title: Two years of continued early treatment for recent-onset schizophrenia: a randomised controlled study.
abstract: OBJECTIVE
  This random-controlled study evaluated benefits derived from continued integrated biomedical and psychosocial treatment for recent-onset schizophrenia.
  
  
  METHODS
  Fifty cases of schizophrenia of less than 2 years duration were allocated randomly to integrated or standard treatment (ST) for 2 years. ST comprised optimal pharmacotherapy and case management, while IT also included cognitive-behavioural family treatment, that incorporated skills training, cognitive-behavioural strategies for residual psychotic and non-psychotic problems and home-based crisis management. Psychopathology, functioning, hospitalisation and suicidal behaviours were assessed two monthly and a composite index, reflecting overall clinical outcome was derived.
  
  
  RESULTS
  IC proved superior to ST in reducing negative symptoms, minor psychotic episodes and in stabilising positive symptoms, but did not reduce hospital admissions or major psychotic recurrences. The composite index showed that significantly more IC patients (53%) had excellent 2-year outcomes than ST (25%).
  
  
  CONCLUSIONS
  Evidence-based treatment achieves greater clinical benefits than pharmacotherapy and case management alone for recent-onset schizophrenia.
authors.affiliation: SINTEF Health Research, Trondheim, Norway. rolf.w.grawe@sintef.no
authors.forename: R W
authors.initials: RW
authors.lastname: Grawe
authors.forename: I R H
authors.initials: IR
authors.lastname: Falloon
authors.forename: J H
authors.initials: JH
authors.lastname: Widen
authors.forename: E
authors.initials: E
authors.lastname: Skogvoll
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D003266:Continuity of Patient Care / Q000706:statistics & numerical data*; D003419:Crisis Intervention; D019033:Delivery of Health Care, Integrated; D004358:Drug Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D012559:Schizophrenia / Q000188:drug therapy / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents