title: Nanostructured thermosensitive polymers with radical scavenging ability.
abstract: The thermosensitive [60]fullerene end-capped poly(N-isopropylacrylamide) was successfully synthesized by the reaction of C(60) with dithiobenzoate-terminated poly(N-isopropylacrylamide), which was prepared by reversible addition-fragmentation chain-transfer (RAFT) polymerization in the presence of azobisisobutyronitrile (AIBN). Its structure was determined by FTIR, UV/Vis, and carbon and proton NMR spectroscopy as well as by size exclusion chromatography (SEC). The novel fullerenated polymer retained the thermosensitivity of poly(N-isopropylacrylamide). Moreover, it is soluble in water and most of the common organic solvents. Interestingly, it was able to form nanoparticle clusters in methanol and exhibited significant radical scavenging ability in cell viability and metabolic activity tests with fibroblasts and NOR-3 radicals.
authors.affiliation: Department of Chemistry, Clark Atlanta University, 223 James P. Brawley DR SW, Atlanta, GA 30314, USA.
authors.forename: Guangchang
authors.initials: G
authors.lastname: Zhou
authors.forename: Issifu I
authors.initials: II
authors.lastname: Harruna
authors.forename: Weilie L
authors.initials: WL
authors.lastname: Zhou
authors.forename: Wilhelm K
authors.initials: WK
authors.lastname: Aicher
authors.forename: Kurt E
authors.initials: KE
authors.lastname: Geckeler
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002850:Chromatography, Gel; D005347:Fibroblasts / Q000187:drug effects; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D037741:Fullerenes / Q000737:chemistry; D051379:Mice; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009570:Nitriles / Q000737:chemistry; D009574:Nitro Compounds / Q000494:pharmacology; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000180:Acrylic Resins; D016166:Free Radical Scavengers; D037741:Fullerenes; D020030:Nitric Oxide Donors; D009570:Nitriles; D009574:Nitro Compounds; D011108:Polymers; C052970:poly-N-isopropylacrylamide; C061872:FK 409; C004526:azobis(isobutyronitrile); C069837:fullerene C60