title: Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.
abstract: Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.
authors.affiliation: Institut für Medizinische Mikrobiologie, RWTH Aachen, Germany.
authors.forename: Heidrun
authors.initials: H
authors.lastname: Peltroche-Llacsahuanga
authors.forename: Sophie
authors.initials: S
authors.lastname: Goyard
authors.forename: Christophe
authors.initials: C
authors.lastname: d'Enfert
authors.forename: Stephan K-H
authors.initials: SK
authors.lastname: Prill
authors.forename: Joachim F
authors.initials: JF
authors.lastname: Ernst
mesh_terms: D018441:Biofilms / Q000254:growth & development*; D002176:Candida albicans / Q000201:enzymology / Q000254:growth & development* / Q000502:physiology; D003470:Culture Media; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D007527:Isoenzymes; D008364:Mannosyltransferases / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D011137:Polystyrenes
chemical_list: D003470:Culture Media; D005656:Fungal Proteins; D007527:Isoenzymes; D011137:Polystyrenes; D008364:Mannosyltransferases; C082696:protein O-mannosyltransferase