A structural-energetic basis for B-cell epitope prediction.
Structural-energetic analysis of peptide and protein antigens in the context of binding to antibody reveals fundamental differences between the cross-reactions of antipeptide antibody with protein and antiprotein antibody with peptide, providing a physicochemical basis for B-cell epitope prediction as applied to the development of peptide-based vaccines and immunodiagnostics.
Caoili
Salvador Eugenio C
SE
Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, 547 Pedro Gil Street, Ermita, Manila 1000, Philippines. badong@cm.upm.edu.ph
D000465:Algorithms; D000818:Animals; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D013816:Thermodynamics
D018985:Epitopes, B-Lymphocyte