title: [Identification of propionibacterium acnes in a case with stage III pulmonary sarcoidosis involving hepatosplenic disease].
abstract: A 35-year-old woman was admitted to our hospital because of an abnormal chest radiograph. Chest X-ray on admission showed multiple small nodular shadows in both lung fields but no bilateral hilar lymphadenopathy (BHL). Moreover, abdominal CT showed some nodules in the liver and spleen, and serum ACE was slightly increased to 23.3U/L (normal range: 8.3-21.4U/L). Transbronchial lung biopsy and liver biopsy resulted in a diagnosis of stage III pulmonary sarcoidosis with hepatosplenic disease. Histopathological findings demonstrated non-caseating epithelioid cell granulomas with giant cells in both specimens. Interestingly, propionibacterium acnes (P. acnes), the possible pathogen of sarcoidosis, was detected in giant cells in the lung and epitheliod cell granuloma of liver tissue. This case was of interest considering P. acnes might have been the causative pathogen.
authors.affiliation: First Department of Internal Medicine, Tokyo Medical University.
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohta
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Tetuya
authors.initials: T
authors.lastname: Abe
authors.forename: Eri
authors.initials: E
authors.lastname: Kurakawa
authors.forename: Jinho
authors.initials: J
authors.lastname: Park
authors.forename: Miki
authors.initials: M
authors.lastname: Izumi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Eishi
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Setoguchi
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D011425:Propionibacterium acnes / Q000276:immunology* / Q000472:pathogenicity; D013902:Radiography, Thoracic; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging / Q000209:etiology* / Q000382:microbiology; D013158:Splenic Diseases / Q000150:complications*; D014057:Tomography, X-Ray Computed
chemical_list: D000907:Antibodies, Bacterial