Efficacy of enrofloxacin against severe experimental Anaplasma marginale infections in splenectomized calves.
Four Anaplasma marginale-infected splenectomized calves with greater than 25% parasitized erythrocytes received enrofloxacin at 12.5 mg/kg SC twice, 48 hours apart. Two infected splenectomized calves were designated as untreated controls. A precipitous decline in percent parasitized erythrocytes from 39.13% to less than 1% was observed over 12 days following treatment. However, a self-limiting recrudescence of A. marginale parasites was observed within 30 days after treatment. Untreated control calves became moribund and were euthanized. These data indicate that the regimen of enrofloxacin tested herein ameliorates, but does not eliminate, A. marginale infections in splenectomized calves.
Coetzee
Johann F
JF
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Apley
Michael D
MD
D042322:Anaplasma marginale / Q000187:drug effects* / Q000254:growth & development; D000712:Anaplasmosis / Q000188:drug therapy*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D000077422:Enrofloxacin; D004912:Erythrocytes / Q000382:microbiology; D024841:Fluoroquinolones / Q000627:therapeutic use*; D011897:Random Allocation; D013156:Splenectomy / Q000662:veterinary; D013997:Time Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin