[Cytochrom-P450 mediated drug interactions caused by antibiotics].
This review focuses on drug interactions with commonly prescribed antibiotics. With each drug coadministered, the likelihood of an adverse interaction increases exponentially. Thus, poly-pharmacotherapy possesses important clinical challenges for clinicians and exposes patients to potentially life-threatening risks. In particular, following co-administration of drugs such as tricyclic antidepressants, anticoagulants and antiarrhythmics, which are characterized by narrow therapeutic windows, even small changes in plasma levels can cause serious adverse reactions and/or therapeutic failure. The hepatic and intestinal cytochrome, or CYP-450 enzyme system is responsible for the biotransformation of a multitude of drugs and is frequently involved in drug interactions. The present review therefore presents a comprehensive overview on potential drug interactions with antibiotics, which are mediated by the cytochrome-P450-enzymes.
Thallinger
Christiane
C
Universitätsklinik für Klinische Pharmakologie, Universitätsklinik für Innere Medizin I, Medizinische Universität Wien, Wien, Austria.
Joukhadar
Christian
C
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001711:Biotransformation / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004789:Enzyme Activation / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D012307:Risk Factors
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System