Adipocyte fatty-acid binding protein is closely associated to the porcine FAT1 locus on chromosome 4.
We identified 22 polymorphisms in the adipocyte fatty-acid binding protein (FABP4) gene, a strong positional candidate gene for the FAT1 locus in porcine chromosome 4. The most informative polymorphism, an insertion/deletion in intron 1, together with a single nucleotide polymorphism in intron 3, was genotyped in a cross between Iberian and Landrace pigs. After performing QTL, single marker, and haplotype analyses, we showed that there were at least 2 quantitative trait genes in the FAT1 region and that the FABP4 polymorphism was tightly associated to fatness. A comparison of allelic frequencies in a panel of pig breeds suggested that the Del2634C polymorphism was under indirect selection. We also showed that FABP4 is tightly associated to fatness but not growth. Furthermore, a haplotype analysis suggests that there is genetic heterogeneity at the FAT1 locus within the Landrace breed.
Mercadé
A
A
Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. Anna.mercader@uab.es
Pérez-Enciso
M
M
Varona
L
L
Alves
E
E
Noguera
J L
JL
Sánchez
A
A
Folch
J M
JM
D000818:Animals; D002874:Chromosome Mapping; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D008297:Male; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D013552:Swine / Q000235:genetics*
D050556:Fatty Acid-Binding Proteins