Scleritis complicating zoledronic acid infusion.
We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner. Subsequent use of pamidronate was associated with milder inflammation in the same eye that eventually resolved with continued monthly infusions, indicating the possibility of immunologic tolerance. Physicians prescribing these drugs should be aware of this side effect, which, if not recognized and treated appropriately, is potentially devastating. We review the published data as well as the current treatment recommendations.
Benderson
David
D
Department of Ophthalmology, University of Maryland, Baltimore, MD 21201, USA.
Karakunnel
Joyson
J
Kathuria
Sajeev
S
Badros
Ashraf
A
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004164:Diphosphonates / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D000077268:Pamidronate; D011859:Radiography; D015423:Scleritis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000077211:Zoledronic Acid
D000893:Anti-Inflammatory Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D000077268:Pamidronate