title: A structural-energetic basis for B-cell epitope prediction.
abstract: Structural-energetic analysis of peptide and protein antigens in the context of binding to antibody reveals fundamental differences between the cross-reactions of antipeptide antibody with protein and antiprotein antibody with peptide, providing a physicochemical basis for B-cell epitope prediction as applied to the development of peptide-based vaccines and immunodiagnostics.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, 547 Pedro Gil Street, Ermita, Manila 1000, Philippines. badong@cm.upm.edu.ph
authors.forename: Salvador Eugenio C
authors.initials: SE
authors.lastname: Caoili
mesh_terms: D000465:Algorithms; D000818:Animals; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D013816:Thermodynamics
chemical_list: D018985:Epitopes, B-Lymphocyte