title: Murine experimental autoimmune gastritis models refractive to development of intrinsic factor autoantibodies, cobalamin deficiency and pernicious anemia.
abstract: Researchers have developed murine lymphopenic, non-lymphopenic, transgenic, spontaneous and infectious agent based models to induce an experimental autoimmune gastritis (EAG) for the study of human organ-specific autoimmune disease. These models result in a chronic inflammatory mononuclear cell infiltrate in the gastric mucosa, destruction of parietal and zymogenic cells with autoantibodies reactive to the gastric parietal cells and the gastric H+/K+ ATPase (ATP4), arguably hallmarks of a human autoimmune gastritis (AIG). In the case of AIG, it is well documented that, in addition to parietal cell antibodies being detected in up to 90% of patients, up to 70% have intrinsic factor antibodies with the later antibodies considered highly specific to patients with pernicious anemia. This is the first report specifically investigating the occurrence of intrinsic factor antibodies, cobalamin deficiency and pernicious anemia in EAG models. We conclude, in contrast to AIG, that, in the three EAG models examined, intrinsic factor is not selected as a critical autoantigen.
authors.affiliation: Department of Medicine, Monash University Central and Eastern Clinical School, Alfred Medical Research and Education Precinct (AMREP), Commercial Road Prahran, Victoria, 3181, Australia. deanneg@unimelb.edu.au
authors.forename: Deanne L V
authors.initials: DL
authors.lastname: Greenwood
authors.forename: John W
authors.initials: JW
authors.lastname: Sentry
mesh_terms: D000752:Anemia, Pernicious / Q000209:etiology*; D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005756:Gastritis; D017506:H(+)-K(+)-Exchanging ATPase / Q000276:immunology; D015151:Immunoblotting; D007437:Intrinsic Factor / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007437:Intrinsic Factor; D017506:H(+)-K(+)-Exchanging ATPase; D014805:Vitamin B 12