[Empiric de-escalation strategy of antibiotic treatment].
Nosocomial pneumonia, especially ventilator-acquired pneumonia, has the greatest impact on patients' management in intensive care unit. Inappropriate initial antimicrobial treatment increases attributable and crude mortality from ventilator-acquired pneumonia. De-escalation therapy improves short-term survival of patients with ventilator-acquired pneumonia without increasing the emergence of resistant organisms.
Adukauskiene
Dalia
D
Clinic of Intensive Care, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania. daliaadukauskiene@hotmail.com
Vitkauskiene
Astra
A
D000367:Age Factors; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D002986:Clinical Trials as Topic; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D024881:Drug Resistance, Bacterial; D036262:Empirical Research; D006801:Humans; D007362:Intensive Care Units; D053717:Pneumonia, Ventilator-Associated / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D011446:Prospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality; D013997:Time Factors
D000900:Anti-Bacterial Agents