Benign pulmonary metastasizing leiomvomatosis: case report and a review of the literature.
The authors report here on a case of a nearly asymptomatic 51-year-old Korean woman who was found to have diffuse, multiple nodules of the lungs on a routine chest radiograph. She had undergone hysterectomy 16 years previously for uterine myoma. An open lung biopsy revealed tumor that was composed of interlacing bundles of spindle cells with cigar shaped nucleus and eosinophilic myofibrils in the cytoplasm; consistent with multiple leiomyomas. The stains for SMA, desmin, MSA and Ki-67 were positive and the stain for c-kit was negative. The other stains for estrogen and progesterone receptor were positive. During the open lung biopsy procedure, all the nodules were excised. We report here on an interesting case of benign metastasizing leiomyoma (BML) in 51-year-old patient. To the best of our knowledge, this case showed the longest period of clinical progression in Korea. This is also one of a few cases in which curative excision was successfully performed.
Kwon
Young-Il
YI
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Kim
Tae-Hyung
TH
Sohn
Jang Won
JW
Yoon
Ho Joo
HJ
Shin
Dong Ho
DH
Park
Sung Soo
SS
D018450:Disease Progression; D005260:Female; D006801:Humans; D007044:Hysterectomy; D018231:Leiomyomatosis / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008875:Middle Aged; D010052:Ovariectomy; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery