Poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide)-g-poly(1,3trimethylene carbonate) amphiphilic graft co-polymer as a potential drug carrier.
A biodegradable amphiphilic graft polymer was successfully synthesized by grafting hydrophobic poly(1,3-trimethylene carbonate) (PTMC) sequences onto a hydrophilic poly-alpha,beta-(N-(2-hydroxyethyl)-L-aspartamide) (PHEA) backbone. The graft polymer, PHEA-g-PTMC, was synthesized by ring-opening polymerization initiated by the macroinitiator PHEA bearing hydroxyl groups without adding any catalyst. The graft polymer was characterized by Fourier transform infrared spectroscopy, 1H-nuclear magnetic resonance spectroscopy, combined size-exclusion chromatography and multiangle laser light scattering analysis. Two drugs with distinct water solubility, prednisone acetate and tegafur, were encapsulated in the PHEA-g-PTMC nanoparticles. The in vitro release of two drugs from PHEA-g-PTMC nanoparticle drug-delivery systems was investigated.
Peng
Tao
T
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P R. China.
Su
Jing
J
Cheng
Si-Xue
SX
Zhuo
Ren-Xi
RX
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D004146:Dioxanes / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D049329:Nanostructures; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D011241:Prednisone / Q000008:administration & dosage; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents; D005641:Tegafur / Q000008:administration & dosage
D001672:Biocompatible Materials; D004146:Dioxanes; D004337:Drug Carriers; D010455:Peptides; D011108:Polymers; D013501:Surface-Active Agents; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide); D005641:Tegafur; C059299:polytrimethylene carbonate; D011241:Prednisone