Effect of poloxamers on nifedipine microparticles prepared by Hot Air Coating technique.
The Hot Air Coating (HAC) technique was used to prepare microparticles consisting of 30% nifedipine coated with different lipid mixtures. Cetearyl alcohol or cetearyl alcohol and 5% or 15% of a poloxamer (Pluronic F68 or Pluronic F127) were used as excipients. HAC products were analyzed in terms of morphology, flowability, thermal properties and nifedipine release behaviour, in order to elucidate the role played by the Pluronics on the physico-chemical and pharmaceutical characteristics of microparticles. HAC particles were spherical and their surface appeared scale-worked; thermal studies demonstrated the existence of relevant interactions among the system components and the dissolution experiments led to the hypothesis that the drug is released primarily by diffusion through the lipid coating: the poloxamer and its concentration have a significant influence on the pharmaceutical properties of the dosage form, as shown by the a parameter of Weibull model.
Pattarino
Franco
F
DISCAFF, School of Pharmacy, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy. pattarino@pharm.unipmn.it
Giovannelli
Lorella
L
Bellomi
Sonja
S
D000465:Algorithms; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D005233:Fatty Alcohols; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D009543:Nifedipine / Q000008:administration & dosage* / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D013608:Tablets, Enteric-Coated
D005233:Fatty Alcohols; D013501:Surface-Active Agents; D013608:Tablets, Enteric-Coated; D020442:Poloxamer; C419308:cetearyl alcohol; D009543:Nifedipine