title: Mumps resurgence in the United States.
abstract: The recent mumps epidemic in the central United States has generated a large amount of public concern. A total of 2597 mumps cases have been reported in the United States in 11 states since January 1, 2006, representing a marked resurgence of mumps in a single year. The majority of these recent cases have occurred in college students age 18 to 25 years. Most were vaccinated with 2 doses of measles, mumps, and rubella-containing vaccines. Such outbreaks provide an opportunity for clinicians to review the clinical presentation, diagnosis, and morbidity of vaccine-preventable infections and also to review immunologic mechanisms and practice guidelines that might contribute to poor vaccine responses. A review of mumps is provided with discussion of potential mechanisms for vaccine failure.
authors.affiliation: Allergy/Immunology Section, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, USA.
authors.forename: Vikas S
authors.initials: VS
authors.lastname: Kancherla
authors.forename: I Celine
authors.initials: IC
authors.lastname: Hanson
mesh_terms: D000293:Adolescent; D000328:Adult; D004196:Disease Outbreaks; D006801:Humans; D009107:Mumps / Q000453:epidemiology*; D009108:Mumps Vaccine; D014481:United States
chemical_list: D009108:Mumps Vaccine