[New molecular markers within the chronic myeloproliferative disorders. I: the PRV-1 gene].
PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having "masked" PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.
Larsen
Thomas Stauffer
TS
Odense Universitetshospital, Patologisk Institut og Haematologisk Afdeling X. thomas.stauffer.larsen@ouh.fyns-amt.dk
Pallisgaard
Niels
N
Christensen
Jacob Haaber
JH
Gram-Hansen
Paul
P
Kerndrup
Gitte B
GB
Møller
Michael Boe
MB
Hasselbalch
Hans Carl
HC
D015415:Biomarkers / Q000097:blood*; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D058851:GPI-Linked Proteins; D015870:Gene Expression; D006801:Humans; D007519:Isoantigens / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics*; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D010677:Philadelphia Chromosome; D011087:Polycythemia Vera / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D055728:Primary Myelofibrosis / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000235:genetics*; D013922:Thrombocytosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics
D015415:Biomarkers; C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D007519:Isoantigens; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface