Effect of donepezil on motor and cognitive function in Huntington disease.
Striatal cholinergic dysfunction may be important in Huntington disease (HD). We studied whether donepezil improves chorea, cognition, and quality of life (QoL) in HD. Thirty patients were randomly assigned to treatment with donepezil or placebo. At the doses studied, donepezil did not improve chorea, cognition, or QoL. Adverse events were similar between both groups. Based on this small sample study, donepezil was not an effective treatment for HD.
Cubo
E
E
Movement Disorders Unit, Neurology Department, Rush University Medical Center, Chicago, IL, USA. estercub@wanadoo.es
Shannon
K M
KM
Tracy
D
D
Jaglin
J A
JA
Bernard
B A
BA
Wuu
J
J
Leurgans
S E
SE
D002819:Chorea / Q000209:etiology / Q000517:prevention & control*; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D000077265:Donepezil; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000188:drug therapy*; D007189:Indans / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018697:Nootropic Agents / Q000627:therapeutic use; D017063:Outcome Assessment, Health Care; D010880:Piperidines / Q000627:therapeutic use*; D015990:Placebo Effect; D011788:Quality of Life; D020127:Recovery of Function / Q000187:drug effects*; D016896:Treatment Outcome
D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil