Diagnostic usefulness of B-type natriuretic peptide and functional consequences of muscle alterations in COPD and chronic heart failure.
COPD affects up to one third of patients with chronic heart failure. The coexistence of COPD and chronic heart failure presents clinicians with diagnostic and therapeutic challenges. Measurement of B-type natriuretic peptide plasma levels facilitates the diagnosis of acute dyspnea in patients known to have both COPD and chronic heart failure. Patients with COPD or chronic heart failure have skeletal muscle abnormalities that limit functional capacity independently from primary organ failure. Exercise training reverses skeletal muscle abnormalities in patients with COPD or chronic heart failure and may be particularly indicated in patients with coexistent COPD and chronic heart failure.
Jelic
Sanja
S
Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, PH 8, Room 840, 630 West 168th St, New York, NY 10032, USA. sj366@columbia.edu
Le Jemtel
Thierry H
TH
D015415:Biomarkers / Q000097:blood; D015444:Exercise; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000534:rehabilitation; D006801:Humans; D018908:Muscle Weakness / Q000097:blood / Q000175:diagnosis* / Q000534:rehabilitation; D009133:Muscular Atrophy / Q000097:blood / Q000175:diagnosis* / Q000534:rehabilitation; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000175:diagnosis* / Q000534:rehabilitation; D016896:Treatment Outcome
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain