Bacterial infections: small intestine and colon.
Bacterial enteric infections exact a heavy toll on human populations, particularly among children. Despite the explosion of knowledge on the pathogenesis of enteric diseases experienced during the past decade, the number of diarrheal episodes and human deaths reported worldwide remains of apocalyptic dimensions. However, our better understanding of the pathogenic mechanisms involved in the onset of diarrhea is finally leading to preventive interventions, such as the development of enteric vaccines, that may have a significant impact on the magnitude of this human plague.
Fasano
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Division of Pediatric Gastroenterology and Nutrition, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA. afasano@umaryland.edu