Effects of interferon-gamma on bone remodeling during experimental tooth movement.
OBJECTIVE
To determine the effects of interferon-gamma (IFN-gamma) on bone remodeling during orthodontic tooth movement.


METHODS
Thirty adult male Sprague Dawley rats were randomly categorized into five groups. IFN-gamma was administered in three different doses (0.01, 0.02, and 0.05 microg/20 microL) and the remaining two groups served as control. Mandibular first molars were moved mesially by means of Ni-Ti closed coil springs in all groups. The results were evaluated histomorphometrically, and parameters of trabecular bone volume (BV/TV), trabecular bone number (Tr.N), and trabecular separation (Tr.Sep) were observed at the interradicular bone area of the mandibular first molars.


RESULTS
Increases in BV/TV and Tr.N and decreases in Tr.Sep revealed the antiosteoclastic activity of IFN-gamma.


CONCLUSIONS
IFN-gamma administration may be useful clinically for anchorage control.
Mermut
Sila
S
Department of Orthodontics, Gulhane Military Medical Academy, Ankara, Turkey.
Bengi
Ali Osman
AO
Akin
Erol
E
Kürkçü
Mehmet
M
Karaçay
Seniz
S
D000818:Animals; D015519:Bone Density; D016723:Bone Remodeling / Q000187:drug effects*; D003799:Dental Stress Analysis; D007371:Interferon-gamma / Q000494:pharmacology* / Q000502:physiology*; D008297:Male; D008334:Mandible; D008963:Molar; D009967:Orthodontic Appliances; D010010:Osteoclasts / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins; D014087:Tooth Movement Techniques / Q000295:instrumentation
D011994:Recombinant Proteins; D007371:Interferon-gamma