title: Pemetrexed-induced acute renal failure, nephrogenic diabetes insipidus, and renal tubular acidosis in a patient with non-small cell lung cancer.
abstract: We report a patient with metastatic non-small cell lung cancer who developed renal toxicities manifest as acute renal failure associated with nephrogenic diabetes insipidus and distal renal tubular acidosis following sequential therapy with pemetrexed. The nephrotoxicity occurred concomitantly with severe myelosuppression. We postulate renal tubular toxicity may account for distinct patterns of injury including acute renal failure and tubular cell dysfunction of the distal nephron.
authors.affiliation: Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA.
authors.forename: Vidya
authors.initials: V
authors.lastname: Vootukuru
authors.forename: Yin Ping
authors.initials: YP
authors.lastname: Liew
authors.forename: Joseph V
authors.initials: JV
authors.lastname: Nally
mesh_terms: D000141:Acidosis, Renal Tubular / Q000139:chemically induced* / Q000150:complications; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000150:complications; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000188:drug therapy*; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced* / Q000150:complications; D005260:Female; D005919:Glomerular Filtration Rate; D005971:Glutamates / Q000009:adverse effects*; D006147:Guanine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy*; D008875:Middle Aged; D000068437:Pemetrexed
chemical_list: D000964:Antimetabolites, Antineoplastic; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine