Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: implications for future trials.
Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 x 10(7)pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies.
De Rose
Robert
R
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.
Sullivan
Mark T
MT
Dale
C Jane
CJ
Kelleher
Anthony D
AD
Emery
Sean
S
Cooper
David A
DA
Ramshaw
Ian A
IA
Boyle
David B
DB
Kent
Stephen J
SJ
D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D001830:Body Surface Area; D004306:Dose-Response Relationship, Immunologic; D005587:Fowlpox virus / Q000235:genetics*; D006801:Humans; D008251:Macaca; D019444:Vaccines, DNA / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
D016915:AIDS Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic