Studies on the constituents of the leaves of Baccharis dracunculifolia (Asteraceae) and their cytotoxic activity.
A new sesquiterpene, named baccharisketone (1), and a new monoterpene, p-methoxythymol acetate (2), were isolated from the leaves of Baccharis dracunculifolia along with seventeen known compounds (3-19). The structures of the new compounds were determined by spectroscopic means. The growth inhibitory activity of the isolated compounds against leukemia cells (L 1210) was tested and three terpene phenols (4, 6, 17) and five sesquiterpene alcohols (8, 10, 11, 13, 16) were found to exhibit strong cytotoxic activity.
Fukuda
Mamoru
M
College of Pharmacy, Nihon University, Funabashi, Chiba, Japan. mamoru.fukuda@mb.kyorin-pharm.co.jp
Ohkoshi
Emika
E
Makino
Mitsuko
M
Fujimoto
Yasuo
Y
D031175:Baccharis / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism
D039821:Monoterpenes; D012717:Sesquiterpenes; C516243:baccharisketone; C516244:methoxythymol acetate