Synthesis of diverse analogues of Oenostacin and their antibacterial activities.
Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC(50) ranging from 0.49 to 0.67 microM as compared to Oenostacin (EC(50)=0.12 microM).
Srivastava
Vandana
V
Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, Kukrail Picnic Spot Road, Lucknow 226 015, India.
Darokar
Mahendra P
MP
Fatima
Atiya
A
Kumar
J K
JK
Chowdhury
Chinmay
C
Saxena
Hari Om
HO
Dwivedi
Gaurav R
GR
Shrivastava
Kunal
K
Gupta
Vivek
V
Chattopadhyay
S K
SK
Luqman
Suaib
S
Gupta
M M
MM
Negi
Arvind S
AS
Khanuja
Suman P S
SP
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D004305:Dose-Response Relationship, Drug; D062385:Hydroxybenzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D062385:Hydroxybenzoates; C517130:oenostacin