title: Bilateral ischemic optic neuropathy after transurethral prostatic resection: a case report.
abstract: BACKGROUND
  Nonarteritic ischemic optic neuropathy affects the anterior portion of the optic nerve and is characterized by sudden, painless visual loss. The affected eye has a relative afferent pupillary defect. The typical funduscopic appearance includes optic disc edema, with associated nerve fiber layer hemorrhage. Risk factors include advanced age, systemic hypertension, nocturnal hypotension, diabetes mellitus, and a small cup-to-disc ratio. Bilateral presentation is rare. Postoperative optic neuropathy has been associated with nonocular surgery; risk factors include a combination of prolonged surgical times, acute systemic hypotension, anemia due to blood loss, or prone positioning. We report for the first time a patient with bilateral, simultaneous anterior ischemic optic neuropathy after elective transurethral prostatic resection.
  
  
  METHODS
  A 66-year old man underwent surgery for benign prostatic hyperplasia. The preoperative blood pressure was 140/85 mmHg, hemoglobin 15.9 g/dL, and hematocrit 48.6%. Two hours postoperatively, the blood pressure, hemoglobin, and hematocrit dropped dramatically. One day later, transient horizontal diplopia developed. Funduscopy showed a congenitally small cup-to-disc ratio without papillary edema. Other ocular findings were unremarkable. By 4 days postoperatively, sudden and painless amaurosis bilaterally developed when the patient awoke with nausea and vomiting. Visual acuity was no light perception bilaterally. The optic discs were swollen with small hemorrhages. Scans of the head and orbits and electrolyte levels were normal. There were no responses on visual evoked potentials bilaterally. The blood pressure was 90/50 mm Hg, the hemoglobin 7.0 g/dL, and the hematocrit 22.9%, necessitating infusion of three units of packed red blood cells. The blood pressure, hematocrit, and hemoglobin increased to normal levels. Three months later the visual acuity remained no light perception. The pupils were unreactive and there was marked optic disc atrophy bilaterally.
  
  
  CONCLUSIONS
  Bilateral and simultaneous acute ischemic optic neuropathy may be a rare but devastating surgical complication. The combination of anemia and hypotension may increase the risk of anterior ischemic optic neuropathy postoperatively after transurethral prostatic resection.
authors.affiliation: Ophthalmology Department, Clínica Universitaria de Navarra, Universidad de Navarra, Pamplona (Navarra), Spain. lmsadaba@unav.es
authors.forename: Luis M
authors.initials: LM
authors.lastname: Sadaba
authors.forename: Alfredo
authors.initials: A
authors.lastname: Garcia-Layana
authors.forename: Miguel J
authors.initials: MJ
authors.lastname: Maldonado
authors.forename: Jose M
authors.initials: JM
authors.lastname: Berian
mesh_terms: D000368:Aged; D000740:Anemia / Q000209:etiology; D001766:Blindness / Q000209:etiology; D004172:Diplopia / Q000209:etiology; D006400:Hematocrit; D006801:Humans; D007022:Hypotension / Q000209:etiology; D008297:Male; D018917:Optic Neuropathy, Ischemic / Q000097:blood / Q000209:etiology*; D011184:Postoperative Period; D011470:Prostatic Hyperplasia / Q000601:surgery*; D020728:Transurethral Resection of Prostate / Q000009:adverse effects*