title: Saccular aneurysms on straight and curved vessels are subject to different hemodynamics: implications of intravascular stenting.
abstract: Our aim was to examine hemodynamic implications of intravascular stenting in the canine venous pouch (sidewall or straight-vessel) and rabbit elastase (curved-vessel) aneurysm models. Flow dynamics in stented (Wallstent) and nonstented versions were studied by using computational fluid dynamics simulations and in vitro flow visualization, with a focus on stent placement effects on aneurysmal flow stagnancy and flow impingement. Results show that sidewall and curved aneurysm models have fundamentally different hemodynamics (shear-driven versus inertia-driven) and thus stent placement outcomes.
authors.affiliation: Toshiba Stroke Research Center, Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, NY 14214, USA. huimeng@buffalo.edu
authors.forename: H
authors.initials: H
authors.lastname: Meng
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Kim
authors.forename: R D
authors.initials: RD
authors.lastname: Ecker
authors.forename: L N
authors.initials: LN
authors.lastname: Hopkins
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D004195:Disease Models, Animal; D004285:Dogs; D004395:Dye Dilution Technique; D004867:Equipment Design; D066298:In Vitro Techniques; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000628:therapy*; D008955:Models, Cardiovascular; D011817:Rabbits; D012008:Recurrence; D015607:Stents