A possible link between prenatal exposure to famine and breast cancer: a preliminary study.
In a study of 475 women born around the 1944-1945 Dutch famine, women exposed to prenatal famine more often reported a history of breast cancer than nonexposed women (hazard ratio, 2.6; 95% confidence interval, 0.9-7.7). They also had alterations in reproductive risk factors. Prenatal famine may increase breast cancer incidence.
Painter
R C
RC
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
De Rooij
S R
SR
Bossuyt
P M M
PM
Osmond
C
C
Barker
D J P
DJ
Bleker
O P
OP
Roseboom
T J
TJ
D001724:Birth Weight; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D039382:Maternal Nutritional Physiological Phenomena; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D016016:Proportional Hazards Models; D013217:Starvation / Q000503:physiopathology*; D047789:World War II