Cancer specific Mucin-1 glycoforms are expressed on multiple myeloma.
Present therapies cannot cure the large majority of patients with multiple myeloma (MM) and therefore new treatment strategies are imperative. This study analysed the different glycosylation profiles of Mucin-1 (MUC1) on MM and acute myeloid leukaemia (AML) cells using a series of anti-MUC1 antibodies. Seventy-three per cent of the MM patients had plasma cells that expressed the fully glycosylated forms of MUC1. In contrast to controls, normal bone marrow cells and AML cells, the differentiation-dependent and cancer-associated glycoforms of MUC1 were present on 59% and 36% MM tumour cells respectively. This indicated that aberrantly glycosylated MUC1 is a potential immunotherapeutic target in MM patients.
Cloosen
Silvie
S
Department of Internal Medicine, Division of Haematology and Oncology, University Hospital Maastricht, Maastricht, The Netherlands. s.cloosen@immuno.unimaas.nl
Gratama
Janwillem
J
van Leeuwen
Ellen B M
EB
Senden-Gijsbers
Birgit L M G
BL
Oving
Ellis B H
EB
von Mensdorff-Pouilly
Silvia
S
Tarp
Mads A
MA
Mandel
Ulla
U
Clausen
Henrik
H
Germeraad
Wilfred T V
WT
Bos
Gerard M J
GM
D000208:Acute Disease; D000912:Antibodies, Neoplasm / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism*; D001853:Bone Marrow / Q000276:immunology; D005434:Flow Cytometry; D006031:Glycosylation; D006801:Humans; D007951:Leukemia, Myeloid / Q000378:metabolism; D018396:Mucin-1; D009077:Mucins / Q000276:immunology / Q000378:metabolism*; D009101:Multiple Myeloma / Q000276:immunology / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D009363:Neoplasm Proteins