title: Hernia disease and collagen gene regulation: are there clues for intervention?
abstract: Collagens belong to the most abundant proteins in the body. After tissue injury, a coordinated regulation of collagen gene expression guides the formation of a provisional matrix that subsequently evolves into a mature scar with tensile strength. In the following, knowledge regarding collagen gene regulation that may provide insight into how to specifically address the biological problem of soft tissue weakness and recurrent hernia disease is summarized.
authors.affiliation: Interdisciplinary Center for Clinical Research BIOMAT, University Hospital, RWTH Aachen, Pauwelsstrasse 30, Aachen 52074, Germany. plynen@ukaachen.de
authors.forename: Petra
authors.initials: P
authors.lastname: Lynen Jansen
authors.forename: Uwe
authors.initials: U
authors.lastname: Klinge
authors.forename: Peter R
authors.initials: PR
authors.lastname: Mertens
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005786:Gene Expression Regulation; D006547:Hernia / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D014945:Wound Healing
chemical_list: D003094:Collagen; D004247:DNA