title: [Laryngeal cancer in patients younger than 40 years].
abstract: BACKGROUND
  We undertook this study to report demographic data of laryngeal cancer patients <40 years old and treatment results.
  
  
  METHODS
  In a retrolective study we reviewed the clinical records of 500 patients with laryngeal cancer in the period from 1989 to 2004 and included those patients<40 years of age.
  
  
  RESULTS
  We found 15 patients, representing 4.4% of the series. Nine (60%) were men and six (40%) were women, with a 1.5:1 ratio. Average group age was 35 years (range 21-40 and median of 37 months). Average time of evolution at the time of diagnosis was 14.4 months (range 0-36 and median of 12 months); 60% of the patients were smokers and 40% admitted to drinking alcohol; dysphonia was the main symptom found in 87% of the patients. The most frequent location was the glottis in 11 (73%) patients. Well-differentiated tumors represented 53% of the cases. Initial treatment was surgery in four (27%) patients; radiotherapy in five (33%) patients receiving an average of 63.44 Gy; concomitant chemoradiotherapy in one patient (7%) using gemcitabine; four (27%) patients were treated with neoadjuvant chemotherapy followed by radiotherapy; and one patient did not receive treatment. The average time in which the patients relapsed after the first treatment was 19.57 months (range 2-63) and four were classified as persistent. Survival time was 32 months (range 2-106 and median 27 months). Finally, organ preservation rate was obtained in 28.5%.
  
  
  CONCLUSIONS
  Squamous cell carcinoma of the larynx is rare in patients<40 years old in our study. Gender relation seems to be equal, although a slight predominance of men does still exist. Classical risk factors were present in 60% of the cases. Prognosis for these patients was determined by the initial clinical stage.
authors.affiliation: Departamento de Cabeza y Cuello, Instituto Nacional de Cancerología, Av. San Fernando 22, Col. Tlalpan, 14080 México, D.F., Mexico. kuauhyama@starmedia.com
authors.forename: Kuauhyama
authors.initials: K
authors.lastname: Luna-Ortiz
authors.forename: Verónica
authors.initials: V
authors.lastname: Villavicencio-Valencia
authors.forename: Omar J
authors.initials: OJ
authors.lastname: Saucedo-Ramírez
authors.forename: Mario
authors.initials: M
authors.lastname: Rascón-Ortiz
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000628:therapy*; D008297:Male; D012189:Retrospective Studies