title: The therapeutic effect of tissue cultured root of wild Panax ginseng C.A. Mayer on spermatogenetic disorder.
abstract: This study examined the possibility of using a tissue cultured root of wild Panax ginseng (tcwPG) as a fertility agent. The effect of tcwPG on spermatogenesis was studied using male rats. The tcwPG crude powder was administered orally to 7-week-old rats over a 6-week period. The number of sperm in the testes and epididymides was significantly higher than the control. A histological examination did not reveal any morphological changes in the testes from the tcwPG powder treated rats. Moreover, there were no significant differences in the weights of the heart, spleen, liver, kidney, brain, testes and epididymides. Oligospermia was also induced by administering 2,3,7,8-tetrachlorodaibenzo-p-dioxin (TCDD) to the rats in order to estimate the feasibility of using tcwPG as treatment for infertility caused by spermatogenic disorders. After exposing the rats to TCDD, the tcwPG saponin fraction treated rats showed some improvement in the body weight, sperm number and testis morphology. It was estimated that tcwPG had feasibility as a therapeutic agent on spermatogenic disorder.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea.
authors.forename: Jeong Sook
authors.initials: JS
authors.lastname: Park
authors.forename: Seock Yeon
authors.initials: SY
authors.lastname: Hwang
authors.forename: Won Suk
authors.initials: WS
authors.lastname: Lee
authors.forename: Kee Won
authors.initials: KW
authors.lastname: Yu
authors.forename: Kee Yoeup
authors.initials: KY
authors.lastname: Paek
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Kun
authors.initials: K
authors.lastname: Han
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D036145:Ginsenosides / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D009845:Oligospermia / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D005894:Panax / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D000072317:Polychlorinated Dibenzodioxins; D011208:Powders; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000737:chemistry; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000473:pathology; D046509:Tissue Culture Techniques
chemical_list: D036145:Ginsenosides; D000072317:Polychlorinated Dibenzodioxins; D011208:Powders; D012503:Saponins