title: Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans.
abstract: OBJECTIVE
  To explore the potential role of the endogenous peptide YY (PYY) in the long-term regulation of body weight and energy homeostasis.
  
  
  METHODS
  Fasting and postprandial plasma PYY concentrations were measured after an overnight fast and 30 to 180 minutes after a standardized meal in 29 (21 men/8 women) non-diabetic subjects, 16 of whom had a follow-up visit 10.8 +/- 1.4 months later. Ratings of hunger and satiety were collected using visual analog scales. Resting metabolic rate (RMR) (15-hour RMR) and respiratory quotient (RQ) were assessed using a respiratory chamber.
  
  
  RESULTS
  Fasting PYY concentrations were negatively correlated with various markers of adiposity and negatively associated with 15-hour RMR (r = -0.46, p = 0.01). Postprandial changes in PYY (area under the curve) were positively associated with postprandial changes in ratings of satiety (r = 0.47, p = 0.01). The maximal PYY concentrations achieved after the meal (peak PYY) were negatively associated with 24-hour RQ (r = -0.41, p = 0.03). Prospectively, the peak PYY concentrations were negatively associated with changes in body weight (r = -0.58, p = 0.01).
  
  
  CONCLUSIONS
  Our data indicate that the endogenous PYY may be involved in the long-term regulation of body weight. It seems that this long-term effect was not exclusively driven by the modulation of food intake but also by the control of energy expenditure and lipid metabolism.
authors.affiliation: Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. yanguo@phx.niddk.nih.gov
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Lijun
authors.initials: L
authors.lastname: Ma
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Enriori
authors.forename: Juraj
authors.initials: J
authors.lastname: Koska
authors.forename: Paul W
authors.initials: PW
authors.lastname: Franks
authors.forename: Thomas
authors.initials: T
authors.lastname: Brookshire
authors.forename: Michael A
authors.initials: MA
authors.lastname: Cowley
authors.forename: Arline D
authors.initials: AD
authors.lastname: Salbe
authors.forename: Angelo
authors.initials: A
authors.lastname: Delparigi
authors.forename: P Antonio
authors.initials: PA
authors.lastname: Tataranni
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001481:Basal Metabolism / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005215:Fasting / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006815:Hunger / Q000502:physiology; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D019894:Peptide YY / Q000502:physiology*; D019518:Postprandial Period; D012528:Satiety Response / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019894:Peptide YY