Changes in periodontal and rheumatological conditions after 2 years in patients with juvenile idiopathic arthritis.
BACKGROUND
The aim of this study was to monitor changes in periodontal inflammation in patients with juvenile idiopathic arthritis (JIA) for 2 years. We investigated the influence of rheumatic disease activity and antirheumatic medication on clinical and immunological parameters of periodontal inflammation in these individuals.


METHODS
Two years after a baseline examination, the periodontal and rheumatological conditions of 18 adolescents with JIA and 14 control subjects were described. The clinical periodontal inflammation was monitored by registration of visual plaque, marginal bleeding, probing depth, and clinical attachment loss (AL). Periodontal inflammation was also assessed by analysis of the cytokines interleukin (IL)-1beta and IL-18 and the collagenase matrix metalloproteinase (MMP)-8 by enzyme-linked immunosorbent assay.


RESULTS
The erythrocyte sedimentation rate and clinical rheumatological parameters were significantly improved at the 2-year follow-up. The number of sites with plaque decreased, and the number of pockets >/=4 mm increased, whereas bleeding levels and the extension of AL remained unchanged. IL-1beta in gingival crevicular fluid decreased significantly in the JIA group after 2 years. No differences were observed for IL-1beta, MMP-8, or IL-18 levels between groups after 2 years.


CONCLUSIONS
Two years after the baseline examination, no clinical or laboratory differences in periodontal inflammation could be found between JIA patients and control subjects.
Miranda
Letícia A
LA
Institute of Odontology, Division of Periodontology, Karolinska Institute, Huddinge, Sweden. leticia.miranda@ki.se
Braga
Flavia
F
Fischer
Ricardo G
RG
Sztajnbok
Flávio R
FR
Figueredo
Carlos Marcelo S
CM
Gustafsson
Anders
A
D000293:Adolescent; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis; D001799:Blood Sedimentation; D003773:Dental Plaque / Q000145:classification; D005260:Female; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D005884:Gingival Hemorrhage / Q000145:classification; D006801:Humans; D020382:Interleukin-18 / Q000032:analysis; D053583:Interleukin-1beta / Q000032:analysis; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000032:analysis; D017622:Periodontal Attachment Loss / Q000145:classification; D010514:Periodontal Pocket / Q000145:classification; D010518:Periodontitis / Q000145:classification / Q000276:immunology / Q000503:physiopathology*
D018501:Antirheumatic Agents; D015415:Biomarkers; D020382:Interleukin-18; D053583:Interleukin-1beta; D020784:Matrix Metalloproteinase 8