The safety of mineral oil in the treatment of constipation--a lesson from prolonged overdose.
There have been concerns regarding the interference in the absorption of fat-soluble vitamins in long-term treatment with mineral oil; however, there is no clear evidence in the literature to support this claim. We present a case report illustrating the effect of prolonged (5 months) large doses of mineral oil on the fat-soluble vitamin absorption in a 17-year-old girl.
Gal-Ezer
Sharon
S
Department of Pediatrics, Bnai Zion Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Shaoul
Ron
R
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003248:Constipation / Q000097:blood* / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D004643:Emollients / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008286:Malabsorption Syndromes / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D008899:Mineral Oil / Q000008:administration & dosage / Q000009:adverse effects*; D011092:Polyethylene Glycols / Q000009:adverse effects; D014801:Vitamin A / Q000097:blood; D014807:Vitamin D / Q000097:blood; D014810:Vitamin E / Q000097:blood; D014812:Vitamin K / Q000097:blood; D014815:Vitamins / Q000097:blood* / Q000493:pharmacokinetics
D015415:Biomarkers; D004643:Emollients; D014815:Vitamins; D014801:Vitamin A; D014812:Vitamin K; D014807:Vitamin D; D014810:Vitamin E; D011092:Polyethylene Glycols; D008899:Mineral Oil