title: Course of functional status and pain in osteoarthritis of the hip or knee: a systematic review of the literature.
abstract: OBJECTIVE
  To systematically review studies describing the course of functioning in patients with osteoarthritis (OA) of the hip or knee and identifying potential prognostic factors.
  
  
  METHODS
  A systematic search was performed. Studies involving patients with hip or knee OA, >6 months of followup, and outcome measures on functional status or pain were included. Methodologic quality was assessed using a standardized set of 11 criteria; a qualitative data analysis was performed.
  
  
  RESULTS
  Approximately 6,500 titles and abstracts were screened and 48 publications were considered for inclusion. Eighteen studies, 4 of which met the high methodologic quality criteria, were included. For hip OA, there was limited evidence that functional status and pain do not change during the first 3 years of followup. After 3 years, however, a worsening of functional status and pain was seen. For knee OA, there was conflicting evidence for the first 3 years and limited evidence for worsening of pain and functional status after 3 years. Furthermore, limited evidence was established for negative associations between future functional status and laxity, proprioceptive inaccuracy, age, body mass index, and knee pain intensity. In contrast, greater muscle strength, better mental health, better self-efficacy, social support, and more aerobic exercise were protective factors in the first 3 years.
  
  
  CONCLUSIONS
  Pain and functional status in hip or knee OA seem to deteriorate slowly, with limited evidence for worsening after 3 years of followup. In specific subgroups, prognosis in the first 3 years of followup was either worse or better, as both risk factors and protective factors were identified. Prognostic factors included biomechanical factors, psychological factors, clinical factors, and treatment modalities. To strengthen the evidence, further high-quality longitudinal research on hip or knee OA functioning is needed.
authors.affiliation: Netherlands Institute for Health Services Research, Utrecht, The Netherlands. g.vandijk@nivel.nl
authors.forename: Gabriella M
authors.initials: GM
authors.lastname: van Dijk
authors.forename: Joost
authors.initials: J
authors.lastname: Dekker
authors.forename: Cindy
authors.initials: C
authors.lastname: Veenhof
authors.forename: Cornelia H M
authors.initials: CH
authors.lastname: van den Ende
mesh_terms: D018450:Disease Progression; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D015207:Osteoarthritis, Hip / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D020370:Osteoarthritis, Knee / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D010146:Pain / Q000209:etiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity