title: Transition from molecular chaos to coherent spiking of enzymic reactions in small spatial volumes.
abstract: Theoretical study of an irreversible enzymic reaction with allosteric product activation reveals that, in small spatial volumes, it can undergo a transition to coherent spiking regime characterized by the presence of strong correlations between reaction events and the states of individual enzyme molecules.
authors.affiliation: Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Hess
authors.forename: A
authors.initials: A
authors.lastname: Mikhailov