title: [Ischemic, an uncommon complication of Biermer disease (pernicious anemia)].
abstract: BACKGROUND
  Stroke in a young adult justifies an extensive etiologic workup.
  
  
  METHODS
  We present a 44-year-old women victim of a frontal ischemic stroke. Extensive evaluation was normal, except for high plasma level of homocysteine in the context of pernicious anemia, otherwise asymptomatic.
  
  
  CONCLUSIONS
  Hyperhomocysteinemia is a known marker, and probably risk factor for stroke, fostering atherosclerosis and thrombosis. It can be found among individuals suffering from homocystinuria, in individuals homozygous for the MHTFR T allele but also when there is deficiency of vitamin B12 or folic acid. Although it is very seldom ascribed, pernicious anemia would be a cause of stroke, possibly though hyperhomocysteinemia.
authors.affiliation: Service de Rééducation, HUG, Switzerland. beatrice.leemann@hcuge.ch
authors.forename: B
authors.initials: B
authors.lastname: Leemann
authors.forename: N
authors.initials: N
authors.lastname: Boughanem
authors.forename: A
authors.initials: A
authors.lastname: Schnider
mesh_terms: D000328:Adult; D000752:Anemia, Pernicious / Q000175:diagnosis*; D001921:Brain / Q000473:pathology; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000175:diagnosis; D007511:Ischemia / Q000209:etiology*; D008279:Magnetic Resonance Imaging
chemical_list: D006710:Homocysteine