title: The sea urchin kinome: a first look.
abstract: This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is closer to the Drosophila kinome (239) than the human kinome (518) with respect to total kinase number. However, the diversity of sea urchin kinases is surprisingly similar to humans, since the urchin kinome is missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the sea urchin kinome combines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the sea urchin kinases are involved with signal transduction, and approximately 88% of the signaling kinases are expressed in the developing embryo. These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism.
authors.affiliation: DCMB Group, Duke University, Box 91000, Durham, NC 27708, USA. cabrad@duke.edu
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Bradham
authors.forename: Kathy R
authors.initials: KR
authors.lastname: Foltz
authors.forename: Wendy S
authors.initials: WS
authors.lastname: Beane
authors.forename: Maria I
authors.initials: MI
authors.lastname: Arnone
authors.forename: Francesca
authors.initials: F
authors.lastname: Rizzo
authors.forename: James A
authors.initials: JA
authors.lastname: Coffman
authors.forename: Arcady
authors.initials: A
authors.lastname: Mushegian
authors.forename: Manisha
authors.initials: M
authors.lastname: Goel
authors.forename: Julia
authors.initials: J
authors.lastname: Morales
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Geneviere
authors.forename: François
authors.initials: F
authors.lastname: Lapraz
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Robertson
authors.forename: Hemant
authors.initials: H
authors.lastname: Kelkar
authors.forename: Mariano
authors.initials: M
authors.lastname: Loza-Coll
authors.forename: Ian K
authors.initials: IK
authors.lastname: Townley
authors.forename: Michael
authors.initials: M
authors.lastname: Raisch
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Roux
authors.forename: Thierry
authors.initials: T
authors.lastname: Lepage
authors.forename: Christian
authors.initials: C
authors.lastname: Gache
authors.forename: David R
authors.initials: DR
authors.lastname: McClay
authors.forename: Gerard
authors.initials: G
authors.lastname: Manning
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D010766:Phosphorylation; D010802:Phylogeny; D011494:Protein Kinases / Q000145:classification / Q000235:genetics*; D012617:Sea Urchins / Q000145:classification / Q000196:embryology / Q000235:genetics* / Q000254:growth & development*; D015398:Signal Transduction
chemical_list: D011494:Protein Kinases