[Correlation between the polymorphism of platelet glycoprotein GPIb α Kozak gene and transient ischemic attack].
OBJECTIVE
Genic susceptibility could increase the risk of transient ischemic attack (TIA). The objective of this study is to investigate the relationship between the polymorphism of platelet glycoprotein GPIb α Kozak gene and TIA in Qindao Han population.


METHODS
The polymorphisms of platelet glycoprotein GPIb α Kozak gene -5T/C in TIA patients and normal control were detected with sequence-specific primers polymerase chain reaction (PCR-SSP).


RESULTS
The prevalence of the CC genotype and C alleles were significantly higher in TIA patients than in the control group (P<0.05). The positive correlation between C allele and TIA was showed by logistic regression analysis (P=0.016).


CONCLUSIONS
The -5T/C polymorphism of the platelet glycoprotein GPIb α Kozak gene is implicated in the pathogenesis of TIA. C allele is an independent risk factor for TIA.
Song
Yu-qiang
YQ
Department of Neurology,the Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shangdong, 266003 PR China.
Zou
Hong-li
HL
Zhang
Chen
C
D000368:Aged; D000483:Alleles; D001483:Base Sequence; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D002546:Ischemic Attack, Transient / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D017422:Sequence Analysis, DNA
D019038:Platelet Glycoprotein GPIb-IX Complex