title: The chemokine receptor CXCR4 as a therapeutic target for several diseases.
abstract: CXCR4 is the receptor for a chemokine, CXCL12 (stromal cell-derived factor-1, SDF-1). The CXCL12-CXCR4 axis has been proven to be involved in several problematic diseases, including AIDS, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis (RA). Thus, CXCR4 is thought to be an important therapeutic target to overcome the above diseases. We have developed several specific CXCR4 antagonists.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan. tamamura.mr@tmd.ac.jp
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tamamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Fujii
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D019718:Receptors, CXCR4