Addiction to apomorphine: a clinical case-centred discussion.
OBJECTIVE
To report the case of a patient, who in the context of an anti-Parkinsonian therapy, developed addiction to apomorphine.


METHODS
Clinical case description.


RESULTS
Apomorphine is a dopaminergic agonist that acts directly on D2 receptors. It has been used in alcoholism, male sexual dysfunction and with diagnostic and therapeutic purposes in Parkinson's disease (PD).


CONCLUSIONS
The present work describes the case of a woman with PD who developed a loss of control over the consumption of apomorphine that resulted in a significant impairment of her functioning. PD patients with high frequency develop different psychiatric symptoms. Conversely, anti-Parkinsonian drugs also generate psychiatric symptoms that can be experienced by the patient as pleasant sensations ('alerting', 'awakening', 'activating', hypomania and hypersexuality). In spite of this, addiction to these drugs in patients with PD is a very rare phenomenon. Currently, the prescription of apomorphine has been extended to patients with erectile dysfunction, which may increase the prevalence of addiction cases or of severe psychiatric symptoms.
Téllez
Carlos
C
Hospital Clínico de la Universidad de Chile, Santiago, Chile. sdiaz@redclinicauchile.cl
Bustamante
M Leonor
ML
Toro
Pablo
P
Venegas
Pablo
P
D000978:Antiparkinson Agents / Q000008:administration & dosage*; D001058:Apomorphine / Q000008:administration & dosage*; D018491:Dopamine Agonists / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009021:Morphine Dependence / Q000209:etiology*; D010300:Parkinson Disease / Q000188:drug therapy*
D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D001058:Apomorphine