Natural inhibitors targeting osteoclast-mediated bone resorption.
Human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively.
Zeng
Guang-Zhi
GZ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
Tan
Ning-Hua
NH
Hao
Xiao-Jiang
XJ
Mu
Quan-Zhang
QZ
Li
Rong-Tao
RT
D001862:Bone Resorption / Q000517:prevention & control*; D056657:Cathepsin K; D002403:Cathepsins / Q000037:antagonists & inhibitors; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000037:antagonists & inhibitors*; D061965:Matrix Metalloproteinase Inhibitors; D010010:Osteoclasts / Q000187:drug effects / Q000502:physiology*; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology
D004791:Enzyme Inhibitors; D039302:Integrin alphaVbeta3; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D002403:Cathepsins; C534130:CTSK protein, human; D056657:Cathepsin K