title: Management of clinically diagnosed subacute rhinosinusitis in children under the age of two years: a randomized, controlled study.
abstract: BACKGROUND
  In children, a diagnosis of rhinosinusitis is usually made on clinical grounds. Subacute rhinosinusitis (SRS) may be the cause of persistent cough, low-grade fever, snoring, ear problems and difficult feeding in children under the age of two years.
  
  
  OBJECTIVE
  To compare the efficacy of culture-based antibiotics and empiric amoxicillin-clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.
  
  
  METHODS
  Randomized, controlled study.
  
  
  METHODS
  Sixty children with persistent nasal discharge and nasal obstruction (and other related symptoms) for 30-90 days.
  
  
  METHODS
  Group one (n = 30) received culture-based antibiotics and group two (n = 30) were treated empirically with 40 mg/kg/day of amoxicillin-clavulanate. Treatment was continued for two weeks.
  
  
  RESULTS
  At the end of the three-week follow-up period, statistically significant greater improvements in nasal obstruction (p = 0.037) and nasal discharge (p = 0.003) were seen in group one compared with group two.
  
  
  CONCLUSIONS
  culture-based antibiotics were more efficacious than empiric amoxicillin-clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.
authors.affiliation: Otorhinolaryngology Department, Suez Canal University, Ismailia, Egypt. Dhennawi@yahoo.com
authors.forename: D M
authors.initials: DM
authors.lastname: El-Hennawi
authors.forename: A S
authors.initials: AS
authors.lastname: Abou-Halawa
authors.forename: S R
authors.initials: SR
authors.lastname: Zaher
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination