title: Self-sustained pH oscillations in a compartmentalized enzyme reactor system.
abstract: This work represents our continued effort toward fulfilling the need to discover a model system for experimental investigations of temporal oscillations in an enzyme-membrane system. In this paper, the regions in the parameter space where self-sustained pH oscillations can be induced for a compartmentalized enzyme reactor system, which consists of a well-stirred reactor, a reservoir and a membrane containing no enzyme, were determined via numerical simulation with two proteolytic enzymes: papain (EC 3.4.22.2) and alpha-chymotrypsin (EC 3.4.21.1). The sizes of the regions were qualitatively compared with those associated with enzymic membrane system. As a result, we found that the possibility of experimentally observing self-sustained oscillations in the compartmentalized papain reactor system, as well as in the papain-membrane system, is high. However, self-sustained pH oscillations are less likely in the compartmentalized alpha-chymotrypsin reactor system than in the alpha-chymotrypsin-membrane system.
authors.affiliation: National Institute of Materials and Chemical Research, 1-1 Higashi, Tsukuba 305, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohmori
authors.forename: M
authors.initials: M
authors.lastname: Nakaiwa
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Kawamura
authors.forename: R Y
authors.initials: RY
authors.lastname: Yang