[Problems of prevalance and resistance of nosocomial Klebsiella pneumonia in hospitals of Russia].
Prevalence of Klebsiella pneumoniae among gramnegative pathogens of nosocomial infections in intensive care units of 33 hospitals of 22 towns in Russia was investigated. Antibiotic susceptibility and extended-spectrum beta-lactamase production were tested in 420 nosocomial K. pneumoniae isolates. Carbapenems (imipenem, meropenem and ertapenem) showed the highest activity. Extended-spectrum beta-lactamase production based on the phenotyping methods was revealed in 342 (81.4%) isolates. The maximum activity against the K. pneumoniae isolates producing extended-spectrum beta-lactamase was observed in imipenem and meropenem (no unsusceptible strains were isolated). 3.2% of the isolates was not susceptible to ertapenem. Differences in the activity of cefoperazone/sulbactam, amikacin, ciprofloxacin and levofloxacin against the extended-spectrum beta-lactamase producing isolates in various hospitals were recorded.
Riabkova
E L
EL
Reshed'ko
G K
GK
Agapova
E D
ED
Aleksandrova
I A
IA
Beloborodova
N V
NV
Vostrikova
T Iu
TIu
Zdzitovetskiĭ
D E
DE
Ivanova
S F
SF
Il'ina
V N
VN
Marusina
N E
NE
Multykh
I G
IG
Polikarpova
S V
SV
Skal'skiĭ
S V
SV
Suborova
T N
TN
Toropova
I A
IA
Turkutiukov
V B
VB
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006761:Hospitals; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D012426:Russia; D001618:beta-Lactamases / Q000032:analysis
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases