Radiation induced dynamic mutations and transgenerational effects.
Many studies have confirmed that radiation can induce genomic instability in whole body systems. Although the molecular mechanisms underlying induced genomic instability are not known at present, this interesting phenomenon could be the manifestation of a cellular fail-safe system in which fidelity of repair and replication is down-regulated to tolerate DNA damage. Two features of genomic instability namely, delayed mutation and untargeted mutation, require two mechanisms of ;damage memory' and ;damage sensing, signal transduction and execution' to induce mutations at a non damaged-site. In this report, the phenomenon of transgenerational genomic instability and possible mechanisms are discussed using mouse data collected in our laboratory as the main bases.
Niwa
Ohtsura
O
Kyoto University Radiation Biology Center, Kyoto, Japan. oniwa@house.rbc.kyoto-u.ac.jp
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D005260:Female; D042822:Genomic Instability; D006801:Humans; D008297:Male; D051379:Mice; D018598:Minisatellite Repeats; D008957:Models, Genetic; D016296:Mutagenesis; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000378:metabolism; D011247:Pregnancy; D011833:Radiation Injuries, Experimental / Q000235:genetics* / Q000378:metabolism; D016196:S Phase / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016159:Tumor Suppressor Protein p53