Synthesis of the C1-C16 fragment of ionomycin using a neutral (eta3-allyl)iron complex.
Key steps in the synthesis of the C1-C16 polyketide fragment of ionomycin were the nucleophilic addition of an organocuprate to a neutral (eta3-allyl)iron complex and the construction of a beta-diketone moiety by the Rh-catalysed rearrangement of an alpha-diazo-beta-hydroxyketone.
Cooksey
John P
JP
School of Chemistry, Leeds University, Leeds, UKLS2 9JT.
Kocienski
Philip J
PJ
Li
Ying-fa
YF
Schunk
Stefan
S
Snaddon
Thomas N
TN
D000498:Allyl Compounds; D007202:Indicators and Reagents; D015759:Ionomycin / Q000138:chemical synthesis* / Q000737:chemistry*; D007501:Iron; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D000498:Allyl Compounds; D007202:Indicators and Reagents; D015759:Ionomycin; D007501:Iron