title: Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population.
abstract: BACKGROUND
  The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis. Polymorphisms in the promoter region of the FAS (-1377G>A and -670A>G) and FASL (-844C>T) have been shown to alter the transcriptional activities of these genes. In order to evaluate the contribution of these polymorphisms to the risk of lung cancer, we carried out a case-control study in a Korean population.
  
  
  METHODS
  The FAS and FASL genotypes were determined in 582 lung cancer patients and 582 healthy control subjects who were frequency-matched for age and gender.
  
  
  RESULTS
  The FAS and FASL genotypes and the FAS haplotypes exhibited no apparent relationship with the risk of lung cancer. In addition, there was no significant interaction between the FAS and FASL polymorphisms in the development of lung cancer.
  
  
  CONCLUSIONS
  These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.
authors.affiliation: Cancer Research Institute, School of Medicine, Kyungpook National University, Dong In 2Ga 101, Daegu 700-422, Republic of Korea.
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Park
authors.forename: Jin Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Kim
authors.forename: Jin Sung
authors.initials: JS
authors.lastname: Jang
authors.forename: Won Kee
authors.initials: WK
authors.lastname: Lee
authors.forename: Sung Ick
authors.initials: SI
authors.lastname: Cha
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Sin
authors.initials: S
authors.lastname: Kam
authors.forename: Dong Sun
authors.initials: DS
authors.lastname: Kim
authors.forename: Rang-Woon
authors.initials: RW
authors.lastname: Park
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Sung Beom
authors.initials: SB
authors.lastname: Han
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Jung
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D019014:fas Receptor / Q000235:genetics*
chemical_list: D053222:Fas Ligand Protein; D019014:fas Receptor