title: [Desensitization to cotrimoxazole, rifampicin and penicillin G in nine patients with prior hypersensitivity].
abstract: OBJECTIVE
  To present a protocol for the administration and development technique of the desensitization regimens for cotrimoxazole, rifampicin and penicillin G hypersensibility.
  
  
  METHODS
  A review of the available desensitization protocols for these antibiotics and a retrospective study of desensitization processes undertaken in the center from 1998. A development technique of the antibiotic dosages was designed.
  
  
  RESULTS
  Desensitization regimens for cotrimoxazole, rifampicin and penicillin G undertaken in the center in 9 patients came from a protocol by Glucksteins et al., Holland et al. and Wendal et al., respectively. After the literature review and the satisfactory results that allowed subsequent antibiotic administration in the 9 cases, these regimens were established as protocols of the center.
  
  
  CONCLUSIONS
  Dosage development and patient administration have a practical application and can help to decrease the potential mistakes related to the complexity of the process.
authors.affiliation: Servicio de Farmacia, Hospital Clínic, Barcelona. meritxell.pujal@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Pujal Herranz
authors.forename: M
authors.initials: M
authors.lastname: Roca Massa
authors.forename: P
authors.initials: P
authors.lastname: Domínguez Tordera
authors.forename: C
authors.initials: C
authors.lastname: Codina Jané
authors.forename: J
authors.initials: J
authors.lastname: Ribas Sala
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000276:immunology; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology / Q000628:therapy*; D006801:Humans; D010400:Penicillin G / Q000009:adverse effects* / Q000276:immunology; D012189:Retrospective Studies; D012293:Rifampin / Q000009:adverse effects / Q000276:immunology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000276:immunology
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D010400:Penicillin G; D012293:Rifampin