Modulation of catalytic RNA biological activity by small molecule effectors.
Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are capable of serving as a new molecular target for a variety of drugs and as a reliable screening system for their biological activity.
Vourekas
Anastassios
A
Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.
Kalavrizioti
Dimitra
D
Stathopoulos
Constantinos
C
Drainas
Denis
D
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D016337:RNA, Catalytic