Synthesis and anticancer activity studies of alpha-aminoalkylated conjugated nitroalkenes.
Novel alpha-aminoalkylated conjugated nitroalkenes which inhibit human cervical cancer (HeLa) cell proliferation by binding to tubulin were synthesized by imidazole/LiCl-mediated reaction of conjugated nitroalkenes with N-tosylimines.
Rastogi
Namrata
N
Department of Chemistry, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
Mohan
Renu
R
Panda
Dulal
D
Mobin
Shaikh M
SM
Namboothiri
Irishi N N
IN
D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009574:Nitro Compounds / Q000737:chemistry*
D000475:Alkenes; D000970:Antineoplastic Agents; D009574:Nitro Compounds