Association of interleukin-1 receptor antagonist gene polymorphism and susceptibility to human brucellosis.
The aim of this study was to determine the influence of the polymorphism within the intron 2 of the interleukin-1 receptor antagonist gene (IL-1Ra) on the susceptibility to or development of brucellosis. A total of 255 patients with brucellosis and 162 healthy volunteers were genotyped for polymorphisms in intron 2 of the IL-1Ra gene. The frequency of allele 2 of the IL-1Ra gene was significantly higher in patients with brucellosis compared with the controls (24.5% vs 18.5%, P = 0.03). Although the heterozygosity was more prevalent in patients than in control individuals, it did not have any statistical significance (P = 0.1). Alleles 3, 4, and 5 were absent in our study population. This work is the first that verifies a significant association between genetic polymorphism of IL-1Ra and susceptibility to brucellosis.
Hajilooi
M
M
Department of Immunology, Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Rafiei
A
A
Reza Zadeh
M
M
Tajik
N
N
D000328:Adult; D002006:Brucellosis / Q000235:genetics* / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007438:Introns / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D012189:Retrospective Studies
D053590:Interleukin 1 Receptor Antagonist Protein