Serum and urine concentrations of trypsinogen-activation peptide as markers for acute pancreatitis in cats.
The purpose of this study was to compare the clinical utility of the serum concentration of feline trypsin-like immunoreactivity (fTLI), the plasma and urine concentrations of trypsinogen-activation peptide (TAP), and the ratio of the urine TAP and creatinine concentrations (TAP:Cr) in the diagnosis of feline acute pancreatitis. We used 13 healthy cats and 10 cats with a diagnosis of acute pancreatitis. The mean serum fTLI and plasma TAP concentrations were significantly higher in the cats with acute pancreatitis than in the healthy cats (P < 0.05); the mean urine TAP concentrations and the median urine TAP:Cr ratios were not significantly different. Among the cats examined in this study, there was no benefit of plasma TAP over serum fTLI in the evaluation of suspected acute pancreatitis.
Allen
Heidi S
HS
The Bobst Hospital, Animal Medical Center, New York, New York 10021, USA. RUN.DVM@Verizon.net
Steiner
Jörg
J
Broussard
John
J
Mansfield
Caroline
C
Williams
David A
DA
Jones
Boyd
B
D000208:Acute Disease; D000818:Animals; D015415:Biomarkers; D016022:Case-Control Studies; D002371:Cat Diseases / Q000097:blood* / Q000175:diagnosis / Q000652:urine*; D002415:Cats; D003404:Creatinine / Q000652:urine; D005260:Female; D008297:Male; D009842:Oligopeptides / Q000097:blood / Q000652:urine; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis / Q000652:urine / Q000662:veterinary*
D015415:Biomarkers; D009842:Oligopeptides; C080396:trypsinogen activation peptide; D003404:Creatinine