title: Plasma levels of basic fibroblast growth factor and vascular endothelial growth factor and their association with IgVH mutation status in patients with B-cell chronic lymphocytic leukemia.
abstract: The mutation status of genes encoding the variable region of immunoglobulin heavy chains (IgV(H)) is a strong predictor of disease progression and survival in B-cell chronic lymphocytic leukemia (B-CLL). We investigated whether there is an association between the concentration of both vascular endothelial growth factor and basic fibroblast growth factor and IgV(H) mutation status in 49 untreated B-CLL patients.
authors.forename: Lukás
authors.initials: L
authors.lastname: Smolej
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrys
authors.forename: Sona
authors.initials: S
authors.lastname: Peková
authors.forename: Jirí
authors.initials: J
authors.lastname: Schwarz
authors.forename: David
authors.initials: D
authors.lastname: Belada
authors.forename: Pavel
authors.initials: P
authors.lastname: Zák
mesh_terms: D016222:Fibroblast Growth Factor 2 / Q000097:blood* / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D027041:Somatic Hypermutation, Immunoglobulin / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000235:genetics
chemical_list: D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2