Synthesis and anti-tumor activities of novel pyrazolo[1,5-a]pyrimidines.
A series of novel pyrazolo[1,5-a]pyrimidines were designed and synthesized in order to find novel potent anti-tumor compounds. The structures of all the compounds were confirmed by IR, (1)H-NMR, elemental analysis, and MS. Their anti-tumor activities against cancer cell lines were tested by the MTT method in vitro. Compound 19 displayed potent anti-tumor activity.
Li
Juan
J
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Zhao
Yan Fang
YF
Zhao
Xiang Lin
XL
Yuan
Xiao Ye
XY
Gong
Ping
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011720:Pyrazoles; D011743:Pyrimidines