Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages.
Lung surfactant protein D (SP-D) binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination, reduced uptake, and inhibition of growth in human macrophages. Here we show that SP-D limits the intracellular growth of bacilli in macrophages by increasing phagosome-lysosome fusion but not by generating a respiratory burst.
Ferguson
J Scott
JS
Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, N-1147 Doan Hall, 410 W. 10th Avenue, Columbus, OH 43210, USA.
Martin
Jennifer L
JL
Azad
Abul K
AK
McCarthy
Travis R
TR
Kang
Peter B
PB
Voelker
Dennis R
DR
Crouch
Erika C
EC
Schlesinger
Larry S
LS
D000818:Animals; D006801:Humans; D008247:Lysosomes / Q000276:immunology / Q000382:microbiology* / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology* / Q000648:ultrastructure; D008561:Membrane Fusion; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D010587:Phagocytosis; D010588:Phagosomes / Q000276:immunology / Q000382:microbiology* / Q000648:ultrastructure; D037663:Pulmonary Surfactant-Associated Protein D / Q000494:pharmacology*; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology; D016897:Respiratory Burst
D037663:Pulmonary Surfactant-Associated Protein D; D011994:Recombinant Proteins