Antibodies with infinite affinity: origins and applications.
Antibodies with infinite affinity were developed with the aim of improving targeted delivery of metal complexes to sites of disease. This is part of a series of chemical technology developments for biomedical imaging and therapy. Using a combination of genetics and chemical synthesis, it addresses challenges in developing proteins that specifically bind synthetic molecules and do not release them. The result is a set of reagents that promise to capture any of a large variety of metallic elements under physiological conditions and hold them for long periods of time.
Butlin
Nathaniel G
NG
Chemistry Department, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Meares
Claude F
CF
D000818:Animals; D000906:Antibodies / Q000737:chemistry* / Q000235:genetics; D002614:Chelating Agents / Q000737:chemistry; D006801:Humans; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy
D000906:Antibodies; D002614:Chelating Agents; D008670:Metals