Pseudomonas aeruginosa LecB is involved in pilus biogenesis and protease IV activity but not in adhesion to respiratory mucins.
Pseudomonas aeruginosa expresses two lectins which are implicated in adhesion and biofilm formation. In this study, we demonstrate that P. aeruginosa LecB is involved in pilus biogenesis and proteolytic activity. Moreover, neither lectin was involved in adhesion to human tracheobronchial mucin. We infer that some of the ascribed functions are secondary effects on other systems rather than effects of the lectins themselves.
Sonawane
Avinash
A
Department of Medicine, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.
Jyot
Jeevan
J
Ramphal
Reuben
R
D001422:Bacterial Adhesion / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D018441:Biofilms / Q000254:growth & development; D002465:Cell Movement; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D037102:Lectins / Q000235:genetics / Q000502:physiology*; D009077:Mucins / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D020543:Proteome / Q000032:analysis; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D020545:Respiratory Mucosa / Q000378:metabolism / Q000382:microbiology
D001426:Bacterial Proteins; D037102:Lectins; D009077:Mucins; D020543:Proteome; D010447:Peptide Hydrolases; C030732:protease IV