title: [Histopathological diagnostics in endoprosthesis loosening].
abstract: The implantation of total joint endoprostheses has become a routine procedure, being executed about 1.5 million times per year worldwide. The indications are osteoarthritis, rheumatic diseases, trauma and bone neoplasia. However, about 5-12% of patients develop pain and impaired function of the endoprosthesis within 10 years, necessitating revision surgery. During this operation, the so-called periprosthetic membrane between bone and prosthesis is removed. This connective tissue membrane has a pathogenetic impact on the loosening process and can be evaluated by histopathology. This article aims at elucidating the defined histomorphological criteria for the standardized diagnostics of periprosthetic membranes using a recently established classification system.
authors.affiliation: Institut für Pathologie, Charité Universitätsmedizin, Berlin. lars.morawietz@charite.de
authors.forename: L
authors.initials: L
authors.lastname: Morawietz
authors.forename: T
authors.initials: T
authors.lastname: Gehrke
authors.forename: J H
authors.initials: JH
authors.lastname: Schröder
authors.forename: V
authors.initials: V
authors.lastname: Krenn
mesh_terms: D000368:Aged; D019643:Arthroplasty, Replacement / Q000009:adverse effects; D006801:Humans; D007592:Joint Diseases / Q000473:pathology* / Q000601:surgery*; D011475:Prosthesis Failure