[Genetic polymorphism of HLA-Cw locus in hematopoietic stem cell transplantation patient and donor population].
OBJECTIVE
To analyze the distribution of genes in HLA-Cw locus from Han population of China in a large scale, and to provide basic data for further study on the genetic characteristics of HLA-Cw locus of this population.


METHODS
Totally 1285 unrelated Chinese Han individuals were typed by PCR-SSP, and statistics was utilized to investigate the distribution rules of detected genes.


RESULTS
Twenty-three HLA-Cw alleles were identified in Chinese Han population, out of them HLA-Cw*01, *03, *07 and *08 were the commonest genes, which accounted for frequencies of 0.1529, 0.2385, 0.1747 and 0.1004, respectively. Five genes which could not be identified by serological method were deaed: HLA-Cw*12, *14, *15, *16 and *17. Hardy-Weinberg test showed that the observed genetic polymorphism distribution values were correspondent with the expected (chi-square=73.74, df=98, P>0.5).


CONCLUSIONS
This study may serve a full-scale scientific genetic parameters of HLA-Cw genes for Chinese Han population studies.
Liu
Jin-feng
JF
Department of Immunology, Affiliated Hospital of AMMS, Laboratory of Immunoassay of NCBA, Beijing,100039 PR China.
Sun
Yu-ying
YY
Jin
Li
L
Liang
Fei
F
Liu
Nan
N
Yuan
Fang
F
Luo
Yuan
Y
Liu
Shu-guang
SG
Song
Xin-qiang
XQ
Xi
Yong-zhi
YZ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D015236:HLA-C Antigens / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D014019:Tissue Donors; D055815:Young Adult
D015236:HLA-C Antigens