Critical appraisal of the current practice in murine TNBS-induced colitis.
There is no standard practice in the induction of colitis by 2,4,6-trinitrobenzene sulfonic acid. In this review the current practice in 2,4,6-trinitrobenzene sulfonic acid colitis is studied using 20 recently published articles. We compare the different protocols, discuss the mechanism of disease and give recommendations for the future use of the model.
te Velde
Anje A
AA
Centre for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. a.a.tevelde@amc.uva.nl
Verstege
Marleen I
MI
Hommes
Daniel W
DW
D000818:Animals; D003092:Colitis / Q000139:chemically induced*; D004195:Disease Models, Animal; D004342:Drug Hypersensitivity; D020869:Gene Expression Profiling / Q000379:methods; D006287:Health Planning Guidelines; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D014302:Trinitrobenzenesulfonic Acid
D014302:Trinitrobenzenesulfonic Acid