title: Prognostic significance of atrial fibrillation in thrombolysed and non thrombolysed patients.
abstract: OBJECTIVE
  Atrial fibrillation (AF) is considered a frequent complication of acute myocardial infarction (AMI). The aim of this study was to examine the incidence and prognostic significance of AF complicating AMI.
  
  
  METHODS
  A total of 848 patients with AMI were examined evaluating: age, sex, coronary risk factors, incidence of AF, prior ischemic events, infarct location, electrocardiogram on admission, thrombolytic therapy, in-hospital complications and mortality.
  
  
  RESULTS
  AF was recorded in 84 patients (9.9%). They were older (P<0.0001), less frequently smokers (P<0.007), had higher creatinekinase level (P<0.005) and more advanced heart failure (Killip class >or=2). AF was documented in non-thrombolysed more than in thrombolysed patients (11.2% vs 7.5%). Overall mortality resulted significantly higher in patients with AF (P=0.001); nevertheless it did not result as independent predictor of mortality. Instead, independent predictors of mortality have been Killip class >or= II (P<0.0001), age (P<0.0001) and prior infarction (P<0.002 ).
  
  
  CONCLUSIONS
  In our experience, AF cannot be considered an independent predictor of mortality. Contrary, advanced heart failure, either in thrombolysed or not-thrombolysed patients, is an independent predictor of AF and mortality. Nevertheless, AF represents an expression of advanced heart failure, that is worsened by the development of arrhythmia with severe consequences on prognosis.
authors.affiliation: Department of Clinical Sciences, Umberto I Polyclinic,La Sapienza University, Rome, Italy. massimo.trappolini@uniroma1.it
authors.forename: M
authors.initials: M
authors.lastname: Trappolini
authors.forename: A
authors.initials: A
authors.lastname: Scorza
authors.forename: F M
authors.initials: FM
authors.lastname: Chillotti
authors.forename: F
authors.initials: F
authors.lastname: Trappolini
authors.forename: A
authors.initials: A
authors.lastname: Danese
authors.forename: F
authors.initials: F
authors.lastname: De Vito
authors.forename: E
authors.initials: E
authors.lastname: Luberti
authors.forename: L
authors.initials: L
authors.lastname: Angrisani
authors.forename: S
authors.initials: S
authors.lastname: Braucci
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy*; D011379:Prognosis; D015912:Thrombolytic Therapy