Diagnostic performance of tests based on Trypanosoma cruzi excreted-secreted antigens in an endemic area for Chagas' disease in Bolivia.
The diagnostic performance of Trypanosoma cruzi excreted-secreted antigen (TESA)-based and conventional tests for Chagas' disease was evaluated in a field study with 742 sera from a population in an endemic area in the Department of Chuquisaca, Bolivia. Of the 742 samples, 329 (44.34 %) were positive in the TESA blot assay, which diagnosed 9 Trypanosoma cruzi-infected individuals missed by conventional serologic tests.
Zarate-Blades
Carlos Rodrigo
CR
Centro de Investigacion y Diagnóstico de la Enfermedad de Chagas, CIDECH, Universidad Mayor de San Francisco Xavier, Calle Dalence 243, Sucre, 617 Bolivia.
Bladés
Nelly
N
Nascimento
Marilda Savoia
MS
da Silveira
José Franco
JF
Umezawa
Eufrosina Setsu
ES
D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000953:Antigens, Protozoan / Q000276:immunology*; D015153:Blotting, Western; D001838:Bolivia / Q000453:epidemiology; D014355:Chagas Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000469:parasitology; D002648:Child; D002675:Child, Preschool; D019353:Endemic Diseases; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D011933:Reagent Kits, Diagnostic; D012698:Serologic Tests; D014349:Trypanosoma cruzi / Q000276:immunology*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D011933:Reagent Kits, Diagnostic