title: JAK2V617F mutations as cooperative genetic lesions in t(8;21)-positive acute myeloid leukemia.
abstract: Significant progress has been made in identifying genetic lesions that are causally implicated in the pathogenesis of acute myeloid leukemia (AML). These insights improve our understanding of the genetic basis of the disease, a prerequisite for the development of novel therapeutic approaches.
authors.forename: Konstanze
authors.initials: K
authors.lastname: Döhner
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Andrea
authors.initials: A
authors.lastname: Corbacioglu
authors.forename: Claudia
authors.initials: C
authors.lastname: Scholl
authors.forename: Richard F
authors.initials: RF
authors.lastname: Schlenk
authors.forename: Hartmut
authors.initials: H
authors.lastname: Döhner
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009154:Mutation
chemical_list: C507924:JAK2 protein, human; D053614:Janus Kinase 2