title: Dactinomycin-induced, severe lichenoid eruption in a child.
abstract: There is little information in the medical literature about skin rashes associated with dactinomycin in the absence of radiotherapy. We report a 12-month-old male child who developed a severe cutaneous reaction that consisted of a widespread pruritic papular eruption associated with fever and a poor general state after dactinomycin administration. Skin biopsy specimen findings confirmed the diagnosis of lichenoid eruption. The rash improved with topical steroid treatment and completely resolved within 1 month with persistence of a residual mild hyperpigmentation. Dactinomycin administration was discontinued for the remaining cycles of chemotherapy.
authors.affiliation: Department of Pediatric Oncology, Gustave Roussy Institute, Villejuif, France.
authors.forename: V
authors.initials: V
authors.lastname: Ridola
authors.forename: E
authors.initials: E
authors.lastname: Mahé
authors.forename: O
authors.initials: O
authors.lastname: Fawaz
authors.forename: L
authors.initials: L
authors.lastname: Galmiche
authors.forename: C
authors.initials: C
authors.lastname: Patte
authors.forename: J
authors.initials: J
authors.lastname: Grill
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D003609:Dactinomycin / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D017512:Lichenoid Eruptions / Q000139:chemically induced* / Q000473:pathology; D008297:Male
chemical_list: D000903:Antibiotics, Antineoplastic; D003609:Dactinomycin