Toll-like receptor 4: link to the anti-inflammatory effects of exercise?
Evidence is emerging that exercise training has anti-inflammatory effects. Our early finding that blood cultures from trained subject had a reduced responsiveness to lipopolysaccharide led to a series of studies in which we measured toll-like receptor 4--the primary signaling receptor for lipopolysaccharide. The toll-like receptor 4 expression was consistently lower in physically active subjects compared with inactive subjects and reduced after training in previously inactive subjects.
Flynn
Michael G
MG
Wastl Human Performance Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, IN 47907, USA. mickflyn@purdue.edu
McFarlin
Brian K
BK
D016207:Cytokines / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000534:rehabilitation; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
D016207:Cytokines; D051197:Toll-Like Receptor 4