title: Cryptococcus gattii infection: characteristics and epidemiology of cases identified in a South African province with high HIV seroprevalence, 2002-2004.
abstract: We describe 46 Cryptococcus gattii-infected persons identified by population-based surveillance conducted in South Africa. Most patients with C. gattii infection presented with meningitis. The mortality rate during hospitalization was 36%. We found no significant differences between persons with and persons without C. gattii infection with regard to clinical presentation, acquired immunodeficiency syndrome diagnosis, concomitant conditions, or prior opportunistic infections. C. gattii isolates had low MICs to the tested antifungal drugs.
authors.affiliation: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors.forename: Juliette
authors.initials: J
authors.lastname: Morgan
authors.forename: Kerrigan M
authors.initials: KM
authors.lastname: McCarthy
authors.forename: Susan
authors.initials: S
authors.lastname: Gould
authors.forename: Ke
authors.initials: K
authors.lastname: Fan
authors.forename: Beth
authors.initials: B
authors.lastname: Arthington-Skaggs
authors.forename: Naureen
authors.initials: N
authors.lastname: Iqbal
authors.forename: Karen
authors.initials: K
authors.lastname: Stamey
authors.forename: Rana A
authors.initials: RA
authors.lastname: Hajjeh
authors.forename: Mary E
authors.initials: ME
authors.lastname: Brandt
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003454:Cryptococcus / Q000145:classification*; D005260:Female; D015528:HIV Seroprevalence; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008403:Mass Screening / Q000379:methods; D016919:Meningitis, Cryptococcal / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D008875:Middle Aged; D018571:Sentinel Surveillance; D013019:South Africa / Q000453:epidemiology