title: Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis.
abstract: Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).
authors.affiliation: Department of Neurology and Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA. rinkerj@neuro.wustl.edu
authors.forename: John R
authors.initials: JR
authors.lastname: Rinker
authors.forename: Kathryn
authors.initials: K
authors.lastname: Trinkaus
authors.forename: Anne H
authors.initials: AH
authors.lastname: Cross
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000134:cerebrospinal fluid*; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D007145:Immunoglobulin kappa-Chains