The expanding spectrum of Mycobacterium avium complex-associated pulmonary disease.
Nontuberculous mycobacteria (NTM) are increasingly recognized as important pulmonary pathogens. Mycobacterium avium intracellulare complex (MAC) causes most lung infections due to NTM. Patients with preexisting lung disease or immunodeficiency are at greatest risk for developing MAC infection. The majority of MAC pulmonary cases, however, occur in immunocompetent elderly women in association with nodular infiltrates and bronchiectasis. More recently, pulmonary disease has also been described in immunocompetent patients after exposure to MAC-contaminated hot tubs. We describe a case of aggressive MAC lung disease in a young immunocompetent female patient without preexisting lung disease whose clinical and pathologic characteristics do not fit into any of these categories and may represent a unique manifestation of MAC lung disease.
Waller
E Andrew
EA
Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, Department of Pulmonary Medicine, 4500 San Pablo Rd, Jacksonville, FL 32224, USA. waller.ernest@mayo.edu
Roy
Archana
A
Brumble
Lisa
L
Khoor
Andras
A
Johnson
Margaret M
MM
Garland
Jeffrey L
JL
D000328:Adult; D000583:Amikacin / Q000008:administration & dosage; D001706:Biopsy; D017291:Clarithromycin / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000008:administration & dosage; D005260:Female; D006099:Granuloma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D015269:Mycobacterium avium Complex / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009336:Necrosis; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage; D013183:Sputum / Q000382:microbiology; D014057:Tomography, X-Ray Computed
D000583:Amikacin; D004977:Ethambutol; D017291:Clarithromycin; D011241:Prednisone; D012293:Rifampin