title: Use of a modified-live vaccine to prevent persistent testicular infection with bovine viral diarrhea virus.
abstract: A commercial vaccine containing modified-live bovine viral diarrhea virus (BVDV; types 1 and 2) was administered to one group of 22 peripubertal bulls 28 days before intranasal inoculation with a type 1 strain of BVDV. A second group of 23 peripubertal bulls did not receive the modified-live BVDV vaccine before intranasal inoculation. Ten of 23 unvaccinated bulls--but none of the vaccinated bulls--developed a persistent testicular infection as determined by immunohistochemistry and polymerase chain reaction. Results of this study indicate that administration of a modified-live vaccine containing BVDV can prevent persistent testicular infection if peripubertal bulls are vaccinated before viral exposure.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
authors.forename: M Daniel
authors.initials: MD
authors.lastname: Givens
authors.forename: Kay P
authors.initials: KP
authors.lastname: Riddell
authors.forename: Yijing
authors.initials: Y
authors.lastname: Zhang
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Galik
authors.forename: David A
authors.initials: DA
authors.lastname: Stringfellow
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Brodersen
authors.forename: James A
authors.initials: JA
authors.lastname: Jackson
authors.forename: Michael A
authors.initials: MA
authors.lastname: Ellsworth
authors.forename: Martin D
authors.initials: MD
authors.lastname: Ficken
authors.forename: Robert L
authors.initials: RL
authors.lastname: Carson
authors.forename: James G W
authors.initials: JG
authors.lastname: Wenzel
authors.forename: M Shonda
authors.initials: MS
authors.lastname: Marley
mesh_terms: D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D002417:Cattle; D030241:Diarrhea Virus 1, Bovine Viral / Q000276:immunology* / Q000302:isolation & purification; D030242:Diarrhea Virus 2, Bovine Viral / Q000276:immunology* / Q000302:isolation & purification; D018562:Disease Transmission, Infectious / Q000517:prevention & control / Q000662:veterinary*; D007150:Immunohistochemistry / Q000379:methods / Q000662:veterinary; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods / Q000662:veterinary; D011897:Random Allocation; D012661:Semen / Q000821:virology; D013733:Testicular Diseases / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D013737:Testis / Q000821:virology; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D017201:Virus Shedding
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines