title: High-spatial-resolution multistation MR angiography with parallel imaging and blood pool contrast agent: initial experience.
abstract: The purpose of this study was to prospectively evaluate the diagnostic accuracy of reader detection of 75% or greater stenosis at high-spatial-resolution multistation magnetic resonance (MR) angiography performed with matrix coils and a blood pool contrast agent. Ten healthy volunteers and 10 patients were examined. All participants provided informed consent to participate in this institutional review board-approved study. For contrast agent-enhanced multistation MR angiography, an albumin-binding gadolinium chelate, gadofosveset trisodium, was used. Imaging was performed during the first-pass and steady-state phases of the contrast agent. Vessel conspicuity on the first-pass MR angiograms obtained in both volunteers and patients was rated as excellent for 93% of vessels. At steady-state imaging, vessel conspicuity was rated as excellent or good for 89% of vessels. Gadofosveset trisodium-enhanced MR angiography yielded sensitivities of 100% and 97% and specificities of 96% and 97% for detection of significant disease in the carotid and lower extremity arteries, respectively.
authors.affiliation: Department of Clinical Radiology, Ludwig-Maximilians University of Munich, Grosshadern Campus, Marchioninistr 15, 81377 Munich, Germany. Konstantin.Nikolaou@med.uni-muenchen.de
authors.forename: Konstantin
authors.initials: K
authors.lastname: Nikolaou
authors.forename: Harald
authors.initials: H
authors.lastname: Kramer
authors.forename: Christina
authors.initials: C
authors.lastname: Grosse
authors.forename: Dirk
authors.initials: D
authors.lastname: Clevert
authors.forename: Olaf
authors.initials: O
authors.lastname: Dietrich
authors.forename: Mike
authors.initials: M
authors.lastname: Hartmann
authors.forename: Paul
authors.initials: P
authors.lastname: Chamberlin
authors.forename: Stefan
authors.initials: S
authors.lastname: Assmann
authors.forename: Maximilian F
authors.initials: MF
authors.lastname: Reiser
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
mesh_terms: D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D003287:Contrast Media; D005682:Gadolinium; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D005682:Gadolinium; C109932:gadofosveset trisodium