title: [New molecular markers within the chronic myeloproliferative disorders. I: the PRV-1 gene].
abstract: PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having "masked" PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.
authors.affiliation: Odense Universitetshospital, Patologisk Institut og Haematologisk Afdeling X. thomas.stauffer.larsen@ouh.fyns-amt.dk
authors.forename: Thomas Stauffer
authors.initials: TS
authors.lastname: Larsen
authors.forename: Niels
authors.initials: N
authors.lastname: Pallisgaard
authors.forename: Jacob Haaber
authors.initials: JH
authors.lastname: Christensen
authors.forename: Paul
authors.initials: P
authors.lastname: Gram-Hansen
authors.forename: Gitte B
authors.initials: GB
authors.lastname: Kerndrup
authors.forename: Michael Boe
authors.initials: MB
authors.lastname: Møller
authors.forename: Hans Carl
authors.initials: HC
authors.lastname: Hasselbalch
mesh_terms: D015415:Biomarkers / Q000097:blood*; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D058851:GPI-Linked Proteins; D015870:Gene Expression; D006801:Humans; D007519:Isoantigens / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics*; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D010677:Philadelphia Chromosome; D011087:Polycythemia Vera / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D055728:Primary Myelofibrosis / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000235:genetics*; D013922:Thrombocytosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics
chemical_list: D015415:Biomarkers; C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D007519:Isoantigens; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface