title: Synthesis and anticancer activity studies of alpha-aminoalkylated conjugated nitroalkenes.
abstract: Novel alpha-aminoalkylated conjugated nitroalkenes which inhibit human cervical cancer (HeLa) cell proliferation by binding to tubulin were synthesized by imidazole/LiCl-mediated reaction of conjugated nitroalkenes with N-tosylimines.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
authors.forename: Namrata
authors.initials: N
authors.lastname: Rastogi
authors.forename: Renu
authors.initials: R
authors.lastname: Mohan
authors.forename: Dulal
authors.initials: D
authors.lastname: Panda
authors.forename: Shaikh M
authors.initials: SM
authors.lastname: Mobin
authors.forename: Irishi N N
authors.initials: IN
authors.lastname: Namboothiri
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D009574:Nitro Compounds