title: [The influence of gamma-irradiation in low doses on the rate of dominant lethal mutations in drosophila melanogaster].
abstract: The dose-rate effect of acute and chronic irradiation in the dose of 0.2 Gy in Drosophila melanogaster repair (mei-41, mus209 [Russian character: see text] mus309) and free radicals detoxication (sod) mutant strains was investigated. Was shown the lack of dose rate effect on the rate of dominant lethal mutations in mei-41, mus209 and sod. However in mus309, that has defect in the main Drosophila pathway of the DNA double strand breack repair, the increase of the mutation rate after chronic irradiation was observed (inverse dose-rate effect). The obtained results suggest the main role of DNA double strand breack repair in dose-rate effect formation in Drosophila.
authors.forename: M V
authors.initials: MV
authors.lastname: Shaposhnikova
authors.forename: V G
authors.initials: VG
authors.lastname: Zaĭnullin
mesh_terms: D000818:Animals; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics*; D004307:Dose-Response Relationship, Radiation; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics*; D005720:Gamma Rays; D005799:Genes, Dominant; D017344:Genes, Insect / Q000528:radiation effects*; D005804:Genes, Lethal / Q000528:radiation effects*; D016296:Mutagenesis; D009154:Mutation