Chemotherapy of leishmaniasis: recent advances in the treatment of visceral disease.
New lipid formulations of amphotericin B--AmBisome, Amphotec, and Abelcet--have dramatically decreased the toxicity associated with amphotericin B and have made this group of agents the treatment of choice for visceral leishmaniasis. An agent of a completely different chemical class, the aminoglycoside aminosidine, was 97% curative in India. This agent too may be used for visceral leishmaniasis.
Berman
J
J
Walter Reed Army Institute of Research, Washington DC 20307, USA. COL_Jonathan_Berman@WRSMTP-ccmail.Army.Mil