title: Collagen-poly glycolic acid hybrid matrix with basic fibroblast growth factor accelerated angiogenesis and granulation tissue formation in diabetic mice.
abstract: Because poor skin wound healing associated with diabetes is thought to be partly a result from impaired angiogenesis, treatments that improve angiogenesis could have important clinical applications. We herein report the effects of novel developed material, collagen-poly glycolic acid fiber hybrid matrix, being used together with basic fibroblast growth factor to promote wound healing of full-thickness skin defects on the back of type 2 diabetic Lepr(db) mice. Our data indicates that this therapeutic approach markedly promotes angiogenesis and granulation tissue formation in comparison with other conditions 14 days after wounding.
authors.affiliation: Department of Dermatology and Plastic Surgery, Akita University School of Medicine, Hondo 1-1-1, Akita-shi, Akita 010-8543, Japan. naganaga@doc.med.akita-u.ac.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Nagato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Umebayashi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Wako
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
authors.forename: Motomu
authors.initials: M
authors.lastname: Manabe
mesh_terms: D000818:Animals; D003094:Collagen; D003924:Diabetes Mellitus, Type 2; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage*; D006097:Granulation Tissue / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011100:Polyglycolic Acid; D015503:Surgical Sponges; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D016222:Fibroblast Growth Factor 2; D011100:Polyglycolic Acid; D003094:Collagen