title: Preoperative chemoradiotherapy for esophageal cancer enhances the postoperative systemic inflammatory response.
abstract: BACKGROUND
  Chemoradiotherapy (CRT) has been established to improve the long-term survival in patients with esophageal carcinoma. However, little is known about whether preoperative CRT may affect the postoperative systemic response.
  
  
  METHODS
  We investigated the postoperative clinical course in terms of the systemic inflammatory response syndrome (SIRS) in patients with preoperative CRT (CRT group) and surgery alone (SA group).
  
  
  RESULTS
  Both the postoperative heart and respiratory rate in the CRT group were significantly higher than in the SA group. The duration and incidence of SIRS, as well as the number of positive criteria for SIRS, were significantly greater than those in the SA group. There was no difference in the postoperative morbidity and mortality between the two groups.
  
  
  CONCLUSIONS
  Preoperative CRT was found to significantly enhance the postoperative SIRS, thus suggesting its potentially higher risk of complications.
authors.affiliation: Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan. Tsujiflorida@aol.com
authors.forename: Hironori
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ono
authors.forename: Kentaro
authors.initials: K
authors.lastname: Chochi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Sugasawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichikura
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Mochizuki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006339:Heart Rate; D006801:Humans; D007902:Length of Stay; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D012119:Respiration; D012306:Risk; D018746:Systemic Inflammatory Response Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology
chemical_list: D002945:Cisplatin; D005472:Fluorouracil