title: Store-operated Ca2+ entry: A STIMulating stOrai.
abstract: Store-operated Ca2+ entry (SOCE) mediates much of the Ca2+ entry evoked by receptors that stimulate phospholipase C. However, for 20 years, the plasma membrane Ca2+ channel and the signal linking its activation to loss of Ca2+ from the endoplasmic reticulum (ER) have eluded detection. But the search might now be over. Two proteins, STIM1 (the ER Ca2+ sensor) and Orai1 (the Ca2+ channel), have recently been identified as the missing links in SOCE.
authors.affiliation: Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK. cwt1000@cam.ac.uk
authors.forename: Colin W
authors.initials: CW
authors.lastname: Taylor
mesh_terms: D002118:Calcium / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D017136:Ion Transport
chemical_list: D002118:Calcium