An Asian patient with intraocular lymphoma treated by intravitreal methotrexate.
BACKGROUND
To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma.


METHODS
A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma.


METHODS
The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up.


CONCLUSIONS
Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma.
Wang
Jia-Kang
JK
Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Yang
Chung-May
CM
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Lin
Chang-Ping
CP
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. cpilin@ms7.hinet.net.
Shan
Yin-Dong
YD
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Lo
Andy Y
AY
Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Tien
Hwei-Fang
HF
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007267:Injections; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D013624:Taiwan; D014822:Vitreous Body
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate