Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice.
In a mouse model, ertapenem inhibited the anaerobic intestinal microflora and promoted overgrowth of enterococci, whereas imipenem-cilastatin had no effect on the indigenous microflora. Ertapenem, but not imipenem-cilastatin, promoted modest overgrowth of vancomycin-resistant enterococci when exposure occurred during treatment. Neither agent promoted colonization with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae.
Stiefel
Usha
U
Infectious Diseases Section (111 W), Louis Stokes Cleveland Department of VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.
Pultz
Nicole J
NJ
Donskey
Curtis J
CJ
D000818:Animals; D015780:Carbapenems / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D015377:Cilastatin / Q000494:pharmacology; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations; D016983:Enterococcus / Q000187:drug effects* / Q000254:growth & development; D000077727:Ertapenem; D005260:Female; D015378:Imipenem / Q000494:pharmacology; D007422:Intestines / Q000187:drug effects* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D010878:Piperacillin / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors; D020713:Vancomycin Resistance; D047090:beta-Lactams / Q000494:pharmacology
D015780:Carbapenems; D004338:Drug Combinations; D047090:beta-Lactams; D015377:Cilastatin; D012965:Sodium Chloride; D015378:Imipenem; D002443:Ceftriaxone; D000077728:Cilastatin, Imipenem Drug Combination; D000077727:Ertapenem; D010878:Piperacillin