Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis.
OBJECTIVE
In the present study, we evaluated the anti-inflammatory activity of Poria cocos (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model.


METHODS
The anti-irritative effect of PoCo was evaluated with a visual score and quantified by non-invasive bioengineering methods, namely chromametry and transepidermal water loss. Three concentrations of PoCo in base cream DAC (amphiphilic emollient; German pharmacopoeia) were tested in a 4-day repetitive irritation test using SLS.


RESULTS
A statistically significant anti-inflammatory activity was observed for PoCo by all three methods when applied in parallel to the induction period of ICD. Application of PoCo after induction of ICD once a day for 5 days, starting just at the end of 4 days, was without any effect.


CONCLUSIONS
An anti-inflammatory efficacy of PoCo on the elicitation phase of the ICD induced by repeated SLS test could be observed and quantified by three independent, non-invasive biophysical assessment parameters. This effect can be explained by its influence on pro-inflammatory enzymes, namely phospholipase A2.
Fuchs
S M
SM
Department of Dermatology, Friedrich-Schiller-University Jena, Jena, Germany.
Heinemann
C
C
Schliemann-Willers
S
S
Härtl
H
H
Fluhr
J W
JW
Elsner
P
P
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification* / Q000627:therapeutic use*; D017453:Dermatitis, Irritant / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D020072:Polyporales / Q000737:chemistry*; D016037:Single-Blind Method; D012867:Skin / Q000187:drug effects; D012967:Sodium Dodecyl Sulfate; D013501:Surface-Active Agents; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate