Chemopreventive property of dietary ginger in rat urinary bladder chemical carcinogenesis.
The modifying potential of ginger on the development of preneoplasia and tumors in the male Wistar rat urinary bladder was investigated in a 36-week-long initiation-promotion assay for chemical carcinogenesis. Groups G1 to G3 were given 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in drinking water for 5 weeks and a 3% uracil meal for the subsequent 3 weeks. Groups G4 and G5 were treated with 3% uracil only for the same period. After these steps, groups G2, and G3 and G4 were fed for 26 weeks a ginger extract mixed at 0.5 and 1.0% in a basal diet, respectively. Thirty six weeks after the beginning of the experiment all rats were killed. The multiplicity of urothelial lesions (hyperplasia and neoplasia) was significantly lower (P = 0.013) in group G3 than in groups G1 and G2. The results suggest that 1.0% ginger meal exerts a protective effect on the post-initiation stage of rat chemically-induced urothelial carcinogenesis.
Ihlaseh
Shadia Muhammad
SM
Department of Morphology, Institute of Biosciences, UNESP São Paulo State University, Botucatu, 18618-000 SP, Brazil.
de Oliveira
Maria Luiza Cotrim
ML
Teràn
Elizabeth
E
de Camargo
João Lauro Viana
JL
Barbisan
Luís Fernando
LF
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002085:Butylhydroxybutylnitrosamine; D049109:Cell Proliferation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D018890:Chemoprevention / Q000379:methods*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D020939:Zingiber officinale; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014498:Uracil; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D010936:Plant Extracts; D002085:Butylhydroxybutylnitrosamine; D014498:Uracil