The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.
Sánchez-Pedregal
Víctor M
VM
Abteilung NMR-basierte Strukturbiologie, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen, Germany.
Kubicek
Karel
K
Meiler
Jens
J
Lyothier
Isabelle
I
Paterson
Ian
I
Carlomagno
Teresa
T
D000473:Alkanes / Q000737:chemistry* / Q000378:metabolism*; D002219:Carbamates / Q000737:chemistry* / Q000378:metabolism*; D034261:Epothilones / Q000737:chemistry* / Q000378:metabolism; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011485:Protein Binding; D011753:Pyrones / Q000737:chemistry* / Q000378:metabolism*; D012996:Solutions / Q000737:chemistry; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
D000473:Alkanes; D002219:Carbamates; D034261:Epothilones; D007783:Lactones; D011753:Pyrones; D012996:Solutions; D014404:Tubulin; C071229:discodermolide