A short enantioselective total synthesis of the phytotoxic lactone herbarumin III.
The phytotoxic lactone herbarumin III has been synthesized in 11% overall yield. The approach applied uses Keck's asymmetric allylation and Sharpless epoxidation to build the key fragment. Esterification with 5-hexenoic acid and a ring closing metathesis was used to arrive at the target.
Boruwa
Joshodeep
J
Natural Products Chemistry Division, Regional Research Laboratory (CSIR), Jorhat, 785 006, Assam, India.
Gogoi
Naminita
N
Barua
Nabin C
NC
D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D007783:Lactones; C477617:herbarumin III