Zinc phthalocyanine/magnetic fluid complex: a promising dual nanostructured system for cancer treatment.
In this study we evaluated the photophysical, photochemical properties of the zinc phthalocyanine/ magnetic fluid (ZnPC/MF) complex in liposomal medium. As a result of the present investigation we propose the liposome-encapsulated ZnPC/MF complex as a very promising nanostructured device for cancer treatment. The spectroscopy characterization and the in vitro dark toxicity of both ZnPC and ZnPC/MF complex in Hank's and in liposomal medium are reported. Our findings revealed that the spectroscopic properties of the ZnPC associated or not with MF presented little differences and are very close to what one expects from an ideal photosensitizer compound. Indeed, the ZnPC/MF complex in liposomal medium presented lower dark toxicity compared to the ZnPC/MF complex in Hank's, strongly supporting the use of the former for cancer treatment.
Oliveira
Daniela M
DM
Universidade de São Paulo, FFCLRP-USP, 14040-901 Ribeirão Preto-SP, Brazil.
Lacava
Zulmira G M
ZG
Lima
Emília C D
EC
Morais
Paulo C
PC
Tedesco
Antonio C
AC
D000818:Animals; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D008081:Liposomes / Q000737:chemistry; D008280:Magnetics; D051379:Mice; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D010778:Photochemotherapy / Q000379:methods; D013050:Spectrometry, Fluorescence; D017967:Zinc Compounds
D004337:Drug Carriers; D007211:Indoles; D054833:Isoindoles; D008081:Liposomes; D009942:Organometallic Compounds; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D010100:Oxygen; C013647:phthalocyanine