title: Is axillary clearance the standard of care for breast cancer patients with sentinel node involvement?
abstract: Sentinel node biopsy (SNB) has become accepted for staging the axilla in early breast cancer with avoidance of axillary lymph node dissection (ALND) in patients with negative SNB. For those with positive SNB, the standard surgical management is ALND; however, this approach is increasingly being challenged. The central problem is that it is not possible to preoperatively predict whether the SNB will be positive, and it is even more difficult to determine the likelihood of nonsentinel node positivity. Various histopathological features indicate increased risk of nonsentinel node metastasis, including size of SNB metastasis, presence of lymphovascular invasion, multifocality, number of involved sentinel nodes and, conversely, the number of negative sentinel nodes. These features have been combined to produce predictive nomograms but, understandably, these still lack precision. Presently, the decision to avoid ALND will depend upon both the clinician and the patient's impression of risk, but if either requires assurance that no residual axillary disease remains, a completion clearance will be required.
authors.affiliation: Guy's Hospital, Hedley Atkins Breast Unit, London, SE1 9RT, UK. ian.fentiman@gstt.nhs.uk
authors.forename: Ian S
authors.initials: IS
authors.lastname: Fentiman
mesh_terms: D001365:Axilla / Q000473:pathology*; D001943:Breast Neoplasms / Q000628:therapy*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008197:Lymph Node Excision / Q000639:trends*; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012307:Risk Factors; D021701:Sentinel Lymph Node Biopsy / Q000639:trends*