title: The use of rocuronium and sevoflurane in acute intermittent porphyria--a case report.
abstract: Acute intermittent porphyria (AIP) is an inherited metabolic disorder caused by deficiency of porphobilinogen deaminase, an enzyme found in the synthetic pathway of heme. Acute attack of AIP may be precipitated by many factors during operation and anesthesia, including fasting, dehydration, stress, infection, and drugs. Acute attack of AIP is likely fatal. Therefore, the drugs recommended as being safe in anesthesia for porphyria patients are up-to-dately refreshed and renovated and the identification of whether a drug is safe or not is based on cumulative anecdotal experiences. Here, we report the safe use of rocuronium and sevoflurane for long exposure in a patient affected with acute intermittent porphyria.
authors.affiliation: Department of Anesthesiology, Taichung Veterans General Hospital, Taiwan, ROC.
authors.forename: Cheng-Hung
authors.initials: CH
authors.lastname: Hsieh
authors.forename: Pei-Ching
authors.initials: PC
authors.lastname: Hung
authors.forename: Chi-Tsung
authors.initials: CT
authors.lastname: Chien
authors.forename: Yi-Ru
authors.initials: YR
authors.lastname: Shih
authors.forename: Shih-Kuei
authors.initials: SK
authors.lastname: Peng
authors.forename: Hsiang-Ning
authors.initials: HN
authors.lastname: Luk
authors.forename: Tzung-Chieh
authors.initials: TC
authors.lastname: Tsai
mesh_terms: D000732:Androstanols / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D017118:Porphyria, Acute Intermittent / Q000150:complications*; D000077123:Rocuronium; D000077149:Sevoflurane
chemical_list: D000732:Androstanols; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D003473:Neuromuscular Nondepolarizing Agents; D000077149:Sevoflurane; D000077123:Rocuronium