Different effects of difructose anhydride III and inulin-type fructans on caecal microbiota in rats.
The effects of different kinds of inulin-type fructans on caecal microbiota were evaluated in rats. Four groups of male Wistar rats were fed either a control diet, or diets containing 5% inulin, 5% fructooligosaccharides (FOS), or 5% difructose anhydride III (DFAIII) for two weeks. In the DFAIII group, caecal propionate, butyrate, counts of bifidobacteria, and total anaerobes were lower than in the inulin group, while caecal propionate, succinate, counts of bifidobacteria, and total anaerobes were lower than in the FOS group. Compared to controls, in the DFAIII group the counts of clostridia in caecum were increased by 3 log units. However, this change was statistically not significant. There were no differences between inulin and FOS groups for the pool of short chain fatty acids in caecum and bacterial counts. Results indicate that DFAIII has different effects on caecal microbiota compared to inulin and FOS and that these differences are most likely due to the alpha(3-->2) bonds in DFAIII.
Tamura
Akiko
A
Research Institute, FANCL Co, Yokohama, Japan. aktamura@fancl.co.jp
Mita
Yuki
Y
Shigematsu
Norihiro
N
Hara
Hiroshi
H
Nishimura
Naomichi
N
D000818:Animals; D001420:Bacteria, Aerobic / Q000187:drug effects / Q000254:growth & development; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000254:growth & development*; D002432:Cecum / Q000737:chemistry / Q000382:microbiology*; D015169:Colony Count, Microbial / Q000662:veterinary; D004187:Disaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D002149:Energy Intake / Q000187:drug effects; D005232:Fatty Acids, Volatile / Q000032:analysis; D007444:Inulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009844:Oligosaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
D004187:Disaccharides; D005232:Fatty Acids, Volatile; D009844:Oligosaccharides; C116580:fructooligosaccharide; C087758:difructose anhydride III; D007444:Inulin