The sea urchin kinome: a first look.
This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is closer to the Drosophila kinome (239) than the human kinome (518) with respect to total kinase number. However, the diversity of sea urchin kinases is surprisingly similar to humans, since the urchin kinome is missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the sea urchin kinome combines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the sea urchin kinases are involved with signal transduction, and approximately 88% of the signaling kinases are expressed in the developing embryo. These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism.
Bradham
Cynthia A
CA
DCMB Group, Duke University, Box 91000, Durham, NC 27708, USA. cabrad@duke.edu
Foltz
Kathy R
KR
Beane
Wendy S
WS
Arnone
Maria I
MI
Rizzo
Francesca
F
Coffman
James A
JA
Mushegian
Arcady
A
Goel
Manisha
M
Morales
Julia
J
Geneviere
Anne-Marie
AM
Lapraz
François
F
Robertson
Anthony J
AJ
Kelkar
Hemant
H
Loza-Coll
Mariano
M
Townley
Ian K
IK
Raisch
Michael
M
Roux
Michelle M
MM
Lepage
Thierry
T
Gache
Christian
C
McClay
David R
DR
Manning
Gerard
G
D000818:Animals; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D010766:Phosphorylation; D010802:Phylogeny; D011494:Protein Kinases / Q000145:classification / Q000235:genetics*; D012617:Sea Urchins / Q000145:classification / Q000196:embryology / Q000235:genetics* / Q000254:growth & development*; D015398:Signal Transduction
D011494:Protein Kinases