The influence of obesity on short- and long-term graft and patient survival after renal transplantation.
To determine short- and long-term patient and graft survival in obese [body mass index (BMI) >or= 30 kg/m(2)] and nonobese (BMI < 30 kg/m(2)) renal transplant patients we retrospectively analyzed our national-database. Patients 18 years or older receiving a primary transplant after 1993 were included. A total of 1,871 patients were included in the nonobese group and 196 in the obese group. In the obese group there were significantly more females (52% vs. 38.6%, P < 0.01) and patients were significantly older [52 years (43-59) vs. 48 years (37-58); P < 0.05]. Patient survival and graft survival were significantly decreased in obese renal transplant recipients (1 and 5 year patient survival were respectively 94% vs. 97% and 81% vs. 89%, P < 0.01; 1 and 5 year graft survival were respectively 86% vs. 92% and 71% vs. 80%, P < 0.01). Initial BMI was an independent predictor for patient death and graft failure. This large retrospective study shows that both graft and patient survival are significantly lower in obese renal transplant recipients.
Aalten
Jeroen
J
Department of Nephrology, University Medical Center St Radboud, Nijmegen, The Netherlands. j.aalten@AIG.umcn.nl
Christiaans
Maarten H
MH
de Fijter
Hans
H
Hené
Ronald
R
van der Heijde
Jaap Homan
JH
Roodnat
Joke
J
Surachno
Janto
J
Hoitsma
Andries
A
D000328:Adult; D015992:Body Mass Index; D005260:Female; D006085:Graft Survival; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000628:therapy; D016030:Kidney Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012042:Registries; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome