Cooperative binding and multiple recognition by bridged bis(beta-cyclodextrin)s with functional linkers.
Possessing two beta-cyclodextrin cavities in close vicinity and a functional linker with good structural variety in a single molecule, bridged bis(beta-cyclodextrin)s can significantly enhance the original binding ability and molecular selectivity of native beta-cyclodextrin and thus be successfully utilized in drug carriers, solubilizers, catalysis, photochemical materials, etc. This Account describes recent developments in the intramolecular cooperative binding and multiple recognition of bridged bis(beta-cyclodextrin)s with functional linkers in solution, as well as their molecular assembly behaviors through the intermolecular cooperative binding. It also gives a description of unique properties and wide applications of bis(beta-cyclodextrin)s and their assemblies.
Liu
Yu
Y
Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China. yuliu@nankai.edu.cn
Chen
Yong
Y
D001665:Binding Sites; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D008958:Models, Molecular; D012996:Solutions; D013816:Thermodynamics; D047392:beta-Cyclodextrins / Q000737:chemistry*
D001952:Bridged-Ring Compounds; D012996:Solutions; D047392:beta-Cyclodextrins