A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex.
Beta2 frequency (20-30 Hz) oscillations appear over somatosensory and motor cortices in vivo during motor preparation and can be coherent with muscle electrical activity. We describe a beta2 frequency oscillation occurring in vitro in networks of layer V pyramidal cells, the cells of origin of the corticospinal tract. This beta2 oscillation depends on gap junctional coupling, but it survives a cut through layer 4 and, hence, does not depend on apical dendritic electrogenesis. It also survives a blockade of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors or a blockade of GABA(A) receptors that is sufficient to suppress gamma (30-70 Hz) oscillations in superficial cortical layers. The oscillation period is determined by the M type of K+ current.
Roopun
Anita K
AK
Medical School, University of Newcastle, Newcastle NE2 4HH, United Kingdom.
Middleton
Steven J
SJ
Cunningham
Mark O
MO
LeBeau
Fiona E N
FE
Bibbig
Andrea
A
Whittington
Miles A
MA
Traub
Roger D
RD
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001611:Beta Rhythm; D018690:Excitatory Amino Acid Agonists / Q000378:metabolism; D017629:Gap Junctions / Q000378:metabolism; D007608:Kainic Acid / Q000378:metabolism; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism
D018690:Excitatory Amino Acid Agonists; D011963:Receptors, GABA-A; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007608:Kainic Acid