Dynamic expression of R-spondin family genes in mouse development.
R-spondins (Rspo) are a recently discovered secretory protein family with four members in human and mouse. We and others demonstrated that R-spondins can activate canonical Wnt signaling and beta-catenin-dependent gene expression. Our study further demonstrated that R-spondins are novel ligands for the Frizzled8 and LRP6 (LDL-receptor-related protein 6) receptors. To gain insight into their biological functions, the RNA expression pattern of the mouse R-spondin family genes was analyzed during mouse development. Our study shows that R-spondin gene transcripts are widely expressed with distinct patterns in mouse at different developmental stages.
Nam
Ju-Suk
JS
Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA.
Turcotte
Taryn J
TJ
Yoon
Jeong Kyo
JK
D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics; D005333:Fetus / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008813:Mice, Inbred ICR; D009928:Organ Specificity; D019699:Thrombospondins / Q000235:genetics*; D000098907:R-Spondins
D019699:Thrombospondins; C517523:R-spondin3 protein, mouse; C518903:RSPO1 protein, mouse; C518904:RSPO2 protein, mouse; D000098907:R-Spondins; C518905:RSPO4 protein, mouse