Biosynthesis of quinolactacin A, a TNF production inhibitor.
Quinolactacins, which inhibit tumor necrosis factor production, contain a quinolone skeleton conjugated with a y-lactam. The biosynthesis of quinolactacin was investigated by feeding experiments using 13C single-labeled precursors (sodium [1-13C]acetate, DL-[1-13C]-isoleucine, L-[methyl-13C]methionine, and sodium [1-13C]-anthranilate) and D-[U-13C]glucose.
Sasaki
Tatsuya
T
Department of Biosciences, Teikyo University, 1-1 Toyosatodai, Utsunomiya, Tochigi 320-8551, Japan.
Takahashi
Senji
S
Uchida
Kenichi
K
Funayama
Shinji
S
Kainosho
Masatsune
M
Nakagawa
Akira
A
D015394:Molecular Structure; D010407:Penicillium / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
D015363:Quinolones; D014409:Tumor Necrosis Factor-alpha; C420723:quinolactacin A