In vivo glucose measurement by surface-enhanced Raman spectroscopy.
This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used to obtain quantitative in vivo glucose measurements from an animal model. Silver film over nanosphere surfaces were functionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague-Dawley rat such that the glucose concentration of the interstitial fluid could be measured by spectroscopically addressing the sensor through an optical window. The sensor had relatively low error (RMSEC = 7.46 mg/dL (0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).
Stuart
Douglas A
DA
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
Yuen
Jonathan M
JM
Shah
Nilam
N
Lyandres
Olga
O
Yonzon
Chanda R
CR
Glucksberg
Matthew R
MR
Walsh
Joseph T
JT
Van Duyne
Richard P
RP
D000818:Animals; D004563:Electrochemistry; D005947:Glucose / Q000032:analysis* / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods*; D013499:Surface Properties; D013997:Time Factors
D005947:Glucose