title: Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: Results from the Shanghai Women's Health Study.
abstract: We evaluated the associations of dietary intake of calcium, fiber and vitamins with colorectal cancer risk in a population-based prospective cohort study conducted among Chinese women in Shanghai. Subjects were recruited in urban Shanghai from March 1997 to May 2000. All subjects were interviewed in-person to obtain information on demographic and lifestyle factors and anthropometric measurement was conducted. Usual dietary intake, using a validated food frequency questionnaire was assessed at the baseline survey. After following a total of 73,314 women for a median of 5.74 years, 283 incident colorectal cancer cases were recorded. Excluding the first 2 years of follow-up, a high intake of calcium was associated with a decreased risk of colorectal cancer. Comparing the highest quintile of nutrients intake to the lowest, the adjusted relative risk for colorectal cancer was 0.6 (p value for trend = 0.023) for calcium. No apparent associations were found for fiber, total vitamin A, carotene, vitamins B1, B2, B3, C and E with colorectal cancer risk. Our results suggest that calcium may be protective against colorectal cancer development even at a lower consumption level compared to Western populations.
authors.affiliation: Department of Medicine, Center for Health Services Research and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232-2587, USA.
authors.forename: Aesun
authors.initials: A
authors.lastname: Shin
authors.forename: Honglan
authors.initials: H
authors.lastname: Li
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Gong
authors.initials: G
authors.lastname: Yang
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002136:Calcium, Dietary / Q000008:administration & dosage*; D002338:Carotenoids / Q000008:administration & dosage; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D004043:Dietary Fiber / Q000008:administration & dosage*; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D018977:Micronutrients / Q000008:administration & dosage*; D008875:Middle Aged; D009749:Nutrition Surveys; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014815:Vitamins / Q000008:administration & dosage; D016387:Women's Health
chemical_list: D002136:Calcium, Dietary; D004043:Dietary Fiber; D018977:Micronutrients; D014815:Vitamins; D002338:Carotenoids