Dendritic protein synthesis, synaptic plasticity, and memory.
Considerable evidence suggests that the formation of long-term memories requires a critical period of new protein synthesis. Recently, the notion that some of these newly synthesized proteins originate through local translation in neuronal dendrites has gained some traction. Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area.
Sutton
Michael A
MA
Division of Biology 114-96, California Institute of Technology, Howard Hughes Medical Institute, Pasadena, CA 91125, USA.
Schuman
Erin M
EM
D000818:Animals; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D014176:Protein Biosynthesis / Q000502:physiology*; D020543:Proteome; D012333:RNA, Messenger / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D013997:Time Factors
D020543:Proteome; D012333:RNA, Messenger