[Modulating effect of antileukemia drugs on the cellular susceptibility in chronic myeloid leukemia to cytotoxic lymphocytes].
A 24-hour pre-treatment of leukemic K-562 cells with busulfan or N-hydroxycarbamide (rather than cytarabine) lowered their resistance to the toxic effect of peripheral blood mononuclear cells. Non-linear modulating influence was registered even at low dosage of cytostatics which actually could not affect leukemic cell viability.
Cherepovich
V S
VS
Shakhlevich
E V
EV
Antonenko
E V
EV
Lotkova
E S
ES
Grinëv
V V
VV
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002066:Busulfan / Q000494:pharmacology; D003561:Cytarabine / Q000494:pharmacology; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D020014:K562 Cells; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000628:therapy*; D007963:Leukocytes, Mononuclear
D003561:Cytarabine; D002066:Busulfan; D006918:Hydroxyurea