title: Chemopreventive property of dietary ginger in rat urinary bladder chemical carcinogenesis.
abstract: The modifying potential of ginger on the development of preneoplasia and tumors in the male Wistar rat urinary bladder was investigated in a 36-week-long initiation-promotion assay for chemical carcinogenesis. Groups G1 to G3 were given 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in drinking water for 5 weeks and a 3% uracil meal for the subsequent 3 weeks. Groups G4 and G5 were treated with 3% uracil only for the same period. After these steps, groups G2, and G3 and G4 were fed for 26 weeks a ginger extract mixed at 0.5 and 1.0% in a basal diet, respectively. Thirty six weeks after the beginning of the experiment all rats were killed. The multiplicity of urothelial lesions (hyperplasia and neoplasia) was significantly lower (P = 0.013) in group G3 than in groups G1 and G2. The results suggest that 1.0% ginger meal exerts a protective effect on the post-initiation stage of rat chemically-induced urothelial carcinogenesis.
authors.affiliation: Department of Morphology, Institute of Biosciences, UNESP São Paulo State University, Botucatu, 18618-000 SP, Brazil.
authors.forename: Shadia Muhammad
authors.initials: SM
authors.lastname: Ihlaseh
authors.forename: Maria Luiza Cotrim
authors.initials: ML
authors.lastname: de Oliveira
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Teràn
authors.forename: João Lauro Viana
authors.initials: JL
authors.lastname: de Camargo
authors.forename: Luís Fernando
authors.initials: LF
authors.lastname: Barbisan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002085:Butylhydroxybutylnitrosamine; D049109:Cell Proliferation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D018890:Chemoprevention / Q000379:methods*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D020939:Zingiber officinale; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014498:Uracil; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
chemical_list: D010936:Plant Extracts; D002085:Butylhydroxybutylnitrosamine; D014498:Uracil