title: Synthesis of polypyridine-graft-PEG copolymer for protein repellent and stable interface.
abstract: Polypyridine grafted with poly(ethylene glycol) (Py-g-PEG) have been synthesized. Radical copolymerization of methyl-terminated PEG macromonomer with 4-pyridylmethyl methacrylate homogeneously proceeded and the obtained copolymer spontaneously adsorbs from aqueous solution onto gold surfaces, where the pyridine parts act as the multipoint anchor to the surface and the PEG parts provide the strong steric repulsion between the chains. As a result, the highly protein repellent and stable surface was constructed through multipoint pyridine attachment as compared with singlepoint pyridine attachment. Py-g-PEGs thus synthesized are promising material to functionalize metal and semiconductor material and to self-assemble into micelle in biotechnological and biomedical field.
authors.affiliation: Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Satomi
authors.forename: Koji
authors.initials: K
authors.lastname: Ueno
authors.forename: Yohei
authors.initials: Y
authors.lastname: Fujita
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Junzo
authors.initials: J
authors.lastname: Tanaka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tateishi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Otsuka
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D036103:Nanotechnology / Q000379:methods*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013499:Surface Properties
chemical_list: D011108:Polymers; D011506:Proteins; D011725:Pyridines; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols