Time-frequency analysis reveals decreased high-frequency oscillations in writer's cramp.
High-frequency oscillations (HFO) have been suggested to reflect the activity of thalamocortical and/or intracortical neurons bursting at high frequencies. These circuits seem to be involved in pathophysiological mechanisms of focal dystonia. In healthy subjects, we characterized the spectrotemporal properties of HFO patterns evoked by dominant-hand median-nerve stimulation, using magnetoencephalography coupled with time-frequency analysis. Then, we investigated HFO in patients with writer's cramp and found that HFO patterns are strongly decreased in power and disorganized in time. This supports the assumption that abnormal HFOs reflect pathophysiological mechanisms occurring in focal dystonia, possibly resulting from a dysfunction of somatosensory processing.
Cimatti
Zoé
Z
Pierre & Marie Curie University, Paris, France. cimatti@chups.jussieu.fr
Schwartz
Denis P
DP
Bourdain
Frédéric
F
Meunier
Sabine
S
Bleton
Jean-Pierre
JP
Vidailhet
Marie
M
Renault
Bernard
B
Garnero
Line
L
D000328:Adult; D020821:Dystonic Disorders / Q000503:physiopathology*; D004558:Electric Stimulation / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D011930:Reaction Time; D013997:Time Factors