Context-sensitive half-time and anesthesia: how does theory match reality?
The pharmacokinetic model, which describes context-sensitive decrement times, has received validation through direct measurement. Further validation has come from the ability of targeted infusion schemes to obtain reliable and stable concentrations of a variety of intravenous drugs. A complete understanding of the concept will enable the appropriate selection of drugs and an appreciation of the strengths and limitations of current drug delivery systems.
Keifer
J
J
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA. keife001@mc.duke.edu
Glass
P
P