title: Gastrointestinal tract involvement in Langerhans cell histiocytosis: case report and literature review.
abstract: Digestive tract involvement in Langerhans cell histiocytosis is exceedingly rare. We report a case of Langerhans cell histiocytosis in an otherwise thriving neonate presenting with hematochezia, anemia, and rash. We also review the few cases of Langerhans cell histiocytosis with gastrointestinal involvement reported in the English-language medical literature. Although gastrointestinal involvement can range in severity from mild to life-threatening, its presence may be indicative of multisystemic disease, and aggressive treatment should be considered.
authors.affiliation: Children's Hospital Boston, Division of Gastroenterology and Nutrition, 300 Longwood Ave, Boston, MA 02115, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hait
authors.forename: Marilyn
authors.initials: M
authors.lastname: Liang
authors.forename: Barbara
authors.initials: B
authors.lastname: Degar
authors.forename: Jonathan
authors.initials: J
authors.lastname: Glickman
authors.forename: Victor L
authors.initials: VL
authors.lastname: Fox
mesh_terms: D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications*; D006801:Humans; D007223:Infant