[Pharmacokinetics-pharmacodynamics of antifungal drugs. Consequences for therapeutic drug monitoring].
Despite pharmacokinetic-pharmacodynamic relationships were clearly evidenced for antifungal drugs by the use of experimental models, few target plasma concentrations could be determined from studies performed in patients. The main causes explaining this lack of data are reviewed and the possible use in humans of the parameters obtained from animal models is discussed.
Jullien
Vincent
V
Université Paris-Descartes, Faculté de Médecine, Paris, France. vincent.jullien@svp.aphp.fr
Lortholary
Olivier
O
D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D006801:Humans; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D013045:Species Specificity
D000935:Antifungal Agents