Regions of high differentiation--worth a check.
B. Boursot and K. Belkhir in this issue of Genome Research point to an ascertainment bias in my use of SNPs to identify regions of high differentiation between a pair of house mouse subspecies. Here, I discuss additional points to consider and argue that the ultimate test for such regions should be an independent confirmation using unrelated samples. I provide evidence that regions of high differentiation as identified from laboratory strains and potentially biased SNP markers can be confirmed and therefore are worth a deeper investigation.
Harr
Bettina
B
Institute for Genetics, Department of Evolutionary Genetics, 50674 Köln, Germany.
D000818:Animals; D015982:Bias; D019143:Evolution, Molecular; D014644:Genetic Variation; D023281:Genomics / Q000379:methods*; D051379:Mice / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013045:Species Specificity