title: [Genetic polymorphism of glutathione-S-transferases and inhibition of DNA repair].
abstract: A complex investigation of different cell defence systems, such as: DNA repair, antioxidant system (SOD), xenobiotic detoxification system (glutathione-S-transferases M1 and T1), radioadaptive response (RAR) in lymphocytes of patients with hereditary disease of connective tissue (Elers-Danlose syndrome) was carried out. The frequency of genotype GSTM1 (0/0) in children with Elers-Danlose syndrome (23%) is lower as compared to the control group (44%). The lymphocytes of children with Elers-Danlose syndrome were characterized by reduced ability to repair gamma-induced damage of DNA. At given size of the samples of examined children no correlative relationships between GST-status of organism and the condition of other cell defence systems were revealed. The data obtained demonstrate the individual peculiarities of the defence systems in repair-deficient cells of the examined children.
authors.forename: N S
authors.initials: NS
authors.lastname: Kuz'mina
authors.forename: I M
authors.initials: IM
authors.lastname: Vasil'eva
authors.forename: T A
authors.initials: TA
authors.lastname: Sinelshchikova
authors.forename: A N
authors.initials: AN
authors.lastname: Semiachkina
authors.forename: G I
authors.initials: GI
authors.lastname: Kuznetsova
authors.forename: V A
authors.initials: VA
authors.lastname: Shevchenko
authors.forename: G D
authors.initials: GD
authors.lastname: Zasukhina
mesh_terms: D002648:Child; D004247:DNA / Q000032:analysis; D004260:DNA Repair / Q000235:genetics*; D004535:Ehlers-Danlos Syndrome / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D004247:DNA; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1