Does a kampo medicine containing schisandra fruit affect pharmacokinetics of nifedipine like grapefruit juice?
Herb-drug interaction has attracted attention as medicinal topics recently. However, the drug information is sometimes confusing. Previous in vitro studies revealed that schisandra fruit had strong inhibitory effect on CYP3A4 and claimed the possibilities of its herb-drug interaction. In the present study, we evaluated the inhibitory effects of schisandra fruit and shoseiryuto, an herbal formula in Japanese traditional kampo medicine containing eight herbal medicines including schisandra fruit, on rat CYP3A activity in vitro, and the effect of shoseiryuto on pharmacokinetics of nifedipine in rats, in comparison with those of grapefruit juice, a well-characterized natural CYP3A inhibitor. Shoseiryuto and its herbal constituents, schisandra fruit, ephedra herb and cinnamon bark exhibited in vitro inhibitory effect of CYP3A. Although shoseiryuto inhibited rat CYP3A activity in vitro with a degree comparable to grapefruit juice, shoseiryuto did not significantly affect a plasma concentration profile of nifedipine in rats as grapefruit juice did. These results indicate that in vivo experiments using the extract of herbal medicine prepared with the same dosage form as patients take are necessary to provide proper information about herb-drug interaction.
Makino
Toshiaki
T
Department of Pharmacognosy, Graduate School of Nagoya City University, Tanabe-Dori, Nagoya, Japan. makino@phar.nagoya-cu.ac.jp
Mizuno
Fumika
F
Mizukami
Hajime
H
D000818:Animals; D001628:Beverages; D032083:Citrus paradisi; D065692:Cytochrome P-450 CYP3A Inhibitors; D041743:Herb-Drug Interactions; D008297:Male; D020835:Medicine, Kampo; D009543:Nifedipine / Q000493:pharmacokinetics*; D051381:Rats; D032141:Schisandra
D065692:Cytochrome P-450 CYP3A Inhibitors; D009543:Nifedipine