Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI.
The active ingredients of 'golden root' of Scutellaria baicalensis GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin. With the objective of overcoming their poor solubility and to investigate their structure and activity relationships, baicaleinyl 7-O-sulfate was prepared, and extensive comparative antioxidative and anti-inflammatory tests were conducted. All the polyhydroxyflavonoids exhibited significant antioxidative and free-radical scavenging activities. In respect of their nitric oxide (NO) inhibition, wogonin was superior to all the other flavonoids, while oroxylin A was most potent in the inhibition of lipid peroxidation. Wogonin proved to be the most potent (82.9% inhibition, p<0.05) in its anti-inflammatory activity against carrageenan-induced rat hind paw edema. There was a correlation between the in-vivo anti-inflammatory activity and the in-vitro antioxidative activities.
Huang
Wen-Hsin
WH
School of Pharmacy, National Defense Medical Center, Taiwan. wenhsin@mail.ndmctsgh.edu.tw
Lee
An-Rong
AR
Yang
Ching-Huey
CH
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal; D004487:Edema / Q000188:drug therapy; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D016166:Free Radical Scavengers; D015227:Lipid Peroxidation / Q000187:drug effects; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D008517:Phytotherapy; D051381:Rats; D031364:Scutellaria baicalensis / Q000737:chemistry*; D012995:Solubility; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; D016166:Free Radical Scavengers; D009569:Nitric Oxide; C006680:baicalein; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one; C085514:wogonin