title: [Effects of acupuncture on expressions of transcription factors NF-E2, YB-1, LRG47 in the SAMP10 mouse].
abstract: OBJECTIVE
  To explore the mechanism of acupuncture in delaying aging.
  
  
  METHODS
  Using SAMP10 mice and normal control SAMR1 as model and applying RT-PCR and DIG probed Northern blot techniques to observe expression of NF-E2, YB-1, LRG47 genes in whole brain, cortex and hippocampus in the 8-month SAMR1 control group, 8-month SAMP10 control group, 8-month SAMP10 acupuncture group and 8-month SAMP10 non-point acupuncture group.
  
  
  RESULTS
  In the SAMP10 control group, the expression of NF-E2, YB-1 and LRG47 were down-regulated in the whole brain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal.
  
  
  CONCLUSIONS
  Aging of the SAMP10 mouse brain is related with expression of NF-E2, YB-1 and LRG47 genes, and acupuncture can regulate the expression of NF-E2, YB-1 and LRG47 genes, improving the functions of erythrocyte series, increasing proliferation of cells and immune function of cells in anti-bacteria, hence anti-aging.
authors.affiliation: First Teaching Hospital of Tianjin TCM College, Tianjin 300193, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Yu
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Ding
authors.forename: Jing-xian
authors.initials: JX
authors.lastname: Han
mesh_terms: D015670:Acupuncture Therapy; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D050984:NF-E2 Transcription Factor, p45 Subunit / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D051840:Y-Box-Binding Protein 1 / Q000235:genetics*
chemical_list: C096000:Ifi1 protein, mouse; D050984:NF-E2 Transcription Factor, p45 Subunit; C494693:Nfe2 protein, mouse; D012333:RNA, Messenger; D051840:Y-Box-Binding Protein 1; D019204:GTP-Binding Proteins