title: Hyperbaric oxygen therapy in orthopedic conditions: an evaluation of safety.
abstract: BACKGROUND
  Because of the documented cellular and biochemical benefits of hyperbaric oxygen (HBO), HBO therapy is applied now with increasing frequency to various orthopedic conditions. Many traumatologists and orthopedic surgeons might refer their patients for adjuvant HBO therapy. However, the potential risks and risk-benefit ratio have often been underemphasized in therapeutic trials.
  
  
  METHODS
  From October 2002 to September 2004, 240 patients with a total of 4,638 treatments received HBO therapy at the hyperbaric medicine center of our institution on an identical treatment protocol. HBO therapy patient treatment logs were reviewed to analyze the incidence of complications during HBO treatment.
  
  
  RESULTS
  The overall incidence of complications was 1.83%. Over 94% of treatment complications were mild to moderate and designated as minor complications; fewer than 6% were severe or life threatening and designated as major complications. The incidence of major complications (central nervous system [CNS] oxygen toxicity in this series) was 0.109%. There was no mortality. Two patients with unusual presentation of CNS oxygen toxicity were observed during the study period.
  
  
  CONCLUSIONS
  HBO therapy in orthopedic conditions is considered as a safe treatment because of a very low complication rate; however, analysis of patients with CNS oxygen toxicity revealed its unpredictability and inevitability. Although it is common sense that patients who develop a seizure in the hospital need help from the medical staff, it cannot be done in a monoplace hyperbaric chamber because of pressure unequalization. Therefore, a multiplace chamber equipped with an antechamber for medical contingency is possibly the better facility in consideration of safety.
authors.affiliation: Department of Orthopaedics, Chang Gung Memorial Hospital at Chia-Yi, Taiwan. kc2672@adm.cgmh.org.tw
authors.forename: Kuo-Chin
authors.initials: KC
authors.lastname: Huang
authors.forename: Wei-Hsiu
authors.initials: WH
authors.lastname: Hsu
authors.forename: Kuo-Ti
authors.initials: KT
authors.lastname: Peng
authors.forename: Tsung-Jen
authors.initials: TJ
authors.lastname: Huang
authors.forename: Robert Wen-Wei
authors.initials: RW
authors.lastname: Hsu
mesh_terms: D000328:Adult; D000368:Aged; D000648:Amnesia, Retrograde / Q000209:etiology; D001273:Atmosphere Exposure Chambers; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009985:Orthopedics / Q000379:methods*; D018570:Risk Assessment; D012449:Safety; D013226:Status Epilepticus / Q000209:etiology*