[Effect of interleukin-2 on apoptosis and function of human lymphocytes in in-vitro cytostatics culture].
In vitro experiments were conducted to determine the impact of interleukin-2 (IL-2) on apoptosis and function of cytostatic-cultured lymphoid (mononuclear) cells (MNC) of peripheral blood from healthy subjects and children with cancer. Neither slight or any effect on vepesid-16 or carboplatin--cultured MNC apoptosis, nor any phytohemagglutinin--induced proliferation was found. By contrast, in carboplatin- cultured MNC from healthy subjects, IL-2 significantly potentiated their toxicity for tumor cells by producing interferon-gamma. It was concluded that IL-2 predominantly supported MNC functional activity rather than inhibited lymphoid MNC apoptosis in in vitro culture with cytostatic drugs.
Potapnev
M P
MP
Vashkevich
E P
EP
Savitskiĭ
V P
VP
Belevtsev
M V
MV
Ismail-zade
R S
RS
Konoplia
N E
NE
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D016190:Carboplatin / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D005047:Etoposide / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D007376:Interleukin-2 / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000469:parasitology* / Q000502:physiology; D008297:Male
D007376:Interleukin-2; D005047:Etoposide; D016190:Carboplatin