A distinct group of non-cholinergic neurons along the mid-line of the septum and within the rat medial septal nucleus.
The septum is a critical and integral component of the limbic brain that serves as a link between diverse brain structures while being necessary for human cognition and emotionality. A major anatomical component of the septum is designated as the medial septum/diagonal band of Broca complex (MS/DB). A primary focus of much research has been to investigate cholinergic neurons within the MS/DB, as these are the rodent brain's main source of acetylcholine to the cortex and hippocampus. On the other hand, we have chosen to investigate a specific group of neurons that lie on the midline of the MS/DB in an area distinguished anatomically as the medial septal nucleus (MSN). Based on somatic morphology and electrophysiological characteristics we conclude that these neurons, characterized into three different types, are non-cholinergic.
Tsurusaki
Massashi
M
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Gallagher
Joel P
JP
D000109:Acetylcholine / Q000378:metabolism*; D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000145:classification* / Q000502:physiology* / Q000528:radiation effects; D018408:Patch-Clamp Techniques / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D012686:Septal Nuclei / Q000166:cytology*
D000109:Acetylcholine