In vitro ADME medium/high-throughput screening in drug preclinical development.
The study of the ADME features of the huge number of new chemical entities (NCEs) produced mainly by combinatorial chemistry has become a bottleneck in the drug development process. In response the pharmaceutical industry is involved in the development of new medium/high-throughput screening capabilities. The aim of this paper is to review some of the available in vitro ADME systems adapted to screening requirements together with the technological approaches which can be linked to medium/high-throughput molecular screening.
Lahoz
A
A
Unidad de Hepatología Experimental. Centro de Investigación, Hospital La Fe, Avda. Campanar 21, 46009-Valencia, Spain.
Gombau
L
L
Donato
M T
MT
Castell
J V
JV
Gómez-Lechón
M J
MJ
D000818:Animals; D002478:Cells, Cultured; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D010599:Pharmacokinetics