Molecular orchestration of the hepatic circadian symphony.
The circadian clock determines the rhythmic expression of many different genes throughout a 24-hour period. A recent study investigating the circadian regulation of liver proteins reveals multiple levels of regulation, including transcriptional, post-transcriptional and post-translational mechanisms.
Albrecht
Urs
U
Department of Medicine, Division of Biochemistry, University of Fribourg, Rue du Muséee, 1700 Fribourg, Switzerland. urs.albrecht@unifr.ch
D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008099:Liver / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic