title: The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized study.
abstract: OBJECTIVE
  To compare the cleansing quality of polyethylene glycol electrolyte solution and sodium phosphate with different schedules of administration, and to evaluate whether the timing of the administration of bowel preparation affects the detection of polyps.
  
  
  METHODS
  One hundred and seventy-seven consecutive outpatients scheduled for colonoscopy were randomized in one of four groups to receive polyethylene glycol electrolyte solution or oral sodium phosphate with two different timing schedules. Quality of cleansing, polyp detection, and tolerance were evaluated.
  
  
  RESULTS
  Patients receiving polyethylene glycol or sodium phosphate on the same day as the colonoscopy, obtained good to excellent global cleansing scores more frequently than patients who received polyethylene glycol or sodium phosphate on the day prior to the procedure (P < 0.001). Flat lesions, but not flat adenomas, were more frequent in patients prepared on the same day (P = 0.02).
  
  
  CONCLUSIONS
  The quality of colonic cleansing and the detection of flat lesions are significantly improved when the preparation is taken on the day of the colonoscopy.
authors.affiliation: Servicio de Aparato Digestivo, Unidad de Endoscopia (10(a) Planta), Hospital Universitario de Canarias, C/Ofra s/n, 38320 La Laguna, Santa Cruz de Tenerife, Spain. parrablanco@hotmail.com
authors.forename: Adolfo
authors.initials: A
authors.lastname: Parra-Blanco
authors.forename: David
authors.initials: D
authors.lastname: Nicolas-Perez
authors.forename: Antonio
authors.initials: A
authors.lastname: Gimeno-Garcia
authors.forename: Begona
authors.initials: B
authors.lastname: Grosso
authors.forename: Alejandro
authors.initials: A
authors.lastname: Jimenez
authors.forename: Juan
authors.initials: J
authors.lastname: Ortega
authors.forename: Enrique
authors.initials: E
authors.lastname: Quintero
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D003111:Colonic Polyps / Q000175:diagnosis* / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000008:administration & dosage* / Q000009:adverse effects; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
chemical_list: D002400:Cathartics; D010710:Phosphates; D011092:Polyethylene Glycols; C018279:sodium phosphate