Use of a modified-live vaccine to prevent persistent testicular infection with bovine viral diarrhea virus.
A commercial vaccine containing modified-live bovine viral diarrhea virus (BVDV; types 1 and 2) was administered to one group of 22 peripubertal bulls 28 days before intranasal inoculation with a type 1 strain of BVDV. A second group of 23 peripubertal bulls did not receive the modified-live BVDV vaccine before intranasal inoculation. Ten of 23 unvaccinated bulls--but none of the vaccinated bulls--developed a persistent testicular infection as determined by immunohistochemistry and polymerase chain reaction. Results of this study indicate that administration of a modified-live vaccine containing BVDV can prevent persistent testicular infection if peripubertal bulls are vaccinated before viral exposure.
Givens
M Daniel
MD
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Riddell
Kay P
KP
Zhang
Yijing
Y
Galik
Patricia K
PK
Stringfellow
David A
DA
Brodersen
Bruce W
BW
Jackson
James A
JA
Ellsworth
Michael A
MA
Ficken
Martin D
MD
Carson
Robert L
RL
Wenzel
James G W
JG
Marley
M Shonda
MS
D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D002417:Cattle; D030241:Diarrhea Virus 1, Bovine Viral / Q000276:immunology* / Q000302:isolation & purification; D030242:Diarrhea Virus 2, Bovine Viral / Q000276:immunology* / Q000302:isolation & purification; D018562:Disease Transmission, Infectious / Q000517:prevention & control / Q000662:veterinary*; D007150:Immunohistochemistry / Q000379:methods / Q000662:veterinary; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods / Q000662:veterinary; D011897:Random Allocation; D012661:Semen / Q000821:virology; D013733:Testicular Diseases / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D013737:Testis / Q000821:virology; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D017201:Virus Shedding
D014613:Vaccines, Attenuated; D014765:Viral Vaccines