title: C-reactive protein in aortic valve disease.
abstract: Aortic Valve Disease, includes a range of disorder severity from mild leaflet thickening without valve obstruction, "aortic sclerosis", to severe calcified aortic stenosis. It is a slowly progressive active process of valve modification similar atherosclerosis for cardiovascular risk factors, lipoprotein deposition, chronic inflammation, and calcification. Systemic signs of inflammation, as wall and serum CRP, similar to those found in atherosclerosis, are present in patients with degenerative aortic valve stenosis and may be expression of a common disease, useful in monitoring of stenosis progression.
authors.affiliation: Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico Universitario de Valladolid, C/Ramón y Cajal, 47005, Valladolid, Spain. pedrolsanchez@secardiologia.es
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Sanchez
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Mazzone
mesh_terms: D000818:Animals; D001024:Aortic Valve Stenosis / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002986:Clinical Trials as Topic; D006801:Humans; D010818:Practice Patterns, Physicians'; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein