title: The role of magnesium as an adjuvant during general anaesthesia.
abstract: Magnesium sulphate is used extensively in the treatment of eclampsia, and is also used to treat refractory arrhythmias, asthma, myocardial ischaemia and acute respiratory failure. We studied the interaction between magnesium sulphate and the anaesthetic agents propofol, rocuronium bromide and fentanyl citrate. This randomised, double blind study was conducted in 50 patients. The magnesium group A (n = 25) received 30 mg x kg(-1) magnesium sulphate before induction of anaesthesia and 10 mg x kg(-1) continuously intra-operatively until the end of surgery. Group B (n = 25) received the same volume of isotonic saline. Propofol, rocuronium and fentanyl infusions were started and the patients lungs' were ventilated with 33% oxygen in nitrous oxide. Anaesthetic depth was maintained at a bispectral index value of between 40 and 60. Muscle relaxation was maintained at a train-of-four count of 1 throughout surgery using neuromuscular monitoring. The fentanyl infusion was titrated to haemodynamic variables: heart rate and blood pressure. We concluded that magnesium sulphate has anaesthetic, analgesic and muscle relaxation effects and significantly reduces the drug requirements of propofol, rocuronium and fentanyl during anaesthesia.
authors.affiliation: Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi, India.
authors.forename: K
authors.initials: K
authors.lastname: Gupta
authors.forename: V
authors.initials: V
authors.lastname: Vohra
authors.forename: J
authors.initials: J
authors.lastname: Sood
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000328:Adult; D000732:Androstanols; D000768:Anesthesia, General / Q000379:methods*; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents; D015742:Propofol; D000077123:Rocuronium; D013997:Time Factors
chemical_list: D000759:Adjuvants, Anesthesia; D000732:Androstanols; D018686:Anesthetics, Intravenous; D003473:Neuromuscular Nondepolarizing Agents; D008278:Magnesium Sulfate; D005283:Fentanyl; D000077123:Rocuronium; D015742:Propofol