Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol.
A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.
Lee
Yun-Sang
YS
Department of Nuclear Medicine and Institute of Radiation Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Jongno-gu, Seoul 110-744, Korea.
Jeong
Jae Min
JM
Kim
Young Joo
YJ
Chang
Young Soo
YS
Lee
Hak Jeong
HJ
Son
Miwon
M
Lee
Jung Woo
JW
Yoon
Heung Sik
HS
Kang
Won Jun
WJ
Lee
Dong Soo
DS
Chung
June-Key
JK
Lee
Myung Chul
MC
Suh
Young-Ger
YG
D000107:Acetylation; D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007459:Iodized Oil / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods; D008657:Metabolic Clearance Rate; D051379:Mice; D009928:Organ Specificity; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use; D011933:Reagent Kits, Diagnostic; D014018:Tissue Distribution
C498051:188Re-4-hexadecyl-1,2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol lipiodol conjugate; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D011933:Reagent Kits, Diagnostic; D007459:Iodized Oil