title: Pathophysiology of dystonia.
abstract: Understanding of the pathophysiology of dystonia derives primarily from studies of focal dystonias. Physiological investigations have revealed a number of abnormalities that may reflect the genetic substrate that predisposes certain individuals to develop dystonia. There is a loss of inhibition in the central nervous system, and a loss of surround inhibition specifically. Plasticity is increased, and there are sensory abnormalities. Which of these disorders is primary is uncertain.
authors.affiliation: Human Motor Control Section, NINDS, NIH, Bethesda, MD, USA. hallettm@ninds.nih.gov
authors.forename: M
authors.initials: M
authors.lastname: Hallett
mesh_terms: D000818:Animals; D004421:Dystonia / Q000503:physiopathology*; D006801:Humans; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D012677:Sensation / Q000502:physiology