title: Amygdala activation in the processing of neutral faces in social anxiety disorder: is neutral really neutral?
abstract: Previous research has suggested that Social Anxiety Disorder (SAD) is associated with a tendency to interpret ambiguous social stimuli in a threatening manner. The present study used event-related functional magnetic resonance imaging to examine patterns of neural activation in response to the processing of neutral facial expressions in individuals diagnosed with SAD and healthy controls (CTLs). The SAD participants exhibited a different pattern of amygdala activation in response to neutral faces than did the CTL participants, suggesting a neural basis for the biased processing of ambiguous social information in SAD individuals.
authors.affiliation: Department of Psychology, Bldg. 420, Jordan Hall, Stanford University, Stanford, CA 94305, USA. rcooney@psych.stanford.edu
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Cooney
authors.forename: Lauren Y
authors.initials: LY
authors.lastname: Atlas
authors.forename: Jutta
authors.initials: J
authors.lastname: Joormann
authors.forename: Fanny
authors.initials: F
authors.lastname: Eugène
authors.forename: Ian H
authors.initials: IH
authors.lastname: Gotlib
mesh_terms: D000328:Adult; D000679:Amygdala / Q000503:physiopathology*; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D003118:Color Perception / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology*; D018187:Personal Construct Theory; D010698:Phobic Disorders / Q000503:physiopathology* / Q000523:psychology