Interactions between schistosomiasis and infection with HIV-1.
In many regions of the world, both schistosomiasis and HIV/AIDS are endemic, resulting in patients harbouring co-infections. Because interaction with host CD4(+) T cells is a characteristic of schistosome as well as HIV-1 infections, bi-directional disease effects may be sufficiently different from sequelae caused by either infectious agent alone to warrant alteration of public health approaches in areas of co-endemnicity. Studies published over the past decade provide useful insights into interactions between schistosomiasis and infection with HIV-1, and overall support the hypothesis that special emphasis on treatment of schistosomiasis in populations with elevated prevalence or risk of HIV-1 infection is justified.
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Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Atlanta, Georgia, USA. was4@cdc.gov
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000469:parasitology* / Q000517:prevention & control; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D012552:Schistosomiasis / Q000150:complications* / Q000453:epidemiology / Q000469:parasitology*