title: Validation of the asthma impact survey, a brief asthma-specific quality of life tool.
abstract: BACKGROUND
  The Asthma Impact Survey (AIS-6) is a new six question asthma outcome tool for which information on validity has not been published.
  
  
  OBJECTIVE
  To provide validation for the AIS-6 as a brief asthma-specific quality of life tool.
  
  
  METHODS
  Surveys were sent to a random sample of members of a large managed care organization who were at least 35 years of age and in the two-year period preceding the survey had either (1) at least one documented asthma-related medical encounter, or (2) at least a 6 months supply of asthma medication dispensed. In addition to the AIS-6, the survey included a validated quality of life tool [the mini-Asthma Quality of Life Questionnaire (AQLQ)]; a validated asthma control questionnaire [the Asthma Therapy Assessment Questionnaire (ATAQ)]; a validated symptom severity scale (AOMS); and information regarding demographics, co-morbidities, asthma severity, and asthma management. The results of the AIS-6 were compared to the results of the other tools by means of correlation and factor analysis. Independent predictors of AIS-6 and AQLQ scores were determined by multiple stepwise linear regression analyses.
  
  
  RESULTS
  AIS-6 scores were significantly related to female sex, educational level, income, smoking, body mass index (BMI), COPD, steroid use, and hospitalization history in bivariate analyses. The AIS-6 score significantly correlated (r = - 0.84, p < 0.0001) with the AQLQ total score and loaded on the three factors (activity, symptoms, and concern/bother) reflected by the survey information and on which the AQLQ also loaded. Significant but somewhat smaller correlations were found between the AIS-6 and the ATAQ (r = 0.70, p < 0.0001) and the AOMS (r = 0.55, p < 0.0001). Independent predictors were the same for the AIS-6 and AQLQ and included oral steroid use, COPD history, BMI, female sex, educational level, and hospitalization in the past year.
  
  
  CONCLUSIONS
  These data support the validity of the short six-question AIS-6 as an asthma-specific quality of life tool.
authors.affiliation: Department of Allergy, Kaiser Permanente Medical Center, San Diego, CA 92111, USA. michael.x.schatz@kp.org
authors.forename: Michael
authors.initials: M
authors.lastname: Schatz
authors.forename: David
authors.initials: D
authors.lastname: Mosen
authors.forename: Mark
authors.initials: M
authors.lastname: Kosinski
authors.forename: William M
authors.initials: WM
authors.lastname: Vollmer
authors.forename: Elizabeth
authors.initials: E
authors.lastname: O'Connor
authors.forename: E Francis
authors.initials: EF
authors.lastname: Cook
authors.forename: Robert S
authors.initials: RS
authors.lastname: Zeiger
mesh_terms: D000328:Adult; D001249:Asthma / Q000523:psychology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012649:Self Concept; D011795:Surveys and Questionnaires; D014481:United States