Predictors of death within six months in patients with advanced AIDS.
OBJECTIVE
This study sought to identify potential predictive variables of death within 6 months in patients with advanced AIDS.


METHODS
Investigators enrolled a consecutive series of patients with advanced AIDS admitted to a skilled nursing facility in New York City over a 1-year period. Demographic, clinical, laboratory, and outcome data were abstracted from medical records using a standardized data collection instrument.


RESULTS
Of the 152 patients enrolled during the study period, 61 patients (40%) died within 6 months from date of admission. Serum albumin, percent deviation from ideal body weight, and number of comorbidities at the time of admission proved to be the best combination of predictors of death within 6 months.


CONCLUSIONS
The decrease in AIDS mortality over the past decade, along with an increase in prevalence due to longer survival, has been attributed primarily to the successful use of highly active antiretroviral therapy (HAART). HAART regimens, however, can also produce both short-term adverse effects and long-term complications. The prognostic model developed by this study may be useful in guiding treatment decisions in patients with advanced AIDS for whom a more palliative care plan may be sought.
Brechtl
John R
JR
Terence Cardinal Cooke Health Care Center, Medical Administration, 1249 Fifth Avenue, 9th Floor, New York, NY 10029, USA. jbrechtl@chcsnet.org
Patrick
Patricia A
PA
Visintainer
Paul
P
Brand
Donald A
DA
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000097:blood*; D001835:Body Weight; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009519:New York City; D010166:Palliative Care / Q000706:statistics & numerical data*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*; D012866:Skilled Nursing Facilities / Q000706:statistics & numerical data; D016019:Survival Analysis
D015415:Biomarkers; D012709:Serum Albumin