Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal disease.
Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO.
Skaleric
Uros
U
Department of Oral Medicine & Periodontology, Faculty of Medicine, Hrvatski trg 6, 1000 Ljubljana, Slovenia. uros.skaleric@mf.uni-lj.si
Gaspirc
Boris
B
McCartney-Francis
Nancy
N
Masera
Andrej
A
Wahl
Sharon M
SM
D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005881:Gingiva / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D005883:Gingival Crevicular Fluid / Q000737:chemistry / Q000378:metabolism*; D005891:Gingivitis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D009569:Nitric Oxide / Q000032:analysis / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010510:Periodontal Diseases / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D018713:Prevotella intermedia / Q000302:isolation & purification
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase