title: Characterization of HLA-B*5516, -B*1313, -B*9512, and -DRB1*1457 alleles identified in a southwest Chinese population.
abstract: The human leukocyte antigen (HLA)-B*5516 allele differs from the B*5502 by a single 97 T --> C substitution (His to Tyr at position 33) in exon 2. The B*1313 allele results from 419 T --> A and 420 A --> C substitutions, encoding a Leu to Tyr substitution at 140 in exon 2 of the B*1301 allele. The B*9512 allele differs from B*1502 by a single 360 G --> C substitution (Gln to His at 120) in exon 3. The DRB1*1457 allele appears to be a hybrid molecule generated by recombination between the DRB1*13 and DRB1*14 alleles. The serological equivalents of these new alleles are HLA-B22, -B13, -B15, and DR13, respectively. Family studies detected two rare haplotypes: A*11, B*9512, DRB1*14 and A*24, B*52, Cw*07, DRB1*1457, DRB3*020201, DQB1*050301. The gene frequencies of these alleles in the Chinese population are less than 0.0001.
authors.affiliation: Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China. xiet@mail.sc.cninfo.net
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Zou
authors.forename: X H
authors.initials: XH
authors.lastname: Xu
authors.forename: M
authors.initials: M
authors.lastname: Luo
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zuo
authors.forename: Y H
authors.initials: YH
authors.lastname: Chen
authors.forename: X H
authors.initials: XH
authors.lastname: Chen
authors.forename: X L
authors.initials: XL
authors.lastname: Chen
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Yao
authors.forename: N
authors.initials: N
authors.lastname: Song
authors.forename: J
authors.initials: J
authors.lastname: Zeng
authors.forename: X Y
authors.initials: XY
authors.lastname: Mi
authors.forename: S X
authors.initials: SX
authors.lastname: Sun
authors.forename: J X
authors.initials: JX
authors.lastname: Wang
authors.forename: T M
authors.initials: TM
authors.lastname: Zhao
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000906:Antibodies / Q000097:blood; D000918:Antibody Specificity / Q000235:genetics; D044466:Asian People / Q000235:genetics; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D005838:Genotype; D015235:HLA-B Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D000906:Antibodies; D000939:Epitopes; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains