2,6-Quinolinyl derivatives as potent VLA-4 antagonists.
A new series of 2,6-quinolinyl derivatives was prepared leading to potent low nanomolar VLA-4/VCAM-1 antagonists.
Lassoie
Marie-Agnès
MA
UCB S.A., R&D, Chemin du Foriest, B-1420 Braine-l'Alleud, Belgium.
Broeders
Fabienne
F
Collart
Philippe
P
Defrère
Laurent
L
de Laveleye-Defais
Françoise
F
Demaude
Thierry
T
Gassama
Abdoulaye
A
Guillaumet
Gérald
G
Hayez
Jean-Claude
JC
Kiss
Laszlo
L
Knerr
Laurent
L
Nicolas
Jean-Marie
JM
Norsikian
Stéphanie
S
Quéré
Luc
L
Routier
Sylvain
S
Verbois
Valérie
V
Provins
Laurent
L
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors*; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D039041:Integrin alpha4beta1; D011804:Quinolines