Disseminated histoplasmosis mimicking laryngeal carcinoma from central India--a case report.
A 58 year old male, chronic smoker, with diabetes mellitus (Type II), residing in Madhya Pradesh presented with dysphagia, hoarseness, odynophagia and significant weight loss. Microlaryngoscopy showed reddish ulcerated area involving valleculae, and pharyngo-epiglottic fold. Histopathological examination showed foamy macrophages containing Histoplasma capsulatum. Patient initially responded to Azoles, relapsed three months after stopping the treatment and presented with oral lesions. Biopsy showed H. capsulatum, histologically as well as on culture. The mycelial phase converted to yeast phase on B.H.I.A. at 37 degrees C confirming the isolate as H. capsulatum. The patient responded well to amphotericin B.
Phatak
A M
AM
Department of Pathology, Jagjivan Ram Hospital, Mumbai.
Bhattacharya
Indranil
I
Misra
Vaibhav
V
Prabhu
Aruna Madan S R
AM
Natraj
Uma
U
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D018450:Disease Progression; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D007818:Laryngeal Diseases / Q000382:microbiology / Q000473:pathology*; D007828:Laryngoscopy; D007830:Larynx / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000382:microbiology; D012008:Recurrence
D000935:Antifungal Agents; D000666:Amphotericin B