title: Severe vocal cord dysfunction resistant to all current therapeutic interventions.
abstract: Vocal cord dysfunction (VCD) is characterised by paradoxical vocal cord adduction during inspiration or throughout the respiratory cycle, it results in wheeze, stridor, cough and dyspnoea. Although asthma and VCD can coexist, patients with VCD are frequently misdiagnosed with refractory asthma. It can severely restrict an individual's level of activity and effective therapeutic control can be difficult to achieve. We report the case of a patient who was treated with all available therapeutic interventions, including intralaryngeal botulinum toxin injection, but failure resulted in a permanent trachesotomy.
authors.affiliation: North West Lung Centre, Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT, UK. drgoldstein05@yahoo.co.uk
authors.forename: R
authors.initials: R
authors.lastname: Goldstein
authors.forename: J
authors.initials: J
authors.lastname: Bright
authors.forename: S M
authors.initials: SM
authors.lastname: Jones
authors.forename: R M
authors.initials: RM
authors.lastname: Niven
mesh_terms: D000328:Adult; D018726:Anti-Dyskinesia Agents / Q000008:administration & dosage; D001249:Asthma / Q000150:complications / Q000188:drug therapy; D001905:Botulinum Toxins / Q000008:administration & dosage; D006801:Humans; D007267:Injections; D007818:Laryngeal Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D012138:Respiratory Therapy / Q000379:methods; D013070:Speech Therapy / Q000379:methods; D014139:Tracheostomy / Q000379:methods; D017211:Treatment Failure; D014827:Vocal Cords / Q000503:physiopathology*
chemical_list: D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins