title: The molecular basis of colorectal carcinogenesis.
abstract: The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing the role of four genes, APC, Cox-2, DCC/Smad4, and the mismatch repair genes, in colorectal carcinogenesis.
authors.affiliation: Department of Cell Biology and Medicine, Division of Gastroenterology, Vanderbilt University Medical School, MCN C-2104, 1161 21st Avenue South, Nashville, TN 37232, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Shattuck-Brandt
authors.forename: R N
authors.initials: RN
authors.lastname: DuBois