CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly.
BACKGROUND
The pathogenesis of increased blood pressure (BP) in acromegaly is unclear, and the role of IGF-I levels and the renin-angiotensin-aldosterone system (RAAS) in this disease remains controversial.


OBJECTIVE
The aim of this study was to investigate the role of gene polymorphisms of the RAAS and involved in sodium handling on BP in acromegaly.


METHODS
We conducted a multicentric retrospective study that included 100 consecutive patients with acromegaly referred during the period 2000-2003.


METHODS
All patients were genotyped for ACE I/D, AGT M235T, CYP11B2 -344T/C, B2R -58T/C, and alpha-adducin G460W polymorphisms.


METHODS
We assessed the prevalence of hypertension and BP according to the genotype.


RESULTS
Patients with the CYP11B2 -344CC genotype displayed a significant increase in the risk of hypertension compared with patients with CT/TT genotypes (odds ratio = 4.0; 95% confidence interval = 1.4-11.6; P = 0.01). Consistently, a significant proportion of patients with the CYP11B2 -344CC genotypes were under antihypertensive treatment (73.1%) compared with patients with the TT/TC genotypes (38.2%; P = 0.003). Patients with the -344CC genotype displayed a significant increase in systolic BP (10.2 +/- 4.3 mm Hg; P = 0.02) but not a significant increase in diastolic BP (2.6 +/- 2.6 mm Hg; P = 0.32) compared with patients with the CT/TT genotype.


CONCLUSIONS
We have shown an association of the -344T/C CYP11B2 gene polymorphism with BP in patients affected by acromegaly. These findings suggest that the RAAS is implicated in the pathogenesis of hypertension in acromegaly.
Mulatero
Paolo
P
Division of Internal Medicine, Hypertension Unit, Ospedale San Vito, Strada San Vito 34, 10133 Torino, Italy. paolo.mulatero@libero.it
Veglio
Franco
F
Maffei
Pietro
P
Bondanelli
Marta
M
Bovio
Silvia
S
Daffara
Fulvia
F
Leotta
Giannina
G
Angeli
Alberto
A
Calvo
Chiara
C
Martini
Chiara
C
degli Uberti
Ettore C
EC
Terzolo
Massimo
M
D000172:Acromegaly / Q000235:genetics* / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors
D019405:Cytochrome P-450 CYP11B2