Multiple system atrophy and autonomic failure.
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that affects adults. It is characterised by autonomic failure affecting many systems; cardiovascular, urinary, sexual, gastrointestinal and sudomotor, amongst others. In addition there are motor deficits, resulting in both parkinsonian and/or cerebellar features. This review will outline the clinical features, investigations and management of MSA, with a particular emphasis on autonomic failure.
Mathias
C J
CJ
Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St. Mary's Hospital, UK. c.mathias@imperial.ac.uk
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006801:Humans; D019578:Multiple System Atrophy / Q000503:physiopathology* / Q000628:therapy; D012791:Shy-Drager Syndrome / Q000503:physiopathology*