Evaluation of liver support systems for preclinical testing by animal trials.
In the present review, various animal models of acute liver failure are reviewed with respect to their suitability for evaluating liver support systems (LSS) according to envisaged modes of therapy. In order to increase the value of the preclinical testing of LSS, it would be advantageous to include more than one animal model in the evaluation program. It is possible to identify appropriate sets of models, which make a suitable test system for particular clinical applications. A standardization of evaluation methods between testing groups would also be beneficial to the field of liver support.
Seleverstov
Oleksandr
O
Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, Leipzig, Germany. alex_seleverstov@yahoo.de
Bader
Augustinus
A
D000818:Animals; D004195:Disease Models, Animal; D017093:Liver Failure / Q000628:therapy*; D019164:Liver, Artificial; D012107:Research Design