Urinary bactericidal activity of extended-release ciprofloxacin (1,000 milligrams) versus levofloxacin (500 milligrams) in healthy volunteers receiving a single oral dose.
Twelve volunteers received a single oral dose of 1,000 mg extended-release (XR) ciprofloxacin versus 500 mg levofloxacin to assess urinary bactericidal titers (UBTs) against common uropathogens. Areas under UBT-time curves were significantly larger for Proteus mirabilis with XR ciprofloxacin and for staphylococci with levofloxacin.
Wagenlehner
Florian M E
FM
Department of Urology, Hospital St. Elisabeth, St. Elisabeth Str. 23, D-94315 Straubing, Germany. Wagenlehner@AOL.com
Kinzig-Schippers
Martina
M
Tischmeyer
Uwe
U
Wagenlehner
Christine
C
Sörgel
Fritz
F
Naber
Kurt G
KG
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019540:Area Under Curve; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000494:pharmacology*; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations; D006801:Humans; D064704:Levofloxacin; D015242:Ofloxacin / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects*; D013210:Staphylococcus / Q000187:drug effects; D014556:Urine / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D002939:Ciprofloxacin; D064704:Levofloxacin; D015242:Ofloxacin