Two new scorpionates vanadium haloperoxidases model complexes: synthesis and structure of VO(O2)(pzH)(HB(pz)3) and VO(O2)(pzH)(B(pz)4) (pzH = pyrazole(C3H4N2)).
Using vanadate, poly(1H-pyrazol-1-yl)borate and pyrazole as starting materials, two new neutral peroxovanadium(V) complexes with poly(1H-pyrazol-1-yl)borate, VO(O(2))(pzH)(HB(pz)(3))(1) and VO(O(2))(pzH)(B(pz)(4))(2), were synthesized successfully. Both complexes were characterized by elemental analysis, IR, UV-vis and NMR spectra. And the structure of complex 1 was determined by X-ray diffraction, which is somewhat relevant for haloperoxidase enzymes. Cytotoxic effects also are discussed on 3T3 cell proliferation. In the concentration range (0.1-100mumol), both complexes have an inhibiting cellular proliferation effect. When the cells cultivated with the complexes at high dose, the toxicity effect of both complexes is more and more predominant.
Xing
Yongheng
Y
Bioinorganic Laboratory, Liaoning Normal University, Dalian 116029, PR China. yhxing2000@yahoo.com
Zhang
Yuanhong
Y
Sun
Zheng
Z
Ye
Ling
L
Xu
Yongting
Y
Ge
Maofa
M
Zhang
Baoli
B
Niu
Shuyun
S
D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010544:Peroxidases / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017968:Vanadium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014961:X-Ray Diffraction
D011720:Pyrazoles; D017968:Vanadium Compounds; D010544:Peroxidases