title: Ion-induced biomolecular radiation damage: from isolated nucleobases to nucleobase clusters.
abstract: A large number of studies are devoted to the investigation of the biomolecular ionization and fragmentation dynamics underlying biological radiation damage. Most of these studies have been based on gas-phase collisions with isolated DNA building blocks. The radiobiological significance of these studies is often questioned because of the lack of a chemical environment. To clarify this aspect, we studied interactions of keV ions with isolated nucleobases and with nucleobase clusters by means of coincidence time-of-flight spectrometry. Significant changes already show up in the molecular fragmentation patterns of very small clusters.
authors.affiliation: KVI Atomic Physics, Rijksuniversiteit Groningen, Zernikelaan 25, 9747AA Groningen, The Netherlands. tschlat@kvi.nl
authors.forename: Thomas
authors.initials: T
authors.lastname: Schlathölter
authors.forename: Fresia
authors.initials: F
authors.lastname: Alvarado
authors.forename: Sadia
authors.initials: S
authors.lastname: Bari
authors.forename: Aurelie
authors.initials: A
authors.lastname: Lecointre
authors.forename: Ronnie
authors.initials: R
authors.lastname: Hoekstra
authors.forename: Virgil
authors.initials: V
authors.lastname: Bernigaud
authors.forename: Bruno
authors.initials: B
authors.lastname: Manil
authors.forename: Jimmy
authors.initials: J
authors.lastname: Rangama
authors.forename: Bernd
authors.initials: B
authors.lastname: Huber
mesh_terms: D000225:Adenine / Q000737:chemistry; D001482:Base Composition; D001703:Biophysics / Q000379:methods; D002627:Chemistry, Physical / Q000379:methods; D004247:DNA / Q000737:chemistry*; D004583:Electrons; D006860:Hydrogen Bonding; D007477:Ions; D013058:Mass Spectrometry; D008968:Molecular Conformation; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D013053:Spectrophotometry; D013941:Thymine / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry
chemical_list: D007477:Ions; D011687:Purines; D011743:Pyrimidines; D014498:Uracil; D004247:DNA; D000225:Adenine; C030986:pyrimidine; D013941:Thymine