title: [Chemical modification of heparin].
abstract: Heparin was modified at carboxyl groups by reaction with several pharmacologically important amino-containing compounds in aqueous medium in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide. In dependence on the nature of the amine and the ratio of reagents, conjugates containing 36-100% amide and 0-25% isoureidocarbonyl groups were synthesized. Isoureidoarylamide groups are present, along with amide moieties, in the products of heparin modification by hydroxyl-containing aromatic amines. The conjugate of heparin with p-aminobenzoic acid contained oligomeric arylamide.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Ponedel'kina
authors.forename: V N
authors.initials: VN
authors.lastname: Odinokova
authors.forename: E S
authors.initials: ES
authors.lastname: Lukina
authors.forename: T V
authors.initials: TV
authors.lastname: Tiumkina
authors.forename: L M
authors.initials: LM
authors.lastname: Khalilov
authors.forename: U M
authors.initials: UM
authors.lastname: Dzhemilev
mesh_terms: D000588:Amines / Q000737:chemistry; D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D005022:Ethyldimethylaminopropyl Carbodiimide / Q000031:analogs & derivatives / Q000737:chemistry; D006493:Heparin / Q000031:analogs & derivatives* / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000588:Amines; D020533:Angiogenesis Inhibitors; D012996:Solutions; D014867:Water; C041829:1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide methiodide; D006493:Heparin; D005022:Ethyldimethylaminopropyl Carbodiimide