From Mendelian to molecular genetics: the Xiphophorus melanoma model.
In human tumor biopsies it is almost impossible to pinpoint the particular molecular abnormalities that determine neoplasia. In animal models where tumorigenesis is initiated by clearly defined genetic events, it is possible to study the genes and their functions that make a normal cell become a fully malignant cancer cell. In the fish Xiphophorus, melanoma can be initiated by simple crossings, and the signaling pathways that govern tumor growth and progression can be delineated. This model offers the prospect of obtaining a complete picture of the molecular changes and regulatory networks underlying tumor formation, which should contribute to a better understanding of some general principles of cancer biology, and identify new targets for melanoma research in particular.
Meierjohann
Svenja
S
University of Wurzburg, Physiological Chemistry I, Biocenter, D-97074 Wurzburg, Germany.
Schartl
Manfred
M
D000818:Animals; D003532:Cyprinodontiformes / Q000235:genetics* / Q000502:physiology; D004195:Disease Models, Animal; D018450:Disease Progression; D019143:Evolution, Molecular; D029941:Fish Proteins / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D014644:Genetic Variation; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction; D049490:Systems Biology
D029941:Fish Proteins; D020794:Receptor Protein-Tyrosine Kinases; C077101:Xmrk protein, Xiphophorus