title: [Cognitive deficits in patients with chronic obstructive pulmonary disease (COPD)].
abstract: BACKGROUND
  Patients with COPD present with impairments of their cognitive performance. The present study compares intelligence and memory performance as well as different aspects of attention in COPD patients and healthy controls. Additionally, potential factors influencing daytime performance are analyzed.
  
  
  METHODS
  Neuropsychological testing was performed in 32 patients with COPD and 10 normal controls. The following aspects were evaluated: memory, intelligence, simple, selective and divided attention, sustained attention under stress and under monotonous conditions.
  
  
  RESULTS
  There were no differences between COPD patients and normals with regard to divided attention, vigilance and memory. Patients with COPD demonstrated significantly worse results in terms of intelligence (p < 0.01) as well as simple (p < 0.01), selective (p < 0.05) and sustained attention (p < 0.01). No correlation existed between the severity of the disease (lung function, blood gas analysis, nocturnal oxygen saturation) and neuropsychological findings. Merely a relationship between memory function and slow-wave sleep or REM sleep was demonstrated.
  
  
  CONCLUSIONS
  Impairments of cognitive performance in patients with COPD cannot be predicted on the basis of the severity of the disease. Therefore neuropsychological testing is recommended, especially when impairment of daytime function has to be quantified.
authors.affiliation: Berufsgenossenschaftliche Kliniken Bergmannsheil, Universitätsklinik, Klinikum der Ruhr-Universität Bochum, Medizinische Klinik III, Pneumologie, Allergologie, Schlaf- und Beatmungsmedizin. maritta.orth@rub.de
authors.forename: M
authors.initials: M
authors.lastname: Orth
authors.forename: S
authors.initials: S
authors.lastname: Kotterba
authors.forename: K
authors.initials: K
authors.lastname: Duchna
authors.forename: W
authors.initials: W
authors.lastname: Widdig
authors.forename: K
authors.initials: K
authors.lastname: Rasche
authors.forename: G
authors.initials: G
authors.lastname: Schultze-Werninghaus
authors.forename: H-W
authors.initials: HW
authors.lastname: Duchna
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000453:epidemiology*; D006801:Humans; D007360:Intelligence; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000523:psychology*; D012016:Reference Values