2-aminopyrimidine-4,6-diol as an efficient ligand for solvent-free copper-catalyzed N-arylations of imidazoles with aryl and heteroaryl halides.
Efficient and solvent-free copper-catalyzed N-arylations of imidazoles with aryl and heteroaryl halides have been demonstrated. In the presence of CuBr, 2-aminopyrimidine-4,6-diol, and TBAF (n-Bu4NF), a variety of imidazoles underwent the N-arylation reaction with aryl and heteroaryl halides smoothly in moderate to excellent yields. Noteworthy is that the reaction is conducted under solvent-free conditions.
Xie
Ye-Xiang
YX
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.
Pi
Shao-Feng
SF
Wang
Jian
J
Yin
Du-Lin
DL
Li
Jin-Heng
JH
D000438:Alcohols; D002384:Catalysis; D003300:Copper; D006846:Hydrocarbons, Halogenated; D007093:Imidazoles / Q000737:chemistry*; D008024:Ligands; D011743:Pyrimidines / Q000737:chemistry*
D000438:Alcohols; D006846:Hydrocarbons, Halogenated; D007093:Imidazoles; D008024:Ligands; D011743:Pyrimidines; C012180:2-aminopyrimidine; D003300:Copper