title: [Delta5-7-Ketosterols with modified side chain: the synthesis and the effects on viability and cholesterol biosynthesis in Hep G2 cells].
abstract: (22E)-3beta-Hydroxysitosta-5,22-dien-7-one, (22R, 23R)-3beta,22,23-trihydroxysitost-5-en-7-one, and (22R, 23R)-3beta-hydroxy-22,23-isopropylidenedioxysitost-5-en-7-one were synthesized. The cytotoxicity and effects on cholesterol biosynthesis of the resulting 7-ketosterols, 7-ketocholesterol, and (22S,23S)-3beta-hydroxy-22,23-oxidositost-5-en-7-one were studied in hepatoblastoma Hep G2 cells.
authors.forename: E A
authors.initials: EA
authors.lastname: Piĭr
authors.forename: G E
authors.initials: GE
authors.lastname: Morozevich
authors.forename: F V
authors.initials: FV
authors.lastname: Drozdov
authors.forename: V P
authors.initials: VP
authors.lastname: Timofeev
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Misharin
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002784:Cholesterol / Q000096:biosynthesis*; D006801:Humans; D007664:Ketosteroids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D007664:Ketosteroids; D002784:Cholesterol