Bone tissue engineering using foetal cell therapy.
Different cell sources for bone tissue engineering are reviewed. In particular, adult cell source strategies have been based on the implantation of unfractionated fresh bone marrow; purified, culture expanded mesenchymal stem cells, differentiated osteoblasts, or cells that have been modified genetically to express rhBMP. Several limiting factors are mentioned for these strategies such as low number of available cells or possible immunological reaction of the host. Foetal bone cells are presented as an alternative solution and review of actual treatments using these cells is presented. Finally, foetal cells used specifically for bone tissue engineering are characterised and potentially interesting therapeutic options are proposed.
Pioletti
Dominique P
DP
Laboratoire de Biomécanique en Orthopédie EPFL-HOSR, Institut de Biomécanique Translationnelle, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. dominique.pioletti@epfl.ch
Montjovent
Marc-Olivier
MO
Zambelli
Pierre-Yves
PY
Applegate
Lee
L
D001861:Bone Regeneration; D001842:Bone and Bones / Q000166:cytology*; D064987:Cell- and Tissue-Based Therapy; D033042:Fetal Research; D006801:Humans; D013234:Stem Cells; D013557:Switzerland; D023822:Tissue Engineering