title: BadM is a transcriptional repressor and one of three regulators that control benzoyl coenzyme A reductase gene expression in Rhodopseudomonas palustris.
abstract: The rate-limiting enzyme of anaerobic benzoate degradation by Rhodopseudomonas palustris, benzoyl coenzyme A (CoA) reductase, is highly sensitive to oxygen, and its synthesis is tightly regulated. We determined that a previously unknown gene in the benzoate gene cluster, badM, encodes a transcriptional repressor of benzoyl-CoA reductase gene expression. BadM controls gene expression from the benzoyl-CoA reductase promoter in concert with two previously described transcriptional activators.
authors.affiliation: Department of Microbiology, Box 357242, 1959 N. E. Pacific Street, University of Washington, Seattle, WA 98195-7242, USA.
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Peres
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Harwood
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism*; D000693:Anaerobiosis; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001565:Benzoates / Q000378:metabolism; D003470:Culture Media; D015964:Gene Expression Regulation, Bacterial; D010088:Oxidoreductases / Q000235:genetics* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D012241:Rhodopseudomonas / Q000201:enzymology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D000214:Acyl Coenzyme A; D001426:Bacterial Proteins; D001565:Benzoates; D003470:Culture Media; D012097:Repressor Proteins; C037817:benzoyl-coenzyme A; D010088:Oxidoreductases