title: Di-(R,R)-1-[10-(1-hydroxy-2,2,2-trifluoroethyl)-9-anthryl]-2,2,2-trifluoroethyl muconate: a highly chiral cavity for enantiodiscrimination by NMR.
abstract: A new chiral molecular tweezer, di-(R,R)-1-[10-(1-hydroxy-2,2,2-trifluoroethyl)-9-anthryl]-2,2,2-trifluoroethyl muconate 2, was synthesized in enantiopure form, and its geometry was studied using NMR and molecular mechanics. The effectiveness of 2 as a chiral solvating agent for determining the enantiomeric composition of chiral compounds using NMR was demonstrated, improving the results obtained with other methods. The stoichiometry and the association constant of the resulting diastereomeric complexes were studied, and their geometry was analyzed by NOE and 1H NMR.
authors.affiliation: Departament de Química, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
authors.forename: Martina
authors.initials: M
authors.lastname: Palomino-Schätzlein
authors.forename: Albert
authors.initials: A
authors.lastname: Virgili
authors.forename: Sergio
authors.initials: S
authors.lastname: Gil
authors.forename: Carlos
authors.initials: C
authors.lastname: Jaime