title: Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats.
abstract: We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P<0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by Rhus verniciflua (50 mg/kg) supplementation in diabetic rats.
authors.affiliation: Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University, South Korea.
authors.forename: Chang Hwa
authors.initials: CH
authors.lastname: Jung
authors.forename: Song
authors.initials: S
authors.lastname: Zhou
authors.forename: Guo Xun
authors.initials: GX
authors.lastname: Ding
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Myung Hee
authors.initials: MH
authors.lastname: Hong
authors.forename: Yong-Cheol
authors.initials: YC
authors.lastname: Shin
authors.forename: Gyung Jun
authors.initials: GJ
authors.lastname: Kim
authors.forename: Seong-Gyu
authors.initials: SG
authors.lastname: Ko
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D029001:Herbal Medicine; D006943:Hyperglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D013311:Streptozocin