Total synthesis of topopyrones B and D.
[reaction: see text] We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work.
Tan
Jason Samuel
JS
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Ciufolini
Marco A
MA
D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
D000880:Anthraquinones; D011753:Pyrones; D059004:Topoisomerase I Inhibitors; C417105:topopyrone B; C417103:topopyrone D