Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population.
BACKGROUND
The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (-1377G>A and -670A>G) and FASL (-844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case-control study in a Korean population.


METHODS
The FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender.


RESULTS
The FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer.


CONCLUSIONS
These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.
Park
Sun Ha
SH
Cancer Research Institute, School of Medicine, Kyungpook National University, Dong In 2Ga 101, Daegu 700-422, Republic of Korea.
Choi
Jin Eun
JE
Kim
Eun Jin
EJ
Jang
Jin Sung
JS
Lee
Won Kee
WK
Cha
Sung Ick
SI
Kim
Chang Ho
CH
Kam
Sin
S
Kim
Dong Sun
DS
Park
Rang-Woon
RW
Kim
Young-Chul
YC
Han
Sung Beom
SB
Jung
Tae Hoon
TH
Park
Jae Yong
JY
D044466:Asian People; D016022:Case-Control Studies; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D019014:fas Receptor / Q000235:genetics*
D053222:Fas Ligand Protein; D019014:fas Receptor