title: Autologous hematopoietic stem cell transplant with melphalan and thiotepa is safe and feasible in pediatric patients with low normalized glomerular filtration rate.
abstract: Normalized glomerular filtration rate (nGFR) <60 mL/min/1.73 m(2) often precludes hematopoietic stem cell transplant (HSCT) in pediatric patients. Three patients with nGFR < 60 mL/min/1.73 m(2) enrolled on an institutional phase I trial of HSCT preparative therapy for advanced and recurrent solid tumors with escalating melphalan, ranging from 135 to 180 mg/m(2), thiotepa (600 mg/m(2)), and vincristine (2 mg/m(2)). An additional patient with low nGFR was treated with the same preparative therapy. None of the patients developed acute renal failure, excess toxicities during HSCT or delayed engraftment. These cases demonstrate that it is feasible and safe to perform HSCT in pediatric patients with low nGFR using melphalan- and thiotepa-based preparative therapy.
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA. atermuhlen@chi.osu.edu
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Termuhlen
authors.forename: Alfred
authors.initials: A
authors.lastname: Grovas
authors.forename: Kathryn
authors.initials: K
authors.lastname: Klopfenstein
authors.forename: Robin
authors.initials: R
authors.lastname: Rosselet
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Gross
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000503:physiopathology / Q000628:therapy*; D008558:Melphalan / Q000627:therapeutic use*; D009447:Neuroblastoma / Q000503:physiopathology / Q000628:therapy*; D013852:Thiotepa / Q000627:therapeutic use*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000503:physiopathology / Q000628:therapy*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D013852:Thiotepa; D008558:Melphalan