title: [Problems of prevalance and resistance of nosocomial Klebsiella pneumonia in hospitals of Russia].
abstract: Prevalence of Klebsiella pneumoniae among gramnegative pathogens of nosocomial infections in intensive care units of 33 hospitals of 22 towns in Russia was investigated. Antibiotic susceptibility and extended-spectrum beta-lactamase production were tested in 420 nosocomial K. pneumoniae isolates. Carbapenems (imipenem, meropenem and ertapenem) showed the highest activity. Extended-spectrum beta-lactamase production based on the phenotyping methods was revealed in 342 (81.4%) isolates. The maximum activity against the K. pneumoniae isolates producing extended-spectrum beta-lactamase was observed in imipenem and meropenem (no unsusceptible strains were isolated). 3.2% of the isolates was not susceptible to ertapenem. Differences in the activity of cefoperazone/sulbactam, amikacin, ciprofloxacin and levofloxacin against the extended-spectrum beta-lactamase producing isolates in various hospitals were recorded.
authors.forename: E L
authors.initials: EL
authors.lastname: Riabkova
authors.forename: G K
authors.initials: GK
authors.lastname: Reshed'ko
authors.forename: E D
authors.initials: ED
authors.lastname: Agapova
authors.forename: I A
authors.initials: IA
authors.lastname: Aleksandrova
authors.forename: N V
authors.initials: NV
authors.lastname: Beloborodova
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Vostrikova
authors.forename: D E
authors.initials: DE
authors.lastname: Zdzitovetskiĭ
authors.forename: S F
authors.initials: SF
authors.lastname: Ivanova
authors.forename: V N
authors.initials: VN
authors.lastname: Il'ina
authors.forename: N E
authors.initials: NE
authors.lastname: Marusina
authors.forename: I G
authors.initials: IG
authors.lastname: Multykh
authors.forename: S V
authors.initials: SV
authors.lastname: Polikarpova
authors.forename: S V
authors.initials: SV
authors.lastname: Skal'skiĭ
authors.forename: T N
authors.initials: TN
authors.lastname: Suborova
authors.forename: I A
authors.initials: IA
authors.lastname: Toropova
authors.forename: V B
authors.initials: VB
authors.lastname: Turkutiukov
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006761:Hospitals; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D012426:Russia; D001618:beta-Lactamases / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases