Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease.
Monoamine oxidase (MAO) is an enzyme regulating metabolism of neurotransmitters such as dopamine. Two distinct forms of enzyme, encoded by genes MAOA and MAOB located on the X chromosome, have been considered as possible factors in the pathogenesis of Parkinson disease (PD). Previous association studies of PD and MAO genes reported inconsistent results. In this study, we used a large family-based data set to test associations between MAO genes and a risk of PD. The data set includes 298 female discordant sibpairs and 348 male discordant sibpairs. For this study, all subjects analyzed were white and families with known parkin mutations were removed. We analyzed 15 single nucleotide polymorphisms (SNPs) and a dinucleotide repeat marker in the MAO genes. Association was found with the intron 13 SNP of MAOB in the female subset (P = 0.02). No significant association was found in the male subset. Our results add to the evidence of involvement of MAOB in PD and suggest that the effect may be stronger in women.
Kang
Sun J
SJ
Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA.
Scott
William K
WK
Li
Yi-Ju
YJ
Hauser
Michael A
MA
van der Walt
Joelle M
JM
Fujiwara
Kenichiro
K
Mayhew
Gregory M
GM
West
Sandra G
SG
Vance
Jeffery M
JM
Martin
Eden R
ER
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D041321:Chromosomes, Human, X; D016001:Confidence Intervals; D005192:Family Health; D005260:Female; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors
D008995:Monoamine Oxidase