title: Effects of sevoflurane on biomechanical markers of hepatic and renal dysfunction after coronary artery surgery.
abstract: OBJECTIVE
  The purpose of this study was to compare the effects of a total intravenous and a volatile anesthetic regimen on biochemical markers of hepatic and renal dysfunction after coronary artery surgery.
  
  
  METHODS
  Prospective, double-blind, randomized clinical study.
  
  
  METHODS
  University hospital, single institutional.
  
  
  METHODS
  Three hundred twenty patients undergoing elective coronary artery surgery were divided into 2 different anesthetic protocols: propofol group (n = 160) and sevoflurane group (n = 160).
  
  
  METHODS
  Hemodynamic data were registered before the start of surgery, before the start of CPB, 15 minutes after the end of CPB, at arrival in the intensive care unit, and 6 and 12 hours after arrival in the intensive care unit. Serum glutamic oxaloacetic transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum lactate dehydrogenase (LDH), and serum creatinine concentrations were measured before surgery, at arrival in the intensive care unit, and after 6, 12, 24, and 48 hours.
  
  
  RESULTS
  Postoperative levels of serum SGOT, SGPT, and LDH increased transiently in both anesthetic groups, but the increase was significantly lower in the sevoflurane group compared with the propofol group. Creatinine levels remained largely unchanged in both groups.
  
  
  CONCLUSIONS
  Postoperative biochemical markers of hepatic dysfunction were lower with a sevoflurane-based anesthetic regimen in patients undergoing coronary artery surgery with cardiopulmonary bypass.
authors.affiliation: Department of Anesthesiology, University Hospital, Antwerp, Edegem, Belgium.
authors.forename: Suraphong
authors.initials: S
authors.lastname: Lorsomradee
authors.forename: Stefanie
authors.initials: S
authors.lastname: Cromheecke
authors.forename: Sratwadee
authors.initials: S
authors.lastname: Lorsomradee
authors.forename: Stefan G
authors.initials: SG
authors.lastname: De Hert
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000768:Anesthesia, General / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002315:Cardiopulmonary Bypass / Q000379:methods; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003327:Coronary Disease / Q000097:blood / Q000601:surgery*; D003404:Creatinine / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000209:etiology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008107:Liver Diseases / Q000097:blood* / Q000209:etiology; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D011379:Prognosis; D011446:Prospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D015415:Biomarkers; D008738:Methyl Ethers; D000077149:Sevoflurane; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase