title: Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy.
abstract: OBJECTIVE
  The use of medicinal plants for the treatment of human diseases has increased worldwide. Many of them are used by oral administration and, after absorption, may affect many organs. Therefore, this study aimed at assessing the effects of the aqueous extract of Sida cordifolia leaves, popularly known in Brazil as "malva-branca", on liver regeneration.
  
  
  METHODS
  Twenty rats were divided into four groups: control, Sida100, Sida200 and Sida400 groups. All animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of Sida cordifolia, respectively. Immediately after this, they underwent 67% partial hepatectomy. Twenty four hours later, their livers were removed. Hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) using the PC-10 monoclonal antibody.
  
  
  RESULTS
  Sida100 and Sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively).
  
  
  CONCLUSIONS
  The aqueous extract of Sida cordifolia stimulates liver regeneration after 67% partial hepatectomy in rats.
authors.affiliation: Department of Medicine, Federal University of Sergipe, Brazil.
authors.forename: Renata Lemos
authors.initials: RL
authors.lastname: Silva
authors.forename: Gustavo Barreto de
authors.initials: GB
authors.lastname: Melo
authors.forename: Valdinaldo Aragão de
authors.initials: VA
authors.lastname: Melo
authors.forename: Angelo Roberto
authors.initials: AR
authors.lastname: Antoniolli
authors.forename: Paulo Roberto Teixeira
authors.initials: PR
authors.lastname: Michellone
authors.forename: Sérgio
authors.initials: S
authors.lastname: Zucoloto
authors.forename: Maria Aparecida Neves Cardoso
authors.initials: MA
authors.lastname: Picinato
authors.forename: Clarice Fleury Fina
authors.initials: CF
authors.lastname: Franco
authors.forename: Gustavo de Assis
authors.initials: Gde A
authors.lastname: Mota
authors.forename: Orlando de Castro e
authors.initials: Ode C
authors.lastname: Silva
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006498:Hepatectomy; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D019660:Malvaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D018809:Proliferating Cell Nuclear Antigen; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
chemical_list: D010936:Plant Extracts; D028321:Plant Preparations; D018809:Proliferating Cell Nuclear Antigen