title: Immunohistochemical study of the relationship between Ki-67 labeling index of proliferating cells of gynecomastia, histological phase and duration of disease.
abstract: Gynecomastia is a benign proliferative lesion caused by various etiological factors and may result from a relative imbalance between serum estrogen and androgen levels. The histological alterations are similar, and gynecomastia can progress from a florid type to a fibrous type. The Ki-67 labeling index (LI) of gynecomastia specimen was investigated and higher Ki-67 LI was observed in florid and intermediate than in fibrous gynecomastia (P = 0.017). A correlation was found between the duration of disease and Ki-67 LI (P = 0.041): the shorter the duration the higher the Ki-67 LI. Thus, Ki-67 LI seems a useful tool to examine proliferation activity of gynecomastia and can assist in determination of appropriate treatment of gynecomastia with hormonal therapy.
authors.affiliation: Department of Pathology, Saitama Cancer Center, Ina-machi, Saitama, Japan.
authors.forename: Seishi
authors.initials: S
authors.lastname: Kono
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kurosumi
authors.forename: Hanako
authors.initials: H
authors.lastname: Simooka
authors.forename: Kaori
authors.initials: K
authors.lastname: Kawanowa
authors.forename: Jun
authors.initials: J
authors.lastname: Ninomiya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takei
authors.forename: Kimito
authors.initials: K
authors.lastname: Suemasu
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D019084:Fluorescent Antibody Technique, Indirect; D006177:Gynecomastia / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone