Characterization of the disposition of lutein after i.v. administration to rats.
Lutein is a carotenoid that has antioxidant effects. Although lutein has received much attention recently due to its antioxidant activities, little information about the pharmacokinetic properties of lutein is available. The disposition of lutein after i.v. administration has not been investigated because lutein is now used as a supplement. The present study was undertaken to acquire additional data on the disposition of lutein after i.v. administration. After i.v. administration, lutein is preferentially distributed to the liver, spleen and lung. Intravenous administration of lutein may provide effective antioxidant activities in these tissues, not only the eye. The results of this study should provide valuable data for drug development.
Itagaki
Shirou
S
Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, sapporo, Japan.
Ogura
Wakako
W
Sato
Yuki
Y
Noda
Toshihiro
T
Hirano
Takeshi
T
Mizuno
Satoshi
S
Iseki
Ken
K
D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D014975:Lutein / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D000975:Antioxidants; D014975:Lutein