title: Discontinued drugs in 2005: oncology drugs.
abstract: This perspective is the second in a series of papers discussing drugs dropped from development in 2005, of which 20 were being developed for cancer. Of these 20, 60% were biological agents and included 3 cancer vaccine (e.g., Canvaxin) and 2 antisense oligonucleotide (e.g., aprinocarsen sodium). Overall, 10 cancer drugs were discontinued in Phase I, 6 in Phase II and 4 at Phase III. This paper surveys drugs discontinued in the oncology arena in 2005 by stage of development and class of compound, suggesting some reasons for their failure.
authors.affiliation: CRT Development Laboratory, Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, UK. lkelland@cancertechnology.com
authors.forename: Lloyd
authors.initials: L
authors.lastname: Kelland
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D015507:Drugs, Investigational / Q000627:therapeutic use; D006801:Humans; D017211:Treatment Failure
chemical_list: D000970:Antineoplastic Agents; D015507:Drugs, Investigational