Thrombotic thrombocytopenic purpura masquerading as hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome in late pregnancy.
BACKGROUND
Thrombotic thrombocytopenic purpura rarely presents during late pregnancy or immediately postpartum. This report describes the clinical course of a patient considered to have hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome but later determined to have thrombotic thrombocytopenic purpura.


METHODS
At 37 weeks of gestation, a multiparous woman was diagnosed with HELLP syndrome. She received high-dose dexamethasone, magnesium, antihypertensives, and platelets before delivery. Over the next 36 hours, renal function acutely worsened and death ensued. One week after death a plasma ADAMTS13 activity of 4% was reported.


CONCLUSIONS
Thrombotic thrombocytopenic purpura can mimic HELLP syndrome late in gestation. Lack of response to dexamethasone within 12-24 hours and atypical relationships among laboratory values are two clues that thrombotic thrombocytopenic purpura may be the underlying pathology and that plasma exchange is emergently needed.
Rehberg
Jonathan F
JF
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
Briery
Christian M
CM
Hudson
William T
WT
Bofill
James A
JA
Martin
James N
JN
D051722:ADAM Proteins / Q000097:blood; D000071120:ADAMTS13 Protein; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage; D017604:Cesarean Section, Repeat; D003907:Dexamethasone / Q000008:administration & dosage; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D005865:Gestational Age; D017359:HELLP Syndrome; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage; D017713:Platelet Transfusion; D011247:Pregnancy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis*; D051437:Renal Insufficiency
D000959:Antihypertensive Agents; D003907:Dexamethasone; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human; D008274:Magnesium