title: The postantifungal effect (PAFE) of itraconazole, in comparison with those of miconazole and fluconazole, on Candida Species.
abstract: To study the postantifungal effect (PAFE) of itraconazole (ITCZ) against Candida species, we quantitated it using a newly introduced parameter T/C(T=time required for the drug-treated culture to reach 5-fold increase in turbidity; C=time required for the drug-free control culture to reach 5-fold increase in turbidity) referred as PAFE index and compared the results with those obtained for two other azole antifungal drugs fluconazole (FLCZ) and miconazole (MCZ). The mean values of PAFE index for ITCZ against three C. albicans strains were 1.28, 1.45, and 1.60 when exposed to the drug for 1 hr at concentrations of 1 x MIC, 2 x MIC and 4 x MIC, respectively. These values are similar to those for MCZ and appreciably higher than those for FLCZ. PAFE index values for ITCZ against each single strain of three non-albicans Candida species exposed to 2 x MIC of the drug for 1 hr were: 1.22 with C. glabrata, 1.63 with C. parapsilosis, and 3.90 with C. tropicalis. Again, comparable values were obtained for MCZ and lower values for FLCZ. The drug concentration for exposure and the duration of exposure only slightly or scarcely affected the PAFE of ITCZ, although the magnitude of the PAFE considerably varied among different strains or species tested. In general, ITCZ, as well as MCZ, produced greater extents of PAFE than those for FLCZ against C. albicans and several non-albicans Candida species.
authors.affiliation: Teikyo University Institute of Medical Mycology, Tokyo, Japan. kuchida@main.teikyo-u.ac.jp
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Uchida
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
authors.forename: Hideyo
authors.initials: H
authors.lastname: Yamaguchi
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects; D015725:Fluconazole / Q000494:pharmacology; D017964:Itraconazole / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D008825:Miconazole; D015725:Fluconazole