title: The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis.
abstract: OBJECTIVE
  To investigate the association of polymorphisms of CDT1 and GMNN gene, two important genes participating in DNA replication, with the risk of sporadic breast cancer.
  
  
  METHODS
  Using polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP) and the primer-introduced restriction analysis (PIRA)-PCR assay to genotype the CDT1 838G/A and GMNN 387C/A polymorphisms in a case-control study of 427 breast cancer cases and 477 cancer-free controls in a Chinese population.
  
  
  RESULTS
  No significant association of the CDT1 838G/A and GMNN 387C/A polymorphisms with the risk of breast cancer was found (adjusted OR:1.16, 95% CI:0.88-1.54 for CDT1 GA+AA genotypes and adjusted OR:0.90, 95% CI:0.67-1.21 for GMNN CA+AA genotypes). However, in the stratified analyses, a significant association of CDT1 GA+AA genotypes with breast cancer risk among subjects with family history of cancer was found (adjusted OR:2.21, 95% CI:1.20-4.09).
  
  
  CONCLUSIONS
  These findings suggest that the CDT1 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of breast cancer, but CDT1 variant may have a potential role only in genetically susceptible women.
authors.affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, Jiangsu, 210029 PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhi-bin
authors.initials: ZB
authors.lastname: Hu
authors.forename: Xiang-jun
authors.initials: XJ
authors.lastname: Zhai
authors.forename: Xue-chen
authors.initials: XC
authors.lastname: Wang
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Qin
authors.forename: Wen-sen
authors.initials: WS
authors.lastname: Chen
authors.forename: Guang-fu
authors.initials: GF
authors.lastname: Jin
authors.forename: Ji-yong
authors.initials: JY
authors.lastname: Liu
authors.forename: Xin-ru
authors.initials: XR
authors.lastname: Wang
authors.forename: Yong-fei
authors.initials: YF
authors.lastname: Tan
authors.forename: Qing-yi
authors.initials: QY
authors.lastname: Wei
authors.forename: Hong-bing
authors.initials: HB
authors.lastname: Shen
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D002681:China; D005260:Female; D064248:Geminin; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: C467199:CDT1 protein, human; D018797:Cell Cycle Proteins; C577995:GMNN protein, human; D064248:Geminin