title: Oxytocin-associated rupture of an unscarred uterus in a primigravida.
abstract: BACKGROUND
  Intrapartum rupture of the unscarred uterus is an uncommon event, usually associated with such risk factors as grand multiparity, malpresentation, history of gestational trophoblastic disease, or instrumented delivery. Rupture during first pregnancy is extremely rare.
  
  
  METHODS
  A 30-year-old primigravid woman was admitted for labor augmentation with oxytocin at 40.5 weeks of gestation. The oxytocin infusion rate was increased during the first and second stages of labor despite contractions occurring at a rate of 4-5 per 10 minutes. The uterus ruptured during second stage. Despite emergency cesarean delivery, the baby had evidence of severe asphyxia.
  
  
  CONCLUSIONS
  This case of uterine rupture in a primigravida with no prior uterine surgery and a structurally normal uterus underscores the importance of careful contraction monitoring and judicious control of oxytocin infusion rates.
authors.affiliation: Maternal Fetal Medicine, San Diego Perinatal Center and Sharp Mary Birch Hospital for Women, San Diego, CA 92123, USA. Vcatanza@aol.com
authors.forename: Val
authors.initials: V
authors.lastname: Catanzarite
authors.forename: Larry
authors.initials: L
authors.lastname: Cousins
authors.forename: David
authors.initials: D
authors.lastname: Dowling
authors.forename: Sean
authors.initials: S
authors.lastname: Daneshmand
mesh_terms: D000328:Adult; D001238:Asphyxia Neonatorum / Q000209:etiology; D002547:Cerebral Palsy / Q000209:etiology; D002585:Cesarean Section; D004638:Emergency Treatment; D005260:Female; D020073:Gravidity; D006801:Humans; D007231:Infant, Newborn; D007748:Labor Stage, Second; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D014590:Uterine Contraction; D014597:Uterine Rupture / Q000139:chemically induced*
chemical_list: D010121:Oxytocin