title: Magnetic resonance spectroscopy detects brain injury and predicts cognitive functioning in children with brain injuries.
abstract: Proton magnetic resonance spectroscopy (1H-MRS) and neuropsychological assessment were utilized in a longitudinal investigation of traumatic brain injury (TBI) in children. A spectroscopic imaging protocol was implemented, and neurometabolite ratios of NAA/Cre and Cho/Cre were calculated for anterior and posterior halves of a supraventricular slab of brain tissue. NAA/Cre was reduced and Cho/Cre increased in TBI patients as compared to controls, for both brain regions. Each ratio predicted aspects of neuropsychological performance, though the specific relationships varied somewhat by region and function. Anterior NAA/Cre increased and anterior Cho/Cre decreased from 3 to 21 weeks post-injury, suggesting neurometabolic recovery.
authors.affiliation: Department of Psychology, University of New Mexico, Albuquerque, New Mexico 87131, USA. ryeo@unm.edu
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Yeo
authors.forename: John P
authors.initials: JP
authors.lastname: Phillips
authors.forename: Rex E
authors.initials: RE
authors.lastname: Jung
authors.forename: April J
authors.initials: AJ
authors.lastname: Brown
authors.forename: Richard C
authors.initials: RC
authors.lastname: Campbell
authors.forename: William M
authors.initials: WM
authors.lastname: Brooks
mesh_terms: D000293:Adolescent; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology*; D016022:Case-Control Studies; D002648:Child; D002794:Choline / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008568:Memory / Q000502:physiology; D009043:Motor Activity / Q000502:physiology
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline