Maribavir antagonizes the antiviral action of ganciclovir on human cytomegalovirus.
The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir antagonized the anti-CMV effect of ganciclovir, increasing the ganciclovir 50% inhibitory concentration against a sensitive strain by up to 13-fold. Antiviral activities of foscarnet and cidofovir were unaffected by maribavir.
Chou
Sunwen
S
Medical and Research Services, VA Medical Center, Oregon Health & Science University, Portland, OR 97239, USA. chous@ohsu.edu
Marousek
Gail I
GI
D000998:Antiviral Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000821:virology; D004336:Drug Antagonism; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D015774:Ganciclovir / Q000037:antagonists & inhibitors*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012263:Ribonucleosides / Q000494:pharmacology*; D004004:Dichlororibofuranosylbenzimidazole / Q000031:analogs & derivatives
D000998:Antiviral Agents; D001562:Benzimidazoles; D015774:Ganciclovir; D012263:Ribonucleosides; C400401:maribavir; D004004:Dichlororibofuranosylbenzimidazole