Report of two cases of aseptic meningitis with persistence of pneumococcal cell wall components in cerebrospinal fluid after Pneumococcal meningitis.
We describe two cases of aseptic meningitis occurring some time after pneumococcal meningitis. Both cases may have resulted from an inflammatory response to persistent pneumococcal cell membrane components, as the cerebrospinal fluid samples were positive by the Binax NOW Streptococcus pneumoniae antigen test. Potential mechanisms and diagnostic impact are discussed.
Angoulvant
François
F
Service de Pédiatrie Générale, Hôpital Robert Debré, 48 Boulevard Sérurier, 75019 Paris, France. francois.angoulvant@rdb.aphp.fr
Lachenaud
Julie
J
Mariani-Kurkdjian
Patricia
P
Aubertin
Guillaume
G
Houdouin
Véronique
V
Lorrot
Mathie
M
de Los Angeles
Laure
L
Bingen
Edouard
E
Bourrillon
Antoine
A
Faye
Albert
A
D000942:Antigens, Bacterial / Q000134:cerebrospinal fluid*; D002473:Cell Wall / Q000737:chemistry; D005260:Female; D006801:Humans; D007223:Infant; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid / Q000382:microbiology*; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid / Q000382:microbiology*; D011135:Polysaccharides, Bacterial / Q000134:cerebrospinal fluid*
D000942:Antigens, Bacterial; D011135:Polysaccharides, Bacterial; C027158:polysaccharide C-substance (Streptococcus)