Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3.
OBJECTIVE
Genome-wide linkage analyses of schizophrenia have identified several regions that may harbor schizophrenia susceptibility genes, but given the complex etiology of the disorder, it is unlikely that all susceptibility regions have been detected. To address this issue, the authors ascertained 606 Han Chinese families comprising 1,234 affected members.


METHODS
Probands with schizophrenia were recruited from six data collection field research centers in Taiwan. Each proband underwent a diagnostic screen with supplemental medical records and a semistructured interview. Following this screen, the authors administered the Mandarin Chinese version of the Diagnostic Interview for Genetic Studies. Best-estimate final diagnoses were made by two board-certified psychiatrists. The genotyping was conducted by the Center for Inherited Disease Research, with 386 markers spaced at an average of 9-centimorgan (cM) intervals. Empirical simulations were generated to determine genome-wide significance.


RESULTS
The authors found five regions with nonparametric linkage z scores 2.0 or greater. These were the following: 2.08 was reached for D1S551 (113.7) cM at 1p31.1 and 2.31 for D2S410 (125.2 cM) at 2q14.1; 2.00 was reached for D4S2361 (93.5 cM) at 4q21.23, and 2.07 for D15S1012 (36 cM) at 15q14, the largest nonparametric linkage z score was 2.88 for D10S2327 (100.92 cM) at 10q22.3.


CONCLUSIONS
Our 10q22.3 finding at 100.9 cM is consistent with a previously reported nonparametric linkage score of 4.27 at 107.2 cM on chromosome 10, although it did not attain genome-wide significance in this study.
Faraone
Stephen V
SV
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA. faraones@upstate.edu
Hwu
Hai-Gwo
HG
Liu
Chih-Min
CM
Chen
Wei J
WJ
Tsuang
Ming-Ming
MM
Liu
Shih-Kai
SK
Shieh
Ming-Hsien
MH
Hwang
Tzung-Jeng
TJ
Ou-Yang
Wen-Chen
WC
Chen
Chun-Ying
CY
Chen
Chwen-Cheng
CC
Lin
Jin-Jia
JJ
Chou
Frank Huang-Chih
FH
Chueh
Ching-Mo
CM
Liu
Wei-Ming
WM
Hall
Mei-Hua
MH
Su
Jessica
J
Van Eerdewegh
Paul
P
Tsuang
Ming T
MT
D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics* / Q000276:immunology*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D013624:Taiwan / Q000208:ethnology
D005819:Genetic Markers