title: [Propofol infusion syndrome].
abstract: The propofol infusion syndrome is a rare but potentially lethal complication resulting from a prolonged continuous administration of propofol. It was first described in the beginning of the 1990's and in recent years there have been frequent reports of problems in association with the use of propofol sedation. The cardinal signs and symptoms of the propofol infusion syndrome are metabolic acidosis, rhabdomyolysis, renal failure, cardiac arrhythmias and a progressive, often therapy-resistant cardiac failure. The pathophysiology of this syndrome appears to involve a disturbance of mitochondrial metabolism induced by propofol. Our report involves a case of propofol infusion syndrome in a patient having undergone cardiac surgery.
authors.affiliation: Abt. für Anästhesie und Allgemeine Intensivmedizin, Landeskrankenhaus, St. Veiter Strasse 47, 9020 Klagenfurt, Austria. ernst.trampitsch@lkh-klu.at
authors.forename: E
authors.initials: E
authors.lastname: Trampitsch
authors.forename: M
authors.initials: M
authors.lastname: Oher
authors.forename: I
authors.initials: I
authors.lastname: Pointner
authors.forename: R
authors.initials: R
authors.lastname: Likar
authors.forename: R
authors.initials: R
authors.lastname: Jost
authors.forename: H V
authors.initials: HV
authors.lastname: Schalk
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000175:diagnosis; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000368:Aged; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis; D001026:Coronary Artery Bypass; D004452:Echocardiography; D006801:Humans; D007262:Infusions, Intravenous; D007431:Intraoperative Complications / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D011188:Potassium / Q000097:blood; D015742:Propofol / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis; D013577:Syndrome
chemical_list: D018686:Anesthetics, Intravenous; D011188:Potassium; D015742:Propofol