title: e19a2 BCR-ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases.
abstract: This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR-ABL fusion transcript e19a2. This finding suggests that CML carrying mu-BCR breakpoint may exhibit a clinical course similar to typical CML.
authors.affiliation: Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, Kolkata, India.
authors.forename: B C
authors.initials: BC
authors.lastname: Mondal
authors.forename: S
authors.initials: S
authors.lastname: Majumdar
authors.forename: U B
authors.initials: UB
authors.lastname: Dasgupta
authors.forename: U
authors.initials: U
authors.lastname: Chaudhuri
authors.forename: P
authors.initials: P
authors.lastname: Chakrabarti
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharyya
mesh_terms: D000328:Adult; D018450:Disease Progression; D017809:Fatal Outcome; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D014158:Transcription, Genetic
chemical_list: D016044:Fusion Proteins, bcr-abl