Human artificial chromosomes: potential applications and clinical considerations.
Human artificial chromosomes demonstrate promise as a novel class of nonintegrative gene therapy vectors. The authors outline current developments in human artificial chromosome technology and examine their potential for clinical application.
Basu
Joydeep
J
Institute for Genome Sciences & Policy, Duke University, 101 Science Drive, Durham, NC 27708, USA. basu0005@mc.duke.edu
Willard
Huntington F
HF
D022222:Chromosomes, Artificial, Human; D015870:Gene Expression; D018014:Gene Transfer Techniques; D005818:Genetic Engineering; D005819:Genetic Markers; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans
D005819:Genetic Markers