title: [A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy].
abstract: We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.
authors.affiliation: Dept. of Surgery, Oita Prefectural Hospital.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Shibahara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hirazuka
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Mizuki
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Kojiro
authors.initials: K
authors.lastname: Mashino
authors.forename: Kyuzo
authors.initials: K
authors.lastname: Fuji
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ikeda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kahno
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D000284:Administration, Oral; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D011788:Quality of Life; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D012007:Rectum / Q000601:surgery*; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C096910:UFT(R) drug; D005641:Tegafur; D014498:Uracil; D002955:Leucovorin