title: Synthetic studies on the MARDi cascade: stereoselective synthesis of heterocyclic seven-membered rings.
abstract: [reaction: see text] A versatile stereoselective synthesis of substituted and functionalized heterocyclic seven-membered rings is described. The approach involves a formal two-carbon ring expansion of heterocyclic cyclopentanones through a base-induced anionic domino three-component transformation named the MARDi cascade leading either to oxa-, aza-, or thiacycloheptanes bearing up to five contiguous stereogenic centers.
authors.affiliation: Université Paul Cézanne (Aix-Marseille III), UMR CNRS 6178, Centre universitaire de St Jérôme, boîte D12, 13397 Marseille Cedex 20, France.
authors.forename: Yoann
authors.initials: Y
authors.lastname: Coquerel
authors.forename: David
authors.initials: D
authors.lastname: Bensa
authors.forename: Alain
authors.initials: A
authors.lastname: Doutheau
authors.forename: Jean
authors.initials: J
authors.lastname: Rodriguez