title: Voltage-gated potassium channel antibodies associated limbic encephalitis in a patient with invasive thymoma.
abstract: Recently, limbic encephalitis (LE) associated with Voltage-gated potassium channel antibody (VGKC-Ab) has been postulated as a new autoimmune disorder. Most previously reported cases of VGKC-Ab-associated LE were non-paraneoplastic, and reports of a paraneoplastic type are rare. Here we describe a 59-year-old woman with paraneoplastic VGKC-Ab-associated LE preceding the recurrence of invasive thymoma. There was a close temporal relationship between the clinical course and the changes of the VGKC-Ab titer. Unlike many of the non-paraneoplastic VGKC-Ab-associated LE cases, our cases showed the more extensive high intensity lesions on MRI and the absence of seizure and hyponatremia.
authors.affiliation: Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Kagoshima, Japan. ohshitat@hiroshima-u.ac.jp
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ohshita
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kawakami
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kohriyama
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
authors.forename: Masayasu
authors.initials: M
authors.lastname: Matsumoto
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D006179:Gyrus Cinguli / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D006624:Hippocampus / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007010:Hyponatremia / Q000209:etiology / Q000503:physiopathology; D020363:Limbic Encephalitis / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D008032:Limbic System / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000276:immunology; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D017397:Prefrontal Cortex / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D013945:Thymoma / Q000150:complications* / Q000276:immunology* / Q000503:physiopathology
chemical_list: D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated