title: Diagnosis and treatment of malignant melanoma of the foot.
abstract: BACKGROUND
  Patients diagnosed with melanoma of the foot have been reported to have a poor prognosis. We reviewed our experience at a tertiary-care medical clinic to determine the disease course in patients diagnosed with melanoma of the foot.
  
  
  METHODS
  A retrospective review was performed of 38 patients with a diagnosis of primary or locally recurrent melanoma of the foot treated between January, 1988, and July, 2004. The main outcome measures included methods of diagnosis, clinical and histopathologic features, and patterns of recurrence.
  
  
  RESULTS
  The mean age at diagnosis was 61 years; most were women (58%) and Caucasian (95%). The average time to diagnosis was 17 months. Initial clinical diagnosis had been considered benign in 12 (32%). The median Breslow thickness was 1.75 mm, T1 lesions were the most common, and acral lentiginous melanoma accounted for 42%. Thirteen patients (34%) had ulcerated lesions. Sentinel lymph node biopsy specimens of 25 patients identified four (16%) with metastatic disease. Surgical complications occurred in 12 patients, usually after skin graft or soft-tissue flap reconstruction. Systemic recurrence developed in six patients, four of whom also had regional recurrence.
  
  
  CONCLUSIONS
  Most patients were elderly Caucasian women and most presented with early-stage disease, but diagnosis can be difficult and a subgroup presented with thick melanomas. Reconstructive surgical procedures had a high rate of complications; however, overall functional outcomes were good. Stage of cancer at diagnosis was associated with systemic metastases.
authors.affiliation: Division of General Surgery, Mayo Clinic, Scottsdale, AZ 85259, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gray
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Pockaj
authors.forename: Miriam L
authors.initials: ML
authors.lastname: Vega
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Connolly
authors.forename: David J
authors.initials: DJ
authors.lastname: DiCaudo
authors.forename: Todd A
authors.initials: TA
authors.lastname: Kile
authors.forename: Edward W
authors.initials: EW
authors.lastname: Buchel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005534:Foot Diseases / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome