title: A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones.
abstract: A sequential, organocatalysed asymmetric reaction to access chiral 1,2-oxazines from achiral ketone starting materials is reported, which proceeds in moderate to good yields and excellent enantioselectivity.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Sirirat
authors.initials: S
authors.lastname: Kumarn
authors.forename: David M
authors.initials: DM
authors.lastname: Shaw
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D006900:Hydroxylation; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D020005:Propanols / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007659:Ketones; D010078:Oxazines; D020005:Propanols; D011758:Pyrroles; C006463:allyl alcohol