title: Biomechanical properties of bone cement with addition of cefuroxime antibiotic.
abstract: Antibiotic-loaded bone cement has been used as prophylaxis against infection in total joint replacement surgery. Its effect on the mechanical strength of cement is a major concern as high dose of antibiotic was associated with a significant reduction in mechanical strength of bone cement. However, the cut-off antibiotic that weakens the mechanical strength of cement remains to be determined. This study was undertaken to observe the changes in the mechanical properties of bone cement with gradual increments of Cefuroxime antibiotic. Cefuroxime at different doses: 0, 1.5, 3.0 and 4.5gm were added to a packet of 40gm bone cement (Simplex P) and study samples were prepared by using third generation cementing technique. Mechanical impact, flexural and tensile strength were tested on each sample. Significant impact and tensile strength reduction were observed after addition of 4.5 gm of Cefuroxime. However, flexural strength was significantly reduced at a lower dose of 3.0 gm. The maximum dose of Cefuroxime to be safely added to 40mg Surgical Simplex P is 1.5gm when third generation cementing technique is used. Further study is needed to determine whether it is an effective dose as regards to microbiological parameters.
authors.affiliation: Department of Orthopaedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.
authors.forename: D
authors.initials: D
authors.lastname: Mohd Fuad
authors.forename: O
authors.initials: O
authors.lastname: Masbah
authors.forename: Y
authors.initials: Y
authors.lastname: Shahril
authors.forename: S
authors.initials: S
authors.lastname: Jamari
authors.forename: M Y
authors.initials: MY
authors.lastname: Norhamdan
authors.forename: S H
authors.initials: SH
authors.lastname: Sahrim
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019072:Antibiotic Prophylaxis / Q000295:instrumentation*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D001843:Bone Cements / Q000032:analysis*; D002444:Cefuroxime / Q000008:administration & dosage / Q000494:pharmacology*; D019245:Compressive Strength; D004337:Drug Carriers / Q000032:analysis*; D006801:Humans; D008422:Materials Testing; D013314:Stress, Mechanical; D013530:Surgical Wound Infection / Q000517:prevention & control; D013718:Tensile Strength
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D004337:Drug Carriers; D002444:Cefuroxime