title: Creating carbon-carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides.
abstract: In this perspective, an overview of our experiences on the application of samarium diiodide in organic synthesis for the preparation of amino acid and peptide analogues is presented. Three different carbon-carbon bond forming reactions are discussed, including side chain introductions, gamma-amino acid synthesis and acyl-like radical additions for the construction of C-C mimics of the peptidic bonds.
authors.affiliation: Center for Insoluble Proteins Structures, Department of Chemistry, Interdisciplinary Nanoscience Center, University of Aarhus, 8000, Aarhus C, Denmark.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ebran
authors.forename: Christina M
authors.initials: CM
authors.lastname: Jensen
authors.forename: Sine A
authors.initials: SA
authors.lastname: Johannesen
authors.forename: Jakob
authors.initials: J
authors.lastname: Karaffa
authors.forename: Karl B
authors.initials: KB
authors.lastname: Lindsay
authors.forename: Rolf
authors.initials: R
authors.lastname: Taaning
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
mesh_terms: D000478:Alkylation; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D005650:Fumarates / Q000138:chemical synthesis / Q000737:chemistry; D005998:Glycine / Q000737:chemistry; D006031:Glycosylation; D007454:Iodides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012493:Samarium / Q000737:chemistry*
chemical_list: D000577:Amides; D000596:Amino Acids; D004952:Esters; D005650:Fumarates; D007454:Iodides; D007659:Ketones; D010455:Peptides; D012493:Samarium; C446481:aliskiren; D002244:Carbon; C409809:samarium diiodide; D009584:Nitrogen; D005998:Glycine