Effect of improved nutrition during calfhood on serum metabolic hormones, gonadotropins, and testosterone concentrations, and on testicular development in bulls.
The objective of the present study was to evaluate the effects of improved nutrition during calfhood on serum metabolic hormones, gonadotropins and testosterone concentrations, and on sexual development in bulls. Bulls received high (n=17) or control nutrition (n=16) diets from 10 to 30 week of age and the same control nutrition diet from 31 to 74 week of age. Improved nutrition during calfhood resulted in a more sustained period of elevated LH secretion (pulse frequency and total secretion in 10h) during the early gonadotropin rise. GnRH-stimulated LH secretion was not affected by diet, indicating that pituitary responsiveness was not altered; therefore, improved nutrition had direct effects on GnRH secretion by the hypothalamus. Insulin and insulin-like growth factor-I (IGF-I) concentrations were greater during calfhood in bulls receiving high nutrition, indicating that these metabolic hormones might be involved in regulating GnRH and LH secretion. Improved nutrition also resulted in increased testosterone secretion that was associated with greater circulating IGF-I concentrations, suggesting a role for this metabolic hormone in regulating Leydig cell number and function. Furthermore, improved nutrition during calfhood resulted in greater testicular weight and sperm production in mature bulls, indicating that increased LH secretion during calfhood, and increased IGF-I and testosterone concentrations during calfhood and peripubertal period were associated with greater testicular cell proliferation and enhanced function.
Brito
Leonardo F C
LF
Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Dr. Saskatoon, Sask. S7H 4B5, Canada. lfcbrito@lycos.com
Barth
Albert D
AD
Rawlings
Norm C
NC
Wilde
Randal E
RE
Crews
Denny H
DH
Mir
Priya S
PS
Kastelic
John P
JP
D000375:Aging; D000824:Animal Nutritional Physiological Phenomena / Q000502:physiology*; D000818:Animals; D002417:Cattle / Q000097:blood* / Q000254:growth & development; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000097:blood*; D006728:Hormones / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008297:Male; D012741:Sexual Maturation; D013737:Testis / Q000254:growth & development*; D013739:Testosterone / Q000097:blood*; D015430:Weight Gain
D006062:Gonadotropins; D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone