Why don't we have a schistosomiasis vaccine?
Over the past 30 years there has been a concerted effort to understand host immune responses to schistosomes, with the ultimate aim of producing a vaccine for human use. In this issue, Bergquist and Colley, in summarizing recent meetings in Cairo, provide a detailed appraisal of progress towards that goal. It seems an appropriate time to ask why, with reference to Schistosoma mansoni, the development of a vaccine has proved so difficult. This question is explored here by Alan Wilson and Pat Coulson.
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Coulson
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