title: [Prevention of osteoporosis by foods and dietary supplements. Soybean isoflavone and bone metabolism].
abstract: Soybean isoflavones show structural similarity to estradiol and therefore are known as phytoestrogen. Recently, isoflavones have received a great deal of attention for their preventive roles against hormone dependent diseases including postmenopausal osteoporosis, hyperlipidemia and cancer. Particularly, a number of studies have reported that soybean isoflavones inhibited bone loss in both female and male osteoporotic animal models as well as in postmenopausal women. On the other hand, since a kind of tablet with concentrated isoflavones has been recently applied for foods for specified health use (FOSHU), which are functional foods permitted to label a health claim by the Ministry of Health, Labor and Welfare in Japan, Food Safety Commission submitted a report the upper limit of daily isoflavone aglycon intake from FOSHU as well as from soybean products. This report demonstrates the effects of isoflavones on bone metabolism and safety.
authors.affiliation: National Institute of Health and Nutrition, Program of Nutritional Epidemiology, Project for Bio-index.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ishimi
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy; D048789:Phytoestrogens / Q000032:analysis / Q000494:pharmacology*; D017698:Postmenopause; D013025:Glycine max / Q000737:chemistry*
chemical_list: D007529:Isoflavones; D048789:Phytoestrogens