CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.
Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.
Caccamo
Nadia
N
Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy.
Battistini
Luca
L
Bonneville
Marc
M
Poccia
Fabrizio
F
Fournié
Jean Jacques
JJ
Meraviglia
Serena
S
Borsellino
Giovanna
G
Kroczek
Richard A
RA
La Mendola
Carmela
C
Scotet
Emmanuel
E
Dieli
Francesco
F
Salerno
Alfredo
A
D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte; D001402:B-Lymphocytes / Q000276:immunology*; D023201:CD40 Ligand; D002450:Cell Communication / Q000276:immunology; D005260:Female; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D060889:Inducible T-Cell Co-Stimulator Protein; D016753:Interleukin-10 / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine / Q000032:analysis*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism
D000945:Antigens, Differentiation, T-Lymphocyte; C095085:CXCR5 protein, human; C556692:ICOS protein, human; D060889:Inducible T-Cell Co-Stimulator Protein; D016692:Receptors, Antigen, T-Cell, gamma-delta; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D016753:Interleukin-10; D023201:CD40 Ligand; D015847:Interleukin-4