title: Neoplastic stem cells: a novel therapeutic target in clinical oncology.
abstract: Cancer is among the leading causes of morbidity and mortality in the Western world. Despite recent advances, most therapeutic approaches fail to eradicate the entire neoplastic clone. The remaining cells often develop metastasis and/or recurrences and therefore may represent attractive targets of therapy. A new exciting concept in this regard suggests that each neoplasm represents a heterogeneous population of cells that pertain to long-term tumor growth both in vivo in the natural host and in experimental animals. This concept postulates the existence of small fractions of 'tumor stem cells' that exhibit a capacity for self-renewal and unlimited growth and therefore are distinct from their progeny. Based on these hypotheses, the targeting of neoplastic stem cells is considered indispensable for eradication of the entire clone and for the development of curative treatment approaches. However, tumor stem cells often may be quiescent cells and may express a different profile of targets compared with 'more mature' tumor cells. Therefore, current efforts have attempted to characterize target expression profiles in cancer stem cells in various malignancies. In the this review, the authors have provided a brief summary of the current knowledge of neoplastic stem cells and the application of respective concepts in translational oncology with the ultimate objective of improving anticancer therapy.
authors.affiliation: Bone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria. axelschulenburg@yahoo.de
authors.forename: Axel
authors.initials: A
authors.lastname: Schulenburg
authors.forename: Herbert
authors.initials: H
authors.lastname: Ulrich-Pur
authors.forename: Dietmar
authors.initials: D
authors.lastname: Thurnher
authors.forename: Boban
authors.initials: B
authors.lastname: Erovic
authors.forename: Stefan
authors.initials: S
authors.lastname: Florian
authors.forename: Wolfgang R
authors.initials: WR
authors.lastname: Sperr
authors.forename: Peter
authors.initials: P
authors.lastname: Kalhs
authors.forename: Brigitte
authors.initials: B
authors.lastname: Marian
authors.forename: Friedrich
authors.initials: F
authors.lastname: Wrba
authors.forename: Christoph C
authors.initials: CC
authors.lastname: Zielinski
authors.forename: Peter
authors.initials: P
authors.lastname: Valent
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000502:physiology; D001932:Brain Neoplasms / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D002277:Carcinoma / Q000473:pathology; D005909:Glioblastoma / Q000473:pathology; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology; D008495:Medical Oncology / Q000379:methods*; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000502:physiology*; D015513:Oncogene Proteins / Q000502:physiology; D010641:Phenotype; D011230:Precancerous Conditions / Q000473:pathology; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology
chemical_list: D000954:Antigens, Surface; D009363:Neoplasm Proteins; D015513:Oncogene Proteins