title: An evidence-based, multidisciplinary approach to the clinical considerations, management, and surveillance of adrenal lesions in familial adenomatous polyposis: report of three cases.
abstract: Adrenal masses are commonly discovered incidentally in patients with familial adenomatous polyposis, and adrenal malignancies have been rarely reported. Individuals with familial adenomatous polyposis frequently undergo abdominal CT-scan examinations for surveillance or symptoms. Adrenal lesions often are detected unexpectedly and are thus becoming a common clinical problem in this population. Adrenal lesions encompass a heterogeneous spectrum of pathologic entities, including primary adrenocortical and medullary tumors, benign or malignant lesions, hormonally active or inactive lesions, metastases, and infections. When an adrenal mass is detected, the clinician needs to address two crucial questions: 1) is the mass malignant? and 2) is it hormonally active? This article presents three new cases of incidental adrenal lesions in familial adenomatous polyposis, reviews the medical literature for this setting, and provides an overview of the diagnostic clinical approach and management of the adrenal findings in familial adenomatous polyposis patients.
authors.affiliation: Department of Outreach and Prevention, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
authors.forename: Angel
authors.initials: A
authors.lastname: Ferrández
authors.forename: Lana
authors.initials: L
authors.lastname: Pho
authors.forename: Cindy
authors.initials: C
authors.lastname: Solomon
authors.forename: Wade S
authors.initials: WS
authors.lastname: Samowitz
authors.forename: Scott K
authors.initials: SK
authors.lastname: Kuwada
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Knecht
authors.forename: Maryellyn
authors.initials: M
authors.lastname: Gilfeather
authors.forename: Randal W
authors.initials: RW
authors.lastname: Burt
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D011125:Adenomatous Polyposis Coli / Q000150:complications*; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D000368:Aged; D001416:Back Pain / Q000209:etiology; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008297:Male; D014057:Tomography, X-Ray Computed