title: Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages.
abstract: Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, N-1147 Doan Hall, 410 W. 10th Avenue, Columbus, OH 43210, USA.
authors.forename: J Scott
authors.initials: JS
authors.lastname: Ferguson
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Martin
authors.forename: Abul K
authors.initials: AK
authors.lastname: Azad
authors.forename: Travis R
authors.initials: TR
authors.lastname: McCarthy
authors.forename: Peter B
authors.initials: PB
authors.lastname: Kang
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Voelker
authors.forename: Erika C
authors.initials: EC
authors.lastname: Crouch
authors.forename: Larry S
authors.initials: LS
authors.lastname: Schlesinger
mesh_terms: D000818:Animals; D006801:Humans; D008247:Lysosomes / Q000276:immunology / Q000382:microbiology* / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology* / Q000648:ultrastructure; D008561:Membrane Fusion; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D010587:Phagocytosis; D010588:Phagosomes / Q000276:immunology / Q000382:microbiology* / Q000648:ultrastructure; D037663:Pulmonary Surfactant-Associated Protein D / Q000494:pharmacology*; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology; D016897:Respiratory Burst
chemical_list: D037663:Pulmonary Surfactant-Associated Protein D; D011994:Recombinant Proteins