Toxicological mechanisms of Aconitum alkaloids.
The toxic effects of Aconitum alkaloids are known to affect mainly the central nervous system, heart and muscle tissues. Their toxicological mechanisms may involve interaction with voltage-dependent Na+ channels, modulation of neurotransmitter release and related receptors, promotion of lipid peroxidation and induction of cell apoptosis in heart, liver or other organs. Of them, the mechanism of interaction with voltage-dependent Na+ channels is quite well known, but the other factors are still unclear, and need to be further studied. This review focuses on the toxicological mechanisms of Aconitum alkaloids.
Fu
M
M
Medicine School and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China.
Wu
M
M
Qiao
Y
Y
Wang
Z
Z
D031841:Aconitum / Q000633:toxicity*; D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D009498:Neurotoxins / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D011955:Receptors, Drug / Q000187:drug effects; D015222:Sodium Channels / Q000187:drug effects
D000470:Alkaloids; D009498:Neurotoxins; D018377:Neurotransmitter Agents; D011955:Receptors, Drug; D015222:Sodium Channels