title: Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules.
abstract: Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.
authors.affiliation: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, USA.
authors.forename: Tonya J Roberts
authors.initials: TJ
authors.lastname: Webb
authors.forename: Roberta A
authors.initials: RA
authors.lastname: Litavecz
authors.forename: Masood A
authors.initials: MA
authors.lastname: Khan
authors.forename: Wenjun
authors.initials: W
authors.lastname: Du
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: Gervay-Hague
authors.forename: Gourapura J
authors.initials: GJ
authors.lastname: Renukaradhya
authors.forename: Randy R
authors.initials: RR
authors.lastname: Brutkiewicz
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology*; D055610:Antigens, CD1d; D015153:Blotting, Western; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology*; D005434:Flow Cytometry; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D009154:Mutation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014616:Vaccinia virus / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; D004268:DNA-Binding Proteins; C091945:H5R protein, Vaccinia virus; C074058:VB1R protein, Vaccinia virus; D014764:Viral Proteins; D020929:Mitogen-Activated Protein Kinase Kinases