Oral progesterone decreases saccadic eye velocity and increases sedation in women.
The aim of this study was to investigate the neurophysiological and behavioural effects of a single dose of progesterone in women. Allopregnanolone is a metabolite of progesterone and a potent positive modulator of the GABA(A) receptor and produces sedative and anxiolytic effects. This study was designed to examine the effect of oral progesterone and the metabolite allopregnanolone in women. Women (n=15) in their follicular phase received oral progesterone (400mg) or placebo. Dependent measures included plasma levels of progesterone and allopregnanolone, saccadic eye velocity (SEV), subjective ratings (visual analogue scales), and reaction time. Administration of progesterone decreased SEV and increased sedation. This effect is probably due to enhanced GABA activity.
van Broekhoven
F
F
Department of Psychiatry, Unit for Clinical Psychopharmacology and Neuropsychiatry, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. f.vanbroekhoven@psy.umcn.nl
Bäckström
T
T
Verkes
R J
RJ
D000042:Absorption; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001519:Behavior / Q000187:drug effects; D016292:Procedural Sedation; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D010919:Placebos; D011280:Pregnanolone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D011374:Progesterone / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D012438:Saccades / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D010919:Placebos; D011374:Progesterone; D011280:Pregnanolone