title: MRSP1, encoding a novel Trichoderma secreted protein, is negatively regulated by MAPK.
abstract: A novel gene, MRSP1 (MAP kinase repressed secreted protein 1) is strongly overexpressed in the tmkA MAPK mutant of the biocontrol fungus Trichoderma virens. Transcriptional regulation of MRSP1 is determined by presence or absence of TmkA, rather than by light or sporulation, making it a molecular marker for the unusual, negative, regulation by TmkA. The predicted protein is 15.9 kDa, has a secretory signal, and the four-cysteine pattern, C-X29-CP(G)C-X31-C, may define a new cysteine-rich motif. This is a novel protein with functions not known from any other organism. Conservation in ascomycete, basidiomycete, and Dictyostelium homologs, as well as tight MAPK regulation, might indicate important cellular functions.
authors.affiliation: Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai 400085, India. prasunmukherjee1@gmail.com
authors.forename: Prasun K
authors.initials: PK
authors.lastname: Mukherjee
authors.forename: Ruthi
authors.initials: R
authors.lastname: Hadar
authors.forename: Ella
authors.initials: E
authors.lastname: Pardovitz-Kedmi
authors.forename: Naomi
authors.initials: N
authors.lastname: Trushina
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Horwitz
mesh_terms: D002478:Cells, Cultured; D015536:Down-Regulation; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D014242:Trichoderma / Q000502:physiology*
chemical_list: D005656:Fungal Proteins; D020928:Mitogen-Activated Protein Kinases