Nonalcoholic fatty liver disease and obesity.
OBJECTIVE
The aim of this review is to update concepts of the nonalcoholic fatty liver disease (NAFLD) and to establish a relationship between this condition and obesity.


METHODS
By means of a comprehensive literature review where special attention was devoted to articles published in the last 5 years, NAFLD is discussed in view of new concepts, diagnosis, staging, and treatment.


RESULTS
NAFLD is emerging as one of the main causes of chronic liver disease and it is believed to be the hepatic component of the metabolic syndrome, whose central features include obesity, hyperinsulinemia, peripheral insulin resistance, diabetes, dyslipidemia, and hypertension. The surgical treatment of morbid obesity is one of the options available for the treatment of NAFLD.


CONCLUSIONS
Nonalcoholic fatty liver disease is strongly related with obesity.
Salgado Júnior
Wilson
W
Division of Gastroenterology, Department of Surgery and Anatomy, FMRP, USP, Brazil.
Santos
José Sebastião dos
JS
Sankarankutty
Ajith Kumar
AK
Silva
Orlando de Castro e
Ode C
D000328:Adult; D050110:Bariatric Surgery; D001706:Biopsy; D005234:Fatty Liver / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology; D008297:Male; D009765:Obesity / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D009767:Obesity, Morbid / Q000150:complications / Q000473:pathology; D012720:Severity of Illness Index