title: A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia.
abstract: Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.
authors.forename: Bianca F
authors.initials: BF
authors.lastname: Goemans
authors.forename: Christian M
authors.initials: CM
authors.lastname: Zwaan
authors.forename: Dirk
authors.initials: D
authors.lastname: Reinhardt
authors.forename: Brenda E S
authors.initials: BE
authors.lastname: Gibson
authors.forename: K
authors.initials: K
authors.lastname: Hählen
authors.forename: Gert Jan L
authors.initials: GJ
authors.lastname: Kaspers
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology; D008081:Liposomes / Q000008:administration & dosage; D008297:Male
chemical_list: D008081:Liposomes; D003630:Daunorubicin