Novel, efficient total synthesis of natural 20(S)-camptothecin.
Enantiopure 20(S)-camptothecin has been prepared from a known hydroxypyridone through a novel approach that involves a Claisen rearrangement, an asymmetric nucleophilic ethylation, a Heck coupling and a Friedländer condensation as the key transformations.
Tang
Chao-Jun
CJ
Chimie Recherche (LEDSS), Université Joseph Fourier, 38041 Grenoble, France.
Babjak
Matej
M
Anderson
Regan J
RJ
Greene
Andrew E
AE
Kanazawa
Alice
A
D002166:Camptothecin / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D002166:Camptothecin