[Effects of fluoxetine on locomotor activity: possible involvement of dopamine].
Plus-maze benavior of adult mail rats was assessed and contents of 5-hydroxyindoleacetic acid (5-HIAA) and dopamine (DA) in different brain regions were analyzed after two-week fluoxetine treatment (25 mg/kg/day, per os). Chronic fluoxetine treatment produced a general decrease in the brain 5-HIAA content and a decrease in DA content in the frontal cortex and striatum. Behaviorally, fluoxetine-treated animals displayed enhanced anxiety and decreased locomotor activity. The DA depletion os supposed to be responsible for fluoxetine-produced hypolocomotion. This is supported by a significant correlation between the dopamine content in the frontal cortex and the number of entries into the closed arms of the plus-maze. The results suggest that the hypolocomotor effect of fluoxetine may involve the changes in the dopaminergic system.
Shishkina
G T
GT
Iudina
A M
AM
Dygalo
N N
NN
D000818:Animals; D001923:Brain Chemistry; D004298:Dopamine / Q000032:analysis / Q000502:physiology*; D005473:Fluoxetine / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D004298:Dopamine; D005473:Fluoxetine; D006897:Hydroxyindoleacetic Acid; D017367:Selective Serotonin Reuptake Inhibitors