title: Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.
abstract: Novel tetrahydroisoquinolines have been developed as potent PPAR ligands. Evaluation of these compounds in PPARgamma responsive models of type 2 diabetes is described.
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. jrhenry@lilly.com
authors.forename: James R
authors.initials: JR
authors.lastname: Henry
authors.forename: Yihong
authors.initials: Y
authors.lastname: Li
authors.forename: Alan M
authors.initials: AM
authors.lastname: Warshawsky
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Brozinick
authors.forename: Eric D
authors.initials: ED
authors.lastname: Hawkins
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Misener
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Briere
authors.forename: Chahrzad
authors.initials: C
authors.lastname: Montrose-Rafizadeh
authors.forename: Richard W
authors.initials: RW
authors.lastname: Zink
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Yumibe
authors.forename: Rose T
authors.initials: RT
authors.lastname: Ajamie
authors.forename: Brad
authors.initials: B
authors.lastname: Wilken
authors.forename: Viswanath
authors.initials: V
authors.lastname: Devanarayan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D047495:PPAR gamma / Q000819:agonists* / Q000187:drug effects; D047492:Peroxisome Proliferator-Activated Receptors / Q000037:antagonists & inhibitors; D000077154:Rosiglitazone; D044005:Tetrahydroisoquinolines / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D045162:Thiazolidinediones / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D047495:PPAR gamma; D047492:Peroxisome Proliferator-Activated Receptors; D044005:Tetrahydroisoquinolines; D045162:Thiazolidinediones; D000077154:Rosiglitazone