In vivo fluorescence diagnostics and photodynamic therapy of gastrointestinal superficial polyps with aminolevulinic acid. A clinical and spectroscopic study.
In the present study initial results of clinical study related to the treatment of patients having different types of precancerous lesions in the area of esophagus, stomach and intestine by photodynamic therapy (PDT) based on aminolevulinic acid (ALA-PDT) are reported. The procedure was performed by laser fibre system with the light guides introduced through biopsy channel of an endoscope. In addition, in vivo fluorescent diagnostics and spectral analyses of biopsies were performed. Each patient had a positive response to therapy. In two cases there was a total response and in other five cases more than sixty percent of suspected area was removed. Additionally, sigilocellular carcinoma of stomach was revealed in one case. It appears from the results of this study, that the treatment of precancerous lesions with ALA-PDT could be successful treatment modality.
Smolka
J
J
International Laser Centre, 81219 Bratislava, Slovak Republic. smolka@ilc.sk
Mateasik
A
A
Cunderlikova
B
B
Sanislo
L
L
Mlkvy
P
P
D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D016099:Endoscopy, Gastrointestinal; D004935:Esophageal Diseases / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011127:Polyps / Q000188:drug therapy / Q000473:pathology; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology; D013272:Stomach Diseases / Q000188:drug therapy / Q000473:pathology
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid