title: Relative moldiness index as predictor of childhood respiratory illness.
abstract: The results of a traditional visual mold inspection were compared to a mold evaluation based on the Relative Moldiness Index (RMI). The RMI is calculated from mold-specific quantitative PCR (MSQPCR) measurements of the concentration of 36 species of molds in floor dust samples. These two prospective mold evaluations were used to classify the mold condition in 271 homes of infants. Later, the development of respiratory illness was measured in the infants living in these homes and the predictive value of each classification system was evaluated. The binary classification of homes as either moldy or non-moldy by on-site visual home inspection was not predictive of the development of respiratory illness (wheeze and/or rhinitis) (P=0.27). Conversely, a method developed and validated in this paper, using the RMI index fit to a logistic function, can be used to predict the occurrence of illness in homes and allows stake-holders the choice among various levels of risk.
authors.affiliation: US Environmental Protection Agency, Cincinnati, OH, USA. vesper.stephen@epa.gov
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Vesper
authors.forename: Craig
authors.initials: C
authors.lastname: McKinstry
authors.forename: Richard A
authors.initials: RA
authors.lastname: Haugland
authors.forename: Yulia
authors.initials: Y
authors.lastname: Iossifova
authors.forename: Grace
authors.initials: G
authors.lastname: Lemasters
authors.forename: Linda
authors.initials: L
authors.lastname: Levin
authors.forename: Gurjit K
authors.initials: GK
authors.lastname: Khurana Hershey
authors.forename: Manuel
authors.initials: M
authors.lastname: Villareal
authors.forename: David I
authors.initials: DI
authors.lastname: Bernstein
authors.forename: James
authors.initials: J
authors.lastname: Lockey
authors.forename: Tiina
authors.initials: T
authors.lastname: Reponen
mesh_terms: D005658:Fungi / Q000145:classification / Q000472:pathogenicity; D006801:Humans; D007223:Infant; D016133:Polymerase Chain Reaction; D012140:Respiratory Tract Diseases / Q000382:microbiology*