title: Synthesis of the C1-C16 fragment of ionomycin using a neutral (eta3-allyl)iron complex.
abstract: Key steps in the synthesis of the C1-C16 polyketide fragment of ionomycin were the nucleophilic addition of an organocuprate to a neutral (eta3-allyl)iron complex and the construction of a beta-diketone moiety by the Rh-catalysed rearrangement of an alpha-diazo-beta-hydroxyketone.
authors.affiliation: School of Chemistry, Leeds University, Leeds, UKLS2 9JT.
authors.forename: John P
authors.initials: JP
authors.lastname: Cooksey
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Kocienski
authors.forename: Ying-fa
authors.initials: YF
authors.lastname: Li
authors.forename: Stefan
authors.initials: S
authors.lastname: Schunk
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Snaddon
mesh_terms: D000498:Allyl Compounds; D007202:Indicators and Reagents; D015759:Ionomycin / Q000138:chemical synthesis* / Q000737:chemistry*; D007501:Iron; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D007202:Indicators and Reagents; D015759:Ionomycin; D007501:Iron