The role of neuropeptides in psoriasis.
The pathogenesis of psoriasis is incompletely understood but cutaneous neurogenic inflammation is probably involved. This involvement is suggested by a number of clinical and histological observations. Reports about the distribution of cutaneous nerves and the quantification of nerve growth factor and neuropeptides, including calcitonin gene-related peptide and vasoactive intestinal peptide, in lesional and nonlesional psoriatic skin suggest that sensory neuropeptides contribute to the development of psoriasis. This review summarizes what is known about the role of neurogenic markers in psoriasis.
Saraceno
R
R
Dermatology Centre, Hope Hospital, The University of Manchester, Salford, Manchester M6 8HD, UK.
Kleyn
C E
CE
Terenghi
G
G
Griffiths
C E M
CE
D015740:Calcitonin Gene-Related Peptide / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D011565:Psoriasis / Q000209:etiology / Q000503:physiopathology*; D013373:Substance P / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
D009414:Nerve Growth Factors; D009479:Neuropeptides; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide