title: Crystal structures and inhibitors of proteins involved in IL-2 release and T cell signaling.
authors.affiliation: Vertex Pharmaceuticals (Europe) Ltd., Abingdon Oxfordshire OX14 4RY, United Kingdom.
authors.forename: Kieron
authors.initials: K
authors.lastname: Brown
authors.forename: Graham M T
authors.initials: GM
authors.lastname: Cheetham
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000378:metabolism*; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D011494:Protein Kinases / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000378:metabolism* / Q000502:physiology*
chemical_list: D007376:Interleukin-2; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases