The molecular mechanisms of skeletal muscle wasting: implications for therapy.
Skeletal muscle wasting is an important systemic manifestation of a wide range of diseases, including trauma, sepsis and cancer. The clinical consequences of muscle wasting undoubtedly include significant patient morbidity and worsened survival. Recently, there has been important progress in our understanding of the molecular mechanisms behind muscle wasting. In this review, the common systemic mediators, intracellular signalling pathways and effector mechanisms of skeletal muscle wasting are discussed with particular reference to different models of wasting and the development of novel therapeutic strategies.
Skipworth
R J E
RJ
Clinical and Surgical Sciences (Surgery), School of Clinical Sciences and Community Health, The University of Edinburgh, Scotland, UK.
Stewart
G D
GD
Ross
J A
JA
Guttridge
D C
DC
Fearon
K C H
KC
D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D009140:Musculoskeletal Diseases / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D019282:Wasting Syndrome / Q000378:metabolism* / Q000503:physiopathology
D047908:Intracellular Signaling Peptides and Proteins; D009124:Muscle Proteins; D014157:Transcription Factors