Molecular basis of resistance displayed by highly ciprofloxacin-resistant Salmonella enterica serovar Typhi in Bangladesh.
Highly ciprofloxacin-resistant (MIC, 512 microg/ml) strains of Salmonella enterica serovar Typhi were isolated from the blood of typhoid patients in Dhaka, Bangladesh. The strains were indistinguishable by their antibiograms, biotypes, and variable-number tandem repeat types and had matching point mutations at positions 83 and 87 of the gyrA gene. The isolation of these strains in an area of high endemicity indicates the need for continuous surveillance of antibiotic resistance of S. enterica serovar Typhi and for the rationalized use of ciprofloxacin.
Saha
Samir K
SK
Department of Microbiology, Bangladesh Institute of Child Health, Dhaka Shishu (Children) Hospital, Dhaka 1207, Bangladesh. sksaha@bangla.net
Darmstadt
Gary L
GL
Baqui
Abdullah H
AH
Crook
Derrick W
DW
Islam
M Nurul
MN
Islam
Maksuda
M
Hossain
Maqsud
M
El Arifeen
Shams
S
Santosham
Mathuram
M
Black
Robert E
RE
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001459:Bangladesh / Q000453:epidemiology; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D012485:Salmonella typhi / Q000187:drug effects* / Q000302:isolation & purification; D014435:Typhoid Fever / Q000453:epidemiology / Q000382:microbiology
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin