Defining the role of vascular smooth muscle cell apoptosis in atherosclerosis.
Vascular smooth muscle cell (VSMC) apoptosis occurs in many arterial diseases, including aneurysm formation, angioplasty restenosis and atherosclerosis. Although VSMC apoptosis promotes vessel remodelling, coagulation and inflammation, its precise contribution to these diseases is unknown, given that apoptosis frequently accompanies vessel injury or alterations to flow. Using transgenic mice with selective induction of VSMC apoptosis, a recent study has precisely determined the direct consequences of VSMC apoptosis in both normal vessels and atherosclerotic plaques. Surprisingly, normal arteries can withstand huge cell losses with little change in active or passive properties. Normal vessels demonstrate highly efficient clearance of apoptotic bodies, even in the absence of professional phagocytes. In contrast, VSMC apoptosis alone is sufficient to induce multiple features of vulnerability to rupture in plaques, identifying VSMC apoptosis as a critical process determining plaque stability.
Clarke
Murray
M
Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, UK.
Bennett
Martin
M
D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology*; D001808:Blood Vessels / Q000166:cytology; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D012422:Rupture, Spontaneous / Q000209:etiology