Stereocontrolled synthesis of highly functionalized spirocyclic pyrans.
Highly functionalized spirocyclic pyrans can be obtained through the Achmatowicz rearrangement of furyl carbinols by taking advantage of the different rates of reaction for epoxidation and nucleophilic addition. Through this methodology, spirocyclic units of various ring sizes can be selectively generated with complete stereocontrol.
Hobson
Stephen J
SJ
WestCHEM, Department of Chemistry, University of Glasgow, Glasgow, UK.
Marquez
Rodolfo
R
D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D011714:Pyrans; D013141:Spiro Compounds