title: A human lymph node in vitro--challenges and progress.
abstract: Extracorporeal human lymphatic organs are expected to be excellent tools in the study of human molecular and cellular bases of the immunologic balance and tissue harmony. A rational approach and process to design a device and a procedure to recreate the human lymph node environment in vitro is described with emphasis on T-cell activation. Based on this approach, a bioreactor and a process supporting self-assembly of human lymphatic tissues due to proper emulation of human architecture and homeostasis could be developed.
authors.affiliation: ProBioGen AG, Berlin, Germany. christoph.giese@probiogen.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Giese
authors.forename: Christian D
authors.initials: CD
authors.lastname: Demmler
authors.forename: Richard
authors.initials: R
authors.lastname: Ammer
authors.forename: Stefan
authors.initials: S
authors.lastname: Hartmann
authors.forename: Annika
authors.initials: A
authors.lastname: Lubitz
authors.forename: Lilja
authors.initials: L
authors.lastname: Miller
authors.forename: Riccarda
authors.initials: R
authors.lastname: Müller
authors.forename: Uwe
authors.initials: U
authors.lastname: Marx
mesh_terms: D019149:Bioreactors; D002454:Cell Differentiation; D005782:Gels; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology*; D009940:Organoids / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D005782:Gels