Complete assignments 1H and 13C NMR spectral data of four anabaseine derivatives.
The anabaseine derivatives 6-methoxy-7-hydroxy-1-(pyridin-3-yl)-3,4-dihydroisoquinoline, 6,7-dimethoxy-1-(pyridin-3-yl)-1,2,3,4-tetrahydroisoquinoline and 6,7-dimethoxy-1-(piperidin-3-yl)-1,2,3,4-tetrahydroisoquino- line were prepared either by demethylation with HBr or by reduction with different reagents, NaBH4 and H2/PtO2 from 6,7-dimethoxy-1-(pyridin-3-yl)-3,4-dihydroisoquinoline, as starting material. The structures have been fully assigned by the combination of one- and two-dimensional experiments.
Sobarzo-Sánchez
Eduardo
E
Department of Organic Chemistry and C.S.I.C. Associated Unit, Faculty of Chemistry, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain. esobarzo@usc.es
De la Fuente
Julio
J
Quezada
Elías
E
Castedo
Luis
L
D000691:Anabasine / Q000031:analogs & derivatives* / Q000737:chemistry; D002247:Carbon Isotopes / Q000032:analysis; D006859:Hydrogen / Q000032:analysis; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*
C522466:6,7-dimethoxy-1-(piperidin-3-yl)-1,2,3,4-tetrahydroisoquinoline; C522465:6,7-dimethoxy-1-(pyridin-3-yl)-1,2,3,4-tetrahydroisoquinoline; C522464:6-methoxy-7-hydroxy-1-(pyridin-3-yl)-3,4-dihydroisoquinoline; D002247:Carbon Isotopes; D007546:Isoquinolines; D011725:Pyridines; D006859:Hydrogen; C091713:anabaseine; D000691:Anabasine