title: Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: implications for future trials.
abstract: Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 x 10(7)pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies.
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: De Rose
authors.forename: Mark T
authors.initials: MT
authors.lastname: Sullivan
authors.forename: C Jane
authors.initials: CJ
authors.lastname: Dale
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Kelleher
authors.forename: Sean
authors.initials: S
authors.lastname: Emery
authors.forename: David A
authors.initials: DA
authors.lastname: Cooper
authors.forename: Ian A
authors.initials: IA
authors.lastname: Ramshaw
authors.forename: David B
authors.initials: DB
authors.lastname: Boyle
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kent
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D001830:Body Surface Area; D004306:Dose-Response Relationship, Immunologic; D005587:Fowlpox virus / Q000235:genetics*; D006801:Humans; D008251:Macaca; D019444:Vaccines, DNA / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic