PGC-1alpha gene and physical activity in type 2 diabetes mellitus.
Exercise stimulates PGC-1alpha gene expression and increases V O2max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1alpha mRNA and nucleotide sequence variation at PGC-1alpha associate with lower level of V O2max and increased diabetes risk. Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.
Franks
Paul W
PW
Genetic Epidemiology and Clinical Research Group, Institute of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden. paul.franks@medicin.umu.se
Loos
Ruth J F
RJ
D001483:Base Sequence; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology*; D005786:Gene Expression Regulation; D014644:Genetic Variation; D005947:Glucose / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D010101:Oxygen Consumption / Q000235:genetics / Q000502:physiology; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D012333:RNA, Messenger / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics*
D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D012333:RNA, Messenger; D014157:Transcription Factors; D005947:Glucose