Synthesis of the G-C DNA base hybrid with a functional tail.
Molecules which possess the hydrogen bonding codes of both guanine and cytosine ("G-C DNA base hybrids") are known to organize in a hexagonal array both in solution and the solid state. Including an easily derivatizable functional group in the molecule allows the co-organization of virtually any species in the hexagonal periphery. Simple 5- and 6-step procedures are described for the synthesis of DNA base hybrids with tail groups which are terminated by electrophilic (primary bromide) and nucleophilic (primary alcohol) functions, respectively.
Mascal
Mark
M
Department of Chemistry, University of California Davis, Davis, California 95616, USA. mascal@chem.ucdavis.edu
Farmer
Steven C
SC
Arnall-Culliford
James R
JR
D003596:Cytosine / Q000138:chemical synthesis*; D006147:Guanine
D006147:Guanine; D003596:Cytosine