title: Partial replacement of waxy cornstarch by recrystallized amylose retards the development of insulin resistance in rats.
abstract: We examined in rats whether or not the prolonged ingestion of recrystallized amylose (RCA) would prevent the development of insulin resistance. Rats were fed on a diet containing waxy cornstarch (WCS) as carbohydrate or a diet containing 30% RCA in place of WCS for 18 wk. Glucose tolerance test (GTT) was conducted at every four weeks. On wk 16, the plasma insulin response as assessed by the area under the curve was lower in the RCA diet group than in the WCS diet group. The fasting plasma insulin level tended to increase over time in both groups, but was lower in the RCA diet group on wk 16. An autopsy revealed that the adipose tissue mass and serum free fatty acid concentrations were significantly higher in the WCS diet group. The results suggest that prolonged ingestion of RCA had the effect of slowing the development of insulin resistance through a lower concentration of serum free fatty acids, presumably due to the prevention of adipocyte hypertrophy.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yuto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Motoi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yagishita
authors.forename: Koji
authors.initials: K
authors.lastname: Takeya
authors.forename: Kimio
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Shuhachi
authors.initials: S
authors.lastname: Kiriyama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Morita
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000688:Amylose / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D019540:Area Under Curve; D003460:Crystallization; D004032:Diet; D005227:Fatty Acids / Q000032:analysis; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007700:Kinetics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013213:Starch / Q000494:pharmacology*
chemical_list: D005227:Fatty Acids; D007328:Insulin; D013213:Starch; D000688:Amylose