title: Evaluation of four different fecal tests for determination of cure after Helicobacter pylori treatment.
abstract: BACKGROUND
  Data evaluating the monoclonal tests for determination of cure after Helicobacter pylori treatment are scarce.
  
  
  OBJECTIVE
  This study was aimed to evaluate the usefulness of 4 stool tests-2 new RAPID monoclonal immunochromatographic tests (RAPID Hp StAR, DakoCytomation, Cambridge, UK and ImmunoCard STAT! HpSA, Meridian Diagnostics, Cincinnati, OH) a monoclonal EIA test (Amplified IDEIA Hp StAR, DakoCytomation, Cambridge, UK), and a polyclonal EIA test (Premier Platinum HpSA, Meridian Diagnostics, Cincinnati, OH)-to confirm cure of H. pylori infection after eradication treatment.
  
  
  METHODS
  Ninety-seven patients who underwent eradication treatment were included. Cure of H. pylori infection was determined using 2 consecutive reference tests. Fecal tests were performed according to the specifications of the manufacturer. Sensitivity, specificity, and positive and negative predictive values were calculated.
  
  
  RESULTS
  After H. pylori eradication, the RAPID Hp StAR test has a sensitivity of 73% for detecting persistent infection, a specificity of 96% to 98%, a positive predictive value of 73% to 80% and a negative predictive value of 96%. For ImmunoCard STAT! HpSA the corresponding values were 91%, 97%, 77%, and 99%, for Amplified IDEIA Hp StAR 73%, 97%, 73%, and 97%, and for Premier Platinum HpSA 91%, 79%, 35%, and 98%.
  
  
  CONCLUSIONS
  All tests except Premier Platinum HpSA were highly accurate confirming eradication after treatment.
authors.affiliation: Unitat de Malalties Digestives, Hospital de Sabadell, Institut Universitari Parc Taulí, Barcelona, Spain.
authors.forename: Mariela
authors.initials: M
authors.lastname: Quesada
authors.forename: Xavier
authors.initials: X
authors.lastname: Calvet
authors.forename: Angelina
authors.initials: A
authors.lastname: Dosal
authors.forename: Victoria
authors.initials: V
authors.lastname: Calvet
authors.forename: Isabel
authors.initials: I
authors.lastname: Sanfeliu
authors.forename: Laura
authors.initials: L
authors.lastname: Ribera
authors.forename: Theresa
authors.initials: T
authors.lastname: Choat
authors.forename: Barbara
authors.initials: B
authors.lastname: Fallowfield
authors.forename: Antònia
authors.initials: A
authors.lastname: Montserrat
authors.forename: Valentí
authors.initials: V
authors.lastname: Puig
authors.forename: Ferran
authors.initials: F
authors.lastname: Segura
mesh_terms: D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D011933:Reagent Kits, Diagnostic