title: Molecular recognition based iron removal from human plasma with imprinted membranes.
abstract: The aim of this study is to prepare ion-imprinted poly(2-hydroxyethyl methacrylate) (HEMA) based membranes which can be used for the selective removal of Fe3+ ions from Fe3+-overdosed human plasma. N-methacryloyl-(L)-glutamic acid (MAGA) was chosen as the ion-complexing monomer. In the first step, Fe3+ was complexed with MAGA and then, the Fe3+-imprinted poly(HEMA-MAGA) membranes were prepared by UV-initiated photo-polymerization of HEMA and MAGA-Fe3+ complex in the presence of an initiator (benzoyl peroxide). After that, the template (i.e., Fe3+ ions) was removed by using 0.1 M EDTA solution at room temperature. The specific surface area of the Fe3+-imprinted poly(HEMA-MAGA) membranes was found to be 49.2 m2/g and the swelling ratio was 92%. According to the elemental analysis results, the polymeric membranes contained 145.7 micromol MAGA/g polymer. The maximum adsorption capacity was 164.2 micromol Fe3+/g membrane. The relative selectivity coefficients of ion-imprinted membranes for Fe3+/Zn2+ and Fe3+/Cr3+ were 12.6 and 62.5 times greater than the non-imprinted matrix, respectively. The Fe3+-imprinted poly(HEMA-MAGA) membranes could be used many times without decreasing their Fe3+ adsorption capacities significantly.
authors.affiliation: Department of Chemistry, Biochemistry Division, Hacettepe University, Ankara - Turkey. handany@hacettepe.edu.tr
authors.forename: H
authors.initials: H
authors.lastname: Yavuz
authors.forename: M
authors.initials: M
authors.lastname: Andaç
authors.forename: L
authors.initials: L
authors.lastname: Uzun
authors.forename: R
authors.initials: R
authors.lastname: Say
authors.forename: A
authors.initials: A
authors.lastname: Denizli
mesh_terms: D018698:Glutamic Acid / Q000031:analogs & derivatives; D006801:Humans; D007501:Iron / Q000097:blood*; D008567:Membranes, Artificial; D008689:Methacrylates; D016060:Sorption Detoxification / Q000379:methods*
chemical_list: D008567:Membranes, Artificial; D008689:Methacrylates; C115674:N-methacryloyl-glutamic acid; D018698:Glutamic Acid; C005044:hydroxyethyl methacrylate; D007501:Iron