title: MR diffusion tensor imaging and fiber tracking in inflammatory diseases of the spinal cord.
abstract: OBJECTIVE
  Our aim was to study the fractional anisotropy (FA) variations and the fiber tracking (FT) patterns observed in patients with myelitis.
  
  
  METHODS
  Fifteen patients with symptomatic myelitis and 11 healthy subjects were prospectively selected. We performed T2-weighted and diffusion tensor imaging on a 1.5T MR scanner. FA and apparent diffusion coefficient maps were computed in both healthy subjects and patients. In each patient, we performed FT to study pathologic aspects on this imaging method. FA data were analyzed by using z-scores.
  
  
  RESULTS
  For the healthy subjects, averaged FA values ranged from 0.745 to 0.751. All abnormal areas seen on T2-weighted imaging had a significantly decreased FA value. In 9 patients (60%), FA maps showed decreased FA areas, whereas T2-weighted imaging findings were normal. These areas matched the neurologic deficit in 33%. Eighty percent of patients had multiple decreased FA areas. Five patients (33%) had increased FA values in normal T2-weighted areas.
  
  
  CONCLUSIONS
  We observed specific FA and FT pattern variations in patients with myelitis.
authors.affiliation: Department of Neuroradiology, CHU de Bicêtre, Le Kremlin Bicêtre, France.
authors.forename: J
authors.initials: J
authors.lastname: Renoux
authors.forename: D
authors.initials: D
authors.lastname: Facon
authors.forename: P
authors.initials: P
authors.lastname: Fillard
authors.forename: I
authors.initials: I
authors.lastname: Huynh
authors.forename: P
authors.initials: P
authors.lastname: Lasjaunias
authors.forename: D
authors.initials: D
authors.lastname: Ducreux
mesh_terms: D000328:Adult; D016880:Anisotropy; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis; D009187:Myelitis / Q000175:diagnosis* / Q000209:etiology; D009188:Myelitis, Transverse / Q000175:diagnosis; D009412:Nerve Fibers / Q000473:pathology*; D009460:Neurologic Examination; D011446:Prospective Studies; D012016:Reference Values; D012507:Sarcoidosis / Q000175:diagnosis; D013116:Spinal Cord / Q000473:pathology*