title: Cardiorespiratory effects of desflurane in dogs given romifidine or medetomidine before induction of anesthesia with propofol.
abstract: The objective of this study was to evaluate the use of desflurane after induction of anesthesia with propofol in dogs sedated with romifidine or medetomidine. Each of 8 healthy dogs received intravenously, in random order, 3 preanesthetic protocols: romifidine, 40 microg/kg of body weight (BW) (R40); romifidine, 80 microg/kg BW (R80); and medetomidine, 10 microg/kg BW (MED). Cardiovascular and respiratory variables were recorded during the procedure. Time to extubation, time to sternal recumbency, and time to standing were also recorded. Heart rate and respiratory rate decreased significantly during sedation from baseline values, but there were no differences between the means for the 3 preanesthetic protocols. Mean values for heart rate, mean arterial blood pressure, systolic arterial pressure, diastolic arterial pressure, respiratory rate, tidal volume, arterial oxygen saturation, end-tidal CO2 level, pH, and arterial blood gas values during anesthesia were similar for the 3 protocols. The mean end-tidal desflurane concentration was significantly lower with the R80 protocol than with the R40 protocol. The mean time to extubation was significantly shorter with the R40 protocol than with the R80 and MED protocols.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Campus Universitario de Rabanales, Córdoba, Spain. pv1govir@uco.es
authors.forename: Rafael J
authors.initials: RJ
authors.lastname: Gómez-Villamandos
authors.forename: José I
authors.initials: JI
authors.lastname: Redondo
authors.forename: Eva M
authors.initials: EM
authors.lastname: Martín
authors.forename: Juan M
authors.initials: JM
authors.lastname: Domínguez
authors.forename: María M
authors.initials: MM
authors.lastname: Granados
authors.forename: Indalecio
authors.initials: I
authors.lastname: Ruiz
authors.forename: José M
authors.initials: JM
authors.lastname: Santisteban
mesh_terms: D000762:Anesthesia Recovery Period; D000777:Anesthetics / Q000008:administration & dosage*; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D018592:Cross-Over Studies; D000077335:Desflurane; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007093:Imidazoles / Q000008:administration & dosage; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D020926:Medetomidine / Q000008:administration & dosage; D010101:Oxygen Consumption; D015742:Propofol / Q000008:administration & dosage; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000777:Anesthetics; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C076257:romifidine; D000077335:Desflurane; D007530:Isoflurane; D020926:Medetomidine; D015742:Propofol