Effect of topical vitamin D analogue on in vivo contact sensitization.
BACKGROUND
The immunomodulatory role of vitamin D and its analogues has been demonstrated in vitro and in vivo using animal models. We evaluated the effect of a vitamin D analogue, calcipotriene, in vivo on human subjects using a contact hypersensitivity model.


METHODS
Subjects were pretreated with topical calcipotriene, simulated solar radiation, or both on buttock skin. They were then sensitized and challenged using the contact allergen dinitrochlorobenzene. Immune response was measured by change in skinfold thickness before vs after elicitation across the challenge sites.


CONCLUSIONS
Calcipotriene-treated individuals demonstrated 64% immunosuppression compared with untreated controls. This is equivalent to the immunosuppression induced by UV exposure.
Hanneman
Kaija K
KK
Department of Dermatology, Skin Study Center, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, Ohio 44106, USA. kaija.hanneman@uhhs.com
Scull
Heather M
HM
Cooper
Kevin D
KD
Baron
Elma D
ED
D000279:Administration, Cutaneous; D000485:Allergens; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D017449:Dermatitis, Allergic Contact / Q000276:immunology*; D004137:Dinitrochlorobenzene; D006801:Humans; D007801:Langerhans Cells / Q000187:drug effects; D010328:Patch Tests; D013472:Sunlight
D000485:Allergens; D004137:Dinitrochlorobenzene; C055085:calcipotriene; D002117:Calcitriol