title: Maternal antibrain antibodies in autism.
abstract: Autism is a neurodevelopmental disorder of prenatal onset that is behaviorally defined. There is increasing evidence for systemic and neuroimmune mechanisms in children with autism. Although genetic factors are important, atypical prenatal maternal immune responses may also be linked to the pathogenesis of autism. We tested serum reactivity in 11 mothers and their autistic children, maternal controls, and several groups of control children, to prenatal, postnatal, and adult rat brain proteins, by immunoblotting. Similar patterns of reactivity to prenatal (gestational day 18), but not postnatal (day 8) or adult rat brain proteins were identified in autistic children, their mothers, and children with other neurodevelopmental disorders, and differed from mothers of normal children, normal siblings of children with autism and normal child controls. Specific patterns of antibody reactivity were present in sera from the autism mothers, from 2 to 18 years after the birth of their affected children and were unrelated to birth order. Immunoblotting using specific antigens for myelin basic protein (MBP) and glial acidic fibrillary protein (GFAP) suggests that these proteins were not targets of the maternal antibodies. The identification of specific serum antibodies in mothers of children with autism that recognize prenatally expressed brain antigens suggests that these autoantibodies could cross the placenta and alter fetal brain development.
authors.affiliation: Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA. zimmerman@kennedykrieger.org
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Zimmerman
authors.forename: Susan L
authors.initials: SL
authors.lastname: Connors
authors.forename: Karla J
authors.initials: KJ
authors.lastname: Matteson
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Lee
authors.forename: Harvey S
authors.initials: HS
authors.lastname: Singer
authors.forename: Julian A
authors.initials: JA
authors.lastname: Castaneda
authors.forename: David A
authors.initials: DA
authors.lastname: Pearce
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000917:Antibody Formation; D001321:Autistic Disorder / Q000276:immunology*; D001323:Autoantibodies; D001921:Brain / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D011247:Pregnancy
chemical_list: D001323:Autoantibodies; D009419:Nerve Tissue Proteins