Interleukin-22 and its crystal structure.
Interleukin-22 (IL-22) is a cytokine that regulates the production of acute phase proteins of the immunological response. On binding to its cognate receptor (IL-22R1), which is associated to the interleukin-10 receptor 2 (IL-10R2), IL-22 promotes activation of signal transducer and activator of transcription (STAT) pathway and several other cellular responses. A soluble receptor termed interleukin-22 binding protein (IL-22BP) is also able to bind to IL-22 as a natural protein antagonist, and probably provides systemic regulation of IL-22 activity. This inflammatory response system is analyzed here in terms of its molecular physiology and structural assembly. Three-dimensional (3D) model of IL-22 and structural basis of its interactions with the cognate receptors are discussed.
Nagem
Ronaldo Alves Pinto
RA
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627 CEP 31270910, Belo Horizonte, MG, Brazil.
Ferreira Júnior
José Ribamar
JR
Dumoutier
Laure
L
Renauld
Jean-Christophe
JC
Polikarpov
Igor
I
D000818:Animals; D002417:Cattle; D018360:Crystallography, X-Ray; D004285:Dogs; D004606:Elephants; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007378:Interleukins / Q000737:chemistry* / Q000276:immunology*; D008253:Macaca mulatta; D051379:Mice; D008969:Molecular Sequence Data; D002679:Pan troglodytes; D011485:Protein Binding; D011487:Protein Conformation; D051381:Rats; D018123:Receptors, Interleukin / Q000276:immunology; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology; D013552:Swine; D000097043:Interleukin-22
D007378:Interleukins; D018123:Receptors, Interleukin; D000097043:Interleukin-22; C433253:IL22RA2 protein, human