Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.
Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.
Chiang
Lisa Y
LY
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Ejzykowicz
Daniele E
DE
Tian
Zong-Qiang
ZQ
Katz
Leonard
L
Filler
Scott G
SG
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D001232:Aspergillus fumigatus / Q000187:drug effects*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D016896:Treatment Outcome
D000935:Antifungal Agents; D011714:Pyrans; C014964:ambruticin