title: Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans.
abstract: The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-beta-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.
authors.affiliation: Department of Infectious Disease Research, Merck Research Laboratories, RY80Y-260, P.O. Box 2000, Rahway, NJ 07065-0900, USA. joel_bowman@merck.com
authors.forename: J C
authors.initials: JC
authors.lastname: Bowman
authors.forename: G K
authors.initials: GK
authors.lastname: Abruzzo
authors.forename: A M
authors.initials: AM
authors.lastname: Flattery
authors.forename: C J
authors.initials: CJ
authors.lastname: Gill
authors.forename: E J
authors.initials: EJ
authors.lastname: Hickey
authors.forename: M J
authors.initials: MJ
authors.lastname: Hsu
authors.forename: J Nielsen
authors.initials: JN
authors.lastname: Kahn
authors.forename: P A
authors.initials: PA
authors.lastname: Liberator
authors.forename: A S
authors.initials: AS
authors.lastname: Misura
authors.forename: B A
authors.initials: BA
authors.lastname: Pelak
authors.forename: T C
authors.initials: TC
authors.lastname: Wang
authors.forename: C M
authors.initials: CM
authors.lastname: Douglas
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001230:Aspergillus / Q000187:drug effects*; D001231:Aspergillus flavus / Q000187:drug effects*; D001233:Aspergillus nidulans / Q000187:drug effects*; D000077336:Caspofungin; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D054714:Echinocandins; D005260:Female; D055666:Lipopeptides; D051379:Mice; D008811:Mice, Inbred DBA; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000077336:Caspofungin