title: Urinary F2-isoprostane metabolite levels in children with sleep-disordered breathing.
abstract: Oxidant stress-related mechanisms have been proposed as a major contributor to the increased prevalence of cardiovascular morbidity in adult patients with sleep-disordered breathing. Isoprostanes provide a reliable biomarker of oxidant injury in vivo. The purpose of the present study was to examine the hypothesis that oxidant stress, as evidenced by increased levels of F2-isoprostane metabolites (IsoP-m) in urine, is present in children with a spectrum of sleep-disordered breathing. Assays were performed on urinary samples obtained from each of 47 pediatric patients immediately upon awakening after standard overnight polysomnography. Of the subjects, 15% had mild, 9% had moderate, and 6% had severe sleep-disordered breathing. After controlling for correlations between BMI and IsoP-m and SpO2 values, IsoP-m values were unrelated to any polysomnographic measures. The absence of increased levels of urinary F2-isoprostane metabolites in children with sleep-disordered breathing suggests that oxidative stress is not a significant feature of pediatric sleep-disordered breathing.
authors.affiliation: Department of Psychology, West Virginia University, Morgantown, WV 26506-6040, USA.
authors.forename: Hawley E
authors.initials: HE
authors.lastname: Montgomery-Downs
authors.forename: Jyoti
authors.initials: J
authors.lastname: Krishna
authors.forename: L Jackson
authors.initials: LJ
authors.lastname: Roberts
authors.forename: David
authors.initials: D
authors.lastname: Gozal
mesh_terms: D015992:Body Mass Index; D002648:Child; D028441:F2-Isoprostanes / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D012016:Reference Values; D012891:Sleep Apnea Syndromes / Q000652:urine*
chemical_list: D028441:F2-Isoprostanes; D010100:Oxygen