title: Estrogenic activity of furanocoumarins isolated from Angelica dahurica.
abstract: In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 microg/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.
authors.affiliation: School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
authors.forename: Xiang Lan
authors.initials: XL
authors.lastname: Piao
authors.forename: Hye Hyun
authors.initials: HH
authors.lastname: Yoo
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Tak Lim
authors.initials: TL
authors.lastname: Kang
authors.forename: Gwi Seo
authors.initials: GS
authors.lastname: Hwang
authors.forename: Jeong Hill
authors.initials: JH
authors.lastname: Park
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis; D029969:Angelica / Q000737:chemistry*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004790:Enzyme Induction / Q000187:drug effects; D011564:Furocoumarins / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D048789:Phytoestrogens / Q000302:isolation & purification* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011564:Furocoumarins; D048789:Phytoestrogens; D010936:Plant Extracts; D011960:Receptors, Estrogen; D000469:Alkaline Phosphatase