title: Cognitive function in adults with type 2 diabetes and major depression.
abstract: The aim of this study was to identify characteristics of neuropsychological functioning among type 2 diabetic adults with and without major depression. Twenty type 2 diabetics with major depression, 20 non-depressed type 2 diabetics and 34 controls without diabetes or depression were compared. A mixed effects repeated measures analysis of covariance indicated significant differences in overall cognitive functioning between diagnostic groups, specifically depressed diabetics demonstrated greater cognitive dysfunction than controls. Further comparisons indicated that depressed diabetics performed significantly worse than non-depressed diabetics in attention/information processing speed. Relative to controls, depressed diabetics performed significantly worse in attention/information processing speed and executive functioning, while there was a trend for non-depressed diabetics to perform worse in executive functioning. These findings suggest that depression negatively impacts cognitive performance among adults with type 2 diabetes, which may have implications for neural circuitry underlying cognitive and mood changes in diabetic patients.
authors.affiliation: Division of Geriatric Psychiatry, UCLA Semel Institute & Resnick Neuropsychiatric Hospital, 760 Westwood Plaza, 37-372A, Los Angeles, CA 90024-1759, United States. kwatari@mednet.ucla.edu
authors.forename: Kecia
authors.initials: K
authors.lastname: Watari
authors.forename: Andrea
authors.initials: A
authors.lastname: Letamendi
authors.forename: Virginia
authors.initials: V
authors.lastname: Elderkin-Thompson
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Haroon
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Miller
authors.forename: Christine
authors.initials: C
authors.lastname: Darwin
authors.forename: Anand
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D003865:Major Depressive Disorder / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D013028:Space Perception / Q000502:physiology