[Experimental study on the therapeutic effect of liposome-entrapped antibiotics in the treatment of destructive pneumonia].
The data on preparation of liposome-entrapped gentamicin sulfate and cefoperazone and their investigation on albino mice with staphylococcal destructive pneumonia are presented. Comparative study of the efficacy of gentamicin sulfate and cefoperazone in free and liposome-entrapped forms showed that immobilization of the antibiotics in phospholipid vesicles provided a 2-fold increase of their efficacy.
Rotov
K A
KA
Tikhonov
S N
SN
Alekseev
V V
VV
Khrapova
N P
NP
Snatenkov
E A
EA
Zamarin
A A
AA
Simakova
N A
NA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002438:Cefoperazone / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D008081:Liposomes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008081:Liposomes; D002438:Cefoperazone