Absent/reduced glucose transporter-1 protein expression in infantile subglottic haemangiomas.
BACKGROUND
Positive immunohistochemical staining for glucose transporter-1 protein (GLUT1) is a characteristic of cutaneous infantile haemangiomas.


OBJECTIVE
To examine GLUT1 expression in subglottic haemangiomas.


METHODS
Review of clinical notes and biopsy tissue with immunostaining for GLUT1 in 14 patients with subglottic haemangiomas.


RESULTS
GLUT1 immunostaining was negative in 11 cases, and focally positive in three. No subglottic haemangiomas demonstrated the intense diffuse positive GLUT1 staining seen in cutaneous infantile haemangiomas. Five patients had cutaneous as well as subglottic haemangiomas, one of whom had a GLUT1-negative subglottic haemangioma and a GLUT1-positive cutaneous haemangioma of the lip.


CONCLUSIONS
Subglottic haemangiomas appear immunohistochemically different from cutaneous infantile haemangiomas, which may reflect differences in endothelial cell differentiation or underlying aetiology.
Purvis
D J
DJ
Department of Dermatology, Great Ormond Street Hospital for Children, London, UK.
Harper
J I
JI
Hartley
B E
BE
Sebire
N J
NJ
D005931:Glottis; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006391:Hemangioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
D051272:Glucose Transporter Type 1; D009363:Neoplasm Proteins