title: Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities.
abstract: We report here that phenol derivatives with two and four quaternary ammoniums were synthesized and their abilities to bind and cross-link DNA were investigated. Thermal denaturizing studies indicated that derivatives possess similar DNA binding abilities and gel electrophoresis revealed that more charges (series B) and electronic donation substitute linkers (like -S-) dramatically increase the DNA cross-linking abilities.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Hanping
authors.initials: H
authors.lastname: He
authors.forename: Wulue
authors.initials: W
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Cao
authors.forename: Xiao-Lian
authors.initials: XL
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
mesh_terms: D003432:Cross-Linking Reagents; D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D019800:Phenol; D000644:Quaternary Ammonium Compounds
chemical_list: D003432:Cross-Linking Reagents; D000644:Quaternary Ammonium Compounds; D019800:Phenol; D004247:DNA