Minireview: expression and function of golli protein in immune system.
In this minireview, the author briefly reviews the development of our understanding on the immunological function of golli proteins. In the immune system, in addition to serving as autoantigens, golli proteins have been recently found to regulate T-cell activation directly, thus modulating EAE induction. The evidence that golli proteins function as signal molecules is summarized.
Feng
Ji-Ming
JM
Semel Institute of Neuroscience, UCLA Geffen School of Medicine, Neuroscience Research Building Room 304, 635 Charles Young Drive, Los Angeles, CA 90095-7332, USA. jfeng@mednet.ucla.edu
D000595:Amino Acid Sequence; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics* / Q000276:immunology
C499048:MBP protein, human; C499047:Mbp protein, mouse; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins; D014157:Transcription Factors