An evidence-based, multidisciplinary approach to the clinical considerations, management, and surveillance of adrenal lesions in familial adenomatous polyposis: report of three cases.
Adrenal masses are commonly discovered incidentally in patients with familial adenomatous polyposis, and adrenal malignancies have been rarely reported. Individuals with familial adenomatous polyposis frequently undergo abdominal CT-scan examinations for surveillance or symptoms. Adrenal lesions often are detected unexpectedly and are thus becoming a common clinical problem in this population. Adrenal lesions encompass a heterogeneous spectrum of pathologic entities, including primary adrenocortical and medullary tumors, benign or malignant lesions, hormonally active or inactive lesions, metastases, and infections. When an adrenal mass is detected, the clinician needs to address two crucial questions: 1) is the mass malignant? and 2) is it hormonally active? This article presents three new cases of incidental adrenal lesions in familial adenomatous polyposis, reviews the medical literature for this setting, and provides an overview of the diagnostic clinical approach and management of the adrenal findings in familial adenomatous polyposis patients.
Ferrández
Angel
A
Department of Outreach and Prevention, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Pho
Lana
L
Solomon
Cindy
C
Samowitz
Wade S
WS
Kuwada
Scott K
SK
Knecht
Thomas P
TP
Gilfeather
Maryellyn
M
Burt
Randal W
RW
D015746:Abdominal Pain / Q000209:etiology; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D011125:Adenomatous Polyposis Coli / Q000150:complications*; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D000368:Aged; D001416:Back Pain / Q000209:etiology; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008297:Male; D014057:Tomography, X-Ray Computed