Lack of estrogenic or antiestrogenic actions of soy isoflavones in an avian model: the Japanese quail.
Isoflavones are soy compounds that possess weak estrogenic and antiestrogenic activities. In addition, phytochemicals, including isoflavones, may play a role in regulating seasonal reproductive cycles. As soy is a common constituent in poultry diets, the effect of these compounds on the reproductive system of production birds may be of concern. The present study examined the putative effects of soy isoflavones supplemented into the diet at 1 and 5% using endpoints of growth and reproduction in the Japanese quail. Isoflavones did not exert an effect on growth, feed intake, growth:feed, or the weight of the estrogen-sensitive immature oviduct in female quail. Furthermore, isoflavones did not influence the growth of the oviduct stimulated by exogenous estradiol. Similarly, isoflavones did not influence growth, feed intake, or growth:feed in male quail. However, isoflavones at 1%, but not 5%, in the diet reduced photoperiod-induced testis development 40% vs. control. In contrast, isoflavones did not influence testis regression stimulated by exogenous estradiol in sexually maturing male quail. The present results suggest that isoflavones may exert modest endocrine disruptor-like effects on reproduction in male, but not female, quail.
Wilhelms
K W
KW
Interdepartmental Toxicology Program, Iowa State University, Ames 50011, USA.
Scanes
C G
CG
Anderson
L L
LL
D000821:Animal Feed; D000818:Animals; D003370:Coturnix / Q000254:growth & development*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D010057:Oviducts / Q000187:drug effects / Q000254:growth & development; D017440:Photoperiod; D048789:Phytoestrogens / Q000008:administration & dosage / Q000494:pharmacology*; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D012737:Sex Factors; D012741:Sexual Maturation / Q000187:drug effects / Q000502:physiology; D013737:Testis / Q000187:drug effects* / Q000254:growth & development; D015430:Weight Gain / Q000187:drug effects
D007529:Isoflavones; D048789:Phytoestrogens