Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage.
Serotonergic neurotransmission has been implicated in suicidal behavior, including inconsistent results concerning the serotonin transporter promoter polymorphism (5-HTTLPR). Here, we analyzed the 5-HTTLPR in suicide attempters (n=85). Comparing the presence of SS with SL+LL genotypes showed a significantly higher prevalence of the SS genotype in suicide attempters with high medical damage scores (chi2=9.054, df=1, p=0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination.
Wasserman
Danuta
D
The National and the Stockholm County Centre for Suicide Research and Prevention of Mental Ill-Health, Dep of the Public Health Sciences, Karolinska Institute, Stockholm, Sweden. danuta.wasserman@ki.se
Geijer
Thomas
T
Sokolowski
Marcus
M
Frisch
Amos
A
Michaelovsky
Elena
E
Weizman
Abraham
A
Rozanov
Vsevolod
V
Wasserman
Jerzy
J
D000328:Adult; D000483:Alleles; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013406:Suicide, Attempted / Q000523:psychology*
D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA