Genetic interaction between Rb and N-ras: differentiation control and metastasis.
The retinoblastoma tumor suppressor gene, Rb, and the ras proto-oncogenes regulate various cellular processes, including differentiation and proliferation. Rb and ras genetically interact to positively influence differentiation in the mouse. This genetic interaction between Rb and ras also affects tumor development, either positively or negatively depending on cell type. Loss of one or two N-ras alleles allows medullary thyroid (C cell) adenomas occurring in Rb heterozygous mice to progress to metastatic carcinomas, an event associated with C cells displaying a less-differentiated phenotype. Here, we discuss the genetic interaction between Rb and ras and the development of a mouse model of medullary thyroid carcinoma.
Takahashi
Chiaki
C
The 21st Century Center of Excellence Program, Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ewen
Mark E
ME
D000818:Animals; D018276:Carcinoma, Medullary / Q000235:genetics / Q000628:therapy; D002453:Cell Cycle / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D047108:Embryonic Development / Q000235:genetics; D005786:Gene Expression Regulation; D016161:Genes, Retinoblastoma; D011905:Genes, ras; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009362:Neoplasm Metastasis / Q000235:genetics*; D015689:Oncogene Protein p21(ras) / Q000502:physiology*; D016283:Proto-Oncogene Proteins p21(ras) / Q000502:physiology*; D051381:Rats; D016160:Retinoblastoma Protein / Q000502:physiology*; D013964:Thyroid Neoplasms / Q000235:genetics / Q000628:therapy
D016160:Retinoblastoma Protein; D015689:Oncogene Protein p21(ras); D016283:Proto-Oncogene Proteins p21(ras)