title: In utero losartan withdrawal and subsequent development of fetal inferior vena cava thrombosis.
abstract: BACKGROUND
  Angiotensin receptor blockers are antihypertensive medications prescribed by a wide variety of physicians, especially for patients with coexistent diabetes mellitus. Angiotensin receptor blockers, as well as angiotensin-converting enzyme inhibitors, are contraindicated in pregnancy.
  
  
  METHODS
  We describe the reversal of losartan-induced oligohydramnios at 27 weeks of gestation with subsequent development of fetal thrombosis and possible mechanism of action for this extremely rare in utero complication.
  
  
  CONCLUSIONS
  This theory may help explain the fetal stillbirths in women taking this class of medications during the second and third trimester of pregnancy.
authors.affiliation: Section of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Jamie N
authors.initials: JN
authors.lastname: Bakkum
authors.forename: Brian C
authors.initials: BC
authors.lastname: Brost
authors.forename: Keith L
authors.initials: KL
authors.lastname: Johansen
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Johnston
authors.forename: William J
authors.initials: WJ
authors.lastname: Watson
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage*; D000075202:Contraindications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D005315:Fetal Diseases / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000150:complications; D019808:Losartan / Q000008:administration & dosage*; D008875:Middle Aged; D016104:Oligohydramnios / Q000139:chemically induced*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D013927:Thrombosis / Q000209:etiology*; D014682:Vena Cava, Inferior / Q000196:embryology*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D019808:Losartan