac [123I]metaiodobenzylguanidine scintigraphy for vascular Parkinsonism.
The purpose of our study was to prospectively evaluate cardiac [(123)I]metaiodobenzylguanidine (MIBG) uptake in patients with cerebrovascular disease (CVD) who develop clinical symptoms of vascular Parkinsonism (VP). A total of 19 consecutive patients who developed Parkinsonism during the course of their CVD were enrolled in the study; 16 age-matched subjects, and 30 patients with Parkinson's disease (PD) were also evaluated with cardiac MIBG uptake. MIBG uptake was assessed using the ratio of the heart to the upper mediastinum (H/M) according to planar scintigraphic data. The mean H/M ratio was significantly higher in patients with VP than in those with PD (2.28 +/- 0.41 vs. 1.27 +/- 0.13; P < 0.001). MIBG uptake did not differ between VP and controls (2.46 +/- 0.33; P > 0.05). Our findings suggest that myocardial postganglionic sympathetic dysfunction found in PD is absent in most patients with VP. MIBG single photon emission computed tomography imaging may be useful to help distinguish between PD and VP patients in clinical practice.
Kim
Joong-Seok
JS
Department of Neurology, The Catholic University of Korea, Seoul, Korea.
Lee
Phil-Hyu
PH
Lee
Kwang-Soo
KS
Park
Jeong-Wook
JW
Kim
Yeong-In
YI
Chung
Yong-An
YA
Kim
Sung-Hoon
SH
Kim
Seung-Hyun
SH
Kim
Juhan
J
Choi
Yun-Young
YY
Kim
Hee-Tae
HT
D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics*; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D011877:Radionuclide Imaging / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine