title: New dihydrobenzofuran derivative, awajanoran, from marine-derived Acremonium sp. AWA16-1.
abstract: Awajanoran (1), a new dihydrobenzofuran derivative, was isolated from an agar-culture of Acremonium sp. AWA16-1, which had been isolated from sea mud collected at Awajishima Island in Japan. The structure of 1 was elucidated on the basis of a spectroscopic analysis. This compound inhibited the growth of A549 cells, the human lung adenocarcinoma cell line, with an IC50 value of 17 microg/ml, and also showed antimicrobial activity.
authors.affiliation: Marine Biotechnology Institute Co. Ltd., 3-75-1 Heita, Kamaishi, Iwate 026-0001, Japan. jang.jaehyuk@mbio.jp
authors.forename: Jae-Hyuk
authors.initials: JH
authors.lastname: Jang
authors.forename: Kaneo
authors.initials: K
authors.lastname: Kanoh
authors.forename: Kyoko
authors.initials: K
authors.lastname: Adachi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
mesh_terms: D000164:Acremonium / Q000378:metabolism*; D000230:Adenocarcinoma / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D010636:Phenols; C514532:awajanoran