Antimicrobial effectiveness of furazolidone against metronidazole-resistant strains of Helicobacter pylori.
The occurrence of strains resistant to metronidazole is causing failure of the 4-drug regimen for eradication of Helicobacter pylori in the Islamic Republic of Iran. This study compared the in vitro efficacy of furazolidone with metronidazole, clarithromycin, amoxicillin and tetracycline in 70 H. pylori isolates from dyspeptic patients. Of the isolates, 33% were resistant to metronidazole but all were susceptible to furazolidone. Furazolidone could be considered as an appropriate substitute for metronidazole for H. pylori infections.
Safaralizadeh
R
R
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Siavoshi
F
F
Malekzadeh
R
R
Akbari
M R
MR
Derakhshan
M H
MH
Sohrabi
M R
MR
Massarrat
S
S
D000658:Amoxicillin / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001471:Barrett Esophagus / Q000188:drug therapy; D001706:Biopsy; D017291:Clarithromycin / Q000627:therapeutic use; D052978:Disk Diffusion Antimicrobial Tests; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D004942:Esophagitis, Peptic / Q000188:drug therapy; D005664:Furazolidone / Q000627:therapeutic use*; D005756:Gastritis / Q000188:drug therapy; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008795:Metronidazole; D018579:Patient Selection; D010437:Peptic Ulcer / Q000188:drug therapy; D011159:Population Surveillance; D015995:Prevalence; D013752:Tetracycline / Q000627:therapeutic use; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D008795:Metronidazole; D005664:Furazolidone; D000658:Amoxicillin; D013752:Tetracycline; D017291:Clarithromycin