title: A biocompatible method of decorporation: bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood.
abstract: We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.
authors.affiliation: Departments of Chemistry and Physics, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
authors.forename: Jinhao
authors.initials: J
authors.lastname: Gao
authors.forename: Keming
authors.initials: K
authors.lastname: Xu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Gu
authors.forename: Bei
authors.initials: B
authors.lastname: Zhang
authors.forename: Xixiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D004164:Diphosphonates / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013050:Spectrometry, Fluorescence; D014501:Uranium / Q000097:blood / Q000302:isolation & purification*
chemical_list: D001672:Biocompatible Materials; D004164:Diphosphonates; D014501:Uranium; D052203:Ferrosoferric Oxide