Acute myelogenous leukemia associated with Ollier disease.
Ollier disease is a rare disorder characterized by the presence of multiple enchondromas and a propensity to develop malignancies. We report the case of a 7-year-old Caucasian male with Ollier disease who developed acute myelogenous leukemia (AML). This report describes a patient with Ollier disease and AML and may offer a clue into the genetic pathogenesis of these disorders.
White
Matthew S
MS
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Martin
Paul L
PL
McLean
Thomas W
TW
D000617:Aminoglycosides / Q000008:administration & dosage; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002883:Chromosomes, Human, Pair 14 / Q000648:ultrastructure; D002891:Chromosomes, Human, Pair 21 / Q000648:ultrastructure; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D004687:Enchondromatosis / Q000235:genetics*; D005047:Etoposide / Q000008:administration & dosage; D000079982:Gemtuzumab; D006086:Graft vs Host Disease; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000601:surgery; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D014178:Translocation, Genetic
D000617:Aminoglycosides; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D003561:Cytarabine; D005047:Etoposide; D000079982:Gemtuzumab; D008942:Mitoxantrone; D003630:Daunorubicin