New immunologic treatments for inflammatory bowel disease.
After many years with little progress in new treatments for patients with inflammatory bowel disease, there is now rapid expansion of a new class of immunologic agents. These agents are designed to disrupt proinflammatory pathways at specific sites. Monoclonal antibodies to tumor necrosis factor-alpha (TNF-alpha) are already transforming the lives of some patients with previously intractable Crohn disease, and further TNF-alpha directed therapies are being developed. Clinical trials are now underway on agents that inhibit adhesion molecules and antiinflammatory cytokines, while attempts are being made to actively immunize against TNF-alpha. Promising data continue to be reported, although long-term safety data are still mostly unavailable. Although these agents are proving to be very effective in the treatment of patients with Crohn disease, their use should continue to be restricted while indications and dose regimens are defined.
Heuschkel
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Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, Massachusetts, USA. Heuschkel@hotmail.com