[Serum angiogenin concentration in nasopharyngeal carcinoma patients and its clinical significance].
OBJECTIVE
To determine the serum angiogenin (ANG) concentration in patients with nasopharyngeal carcinoma (NPC) and analyze its clinical significance.


METHODS
Forty-two NPC patients and 30 healthy controls entered this study. Serum ANG level was quantitatively analyzed by enzyme-linked immunosorbent assay (ELISA).


RESULTS
The mean level of serum ANG in untreated NPC was (371.4 +/- 123.5) microg/L, which was significantly higher than that in healthy controls(292.5 +/- 74.2) microg/L (P < 0.01). Furthermore, the serum level of ANG increased with the development of tumor (P < 0.05). After treatment, all patients reached a response: partial response (PR) or complete response (PR), and the serum ANG level was (340.6 +/- 112.4) microg/L, which was significantly lower than that in untreated ones (P < 0.05), but still higher than that in healthy controls (P < 0.05).


CONCLUSIONS
Our results indicate that the serum ANG level increases in patients with NPC, and is correlate with primary tumor progression.
Xia
Bing
B
Department of Medical Research, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China. xiab1972@163.com
Yang
Taicheng
T
Xian
Jiang
J
Wang
Jie
J
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000097:blood* / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012259:Ribonuclease, Pancreatic / Q000097:blood*
C046366:angiogenin; D012259:Ribonuclease, Pancreatic