title: Pathology of the appendix in children: an institutional experience and review of the literature.
abstract: BACKGROUND
  The appendix can be affected by a variety of congenital and acquired diseases, but acute appendicitis is the most common pathology found in the pediatric population.
  
  
  OBJECTIVE
  This is a retrospective review of all appendectomies performed during a 2-year period at a major children's hospital with a review of the literature regarding the most common pathologic findings.
  
  
  METHODS
  The pathology database was reviewed for appendectomy specimens, and patient medical records were evaluated to determine the age, gender, race and operative diagnosis. All slides were reviewed and the histologic findings were recorded.
  
  
  RESULTS
  A total of 392 appendectomies were performed, including 68 incidental appendectomies and 324 performed for clinical suspicion of acute appendicitis. In 247 of the latter, acute appendicitis was confirmed histologically, and of the remainder 14 were interval appendectomies, 2 had findings suspicious for Crohn disease, 1 confirmed diverticulitis and 60 were histologically negative for appendicitis.
  
  
  CONCLUSIONS
  Acute appendicitis is the most common pathologic cause of appendectomy, but various other pathologic entities are found in children. Examination of the appendix is warranted even when it appears normal on exploration.
authors.affiliation: Department of Pathology, Children's Hospital of Michigan, Wayne State University, 3901 Beaubien St., Detroit, MI 48201-2119, USA. rrabah@dmc.org
authors.forename: Raja
authors.initials: R
authors.lastname: Rabah
mesh_terms: D000006:Abdomen, Acute; D001062:Appendectomy; D001064:Appendicitis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D001065:Appendix / Q000473:pathology*; D002429:Cecal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D012189:Retrospective Studies