title: Solution structures of thiopeptide antibiotics.
abstract: A detailed NMR study of the thiopeptide amythiamicin D establishes its solution conformation and the presence of a single intramolecular hydrogen bond involving NH13 and O28, and also provides the first evidence for self-association of thiopeptides in solution.
authors.affiliation: AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire, UK LE11 5RH.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Lewis
authors.forename: Rachael A
authors.initials: RA
authors.lastname: Hughes
authors.forename: Lilian
authors.initials: L
authors.lastname: Alcaraz
authors.forename: Stewart P
authors.initials: SP
authors.lastname: Thompson
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Moody
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006860:Hydrogen Bonding; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry; D011487:Protein Conformation; D012996:Solutions; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D047028:Macrocyclic Compounds; D010456:Peptides, Cyclic; D012996:Solutions; D013844:Thiazoles; C088501:amythiamicin D