title: Coexistence of tonic firing and bursting in cortical neurons.
abstract: Sustained neuronal activity can be broadly classified as either tonic firing or bursting. These two major patterns of neuronal oscillations are state dependent and may coexist. The dynamics and intracellular mechanisms of transitions between tonic firing and bursting in cortical networks remain poorly understood. Here we describe a detailed two-compartment conductance-based cortical neuron model which exhibits bistability with hysteresis between tonic firing and bursting for elevated extracellular potassium concentration. The study explains the ionic and dynamical mechanisms of burst generation and reveals the conditions underlying coexistence of two different oscillatory modes as a function of neuronal excitability.
authors.affiliation: Salk Institute, 10010 North Torrey Pines Rd., La Jolla, California 92037, USA.
authors.forename: Flavio
authors.initials: F
authors.lastname: Fröhlich
authors.forename: Maxim
authors.initials: M
authors.lastname: Bazhenov
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D011188:Potassium / Q000502:physiology*
chemical_list: D011188:Potassium