title: Synthesis of bisdesmosidic kryptogenyl saponins using the 'random glycosylation' strategy and evaluation of their antitumor activity.
abstract: A bisdesmosidic steroidal saponins library, composed of 16 novel kryptogenin glycosides, was set up via six random glycosylation procedures, wherein two compounds showed their antitumor activity against HeLa cell in the preliminary pharmacological research.
authors.affiliation: Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhao
authors.forename: Xue-Hua
authors.initials: XH
authors.lastname: Lu
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Ke
authors.forename: Ling
authors.initials: L
authors.lastname: Leng
authors.forename: Mao-Sheng
authors.initials: MS
authors.lastname: Cheng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry; D006031:Glycosylation; D006367:HeLa Cells; D006801:Humans; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D012503:Saponins; D013256:Steroids