title: Osteopontin dysregulation and lytic bone lesions in multiple myeloma.
abstract: Osteopontin (OPN), a secreted phosphoprotein involved in immune regulation and bone homeostasis, is a major component of bone, the natural habitat of long-lived plasma cells and multiple myeloma (MM). We show that only some MM cell lines and primary patient samples express OPN at high levels. High OPN expression inversely correlates with bone disease. When we subdivide MM into molecular subtypes, OPN is significantly upregulated in patients with maf translocations, particularly in the fraction lacking bone disease. OPN is produced in osteolytic lesions: we propose that MM-derived OPN plays a critical role in bone disease by protecting bone from destruction.
authors.affiliation: Department of Medicine, Division of Hematology and Medical Oncology, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY, USA.
authors.forename: Davide F
authors.initials: DF
authors.lastname: Robbiani
authors.forename: Kaity
authors.initials: K
authors.lastname: Colon
authors.forename: Sarah
authors.initials: S
authors.lastname: Ely
authors.forename: Scott
authors.initials: S
authors.lastname: Ely
authors.forename: Marta
authors.initials: M
authors.lastname: Chesi
authors.forename: P Leif
authors.initials: PL
authors.lastname: Bergsagel
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications*; D009363:Neoplasm Proteins / Q000032:analysis; D010014:Osteolysis / Q000209:etiology*; D053495:Osteopontin / Q000032:analysis* / Q000502:physiology; D051257:Proto-Oncogene Proteins c-maf / Q000032:analysis*; D012334:RNA, Neoplasm / Q000032:analysis; D014407:Tumor Cells, Cultured; D015854:Up-Regulation
chemical_list: C495607:MAF protein, human; D009363:Neoplasm Proteins; D051257:Proto-Oncogene Proteins c-maf; D012334:RNA, Neoplasm; D053495:Osteopontin