[Identification of AGR2 protein, a novel potential cancer marker, using proteomics technologies].
A comparative analysis of the proteins in prostate tissues of the patients operated for hyperplasia (n = 7) or cancer (n = 5) was performed aiming to search for protein diagnostic markers. Differences in several minor proteins were detected using two-dimensional electrophoresis according to O'Farrel; among them, an additional protein with a molecular weight of 19 kDa and an isoelectric point of 9.0 was observed in four of the cancer cases. Mass spectrometry allowed this protein to be identified as the androgen-induced secreted protein AGR2. The possibility of using AGR2 as a diagnostic marker of prostate cancer is discussed.
Kovalev
L I
LI
Shishkin
S S
SS
Khasigov
P Z
PZ
Dzeranov
N K
NK
Kazachenko
A V
AV
Toropygin
I Iu
IIu
Mamykina
S V
SV
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008297:Male; D009088:Mucoproteins; D009363:Neoplasm Proteins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D015513:Oncogene Proteins; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000378:metabolism; D011506:Proteins / Q000032:analysis* / Q000378:metabolism; D040901:Proteomics / Q000379:methods
C502296:AGR2 protein, human; D014408:Biomarkers, Tumor; D009088:Mucoproteins; D009363:Neoplasm Proteins; D015513:Oncogene Proteins; D011506:Proteins