Spectral, electrical conductivity and biological activity properties of some new azopyrimidine derivatives and their complexes.
The electronic absorption spectra of 5-(o-substituted phenylazo)-6-amino-2-thiouracils and 6-(o-substituted phenylazo)-5-aminouracils containing different substituents are studied at different pH's. The dissociation constants are evaluated and discussed. Phenomenon of tautomerism is more supported by (1)H NMR and (13)C NMR spectra. The electrical conductivity of some ligands and their Co(II), Ni(II) and Cu(II) complexes in the temperature range 293-150K favoured their semiconducting properties where the metal ion forms a bridge to facilitate the flow of the current. The biological activity of some ligands and their complexes are tested against a number of Gram-positive and Gram-negative bacteria. The results showed that some of the compounds have a well considerable activity against some of the organisms.
Masoud
Mamdouh S
MS
Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt. drmsmasoud@yahoo.com
Khalil
Ekram A
EA
Ramadan
Ahmed M
AM
Gohar
Yousry M
YM
Sweyllam
Amr
A
D003035:Cobalt / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D019216:Metals, Heavy / Q000737:chemistry / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry / Q000378:metabolism; D011743:Pyrimidines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013053:Spectrophotometry / Q000379:methods*; D013696:Temperature
D008024:Ligands; D019216:Metals, Heavy; D011743:Pyrimidines; D003035:Cobalt; D003300:Copper; D009532:Nickel