title: Multi-center validation of the transferability of the magnetic resonance T2* technique for the quantification of tissue iron.
abstract: The transferability of the T2* technique for measurement of tissue iron between magnetic resonance (MR) scanners is unknown. Heart and liver multi-breath-hold T2* sequences were installed on MR scanners at six different sites. T2* was assessed locally in five or more patients with thalassemia major (n=39), and subjects were re-scanned at the standardization center in London. Inter-center reproducibility of T2* in heart and liver was 5.0% and 7.1%, with mean absolute differences in T2* of 1.3 ms and 0.45 ms, respectively. The MR multi-breath-hold T2* technique for tissue iron quantification is transferable between scanners with good reproducibility.
authors.affiliation: Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Tanner
authors.forename: Taigang
authors.initials: T
authors.lastname: He
authors.forename: Mark A
authors.initials: MA
authors.lastname: Westwood
authors.forename: David N
authors.initials: DN
authors.lastname: Firmin
authors.forename: Dudley J
authors.initials: DJ
authors.lastname: Pennell
mesh_terms: D006801:Humans; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards*; D009206:Myocardium / Q000378:metabolism; D017086:beta-Thalassemia / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D007501:Iron