title: Treatment failure of nosocomial pertussis infection in a very-low-birth-weight neonate.
abstract: We describe a case of nosocomial maternal transmission of Bordetella pertussis to a very-low-birth-weight (VLBW) neonate in whom treatment was unsuccessful. This case underscores the need for rapid and sensitive PCR diagnosis in VLBW neonates and in parents with clinical signs of pertussis and suggests that standard treatment may not be appropriate for VLBW neonates.
authors.affiliation: Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonacorsi
authors.forename: Caroline
authors.initials: C
authors.lastname: Farnoux
authors.forename: Philippe
authors.initials: P
authors.lastname: Bidet
authors.forename: Valérie
authors.initials: V
authors.lastname: Caro
authors.forename: Sophie
authors.initials: S
authors.lastname: Aizenfisz
authors.forename: Mounir
authors.initials: M
authors.lastname: Benhayoun
authors.forename: Yannick
authors.initials: Y
authors.lastname: Aujard
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D015570:Josamycin / Q000627:therapeutic use*; D008297:Male; D017211:Treatment Failure; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014917:Whooping Cough / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017963:Azithromycin; D015570:Josamycin