title: Neural correlates of epigenesis.
abstract: The effect of life stress on depression is moderated by a repeat length variation in the transcriptional control region of the serotonin transporter gene, which renders carriers of the short variant vulnerable for depression. We investigated the underlying neural mechanisms of these epigenetic processes in individuals with no history of psychopathology by using multimodal magnetic resonance-based imaging (functional, perfusion, and structural), genotyping, and self-reported life stress and rumination. Based on functional MRI and perfusion data, we found support for a model by which life stress interacts with the effect of serotonin transporter genotype on amygdala and hippocampal resting activation, two regions involved in depression and stress. Life stress also differentially affected, as a function of serotonin transporter genotype, functional connectivity of the amygdala and hippocampus with a wide network of other regions, as well as gray matter structural features, and affected individuals' level of rumination. These interactions may constitute a neural mechanism for epigenetic vulnerability toward, or protection against, depression.
authors.affiliation: Department of Psychology Stony Brook University, Stony Brook, NY 11794-2500, USA. turhan.canli@sunysb.edu
authors.forename: Turhan
authors.initials: T
authors.lastname: Canli
authors.forename: Maolin
authors.initials: M
authors.lastname: Qiu
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Omura
authors.forename: Eliza
authors.initials: E
authors.lastname: Congdon
authors.forename: Brian W
authors.initials: BW
authors.lastname: Haas
authors.forename: Zenab
authors.initials: Z
authors.lastname: Amin
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Herrmann
authors.forename: R Todd
authors.initials: RT
authors.lastname: Constable
authors.forename: Klaus Peter
authors.initials: KP
authors.lastname: Lesch
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation; D003863:Depression / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D008297:Male; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin