A new model for translational regulation of specific mRNAs.
Recently, RNA helicase A (RHA) has been shown to facilitate translation of specific mRNAs by recognizing and binding to a complex structure at their 5' end known as the post-transcriptional control element. This implicates RHA, a member of the DEXD/H-box protein superfamily, in linking transcription and translation of a specific class of retroviral and cellular mRNAs. This exciting finding suggests a new mechanism for the regulation of the translation of specific transcripts.
Tettweiler
Gritta
G
Department of Biology and DBRI, McGill University, 1205 Avenue Dr. Penfield, Montréal, Québec H3A 1B1, Canada.
Lasko
Paul
P
D008957:Models, Genetic; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics*
D012333:RNA, Messenger