e19a2 BCR-ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases.
This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR-ABL fusion transcript e19a2. This finding suggests that CML carrying mu-BCR breakpoint may exhibit a clinical course similar to typical CML.
Mondal
B C
BC
Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, Kolkata, India.
Majumdar
S
S
Dasgupta
U B
UB
Chaudhuri
U
U
Chakrabarti
P
P
Bhattacharyya
S
S
D000328:Adult; D018450:Disease Progression; D017809:Fatal Outcome; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D014158:Transcription, Genetic
D016044:Fusion Proteins, bcr-abl