title: Scleritis complicating zoledronic acid infusion.
abstract: We present a case of severe unilateral posterior scleritis associated with zoledronic acid administration that was recognized and treated in a timely manner. Subsequent use of pamidronate was associated with milder inflammation in the same eye that eventually resolved with continued monthly infusions, indicating the possibility of immunologic tolerance. Physicians prescribing these drugs should be aware of this side effect, which, if not recognized and treated appropriately, is potentially devastating. We review the published data as well as the current treatment recommendations.
authors.affiliation: Department of Ophthalmology, University of Maryland, Baltimore, MD 21201, USA.
authors.forename: David
authors.initials: D
authors.lastname: Benderson
authors.forename: Joyson
authors.initials: J
authors.lastname: Karakunnel
authors.forename: Sajeev
authors.initials: S
authors.lastname: Kathuria
authors.forename: Ashraf
authors.initials: A
authors.lastname: Badros
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004164:Diphosphonates / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D000077268:Pamidronate; D011859:Radiography; D015423:Scleritis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000077211:Zoledronic Acid
chemical_list: D000893:Anti-Inflammatory Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D000077268:Pamidronate