title: De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: successful treatment with autologous peripheral blood stem cell transplantation.
abstract: Basophils play an important role in allergic inflammation and are pathologically related to hematological disturbances, such as iron deficiency anemia and myeloproliferative disorders; however, they are only rarely encountered in lymphoid malignancies. Here, we report the case of a 33-year-old man with a bulky mass of the small intestine, multiple paraaortic lymphoadenopathy, pleural effusion, and ascites, who was diagnosed as a case of de novo CD5+ diffuse large B cell lymphoma (DLBCL). This patient showed a marked elevation of the basophil count in the peripheral blood, which appeared to run in parallel with the tumor burden. High dose chemotherapy followed by autologous peripheral blood cell transplantation yielded complete remission, and the patient has remained disease free for 5 years. To the best of our knowledge, this is the first report of a case of de novo CD5+ DLBCL showing marked elevation of the PB basophil count.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan. tokuhira@saitama-med.ac.jp
authors.forename: Michihide
authors.initials: M
authors.lastname: Tokuhira
authors.forename: Reiko
authors.initials: R
authors.lastname: Watanabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iizuka
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Sekiguchi
authors.forename: Tomoe
authors.initials: T
authors.lastname: Nemoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hanzawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takamatsu
authors.forename: Taro
authors.initials: T
authors.lastname: Maruyama
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Tamaru
authors.forename: Shinji
authors.initials: S
authors.lastname: Itoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Mori
mesh_terms: D000328:Adult; D001201:Ascites / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D044466:Asian People; D001491:Basophils / Q000473:pathology; D018956:CD5 Antigens; D006801:Humans; D007414:Intestinal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D007564:Japan; D016393:Lymphoma, B-Cell / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D016066:Pleural Effusion, Malignant / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011859:Radiography; D012074:Remission Induction; D014182:Transplantation, Autologous; D047368:Tumor Burden
chemical_list: D018956:CD5 Antigens