title: A short water-soluble self-assembling peptide forms amyloid-like fibrils.
abstract: A water-soluble tripeptide Val-Ile-Ala (VIA) , bearing sequence identity with the C-terminal portion of the Alzheimer Abeta-peptide (Abeta(40-42)), self-assembles, in crystalline form, to produce an intermolecularly hydrogen bonded supramolecular beta-sheet structure which self-associates to form straight, unbranched nanofibrils exhibiting amyloid-like behavior; in contrast, the synthetic tripeptide Ala-Val-Ile (AVI) self-assembles to produce a beta-sheet structure that forms branched nanofibrils which do not show any characteristic features of amyloid-like fibrils.
authors.affiliation: Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India.
authors.forename: Sudipta
authors.initials: S
authors.lastname: Ray
authors.forename: Apurba K
authors.initials: AK
authors.lastname: Das
authors.forename: Michael G B
authors.initials: MG
authors.lastname: Drew
authors.forename: Arindam
authors.initials: A
authors.lastname: Banerjee