title: Isolated IgG3 deficiency in children: to treat or not to treat? Case presentation and review of the literature.
abstract: Immunoglobulin G3 (IgG3) subclass deficiency has received rather little attention thus far. In this report, the clinical and immunologic characteristics of six children with isolated IgG3 deficiency are discussed. The currently available literature on IgG3 deficiency is reviewed with specific emphasis on the peculiarities of the IgG3 subclass, the clinical relevance of IgG3 deficiency as well as the therapeutic options.
authors.affiliation: Department of Pediatrics, University Hospital Leuven, Herestraat 49, Leuven, Belgium. isabelle.meyts@med.kuleuven.ac.be
authors.forename: Isabelle
authors.initials: I
authors.lastname: Meyts
authors.forename: X
authors.initials: X
authors.lastname: Bossuyt
authors.forename: M
authors.initials: M
authors.lastname: Proesmans
authors.forename: Boeck
authors.initials: B
authors.lastname: De
mesh_terms: D000907:Antibodies, Bacterial / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000097:blood / Q000188:drug therapy / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D018655:Lymphocyte Count; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D011110:Polymorphism, Genetic; D011135:Polysaccharides, Bacterial / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D016756:Immunoglobulins, Intravenous; D037601:Mannose-Binding Lectin; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial