The use of rocuronium and sevoflurane in acute intermittent porphyria--a case report.
Acute intermittent porphyria (AIP) is an inherited metabolic disorder caused by deficiency of porphobilinogen deaminase, an enzyme found in the synthetic pathway of heme. Acute attack of AIP may be precipitated by many factors during operation and anesthesia, including fasting, dehydration, stress, infection, and drugs. Acute attack of AIP is likely fatal. Therefore, the drugs recommended as being safe in anesthesia for porphyria patients are up-to-dately refreshed and renovated and the identification of whether a drug is safe or not is based on cumulative anecdotal experiences. Here, we report the safe use of rocuronium and sevoflurane for long exposure in a patient affected with acute intermittent porphyria.
Hsieh
Cheng-Hung
CH
Department of Anesthesiology, Taichung Veterans General Hospital, Taiwan, ROC.
Hung
Pei-Ching
PC
Chien
Chi-Tsung
CT
Shih
Yi-Ru
YR
Peng
Shih-Kuei
SK
Luk
Hsiang-Ning
HN
Tsai
Tzung-Chieh
TC
D000732:Androstanols / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D017118:Porphyria, Acute Intermittent / Q000150:complications*; D000077123:Rocuronium; D000077149:Sevoflurane
D000732:Androstanols; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D003473:Neuromuscular Nondepolarizing Agents; D000077149:Sevoflurane; D000077123:Rocuronium