Primary cutaneous plasmacytoma (posttransplant lymphoproliferative disorder, plasmacytoma-like) in a heart transplant patient.
Extramedullary plasmacytomas in posttransplant patients are rarely encountered. We present the fifth case of a primary cutaneous plasmacytoma (posttransplant lymphoproliferative disorder, plasmacytoma-like) that developed in a heart transplant patient. The tumor presented as a solitary nodule of the skin 10 years after transplantation. It subsequently involved 2 other cutaneous sites and remained confined to the skin for 5 years. The neoplastic cells were Epstein-Barr virus small RNAs (EBER 1,2) positive and EBV-latent membrane protein 1 (LMP 1) negative, corresponding to type I EBV latency. The direct role of EBV in the development of the tumor remains uncertain.
Willoughby
Vickie
V
Department of Pathology, Scott and White Memorial Hospital and Clinic Scott, Sherwood and Brindley Foundation, Temple, Texas 76508, USA.
Werlang-Perurena
Ada
A
Kelly
Ann
A
Francois
Juden
J
Donner
Ludvik R
LR
D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications; D017809:Fatal Outcome; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000009:adverse effects*; D006566:Herpesviridae Infections / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D019394:Ki-67 Antigen / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000032:analysis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D009693:Nucleic Acid Hybridization; D010954:Plasmacytoma / Q000209:etiology / Q000378:metabolism / Q000532:radiotherapy / Q000601:surgery / Q000821:virology; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism / Q000532:radiotherapy / Q000601:surgery / Q000821:virology; D053668:Syndecan-1 / Q000032:analysis; D013997:Time Factors; D016896:Treatment Outcome
D004279:DNA, Viral; D019394:Ki-67 Antigen; D053668:Syndecan-1; D017493:Leukocyte Common Antigens