title: The histone deubiquitinating enzyme Ubp10 is involved in rDNA locus control in Saccharomyces cerevisiae by affecting Sir2p association.
abstract: Histone modifications influence chromatin structure and thus regulate the accessibility of DNA to replication, recombination, repair, and transcription. We show here that the histone deubiquitinating enzyme Ubp10 contributes to the formation/maintenance of silenced chromatin at the rDNA by affecting Sir2p association.
authors.affiliation: Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, 20126 Milano, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Calzari
authors.forename: Ivan
authors.initials: I
authors.lastname: Orlandi
authors.forename: Lilia
authors.initials: L
authors.lastname: Alberghina
authors.forename: Marina
authors.initials: M
authors.lastname: Vai
mesh_terms: D000107:Acetylation; D004275:DNA, Ribosomal / Q000235:genetics* / Q000378:metabolism; D020868:Gene Silencing; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D047468:Immunoprecipitation; D008745:Methylation; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D056565:Sirtuin 2; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000378:metabolism; D043222:Ubiquitin Thiolesterase
chemical_list: D004275:DNA, Ribosomal; D006657:Histones; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D025801:Ubiquitin; C403282:UBP10 protein, S cerevisiae; D043222:Ubiquitin Thiolesterase; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases