Long-term prognosis after coronary bypass surgery depends on interleukin 6 polymorphism and past acute infections.
We were seeking for a mutual link between the -174G>C IL6 promoter polymorphism, history of the past acute respiratory infections and the long-term post-coronary artery bypass grafting (CABG) major adverse cardiovascular events (MACE) incidence. Two hundred thirty seven post-CABG patients have been followed up for a median period of 36 months. We found that past acute infections, influenza-like illness and lack of vaccination against influenza confer a significant risk of the post-CABG MACE incidence in the -174G allele carrying patients.
Myśliwska
Jolanta
J
Wieckiewicz
Joanna
J
Hak
Lukasz
L
Siebert
Janusz
J
Rogowski
Jan
J
Szyndler
Krzysztof
K
Myśliwski
Andrzej
A
D000208:Acute Disease; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000706:statistics & numerical data*; D003327:Coronary Disease / Q000235:genetics* / Q000401:mortality / Q000601:surgery*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011183:Postoperative Complications / Q000453:epidemiology*; D011379:Prognosis; D012141:Respiratory Tract Infections / Q000453:epidemiology; D018570:Risk Assessment; D016896:Treatment Outcome
D015850:Interleukin-6