title: The expression of PRDI-BF1 beta isoform in multiple myeloma plasma cells.
abstract: The PRDM1 gene, a master regulator of plasma cells (PC), can generate two transcription factor isoforms: PRDI-BF1alpha and PRDI-BF1beta. The present study shows that purified human normal PC have a significantly lower levels of PRDI-BF1beta expression than that in tumoral PC isolated from multiple myeloma (MM) (0.06+/-0.01 and 0.25+/-0.05, respectively; p<0.001). The role of this finding in MM is discussed.
authors.forename: Esther
authors.initials: E
authors.lastname: Ocaña
authors.forename: Inés
authors.initials: I
authors.lastname: González-García
authors.forename: Norma C
authors.initials: NC
authors.lastname: Gutiérrez
authors.forename: Francisco
authors.initials: F
authors.lastname: Mora-López
authors.forename: José A
authors.initials: JA
authors.lastname: Brieva
authors.forename: Antonio
authors.initials: A
authors.lastname: Campos-Caro
mesh_terms: D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000378:metabolism*; D010950:Plasma Cells / Q000378:metabolism*; D000074462:Positive Regulatory Domain I-Binding Factor 1; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D012097:Repressor Proteins / Q000096:biosynthesis* / Q000235:genetics; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D020033:Protein Isoforms; D012097:Repressor Proteins; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1