title: Effect of a viscous fiber-containing nutrition bar on satiety of patients with type 2 diabetes.
abstract: To assess the satiety-promoting effect of a novel viscous fiber-containing nutrition bar, overweight and obese adult subjects with type 2 diabetes (n=99) were randomized into a double blind, crossover study. They were fed a 300kcal lunch consisting of viscous fiber-containing nutrition bars (VF) or commercial nutrition control bars designed for people with diabetes (CH). VF resulted in a 27.1% increase in fullness (p<0.05), a 15.8% decrease in prospective consumption (p<0.001), and a 14.2% decrease in hunger (p<0.001) in the 120-240min post-lunch areas under the curve (AUC) compared to CH, but no differences were observed for nausea or thirst (p>0.05). Similar results were noted for 0-300min AUC values. VF were associated with greater frequencies and intensities of abdominal distention (p<0.001) and flatulence (p<0.001), and greater frequency of stools (p<0.001) compared to CH, but there were no differences in mean or maximum (loosest) stool consistency (p>0.05). Overall, these results suggest that VF could be a useful tool in weight management of type 2 diabetes.
authors.affiliation: Ross Products Division, Abbott Laboratories, Columbus, OH 43215-1724, USA. jomay.chow@abbott.com
authors.forename: Jomay
authors.initials: J
authors.lastname: Chow
authors.forename: Yong S
authors.initials: YS
authors.lastname: Choe
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Noss
authors.forename: Kay J
authors.initials: KJ
authors.lastname: Robinson
authors.forename: Janis E
authors.initials: JE
authors.lastname: Dugle
authors.forename: Sonja H
authors.initials: SH
authors.lastname: Acosta
authors.forename: Keith A
authors.initials: KA
authors.lastname: Garleb
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005685:Galactans / Q000008:administration & dosage*; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D008297:Male; D008351:Mannans / Q000008:administration & dosage*; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy; D053149:Plant Gums / Q000008:administration & dosage*; D019518:Postprandial Period; D012528:Satiety Response / Q000187:drug effects*; D014783:Viscosity
chemical_list: D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; C007894:guar gum