Viral ion channel proteins in model membranes: a comparative study by X-ray reflectivity.
We have investigated the effect of the transmembrane domain of three viral ion channel proteins on the lipid bilayer structure by X-ray reflectivity and scattering from oriented planar bilayers. The proteins show a similar effect on the lipid bilayer structural parameters: an increase in the lipid bilayer hydrophobic core, a decrease in the amplitude of the vertical density profile and a systematic change in the ordering of the acyl chains as a function of protein-to-lipid ratio. These results are discussed in a comparative view.
Khattari
Z
Z
Institut für Röntgenphysik, Universität Göttingen Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.
Arbely
E
E
Arkin
I T
IT
Salditt
T
T
D015497:HIV-1 / Q000378:metabolism; D054298:Human Immunodeficiency Virus Proteins; D009980:Influenza A virus / Q000235:genetics; D007473:Ion Channels / Q000737:chemistry*; D007477:Ions; D008051:Lipid Bilayers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry; D008560:Membrane Fluidity; D008954:Models, Biological; D010455:Peptides / Q000737:chemistry; D045473:Severe acute respiratory syndrome-related coronavirus / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014759:Viral Envelope Proteins / Q000737:chemistry; D054334:Viral Regulatory and Accessory Proteins / Q000737:chemistry; D014965:X-Rays; D000086082:Viroporin Proteins
D054298:Human Immunodeficiency Virus Proteins; D007473:Ion Channels; D007477:Ions; D008051:Lipid Bilayers; D008055:Lipids; D010455:Peptides; D014759:Viral Envelope Proteins; D054334:Viral Regulatory and Accessory Proteins; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins