title: Cytomegalovirus esophagitis as a treatable complication of systemic sclerosis.
abstract: We report the case of a 51-year-old woman with a connective tissue disease of 8 years duration. She had been taking corticosteroids at a dose of 1 mg/kg/day and azathioprine at a dose of 3 mg/kg/day for 1 month. Given the clinical suspicion of systemic sclerosis (limited form of scleroderma), she was studied according to a protocol including endoscopy to assess the degree to which the underlying disease had affected the gastrointestinal tract. Endoscopy revealed a asymptomatic severe esophagitis and a subsequent biopsy disclosed the presence of cytomegalovirus. Cytomegalovirus pneumonia was also detected. Both processes were successfully managed with intravenous ganciclovir (5 mg/kg/12 hr) for 21 days. This report is a case of cytomegalovirus involving the esophagus in association with systemic sclerosis in a patient immunosuppressed because of drugs that she had been taking. This complication can be asymptomatic and is amenable to treatment.
authors.affiliation: Department of Rheumatology, Clínica Puerta de Hierro, Madrid, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Contreras
authors.forename: C
authors.initials: C
authors.lastname: Salas
authors.forename: J L
authors.initials: JL
authors.lastname: Andreu
authors.forename: J
authors.initials: J
authors.lastname: Mulero