title: Isolation of two polyketide synthase gene fragments from the uncultured microbial symbiont of the marine bryozoan Bugula neritina.
abstract: "Candidatus Endobugula sertula," the uncultured microbial symbiont of the bryozoan Bugula neritina, produces ecologically and biomedically important polyketide metabolites called bryostatins. We isolated two gene fragments from B. neritina larvae that have high levels of similarity to polyketide synthase genes. These gene fragments are clearly associated with the symbiont and not with the host.
authors.affiliation: Graduate College of Marine Studies, University of Delaware, Lewes 19958, USA. nlopanik@umich.edu
authors.forename: Nicole B
authors.initials: NB
authors.lastname: Lopanik
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Targett
authors.forename: Niels
authors.initials: N
authors.lastname: Lindquist
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000235:genetics*; D002013:Bryozoa / Q000382:microbiology*; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D010802:Phylogeny; D048630:Polyketide Synthases / Q000737:chemistry / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013559:Symbiosis
chemical_list: D004269:DNA, Bacterial; D048630:Polyketide Synthases