title: [Case report of advanced breast cancer responding to capecitabine and trastuzumab combination therapy].
abstract: We conducted a concomitant administration of capecitabine (2,400 mg/day for 21 days followed by a 7-day interval) and trastuzumab (2 mg/kg weekly) to a 73-year-old female patient with impaired lower limb function diagnosed with bilateral breast cancer. The patient had a complete response (CR) to pulmonary metastases, and carcinoembryonic antigen (CEA) level had normalized from 46.4 ng/ml to 0.6 ng/ml. Left mastectomy was performed in order to control bleeding from tumors. No adverse events attributable to medication were observed. The concomitant administration of capecitabine and trastuzumab is a promising therapy with the potential to greatly improve patient quality of life (QOL).
authors.affiliation: Dept. of Surgery, Osaka Police Hospital.
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Yoshidome
authors.forename: Shigeru
authors.initials: S
authors.lastname: Imabun
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakahara
authors.forename: Kazuya
authors.initials: K
authors.lastname: Hiraoka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamagami
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujimoto
authors.forename: Kazuyasu
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000069287:Capecitabine; D002272:Carcinoembryonic Antigen / Q000097:blood; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008408:Mastectomy; D011788:Quality of Life; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D002272:Carcinoembryonic Antigen; D003841:Deoxycytidine; D000069287:Capecitabine; D000068878:Trastuzumab; D005472:Fluorouracil