[The role of leptin in the development of hypertension].
Leptin, the product the ob gene, is secreted by adipocytes to regulate energy homeostasis. This hormone may have an important influence on blood pressure, leading to hypertension. Leptin, acting in the hypothalamic melanocortin system, can activate or inactivate neuropeptides and produce hypertension, mainly by renal, adrenal, and muscular sympathoactivation. The role of leptin in regulating cardiovascular function in obesity is presented based on contemporary literature. Both intracellular signaling pathways activated by leptin and the role of leptin receptors are also discussed. The roles of endogens, neuropeptides in food intake, and energy expenditure are also presented.
Dubiński
Andrzej
A
Powiatowe Centrum Zdrowia w Kamiennej Górze, Sp. z o.o. NZOZ, Szpital Powiatowy. pcz@pcz.org.pl
Zdrojewicz
Zygmunt
Z
D000273:Adipose Tissue / Q000378:metabolism* / Q000502:physiology; D004734:Energy Metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007031:Hypothalamus / Q000502:physiology; D020738:Leptin / Q000378:metabolism* / Q000502:physiology; D009765:Obesity / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D054411:Receptors, Leptin; D015398:Signal Transduction; D013564:Sympathetic Nervous System / Q000378:metabolism
C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin