Biological evaluation of chalcones and analogues as hypolipidemic agents.
In order to evaluate the anti-hyperlipidemic effect of synthetic chalcones and some analogues, nineteen compounds with different substituents in both rings were synthesized and hypolipidemic activities were measured in vivo using Triton WR1339 acute and hypercaloric chronic assays. 4',4-dichlorochalcone, 3',4',4-trichlorochalcone, and 4'-chlorochalcone gave an excellent decrease in serum total cholesterol and triglycerides in the acute assay. These compounds also showed significant anti-lipidemic activity in the chronic assay.
Santos
Lorena
L
Departament of Biochemistry, Universidade Federal de Santa Catarina (UFSC), Florianopolis, Brazil.
Curi Pedrosa
Rozangela
R
Correa
Rogério
R
Cechinel Filho
Valdir
V
Nunes
Ricardo José
RJ
Yunes
Rosendo Augusto
RA
D000818:Animals; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
C515110:4',4-dichlorochalcone; D047188:Chalcones; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D014280:Triglycerides