title: Exposure to a nutrition supplementation intervention in early childhood and risk factors for cardiovascular disease in adulthood: evidence from Guatemala.
abstract: To study the role of nutrition in the association of birth size and childhood growth with development of cardiovascular disease, the authors in 2002-2004 surveyed 665 men and 790 women aged 25-42 years who had been exposed as children to a community-randomized nutrition supplementation intervention in four villages in eastern Guatemala. Exposure was associated with a lower fasting glucose level (7.0 mg/dl, 95% confidence interval (CI): 0.5, 13.5) for exposure at ages 36-72 months; lower systolic blood pressure (3.0 mmHg, 95% CI: 0.4, 5.6) for exposure at ages 24-60 months; and a lower triglyceride level (sex-adjusted; 22.2 mg/dl, 95% CI: 0.4, 44.1) and higher high density lipoprotein cholesterol level (males only; 4.7 mg/dl, 95% CI: 1.5, 7.9) for exposure prior to age 36 months. Improved nutrition at any age prior to 7 years was not associated with diastolic blood pressure, total or low density lipoprotein cholesterol level, or prevalence of the metabolic syndrome. Interventions designed to address nutrient deficiencies and ameliorate stunting that are targeted at pregnant women and young children are unlikely to increase cardiovascular disease risk later in life and may instead lower the risk.
authors.affiliation: Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. Aryeh.Stein@emory.edu
authors.forename: Aryeh D
authors.initials: AD
authors.lastname: Stein
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Manuel
authors.initials: M
authors.lastname: Ramirez-Zea
authors.forename: Rafael
authors.initials: R
authors.lastname: Flores
authors.forename: Ruben
authors.initials: R
authors.lastname: Grajeda
authors.forename: Paul
authors.initials: P
authors.lastname: Melgar
authors.forename: Usha
authors.initials: U
authors.lastname: Ramakrishnan
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Martorell
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D002648:Child; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D019587:Dietary Supplements / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006166:Guatemala / Q000453:epidemiology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D012307:Risk Factors; D012959:Socioeconomic Factors
chemical_list: D001786:Blood Glucose; D008055:Lipids