Effects of post low-dose X-ray irradiation on carbon tetrachloride-induced acatalasemic mice liver damage.
The catalase activities in the blood and organs of the acatalasemic (C3H/AnLCsb-Csb) mouse of the C3H strain are lower than those of the normal (C3H/AnLCSa-Csa) mouse. We examined the effects of post low-dose (0.5 Gy) X-ray irradiation which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in acatalasemic or normal mice. As a result, the 0.5 Gy irradiation after carbon tetrachloride administration decreased the glutamic oxaloacetic and glutamic pyruvic transaminase activity in the acatalasemic mouse blood to a level similar to that of the acatalasemic mouse blood not treated with carbon tetrachloride; this is in contrast to a high-dose (15 Gy) irradiation. In the same manner, pathological disorder was improved by 0.5 Gy irradiation. The fat degeneration in normal mice was quickly reduced, in contrast to acatalasemic mice. These findings suggest that low-dose irradiation after carbon tetrachloride administration accelerates the rate of recovery and that catalase plays an important role in the recovery from hepatopathy induced by carbon tetrachloride, in contrast to high-dose irradiation.
Kataoka
Takahiro
T
Okayama University Medical School, Japan.
Nomura
Takaharu
T
Wang
Da-Hong
DH
Taguchi
Takehito
T
Yamaoka
Kiyonori
K
D020642:Acatalasia / Q000139:chemically induced / Q000473:pathology*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000150:complications*; D002374:Catalase / Q000097:blood; D004307:Dose-Response Relationship, Radiation; D008099:Liver / Q000473:pathology / Q000528:radiation effects*; D051379:Mice; D008809:Mice, Inbred C3H; D018384:Oxidative Stress; D011829:Radiation Dosage; D014965:X-Rays
D002374:Catalase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase