title: The scientific basis of a total asbestos ban.
abstract: Worldwide, in the new millennium, standards for the protection of workers and the general population from as-bestos risks are not equally stringent in all countries. The present review analyzes some arguments which in recent years have been proposed as a rationale for the reconsideration of the scientific background of a total asbestos ban, such as that adopted in the European Union. The conclusion is that in order to ensure adequate protection, there is no alternative to a total ban. The evidence for carcinogenicity of chrysotile is as good as for the amphiboles, the carcinogenic potency of chrysotile is lower than that of the amphiboles, but risk estimates must also be based on extent of exposure (nowadays chrysotile represents 95% of asbestos used worldwide). The fact that induction of mesothelioma by asbestos results from the interaction of environmental exposure and genetic factors reflects a general phenomenon in carcinogenesis and does not warrant any re-consideration of the role of asbestos. The role of SV40 as yet is unclear: even assuming that current risk estimates are correct (which is debatable), this agent would interact with asbestos in only a faction of mesothelioma cases. The effectiveness of protocols suggested for "controlled use" has not been tested with a scientfiic approach: they seem hardly practicable, particularly in the countries which are currently the major consumers of asbestos.
authors.affiliation: University of Turin, Unit of Cancer Epidemiology, Giovanni Scansetti Center for the study of asbestos, Italy. benedetto.terracini@fastwebnet.it
authors.forename: B
authors.initials: B
authors.lastname: Terracini
mesh_terms: D000818:Animals; D001194:Asbestos / Q000009:adverse effects* / Q000145:classification / Q000633:toxicity; D015197:Carcinogenicity Tests; D002274:Carcinogens, Environmental / Q000009:adverse effects / Q000633:toxicity; D003043:Cocarcinogenesis; D015331:Cohort Studies; D006224:Cricetinae; D003906:Developing Countries; D004781:Environmental Exposure; D005062:European Union; D019317:Evidence-Based Medicine; D005260:Female; D020022:Genetic Predisposition to Disease; D014943:Global Health; D015386:Hazardous Substances / Q000009:adverse effects* / Q000633:toxicity; D006801:Humans; D008168:Lung / Q000737:chemistry; D008175:Lung Neoplasms / Q000209:etiology; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000517:prevention & control / Q000821:virology; D051379:Mice; D019016:Mineral Fibers / Q000009:adverse effects; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D016273:Occupational Exposure; D010997:Pleural Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000517:prevention & control / Q000821:virology; D051381:Rats; D012306:Risk; D013539:Simian virus 40 / Q000472:pathogenicity; D013997:Time Factors
chemical_list: D002274:Carcinogens, Environmental; D015386:Hazardous Substances; D019016:Mineral Fibers; D001194:Asbestos