[Concentration of interleukine-8 in tears in patients with cystic fibrosis].
OBJECTIVE
To evaluate IL-8 concentration in tears fluid in cystic fibrosis patients.


METHODS
Tears samples were collected from 18 CF Patients and 18 normal controls. Cytokine level was determined by ELISA.


RESULTS
A significant increase of IL-8 concentration in tears fluid was found in CF patients compared with controls.


CONCLUSIONS
Increase IL-8 concentration in tears fluid in CF patients suggests a role of immunologic processes in the pathogenesis of the ocular changes, and may be a marker of the inflammatory status in ocular surface in cystic fibrosis.
Mrugacz
Małgorzata
M
Kliniki Okulistyki Dzieciecej, Akademii Medycznej w Białymstoku.
Zelazowska
Beata
B
Bakunowicz-Lazarczyk
Alina
A
Minarowska
Alina
A
Wysocka
Jolanta
J
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002648:Child; D003550:Cystic Fibrosis / Q000276:immunology / Q000378:metabolism*; D005123:Eye / Q000276:immunology; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis*; D008297:Male; D012016:Reference Values; D013666:Tears / Q000737:chemistry*
D015415:Biomarkers; D016209:Interleukin-8