Density dependence and the control of helminth parasites.
1. The transient dynamics and stability of a population are determined by the interplay between species density, its spatial distribution and the positive and negative density-dependent processes regulating population growth. 2. Using the human-helminth parasite system as an example, we propose that the life-stage upon which negative density dependence operates will influence the rate of host reinfection following anthelmintic chemotherapy, and the likely success of control programmes. 3. Simple deterministic models are developed which highlight how a parasite species whose population size is down-regulated by density-dependent establishment will reinfect a host population at a faster rate than a species with density-dependent parasite fecundity. 4. Different forms of density dependence can produce the same equilibrium behaviour but different transient dynamics. Under-representing the nature and magnitude of density-dependent mechanisms, and in particular those operating upon establishing life-stages, may cause the resilience of the parasite population to a control perturbation to be underestimated.
Churcher
Thomas S
TS
Department of Infectious Disease Epidemiology, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, UK.
Filipe
João A N
JA
Basáñez
María-Gloria
MG
D000818:Animals; D006376:Helminths / Q000502:physiology*; D006790:Host-Parasite Interactions; D006801:Humans; D008954:Models, Biological; D011156:Population Density; D012098:Reproduction / Q000502:physiology; D013997:Time Factors