title: Brain volume changes in the first year of illness and 5-year outcome of schizophrenia.
abstract: Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia.
authors.affiliation: Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 GX Utrecht, The Netherlands. wcahn@umcutrecht.nl
authors.forename: W
authors.initials: W
authors.lastname: Cahn
authors.forename: N E M
authors.initials: NE
authors.lastname: van Haren
authors.forename: H E
authors.initials: HE
authors.lastname: Hulshoff Pol
authors.forename: H G
authors.initials: HG
authors.lastname: Schnack
authors.forename: E
authors.initials: E
authors.lastname: Caspers
authors.forename: D A J
authors.initials: DA
authors.lastname: Laponder
authors.forename: R S
authors.initials: RS
authors.lastname: Kahn
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D012559:Schizophrenia / Q000209:etiology / Q000473:pathology*; D013997:Time Factors