title: Synthesis of the ester side chains of some potently antileukemic harringtonia alkaloids from chiral citrates.
abstract: The selective reduction of one of the three carboxyl groups of two chiral citric acid derivatives to the corresponding aldehydes, under Rosenmund conditions, are reported together with the application of these aldehydes to the syntheses of the ester side chains of some potently antileukemic Cephalotaxus alkaloids e.g. anhydroharringtonine.
authors.affiliation: GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts., UK SG1 2NY.
authors.forename: Rachael A
authors.initials: RA
authors.lastname: Ancliff
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Russell
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Sanderson
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D032483:Cephalotaxus / Q000737:chemistry*; D002951:Citrates / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D002951:Citrates; D004952:Esters