title: Molecular characterisation of pneumococcal serotype 16F: Established predominant carriage and otitis media serotype in the 7vPCV era.
abstract: Young Australian Aboriginal children in remote communities experience very high rates of pneumococcal carriage and otitis media. Prior to introduction of the 7-valent pneumococcal conjugate vaccine (7vPCV, Prevenar), serotype 16F was an important type found in nasal and ear discharge swabs. Since commencement of pneumococcal immunisation for Aboriginal infants in 2001, 16F has become the predominant established serotype in carriage and otitis media in young Aboriginal children. BOX typing and multi-locus sequence typing revealed a diverse population of serotype 16F strains, and evidence of potential capsule switching from a vaccine serotype 4 to a serotype 16F.
authors.affiliation: Menzies School of Health Research, Darwin, Northern Territory, Australia. robyn.marsh@menzies.edu.au
authors.forename: R L
authors.initials: RL
authors.lastname: Marsh
authors.forename: H
authors.initials: H
authors.lastname: Smith-Vaughan
authors.forename: J
authors.initials: J
authors.lastname: Beissbarth
authors.forename: K
authors.initials: K
authors.lastname: Hare
authors.forename: M
authors.initials: M
authors.lastname: Kennedy
authors.forename: C
authors.initials: C
authors.lastname: Wigger
authors.forename: G
authors.initials: G
authors.lastname: Mellon
authors.forename: E
authors.initials: E
authors.lastname: Stubbs
authors.forename: J R
authors.initials: JR
authors.lastname: Gadil
authors.forename: A
authors.initials: A
authors.lastname: Pettit
authors.forename: G
authors.initials: G
authors.lastname: Mackenzie
authors.forename: P
authors.initials: P
authors.lastname: Tipakalippa
authors.forename: P S
authors.initials: PS
authors.lastname: Morris
authors.forename: A J
authors.initials: AJ
authors.lastname: Leach
mesh_terms: D001315:Australia; D016667:Bacterial Capsules; D002648:Child; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D022401:Meningococcal Vaccines / Q000627:therapeutic use*; D010033:Otitis Media / Q000382:microbiology* / Q000517:prevention & control*; D011008:Pneumococcal Infections / Q000382:microbiology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000302:isolation & purification
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines