title: Intrathecal anesthesia.
abstract: OBJECTIVE
  Development of new drugs and special techniques, as well as changes in health care organization have markedly influenced the use of spinal block and its indications. The present review overviews recent developments in local anesthetic drugs, side effects and special techniques for intrathecal anesthesia.
  
  
  RESULTS
  Severe complications after spinal anesthesia are acceptably rare. The cardiovascular effects associated with sympathetic block are more frequent but may successfully be treated with volume expansion and administration of vasoactive drugs while the multimodal approach to prevention of such side effects can also reduce the incidence. Based on recent magnetic resonance imaging studies the volume of cerebrospinal fluid at the lumbosacral level is the main determinant of the effects produced by intrathecal injection of local anesthetic solutions. Unfortunately, it is not possible to estimate the volume of cerebrospinal fluid at the lumbosacral region in clinical practice, but it is clear that the total dose of local anesthetic injected into the subarachnoid space is the primary determinant of both therapeutic and unwanted effects of spinal anesthesia. There is overwhelming evidence of the potential risk for neurological dysfunction associated with spinal lidocaine. This evidence is even more relevant in outpatients, in whom lidocaine is primarily indicated. On the other hand, several studies have demonstrated the efficacy and safety of using small doses of long-acting agents, such as bupivacaine or ropivacaine, to produce a short spinal block. The addition of small doses of opioids further helps to minimize the dose of local anesthetic solution required, without affecting the recovery profile from spinal block. The extensive use of pencil-point designs for spinal needles, and the availability of needles of very small size have allowed a significant reduction in the incidence of postdural puncture headache.
  
  
  CONCLUSIONS
  The changes in health care organization observed during the past few years have forced us to change the indications for and clinical uses of intrathecal anesthesia techniques in accordance with the changing needs of surgery. The development of new drugs and special techniques for spinal anesthesia will further improve the clinical use of this old but trusted technique.
authors.affiliation: Vita-Salute University of Milano, Department of Anesthesiology, Istituto di Ricovero e Cura a Carattere Scientifico H. San Raffaele, Milan, Italy. casati.andrea@hsr.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Casati
authors.forename: Federico
authors.initials: F
authors.lastname: Vinciguerra