Estrogenic activity of furanocoumarins isolated from Angelica dahurica.
In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 microg/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.
Piao
Xiang Lan
XL
School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
Yoo
Hye Hyun
HH
Kim
Hyun Young
HY
Kang
Tak Lim
TL
Hwang
Gwi Seo
GS
Park
Jeong Hill
JH
D000469:Alkaline Phosphatase / Q000096:biosynthesis; D029969:Angelica / Q000737:chemistry*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004790:Enzyme Induction / Q000187:drug effects; D011564:Furocoumarins / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D048789:Phytoestrogens / Q000302:isolation & purification* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
D011564:Furocoumarins; D048789:Phytoestrogens; D010936:Plant Extracts; D011960:Receptors, Estrogen; D000469:Alkaline Phosphatase