title: Cardiac isoform of alpha 2 macroglobulin, an early diagnostic marker for cardiac manifestations in AIDS patients.
abstract: This study investigated the possible role of the cardiac isoform of alpha 2-macroglobulin (CA2M) as an early diagnostic marker for HIV-associated cardiovascular manifestations. A total of 349 samples were analysed by Western blot and quantified by sandwich enzyme-linked immunosorbent assay. The levels of CA2M present in sera of HIV-associated cardiac diseases were significantly higher than those of HIV without cardiac involvement and healthy sera. CA2M may act as a novel diagnostic marker to identify cardiac manifestations in HIV/AIDS patients.
authors.affiliation: Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamilnadu, India.
authors.forename: Subbiah
authors.initials: S
authors.lastname: Ramasamy
authors.forename: Reghunath
authors.initials: R
authors.lastname: Omnath
authors.forename: Andiappan
authors.initials: A
authors.lastname: Rathinavel
authors.forename: Perumal
authors.initials: P
authors.lastname: Kannan
authors.forename: Perundurai S
authors.initials: PS
authors.lastname: Dhandapany
authors.forename: Ponnambalam
authors.initials: P
authors.lastname: Annapoorani
authors.forename: Pitchai
authors.initials: P
authors.lastname: Balakumar
authors.forename: Manjeet
authors.initials: M
authors.lastname: Singh
authors.forename: Rajagopalan
authors.initials: R
authors.lastname: Ganesh
authors.forename: Govindan Sadasivam
authors.initials: GS
authors.lastname: Selvam
mesh_terms: D015415:Biomarkers / Q000097:blood; D015153:Blotting, Western; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D006331:Heart Diseases / Q000175:diagnosis* / Q000821:virology*; D006801:Humans; D020033:Protein Isoforms / Q000032:analysis*; D012680:Sensitivity and Specificity; D000511:alpha-Macroglobulins / Q000032:analysis*
chemical_list: D015415:Biomarkers; D020033:Protein Isoforms; D000511:alpha-Macroglobulins