title: Association of interleukin-8 with hot flashes in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women.
abstract: OBJECTIVE
  The purpose of this study was to identify serum cytokine concentrations in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women with hot flashes.
  
  
  METHODS
  Serum concentrations of 17 cytokines were simultaneously measured using a multiplexed human cytokine assay in 129 premenopausal, perimenopausal, and postmenopausal women and 50 bilateral oophorectomized women.
  
  
  RESULTS
  Serum IL-8 concentrations in midlife women and bilateral oophorectomized women with severe hot flashes were significantly higher than the concentrations in women without hot flashes and women with mild and moderate hot flashes. Serum macrophage inflammatory protein-1beta concentration in women with severe hot flashes was significantly higher than those in women without hot flashes and women with mild and moderate hot flashes.
  
  
  CONCLUSIONS
  Serum IL-8 concentrations in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women with hot flashes were significantly higher than those in women without hot flashes. IL-8 may be associated with peripheral vasodilation in women with hot flashes.
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. yasui@clin.med.tokushima-u.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yasui
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Uemura
authors.forename: Junko
authors.initials: J
authors.lastname: Tomita
authors.forename: Yuka
authors.initials: Y
authors.lastname: Miyatani
authors.forename: Masayo
authors.initials: M
authors.lastname: Yamada
authors.forename: Akira
authors.initials: A
authors.lastname: Kuwahara
authors.forename: Toshiya
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Maegawa
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Yuzurihara
authors.forename: Shuichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
mesh_terms: D000328:Adult; D054407:Chemokine CCL4; D016207:Cytokines / Q000097:blood; D005260:Female; D019584:Hot Flashes / Q000097:blood* / Q000209:etiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood*; D019402:Macrophage Inflammatory Proteins / Q000097:blood; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects; D047648:Perimenopause / Q000097:blood*; D017698:Postmenopause / Q000097:blood*; D017697:Premenopause / Q000097:blood*
chemical_list: D054407:Chemokine CCL4; D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D019402:Macrophage Inflammatory Proteins