title: A case of alpha-thalassemia-2 associated with pulmonary infarction.
abstract: Pulmonary infarction is an entity of medical significance that develops concurrently in beta-thalassemia but not in alpha-thalassemia. The reason for this difference is yet to be elucidated. We have evaluated a 21-year-old male alpha-thalassemia-2 patient who had profound microcytic anemia and pulmonary infarction. Analysis of the alpha-globin gene revealed -alpha3.7/alpha alpha genotype. His mother also had the same heterozygous gene deletion, though she had neither anemia nor pulmonary infarction. Since the patient had no other predisposition to pulmonary infarction, it is suggested that there is a close etiologic relationship between morphologic abnormality of the erythrocytes caused by alpha-thalassemia-2 and development of pulmonary infarction.
authors.affiliation: Department of Medicine, NHO Kinki-Chuo Chest Medical Center, Sakai-city, Osaka, 591-8555, Japan. shayashi@kch.hosp.go.jp
authors.forename: Seiji
authors.initials: S
authors.lastname: Hayashi
authors.forename: Hiroto
authors.initials: H
authors.lastname: Matsuoka
authors.forename: Teruo
authors.initials: T
authors.lastname: Harano
authors.forename: Keiko
authors.initials: K
authors.lastname: Harano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakahara
authors.forename: Isao
authors.initials: I
authors.lastname: Tachibana
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kida
authors.forename: Tomio
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Shingo
authors.initials: S
authors.lastname: Kyotani
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Oka
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Sakatani
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawase
mesh_terms: D000328:Adult; D005914:Globins / Q000235:genetics; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000150:complications* / Q000235:genetics; D017085:alpha-Thalassemia / Q000150:complications* / Q000235:genetics
chemical_list: D005914:Globins