Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex.
The availability of methods for quantifying tissue concentrations of messenger RNAs in the postmortem of the human brain has provided a number of new findings in schizophrenia. However, understanding how these findings actually relate to the disease process of schizophrenia requires knowledge both of the factors that might give rise to such changes in gene expression and of the impact of these changes on the function of the affected neural circuits. Consequently, this chapter provides a review of the potential causes and consequences of some of the schizophrenia-related transcriptome changes in the dorsolateral prefrontal cortex, a brain region implicated in the pathophysiology of certain core cognitive deficits in this illness.
Lewis
David A
DA
Department of Psychiatry, and Department of Neuroscience, University of Pittsburgh, 3811 O'Hara Street, W1652 BST, Pittsburgh, PA 15213-2593, USA. lewisda@upmc.edu <lewisda@upmc.edu>
Mirnics
Karoly
K
D000818:Animals; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D017397:Prefrontal Cortex / Q000473:pathology*; D012333:RNA, Messenger / Q000032:analysis; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*
D012333:RNA, Messenger