title: Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials.
abstract: Interdisciplinary research endeavors are directed at understanding the molecular mechanisms of neurodegenerative and chronic diseases that affect human lifestyle. Hence the potential for developing medicinal herb-derived and food plant-derived prophylactic agents directed at neurological, metabolic, cardiovascular and psychiatric disorders abounds. Oligonol is a novel technology product emanating from the oligomerization of polyphenols, typically proanthocyanidin from a variety of fruits (grapes, apples, persimmons etc.) that has optimized bioavailability. It is an optimized phenolic product containing catechin-type monomers and oligomeric proanthocyanidins, the easily absorbed forms. Typically the constituents of Oligonol are 15-20% monomers, 8-12% dimers and 5-10% trimers. Supplementation of mice with Oligonol prior to the administration of ferric-nitrilotriacetic complex (a Fenton chemistry model) significantly reduced the extent of lipid peroxidation in the kidney, brain and liver. Oligonol triggers apoptosis in the MCF-7 and MDA-MB-231 breast cancer cells through modulation of the pro-apoptotic Bcl-2 family of proteins and the MEK/ERK signaling pathway, an observation suggesting its important chemopreventive effects. The senescence-accelerated strain of mice (SAM) are models of senescence acceleration and geriatric disorders which exhibit learning and memory deficits and enhanced production or defective control of oxidative stress leading.
authors.affiliation: Faculty of Health and Social Care, London South Bank University, 103 Borough Road, London SE1 0AA, UK. aruomaoi@lsbu.ac.uk
authors.forename: Okezie I
authors.initials: OI
authors.lastname: Aruoma
authors.forename: Buxiang
authors.initials: B
authors.lastname: Sun
authors.forename: Hajime
authors.initials: H
authors.lastname: Fujii
authors.forename: Vidushi S
authors.initials: VS
authors.lastname: Neergheen
authors.forename: Theeshan
authors.initials: T
authors.lastname: Bahorun
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Kang
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Sung
mesh_terms: D000818:Animals; D001682:Biological Availability; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D018890:Chemoprevention / Q000379:methods; D019587:Dietary Supplements; D006801:Humans; D008970:Molecular Weight; D018696:Neuroprotective Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D044945:Proanthocyanidins / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D010636:Phenols; D044945:Proanthocyanidins; C514283:oligonol; C013221:proanthocyanidin; D002392:Catechin