title: Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect.
abstract: We report a 69-year-old man with cytokine-resistant metastatic renal cell carcinoma treated with reduced-intensity unrelated cord blood transplantation. The patient achieved durable donor engraftment with minimal graft-versus-host disease. The patient showed regression of metastatic disease, providing the first evidence of a graft-versus-tumor effect on a solid tumor resulting from cord blood graft.
authors.affiliation: Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan. takami@med3.m.kanazawa-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Takami
authors.forename: H
authors.initials: H
authors.lastname: Takamatsu
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Ishiyama
authors.forename: H
authors.initials: H
authors.lastname: Okumura
authors.forename: K
authors.initials: K
authors.lastname: Ohata
authors.forename: H
authors.initials: H
authors.lastname: Konaka
authors.forename: H
authors.initials: H
authors.lastname: Asakura
authors.forename: M
authors.initials: M
authors.lastname: Namiki
authors.forename: S
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D036101:Cord Blood Stem Cell Transplantation; D006086:Graft vs Host Disease / Q000150:complications; D020350:Graft vs Tumor Effect; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D009362:Neoplasm Metastasis / Q000628:therapy; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome