Induction of lesional and circulating leukocyte apoptosis by infliximab in a patient with moderate to severe psoriasis.
Infliximab demonstrates high efficacy in treating psoriasis in a high proportion of patients. In this report we demonstrate induction of plaque (T cells, dendritic cells) and peripheral blood (T cells, monocytes) leukocyte apoptosis following a single infliximab infusion in a psoriasis patient.
Malaviya
Rama
R
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08903-0019, USA. malaviya@earthlink.net
Sun
Yvonne
Y
Tan
Jennifer K
JK
Magliocco
Melissa
M
Gottlieb
Alice B
AB
D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D017209:Apoptosis; D003937:Diagnosis, Differential; D006801:Humans; D000069285:Infliximab; D007262:Infusions, Intravenous; D007962:Leukocytes; D008297:Male; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab