title: Therapeutic resistance in lung cancer.
abstract: Despite considerable progress over the last 25 years in the systemic therapy of lung cancer, intrinsic and acquired resistance to chemotherapeutic agents and radiation remains a vexing problem. The number of mechanisms of therapeutic resistance in lung cancer has expanded considerably over the past three decades, and the crucial role of stress resistance pathways is increasingly recognised as a cause of intrinsic and acquired chemo- and radiotherapy resistance. This paper reviews recent evidence for stress defence proteins, particularly RALBP1/RLIP76, in mediating intrinsic and acquired chemotherapy and radiation resistance in human lung cancer.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, 700 Planetarium Place, CPB # 351, 76019-0065, USA. aalok@uta.edu
authors.forename: Aalok
authors.initials: A
authors.lastname: Nadkar
authors.forename: Chirag
authors.initials: C
authors.lastname: Pungaliya
authors.forename: Kenneth
authors.initials: K
authors.lastname: Drake
authors.forename: Ewa
authors.initials: E
authors.lastname: Zajac
authors.forename: Sharad S
authors.initials: SS
authors.lastname: Singhal
authors.forename: Sanjay
authors.initials: S
authors.lastname: Awasthi
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis; D002453:Cell Cycle; D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D019008:Drug Resistance, Neoplasm; D020690:GTPase-Activating Proteins / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000532:radiotherapy*; D011836:Radiation Tolerance
chemical_list: D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D020690:GTPase-Activating Proteins; D036341:Intercellular Signaling Peptides and Proteins; C095637:RALBP1 protein, human; D004247:DNA; D005982:Glutathione Transferase; D005978:Glutathione