Osteopontin dysregulation and lytic bone lesions in multiple myeloma.
Osteopontin (OPN), a secreted phosphoprotein involved in immune regulation and bone homeostasis, is a major component of bone, the natural habitat of long-lived plasma cells and multiple myeloma (MM). We show that only some MM cell lines and primary patient samples express OPN at high levels. High OPN expression inversely correlates with bone disease. When we subdivide MM into molecular subtypes, OPN is significantly upregulated in patients with maf translocations, particularly in the fraction lacking bone disease. OPN is produced in osteolytic lesions: we propose that MM-derived OPN plays a critical role in bone disease by protecting bone from destruction.
Robbiani
Davide F
DF
Department of Medicine, Division of Hematology and Medical Oncology, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY, USA.
Colon
Kaity
K
Ely
Sarah
S
Ely
Scott
S
Chesi
Marta
M
Bergsagel
P Leif
PL
D045744:Cell Line, Tumor; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications*; D009363:Neoplasm Proteins / Q000032:analysis; D010014:Osteolysis / Q000209:etiology*; D053495:Osteopontin / Q000032:analysis* / Q000502:physiology; D051257:Proto-Oncogene Proteins c-maf / Q000032:analysis*; D012334:RNA, Neoplasm / Q000032:analysis; D014407:Tumor Cells, Cultured; D015854:Up-Regulation
C495607:MAF protein, human; D009363:Neoplasm Proteins; D051257:Proto-Oncogene Proteins c-maf; D012334:RNA, Neoplasm; D053495:Osteopontin