title: Molecular genetics of pediatric central nervous system tumors.
abstract: Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to treatment stratification and improved outcome prediction. All new protocols involving treatments for brain tumors in children include studies of biomarkers and biologic correlates as a means to identify new targets for therapeutics and possible intervention strategies.
authors.affiliation: Department of Neurology, Children's Hospital Boston, Boston, MA 02115, USA. Nicole.ullrich@childrens.harvard.edu
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: Ullrich
authors.forename: Scott L
authors.initials: SL
authors.lastname: Pomeroy
mesh_terms: D001254:Astrocytoma / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics; D016543:Central Nervous System Neoplasms / Q000235:genetics*; D002648:Child; D016545:Choroid Plexus Neoplasms / Q000145:classification / Q000235:genetics; D015195:Drug Design; D004806:Ependymoma / Q000145:classification / Q000235:genetics; D005910:Glioma / Q000235:genetics; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics; D008967:Molecular Biology / Q000379:methods; D018335:Rhabdoid Tumor / Q000145:classification / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor