title: Huge leiomyoma in a woman with Down syndrome: a case report.
abstract: BACKGROUND
  For patients with Down syndrome, the reproductive period is becoming longer in relation to the increasing lifetime. Thus, the possibility of reproductive disorders is also increasing.
  
  
  METHODS
  A 37-year-old woman with trisomy 21 was hospitalized with uterine myomatosis, which was spreading to the umbilicus. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed, and estrogen replacement was given after surgery.
  
  
  CONCLUSIONS
  The incidence of solid tumors in Down syndrome patients is extremely rare or nonexistent. This case calls attention to reproductive pathology in long-lived women with Down syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, Ataturk Teaching and Training Hospital, Basin Sitesi, Karsiyaka 6346 Street, Number 25, 35540 Izmir, Turkey. alibaloglu@yahoo.com
authors.forename: Ali
authors.initials: A
authors.lastname: Baloglu
authors.forename: Incim
authors.initials: I
authors.lastname: Bezircioglu
authors.forename: Burcu
authors.initials: B
authors.lastname: Cetinkaya
authors.forename: Erdinc
authors.initials: E
authors.lastname: Yavuz
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D018231:Leiomyomatosis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D014594:Uterine Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D014599:Uterus / Q000473:pathology / Q000601:surgery