Plasma levels of basic fibroblast growth factor and vascular endothelial growth factor and their association with IgVH mutation status in patients with B-cell chronic lymphocytic leukemia.
The mutation status of genes encoding the variable region of immunoglobulin heavy chains (IgV(H)) is a strong predictor of disease progression and survival in B-cell chronic lymphocytic leukemia (B-CLL). We investigated whether there is an association between the concentration of both vascular endothelial growth factor and basic fibroblast growth factor and IgV(H) mutation status in 49 untreated B-CLL patients.
Smolej
Lukás
L
Andrys
Ctirad
C
Peková
Sona
S
Schwarz
Jirí
J
Belada
David
D
Zák
Pavel
P
D016222:Fibroblast Growth Factor 2 / Q000097:blood* / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D027041:Somatic Hypermutation, Immunoglobulin / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000235:genetics
D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2