title: A probiotic strain of Lactobacillus plantarum stimulates lymphocyte responses in immunologically intact and immunocompromised mice.
abstract: Experimental evidences showing the immunomodulatory effects of probiotic microorganisms have been provided by studies on immunologically intact animals. Here we compared the immunomodulation capacity of a probiotic strain of Lactobacillus plantarum on intact and cyclophosphamide-treated BALB/c mice. Although this strain fulfilled the in vitro criteria for the selection of potentially probiotic bacteria (resistance to low pH and bile, adhesion to epithelial cells and antimicrobial activity), it was unable to establish a persistent colonization in the gastrointestinal tract after intragastric gavage. The administration of L. plantarum did not modify the cyclophosphamide-induced leukopenia, but partially restored the proliferation of spleen cells from cyclophosphamide-treated mice in response to lipopolysaccharide. Our findings show that probiotic bacteria may exert immunomodulatory effects despite a limited colonization ability and may improve the immune function damaged by immunosuppressive agents.
authors.affiliation: Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada 18071, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Bujalance
authors.forename: E
authors.initials: E
authors.lastname: Moreno
authors.forename: M
authors.initials: M
authors.lastname: Jimenez-Valera
authors.forename: A
authors.initials: A
authors.lastname: Ruiz-Bravo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001422:Bacterial Adhesion; D001647:Bile Acids and Salts; D003520:Cyclophosphamide / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D006863:Hydrogen-Ion Concentration; D016867:Immunocompromised Host; D048191:Lactiplantibacillus plantarum / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms
chemical_list: D001647:Bile Acids and Salts; D003520:Cyclophosphamide