Relationship between prevalent oral and cervical human papillomavirus infections in human immunodeficiency virus-positive and -negative women.
Human papillomavirus (HPV) is an etiologic agent for both oropharyngeal and cervical cancers, yet little is known about the interrelationship between oral and cervical HPV infections. Therefore, we compared the prevalences and type distributions of oral and cervical HPV infections and evaluated infection concordance in a cross-sectional study within the Women's Interagency HIV Study cohort. Oral rinse and cervical-vaginal lavage samples were concurrently collected from a convenience sample of 172 human immunodeficiency virus (HIV)-positive and 86 HIV-negative women. HPV genomic DNA was detected by PGMY09/11 L1 consensus primer PCR and type specified by reverse line blot hybridization for 37 HPV types and beta-globin. Only 26 of the 35 HPV types found to infect the cervix were also found within the oral cavity, and the type distribution for oral HPV infections appeared distinct from that for cervical infections (P<0.001). Oral HPV infections were less common than cervical infections for both HIV-positive (25.2% versus 76.9%, P<0.001) and HIV-negative (9.0% versus 44.9%, P<0.001) women. Oral HPV infections were more common among women with a cervical HPV infection than those without a cervical HPV infection (25.5% versus 7.9%, P=0.002). The majority of women (207; 93.7%) did not have simultaneous oral and cervical infections by the same HPV type; however, the number of women who did (14; 6.3%) was significantly greater than would be expected by chance (P=0.0002). Therefore, the oral and cervical reservoirs for HPV infection are likely not entirely independent of one another.
Fakhry
Carole
C
Johns Hopkins Medicine and Johns Hopkins Bloomberg School of Public Health, Cancer Research Building I, 1650 Orleans Street G91, Baltimore, MD 21231-1000, and The CORE Center at John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA.
D'souza
Gypsyamber
G
Sugar
Elizabeth
E
Weber
Kathleen
K
Goshu
Eleni
E
Minkoff
Howard
H
Wright
Rodney
R
Seaberg
Eric
E
Gillison
Maura
M
D002584:Cervix Uteri / Q000821:virology*; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D009055:Mouth / Q000821:virology*; D009059:Mouth Diseases / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D009693:Nucleic Acid Hybridization / Q000379:methods; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D002577:Uterine Cervical Diseases / Q000150:complications / Q000453:epidemiology* / Q000821:virology
D004279:DNA, Viral