Postnatal onset cortical dysplasia associated with infarction of white matter.
On MRI at 35 weeks of a boy born at 25 weeks, focal disorganization of the cortex was observed near a frontal venous infarct developed in the first week. Disruption of the final steps of cell migration, injury to the subplate and/or disruption of corticospinal axons are possible mechanisms behind it. Preterms with white matter lesions at or below 25 weeks postconceptional age should be scrutinized for cortical dysplasia.
Govaert
Paul
P
Department of Neonatology, Sophia Children's Hospital, Rotterdam, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. paul.govaert3@pandora.be
Lequin
Maarten
M
Korsten
Alex
A
Swarte
Renate
R
Kroon
André
A
Barkovich
A James
AJ
D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008279:Magnetic Resonance Imaging; D008297:Male; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis / Q000000981:diagnostic imaging; D014463:Ultrasonography