Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect.
We report a 69-year-old man with cytokine-resistant metastatic renal cell carcinoma treated with reduced-intensity unrelated cord blood transplantation. The patient achieved durable donor engraftment with minimal graft-versus-host disease. The patient showed regression of metastatic disease, providing the first evidence of a graft-versus-tumor effect on a solid tumor resulting from cord blood graft.
Takami
A
A
Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan. takami@med3.m.kanazawa-u.ac.jp
Takamatsu
H
H
Yamazaki
H
H
Ishiyama
K
K
Okumura
H
H
Ohata
K
K
Konaka
H
H
Asakura
H
H
Namiki
M
M
Nakao
S
S
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D036101:Cord Blood Stem Cell Transplantation; D006086:Graft vs Host Disease / Q000150:complications; D020350:Graft vs Tumor Effect; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D009362:Neoplasm Metastasis / Q000628:therapy; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome