Prevalence of HCV/HIV co-infection among haemophilia patients in Baghdad.
To estimate the seroprevalence of HCV infection among HIV-infected haemophiliacs and to demonstrate the most prevalent HCV genotype, 47 HIV-infected haemophilia patients were screened for anti-HCV antibodies. By performing polymerase chain reaction and DNA enzyme immunoassay, HCV-RNA was detected with subsequent genotyping. Seroprevalence of anti-HCV antibodies was 66.0%. Of 31 HCV/HIV co-infected patients, 21 (67.7%) had no history of blood transfusion. We detected 4 HCV genotypes: 1a, 1b, 4 and 4 mixed with 3a, HCV-1b being the most frequent. Contaminated factor VIII (clotting factor) could be responsible for disease acquisition.
Al-Kubaisy
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WA
Department of Community Medicine, Al-Nahrain University, Baghdad, Iraq. waqar_abd@yahoo.co.uk
Al-Naib
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KT
Habib
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MA
D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion / Q000706:statistics & numerical data; D002648:Child; D015897:Comorbidity; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D004340:Drug Contamination / Q000706:statistics & numerical data; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D015528:HIV Seroprevalence; D006467:Hemophilia A / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007124:Immunoenzyme Techniques; D007493:Iraq / Q000453:epidemiology; D008403:Mass Screening; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D014504:Urban Health / Q000706:statistics & numerical data*
D004279:DNA, Viral; D018937:Hepatitis C Antibodies