Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis.
Autoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized by chronic inflammation of the liver. Although the HLA-DRB1*0405 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined. Recently, polymorphisms of Fcgamma receptors (FcgammaR) and Fc receptor-like gene 3 (FCRL3) were linked to a variety of autoimmune diseases, and may be at least partially responsible for susceptibility to AIH. In this study, we genotyped FcgammaRIIA, FcgammaRIIB, and four FCRL3 polymorphisms in 87 Japanese patients with type 1 AIH and 97 ethnically matched controls using the TaqMan assay. Although we were able to detect significantly lower serum IgG concentrations in AIH patients specifically with the FCRL3-110A/A genotype, we observed no difference in the distribution of the genotypes between patients and controls, implying that susceptibility to type 1 AIH in Japanese patients is not influenced by FcgammaRIIA, FcgammaRIIB, or FCRL3 polymorphisms.
Umemura
Takeji
T
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. t-ume@hsp.md.shinshu-u.ac.jp
Ota
Masao
M
Yoshizawa
Kaname
K
Katsuyama
Yoshihiko
Y
Ichijo
Tetsuya
T
Tanaka
Eiji
E
Kawa
Shigeyuki
S
Kiyosawa
Kendo
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D019693:Hepatitis, Autoimmune / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*
D015703:Antigens, CD; C499173:FCGR2B protein, human; C457775:FCRL3 protein, human; C080568:Fc gamma receptor IIA; D017452:Receptors, IgG; D011971:Receptors, Immunologic