The significance of peroxisomes in methanol metabolism in methylotrophic yeast.
The capacity to use methanol as sole source of carbon and energy is restricted to relatively few yeast species. This may be related to the low efficiency of methanol metabolism in yeast, relative to that of prokaryotes. This contribution describes the details of methanol metabolism in yeast and focuses on the significance of compartmentalization of this metabolic pathway in peroxisomes.
van der Klei
Ida J
IJ
Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, P.O. Box 14, NL-9750 AA Haren, The Netherlands.
Yurimoto
Hiroya
H
Sakai
Yasuyoshi
Y
Veenhuis
Marten
M
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D019880:Aldehyde-Ketone Transferases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D005557:Formaldehyde / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005979:Glutathione Peroxidase / Q000378:metabolism; D000432:Methanol / Q000378:metabolism*; D020675:Peroxisomes / Q000201:enzymology*; D010843:Pichia / Q000235:genetics / Q000378:metabolism*; D013869:Thiolester Hydrolases / Q000378:metabolism
D005557:Formaldehyde; D000429:Alcohol Oxidoreductases; C019643:alcohol oxidase; D002374:Catalase; D005979:Glutathione Peroxidase; D019880:Aldehyde-Ketone Transferases; C031222:formaldehyde transketolase; D013869:Thiolester Hydrolases; C020149:s-formylglutathione hydrolase; D000432:Methanol