title: Protein heat capacity: inconsistencies in the current view of cold denaturation.
abstract: The present study shows on the basis of the thermodynamic stability criterion (partial differential S/partial differential T)p>0 that partitioning of the entropy of cold-unfolding of a protein into independent positive conformational and negative hydrational contributions is incorrect. Furthermore it provides a new microscopic interpretation of protein heat capacity that takes into account the significant fluctuations in energy and entropy which result from the small size of these macromolecules.
authors.affiliation: Institut für Physikalische Chemie, Westfälische Wilhelms-Universität, Münster, Schlossplatz 4/7, 48143 Münster, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Hallerbach
authors.forename: H J
authors.initials: HJ
authors.lastname: Hinz