High-spatial-resolution multistation MR angiography with parallel imaging and blood pool contrast agent: initial experience.
The purpose of this study was to prospectively evaluate the diagnostic accuracy of reader detection of 75% or greater stenosis at high-spatial-resolution multistation magnetic resonance (MR) angiography performed with matrix coils and a blood pool contrast agent. Ten healthy volunteers and 10 patients were examined. All participants provided informed consent to participate in this institutional review board-approved study. For contrast agent-enhanced multistation MR angiography, an albumin-binding gadolinium chelate, gadofosveset trisodium, was used. Imaging was performed during the first-pass and steady-state phases of the contrast agent. Vessel conspicuity on the first-pass MR angiograms obtained in both volunteers and patients was rated as excellent for 93% of vessels. At steady-state imaging, vessel conspicuity was rated as excellent or good for 89% of vessels. Gadofosveset trisodium-enhanced MR angiography yielded sensitivities of 100% and 97% and specificities of 96% and 97% for detection of significant disease in the carotid and lower extremity arteries, respectively.
Nikolaou
Konstantin
K
Department of Clinical Radiology, Ludwig-Maximilians University of Munich, Grosshadern Campus, Marchioninistr 15, 81377 Munich, Germany. Konstantin.Nikolaou@med.uni-muenchen.de
Kramer
Harald
H
Grosse
Christina
C
Clevert
Dirk
D
Dietrich
Olaf
O
Hartmann
Mike
M
Chamberlin
Paul
P
Assmann
Stefan
S
Reiser
Maximilian F
MF
Schoenberg
Stefan O
SO
D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D003287:Contrast Media; D005682:Gadolinium; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D003287:Contrast Media; D009942:Organometallic Compounds; D005682:Gadolinium; C109932:gadofosveset trisodium