Transition from molecular chaos to coherent spiking of enzymic reactions in small spatial volumes.
Theoretical study of an irreversible enzymic reaction with allosteric product activation reveals that, in small spatial volumes, it can undergo a transition to coherent spiking regime characterized by the presence of strong correlations between reaction events and the states of individual enzyme molecules.
Hess
B
B
Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany.
Mikhailov
A
A