Dactinomycin-induced, severe lichenoid eruption in a child.
There is little information in the medical literature about skin rashes associated with dactinomycin in the absence of radiotherapy. We report a 12-month-old male child who developed a severe cutaneous reaction that consisted of a widespread pruritic papular eruption associated with fever and a poor general state after dactinomycin administration. Skin biopsy specimen findings confirmed the diagnosis of lichenoid eruption. The rash improved with topical steroid treatment and completely resolved within 1 month with persistence of a residual mild hyperpigmentation. Dactinomycin administration was discontinued for the remaining cycles of chemotherapy.
Ridola
V
V
Department of Pediatric Oncology, Gustave Roussy Institute, Villejuif, France.
Mahé
E
E
Fawaz
O
O
Galmiche
L
L
Patte
C
C
Grill
J
J
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D003609:Dactinomycin / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D017512:Lichenoid Eruptions / Q000139:chemically induced* / Q000473:pathology; D008297:Male
D000903:Antibiotics, Antineoplastic; D003609:Dactinomycin