title: Synthesis and anti-microbial activity of pyrazolylbisindoles--promising anti-fungal compounds.
abstract: A series of pyrazolylbisindole derivatives have been synthesized by reacting substituted pyrazole aldehydes with substituted indoles using phosphotungstic acid, a Keggin type heteropoly acid as catalyst. The synthesized pyrazolylbisindoles were evaluated for anti-microbial activities. The effect of pyrazolylbisindoles on the mycelial growth of plant pathogenic fungi is revealed. Entries 3c and 3d emerged as the most interesting compounds in this series exhibiting excellent anti-fungal activity.
authors.affiliation: Organic Chemistry Division, Central Leather Research Institute, Chennai 600 020, India.
authors.forename: Ganesabaskaran
authors.initials: G
authors.lastname: Sivaprasad
authors.forename: Paramasivan T
authors.initials: PT
authors.lastname: Perumal
authors.forename: Vaiyapuri R
authors.initials: VR
authors.lastname: Prabavathy
authors.forename: Narayanasamy
authors.initials: N
authors.lastname: Mathivanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007211:Indoles; D011720:Pyrazoles