title: Acute necrotizing encephalopathy of childhood in non-Asian patients: report of three cases and literature review.
abstract: Acute necrotizing encephalopathy of childhood is a novel type of parainfectious encephalopathy with a racial and geographic predilection, rarely reported from other than East Asian areas. The objective was to describe the clinical, imaging, and other laboratory findings of non-Asian patients with acute necrotizing encephalopathy. Data were collected from three patients diagnosed in Athens over a 4-year period plus 16 cases reported from other European and North American countries. One of the Greek children died, and the other two had a normal outcome. A neuropathologic examination in the fatal case showed edematous necrosis without inflammatory, reactive, or proliferative changes. Data from Greek and other non-Asian patients support the homogeneity of the disease worldwide.
authors.affiliation: Department of Neurology, University of Athens, Athens, Greece. smastr@otenet.gr
authors.forename: Sotiria D
authors.initials: SD
authors.lastname: Mastroyianni
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Gionnis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Voudris
authors.forename: Angeliki
authors.initials: A
authors.lastname: Skardoutsou
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizuguchi
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000208:ethnology / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D019579:Neocortex / Q000473:pathology*; D012196:Review Literature as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods; D044465:White People