Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations.
We have investigated the genetic involvement of the CD4 and the LAG3 genes, two appealing candidates for MS due to their suggested role in MS pathology. We genotyped a Swedish case-control material consisting of 920 MS patients and 778 controls in an initial study of CD4, three SNPs showed a significant association with MS. An independent material consisting of 1720 Nordic MS patients and 1416 controls were used for confirmation of associated markers in CD4 and to do a confirmative study of the LAG3 gene from previous findings. The result, including a total of 2640 MS patients and 2194 controls shows no significant association with CD4 and LAG3 and MS. We conclude that these genes are of minor importance in regard of genetic predisposition to the MS.
Lundmark
Frida
F
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden. frida.lundmark@ki.se
Harbo
Hanne F
HF
Celius
Elisabeth G
EG
Saarela
Janna
J
Datta
Pameli
P
Oturai
Annette
A
Lindgren
Cecilia M
CM
Masterman
Thomas
T
Salter
Hugh
H
Hillert
Jan
J
D000328:Adult; D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D015704:CD4 Antigens / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D009664:Norway / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011237:Predictive Value of Tests; D013548:Sweden / Q000453:epidemiology; D044465:White People / Q000235:genetics; D000093322:Lymphocyte Activation Gene 3 Protein
D015703:Antigens, CD; D015415:Biomarkers; D015704:CD4 Antigens; D005819:Genetic Markers; D000093322:Lymphocyte Activation Gene 3 Protein; C000720326:Lag3 protein, human