Cargo takes control of endocytosis.
Clathrin-mediated endocytosis is a major route for diverse cargo to enter the cellular endocytic pathway. New findings by Puthenveedu and von Zastrow (2006) suggest that certain cargo proteins, such as G protein coupled receptors that bind to PDZ domains, regulate their own targeting to a subset of clathrin-coated pits. Thus, cargo proteins may cause functional specialization of vesicle trafficking within the early endocytic pathway.
Haucke
Volker
V
Institute of Chemistry and Biochemistry, Laboratory of Membrane Biochemistry, Freie Universität Berlin, Takustrasse 6, 14195 Berlin, Germany. vhaucke@chemie.fu-berlin.de
D000199:Actins / Q000378:metabolism; D000818:Animals; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D022161:Transport Vesicles / Q000737:chemistry / Q000378:metabolism
D000199:Actins; D002966:Clathrin; D008869:Microtubule-Associated Proteins; D043562:Receptors, G-Protein-Coupled