title: [Prevention of osteoporosis by foods and dietary supplements. "Kinnotsubu honegenki": a fermented soybean (natto) with reinforced vitamin K2 (menaquinone-7)].
abstract: In recent years, it has been proven that vitamin K(2) has important roles not only in blood coagulation but also in bone metabolism. We developed a Bacillus subtilis (natto) strain with high productivity of vitamin K(2) (Menaquinone-7), and commercialized a natto with reinforced vitamin K(2) by use of the strain. The natto, named "Kinnotsubu honegenki", was granted a health claim based on our clinical studies which demonstrated that intake of the natto stimulated gamma-carboxylation of osteocalcin.
authors.affiliation: Mizkan Co. Ltd, Chilled Foods Company, Marketing Department, Technical Division.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takemura
mesh_terms: D000818:Animals; D001412:Bacillus subtilis / Q000378:metabolism; D005285:Fermentation; D058870:Food, Organic; D006801:Humans; D015675:Osteocalcin / Q000378:metabolism; D051381:Rats; D013025:Glycine max; D024482:Vitamin K 2 / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D015675:Osteocalcin; D024482:Vitamin K 2; C062629:menaquinone 7