title: [Pulmonary arterial hypertension].
abstract: Pulmonary arterial hypertension is a progressive and lethal disease for which there is no effective cure. In recent years, however, there has been a significant progress in the knowledge about the pathobiologic mechanisms involved in the characteristic vascular damage of this disease. Knowledge has evolved from the importance of the vasoconstriction component originally contemplated to the current concept of a preponderant abnormal (fibromuscular) proliferation. This conceptual evolution has resulted in new and attractive pharmacologic interventions in an attempt to interrupt this abnormal process of vascular remodeling. In this review, the interventions derived from this pathobiologic knowledge are analyzed and based on the most recent controlled clinical trials; an evidence-based therapeutic strategy is established.
authors.affiliation: Departamento de Cardioneumología del Instituto Nacional de Cardiología Ignacio Chávez, México, Tlalpan, México. julio.sandoval@cardiologia.org.mx
authors.forename: Julio
authors.initials: J
authors.lastname: Sandoval Zárate
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000628:therapy