title: A commentary on neuronal degeneration and cell death in Guam ALS and PD: an evolutionary process of understanding.
abstract: The Twentieth Century witnessed tremendous advances in our understanding of neurodegenerative diseases. Not least among them were the contributions from hyperendemic foci of neurodegenerative disorders in isolated human groups worldwide, with the knowledge gained applicable to our understanding of related neurodegenerative diseases globally.
authors.affiliation: Laboratory of Biomedical Anthropology and Neurosciences, State University of New York at Binghamton, Binghamton, New York 13902-6000, USA. rgarruto@binghamton.edu
authors.forename: Ralph M
authors.initials: RM
authors.lastname: Garruto
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000235:genetics; D004781:Environmental Exposure / Q000009:adverse effects; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006141:Guam / Q000453:epidemiology; D006801:Humans; D028361:Mitochondrial Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009410:Nerve Degeneration / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D009498:Neurotoxins / Q000378:metabolism / Q000633:toxicity; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D009498:Neurotoxins