title: Ambulatory 24-h oesophageal impedance-pH recordings: reliability of automatic analysis for gastro-oesophageal reflux assessment.
abstract: Oesophageal pH-impedance monitoring allows detection of acid and non-acid gastro-oesophageal reflux (GOR) events. Visual analysis of impedance recording requires expertise. Our aim was to evaluate the efficacy of an automated analysis for GOR assessment. Seventy-three patients with suspected GORD underwent 24-h oesophageal pH-impedance monitoring. Recordings analysis was performed visually (V) and automatically using Autoscan function (AS) of Bioview software. A symptom index (SI) > or =50% was considered for a significant association between symptoms and reflux events. AS analysis detected more reflux events, especially non-acid, liquid, pure gas and proximal events. Detection of oesophageal acid exposure and acid reflux events was similar with both analyses. Agreement between V and AS analysis was good (Kendall's coefficient W > 0.750, P < 0.01) for all parameters. During pH-impedance studies, 65 patients reported symptoms. As compared to visual analysis, the sensitivity and specificity of a positive SI determined by AS were respectively 85.7% and 80% for all reflux events, 100% and 98% for acid reflux and 33% and 87.5% for non-acid reflux. Despite good agreement with visual analysis, automatic analysis overestimates the number of non-acid reflux events. Visual analysis remains the gold standard to detect an association between symptoms and non-acid reflux events.
authors.affiliation: Department of Digestive Physiology, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. sabine.roman@chu-lyon.fr
authors.forename: S
authors.initials: S
authors.lastname: Roman
authors.forename: S
authors.initials: S
authors.lastname: Bruley des Varannes
authors.forename: P
authors.initials: P
authors.lastname: Pouderoux
authors.forename: U
authors.initials: U
authors.lastname: Chaput
authors.forename: F
authors.initials: F
authors.lastname: Mion
authors.forename: J-P
authors.initials: JP
authors.lastname: Galmiche
authors.forename: F
authors.initials: F
authors.lastname: Zerbib
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001331:Automation; D050782:Esophageal pH Monitoring; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D012680:Sensitivity and Specificity; D012984:Software