title: A case of bone involvement in hairy cell leukemia successfully treated with radiation therapy.
abstract: We report the case of a 63-year-old man with a clearly established diagnosis of hairy cell leukemia, treated with multiple lines of chemotherapy, who complained of localized pain in the left humerus. Radiological findings showed a dystrophic-blastic area within the humeral head. Fine-needle biopsy confirmed the hypothesis of bone involvement of hairy cell leukemia. The patient underwent radiotherapy at a dose of 25 Gy, obtaining a complete clinical response with resolution of pain and a partial recovery of the normal radiological structure of the humerus after 2 months. In addition to the case report, we present a short review of the literature focusing on the role of radiotherapy in this subset of patients.
authors.affiliation: Dipartimento di Discipline Medico-Chirurgiche, SCDU Radioterapia, Università di Torino, Turin, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Franco
authors.forename: Andrea Riccardo
authors.initials: AR
authors.lastname: Filippi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fornari
authors.forename: Carlo
authors.initials: C
authors.lastname: Marinone
authors.forename: Umberto
authors.initials: U
authors.lastname: Ricardi
mesh_terms: D001706:Biopsy; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D006801:Humans; D006811:Humerus / Q000473:pathology / Q000528:radiation effects; D007943:Leukemia, Hairy Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D016896:Treatment Outcome