title: Randomized controlled trials of physical activity and breast cancer prevention.
abstract: Observational studies demonstrate that women who exercise have a lower risk of developing breast cancer compared with sedentary women, but clinical trials are necessary to demonstrate a decreased effect of exercise on breast cancer. This review presents a rationale for randomized controlled exercise trials for breast cancer prevention and proposes a construct for designing such trials.
authors.affiliation: Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA. melinda.irwin@yale.edu
authors.forename: Melinda L
authors.initials: ML
authors.lastname: Irwin
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D015444:Exercise / Q000502:physiology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000502:physiology; D007328:Insulin / Q000378:metabolism; D009765:Obesity / Q000150:complications; D016032:Randomized Controlled Trials as Topic; D013002:Somatomedins / Q000378:metabolism
chemical_list: D012739:Gonadal Steroid Hormones; D007328:Insulin; D013002:Somatomedins