title: [Lipid lowering goals in high risk and very high cardiovascular risk patients: a reasonable challenge?].
abstract: OBJECTIVE
  The last modifications of the National Cholesterol Education Program (NCEP) indicate some lower therapeutic targets of low density protein cholesterol (LDL-c) in patients with very high vascular risk. Our study aims to establish the degree of compliance of the therapeutic targets defined by these modifications.
  
  
  METHODS
  Descriptive and cross sectional study of patients from a cardiovascular clinic. Low-density lipoprotein cholesterol (LDL-c) was calculated and targets were established according the new update of NCEP-ATP III.
  
  
  RESULTS
  836 patients, 625 (75%) with HR and 211(25%) with VHR were studied 45% of HR and 67% of VHR were receiving treatment with statins (p < 0.001) but only 38% of HR and 15% of VHR achieved target LDL-c levels. The percentage of patients who could achieve LDL-goals using the maximum approved dose of the statins plus other lipid lowering drug was calculated: The 31% of HR and 51% of VHR were unable to achieve the LDL-c targets.
  
  
  CONCLUSIONS
  Only 15% of very high risk patients achieve target levels of LDL-c according to the new NCEP-ATP III recommendations. Even using maximum dose of statins in combination with other lipid lowering drugs, less than half of the patients will be able to achieve LDL-c goal (< 70 mg/dl).
authors.affiliation: Unidades de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Valencia. España.
authors.forename: A
authors.initials: A
authors.lastname: Gómez-Belda
authors.forename: E
authors.initials: E
authors.lastname: Rodilla
authors.forename: C
authors.initials: C
authors.lastname: González
authors.forename: J A
authors.initials: JA
authors.lastname: Costa
authors.forename: B
authors.initials: B
authors.lastname: Serra
authors.forename: J M
authors.initials: JM
authors.lastname: Pascual
mesh_terms: D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D003430:Cross-Sectional Studies; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents