Luminescence and photophysical properties of benzo[a]phenothiazines--therapeutic, physico-chemical, and analytical applications.
Luminescence studies on a series of new 12H-benzo[a]phenothiazines (BPHTs), possessing potentially useful antitumor therapeutic properties, are reviewed. The electronic absorption and fluorescence spectral properties of BPHTs, as well as their triplet- and singlet-excited states luminescence quenching are reviewed. Ground-state and singlet-excited state dipole moments and solvatochromic relationships are also described for these compounds. Studies on the formation of inclusion complexes between BPHTs and cyclodextrins (CDs), including CD-enhanced fluorescence, and thermodynamic constants and molecular geometry of these complexes, are discussed. The BPHTs antitumor properties in relation to their pi-electron density, and the physico-chemical and analytical applications based on their fluorescence and photophysical properties are also presented. This review article is based on selected literature data published in the last ten years (1993-2004).
Gaye-Seye
Mame Diabou
MD
ITODYS, Université Paris 7--Denis-Diderot, Associé au CNRS UMR 70-86, 1, rue Guy de la Brosse, 75005 Paris, France.
Aaron
Jean-Jacques
JJ
Párkányi
Cyril
C
Motohashi
Noboru
N
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis / Q000737:chemistry / Q000627:therapeutic use; D002627:Chemistry, Physical / Q000639:trends; D006801:Humans; D049408:Luminescent Agents / Q000032:analysis / Q000737:chemistry* / Q000627:therapeutic use*; D010640:Phenothiazines / Q000032:analysis / Q000737:chemistry* / Q000627:therapeutic use*; D010777:Photochemistry / Q000639:trends; D013050:Spectrometry, Fluorescence / Q000639:trends
D000970:Antineoplastic Agents; D049408:Luminescent Agents; D010640:Phenothiazines; C107575:benzophenothiazine