title: Morphometric and morphological features of the ventral prostate in rats submitted to chronic nicotine and alcohol treatment.
abstract: Clinical studies analyzing simultaneous nicotine-alcohol use by patients showed important alterations in various organic systems such as: respiratory, digestory, and genital. Also, the prostatic morphology and physiology have been analyzed, specially due to large occurrence of prostatic diseases. Then, this work aimed at determining the structure and ultrastructure of the prostatic stroma and epithelium, as well as the stroma epithelium interactions from rats submitted to simultaneous long-term alcohol-nicotine treatment. A total of 40 male rats were divided into four groups: control group (10 animals) received tap water; alcoholic group (10 animals) received diluted 10% Gay Lussac ethanol; nicotine group (10 animals) received a 0.125mg/100g of body weight dose of nicotine injected subcutaneosly on a daily basis; nicotine-alcohol group (10 animals) received simultaneous alcohol and nicotine treatment. After 90 days of treatment, the animals were sacrificed and samples from the ventral lobe of the prostate were collected and processed for transmission electron and light microscopies. The results showed atrophied epithelium; prostatic intra-epithelial neoplasia; dilated cisterns of the granular endoplasmic reticulum, large amounts of collagen fibers besides inflammatory cells, specially in the alcoholic and nicotine-alcohol groups. Therefore, it could be concluded that the association between alcohol and nicotine caused the impairment of the prostatic secretory process. Moreover, this association is related to prostatic pathogenesis, which could lead to late glandular malignancy.
authors.affiliation: Department of Anatomy, Institute of Biology, The State University of Campinas, Box 6109, São Paulo, Brazil.
authors.forename: W J
authors.initials: WJ
authors.lastname: Fávaro
authors.forename: V H A
authors.initials: VH
authors.lastname: Cagnon
mesh_terms: D000818:Animals; D001284:Atrophy / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D002462:Cell Membrane / Q000187:drug effects / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D002492:Central Nervous System Depressants / Q000633:toxicity; D002908:Chronic Disease; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000473:pathology; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000431:Ethanol / Q000633:toxicity*; D005298:Fertility / Q000187:drug effects / Q000502:physiology; D008297:Male; D046529:Microscopy, Electron, Transmission; D009538:Nicotine / Q000633:toxicity*; D018722:Nicotinic Agonists / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D011469:Prostatic Diseases / Q000139:chemically induced* / Q000473:pathology* / Q000503:physiopathology; D019048:Prostatic Intraepithelial Neoplasia / Q000139:chemically induced* / Q000473:pathology; D011472:Prostatitis / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017154:Stromal Cells / Q000187:drug effects / Q000473:pathology
chemical_list: D002492:Central Nervous System Depressants; D018722:Nicotinic Agonists; D000431:Ethanol; D009538:Nicotine