title: Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology.
abstract: Lovastatin, an inhibitor of HMG-CoA reductase, was produced by submerged fermentation using Monascus purpureus MTCC 369. Five nutritional parameters screened using Plackett-Burman experimental design were optimized by Box-Behnken factorial design of response surface methodology for lovastatin production in shake flask cultures. Maximum lovastatin production of 351 mg/l were predicted in medium containing 29.59 g/l dextrose, 3.86 g/l NH4Cl, 1.73 g/l KH2PO4, 0.86 g/l MgSO4 x 7H2O, and 0.19 g/l MnSO4 x H2O using response surface plots and point prediction tool of DESIGN EXPERT 7.0 (Statease, USA) software.
authors.affiliation: Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
authors.forename: Sadik Ali
authors.initials: SA
authors.lastname: Sayyad
authors.forename: Bibhu Prasad
authors.initials: BP
authors.lastname: Panda
authors.forename: Saleem
authors.initials: S
authors.lastname: Javed
authors.forename: Mohd
authors.initials: M
authors.lastname: Ali
mesh_terms: D003470:Culture Media / Q000737:chemistry; D005285:Fermentation; D008148:Lovastatin / Q000096:biosynthesis*; D032741:Monascus / Q000378:metabolism*
chemical_list: D003470:Culture Media; D008148:Lovastatin