title: Consequences of living-donor liver transplantation for upper gastrointestinal lesions: high incidence of reflux esophagitis.
abstract: There is little information available regarding the consequences of living-donor liver transplantation (LDLT) for upper gastrointestinal lesions. We retrospectively compared the pre- and posttransplant incidences of noninfectious reflux esophagitis, portal hypertensive gastropathy (PHG), esophageal varix, gastroduodenal ulcer, Helicobacter pylori infection, and abnormal gastroesophageal valve in 29 adult patients (16 males, 13 females) who underwent LDLT for end-stage liver disease. Here we present four findings from this study. First, the posttransplant incidence of noninfectious esophagitis was significantly higher than the pretransplant incidence (27.6% vs. 3.4%; P < 0.001), irrespective of postoperative use of standard-dose H2RA. Second, PHG and esophageal varix, which were noted in 65.5% and 96.6% of pretransplant recipients, respectively, spontaneously resolved postoperatively in all cases. Third, H. pylori infection, which was observed in 50.0% of preoperative recipients, decreased to 5.6% postoperatively, although no significant difference was observed between the pre- and the posttransplant incidences of gastroduodenal ulcer (6.9% vs. 6.9%). Finally, the incidence of abnormal gastroesophageal valve did not change following LDLT (34.5% vs. 34.5%). In conclusion, this study suggests that noninfectious reflux esophagitis occurs more frequently following LDLT. Although the disease is the results of a very complex interaction of various factors, spontaneous resolution of PHG and serendipitous H. pylori eradication might have contributed to increased incidence of postoperative esophagitis, possibly through gastric acid hypersecretion. In contrast, morphological change of the gastroesophageal valve was not considered to be the cause of this disease. Because this study was a retrospective analysis of a small population of LDLT recipients, prospective randomized controlled studies of a sufficient number of cases are required to substantiate these conclusions.
authors.affiliation: Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Akatsu
authors.forename: Masashi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawachi
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanabe
authors.forename: Motohide
authors.initials: M
authors.lastname: Shimazu
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kumai
authors.forename: Masaki
authors.initials: M
authors.lastname: Kitajima
mesh_terms: D000328:Adult; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices / Q000453:epidemiology; D004942:Esophagitis, Peptic / Q000453:epidemiology*; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications; D016031:Liver Transplantation / Q000379:methods; D019520:Living Donors; D008875:Middle Aged; D010437:Peptic Ulcer / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology*