Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice.
A nasal formulation of mometasone furoate (MF) is advantageous in avoiding systemic activity characteristic of glucocorticoids when it is applied topically. To confirm antiallergic effects of this glucocorticoid formulation elaborately, we investigated whether the drug can suppress the production of IgE antibodies and related cytokines. It we showed that IgE production induced in mice immunized via intranasal route was significantly reduced when the mice were administered MF intranasally. Further, MF was effective in inhibiting production of type-2 helper T cell cytokines in vivo and in vitro. These results provide a immunopharmacological basis for clinical efficacy of this drug.
Magari
Masaki
M
Department of Bioscience and Biotechnology, Okayama University, Okayama, Japan.
Ikeda
Mika
M
Asakura
Miki
M
Kanayama
Naoki
N
Ogawa
Masami
M
Ohmori
Hitoshi
H
D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D002460:Cell Line; D004342:Drug Hypersensitivity / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D007114:Immunization / Q000379:methods; D007073:Immunoglobulin E / Q000276:immunology* / Q000378:metabolism; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism; D007279:Injections, Subcutaneous; D015847:Interleukin-4 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D000068656:Mometasone Furoate; D009574:Nitro Compounds / Q000008:administration & dosage / Q000276:immunology; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D011244:Pregnadienediols / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
D018926:Anti-Allergic Agents; D007074:Immunoglobulin G; D009574:Nitro Compounds; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D015847:Interleukin-4; D007073:Immunoglobulin E; D010047:Ovalbumin