title: Seasonal variation in blood pressure of patients on continuous ambulatory peritoneal dialysis.
abstract: BACKGROUND
  A seasonal variation in blood pressure (BP) has been observed in hemodialysis and renal transplant patients. However, this phenomenon in continuous ambulatory peritoneal dialysis (CAPD) patients, whose hemodynamics are different from hemodialysis patients, has not been reported before. In addition, the contribution of extracellular water (ECW) in the seasonal variation in BP is not clear.
  
  
  METHODS
  All stable CAPD patients (n = 122) dialyzed in a single center from January 1, 2003 to December 12, 2004 were studied. Systolic blood pressure (SBP), diastolic blood pressure (DBP), weight and ECW (by bioimpedance analysis) were measured in every patient. Climatic data were obtained from the Beijing Weather Bureau. These data were pooled together and grouped according to the calendar month.
  
  
  RESULTS
  In general, an apparent seasonal variation in BP was observed in CAPD patients. BP began to decrease from spring and reached the lowest level in summer, then increased from autumn and reached its peak in winter. The seasonal variation in BP in male patients was similar to that in female patients, but in comparison to non-diabetic patients there was no apparent seasonal variation in the BP of diabetic patients. SBP and DBP negatively correlated with the average atmospheric temperature (r = -0.768, p < 0.001 and r = -0.764, p < 0.001, respectively). BP also negatively correlated with rainfall and humidity, but this correlation disappeared when temperature was controlled in partial correlation analysis. Weight and ECW fluctuated throughout the year but showed no seasonal variation.
  
  
  CONCLUSIONS
  On the whole there was an apparent seasonal variation in blood pressure in CAPD patients. As opposed to non-diabetic patients, there was no apparent seasonal variation in BP in diabetic patients. The seasonal variation in BP was influenced more by temperature than rainfall and humidity, and the change in ECW was not seasonal, suggesting that other mechanisms such as total peripheral resistance might play a more important role in this phenomenon.
authors.affiliation: Division of Nephrology, First Hospital, Peking University, Beijing, China.
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Cheng
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Jiang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Tang
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005921:Glomerulonephritis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D006813:Humidity; D006973:Hypertension / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000503:physiopathology* / Q000628:therapy; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012189:Retrospective Studies; D012621:Seasons