New antifungal flavonoid glycoside from Vitex negundo.
Flavonoids are ubiquitous in photosynthesizing cells and are common part of human diet. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases. Increasingly, this class of natural products is becoming the subject of anti-infective research. Our bioactivity guided fractionation of ethanolic extract of leaves of Vitex negundo resulted in the isolation of new flavone glycoside (4) along with five known compounds 1-3, 5 and 6. All the isolated compounds were evaluated for their antimicrobial activities. The new flavone glycoside 4 and compound 5 were found to have significant antifungal activity against Trichophyton mentagrophytes and Cryptococcus neoformans at MIC 6.25 microg/ml.
Sathiamoorthy
B
B
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Gupta
Prasoon
P
Kumar
Manmeet
M
Chaturvedi
Ashok K
AK
Shukla
P K
PK
Maurya
Rakesh
R
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D014249:Trichophyton / Q000187:drug effects*; D020950:Vitex / Q000737:chemistry*
D000935:Antifungal Agents; D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts