The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA).
Several groups have demonstrated an association between established CHD and elevated oxidized LDL (oxLDL). The relation with cardiovascular risk factors and subclinical CVD is less clear. Therefore, we examined this association in the Multi-Ethnic Study of Atherosclerosis cohort: 879 persons without CHD, all non-statin users, examined cross-sectionally. oxLDL was measured with a monoclonal antibody 4E6-based ELISA. The presence of subclinical CVD was defined as plaque occurrence in carotid arteries with > or = 25 stenosis, ankle-brachial blood pressure index (ABI) < 0.9 and coronary calcification based on Agatston calcium score > or = 200. In a multivariate model, dyslipidemia (adverse levels of cholesterol, HDL-cholesterol, triglycerides), inflammation (elevated fibrinogen), gender (male), ethnicity (Black), and current smoking explained the most variation in oxLDL (model R2=0.41). In bivariate analyses, persons with subclinical CVD had higher levels of oxLDL (1.22 mg/dl versus 0.95 mg/dl; P=0.0002). Adjustment for risk factor correlates attenuated associations with subclinical CVD (P=0.026). In conclusion, oxLDL is associated with subclinical CVD by its relationship with many cardiovascular risk factors.
Holvoet
Paul
P
Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium. paul.holvoet@med.kuleuven.be
Jenny
Nancy S
NS
Schreiner
Pamela J
PJ
Tracy
Russell P
RP
Jacobs
David R
DR
D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data; D050197:Atherosclerosis / Q000097:blood* / Q000208:ethnology*; D044383:Black People / Q000706:statistics & numerical data; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D015995:Prevalence; D044469:Racial Groups / Q000706:statistics & numerical data*; D012307:Risk Factors; D044465:White People / Q000706:statistics & numerical data
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein