Role of serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice.
This study examined the roles of presynaptic and postsynaptic serotonin type 1A receptors in fluvoxamine-induced inhibition of marble-burying behavior in mice. The effect of fluvoxamine was attenuated by the serotonin type 1A receptor antagonist WAY100635 at 1 mg/kg, while it was enhanced by the antagonist at 0.1 mg/kg. Fluvoxamine (30 mg/kg) and WAY100635 (0.1 and 1 mg/kg) did not affect spontaneous locomotor activity. These results suggest that the effect of fluvoxamine is mediated by postsynaptic serotonin type 1A receptors and it is enhanced by an inhibition of presynaptic serotonin type 1A receptors.
Harasawa
Toshiya
T
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical, Osaka University, Osaka, Japan.
Ago
Yukio
Y
Itoh
Soichi
S
Baba
Akemichi
A
Matsuda
Toshio
T
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000187:drug effects*; D016666:Fluvoxamine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects*; D017661:Receptors, Presynaptic / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D010879:Piperazines; D011725:Pyridines; D017661:Receptors, Presynaptic; D012702:Serotonin Antagonists; D044282:Receptor, Serotonin, 5-HT1A; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D016666:Fluvoxamine