title: Lipophilicity parameters for ionic liquid cations and their correlation to in vitro cytotoxicity.
abstract: Regarding the great structural variability of the currently expanding group of ionic liquids, it is highly desirable to understand the basic factors affecting their toxicity in different biological systems. The present study of a set of 74 ionic liquids with imidazolium, pyrrolidinium, pyridinium, quinolinium, quaternary phosphonium and quaternary ammonium cations and the comparatively small anions Cl(-), Br(-), BF(4)(-), or PF(6)(-) demonstrates the influence of the cation lipophilicity on the cytotoxicity in IPC-81 leukemia cells from rats. The scope of this correlation is limited to ionic liquids with these or similarly small anions that are sufficiently nonreactive under physiological and chromatographic conditions and whose cation lipophilicity does not exceed a certain threshold.
authors.affiliation: Department of Bioorganic Chemistry, UFT Center of Environmental Science and Technology, University of Bremen, Leobener Strasse, D-28359 Bremen, Germany. jranke@uni-bremen.de
authors.forename: Johannes
authors.initials: J
authors.lastname: Ranke
authors.forename: Anja
authors.initials: A
authors.lastname: Müller
authors.forename: Ulrike
authors.initials: U
authors.lastname: Bottin-Weber
authors.forename: Frauke
authors.initials: F
authors.lastname: Stock
authors.forename: Stefan
authors.initials: S
authors.lastname: Stolte
authors.forename: Jürgen
authors.initials: J
authors.lastname: Arning
authors.forename: Reinhold
authors.initials: R
authors.lastname: Störmann
authors.forename: Bernd
authors.initials: B
authors.lastname: Jastorff
mesh_terms: D000818:Animals; D000838:Anions / Q000737:chemistry / Q000633:toxicity; D002412:Cations / Q000737:chemistry / Q000633:toxicity*; D049109:Cell Proliferation / Q000187:drug effects*; D057927:Hydrophobic and Hydrophilic Interactions; D052578:Ionic Liquids / Q000737:chemistry / Q000633:toxicity*; D007928:Lethal Dose 50; D007938:Leukemia / Q000473:pathology; D051381:Rats; D018570:Risk Assessment; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000838:Anions; D002412:Cations; D052578:Ionic Liquids; D014874:Water Pollutants, Chemical