title: Quantifying the reactivity of a remarkably long-lived difluorinated enol in acidic methanol via solution kinetics and electronic structure calculations.
abstract: A simple enol acetal underwent rapid cleavage in acidic solution to generate a difluorinated enol, which was sufficiently long-lived to be characterized by 2D NMR in a protic solvent at ambient temperature. Density functional theory calculations on a model reaction suggest that there are significant differences in protonation transition state timing between the fluorinated and nonfluorinated enols.
authors.affiliation: Department of Chemistry, University of Leicester, University Road, Leicester LE1 7RH, UK.
authors.forename: Gerry A
authors.initials: GA
authors.lastname: Griffith
authors.forename: Ian H
authors.initials: IH
authors.lastname: Hillier
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Percy
authors.forename: Ricard
authors.initials: R
authors.lastname: Roig
authors.forename: Mark A
authors.initials: MA
authors.lastname: Vincent