title: Triterpenoid saponins from Lysimachia davurica.
abstract: Three new saponins were isolated from the whole plants of Lysimachia davurica. On the basis of 1D and 2D NMR ((1)H-(1)HCOSY, HMBC, HMQC, and TOCSY) techniques, MS, and hydrolysis, their structures were found to be 3-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-glucopyranosyl-(1-->4)]-alpha-L-arabinopyranosyl-13,28-epoxy-3beta-hydroxy-16-oleanaone (1), 3-O-beta-D-glucopyranosyloxyuronic acid-(1-->2)-beta-D-xylopyranosyl-cyclamiretin A (2), and 3-O-beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-cyclamiretin A (3), respectively. Compounds 2 and 3 showed significant cytotoxicities against human A-2780 cells.
authors.affiliation: Department of Chinese Medicine Science and Engineering, Zhejiang University, Hangzhou, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.forename: Jing-Kui
authors.initials: JK
authors.lastname: Tian
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Xu
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Yang
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D029623:Primulaceae / Q000737:chemistry*; D012015:Reference Standards; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D012503:Saponins; D014315:Triterpenes