title: Nanotopography: cellular responses to nanostructured materials.
abstract: Several in vitro and in vivo experiments have shown that nanostructured materials, which mimic the nanometer topography of the native tissues, improve biocompatible responses, and result in better tissue integration in medical implants. Understanding various aspects of nanotopography is extremely important for better designs of these devices. In this review paper, recent progress in the fabrication, characterization, biological responses, and application of nanostructured materials are discussed. Specifically, materials such as ceramics and polymers used to manufacture nanostructured surfaces are briefly introduced. Techniques for fabrication and characterization of nanostructured materials are also explored. Cellular responses such as morphology, alignment, adhesion, proliferation, and profiles of gene expression of various cell types after their exposure to nanofeatured materials are particularly reviewed. Finally, the paper briefly discusses some application of nanostructured materials including those in biosensor and tissue engineering fields.
authors.affiliation: Department of Biological and Irrigation Engineering, Biological Engineering Program, Utah State University, Logan 84322, USA.
authors.forename: Rammohan
authors.initials: R
authors.lastname: Kriparamanan
authors.forename: Pranesh
authors.initials: P
authors.lastname: Aswath
authors.forename: Anhong
authors.initials: A
authors.lastname: Zhou
authors.forename: Liping
authors.initials: L
authors.lastname: Tang
authors.forename: Kytai T
authors.initials: KT
authors.lastname: Nguyen
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D002468:Cell Physiological Phenomena; D016764:Cell Polarity; D049109:Cell Proliferation; D002470:Cell Survival; D008422:Materials Testing / Q000379:methods; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods
chemical_list: D001672:Biocompatible Materials