[Prevention of osteoporosis by foods and dietary supplements. Hesperidin and bone metabolism].
Among the naturally occurring citrus flavonoids, hesiperidin, a flavanon glycocide, may be associated with potential benefits in the prevention of diseases, such as decreasing capillary permeability, anti inflammatory, antimicrobial and anti carcinogenic effects. Hesperidin also regulates hepatic cholesterol synthesis by inhibiting the activity of 3-hydroxy-3-methlyglutaryl coenzyme A (HMG-CoA) reductase. Recently, Mundy et al. reported that statins, cholesterol lowering agents, induce bone formation and inhibit bone resorption both in vitro and in vivo. Thus, considerable attention has focused on the relationship between the inhibitory activity on HMG-CoA reductase and bone action. We examined the effects of hesperidin on bone metabolism in ovariectomized mice, orhiectomized mice and magnesium deficient rats, animal models of osteoporosis. Hesperidin inhibited bone loss the animals with lowering serum and hepatic cholesterol. These results suggest hesperidin may act on bone by the same mechanism as that of statins. Further studies are needed to define hesperidin's mechanisms of action on bone.
Uehara
Mariko
M
Tokyo University of Agriculture, Faculty of Applied Bio-Science, Department of Nutritional Science.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D006569:Hesperidin / Q000494:pharmacology*; D051379:Mice; D010024:Osteoporosis / Q000378:metabolism; D051381:Rats
D005419:Flavonoids; D006569:Hesperidin