Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities.
We report here that phenol derivatives with two and four quaternary ammoniums were synthesized and their abilities to bind and cross-link DNA were investigated. Thermal denaturizing studies indicated that derivatives possess similar DNA binding abilities and gel electrophoresis revealed that more charges (series B) and electronic donation substitute linkers (like -S-) dramatically increase the DNA cross-linking abilities.
Song
Yang
Y
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. of China.
Tian
Tian
T
Wang
Ping
P
He
Hanping
H
Liu
Wulue
W
Zhou
Xiang
X
Cao
Xiaoping
X
Zhang
Xiao-Lian
XL
Zhou
Xin
X
D003432:Cross-Linking Reagents; D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D019800:Phenol; D000644:Quaternary Ammonium Compounds
D003432:Cross-Linking Reagents; D000644:Quaternary Ammonium Compounds; D019800:Phenol; D004247:DNA