New benzoyl urea derivatives as novel NR2B selective NMDA receptor antagonists.
A novel series of benzoyl urea derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substitution of the piperidine ring on the biological activity of the compounds was studied. Compound 9 was active in the formalin test in mice.
Borza
I
I
Gedeon Richter Ltd, Budapest, Hungary. i.borza@richter.hu
Greiner
I
I
Kolok
S
S
Galgóczy
K
K
Ignácz-Szendrei
Gy
G
Horváth
Cs
C
Farkas
S
S
Gáti
T
T
Háda
V
V
Domány
Gy
G
D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005470:Fluorometry; D005557:Formaldehyde; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010147:Pain Measurement / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013055:Spectrophotometry, Infrared; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*
D001565:Benzoates; D007202:Indicators and Reagents; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate; D005557:Formaldehyde; D014508:Urea