Subversion of innate and adaptive immune responses by Toxoplasma gondii.
The intracellular apicomplexan parasite Toxoplasma gondii is able to survive and persist in immunocompetent intermediate hosts for the host's life span. This is despite the induction of a vigorous humoral and -- more importantly -- cell-mediated immune response during infection. In order to establish and maintain such chronic infections, however, T. gondii has evolved multiple strategies to avoid or to interfere with potentially efficient anti-parasitic immune responses of the host. Such immune evasion includes (1) indirect mechanisms by altering the expression and secretion of immunomodulatory cytokines or by altering the viability of immune cells and (2) direct mechanisms by establishing a lifestyle within a suitable intracellular niche and by interference with intracellular signaling cascades, thereby abolishing a number of antimicrobial effector mechanisms of the host. Despite the parasite's ability to interfere successfully with the host's efforts to eradicate the infection, the immune response is, however, not completely abrogated but is rather partially diminished after infection. T. gondii thus keeps a delicate balance between induction and suppression of the host's immune response in order to guarantee the survival of the host as a safe harbor for parasite development and to allow its transmission to the definitive host.
Lang
Christine
C
Institute for Medical Microbiology, Georg-August-University, Kreuzbergring 57, Göttingen, Germany.
Gross
Uwe
U
Lüder
Carsten G K
CG
D000818:Animals; D016207:Cytokines; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D014122:Toxoplasma / Q000502:physiology*; D014123:Toxoplasmosis / Q000276:immunology*
D016207:Cytokines