title: Effect of gonadotropin-releasing hormone agonist on a uterine arteriovenous malformation.
abstract: BACKGROUND
  The effect of gonadotropin-releasing hormone agonist (GnRHa) on uterine arteriovenous malformations (AVM) is not well known.
  
  
  METHODS
  A 37-year-old woman with a previous cesarean was diagnosed as having a uterine AVM after a spontaneous abortion with massive vaginal bleeding. The AVM decreased in size from 5.1 x 3.8 cm to 1.4 x 1.0 cm after 6 months of therapy with a GnRHa. Uterine artery embolization conducted after the GnRH therapy resulted in complete disappearance of the AVM. The patient's menstrual cycles and ovulation resumed 3 months after uterine artery embolization.
  
  
  CONCLUSIONS
  Gonadotropin-releasing hormone agonist therapy reduced the size of the uterine AVM. Thus, GnRHa therapy may be useful for uterine AVM in situations where uterine artery embolization must be postponed.
authors.affiliation: Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. mmamoru@med.hokudai.ac.jp
authors.forename: Mamoru
authors.initials: M
authors.lastname: Morikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamada
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
authors.forename: Hisanori
authors.initials: H
authors.lastname: Minakami
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D001165:Arteriovenous Malformations / Q000175:diagnosis* / Q000628:therapy*; D006063:Chorionic Gonadotropin / Q000097:blood; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000628:therapy; D014599:Uterus / Q000098:blood supply*
chemical_list: D006063:Chorionic Gonadotropin; D016729:Leuprolide