title: Long-term survival in patients with acute leukemia and chronic disseminated candidiasis despite minimal antileukemic therapy.
abstract: Infections may require discontinuation of antineoplastic chemotherapy, which, in turn, renders patients vulnerable to disease progression or relapse. We identified six patients with acute leukemia in whom antineoplastic treatment had to be discontinued because of chronic disseminated candidiasis (CDC). However, despite minimal antileukemic treatment, all patients remained in complete remission. Immunologic mechanisms associated with CDC might have had an antileukemic effect.
authors.forename: Meinholf
authors.initials: M
authors.lastname: Karthaus
authors.forename: Holger
authors.initials: H
authors.lastname: Hebart
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.forename: Hansjoerg
authors.initials: H
authors.lastname: Schaefer
authors.forename: Hans
authors.initials: H
authors.lastname: Scheel-Walter
authors.forename: Dieter
authors.initials: D
authors.lastname: Buchheidt
authors.forename: Thomas
authors.initials: T
authors.lastname: Lehrnbecher
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002177:Candidiasis / Q000188:drug therapy* / Q000453:epidemiology; D002675:Child, Preschool; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017741:Survivors
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents