title: CD8-positive T cell-induced liver damage was found in a patient with polymyositis.
abstract: We describe a case of polymyositis (PM) with liver injury that occurred in a patient with rheumatoid arthritis (RA). A 74-year-old woman who had a 12-year history of RA was admitted to our hospital because of muscle weakness and liver dysfunction. CD8-positive T cell infiltration was found in the interstitium of both the liver and muscle. In addition to the administration of a large amount of prednisolone (PSL), high-dose intravenous immunoglobulin (IVIG) successfully improved myositis and hepatitis. Our case indicates the pathogenic potential of CD8-positive T cells in PM-associated liver injury.
authors.affiliation: Divisions of Rheumatology, Ohta Nishinouchi Hospital, Koriyama.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Isao
authors.initials: I
authors.lastname: Takeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanno
authors.forename: Toshiki
authors.initials: T
authors.lastname: Nakahara
authors.forename: Hajime
authors.initials: H
authors.lastname: Odajima
authors.forename: Reiji
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008107:Liver Diseases / Q000276:immunology* / Q000473:pathology; D017285:Polymyositis / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D011239:Prednisolone