Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments.
We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory impairment (increased aversive arm time) but only 0.5 mg/kg reserpine decreased locomotion (entries in enclosed arms). The results suggest that the DAVT evaluation in reserpine-treated mice can be a useful model for studying cognitive deficits accompanied by motor impairments.
Carvalho
Rita C
RC
Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, Brazil.
Patti
Camilla C
CC
Takatsu-Coleman
André L
AL
Kameda
Sonia R
SR
Souza
Claudio F
CF
Garcez-do-Carmo
Lucia
L
Abílio
Vanessa C
VC
Frussa-Filho
Roberto
R
Silva
Regina H
RH
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000150:complications*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000150:complications*; D012110:Reserpine / Q000494:pharmacology*
D018759:Adrenergic Uptake Inhibitors; D012110:Reserpine