title: Dose-related effects of prolonged NaHCO3 ingestion during high-intensity exercise.
abstract: OBJECTIVE
  Sodium bicarbonate (NaHCO3) ingestion may prevent exercise-induced perturbations in acid-base balance, thus resulting in performance enhancement. This study aimed to determine whether different levels of NaHCO3 intake influences acid-base balance and performance during high-intensity exercise after 5 d of supplementation.
  
  
  METHODS
  Twenty-four men (22 +/- 1.7 yr) were randomly assigned to one of three groups (eight subjects per group): control (C, placebo), moderate NaHCO3 intake (MI, 0.3 g x kg(-1) x d(-1)), and high NaHCO3 intake (HI, 0.5 g x kg(-1) x d(-1)). Arterial pH, HCO3(-), PO2, PCO2, K+, Na, base excess (BE), lactate, and mean power (MP) were measured before and after a Wingate test pre- and postsupplementation.
  
  
  RESULTS
  HCO3(-) increased proportionately to the dosage level. No differences were detected in C. Supplementation increased MP (W x kg(-)) in MI (7.36 +/- 0.7 vs 6.73 +/- 1.0) and HI (7.72 +/- 0.9 vs 6.69 +/- 0.6), with HI being more effective than MI. NaHCO3 ingestion resulted postexercise in increased lactate (mmol x L(-1)) (12.3 +/- 1.8 vs 10.3 +/- 1.9 and 12.4 +/- 1.2 vs 10.4 +/- 1.5 in MI and HI, respectively), reduced exercise-induced drop of pH (7.305 +/- 0.04 vs 7.198 +/- 0.02 and 7.343 +/- 0.05 vs 7.2 +/- 0.01 in MI and HI, respectively) and HCO3(-) (mmol x L(-1)) (13.1 +/- 2.4 vs 17.5 +/- 2.8 and 13.2 +/- 2.7 vs 19.8 +/- 3.2 for HCO3 in MI and HI, respectively), and reduced K (3.875 +/- 0.2 vs 3.625 +/- 0.3 mmol x L(-1) in MI and HI, respectively).
  
  
  CONCLUSIONS
  NaHCO3 administration for 5 d may prevent acid-base balance disturbances and improve performance during anaerobic exercise in a dose-dependent manner.
authors.affiliation: Democritus University of Thrace, Department of Physical Education & Sport Science, Komotini, Greece.
authors.forename: Ioannis I
authors.initials: II
authors.lastname: Douroudos
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Fatouros
authors.forename: Vassilios
authors.initials: V
authors.lastname: Gourgoulis
authors.forename: Athanasios Z
authors.initials: AZ
authors.lastname: Jamurtas
authors.forename: Tilemaxos
authors.initials: T
authors.lastname: Tsitsios
authors.forename: Athanasios
authors.initials: A
authors.lastname: Hatzinikolaou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Margonis
authors.forename: Kontantinos
authors.initials: K
authors.lastname: Mavromatidis
authors.forename: Kiriakos
authors.initials: K
authors.lastname: Taxildaris
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000140:Acidosis, Lactic; D000328:Adult; D000471:Alkalosis / Q000139:chemically induced; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D017693:Sodium Bicarbonate / Q000008:administration & dosage / Q000494:pharmacology*; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D017693:Sodium Bicarbonate