Baclofen-induced suppression of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats exposed to different alcohol concentrations.
This study investigated the effect of the gamma-aminobutyric acid(B) (GABA(B)) receptor agonist, baclofen, on alcohol deprivation effect (the transient increase in alcohol intake occurring after a period of alcohol abstinence) in Sardinian alcohol-preferring (sP) rats exposed to 4 bottles containing water and 10%, 20%, and 30% (v/v) alcohol, respectively. Acute administration of baclofen (1 mg/kg, i.p.) suppressed both aspects of alcohol deprivation effect: the extra-intake of alcohol and the selection of the highest concentrated alcohol solution. These results suggest that the GABA(B) receptor is part of the neural substrate mediating alcohol deprivation in sP rats.
Colombo
Giancarlo
G
C.N.R. Institute of Neuroscience, Cagliari, Italy. colomb@unica.it
Serra
Salvatore
S
Vacca
Giovanni
G
Carai
Mauro A M
MA
Gessa
Gian Luigi
GL
D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology*; D008297:Male; D051381:Rats; D018080:Receptors, GABA-B / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control* / Q000523:psychology
D002492:Central Nervous System Depressants; D018755:GABA Agonists; D018080:Receptors, GABA-B; D000431:Ethanol; D001418:Baclofen