title: A comparison of N-butylscopolammonium and lidocaine for control of rectal pressure in horses.
abstract: In its FDA approved formulation, N-butylscopolammonium bromide (Buscopan Injectable Solution, Boehringer Ingelheim Vetmedica) is an anticholinergic spasmolytic agent indicated for management of abdominal pain associated with spasmodic colic, flatulent colic, and simple impactions in horses. Use of this drug ablates gastrointestinal peristalsis and rectal pressure. It ahs been suggested that N-butylscopolammonium bromide could be used to facilitate rectal examinations in horses. This study compared the effects of N-butylscopolammonium bromide versus lidocaine and a saline control on rectal pressure and the number of rectal strains during rectal examination. The results of this study indicate that this drug increases the quality and, presumably, the safety of rectal examinations in horses.
authors.affiliation: Equine Research Center, California State Polytechnic University, Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.
authors.forename: Tong
authors.initials: T
authors.lastname: Luo
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Bertone
authors.forename: Holly M
authors.initials: HM
authors.lastname: Greene
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Wickler
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary; D001003:Anal Canal / Q000187:drug effects*; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002086:Butylscopolammonium Bromide / Q000494:pharmacology*; D003085:Colic / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary; D051517:Digital Rectal Examination / Q000379:methods / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis / Q000188:drug therapy; D006736:Horses / Q000502:physiology; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D011312:Pressure; D011897:Random Allocation; D012449:Safety
chemical_list: D000779:Anesthetics, Local; D010276:Parasympatholytics; D002086:Butylscopolammonium Bromide; D008012:Lidocaine