[Toxic epidermal necrolysis].
Toxic epidermal necrolysis is the prototype of a proapoptotic disease characterized by system CD95 dysrregulation. Drugs constitute the main antigenic triggers. Hystopatologically it is characterized by epidermis detachment and necrosis with apoptotic keratinocytes. Clinical presentation includes erithematous-ampullous lesions in the skin and mucous membranes. It is associated with serious complications such as severe sepsis and septic shock. The management in the intensive care unit includes support treatment and specific treatment with immunoglobulins that alter disease course. Recombinant activated Factor VII is effective to control the associated microvascular haemorraghe.
Carrillo-Esper
Raúl
R
Servicio de Terapia Intensiva, Hospital Central Sur de Alta especialidad de PEMEX, México DF, México. seconcapcma@mail.medinet.net.mx
Elizondo-Argueta
Sandra
S
Sánchez-Zúñiga
Martín de Jesús
Mde J
Visoso-Palacios
Porfirio
P
Cedillo-Torres
Héctor
H
Carrillo-Córdova
Jorge Raúl
JR
D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000628:therapy*