title: Protein P200 is dispensable for Mycoplasma pneumoniae hemadsorption but not gliding motility or colonization of differentiated bronchial epithelium.
abstract: Mycoplasma pneumoniae protein P200 was localized to the terminal organelle, which functions in cytadherence and gliding motility. The loss of P200 had no impact on binding to erythrocytes and A549 cells but resulted in impaired gliding motility and colonization of differentiated bronchial epithelium. Thus, gliding may be necessary to overcome mucociliary clearance.
authors.affiliation: Department of Microbiology, University of Georgia, Athens, GA 30602, USA.
authors.forename: Jarrat L
authors.initials: JL
authors.lastname: Jordan
authors.forename: How-Yi
authors.initials: HY
authors.lastname: Chang
authors.forename: Mitchell F
authors.initials: MF
authors.lastname: Balish
authors.forename: Lynley S
authors.initials: LS
authors.lastname: Holt
authors.forename: Stephanie R
authors.initials: SR
authors.lastname: Bose
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Hasselbring
authors.forename: Robert H
authors.initials: RH
authors.lastname: Waldo
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Krunkosky
authors.forename: Duncan C
authors.initials: DC
authors.lastname: Krause
mesh_terms: D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D015153:Blotting, Western; D001980:Bronchi / Q000276:immunology / Q000382:microbiology; D045744:Cell Line, Tumor; D005455:Fluorescent Antibody Technique; D006382:Hemadsorption / Q000276:immunology*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D046529:Microscopy, Electron, Transmission; D008969:Molecular Sequence Data; D009079:Mucociliary Clearance / Q000276:immunology; D009177:Mycoplasma pneumoniae / Q000472:pathogenicity* / Q000502:physiology / Q000648:ultrastructure; D016133:Polymerase Chain Reaction; D020545:Respiratory Mucosa / Q000276:immunology / Q000382:microbiology*; D017422:Sequence Analysis, DNA
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; C099985:P200 protein, Mycoplasma pneumoniae