title: Reduction of Cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells.
abstract: Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosides (RGUG). In our previous studies, this new processed ginseng reduced cisplatin-induced nephrotoxicity more than white ginseng in both in vitro and in vivo systems. In this study, we isolated and characterized active principles through activity-guided fractionation. Ginsenosides Rh4 and Rk3 significantly reduced the cisplatin-induced nephrotoxicity in LLC-PK1 cells in a dose-dependent manner. The mechanisms of function and structure-activity relationships with other ginsenosides remain for further investigation.
authors.affiliation: Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University, Seoul, Korea.
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Baek
authors.forename: Xiang Lan
authors.initials: XL
authors.lastname: Piao
authors.forename: Un Jo
authors.initials: UJ
authors.lastname: Lee
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Jeong Hill
authors.initials: JH
authors.lastname: Park
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology; D002945:Cisplatin / Q000633:toxicity*; D019610:Cytoprotection; D004305:Dose-Response Relationship, Drug; D036145:Ginsenosides / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D018374:LLC-PK1 Cells; D005894:Panax / Q000737:chemistry*; D013552:Swine
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D036145:Ginsenosides; D002945:Cisplatin