title: Maternal androgen and estrogen concentrations are not associated with blood pressure changes in uncomplicated pregnancies.
abstract: Systolic blood pressure increase between the second and third trimester of pregnancy has been associated with a substantially reduced maternal breast cancer risk, and it has been suggested that elevated androgens mediate the association. Androgen and estrogen concentrations were measured in maternal serum collected in 86 uncomplicated, singleton pregnancies. Overall, there were no consistent or statistically significant patterns of association between the hormones and systolic, diastolic, or mean arterial blood pressure or blood pressure change between trimesters. Results were similar with adjustment for factors related to the hormones. These data are not consistent with the hypothesis that elevated androgen concentrations mediate the observed reduction in maternal breast cancer risk associated with increases in blood pressure over the pregnancy.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892-7246, USA. troisir@mail.nih.gov
authors.forename: Rebecca
authors.initials: R
authors.lastname: Troisi
authors.forename: Lars
authors.initials: L
authors.lastname: Vatten
authors.forename: Robert N
authors.initials: RN
authors.lastname: Hoover
authors.forename: James M
authors.initials: JM
authors.lastname: Roberts
authors.forename: Bernard F
authors.initials: BF
authors.lastname: Cole
authors.forename: Nancy
authors.initials: N
authors.lastname: Potischman
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D016022:Case-Control Studies; D004967:Estrogens / Q000097:blood*; D005260:Female; D006801:Humans; D010298:Parity; D010414:Pennsylvania; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology; D011247:Pregnancy / Q000097:blood*; D011264:Pregnancy Trimesters / Q000097:blood; D012016:Reference Values
chemical_list: D000728:Androgens; D015415:Biomarkers; D004967:Estrogens