title: [Relations between VDR3 and COL1A1 genes and markers of bone tissue metabolism in patients with chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To study correlation between polymorphism of the genes of vitamin D3 (VDR3), collagen of type 1 alpha-1 (COL1A1) and markers of bone tissue metabolism in chronic obstructive pulmonary disease
  
  
  METHODS
  A total of 56 COPD patients were examined. Bone metabolism was evaluated by osteocalcin (OC) level and betaCL in the blood; BsmI polymorphism of gene VDR3 (genotypes BB, Bb, bb) and Sp1 polymorphism of gene COL1A1 (genotypes SS, Ss, ss)--by polymerase chain reaction. The control group consisted of 50 healthy persons of matched gender and age.
  
  
  RESULTS
  OC and S allele were not the same in genotypes BB, Bb and bb. Ss and ss genotypes carriers had higher beta CL level than SS-carriers. SS and ss genotypes carriers did not differ with betaCL concentrations (p > 0.05).
  
  
  CONCLUSIONS
  Testing of VDR3 and COL1A1 genes gives grounds for detection of predisposition to development of pulmonogenic osteopenic syndrome.
authors.forename: B I
authors.initials: BI
authors.lastname: Gel'tser
authors.forename: E A
authors.initials: EA
authors.lastname: Kochetkova
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Grigor'eva
authors.forename: S A
authors.initials: SA
authors.lastname: Al'bavichus
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Bubnov
mesh_terms: D015415:Biomarkers / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000235:genetics*; D001842:Bone and Bones / Q000378:metabolism*; D016022:Case-Control Studies; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D018167:Receptors, Calcitriol; D015675:Osteocalcin