[Desensitization to cotrimoxazole, rifampicin and penicillin G in nine patients with prior hypersensitivity].
OBJECTIVE
To present a protocol for the administration and development technique of the desensitization regimens for cotrimoxazole, rifampicin and penicillin G hypersensibility.


METHODS
A review of the available desensitization protocols for these antibiotics and a retrospective study of desensitization processes undertaken in the center from 1998. A development technique of the antibiotic dosages was designed.


RESULTS
Desensitization regimens for cotrimoxazole, rifampicin and penicillin G undertaken in the center in 9 patients came from a protocol by Glucksteins et al., Holland et al. and Wendal et al., respectively. After the literature review and the satisfactory results that allowed subsequent antibiotic administration in the 9 cases, these regimens were established as protocols of the center.


CONCLUSIONS
Dosage development and patient administration have a practical application and can help to decrease the potential mistakes related to the complexity of the process.
Pujal Herranz
M
M
Servicio de Farmacia, Hospital Clínic, Barcelona. meritxell.pujal@gmail.com
Roca Massa
M
M
Domínguez Tordera
P
P
Codina Jané
C
C
Ribas Sala
J
J
D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000276:immunology; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology / Q000628:therapy*; D006801:Humans; D010400:Penicillin G / Q000009:adverse effects* / Q000276:immunology; D012189:Retrospective Studies; D012293:Rifampin / Q000009:adverse effects / Q000276:immunology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000276:immunology
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D010400:Penicillin G; D012293:Rifampin