[Disturbances in aggregability of red blood cells in essential hypertension].
The study was performed to find the relationship between rheological properties of erythrocytes and the effectiveness of antihypertensive therapy both in patients suffering from essential hypertension as well as in spontaneously hypertensive rats (SHR). Additionally, in patients receiving the same antihypertensive therapy we evaluated the effect of aspirin at a low and high dose on aggregation of erythrocytes. We found that in a consequence of uniformed antihypertensive therapy which in patients lasted minimum one year and consisted of one of ACE inhibitors (enalapril or perindopril or captopril), one of beta-antagonists (metoprolol or bisoprolol) and diuretic agent (indapamid), while SHR lasted 8 days and consisted of ACE inhibitor (chinapril), blood pressure lowered and red blood cell rheology was significantly improved. For the first time we observed that antihypertensive treatment which advantageously decreased the aggregability of erythrocytes was diminished by a high dose of aspirin (300 mg/day).
Korbut
Renata A
RA
Katedra Farmakologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków. mfkorbut@cyf-kr.edu.pl
Adamek-Guzik
Teresa
T
D000328:Adult; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects; D001794:Blood Pressure / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D000959:Antihypertensive Agents; D001241:Aspirin