title: Safety of epirubicin adjuvant chemotherapy in a breast cancer patient with chronic renal failure undergoing hemodialytic treatment.
abstract: Anthracycline-based adjuvant chemotherapy is very effective in early breast cancer, but there are limited data on the use of epirubicin in patients with chronic renal failure undergoing hemodialytic treatment. We report the case of a patient with early breast cancer and chronic renal failure who was treated with adjuvant weekly epirubicin. Treatment was well tolerated. The patient is still alive and relapse free 58 months after surgery. If the patient will be disease free after 5 years, she will be reconsidered for renal transplantation. In conclusion, weekly epirubicin appears to be a safe adjuvant chemotherapy option for early breast cancer patients with chronic renal failure undergoing hemodialytic treatment.
authors.affiliation: Medical Oncology, Perugia Hospital, Italy. stefania.gori@tin.it
authors.forename: Stefania
authors.initials: S
authors.lastname: Gori
authors.forename: Antonio
authors.initials: A
authors.lastname: Rulli
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Mosconi
authors.forename: Angelo
authors.initials: A
authors.lastname: Sidoni
authors.forename: Mariantonietta
authors.initials: M
authors.lastname: Colozza
authors.forename: Lucio
authors.initials: L
authors.lastname: Crinò
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D000903:Antibiotics, Antineoplastic; D015251:Epirubicin