title: Characterization of the disposition of lutein after i.v. administration to rats.
abstract: Lutein is a carotenoid that has antioxidant effects. Although lutein has received much attention recently due to its antioxidant activities, little information about the pharmacokinetic properties of lutein is available. The disposition of lutein after i.v. administration has not been investigated because lutein is now used as a supplement. The present study was undertaken to acquire additional data on the disposition of lutein after i.v. administration. After i.v. administration, lutein is preferentially distributed to the liver, spleen and lung. Intravenous administration of lutein may provide effective antioxidant activities in these tissues, not only the eye. The results of this study should provide valuable data for drug development.
authors.affiliation: Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, sapporo, Japan.
authors.forename: Shirou
authors.initials: S
authors.lastname: Itagaki
authors.forename: Wakako
authors.initials: W
authors.lastname: Ogura
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sato
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Noda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirano
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizuno
authors.forename: Ken
authors.initials: K
authors.lastname: Iseki
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D014975:Lutein / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D000975:Antioxidants; D014975:Lutein