title: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57BL/6 mice.
abstract: Acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of Leishmania major-infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to L. major in the face of immune suppression.
authors.affiliation: Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80126, USA. owen.bowers@uchsc.edu
authors.forename: Owen J
authors.initials: OJ
authors.lastname: Bowers
authors.forename: Kirsa B
authors.initials: KB
authors.lastname: Sommersted
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Sowell
authors.forename: Gretchen E
authors.initials: GE
authors.lastname: Boling
authors.forename: William H
authors.initials: WH
authors.lastname: Hanneman
authors.forename: Richard G
authors.initials: RG
authors.lastname: Titus
authors.forename: Gregory K
authors.initials: GK
authors.lastname: Dekrey
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D018320:Leishmania major / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000469:parasitology*; D051379:Mice; D008810:Mice, Inbred C57BL; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*
chemical_list: D000913:Antibodies, Protozoan; D016207:Cytokines; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins