title: BOX elements modulate gene expression in Streptococcus pneumoniae: impact on the fine-tuning of competence development.
abstract: More than 100 BOX elements are randomly distributed in intergenic regions of the pneumococcal genome. Here we demonstrate that these elements can affect expression of neighboring genes and present evidence that they are mobile. Together, our findings show that BOX elements enhance genetic diversity and genomic plasticity in Streptococcus pneumoniae.
authors.affiliation: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway.
authors.forename: Eivind
authors.initials: E
authors.lastname: Knutsen
authors.forename: Ola
authors.initials: O
authors.lastname: Johnsborg
authors.forename: Yves
authors.initials: Y
authors.lastname: Quentin
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Claverys
authors.forename: Leiv Sigve
authors.initials: LS
authors.lastname: Håvarstein
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000235:genetics / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; C061262:ComA protein, Bacteria; C103179:ComE protein, Streptococcus pneumoniae; D004268:DNA-Binding Proteins