A hundred years of Alzheimer's disease research.
On the 100th anniversary of Alzheimer's lecture describing the clinicopathological entity which bears his eponym, this article reviews the major areas of progress in our understanding of the disease and outlines the many gaps still remaining. The progress toward effective mechanistic therapy is reviewed.
Hardy
John
J
Laboratory of Neurogenetics, National Institute on Aging, Porter Neuroscience Building, Bethesda, Maryland 20892, USA. hardyJ@mail.nih.gov
D000544:Alzheimer Disease / Q000235:genetics* / Q000266:history / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D012106:Research / Q000266:history; D012107:Research Design