Humoral immune response and immunoglobulin G Fc receptor genotype are associated with better clinical outcome following idiotype vaccination in follicular lymphoma patients regardless of their response to induction chemotherapy.
We have reported that anti-idiotype antibody response and FcgammaRIIIa 158 valine/valine (V/V) genotype both correlate with better outcome in a group of 136 follicular lymphoma patients receiving idiotype vaccination after induction chemotherapy. Here, we examined whether this correlation is related in any way to the chemotherapy response. In patients with complete response (CR), the 5-year progression-free survival (PFS) was 69% for patients with antibody response and/or V/V genotype, while the PFS was only 40% for patients with neither; the median time to progression (TTP) was 10.47 versus 3.46 years (P=.012). In patients with partial response (PR), the 5-year PFS was 57% for patients with antibody response and/or V/V genotype, and 17% for patients with neither; the median TTP was not reached versus 1.31 years (P=.001). This study further confirms the strong association of clinical outcome with antibody response and with the functionally more active form of the Fc receptor in patients receiving idiotype vaccination regardless of their response to induction chemotherapy.
Weng
Wen-Kai
WK
Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305-5306, USA. wkweng@stanford.edu
Czerwinski
Debra
D
Levy
Ronald
R
D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D000917:Antibody Formation; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018572:Disease-Free Survival; D005838:Genotype; D007074:Immunoglobulin G; D008224:Lymphoma, Follicular / Q000276:immunology* / Q000401:mortality / Q000628:therapy*; D016016:Proportional Hazards Models; D011961:Receptors, Fc / Q000235:genetics*; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome; D014611:Vaccination
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D011961:Receptors, Fc