Development of daptomycin resistance in a bone marrow transplant patient with vancomycin-resistant Enterococcus durans.
Daptomycin has demonstrated antibacterial activity against several antibiotic-resistant strains, including vancomycin-resistant enterococci. A paucity of data exists concerning in vivo development of daptomycin resistance of enterococci. We describe an allogeneic bone marrow transplant patient, who was found to have vancomycin-resistant Enterococcus durans bacteremia, which subsequently developed resistance to daptomycin.
Green
Myke R
MR
Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. greenmr@moffitt.ust.edu
Anasetti
Claudio
C
Sandin
Ramon L
RL
Rolfe
Nancy E
NE
Greene
John N
JN
D016026:Bone Marrow Transplantation; D017576:Daptomycin / Q000494:pharmacology* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology*; D016983:Enterococcus / Q000145:classification / Q000187:drug effects*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance
D014640:Vancomycin; D017576:Daptomycin