Proliferative effect of the aqueous extract of Hyptis pectinata on liver regeneration after partial hepatectomy in rats.
OBJECTIVE
This study was carried out to assess the effects of the aqueous extract of Hyptis pectinata leaves on liver regeneration and on serum enzymes (AST, ALT and gamma-GT) after 67% partial hepatectomy in rats.


METHODS
AST, ALT and gamma-GT, were determined by conventional procedures using a spectrophotometer (Model E2250-CELM). Liver regeneration was evaluated by immunohistochemical staining for proliferating cell nuclear antigen (PCNA).


RESULTS
Oral pretreatment during 4 days at 100 mg/kg increased liver regeneration index. At 200 mg/kg, AST level was statistically decreased in comparison to the group submitted to distilled water administration. The other enzymes assessed disclosed no difference when all groups were compared.


CONCLUSIONS
The present study shows that the aqueous extract of Hyptis pectinata leaves contains some biological active principles that stimulate liver regeneration at 100 mg/kg and cause slight hepatic protection at 200 mg/kg.
Melo
Gustavo Barreto
GB
Department of Medicine, Federal University of Sergipe, Brazil.
Silva
Renata Lemos
RL
Melo
Valdinaldo Aragão
VA
Antoniolli
Angelo Roberto
AR
Michellone
Paulo Roberto Teixeira
PR
Zucoloto
Sérgio
S
Souza
Maria Eliza Jordani de
ME
Gomes
Maria Cecília Jordani
MC
Correia
Rodrigo Borges
RB
Silva
Orlando de Castro e
Ode C
D000818:Animals; D004195:Disease Models, Animal; D006498:Hepatectomy; D031331:Hyptis; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves; D028321:Plant Preparations / Q000627:therapeutic use*; D018809:Proliferating Cell Nuclear Antigen; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry; D018709:Statistics, Nonparametric; D000637:Transaminases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D010936:Plant Extracts; D028321:Plant Preparations; D018809:Proliferating Cell Nuclear Antigen; D005723:gamma-Glutamyltransferase; D000637:Transaminases