title: Effect of Helicobacter pylori eradication therapy in rosacea patients.
abstract: OBJECTIVE
  The causal relation between rosacea and Helicobacter pylori infection is discussed. We evaluated the clinical evolution of rosacea after infection eradication.
  
  
  METHODS
  We have prospectively studied 44 patients diagnosed with rosacea. Helicobacter pylori infection was determined, and infected patients were treated with eradication therapy. The evolution of dermatological symptoms in a subgroup of 29 infected patients in whom eradication had been achieved was followed during 16.8 (+/- 17.8) months. Median age was 50.6 (+/- 14.1) years for 22 women (75.9%) and 7 men (24.1%). Clinical response according to gender and clinical subtype of rosacea was evaluated.
  
  
  RESULTS
  Complete improvement was observed in 10 patients (34.5%; 95% CI: 18.6-54.3%), relevant improvement in 9 (31.1%; 95% CI: 16-51%), poor improvement in 5 (17.2%; 95% CI: 6.5-36.4%), and absence of improvement in 5 cases (17.2%; 95% CI: 6.5-36.4%). No significant differences in dermatological evolution according to sex were observed. Regarding subtype of rosacea there was a relevant improvement in 83.3% (95% CI: 64.1-93.8%) of cases with papulopustular type as opposed to 36.5% (95% CI: 20-56.1%) of cases with erythematous predominance, p = 0.02.
  
  
  CONCLUSIONS
  Based on these results, the relation between Helicobacter pylori and rosacea is supported, and infection should be investigated in these patients because an appreciable percentage of patients diagnosed with rosacea and Helicobacter pylori infection can benefit from eradication therapy, mainly in the papulopustular subtype.
authors.affiliation: Department of Gastroenterology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Boixeda de Miquel
authors.forename: M
authors.initials: M
authors.lastname: Vázquez Romero
authors.forename: E
authors.initials: E
authors.lastname: Vázquez Sequeiros
authors.forename: J R
authors.initials: JR
authors.lastname: Foruny Olcina
authors.forename: P
authors.initials: P
authors.lastname: Boixeda de Miquel
authors.forename: A
authors.initials: A
authors.lastname: López San Román
authors.forename: S
authors.initials: S
authors.lastname: Alemán Villanueva
authors.forename: C
authors.initials: C
authors.lastname: Martín de Argila de Prados
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D012393:Rosacea / Q000150:complications* / Q000382:microbiology