title: Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in Northeastern Brazil.
abstract: A disease of the central nervous system in goats was observed in the municipalities of Juazeiro, Casa Nova and Curaça, state of Bahia, and Petrolina, state of Pernambuco, Northeastern Brazil. The disease was produced experimentally in two goats by the administration of dry Turbina cordata mixed with grain. Clinical signs were observed after the ingestion of 62 and 106 g/kg body weight in 28 and 54 days, respectively. The concentration of swainsonine in the plant varied from less than 0.001% to 0.14% (dry weight). Clinical signs of natural and experimental cases included difficulties in standing, ataxia, hypermetria, wide-based stance, intention tremors, spastic paresis mainly in the hind legs, nystagmus, abnormal postural reactions, head tilting, and falling. Diffuse vacuolation of neurons, epithelial cells of pancreas, thyroids, and renal tubules were observed on the histology. From the electron microscopy of Purkinje cells the vacuoles represented dilated lysosomes. These findings demonstrated that T. cordata causes an acquired glycoprotein lysosomal storage disease. The intoxication occurs at least in an area of 27,000 km2 causing severe losses in goats, and some farmers report the disease also in cattle.
authors.affiliation: Hospital Veterinário, CSTR, UFCG, Campus de Patos, Patos-PB 58700-000, Brazil.
authors.forename: A F M
authors.initials: AF
authors.lastname: Dantas
authors.forename: F
authors.initials: F
authors.lastname: Riet-Correa
authors.forename: D R
authors.initials: DR
authors.lastname: Gardner
authors.forename: R M T
authors.initials: RM
authors.lastname: Medeiros
authors.forename: S S
authors.initials: SS
authors.lastname: Barros
authors.forename: B L
authors.initials: BL
authors.lastname: Anjos
authors.forename: R B
authors.initials: RB
authors.lastname: Lucena
mesh_terms: D000818:Animals; D001938:Brazil / Q000453:epidemiology; D002531:Cerebellum / Q000473:pathology; D027722:Convolvulaceae / Q000506:poisoning*; D015511:Goat Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D006041:Goats; D016464:Lysosomal Storage Diseases / Q000453:epidemiology / Q000662:veterinary*; D008297:Male; D010939:Plant Poisoning / Q000453:epidemiology / Q000662:veterinary*; D012621:Seasons; D017026:Swainsonine / Q000506:poisoning
chemical_list: D017026:Swainsonine