Regulatory T-cells: immunomodulators in health and disease.
Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.
Scalzo
Karen
K
Vaccine and Infectious Disease Laboratory, Burnet Institute at Austin, Studley Rd, Heidelberg Victoria 3084, Australia.
Plebanski
Magdalena
M
Apostolopoulos
Vasso
V
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy*; D006262:Health; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*