Latent reservoirs for HIV-1.
Combination therapy for HIV-1 infection can reduce viremia to undetectable levels, suggesting that prolonged treatment might eradicate the infection. However, one potential mechanism for viral persistence involves the establishment of a state of latent infection. Recent studies have directly confirmed that HIV-1 establishes a state of latent infection in resting memory CD4(+) T cells in vivo. This reservoir is likely to frustrate current efforts to eradicate the infection with combination therapy.
Blankson
J
J
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Persaud
D
D
Siliciano
R F
RF