Reduction of Cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells.
Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosides (RGUG). In our previous studies, this new processed ginseng reduced cisplatin-induced nephrotoxicity more than white ginseng in both in vitro and in vivo systems. In this study, we isolated and characterized active principles through activity-guided fractionation. Ginsenosides Rh4 and Rk3 significantly reduced the cisplatin-induced nephrotoxicity in LLC-PK1 cells in a dose-dependent manner. The mechanisms of function and structure-activity relationships with other ginsenosides remain for further investigation.
Baek
Seung Hoon
SH
Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University, Seoul, Korea.
Piao
Xiang Lan
XL
Lee
Un Jo
UJ
Kim
Hyun Young
HY
Park
Jeong Hill
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology; D002945:Cisplatin / Q000633:toxicity*; D019610:Cytoprotection; D004305:Dose-Response Relationship, Drug; D036145:Ginsenosides / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D018374:LLC-PK1 Cells; D005894:Panax / Q000737:chemistry*; D013552:Swine
D000970:Antineoplastic Agents; D000975:Antioxidants; D036145:Ginsenosides; D002945:Cisplatin