title: Determination of enantiomeric excess and concentration of unprotected amino acids, amines, amino alcohols, and carboxylic acids by competitive binding assays with a chiral scandium complex.
abstract: A practical UV-vis sensing method for enantioselective microanalysis of unprotected amino acids, amines, amino alcohols, and carboxylic acids in aqueous solution has been developed. Both concentration and enantiomeric composition of a wide range of chiral substrates can be determined with high accuracy by two simple competitive binding assays using a scandium complex derived from 1,8-bis(3-(3',5'-dimethylphenyl)-9-acridyl)naphthalene N,N'-dioxide.
authors.affiliation: Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Mei
authors.forename: Christian
authors.initials: C
authors.lastname: Wolf
mesh_terms: D000588:Amines / Q000032:analysis* / Q000737:chemistry; D000596:Amino Acids / Q000032:analysis* / Q000737:chemistry; D000605:Amino Alcohols / Q000032:analysis* / Q000737:chemistry; D001667:Binding, Competitive; D001681:Biological Assay; D002264:Carboxylic Acids / Q000032:analysis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000032:analysis* / Q000737:chemistry; D012538:Scandium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D014633:Valine / Q000032:analysis / Q000737:chemistry
chemical_list: D000588:Amines; D000596:Amino Acids; D000605:Amino Alcohols; D002264:Carboxylic Acids; D009942:Organometallic Compounds; D014633:Valine; D012538:Scandium