title: Thioredoxin-binding protein-2 (TBP-2): its potential roles in the aging process.
abstract: Thioredoxin (TRX) binding protein-2 (TBP-2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP-2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP-2 suppresses cellular proliferation along with cell cycle arrest at the G1 phase. TBP-2 was also reported to be a cellular senescence-associated gene. Besides the retardation of cellular growth, the reduction of white adipose, and alteration of the energy pathway are involved in several features of the aging process. We have generated TBP-2 genetically modified mice and found that TBP-2 is closely linked to lipid metabolism. Indeed, TBP-2 has been suggesting to be related to familial combined hyperlipidemia analyzed by a spontaneous mutant mouse strain. As lipid metabolism is one of the most primitive sources of energy production, we discussed the possible roles of TBP-2 in the regulation of energy utilization connected to the aging process.
authors.affiliation: Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara-cho Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yoshida
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kondo
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Oka
authors.forename: Md Kaimul
authors.initials: MK
authors.lastname: Ahsan
authors.forename: Tomijiro
authors.initials: T
authors.lastname: Hara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Masutani
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
authors.forename: Junji
authors.initials: J
authors.lastname: Yodoi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010084:Oxidation-Reduction; D013879:Thioredoxins
chemical_list: D002352:Carrier Proteins; C445672:Txnip protein, mouse; D013879:Thioredoxins