title: Rippled-pattern sebaceoma: a report of a lesion on the back with a review of the literature.
abstract: A 68-year-old Japanese man presented with a nodule that had been present for 5 to 6 years on the right side of the back. Physical examination revealed a dome-shaped, 12 x 13-mm, dark red nodule. It was excised with a 2 to 3-mm margin. The patient remained free of disease during 77 months of follow-up. Microscopic examination revealed a bulb-like tumor in the dermis, contiguous with the overlying epidermis. It was composed of small, monomorphous, cigar-shaped basaloid cells in linear, parallel rows, resembling the palisading of nuclei of Verocay bodies, and presenting a rippled-pattern. There were scattered cells showing sebaceous differentiation with vacuolated cytoplasm and scalloped nuclei. There were tiny, duct-like spaces. The tumor revealed characteristics of rippled-pattern sebaceoma. The present case is the first reported rippled-pattern sebaceous neoplasm on the back. Many spindle cell tumors, such as basal cell carcinoma, pleomorphic adenoma, dermatofibrosarcoma protuberans, myofibroblastoma, and leiomyoblastoma, in addition to trichoblastoma and sebaceoma, can have a rippled-pattern.
authors.affiliation: Department of Dermatology, University of Fukui, Fukui, Japan. kiyo@fmrsrsa.fukui-med.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kiyohara
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kumakiri
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kuwahara
authors.forename: Atsuko
authors.initials: A
authors.lastname: Saitoh
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ansai
mesh_terms: D000368:Aged; D001415:Back; D014408:Biomarkers, Tumor / Q000032:analysis; D005500:Follow-Up Studies; D018859:Hair Follicle / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D018295:Neoplasms, Basal Cell / Q000737:chemistry / Q000473:pathology*; D012626:Sebaceous Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D007633:Keratins