Role of nitric oxide in the regulation of T cell functions.
There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proliferation and the potential effect of nitric oxide on regulatory T (Treg) cells. On the basis of the results the authors propose that nitric oxide represents an additional signal for the induction of T cell subset response, contributing to the increasingly complex network of immune regulation essential for health and disease.
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Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, UK. F.Liew@clinmed.gla.ac.uk.
Cai
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Liew
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D002454:Cell Differentiation / Q000276:immunology; D006152:Cyclic GMP / Q000276:immunology; D006801:Humans; D009569:Nitric Oxide / Q000276:immunology*; D053707:Receptors, Interleukin-12 / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
C508439:IL12RB2 protein, human; D053707:Receptors, Interleukin-12; D009569:Nitric Oxide; D006152:Cyclic GMP