title: Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry.
abstract: BACKGROUND
  Accurate characterization of asthma severity is difficult due to the variability of symptoms. Hyperpolarized helium-3 MRI (H(3)HeMR) is a new technique in which the airspaces are visualized, depicting regions with airflow obstruction as "ventilation defects." The objective of this study was to compare the extent of H(3)HeMR ventilation defects with measures of asthma severity and spirometry.
  
  
  METHODS
  Patients with a physician diagnosis of asthma and normal control subjects underwent H(3)HeMR. For each person, the number and size of ventilation defects were scored and the average number of ventilation defects per slice (VDS) was calculated. The correlations of the imaging findings with measures of asthma severity and spirometry were determined.
  
  
  RESULTS
  There were 58 patients with asthma (mild-intermittent, n = 13; mild-persistent, n = 13; moderate-persistent, n = 20; and severe-persistent, n = 12) and 18 control subjects. Mean +/- SE VDS for asthmatics was significantly greater than for control subjects (0.99 +/- 0.15 vs 0.26 +/- 0.22, p = 0.004). Among asthmatics, VDS was significantly higher for the group with moderate-persistent and severe-persistent disease than for the group with mild-intermittent and mild-persistent disease (1.37 +/- 0.24 vs 0.53 +/- 0.12, p < 0.001). VDS correlated significantly with FEV(1)/FVC (r = - 0.51, p = 0.002), forced expiratory flow between 25% and 75% from the beginning of FVC (FEF(25-75%)) percentage of predicted for height, sex, and race (%predicted) [r = - 0.50, p = 0.001], and FEV(1) %predicted (r = - 0.40, p = 0.002), but not with FVC %predicted (r = - 0.26, p = 0.057) and peak expiratory flow %predicted (r = - 0.16, p = 0.231). Many asthmatics had an elevated VDS, but their spirometric indexes, except FEF(25%-75%), were normal. Most ventilation defects were < 3 cm in size for all asthmatics. In the group of patients with moderate-to-severe persistent asthma, there were more defects > or =3 cm than in the group with mild-intermittent and mild-persistent disease (p = 0.021).
  
  
  CONCLUSIONS
  Regional changes of airflow obstruction in asthmatics depicted by H(3)HeMR correlate with measures of asthma severity and spirometry.
authors.affiliation: University of Virginia Health Sciences System, Department of Radiology, HSC 800170, Charlottesville, VA 22908, USA. delange@virginia.edu
authors.forename: Eduard E
authors.initials: EE
authors.lastname: de Lange
authors.forename: Talissa A
authors.initials: TA
authors.lastname: Altes
authors.forename: James T
authors.initials: JT
authors.lastname: Patrie
authors.forename: John D
authors.initials: JD
authors.lastname: Gaare
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Knake
authors.forename: John P
authors.initials: JP
authors.lastname: Mugler
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Platts-Mills
mesh_terms: D000293:Adolescent; D000328:Adult; D000402:Airway Obstruction / Q000175:diagnosis*; D001249:Asthma / Q000145:classification / Q000175:diagnosis*; D005541:Forced Expiratory Volume / Q000502:physiology; D006371:Helium; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007554:Isotopes; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008450:Maximal Midexpiratory Flow Rate / Q000502:physiology; D013147:Spirometry; D013223:Statistics as Topic; D014797:Vital Capacity / Q000502:physiology
chemical_list: D007554:Isotopes; D006371:Helium