Issues related to targeted delivery of proteins and peptides.
While modern genomic and proteomic technology enables rapid screening of novel proteins and peptides as potential drug candidates, design of delivery systems for these biologics remains challenging especially to achieve site-specific pharmacological actions. This article discusses the issues associated with targeted delivery of protein and peptide drugs at physiochemical, physiological, and intracellular levels with a special focus on cancer therapy.
Lu
Yingjuan
Y
Endocyte, Inc, 3000 Kent Avenue, Suite A1-100, West Lafayette, IN 47906, USA. jlu@endocyte.com
Yang
Jun
J
Sega
Emanuela
E
D000818:Animals; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D010455:Peptides / Q000008:administration & dosage* / Q000145:classification; D011506:Proteins / Q000008:administration & dosage* / Q000145:classification
D004337:Drug Carriers; D010455:Peptides; D011506:Proteins