title: The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.
authors.affiliation: Abteilung NMR-basierte Strukturbiologie, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen, Germany.
authors.forename: Víctor M
authors.initials: VM
authors.lastname: Sánchez-Pedregal
authors.forename: Karel
authors.initials: K
authors.lastname: Kubicek
authors.forename: Jens
authors.initials: J
authors.lastname: Meiler
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lyothier
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.forename: Teresa
authors.initials: T
authors.lastname: Carlomagno
mesh_terms: D000473:Alkanes / Q000737:chemistry* / Q000378:metabolism*; D002219:Carbamates / Q000737:chemistry* / Q000378:metabolism*; D034261:Epothilones / Q000737:chemistry* / Q000378:metabolism; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011485:Protein Binding; D011753:Pyrones / Q000737:chemistry* / Q000378:metabolism*; D012996:Solutions / Q000737:chemistry; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000473:Alkanes; D002219:Carbamates; D034261:Epothilones; D007783:Lactones; D011753:Pyrones; D012996:Solutions; D014404:Tubulin; C071229:discodermolide