title: The use of evolutionary biology concepts for genome annotation.
abstract: The past decade has seen the completion of numerous whole-genome sequencing projects, began with bacterial genomes and continued with eukaryotic species from different phyla: fungi, plants and animals. Besides, more biological information are produced and are shared thanks to information exchange systems, and more biological concepts, as well as more bioinformatics tools, are available. In this article, we will describe how the evolutionary biology concepts, as well as computer science, are useful for a better understanding of biology in general and genome annotation in particular. The genome annotation process consists of taking the raw DNA produced, for example, by the genome sequencing projects, adding the layers of analysis and interpretation necessary to extract its biological significance and placing it in the context of our understanding of biological processes. Genome annotation is a multistep process falling into two broad categories: structural and functional annotation.
authors.affiliation: Glycogenomics and Biomedical Structural Biology, AFMB Laboratory, UMR 6098, CNRS, Universités d'Aix-Marseille I et II, 13288 Marseille, France.
authors.forename: Etienne G J
authors.initials: EG
authors.lastname: Danchin
authors.forename: Anthony
authors.initials: A
authors.lastname: Levasseur
authors.forename: Virginie Lopez
authors.initials: VL
authors.lastname: Rascol
authors.forename: Philippe
authors.initials: P
authors.lastname: Gouret
authors.forename: Pierre
authors.initials: P
authors.lastname: Pontarotti
mesh_terms: D000595:Amino Acid Sequence; D005075:Biological Evolution; D019295:Computational Biology / Q000379:methods*; D005786:Gene Expression Regulation; D016678:Genome; D023281:Genomics / Q000379:methods*