title: CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.
abstract: Vgamma9Vdelta2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vgamma9Vdelta2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function.
authors.affiliation: Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Caccamo
authors.forename: Luca
authors.initials: L
authors.lastname: Battistini
authors.forename: Marc
authors.initials: M
authors.lastname: Bonneville
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Poccia
authors.forename: Jean Jacques
authors.initials: JJ
authors.lastname: Fournié
authors.forename: Serena
authors.initials: S
authors.lastname: Meraviglia
authors.forename: Giovanna
authors.initials: G
authors.lastname: Borsellino
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kroczek
authors.forename: Carmela
authors.initials: C
authors.lastname: La Mendola
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Scotet
authors.forename: Francesco
authors.initials: F
authors.lastname: Dieli
authors.forename: Alfredo
authors.initials: A
authors.lastname: Salerno
mesh_terms: D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte; D001402:B-Lymphocytes / Q000276:immunology*; D023201:CD40 Ligand; D002450:Cell Communication / Q000276:immunology; D005260:Female; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D060889:Inducible T-Cell Co-Stimulator Protein; D016753:Interleukin-10 / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine / Q000032:analysis*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; C095085:CXCR5 protein, human; C556692:ICOS protein, human; D060889:Inducible T-Cell Co-Stimulator Protein; D016692:Receptors, Antigen, T-Cell, gamma-delta; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D016753:Interleukin-10; D023201:CD40 Ligand; D015847:Interleukin-4