title: Organocatalytic highly enantioselective synthesis of secondary alpha-hydroxyphosphonates.
abstract: [reaction: see text] The first organocatalytic cross aldol reaction of ketones and diethyl formylphosphonate hydrate has been realized by using readily available l-prolinamide as the catalyst. Secondary alpha-hydroxyphosphonates have been synthesized in high enantioselective (up to >99% ee) and good diastereoselectivity.
authors.affiliation: Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249-0698, USA.
authors.forename: Rajasekhar
authors.initials: R
authors.lastname: Dodda
authors.forename: Cong-Gui
authors.initials: CG
authors.lastname: Zhao
mesh_terms: D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D063065:Organophosphonates; D011392:Proline; C056291:prolinamide