title: Improvement of diagnostic accuracy and screening conditions with liquid-based cytology.
abstract: The aim of this population-based study was to compare the histological follow-up diagnoses of cervicocytological neoplasia (dysplasia, carcinoma in situ and carcinoma) in conventional Papanicolaou (CP) smear and ThinPrep PapTest samples (TP). All cytological samples from the County of Funen, Denmark, in the periods 2000 (n = 34,832) and 2002 (n = 29,995) were included in the study. In 2000 and 2002, the specimens were CP and TP, respectively. The detection rate of > or = mild dysplasia was 0.8% in CP and 1.4% in TP, showing a 75% increase in TP when compared with CP (p < 0.001). Histological follow-up of > or = moderate dysplasia revealed a neoplastic lesion in 77.1% and 87.9% in CP and TP, respectively (P < 0.001). The present study indicates that the diagnostic accuracy of cervical cytology is improved with liquid-based cytology. In addition, we focus on the optimized cellular material that shows the diagnostic details very clearly to the microscopist and leads to radically improved screening conditions.
authors.affiliation: Department of Pathology, Odense University Hospital, Winsloewparken 15, 5000 Odense C, Denmark. doris.schledermann@ouh.fyns-amt.dk
authors.forename: Doris
authors.initials: D
authors.lastname: Schledermann
authors.forename: Dorthe
authors.initials: D
authors.lastname: Ejersbo
authors.forename: Berit
authors.initials: B
authors.lastname: Hoelund
mesh_terms: D000328:Adult; D000368:Aged; D003584:Cytological Techniques / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D065006:Papanicolaou Test; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears