title: The proline-rich domain and the microtubule binding domain of protein tau acting as RNA binding domains.
abstract: Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Rd, Chaoyang District, Beijing 100101, China.
authors.forename: XingSheng
authors.initials: X
authors.lastname: Wang
authors.forename: DongLiang
authors.initials: D
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: MeiHua
authors.initials: M
authors.lastname: Qu
authors.forename: XiaoHong
authors.initials: X
authors.lastname: Zhou
authors.forename: HaiJin
authors.initials: H
authors.lastname: He
authors.forename: RongQiao
authors.initials: R
authors.lastname: He
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D011392:Proline / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012313:RNA / Q000378:metabolism*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D016875:tau Proteins; D012313:RNA; D011392:Proline