title: Could adding magnesium as adjuvant to ropivacaine in caudal anaesthesia improve postoperative pain control?
abstract: Recently, most studies reported magnesium as a N-methyl-D-aspartate receptor antagonist and its analgesic and perioperative anaesthetic effects have been discussed with central desensitization pathway. We investigated the effects of caudal ropivacaine plus magnesium and compared with ropivacaine alone on postoperative analgesia requirements. After hospital ethic committee's consent, 60 patients (ASA I-II, 2-10 years old) who had lower abdominal or penoscrotal surgery were enrolled in the study. After general anaesthesia induction, caudal blockage was applied. Patients were randomly assigned in two groups. Ropivacaine 0.25% was administered to Group R (n=37), ropivacaine 0.25% plus 50 mg magnesium to Group RM (n=23) in 0.5 ml kg-1 volume. Postoperative analgesia level was recorded at 15 min and 1, 2, 3, 4, 6 h by using Paediatric Objective Pain Scale (POPS) and The Children's Hospital of Eastern Ontoria Pain Scale (CHEOPS). Postoperative motor blocks were evaluated with Modified Bromage Motor Block Scale. According to demographic characteristics, there were no significant differences between the two groups (P>0.05). POPS, CHEOPS, Bromage Motor Scales, analgesia duration and adverse effects were similar in Group R and Group RM. It has been shown that addition of magnesium as an adjuvant agent to local anaesthetics for caudal analgesia has no effect on postoperative pain and analgesic need.
authors.affiliation: Department of Anesthesiology and Reanimation, Mersin University Faculty of Medicine, 33079, Mersin, Turkey. birbicer@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Birbicer
authors.forename: N
authors.initials: N
authors.lastname: Doruk
authors.forename: I
authors.initials: I
authors.lastname: Cinel
authors.forename: S
authors.initials: S
authors.lastname: Atici
authors.forename: D
authors.initials: D
authors.lastname: Avlan
authors.forename: E
authors.initials: E
authors.lastname: Bilgin
authors.forename: U
authors.initials: U
authors.lastname: Oral
mesh_terms: D000577:Amides / Q000627:therapeutic use*; D000763:Anesthesia, Caudal; D000779:Anesthetics, Local; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D008274:Magnesium