title: Overcoming regioselectivity issues inherent in bis-Tröger's base preparation.
abstract: [structure: see text] Bis-Tröger's base derivatives are a new family of molecular tweezers. A major drawback to their study is a lack of commercially available precursors, ortho-nitrocarboxylic acids. A reverse synthetic strategy starting from known dinitrodicarboxylic acids, which circumvents this problem, is presented. Via this methodology regioisomeric bis-TB derivatives can be prepared selectively, using only common aromatic amines that are typically commercially available.
authors.affiliation: Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Technicka 5, 166 28 Praha 6, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Havlík
authors.forename: Vladimír
authors.initials: V
authors.lastname: Kral
authors.forename: Bohumil
authors.initials: B
authors.lastname: Dolenský