title: Use of alarm symptoms to select dyspeptics for endoscopy causes patients with curable esophagogastric cancer to be overlooked.
abstract: BACKGROUND
  In August 2004, the United Kingdom Department of Health advisory body published dyspepsia referral guidelines for primary care practitioners. These guidelines advised empiric treatment with antisecretory medications and referral for endoscopy only in the presence of alarm symptoms. The current study aimed to evaluate the effect of these guidelines on the detection of esophagogastric cancer.
  
  
  METHODS
  The study reviewed a prospectively compiled database of 4,018 subjects who underwent open access gastroscopy during the years 1990 to 1998. The main outcome measures for the study were cancer detection rates, International Union Against Cancer (UICC) stage, and survival.
  
  
  RESULTS
  Gastroscopy identified esophagogastric carcinoma in 123 (3%) of the 4,018 subjects. Of these 123 patients, 104 (85%) with esophagogastric cancer had "alarm" symptoms (anemia, mass, dysphagia, weight loss, vomiting) and would have satisfied the referral criteria. The remaining 15% would not have been referred for initial endoscopic assessment because their symptoms were those of uncomplicated "benign" dyspepsia. The patients with "alarm" symptoms had a significantly more advanced tumor stage (metastatic disease in 47% vs 11%; p < 0.001), were less likely to undergo surgical resection (50% vs 95%; p < 0.001), and had a poorer survival (median, 11 vs 39 months; p = 0.01) than their counterparts without such symptoms.
  
  
  CONCLUSIONS
  The use of alarm symptoms to select dyspeptics for endoscopy identifies patients with advanced and usually incurable esophagogastric cancer. Patients with early curable cancers often have only dyspeptic symptoms, and their diagnosis will be delayed until the symptoms of advanced cancer develop.
authors.affiliation: Northern Oesophago-Gastric Cancer Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Bowrey
authors.forename: S M
authors.initials: SM
authors.lastname: Griffin
authors.forename: J
authors.initials: J
authors.lastname: Wayman
authors.forename: D
authors.initials: D
authors.lastname: Karat
authors.forename: N
authors.initials: N
authors.lastname: Hayes
authors.forename: S A
authors.initials: SA
authors.lastname: Raimes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019992:Databases as Topic; D004415:Dyspepsia / Q000209:etiology*; D016145:Endoscopy, Digestive System; D004938:Esophageal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012017:Referral and Consultation; D013274:Stomach Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology