[The evaluation of the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelial cells of patients with cystic fibrosis].
OBJECTIVE
To investigate the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelialcells of patients with cystic fibrosis.


METHODS
15 patients with cystic fibrosis and 15 control subjects were included in this study. Impression cytology specimens were collected and analyzed by flow cytometry and analyzed by flow cytometry.


RESULTS
A significant increase of ICAM-1 expression by epithelial cells was found in patients with cystic fibrosis compared with normal eyes.


CONCLUSIONS
Increase of ICAM-1 expression by epithelial cells in cystic fibrosis patients suggests, that the inflammation appears to have a role in the pathogenesis of the ocular surface changes and may be a marker of the inflammatory status in cystic fibrosis.
Mrugacz
Małgorzata
M
Kliniki Okulistyki Dzieciecej, Akademii Medycznej w Białymstoku.
Zak
Janusz
J
Bakunowicz-Lazarczyk
Alina
A
Wysocka
Jolanta
J
Minarowska
Alina
A
Radomski
Karol
K
D000293:Adolescent; D000328:Adult; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002648:Child; D003228:Conjunctiva / Q000378:metabolism*; D003231:Conjunctivitis / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000378:metabolism* / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000378:metabolism*; D008297:Male; D012016:Reference Values
D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1