Characterization of HLA-B*5516, -B*1313, -B*9512, and -DRB1*1457 alleles identified in a southwest Chinese population.
The human leukocyte antigen (HLA)-B*5516 allele differs from the B*5502 by a single 97 T --> C substitution (His to Tyr at position 33) in exon 2. The B*1313 allele results from 419 T --> A and 420 A --> C substitutions, encoding a Leu to Tyr substitution at 140 in exon 2 of the B*1301 allele. The B*9512 allele differs from B*1502 by a single 360 G --> C substitution (Gln to His at 120) in exon 3. The DRB1*1457 allele appears to be a hybrid molecule generated by recombination between the DRB1*13 and DRB1*14 alleles. The serological equivalents of these new alleles are HLA-B22, -B13, -B15, and DR13, respectively. Family studies detected two rare haplotypes: A*11, B*9512, DRB1*14 and A*24, B*52, Cw*07, DRB1*1457, DRB3*020201, DQB1*050301. The gene frequencies of these alleles in the Chinese population are less than 0.0001.
Chen
Q
Q
Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China. xiet@mail.sc.cninfo.net
Zou
H
H
Xu
X H
XH
Luo
M
M
Wang
J
J
Zuo
Y Q
YQ
Chen
Y H
YH
Chen
X H
XH
Chen
X L
XL
Yao
Z Q
ZQ
Song
N
N
Zeng
J
J
Mi
X Y
XY
Sun
S X
SX
Wang
J X
JX
Zhao
T M
TM
D000483:Alleles; D000595:Amino Acid Sequence; D000906:Antibodies / Q000097:blood; D000918:Antibody Specificity / Q000235:genetics; D044466:Asian People / Q000235:genetics; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D005838:Genotype; D015235:HLA-B Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D000906:Antibodies; D000939:Epitopes; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains