title: The significance of peroxisomes in methanol metabolism in methylotrophic yeast.
abstract: The capacity to use methanol as sole source of carbon and energy is restricted to relatively few yeast species. This may be related to the low efficiency of methanol metabolism in yeast, relative to that of prokaryotes. This contribution describes the details of methanol metabolism in yeast and focuses on the significance of compartmentalization of this metabolic pathway in peroxisomes.
authors.affiliation: Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, P.O. Box 14, NL-9750 AA Haren, The Netherlands.
authors.forename: Ida J
authors.initials: IJ
authors.lastname: van der Klei
authors.forename: Hiroya
authors.initials: H
authors.lastname: Yurimoto
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Sakai
authors.forename: Marten
authors.initials: M
authors.lastname: Veenhuis
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism; D019880:Aldehyde-Ketone Transferases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D005557:Formaldehyde / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005979:Glutathione Peroxidase / Q000378:metabolism; D000432:Methanol / Q000378:metabolism*; D020675:Peroxisomes / Q000201:enzymology*; D010843:Pichia / Q000235:genetics / Q000378:metabolism*; D013869:Thiolester Hydrolases / Q000378:metabolism
chemical_list: D005557:Formaldehyde; D000429:Alcohol Oxidoreductases; C019643:alcohol oxidase; D002374:Catalase; D005979:Glutathione Peroxidase; D019880:Aldehyde-Ketone Transferases; C031222:formaldehyde transketolase; D013869:Thiolester Hydrolases; C020149:s-formylglutathione hydrolase; D000432:Methanol