title: An evaluation of the metaphylactic effect of ceftiofur crystalline free Acid in feedlot calves.
abstract: The relative effect of metaphylactic ceftiofur crystalline free acid (CCFA) versus metaphylactic tilmicosin was evaluated in beef calves under commercial feedlot conditions in Nebraska. At feedlot arrival, 11,605 animals at ultrahigh risk of developing bovine respiratory disease (BRD) were allocated to one of three experimental groups: CCFA-3 (6.6 mg/kg SC), CCFA-7 (6.6 mg/kg), or TILM-3 (tilmicosin, 10 mg/kg SC). Animals were eligible for subsequent BRD treatment 3 (CCFA-3 and TILM-3 groups) or 7 (CCFA-7 group) days later. Compared with the TILM-3 group, overall chronicity, overall mortality, BRD mortality, and metabolic mortality rates were significantly (P < .05) lower in the CCFA-3 and CCFA-7 groups; average daily gain was significantly (P < .05) higher in the CCFA-3 group; the proportion of quality grade No Roll carcasses was significantly (P < .05) lower in the CCFA-3 and CCFA-7 groups; and there were per-animal advantages of 22.05 dollars and 18.98 dollars in the CCFA-3 and CCFA-7 groups, respectively. In beef calves at ultrahigh risk of developing BRD, it is more cost effective to administer metaphylactic CCFA than tilmicosin at feedlot arrival.
authors.affiliation: Feedlot Health Management Services, PO Box 140, Bay 7, 87 Elizabeth Street, Okotoks, Alberta, Canada, T1S 2A2.
authors.forename: Calvin W
authors.initials: CW
authors.lastname: Booker
authors.forename: Oliver C
authors.initials: OC
authors.lastname: Schunicht
authors.forename: P Timothy
authors.initials: PT
authors.lastname: Guichon
authors.forename: G Kee
authors.initials: GK
authors.lastname: Jim
authors.forename: Brian K
authors.initials: BK
authors.lastname: Wildman
authors.forename: Tom J
authors.initials: TJ
authors.lastname: Pittman
authors.forename: Tye
authors.initials: T
authors.lastname: Perrett
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D048090:Bovine Respiratory Disease Complex / Q000188:drug therapy* / Q000517:prevention & control*; D002417:Cattle; D002511:Cephalosporins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007279:Injections, Subcutaneous / Q000662:veterinary; D018942:Macrolides / Q000494:pharmacology; D008297:Male; D011897:Random Allocation; D012307:Risk Factors; D016896:Treatment Outcome; D015645:Tylosin / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D018942:Macrolides; C053503:ceftiofur; C052319:tilmicosin; D015645:Tylosin