title: Two system-size-resonance behaviors for calcium signaling: for optimal cell size and for optimal network size.
abstract: We have studied the collective calcium signaling behavior of an array of coupled N cells, taking into account the internal noises resulting from the small cell size V. The system's performance was characterized by the reciprocal coefficient of variance (RCV) of the calcium spike train. Two system-size resonances were observed, namely, the RCV value shows a clear peak when both N and V are optimal. Therefore, an optimal number of cells of optimal size work the best as a whole.
authors.affiliation: Hefei National Laboratory for Physical Science at Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. hzhlj@ustc.edu.cn
authors.forename: Zhonghuai
authors.initials: Z
authors.lastname: Hou
authors.forename: Jiqian
authors.initials: J
authors.lastname: Zhang
authors.forename: Houwen
authors.initials: H
authors.lastname: Xin
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D048429:Cell Size; D004721:Endoplasmic Reticulum / Q000502:physiology; D022781:Hepatocytes / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D013269:Stochastic Processes