title: The role of immunostimulation in the development of postweaning multisystemic wasting syndrome in pigs under field conditions.
abstract: We evaluated the effects of immunostimulation in the development of postweaning multisystemic wasting syndrome (PMWS) in 930 pigs 53 to 54 d old in a grower/finisher barn with a history of PMWS. The pigs were allocated to 5 treatment groups: 4 groups received a single intramuscular injection of RespiSure-ONE (a commercial Mycoplasma hyopneumoniae vaccine; n = 197), Emulsigen (an oil-based adjuvant; n = 172), Alhydrogel (an aluminum-hydroxide-based adjuvant; n = 172), or physiologic saline (n = 218); 1 group received no treatment (n = 171). Pigs affected by PMWS were found in all the groups. Antigen to Porcine circovirus type 2 (PCV-2) was detected by immunohistochemical testing within lesions of mesenteric lymph node, spleen, Peyer's patch, and lung of affected pigs. There was no significant difference in the incidence of PMWS among the groups. The findings indicate that immunostimulation did not influence the expression of PMWS in this study. Thus, routine vaccination against swine diseases may not significantly contribute to the occurrence of PMWS under field conditions.
authors.affiliation: Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA. bolyebu@yahoo.com
authors.forename: Julius
authors.initials: J
authors.lastname: Haruna
authors.forename: Paul
authors.initials: P
authors.lastname: Hanna
authors.forename: Daniel
authors.initials: D
authors.lastname: Hurnik
authors.forename: Basil
authors.initials: B
authors.lastname: Ikede
authors.forename: Lisa
authors.initials: L
authors.lastname: Miller
authors.forename: Carmencita
authors.initials: C
authors.lastname: Yason
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000536:Aluminum Hydroxide; D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000032:analysis; D001428:Bacterial Vaccines / Q000494:pharmacology*; D018173:Circoviridae Infections / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D017925:Circovirus; D007150:Immunohistochemistry / Q000662:veterinary; D009175:Mycoplasma Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D014765:Viral Vaccines / Q000494:pharmacology*; D019282:Wasting Syndrome / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
chemical_list: D000276:Adjuvants, Immunologic; D000956:Antigens, Viral; D001428:Bacterial Vaccines; D014765:Viral Vaccines; D000536:Aluminum Hydroxide