title: Oral squamous cell carcinoma around dental implants.
abstract: It is well documented that oral squamous cell carcinoma (OSCC) is related to risk factors such as smoking and alcohol consumption as well as premalignant lesions and conditions such as leukoplakia, oral lichen planus (OLP), and previous malignancy of the upper respiratory system and gastrointestinal tract. Osseointegrated dental implants are rarely reported in association with OSCC. This article presents 2 cases of OSCC adjacent to dental implants in patients at risk for oral cancer--1 was a heavy smoker with OLP; the other had a history of previous oral and colon cancer. Six additional cases of malignancy adjacent to dental implants were retrieved from the literature; the majority of cases had at least 1 recognized risk factor for oral cancer. Although such cases are rarely reported, patients at risk for oral cancer, especially those with multiple existing risk factors, that present with failing dental implants should be thoroughly evaluated to rule out the presence of malignancy disguised as peri-implant disease.
authors.affiliation: Oral Diseases Clinic, Department of Oral Medicine, Hadassah School of Dental Medicine, The Hebrew University, Jerusalem, Israel. rakefetc@hadassah.org.il
authors.forename: Rakefet
authors.initials: R
authors.lastname: Czerninski
authors.forename: Ilana
authors.initials: I
authors.lastname: Kaplan
authors.forename: Galit
authors.initials: G
authors.lastname: Almoznino
authors.forename: Alexander
authors.initials: A
authors.lastname: Maly
authors.forename: Eran
authors.initials: E
authors.lastname: Regev
mesh_terms: D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000175:diagnosis*; D003110:Colonic Neoplasms / Q000150:complications; D015921:Dental Implants / Q000009:adverse effects*; D019232:Dental Restoration Failure; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D005887:Gingival Neoplasms / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D017676:Lichen Planus, Oral / Q000150:complications; D008297:Male; D008339:Mandibular Neoplasms / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D019226:Oral Ulcer / Q000150:complications; D010518:Periodontitis / Q000175:diagnosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D015921:Dental Implants