Activation of extracellular signal-regulated kinase signaling by chronic electroconvulsive shock in the rat frontal cortex.
The effects of chronic electroconvulsive shock (ECS), given daily for 1, 5 and 10 days, on the activation of extracellular signal-regulated kinase (ERK) were studied in the rat frontal cortex. The phosphorylation of MEK1/2 and ERK1/2 increased through 5 days of ECS. Thereafter, a plateau was achieved. The expression of brain-derived neurotrophic factor was continuously increased for 10 days. Our data show that the effect of ECS on ERK1/2 signaling is increased with chronic treatment.
Kang
Ung Gu
UG
Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, and Institute of Human Behavioral Medicine, Seoul National University, Seoul, Korea.
Koo
Young Jin
YJ
Jeon
Won Je
WJ
Park
Doo Byung
DB
Juhnn
Yong Sung
YS
Park
Joo Bae
JB
Kim
Yong Sik
YS
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D004597:Electroshock; D004789:Enzyme Activation / Q000502:physiology; D005625:Frontal Lobe / Q000473:pathology*; D015151:Immunoblotting; D048369:MAP Kinase Kinase 1; D048730:MAP Kinase Kinase Kinase 2 / Q000378:metabolism; D008297:Male; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology
D019208:Brain-Derived Neurotrophic Factor; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048730:MAP Kinase Kinase Kinase 2; D048369:MAP Kinase Kinase 1; C482125:MAP2K1 protein, human