Molecular basis of inherited renal lithiasis.
Idiopathic calcium oxalate stone formation results from an interaction between genetic and environmental factors. Clearly identifiable risk factors for the disease that have a significant genetic influence are the excretions of calcium, oxalate and citrate. Candidate genes that may be responsible for these effects have been proposed. With the large-scale sequencing of the human genome and the identification of genetic polymorphisms, it is only a matter of time before these genes and the sequence differences within them that are associated with susceptibility to the disease are conclusively identified.
Holmes
R P
RP
Department of Urology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Assimos
D G
DG
Goodman
H O
HO