title: Tail-induced attraction between nucleosome core particles.
abstract: We study a possible electrostatic mechanism underlying the compaction of DNA inside the nuclei of eucaryotes: the tail-bridging effect between nucleosomes, the fundamental DNA packaging units of the chromatin complex. As a simple model of the nucleosome we introduce the eight-tail colloid, a charged sphere with eight oppositely charged, flexible, grafted chains that represent the terminal histone tails. We show that our complexes attract each other via the formation of chain bridges and contrast this to the effect of attraction via charge patches. We demonstrate that the attraction between eight-tail colloids can be tuned by changing the fraction of charged monomers on the tails. This suggests a physical mechanism of chromatin compaction where the degree of DNA condensation is controlled via biochemical means, namely the acetylation and deacetylation of lysines in the histone tails.
authors.affiliation: Max-Planck-Institut für Polymerforschung, Theory Group, PO Box 3147, D-55021, Mainz, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Mühlbacher
authors.forename: H
authors.initials: H
authors.lastname: Schiessel
authors.forename: C
authors.initials: C
authors.lastname: Holm
mesh_terms: D000818:Animals; D001665:Binding Sites; D002467:Cell Nucleus / Q000737:chemistry; D002843:Chromatin / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D006801:Humans; D008954:Models, Biological; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D002843:Chromatin; D009707:Nucleosomes; D004247:DNA