title: [Subtle skin lesions in the midline as an indication of a neurodermal closing defect].
abstract: Three patients, aged 2, 2.5 and 24 years, presented with a skin lesion in the median or paramedian area at the nose, in the lumbar region and between the shoulders, respectively. The first patient suffered from recurrent infection, the skin lesion of the second patient was a coincidental finding, and the third patient had cosmetic problems. Although there were no signs of neurological deficits, neurodermal closing defects were found by MRI. Two patients underwent surgery to prevent infection and neurological complaints in the future. It is stressed that even if there are no neurological signs or infections, congenital dermal lesions situated in the midline should be considered as possible neural tube defects and therefore analysed by MRI. Ifa neurodermal dysraphism is found, patients should be referred to a neurosurgical centre. A good clinical assessment of the neural lesion, clinical signs and age will determine whether surgical resection is indicated to prevent or resolve neurological problems, infections or cosmetic complaints.
authors.affiliation: Academisch Medisch Centrum/Universiteit van Amsterdam. f.e.bleeker@amc.uva.nl
authors.forename: F E
authors.initials: FE
authors.lastname: Bleeker
authors.forename: W R
authors.initials: WR
authors.lastname: van Furth
authors.forename: C M A M
authors.initials: CM
authors.lastname: van der Horst
authors.forename: C B L M
authors.initials: CB
authors.lastname: Majoie
authors.forename: R W
authors.initials: RW
authors.lastname: Koot
mesh_terms: D000328:Adult; D002675:Child, Preschool; D062109:Dermatologic Surgical Procedures; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009436:Neural Tube Defects / Q000150:complications / Q000473:pathology; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery