title: Surgery for local recurrence of rectal cancer.
abstract: OBJECTIVE
  Despite improvement in management of primary rectal cancer, 2.6-32% of patients develop local recurrence. A proportion of these patients can be amenable to salvage surgery. The present article reviews the evidence for and against the surgical management for local recurrence of rectal cancer, the role of adjuvant and intraoperative radiotherapy (IORT), and evaluates short and long-term outcomes.
  
  
  METHODS
  A literature search was performed using Medline, Embase, Ovid and Cochrane database for studies between 1980 and 2005 assessing surgical management of local recurrence of rectal cancer and the evidence was critically evaluated.
  
  
  RESULTS
  Nearly 50% of rectal cancer recurrences are local and are therefore potentially amenable to curative resection. Preoperative imaging is important for appropriate selection of patients for surgery and preoperative adjuvant therapy is essential. Five-year survival following resection ranges from 18% to 58% with 5-year survival following complete resection of over 35% though morbidity ranges from 21% to 82%. Neoadjuvant radiotherapy is beneficial and IORT may have a contributory role in treatment. Aggressive surgical treatment favourably affects quality of life and is cost effective. Surgery for local recurrence can result in significant long-term survival with acceptable morbidity and improved quality of life in appropriately selected patients. Assessment in a specialist centre familiar with these techniques is essential.
authors.affiliation: Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. Alexander.Heriot@petermac.org
authors.forename: A G
authors.initials: AG
authors.lastname: Heriot
authors.forename: P P
authors.initials: PP
authors.lastname: Tekkis
authors.forename: A
authors.initials: A
authors.lastname: Darzi
authors.forename: J
authors.initials: J
authors.lastname: Mackay
mesh_terms: D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D006801:Humans; D007432:Intraoperative Period; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000601:surgery*; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D015996:Survival Rate