A pair of diastereoisomeric steroidal saponins from cytotoxic extracts of Tupistra chinensis rhizomes.
A pair of diastereoisomeric steroidal saponins were obtained from the saponin fraction (SF) of methanol extracts from Tupistra chinensis rhizomes, collected in Shennongjia Forest District, China. Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. The sample SF displayed marked inhibitory action in vitro towards HeLa and HL-60 cancer cell lines at 10 microg/ml by MTT method.
Zou
Kun
K
Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang, PR China. kzou@ctgu.edu.cn
Wang
Junzhi
J
Du
Ming
M
Li
Qing
Q
Tu
Guangzhong
G
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D015394:Molecular Structure; D012015:Reference Standards; D027343:Rhizome / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D012503:Saponins; D013256:Steroids