title: A new cyclotetrapeptide from marine fungus Trichoderma reesei.
abstract: A new cyclotetrapeptide, trichoderide A, was isolated from the marine fungus Trichoderma reesei. The structure was identified by spectral methods, and the stereochemical assignments were made by chiral HPLC of the hydrolyzed compound. Trichoderide A showed moderate cytotoxity against human A375-S2 melanoma cell line.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Yong-Fu
authors.initials: YF
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Sha
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental / Q000188:drug therapy; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; D013778:Tetrazolium Salts; D013844:Thiazoles; C514447:trichoderide A; C022616:thiazolyl blue