title: Use of subcutaneous DDAVP in infants with central diabetes insipidus.
abstract: Traditional methods for treating central diabetes insipidus during infancy, such as fluid therapy or the use of intranasal hormone replacement, have significant potential limitations. In a retrospective study of infants with diabetes insipidus, we examined outcome using subcutaneous (sc) DDAVP, and compared this to infants treated with intranasal lysine vasopressin or DDAVP. After in-patient dosage titration, outpatients' serum sodium concentrations were maintained in a narrower range in the sc group compared with the intranasal group, and the percentage of serum sodium concentrations within the normal range was greater in the sc group. There were no significant complications in either group. We conclude that DDAVP administered subcutaneously can be a safe and effective alternative to traditionally recommended treatments of central diabetes insipidus during infancy.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, State University of New York, Stony Brook, NY 11794-8111, USA.
authors.forename: Ernesto J
authors.initials: EJ
authors.lastname: Blanco
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Lane
authors.forename: Naghma
authors.initials: N
authors.lastname: Aijaz
authors.forename: Denise
authors.initials: D
authors.lastname: Blumberg
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wilson
mesh_terms: D000281:Administration, Intranasal; D050034:Antidiuretic Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007279:Injections, Subcutaneous; D008236:Lypressin / Q000008:administration & dosage*; D008297:Male; D012189:Retrospective Studies
chemical_list: D050034:Antidiuretic Agents; D008236:Lypressin; D003894:Deamino Arginine Vasopressin