A putative Ariadne-like ubiquitin ligase is required for Dictyostelium discoideum development.
The Dictyostelium rbrA gene encodes a putative Ariadne ubiquitin ligase. rbrA(-) cells form defective slugs that cannot phototax. Prestalk cell numbers are reduced in rbrA(-) slugs, and these prestalk cells do not localize to the tip of slugs. Chimeric slugs containing wild-type cells could phototax and form fruiting bodies.
Whitney
Nathaniel
N
Department of Biological Sciences, Walla Walla College, 204 S. College Ave., College Place, WA 99324, USA.
Pearson
Lacey J
LJ
Lunsford
Ryan
R
McGill
Lisa
L
Gomer
Richard H
RH
Lindsey
David F
DF
D000595:Amino Acid Sequence; D000818:Animals; D004023:Dictyostelium / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development*; D015870:Gene Expression; D017125:Genes, Protozoan / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013170:Spores / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry / Q000378:metabolism*
D011993:Recombinant Fusion Proteins; D044767:Ubiquitin-Protein Ligases