Fabrication and in vitro characterization of porous biodegradable composites based on phosphate glasses and oligolactide-containing polymer networks.
Degradable porous composite materials for use as temporary bone replacement or tissue engineering scaffolds were produced using a methacrylate-modified oligolactide polymer network and phosphate invert glasses in the system P2O5-CaO-MgO-Na2O-(TiO2). Porous glasses with an open interconnective porosity were produced by a salt sintering process. Compressive strengths were significantly enhanced by polymer coating of the inner surface of the porous glasses or by fabrication of glass powder-reinforced porous polymer specimens. In vitro degradation in simulated body fluid showed a degradation pattern of the composites which could be modulated by the composition and resulting solubility of the incorporated glass phase. Cytocompatibility of the composites was investigated in a FDA/EtBr viability assay using an MC3T3-E1 osteoblast-like cell line and showed good biocompatibility of the materials in vitro.
Brauer
Delia S
DS
Department of Preventive and Restorative Dental Sciences, University of California San Francisco, 707 Parnassus Avenue, San Francisco, California 94143, USA. delia.brauer@ucsf.edu
Rüssel
Christian
C
Vogt
Sebastian
S
Weisser
Jürgen
J
Schnabelrauch
Matthias
M
D016475:3T3 Cells; D020341:Absorbable Implants; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003188:Composite Resins / Q000737:chemistry* / Q000494:pharmacology; D005139:Eyeglasses; D020007:Implants, Experimental; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000166:cytology; D010710:Phosphates; D011091:Polyesters; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods
D003188:Composite Resins; D010710:Phosphates; D011091:Polyesters; C033616:poly(lactide)