title: Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression.
abstract: Squamous cell carcinoma antigen (SCCA) is a useful tumor marker for diagnosis and management of squamous cell carcinoma. Recent studies have shown that SCCA can influence the behavior of cancer cells. It is well known that cell-cell adhesion is an important factor for the progression of cancer. The present study, therefore, was undertaken to investigate the effect of SCCA2 on the cell adhesion related molecule, E-cadherin, and cancer cell behavior. For this purpose, antisense SCCA2 cDNA was transfected into human uterine cancer cell lines, SKG IIIa and SiHa, which express SCCA2. Suppression of SCCA2 expression by antisense SCCA2 cDNA transfection decreased E-cadherin expression and promoted cell migration and invasion as well as the blockage of E-cadherin function by anti-E-cadherin antibody administration. In conclusion, SCCA2 regulates cell migration and invasion via E-cadherin expression, suggesting that SCCA2 may be involved in cancer behavior such as invasion or metastasis.
authors.affiliation: Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Murakami
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kaneko
authors.forename: Shugo
authors.initials: S
authors.lastname: Nawata
authors.forename: Osamu
authors.initials: O
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kato
authors.forename: Norihiro
authors.initials: N
authors.lastname: Sugino
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics / Q000502:physiology*; D015820:Cadherins / Q000037:antagonists & inhibitors*; D002448:Cell Adhesion / Q000187:drug effects / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects / Q000235:genetics; D016373:DNA, Antisense / Q000494:pharmacology; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics*; D015843:Serpins / Q000235:genetics / Q000502:physiology*
chemical_list: D000951:Antigens, Neoplasm; D015820:Cadherins; D016373:DNA, Antisense; D015843:Serpins; C051072:squamous cell carcinoma-related antigen