title: Recurrent respiratory papillomatosis causing chronic stridor and delayed speech in an 18-month-old boy.
abstract: Recurrent respiratory papillomatosis is a relatively uncommon disease that presents clinically with symptoms ranging from hoarseness to severe dyspnea. Human papilloma virus types 6 and 11 are important in the etiology of papillomas and are most probably transmitted from mother to child during birth. Although spontaneous remission is frequent, pulmonary spread and/or malignant transformation resulting in death has been reported. CO2 laser evaporation of papillomas and adjuvant drug therapy using lymphoblastoid interferon-alpha are the most common treatments. However, several other treatments have been tried, with varying success. In the present report, a case of laryngeal papillomatosis presenting with chronic stridor and delayed speech is described.
authors.affiliation: Department of Pediatrics, Division of Respiratory Medicine, University of Calgary, Calgary, Alberta.
authors.forename: Adel
authors.initials: A
authors.lastname: Alharbi
authors.forename: Derek
authors.initials: D
authors.lastname: Drummond
authors.forename: Alfredo
authors.initials: A
authors.lastname: Pinto
authors.forename: Valerie
authors.initials: V
authors.lastname: Kirk
mesh_terms: D001999:Bronchoscopy; D002908:Chronic Disease; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D007822:Laryngeal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D053685:Laser Therapy; D008297:Male; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D012135:Respiratory Sounds / Q000209:etiology*; D019233:Retreatment; D013064:Speech Disorders / Q000209:etiology*