title: A prospective survey of human herpesvirus-6 primary infection in solid organ transplant recipients.
abstract: Human herpesvirus 6 (HHV-6) infection is potentially life-threatening to immunosuppressed patients. There is a lack of information regarding the risk and the clinical manifestations of primary HHV-6 infection in solid-organ transplant recipients. We prospectively evaluated patients undergoing solid organ transplantation with negative immunoglobulin (Ig) G antibodies against HHV-6 by means of HHV-6 quantitative polymerase chain reaction. Among 193 recipients, seven were HHV-6 seronegative (prevalence 3.6%). We detected a positive HHV-6 viral load in only one patient, and four patients seroconverted after one year posttransplantation. The patient with a positive HHV-6 viral load developed cholestatic hepatitis without fever and did not experience severe end-organ disease. In conclusion, our findings show a low incidence of symptomatic primary HHV-6 infection among seronegative solid-organ transplant recipients.
authors.affiliation: Department of Infectious Diseases, Hospital Clínic-IDIBAPS, Barcelona, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cervera
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Marcos
authors.forename: Laura
authors.initials: L
authors.lastname: Linares
authors.forename: Eulalia
authors.initials: E
authors.lastname: Roig
authors.forename: Natividad
authors.initials: N
authors.lastname: Benito
authors.forename: Tomás
authors.initials: T
authors.lastname: Pumarola
authors.forename: Asunción
authors.initials: A
authors.lastname: Moreno
mesh_terms: D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000009:adverse effects; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D016035:Pancreas Transplantation / Q000009:adverse effects; D011183:Postoperative Complications / Q000821:virology*; D019349:Roseolovirus Infections / Q000453:epidemiology*; D013030:Spain; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents