title: Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa.
abstract: We assessed neutralizing antibody titers to adenovirus serotype 5 (Ad5) and six rare adenovirus serotypes, serotypes 11, 35, 50, 26, 48, and 49, in pediatric populations in sub-Saharan Africa. We observed a clear age dependence of Ad5-specific neutralizing antibody titers. These data will help to guide the development of Ad vector-based vaccines for human immunodeficiency virus type 1 and other pathogens.
authors.affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Research East, Room 213, 330 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Thorner
authors.forename: Ronald
authors.initials: R
authors.lastname: Vogels
authors.forename: Jorn
authors.initials: J
authors.lastname: Kaspers
authors.forename: Gerrit J
authors.initials: GJ
authors.lastname: Weverling
authors.forename: Lennart
authors.initials: L
authors.lastname: Holterman
authors.forename: Angelique A C
authors.initials: AA
authors.lastname: Lemckert
authors.forename: Athmanundh
authors.initials: A
authors.lastname: Dilraj
authors.forename: Lisa M
authors.initials: LM
authors.lastname: McNally
authors.forename: Prakash M
authors.initials: PM
authors.lastname: Jeena
authors.forename: Soren
authors.initials: S
authors.lastname: Jepsen
authors.forename: Peter
authors.initials: P
authors.lastname: Abbink
authors.forename: Anjali
authors.initials: A
authors.lastname: Nanda
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Swanson
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Bates
authors.forename: Kara L
authors.initials: KL
authors.lastname: O'Brien
authors.forename: Menzo J E
authors.initials: MJ
authors.lastname: Havenga
authors.forename: Jaap
authors.initials: J
authors.lastname: Goudsmit
authors.forename: Dan H
authors.initials: DH
authors.lastname: Barouch
mesh_terms: D000258:Adenovirus Infections, Human / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D000260:Adenoviruses, Human / Q000276:immunology*; D000293:Adolescent; D017954:Africa South of the Sahara / Q000453:epidemiology; D000375:Aging; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral