title: Multifrequency vibro-acoustography.
abstract: Elasticity imaging is a burgeoning medical imaging field. Many methods have been proposed that impart a force to tissue and measure the mechanical response. One method, vibro-acoustography, uses the ultrasound radiation force to harmonically vibrate tissue and measure the resulting acoustic emission field with a nearby hydrophone. Another method, vibrometry, uses the ultrasound radiation force accompanied with a measurement of the resulting velocity or displacement of the vibrating tissue or object has also been used for different applications. An extension of the vibro-acoustography method using a multifrequency stress field to vibrate an object is described. The objective of this paper is to present the image formation theory for multifrequency vibro-acoustography. We show that the number of low-frequency components created by this multifrequency method scales with the square of the number of ultrasound sources used. We provide experimental validation of the point-spread function of the multifrequency stress field and show examples of both vibrometry and vibro-acoustography imaging applications. This method holds the potential for a large gain of information with no increase in scanning time compared to conventional vibro-acoustography systems.
authors.affiliation: Ultrasound Research Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. urban.matthew@mayo.edu
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Urban
authors.forename: Glauber T
authors.initials: GT
authors.lastname: Silva
authors.forename: Mostafa
authors.initials: M
authors.lastname: Fatemi
authors.forename: James F
authors.initials: JF
authors.lastname: Greenleaf
mesh_terms: D000162:Acoustics; D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods; D033401:Microscopy, Acoustic / Q000379:methods*; D008954:Models, Biological; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000295:instrumentation / Q000379:methods*; D014732:Vibration