title: Gelastic seizures involving the right parietal lobe.
abstract: Gelastic seizures have been described in various epilepsies arising from the temporal or frontal lobes, although the most commonly encountered form is related to the presence of an hypothalamic hamartoma. We report a patient with gelastic seizures involving the right parietal lobe. Our patient, a 32-year-old man, underwent video-EEG monitoring, interictal and ictal brain SPECTs during gelastic seizures. Subtraction ictal SPECT co-registered to MRI (SISCOM), was performed to localize any ictal hyperperfusion during these gelastic seizures. The seizures consisted of brief staring followed by smiling and laughing. Electroencephalography during the gelastic seizures showed rhythmic sharp waves in the right parietal lobe. SISCOM showed ictal hyperperfusion in the right parietal lobe and medial portions of right cerebellum. Our findings suggest that the right parietal lobe may actively participate in the particular epileptogenic network generating gelastic seizures.
authors.affiliation: Department of Neurology, Samsung Medical center, Sungkyunkwan University School of Medicine, Korea.
authors.forename: Hee-Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Seung Bong
authors.initials: SB
authors.lastname: Hong
authors.forename: Eun Yeon
authors.initials: EY
authors.lastname: Joo
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Tae
authors.forename: Sun Jung
authors.initials: SJ
authors.lastname: Han
authors.forename: Jae Wook
authors.initials: JW
authors.lastname: Cho
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Seo
authors.forename: Sun Hyung
authors.initials: SH
authors.lastname: Kim
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
mesh_terms: D000328:Adult; D000927:Anticonvulsants; D002529:Cerebellar Nuclei / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000927:Anticonvulsants