title: [Progress in research of chitosan as a non-viral gene delivery vector].
abstract: Efficiency of non-viral gene delivery based on chitosan and chitosan derivatives as DNA condensing carrier is dependent on a series of factors, such as complex size, the charge ratio of chitosan/DNA, molecular mass of chitosan, the degree of chitosan deacetylation, pH and serum concentration of the transfection medium. Through modifying the chitosan in a certain extent, we can change the efficiency of transfection. Studies on transfection condition, efficiency and mechanism using chitosan and chitosan derivatives as transfection agents are reviewed.
authors.affiliation: Biomedicine R&D Center, Jinan University, Guangzhou 510632, China. shsh589@163.com
authors.forename: Hui-Shuang
authors.initials: HS
authors.lastname: Su
authors.forename: Yi-Fei
authors.initials: YF
authors.lastname: Wang
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D005822:Genetic Vectors; D006801:Humans; D010957:Plasmids / Q000378:metabolism; D014162:Transfection / Q000379:methods*
chemical_list: D004247:DNA; D048271:Chitosan