title: The pathogenesis of anaemia in goats experimentally infected with Trypanosoma congolense or Trypanosoma brucei: use of the myeloid:erythroid ratio.
abstract: The present study examined the development of anaemia in Small East African goats experimentally infected with Trypanosoma congolense or Trypanosoma brucei. Experimental goats received a primary trypanosome challenge on day 0, treated with diminazene aceturate on day 49 and received a secondary trypanosome challenge on day 77 of the 136-day experiment. Both primary and secondary challenges were characterised by reduced peripheral erythrocyte counts, fall in packed cell volume (PCV), hypohaemoglobinaemia and reductions in the myeloid:erythroid ratios (M:E) compared with the uninfected goats. The progressive reduction in the M:E ratios denoted increased erythrogenesis in response to increased destruction of erythrocytes in blood by infecting trypanosomes or their products. The more rapid fall in M:E ratio in T. congolense infections shows that this parasite causes more severe clinical pathological effects in goats than T. brucei.
authors.affiliation: Department of Veterinary Medicine, Makerere University, P.O. Box 7062, Kampala, Uganda. biryomumaisho@vetmed.mak.ac.ug
authors.forename: S
authors.initials: S
authors.lastname: Biryomumaisho
authors.forename: E
authors.initials: E
authors.lastname: Katunguka-Rwakishaya
mesh_terms: D000740:Anemia / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D004906:Erythrocyte Count / Q000662:veterinary; D015511:Goat Diseases / Q000097:blood*; D006041:Goats; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D014346:Trypanosoma brucei brucei; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000097:blood / Q000150:complications / Q000662:veterinary*
chemical_list: D006454:Hemoglobins