title: Functional MRI in the evaluation of oesophageal motility: feasibility, MRI patterns of normality, and preliminary experience in subjects with motility disorders.
abstract: OBJECTIVE
  The aim of this study was to introduce functional magnetic resonance imaging (fMRI) with T1-weighted turbo fast low-angle shot (FLASH) sequences in the evaluation of oesophageal motility and morphology, to formulate MRI patterns of normality in healthy subjects and to demonstrate the feasibility of the method by obtaining a preliminary experience in the study of subjects affected by oesophageal motility disorders.
  
  
  METHODS
  Thirty healthy volunteers and seven patients with radiological and manometric diagnoses of oesophageal motility disorders underwent fMRI with dynamic T1- weighted turbo-FLASH (TFL) sequences during the administration of oral contrast material.
  
  
  RESULTS
  Evaluation of oesophageal function and morphology proved possible in all subjects, as well as the formulation of normality patterns. In patients with motility disorders, fMRI correctly visualised the typical alterations in agreement with radiological and manometric findings.
  
  
  CONCLUSIONS
  Functional MRI sequences acquired during the administration of oral contrast material can evaluate oesophageal transit, providing information on motility and morphology; furthermore, this modality can properly visualise the typical functional and morphological alterations of motility disorders.
authors.affiliation: Dipartimento di Scienze Radiologiche, Università di Roma La Sapienza, Policlincio Umberto I, Viale Regina Elena 324, I-00166 Rome, Italy. valeria.panebianco@uniroma1.it
authors.forename: V
authors.initials: V
authors.lastname: Panebianco
authors.forename: E
authors.initials: E
authors.lastname: Tomei
authors.forename: M
authors.initials: M
authors.lastname: Anzidei
authors.forename: F I
authors.initials: FI
authors.lastname: Habib
authors.forename: C
authors.initials: C
authors.lastname: Catalano
authors.forename: D
authors.initials: D
authors.lastname: Lisi
authors.forename: A
authors.initials: A
authors.lastname: Laghi
authors.forename: R
authors.initials: R
authors.lastname: Passariello
mesh_terms: D000328:Adult; D015154:Esophageal Motility Disorders / Q000473:pathology*; D004947:Esophagus / Q000033:anatomy & histology / Q000473:pathology* / Q000502:physiology; D005260:Female; D005471:Fluoroscopy / Q000379:methods; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged