[The side effects of antiretroviral therapy].
The introduction of highly active antiretroviral therapy (HAART) has resulted in tremendous improvements in morbidity and mortality in HIV-infected patients. However, the use of these drugs has coincided with an increasing number of reports of gastrointestinal, hepatic or metabolic side effects. Soon after beginning antiretroviral treatment drug rashes, hypersensitivity reactions, immune reconstitution syndrome or injection site reaction are frequently seen. Under HAART dyslipidemia, impaired glucose metabolism and elevated liver function are observed. In the later treatment phase, lipodystrophy, a combination of peripheral lipoatrophy and central fat accumulation, occurs.
Hartmann
M
M
Universitätshautklinik, Heidelberg, Germany. Martin.Hartmann@med.uni-heidelberg.de
D019380:Anti-HIV Agents / Q000009:adverse effects; D044966:Anti-Retroviral Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D003875:Drug Eruptions / Q000209:etiology*; D050171:Dyslipidemias / Q000139:chemically induced; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D005947:Glucose / Q000378:metabolism; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007333:Insulin Resistance; D007674:Kidney Diseases / Q000139:chemically induced; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000188:drug therapy; D009422:Nervous System Diseases / Q000139:chemically induced; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects
D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents; D000960:Hypolipidemic Agents; D018894:Reverse Transcriptase Inhibitors; D005947:Glucose