title: Large-scale data management for high content screening.
abstract: High content screening (HCS) plays an important role in target selection in primary and secondary screening, but further developments in informatics and data management are needed for strategic implementation of HCS in the drug discovery process. An organization charter for the Research Informatics and Infrastructure Organization is described and is consists of four basic parts: Partner, Build Trust, Champion, and Core vs Noncore. The successful evolution of the charter over the last 5 yr is mapped using high-throughput screening and HCS data as an example. A future view of large-scale data management for the drug discovery process will incorporate all scientific information into multiple parameter type runs for many aspects of the science. This information will subsequently be aligned into a subset that an individual can digest and more easily choose the next appropriate steps.
authors.affiliation: Hoffmann-La Roche Inc., Global Research Infrastructure, Nutley, NJ, USA.
authors.forename: Leon S
authors.initials: LS
authors.lastname: Garfinkel
mesh_terms: D048088:Informatics; D019451:Information Management; D009938:Organizations; D046888:Tissue Array Analysis / Q000379:methods; D035502:Trust