[Relations between VDR3 and COL1A1 genes and markers of bone tissue metabolism in patients with chronic obstructive pulmonary disease].
OBJECTIVE
To study correlation between polymorphism of the genes of vitamin D3 (VDR3), collagen of type 1 alpha-1 (COL1A1) and markers of bone tissue metabolism in chronic obstructive pulmonary disease


METHODS
A total of 56 COPD patients were examined. Bone metabolism was evaluated by osteocalcin (OC) level and betaCL in the blood; BsmI polymorphism of gene VDR3 (genotypes BB, Bb, bb) and Sp1 polymorphism of gene COL1A1 (genotypes SS, Ss, ss)--by polymerase chain reaction. The control group consisted of 50 healthy persons of matched gender and age.


RESULTS
OC and S allele were not the same in genotypes BB, Bb and bb. Ss and ss genotypes carriers had higher beta CL level than SS-carriers. SS and ss genotypes carriers did not differ with betaCL concentrations (p > 0.05).


CONCLUSIONS
Testing of VDR3 and COL1A1 genes gives grounds for detection of predisposition to development of pulmonogenic osteopenic syndrome.
Gel'tser
B I
BI
Kochetkova
E A
EA
Grigor'eva
O Iu
OIu
Al'bavichus
S A
SA
Bubnov
O Iu
OIu
D015415:Biomarkers / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000235:genetics*; D001842:Bone and Bones / Q000378:metabolism*; D016022:Case-Control Studies; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics*
D015415:Biomarkers; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D018167:Receptors, Calcitriol; D015675:Osteocalcin