title: Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3.
abstract: OBJECTIVE
  Genome-wide linkage analyses of schizophrenia have identified several regions that may harbor schizophrenia susceptibility genes, but given the complex etiology of the disorder, it is unlikely that all susceptibility regions have been detected. To address this issue, the authors ascertained 606 Han Chinese families comprising 1,234 affected members.
  
  
  METHODS
  Probands with schizophrenia were recruited from six data collection field research centers in Taiwan. Each proband underwent a diagnostic screen with supplemental medical records and a semistructured interview. Following this screen, the authors administered the Mandarin Chinese version of the Diagnostic Interview for Genetic Studies. Best-estimate final diagnoses were made by two board-certified psychiatrists. The genotyping was conducted by the Center for Inherited Disease Research, with 386 markers spaced at an average of 9-centimorgan (cM) intervals. Empirical simulations were generated to determine genome-wide significance.
  
  
  RESULTS
  The authors found five regions with nonparametric linkage z scores 2.0 or greater. These were the following: 2.08 was reached for D1S551 (113.7) cM at 1p31.1 and 2.31 for D2S410 (125.2 cM) at 2q14.1; 2.00 was reached for D4S2361 (93.5 cM) at 4q21.23, and 2.07 for D15S1012 (36 cM) at 15q14, the largest nonparametric linkage z score was 2.88 for D10S2327 (100.92 cM) at 10q22.3.
  
  
  CONCLUSIONS
  Our 10q22.3 finding at 100.9 cM is consistent with a previously reported nonparametric linkage score of 4.27 at 107.2 cM on chromosome 10, although it did not attain genome-wide significance in this study.
authors.affiliation: Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA. faraones@upstate.edu
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Faraone
authors.forename: Hai-Gwo
authors.initials: HG
authors.lastname: Hwu
authors.forename: Chih-Min
authors.initials: CM
authors.lastname: Liu
authors.forename: Wei J
authors.initials: WJ
authors.lastname: Chen
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Tsuang
authors.forename: Shih-Kai
authors.initials: SK
authors.lastname: Liu
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Shieh
authors.forename: Tzung-Jeng
authors.initials: TJ
authors.lastname: Hwang
authors.forename: Wen-Chen
authors.initials: WC
authors.lastname: Ou-Yang
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Chen
authors.forename: Chwen-Cheng
authors.initials: CC
authors.lastname: Chen
authors.forename: Jin-Jia
authors.initials: JJ
authors.lastname: Lin
authors.forename: Frank Huang-Chih
authors.initials: FH
authors.lastname: Chou
authors.forename: Ching-Mo
authors.initials: CM
authors.lastname: Chueh
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Liu
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Hall
authors.forename: Jessica
authors.initials: J
authors.lastname: Su
authors.forename: Paul
authors.initials: P
authors.lastname: Van Eerdewegh
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics* / Q000276:immunology*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D013624:Taiwan / Q000208:ethnology
chemical_list: D005819:Genetic Markers