title: Serum and urine concentrations of trypsinogen-activation peptide as markers for acute pancreatitis in cats.
abstract: The purpose of this study was to compare the clinical utility of the serum concentration of feline trypsin-like immunoreactivity (fTLI), the plasma and urine concentrations of trypsinogen-activation peptide (TAP), and the ratio of the urine TAP and creatinine concentrations (TAP:Cr) in the diagnosis of feline acute pancreatitis. We used 13 healthy cats and 10 cats with a diagnosis of acute pancreatitis. The mean serum fTLI and plasma TAP concentrations were significantly higher in the cats with acute pancreatitis than in the healthy cats (P < 0.05); the mean urine TAP concentrations and the median urine TAP:Cr ratios were not significantly different. Among the cats examined in this study, there was no benefit of plasma TAP over serum fTLI in the evaluation of suspected acute pancreatitis.
authors.affiliation: The Bobst Hospital, Animal Medical Center, New York, New York 10021, USA. RUN.DVM@Verizon.net
authors.forename: Heidi S
authors.initials: HS
authors.lastname: Allen
authors.forename: Jörg
authors.initials: J
authors.lastname: Steiner
authors.forename: John
authors.initials: J
authors.lastname: Broussard
authors.forename: Caroline
authors.initials: C
authors.lastname: Mansfield
authors.forename: David A
authors.initials: DA
authors.lastname: Williams
authors.forename: Boyd
authors.initials: B
authors.lastname: Jones
mesh_terms: D000208:Acute Disease; D000818:Animals; D015415:Biomarkers; D016022:Case-Control Studies; D002371:Cat Diseases / Q000097:blood* / Q000175:diagnosis / Q000652:urine*; D002415:Cats; D003404:Creatinine / Q000652:urine; D005260:Female; D008297:Male; D009842:Oligopeptides / Q000097:blood / Q000652:urine; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis / Q000652:urine / Q000662:veterinary*
chemical_list: D015415:Biomarkers; D009842:Oligopeptides; C080396:trypsinogen activation peptide; D003404:Creatinine