title: Role of cytokines in head and neck squamous cell carcinoma.
abstract: Head and neck squamous cell carcinoma is one of the most frequent cancers and standard treatment has only marginally improved the 5-year survival rate of patients with this disease in the last few decades. It is supposed that cytokine alterations in immune, inflammatory and angiogenetic regulatory routes within the head and neck squamous cell carcinoma microenvironment play a critical role in tumor aggressiveness, its response to chemo- and radiation therapies, as well as the development of immune escape mechanisms.
authors.affiliation: University of Schleswig-Holstein Campus Lübeck, Department of Otorhinolaryngology, Ratzeburger Allee 160, 23538 Lübeck, Germany. ralph.pries@hno.uni-luebeck.de
authors.forename: Ralph
authors.initials: R
authors.lastname: Pries
authors.forename: Stefan
authors.initials: S
authors.lastname: Nitsch
authors.forename: Barbara
authors.initials: B
authors.lastname: Wollenberg
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D016207:Cytokines / Q000502:physiology*; D006258:Head and Neck Neoplasms / Q000098:blood supply / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000276:immunology / Q000517:prevention & control
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators