title: [Clinical features and treatment of 49 patients with anal canal adenocarcinoma].
abstract: OBJECTIVE
  To investigate the clinical features and treatment of anal canal adenocarcinoma.
  
  
  METHODS
  Clinical data of 49 patients with anal canal adenocarcinoma treated in our hospital from January 1965 to March 2002 were analyzed retrospectively.
  
  
  RESULTS
  The ratio of male to female was 1.3. The median age was 56 years old. Anal bleeding, tapering stool and anal lump were the most common symptoms. Chronic perianal diseases were complicated in 36.7% of the cases. The median follow-up was 66 months. Local recurrence and inguinal lymph node metastasis were found in 7 cases respectively, lung metastasis in 2, supraclavicular and mediastinal metastasis in 1 respectively. The 3-year survival rates in the patients with resection alone, radiochemotherapy alone, resection combined with radiochemotherapy, and without any treatment were 41.3%, 20.0%, 56.3% and 15.0%, respectively, and the 5-year survival rates were 34.4%, 0, 37.5%, 0, respectively.
  
  
  CONCLUSIONS
  Anal canal adenocarcinoma is a rare and fatal malignancy. Abdomino-perineal resection combined with postoperative radiochemotherapy is the principal treatment.
authors.affiliation: Department of Abdominal Surgery, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Sonthern China, Guangzhou 510060, China. liliren@medmail.com.cn
authors.forename: Li-ren
authors.initials: LR
authors.lastname: Li
authors.forename: De-sen
authors.initials: DS
authors.lastname: Wan
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Pan
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Zhou
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Wu
authors.forename: Zhen-hai
authors.initials: ZH
authors.lastname: Lu
authors.forename: Pei-rong
authors.initials: PR
authors.lastname: Ding
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000473:pathology; D001005:Anus Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult