title: Proliferative effect of the aqueous extract of Hyptis pectinata on liver regeneration after partial hepatectomy in rats.
abstract: OBJECTIVE
  This study was carried out to assess the effects of the aqueous extract of Hyptis pectinata leaves on liver regeneration and on serum enzymes (AST, ALT and gamma-GT) after 67% partial hepatectomy in rats.
  
  
  METHODS
  AST, ALT and gamma-GT, were determined by conventional procedures using a spectrophotometer (Model E2250-CELM). Liver regeneration was evaluated by immunohistochemical staining for proliferating cell nuclear antigen (PCNA).
  
  
  RESULTS
  Oral pretreatment during 4 days at 100 mg/kg increased liver regeneration index. At 200 mg/kg, AST level was statistically decreased in comparison to the group submitted to distilled water administration. The other enzymes assessed disclosed no difference when all groups were compared.
  
  
  CONCLUSIONS
  The present study shows that the aqueous extract of Hyptis pectinata leaves contains some biological active principles that stimulate liver regeneration at 100 mg/kg and cause slight hepatic protection at 200 mg/kg.
authors.affiliation: Department of Medicine, Federal University of Sergipe, Brazil.
authors.forename: Gustavo Barreto
authors.initials: GB
authors.lastname: Melo
authors.forename: Renata Lemos
authors.initials: RL
authors.lastname: Silva
authors.forename: Valdinaldo Aragão
authors.initials: VA
authors.lastname: Melo
authors.forename: Angelo Roberto
authors.initials: AR
authors.lastname: Antoniolli
authors.forename: Paulo Roberto Teixeira
authors.initials: PR
authors.lastname: Michellone
authors.forename: Sérgio
authors.initials: S
authors.lastname: Zucoloto
authors.forename: Maria Eliza Jordani de
authors.initials: ME
authors.lastname: Souza
authors.forename: Maria Cecília Jordani
authors.initials: MC
authors.lastname: Gomes
authors.forename: Rodrigo Borges
authors.initials: RB
authors.lastname: Correia
authors.forename: Orlando de Castro e
authors.initials: Ode C
authors.lastname: Silva
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006498:Hepatectomy; D031331:Hyptis; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves; D028321:Plant Preparations / Q000627:therapeutic use*; D018809:Proliferating Cell Nuclear Antigen; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry; D018709:Statistics, Nonparametric; D000637:Transaminases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D010936:Plant Extracts; D028321:Plant Preparations; D018809:Proliferating Cell Nuclear Antigen; D005723:gamma-Glutamyltransferase; D000637:Transaminases