title: Sake yeast suppresses acute alcohol-induced liver injury in mice.
abstract: Brewer's and baker's yeasts appear to have components that protect from liver injury. Whether sake yeast, Saccharomyces cerevisiae Kyokai no. 9, also has a hepatoprotective effect has not been examined. Here we show that sake yeast suppresses acute alcoholic liver injury in mice. Male C57BL/6 mice that had been fed a diet containing 1% sake yeast for two weeks received three doses of ethanol (5 g/kg BW). In the mice fed sake yeast, ethanol-induced increases in triglyceride (TG) and glutamate pyruvate transaminase (GPT) were significantly attenuated and hepatic steatosis was improved. In addition, sake yeast-fed mice showed a smaller decrease in hepatic S-adenosylmethionine (SAM) level and a smaller increase in plasma homocysteine (Hcy) level after ethanol treatment than the control mice, suggesting that a disorder of methionine metabolism in the liver caused by ethanol was relieved by sake yeast. These results indicate that sake yeast protects against alcoholic liver injury through maintenance of methionine metabolism in the liver.
authors.affiliation: National Research Institute of Brewing, Japan. izu@nrib.go.jp
authors.forename: Hanae
authors.initials: H
authors.lastname: Izu
authors.forename: Megumi
authors.initials: M
authors.lastname: Shobayashi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Manabe
authors.forename: Kuniyasu
authors.initials: K
authors.lastname: Goto
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Iefuji
mesh_terms: D000208:Acute Disease; D000818:Animals; D001691:Biological Therapy / Q000379:methods*; D000431:Ethanol / Q000009:adverse effects*; D005235:Fatty Liver, Alcoholic / Q000517:prevention & control / Q000628:therapy*; D008297:Male; D008715:Methionine / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D020011:Protective Agents / Q000627:therapeutic use; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D014280:Triglycerides / Q000032:analysis
chemical_list: D020011:Protective Agents; D014280:Triglycerides; D000431:Ethanol; D008715:Methionine