Possible antipsychotic effects of minocycline in patients with schizophrenia.
We present two cases of patients with schizophrenia treated with minocycline. Minocycline (a second-generation tetracycline) is an established and safe broad-spectrum antibiotic that crosses the blood-brain barrier, with additional efficacy for diseases such as acne and rheumatoid arthritis. Animal studies have suggested that minocycline may prevent progression of some neurological disorders. Moreover, it has been reported that minocycline might have antidepressant effects. We report two cases of acute schizophrenia with predominant catatonic symptoms that responded to minocycline.
Miyaoka
Tsuyoshi
T
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo 693-8501, Japan. miyanyan@med.shimane-u.ac.jp
Yasukawa
Rei
R
Yasuda
Hideaki
H
Hayashida
Maiko
M
Inagaki
Takuji
T
Horiguchi
Jun
J
D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents; D004569:Electroencephalography; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D018967:Risperidone / Q000627:therapeutic use; D012560:Schizophrenia, Catatonic / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents; D014150:Antipsychotic Agents; D008911:Minocycline; D006220:Haloperidol; D018967:Risperidone