title: Imatinib mesylate-induced acute hepatitis with autoimmune features.
abstract: Autoimmune hepatitis is a disorder of unknown aetiology. Imatinib belongs to a new class of anticancer agents with high selectivity toward a specific molecular target. Its main indications are chronic myeloid leukaemia and gastrointestinal tumours. We report here, for the first time to our knowledge, imatinib mesylate-induced hepatitis with autoimmune features.
authors.affiliation: Hepatogastroenterology, Bicêtre Hospital, LeKremlin Bicêtre, France. Valerie.dhalluin@bct.ap-hop-paris.fr
authors.forename: Valérie
authors.initials: V
authors.lastname: Dhalluin-Venier
authors.forename: Caroline
authors.initials: C
authors.lastname: Besson
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dimet
authors.forename: Anne
authors.initials: A
authors.lastname: Thirot-Bibault
authors.forename: Gilbert
authors.initials: G
authors.lastname: Tchernia
authors.forename: Catherine
authors.initials: C
authors.lastname: Buffet
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000998:Antiviral Agents / Q000627:therapeutic use; D001549:Benzamides; D004359:Drug Therapy, Combination; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D000068877:Imatinib Mesylate; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D008111:Liver Function Tests; D010879:Piperazines / Q000009:adverse effects*; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011743:Pyrimidines / Q000009:adverse effects*; D011994:Recombinant Proteins
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001549:Benzamides; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010879:Piperazines; D011743:Pyrimidines; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D000068877:Imatinib Mesylate; C100416:peginterferon alfa-2a; D011241:Prednisone