title: Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC).
abstract: BACKGROUND
  The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected.
  
  
  METHODS
  We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped.
  
  
  RESULTS
  Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12.
  
  
  CONCLUSIONS
  These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.
authors.affiliation: Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
authors.forename: Agnes B
authors.initials: AB
authors.lastname: Baffoe-Bonnie
authors.forename: Rick A
authors.initials: RA
authors.lastname: Kittles
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Gillanders
authors.forename: Liang
authors.initials: L
authors.lastname: Ou
authors.forename: Asha
authors.initials: A
authors.lastname: George
authors.forename: Christiane
authors.initials: C
authors.lastname: Robbins
authors.forename: Chiledum
authors.initials: C
authors.lastname: Ahaghotu
authors.forename: James
authors.initials: J
authors.lastname: Bennett
authors.forename: William
authors.initials: W
authors.lastname: Boykin
authors.forename: Gerald
authors.initials: G
authors.lastname: Hoke
authors.forename: Terry
authors.initials: T
authors.lastname: Mason
authors.forename: Curtis
authors.initials: C
authors.lastname: Pettaway
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Vijayakumar
authors.forename: Sally
authors.initials: S
authors.lastname: Weinrich
authors.forename: Mary P
authors.initials: MP
authors.lastname: Jones
authors.forename: Derek
authors.initials: D
authors.lastname: Gildea
authors.forename: Erica
authors.initials: E
authors.lastname: Riedesel
authors.forename: Julie
authors.initials: J
authors.lastname: Albertus
authors.forename: Tracy
authors.initials: T
authors.lastname: Moses
authors.forename: Erica
authors.initials: E
authors.lastname: Lockwood
authors.forename: Meghan
authors.initials: M
authors.lastname: Klaric
authors.forename: Mezbah
authors.initials: M
authors.lastname: Faruque
authors.forename: Charmaine
authors.initials: C
authors.lastname: Royal
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Trent
authors.forename: Kate
authors.initials: K
authors.lastname: Berg
authors.forename: Francis S
authors.initials: FS
authors.lastname: Collins
authors.forename: Paulette M
authors.initials: PM
authors.lastname: Furbert-Harris
authors.forename: Joan E
authors.initials: JE
authors.lastname: Bailey-Wilson
authors.forename: Georgia M
authors.initials: GM
authors.lastname: Dunston
authors.forename: Isaac
authors.initials: I
authors.lastname: Powell
authors.forename: John D
authors.initials: JD
authors.lastname: Carpten
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000368:Aged; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics*; D014481:United States
chemical_list: D005819:Genetic Markers