A human lymph node in vitro--challenges and progress.
Extracorporeal human lymphatic organs are expected to be excellent tools in the study of human molecular and cellular bases of the immunologic balance and tissue harmony. A rational approach and process to design a device and a procedure to recreate the human lymph node environment in vitro is described with emphasis on T-cell activation. Based on this approach, a bioreactor and a process supporting self-assembly of human lymphatic tissues due to proper emulation of human architecture and homeostasis could be developed.
Giese
Christoph
C
ProBioGen AG, Berlin, Germany. christoph.giese@probiogen.de
Demmler
Christian D
CD
Ammer
Richard
R
Hartmann
Stefan
S
Lubitz
Annika
A
Miller
Lilja
L
Müller
Riccarda
R
Marx
Uwe
U
D019149:Bioreactors; D002454:Cell Differentiation; D005782:Gels; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology*; D009940:Organoids / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*
D005782:Gels