Synthesis and antibacterial activity of nitroaryl thiadiazole-levofloxacin hybrids.
Novel levofloxacin-containing hybrids carrying a 5-(nitroaryl)-1,3,4-thiadiazol-2-yl group were synthesized and evaluated in vitro against Gram-positive and Gram-negative bacteria. Preliminary data indicated that levofloxacin-nitrofuran and levofloxacin-nitroimidazole hybrids have a potent activity against Gram-positive organisms with enhanced anti-staphylococcal activity compared with the parent quinolone (N-desmethyl levofloxacin).
Foroumadi
Alireza
A
Department of Microbiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran. aforoumadi@yahoo.com
Mansouri
Shahla
S
Emami
Saeed
S
Mirzaei
Javad
J
Sorkhi
Maedeh
M
Saeid-Adeli
Nosratollah
N
Shafiee
Abbas
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013830:Thiadiazoles; D064704:Levofloxacin; D015242:Ofloxacin