Surgical management of acute necrotizing lung infections.
BACKGROUND
Surgical resection for acute necrotizing lung infections is not widely accepted due to unclear indications and high risk.


OBJECTIVE
To review results of resection in the setting of acute necrotizing lung infections.


METHODS
A retrospective review of patients who underwent parenchymal resection between January 1, 2000, and January 1, 2006, for management of necrotizing pneumonia or lung gangrene.


RESULTS
Thirty-five patients underwent resection for lung necrosis. At the time of consultation, all patients presented with pulmonary sepsis, and also had the following: empyema (n = 17), hemoptysis (n = 5), air leak (n = 7), septic shock requiring pressors (n = 8) and inability to oxygenate adequately (n = 7). Twenty-four patients were ventilated preoperatively. Eleven patients had frank lobar gangrene, and the other patients had combinations of necrotizing pneumonia and abscesses. In 10 patients, preresection procedures were performed, including percutaneous drainage of an abscess (n = 4), thoracoscopic decortication (n = 4) and open decortication (n = 2). Procedures included pneumonectomy (n = 4), lobectomy (n = 18), segmentectomy (n = 2), wedge resection (n = 4) and debridement (n = 7). There were three (8.5%) postoperative deaths--two due to multiple organ failure and one due to anoxic brain injury. All patients not ventilated preoperatively were weaned from ventilatory support within three days. Of those ventilated preoperatively, three died, while four remained chronically ventilator dependent.


CONCLUSIONS
Surgical resection for necrotizing lung infections is a reasonable option in patients with persistent sepsis who are failing medical therapy. Ventilated patients have a worse prognosis but can still be candidates for resection. Patients who are hemodynamically unstable appear to have better outcomes if they can be stabilized before resection.
Reimel
Beth Ann
BA
Department of Surgery, Harborview Medical Center, Seattle, USA.
Krishnadasen
Baiya
B
Cuschieri
Joseph
J
Klein
Matthew B
MB
Gross
Joel
J
Karmy-Jones
Riyad
R
D000208:Acute Disease; D005734:Gangrene; D006801:Humans; D008168:Lung / Q000473:pathology*; D009336:Necrosis; D011013:Pneumonectomy; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome