title: Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP.
abstract: To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage (ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma (FFP), we reviewed 45 patients with warfarin-associated ICH given FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.
authors.affiliation: Division of Critical Care Neurology, Department of Neurology,Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Sung B
authors.initials: SB
authors.lastname: Lee
authors.forename: Edward M
authors.initials: EM
authors.lastname: Manno
authors.forename: Kennith F
authors.initials: KF
authors.lastname: Layton
authors.forename: Eelco F M
authors.initials: EF
authors.lastname: Wijdicks
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects; D001803:Blood Transfusion; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control*; D018450:Disease Progression; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D010949:Plasma; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin