The role of SUMO in chromosome segregation.
Chromosome segregation is an essential feature of the eukaryotic cell cycle. Efficient chromosome segregation requires the co-ordination of several cellular processes; some of which involve gross rearrangements of the overall structure of the genetic material. Recent advances in the analysis of the role of SUMO (small ubiquitin-like modifier) and in the identification of SUMO-modified targets indicate that sumoylation is likely to have several key roles in regulating chromosome segregation This mini-review summarises the recently published data concerning the role of SUMO in the processes required for efficient chromosome segregation.
Watts
Felicity Z
FZ
Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, E Sussex, UK. f.z.watts@sussex.ac.uk
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D020223:Chromosome Painting; D020090:Chromosome Segregation / Q000502:physiology*; D006801:Humans; D046912:Multiprotein Complexes; D009154:Mutation; D025842:SUMO-1 Protein / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D008941:Spindle Apparatus
D018797:Cell Cycle Proteins; D046912:Multiprotein Complexes; C486627:SMC5 protein, S cerevisiae; C486631:SMC6 protein, S cerevisiae; D025842:SUMO-1 Protein; D029701:Saccharomyces cerevisiae Proteins