Gene therapy of liver cancer.
The application of gene transfer technologies to the treatment of cancer has led to the development of new experimental approaches like gene directed enzyme/pro-drug therapy (GDEPT), inhibition of oncogenes and restoration of tumor-suppressor genes. In addition, gene therapy has a big impact on other fields like cancer immunotherapy, anti-angiogenic therapy and virotherapy. These strategies are being evaluated for the treatment of primary and metastatic liver cancer and some of them have reached clinical phases. We present a review on the basis and the actual status of gene therapy approaches applied to liver cancer.
Hernandez-Alcoceba
Ruben
R
Division of Gene Therapy and Hepatology, Edificio CIMA, Av. Pio XII, 55, Pamplona 31008, Spain.
Sangro
Bruno
B
Prieto
Jesus
J
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D017209:Apoptosis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D015870:Gene Expression; D018390:Gene Targeting; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008113:Liver Neoplasms / Q000628:therapy*; D009857:Oncogenes; D050130:Oncolytic Virotherapy / Q000379:methods; D011355:Prodrugs / Q000627:therapeutic use
D020533:Angiogenesis Inhibitors; D011355:Prodrugs