title: Movement-related cortical activation in familial Parkinson disease.
abstract: We sought to determine whether or not first-degree relatives of patients with familial Parkinson disease (FDRs) present impaired movement-related cortical activity. We studied 10 familial Parkinson disease subjects, 10 FDRs, and 10 controls and analyzed event-related mu desynchronization (ERD) and beta synchronization. Forty percent FDRs presented reduced premovement mu ERD latency, suggesting that premovement cortical activation is impaired in FDRs.
authors.affiliation: Department of Clinical Neurophysiology, Hospital R. Salengro, Regional University Hospital, Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Delval
authors.forename: L
authors.initials: L
authors.lastname: Defebvre
authors.forename: E
authors.initials: E
authors.lastname: Labyt
authors.forename: X
authors.initials: X
authors.lastname: Douay
authors.forename: J-L
authors.initials: JL
authors.lastname: Bourriez
authors.forename: N
authors.initials: N
authors.lastname: Waucquiez
authors.forename: P
authors.initials: P
authors.lastname: Derambure
authors.forename: A
authors.initials: A
authors.lastname: Destée
mesh_terms: D000368:Aged; D003344:Cortical Synchronization / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009069:Movement Disorders / Q000503:physiopathology*; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology