title: Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage.
abstract: Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n=85). Comparing the presence of SS with SL+LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (chi2=9.054, df=1, p=0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.
authors.affiliation: The National and the Stockholm County Centre for Suicide Research and Prevention of Mental Ill-Health, Dep of the Public Health Sciences, Karolinska Institute, Stockholm, Sweden. danuta.wasserman@ki.se
authors.forename: Danuta
authors.initials: D
authors.lastname: Wasserman
authors.forename: Thomas
authors.initials: T
authors.lastname: Geijer
authors.forename: Marcus
authors.initials: M
authors.lastname: Sokolowski
authors.forename: Amos
authors.initials: A
authors.lastname: Frisch
authors.forename: Elena
authors.initials: E
authors.lastname: Michaelovsky
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.forename: Vsevolod
authors.initials: V
authors.lastname: Rozanov
authors.forename: Jerzy
authors.initials: J
authors.lastname: Wasserman
mesh_terms: D000328:Adult; D000483:Alleles; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013406:Suicide, Attempted / Q000523:psychology*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA