Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans.
The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-beta-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.
Bowman
J C
JC
Department of Infectious Disease Research, Merck Research Laboratories, RY80Y-260, P.O. Box 2000, Rahway, NJ 07065-0900, USA. joel_bowman@merck.com
Abruzzo
G K
GK
Flattery
A M
AM
Gill
C J
CJ
Hickey
E J
EJ
Hsu
M J
MJ
Kahn
J Nielsen
JN
Liberator
P A
PA
Misura
A S
AS
Pelak
B A
BA
Wang
T C
TC
Douglas
C M
CM
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001230:Aspergillus / Q000187:drug effects*; D001231:Aspergillus flavus / Q000187:drug effects*; D001233:Aspergillus nidulans / Q000187:drug effects*; D000077336:Caspofungin; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D054714:Echinocandins; D005260:Female; D055666:Lipopeptides; D051379:Mice; D008811:Mice, Inbred DBA; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000077336:Caspofungin