title: Orally disintegrating olanzapine for the treatment of a manic patient with esophageal stricture plus chronic pharyngitis.
abstract: An orally disintegrating tablet formulation of olanzapine (ODT olanzapine) is designed to dissolve rapidly upon contact with saliva. We describe a manic patient who has an esophageal stricture and chronic pharyngitis, two conditions that impede the swallowing of medications. She was successfully treated for her mania with this orally disintegrating formulation. This case report shows that ODT olanzapine may be useful in the psychiatric management of manic and other patients for whom olanzapine is appropriate, and who have an underlying medical condition that impedes swallowing oral medications.
authors.affiliation: Department of Psychiatry, Tzu-Chi General Hospital, Hualien City, Taiwan, ROC. shengmp@so-net.net.tw
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Shen
authors.forename: Mei-Ying
authors.initials: MY
authors.lastname: Lee
authors.forename: Chaucer C H
authors.initials: CC
authors.lastname: Lin
authors.forename: Chia-Hsiang
authors.initials: CH
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001569:Benzodiazepines / Q000008:administration & dosage; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy*; D002908:Chronic Disease; D004940:Esophageal Stenosis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077152:Olanzapine; D010612:Pharyngitis / Q000150:complications / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine