[Discriminative ability, construct validity and sensitivity to change of the EQ-5D quality of life questionnaire in paranoid schizophrenia].
OBJECTIVE
To analyze the discriminative ability, construct validity and sensitivity to change of the EQ-5D in paranoid schizophrenia (ICD-10 F20.0).


METHODS
Data of 408 patients was analyzed in a longitudinal study by comparing EQ-5D with SF-36, CGI-S, PANSS, and GAF.


RESULTS
EQ-5D showed considerable discriminative ability in the patient sample when compared to a representative population sample. If a measure used for comparison and a EQ-5D dimension were theoretically corresponding, the measure's mean score differed significantly between EQ-5D answer levels, with largest effect sizes for SF-36 scales (0.34<|d|<1.76), but rather small values for CGI-S, PANSS and GAF (|d|<0.5). EQ-5D VAS (mean 61.3) and German EQ-5D index (mean 0.84) showed rather moderate correlations with most other scales (0.18<|r|<0.62). ROC-analysis indicated a very low sensitivity to change of EQ VAS and German EQ-5D index (0.50<AUC<0.58).


CONCLUSIONS
Although focusing on physical problems, the EQ-5D seems to have reasonable discriminative ability and construct validity, but very low sensitivity to change.
Konnopka
Alexander
A
Stiftungsprofessur für Gesundheitsökonomie, Universität Leipzig, Germany.
Günther
Oliver H
OH
Angermeyer
Matthias C
MC
König
Hans-Helmut
HH
D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000175:diagnosis / Q000523:psychology; D002908:Chronic Disease; D003863:Depression / Q000175:diagnosis / Q000523:psychology; D005260:Female; D005858:Germany; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000706:statistics & numerical data; D011788:Quality of Life / Q000523:psychology*; D012372:ROC Curve; D012016:Reference Values; D015203:Reproducibility of Results; D012563:Schizophrenia, Paranoid / Q000523:psychology / Q000534:rehabilitation*; D012917:Social Adjustment; D011795:Surveys and Questionnaires