The proline-rich domain and the microtubule binding domain of protein tau acting as RNA binding domains.
Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.
Wang
XingSheng
X
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Rd, Chaoyang District, Beijing 100101, China.
Wang
DongLiang
D
Zhao
Jing
J
Qu
MeiHua
M
Zhou
XiaoHong
X
He
HaiJin
H
He
RongQiao
R
D045744:Cell Line, Tumor; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D011392:Proline / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012313:RNA / Q000378:metabolism*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism*
D016875:tau Proteins; D012313:RNA; D011392:Proline