title: [From thrombin hypothesis to inflammation. Is it reality?].
abstract: The classical pathophysiologic concept of the acute coronary syndromes is the coronary artery thrombosis as a consequence of rupture or vulnerable atherosclerotic plaques. Actually, it is also been considered that systemic inflammatory phenomenon play a central role in the plaque instability associated to the atherothrombotic activity of the tissue factor (TF). The thrombotic phenomenon is controlled by tissue factor, stimulating the way of the protease's active receptors (PAR) and cause a negative cycle between inflammation and coagulation.
authors.affiliation: Unidad de Cuidados Coronarios, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan, DF México.
authors.forename: Héctor
authors.initials: H
authors.lastname: González Pacheco
mesh_terms: D000208:Acute Disease; D000789:Angina, Unstable / Q000209:etiology*; D003324:Coronary Artery Disease / Q000150:complications; D006801:Humans; D007249:Inflammation / Q000150:complications*; D009203:Myocardial Infarction / Q000209:etiology*; D013577:Syndrome; D013917:Thrombin / Q000502:physiology*
chemical_list: D013917:Thrombin