title: The contribution of occupational risks to the global burden of disease: summary and next steps.
abstract: BACKGROUND
  The Comparative Risk Assessment (CRA) project of the World Health Organization (WHO) assessed worldwide mortality and morbidity in the year 2000 resulting from exposures to selected occupational hazards. This article summarizes findings of the WHO CRA project, presents the estimates of the International Labor Organization (ILO) for total deaths due to workplace risks, and calls for action.
  
  
  OBJECTIVE
  Global burden estimates and counts of deaths assist ministers and other decision and policy makers to make informed decisions and to take action regarding risk reduction.
  
  
  METHODS
  The WHO CRA methodology combined the proportions of the population exposed to five occupational hazards (excluding numerous risks due to inadequate global data) with relative risk measures to estimate attributable fractions of the selected health outcomes for both morbidity and mortality. ILO estimates of total numbers of global work-related injury deaths apply national fatality rates to employment data for the particular country; for disease deaths ILO uses an attributable risk approach.
  
  
  RESULTS
  In 2000, the selected occupational risk factors were responsible worldwide for 37% of back pain, 16% of hearing loss, 13% of chronic obstructive pulmonary disease (COPD), 11% of asthma, 8% of injuries, 9% of lung cancer and 2% of leukemia, and about 100% of pneumoconioses and mesothelioma. These selected risks at work resulted in the loss of about 24 million years of healthy life and caused 850,000 deaths worldwide, about 40% of the ILO estimate of 2.2 million total deaths.
  
  
  CONCLUSIONS
  These global and regional analyses have identified areas where specific preventive actions are required.
authors.affiliation: National Institute for Occupational Safety and Health, Room 715H, Humphrey Building, 200 Independence Avenue SW, Washington, DC 20201, USA. mfingerhut@cdc.gov
authors.forename: Marilyn
authors.initials: M
authors.lastname: Fingerhut
authors.forename: Deborah Imel
authors.initials: DI
authors.lastname: Nelson
authors.forename: T
authors.initials: T
authors.lastname: Driscoll
authors.forename: Marisol
authors.initials: M
authors.lastname: Concha-Barrientos
authors.forename: Kyle
authors.initials: K
authors.lastname: Steenland
authors.forename: Laura
authors.initials: L
authors.lastname: Punnett
authors.forename: Annette
authors.initials: A
authors.lastname: Prüss-Ustün
authors.forename: J
authors.initials: J
authors.lastname: Leigh
authors.forename: C
authors.initials: C
authors.lastname: Corvalan
authors.forename: G
authors.initials: G
authors.lastname: Eijkemans
authors.forename: J
authors.initials: J
authors.lastname: Takala
mesh_terms: D000062:Accidents, Occupational / Q000401:mortality; D001249:Asthma / Q000453:epidemiology / Q000209:etiology; D001416:Back Pain / Q000453:epidemiology / Q000209:etiology; D002908:Chronic Disease; D003625:Data Collection; D014943:Global Health; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission; D034381:Hearing Loss / Q000453:epidemiology / Q000209:etiology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology / Q000635:transmission; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000706:statistics & numerical data; D008017:Life Expectancy; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology; D009784:Occupational Diseases / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D016272:Occupational Health; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000209:etiology; D012306:Risk; D018570:Risk Assessment; D012307:Risk Factors; D014944:World Health Organization; D014947:Wounds and Injuries / Q000453:epidemiology / Q000209:etiology