Radical trifluoromethylation of ketone silyl enol ethers by activation with dialkylzinc.
[reaction: see text] The radical trifluoromethylation of ketone silyl enol ethers gave alpha-CF(3) ketones in good yields with wide scope of the ketonic substrates including acyclic ketones and cyclopentanone. The use of dialkylzinc to activate the silyl enol ethers is the key to the efficient radical trifluoromethylation.
Mikami
Koichi
K
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan. kmikami@o.cc.titech.ac.jp
Tomita
Yuichi
Y
Ichikawa
Yoshiyuki
Y
Amikura
Kazutoshi
K
Itoh
Yoshimitsu
Y