2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57BL/6 mice.
Acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of Leishmania major-infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to L. major in the face of immune suppression.
Bowers
Owen J
OJ
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80126, USA. owen.bowers@uchsc.edu
Sommersted
Kirsa B
KB
Sowell
Ryan T
RT
Boling
Gretchen E
GE
Hanneman
William H
WH
Titus
Richard G
RG
Dekrey
Gregory K
GK
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D018320:Leishmania major / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000469:parasitology*; D051379:Mice; D008810:Mice, Inbred C57BL; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*
D000913:Antibodies, Protozoan; D016207:Cytokines; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins