Induction of apoptosis in lymphoid and myeloid leukemia.
Defects in the core machinery of the apoptosis pathway contribute to chemoresistance and poor outcomes in patients with acute leukemia. To overcome these defects, novel molecules that target key proteins in the apoptosis pathway are being developed. This review highlights compounds that target the mitochondrial, death receptor, and convergence pathways of caspase activation that are being developed for the treatment of acute leukemia.
Schimmer
Aaron D
AD
Princess Margaret Hospital, Room 9-516, 610 University Avenue, Toronto, ON, M5G 2M9, Canada. aaron.schimmer@utoronto.ca
D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D020169:Caspases / Q000378:metabolism; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000378:metabolism / Q000628:therapy*; D008928:Mitochondria / Q000502:physiology; D008954:Models, Biological; D053218:Receptors, Death Domain / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; D053218:Receptors, Death Domain; D020169:Caspases