The molecular basis of colorectal carcinogenesis.
The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing the role of four genes, APC, Cox-2, DCC/Smad4, and the mismatch repair genes, in colorectal carcinogenesis.
Shattuck-Brandt
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Department of Cell Biology and Medicine, Division of Gastroenterology, Vanderbilt University Medical School, MCN C-2104, 1161 21st Avenue South, Nashville, TN 37232, USA.
DuBois
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RN