title: Treatment of chronic osteomyelitis with one-stage allograft.
abstract: OBJECTIVE
  To avoid disadvantages of two-stage cancellus bone autograft, we investigated the feasibility of one-stage allograft for reconstructing the bone defect resulting from debridement of chronic osteomyelitis in limbs.
  
  
  METHODS
  Between Feb. 1999 and Apr. 2004, 35 cases of chronic osteomyelitis (8 cases of nonunion) underwent one-stage allograft after debridement in our hospital.
  
  
  RESULTS
  Thirty-five cases were followed up for an average period of 28 months (range, 13 to 55 months), in which 32 cases (91.43%) were found no infection, and 3 cases (8.57%) were confirmed recurrence of infection. Four out of 8 cases of bone nonunion healed in 9.5 months on average (range, 3 to 12 months), and another case also acquired union after redebridement and autograft of ilium due to infection recurrence 35 days after surgery. Renonunion occurred in 3 cases, 2 out of whom healed after secondary operation with autograft. One case of renonunion and 2 cases of infection recurrence refused further treatment.
  
  
  CONCLUSIONS
  A high rate of infection arrest can be attained when one-stage allograft is used to reconstruct the bone defect of chronic osteomyelitis after debridement in limbs. Therefore, chronic osteomyelitis should not be regarded as a contraindication to one-stage allogeneic bone grafting. Renonuion, however, achieves a relatively high rate, especially in cases of segmental bone defect.
authors.affiliation: Department of Orthopedics, General Hospital, Nanjing Unit of PLA, Nanjing 210002, China. tianyazhichi@vip.sina.com
authors.forename: Wei-ju
authors.initials: WJ
authors.lastname: Lu
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Ni-rong
authors.initials: NR
authors.lastname: Bao
authors.forename: Hong-bo
authors.initials: HB
authors.lastname: Qian
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Zeng
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Jian-ning
authors.initials: JN
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003646:Debridement; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000601:surgery*; D014184:Transplantation, Homologous