[The expression of transforming growth factor beta1, interleukin-6, 11 and 17 in nasal mucosa of allergic rhinitis patients].
OBJECTIVE
To explore the protein expression of transforming growth factor (TGF)-beta1, interleukin (IL)-6, 11, and 17 in the nasal mucosa of allergic rhinitis patients.


METHODS
The protein expression of TGF-beta1, IL-6, 11, and 17 in the inferior turbinate tissues from 19 allergic rhinitis patients and from 21 non-allergic patients underwent nasal septum operation was detected by enzyme-linked immunosorbent assay.


RESULTS
(1) Compared with tissues from non-allergic patients, the expression of TGF-beta1 protein was significant increased in the tissues from allergic rhinitis patients (P < 0.01); (2) As to the protein expression of IL-6, 11 and 17, there was no significant difference between allergic rhinitis patients and non-allergic patients (P > 0.05); (3) The expression of TGF-beta1, IL-6, 11, and 17 was similar between the allergic rhinitis patients with and without asthma (P > 0.05).


CONCLUSIONS
TGF-beta1 , while not IL-6, 11 and 17, may play a role in the tissue remodeling processes in allergic rhinitis. This expression profile may contribute to the difference in the tissue remodeling between allergic rhinitis and asthma.
Liu
Zheng
Z
Department of Otolaryngology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China. zhengliuent@hotmail.com
Lu
Xiang
X
Wang
Heng
H
Peng
Liyan
L
You
Xuejun
X
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000378:metabolism*; D005260:Female; D006801:Humans; D017370:Interleukin-11 / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D055815:Young Adult
C508611:IL11 protein, human; C508600:IL6 protein, human; D017370:Interleukin-11; D020381:Interleukin-17; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1