title: Synthesis of omega-(hetero)arylalkynylated alpha-amino acid by Sonogashira-type reactions in aqueous media.
abstract: Mild conditions are described that allow the palladium-catalyzed cross-coupling of C(alpha)-alkynylated glycine with a wide variety of electron-rich and electron-poor aryl and heteroaryl halides in aqueous media.
authors.affiliation: Departamento de Química Organica e Unidade Asociada ó C.S.I.C., Facultade de Química, Universidade de Santiago, 15782 Santiago de Compostela, Spain.
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Brea
authors.forename: M Pilar
authors.initials: MP
authors.lastname: López-Deber
authors.forename: Luis
authors.initials: L
authors.lastname: Castedo
authors.forename: Juan R
authors.initials: JR
authors.lastname: Granja
mesh_terms: D000480:Alkynes / Q000737:chemistry; D024322:Amino Acids, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005998:Glycine / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D012996:Solutions; D014867:Water
chemical_list: D000480:Alkynes; D024322:Amino Acids, Aromatic; D006846:Hydrocarbons, Halogenated; D012996:Solutions; D014867:Water; D010165:Palladium; D005998:Glycine