title: In vivo glucose measurement by surface-enhanced Raman spectroscopy.
abstract: This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague-Dawley rat such that the glucose concentration of the interstitial fluid could be measured by spectroscopically addressing the sensor through an optical window. The sensor had relatively low error (RMSEC = 7.46 mg/dL (0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Stuart
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Yuen
authors.forename: Nilam
authors.initials: N
authors.lastname: Shah
authors.forename: Olga
authors.initials: O
authors.lastname: Lyandres
authors.forename: Chanda R
authors.initials: CR
authors.lastname: Yonzon
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Glucksberg
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Walsh
authors.forename: Richard P
authors.initials: RP
authors.lastname: Van Duyne
mesh_terms: D000818:Animals; D004563:Electrochemistry; D005947:Glucose / Q000032:analysis* / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods*; D013499:Surface Properties; D013997:Time Factors
chemical_list: D005947:Glucose