title: Catalytic asymmetric reductive amination of aldehydes via dynamic kinetic resolution.
abstract: A novel organocatalytic asymmetric reductive amination of aldehydes has been developed. Treating racemic alpha-branched aldehydes with p-anisidine and a Hantzsch ester in the presence of our previously developed phosphoric acid catalyst, TRIP, gave beta-branched secondary amines in excellent yields and enantioselectivities via an efficient dynamic kinetic resolution. The process is applicable to several different aromatic aldehydes and amines but gives slightly reduced enantiomeric ratios with aliphatic aldehydes.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Hoffmann
authors.forename: Marcello
authors.initials: M
authors.lastname: Nicoletti
authors.forename: Benjamin
authors.initials: B
authors.lastname: List