title: Beneficial effects of FK506 for experimental temporal lobe epilepsy.
abstract: FK506, originally classified as an immunosuppressant, may also be implicated in some events in the central nervous system. FK506 elicits both neuroprotective and neurotrophic effects in vitro. FK506 is neuroprotective for focal cerebral ischemia, but it is not clear whether FK506 has neuroprotective effects for other brain diseases. In this study, we investigated possible neuroprotective effects of FK506 in experimental temporal lobe epilepsy (TLE) induced by kainic acid (KA) or trimethyltin (TMT). In rat models, we observed marked protection against seizures, abnormal behaviors, and accompanying delayed neuronal damage in the hippocampus by the systemic injection of FK506.
authors.affiliation: Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nishimura
authors.forename: Hideki
authors.initials: H
authors.lastname: Imai
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
authors.forename: Akira
authors.initials: A
authors.lastname: Sawa
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D018690:Excitatory Amino Acid Agonists; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D020287:In Situ Nick-End Labeling; D007608:Kainic Acid; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D016559:Tacrolimus / Q000627:therapeutic use*; D014298:Trimethyltin Compounds
chemical_list: D000927:Anticonvulsants; D018690:Excitatory Amino Acid Agonists; D007166:Immunosuppressive Agents; D014298:Trimethyltin Compounds; C046488:trimethyltin; D007608:Kainic Acid; D016559:Tacrolimus