The lymphotoxin Cys13Arg polymorphism and cognitive functioning in individuals with schizophrenia.
Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a significant association between cognitive functioning and the LTA Cys13Arg polymorphism within the schizophrenia (p<0.008) but not the other diagnostic groups. There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia.
Dickerson
Faith
F
Stanley Research Center at Sheppard Pratt, Sheppard Pratt, 6501 North Charles St., Baltimore, MD 21204, USA. fdickerson@sheppardpratt.org
Boronow
John
J
Stallings
Cassie
C
Origoni
Andrea
A
Yolken
Robert
R
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001120:Arginine / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics* / Q000276:immunology; D003072:Cognition Disorders / Q000235:genetics* / Q000276:immunology; D003545:Cysteine / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D018259:Herpesvirus 1, Human / Q000276:immunology; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics* / Q000276:immunology
D000914:Antibodies, Viral; D008233:Lymphotoxin-alpha; D001120:Arginine; D003545:Cysteine