Association of interleukin-8 with hot flashes in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women.
OBJECTIVE
The purpose of this study was to identify serum cytokine concentrations in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women with hot flashes.


METHODS
Serum concentrations of 17 cytokines were simultaneously measured using a multiplexed human cytokine assay in 129 premenopausal, perimenopausal, and postmenopausal women and 50 bilateral oophorectomized women.


RESULTS
Serum IL-8 concentrations in midlife women and bilateral oophorectomized women with severe hot flashes were significantly higher than the concentrations in women without hot flashes and women with mild and moderate hot flashes. Serum macrophage inflammatory protein-1beta concentration in women with severe hot flashes was significantly higher than those in women without hot flashes and women with mild and moderate hot flashes.


CONCLUSIONS
Serum IL-8 concentrations in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women with hot flashes were significantly higher than those in women without hot flashes. IL-8 may be associated with peripheral vasodilation in women with hot flashes.
Yasui
Toshiyuki
T
Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. yasui@clin.med.tokushima-u.ac.jp
Uemura
Hirokazu
H
Tomita
Junko
J
Miyatani
Yuka
Y
Yamada
Masayo
M
Kuwahara
Akira
A
Matsuzaki
Toshiya
T
Maegawa
Masahiko
M
Tsuchiya
Naoko
N
Yuzurihara
Mitsutoshi
M
Takeda
Shuichi
S
Irahara
Minoru
M
D000328:Adult; D054407:Chemokine CCL4; D016207:Cytokines / Q000097:blood; D005260:Female; D019584:Hot Flashes / Q000097:blood* / Q000209:etiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood*; D019402:Macrophage Inflammatory Proteins / Q000097:blood; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects; D047648:Perimenopause / Q000097:blood*; D017698:Postmenopause / Q000097:blood*; D017697:Premenopause / Q000097:blood*
D054407:Chemokine CCL4; D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D019402:Macrophage Inflammatory Proteins