Treatment failure of nosocomial pertussis infection in a very-low-birth-weight neonate.
We describe a case of nosocomial maternal transmission of Bordetella pertussis to a very-low-birth-weight (VLBW) neonate in whom treatment was unsuccessful. This case underscores the need for rapid and sensitive PCR diagnosis in VLBW neonates and in parents with clinical signs of pertussis and suggests that standard treatment may not be appropriate for VLBW neonates.
Bonacorsi
Stéphane
S
Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Paris, France.
Farnoux
Caroline
C
Bidet
Philippe
P
Caro
Valérie
V
Aizenfisz
Sophie
S
Benhayoun
Mounir
M
Aujard
Yannick
Y
Guiso
Nicole
N
Bingen
Edouard
E
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy*; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D015570:Josamycin / Q000627:therapeutic use*; D008297:Male; D017211:Treatment Failure; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014917:Whooping Cough / Q000188:drug therapy* / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017963:Azithromycin; D015570:Josamycin