title: Pulmonary regurgitation is a powerful factor influencing QRS duration in patients after surgical repair of tetralogy of Fallot. A magnetic resonance imaging (MRI) study.
abstract: OBJECTIVE
  QRS prolongation is a negative prognostic factor for the development of ventricular arrhythmia after repair of tetralogy of Fallot (TOF). In this MRI study, we performed a multivariate analysis to determine the influence of volumetric and functional parameters as well as time factors on QRS duration.
  
  
  RESULTS
  Sixty-seven patients after surgical repair of TOF were studied using a 1.5T MRI. Measurement of the ventricles was performed with a multislice-multiphase sequence. Left and right ventricular volumes, ejection fractions (EF) and myocardial masses were determined. Pulmonary regurgitant fraction (PRF) was quantified by velocity encoded flow measurement in the main pulmonary artery. Maximum QRS duration was taken from a 12-channel ECG. Mean maximum QRS duration was 132 ms (+/- 29 ms). Mean PRF was 29.2% (+/- 13.4%). QRS duration correlated significantly with PRF (r = 0.49; p < 0.01; n = 54) and with right ventricular enddiastolic volume index (RVEDVI) (r = 0.29; p < 0.05; n = 67). Multivariate analysis revealed that the combination of PRF, postoperative period, age at surgical repair, and left ventricular (LV) enddiastolic volume are correlated with QRS prolongation.
  
  
  CONCLUSIONS
  In patients after repair of TOF, pulmonary regurgitation is related to QRS prolongation. Furthermore, even LV size plays a role in the enlargement of the QRS complex.
authors.affiliation: Department of Radiology and Nuclear Medicine, Charité, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany. matthias.grothoff@charite.de
authors.forename: M
authors.initials: M
authors.lastname: Grothoff
authors.forename: B
authors.initials: B
authors.lastname: Spors
authors.forename: H
authors.initials: H
authors.lastname: Abdul-Khaliq
authors.forename: M
authors.initials: M
authors.lastname: Abd El Rahman
authors.forename: V
authors.initials: V
authors.lastname: Alexi-Meskishvili
authors.forename: P
authors.initials: P
authors.lastname: Lange
authors.forename: R
authors.initials: R
authors.lastname: Felix
authors.forename: M
authors.initials: M
authors.lastname: Gutberlet
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011665:Pulmonary Valve Insufficiency / Q000503:physiopathology*; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D013318:Stroke Volume; D013771:Tetralogy of Fallot / Q000503:physiopathology* / Q000601:surgery