[The functional relevance of Arg16Gly and Gln27Glu-beta2-adrenoreceptor polymorphism in patients with asthma and allergic rhinitis].
The objective of the present study was to investigate the effect of beta2-adrenoreceptor polymorphisms Arg16Gly and Gln27Glu as well as their relationship to the pulmonary function parameters, and the clinical presentation in patients with asthma and allergic rhinitis. Investigated polymorphisms were in linkage disequilibrium, therefore their effects should be evaluated collectively. Although no significant association could be found with the presence of asthma or allergic rhinitis in studied population, polymorphisms of beta2-adrenoreceptor can influence pulmonary function in these patients. These effects significantly differ between men and women, possibly indicating the effect of sex hormones on genetic regulation of pulmonary function.
Cichy
Malgorzata
M
Katedra i Klinika Chorób Wewnetrznych i Medycyny Wsi, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków.
Adamek-Guzik
Teresa
T
Uracz
Danuta
D
Uracz
Wojciech
W
Czerniawska-Mysik
Grazyna
G
Korbut
Ryszard
R
Guzik
Tomasz J
TJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001120:Arginine / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D018698:Glutamic Acid / Q000235:genetics; D005973:Glutamine / Q000235:genetics; D005998:Glycine / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012129:Respiratory Function Tests; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics*; D017678:Sex Distribution
D018343:Receptors, Adrenergic, beta-2; D005973:Glutamine; D018698:Glutamic Acid; D001120:Arginine; D005998:Glycine