New developments in the use of tricyclic antidepressants for the management of pain.
In recent years, tricyclic antidepressant drugs have experienced a resurgence in their use as valuable pharmacological tools in the treatment of pain. Along with the evolution in our understanding of their analgesic mechanisms of action, there have been concurrent breakthroughs regarding their indications for use and modes of administration. This review focuses on recent advances in our understanding of how antidepressant drugs exert their antinociceptive effects, and new developments regarding their clinical application.
Cohen
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SP
Walter Reed Army Medical Center, Pain Management Center, Washington, District of Columbia 20307, USA. steven_cohen@hotmail.com
Abdi
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