Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy.
An efficient synthesis of the C(26)-C(40) tricyclic [5,6,6]-bis-spiroacetal segment of the marine macrolide spirastrellolide A has been developed, exploiting a novel double Sharpless asymmetric dihydroxylation/spiroacetalisation sequence.
Paterson
Ian
I
University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW. ip100@cam.ac.uk
Anderson
Edward A
EA
Dalby
Stephen M
SM
Lim
Jong Ho
JH
Maltas
Philip
P
Moessner
Christian
C