title: Isolation of Exophiala dermatitidis from endotracheal aspirate of a cancer patient.
abstract: Exophiala (Wangiella) dermatitidis is a melanised (darkly pigmented) yeast-like organism that has been reported from the environment and wild animals. The organism is a frequent coloniser of lungs of patients with cystic fibrosis and causes occasional disseminated phaeohyphomycosis and fungaemia. Exophiala dermatitidis is distributed worldwide, but cerebral cases are restricted to East Asia. We report a case of 54-year-old Qatari female patient with a known history of cancer, suffering from pulmonary disorder. Culture of endotracheal aspirate revealed the growth of E. dermatitidis concomitant with Candida krusei. The final diagnosis of E. dermatitidis and attribution to genotype B was achieved by sequencing the rDNA internal transcribed spacer (ITS) region. The present case concerns a pulmonary colonisation by E. dermatitidis, similar to that commonly seen in cystic fibrosis patients. For the detection of E. dermatitidis in clinical specimens culturing techniques are required. The patient finally expired with persistent cancer and C. krusei fungaemia. Review of literature and listing of E. dermatitidis cases published after 1992 show a sharp increase in clinical cases during the 1990s.
authors.affiliation: Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar. stajaldeen@hmc.org.qa
authors.forename: S J
authors.initials: SJ
authors.lastname: Taj-Aldeen
authors.forename: S
authors.initials: S
authors.lastname: El Shafie
authors.forename: H
authors.initials: H
authors.lastname: Alsoub
authors.forename: Y
authors.initials: Y
authors.lastname: Eldeeb
authors.forename: G S
authors.initials: GS
authors.lastname: de Hoog
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology*; D003110:Colonic Neoplasms / Q000556:secondary; D005093:Exophiala / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008172:Lung Diseases, Fungal / Q000382:microbiology*; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000556:secondary; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000473:pathology