title: Functional genomics and its implications for molecular medicine.
abstract: Technological development in genetics and genomics provides unprecedented possibilities to identify the underlying molecular basic of many common diseases. With the availability of the human genome sequence and growing information on the most frequent DNA variations combined with the molecular analysis on the RNA expression and protein level, diseases might be characterized in the future at the molecular level. Describing gene function anf the specific role of DNA, RNA, and proteins in the disease process provides novel diagnosis tools and treatment. Ultimately how the unique genetic signature of an individual influences the risk and prognosis of disease will be the basis for individualized medicine in the years to come.
authors.affiliation: Department of Medicine, Medical College of Wisconsin, and Department of Pediatrics, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, USA. broeckel@mcw.edu
authors.forename: Ulrich
authors.initials: U
authors.lastname: Broeckel
authors.forename: Karen
authors.initials: K
authors.lastname: Maresso
authors.forename: Subra
authors.initials: S
authors.lastname: Kugathasan
mesh_terms: D004252:DNA Mutational Analysis; D005819:Genetic Markers; D005821:Genetic Techniques; D005826:Genetics, Medical; D015894:Genome, Human; D023281:Genomics; D016045:Human Genome Project; D006801:Humans; D008967:Molecular Biology; D012313:RNA / Q000032:analysis
chemical_list: D005819:Genetic Markers; D012313:RNA