VISA--a pass to innate immunity.
Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.
Qi
BaoChang
B
Harbin Medical University, Harbin 150086, China.
Huang
Yue
Y
Rowe
Dominic
D
Halliday
Glenda
G
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000276:immunology*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D050838:Interferon Regulatory Factor-3 / Q000276:immunology / Q000378:metabolism; D050839:Interferon Regulatory Factor-7 / Q000276:immunology / Q000378:metabolism; D007370:Interferon Type I / Q000235:genetics; D008928:Mitochondria / Q000276:immunology; D016328:NF-kappa B / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000276:immunology; D015398:Signal Transduction; D014779:Virus Replication; D014780:Viruses / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; D050838:Interferon Regulatory Factor-3; D050839:Interferon Regulatory Factor-7; D007370:Interferon Type I; D016328:NF-kappa B; D012330:RNA, Double-Stranded; C505371:MAVS protein, human; C512612:MAVS protein, mouse