title: Serial optical coherence tomography of subthreshold diode laser micropulse photocoagulation for diabetic macular edema.
abstract: To use serial optical coherence tomography (OCT) to evaluate low-intensity, high-density subthreshold diode laser micropulse photocoagulation treatment of clinically significant diabetic macular edema.
  
  
  
  Eighteen consecutive eyes of 14 patients with clinically significant diabetic macular edema and a minimum foveal thickness of 223 microm or greater were prospectively evaluated by OCT preoperatively and 1, 4, and 12 weeks following treatment.
  
  
  
  Overall, estimated macular edema 3 months postoperatively (minimum foveal thickness--223 microm) was reduced a mean of 24% (P = .02). Eleven eyes treated for recurrent or persistent clinically significant diabetic macular edema following prior treatment more than 3 months before study entry were most improved, with a mean reduction in estimated macular edema 3 months postoperatively of 59%. No treatment complications were observed. No patient demonstrated laser lesions following treatment.
  
  
  
  Low-intensity, high-density subthreshold diode laser micropulse photocoagulation can reduce or eliminate clinically significant diabetic macular edema measured by OCT. Further study is warranted.
authors.forename: Jeffrey K
authors.initials: JK
authors.lastname: Luttrull
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Spink
mesh_terms: D003930:Diabetic Retinopathy / Q000601:surgery*; D003941:Diagnostic Techniques, Ophthalmological; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D017075:Laser Coagulation / Q000379:methods*; D008269:Macular Edema / Q000175:diagnosis* / Q000601:surgery*; D011446:Prospective Studies; D012008:Recurrence; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity