title: Conservative treatment of infantile hypertrophic pyloric stenosis with intravenous atropine sulfate does not replace pyloromyotomy.
abstract: Pyloromyotomy as described by Weber and Ramstedt has been the standard therapy for infantile hypertrophic pyloric stenosis since the 1960's and conservative therapy has been abandoned. The objective of this study was to test the effectiveness of systemic atropine applied intravenously for 7 days as a conservative therapeutic strategy and as an alternative to primary operation. Forty-two consecutive term infants with infantile hypertrophic pyloric stenosis were enrolled in the study over a period of 5 years. After confirmation of the diagnosis they all received intravenous atropine at a dose of 0.04 mg/(kg day) and increased by 0.01 mg/(kg day) up to 0.12 mg/(kg day), given as 6-8 single doses per/day. Nine pairs of parents requested that their child should be operated before completing the 7 days of medical therapy. Surgery was necessary in 8 of the remaining 33 infants (24,.2%) who did not improve after 7 days of conservative treatment. Successful treatment with i.v. atropine sulfate was achieved only in 25/33 term infants at an average maximal dose of 0.11 mg/(kg day), without any major side effects. Intravenous atropine sulfate has been considered as a potential alternative therapeutic strategy in the treatment of infantile hypertrophic pyloric stenosis. Clinical improvement however was often not seen before the 6th or 7th day of intravenous treatment. A success rate for the conservative approach of only 75% at day 7 in our study does not favour atropine therapy, in view of success rates above 95% with surgical repair.
authors.affiliation: Department of Pediatrics IV, Neonatology, Heidelberg University, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany. peter.meissner@urz.uni-heidelberg.de
authors.forename: P E
authors.initials: PE
authors.lastname: Meissner
authors.forename: G
authors.initials: G
authors.lastname: Engelmann
authors.forename: J
authors.initials: J
authors.lastname: Troeger
authors.forename: O
authors.initials: O
authors.lastname: Linderkamp
authors.forename: W
authors.initials: W
authors.lastname: Nuetzenadel
mesh_terms: D001285:Atropine / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D046248:Pyloric Stenosis, Hypertrophic / Q000188:drug therapy* / Q000601:surgery
chemical_list: D018727:Muscarinic Antagonists; D001285:Atropine