title: Transitions and new dynamical states induced by noise in a multiply regulated biochemical system.
abstract: Noise-induced transitions between coexisting states, and the emergence of a new oscillatory state, are examined in a model for a multiply regulated biochemical system. For the undisturbed system, three oscillatory states, I, II, and III, coexist. It is found that noise above a critical amplitude can cause a transition between states III and II and between states III or II and state I, whereas a transition from state I to either states II or III is never observed. This indicates that the relative stability under noise perturbations is greatest for state I, and progressively less for states II and III. In addition to this transition behaviour, a purely noise-induced state is found. Under noise perturbations, the average concentration of metabolites may depend on both the time duration and amplitude of the superimposed noise. The implications of these results for understanding the in vivo behaviour of complex biochemical systems are discussed.
authors.affiliation: Centre for Nonlinear Systems in Biology, Scottish Crop Research Institute, Dundee, DD2 5DA, UK. jliu@scri.sari.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: J W
authors.initials: JW
authors.lastname: Crawford