Solution structures of thiopeptide antibiotics.
A detailed NMR study of the thiopeptide amythiamicin D establishes its solution conformation and the presence of a single intramolecular hydrogen bond involving NH13 and O28, and also provides the first evidence for self-association of thiopeptides in solution.
Lewis
Richard J
RJ
AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire, UK LE11 5RH.
Hughes
Rachael A
RA
Alcaraz
Lilian
L
Thompson
Stewart P
SP
Moody
Christopher J
CJ
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006860:Hydrogen Bonding; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry; D011487:Protein Conformation; D012996:Solutions; D013844:Thiazoles / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D047028:Macrocyclic Compounds; D010456:Peptides, Cyclic; D012996:Solutions; D013844:Thiazoles; C088501:amythiamicin D