Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation.
Post-retrieval interference with a memory has uncovered a phenomenon known to the field as reconsolidation. In this article, we will review the specific molecular mechanisms that have been implicated in reconsolidation. As a result of numerous studies over the past five years, it can now be said with a fair amount of certainty that reconsolidation is not a recapitulation of the mechanisms underlying consolidation, despite what the term "reconsolidation" may suggest. Therefore, in addition to reviewing the known mechanisms of reconsolidation, we will propose that two experimental approaches involving the targeting of specific molecular mechanisms, and the study of these mechanisms during retrieval, may serve useful to the field as it is now able to advance beyond comparisons between consolidation and reconsolidation.
Miller
Courtney A
CA
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Sweatt
J David
JD
D000465:Algorithms; D000647:Amnesia / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology