[Effect of a novel soy fermented product enriched with isoflavones and calcium on bone tissue of rats].
The objective was to evaluate the effect of soy fermented product intake on the corporal weight and bone tissue of ovariectomized mature rats. This product was fermented with Enterococcus faecium and Lactobacillus jugurti and enriched with isoflavones and calcium. The animals were divided in 5 groups: sham-ovariectomized; ovariectomized; ovariectomized treated with soy fermented product enriched with isoflavones and calcium; ovariectomized treated with soy fermented product enriched with calcium and ovariectomized treated with non-fermented product enriched only with calcium. In order to evaluate the effect of the tested product on bone tissue (femur and tibia), the following parameters were analyzed: length; mechanical assay of three points; density (Archimedes principle); mineral content; calcium content; measure of the trabecular widths. The corporal weight of group treated with soy fermented product containing isoflavones and calcium showed no statistical difference from sham-ovariectomized group and trabecular widths tended to have larger than ovariectomized group. However, there was no significant difference to the other evaluated parameters in result of the diverse treatments. Thus, soy fermented product enriched with isoflavones and calcium inhibited the increasing of corporal weight caused by ovariectomy and revealed a tendency to trabecular protection after castration.
Bedani
Raquel
R
Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, SP, Brasil.
Rossi
Elizeu Antonio
EA
Lepera
José Salvador
JS
Wang
Charles Chenwei
CC
de Valdez
Graciela Font
GF
D000818:Animals; D001696:Biomechanical Phenomena; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002118:Calcium / Q000008:administration & dosage*; D004195:Disease Models, Animal; D016984:Enterococcus faecium / Q000737:chemistry; D005260:Female; D005269:Femur / Q000187:drug effects / Q000648:ultrastructure; D005285:Fermentation; D005527:Food, Fortified; D007529:Isoflavones / Q000008:administration & dosage*; D007778:Lactobacillus / Q000737:chemistry; D010024:Osteoporosis / Q000188:drug therapy*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000008:administration & dosage*; D013977:Tibia / Q000187:drug effects / Q000648:ultrastructure; D015014:Yogurt
D007529:Isoflavones; D030262:Soybean Proteins; D002118:Calcium