title: Montmorillonite ameliorates hyperthyroidism of rats and mice attributed to its adsorptive effect.
abstract: The present study aims to evaluate the adsorbing effect of montmorillonite on thyroid hormone in the entero-hepatic circulation. The concentration of thyroid hormone in the serum of hyperthyroidism model rats and in solution was measured by radioimmunoassay and ultraviolet spectrometry, respectively. The body weight, temperature, and consumption of food and water were observed in hyperthyroidism model rats. Furthermore, hypoxia tolerance, sodium-pentobarbital-induced sleep time, spontaneous activities were measured on hyperthyroidism model mice after being treated with montmorillonite. Results showed that montmorillonite adsorbed thyroxin (T(4)) and triiodothyronine (T(3)) in vitro. Montmorillonite at dosage of 1.0 g/kg and 0.3 g/kg decreased thyroid hormone levels on hyperthyroidism model rats; Montmorillonite (2.0 g/kg and 0.6 g/kg) prolonged the sleep time, improved the hypoxia tolerant capacity and reduced the spontaneous activities of the hyperthyroidism model mice. These results suggest montmorillonite has anti-hyperthyroidism effect attributed to its adsorptive effect.
authors.affiliation: Department of Pharmacology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cai
authors.forename: Xin-fang
authors.initials: XF
authors.lastname: Meng
authors.forename: Yong-xiao
authors.initials: YX
authors.lastname: Cao
authors.forename: Hua
authors.initials: H
authors.lastname: Lu
authors.forename: Shao-fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Liang-zhen
authors.initials: LZ
authors.lastname: Zhou
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000818:Animals; D013956:Antithyroid Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D001546:Bentonite / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006980:Hyperthyroidism / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects; D013974:Thyroxine / Q000097:blood / Q000737:chemistry; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood / Q000737:chemistry
chemical_list: D013956:Antithyroid Agents; D014284:Triiodothyronine; D001546:Bentonite; D013974:Thyroxine