title: Magnetic field perturbations as a tool for controlling enzyme-regulated and oscillatory biochemical reactions.
abstract: The feasibility of magnetic field perturbations as a tool for controlling enzyme-regulated and oscillatory biochemical reactions is studied. Our approach is based on recent experimental results that revealed magnetic field effects on the in vitro activity of enzyme systems in accordance with the radical pair mechanism. A minimum model consisting of two coupled enzyme-regulated reactions is discussed that combines, in a self-consistent manner, magnetic field-sensitive enzyme kinetics with non-linear dynamical principles. Furthermore, a simple detector mechanism is described that is capable of responding to an oscillatory input. Results reveal that moderate-strength magnetic fields (B=1-100 mT) may effectively alter the dynamics of the system. In particular, a response behavior is observed that depends on: (1) the combination of static and time-varying magnetic fields; (2) the field amplitude; and (3) the field frequency in a non-linear fashion. The specific response behavior is critically determined by the biochemical boundary conditions as defined by the kinetic properties of the system. We propose an experimental implementation of the results based on the oscillatory peroxidase-oxidase reaction controlled by the enzyme horseradish peroxidase.
authors.affiliation: Bioelectromagnetics Laboratory, Department of Radiation Oncology, School of Medicine-AO38, Stanford University, Stanford, CA 94305-5304, USA.
authors.forename: C
authors.initials: C
authors.lastname: Eichwald
authors.forename: J
authors.initials: J
authors.lastname: Walleczek