Coxsackievirus B3 in human milk.
Coxsackievirus B3 can cause severe neonatal disease with high mortality. We present the first report of detection of coxsackievirus B3 in the mothers' milk of 2 severely infected neonates by culture and reverse transcriptase-polymerase chain reaction. Reverse transcriptase-polymerase chain reaction is a rapid and sensitive tool to detect coxsackievirus B3 in breast milk within few hours. By 12 to 14 days after onset of symptoms, coxsackievirus B3 could not be detected in the breast milk of the symptomatic mothers.
Chang
Mei-Ling
ML
Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Tiawan.
Tsao
Kuo-Chien
KC
Huang
Chi-Chia
CC
Yen
Meng-Hsiu
MH
Huang
Chung-Guei
CG
Lin
Tzou-Yien
TY
D000328:Adult; D003384:Coxsackievirus Infections / Q000821:virology*; D029822:Enterovirus B, Human / Q000254:growth & development / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000821:virology*; D009035:Mothers; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D019562:Viral Load
D012367:RNA, Viral