title: Double roles of hydroxycinnamic acid derivatives in protection against lysozyme oxidation.
abstract: Oxidative damage to protein has been implicated in a number of diseases. Much interest has been focused on preventing oxidative damage to protein. Here we showed that hydroxycinnamic acid derivatives (HCA) were able to inhibit the cross-linking of protein induced by riboflavin-mediated photooxidation. HCA were also found to strongly protect lysozyme from gamma rays irradiation. The antioxidative properties of HCA were further studied by laser flash photolysis. Mechanism of antioxidant activities of HCA on lysozyme oxidation was discussed. HCA were found to protect protein against oxidation by scavenging oxidizing species and repairing the damaged protein.
authors.affiliation: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Hongping
authors.initials: H
authors.lastname: Zhu
authors.forename: Shimou
authors.initials: S
authors.lastname: Chen
authors.forename: Shumei
authors.initials: S
authors.lastname: Hao
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Wang
authors.forename: Side
authors.initials: S
authors.lastname: Yao
mesh_terms: D003373:Coumaric Acids / Q000378:metabolism*; D017665:Hydroxyl Radical / Q000378:metabolism; D009113:Muramidase / Q000378:metabolism*; D010084:Oxidation-Reduction; D010777:Photochemistry
chemical_list: D003373:Coumaric Acids; D017665:Hydroxyl Radical; D009113:Muramidase