title: Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining.
abstract: Motivated by the observation that the Aspergillus nidulans genome bears multiple anthranilic acid synthase gene copies, the fungal metabolome was reinvestigated under various fermentation conditions, resulting in the discovery of novel prenylated quinolin-2-one alkaloids, two of which bear unprecedented terpenoid side chains.
authors.affiliation: Leibniz-Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11 a, D-07745, Jena, Germany.
authors.forename: Kirstin
authors.initials: K
authors.lastname: Scherlach
authors.forename: Christian
authors.initials: C
authors.lastname: Hertweck
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis* / Q000737:chemistry; D001233:Aspergillus nidulans / Q000378:metabolism*; D016681:Genome, Fungal / Q000235:genetics*; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D011804:Quinolines; D015363:Quinolones; C522533:aspoquinolone A; C037219:quinoline