title: Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolated from Mongolian patients with chronic HBV infection.
abstract: Although there is a report of a high rate of hepatitis B virus (HBV) infection in Mongolia, the entire nucleotide sequence of HBV circulating among Mongolian patients has not been reported. To obtain the complete nucleotide sequence of the Mongolian HBV, viral DNA was extracted from sera of patients with HBV infection. Six Mongolian HBV strains were amplified by PCR. Complete genomic sequences were determined for two Mongolian HBV isolates, MBT181 and MMU36. The entire genome of Mongolian HBV isolates was 3,182 bp long and genetic distance between Mongolian HBV isolates was 3.2%. Precore stop codon resulting from a guanine to adenine mutation at nucleotide 1,896 was detected in MBT181 strain. Based on phylogenetic analysis, the six Mongolian isolates were classified as genotype D.
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, 136-705, Korea.
authors.forename: Zagaa
authors.initials: Z
authors.lastname: Odgerel
authors.forename: In Keun
authors.initials: IK
authors.lastname: Choi
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Byun
authors.forename: Chin Yong
authors.initials: CY
authors.lastname: Pak
authors.forename: Shannon
authors.initials: S
authors.lastname: Bennett
authors.forename: Se-Hun
authors.initials: SH
authors.lastname: Gu
authors.forename: Kwangsook
authors.initials: K
authors.lastname: Park
authors.forename: Sun Ho
authors.initials: SH
authors.lastname: Kee
authors.forename: Ki-Joon
authors.initials: KJ
authors.lastname: Song
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Song
mesh_terms: D019943:Amino Acid Substitution; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D016679:Genome, Viral; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000821:virology*; D006801:Humans; D008986:Mongolia; D010802:Phylogeny; D014764:Viral Proteins / Q000235:genetics
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins