title: Impaired verbal source monitoring in schizophrenia: an intermediate trait vulnerability marker?
abstract: Patients with schizophrenia, particularly those with positive symptoms show impaired verbal source monitoring. Specific cognitive deficits have been observed during both active and remission phases of the illness as well as in groups of unaffected first degree relatives of patients with schizophrenia. This type of schizophrenia vulnerability marker may precede the onset of frank psychotic symptoms and contribute to their developments. The aim of this study was first to determine if unaffected siblings were impaired in discriminate internal vs. external generated events when compared to their remitted schizophrenics relatives and healthy subjects. Performances of healthy subjects were then compared with results from previous studies with acute hallucinating patients, acute non-hallucinating patients and patients with resistant auditory verbal hallucinations. Compared with healthy subjects, unaffected siblings are impaired (effect size, ES=0.7), remitted or acute non-hallucinating patients are more impaired than siblings (ES=1.4); patients with verbal auditory hallucinations (acute or resistant) are even more impaired than non-hallucinating patients (ES=2.1). Our results suggest that a source monitoring deficit could be considered as an intermediate vulnerability marker of schizophrenia.
authors.affiliation: EA3092, University Lyon1, Service du Pr Daley, CH le Vinatier, IFR19, France. jerome.brunelin@ch-le-vinatier.fr
authors.forename: Jérôme
authors.initials: J
authors.lastname: Brunelin
authors.forename: Thierry
authors.initials: T
authors.lastname: d'Amato
authors.forename: Philippe
authors.initials: P
authors.lastname: Brun
authors.forename: Benoit
authors.initials: B
authors.lastname: Bediou
authors.forename: Lassad
authors.initials: L
authors.lastname: Kallel
authors.forename: Muriel
authors.initials: M
authors.lastname: Senn
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Poulet
authors.forename: Mohamed
authors.initials: M
authors.lastname: Saoud
mesh_terms: D000328:Adult; D001288:Attention; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006212:Hallucinations / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D007389:Internal-External Control; D008297:Male; D010641:Phenotype; D011936:Reality Testing; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics*; D012565:Schizophrenic Psychology; D035781:Siblings; D013017:Sound Localization; D013067:Speech Perception
chemical_list: D005819:Genetic Markers