title: Primary germinoma arising from the midbrain.
abstract: A 29-year-old man presented with diplopia, dysarthria, anisocoria, oculomotor nerve paralysis, abducens nerve paralysis, right facial palsy, and spastic hemiparetic gait. Magnetic resonance imaging (MRI) showed a homogenously enhanced mass in the midbrain. MRI-guided stereotactic biopsy was performed, and the histologic diagnosis was pure germinoma. The tumor disappeared after chemotherapy and radiotherapy. Germinoma should be included in the differential diagnosis of midbrain lesions in young adults. MRI-guided stereotactic biopsy provided a helpful diagnostic clue in a patient with a midbrain lesion.
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Koizumi
authors.forename: H
authors.initials: H
authors.lastname: Oka
authors.forename: S
authors.initials: S
authors.lastname: Utsuki
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Tanizaki
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Iizuka
authors.forename: F
authors.initials: F
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Fujii
mesh_terms: D000328:Adult; D015875:Anisocoria / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D020295:Brain Stem Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D004172:Diplopia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D004358:Drug Therapy; D018237:Germinoma / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology* / Q000503:physiopathology; D038361:Neuronavigation; D015840:Oculomotor Nerve Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D011878:Radiotherapy; D016896:Treatment Outcome