Conformational analogues of Oxamflatin as histone deacetylase inhibitors.
Conformational analogues of the hydroxamic acid Oxamflatin compounds, have been synthesised to enable evaluation of the impact of varying the linking section on histone deacetylase inhibition. Preliminary testing indicates treatment of leukaemia cells with each of the analogues leads to significant inhibition of histone deacetylase and reduction in cell growth and proliferation.
Dear
Anthony E
AE
Australian Centre for Blood Diseases, Department of Medicine, Monash University, 6th floor Barnet Tower, 89 Commercial Rd, Prahran 3181, Australia.
Liu
Hong B
HB
Mayes
Penelope A
PA
Perlmutter
Patrick
P
D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D018922:HL-60 Cells; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry* / Q000494:pharmacology*; D008968:Molecular Conformation
D001713:Biphenyl Compounds; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; C100692:oxamflatin