title: Autocalibrating parallel imaging of in vivo trabecular bone microarchitecture at 3 Tesla.
abstract: In this work the generalized autocalibrating partially parallel acquisition (GRAPPA) technique was implemented with modified reconstruction and applied to in vivo high-resolution (HR) magnetic resonance imaging (MRI) of the trabecular bone microarchitecture at 3 Tesla (T) with a multiple-acquisition balanced steady-state free precession (b-SSFP) sequence. Trabecular bone is made up of a network of microstructures (80-140 microm), and its structural deterioration is associated with the skeletal metabolic disorder osteoporosis. HR-MRI is a promising noninvasive tool for assessing the trabecular microarchitecture in vivo, but it involves long acquisition times. Using partially parallel imaging (PPI) to accelerate the acquisition may help mitigate this shortcoming and allow more flexibility in protocol design. In this study the effects of GRAPPA-based reconstruction on image characteristics and the measurement of trabecular bone structural parameters were evaluated. Initial studies showed that image quality and depiction of microstructure were preserved in the GRAPPA-based reconstruction, indicating the feasibility of PPI in HR-MRI of trabecular bone. The results also demonstrated the potential of PPI for increasing the signal-to-noise ratio (SNR) efficiency of multiple-acquisition b-SSFP imaging protocols.
authors.affiliation: Department of Radiology, University of California-San Francisco, San Francisco, California 94158, USA. banerjee@mrsc.ucsf.edu
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
authors.forename: S
authors.initials: S
authors.lastname: Choudhury
authors.forename: E T
authors.initials: ET
authors.lastname: Han
authors.forename: A C S
authors.initials: AC
authors.lastname: Brau
authors.forename: C V
authors.initials: CV
authors.lastname: Morze
authors.forename: D B
authors.initials: DB
authors.lastname: Vigneron
authors.forename: S
authors.initials: S
authors.lastname: Majumdar
mesh_terms: D000465:Algorithms; D002111:Calcaneus / Q000166:cytology*; D002138:Calibration; D005240:Feasibility Studies; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity