Collagen-poly glycolic acid hybrid matrix with basic fibroblast growth factor accelerated angiogenesis and granulation tissue formation in diabetic mice.
Because poor skin wound healing associated with diabetes is thought to be partly a result from impaired angiogenesis, treatments that improve angiogenesis could have important clinical applications. We herein report the effects of novel developed material, collagen-poly glycolic acid fiber hybrid matrix, being used together with basic fibroblast growth factor to promote wound healing of full-thickness skin defects on the back of type 2 diabetic Lepr(db) mice. Our data indicates that this therapeutic approach markedly promotes angiogenesis and granulation tissue formation in comparison with other conditions 14 days after wounding.
Nagato
Hajime
H
Department of Dermatology and Plastic Surgery, Akita University School of Medicine, Hondo 1-1-1, Akita-shi, Akita 010-8543, Japan. naganaga@doc.med.akita-u.ac.jp
Umebayashi
Yoshihiro
Y
Wako
Masahiko
M
Tabata
Yasuhiko
Y
Manabe
Motomu
M
D000818:Animals; D003094:Collagen; D003924:Diabetes Mellitus, Type 2; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D006097:Granulation Tissue / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011100:Polyglycolic Acid; D015503:Surgical Sponges; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000503:physiopathology* / Q000628:therapy*
D016222:Fibroblast Growth Factor 2; D011100:Polyglycolic Acid; D003094:Collagen