Ortho-arylation of benzamides.
[reaction: see text] A simple method for the direct ortho-arylation of benzoic acid amides has been developed. The palladium-catalyzed reactions proceed in trifluoroacetic acid and require the presence of stoichiometric silver acetate. This presents an alternative to the currently used ortho-lithiation strategies for the synthesis of arylated benzoic acid derivatives.
Shabashov
Dmitry
D
Department of Chemistry, University of Houston, Houston, Texas 77204, USA.
Daugulis
Olafs
O