The importance of metrological traceability on the validity of creatinine measurement as an index of renal function.
The glomerular filtration rate (GFR) is currently considered the best overall index of kidney function. The possibility that laboratories might routinely report an estimated GFR has become practically feasible with the development of a formula, the "four-variable" Modification of Diet in Renal Disease study (MDRD) equation that uses age, sex, race, and serum creatinine parameters. However, a limitation of this equation for general implementation in healthcare is related to the use of differently calibrated creatinine measurement procedures among laboratories. The only way to achieve universal implementation of the GFR prediction equation, with the associated clinical benefits for patients, is, therefore, to promote worldwide standardization of methods to determine creatinine, together with the introduction of a revised GFR-estimating equation appropriate for use with standardized creatinine methods.
Cattedra di Biochimica Clinica e Biologia Molecolare Clinica, Dipartimento di Scienze Cliniche "Luigi Sacco", Università degli Studi di Milano, Milan, Italy.
Panteghini
Mauro
M
Myers
Gary L
GL
Miller
W Greg
WG
Greenberg
Neil
N
D002250:Carbon Radioisotopes; D003404:Creatinine / Q000097:blood*; D019937:Diagnostic Techniques and Procedures / Q000592:standards*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D011237:Predictive Value of Tests; D012015:Reference Standards; D015203:Reproducibility of Results
D002250:Carbon Radioisotopes; D003404:Creatinine