[Comparison of CD15, galectin-3 and HBME-1 expression in follicular thyroid neoplasms].
BACKGROUND
Estimation of malignancy in thyroid follicular neoplasms is a common diagnostic problem, thus revealing of differences in expression of some antigens in both benign and malignant lesions seems to be essential. The aim of this study is to evaluate the immunohistochemical expression of CD15, galectin-3 and HBME-1 in follicular adenomas and carcinomas.


METHODS
Samples of 38 follicular adenomas (23 "classical", 5 with intracapsular invasion, 10 oncocytic) and 15 follicular carcinomas (9 "classic", 6 oncocytic) were stained immunohistochemically with anti-CD15, galectin-3 and HBME-1.


RESULTS
In the whole group we found statistically significant differences in CD15 expression between follicular adenomas and carcinomas. "Classic" follicular carcinomas (without oncocytic tumors) showed stronger CD15 and HBME- 1 expression than "classic" adenomas. Adenomas with intracapsular invasion differed from "classic" adenomas only in HBME-1 expression. In oncocytic tumors the expression of examined antigens was similar.


CONCLUSIONS
1. In the group of nonoxyphilic tumors positive reaction with HBME-1 was more common in adenomas with intracapsular invasion and carcinomas, but positive reaction with anti-CD15--only in carcinomas. We suggest that reactivity with these antibodies could mark malignancy. 2. Oncocytic tumors had similar expression of CD15 and HBME-1 and galectin-3.
Bogdańska
Magdalena
M
Department of Pathological Anatomy, Warsaw Medical University, Warszawa.
Górnicka
Barbara
B
Ziarkiewicz-Wróblewska
Bogna
B
Koperski
Lukasz
L
Morton
Marcin
M
Wasiutyński
Aleksander
A
D000236:Adenoma / Q000737:chemistry* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D018265:Carcinoma, Papillary, Follicular / Q000737:chemistry* / Q000473:pathology; D003937:Diagnosis, Differential; D037502:Galectin 3 / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D016256:Lewis X Antigen / Q000032:analysis*; D009361:Neoplasm Invasiveness; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000473:pathology; D000951:Antigens, Neoplasm
D014408:Biomarkers, Tumor; D037502:Galectin 3; D016256:Lewis X Antigen; C432845:HBME-1 antigen; D000951:Antigens, Neoplasm