title: B-type natriuretic peptide levels predict event-free survival in patients with implantable cardioverter defibrillators.
abstract: BACKGROUND
  We examined whether B-type natriuretic peptide (BNP) levels predict outcome in heart failure patients with implantable cardioverter defibrillators (ICD) using a combined endpoint of malignant tachyarrhythmias, death or heart transplantation.
  
  
  RESULTS
  BNP levels were measured in 123 ICD patients with chronic heart failure (age: 63+/-12 years, ejection fraction: 29+/-10%). After a median follow-up of 25 months, the combined endpoint was reached in 28 patients (first tachyarrhythmic event, n=16; death, n=11; heart transplantation, n=1). BNP levels were significantly lower in patients with event-free survival compared to patients reaching the combined endpoint of this study (median: 140 vs. 373 pg/ml; p<0.001). Multivariable Cox regression analysis revealed that BNP levels predict adverse outcome (RR 1.002 per pg/ml increment; 95% CI: 1.001-1.003; p<0.001) and use of beta-blockers was associated with favourable outcome (RR 0.319; 95% CI 0.151-0.670; p=0.004). LV ejection fraction (p=0.66) did not significantly predict event-free survival in multivariable analysis.
  
  
  CONCLUSIONS
  BNP plasma levels are useful markers to predict event-free survival in ICD patients with heart failure. Of note, malignant tachyarrhythmias appear responsible for about 50% of fatal outcomes. Our findings suggest that determination of BNP plasma levels is more valuable than determining LV ejection fraction to anticipate event-free survival in this population.
authors.affiliation: Klinik für Innere Medizin, Kardiologie, Germany. ChristMic@uhbs.ch <ChristMic@uhbs.ch>
authors.forename: Michael
authors.initials: M
authors.lastname: Christ
authors.forename: Julia
authors.initials: J
authors.lastname: Sharkova
authors.forename: Somer
authors.initials: S
authors.lastname: Bayrakcioglu
authors.forename: Ileana
authors.initials: I
authors.lastname: Herzum
authors.forename: Christian
authors.initials: C
authors.lastname: Mueller
authors.forename: Wolfram
authors.initials: W
authors.lastname: Grimm
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D017147:Defibrillators, Implantable; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain