Anti-tumor therapeutic molecules that target the programmed cell death machinery.
Apoptosis is a process that governs the elimination of unwanted, damaged, or infected cells in most organisms. Defects in its execution are associated with several diseases, including cancer. Herein, we discuss novel molecules with potential anti-tumor activity that target components of the apoptotic machinery, specifically Bcl-2 proteins, IAPs and caspases.
Ivanovska
Iva
I
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Muhoro
Clare N
CN
Irusta
Pablo M
PM
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism
D000970:Antineoplastic Agents