New evaluation therapies for sepsis.
This article presents an analysis of the literature of the last 2 years on the treatment of sepsis and septic shock. It appears that most of the antimediator therapies applied in phase II or III clinical trials yielded disappointing results. But, many other therapeutic approaches are proposed or are ongoing, and many papers report critical analysis of the reasons for the lack of success of past clinical trials.
Deby-Dupont
G
G
Department of Anaesthesiology and Intensive Care, University Hospital, B 35, and Centre for Oxygen Research and Development (CORD), Institut de Chimie, B6a, Domaine Universitaire du Sart Tilman, 4000 Liège, Belgium.
Damas
P P
PP
Lamy
M
M