title: Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group Report.
abstract: OBJECTIVE
  The National Heart, Lung, and Blood Institute convened an interdisciplinary working group of experts to develop recommendations for the assessment and treatment of depression in patients with coronary heart disease (CHD).
  
  
  METHODS
  Consensus of experts.
  
  
  RESULTS
  Our current recommendations are that the Beck Depression Inventory-I be employed for epidemiological studies of depression and CHD, that the Patient Health Questionnaire 2-item version be employed for screening for trial eligibility, that the Depression Interview and Structured Hamilton (DISH) be employed for diagnostic ascertainment for trial inclusion, and that the Hamilton rating scale, which is part of the DISH, be employed for both depression symptom reduction and the remission criterion in any trial. We further recommend that a randomized controlled trial be undertaken to determine whether selective serotonin reuptake inhibitors, psychotherapy, or combined treatment can reduce the risk of CHD events and mortality associated with depression in CHD patients.
  
  
  CONCLUSIONS
  This report summarizes the recommendations made by the working group and discusses the rationale for each recommendation, the strengths and weaknesses of alternative approaches to assessment and treatment, and the implications for future research in this area.
authors.affiliation: Department of Medicine, Columbia University College of Physicians and Surgeons, 622 W 168th St, PH9 Center, Room 941, New York, NY 10032, USA. kd2124@columbia.edu
authors.forename: Karina W
authors.initials: KW
authors.lastname: Davidson
authors.forename: David J
authors.initials: DJ
authors.lastname: Kupfer
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Bigger
authors.forename: Robert M
authors.initials: RM
authors.lastname: Califf
authors.forename: Robert M
authors.initials: RM
authors.lastname: Carney
authors.forename: James C
authors.initials: JC
authors.lastname: Coyne
authors.forename: Susan M
authors.initials: SM
authors.lastname: Czajkowski
authors.forename: Ellen
authors.initials: E
authors.lastname: Frank
authors.forename: Nancy
authors.initials: N
authors.lastname: Frasure-Smith
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Freedland
authors.forename: Erika S
authors.initials: ES
authors.lastname: Froelicher
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Glassman
authors.forename: Wayne J
authors.initials: WJ
authors.lastname: Katon
authors.forename: Peter G
authors.initials: PG
authors.lastname: Kaufmann
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Kessler
authors.forename: Helena C
authors.initials: HC
authors.lastname: Kraemer
authors.forename: K Ranga R
authors.initials: KR
authors.lastname: Krishnan
authors.forename: François
authors.initials: F
authors.lastname: Lespérance
authors.forename: Nina
authors.initials: N
authors.lastname: Rieckmann
authors.forename: David S
authors.initials: DS
authors.lastname: Sheps
authors.forename: Jerry M
authors.initials: JM
authors.lastname: Suls
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000523:psychology*; D002986:Clinical Trials as Topic / Q000379:methods / Q000592:standards; D003131:Combined Modality Therapy; D003863:Depression / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy; D003866:Depressive Disorder / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007406:Interview, Psychological; D008403:Mass Screening; D018579:Patient Selection; D011581:Psychological Tests; D011613:Psychotherapy; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors