title: An Asian patient with intraocular lymphoma treated by intravitreal methotrexate.
abstract: BACKGROUND
  To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma.
  
  
  METHODS
  A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma.
  
  
  METHODS
  The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up.
  
  
  CONCLUSIONS
  Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma.
authors.affiliation: Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan.
authors.forename: Jia-Kang
authors.initials: JK
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chung-May
authors.initials: CM
authors.lastname: Yang
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. cpilin@ms7.hinet.net.
authors.forename: Chang-Ping
authors.initials: CP
authors.lastname: Lin
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Yin-Dong
authors.initials: YD
authors.lastname: Shan
authors.affiliation: Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan.
authors.forename: Andy Y
authors.initials: AY
authors.lastname: Lo
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Hwei-Fang
authors.initials: HF
authors.lastname: Tien
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007267:Injections; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D013624:Taiwan; D014822:Vitreous Body
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate