title: 2,6-Quinolinyl derivatives as potent VLA-4 antagonists.
abstract: A new series of 2,6-quinolinyl derivatives was prepared leading to potent low nanomolar VLA-4/VCAM-1 antagonists.
authors.affiliation: UCB S.A., R&D, Chemin du Foriest, B-1420 Braine-l'Alleud, Belgium.
authors.forename: Marie-Agnès
authors.initials: MA
authors.lastname: Lassoie
authors.forename: Fabienne
authors.initials: F
authors.lastname: Broeders
authors.forename: Philippe
authors.initials: P
authors.lastname: Collart
authors.forename: Laurent
authors.initials: L
authors.lastname: Defrère
authors.forename: Françoise
authors.initials: F
authors.lastname: de Laveleye-Defais
authors.forename: Thierry
authors.initials: T
authors.lastname: Demaude
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Gassama
authors.forename: Gérald
authors.initials: G
authors.lastname: Guillaumet
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Hayez
authors.forename: Laszlo
authors.initials: L
authors.lastname: Kiss
authors.forename: Laurent
authors.initials: L
authors.lastname: Knerr
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Nicolas
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Norsikian
authors.forename: Luc
authors.initials: L
authors.lastname: Quéré
authors.forename: Sylvain
authors.initials: S
authors.lastname: Routier
authors.forename: Valérie
authors.initials: V
authors.lastname: Verbois
authors.forename: Laurent
authors.initials: L
authors.lastname: Provins
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors*; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D039041:Integrin alpha4beta1; D011804:Quinolines