title: Treatment of cervical intraepithelial neoplasia levels 2 and 3 with adapalene, a retinoid-related molecule.
abstract: OBJECTIVE
  This study examined dose scheduling, safety, and efficacy of adapalene in the treatment of CIN2 and CIN3.
  
  
  METHODS
  Patients were instructed on insertion and removal of an adapalene delivery system. Treatment regimens of 4, 8, and 14 days were utilized. Biopsies were performed on day 90 to assess efficacy. Safety was evaluated with toxicity questionnaires and patient interviews.
  
  
  RESULTS
  Two patients treated for 4 days had stable disease. Twenty-three patients treated for 8 days demonstrated an overall 61% (14 of 23) response rate. Twenty-four patients treated for 14 days had an overall 38% (9 of 24) response rate. No patient had disease progression. Compared to untreated historical controls, significantly improved efficacy was demonstrated for patients with CIN2. Patients with CIN3 had improved efficacy, though not statistically significant.
  
  
  CONCLUSIONS
  The lack of side effects and practicality of home use make adapalene a nontoxic and safe alternative to surgical therapy in patients with CIN2 and CIN3.
authors.affiliation: University of Oklahoma Health Science Center, Department of Obstetrics and Gynecology, Oklahoma City, Oklahoma, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: DiSilvestro
authors.forename: J M
authors.initials: JM
authors.lastname: DiSilvestro
authors.forename: W
authors.initials: W
authors.lastname: Lernhardt
authors.forename: M
authors.initials: M
authors.lastname: Pfahl
authors.forename: R S
authors.initials: RS
authors.lastname: Mannel