title: Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis.
abstract: OBJECTIVE
  In the present study, we evaluated the anti-inflammatory activity of Poria cocos (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model.
  
  
  METHODS
  The anti-irritative effect of PoCo was evaluated with a visual score and quantified by non-invasive bioengineering methods, namely chromametry and transepidermal water loss. Three concentrations of PoCo in base cream DAC (amphiphilic emollient; German pharmacopoeia) were tested in a 4-day repetitive irritation test using SLS.
  
  
  RESULTS
  A statistically significant anti-inflammatory activity was observed for PoCo by all three methods when applied in parallel to the induction period of ICD. Application of PoCo after induction of ICD once a day for 5 days, starting just at the end of 4 days, was without any effect.
  
  
  CONCLUSIONS
  An anti-inflammatory efficacy of PoCo on the elicitation phase of the ICD induced by repeated SLS test could be observed and quantified by three independent, non-invasive biophysical assessment parameters. This effect can be explained by its influence on pro-inflammatory enzymes, namely phospholipase A2.
authors.affiliation: Department of Dermatology, Friedrich-Schiller-University Jena, Jena, Germany.
authors.forename: S M
authors.initials: SM
authors.lastname: Fuchs
authors.forename: C
authors.initials: C
authors.lastname: Heinemann
authors.forename: S
authors.initials: S
authors.lastname: Schliemann-Willers
authors.forename: H
authors.initials: H
authors.lastname: Härtl
authors.forename: J W
authors.initials: JW
authors.lastname: Fluhr
authors.forename: P
authors.initials: P
authors.lastname: Elsner
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification* / Q000627:therapeutic use*; D017453:Dermatitis, Irritant / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D020072:Polyporales / Q000737:chemistry*; D016037:Single-Blind Method; D012867:Skin / Q000187:drug effects; D012967:Sodium Dodecyl Sulfate; D013501:Surface-Active Agents; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate