title: Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI.
abstract: Rapid T(1)-weighted 3D spoiled gradient-echo (GRE) data sets were acquired in the abdomen of 23 cancer patients during a total of 113 separate visits to allow dynamic contrast-enhanced MRI (DCE-MRI) analysis of tumor microvasculature. The arterial input function (AIF) was measured in each patient at each visit using an automated AIF extraction method following a standardized bolus administration of gadodiamide. The AIFs for each patient were combined to obtain a mean AIF that is representative for any individual. The functional form of this general AIF may be useful for studies in which AIF measurements are not possible. Improvements in the reproducibility of DCE-MRI model parameters (K(trans), v(e), and v(p)) were observed when this new, high-temporal-resolution population AIF was used, indicating the potential for increased sensitivity to therapy-induced change.
authors.affiliation: Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK. geoff.parker@manchester.ac.uk
authors.forename: Geoff J M
authors.initials: GJ
authors.lastname: Parker
authors.forename: Caleb
authors.initials: C
authors.lastname: Roberts
authors.forename: Andrew
authors.initials: A
authors.lastname: Macdonald
authors.forename: Giovanni A
authors.initials: GA
authors.lastname: Buonaccorsi
authors.forename: Sue
authors.initials: S
authors.lastname: Cheung
authors.forename: David L
authors.initials: DL
authors.lastname: Buckley
authors.forename: Alan
authors.initials: A
authors.lastname: Jackson
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Watson
authors.forename: Karen
authors.initials: K
authors.lastname: Davies
authors.forename: Gordon C
authors.initials: GC
authors.lastname: Jayson
mesh_terms: D000008:Abdominal Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001158:Arteries / Q000473:pathology / Q000503:physiopathology; D003198:Computer Simulation; D003287:Contrast Media; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015233:Models, Statistical; D010386:Pelvic Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA