title: Pleomorphic CD8+ small/medium size cutaneous T-cell lymphoma.
abstract: Pleomorphic small/medium-sized cutaneous T-cell lymphoma is a recently recognized rare type of cutaneous T-cell lymphoma which is clinicopathologically different from mycosis fungoides and Sezary syndrome. By definition the phenotype of the neoplastic lymphocytes in pleomorphic small/medium-sized cutaneous CD3CD4CD8 but CD8 pleomorphic small/medium sized cutaneous T-cell lymphoma cases have been occasionally described. We describe a 55-year-old female with a pruritic erythematous nodule on the lateral aspect of her right foot present for 1.5 years. Histology revealed a nonepidermotropic lichenoid infiltrate in the papillary dermis and a patchy infiltrate in the mid and lower dermis composed of small to medium-sized pleomorphic lymphocytes. The immunophenotype of these lymphocytes was CD3CD4CD8TIA-1. Staining for CD20, CD30, CD56, TdT, and LMP1 were negative, and the Ki-67 proliferation index was 5% to 10%. Gene rearrangement studies demonstrated a T-cell clone. The laboratory and imaging workup did not reveal extracutaneous involvement. The lesion was treated by local irradiation but a follow-up biopsy demonstrated only partial remission. Consequently, the lesion was treated by surgical excision.
authors.affiliation: Department of Dermatology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel.
authors.forename: Z
authors.initials: Z
authors.lastname: Khamaysi
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Arieh
authors.forename: R
authors.initials: R
authors.lastname: Epelbaum
authors.forename: R
authors.initials: R
authors.lastname: Bergman
mesh_terms: D001706:Biopsy; D016827:CD8 Antigens / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D016827:CD8 Antigens