title: Anthelmintic action of eprinomectin in lactating Anglo-Nubian goats in Brazil.
abstract: Eprinomectin is the only avermectin approved for use to control gastrointestinal nematodes in lactating cows. Some studies in the USA and Europe have also demonstrated that this drug is highly effective in small ruminants. The aim of the present work was to evaluate the anthelmintic efficacy of pour-on eprinomectin in Anglo-Nubian goats at the end of lactation. Twenty-four goats were used, naturally infected with gastrointestinal nematodes, and divided into two groups: control and treated with eprinomectin (Eprinex, Merial, pour-on 0.5%) at a dose of 850 microg/kg. Counts were made of the eggs per gram (EPG) of feces, along with coprocultures, on days -7, 0, 4, 8, 11, 15, 18, 22, 25 and 29. The milk production of each group was recorded throughout the experiment. The coprocultures detected 98% Haemonchus contortus and 2% Oesophagostomum. There was no statistically significant difference (P > 0.05) in daily milk output between the two groups. Eprinomectin at the tested dosage was not effective (P > 0.05) in reducing the EPG. Positive results would serve as basis for use of an avermectin without residues in dairy goats, providing a scientific basis for greater food safety.
authors.affiliation: Embrapa Pecuária Sudeste, Rodovia Washington Luiz, Km 234-Caixa Postal 339, 13560-970, São Carlos, SP, Brazil. carolina@cppse.embrapa.br
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: de Souza Chagas
authors.forename: Luiz
authors.initials: L
authors.lastname: da Silva Vieira
authors.forename: Wladimir
authors.initials: W
authors.lastname: Rodrigues Aragão
authors.forename: Andrine Maria
authors.initials: AM
authors.lastname: do Carmo Navarro
authors.forename: Luciana Cristine
authors.initials: LC
authors.lastname: Vasques Villela
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy*; D006041:Goats / Q000502:physiology*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007774:Lactation / Q000502:physiology*; D008892:Milk; D010270:Parasite Egg Count
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; C101434:eprinomectin