[Genetic polymorphism of glutathione-S-transferases and inhibition of DNA repair].
A complex investigation of different cell defence systems, such as: DNA repair, antioxidant system (SOD), xenobiotic detoxification system (glutathione-S-transferases M1 and T1), radioadaptive response (RAR) in lymphocytes of patients with hereditary disease of connective tissue (Elers-Danlose syndrome) was carried out. The frequency of genotype GSTM1 (0/0) in children with Elers-Danlose syndrome (23%) is lower as compared to the control group (44%). The lymphocytes of children with Elers-Danlose syndrome were characterized by reduced ability to repair gamma-induced damage of DNA. At given size of the samples of examined children no correlative relationships between GST-status of organism and the condition of other cell defence systems were revealed. The data obtained demonstrate the individual peculiarities of the defence systems in repair-deficient cells of the examined children.
Kuz'mina
N S
NS
Vasil'eva
I M
IM
Sinelshchikova
T A
TA
Semiachkina
A N
AN
Kuznetsova
G I
GI
Shevchenko
V A
VA
Zasukhina
G D
GD
D002648:Child; D004247:DNA / Q000032:analysis; D004260:DNA Repair / Q000235:genetics*; D004535:Ehlers-Danlos Syndrome / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D008297:Male; D011110:Polymorphism, Genetic
D004247:DNA; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1