Nanostructured thermosensitive polymers with radical scavenging ability.
The thermosensitive [60]fullerene end-capped poly(N-isopropylacrylamide) was successfully synthesized by the reaction of C(60) with dithiobenzoate-terminated poly(N-isopropylacrylamide), which was prepared by reversible addition-fragmentation chain-transfer (RAFT) polymerization in the presence of azobisisobutyronitrile (AIBN). Its structure was determined by FTIR, UV/Vis, and carbon and proton NMR spectroscopy as well as by size exclusion chromatography (SEC). The novel fullerenated polymer retained the thermosensitivity of poly(N-isopropylacrylamide). Moreover, it is soluble in water and most of the common organic solvents. Interestingly, it was able to form nanoparticle clusters in methanol and exhibited significant radical scavenging ability in cell viability and metabolic activity tests with fibroblasts and NOR-3 radicals.
Zhou
Guangchang
G
Department of Chemistry, Clark Atlanta University, 223 James P. Brawley DR SW, Atlanta, GA 30314, USA.
Harruna
Issifu I
II
Zhou
Weilie L
WL
Aicher
Wilhelm K
WK
Geckeler
Kurt E
KE
D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002850:Chromatography, Gel; D005347:Fibroblasts / Q000187:drug effects; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D037741:Fullerenes / Q000737:chemistry; D051379:Mice; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009570:Nitriles / Q000737:chemistry; D009574:Nitro Compounds / Q000494:pharmacology; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared
D000180:Acrylic Resins; D016166:Free Radical Scavengers; D037741:Fullerenes; D020030:Nitric Oxide Donors; D009570:Nitriles; D009574:Nitro Compounds; D011108:Polymers; C052970:poly-N-isopropylacrylamide; C061872:FK 409; C004526:azobis(isobutyronitrile); C069837:fullerene C60