title: Utilization study of stems and leaves of Tienchi Ginseng. I. Anti-hypertensive effect of stems and leaves of Tienchi Ginseng on stroke-prone spontaneously hypertensive rat (SHRSP).
abstract: Tienchi ginseng tea was prepared from stems and leaves of Tienchi ginseng which is a special product in China. The increase in systolic blood pressure (SBP) was significantly inhibited by the consumption of a 4% this tea solution as drinking water from the prehypertensive stage (6 weeks of age) in male stroke-prone spontaneously hypertensive rats (SHRSP). A similar intake from the hypertensive stage also showed an anti-hypertensive effect. In contrast, a similar intake had no effect on SBP of normotensive Wistar Kyoto rats. We found that the rhizome of Tienchi ginseng contained two types of saponin: 20(s)-protopanaxadiol (PPD) such as ginsenosides Rb(1) and Rd having a hypotensive effect, and 20(s)-protopanaxatriol (PPT) such as ginsenosides Rg(1) and Re having a hypertensive effect. In contrast, the tea sample contained PPD and gamma-aminobutyric acid (GABA), but no PPT. These results suggest that drinking this tea infusion would be useful for controlling hypertension.
authors.affiliation: R & D, Banjo Foods Co., Ltd, Japan. riceball_2@ybb.ne.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yanai
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Sato
authors.forename: Shuichi
authors.initials: S
authors.lastname: Masuda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ikeda
authors.forename: Naohide
authors.initials: N
authors.lastname: Kinae
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D036145:Ginsenosides / Q000494:pharmacology; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000032:analysis / Q000494:pharmacology; D013662:Tea
chemical_list: D000959:Antihypertensive Agents; D036145:Ginsenosides; D010936:Plant Extracts; D012503:Saponins; D013662:Tea