[The dynamics of changes glucose concentration of patients with ischemic stoke in chosen times of day].
Cerebral ischemic stroke which basic exponent is an sudden occurrence of neurological deficits is also characterized by deep disturbances of human organism homeostasis. It is known that many functions of a healthy human organism is subjected to the rhythmical changes during the twenty-four hours, and the state of illness can disturb them in a crucial way. The aim of the study was to examine the dynamics of changes of glucose concentration in blood of patients with acute phase of cerebral ischemic stroke in chosen times of day.


METHODS
The examinations were carried out on 16 non-diabetic patients (11 men, 5 women), aged between 57 and 76 where the cerebral ischemic stroke was confirmed by the Computer Tomography of the head. The patients were on high protein diet with total energy value of 2283 +/- 130.0 kcal per twenty-four hours in three meal times: at 09AM, 02PM, 06PM. The venous blood for examinations was drawn 6 times during the day: at 01AM, 05AM, 09AM, 01PM, 05PM, 09PM on the 1st, 3rd, 5th and 10th day after the stroke occurred. The following concentrations in blood were denoted glucose.


RESULTS
In patients with the acute phase of cerebral ischemic stroke the significant disorders of carbohydrate metabolism can be observed in times between 09AM and 01PM on both the 1st, 3rd and the 5th day of the duration of the disease.


CONCLUSIONS
The received results may take effect in the proofreading of pharmacological treatment with the consideration of the times of day.
Zagórski
Jarosław
J
Uniwersytet Medyczny w Lodzi, Szpital Kliniczny nr 2, Klinika Neurologii i Neurorehabilitacji z Oddziałem Udarowym. jarzag@poczta.onet.pl
Markuszewski
Leszek
L
Chudzik
Wiesław
W
Chmielewski
Henryk
H
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000097:blood* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors
D001786:Blood Glucose