title: Rigid gas-permeable contact lens base curve radius and transmissibility effects on corneal oxygen uptake.
abstract: OBJECTIVE
  The purpose of this study is to determine the effects of rigid gas-permeable contact lens thickness, base curve radius, and material permeability on corneal hypoxic stress.
  
  
  METHODS
  Corneal oxygen uptake rates were measured with a Clark-type polarographic electrode on the right eye of 10 human subjects for the normal open eye (air) and after 5 minutes of static wear of rigid contact lenses of four cornea-to-contact lens base curve fitting relationships: 0.2 mm steeper-than-K (STK), 0.1 mm STK, on K, and 0.1 mm flatter-than-K (FTK). There were also four materials (polymethylmethacrylate [Dk=0], lotifocon B [OP-2, Dk=15.9], lotifocon A [OP-3, Dk=30], lotifocon C [OP-6; Dk=60]) and three center thicknesses (0.14, 0.28, and 0.53 mm for the OP-6 lenses and 0.14 mm for all other materials) with all other parameters being constant. Each subject participated in two identical sessions. A repeated-measures analysis of variance was performed to compare the mean response across lens materials/thicknesses and the four curvature values.
  
  
  RESULTS
  Significant differences were found only for lens material/thickness (p<0.0001). Although OP-2 and OP-6 (0.53 mm) were manufactured to have the same Dk/t, post hoc comparisons showed that the oxygen uptake rate with OP-6 (0.53 mm) was significantly lower. The same is also true for OP-3 and OP-6 (0.28 mm), with OP-6 (0.28 mm) having a significantly lower oxygen uptake rate.
  
  
  CONCLUSIONS
  In contrast to past studies with PMMA, cornea-to-contact lens base curve fitting relationship, with the lens materials and designs studied here, did not affect corneal hypoxic stress, and thick, high Dk lenses resulted in less change in corneal response than did thin, lower Dk lenses of the same Dk/t. This is attributed to the lens reservoir effect that has been previously described.
authors.affiliation: The Ohio State University, College of Optometry, Columbus, Ohio 43210-1240, USA. fink.4@osu.edu
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Fink
authors.forename: G Lynn
authors.initials: GL
authors.lastname: Mitchell
authors.forename: Richard M
authors.initials: RM
authors.lastname: Hill
mesh_terms: D000328:Adult; D003261:Contact Lenses; D003315:Cornea / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D017736:Ion-Selective Electrodes; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010539:Permeability
chemical_list: D010100:Oxygen