title: [Expression of Ezrin in gastric carcinoma and its significance].
abstract: OBJECTIVE
  To investigate the expression of Ezrin in gastric cancer, its role in tumor metastasis.
  
  
  METHODS
  Ezrin expression in tumor tissues from 90 gastric cancer cases and in normal gastric mucosa from 12 cases with benign disease was examined by immunohistochemical staining. Ezrin expression in gastric cancer cell lines was also detected by Western blot, and in vitro invasion assay was used to examine the invasive ability of the cell lines.
  
  
  RESULTS
  The expression rate of Ezrin was significantly higher in gastric cancer tissues than that in normal tissues (P< 0.05), and significantly correlated with lymph node metastasis (P< 0.05). Western blot showed that MKN-45 cell line had the highest expression of Ezrin among 5 gastric cancer cells. MKN-45 possessed highest invasion ability.
  
  
  CONCLUSIONS
  Ezrin expression is up-regulated, and may be associated with lymph node metastasis in gastric cancer.
authors.affiliation: Department of Surgery, Ruijin Hospital, School of Medical, Shanghai Jiaotong University, Shanghai Institute of Digestive Surgery, Shanghai 200025, China.
authors.forename: Rong-liang
authors.initials: RL
authors.lastname: Shi
authors.forename: Jian-fang
authors.initials: JF
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Qu
authors.forename: Xue-hua
authors.initials: XH
authors.lastname: Chen
authors.forename: Qin-long
authors.initials: QL
authors.lastname: Gu
authors.forename: Zheng-gang
authors.initials: ZG
authors.lastname: Zhu
authors.forename: Bing-ya
authors.initials: BY
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D040081:Protein Array Analysis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D000099149:Ezrin
chemical_list: D003598:Cytoskeletal Proteins; D000099149:Ezrin