title: Pharmacokinetics of inhaled anesthetics in green iguanas (Iguana iguana).
abstract: OBJECTIVE
  To test the hypothesis that differences in anesthetic uptake and elimination in iguanas would counter the pharmacokinetic effects of blood:gas solubility and thus serve to minimize kinetic differences among inhaled agents.
  
  
  METHODS
  6 green iguanas (Iguana iguana).
  
  
  METHODS
  Iguanas were anesthetized with isoflurane, sevoflurane, or desflurane in a Latin-square design. Intervals from initial administration of an anesthetic agent to specific induction events and from cessation of administration of an anesthetic agent to specific recovery events were recorded. End-expired gas concentrations were measured during anesthetic washout.
  
  
  RESULTS
  Significant differences were not detected for any induction or recovery events for any inhalation agent in iguanas. Washout curves best fit a 2-compartment model, but slopes for both compartments did not differ significantly among the 3 anesthetics.
  
  
  CONCLUSIONS
  Differences in blood:gas solubility for isoflurane, sevoflurane, and desflurane did not significantly influence differences in pharmacokinetics for the inhalation agents in iguanas.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Brosnan
authors.forename: Bruno H
authors.initials: BH
authors.lastname: Pypendop
authors.forename: Linda S
authors.initials: LS
authors.lastname: Barter
authors.forename: Michelle G
authors.initials: MG
authors.lastname: Hawkins
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics; D000818:Animals; D000077335:Desflurane; D005260:Female; D006207:Half-Life; D007076:Iguanas / Q000378:metabolism*; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D008297:Male; D008738:Methyl Ethers / Q000493:pharmacokinetics*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane