Effect of gonadotropin-releasing hormone analogue on thermal nociception in mice.
Intraperitoneal treatment with an analogue of gonadotropin-releasing hormone in doses of 0.004-450 microg/kg produced an analgesic effect on male mice in the hot plate test. Castration significantly elevated the nociceptive thresholds. In castrated mice the effects of the test peptide were less pronounced and had an algesic nature. Our results indicate that these effects depend on functional activity of the hypothalamic-pituitary-gonadal axis.
Bobyntsev
I I
II
Department of Pathophysiology, Kursk State Medical University. big@ksmu.kursknet.ru
Sever'yanova
L A
LA
Kryukov
A A
AA
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006358:Hot Temperature; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology; D009919:Orchiectomy; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology; D013737:Testis / Q000502:physiology
D000700:Analgesics; D007987:Gonadotropin-Releasing Hormone; C010661:surfagon