title: [National external quality assessment in auto-immunity: auto-antibodies against thyroid constituents].
abstract: The French Health Products Safety Agency organized in 2005, for the scheme of the national external quality assessment, a survey on antibodies against thyroid constituents which included for the first time the quantitative assay. The purpose of this survey was to assess the quality of the different methods of these assays. The overall qualitative results are satisfactory. However, this survey pointed out a lower performance for immunodot which appeared to have been misused. Concerning the titer of antibodies, results show a broad dispersion between reagents. This confirms the lack of a real standardisation despite of the existence of the international MRC standards.
authors.affiliation: Agence Française de Sécurité Sanitaire des Produits de Santé (Afssaps), Saint-Denis. Stephanie.ALBAREDE@afssaps.sante.fr
authors.forename: S
authors.initials: S
authors.lastname: Albarède
authors.forename: A
authors.initials: A
authors.lastname: Guyard
authors.forename: E
authors.initials: E
authors.lastname: Burg
authors.forename: B N
authors.initials: BN
authors.lastname: Pham
mesh_terms: D000372:Agglutination Tests; D001323:Autoantibodies / Q000032:analysis*; D015551:Autoimmunity; D005434:Flow Cytometry; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007124:Immunoenzyme Techniques; D007202:Indicators and Reagents; D007753:Laboratories / Q000592:standards*; D049449:Luminescence; D011785:Quality Assurance, Health Care; D011786:Quality Control; D011863:Radioimmunoassay; D011989:Receptors, Thyrotropin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007202:Indicators and Reagents; D011989:Receptors, Thyrotropin