title: A mathematical theory for temporal changes in tolerance to the behavioral effects of alcohol.
abstract: Temporal changes in the tolerance to alcohol are rarely discussed. In the behavioral theory proposed here, the rate of increase in tolerance during alcohol exposure is described by linear equations with zero intercept. These equations describe the rate of tolerance growth for acute tolerance, the rate of tolerance growth after alcohol dosing (chronic tolerance), and, for cases in which tolerance has been conditioned, the equations also describe changes in the rate of growth of tolerance when the stimulus set changes. This theory does not explain tolerance acquisition, but may be useful in investigating the physiological basis for tolerance acquisition because it provides numerical values for momentary tolerance that can be compared with concurrent physiological changes. The theory is testable and most of the published behavioral data on non-conditioned tolerance are consistent with the proposed theory. New empirical data on conditioned tolerance are needed to evaluate the proposed theory, and the design for an evaluation is suggested here. Despite its limitations, the theory serves as one example of what a mathematical theory for tolerance might be and may stimulate the development of competing theories with which it could be compared empirically.
authors.affiliation: San Diego State University, 8057 Hillandale Drive, San Diego, CA 92120-1512, USA. rradlow@sciences.sdsu.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Radlow
mesh_terms: D001519:Behavior / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008433:Mathematics
chemical_list: D000431:Ethanol