title: Age at menopause predicts age at onset of Parkinson's disease.
abstract: We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.
authors.affiliation: Dipartimento di Neuroscienze Cliniche, University of Palermo, Palermo, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ragonese
authors.forename: Marco
authors.initials: M
authors.lastname: D'Amelio
authors.forename: Graziella
authors.initials: G
authors.lastname: Callari
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Salemi
authors.forename: Letterio
authors.initials: L
authors.lastname: Morgante
authors.forename: Giovanni
authors.initials: G
authors.lastname: Savettieri
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D010300:Parkinson Disease; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors