Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones.
The catalytic asymmetric 1,2-addition of a series of arylboronic acids to 2,2,2-trifluoroacetophenones is described with high isolated yields (up to 96%) and good enantioselectivities (up to 83% ee) using a rhodium(I)/phosphoramidite catalyst.
Martina
Sébastien L X
SL
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Jagt
Richard B C
RB
de Vries
Johannes G
JG
Feringa
Ben L
BL
Minnaard
Adriaan J
AJ