Delta-cyclodextrin as novel chiral probe for enantiomeric separation by electromigration methods.
Native delta-CD has been employed as chiral selector in CE and MEKC. To investigate the potential of the enantiodiscriminating properties of delta-CD, negatively charged 5-dimethylamino-1-naphthalene-sulfonyl (dansyl)-, 2,4-dinitrophenyl (DNP)- and FMOC-derivatives of several amino acids, 1,1'-binaphthyl-2,2'-diylhydrogenphosphate, flavanones and three positively charged drugs have been selected as testing samples. Enantioresolution factors up to 4.82 have been observed. The results were compared with those achieved by the conventional running buffer additives alpha-, beta- and gamma-CDs. For several examples a steady increase of enantioresolution with increasing degree of oligomerization has been detected.
Wistuba
Dorothee
D
Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany.
Bogdanski
Anja
A
Larsen
Kim L
KL
Schurig
Volker
V
D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification; D002021:Buffers; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry*; D003619:Dansyl Compounds / Q000737:chemistry / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000379:methods*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification; D015335:Molecular Probes / Q000737:chemistry*; D009281:Naphthalenes / Q000302:isolation & purification; D010755:Organophosphates / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000302:isolation & purification; D013237:Stereoisomerism
D000596:Amino Acids; D002021:Buffers; D003505:Cyclodextrins; D003619:Dansyl Compounds; D044950:Flavanones; D015335:Molecular Probes; D009281:Naphthalenes; D010755:Organophosphates; D004364:Pharmaceutical Preparations; C121706:delta-cyclodextrin; C107195:1,1'-binaphthyl-2,2'-diyl hydrogen phosphate