[The effect of shanzha xiaozhi capsule on the blood lipid and the function of endothelial cells in patients with dislipide mia].
OBJECTIVE
To explore the Mechanism of Shanzha xiaozhi Capsule improving the functions of endonthelial cells in patients with dislipide mia.


METHODS
To measurate the blood lipid and the levels of plasma Endothelin (ET) and nitrodi oxide (NO) in 30 patients with dislipide mia before and after taking the Shanzha xiaozhi Capsule, and there were 10 normal persons in control group, which were measured the blood lipid and the levels of ET and NO only one time.


RESULTS
After treatment with Shanzha xiaozhi Capsule, the levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholestero (LDL-C), ET were markedly reduced (P < 0.05), and the levels of NO were obviously elevated (P < 0.05).


CONCLUSIONS
Shanzha xiaozhi Capsule can reduce blood lipid level and the plasma ET levels, increase the NO levels and the protection to the functions of endothelial cells which might be involved in the mechanisms of against atherosclerosis.
Zhao
Hua-yun
HY
Cardiovascular Internal Medicine, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China.
Wang
Wen-hui
WH
D050197:Atherosclerosis / Q000517:prevention & control; D002214:Capsules; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
D002214:Capsules; D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides; D009569:Nitric Oxide; D002784:Cholesterol