Effect of menopause and renal function on vitamin D status in Iranian women.
The effects of menopause and renal function on serum parameters of the vitamin D-endocrine system were studied in a cross-sectional sample of 676 healthy women aged 20-74 years in Shiraz. Low serum 25-hydroxyvitamin D (25-OHD) was found in 52.9% of the women. Serum parathyroid hormone (PTH) increased significantly over the age span in premenopausal women (r= 0.13, P= 0.02). In premenopausal and postmenopausal women, serum levels of 25-OHD, phosphorus and calcium were stable across the age span. There was no significant correlation between creatinine clearance or serum PTH (r= -0.016, P= 0.66) and 25-OHD (r= 0.012, P= 0.74). The high prevalence of vitamin D deficiency warrants consideration of dietary supplementation.
Omrani
G R
GR
Endocrine and Metabolism Research Centre, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. hormone@sums.ac.ir
Masoompour
S M
SM
Sadegholvaad
A
A
Larijani
B
B
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D007492:Iran / Q000453:epidemiology; D007668:Kidney / Q000502:physiology*; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D017698:Postmenopause / Q000502:physiology; D017697:Premenopause / Q000502:physiology; D015995:Prevalence; D012494:Sampling Studies; D014504:Urban Health / Q000706:statistics & numerical data; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology / Q000209:etiology
D010281:Parathyroid Hormone; D014807:Vitamin D; D010758:Phosphorus; C104450:25-hydroxyvitamin D; D003404:Creatinine; D000469:Alkaline Phosphatase; D002118:Calcium