[Properties of the Ebola virus glycoprotein].
In central and west Africa, Ebola virus, a member of the filovirus group, has produced sporadic outbreaks of lethal disease. This virus causes hemorrhagic fever in humans and nonhuman primates, resulting in mortality rates of up to 90%. Although there are no satisfactory biologic explanations for this extreme virulence, it has been suggested that functions of the envelope glycoprotein are likely to play important roles in the pathogenicity of Ebola virus.
Takada
Ayato
A
Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Kita-18, Nishi-9, Kita-ku, Sapporo 060-0818, Japan. atakada@czc.hokudai.ac.jp
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000914:Antibodies, Viral; D029043:Ebolavirus / Q000472:pathogenicity*; D000939:Epitopes; D019142:Hemorrhagic Fever, Ebola / Q000628:therapy / Q000821:virology*; D006801:Humans; D007116:Immunization, Passive; D037181:Lectins, C-Type / Q000502:physiology; D009500:Neutralization Tests; D009928:Organ Specificity; D014760:Viral Fusion Proteins / Q000276:immunology / Q000502:physiology*; D014774:Virulence
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000939:Epitopes; D037181:Lectins, C-Type; D014760:Viral Fusion Proteins