Coinfection with hepatitis C virus increases lymphocyte apoptosis in HIV-infected patients.
To test the role of hepatitis C virus (HCV) in CD4 cell depletion in human immunodeficiency virus (HIV)-coinfected patients, T cell apoptosis was measured by annexin V labeling in 31 HIV-infected and 30 HIV-HCV-coinfected patients who were not receiving antiretroviral therapy. Apoptosis in naive CD4(+) T cells and in naive and memory CD8(+) T cells was significantly higher in HIV-HCV-coinfected than in monoinfected patients.
Núñez
Marina
M
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. mnunez@wfubmc.edu
Soriano
Vincent
V
López
Mariola
M
Ballesteros
Celia
C
Cascajero
Almudena
A
González-Lahoz
Juan
J
Benito
Jose Miguel
JM
D019380:Anti-HIV Agents / Q000494:pharmacology*; D023241:Antiretroviral Therapy, Highly Active; D017209:Apoptosis / Q000187:drug effects*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000473:pathology; D015658:HIV Infections / Q000276:immunology / Q000473:pathology*; D006526:Hepatitis C / Q000276:immunology / Q000473:pathology*; D006801:Humans
D019380:Anti-HIV Agents