title: Ocular complications in heart, lung and heart-lung recipients.
abstract: OBJECTIVE
  To prospectively assess ocular morbidity and the need for ocular screening in patients on long term, high dose immunosuppression for the maintenance of solid organ transplants.
  
  
  METHODS
  Dilated ocular examinations were performed on patients receiving immunosuppression for the maintenance of heart, lung and heart-lung transplants. Patients were examined repeatedly in the post transplant period.
  
  
  RESULTS
  Of the 115 transplant recipients examined 62 (54%) had ocular findings. The most common findings were cataracts (17% of those examined) followed by hypertensive change (8%), chorioretinal scarring (5%) and diabetic retinopathy (3%). One patient developed ocular infective complications following surgery due to Aspergillus spp. endophthalmitis. 18 patients (16%) were symptomatic at examination with the most common symptom being blurred vision. The most common finding in symptomatic patients was cataract with almost a quarter of patients having posterior subcapsular lens opacity that could be attributed to steroid therapy.
  
  
  CONCLUSIONS
  Patients had surprising low incidences of ocular infective complications despite previous reports. It is likely that this is due to improved immunosuppression regimes and improved monitoring of immunosuppression in the early post-transplant period. The screening of asymptomatic individuals following heart, lung or heart-lung transplantation was not supported by this study.
authors.affiliation: Department of Clinical Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK. t.akerele@doctors.org.uk
authors.forename: Toks
authors.initials: T
authors.lastname: Akerele
authors.forename: Susan
authors.initials: S
authors.lastname: Lightman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002386:Cataract / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology*; D015817:Eye Infections / Q000209:etiology; D005260:Female; D016027:Heart Transplantation; D016041:Heart-Lung Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000209:etiology; D011182:Postoperative Care / Q000009:adverse effects; D011183:Postoperative Complications; D011446:Prospective Studies; D012164:Retinal Diseases / Q000209:etiology