Intestinal toxins.
The application of molecular techniques to the study of bacterial pathogenesis has made possible discoveries that are changing the way scientists view the bacterium-host interaction. Today, research on the molecular basis of the pathogenesis of infective diarrheal diseases of necessity transcends established boundaries between cell biology, bacteriology, intestinal pathophysiology, and immunology. A comprehensive approach has been taken here to outline the most recent findings on the interaction between enteric pathogens and their target eukaryotic cells through the elaboration of toxins.
Fasano
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Division of Pediatric Gastroenterology and Nutrition, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. afasano@umaryland.edu