title: Coarse-grained lattice model for molecular recognition.
abstract: We present a simple model which allows us to investigate the equilibrium aspects of molecular recognition between rigid biomolecules on a generic level. Using a two-stage approach, which consists of a design and a testing step, the role of cooperativity and of varying bond strength in molecular recognition is investigated. Cooperativity is found to enhance selectivity. In complexes which require a high binding flexibility, a small number of strong bonds seems to be favored compared to a situation with many but weak bonds.
authors.affiliation: Fakultät für Physik, Universität Bielefeld, D-33615 Bielefeld, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Behringer
authors.forename: Andreas
authors.initials: A
authors.lastname: Degenhard
authors.forename: Friederike
authors.initials: F
authors.lastname: Schmid
mesh_terms: D001703:Biophysics / Q000379:methods*; D008954:Models, Biological; D008958:Models, Molecular; D015233:Models, Statistical; D008962:Models, Theoretical; D011336:Probability; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D011506:Proteins