title: Pressure affects transcription profiles of Methanocaldococcus jannaschii despite the absence of barophilic growth under gas-transfer limitation.
abstract: Barophilic growth of the hyperthermophilic methanarchaeon Methanocaldococcus jannaschii occurred when gas-substrate availability did not limit growth. In contrast, when growth was limited by gas transfer, no enhancement of growth was evident and a stress response was exhibited at both high and low pressure. A pressure-induced transcriptional response was evident, regardless of whether growth was enhanced by pressure. Potential high-pressure adaptation of a barophilic organism can thus occur at the transcriptional level, even though the cells are stressed by low substrate availability and do not exhibit accelerated growth.
authors.affiliation: Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA.
authors.forename: Boonchai
authors.initials: B
authors.lastname: Boonyaratanakornkit
authors.forename: Jesús
authors.initials: J
authors.lastname: Córdova
authors.forename: Chan Beum
authors.initials: CB
authors.lastname: Park
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Clark
mesh_terms: D019149:Bioreactors; D020869:Gene Expression Profiling; D017017:Methanococcus / Q000235:genetics* / Q000254:growth & development*; D011312:Pressure; D014158:Transcription, Genetic