[Unsolved problems of human cell defence against radiation].
The complex of human cell defence systems against gamma-radiation was investigated: DNA repair, antiradical system, GST-family M1 and T1, radioadaptive response. Were compared in repair-deficient cells the action of natural (carlic extract) and synthetic (crown-compound) antimutagens. New approach related to the detection of the activity of different defence systems is developing. It helps to estimate the individual sensitivity to mutagens.
Zasukhina
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D000222:Adaptation, Physiological; D000975:Antioxidants / Q000378:metabolism; D002478:Cells, Cultured; D043844:Crown Ethers / Q000494:pharmacology; D004260:DNA Repair; D004535:Ehlers-Danlos Syndrome / Q000235:genetics / Q000378:metabolism; D005720:Gamma Rays; D005737:Garlic / Q000737:chemistry; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016296:Mutagenesis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D011110:Polymorphism, Genetic; D011836:Radiation Tolerance
D000975:Antioxidants; D043844:Crown Ethers; D005982:Glutathione Transferase; D010936:Plant Extracts; C413545:glutathione S-transferase T1