title: Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction.
abstract: OBJECTIVE
  We sought to investigate the association between increased levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, and total plasma homocysteinemia (tHcy) in patients with acute myocardial infarction (AMI).
  
  
  METHODS
  In 138 patients hospitalized for AMI <24 h on admission, serum levels of ADMA, its symmetric stereoisomer (SDMA) and tHcy were measured.
  
  
  RESULTS
  ADMA was positively associated with SDMA (p<0.001) and tHcy (p=0.03) but not with estimated glomerular filtration rates (eGFR, p=0.96), while tHcy strongly correlated with eGFR (p=0.002) and SDMA (p<0.001). By multiple linear regression, SDMA but not ADMA was independently associated with tHcy (p=0.005).
  
  
  CONCLUSIONS
  Our findings suggest that, in AMI patients, hyperhomocysteinemia is indirectly related to ADMA levels via renal function. Moreover, ADMA level was independent of traditional cardiovascular risk factors in AMI patients. Interestingly, our findings suggest that SDMA could be a good risk indicator for cardiovascular disease in AMI patients.
authors.affiliation: Laboratory of Experimental Cardiovascular Pathophysiology and Pharmacology, IFR100, Faculties of Medecine and Pharmacy, University of Burgundy, Dijon, France.
authors.forename: Claudia
authors.initials: C
authors.lastname: Korandji
authors.forename: Marianne
authors.initials: M
authors.lastname: Zeller
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Guilland
authors.forename: Catherine
authors.initials: C
authors.lastname: Vergely
authors.forename: Pierre
authors.initials: P
authors.lastname: Sicard
authors.forename: Laurence
authors.initials: L
authors.lastname: Duvillard
authors.forename: Philippe
authors.initials: P
authors.lastname: Gambert
authors.forename: Daniel
authors.initials: D
authors.lastname: Moreau
authors.forename: Yves
authors.initials: Y
authors.lastname: Cottin
authors.forename: Luc
authors.initials: L
authors.lastname: Rochette
mesh_terms: D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D012044:Regression Analysis; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013237:Stereoisomerism
chemical_list: D006710:Homocysteine; C018524:N,N-dimethylarginine; D001120:Arginine