title: Pteratides I-IV, new cytotoxic cyclodepsipeptides from the Malaysian basidiomycete Pterula sp.
abstract: Four new cyclodepsipeptides, pteratides I-IV (1-4), have been isolated from the extract of a Pterula species collected from a Malaysian tropical forest. Homonuclear and heteronuclear 2D NMR techniques as well as MS fragmentation experiments, in combination with methanolysis, determined the gross structures of the peptides and showed that pteratides I and II each contained the nonproteinogenic amino acid 4-methylproline. The absolute configurations of the amino acids in pteratides I-IV were established using Marfey's method. Pteratides I and II are each potently cytotoxic against the P388 murine leukemia cell line (IC50 values of 41 and 40 nM, respectively). Pteratides III and IV show weaker, but still notable, activity with IC50 values of 7.4 and 2.9 microM, respectively.
authors.affiliation: Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
authors.forename: Chien-Hui
authors.initials: CH
authors.lastname: Chen
authors.forename: Gerhard
authors.initials: G
authors.lastname: Lang
authors.forename: Maya I
authors.initials: MI
authors.lastname: Mitova
authors.forename: Annabel C
authors.initials: AC
authors.lastname: Murphy
authors.forename: Anthony L J
authors.initials: AL
authors.lastname: Cole
authors.forename: Laily B
authors.initials: LB
authors.lastname: Din
authors.forename: John W
authors.initials: JW
authors.lastname: Blunt
authors.forename: Murray H G
authors.initials: MH
authors.lastname: Munro
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D047630:Depsipeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides