3-Hydroxypyrrolidines from epoxysulfonamides and dimethylsulfoxonium methylide.
N-Tosyl-protected 3-hydroxypyrrolidines are prepared by reaction of dimethylsulfoxonium methylide with readily available epoxysulfonamides.
Hodgson
David M
DM
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK OX1 3TA. david.hodgson@chem.ox.ac.uk
Fleming
Matthew J
MJ
Xu
Zhaoqing
Z
Lin
Changxue
C
Stanway
Steven J
SJ
D000577:Amides / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004852:Epoxy Compounds / Q000737:chemistry*; D006900:Hydroxylation; D000432:Methanol / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry*; D013454:Sulfoxides / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*
D000577:Amides; D001388:Aziridines; D004852:Epoxy Compounds; D011759:Pyrrolidines; D013454:Sulfoxides; D013455:Sulfur; D000432:Methanol