title: [Characterization of proteinuria in patients with ulcerative colitis and therapy with aminosalicylates].
abstract: OBJECTIVE
  Patients with ulcerative colitis have a higher rate of tubular nephropathies. Data concerning the cause of these lesions is rare and inconsistent, the occurrence may be part of the disease itself or a side effect of 5-aminosalicylates (5-ASA). This study investigated proteinuria and eosinophiluria in patients with moderate ulcerative colitis under treatment with 5-ASA.
  
  
  METHODS
  Urine specimens (microelectrophoresis and eosinophiluria) of 34 patients with acute onset of moderate ulcerative colitis who were treated only with 5-ASA as active drug were analyzed.
  
  
  RESULTS
  Data of 27 patients could be evaluated. Twelve patients had tubular proteinuria previous to treatment. By the end of the study, urine specimens normalized in six, in further six the proteinuria remained unaltered, two patients developed proteinuria under treatment. In 14 patients, proteinuria was not detectable at any time. Eosinophiluria was found in none of the specimens.
  
  
  CONCLUSIONS
  Under treatment with 5-ASA no toxic or allergic nephropathy developed. One initially pathologic urine specimen normalized under treatment coming along with remission of the intestinal symptoms and histological findings. This indicates an association between the activity of the ulcerative colitis and might be caused by renal excretion of pro-inflammatory cytokines.
authors.affiliation: Medizinische Klinik I, Kliniken der Stadt Köln gGmbH, Köln-Merheim.
authors.forename: Lutz
authors.initials: L
authors.lastname: Buschhausen
authors.forename: Werner
authors.initials: W
authors.lastname: Kruis
authors.forename: Serhat
authors.initials: S
authors.lastname: Aymaz
authors.forename: Manfred
authors.initials: M
authors.lastname: Weber
authors.forename: Bernd
authors.initials: B
authors.lastname: Krakamp
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy / Q000652:urine; D005260:Female; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology* / Q000652:urine; D007958:Leukocyte Count; D008297:Male; D019804:Mesalamine / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology* / Q000652:urine; D012307:Risk Factors
chemical_list: D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine; C032587:olsalazine