Matrix metalloproteinase-2 and -9 expression in sinonasal inverted papilloma.
BACKGROUND
Inverted papilloma (IP) is a proliferative lesion of the epithelium lining the sinonasal tract, characterized by marked propensity for recurrence and association with carcinoma. To determine a putative role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in the establishment of IP, their expression was studied in IP.


METHODS
Archived surgical specimens from 15 IPs were studied using immunohistochemistry and compared to 12 nasal polyps (NP), a model of chronic respiratory mucosal inflammation, and to 6 control nasal mucosa (CM) samples obtained from snorers during turbinectomy. Within IP, MMP-2 and -9 expression was compared between tumoral areas with hyperplastic epithelium and non tumoral areas with nonhyperplastic epithelium.


RESULTS
In IP, MMP-2 and MMP-9 epithelial expression was not different compared to CM and NP. MMP-9 expression in submucosal inflammatory cells was not different between IP and CM or NP. However, within IP, a significantly increased number of MMP-9 positive inflammatory cells in the lamina propria adjacent to the hyperplastic epithelium was observed compared to the lamina propria adjacent to nonhyperplastic epithelium.


CONCLUSIONS
Our findings suggest that MMP 9 expressing inflammatory cells may be involved in the pathophysiology of IP.
Papon
J F
JF
Service d'ORL et de Chirurgie Cervico-Faciale, Hopital Henri Mondor, Assistance Publique-Hopitaux de Paris, Créteil, France. jean-francois.papon@hmn.aphp.fr
Lechapt-Zalcman
E
E
Abina
M
M
Abd-al-Sama
I
I
Peynègre
R
R
Escudier
E
E
Coste
A
A
D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D009298:Nasal Polyps / Q000378:metabolism / Q000473:pathology; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9