title: Levetiracetam versus placebo in childhood and adolescent autism: a double-blind placebo-controlled study.
abstract: The purpose of this study was to determine the safety and efficacy of the anticonvulsant levetiracetam in the treatment of children with autism. A previous open-label study in autistic children treated with levetiracetam demonstrated effectiveness in hyperactivity, impulsivity/aggression, and mood lability. Twenty patients with autism ranging from 5 to 17 years of age were entered into a 10-week, placebo-controlled, double-blind trial of levetiracetam versus placebo. The mean maximum dosage for levetiracetam was 862.50+/-279.19 mg/day. We evaluated global improvement of autism with the Clinical Global Impression-Improvement (CGI-I) Scale and aggression and affective instability with the Aberrant Behavior Checklist (ABC) parent and teacher ratings. We measured repetitive behaviors using the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) score and impulsivity and hyperactivity with the Conners' Rating Scale-Revised: Long Version for parent and teacher. No significant difference was found between levetiracetam and placebo groups comparing the change in CGI-I (t=0.350, d.f.=13.621, P=0.765), nor on change in ABC, CY-BOCS or Conners' scales. These findings suggest that levetiracetam does not improve behavioral disturbances of autism, but are limited by the small sample size and lack of stratification of the autistic sample at baseline.
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. stacey.wasserman@mssm.edu
authors.forename: Stacey
authors.initials: S
authors.lastname: Wasserman
authors.forename: Rupa
authors.initials: R
authors.lastname: Iyengar
authors.forename: William F
authors.initials: WF
authors.lastname: Chaplin
authors.forename: Dryden
authors.initials: D
authors.lastname: Watner
authors.forename: Shulamit E
authors.initials: SE
authors.lastname: Waldoks
authors.forename: Evdokia
authors.initials: E
authors.lastname: Anagnostou
authors.forename: Latha
authors.initials: L
authors.lastname: Soorya
authors.forename: Eric
authors.initials: E
authors.lastname: Hollander
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D001321:Autistic Disorder / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002652:Child Behavior / Q000523:psychology; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D010919:Placebos; D000077287:Levetiracetam; D010889:Piracetam