title: Intrathecal donor lymphocyte infusion for the treatment of suspected refractory lymphomatous meningitis: a case report.
abstract: A 43-year-old female with large T-cell non-Hodgkin's lymphoma and central nervous system (CNS) involvement underwent HLA-identical-sibling peripheral blood stem cell transplantation (SCT) during her third complete remission. She presented a possible refractory CNS relapse 5 months after the transplant. She was then treated with intrathecal (IT) donor lymphocyte infusions (DLI). No side effects were observed after three DLI injections. The patient died 13 months later from infectious complications with no evidence of progressive disease. To our knowledge, this is the first case report of IT DLI for possible refractory lymphomatous meningitis.
authors.affiliation: Department of Clinical and Expreimental Haematology, Institute Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium. nathalie.meuleman@bordet.be
authors.forename: N
authors.initials: N
authors.lastname: Meuleman
authors.forename: I
authors.initials: I
authors.lastname: Ahmad
authors.forename: H
authors.initials: H
authors.lastname: Duvillier
authors.forename: M
authors.initials: M
authors.lastname: Lemort
authors.forename: J
authors.initials: J
authors.lastname: Bennani
authors.forename: M
authors.initials: M
authors.lastname: Martiat
authors.forename: L
authors.initials: L
authors.lastname: Lagneaux
authors.forename: D
authors.initials: D
authors.lastname: Bron
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007278:Injections, Spinal; D015850:Interleukin-6 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis; D017710:Lymphocyte Transfusion; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008581:Meningitis / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D012074:Remission Induction; D033581:Stem Cell Transplantation
chemical_list: D006680:HLA Antigens; D015850:Interleukin-6; D016209:Interleukin-8