Cellular pattern formation during retinal regeneration: a role for homotypic control of cell fate acquisition.
A dominant mechanism of cellular patterning in the growing fish retina is control of cell fate acquisition by negative feedback signals arising from differentiated cells. We tested the ability of a computational model of this pattern formation mechanism to simulate cellular patterns in regenerated goldfish retina. The model successfully simulated quantitative features of in vivo regenerated patterns, indicating that regenerating retina has access to and utilizes patterning mechanisms that are operational during normal growth. The atypical patterns of regenerated retina could arise in part from regenerative progenitors that, compared to normal growth progenitors, are less responsive to the feedback patterning signals.
Tyler
Melinda J
MJ
Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210, USA.
Cameron
David A
DA
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology; D006054:Goldfish / Q000502:physiology*; D008959:Models, Neurological; D009416:Nerve Regeneration; D012160:Retina / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology