title: Ibandronate for the treatment of hypercalcemia or nephrocalcinosis in patients with multiple myeloma and acute renal failure: Case reports.
abstract: Multiple myeloma disrupts calcium homeostasis by a variety of mechanisms, including bone destruction and resorption. This causes hypercalcemia. When left untreated, hypercalcemia leads to nephrocalcinosis, impairment of kidney function, and eventually renal failure. Some degree of renal dysfunction is common in myeloma patients. Here, we report case studies showing the efficacy and renal safety of the single-nitrogen bisphosphonate, ibandronate, for the treatment of hypercalcemia and/or nephrocalcinosis in multiple myeloma patients hospitalized with acute renal failure. Patients (n = 7) received either one or two intravenous infusions of ibandronate (2-6 mg). Ibandronate was well tolerated in all patients and returned elevated blood calcium levels to normal. Renal function improved for all patients and normalized in 3/7 patients. We conclude that ibandronate is involved in rapidly improving or restoring acute renal function and calcium levels to within the normal range in this patient population. To clarify the exact value of ibandronate, further investigation is warranted in randomized prospective trials.
authors.affiliation: Medizinische Klinik A, Klinikum Ludwigshafen, Ludwigshafen, Germany. HenrichDM@aol.com
authors.forename: Dirk
authors.initials: D
authors.lastname: Henrich
authors.forename: Martin
authors.initials: M
authors.lastname: Hoffmann
authors.forename: Michael
authors.initials: M
authors.lastname: Uppenkamp
authors.forename: Raoul
authors.initials: R
authors.lastname: Bergner
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications*; D000368:Aged; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy*; D000077557:Ibandronic Acid; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D009397:Nephrocalcinosis / Q000188:drug therapy*
chemical_list: D004164:Diphosphonates; D003404:Creatinine; D002118:Calcium; D000077557:Ibandronic Acid