Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy.
OBJECTIVE
The use of medicinal plants for the treatment of human diseases has increased worldwide. Many of them are used by oral administration and, after absorption, may affect many organs. Therefore, this study aimed at assessing the effects of the aqueous extract of Sida cordifolia leaves, popularly known in Brazil as "malva-branca", on liver regeneration.


METHODS
Twenty rats were divided into four groups: control, Sida100, Sida200 and Sida400 groups. All animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of Sida cordifolia, respectively. Immediately after this, they underwent 67% partial hepatectomy. Twenty four hours later, their livers were removed. Hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC-10 monoclonal antibody.


RESULTS
Sida100 and Sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively).


CONCLUSIONS
The aqueous extract of Sida cordifolia stimulates liver regeneration after 67% partial hepatectomy in rats.
Silva
Renata Lemos
RL
Department of Medicine, Federal University of Sergipe, Brazil.
Melo
Gustavo Barreto de
GB
Melo
Valdinaldo Aragão de
VA
Antoniolli
Angelo Roberto
AR
Michellone
Paulo Roberto Teixeira
PR
Zucoloto
Sérgio
S
Picinato
Maria Aparecida Neves Cardoso
MA
Franco
Clarice Fleury Fina
CF
Mota
Gustavo de Assis
Gde A
Silva
Orlando de Castro e
Ode C
D000818:Animals; D004195:Disease Models, Animal; D006498:Hepatectomy; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D019660:Malvaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D018809:Proliferating Cell Nuclear Antigen; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
D010936:Plant Extracts; D028321:Plant Preparations; D018809:Proliferating Cell Nuclear Antigen