Hypoglycaemia secondary to the secretion of pro-insulin like growth factor II by a metastatic neuroendocrine tumour with sarcomatous differentiation.
A patient presented with frequent episodes of spontaneous hypoglycaemia due to a disseminated neuroendocrine tumour with sarcomatous differentiation, secreting incompletely processed pro-insulin-like growth factor II (pro-IGF-II). Although the combination of GH and glucocorticoid therapy initially controlled the hypoglycaemia, there was a later escape necessitating frequent re-admissions to hospital. The patient deceased two weeks following her latest admission.
Morgan
Mia
M
Department of Endocrinology, St Bartholomew's Hospital, London EC1A 7BE, UK.
Nanzer
Alexandra
A
Camacho-Hubner
Cecilia
C
Kaltsas
Gregory A
GA
Monson
John P
JP