title: Elevated circulating oxidized LDL levels in Japanese subjects with the metabolic syndrome.
abstract: In the present study, we examined the relationship between circulating oxidized low-density lipoprotein (LDL) and the metabolic syndrome in Japanese patients. Subjects who had no histories of coronary or peripheral artery disease and were taking no medications (n=119; age 57+/-10 years; male/female, 90:29) underwent a complete history and physical examination, determination of blood chemistries and oxidized LDL levels. In stepwise regression analysis, triglycerides (p=0.0001) and HDL-cholesterol (p=0.0493, inversely) were independently correlated to oxidized LDL levels. Furthermore, a significant association (p<0.0001) was found between circulating oxidized LDL levels and the accumulation of the number of the components of the metabolic syndrome. Oxidized LDL levels were one of the independent determinants of intima-media thickness of the common carotid artery, a surrogate marker of atherosclerosis. The present study reveals that circulating oxidized LDL levels are strongly associated with the metabolic syndrome. Our results suggest that elevation of oxidized LDL may be a possible molecular link between accelerated atherosclerosis and the metabolic syndrome in Japanese subjects.
authors.forename: Sho-ichi
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Matsuoka
authors.forename: Soichi
authors.initials: S
authors.lastname: Kitano
authors.forename: Nozomu
authors.initials: N
authors.lastname: Hibi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Jinnouchi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Umei
authors.forename: Shuji
authors.initials: S
authors.lastname: Iida
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Takenaka
authors.forename: Takanori
authors.initials: T
authors.lastname: Matsui
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Imaizumi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D008875:Middle Aged; D012044:Regression Analysis; D017678:Sex Distribution; D017539:Tunica Intima / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL