title: Highly enantioselective alpha-aminoxylation of aldehydes and ketones in ionic liquids.
abstract: As the first example for the synthesis of optically active alpha-hydroxyaldehydes and alpha-hydroxyketones in ionic liquids, we applied RTILs into L-proline catalyzed direct enantioselective alpha-aminoxylation of both aldehydes and ketones successfully. This protocol features a number of advantages, such as recycling of green solvents and chiral organocatalyst, high yields, excellent enantioselectivities, short reaction times, and broad substrate scope.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.forename: Zhi-Zhen
authors.initials: ZZ
authors.lastname: Huang
authors.forename: Xin-Liang
authors.initials: XL
authors.lastname: Li