title: Toxicological mechanisms of Aconitum alkaloids.
abstract: The toxic effects of Aconitum alkaloids are known to affect mainly the central nervous system, heart and muscle tissues. Their toxicological mechanisms may involve interaction with voltage-dependent Na+ channels, modulation of neurotransmitter release and related receptors, promotion of lipid peroxidation and induction of cell apoptosis in heart, liver or other organs. Of them, the mechanism of interaction with voltage-dependent Na+ channels is quite well known, but the other factors are still unclear, and need to be further studied. This review focuses on the toxicological mechanisms of Aconitum alkaloids.
authors.affiliation: Medicine School and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China.
authors.forename: M
authors.initials: M
authors.lastname: Fu
authors.forename: M
authors.initials: M
authors.lastname: Wu
authors.forename: Y
authors.initials: Y
authors.lastname: Qiao
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
mesh_terms: D031841:Aconitum / Q000633:toxicity*; D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D009498:Neurotoxins / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D011955:Receptors, Drug / Q000187:drug effects; D015222:Sodium Channels / Q000187:drug effects
chemical_list: D000470:Alkaloids; D009498:Neurotoxins; D018377:Neurotransmitter Agents; D011955:Receptors, Drug; D015222:Sodium Channels