Glycan microarray technologies: tools to survey host specificity of influenza viruses.
New technologies are urgently required for rapid surveillance of the current H5N1 avian influenza A outbreaks to gauge the potential for adaptation of the virus to the human population, a crucial step in the emergence of pandemic influenza virus strains. Owing to the species-specific nature of the interaction between the virus and host glycans, attention has recently focused on novel glycan array technologies that can rapidly assess virus receptor specificity and the potential emergence of human-adapted H5N1 viruses.
Stevens
James
J
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. jstevens@scripps.edu
Blixt
Ola
O
Paulson
James C
JC
Wilson
Ian A
IA
D000818:Animals; D001717:Birds; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004196:Disease Outbreaks / Q000662:veterinary; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000378:metabolism*; D005585:Influenza in Birds / Q000821:virology; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods* / Q000662:veterinary; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D011991:Receptors, Virus / Q000737:chemistry* / Q000378:metabolism*; D013045:Species Specificity
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D011134:Polysaccharides; D011991:Receptors, Virus