title: Synthesis of 5-alkylidene-1,3-dioxane-4,6-diones, an easily accessible family of axially chiral alkenes: preparation in non-racemic form and platinum binding studies.
abstract: A general synthetic route to 5-alkylidene-1,3-dioxane-4,6-diones, which are a family of axially chiral alkenes, is described. Conformational issues are explored and the platinum-binding properties of these species are discussed. That these alkenes exist as stable enantiomers is established by their partial kinetic resolution upon reaction with cysteine.
authors.affiliation: Department of Chemistry, Cardiff University, Park Place, Cardiff, Wales/Cymru, UK CF10 3TB.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Casadesus
authors.forename: Michael P
authors.initials: MP
authors.lastname: Coogan
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Ooi