title: BCG vaccine effectiveness against Buruli ulcer: a case-control study in Benin.
abstract: BCG remains the only possible prophylactic intervention against Buruli ulcer (BU). Estimating its public health impact on BU control is an important issue. We conducted a case-control study to investigate the vaccine effectiveness of routine BCG vaccine against BU in southern Benin. From August 2002 to August 2003, BCG vaccination status was obtained for 279 clinically diagnosed BU cases and 988 age- and sex-matched neighborhood controls. BCG coverage, which was estimated by the presence of a scar or a vaccination record, was 64.5% in cases and 67.2% in controls. There was no evidence of a protective effect of routine BCG vaccination against BU in southern Benin (vaccine effectiveness adjusted for socioeconomic status = 12%, 95% confidence interval = -24% to 37%).
authors.affiliation: Unité d'Epidemiologie, Ecole de Santé Publique, Université Catholique de Louvain, Brussels, Belgium. Fabienne.Nackers@epid.ucl.ac.be
authors.forename: Fabienne
authors.initials: F
authors.lastname: Nackers
authors.forename: Michèle
authors.initials: M
authors.lastname: Dramaix
authors.forename: Roch Christian
authors.initials: RC
authors.lastname: Johnson
authors.forename: Claude
authors.initials: C
authors.lastname: Zinsou
authors.forename: Annie
authors.initials: A
authors.lastname: Robert
authors.forename: Elisa
authors.initials: E
authors.lastname: DE Biurrun Bakedano
authors.forename: Judith R
authors.initials: JR
authors.lastname: Glynn
authors.forename: Françoise
authors.initials: F
authors.lastname: Portaels
authors.forename: René
authors.initials: R
authors.lastname: Tonglet
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001500:BCG Vaccine / Q000592:standards; D001541:Benin; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000517:prevention & control*; D019911:Mycobacterium ulcerans / Q000276:immunology; D012737:Sex Factors; D017192:Skin Diseases, Bacterial / Q000382:microbiology / Q000517:prevention & control*; D012883:Skin Ulcer / Q000382:microbiology / Q000517:prevention & control*; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D001500:BCG Vaccine