Enfuvirtide: patient acceptance and strategies for managing injection-site reactions.
Enfuvirtide is a virologically and immunologically active, injectable antiretroviral fusion inhibitor developed for the treatment of HIV infection. Patients have shown high adherence rates related to self-preparation (reconstitution) and self-administration of enfuvirtide. This review discusses the efficacy and acceptability of enfuvirtide and offers advice to help health care professionals and patients address concerns about self-injection. Practical interventions that can help minimize and manage the impact of injection-site reactions are described, including the use of a needle-free device for administering the drug.
Rice
Chris
C
Vista Medical Partners, Beverly Hills, California, USA.
Wilantewicz
Heather
H
D003875:Drug Eruptions / Q000209:etiology / Q000517:prevention & control*; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41 / Q000008:administration & dosage* / Q000009:adverse effects; D023581:HIV Fusion Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects; D010349:Patient Compliance; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000009:adverse effects; D012646:Self Administration
D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010446:Peptide Fragments; D000077560:Enfuvirtide