Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains.
The pharmacokinetic profile of linezolid in cerebrospinal fluid (CSF) in five neurointensive care patients with staphylococcal ventriculitis was studied. The mean area under concentration-time curve (+/- standard deviation) was 63 +/- 18.9 mg x h/liter, with a CSF-to-plasma ratio of 0.8 +/- 0.3. Times above MIC in CSF were 99.8% and 57.2% for pathogens with MICs of 2 mg/liter and 4 mg/liter, respectively.
Beer
Ronny
R
Innsbruck Medical University, Clinical Department of Neurology, Neurological Intensive Care Unit, Anichstrasse 35, 6020 Innsbruck, Austria. ronny.beer@uibk.ac.at
Engelhardt
Klaus W
KW
Pfausler
Bettina
B
Broessner
Gregor
G
Helbok
Raimund
R
Lackner
Peter
P
Brenneis
Christian
C
Kaehler
Stefan T
ST
Georgopoulos
Apostolos
A
Schmutzhard
Erich
E
D000081:Acetamides / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D002552:Cerebral Ventricles / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D004660:Encephalitis / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D000069349:Linezolid; D008297:Male; D008657:Metabolic Clearance Rate; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D023303:Oxazolidinones / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects*
D000081:Acetamides; D023303:Oxazolidinones; D000069349:Linezolid