title: Rabbit antithymocyte globulin related decrease in platelet count reduced risk of pediatric renal transplant graft thrombosis.
abstract: Graft thrombosis is a serious complication in pediatric renal transplantation. We assess a potential protective effect for the decrease in platelet count associated with RATG therapy against pediatric renal transplant graft vascular thrombosis. Between January 1986 and December 1998, 120 kidney transplants were performed in 95 pediatric recipients. Patients were divided into two groups. Group 1 (n = 61), non-RATG group received cyclosporine, azathioprine and steroids, while group 2 (n = 59), RATG group, received in addition, RATG at day 1 and continued for 4-10 days postoperatively. Platelet count prior to transplant, median change in absolute platelet count at 1 and 3 days post-transplant was recorded. Graft thrombosis incidence was examined. Six grafts (5%) developed thrombosis. All were in group 1 (p = 0.028). Median pretransplant platelet count (x10(9)/L) in group 1 was 283 vs. 280 in group 2 (p = 0.921). Median decrease in absolute platelet count (x10(9)/L) from pretransplant levels at one and three days post-transplant for group 1 and 2 was 18 vs. 83 (p </= 0.001) and 39 vs. 105 (p </= 0.001), respectively. Graft thrombosis risk factors were similar in both groups. RATG use was statistically significant (p = 0.044) for reduced risk of graft thrombosis in multivariate analysis. Patients receiving RATG showed significant decrease in both platelet count and graft thrombosis incidence. A role for RATG related effect on platelet count is assumed.
authors.affiliation: Department of Urology and Transplantation, Beaumont Hospital, Dublin, Ireland.
authors.forename: M H
authors.initials: MH
authors.lastname: Kamel
authors.forename: P
authors.initials: P
authors.lastname: Mohan
authors.forename: P J
authors.initials: PJ
authors.lastname: Conlon
authors.forename: D M
authors.initials: DM
authors.lastname: Little
authors.forename: P
authors.initials: P
authors.lastname: O'Kelly
authors.forename: D P
authors.initials: DP
authors.lastname: Hickey
mesh_terms: D000293:Adolescent; D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D010976:Platelet Count; D011183:Postoperative Complications; D011817:Rabbits; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000961:Antilymphocyte Serum