Synthesis of chlorambucil-tempol adduct and its delivery using fluoroalkyl double-ended poly (ethylene glycol) micelles.
In our pursuit to find potent anticancer drugs, we have covalently bonded free radical tempol to chlorambucil giving a chlorambucil-tempol (CT) adduct in which both of the anticancer active sites in tempol and chlorambucil were left intact. Analysis using NMR, Maldi-TOF, and EPR verified the designed chemical structure. Because the CT adduct is more hydrophobic than chlorambucil, its delivery also was investigated using fluoroalkyl double-ended poly (ethylene glycol) (Rf-PEG) micelles. Results from EPR spectra and(19) F and(1) H NMR spin lattice relaxation times show that the Rf-PEG micelles are able to encapsulate CT into the Rf cores of the micelles.
Prabhutendolkar
Anuja
A
Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Liu
Xiangli
X
Mathias
Errol V
EV
Ba
Yong
Y
Kornfield
Julie A
JA
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000737:chemistry*; D002699:Chlorambucil / Q000008:administration & dosage / Q000737:chemistry*; D003497:Cyclic N-Oxides / Q000737:chemistry*; D016503:Drug Delivery Systems; D004578:Electron Spin Resonance Spectroscopy; D005079:Excipients; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008970:Molecular Weight; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013113:Spin Labels
D018906:Antineoplastic Agents, Alkylating; D003497:Cyclic N-Oxides; D005079:Excipients; D006845:Hydrocarbons, Fluorinated; D008823:Micelles; D014677:Pharmaceutical Vehicles; D013113:Spin Labels; D002699:Chlorambucil; D011092:Polyethylene Glycols; C001803:tempol