title: Bioavailability, antioxidant and immune-enhancing properties of zinc methionine.
abstract: Although a large number of transition metals and cations remarkably induce oxidative deterioration of biological macromolecules including lipids, proteins and DNA, the trace element zinc acts as a novel dietary supplement and an essential micronutrient, and serves a wide range of biological functions in human and animal health. Zinc promotes antioxidant and immune functions, stabilizes and maintains the structural integrity of biological membranes, and plays a pivotal role in skin and connective tissue metabolism and repair. Zinc is an integral constituent of a large number of enzymes including antioxidant enzymes, and hormones including glucagon, insulin, growth hormone, and sex hormones. High concentrations of zinc are found in the prostate gland and choroids of the eye. Zinc deficiency leads to biochemical abnormalities including the impairments of growth, dermal, gastrointestinal, neurologic and immunologic systems. Given its superior bioavailability, antioxidant and immune-enhancing properties, zinc methionine may serve as a novel dietary supplement to promote health benefits in humans and animals.
authors.affiliation: InterHealth Research Center, Benicia, CA, USA.
authors.forename: Xiaoming Xu
authors.initials: XX
authors.lastname: Chien
authors.forename: Shirley
authors.initials: S
authors.lastname: Zafra-Stone
authors.forename: Manashi
authors.initials: M
authors.lastname: Bagchi
authors.forename: Debasis
authors.initials: D
authors.lastname: Bagchi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D019587:Dietary Supplements; D006293:Health Promotion / Q000379:methods; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D008715:Methionine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D009942:Organometallic Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D015032:Zinc / Q000008:administration & dosage; D017967:Zinc Compounds / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D009942:Organometallic Compounds; D017967:Zinc Compounds; C074508:zinc methionine; D008715:Methionine; D015032:Zinc