title: The benefits of early intervention in obese diabetic patients with FBCx: a new dietary fibre.
abstract: BACKGROUND
  Obesity and diabetes have become epidemic in the US. Dietary fibres have been reported to reduce the absorption of dietary fat, prevent weight gain, and reduce blood lipid levels. In the current double-blind study, obese patients with type 2 diabetes were recruited for a 3-month study to examine the health effects of a new dietary fibre, FBCx.
  
  
  METHODS
  Sixty-six participants were recruited and were randomized into FBCx or placebo groups. They were instructed to take two 1-g tablets per fat-containing meal and not to change their eating patterns or daily routine. Three-day dietary records and fasting blood samples were collected prior to enrollment in the study and at the end of months 1, 2 and 3.
  
  
  RESULTS
  Dietary records showed that some participants changed their eating patterns; therefore body weight data were adjusted according to energy intake. As a group, in the 30 days leading into the study, all participants experienced an average weight gain of 1.0 +/- 0.4 kg, while those in the placebo group continued to gain weight during the study, those in the FBCx group maintained their weight. Those in the FBCx group required more energy to maintain their body weight while those in the placebo group required less (p < 0.05). Participants with hypertriglyceridemia showed a reduction (-0.48 +/- 0.24 mmol/L, - 8.2%) in total cholesterol with FBCx, while those with placebo had an increase (0.24 +/- 0.21 mmol/L, 5.2%, p < 0.05). Adiponectin was increased in the FBCx but reduced in the placebo group (p < 0.05).
  
  
  CONCLUSIONS
  FBCx has thus shown promising benefits in weight maintenance, a reduction of blood lipids and an increase in adiponectin levels. It can be easily incorporated into a diabetic management regimen.
authors.affiliation: Grunberger Diabetes Institute, Bloomfield Hills, MI 48302, USA. grunberger@gdi-pc.com
authors.forename: George
authors.initials: G
authors.lastname: Grunberger
authors.forename: K-L Catherine
authors.initials: KL
authors.lastname: Jen
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Artiss
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000178:diet therapy*; D004043:Dietary Fiber / Q000627:therapeutic use*; D004311:Double-Blind Method; D002149:Energy Intake; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000178:diet therapy*; D014280:Triglycerides / Q000097:blood; D047391:alpha-Cyclodextrins / Q000627:therapeutic use*
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D007328:Insulin; D014280:Triglycerides; D047391:alpha-Cyclodextrins; D002784:Cholesterol