title: Timing of co-phenylcaine administration before rigid nasendoscopy: a randomized, controlled trial.
abstract: Rigid nasendoscopy is a commonly used method of examining the nasal cavity and postnasal space. Co-phenylcaine is useful for its vasoconstrictive and anaesthetic properties, but the length of time allowed for it to take effect is variable. We performed a single-blind, randomized, controlled trial to determine whether it was better to allow one or 10 minutes for co-phenylcaine to take effect. Fifty patients were randomized into two groups, 25 in each. Patients in the 10 minute group experienced less discomfort (p=0.02) and less pain (p=0.018) than those in the one minute group. Ease of examination was also greater in the 10 minute group, as was the quality of the image obtained (p<0.001).
authors.affiliation: Department of ENT, Royal United Hospital, Bath, UK. email@davepothier.com
authors.forename: D D
authors.initials: DD
authors.lastname: Pothier
authors.forename: C E J
authors.initials: CE
authors.lastname: Hall
authors.forename: S
authors.initials: S
authors.lastname: Gillett
authors.forename: P
authors.initials: P
authors.lastname: Nankivell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D014663:Nasal Decongestants / Q000008:administration & dosage*; D010147:Pain Measurement; D010656:Phenylephrine / Q000008:administration & dosage*; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D014663:Nasal Decongestants; D010656:Phenylephrine; D008012:Lidocaine