Isolated hepatic involvement of cat scratch disease in immunocompetent adults: Enhanced magnetic resonance imaging, pathological findings, and molecular analysis--two cases.
Visceral involvement in absence of lymphadenopathy is a rare manifestation in cat scratch disease; hepatic granulomas are rare, representing 0.3% of systemic manifestations of cat scratch disease, and gallbladder extension is a singular case. The present article refers to 2 rare cases of visceral cat scratch disease in immunocompetent adults with hepatic granulomatous inflammation, caused by Bartonella henselae infection, with gallbladder involvement in 1 case and no lymphadenopathy. Histological features demonstrated the presence of inflammatory necrotizing granulomatous nonneoplastic process. Molecular studies (polymerase chain reaction) were performed to confirm the infectious etiology.
Marsilia
Giuseppina Marino
GM
Department of Pathology, Cardarelli Hospital, Naples, Italy. gmarinomars@tiscali.it
La Mura
Anna
A
Galdiero
Roberta
R
Galdiero
Emilia
E
Aloj
Giovanni
G
Ragozzino
Alfonso
A
D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000235:genetics / Q000378:metabolism; D018416:Bartonella henselae / Q000235:genetics / Q000472:pathogenicity*; D002372:Cat-Scratch Disease / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007121:Immunocompetence; D008099:Liver / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D000097382:CD68 Molecule
D015703:Antigens, CD; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; D004269:DNA, Bacterial; C067980:CD68 antigen, human; D000097382:CD68 Molecule