Effect of diclofenac on prevention of posterior capsule opacification in human eyes.
BACKGROUND
Diclofenac sodium has been demonstrated to be effective in preventing proliferation of lens epithelial cells both in vitro and in animal studies. The effects of diclofenac sodium given during the hydrodissection stage of phacoemulsification surgery on posterior capsule opacification (PCO) were investigated.


METHODS
Eleven patients undergoing phacoemulsification in both eyes were included. Patients with pseudoexfoliation, uveitis, and diabetes were excluded. Hydrodissection was done with only balanced salt solution in the first eyes. In the fellow eyes, 0.25 mg/mL diclofenac was given with hydrodissection. The same type of intraocular lens was implanted in both eyes of each patient. Follow-up was 21.8 (SD 3.5) months in the diclofenac group and 22.9 (3.7) months in the control group. PCO was evaluated clinically by dividing the posterior capsule into 24 zones. Mann-Whitney U test was used for statistical analysis.


RESULTS
There were no statistically significant differences of age, diameter of capsulorhexis, pupillary width, visual acuity, intraocular pressure, or length of follow-up between groups. PCO score was 0.49 (SD 0.21) in eyes receiving diclofenac and 0.73 (0.23) in the contralateral fellow eyes. The difference was not statistically significant (p=0.053).


CONCLUSIONS
Diclofenac sodium given by hydrodissection in phacoemulsification decreased, but did not significantly prevent, the development of PCO.
Inan
Umit Ubeyt
UU
Department of Ophthalmology, Kocatepe University School of Medicine, Afyonkarahisar, and the Beyoğlu Research and Teaching Eye Hospital, Istanbul, Turkey.
Bozkurt
Ercüment
E
Oztürk
Faruk
F
Ermis
Samet
S
Yaman
Sevim
S
D000368:Aged; D002386:Cataract / Q000517:prevention & control*; D049109:Cell Proliferation / Q000187:drug effects*; D004008:Diclofenac / Q000008:administration & dosage*; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007430:Intraoperative Care; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D008297:Male; D018918:Phacoemulsification; D011183:Postoperative Complications / Q000517:prevention & control*
D005938:Glucocorticoids; D004008:Diclofenac