A simple method for detection of imprinting effects based on case-parents trios.
Using data from families in which marker genotypes are known for the father, the mother and the affected offspring, a simple statistic for testing for imprinting effects is developed. The statistic considers whether the expected number of families in which the father carries more copies of a particular marker allele than the mother is equal to the expected number of families in which the mother carries more copies of the allele than the father. The proposed parent-of-origin effects test statistic (POET) is shown to be normally distributed and can be employed to test for imprinting in situations where the marker locus need not be a disease susceptibility locus and where the female and male recombination fractions are sex-specific. A simulation study is conducted to characterize the power of the POET and other properties, and its results show that it is appropriate to employ the POET.
Zhou
J-Y
JY
Department of Statistics and Actuarial Science, The University of Hong Kong, Hong Kong, China.
Hu
Y-Q
YQ
Fung
W K
WK
D000465:Algorithms; D000483:Alleles; D003198:Computer Simulation; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D018392:Genomic Imprinting; D006801:Humans; D008297:Male; D015233:Models, Statistical; D010290:Parents; D019655:Quantitative Trait, Heritable