title: Awajanomycin, a Cytotoxic gamma-lactone-delta-lactam metabolite from marine-derived Acremonium sp. AWA16-1.
abstract: The new fungal metabolite awajanomycin (1), which has gamma-lactone-delta-lactam rings, was isolated from the marine-derived fungus Acremonium sp. AWA16-1, which had been collected from sea mud off Awajishima Island in Japan. The structure of 1 was elucidated by spectroscopic analysis and chemical methods. Awajanomycin (1) and its derivative (2) inhibited the growth of A549 cells with IC(50) values of 27.5 and 46.4 microg/mL, respectively.
authors.affiliation: Laboratory of Applied Bioorganic Chemistry, Marine Biotechnology Institute Co. Ltd., 3-75-1 Heita, Kamaishi, Iwate 026-0001, Japan. jang.haehyuk@mbio.jpo
authors.forename: Jae-Hyuk
authors.initials: JH
authors.lastname: Jang
authors.forename: Kaneo
authors.initials: K
authors.lastname: Kanoh
authors.forename: Kyoko
authors.initials: K
authors.lastname: Adachi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007769:Lactams; C514409:awajanomycin