Diffusion of nutrients molecules and model drug carriers through mucin layer investigated by magnetic resonance imaging with chemical shift resolution.
Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.e., a solution of ethanol and glucose) and of a model drug carrier (i.e., an equimolar solution of cationic and nonionic surfactants) through a mucin gel have been investigated. This study shows that transport properties of the diffusing molecules through a mucin gel are dependent on their size and physicochemical properties. In addition, we show that mucin gel acts as an efficient selective barrier. It favors the disintegration of mixed micelles of nonionic and cationic surfactants by stopping the diffusion of cationic surfactants with slightly affecting the diffusion of the nonionic surfactants.
Lafitte
Géraldine
G
Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden. geraldine.lafitte@fkem1.lu.se
Thuresson
Krister
K
Söderman
Olle
O
D017666:Deuterium Oxide / Q000737:chemistry; D004058:Diffusion; D004337:Drug Carriers; D000431:Ethanol / Q000737:chemistry; D005079:Excipients; D005502:Food; D005752:Gastric Mucins / Q000737:chemistry*; D005782:Gels; D005947:Glucose / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D011136:Polysorbates / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D050337:Trimethyl Ammonium Compounds / Q000737:chemistry
D004337:Drug Carriers; D005079:Excipients; D005752:Gastric Mucins; D005782:Gels; D011136:Polysorbates; D013501:Surface-Active Agents; D050337:Trimethyl Ammonium Compounds; D000431:Ethanol; D005947:Glucose; D017666:Deuterium Oxide; C009410:tetradecyltrimethylammonium