Myelin-associated oligodendrocytic basic protein: a family of abundant CNS myelin proteins in search of a function.
The myelin-associated oligodendrocytic basic protein (MOBP) family constitutes the third most abundant protein in CNS myelin. The mouse Mobp gene comprises eight exons. Mobp pre-mRNA processing gives rise to at least seven Mobp splice variants which are expressed solely in the oligodendrocyte. The predicted proteins all, with one exception, share a 68 residue amino terminus, encoded by exon 3. The carboxyl termini differ in length, giving rise to the diverse array of the protein isoforms. Like myelin basic protein, MOBP is present in the major dense line of CNS myelin suggesting a role in the compaction or stabilization of myelin. However, Mobp homozygous null mice display no overt clinical phenotype and no defect in the process of myelination. MOBP can induce experimental allergic encephalomyelitis in mice and has been proposed to have a role in the pathogenesis of multiple sclerosis. Despite 10 years of rigorous study, the normal physiological function of MOBP remains unknown.
Montague
Paul
P
Applied Neurobiology Group, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK. pm6e@clinmed.gla.ac.uk
McCallion
Andrew S
AS
Davies
R Wayne
RW
Griffiths
Ian R
IR
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism* / Q000648:ultrastructure; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics / Q000378:metabolism; D009103:Multiple Sclerosis / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009185:Myelin Proteins; D009186:Myelin Sheath / Q000378:metabolism* / Q000648:ultrastructure; D018992:Myelin-Associated Glycoprotein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D063308:Myelin-Oligodendrocyte Glycoprotein; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000235:genetics
C560487:MOBP protein, human; C571326:MOG protein, human; C560488:Mobp protein, mouse; C571327:Mog protein, mouse; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D020033:Protein Isoforms