Metabolic disturbances in chronic heart failure: a case for the "macho" approach with testosterone?!
Chronic heart failure (CHF) primarily affects the cardiovascular system. In addition, there is strong evidence that CHF is a complex metabolic disorder. Metabolic abnormalities include insulin resistance and lack of anabolic hormone activity. To date there have been few interventional trials targeting insulin sensitivity. A recent study suggests a link between testosterone therapy and improvements in insulin sensitivity, measured using the homeostatic model assessment (HOMA-IR). We discuss this study in detail. Further studies are needed to substantiate this link and to generally explore the value of testosterone therapy in CHF patients.
Lainscak
Mitja
M
Doehner
Wolfram
W
Anker
Stefan D
SD
D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008659:Metabolic Diseases / Q000503:physiopathology*; D013739:Testosterone / Q000627:therapeutic use*
D013739:Testosterone