Perceptual correlate of nociceptive long-term potentiation (LTP) in humans shares the time course of early-LTP.
As in neocortex and hippocampus, neurons in the dorsal horn of the spinal cord develop long-term potentiation of synaptic efficacy (LTP) on high-frequency stimulation (HFS) of their afferent input, although how long LTP lasts in this nociceptive relay nucleus has not yet been addressed. Here we studied neurogenic hyperalgesia, a perceptual correlate of nociceptive LTP, in 13 healthy subjects, after HFS (5 x 1 s at 100 Hz) of superficial cutaneous afferents. HFS led to a mean upward shift of the stimulus-response function for pinprick-evoked pain (punctate mechanical hyperalgesia) in all subjects by a factor of 2.5 (P < 0.001) that lasted undiminished for the initial 1-h observation period. Follow-up tests until the next day revealed that this type of neurogenic hyperalgesia decayed with a t(1/2) of 3.3 h (99% CI: 3.1-3.5 h) and disappeared completely within 25.4 h (99% CI: 20.4-31.6 h). Touch-evoked pain (dynamic mechanical allodynia) developed in eight of 13 subjects, decayed with a t(1/2) of 2.9 h from the maximum and disappeared within 9.3 h. These findings suggest that a single HFS session induces nociceptive LTP in healthy subjects that corresponds to early-LTP (LTP1), implying primarily posttranslational mechanisms for this type of plasticity of human pain perception.
Klein
Thomas
T
Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstrasse 21, D-55099 Mainz, Germany.
Magerl
Walter
W
Treede
Rolf-Detlef
RD
D000328:Adult; D003213:Conditioning, Psychological; D003627:Data Interpretation, Statistical; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000523:psychology*; D010147:Pain Measurement; D010812:Physical Stimulation; D014796:Visual Perception / Q000502:physiology*