Studies on Nepalese crude drugs. XXIX. Chemical constituents of Dronapuspi, the whole herb of Leucas cephalotes SPRENG.
From the whole herb of Leucas cephalotes SPRENG., new labdane-, norlabdane- and abietane-type diterpenes named leucasdins A (1), B (2) and C (3), respectively, and two protostane-type triterpenes named leucastrins A (4) and B (5) were isolated, together with a known triterpene, oleanolic acid, five sterols, 7-oxositosterol, 7-oxostigmasterol, 7alpha-hydroxysitosterol, 7alpha-hydroxystigmasterol and stigmasterol, and eight flavones, 5-hydroxy-7,4'-dimethoxyflavone, pillion, gonzalitosin I, tricin, cosmosin, apigenin 7-O-beta-D-(6-O-p-coumaroyl)glucopyranoside, anisofolin A and luteolin 4'-O-beta-D-glucuronopyranoside. The structures of 1--5 were determined as (3S,6R,8R,9R,13S,16S)-9,13,15,16-bisepoxy-3,16-diacetoxy-6-formyloxylabdane, (3S,6R)-3-acetoxy-6-formyloxy-iso-ambreinolide, (4R,9S,12R,13R)-12,13-dihydroxyabiet-7-en-18-oic acid, (3S,17S,20S,24S)-3,20-dihydroxy-24-methylprotost-25-en, and (3S,17S,20S,24S)-3,20,24-trihydroxyprotost-25-en respectively, based on spectral and chemical data.
Miyaichi
Yukinori
Y
Department of Pharmacognosy, Pharmaceutical Sciences, Hokuriku University, Kanazawa, Ishikawa, Japan. y-miyaichi@hokuriku-u.ac.jp
Segawa
Akiko
A
Tomimori
Tsuyoshi
T
D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008518:Medicine, East Asian Traditional; D008968:Molecular Conformation; D009390:Nepal; D010946:Plants, Medicinal / Q000737:chemistry*; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
D004224:Diterpenes; D014315:Triterpenes; C516185:leucastrin A; C516187:leucastrin B; C516186:leucastrin C