Use of recombinant factor VIIa, Novo Seven, in the management of acute haemorrhage.
OBJECTIVE
The purpose of this paper is to propose the use of factor VIIa in treating severely bleeding patients.


RESULTS
Recombinant factor VIIa was developed in 1988 to treat patients with haemophilia A or B and antibodies against factors VIII and IX, or patients with a spontaneous inhibitor against factors VIII and IX. Since then factor VIIa has been shown to be very effective in treating many other bleeding disorders, such as diverse thrombocytopathias, antibodies against other coagulation proteins like factor V, and bleeding as a result of oral anticoagulation.


CONCLUSIONS
Recombinant factor VIIa may be the universal haemostatic agent, but further studies are needed to prove this.
Rott
Hannelore
H
Laboratory and Ambulance for Coagulation Disorders, Duisburg, Germany.
Trobisch
Heiner
H
Kretzschmar
Evelyne
E