Antisynthetase syndrome associated with sarcoidosis.
A 30-year-old man complained of polyarthralgia and fatigue. The clinical findings and laboratory data included myositis, polyarthritis, interstitial pneumonia, Raynaud's phenomenon, mechanic's hand, and anti PL-7 antibody (threonyl-tRNA synthetase antibody). All of these signs were consistent with antisynthetase syndrome. His chest radiograph revealed bilateral hilar lymphadenopathy. Biopsy specimens from his mediastinal lymph node and muscle showed noncaseating epithelioid cell granulomas. Lung histology revealed nonspecific interstitial pneumonia. Antisynthetase syndrome associated with sarcoidosis was diagnosed. Interstitial pneumonia in this patient responded well to high-dose corticosteroid therapy.
Asanuma
Yu
Y
Clinical Department of Internal Medicine, Jichi Medical School Omiya Medical Center, Saitama.
Koichihara
Reiko
R
Koyama
Shinichiro
S
Kawabata
Yoshinori
Y
Kobayashi
Shio
S
Mimori
Tsuneyo
T
Moriguchi
Masato
M
D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008025:Ligases / Q000276:immunology; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012907:Smoking; D013577:Syndrome
D001323:Autoantibodies; D005938:Glucocorticoids; D011239:Prednisolone; D008025:Ligases