title: Pathway classification of TCA cycle.
abstract: The structural analysis of large metabolic networks exhibits a combinatorial explosion of elementary modes. A new method of classification has been developed [called aggregation around common motif (ACoM)], which groups elementary modes into classes with similar substructures. This method is applied to the tricarboxylic acid cycle and metabolite carriers. The analysis of this network evidences a great number of elementary flux modes (204) despite the low number of reactions (23). The ACoM is used to class these elementary modes in a low number of sets (8) with biological meanings.
authors.affiliation: Physiopathologie Mitochondriale, Inserm U688, University Bordeaux 2, France. sabine.peres@etud.u-bordeaux2.fr
authors.forename: S
authors.initials: S
authors.lastname: Pérès
authors.forename: M
authors.initials: M
authors.lastname: Beurton-Aimar
authors.forename: J P
authors.initials: JP
authors.lastname: Mazat
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000465:Algorithms; D000818:Animals; D002468:Cell Physiological Phenomena; D002952:Citric Acid Cycle / Q000502:physiology*; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D020543:Proteome / Q000145:classification / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020543:Proteome