title: Bradykinin B2 receptor antagonism with LF 18-1505T reduces brain edema and improves neurological outcome after closed head trauma in rats.
abstract: BACKGROUND
  We evaluated the effect of LF 18-1505T, a novel nonpeptide bradykinin type-2 receptor antagonist, on brain edema and neurologic severity score (NSS) after closed head trauma (CHT).
  
  
  METHODS
  There were 132 rats anesthetized and assigned for sham or CHT; infusion of saline or LF 18-1505T (0.3, 1, 3, 10, or 30 microg x kg x min); and determination of neurologic outcome (brain water content and NSS) or physiologic variables (blood pressure, glucose concentration, etc.).
  
  
  RESULTS
  Post-CHT brain water content was less with LF 18-1505T doses of 3 and 10 microg x kg x min (80.1 +/- 3.8 through 81.6 +/- 2.6%, mean +/- SD) than in the untreated group (84.6 +/- 1.9%, p < 0.01). Post-CHT NSS improved with doses of 3, 10, and 30 microg x kg x min (median, 7; range, 0-12 through median, 10; range, 8-18) as compared with that in the untreated group (median, 17; range, 14-23; p < 0.05). LF 18-1505T with or without CHT did not significantly alter physiologic variables.
  
  
  CONCLUSIONS
  LF 18-1505T decreased brain edema and improved neurologic status after CTH in rats without significantly altering physiologic values.
authors.affiliation: Division of Anesthesiology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Ivashkova
authors.forename: Albert
authors.initials: A
authors.lastname: Svetnitsky
authors.forename: Olga
authors.initials: O
authors.lastname: Mayzler
authors.forename: Didier
authors.initials: D
authors.lastname: Pruneau
authors.forename: Mony
authors.initials: M
authors.lastname: Benifla
authors.forename: Yulia
authors.initials: Y
authors.lastname: Fuxman
authors.forename: Avi
authors.initials: A
authors.lastname: Cohen
authors.forename: Alan A
authors.initials: AA
authors.lastname: Artru
authors.forename: Yoram
authors.initials: Y
authors.lastname: Shapira
mesh_terms: D000818:Animals; D065094:Bradykinin B2 Receptor Antagonists; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D016489:Head Injuries, Closed / Q000150:complications / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D065094:Bradykinin B2 Receptor Antagonists