title: Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detection.
abstract: Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.
authors.affiliation: G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Hunter
authors.forename: Vadim
authors.initials: V
authors.lastname: Backman
authors.forename: Gabriel
authors.initials: G
authors.lastname: Popescu
authors.forename: Maxim
authors.initials: M
authors.lastname: Kalashnikov
authors.forename: Charles W
authors.initials: CW
authors.lastname: Boone
authors.forename: Adam
authors.initials: A
authors.lastname: Wax
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Gopal
authors.forename: Kamran
authors.initials: K
authors.lastname: Badizadegan
authors.forename: Gary D
authors.initials: GD
authors.lastname: Stoner
authors.forename: Michael S
authors.initials: MS
authors.lastname: Feld
mesh_terms: D000465:Algorithms; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002273:Carcinogens; D004867:Equipment Design; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000175:diagnosis*; D004947:Esophagus / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008027:Light; D008403:Mass Screening / Q000379:methods; D015233:Models, Statistical; D009369:Neoplasms / Q000175:diagnosis*; D051381:Rats; D012542:Scattering, Radiation
chemical_list: D014408:Biomarkers, Tumor; D002273:Carcinogens