Continuous venovenous hemodiafiltration to treat controlled-release carbamazepine overdose in a pediatric patient.
Carbamazepine (CBZ) intoxication is an important issue in acute poisoning practice. Highly protein-bound, CBZ is not removed efficiently through conventional hemodialysis. We describe the use of continuous venovenous hemodiafiltration (CVVHDF) in a 2-year-old boy who developed general tonic clonic seizure and respiratory depression due to controlled-release formula of CBZ overdose (peak drug level of > 20 microg.ml(-1), therapeutic range: 5-10 microg.ml(-1)). Serum CBZ concentrations fell to 0.25 microg.ml(-1) at the end of hemodiafiltration. The patient recovered rapidly and was discharged from hospital 4 days from the time of ingestion with no complications or neurologic impairment.
Yildiz
Tulay Sahin
TS
Department of Anaesthesiology, School of Medicine, University of Kocaeli, Kocaeli, Turkey. tulaysahin00@yahoo.com
Toprak
Demet Gedikbasi
DG
Arisoy
Emin Sami
ES
Solak
Mine
M
Toker
Kamil
K
D000927:Anticonvulsants / Q000506:poisoning*; D002220:Carbamazepine / Q000506:poisoning*; D002675:Child, Preschool; D003692:Delayed-Action Preparations / Q000506:poisoning; D062787:Drug Overdose / Q000628:therapy; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D008297:Male
D000927:Anticonvulsants; D003692:Delayed-Action Preparations; D002220:Carbamazepine