Serum endostatin and vascular endothelial growth factor levels in patients with pre-eclampsia.
We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. We determined VEGF and endostatin levels in the sera of 20 healthy, non-pregnant women and 64 pregnant women: 20 healthy, 20 with mild pre-eclampsia and 24 with severe pre-eclampsia. Serum levels of these factors in non-pregnant women were similar to those in healthy pregnant women. However, serum levels were significantly higher with mild or severe pre-eclampsia compared with normal pregnancies and significantly higher with severe rather than with mild pre-eclampsia. Elevated levels significantly increased risk more than severity of pre-eclampsia. VEGF and endostatin could be used to differentiate between pre-eclamptic and normal pregnancies and to discriminate mild pre-eclampsia from severe pre-eclampsia.
Mahmound
R A K
RA
Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt. randa592003@yahoo.co.uk
Abdel-Raouf
M
M
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D003971:Diastole; D016002:Discriminant Analysis; D004534:Egypt; D043169:Endostatins / Q000097:blood* / Q000502:physiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013599:Systole; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000502:physiology
D015415:Biomarkers; D043169:Endostatins; D042461:Vascular Endothelial Growth Factor A