title: Synthesis of diverse analogues of Oenostacin and their antibacterial activities.
abstract: Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC(50) ranging from 0.49 to 0.67 microM as compared to Oenostacin (EC(50)=0.12 microM).
authors.affiliation: Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, Kukrail Picnic Spot Road, Lucknow 226 015, India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Srivastava
authors.forename: Mahendra P
authors.initials: MP
authors.lastname: Darokar
authors.forename: Atiya
authors.initials: A
authors.lastname: Fatima
authors.forename: J K
authors.initials: JK
authors.lastname: Kumar
authors.forename: Chinmay
authors.initials: C
authors.lastname: Chowdhury
authors.forename: Hari Om
authors.initials: HO
authors.lastname: Saxena
authors.forename: Gaurav R
authors.initials: GR
authors.lastname: Dwivedi
authors.forename: Kunal
authors.initials: K
authors.lastname: Shrivastava
authors.forename: Vivek
authors.initials: V
authors.lastname: Gupta
authors.forename: S K
authors.initials: SK
authors.lastname: Chattopadhyay
authors.forename: Suaib
authors.initials: S
authors.lastname: Luqman
authors.forename: M M
authors.initials: MM
authors.lastname: Gupta
authors.forename: Arvind S
authors.initials: AS
authors.lastname: Negi
authors.forename: Suman P S
authors.initials: SP
authors.lastname: Khanuja
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D004305:Dose-Response Relationship, Drug; D062385:Hydroxybenzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D062385:Hydroxybenzoates; C517130:oenostacin