title: Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines.
abstract: A series of chloro-fluorine containing chalcones (3) were prepared by Claisen-Schmidt condensation. Chalcone dibromides (4) were obtained by the bromination of chalcones at room temperature. Treatment of chalcone dibromides (4) with aryloxy acid hydrazides (5) in the presence of triethylamine gave chloro-fluorine containing hydroxy pyrazolines (7) rather than the expected 1-aryloxy-3-aryl-5-aryl pyrazoles (6). The structures of the newly synthesized compounds were confirmed by IR, NMR, mass and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities. Some compounds showed very good antibacterial activity and antifungal activity.
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangothri, Mangalore, Karnataka 574199, India. karthims02@rediffmail.com <karthims02@rediffmail.com>
authors.forename: Mari Sithambaram
authors.initials: MS
authors.lastname: Karthikeyan
authors.forename: Bantwal Shivarama
authors.initials: BS
authors.lastname: Holla
authors.forename: Nalilu Suchetha
authors.initials: NS
authors.lastname: Kumari
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047188:Chalcones / Q000737:chemistry; D015169:Colony Count, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D003904:Mitosporic Fungi / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047188:Chalcones; D011720:Pyrazoles