title: Endovascular treatment strategies for cerebral vasospasm.
abstract: Cerebral vasospasm is a significant cause of morbidity and mortality in patients who have sustained a subarachnoid hemorrhage from aneurysm rupture. Symptomatic cerebral vasospasm is also a strong predictor of poor clinical outcome and has thus drawn a great deal of interest from cerebrovascular surgeons. Although medical management is the cornerstone of treatment for this condition, endovascular intervention may be warranted for those in whom this treatment fails and in whom symptomatic vasospasm subsequently develops. The rapid advancements in endovascular techniques and pharmacological agents used to combat this pathological state continue to offer promise in broadening the available treatment armamentarium. In this article the authors discuss the rationale and basis for using the various endovascular options for the treatment of cerebral vasospasm, and they also discuss the limitations, complications, and efficacy of these treatment strategies in regard to neurological condition and outcome.
authors.affiliation: Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Mindea
authors.forename: Benson P
authors.initials: BP
authors.lastname: Yang
authors.forename: Bernard R
authors.initials: BR
authors.lastname: Bendok
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Miller
authors.forename: H Hunt
authors.initials: HH
authors.lastname: Batjer
mesh_terms: D017542:Aneurysm, Ruptured / Q000150:complications; D000800:Angioplasty, Balloon / Q000379:methods*; D006801:Humans; D010208:Papaverine / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000150:complications; D013997:Time Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000628:therapy*
chemical_list: D014665:Vasodilator Agents; D010208:Papaverine