[Lipometabolic disorder--cholesterol and triglycerides].
Resorption inhibitors for cholesterol are commonly applied today in case of hypercholesterolemia in addition to statins. This combination therapy reduces the value of the LDL concentration by 50-60%. A target value of 100 mg/dl should be adjusted in case of high-risk patients in order to also decrease coronary risk. The significance of the triglycerides level is also becoming increasingly important, for it describes a high cardiovascular risk due to an increase of adiposity and diabetes. Such a dysfunction in storage and release of fatty lipids from triglycerides is treated dependent on severity: Patients with slightly elevated values (> 200 mg/dl) should change their habits (e.g. balanced diet, abstinance of alcohol, exercise) if necessary followed by application of fibrates, omega-3 fatty acids or nicotinic acid. These medicamentous measures are inevitable and must be applied immediately in case patients having values >1000 mg/dl.
Luley
C
C
Otto-von-Guericke-Universität Magdeburg, Institut für Klinische Chemie und Pathobiochemie, Leipziger Str. 44, 39120 Magdeburg, Germany.
D008078:Cholesterol, LDL / Q000097:blood; D003131:Combined Modality Therapy; D038321:Glycemic Index; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000188:drug therapy; D015228:Hypertriglyceridemia / Q000150:complications* / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008019:Life Style; D009203:Myocardial Infarction / Q000097:blood / Q000517:prevention & control*; D012307:Risk Factors; D055502:Secondary Prevention; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D014280:Triglycerides