title: [A case of advanced gastric cancer--efficacy of combination therapy of doxifluridine and weekly paclitaxel].
abstract: A 65-year-old man underwent distal gastrectomy for advanced gastric cancer. Histological examination revealed that a lymph node metastasis extended to the para-aortic nodes. After operation, he was treated with TS-1 as first-line chemotherapy. After 10 months of the first-line chemotherapy, the lymph node swelling increased in size, and new lesions were detected. Then, the patient was treated by combination therapy of doxifluridine and weekly paclitaxel. Weekly paclitaxel administration (PTX 80 mg/m(2), 2 consecutive weeks, 1 week break) and oral administration of doxifluridine (600 mg/m(2), 14 consecutive days) were performed as the second-line chemotherapy. After 2 courses, abdominal CT scan showed a remarkable reduction of the para-aortic lymph nodes. The second-line chemotherapy was continued until the 7th course, then stopped without progression of the disease, and the patient maintained good quality of life. PTX/5'-DFUR combination therapy was thought to be an effective chemotherapy for advanced gastric cancer.
authors.affiliation: Third Dept. of Surgery, Toho University School of Medicine.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Jiro
authors.initials: J
authors.lastname: Nagao
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Saida
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Enomoto
authors.forename: Miwa
authors.initials: M
authors.lastname: Katagiri
authors.forename: Sayaka
authors.initials: S
authors.lastname: Nagao
authors.forename: Manabu
authors.initials: M
authors.lastname: Watanabe
authors.forename: Shinya
authors.initials: S
authors.lastname: Kusachi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Sumiyama
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001011:Aorta; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005467:Floxuridine / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D005467:Floxuridine; D017239:Paclitaxel; C025034:doxifluridine