title: Towards a definition of the "practical" epileptogenic zone: a case of epilepsy with dual pathology.
abstract: Presurgical evaluation for patients with drug-resistant epilepsy requires the definition of various zones that have a variable spatial relationship with the epileptogenic zone. All the available methods to directly measure the actual seizure-onset zone and to define "the minimum amount of cortical tissue that must be resected to produce seizure-freedom" have significant limitations. We report on the case of a patient with dual pathology (hippocampal sclerosis and a post-traumatic scar) and discuss the contribution of the various presurgical investigations that led to surgery and seizure-freedom.
authors.affiliation: Departments of Neurology and of Neurosurgery, Hôpitaux Universitaires de Strasbourg, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Chassagnon
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Valenti
authors.forename: Cécile
authors.initials: C
authors.lastname: Sabourdy
authors.forename: Philippe
authors.initials: P
authors.lastname: Esposito
authors.forename: Pierre
authors.initials: P
authors.lastname: Kehrli
authors.forename: Alexis
authors.initials: A
authors.lastname: Arzimanoglou
authors.forename: Philippe
authors.initials: P
authors.lastname: Ryvlin
authors.forename: Philippe
authors.initials: P
authors.lastname: Kahane
authors.forename: Edouard
authors.initials: E
authors.lastname: Hirsch
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology; D001927:Brain Diseases / Q000150:complications; D001930:Brain Injuries / Q000150:complications*; D004569:Electroencephalography / Q000145:classification*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D012598:Sclerosis; D012640:Seizures / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000927:Anticonvulsants