The expression of PRDI-BF1 beta isoform in multiple myeloma plasma cells.
The PRDM1 gene, a master regulator of plasma cells (PC), can generate two transcription factor isoforms: PRDI-BF1alpha and PRDI-BF1beta. The present study shows that purified human normal PC have a significantly lower levels of PRDI-BF1beta expression than that in tumoral PC isolated from multiple myeloma (MM) (0.06+/-0.01 and 0.25+/-0.05, respectively; p<0.001). The role of this finding in MM is discussed.
Ocaña
Esther
E
González-García
Inés
I
Gutiérrez
Norma C
NC
Mora-López
Francisco
F
Brieva
José A
JA
Campos-Caro
Antonio
A
D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000378:metabolism*; D010950:Plasma Cells / Q000378:metabolism*; D000074462:Positive Regulatory Domain I-Binding Factor 1; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D012097:Repressor Proteins / Q000096:biosynthesis* / Q000235:genetics; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
D020033:Protein Isoforms; D012097:Repressor Proteins; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1