Direct synthesis of tricyclic 5H-pyrido[3,2,1-ij]quinolin-3-one by domino palladium catalyzed reaction.
Unexpectedly, the palladium catalyzed coupling reaction of acrolein with 8-bromoquinoline gave 5H-pyrido[3,2,1-ij]quinolin-3-one in a single step.
Noël
Sébastien
S
Institut de Recherches sur la Catalyse, UPR 5401, CNRS, 2 avenue Albert Einstein, 69626 Villeurbanne, France.
Pinel
Catherine
C
Djakovitch
Laurent
L
D000171:Acrolein / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature
C522368:5H-pyrido(3,2,1-ij)quinolin-3-one; D011725:Pyridines; D015363:Quinolones; D010165:Palladium; D000171:Acrolein