title: Human artificial chromosomes: potential applications and clinical considerations.
abstract: Human artificial chromosomes demonstrate promise as a novel class of nonintegrative gene therapy vectors. The authors outline current developments in human artificial chromosome technology and examine their potential for clinical application.
authors.affiliation: Institute for Genome Sciences & Policy, Duke University, 101 Science Drive, Durham, NC 27708, USA. basu0005@mc.duke.edu
authors.forename: Joydeep
authors.initials: J
authors.lastname: Basu
authors.forename: Huntington F
authors.initials: HF
authors.lastname: Willard
mesh_terms: D022222:Chromosomes, Artificial, Human; D015870:Gene Expression; D018014:Gene Transfer Techniques; D005818:Genetic Engineering; D005819:Genetic Markers; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans
chemical_list: D005819:Genetic Markers