De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: successful treatment with autologous peripheral blood stem cell transplantation.
Basophils play an important role in allergic inflammation and are pathologically related to hematological disturbances, such as iron deficiency anemia and myeloproliferative disorders; however, they are only rarely encountered in lymphoid malignancies. Here, we report the case of a 33-year-old man with a bulky mass of the small intestine, multiple paraaortic lymphoadenopathy, pleural effusion, and ascites, who was diagnosed as a case of de novo CD5+ diffuse large B cell lymphoma (DLBCL). This patient showed a marked elevation of the basophil count in the peripheral blood, which appeared to run in parallel with the tumor burden. High dose chemotherapy followed by autologous peripheral blood cell transplantation yielded complete remission, and the patient has remained disease free for 5 years. To the best of our knowledge, this is the first report of a case of de novo CD5+ DLBCL showing marked elevation of the PB basophil count.
Tokuhira
Michihide
M
Division of Hematology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan. tokuhira@saitama-med.ac.jp
Watanabe
Reiko
R
Iizuka
Atsushi
A
Sekiguchi
Yasunobu
Y
Nemoto
Tomoe
T
Hanzawa
Kyoko
K
Takamatsu
Ichiro
I
Maruyama
Taro
T
Tamaru
Jun-ichi
J
Itoyama
Shinji
S
Suzuki
Hiroshi
H
Takeuchi
Tsutomu
T
Mori
Shigehisa
S
D000328:Adult; D001201:Ascites / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D044466:Asian People; D001491:Basophils / Q000473:pathology; D018956:CD5 Antigens; D006801:Humans; D007414:Intestinal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D007564:Japan; D016393:Lymphoma, B-Cell / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D016066:Pleural Effusion, Malignant / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011859:Radiography; D012074:Remission Induction; D014182:Transplantation, Autologous; D047368:Tumor Burden
D018956:CD5 Antigens