title: The natural history of overactive bladder and stress urinary incontinence in older women in the community: a 3-year prospective cohort study.
abstract: OBJECTIVE
  This is the first study designed to describe the natural history of stress urinary incontinence (SUI) and overactive bladder (OAB), using validated symptom syndrome severity scores developed for the purpose.
  
  
  METHODS
  Two separate but related studies were involved, (i) a clinic sample (N = 2,052) from a randomised controlled trial (RCT) and (ii) a prospective cohort study (N = 12,750) with 3-year follow-up. Subjects in both studies were women aged 40 or more living in the community, approached using similar postal questionnaires. Severity scores using standardised urinary symptoms were derived for SUI and OAB from weightings obtained from logistic regression models of symptoms in relation to urodynamic diagnosis. Symptom severity scores were plotted for baseline and 3 years of follow-up to demonstrate the natural history of the main categories of SUI and OAB.
  
  
  RESULTS
  Overactive bladder and SUI syndrome severity scores showed good criterion validity in relation to relevant clinical measures and good test-retest reliability. OAB severity increased progressively with age including a period of accelerated increase in the 60s. In contrast, SUI severity showed two age-related peaks around age 60 and again at age 80. SUI severity also showed a more fluctuating pattern from year to year compared to OAB.
  
  
  CONCLUSIONS
  Contrasting patterns of natural history for OAB and SUI syndromes were identified consistent with differences in the patterns of related co-morbidities. Further studies are needed to confirm these findings.
authors.affiliation: Department of Health Sciences, University of Leicester, Leicester, United Kingdom. md5@leicester.ac.uk
authors.forename: M M K
authors.initials: MM
authors.lastname: Donaldson
authors.forename: J R
authors.initials: JR
authors.lastname: Thompson
authors.forename: R J
authors.initials: RJ
authors.lastname: Matthews
authors.forename: H M
authors.initials: HM
authors.lastname: Dallosso
authors.forename: C W
authors.initials: CW
authors.lastname: McGrother
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D053158:Nocturia / Q000503:physiopathology; D011446:Prospective Studies; D015203:Reproducibility of Results; D018570:Risk Assessment; D011795:Surveys and Questionnaires; D053201:Urinary Bladder, Overactive / Q000453:epidemiology / Q000503:physiopathology*; D014550:Urinary Incontinence, Stress / Q000453:epidemiology / Q000503:physiopathology*