Regulation of TRP channels by PIP(2).
Transient receptor potential (TRP) channels are regulated by a wide variety of physical and chemical factors. Recently, several members of the TRP channel family were reported to be regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2), PIP(2)). This review will summarize the current knowledge on PIP(2) regulation of TRP channels and discuss the possibility that PIP(2) is a common regulator of mammalian TRP channels.
Rohacs
Tibor
T
Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103, USA. tibor.rohacs@umdnj.edu
D000818:Animals; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism*; D050052:TRPC Cation Channels / Q000737:chemistry / Q000378:metabolism*
D019269:Phosphatidylinositol 4,5-Diphosphate; D050052:TRPC Cation Channels