title: Radical-scavenging activities of new megastigmane glucosides from Macaranga tanarius (L.) MULL.-ARG.
abstract: Four new megastigmane glucosides, named macarangiosides A-D (2-5), together with mallophenol B, lauroside E, methyl brevifolin carboxylate, and hyperin and isoquercitrin as a mixture were isolated from the leaves of Macaranga tanarius (L.) MULL.-ARG. (Euphorbiaceae). Their structures were elucidated by spectroscopic and chemical analyses. Macarangioside A-C (2-4) and mallophenol B were galloylated on glucose moiety and possessed the potent 2,2-diphenyl-picrylhydrazyl (DPPH) radical-scavenging activity.
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
authors.forename: Ichiko
authors.initials: I
authors.lastname: Takamori
authors.forename: Takakazu
authors.initials: T
authors.lastname: Shinzato
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Aramoto
authors.forename: Kazunari
authors.initials: K
authors.lastname: Kondo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takeda
mesh_terms: D000475:Alkenes / Q000737:chemistry* / Q000302:isolation & purification; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000302:isolation & purification; D003512:Cyclohexanones / Q000737:chemistry*; D019665:Euphorbiaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D045792:Norisoprenoids / Q000737:chemistry*; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D001952:Bridged-Ring Compounds; D003512:Cyclohexanones; D016166:Free Radical Scavengers; D005960:Glucosides; D045792:Norisoprenoids; C516190:macarangioside A; C516189:macarangioside B; C516191:macarangioside C; C516192:macarangioside D; C413264:megastigmane