PVP magnetic nanospheres: biocompatibility, in vitro and in vivo bleomycin release.
OBJECTIVE
To synthesize and characterize a magnetic micromolecular delivery system based on PVP hydrogel with polyvinyl alcohol (PVA) as the crosslinker.


METHODS
The microparticles were successfully prepared using 25 kGy Co-60 gamma-ray irradiation and characterized. Biocompatibility, in vitro and in vivo drug release tests were carried out.


CONCLUSIONS
Bleomycin was quantitatively released with in slightly over 8 h (hours) from the nanospheres containing 1mg bleomycin while the time was longer for those containing 5 mg. On the other hand free bleomycin quantitatively passed through the dialysis baffle with in only 3.5 h. For both 5 and 1 mg of bound bleomycin, it took up to 2 h to reach peak concentration compared to 30 min for the free drug.


CONCLUSIONS
The PVP hydrogel magnetic nanospheres exhibited passive drug release that could be exploited to enhance therapeutic efficacy. The present results indicate that PVP hydrogel based magnetic nanospheres have potential as drug carriers in magnetic guided chemotherapeutic drug delivery.
Guowei
Ding
D
Tongji University Hospital, 50 Chifeng Road, 200092 Shanghai, PR China. tjhosp698@sohu.com
Adriane
Kamulegeya
K
Chen
Xingzai
X
Jie
Chen
C
Yinfeng
Liu
L
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D001761:Bleomycin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005720:Gamma Rays; D006461:Hemolysis / Q000187:drug effects; D008280:Magnetics; D008297:Male; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D017348:Microscopy, Electron, Scanning Transmission; D053758:Nanoparticles; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D011817:Rabbits; D012015:Reference Standards; D013778:Tetrazolium Salts; D013844:Thiazoles; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; D001672:Biocompatible Materials; D013778:Tetrazolium Salts; D013844:Thiazoles; D001761:Bleomycin; D011142:Polyvinyl Alcohol; C022616:thiazolyl blue; D011205:Povidone