Age at menopause predicts age at onset of Parkinson's disease.
We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.
Ragonese
Paolo
P
Dipartimento di Neuroscienze Cliniche, University of Palermo, Palermo, Italy.
D'Amelio
Marco
M
Callari
Graziella
G
Salemi
Giuseppe
G
Morgante
Letterio
L
Savettieri
Giovanni
G
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D010300:Parkinson Disease; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors