title: Teratoma in an adolescent with malignant transformation into embryonal rhabdomyosarcoma: case report.
abstract: BACKGROUND
  The somatic type tumors are occasionally found in nonseminomatous germ cell tumors in men. These malignancies are presumed to arise from malignant transformation (MT) of teratoma or by differentiation of totipotential germ cell.
  
  
  METHODS
  A case of MT of germ cell tumor in 17-year-old male into embryonal rhabdomyosarcoma is described. The histopathologic diagnosis was that of embryonal rhabdomyosarcoma in which no germ cell elements were found. The germ cell origin of transformed histology is supported by cytogenetic analysis (isochromosome 12p), and elevated alpha(1)-fetoprotein. Despite intensive therapy the patient died.
  
  
  CONCLUSIONS
  MT of teratoma is rare entity with poor prognosis.
authors.affiliation: Department of Pediatric Hematology and Oncology, Charles University, Second Medical School, University Hospital Motol, Prague, Czech Republic. david.sumerauer@lfmotol.cuni.cz
authors.forename: David
authors.initials: D
authors.lastname: Sumerauer
authors.forename: Ales
authors.initials: A
authors.lastname: Vicha
authors.forename: Anna
authors.initials: A
authors.lastname: Zuntova
authors.forename: Eva
authors.initials: E
authors.lastname: Stejskalova
authors.forename: Lenka
authors.initials: L
authors.lastname: Krskova
authors.forename: Edita
authors.initials: E
authors.lastname: Kabickova
authors.forename: Roman
authors.initials: R
authors.lastname: Kodet
authors.forename: Tomas
authors.initials: T
authors.lastname: Eckschlager
mesh_terms: D000293:Adolescent; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D018365:Neoplasm, Residual; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D018233:Rhabdomyosarcoma, Embryonal / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D013724:Teratoma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy