Presence of hydrosalpinx correlated to endometrial inflammatory response in vivo.
OBJECTIVE
To evaluate and compare the inflammatory response and mediators in the endometrium of patients with hydrosalpinges compared with normal controls.


METHODS
Retrospective case-control study.


METHODS
Urban medical center.


METHODS
Hysterectomy samples were identified as being affected by hydrosalpinx or salpingitis (n = 30) and were age-matched with control samples (n = 30).


METHODS
Fallopian tube and endometrial slides were analyzed for leukocytes and immunohistochemical techniques performed for cytokines (interleukin-2 [IL-2]).


METHODS
Evaluate and compare the endometrial inflammatory response (leukocytes and cytokines) from samples affected and non-affected by hydrosalpinx and salpingitis.


RESULTS
Examination of tubal and endometrial slides with hydrosalpinx demonstrated a statistically significant increase in the number of overall inflammatory cells. High-intensity immunohistochemical staining for IL-2 was demonstrated in 7.4% of controls versus 65% of cases.


CONCLUSIONS
A defined, identifiable, local response to hydrosalpingeal fluid has been demonstrated in the endometrium. This response consists of statistically significant elevations of leukocytes and IL-2. An inflammatory endometrial response may be an independent contributor to the decreased reproductive outcome observed in patients with hydrosalpinges.
Copperman
Alan B
AB
Mount Sinai School of Medicine, Department of Obstetrics and Gynecology, New York, New York, USA. acopperman@rmany.com
Wells
Valerie
V
Luna
Martha
M
Kalir
Tamara
T
Sandler
Benjamin
B
Mukherjee
Tanmoy
T
D016022:Case-Control Studies; D016207:Cytokines / Q000276:immunology*; D004716:Endometritis / Q000276:immunology* / Q000473:pathology*; D004717:Endometrium / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D012189:Retrospective Studies; D012488:Salpingitis / Q000276:immunology*; D013223:Statistics as Topic
D016207:Cytokines