Angiotensins II and IV modulate adrenocortical cell proliferation in ovariectomized rats.
Effects of angiotensins II (AngII), angiotensin IV (AngIV, 3-8 fragment of angiotensin II) and losartan (an antagonist of angiotensin receptor type 1) on the proliferation of adrenocortical cells in ovariectomized rats have been studied. The incorporation of bromodeoxyuridine (BrdU) into cell nuclei was used as an index of cell proliferation. AngIV decreased BrdU labeling index mainly in the reticularis zone and losartan (Los) was able to partially reverse this inhibitory effect of AngIV. AngII had no effect on the adrenocortical cell proliferation when given alone, however Los given simultaneously diminished BrdU incorporation into nuclei of glomerulosa and reticularis zones as compared with AngII. These findings suggest that AngII and AngIV modulate adrenocortical cell proliferation in ovariectomized rats.
Siejka
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A
Department of Clinical Endocrinology, Chair of Endocrinology, Medical University of Lodz, Lodz, Poland.
Mełeń-Mucha
G
G
Mucha
S A
SA
Pawlikowski
M
M
D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000502:physiology*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D001973:Bromodeoxyuridine / Q000032:analysis; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D006651:Histocytochemistry; D019808:Losartan / Q000494:pharmacology; D023421:Models, Animal; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar
D047228:Angiotensin II Type 1 Receptor Blockers; D000804:Angiotensin II; C012877:angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-; D001973:Bromodeoxyuridine; D019808:Losartan