title: G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke.
abstract: The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC+CC versus GG, p=0.48). The C allele was not significantly different between the patients and controls (C versus G, p=0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.
authors.affiliation: Department of Neurology, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan. hidehatt@1999.jukuin.keio.ac.jp
authors.forename: Hidenori
authors.initials: H
authors.lastname: Hattori
authors.forename: Akira
authors.initials: A
authors.lastname: Sonoda
authors.forename: Hideki
authors.initials: H
authors.lastname: Sato
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ito
authors.forename: Norio
authors.initials: N
authors.lastname: Tanahashi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Murata
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saito
authors.forename: Kiyoaki
authors.initials: K
authors.lastname: Watanabe
authors.forename: Norihiro
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D002545:Brain Ischemia / Q000235:genetics*; D006801:Humans; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051127:Scavenger Receptors, Class E / Q000235:genetics*; D020521:Stroke / Q000235:genetics*
chemical_list: C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E