title: Hepatic histopathological findings in HIV patients at postmortem in Jos university teaching hospital, Nigeria.
abstract: Multi-organ involvement by opportunistic infections and neoplasms is the major cause of morbidity and mortality in people living with HIV/AIDS. We determined the spectrum/frequency of hepatic histopathological lesions in a prospective study of postmortem liver biopsies from 100 patients (50 females and 50 males, age range 18-55 years) who died from HIV/AIDS in Jos university teaching hospital, Nigeria. The majority of the patients, 65 (65%), had clinical tuberculosis. Granulomatous hepatitis, chronic hepatitis, non-specific reactive hepatitis (NSRH) and steatosis were the commonest hepatic histopathologic lesions occurring in 34, 20,15 and 12% of patients, respectively. Seven (7%) had normal histological features. This study shows that the liver is affected in HIV/AIDS as reported elsewhere in the world. Therefore, liver biopsy in HIV patients may be helpful in the management of these patients.
authors.affiliation: Department of Anatomic Pathology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria. ogechejoh@yahoo.com
authors.forename: Godwins O
authors.initials: GO
authors.lastname: Echejoh
authors.forename: Barnabas M
authors.initials: BM
authors.lastname: Mandong
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Tanko
authors.forename: Agabus N
authors.initials: AN
authors.lastname: Manasseh
authors.forename: Edith N
authors.initials: EN
authors.lastname: Okeke
authors.forename: Emmanuel I
authors.initials: EI
authors.lastname: Agaba
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001344:Autopsy; D001706:Biopsy; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000473:pathology; D006784:Hospitals, Teaching; D006785:Hospitals, University; D006801:Humans; D008099:Liver; D008107:Liver Diseases / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged