title: Doxycycline-induced staining of permanent adult dentition.
abstract: BACKGROUND
  Doxycycline is the most effective antibiotic for managing brucellosis. Although it is relatively free from side effects, complications involving the skin, nails and teeth may rarely be encountered.
  
  
  METHODS
  Four patients with brucellosis developed yellow-brown discolouration of teeth following a 30-45 day course of doxycycline therapy during summer at a dose of 200mg/day.
  
  
  RESULTS
  All four patients were diagnosed as having doxycycline-induced staining of the permanent dentition. In all cases, the staining completely resolved and the teeth recovered their original colour following abrasive dental cleaning.
  
  
  CONCLUSIONS
  These observations indicate that the incidence of staining of the permanent dentition, as a complication of doxycycline, may be much higher than the literature indicates, especially if treatment is administered during summer months. Fortunately, this complication is reversible and does not require termination of doxycycline therapy. Complete resolution following abrasive cleaning may suggest that an extrinsic mechanism within the dental milieu may be involved in its pathogenesis. Strict avoidance of sunlight exposure during high-dose, long-term doxycycline therapy might prevent the development of this complication.
authors.affiliation: Faculty of Medicine and Dentistry, Kirikkale University, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Ayaslioglu
authors.forename: E
authors.initials: E
authors.lastname: Erkek
authors.forename: A A
authors.initials: AA
authors.lastname: Oba
authors.forename: E
authors.initials: E
authors.lastname: Cebecioğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002006:Brucellosis / Q000188:drug therapy; D002648:Child; D004318:Doxycycline / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012293:Rifampin / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D013472:Sunlight / Q000009:adverse effects; D014075:Tooth Discoloration / Q000139:chemically induced* / Q000628:therapy; D014099:Toothbrushing / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline; D012293:Rifampin; D013307:Streptomycin