title: Focal increased cortical density in immediate postembolization CT scans of patients with intracranial aneurysms.
abstract: OBJECTIVE
  Cortical hyperdensity was observed in the immediate postembolization CT scans of some patients with intracranial aneurysms following uneventful endovascular treatments. The clinical significance and possible underlying mechanism were evaluated.
  
  
  METHODS
  Ninety-three consecutive patients with a total of 100 intracranial aneurysms, treated by endosaccular packing, were studied. Seventy-four aneurysms were treated with balloon assistance, and the remaining aneurysms were treated without balloon assistance. All patients underwent cranial CT just before and immediately after the endovascular treatment. If the post-treatment CT showed any new finding, an immediate MR imaging and a repeat CT 4-6 hours after the initial posttreatment CT were performed. Several parameters were investigated related to the presence of cortical hyperdensity.
  
  
  RESULTS
  Cranial CT showed focal cortical hyperdensity following the treatment of 40/74 aneurysms (54%) with balloon remodeling and 9/26 aneurysms (34.6%) without balloon assistance. None of these patients were symptomatic, and cortical hyperdensity resolved in the repeat CT scans. A statistically significant relationship was observed between the presence of this finding and the total amount of contrast material, microcatheter time, number of balloon inflations, and total balloon inflation time.
  
  
  CONCLUSIONS
  Immediate postembolization CT may show focal cortical hyperdensity following uneventful endovascular aneurysm treatment, most likely caused by blood-brain barrier disruption resulting in accumulation of contrast medium. The hyperdensity was more frequent when balloon assistance was used but was also seen in the patients with no balloon use. It is important to differentiate this clinically insignificant finding from possible hemorrhage, which would affect patients' immediate postprocedural medical management.
authors.affiliation: Department of Radiology, Hacettepe University Hospitals, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ozturk
authors.forename: I
authors.initials: I
authors.lastname: Saatci
authors.forename: A G
authors.initials: AG
authors.lastname: Pamuk
authors.forename: C
authors.initials: C
authors.lastname: Erdogan
authors.forename: I
authors.initials: I
authors.lastname: Akmangit
authors.forename: S
authors.initials: S
authors.lastname: Geyik
authors.forename: H S
authors.initials: HS
authors.lastname: Cekirge
mesh_terms: D000800:Angioplasty, Balloon; D001812:Blood-Brain Barrier / Q000502:physiology; D002533:Cerebral Angiography; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004621:Embolization, Therapeutic; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging; D006801:Humans; D020766:Intracranial Embolism / Q000000981:diagnostic imaging / Q000628:therapy*; D011145:Polyvinyls / Q000008:administration & dosage; D011446:Prospective Studies; D019736:Prostheses and Implants; D012307:Risk Factors; D015607:Stents; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; C450660:Onyx copolymer; D011145:Polyvinyls; D004121:Dimethyl Sulfoxide