title: Two-choice reaction time performance in Sprague-Dawley rats exposed to alcohol during adolescence or adulthood.
abstract: Adolescent alcohol abusers display subtle attention impairments. This study used a two-choice reaction time task to examine the effects of ethanol on sustained attention following adult or adolescent exposure. Sprague-Dawley rats were exposed to ethanol vapor for 14 days starting on postnatal day 30 (adolescence) or 60-64 (adulthood) and were then trained to perform the two-choice reaction time task. Ethanol exposure resulted in blood ethanol levels averaging 215 mg/dl. Behavior following adult ethanol exposure was characterized by increased accuracy and omissions during the two-choice reaction time task, reduced fixed ratio lever pressing, and reductions in the highest fixed ratio completed on a progressive ratio schedule. Adolescent ethanol exposure transiently increased two-choice reaction time accuracy and slightly reduced fixed ratio lever presses. Improved accuracy was unexpected, but might be related to ethanol-induced increases in central nervous system arousal and/or mild behavioral perseveration. Increased omissions, reduced lever pressing, and reductions in the highest fixed ratios completed most likely reflect decreased 'motivation to work' and index generalized anhedonia. This study is the first to demonstrate that rats exposed to ethanol during adulthood are more sensitive to the effects of ethanol on sustained attention than rats exposed to ethanol during adolescence and to ethanol-induced anhedonia, as indexed by two-choice reaction time performance.
authors.affiliation: Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California 92037, USA. slobez@scripps.edu
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Slawecki
mesh_terms: D000280:Administration, Inhalation; D000375:Aging / Q000523:psychology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003627:Data Interpretation, Statistical; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects*; D012055:Reinforcement Schedule; D012201:Reward; D013395:Sucrose / Q000494:pharmacology
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol; D013395:Sucrose