Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: a new approach toward prodrug-procontrast complexes.
We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.
Frullano
Luca
L
Department of Chemistry, Biochemistry and Molecular and Cell Biology, Neurobiology and Physiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
Tejerina
Baudilio
B
Meade
Thomas J
TJ
D003287:Contrast Media / Q000138:chemical synthesis*; D004317:Doxorubicin / Q000737:chemistry*; D005682:Gadolinium; D019786:Gadolinium DTPA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D008968:Molecular Conformation; D008970:Molecular Weight; D011355:Prodrugs
D003287:Contrast Media; D011355:Prodrugs; D004317:Doxorubicin; D005682:Gadolinium; D019786:Gadolinium DTPA