The effects of meperidine in the pulmonary vascular bed of the cat.
OBJECTIVE
The purpose of this study was to test the hypothesis that meperidine induces a dilator response in the feline pulmonary vascular bed, and to identify receptors involved in the mediation or modulation of these effects.


METHODS
Prospective vehicle controlled study.


METHODS
University research laboratory.


METHODS
Intact chest preparation; adult mongrel cats.


METHODS
In separate experiments, the effects of diphenydramine (histamine H(1)-receptor antagonist), glibenclamide (adenosine triphosphate-sensitive K+ channel blocker), L-N(5)-(1-Iminoethyl) ornithine hydrochloride (L-NIO) (nitric oxide synthase inhibitor), naloxone (opioid receptor antagonist), and nimesulide (selective cyclooxygenase-2 inhibitor) were investigated on pulmonary arterial responses to meperidine and other agonists in the feline lung bed.


RESULTS
The systemic pressure and lobar arterial perfusion pressure were continuously monitored, electronically averaged, and permanently recorded. Under elevated tone conditions in the isolated left lower lobe vascular bed of the cat, meperidine induced a dose-dependent vasodilator response that was not significantly altered after administration of glibenclamide, L-NIO, and nimesulide. Responses to meperidine were significantly attenuated after the administration of diphenydramine and naloxone.


CONCLUSIONS
The results suggest that meperidine has potent vasodilator activity in the feline pulmonary vascular bed, and these responses are mediated or modulated, in part, by opioid and histamine receptor-sensitive pathways.
Kaye
Alan D
AD
Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. akaye@lsuhsc.edu <akaye@lsuhsc.edu>
Hoover
Jason M
JM
Baber
Syed R
SR
Ibrahim
Ikhlass N
IN
Phelps
James
J
Fields
Aaron
A
Baluch
Amir
A
Huffman
Shane
S
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D005260:Female; D005500:Follow-Up Studies; D006976:Hypertension, Pulmonary / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D011379:Prognosis; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000187:drug effects* / Q000502:physiology; D011667:Pulmonary Veins / Q000187:drug effects* / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D000701:Analgesics, Opioid; D008614:Meperidine