title: Activity of DX-619 compared to other agents against viridans group streptococci, Streptococcus bovis, and Cardiobacterium hominis.
abstract: Against 198 viridans group streptococci, 25 Streptococcus bovis strains, and 5 Cardiobacterium hominis strains, MICs of DX-619, a des-F(6)-quinolone, were between 0.004 and 0.25 microg/ml. These MICs were lower than those of other quinolones (< or = 0.008 to > 32 microg/ml). Beta-lactam MICs were between < or = 0.008 and 16 microg/ml. Azithromycin resistance was found in most species, while most were telithromycin susceptible. Glycopeptides and linezolid were active against viridans group strains but inactive against C. hominis.
authors.affiliation: Hershey Medical Center, Hershey, PA 17033, USA.
authors.forename: Klaudia
authors.initials: K
authors.lastname: Kosowska-Shick
authors.forename: Kathy
authors.initials: K
authors.lastname: Smith
authors.forename: Tatiana
authors.initials: T
authors.lastname: Bogdanovich
authors.forename: Lois M
authors.initials: LM
authors.lastname: Ednie
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D044066:Cardiobacterium / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D006017:Glycolipids / Q000494:pharmacology; D048628:Ketolides / Q000494:pharmacology; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D016985:Streptococcus bovis / Q000187:drug effects*; D034363:Viridans Streptococci / Q000187:drug effects*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; C505440:DX 619; D006017:Glycolipids; D048628:Ketolides; D023303:Oxazolidinones; D011759:Pyrrolidines; D015363:Quinolones; D047090:beta-Lactams; D017963:Azithromycin; D000069349:Linezolid; C106791:telithromycin