Ion-induced biomolecular radiation damage: from isolated nucleobases to nucleobase clusters.
A large number of studies are devoted to the investigation of the biomolecular ionization and fragmentation dynamics underlying biological radiation damage. Most of these studies have been based on gas-phase collisions with isolated DNA building blocks. The radiobiological significance of these studies is often questioned because of the lack of a chemical environment. To clarify this aspect, we studied interactions of keV ions with isolated nucleobases and with nucleobase clusters by means of coincidence time-of-flight spectrometry. Significant changes already show up in the molecular fragmentation patterns of very small clusters.
Schlathölter
Thomas
T
KVI Atomic Physics, Rijksuniversiteit Groningen, Zernikelaan 25, 9747AA Groningen, The Netherlands. tschlat@kvi.nl
Alvarado
Fresia
F
Bari
Sadia
S
Lecointre
Aurelie
A
Hoekstra
Ronnie
R
Bernigaud
Virgil
V
Manil
Bruno
B
Rangama
Jimmy
J
Huber
Bernd
B
D000225:Adenine / Q000737:chemistry; D001482:Base Composition; D001703:Biophysics / Q000379:methods; D002627:Chemistry, Physical / Q000379:methods; D004247:DNA / Q000737:chemistry*; D004583:Electrons; D006860:Hydrogen Bonding; D007477:Ions; D013058:Mass Spectrometry; D008968:Molecular Conformation; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D013053:Spectrophotometry; D013941:Thymine / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry
D007477:Ions; D011687:Purines; D011743:Pyrimidines; D014498:Uracil; D004247:DNA; D000225:Adenine; C030986:pyrimidine; D013941:Thymine