Rational treatment of pulmonary infections in patients with cystic fibrosis.
The life expectancy of patients with cystic fibrosis has increased markedly during the past two decades due in large part to improved clinical care, including the use of more effective antimicrobial agents for Pseudomonas. However, the chronic lung disease of CF remains the principal cause of mortality. A growing understanding of the complex interactions between infection and inflammation has led to new approaches for treatment, including chronic use of aerosolized antibiotics, particularly tobramycin, in patients known to be colonized/infected with P. aeruginosa and anti-inflammatory treatments to slow the progression of lung disease.
Foca
M
M
Columbia University, Department of Pediatrics, Division of Pediatric Infectious Diseases, New York, New York 10032, USA.
Rajan
S
S
Saiman
L
L