Dietary treatment of gluten neuropathy.
We studied the effect of a gluten-free diet in patients with idiopathic sensorimotor axonal neuropathy and circulating antigliadin antibodies. Consecutive patients underwent baseline neurophysiological assessment and were offered a gluten-free diet. Those who went on the diet formed the intention-to-treat group and those who did not were the control group. Repeat neurophysiological assessment and subjective evaluation of neuropathy symptoms were performed at 1 year. A total of 35 patients participated in the study, with 25 patients going on the diet and 10 not doing so. There was a significant difference in the change of sural sensory action potentials (pre-defined primary endpoint), with evidence of improvement in the intention-to-treat group and deterioration in the control group. Subjective change in neuropathy symptoms also showed significant differences, with patients in the intention-to-treat group reporting improvement and those in the control group reporting deterioration. Gluten-free diet may thus be a useful therapeutic intervention for patients with gluten neuropathy.
Hadjivassiliou
Marios
M
Department of Neurology, The Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK. m.hadjivassiliou@sheffield.ac.uk
Kandler
Rosalind H
RH
Chattopadhyay
Arup K
AK
Davies-Jones
Aelwyn G B
AG
Jarratt
John A
JA
Sanders
David S
DS
Sharrack
Basil
B
Grünewald
Richard A
RA
D000368:Aged; D002446:Celiac Disease / Q000209:etiology*; D018753:Diet, Protein-Restricted / Q000379:methods*; D005260:Female; D005983:Glutens / Q000378:metabolism*; D006801:Humans; D008297:Male; D011115:Polyneuropathies / Q000150:complications* / Q000178:diet therapy*; D016896:Treatment Outcome
D005983:Glutens