title: From in vivo to in silico biology and back.
abstract: The massive acquisition of data in molecular and cellular biology has led to the renaissance of an old topic: simulations of biological systems. Simulations, increasingly paired with experiments, are being successfully and routinely used by computational biologists to understand and predict the quantitative behaviour of complex systems, and to drive new experiments. Nevertheless, many experimentalists still consider simulations an esoteric discipline only for initiates. Suspicion towards simulations should dissipate as the limitations and advantages of their application are better appreciated, opening the door to their permanent adoption in everyday research.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Di Ventura
authors.forename: Caroline
authors.initials: C
authors.lastname: Lemerle
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Michalodimitrakis
authors.forename: Luis
authors.initials: L
authors.lastname: Serrano
mesh_terms: D019295:Computational Biology / Q000379:methods* / Q000592:standards / Q000639:trends; D003198:Computer Simulation; D008433:Mathematics; D008954:Models, Biological