Antimalarial activity of sesquiterpene lactones from Vernonia cinerea.
Two new sesquiterpene lactones, vernolides C and D as well as six known ones were isolated from the dichloromethane fraction of an aqueous extract from Vernonia cinerea. Their structures were elucidated by spectroscopic methods. Among the known sesquiterpene lactones, three of them were described in this plant for the first time. In vitro antiplasmodial evaluation showed that the three major compounds 1, 7 and 8 were active against chloroquine resistant Plasmodium falciparum strain (W2) with IC(50) 3.9, 3.7 and 3.5 microM, respectively.
Chea
Aun
A
Laboratoire de Pharmacognosie, Faculté de Pharmacie, Marseille, France.
Hout
Sotheara
S
Long
Christophe
C
Marcourt
Laurence
L
Faure
Robert
R
Azas
Nadine
N
Elias
Riad
R
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D066298:In Vitro Techniques; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D012015:Reference Standards; D012680:Sensitivity and Specificity; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D035741:Vernonia / Q000737:chemistry*
D000962:Antimalarials; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; C516231:vernolide C; C516232:vernolide D; D002738:Chloroquine