Scleroderma renal crisis in a patient with anticentromere antibody-positive limited cutaneous systemic sclerosis.
We have encountered a 68-year-old Japanese woman with limited cutaneous systemic sclerosis who developed de novo onset of accelerated hypertension and renal dysfunction; thus we diagnosed scleroderma renal crisis. Anticentromere antibody alone was identified, and not anti-DNA topoisomerase I antibody, anti-RNA polymerase antibodies, anti-Th/To antibodies, or antiribonucleoprotein antibodies, even with use of immunoprecipitation assay. She was successfully treated with angiotensin-converting enzyme inhibitor. This case, scleroderma renal crisis with detection of anticentromere antibody, is thought to be extremely uncommon.
Sugimoto
Toshiro
T
Department of Medicine, Shiga University of Medical Science, Seta, Otsu, 520-2192, Japan. toshiro@belle.shiga-med.ac.jp
Soumura
Mariko
M
Danno
Kiichiro
K
Kaji
Kenzo
K
Kondo
Miki
M
Hirata
Kunio
K
Nakazawa
Jun
J
Uzu
Takashi
T
Nishio
Yoshihiko
Y
Kashiwagi
Atsunori
A
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D002503:Centromere / Q000276:immunology*; D004942:Esophagitis, Peptic / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology*; D008105:Liver Cirrhosis, Biliary / Q000150:complications; D011537:Pruritus / Q000150:complications; D011928:Raynaud Disease / Q000150:complications; D045745:Scleroderma, Limited / Q000150:complications* / Q000276:immunology / Q000503:physiopathology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D001323:Autoantibodies; D001324:Autoantigens