title: Emergence of multidrug-resistant Klebsiella pneumoniae isolates producing VIM-4 metallo-beta-lactamase, CTX-M-15 extended-spectrum beta-lactamase, and CMY-4 AmpC beta-lactamase in a Tunisian university hospital.
abstract: Klebsiella pneumoniae clinical isolates resistant to carbapenems were recovered from 11 patients in the hospital of Sfax, Tunisia. The isolates were closely related as shown by pulsed-field gel electrophoresis, and they produced VIM-4 metallo-enzyme, CTX-M-15 extended-spectrum beta-lactamase, and CMY-4 AmpC enzyme. The bla(VIM-4) gene is part of a class 1 integron.
authors.affiliation: Laboratoire de Microbiologie, CHU Habib Bourguiba, Sfax, Tunisie.
authors.forename: Sonia
authors.initials: S
authors.lastname: Ktari
authors.forename: Guillaume
authors.initials: G
authors.lastname: Arlet
authors.forename: Basma
authors.initials: B
authors.lastname: Mnif
authors.forename: Valérie
authors.initials: V
authors.lastname: Gautier
authors.forename: Fouzia
authors.initials: F
authors.lastname: Mahjoubi
authors.forename: Mounir
authors.initials: M
authors.lastname: Ben Jmeaa
authors.forename: Mounir
authors.initials: M
authors.lastname: Bouaziz
authors.forename: Adnane
authors.initials: A
authors.lastname: Hammami
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D001483:Base Sequence; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D006785:Hospitals, University; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D014416:Tunisia; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; C473109:beta-lactamase CTX-M-15; C048795:AmpC beta-lactamases; D001618:beta-Lactamases; C482458:metallo-beta-lactamase VIM-4, Klebsiella pneumoniae