Antiatherogenic and radioprotective role of folic acid in whole body gamma-irradiated mice.
Free radical mediated oxidative damage is one of the prime factors for atherogenic changes in humans. We have shown that the folic acid administration reduced the risk of the atherogenic factors induced by gamma-radiation. Folic acid administration prevented the radiation induced increase in the plasma lipoprotein lipase activity and also prevented the radiation-induced increase in the hepatic cholesterol and triglycerides levels. These results indicate the role of folic acid as an antiatherogenic agent. Further, we also report the radioprotective property of folic acid as demonstrated by reduction in the radiation induced membrane damage as measured by lipid peroxidation products and DNA damage, which was measured by alkaline comet assay.
Pote
Madan Sadashiv
MS
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India.
Gandhi
Nitin Motilal
NM
Mishra
Kaushala Prasad
KP
D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy*; D002784:Cholesterol / Q000032:analysis; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D005492:Folic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D005720:Gamma Rays; D007962:Leukocytes / Q000187:drug effects / Q000528:radiation effects; D008049:Lipase / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000032:analysis; D014916:Whole-Body Irradiation
D008074:Lipoproteins; D011837:Radiation-Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D005492:Folic Acid; D002784:Cholesterol; D008049:Lipase