Methylazacalix[4]pyridine: en route to Zn2+-specific fluoresence sensors.
[structure: see text] Owing to the electronic nature of the bridging nitrogen atoms which can adopt different hybridizations and form various conjugations with the adjacent pyridine(s), methylazacalix[4]pyridine underwent conformation and cavity preorganization to highly selectively bind the Zn(2+) ion. Rigidification and coplanarity of the macrocyclic ring led to a great enhancement of fluorescence of the intrinsic fluorescent host molecule.
Gong
Han-Yuan
HY
Beijing National Laboratory for Molecular Sciences, Laboratory of Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Zheng
Qi-Yu
QY
Zhang
Xiao-Hang
XH
Wang
De-Xian
DX
Wang
Mei-Xiang
MX
D005453:Fluorescence; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D009942:Organometallic Compounds; D011725:Pyridines; D015032:Zinc