Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice.
Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity.
Ohnishi
Ryoko
R
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.
Ito
Hideyuki
H
Iguchi
Ayumu
A
Shinomiya
Kazuaki
K
Kamei
Chiaki
C
Hatano
Tsutomu
T
Yoshida
Takashi
T
D000818:Animals; D002109:Caffeic Acids / Q000032:analysis / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000378:metabolism / Q000494:pharmacology; D002726:Chlorogenic Acid / Q000378:metabolism* / Q000494:pharmacology* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000032:analysis / Q000494:pharmacology; D005243:Feces; D005419:Flavonoids; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D010636:Phenols; D059808:Polyphenols; D051381:Rats
D002109:Caffeic Acids; D000697:Central Nervous System Stimulants; D003373:Coumaric Acids; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D002726:Chlorogenic Acid; C040048:caffeic acid