title: Antimycobacterial activity of geranylated furocoumarins from Tetradium daniellii.
abstract: Seven geranylated furocoumarins were isolated from the fruits of TETRADIUM DANIELLII (Benn.) T.G. Hartley (Rutaceae) and tested for their antimycobacterial activity against MYCOBACTERIUM FORTUITUM, M. SMEGMATIS and M. PHLEI. They were shown to be highly active, with minimal inhibitory concentrations (MICs) ranging from 8 to 64 microg/mL. Xanthotoxin and xanthotoxol, representing furocoumarins lacking the lipophilic geranyl side chain, were tested similarly and were shown to be inactive. Geraniol alone was inactive as well. The antimycobacterial activity of the substances was dependent on the position and polarity of the geranyl moiety. The compounds were purified using chromatographic methods. Structure elucidation was achieved with 1D and 2D NMR experiments.
authors.affiliation: Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Graz, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Adams
authors.forename: Sabine
authors.initials: S
authors.lastname: Ettl
authors.forename: Olaf
authors.initials: O
authors.lastname: Kunert
authors.forename: Abraham Abebe
authors.initials: AA
authors.lastname: Wube
authors.forename: Ernst
authors.initials: E
authors.lastname: Haslinger
authors.forename: Franz
authors.initials: F
authors.lastname: Bucar
authors.forename: Rudolf
authors.initials: R
authors.lastname: Bauer
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D005638:Fruit / Q000737:chemistry; D011564:Furocoumarins / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D009161:Mycobacterium; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D011564:Furocoumarins