title: [Effect of a novel soy fermented product enriched with isoflavones and calcium on bone tissue of rats].
abstract: The objective was to evaluate the effect of soy fermented product intake on the corporal weight and bone tissue of ovariectomized mature rats. This product was fermented with Enterococcus faecium and Lactobacillus jugurti and enriched with isoflavones and calcium. The animals were divided in 5 groups: sham-ovariectomized; ovariectomized; ovariectomized treated with soy fermented product enriched with isoflavones and calcium; ovariectomized treated with soy fermented product enriched with calcium and ovariectomized treated with non-fermented product enriched only with calcium. In order to evaluate the effect of the tested product on bone tissue (femur and tibia), the following parameters were analyzed: length; mechanical assay of three points; density (Archimedes principle); mineral content; calcium content; measure of the trabecular widths. The corporal weight of group treated with soy fermented product containing isoflavones and calcium showed no statistical difference from sham-ovariectomized group and trabecular widths tended to have larger than ovariectomized group. However, there was no significant difference to the other evaluated parameters in result of the diverse treatments. Thus, soy fermented product enriched with isoflavones and calcium inhibited the increasing of corporal weight caused by ovariectomy and revealed a tendency to trabecular protection after castration.
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, SP, Brasil.
authors.forename: Raquel
authors.initials: R
authors.lastname: Bedani
authors.forename: Elizeu Antonio
authors.initials: EA
authors.lastname: Rossi
authors.forename: José Salvador
authors.initials: JS
authors.lastname: Lepera
authors.forename: Charles Chenwei
authors.initials: CC
authors.lastname: Wang
authors.forename: Graciela Font
authors.initials: GF
authors.lastname: de Valdez
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002118:Calcium / Q000008:administration & dosage*; D004195:Disease Models, Animal; D016984:Enterococcus faecium / Q000737:chemistry; D005260:Female; D005269:Femur / Q000187:drug effects / Q000648:ultrastructure; D005285:Fermentation; D005527:Food, Fortified; D007529:Isoflavones / Q000008:administration & dosage*; D007778:Lactobacillus / Q000737:chemistry; D010024:Osteoporosis / Q000188:drug therapy*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000008:administration & dosage*; D013977:Tibia / Q000187:drug effects / Q000648:ultrastructure; D015014:Yogurt
chemical_list: D007529:Isoflavones; D030262:Soybean Proteins; D002118:Calcium