Vaccination against bacterial gut infections.
Recent developments in the field of vaccination against gut-borne bacterial illness are reviewed, including the major pathogens such as salmonella, shigella, cholera and Escherichia coli. The approaches covered range from immunization with killed and live attenuated organisms to genetically detoxified toxin molecules and DNA vaccination and transgenic foods. Both homologous and heterologous responses to various organisms and vector technologies are discussed in murine, bovine and human models, and conclusions are drawn regarding their potential use in the development of safe, effective and economically viable vaccines.
Fielder
M
M
St George's Vaccine Institute, Division of Infectious Diseases, St George's Hospital Medical School, London, UK.
Lewis
D J
DJ