title: Novel alternative for the N-S bond formation and its application to the synthesis of benzisothiazol-3-ones.
abstract: [reaction: see text] The synthesis of a series of benzisothiazolone derivatives starting from the readily available methyl thiosalicylate is presented. The key cyclization step features the formation of a N-acylnitrenium ion, generated by the hypervalent iodine reagent PIFA, and its succeeding intramolecular trapping by the thiole moiety leading to the construction of the title compounds by formation of a new N-S bond.
authors.affiliation: Departamento de Química Organica II, Facultad de Ciencia y Tecnología, Euskal Herriko Unibertsitatea, P.O. Box 644, 48080 Bilbao, Spain.
authors.forename: Arkaitz
authors.initials: A
authors.lastname: Correa
authors.forename: Imanol
authors.initials: I
authors.lastname: Tellitu
authors.forename: Esther
authors.initials: E
authors.lastname: Domínguez
authors.forename: Raul
authors.initials: R
authors.lastname: SanMartin