title: Three-dimensional computational fluid dynamics simulations of particle deposition in the tracheobronchial tree.
abstract: Simulation of the dynamics and disposition of inhaled particles within human lungs is an invaluable tool in both the development of inhaled pharmacologic drugs and the risk assessment of environmental particulate matter (PM). The goal of the present focused study was to assess the utility of three-dimensional computational fluid dynamics (CFD) models in studying the local deposition patterns of PM in respiratory airways. CFD models were validated using data from published experimental studies in human lung casts. The ability of CFD to appropriately simulate trends in deposition patterns due to changing ventilatory conditions was specifically addressed. CFD simulations of airflow and particle motion were performed in a model of the trachea and main bronchi using Fluent Inc.'s FIDAP CFD software. Particle diameters of 8 microm were considered for input flow rates of 15 and 60 L/min. CFD was able to reproduce the observed spatial heterogeneities of deposition within the modeled bifurcations, and correctly predicted the "hot-spots" of particle deposition on carinal ridges. The CFD methods also predicted observed differences in deposition for high-versus-low flow rates. CFD models may provide an efficient means of studying the complex effects of airway geometry, particle characteristics, and ventilatory parameters on particle deposition and therefore aid in the design of human subject experiments.
authors.affiliation: University of North Carolina at Chapel Hill, Department of Environmental Sciences and Engineering, Chapel Hill, North Carolina, USA. kristin_isaacs@yahoo.com
authors.forename: Kristin K
authors.initials: KK
authors.lastname: Isaacs
authors.forename: R B
authors.initials: RB
authors.lastname: Schlesinger
authors.forename: Ted B
authors.initials: TB
authors.lastname: Martonen
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects* / Q000473:pathology*; D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008953:Models, Anatomic; D008962:Models, Theoretical; D010316:Particle Size; D012119:Respiration; D012137:Respiratory System / Q000187:drug effects*; D015657:Respiratory Transport; D012984:Software; D014132:Trachea / Q000187:drug effects* / Q000473:pathology*
chemical_list: D000336:Aerosols