title: Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base.
abstract: We synthesized various 3-methyl-1-phenyl-5-pyrazolone (edaravone) derivatives and evaluated their oxidation potential and hydroxyl radical scavenging activity. It was found 3-methyl-1-(pyridin-2-yl)-5-pyrazolone had a much higher ability to scavenge the radical than did edaravone itself. Its efficient radical scavenging activity was assumed to be due to the increase of its anion form, an active form, by a hydrogen-bonded intramolecular base.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. deco@phar.nagoya-cu.ac.jp <deco@phar.nagoya-cu.ac.jp>
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Ryo
authors.initials: R
authors.lastname: Ohyama
authors.forename: Ayako
authors.initials: A
authors.lastname: Kimata
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyata
mesh_terms: D000983:Antipyrine / Q000031:analogs & derivatives* / Q000737:chemistry; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D047069:Pyrazolones / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: C515884:3-methyl-1-(pyridin-2-yl)-5-pyrazolone; D016166:Free Radical Scavengers; D047069:Pyrazolones; D011725:Pyridines; D017665:Hydroxyl Radical; D000077553:Edaravone; D000983:Antipyrine