Leptin resistance and obesity.
The prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure. Leptin is the primary signal from energy stores and exerts negative feedback effects on energy intake. In common obesity, leptin loses the ability to inhibit energy intake and increase energy expenditure; this is termed leptin resistance. This review discusses the evidence in support of leptin resistance in mouse models and humans and the possible mechanisms of leptin resistance.
Enriori
Pablo J
PJ
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Evans
Anne E
AE
Sinnayah
Puspha
P
Cowley
Michael A
MA
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D051379:Mice; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction
D020738:Leptin