Kinetic resolution of propargylic alcohols catalyzed by benzotetramisole.
[reaction: see text] Kinetic resolution of variously substituted secondary propargylic alcohols catalyzed by benzotetramisole (BTM) proceeds with selectivity factors up to 32, the highest ever achieved with nonenzymatic catalysts for this class of substrates.
Birman
Vladimir B
VB
Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, Missouri 63130, USA. birman@wustl.edu
Guo
Lei
L
D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D007700:Kinetics; D015394:Molecular Structure; D013773:Tetramisole / Q000031:analogs & derivatives* / Q000737:chemistry
D000438:Alcohols; C515434:benzotetramisole; D013773:Tetramisole