title: Agrobacterium tumefaciens soxR is involved in superoxide stress protection and also directly regulates superoxide-inducible expression of itself and a target gene.
abstract: Inactivation of Agrobacterium tumefaciens soxR increases sensitivity to superoxide generators. soxR expression is highly induced by superoxide stress and is autoregulated. SoxR also directly regulates the superoxide-inducible expression of atu5152. Taken together, the physiological role of soxR and the mechanism by which it regulates expression of target genes make the A. tumefaciens SoxR system different from other bacterial systems.
authors.affiliation: Laboratory of Biotechnology, Chulabhorn Research Institute, Lak Si, Bangkok 10210, Thailand.
authors.forename: Warawan
authors.initials: W
authors.lastname: Eiamphungporn
authors.forename: Nisanart
authors.initials: N
authors.lastname: Charoenlap
authors.forename: Paiboon
authors.initials: P
authors.lastname: Vattanaviboon
authors.forename: Skorn
authors.initials: S
authors.lastname: Mongkolsuk
mesh_terms: D016960:Agrobacterium tumefaciens / Q000187:drug effects / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D015964:Gene Expression Regulation, Bacterial; D018869:Heat-Shock Response; D008969:Molecular Sequence Data; D009154:Mutation; D011401:Promoter Regions, Genetic; D013481:Superoxides / Q000494:pharmacology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D014157:Transcription Factors; D013481:Superoxides; C070724:SoxR protein, Bacteria