Results from the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) trial on atrial flutter, a multicentric prospective randomized study comparing amiodarone and radiofrequency ablation after the first episode of symptomatic atrial flutter.
BACKGROUND
There is no published randomized study comparing amiodarone therapy and radiofrequency catheter ablation (RFA) after only 1 episode of symptomatic atrial flutter (AFL). The aim of the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) Trial of Atrial Flutter was 2-fold: (1) to prospectively compare first-line RFA (group I) versus cardioversion and amiodarone therapy (group II) after only 1 AFL episode; and (2) to determine the impact of both treatments on the long-term risk of subsequent atrial fibrillation (AF).


RESULTS
From October 2002 to February 2006, 104 patients (aged 78+/-5 years; 20 women) with AFL were included, with 52 patients in group I and 52 patients in group II. The cumulative risk of AFL or AF was interpreted with the use of Kaplan-Meier curves and compared by the log-rank test. Clinical presentation, echocardiographic data, and follow-up were as follows: age (78.5+/-5 versus 78+/-5 years), history of AF (27% versus 21.6%); structural heart disease (58% versus 65%), left ventricular ejection fraction (56+/-14% versus 54.5+/-14%), left atrial size (43+/-7 versus 43+/-6 mm), mean follow-up (13+/-6 versus 13+/-6 months; P=NS), recurrence of AFL (3.8% versus 29.5%; P<0.0001), and occurrence of significant AF beyond 10 minutes (25% versus 18%; P=0.3). Five complications (10%) were noted in group II (sick sinus syndrome in 2, hyperthyroidism in 1, and hypothyroidism in 2) and none in group I (0%) (P=0.03).


CONCLUSIONS
RFA should be considered a first-line therapy even after the first episode of symptomatic AFL. There is a better long-term success rate, the same risk of subsequent AF, and fewer secondary effects.
Da Costa
Antoine
A
Division of Cardiology, University Jean Monnet in Saint-Etienne, Saint-Etienne, France. dakosta@aol.com
Thévenin
Jérôme
J
Roche
Frédéric
F
Romeyer-Bouchard
Cécile
C
Abdellaoui
Loucif
L
Messier
Marc
M
Denis
Lucien
L
Faure
Emmanuel
E
Gonthier
Régis
R
Kruszynski
Georges
G
Pages
J Marie
JM
Bonijoly
Serge
S
Lamaison
Dominique
D
Defaye
Pascal
P
Barthélemy
J Claude
JC
Gouttard
Thierry
T
Isaaz
Karl
K
D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000627:therapeutic use*; D001282:Atrial Flutter / Q000188:drug therapy* / Q000453:epidemiology / Q000601:surgery*; D017115:Catheter Ablation; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome
D000638:Amiodarone