Assessing unit-price related remifentanil choice in rhesus monkeys.
Given a commodity available at different prices, a unit-price account of choice predicts preference for the cheaper alternative. This experiment determined if rhesus monkeys preferred remifentanil (an ultra-short-acting micro-opioid agonist) delivered at a lower unit price over a higher-priced remifentanil alternative (Phases 1 and 3). Choice between equal-priced alternatives also was assessed (Phase 2). A discrete-trials procedure was arranged in which three monkeys chose between two remifentanil alternatives by responding on one of two levers. Different prices were arranged by manipulating drug dose (0.3 and 0.1 microg/kg/injection) and/or the ratio requirement. Monkeys usually chose the larger-dose alternative even when it was more expensive. Only when unit prices were relatively high (e.g., large response requirements) did monkeys choose the cheaper (or equally priced) smaller-dose alternative. Employing larger doses (0.9 and 0.3 microg/kg/injection) attenuated the larger-dose preference. The results demonstrate that choice was not determined simply by unit price. An alternative model that employs demand-function analysis to generate choice predictions is proposed.
Galuska
Chad M
CM
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0632, USA. cgaluska@umich.edu
Winger
Gail
G
Hursh
Steven R
SR
Woods
James H
JH
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D008253:Macaca mulatta; D008297:Male; D009042:Motivation; D010880:Piperidines / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D017450:Receptors, Opioid, mu / Q000819:agonists*; D012055:Reinforcement Schedule; D000077208:Remifentanil
D000701:Analgesics, Opioid; D010880:Piperidines; D017450:Receptors, Opioid, mu; D000077208:Remifentanil