Surface adhesins of Staphylococcus aureus.
An important facet in the interaction between Staphylococcus aureus and its host is the ability of the bacterium to adhere to human extracellular matrix components and serum proteins. In order to colonise the host and disseminate, it uses a wide range of strategies, the molecular and genetic basis of which are multifactorial, with extensive functional overlap between adhesins. Here, we describe the current knowledge of the molecular features of the adhesive components of S. aureus, mechanisms of adhesion and the impact that these have on host-pathogen interaction.
Clarke
Simon R
SR
Department of Molecular Biology & Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
Foster
Simon J
SJ
D018829:Adhesins, Bacterial / Q000502:physiology*; D020816:Amino Acid Motifs; D000818:Animals; D001422:Bacterial Adhesion / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000502:physiology*
D018829:Adhesins, Bacterial; C509820:MSCRAMM proteins, Staphylococcus