Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa.
We assessed neutralizing antibody titers to adenovirus serotype 5 (Ad5) and six rare adenovirus serotypes, serotypes 11, 35, 50, 26, 48, and 49, in pediatric populations in sub-Saharan Africa. We observed a clear age dependence of Ad5-specific neutralizing antibody titers. These data will help to guide the development of Ad vector-based vaccines for human immunodeficiency virus type 1 and other pathogens.
Thorner
Anna R
AR
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Research East, Room 213, 330 Brookline Avenue, Boston, MA 02215, USA.
Vogels
Ronald
R
Kaspers
Jorn
J
Weverling
Gerrit J
GJ
Holterman
Lennart
L
Lemckert
Angelique A C
AA
Dilraj
Athmanundh
A
McNally
Lisa M
LM
Jeena
Prakash M
PM
Jepsen
Soren
S
Abbink
Peter
P
Nanda
Anjali
A
Swanson
Patricia E
PE
Bates
Andrew T
AT
O'Brien
Kara L
KL
Havenga
Menzo J E
MJ
Goudsmit
Jaap
J
Barouch
Dan H
DH
D000258:Adenovirus Infections, Human / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D000260:Adenoviruses, Human / Q000276:immunology*; D000293:Adolescent; D017954:Africa South of the Sahara / Q000453:epidemiology; D000375:Aging; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral