title: Improving prediction of aerosol deposition in an idealized mouth using large-Eddy simulation.
abstract: Monodisperse aerosol deposition in an idealized mouth geometry with a relatively small inlet diameter (D (in) = 3.0 mm) was studied numerically using a standard Large Eddy Simulation (LES). A steady inhalation flow rate of Q = 32.2 L/min was used. Thousands of particles (2.5, 3.7, and 5.0 microm in diameter and rho (f) = 912.0 kg/m(3) density) were released separately in the computational domain and aerosol deposition was determined. The total aerosol deposition results in this idealized mouth were in relatively good agreement when compared with measured data obtained in separate experiments, showing considerable improvement over the standard RANS/EIM (Reynolds Averaged Navier-Stokes/Eddy Interaction Model) approach.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Carleton University, Ottawa, ON, Canada. edgar.matida@mae.carleton.ca
authors.forename: Edgar A
authors.initials: EA
authors.lastname: Matida
authors.forename: Warren H
authors.initials: WH
authors.lastname: Finlay
authors.forename: Michael
authors.initials: M
authors.lastname: Breuer
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Lange
mesh_terms: D000336:Aerosols; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D015233:Models, Statistical; D008962:Models, Theoretical; D009055:Mouth / Q000033:anatomy & histology* / Q000187:drug effects; D009068:Movement; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012984:Software
chemical_list: D000336:Aerosols; D004364:Pharmaceutical Preparations