title: Acute renal failure associated with vancomycin- and tobramycin-laden cement in total hip arthroplasty.
abstract: OBJECTIVE
  To describe 2 cases of acute renal failure (ARF) associated with the use of antibiotic-laden cement incorporated in total hip arthroplasties (THA).
  
  
  METHODS
  An 82-year-old female received a right THA with antibiotic-laden cement spacers. She developed ARF 5 months following implantation, concurrent with an elevated serum tobramycin concentration of 5.5 microg/mL. After explantation of the prosthesis and spacers, serum creatinine and antibiotic concentrations decreased to within normal limits. A 79-year-old male received antibiotic-laden cement spacers in a revision of his right THA due to infection. ARF developed 1 1/2 months after the revision; a serum tobramycin concentration was 2.9 microg/mL. Serum creatinine and antibiotic serum concentrations decreased to within normal limits with explantation.
  
  
  CONCLUSIONS
  More than 250 000 joint replacements are performed yearly in the US. A common complication is infection, which occurs in 1-2% of primary replacements and 3-4% of revisions of previously infected prostheses. Antibiotic-laden cement is used for prosthesis placement to prevent or treat infection, while minimizing systemic drug exposure. Both patients described here received antibiotic-laden spacers during THA and subsequently developed ARF in conjunction with elevated serum tobramycin concentrations. Use of the Naranjo probability scale and consideration of possible contributing factors suggest a probable association of the antibiotic-laden cement and the development of ARF in these patients.
  
  
  CONCLUSIONS
  Antibiotic-laden cement with aminoglycosides and/or vancomycin has the potential for systemic toxicity and should be used according to guidelines and with increased vigilance and prudent monitoring in patients at increased risk for nephrotoxicity.
authors.affiliation: The University of Montana and Community Medical Center, Missoula, MT 59812-1522, USA.
authors.forename: Benjamin N
authors.initials: BN
authors.lastname: Patrick
authors.forename: Michael P
authors.initials: MP
authors.lastname: Rivey
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Allington
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001843:Bone Cements / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced / Q000175:diagnosis; D014031:Tobramycin / Q000009:adverse effects*; D014640:Vancomycin / Q000009:adverse effects*
chemical_list: D001843:Bone Cements; D014640:Vancomycin; D014031:Tobramycin