JAK2V617F mutations as cooperative genetic lesions in t(8;21)-positive acute myeloid leukemia.
Significant progress has been made in identifying genetic lesions that are causally implicated in the pathogenesis of acute myeloid leukemia (AML). These insights improve our understanding of the genetic basis of the disease, a prerequisite for the development of novel therapeutic approaches.
Döhner
Konstanze
K
Du
Juan
J
Corbacioglu
Andrea
A
Scholl
Claudia
C
Schlenk
Richard F
RF
Döhner
Hartmut
H
D019943:Amino Acid Substitution / Q000235:genetics*; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009154:Mutation
C507924:JAK2 protein, human; D053614:Janus Kinase 2