title: Image-guided core-needle biopsy of peripheral lymph nodes allows the diagnosis of lymphomas.
abstract: It is commonly admitted that the diagnosis of lymphomas can be assessed by the image-guided needle biopsy (IGNB) of deep lymph nodes. However, when peripheral lymph nodes are present, surgical dissection remains the standard strategy. The aim of this study was to evaluate the diagnostic yield of IGNB of peripheral lymph nodes in patients with suspected lymphomas. The records of 180 multisampling IGNBs of peripheral lymph nodes in 180 patients were reviewed. One hundred and twenty-three IGNBs were observed at first diagnosis and 57 at progression using large-cutting core-biopsy needles ranging between 18 G and 14 G in size. Immunohistochemistry studies were performed in all cases and at least one biopsy was systematically frozen. A diagnosis of lymphoma with sufficient information such that a therapeutic decision could be made was obtained in 146 of the 152 patients with lymphoproliferative disorders (96%). IGNB was equally effective in making the correct diagnosis of lymphoma at the time of original diagnosis than at relapse. The results did not depend on the biopsy site, lymph nodes size, or needle type. We recommend that IGNB may be performed as an initial procedure for the diagnosis of lymphomas either in the presence of peripheral or deep lymph nodes, as it avoids surgery.
authors.affiliation: Service de Radiologie, Hôpital Saint-Louis AP-HP, 1 Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France. eric.de-kerviler@sls.ap-hop-paris.fr
authors.forename: Eric
authors.initials: E
authors.lastname: de Kerviler
authors.forename: Cédric
authors.initials: C
authors.lastname: de Bazelaire
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mounier
authors.forename: Olivier
authors.initials: O
authors.lastname: Mathieu
authors.forename: Benoît
authors.initials: B
authors.lastname: Brethon
authors.forename: Josette
authors.initials: J
authors.lastname: Brière
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Marolleau
authors.forename: Pauline
authors.initials: P
authors.lastname: Brice
authors.forename: Christian
authors.initials: C
authors.lastname: Gisselbrecht
authors.forename: Jacques
authors.initials: J
authors.lastname: Frija
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods*; D002648:Child; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography