Association between A/C1166 gene polymorphism of the angiotensin II type 1 receptor and biventricular functions in patients with acute myocardial infarction.
BACKGROUND
Although there have been several association studies of angiotensin II type 1 receptor (AT1R, A/C1166) gene polymorphism in clinical endpoints such as myocardial infarction (MI), hypertension, aortic stiffness, and left ventricular mass, the relationship between AT1R polymorphism and biventricular function in acute anterior MI has not been studied before.


RESULTS
The study group comprised 132 consecutive patients who were admitted to the coronary care unit with their first acute anterior MI. Systolic and diastolic diameters, volumes, inflow properties, ejection fraction and myocardial performance index of both ventricles were measured. AT1R polymorphism was determined using polymerase chain reaction amplification. Based on A/C1166 polymorphism of AT1R, the patients were classified into 3 groups: group 1, A/A (n=91) genotype, group 2 A/C (n=28), and group 3 C/C (n=13) genotype. When the left ventricular and right ventricular echocardiographic functions were compared, all parameters of the 3 groups were found to be similar. No difference was detected in either the genotype distribution or allele frequencies between the patients and the controls for AT1R.


CONCLUSIONS
The results suggest that A/C1166 polymorphism of AT1R did not influence the risk of either acute MI or biventricular function after anterior MI.
Ulgen
Mehmet S
MS
Meram School of Medicine, Department of Cardiology, Selcuk University Hospital, Konya, Turkey. msulgen@hotmail.com
Ozturk
Onder
O
Yazici
Mehmet
M
Kayrak
Mehmet
M
Alan
Sait
S
Koç
Fatih
F
Tekes
Selahattin
S
D000368:Aged; D004562:Electrocardiography; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000502:physiology*; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*; D016276:Ventricular Function / Q000235:genetics*
D044139:Receptor, Angiotensin, Type 2