title: [Berylliosis in Italy: a case of "sarcoidosis" under the threshold limit value].
abstract: BACKGROUND
  Berylliosis is caused by a chronic immune reaction to beryllium; in Italy the first case of beryllium exposure-related disease was described in 1935 by Fabroni-Marradi and two additional cases of beryllium disease were subsequently described by Ambrosi and co-workers in 1968. No case has since been recognized using the standardized criteria including immunological testing.
  
  
  OBJECTIVE
  To describe a case report of clinically significant berylliosis that occurred in a man exposed to beryllium for ten years in the workplace at concentrations below the permitted threshold limit value.
  
  
  METHODS
  The man complained of dyspnoea, dry cough, weakness and weight loss for the past year and was at first diagnosed as suffering from sarcoidosis because of increased angiotensin converting enzyme levels, alteration of hepatic and renal functional indexes, the presence of diffused reticulo-nodular lung abnormalities with high resolution computed tomography that also showed enlarged mediastinal lymph nodes, abnormal lung physiology with reduced diffusion capacity and a bronchial biopsy showing granulomatous lesions. Because of the occupational history immunological testing and high resolution HLA class II typing were performed.
  
  
  RESULTS
  The high response to beryllium in the lymphocytes proliferation test and the HLA typing which revealed the presence of the two susceptibility markers HLA-DPGlu69 and HLA-DRPhe47 led to a diagnosis of berylliosis.
  
  
  CONCLUSIONS
  The importance is stressed of suspecting a diagnosis of berylliosis in the proper occupational contexts and encouraging the use of immunological tests for diagnosis, and also the need for critical revision of the permitted threshold limit values.
authors.affiliation: Dipartimento di Medicina Interna, Università degli Studi di Roma Tor Vergata, Roma.
authors.forename: Silvia
authors.initials: S
authors.lastname: Contini
authors.forename: G
authors.initials: G
authors.lastname: Mattioli
authors.forename: Floriana
authors.initials: F
authors.lastname: Berretta
authors.forename: A
authors.initials: A
authors.lastname: Bergamaschi
authors.forename: Franca
authors.initials: F
authors.lastname: Sullotto
authors.forename: Antonella
authors.initials: A
authors.lastname: Spigo
authors.forename: P
authors.initials: P
authors.lastname: Verniano
authors.forename: M
authors.initials: M
authors.lastname: Amicosante
mesh_terms: D000328:Adult; D001607:Berylliosis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis