Dopaminergic control of sleep-wake states.
Dopamine depletion is involved in the pathophysiology of Parkinson's disease, whereas hyperdopaminergia may play a fundamental role in generating endophenotypes associated with schizophrenia. Sleep disturbances are known to occur in both schizophrenia and Parkinson's disease, suggesting that dopamine plays a role in regulating the sleep-wake cycle. Here, we show that novelty-exposed hyperdopaminergic mice enter a novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological activity observed during rapid-eye-movement (REM) sleep. Treatment with haloperidol, a D2 dopamine receptor antagonist, reduces this abnormal intrusion of REM-like activity during wakefulness. Conversely, mice acutely depleted of dopamine enter a different novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological activity observed during slow-wave sleep (SWS). This dopamine-depleted state is marked by an apparent suppression of SWS and a complete suppression of REM sleep. Treatment with D2 (but not D1) dopamine receptor agonists recovers REM sleep in these mice. Altogether, these results indicate that dopamine regulates the generation of sleep-wake states. We propose that psychosis and the sleep disturbances experienced by Parkinsonian patients result from dopamine-mediated disturbances of REM sleep.
Dzirasa
Kafui
K
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Ribeiro
Sidarta
S
Costa
Rui
R
Santos
Lucas M
LM
Lin
Shih-Chieh
SC
Grosmark
Andres
A
Sotnikova
Tatyana D
TD
Gainetdinov
Raul R
RR
Caron
Marc G
MG
Nicolelis
Miguel A L
MA
D000818:Animals; D050483:Dopamine Plasma Membrane Transport Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology; D012894:Sleep Stages / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
D050483:Dopamine Plasma Membrane Transport Proteins