Critical ischemia time in a model of spinal cord section. A study performed on dogs.
Vascular changes after acute spinal cord trauma are important factors that predispose quadriplegia, in most cases irreversible. Repair of the spinal blood flow helps the spinal cord recovery. The average time to arrive and perform surgery is 3 h in most cases. It is important to determine the critical ischemia time in order to offer better functional prognosis. A spinal cord section and vascular clamping of the spinal anterior artery at C5-C6 model was used to determine critical ischemia time. The objective was to establish a critical ischemia time in a model of acute spinal cord section. Four groups of dogs were used, anterior approach and vascular clamp of spinal anterior artery with 1, 2, 3, and 4 h of ischemia and posterior hemisection of spinal cord at C5-C6 was performed. Clinical evaluation was made during 12 weeks and morphological evaluation at the end of this period. We obtained a maximal neurological coordination at 23 days average. Two cases showed sequels of right upper limb paresis at 1 and 3 ischemia hours. There was nerve conduction delay of 56% at 3 h of ischemia. Morphological examination showed 25% of damaged area. The VIII and IX Rexed's laminae were the most affected. The critical ischemia time was 3 h. Dogs with 4 h did not exhibit any recovery.
Bitar Alatorre
Wadih Emilio
WE
Instituto Mexicano del Seguro Social, Orthopaedics, Guadalajara, Jalisco, Mexico. dremiliobitar@prodigy.net.mx
Garcia Martinez
David
D
Rosales Corral
Sergio A
SA
Flores Soto
Mario E
ME
Velarde Silva
Gustavo
G
Portilla de Buen
Eliseo
E
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D009410:Nerve Degeneration / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D009431:Neural Conduction; D010291:Paresis / Q000473:pathology / Q000503:physiopathology*; D020127:Recovery of Function; D013116:Spinal Cord / Q000098:blood supply* / Q000473:pathology; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D013525:Surgical Instruments; D013997:Time Factors