Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction.
OBJECTIVE
We sought to investigate the association between increased levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, and total plasma homocysteinemia (tHcy) in patients with acute myocardial infarction (AMI).


METHODS
In 138 patients hospitalized for AMI <24 h on admission, serum levels of ADMA, its symmetric stereoisomer (SDMA) and tHcy were measured.


RESULTS
ADMA was positively associated with SDMA (p<0.001) and tHcy (p=0.03) but not with estimated glomerular filtration rates (eGFR, p=0.96), while tHcy strongly correlated with eGFR (p=0.002) and SDMA (p<0.001). By multiple linear regression, SDMA but not ADMA was independently associated with tHcy (p=0.005).


CONCLUSIONS
Our findings suggest that, in AMI patients, hyperhomocysteinemia is indirectly related to ADMA levels via renal function. Moreover, ADMA level was independent of traditional cardiovascular risk factors in AMI patients. Interestingly, our findings suggest that SDMA could be a good risk indicator for cardiovascular disease in AMI patients.
Korandji
Claudia
C
Laboratory of Experimental Cardiovascular Pathophysiology and Pharmacology, IFR100, Faculties of Medecine and Pharmacy, University of Burgundy, Dijon, France.
Zeller
Marianne
M
Guilland
Jean-Claude
JC
Vergely
Catherine
C
Sicard
Pierre
P
Duvillard
Laurence
L
Gambert
Philippe
P
Moreau
Daniel
D
Cottin
Yves
Y
Rochette
Luc
L
D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D012044:Regression Analysis; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013237:Stereoisomerism
D006710:Homocysteine; C018524:N,N-dimethylarginine; D001120:Arginine