[The relationship between smoking behavior in young people and CYP2A6 gene polymorphisms, between them and personality traits assessed by NEO-FFI].
We performed a survey on nicotine dependence among young students. We examined the CYP2A6 gene polymorphism using PCR-RFLP. We examined the personality traits using NEO-FFI. Samples were taken from young students of which 87 were smokers and 142 were non-smokers and we tried to clarify the relationship between the nicotine metabolizing ability (CYP2A6), personality, and smoking behavior. As a result, the frequency of the CYP2A6*4C gene was significantly higher among non-smokers than smokers, and the Openness score by NEO-FFI was higher among smokers than non-smokers. We concluded that the CYP2A6*4C gene and the Openness personality trait may be a cause of smoking among the young smokers. Therefore, there is a possibility that smoking behavior in youths may be affected not only by the CYP2A6 gene but also by the Openness personality trait.
Waga
Chikako
C
Department of Neurophysiology, Graduate School of Environmental Health, Azabu University, 1-17-71 Huchinobe, Sagamihara, Kanagawa 229-8501, Japan.
Iwahashi
Kazuhiko
K
D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D065637:Cytochrome P-450 CYP2A6; D006899:Mixed Function Oxygenases / Q000235:genetics*; D010551:Personality; D011110:Polymorphism, Genetic; D012907:Smoking / Q000235:genetics* / Q000523:psychology*
D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; D065637:Cytochrome P-450 CYP2A6