Radioimmunoscintigraphy of colorectal carcinomas with three different radiopharmaceuticals.
The aim of the study was evaluation of the clinical reliability of the immunoscintigraphy for the detection of metastases and recurrences of colorectal carcinomas using three different radiopharmaceutical substances. With IMACIS 1, the number of true negative findings (TN) was 4/7 and true positive (TP) 3/7, while in one patient, the results of immunoscintigraphy significantly influenced the therapeutical management. With INDIMACIS 19-9, there were 2/8 TN and 6/8 TP. In three patients, immunoscintigraphy results influenced patient further management. With ONCOSCINT in 2 patients findings were TN, in one FN and in one FP. In 3 patients, immunoscintigraphy influenced the management of the patient. Other imaging methods (CT, US, MRI) have advantage in detection of liver metastases, while immunoscintigraphy is more specific for the assessment of reccurences of the abdominal tumors. Thus immunoscintigraphy should be applied in patients with suggested recurrences and inconclusive outcome of routine diagnostic workup.
Obradovic
V
V
Institute of Nuclear Medicine, Clinical Center of Serbia, 11000 Beograd, Serbia and Montenegro. vladimir.obradovic@kcs.ac.yu
Artiko
V
V
Petrovic
M
M
Lausevic
Z
Z
Stojkovic
M
M
Sobic-Saranovic
D
D
Petrovic
N
N
Vlajkovic
M
M
Krivokapic
Z
Z
D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000911:Antibodies, Monoclonal; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D016719:Radioimmunodetection / Q000379:methods*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity
D000911:Antibodies, Monoclonal; C057468:Imacis-1; D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals