[Change of zero-stress state of portal vein in the rat during the pathogenesis of intrahepatic portal hypertension].
A model of intrahepatic portal hypertension was established in SD rats by injection of carbon tetrachloride (CCl4). By observing the opening angle of the portal vein, the zero-stress state of the portal veins was studied at different time during the pathogenesis of intrahepatic portal hypertension. After CCl4 injection, the opening angles of the portal veins were increased, in the tenth week, they were much greater than those in the corresponding controls (P<0.05). The results suggest that during the pathogenesis of portal hypertension, unequal remodeling exists in the portal veins to change its biomechanical properties, and the residual stress and strain of the portal veins in portal hypertensive rats are greater than those in normal controls.
Shi
Bin
B
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Zhu
Liang
L
Xie
Weifen
W
Zhang
Zhongbing
Z
Wu
Guoqiang
G
D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D004195:Disease Models, Animal; D006975:Hypertension, Portal / Q000139:chemically induced / Q000503:physiopathology*; D007279:Injections, Subcutaneous; D008297:Male; D011169:Portal Vein / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical