[Effect of the ethyl acetate extract of zhi ju zi on serum makers and the expression of TGF-beta1 in rats with hepatic fibrosis].
OBJECTIVE
To study the effect of the Ethyl Acetate Extract of Zhi Ju Zi on hepatic fibrosis.


METHODS
Model of liver fibrosis in rats was induced by CCl4. The level of hyaluronic acid (HA) and laminin (LN) was detected by RIN. The expression of TGF-beta1 of the rat liver was detected by RT-PCR.


RESULTS
After treatment, the level of HA was apparently decreased (P < 0.05); the level of LN wsn't apparently different with the Colchicin group (P > 0.05); The expression of TGF-beta1, was apparently decreased (P < 0.05) CONCLUSION: The Ethyl Acetate Extract of Zhi Ju Zi can effectviely decrease the level of serum markers of hepatic fibrosis and the expression of TGF-beta1.
Wang
Fei
F
Renmin Hospital, Wuhan University, Wuhan 430060, China.
Zhang
Hong
H
Liu
Xiu-ling
XL
D000085:Acetates; D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D006820:Hyaluronic Acid / Q000097:blood*; D007797:Laminin / Q000097:blood*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000097:blood* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D027823:Rhamnaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D016212:Transforming Growth Factor beta / Q000378:metabolism
D000085:Acetates; D007797:Laminin; D010936:Plant Extracts; D016212:Transforming Growth Factor beta; C007650:ethyl acetate; D006820:Hyaluronic Acid; D003078:Colchicine