title: Pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem, in healthy male Caucasian volunteers.
abstract: The CS-023 concentration in plasma after administration by infusion to healthy volunteers at a dose of 700 mg was decreased, with a half-life of 1.7 h, and the cumulative urinary excretion was 59.4% of the dose. The total clearance, renal clearance, and volume of distribution were 8.12 liters/h, 4.14 liters/h, and 17.2 liters, respectively.
authors.affiliation: Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan. sibaya@sankyo.co.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shibayama
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsushita
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirota
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ikeda
authors.forename: Shogo
authors.initials: S
authors.lastname: Kuwahara
mesh_terms: D019540:Area Under Curve; D015780:Carbapenems / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D015394:Molecular Structure; D044465:White People
chemical_list: D015780:Carbapenems; C492232:tomopenem