The use of desmopressin in the management of nocturnal enuresis in patients with spinal cord injury.
OBJECTIVE
The aim of this study is to evaluate the use of desmopressin acetate (DDAVP) in the management of nocturnal enuresis in patients with spinal cord injury (SCI), as well as arginine vasopressin (AVP) daily production, urine output, urine osmolarity and clean intermittent catheterization (CIC) before and after the use of desmopressin.


METHODS
We studied 11 patients with SCI (7 men 4 women). All patients attended a rehabilitation program and used a wheelchair for locomotion. To improve bladder function and achieve socially acceptable continence all patients were placed on a regimen of anticholinergic drugs (oxybutynin 5 mg, 1x3 daily), evening antibiotic prophylaxis and CIC. The subjects were also on night CIC in order to avoid nocturnal incontinence. DDAVP was given intranasally (20 mg before bedtime) in association with other standard therapy. Urine samples were collected under sterile conditions from all patients at 6:00 a.m. and 6:00 p.m. Urine volume was measured and the amount of urine per hour was calculated. Blood samples were also taken to measure serum AVP, urea, creatinine and serum electrolyte.


RESULTS
Our data suggest that nocturnal polyuria in SCI patients occurs due to a lack of diurnal variation of antidiuretic hormone (ADH) secretion. The use of desmopressin produced a statistically significant increase in urine production rate during the day (56.2 vs 81.2 mL/h, P<0.001) and a decrease in nocturnal urine production (59.2 vs 27.7 mL/h, P<0.001). Desmopressin treatment reflects also on urine osmolarity, which did not change during the day (496 vs 489 mOsm/mL, P>0.5) but showed a significant increase during the night (385 vs 862 mOsm/mL, P<0.001). There was a significant decrease in night CIC. No serious adverse effects were observed.


CONCLUSIONS
Our results suggest that desmopressin administration is an beneficial treating option for patients with SCI when fluid restriction and other preventive measures are not able to control abnormal nocturnal polyuria.
Zahariou
A
A
Urology Department, Elpis Hospital, Volos, Greece. zahariou@otenet.gr
Karagiannis
G
G
Papaioannou
P
P
Stathi
K
K
Michail
X
X
D000328:Adult; D050034:Antidiuretic Agents / Q000627:therapeutic use*; D001127:Arginine Vasopressin / Q000097:blood; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D053206:Nocturnal Enuresis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D009994:Osmolar Concentration; D013119:Spinal Cord Injuries / Q000097:blood / Q000150:complications*; D016896:Treatment Outcome; D014546:Urinary Catheterization / Q000706:statistics & numerical data; D014556:Urine
D050034:Antidiuretic Agents; D001127:Arginine Vasopressin; D003894:Deamino Arginine Vasopressin