title: Neo-aortic valvar function after the arterial switch.
abstract: OBJECTIVE
  The purpose of our study was to assess the prevalence and progression, during childhood and adolescence, of dilation of the neo-aortic root, and neo-aortic valvar regurgitation, and to identify risk factors for such dilation and regurgitation, after the arterial switch operation.
  
  
  METHODS
  We included all patients who had undergone an arterial switch operation at The Children's Hospital of Philadelphia, and had been followed for a minimum of 4 years, and had at least 2 postoperative echocardiograms. Neo-aortic valvar regurgitation was quantitatively assessed, and measurements were made of the neo-aortic root at the level of the basal attachment of the leaflets, mid-sinusal level, and the sinutubular junction.
  
  
  RESULTS
  We found 82 patients who satisfied the criterions for inclusion, of whom 52 patients had transposition with an intact ventricular septum, and 30 had either an associated ventricular septal defect or double outlet right ventricle. The median follow-up time was 8.8 years (4.1 to 16.4 years). The neo-aortic valve had been replaced in 1 patient. Of the patients, 3 had moderate, 66 had trivial to mild, and 12 had no neo-aortic valvar regurgitation at their most recent follow-up. The regurgitation had progressed by at least 1 grade in 38 of the 82 patients (46.4%). Neo-aortic dilation was noted at the basal attachment of the leaflets, and at mid-sinusal level, which was out of proportion to somatic growth.
  
  
  CONCLUSIONS
  At mid-term follow-up, significant neo-aortic valve regurgitation is present in 3.7%, and trivial to mild regurgitation in 81.4% of patients. The regurgitation progressed in almost half of the patients over time. We also noted progressive dilation of the neo-aortic root out of proportion to somatic growth.
authors.affiliation: Cardiac Center, Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, United States of America. marino@email.chop.edu
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Marino
authors.forename: Gil
authors.initials: G
authors.lastname: Wernovsky
authors.forename: Doff B
authors.initials: DB
authors.lastname: McElhinney
authors.forename: Abbas
authors.initials: A
authors.lastname: Jawad
authors.forename: Dieuwertje L
authors.initials: DL
authors.lastname: Kreb
authors.forename: Suzan F
authors.initials: SF
authors.lastname: Mantel
authors.forename: Wendy L
authors.initials: WL
authors.lastname: van der Woerd
authors.forename: Danielle
authors.initials: D
authors.lastname: Robbers-Visser
authors.forename: Rita
authors.initials: R
authors.lastname: Novello
authors.forename: J William
authors.initials: JW
authors.lastname: Gaynor
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Spray
authors.forename: Meryl S
authors.initials: MS
authors.lastname: Cohen
mesh_terms: D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D002675:Child, Preschool; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications; D012086:Reoperation; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D014188:Transposition of Great Vessels / Q000601:surgery*; D016896:Treatment Outcome