Inflammatory peeling skin syndrome studied with electron microscopy.
Peeling skin syndrome is a rare autosomal recessive dermatosis characterized by lifelong continual skin shedding with underlying erythema. We present a 10-year-old boy with this disease. Easy peeling of the skin associated with keratotic areas was observed. Microscopic findings included psoriasiformis dermatitis. Cleavage was observed between corneocytes as well as between granular-corneum cells and within the granular cell layer. Electron microscopic findings included intra- and intercellular cleavage of corneocytes and intracellular separation of granular cells. The molecular mechanisms of peeling skin syndrome are discussed.
Tsai
Katia
K
Department of Dermatology, Medical School of University of São Paulo, São Paulo, Brazil. katiatsai@yahoo.com
Valente
Neusa Yuriko Sakae
NY
Nico
Marcello Menta Simonsen
MM
D002648:Child; D003873:Dermatitis, Exfoliative / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D013577:Syndrome