title: Decreased circulating CD34+ stem cells in early Alzheimer's disease: Evidence for a deficient hematopoietic brain support?
abstract: Hematopoietic stem cells contribute to mammalian brain tissue regeneration by transdifferentiation processes. We found decreased counts of circulating CD34+ cells in early Alzheimer's dementia (AD; P = 0.01), which significantly correlated with age (r = -0.661; P = 0.001), cerebrospinal fluid beta-amyloid (Abeta)1-42 (r = -0.467; P = 0.025) and most pronounced the Abeta42/40 ratio (r = -0.688; P = 0.005). Our data suggest a deficient regenerative hematopoietic support for the central nervous system in early AD.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: J M
authors.initials: JM
authors.lastname: Maler
authors.forename: P
authors.initials: P
authors.lastname: Spitzer
authors.forename: P
authors.initials: P
authors.lastname: Lewczuk
authors.forename: J
authors.initials: J
authors.lastname: Kornhuber
authors.forename: M
authors.initials: M
authors.lastname: Herrmann
authors.forename: J
authors.initials: J
authors.lastname: Wiltfang
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D018952:Antigens, CD34 / Q000097:blood*; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D008297:Male; D012038:Regeneration; D013234:Stem Cells
chemical_list: D016229:Amyloid beta-Peptides; D018952:Antigens, CD34