[Examination of an imaging method in early Alzheimer disease diagnosis support system (VSRAD)].
The use of voxel-based morphometry (VBM) has recently become a popular tool for the early diagnosis of Alzheimer disease. The Voxel-Based Specific Regional Analysis System for Alzheimer's Disease (VSRAD) is a clinically useful VBM that employs MRI. However, there has been insufficient information about the influence of the image pickup apparatus and imaging conditions in terms of the value calculated by the sensitivity correction. We therefore reviewed this problem in a volunteer who provided consent. We were able to confirm reproducibility under the same conditions. When changing the image pickup apparatus and conditions, the average Z-score of 0.18+/-0.21 became larger, and the change in Z-score increased when imaging was done in the axial plane. Further, the average Z-score of 0.06+/-0.21 for sensitivity correction use was high on average by 0.19+/-0.16 for phased-array uniformity enhancement (PURE) and low for surface coil intensity correction (SCIC).
Goto
Masami
M
Department of Radiological Technology, University of Tokyo Hospital.
Aoki
Shigeki
S
Abe
Osamu
O
Masumoto
Tomohiko
T
Watanabe
Yasushi
Y
Satake
Yoshiroh
Y
Nishida
Katsuji
K
Ino
Kenji
K
Yano
Keiichi
K
Iida
Kyohhito
K
Mima
Kazuo
K
Ohtomo
Kuni
K
D000328:Adult; D000544:Alzheimer Disease / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity