title: Delta-cyclodextrin as novel chiral probe for enantiomeric separation by electromigration methods.
abstract: Native delta-CD has been employed as chiral selector in CE and MEKC. To investigate the potential of the enantiodiscriminating properties of delta-CD, negatively charged 5-dimethylamino-1-naphthalene-sulfonyl (dansyl)-, 2,4-dinitrophenyl (DNP)- and FMOC-derivatives of several amino acids, 1,1'-binaphthyl-2,2'-diylhydrogenphosphate, flavanones and three positively charged drugs have been selected as testing samples. Enantioresolution factors up to 4.82 have been observed. The results were compared with those achieved by the conventional running buffer additives alpha-, beta- and gamma-CDs. For several examples a steady increase of enantioresolution with increasing degree of oligomerization has been detected.
authors.affiliation: Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Wistuba
authors.forename: Anja
authors.initials: A
authors.lastname: Bogdanski
authors.forename: Kim L
authors.initials: KL
authors.lastname: Larsen
authors.forename: Volker
authors.initials: V
authors.lastname: Schurig
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification; D002021:Buffers; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry*; D003619:Dansyl Compounds / Q000737:chemistry / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000379:methods*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification; D015335:Molecular Probes / Q000737:chemistry*; D009281:Naphthalenes / Q000302:isolation & purification; D010755:Organophosphates / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002021:Buffers; D003505:Cyclodextrins; D003619:Dansyl Compounds; D044950:Flavanones; D015335:Molecular Probes; D009281:Naphthalenes; D010755:Organophosphates; D004364:Pharmaceutical Preparations; C121706:delta-cyclodextrin; C107195:1,1'-binaphthyl-2,2'-diyl hydrogen phosphate