title: [Examination of an imaging method in early Alzheimer disease diagnosis support system (VSRAD)].
abstract: The use of voxel-based morphometry (VBM) has recently become a popular tool for the early diagnosis of Alzheimer disease. The Voxel-Based Specific Regional Analysis System for Alzheimer's Disease (VSRAD) is a clinically useful VBM that employs MRI. However, there has been insufficient information about the influence of the image pickup apparatus and imaging conditions in terms of the value calculated by the sensitivity correction. We therefore reviewed this problem in a volunteer who provided consent. We were able to confirm reproducibility under the same conditions. When changing the image pickup apparatus and conditions, the average Z-score of 0.18+/-0.21 became larger, and the change in Z-score increased when imaging was done in the axial plane. Further, the average Z-score of 0.06+/-0.21 for sensitivity correction use was high on average by 0.19+/-0.16 for phased-array uniformity enhancement (PURE) and low for surface coil intensity correction (SCIC).
authors.affiliation: Department of Radiological Technology, University of Tokyo Hospital.
authors.forename: Masami
authors.initials: M
authors.lastname: Goto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Masumoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yoshiroh
authors.initials: Y
authors.lastname: Satake
authors.forename: Katsuji
authors.initials: K
authors.lastname: Nishida
authors.forename: Kenji
authors.initials: K
authors.lastname: Ino
authors.forename: Keiichi
authors.initials: K
authors.lastname: Yano
authors.forename: Kyohhito
authors.initials: K
authors.lastname: Iida
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mima
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity