Dynamic model of the process of protein synthesis in eukaryotic cells.
Protein synthesis is the final step of gene expression in all cells. In order to understand the regulation of this process, it is important to have an accurate model that incorporates the regulatory steps. The model presented in this paper is composed of set of differential equations which describe the dynamics of the initiation process and its control, as well as peptide elongation, starting with the amino acids available for peptide creation. A novel approach for modeling the elongation process permits useful prediction of protein production and consumption of energy and amino acids, as well as ribosome loading rate and ribosome spacing on the mRNA.
Skjøndal-Bar
Nadav
N
Department for Engineering Cybernetics, Norwegian University of Science and Technology, Trondheim, Norway. barc@itk.ntnu.no
Morris
David R
DR
D003198:Computer Simulation; D008954:Models, Biological; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*