Enantioselective beta-lactone formation from ketene and aldehydes catalyzed by a chiral oxazaborolidine.
[reaction: see text] A novel catalytic system has been developed for the enantioselective synthesis of beta-lactones from ketene and aldehydes.
Gnanadesikan
Vijay
V
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Corey
E J
EJ
D000447:Aldehydes / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D005030:Ethylenes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D001372:Aza Compounds; D001896:Boron Compounds; D005030:Ethylenes; D007659:Ketones; D007783:Lactones; C008223:ketene