Induced transgenerational genetic effects in rodents and humans.
Delayed appearance of induced mutations has been observed in Drosophila, plants, rodents and recently in humans. The significance of this phenomenon is now recognized especially after the pioneering work of Nomura demonstrating transgenerational tumour induction in mice following treatment with urethane or ionizing radiation. A brief review of the literature on transgenerational genetic effects, namely, chromosomal aberrations and mutations, in rodents and humans is presented here.
Natarajan
A T
AT
Department of Toxicogenetics, Leiden University Medical Centre, Leiden, The Netherlands. natarajan@lumc.nl
D000818:Animals; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009154:Mutation; D016273:Occupational Exposure; D011247:Pregnancy; D011832:Radiation Injuries / Q000235:genetics; D011833:Radiation Injuries, Experimental / Q000235:genetics; D018788:Radioactive Hazard Release