A new cyclotetrapeptide from marine fungus Trichoderma reesei.
A new cyclotetrapeptide, trichoderide A, was isolated from the marine fungus Trichoderma reesei. The structure was identified by spectral methods, and the stereochemical assignments were made by chiral HPLC of the hydrolyzed compound. Trichoderide A showed moderate cytotoxity against human A375-S2 melanoma cell line.
Sun
Yi
Y
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, PR China.
Tian
Li
L
Huang
Yong-Fu
YF
Sha
Yi
Y
Pei
Yue-Hu
YH
D000596:Amino Acids / Q000032:analysis; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental / Q000188:drug therapy; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles; D014242:Trichoderma / Q000737:chemistry*
D000596:Amino Acids; D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; D013778:Tetrazolium Salts; D013844:Thiazoles; C514447:trichoderide A; C022616:thiazolyl blue