Anthracyclines-contra cruciform extrusion in DNA regulating sequences.
Despite the existence of a wealth of structural and theoretical data relating to palindromic sequences in the genome, the mechanism of cruciform formation in the presence of anthracyclines in miscellaneous biological processes is still poorly understood. Generally, DNA intercalators influence the DNA superhelicity, which plays a key role in the cruciform formation in DNA molecules. The potential of DNA intercalating ligands on the stabilization/destabilization of cruciform in DNA is discussed. Here, the indirect impact of anthracyclines to cell developing and surviving is analyzed for the first time. Primarily, the anthracycline modifies the helical properties of DNA and the overall DNA structure, and secondarily alters any cruciform-dependent processes, mainly DNA replication and transcription.
Viglasky
Viktor
V
Department of Biochemistry, Institute of Chemistry, Faculty of Sciences, P.J. Safárik University, Kosice, Slovakia. vviglasky@yahoo.com
D000818:Animals; D018943:Anthracyclines / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects* / Q000235:genetics*; D004278:DNA, Superhelical / Q000187:drug effects; D006801:Humans; D007364:Intercalating Agents / Q000494:pharmacology; D009690:Nucleic Acid Conformation; D013696:Temperature
D018943:Anthracyclines; D004278:DNA, Superhelical; D007364:Intercalating Agents; D004247:DNA