title: Genetic, physiologic and ecogeographic factors contributing to variation in Homo sapiens: Homo floresiensis reconsidered.
abstract: A new species, Homo floresiensis, was recently named for Pleistocene hominid remains on Flores, Indonesia. Significant controversy has arisen regarding this species. To address controversial issues and refocus investigations, I examine the affinities of these remains with Homo sapiens. Clarification of problematic issues is sought through an integration of genetic and physiological data on brain ontogeny and evolution. Clarification of the taxonomic value of various 'primitive' traits is possible given these data. Based on this evidence and using a H. sapiens morphological template, models are developed to account for the combination of features displayed in the Flores fossils. Given this overview, I find substantial support for the hypothesis that the remains represent a variant of H. sapiens possessing a combined growth hormone-insulin-like growth factor I axis modification and mutation of the MCPH gene family. Further work will be required to determine the extent to which this variant characterized the population.
authors.affiliation: Human Evolution Research Center, University of California, Berkeley, CA 94720, USA. grichards@berkeley.edu
authors.forename: Gary D
authors.initials: GD
authors.lastname: Richards
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D001210:Asia, Southeastern; D044383:Black People; D001827:Body Height; D001921:Brain / Q000254:growth & development; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D004392:Dwarfism / Q000235:genetics; D049690:History, Ancient; D015186:Hominidae / Q000033:anatomy & histology / Q000235:genetics; D019382:Human Growth Hormone / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008831:Microcephaly / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D017451:Receptors, Somatomedin / Q000172:deficiency; D012886:Skull / Q000033:anatomy & histology; D006801:Humans
chemical_list: C467202:ASPM protein, human; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; C460645:MCPH1 protein, human; D009419:Nerve Tissue Proteins; D017451:Receptors, Somatomedin