Selected players in the inflammation cascade and drugs that target these inflammation genes against metastasis.
Despite many recent advances the prognosis of cancer patients with metastasis still remains poor. In metastatic invasion, tumor cells interact with endothelial cells through several distinct adhesion molecules. Adherent tumor cells extravasate into tissues by degrading basement membranes with matrix degrading enzymes such as heparanases and matrix metalloproteinases. Endothelial expression of matrix degrading enzymes and adhesion molecules are under the control of inflammatory cytokines. These inflammatory proteins and the signaling pathways involved in the expression of these genes are under intense investigation as therapeutic targets to prevent tumor growth and metastasis. The current review focuses on selected players of the inflammation cascade and drugs that target these inflammatory genes.
Alikunju
Shanavas
S
Discovery Research, Dr. Reddy's Laboratories, Miyapus, Hyderabad, India.
Pillarisetti
Sivaram
S
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016207:Cytokines / Q000502:physiology; D005966:Glucuronidase / Q000037:antagonists & inhibitors; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology; D061965:Matrix Metalloproteinase Inhibitors; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D009362:Neoplasm Metastasis / Q000503:physiopathology* / Q000517:prevention & control; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013792:Thalidomide / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000502:physiology; D051879:Twist-Related Protein 1 / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology; D000099175:Heparanase
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D005966:Glucuronidase; D061965:Matrix Metalloproteinase Inhibitors; D020928:Mitogen-Activated Protein Kinases; D016328:NF-kappa B; D013792:Thalidomide; D014409:Tumor Necrosis Factor-alpha; D051879:Twist-Related Protein 1; D048051:p38 Mitogen-Activated Protein Kinases; D000099175:Heparanase