Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study.
We investigated whether regular aerobic exercise could affect plasma total homocysteine (tHcy), and whether there were sex-related or racial differences in tHcy changes. Data were available for 816 black and white men and women, aged 17-65 years, 711 of whom completed a 20 week aerobic exercise training program. The tHcy concentration was measured in frozen plasma samples by an HPLC method. In Blacks, tHcy did not change with exercise training [men -0.5 (SD 3.7) micromol/l, women 0.0 (2.2) micromol/l) but increased significantly in Whites (men +0.3 (1.7) micromol/l, women +0.2 (1.6) micromol/l). No sex-related differences were found in either racial group. Changes in tHcy correlated negatively with baseline homocysteine (r = -0.40, P < 0.0001). Homocysteine levels of the "High" (hyperhomocysteinemia) (>or=15 micromol/l) group (n = 30) decreased significantly with regular aerobic exercise from 23.1 (12.1) to 19.6 (7.6) micromol/l. Homocysteine levels of the "Normal" group increased slightly from 8.2 +/- 2.2 to 8.5 +/- 2.4 micromol/l. Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range.
Okura
Tomohiro
T
Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Rankinen
Tuomo
T
Gagnon
Jacques
J
Lussier-Cacan
Suzanne
S
Davignon
Jean
J
Leon
Arthur S
AS
Rao
D C
DC
Skinner
James S
JS
Wilmore
Jack H
JH
Bouchard
Claude
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001642:Bicycling / Q000502:physiology; D044383:Black People; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D003367:Cotinine / Q000097:blood; D003404:Creatinine / Q000097:blood; D005006:Ethnicity; D015444:Exercise / Q000502:physiology*; D005260:Female; D005492:Folic Acid / Q000097:blood; D005838:Genotype; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010809:Physical Fitness / Q000502:physiology*; D012727:Sex Characteristics; D014805:Vitamin B 12 / Q000097:blood; D014815:Vitamins / Q000097:blood; D049629:Waist-Hip Ratio; D044465:White People
D014815:Vitamins; D006710:Homocysteine; D005492:Folic Acid; D003404:Creatinine; D003367:Cotinine; D014805:Vitamin B 12; D010100:Oxygen