Effect of ionic crosslinking on the drug release properties of chitosan diacetate matrices.
Chitosan diacetate (CDA) was prepared by alkylating the amino moieties of chitosan with mono-iodoacetic acid. Subsequently, CDA was cross-linked with Al3+, Zn2+, and Ca2+ ions to yield three ionotropically crosslinked polymeric matrices. These composite matrices were characterized employing infrared spectroscopy (IR) and differential scanning calorimetry (DSC). Subsequently, they were loaded with caffeine, as a model drug, and were assessed as sustained release carriers by evaluating their caffeine release profiles. Interestingly, only CDA-Zn2+ complex sustained the release of caffeine effectively in a zero-order manner. The drug release and thermal behavior of the tested matrices agree with the relative strength of the ionic or coordination character of the bonds. This, in turn, depends on the position of the complexing ions on the electrophilic softness/hardness scale.
Aiedeh
Khaled M
KM
Faculty of Pharmacy, University of Jordan, Queen Rania St., Amman 11942, Jordan. Aiedeh@ju.edu.jo
Taha
Mutasem O
MO
Al-Hiari
Yusuf
Y
Bustanji
Yasser
Y
Alkhatib
Hatim S
HS
D000478:Alkylation; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry; D002110:Caffeine / Q000737:chemistry; D002122:Calcium Chloride / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis*; D019807:Iodoacetic Acid / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D012995:Solubility; D013055:Spectrophotometry, Infrared; D017967:Zinc Compounds / Q000737:chemistry
D017607:Aluminum Compounds; D002712:Chlorides; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D017967:Zinc Compounds; D000077410:Aluminum Chloride; D002110:Caffeine; C016837:zinc chloride; D048271:Chitosan; D002122:Calcium Chloride; D019807:Iodoacetic Acid