title: Allostatic load and clinical risk as related to sense of coherence in middle-aged women.
abstract: OBJECTIVE
  To investigate how physiologic dysregulation, in terms of allostatic load and clinical risk, respectively, relates to sense of coherence (SOC) in women with no previously diagnosed pathology.
  
  
  METHODS
  At baseline, 200 43-year-old women took part in a standardized medical health examination and completed a 3-item measure of SOC, which they completed again 6 years later. According to data from the medical examination, two different measures of physiologic dysregulation were calculated: a) a measure of allostatic load based on empirically derived cut points and b) a measure of clinical risk based on clinically significant cut points.
  
  
  RESULTS
  In line with the initial hypotheses, allostatic load was found to predict future SOC, whereas clinical risk did not. In addition to baseline SOC and nicotine consumption, allostatic load was strongly associated with a weak SOC at the follow-up.
  
  
  CONCLUSIONS
  The better predictive value of allostatic load to clinical risk indicates that focusing solely on clinical risk obscures patterns of physiologic dysregulation that influence future SOC.
authors.affiliation: Department of Psychology, Stockholm University and Centre for Health Equity Studies, Stockholm University/Karolinska Institutet, SE 106 91 Stockholm, Sweden. pls@psychology.su.se
authors.forename: Petra
authors.initials: P
authors.lastname: Lindfors
authors.forename: Olle
authors.initials: O
authors.lastname: Lundberg
authors.forename: Ulf
authors.initials: U
authors.lastname: Lundberg
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000375:Aging / Q000523:psychology*; D001290:Attitude; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002908:Chronic Disease / Q000453:epidemiology; D004198:Disease Susceptibility; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006304:Health Status; D006801:Humans; D008593:Menopause; D010366:Peak Expiratory Flow Rate; D010549:Personal Satisfaction; D010808:Physical Examination; D012306:Risk; D013312:Stress, Physiological / Q000453:epidemiology* / Q000523:psychology; D013315:Stress, Psychological / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology; D049629:Waist-Hip Ratio
chemical_list: D002784:Cholesterol; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin