title: Pseudomonas aeruginosa LecB is involved in pilus biogenesis and protease IV activity but not in adhesion to respiratory mucins.
abstract: Pseudomonas aeruginosa expresses two lectins which are implicated in adhesion and biofilm formation. In this study, we demonstrate that P. aeruginosa LecB is involved in pilus biogenesis and proteolytic activity. Moreover, neither lectin was involved in adhesion to human tracheobronchial mucin. We infer that some of the ascribed functions are secondary effects on other systems rather than effects of the lectins themselves.
authors.affiliation: Department of Medicine, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.
authors.forename: Avinash
authors.initials: A
authors.lastname: Sonawane
authors.forename: Jeevan
authors.initials: J
authors.lastname: Jyot
authors.forename: Reuben
authors.initials: R
authors.lastname: Ramphal
mesh_terms: D001422:Bacterial Adhesion / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D018441:Biofilms / Q000254:growth & development; D002465:Cell Movement; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D037102:Lectins / Q000235:genetics / Q000502:physiology*; D009077:Mucins / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D020543:Proteome / Q000032:analysis; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D020545:Respiratory Mucosa / Q000378:metabolism / Q000382:microbiology
chemical_list: D001426:Bacterial Proteins; D037102:Lectins; D009077:Mucins; D020543:Proteome; D010447:Peptide Hydrolases; C030732:protease IV