title: Novel, efficient total synthesis of natural 20(S)-camptothecin.
abstract: Enantiopure 20(S)-camptothecin has been prepared from a known hydroxypyridone through a novel approach that involves a Claisen rearrangement, an asymmetric nucleophilic ethylation, a Heck coupling and a Friedländer condensation as the key transformations.
authors.affiliation: Chimie Recherche (LEDSS), Université Joseph Fourier, 38041 Grenoble, France.
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Tang
authors.forename: Matej
authors.initials: M
authors.lastname: Babjak
authors.forename: Regan J
authors.initials: RJ
authors.lastname: Anderson
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Greene
authors.forename: Alice
authors.initials: A
authors.lastname: Kanazawa
mesh_terms: D002166:Camptothecin / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002166:Camptothecin