title: Studies on the constituents of the leaves of Baccharis dracunculifolia (Asteraceae) and their cytotoxic activity.
abstract: A new sesquiterpene, named baccharisketone (1), and a new monoterpene, p-methoxythymol acetate (2), were isolated from the leaves of Baccharis dracunculifolia along with seventeen known compounds (3-19). The structures of the new compounds were determined by spectroscopic means. The growth inhibitory activity of the isolated compounds against leukemia cells (L 1210) was tested and three terpene phenols (4, 6, 17) and five sesquiterpene alcohols (8, 10, 11, 13, 16) were found to exhibit strong cytotoxic activity.
authors.affiliation: College of Pharmacy, Nihon University, Funabashi, Chiba, Japan. mamoru.fukuda@mb.kyorin-pharm.co.jp
authors.forename: Mamoru
authors.initials: M
authors.lastname: Fukuda
authors.forename: Emika
authors.initials: E
authors.lastname: Ohkoshi
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Makino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fujimoto
mesh_terms: D031175:Baccharis / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D039821:Monoterpenes; D012717:Sesquiterpenes; C516243:baccharisketone; C516244:methoxythymol acetate