title: The role of cell adhesion molecules in ischemic epididymal injury.
abstract: OBJECTIVE
  The aim of this study was to investigate the role of adhesion molecules in epididymal injury induced by I-R in the rats.
  
  
  METHODS
  A total of 20 male Sprague-Dawley rats were separated into two groups. A sham operation was performed in group 1 (control). In group 2 (I-R), following 6 h of unilateral spermatic cord torsion, 1-h detorsion of the testis was performed. Then, epididymides were removed to measure the tissue levels of malondialdehyde (MDA) and to make histological examination.
  
  
  RESULTS
  MDA values increased in the group 2. In the group 2 rats demonstrated significant disorganization of the epithelium and loss of microvilli in the epididymal tissue. No abnormal microscopic findings of the epididymis of the rats in the control group. The tenascin expression in the interstitial area of the epididymis was intense in the group 2. ICAM-1 expression by intense brown staining was seen along the basement membrane in epididymal tissue from I to R group rats. The microvillus sites of the epithelia in I-R group were stained mildly by lectin.
  
  
  CONCLUSIONS
  The increased expression of adhesion molecules found in epididymal injury induced during postischemic reperfusion might implicate importance of inflammatory infiltration.
authors.affiliation: Department of Pediatric Surgery, Dicle University, Medical School, Diyarbakir, Turkey. ozturkhayrettin@hotmail.com
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Oztürk
authors.forename: Hulya
authors.initials: H
authors.lastname: Ozturk
authors.forename: Ali Ihsan
authors.initials: AI
authors.lastname: Dokucu
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004822:Epididymis / Q000098:blood supply*; D007511:Ischemia / Q000209:etiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015815:Cell Adhesion Molecules