[Metabolism of the main substance of the connective tissue in chronic obstructive pulmonary disease].
OBJECTIVE
To reveal metabolic disturbances of connective tissue main substance in chronic obstructive pulmonary disease (COPD) and to assess their informative value in determination of treatment efficacy.


METHODS
Peripheral blood of 130 COPD patients was studied for total glycosaminoglycanes, hyaluronidase activity, sialic acids fractions (free, oligobound and proteinbound), fucose fractions (oligobound and proteinbound) and activity of sialidase.


RESULTS
The levels of total glycosaminoglycanes, sialo- and fucose-containing compounds in the blood change with COPD severity and phase of the disease.


CONCLUSIONS
The data obtained may be used to assess activity of respiratory inflammation and efficacy of the treatment.
Vakhrushev
Ia M
IaM
Ermakov
G I
GI
Sharaev
P N
PN
D003238:Connective Tissue / Q000378:metabolism*; D005260:Female; D005643:Fucose / Q000097:blood; D006025:Glycosaminoglycans / Q000097:blood; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000097:blood; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000628:therapy; D012720:Severity of Illness Index; D012794:Sialic Acids / Q000097:blood; D016896:Treatment Outcome
D006025:Glycosaminoglycans; D012794:Sialic Acids; D005643:Fucose; D009439:Neuraminidase; D006821:Hyaluronoglucosaminidase