Endophenotype approach to developmental psychopathology: implications for autism research.
This paper discusses the utility of the endophenotype approach in the study of developmental psychopathology. It is argued that endophenotype research holds considerable promise for the study of gene-brain/cognition-behaviour pathways for developmental disorders. This paper outlines the criteria for determining useful endophenotypes. Possible endophenotypes for autism are discussed as an example of an area where endophenotype research on developmental disorders may be fruitful. It is concluded that although the endophenotype approach holds promise for the study of gene-brain/cognition-behaviour pathways, much work remains to be done in order to validate endophenotype measures. It is also noted that the changing nature of any developmental psychopathology poses a particular challenge to this type of research.
Viding
Essi
E
Department of Psychology, University College London, Gower Street, London, WC1E 6BT, UK. e.viding@ucl.ac.uk
Blakemore
Sarah-Jayne
SJ
D000818:Animals; D001321:Autistic Disorder / Q000235:genetics / Q000523:psychology*; D035843:Biomedical Research; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype