title: Synthesis and antibacterial activity of nitroaryl thiadiazole-levofloxacin hybrids.
abstract: Novel levofloxacin-containing hybrids carrying a 5-(nitroaryl)-1,3,4-thiadiazol-2-yl group were synthesized and evaluated in vitro against Gram-positive and Gram-negative bacteria. Preliminary data indicated that levofloxacin-nitrofuran and levofloxacin-nitroimidazole hybrids have a potent activity against Gram-positive organisms with enhanced anti-staphylococcal activity compared with the parent quinolone (N-desmethyl levofloxacin).
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran. aforoumadi@yahoo.com
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Shahla
authors.initials: S
authors.lastname: Mansouri
authors.forename: Saeed
authors.initials: S
authors.lastname: Emami
authors.forename: Javad
authors.initials: J
authors.lastname: Mirzaei
authors.forename: Maedeh
authors.initials: M
authors.lastname: Sorkhi
authors.forename: Nosratollah
authors.initials: N
authors.lastname: Saeid-Adeli
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013830:Thiadiazoles; D064704:Levofloxacin; D015242:Ofloxacin