Novel strategies for treating candidiasis.
In this review the recent achievements in the field of chemotherapy and immunotherapy of candidiasis are outlined. The current limitations of chemotherapeutic approaches and the lack of well defined preventive tools and strategies make it imperative to exploit the potential of novel immunotherapeutic venues. In this prospect the rather extensive work performed on cytokine patterns in experimental models and the upsurge of antibodies as one mechanism of anti-Candida protection raises great promise for the clinical use of immunotherapy possibly in conjunction with chemotherapy to improve the fight against this increasingly prevalent human opportunistic infection.
Polonelli
L
L
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Parma, Parma, Italy. lucpol@iptuniv.cce.unipr.it
Cassone
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