CD95-mediated signals in the skin: going out with an (inflammatory) bang?
The death ligand CD95L (Fas/Apo-1-ligand) has been viewed as a proapoptotic molecule involved in the pathogenesis of T cell-mediated skin diseases including eczema. In the presence of inhibitors of caspases, CD95L induces proinflammatory genes in keratinocytes. This more pleiotropic function of CD95L as enhancer of inflammation may be equally important to apoptosis induction of keratinocytes, at least in eczema.
Leverkus
Martin
M
Laboratory for Experimental Dermatology, Department of Dermatology and Venerology, Otto von Guericke University of Magdeburg, Magdeburg, Germany. leverkus@medizin.uni-magdeburg.de
Trautmann
Axel
A
D017209:Apoptosis / Q000276:immunology*; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D003872:Dermatitis / Q000276:immunology*; D004485:Eczema / Q000276:immunology*; D053222:Fas Ligand Protein / Q000502:physiology*; D006801:Humans; D015603:Keratinocytes / Q000276:immunology / Q000473:pathology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology; D019014:fas Receptor / Q000502:physiology*
D061945:Caspase Inhibitors; D053222:Fas Ligand Protein; D019014:fas Receptor; D020169:Caspases