Chemopreventive actions of polyphenolic compounds in cancer.
Oxidative stress and associated mechanisms involving inflammation, aberrant signaling pathways and gap junction intercellular communication is increasingly associated with the pathogenesis of various chronic degenerative disorders such as atherosclerosis, neurodegeneration and cancer. Consumption of fruits, vegetables and beverages like teas continues to be suggested to have the capacity to reduce the incidence of cancer. The bioactive compounds including phenolics may be responsible for the chemopreventive effects. While the free radical scavenging and antioxidant properties of phenolics are well established, emerging literature reports suggest that their chemopreventive effects may also be ascribed to their ability to modulate components of cell signaling pathways. This paper reviews the potential chemoprevention role of phenolics with a focus on cellular signal transduction mechanisms and prevention of gap junction intercellular communication relevant to cancer.
Soobrattee
Muhammad A
MA
Department of Biosciences, Faculty of Science, University of Mauritius, Réduit, Republic of Mauritius.
Bahorun
Theeshan
T
Aruoma
Okezie I
OI
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D010636:Phenols / Q000737:chemistry / Q000627:therapeutic use*; D059808:Polyphenols; D015398:Signal Transduction / Q000187:drug effects
D000970:Antineoplastic Agents; D005419:Flavonoids; D016328:NF-kappa B; D010636:Phenols; D059808:Polyphenols; D002392:Catechin; C045651:epigallocatechin gallate