Growth control: p53, the guardian angel of compensatory proliferation.
Compensatory growth, or regeneration, is used to replace damaged tissue during animal development. Recent work has revealed a new role for Drosophila p53 in the compensatory proliferation of cells that are needed to repair damaged tissues, a role that requires the non-apoptotic function of the caspase protease Dronc.
Baehrecke
Eric H
EH
Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA. baehreck@umbi.umd.edu
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D020169:Caspases / Q000502:physiology; D049109:Cell Proliferation; D004249:DNA Damage; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D012038:Regeneration; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*
D029721:Drosophila Proteins; D016159:Tumor Suppressor Protein p53; C474203:p53 protein, Drosophila; D020169:Caspases; C118731:dronc protein, Drosophila