title: Comparison of intramuscular and intradermal applications of hepatitis B vaccine in hemodialysis patients.
abstract: This study compared the application of intramuscular recombinant hepatitis B vaccine in hemodialysis patients with the application of accelerated intradermal recombinant hepatitis B vaccine, which can be applied with one-tenth of the standard dose. Sixty seronegative patients for hepatitis B were randomly separated into two groups. Twenty mug of the recombinant hepatitis B vaccine was intramuscularly applied at 0-, 1-, 2-, and 6-month intervals to the first group (32 cases). One more dose was applied at month 12 to those whose anti-HBs titers remained below 100 mIU/mL at month 7. The same vaccine was intradermally applied at 2 microg dose six times with one-month intervals to the second group (28 cases). Vaccine applications were continued in those whose anti-HBs titers remained below 100 mIU/mL at month 7 until antibody titers reached above this value or until the dose number became 12. Measurements of antibody titers were repeated at month 13 in both groups. As a result, in the vaccination of hemodialysis patients against hepatitis B, the accelerated ID application of hepatitis B vaccine with a dose reduced to one-tenth is more cost-effective than the standard dose vaccination schedules. Especially for hemodialysis patients, the time has come for routine application of ID hepatitis B vaccine as an alternative vaccination method.
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: M Kasim
authors.initials: MK
authors.lastname: Karahocagil
authors.forename: Turan
authors.initials: T
authors.lastname: Buzgan
authors.forename: Hasan
authors.initials: H
authors.lastname: Irmak
authors.forename: Hasan
authors.initials: H
authors.lastname: Karsen
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Akdeniz
authors.forename: Nevzat
authors.initials: N
authors.lastname: Akman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000917:Antibody Formation; D005260:Female; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017325:Hepatitis B Vaccines