title: Cucurbitane glycosides from unripe fruits of Lo Han Kuo (Siraitia grosvenori).
abstract: From the unripe fruits of Lo Han Kuo (Siraitia grosvenori), a Chinese medicinal plant, two new cucurbitane triterpene glycosides, 20-hydroxy-11-oxomogroside IA(1) (1) and 11-oxomogroside IIE (2), were isolated along with five known cucurbitane glycosides, 11-oxomogroside IA(1) (3), mogroside IIE (4), mogroside III (5), mogroside IVA (6), and mogroside V (7), and two flavonoid glycosides, kaempferol 7-O-alpha-L-rhamnopyranoside (8) and kaempferol 3,7-di-O-alpha-L-rhamnopyranoside (9). Their structures were determined on the basis of detailed analyses of 1D, 2D-NMR spectroscopic methods and by comparing with literature values. This paper describes the first investigation of unripe bitter Lo Han Kuo fruits.
authors.affiliation: Faculty of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Dianpeng
authors.initials: D
authors.lastname: Li
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Nanae
authors.initials: N
authors.lastname: Matsuoka
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
authors.forename: Hourui
authors.initials: H
authors.lastname: Zhang
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Gen-Ichiro
authors.initials: G
authors.lastname: Nonaka
mesh_terms: D019662:Cucurbitaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D014315:Triterpenes; C514277:cucurbitane