Regulation of ENaCs by proteases: An increasingly complex story.
Proteolytic processing of epithelial Na+ channel (ENaC) subunits has an important role in the regulation of ENaC gating. This Commentary addresses the potential roles of specific proteases and protease inhibitors in the control of Na+ channel gating.
Kleyman
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Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. kleyman@pitt.edu
Myerburg
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Hughey
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D016564:Amyloid beta-Protein Precursor / Q000502:physiology*; D000818:Animals; D053503:Epithelial Sodium Channels; D005260:Female; D015640:Ion Channel Gating / Q000502:physiology; D051379:Mice; D009865:Oocytes / Q000502:physiology; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors; D058255:Protease Nexins; D011956:Receptors, Cell Surface / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology; D015222:Sodium Channels / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D014981:Xenopus; D000099271:Prostasin
D016564:Amyloid beta-Protein Precursor; D053503:Epithelial Sodium Channels; D010447:Peptide Hydrolases; D011480:Protease Inhibitors; D058255:Protease Nexins; D011956:Receptors, Cell Surface; D012697:Serine Endopeptidases; D015222:Sodium Channels; D000099271:Prostasin