Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay.
A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa (W. SMITH) RALFS, collected in deep sea water from Toyama Bay. The polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. It showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices (CC50/IC50) of 270, 510 and 32, respectively. Naviculan also showed an inhibitory effect on cell-cell fusion between CD4-expressing and human immunodeficiency virus (HIV) gp160-expressing cells that was used as a model system of infection with HIV.
Lee
Jung-Bum
JB
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan. lee@pha.u-toyama.ac.jp
Hayashi
Kyoko
K
Hirata
Megumi
M
Kuroda
Eiko
E
Suzuki
Eiko
E
Kubo
Yoshihiro
Y
Hayashi
Toshimitsu
T
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D017377:Diatoms / Q000737:chemistry*; D006678:HIV / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology*; D014709:Vero Cells
D000998:Antiviral Agents; D011134:Polysaccharides