title: Knowledge of epigenetic influence for prostate cancer therapy.
abstract: Prostate cancer is one of the most prevalent cancers in men in many countries, increasing in frequency with age through the most advanced years. The standard treatment for newly diagnosed metastatic tumors is androgen ablation. However, advanced prostate cancer nevertheless often develops in many cases. Although hormonal manipulation and chemotherapy have uncertain value for advanced lesions, especially androgen-independent, recent studies of docetaxel-based chemotherapy in men with androgen-independent prostate cancer have shown a survival benefit. Intensive investigations have shown that aberrant epigenetic features. including aberrant DNA methylation, make an important contribution to carcinogenesis as well as genetic alterations. Hypermethylation of CpG islands in promoter regions can lead to silencing of tumor-suppressor genes, while hypomethylation of the genome leads to instability. This review attempts to provide up-to-date information regarding the significance of epigenetics for human prostate cancer, with aberrations offering dues to therapy and possibly also providing targets for anticancer drugs.
authors.affiliation: Laboratory for Medical Engineering, Division of Materials Science and Chemical Engineering, Graduate School of Engineering, Yokohama National University, Yokohama, Japan. mawata@chemeng.bsk.ynu.ac.jp
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Watanabe
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Takagi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kami
authors.forename: Minoru
authors.initials: M
authors.lastname: Toyota
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Hirokawa
authors.forename: Taizo
authors.initials: T
authors.lastname: Shiraishi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D044127:Epigenesis, Genetic / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents