Molecular targets of tea polyphenols in the cardiovascular system.
Tea-derived polyphenols have attracted considerable attention in the prevention of cancer and cardiovascular diseases. In comparison to tumour cells, the elucidation of their molecular targets in cardiovascular relevant cells is still at the beginning. Although promising experimental and clinical data demonstrate protective effects for the cardiovascular system, little information is actually available on how these beneficial effects of tea polyphenols are mediated at the cellular level. By affecting the activity of receptor and signal transduction kinases, both catechins and theaflavins--the major ingredients of green and black tea, respectively--exert a variety of cardiovascular beneficial effects. In general, the number and positions of galloyl groups have major influence on the potency of polyphenols. Compared to their broad impact on cellular signal transduction, tea polyphenols reveal little transcriptional effects. However, more detailed and profound analysis of molecular actions in different cells of the cardiovascular system is necessary before safe clinical use of tea polyphenols for treatment of cardiovascular diseases will become possible.
Stangl
Verena
V
Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charité-Universitätsmedizin Berlin, CCM, Schumannstrasse 20-21, D-10117 Berlin, Germany. verena.stangl@charite.de
Dreger
Henryk
H
Stangl
Karl
K
Lorenz
Mario
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D009389:Neovascularization, Pathologic; D010636:Phenols / Q000737:chemistry / Q000378:metabolism*; D059808:Polyphenols; D013662:Tea; D013927:Thrombosis / Q000517:prevention & control
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea