title: Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains.
abstract: The pharmacokinetic profile of linezolid in cerebrospinal fluid (CSF) in five neurointensive care patients with staphylococcal ventriculitis was studied. The mean area under concentration-time curve (+/- standard deviation) was 63 +/- 18.9 mg x h/liter, with a CSF-to-plasma ratio of 0.8 +/- 0.3. Times above MIC in CSF were 99.8% and 57.2% for pathogens with MICs of 2 mg/liter and 4 mg/liter, respectively.
authors.affiliation: Innsbruck Medical University, Clinical Department of Neurology, Neurological Intensive Care Unit, Anichstrasse 35, 6020 Innsbruck, Austria. ronny.beer@uibk.ac.at
authors.forename: Ronny
authors.initials: R
authors.lastname: Beer
authors.forename: Klaus W
authors.initials: KW
authors.lastname: Engelhardt
authors.forename: Bettina
authors.initials: B
authors.lastname: Pfausler
authors.forename: Gregor
authors.initials: G
authors.lastname: Broessner
authors.forename: Raimund
authors.initials: R
authors.lastname: Helbok
authors.forename: Peter
authors.initials: P
authors.lastname: Lackner
authors.forename: Christian
authors.initials: C
authors.lastname: Brenneis
authors.forename: Stefan T
authors.initials: ST
authors.lastname: Kaehler
authors.forename: Apostolos
authors.initials: A
authors.lastname: Georgopoulos
authors.forename: Erich
authors.initials: E
authors.lastname: Schmutzhard
mesh_terms: D000081:Acetamides / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D002552:Cerebral Ventricles / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D004660:Encephalitis / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D000069349:Linezolid; D008297:Male; D008657:Metabolic Clearance Rate; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D023303:Oxazolidinones / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects*
chemical_list: D000081:Acetamides; D023303:Oxazolidinones; D000069349:Linezolid