title: Regulation of ENaCs by proteases: An increasingly complex story.
abstract: Proteolytic processing of epithelial Na+ channel (ENaC) subunits has an important role in the regulation of ENaC gating. This Commentary addresses the potential roles of specific proteases and protease inhibitors in the control of Na+ channel gating.
authors.affiliation: Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. kleyman@pitt.edu
authors.forename: T R
authors.initials: TR
authors.lastname: Kleyman
authors.forename: M M
authors.initials: MM
authors.lastname: Myerburg
authors.forename: R P
authors.initials: RP
authors.lastname: Hughey
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000502:physiology*; D000818:Animals; D053503:Epithelial Sodium Channels; D005260:Female; D015640:Ion Channel Gating / Q000502:physiology; D051379:Mice; D009865:Oocytes / Q000502:physiology; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors; D058255:Protease Nexins; D011956:Receptors, Cell Surface / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology; D015222:Sodium Channels / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D014981:Xenopus; D000099271:Prostasin
chemical_list: D016564:Amyloid beta-Protein Precursor; D053503:Epithelial Sodium Channels; D010447:Peptide Hydrolases; D011480:Protease Inhibitors; D058255:Protease Nexins; D011956:Receptors, Cell Surface; D012697:Serine Endopeptidases; D015222:Sodium Channels; D000099271:Prostasin