Association of the CT gene (CA) polymorphism with BMD in osteoporotic Mexican women.
Calcitonin (CT) plays a role in the pathogenesis of osteoporosis and genetic variations in or adjacent to the CT gene may be associated with loss of bone mineral density (BMD). The correlation between a dinucleotide (cytosine-adenine) repeat polymorphism at the CT locus and BMD was examined in 70 osteoporotic women, 70 non-osteoporotic women and 500 subjects from the Mexican population. The allele A and genotype AA frequencies were significantly higher in osteoporotic women than in non-osteoporotic women (60% vs 32%; p < 0.0001 and 41% vs 14%; p = 0.0007, respectively). Genotype AA was associated with the presence of osteoporosis [odds ratio 2.58; 95% confidence interval (CI); 1.62-4.12]. Likewise, the loss of lumbar BMD and T scores were related to the presence of allele A: subjects with a single A allele displayed lower values for lumbar BMD and T score (84.02% and -1.51, respectively) than those who do not present any A allele (89.61% and -0.88, respectively). Individuals with two alleles A showed the lowest lumbar BMD and T-score values (73.77% and -2.51, respectively). Analysis of potential confounder demonstrated that aging has a significant effect on osteoporosis development (odds ratio 1.1; 95% CI; 1.1052-1.152).
Magaña
J J
JJ
Department of Genetics, National Rehabilitation Institute, Mexico DF, Mexico.
Gómez
R
R
Cisneros
B
B
Casas
L
L
Castorena
F
F
Miranda
A
A
Diez
P
P
Castro
C
C
Rubio
J
J
Valdés
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001483:Base Sequence; D015519:Bone Density / Q000235:genetics*; D002116:Calcitonin / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D018900:Dinucleotide Repeats; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D011110:Polymorphism, Genetic
D002116:Calcitonin; D004247:DNA