title: In vitro activities of daptomycin, ciprofloxacin, and other antimicrobial agents against the cells and spores of clinical isolates of Bacillus species.
abstract: Daptomycin inhibited 67 of 70 clinical isolates of Bacillus species at < or =1 microg/ml and 100% of them at < or =2 microg/ml. It showed bactericidal activity similar to that of ciprofloxacin against vegetative cells but not against spores. For 2 strains, the ciprofloxacin MICs were >4 g/ml, and 10 strains were resistant to erythromycin.
authors.affiliation: Microbial Research Lab, 2G-24, LAC+USC Medical Center, 1801 Marengo Street, Los Angeles, CA 90033, USA. dcitron@usc.edu
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.forename: Maria D
authors.initials: MD
authors.lastname: Appleman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D013171:Spores, Bacterial / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D017576:Daptomycin