[The value of 99mTc-DX105 cervical lymphatic imaging in detecting cervical lymph node metastasis of laryngeal and hypopharyngeal carcinoma].
OBJECTIVE
To study the value of single photon emission-computed tomography (SPECT) lymphatic imaging by percutaneous injection of 99mTc-DX105 in detecting cervical lymph node metastasis of laryngeal and hypopharyngeal carcinoma.


METHODS
One-three days before the operation, 185MBq 99mTc-DX105 was injected via bilateral mastoids portion percutaneously in each of 30 patients with laryngeal and hypopharyngeal carcinoma, and thus SPECT lymphatic imaging was conducted. Then, the diagnostic result was compared with those of pathological examination of neck dissection specimens.


RESULTS
In SPECT lymphatic imaging of 53 sides neck of 30 patients, 24 sides cervical lymph node were positive, and 3 sides were false positive; 29 sides cervical lymph node were negative, and 1 side was false negative, Sensitivity, specificity and accuracy of SPECT lymphatic imaging were 95.5% (21/22), 90.3% (28/31) and 92.5% (49/53) respectively. Among the 8 sides cervical lymph node metastasis which were false negative by clinical palpation, 7 sides were positive by SPECT lymphatic imaging.


CONCLUSIONS
It is suggested that SPECT lymphatic imaging by percutaneous injection of 99mTc-DX105 in detecting cervical lymph node metastasis of laryngeal and hypopharyngeal carcinoma is pretty valuable for guiding clinical neck node dissection.
Ma
Lianshan
L
Department of Otorhinolaryngology, Weifang City People's Hospital, Weifang 261041, China. entmls@163.com
Han
Zaiwen
Z
Li
Fengqi
F
Liu
Liting
L
Liu
Qingming
Q
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals