title: Forecasting the unresponsiveness to verbal command on the basis of EEG frequency progression during anesthetic induction with propofol.
abstract: The objective of this study is to model the association between the electroencephalogram (EEG) spectral features and the novel r scale representing the sedative effects of the propofol anesthetic drug. On the basis of the r scale, the unresponsiveness to the verbal command (LVC) is forecasted. EEG recordings are taken from a 16-patient study population undergoing propofol anesthetic induction. EEG was filtered into consecutive 4-Hz passbands up to 28 Hz. Of these time-series, the amplitude envelopes were extracted and used as input features to the first and the second-order polynomial multiple linear regression models. The values r epsilon [0.4, 1] were predicted with the R2 value of 0.775 with a cross validation. The LVC times were forecasted with the median error of 5%-7% or equivalently 10-13 s. In contrast, using the median of the measured LVC times of the training population as a forecast, the corresponding error was 12% or 26 s. The results suggest an acceptable correlation between the r scale and the EEG spectrum in the studied range. Moreover, the r values of an individual can be predicted using a population model. The suggested framework enables forecasting the LVC, which may open new possibilities for steering the drug administration.
authors.affiliation: Department of Electrical and Information Engineering, University of Oulu, FIN-90014 Oulu, Finland. miika.koskinen@ee.oulu.fi
authors.forename: Miika
authors.initials: M
authors.lastname: Koskinen
authors.forename: Seppo
authors.initials: S
authors.lastname: Mustola
authors.forename: Tapio
authors.initials: T
authors.lastname: Seppäinen
mesh_terms: D000328:Adult; D000465:Algorithms; D000758:Anesthesia / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001307:Auditory Perception / Q000187:drug effects / Q000502:physiology; D003243:Consciousness / Q000187:drug effects* / Q000502:physiology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol