title: Malignant nonteratoid ocular medulloepithelioma in a llama (Llama glama).
abstract: A 6-year-old female llama presented with buphthalmos of its right eye owing to the presence of an intraocular mass. The affected globe was enucleated and submitted for microscopic examination. The intraocular mass was diagnosed as malignant medulloepithelioma. Within the following months, the llama developed soft tissue masses, which completely filled the right orbital cavity and expanded the cranial portion of the right mandibular bone, and enlarged mandibular lymph nodes. Euthanasia was elected 30 months after the initial diagnosis. The carcass was submitted for postmortem examination, which revealed the presence of medulloepithelioma metastases within the right orbit, mandible, mandibular lymph nodes, lungs, liver, and mesenteric and sublumbar lymph nodes. The primary intraocular tumor and its metastases were composed of neoplastic undifferentiated neuroepithelial cells, which formed tubules, Flexner-Wintersteiner and Homer Wright rosettes, and rare solid sheets. Electron microscopy showed that tumor cells were connected by desmosome-like junctions and contained rare intracytoplasmic basal bodies. Neoplastic cells were positive for vimentin, nestin, microtubule-associated protein 1B, S-100 protein, and glial fibrillary acidic protein (GFAP). To the best of the authors' knowledge, this is the first report of a malignant nonteratoid ocular medulloepithelioma with distant metastases in a llama and of the ultrastructural and extended immunohistochemical characterization of a nonteratoid medulloepithelioma in this species.
authors.affiliation: Department of Veterinary Pathobiology and Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-1175, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Schoeniger
authors.forename: Ludvik R
authors.initials: LR
authors.lastname: Donner
authors.forename: William G
authors.initials: WG
authors.lastname: Van Alstine
mesh_terms: D000818:Animals; D002161:Camelids, New World / Q000601:surgery*; D015353:Eye Enucleation / Q000662:veterinary; D005134:Eye Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology / Q000601:surgery / Q000662:veterinary*