title: [Air pollution and cardiovascular and cerebrovascular disease: Epidemiologic data].
abstract: Recent convergent data suggest that air pollution affects the risk of acute atherothrombotic events including both myocardial infarction and ischemic stroke. The principal epidemiologic studies begun in the 1990s first examined the respiratory effects of atmospheric pollution and then focused on how pollution peaks affected cardiovascular risk. These studies used data from large metropolitan areas in North America and Asia as well as several large European cities to demonstrate the clear existence of a relation between air pollution and cardio- and cerebrovascular mortality. They also observed an increase in hospital admissions for myocardial infarctions and cerebrovascular accidents on days with high air pollution levels. The pollutants involved have not yet been clearly designated, but it appears that fine suspended particulate matter (PM2.5) and gaseous pollutants such as ozone appear to contribute strongly to these harmful effects. A complete analysis of these data shows the need for a thorough evaluation of the cardio- and cerebrovascular risks associated with air pollution, especially in French metropolitan areas. Precise identification of those at high risk from specific pollutants is essential to improve targeting of prevention strategies.
authors.affiliation: Observatoire des infarctus du myocarde de Côte-d'Or (Rico), Laboratoire de physiopathologie et pharmacologie, cardiovasculaires expérimentales, Faculté de médecine, Dijon. marianne.zeller@u-bourgogne.fr
authors.forename: Marianne
authors.initials: M
authors.lastname: Zeller
authors.forename: Maurice
authors.initials: M
authors.lastname: Giroud
authors.forename: Clotilde
authors.initials: C
authors.lastname: Royer
authors.forename: Isabelle
authors.initials: I
authors.lastname: Benatru
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Besancenot
authors.forename: Luc
authors.initials: L
authors.lastname: Rochette
authors.forename: Yves
authors.initials: Y
authors.lastname: Cottin
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000397:Air Pollution / Q000009:adverse effects* / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D005602:France / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D009203:Myocardial Infarction / Q000453:epidemiology / Q000401:mortality; D009569:Nitric Oxide / Q000009:adverse effects; D010126:Ozone / Q000009:adverse effects; D010316:Particle Size; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000401:mortality; D013458:Sulfur Dioxide / Q000009:adverse effects; D001335:Vehicle Emissions / Q000009:adverse effects
chemical_list: D000393:Air Pollutants; D001335:Vehicle Emissions; D013458:Sulfur Dioxide; D009569:Nitric Oxide; D010126:Ozone