Teratoma in an adolescent with malignant transformation into embryonal rhabdomyosarcoma: case report.
BACKGROUND
The somatic type tumors are occasionally found in nonseminomatous germ cell tumors in men. These malignancies are presumed to arise from malignant transformation (MT) of teratoma or by differentiation of totipotential germ cell.


METHODS
A case of MT of germ cell tumor in 17-year-old male into embryonal rhabdomyosarcoma is described. The histopathologic diagnosis was that of embryonal rhabdomyosarcoma in which no germ cell elements were found. The germ cell origin of transformed histology is supported by cytogenetic analysis (isochromosome 12p), and elevated alpha(1)-fetoprotein. Despite intensive therapy the patient died.


CONCLUSIONS
MT of teratoma is rare entity with poor prognosis.
Sumerauer
David
D
Department of Pediatric Hematology and Oncology, Charles University, Second Medical School, University Hospital Motol, Prague, Czech Republic. david.sumerauer@lfmotol.cuni.cz
Vicha
Ales
A
Zuntova
Anna
A
Stejskalova
Eva
E
Krskova
Lenka
L
Kabickova
Edita
E
Kodet
Roman
R
Eckschlager
Tomas
T
D000293:Adolescent; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D018365:Neoplasm, Residual; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D018233:Rhabdomyosarcoma, Embryonal / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D013724:Teratoma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy