A new antibacterial carrier of hyaluronic acid gel.
BACKGROUND
Postoperative infection following total joint arthroplasty is thought to be one of the most serious and devastating complications. To develop an effective treatment for this complication, we tested a bioabsorbable antibacterial carrier that is made from novel cross-linked hyaluronic acid (HA) gel and gentamicin (GM).


METHODS
Antibacterial activity of the carrier was evaluated by the agar diffusion test, direct contact test, in vivo mouse model, and in vivo rabbit osteomyelitis model.


RESULTS
GM-containing HA gel suppressed bacterial growth both in vitro and in vivo. In the rabbit osteomyelitis model, beads coated with HA gel containing GM did not disturb bone ongrowth in the femoral stem.


CONCLUSIONS
Our bioabsorbable carrier of antibiotic-containing HA gel is effective for prophylactic treatment or treatment of an actual deep infection following total joint arthroplasty.
Matsuno
Hiroaki
H
Matsuno Clinic for Rheumatic Diseases, Toyama, Japan.
Yudoh
Kazuo
K
Hashimoto
Masamichi
M
Himeda
Yasukazu
Y
Miyoshi
Teruzo
T
Yoshida
Kaoru
K
Kano
Syogo
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D004337:Drug Carriers; D005782:Gels; D005839:Gentamicins / Q000494:pharmacology*; D006622:Hip Prosthesis; D006820:Hyaluronic Acid; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology; D011474:Prosthesis Design; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D005782:Gels; D005839:Gentamicins; D006820:Hyaluronic Acid