A facile synthesis of the basic steroidal skeleton using a Pauson-Khand reaction as a key step.
A high-yield synthesis of steroid-type molecules under mild reaction conditions is achieved in two steps involving nucleophilic addition of alkynyl cerium reagent to an easily enolizable carbonyl compound (beta-tetralone) followed by an intramolecular Pauson-Khand reaction.
Kim
Do Han
DH
Intelligent Textile System Research Center and Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
Kim
Kwang
K
Chung
Young Keun
YK