Treatment of facial angiofibroma of tuberous sclerosis using cultured epithelial autografts.
Treatment of facial angiofibroma of tuberous sclerosis is problematic, because the skin lesions involve entire dermis. Five patients aged from 14 to 33 (mean: 23.6) years old with angiofibroma of tuberous sclerosis were treated with cultured epithelial autografts between 1995 and 2004. The entire area of the facial lesions was excised using a razor to remove large nodules, and then the remaining lesions were further abraded to a rather deep layer of the dermis to smooth the skin and remove small nodules. Then a cultured autologous epithelium was grafted onto the wound. In all patients, epithelization was complete within 10 (mean: 9) days after the surgery. All patients were followed up for more than 6 months and showed neither depigmentation due to scar formation nor hypertrophic scars. In some patients, some pebbly regrowth had occurred at 5 years postoperatively, but the appearance was quite acceptable.
Hori
Keijiro
K
Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan. keijiro@prs.twmu.ac.jp
Soejima
Kazutaka
K
Nozaki
Motohiro
M
Sakurai
Hiroyuki
H
Takeuchi
Masaki
M
Yamaki
Takashi
T
Iwasaka
Susumu
S
Kono
Taro
T
Honda
Takashi
T
Isago
Tsukasa
T
D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000209:etiology / Q000601:surgery*; D004848:Epithelium / Q000637:transplantation*; D005153:Facial Neoplasms / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D046509:Tissue Culture Techniques; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications*