TLRs in the Gut. III. Immune responses to flagellin in Crohn's disease: good, bad, or irrelevant?
Recent observations suggest that bacterial flagellin may be a target of the seemingly aberrant innate and adaptive immune responses that are associated with Crohn's disease. This article discusses the evidence that supports a role for flagellin in Crohn's disease and considers the potential roles of these responses in the pathophysiology of this disorder.
Gewirtz
Andrew T
AT
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, GA 30322, USA. agewirt@emory.edu
D000818:Animals; D003424:Crohn Disease / Q000276:immunology* / Q000503:physiopathology; D005408:Flagellin / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D018448:Models, Immunological; D051198:Toll-Like Receptor 5 / Q000502:physiology; D051193:Toll-Like Receptors / Q000502:physiology*
D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; D005408:Flagellin