title: Indications and results with cryoplasty in the treatment of infrainguinal arterial occlusive disease.
abstract: Percutaneous transluminal angioplasty of the superficial femoral and popliteal arteries has been an accepted therapy for short focal stenosis. Elastic recoil and flow-limiting dissection have limited the durability of angioplasty, especially in long lesions and total occlusions. Cryoplasty couples cold therapy with angioplasty to induce mechanical and biologic effects to reduce elastic recoil and potentially to reduce restenosis. The mechanical and biologic mechanisms of this therapy are discussed. The results of cryoplasty for femoropopliteal lesions from a single-center series and a multicenter registry are reviewed. Cryoplasty appears to improve patency over conventional angioplasty and to reduce the need for bailout stenting in femoropopliteal stenoses and occlusions < 10 cm in length. Cryoplasty appears to be promising to treat critical limb ischemia in patients with tibial disease.
authors.affiliation: Department of Vascular Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.Lydens@ccf.org
authors.forename: Sean P
authors.initials: SP
authors.lastname: Lyden
mesh_terms: D000800:Angioplasty, Balloon / Q000295:instrumentation / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000628:therapy*; D017679:Cryotherapy / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005263:Femoral Artery; D006801:Humans; D011150:Popliteal Artery; D016896:Treatment Outcome; D014654:Vascular Patency