The molecular physiology of human limb immobilization and rehabilitation.
This short review will identify some of the molecular signaling events that regulate atrophy during immobilization in human skeletal muscle and how prescribed exercise rehabilitation may influence these signaling events. The potential for nutritional intervention to positively modulate molecular signaling and thereby offset muscle wasting and/or accelerate rehabilitation in humans will also be considered.
Greenhaff
Paul L
PL
Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, The Medical School, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom. paul.greenaff@nottingham.ac.uk
D000818:Animals; D004032:Diet; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D007103:Immobilization; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000235:genetics* / Q000378:metabolism / Q000534:rehabilitation*