In vitro activities of the novel oxazolidinones DA-7867 and DA-7157 against rapidly and slowly growing mycobacteria.
DA-7867 and DA-7157 are oxazolidinones active against pathogenic aerobic actinomycetes including Nocardia spp. and Mycobacterium tuberculosis. However, the activity of these drugs against nontuberculous mycobacterium (NTM) species is not known. In this work, we compared the susceptibilities of 122 clinical isolates and 29 reference species of both rapidly growing and slowly growing mycobacteria to linezolid, DA-7867, and DA-7157 by the broth microdilution method. The MICs for 50 and 90% of the strains tested (MIC50s and MIC90s, respectively) of DA-7867 and DA-7157 were lower than those of linezolid. In all of the cases, a MIC90 of <8 microg/ml was observed for all of the species tested in both groups of NTM. For M. kansasii and M. marinum isolates, the MIC90s of both DA-7867 and DA-7157 were less than 0.5 microg/ml. These results demonstrate the potential of these compounds to treat NTM infections.
Vera-Cabrera
Lucio
L
Servicio de Dermatología, Hospital Universitario José E. González, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, NL, México. luvera_99@yahoo.com
Brown-Elliott
Barbara A
BA
Wallace
Richard J
RJ
Ocampo-Candiani
Jorge
J
Welsh
Oliverio
O
Choi
Sung Hak
SH
Molina-Torres
Carmen A
CA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007201:Indicator Dilution Techniques; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D015269:Mycobacterium avium Complex / Q000187:drug effects; D016926:Mycobacterium chelonae / Q000187:drug effects; D019907:Mycobacterium fortuitum / Q000187:drug effects; D019909:Mycobacterium kansasii / Q000187:drug effects; D019910:Mycobacterium marinum / Q000187:drug effects; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones / Q000494:pharmacology*; D013777:Tetrazoles / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; C515039:DA 7157; C480487:DA-7867; D010080:Oxazoles; D023303:Oxazolidinones; D013777:Tetrazoles