Darkness descends with two Rabs.
Over 60 distinct Rab GTPases regulate specific vesicular transport steps in the mammalian central vacuolar system. Wasmeier et al. (this issue, p. 271) reveal a redundant role for two tissue-specific Rab proteins in regulating transport to a tissue-specific lysosome-related organelle, the melanosome.
Marks
Michael S
MS
University of Pennsylvania, Philadelphia, PA 19104, USA. marksm@mail.upenn.edu
D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D020460:Melanosomes / Q000378:metabolism*; D014442:Monophenol Monooxygenase / Q000378:metabolism*; D021381:Protein Transport; D020691:rab GTP-Binding Proteins / Q000502:physiology*; D021601:trans-Golgi Network
D014442:Monophenol Monooxygenase; C466094:Rab32 protein, human; C498786:Rab38 protein, mouse; C498787:Rab38 protein, rat; D020691:rab GTP-Binding Proteins