title: [Development of the anti-influenza H5N1 vaccines worldwide and in Russia].
abstract: Article is dedicated to analytical investigation of the problem of current technologies in construction and manufacturing of anti-influenza vaccines. Epidemiological events in July-November 2005 in Russia (mainly in Siberia) and later in Ukraine showed that Health Care system was not ready for that turn over of epidemiological situation. It was completely the same situation in other countries. There are two general questions of a readiness in pre-pandemic situation: level of a diagnostic monitoring of epidemiological situation and preparedness to fast production of actual vaccine preparations. First task can be solved by immediate production of diagnostic sets for regional branches of National WHO Centers, and a second one depends on application of a novel approaches in construction of a anti-influenza vaccines. The construction of anti-influenza vaccines is based on genetic engineering (reverse genetics) and manipulation with plasmids carried out basic viral genes. Reassortation technology for preparation of hybrid viruses is going to the past by objective reasons. Advanced technologies are safety in laboratories and in manufacturing facilities. Moreover, genetic engineering in this field allows to planing the construction of vaccines bank, when the prognoses for actual viruses include more then two strains with different antigenic properties.
authors.forename: O I
authors.initials: OI
authors.lastname: Kiselev
authors.forename: L M
authors.initials: LM
authors.lastname: Tsybalova
authors.forename: V I
authors.initials: VI
authors.lastname: Pokrovskiĭ
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D015195:Drug Design; D005814:Genes, Viral / Q000276:immunology; D005818:Genetic Engineering; D014943:Global Health; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000235:genetics; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D010957:Plasmids / Q000276:immunology; D012426:Russia / Q000453:epidemiology; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines