ACE I/D polymorphism in different etiologies of ischemic stroke.
OBJECTIVE
Data concerning an association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and ischemic stroke (IS) remain inconsistent. Results of some studies suggest that DD genotype may be a risk factor for small vessel disease (SVD) stroke. Here, we investigated whether this polymorphism is associated with IS of different etiologies in a Polish population.


METHODS
Ischemic stroke etiology was established according to the TOAST criteria. We studied 92 stroke patients with large vessel disease and their 184 matched controls; 96 stroke patients with SVD and 192 controls; 180 patients with cardioembolic stroke (CE) and 180 controls. ACE I/D polymorphism was determined using the polymerase chain reaction method.


RESULTS
The distribution of ACE genotypes and alleles was essentially the same in all analyzed IS subtypes and their matched controls.


CONCLUSIONS
We failed to find an association between ACE polymorphism and etiological subtypes of IS in a Polish population.
Pera
J
J
Department of Neurology, Jagiellonian University, Krakow, Poland. pera@su.krakow.pl
Slowik
A
A
Dziedzic
T
T
Wloch
D
D
Szczudlik
A
A
D000368:Aged; D002545:Brain Ischemia / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011044:Poland; D011110:Polymorphism, Genetic / Q000235:genetics*; D020521:Stroke / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology
D005819:Genetic Markers; D007703:Peptidyl-Dipeptidase A