Surface modification of polymeric biomaterials: utilization of cyclodextrins for blood compatibility improvement.
A novel modified polymeric biomaterial surface using cyclodextrins (CDs) for improved blood compatibility was studied. Plasticized poly(vinyl chloride) (PVC-P) was selected for modification and polyethylene was used as a reference material. The modification was achieved by polymer blending. Fibrinogen and albumin adsorption were utilized as indices for the assessment of the blood compatibility. Surface characterization confirmed that CDs were able to accumulate at the PVC surface and alter the surface properties. The combination of other hydrophilic polymers such as poly(ethylene oxide) (PEO) and PEO/poly(propylene oxide) (PPO) copolymers, such as Pluronic F68 (F68), with CDs were also investigated. These modified materials have a remarkable protein-resistant surface. The combination of B-cyclodextrin (B-CD)/PEO and B-CD/F68 in certain feeding ratio are synergistic in producing enhanced blood compatibility.
Zhao
Xiaobin
X
Bioengineering Unit, University of Strathclyde, Glasgow G4 0NW, United Kingdom. x.zhao@novathera.com
Courtney
James M
JM
D000327:Adsorption; D000418:Albumins / Q000378:metabolism; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry*; D001798:Blood Proteins / Q000378:metabolism*; D003505:Cyclodextrins / Q000009:adverse effects*; D005340:Fibrinogen / Q000378:metabolism; D020442:Poloxamer; D011092:Polyethylene Glycols; D011108:Polymers / Q000009:adverse effects / Q000737:chemistry*; D011143:Polyvinyl Chloride; D011409:Propylene Glycols; D013499:Surface Properties
D000418:Albumins; D001672:Biocompatible Materials; D001798:Blood Proteins; D003505:Cyclodextrins; D011108:Polymers; D011409:Propylene Glycols; D020442:Poloxamer; C012504:polypropylene glycol; D011092:Polyethylene Glycols; D005340:Fibrinogen; D011143:Polyvinyl Chloride