High-density lipoproteins: an emerging target in the prevention of cardiovascular disease.
High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their beneficial influence on the arterial wall. A number of exciting therapeutic strategies have been developed that target HDL and its ability to protect against the development of atherosclerotic plaque. This paper will review how the promotion of the functional properties of HDL inhibits the formation of atherosclerotic plaque and stabilises lesions in patients with established disease.
Cutri
Belinda A
BA
The Heart Research Institute, Camperdown, Sydney, NSW 2050, Australia.
Hime
Neil J
NJ
Nicholls
Stephen J
SJ
D000818:Animals; D050197:Atherosclerosis / Q000517:prevention & control; D001693:Biological Transport, Active / Q000502:physiology; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control*; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000502:physiology; D008075:Lipoproteins, HDL / Q000502:physiology*; D008954:Models, Biological; D020011:Protective Agents / Q000627:therapeutic use
D008076:Cholesterol, HDL; D008055:Lipids; D008075:Lipoproteins, HDL; D020011:Protective Agents; D002784:Cholesterol