Is dosage of hormone replacement therapy related with endometrial polyp formation?
OBJECTIVE
To evaluate the effect of different doses of hormone replacement therapy (HRT) on endometrial polyp formation.


METHODS
398 menopausal women were initially evaluated through transvaginal ultrasound and patients who already had endometrial polyps were excluded from the study. One hundred and six (26.6%) eligible patients were enrolled and randomized into two groups of 53 patients to receive two different doses of HRT.


RESULTS
Six patients with endometrial polyps were detected in the first group and one patient in the second one (p = 0.0502 for total chi-square and p = .1172 for chi-square with continuity correction) after a mean duration of treatment of 26 months and 28,5 months, respectively. There was no difference in the mean number or the mean volume of the polyps between the two subgroups with positive results.


CONCLUSIONS
Our study showed that endometrial polyp formation may be related with HRT dosage.
Iatrakis
G
G
Technological Educational Institution of Athens, Greece.
Zervoudis
S
S
Antoniou
E
E
Tsionis
C
C
Pavlou
A
A
Kourounis
G
G
Siskos
K
K
D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D009640:Norethindrone / Q000008:administration & dosage*; D011127:Polyps / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
D004338:Drug Combinations; D004958:Estradiol; D009640:Norethindrone