title: Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature.
abstract: Metastatic breast cancer involving the hepatobiliary tract or ascites secondary to peritoneal carcinomatosis has been well described. Luminal gastrointestinal tract involvement is less common and recognition of the range of possible presentations is important for early and accurate diagnosis and treatment. We report 6 patients with a variety of presentations of metastatic breast cancer of the luminal gastrointestinal tract. These include oropharyngeal and esophageal involvement presenting as dysphagia with one case of pseudoachalasia, a linitis plastica-like picture with gastric narrowing and thickened folds, small bowel obstruction and multiple strictures mimicking Crohn's disease, and a colonic neoplasm presenting with obstruction. Lobular carcinoma, representing only 10% of breast cancers is more likely to metastasize to the gastrointestinal tract. These patients presented with gastrointestinal manifestations after an average of 9.5 years and as long as 20 years from initial diagnosis of breast cancer. Given the increased survival of breast cancer patients with current therapeutic regimes, more unusual presentations of metastatic disease, including involvement of the gastrointestinal tract can be anticipated.
authors.affiliation: Department of Medicine (Gastroenterology), University of Western Ontario, 529 McGarrell Place, London, Ontario, N6G5L3, Canada. jnazaren@uwo.ca.
authors.forename: Jose
authors.initials: J
authors.lastname: Nazareno
authors.forename: Donald
authors.initials: D
authors.lastname: Taves
authors.forename: Harold-G
authors.initials: HG
authors.lastname: Preiksaitis
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D003680:Deglutition Disorders / Q000209:etiology; D003967:Diarrhea / Q000209:etiology; D004401:Dysarthria / Q000209:etiology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000556:secondary*; D006801:Humans; D008875:Middle Aged; D014839:Vomiting / Q000209:etiology