Effects of vitamin E supplementation on oxidative stress at rest and after exercise to exhaustion in athletic students.
OBJECTIVE
The purpose of this study is to determine the effect following exercise to exhaustion of vitamin E supplementation on oxidative stress in athletic students.


METHODS
Twenty male students voluntarily participated in the study and were randomly assigned (double blind) to either a vitamin E (daily dose of 450 mg of a-tocopherol for a period of 8 weeks) or a placebo group (took capsules containing 450 mg of lactose for 8 weeks). Before and after 8 weeks blood samples were collected at rest and after exercise to exhaustion. Oxidative stress markers were malondialdehyde (MDA), carbonylated proteins (CP) and creatine kinase (CK). Also, the effect of vitamin E on ergometer cycling time, as an example of endurance performance, was evaluated.


RESULTS
ANOVA and independent t-tests indicated that vitamin E supplementation did not significantly change (P > 0.05) MDA, CP and CK values at rest, after exercise to exhaustion, and cycling time, but plasma volume after exercise to exhaustion significantly decreased (P < 0.05).


CONCLUSIONS
Although vitamin E supplementation had no effect on exercise performance or capacity in athletic students, further investigation is required using larger numbers of subjects and measures of vitamin E before unequivocal conclusion can be stated.
Gaeini
A A
AA
Faculty of Physical Education, University of Tehran, Tehran, Iran.
Rahnama
N
N
Hamedinia
M R
MR
D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000008:administration & dosage*; D003402:Creatine Kinase / Q000097:blood / Q000187:drug effects; D019587:Dietary Supplements; D004311:Double-Blind Method; D016552:Ergometry; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018763:Muscle Fatigue / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects; D010953:Plasma Volume / Q000187:drug effects; D050050:Protein Carbonylation / Q000187:drug effects; D012146:Rest / Q000502:physiology*; D013177:Sports; D013334:Students; D014810:Vitamin E / Q000008:administration & dosage*
D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D003402:Creatine Kinase