Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC).
BACKGROUND
The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected.


METHODS
We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped.


RESULTS
Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12.


CONCLUSIONS
These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.
Baffoe-Bonnie
Agnes B
AB
Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Kittles
Rick A
RA
Gillanders
Elizabeth
E
Ou
Liang
L
George
Asha
A
Robbins
Christiane
C
Ahaghotu
Chiledum
C
Bennett
James
J
Boykin
William
W
Hoke
Gerald
G
Mason
Terry
T
Pettaway
Curtis
C
Vijayakumar
Srinivasan
S
Weinrich
Sally
S
Jones
Mary P
MP
Gildea
Derek
D
Riedesel
Erica
E
Albertus
Julie
J
Moses
Tracy
T
Lockwood
Erica
E
Klaric
Meghan
M
Faruque
Mezbah
M
Royal
Charmaine
C
Trent
Jeffrey M
JM
Berg
Kate
K
Collins
Francis S
FS
Furbert-Harris
Paulette M
PM
Bailey-Wilson
Joan E
JE
Dunston
Georgia M
GM
Powell
Isaac
I
Carpten
John D
JD
D001741:Black or African American / Q000235:genetics*; D000368:Aged; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics*; D014481:United States
D005819:Genetic Markers