title: Intelligent fluorescent nucleoside in sensing cytosine base: importance of hydrophobic nature of perylene fluorophore.
abstract: Fluorescence response upon hybridization of perylene labeled oligonucleotide probes depends on the microenvironment experienced by the perylene fluorophore. In mismatched duplex ((Per)U-C), enhanced fluorescence was observed while in matched duplex ((Per)U-A) fluorescence intensity decreased considerably. This observation will be a promising research effort in giving rise to a new powerful tool in detection of SNP.
authors.affiliation: NEWCAT Institute, School of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan.
authors.forename: Subhendu Sekhar
authors.initials: SS
authors.lastname: Bag
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Saito
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hanawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kodate
authors.forename: Isamu
authors.initials: I
authors.lastname: Suzuka
authors.forename: Isao
authors.initials: I
authors.lastname: Saito
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D003596:Cytosine / Q000032:analysis*; D005456:Fluorescent Dyes; D009711:Nucleotides; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D010569:Perylene; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D009711:Nucleotides; D009838:Oligodeoxyribonucleotides; D010569:Perylene; D003596:Cytosine