title: Adipocyte fatty-acid binding protein is closely associated to the porcine FAT1 locus on chromosome 4.
abstract: We identified 22 polymorphisms in the adipocyte fatty-acid binding protein (FABP4) gene, a strong positional candidate gene for the FAT1 locus in porcine chromosome 4. The most informative polymorphism, an insertion/deletion in intron 1, together with a single nucleotide polymorphism in intron 3, was genotyped in a cross between Iberian and Landrace pigs. After performing QTL, single marker, and haplotype analyses, we showed that there were at least 2 quantitative trait genes in the FAT1 region and that the FABP4 polymorphism was tightly associated to fatness. A comparison of allelic frequencies in a panel of pig breeds suggested that the Del2634C polymorphism was under indirect selection. We also showed that FABP4 is tightly associated to fatness but not growth. Furthermore, a haplotype analysis suggests that there is genetic heterogeneity at the FAT1 locus within the Landrace breed.
authors.affiliation: Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. Anna.mercader@uab.es
authors.forename: A
authors.initials: A
authors.lastname: Mercadé
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Enciso
authors.forename: L
authors.initials: L
authors.lastname: Varona
authors.forename: E
authors.initials: E
authors.lastname: Alves
authors.forename: J L
authors.initials: JL
authors.lastname: Noguera
authors.forename: A
authors.initials: A
authors.lastname: Sánchez
authors.forename: J M
authors.initials: JM
authors.lastname: Folch
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D008297:Male; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D013552:Swine / Q000235:genetics*
chemical_list: D050556:Fatty Acid-Binding Proteins