title: Hematological malignancies in chronic inflammatory bowel diseases: report of five cases and review of the literature.
abstract: Several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory bowel diseases (IBD). Patients needing a prolonged treatment with immunosuppressants, such as azathioprine or methotrexate, with familiarity and genetic predisposition seem to be at a higher risk of leukemia. On the other hand, asthenia, thickness, and fever may be the symptoms of the onset of each kind of hematological malignancy. The finding of anemia, alteration of leukocyte count and large undetermined cells may suggest increased probability of abnormal proliferation of a single white blood cell line. In this report, the occurrence of hematological malignancies is described in five patients affected by IBD (three with ulcerative colitis and two with Crohn's disease) attending our Gastroenterology Unit.
authors.affiliation: Gastroenterology Unit, Department of Clinical Sciences, University La Sapienza, Policlinico Umberto I, Viale del Policlinico 157, Rome 00161, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Crispino
authors.forename: Roberta
authors.initials: R
authors.lastname: Pica
authors.forename: Erika
authors.initials: E
authors.lastname: Angelucci
authors.forename: Adriana
authors.initials: A
authors.lastname: Consolazio
authors.forename: Margherita
authors.initials: M
authors.lastname: Rivera
authors.forename: Claudio
authors.initials: C
authors.lastname: Cassieri
authors.forename: Paolo
authors.initials: P
authors.lastname: Paoluzi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D016393:Lymphoma, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged