Hepatocyte transplantation: State of the art.
Advances in biotechnology have allowed hepatocyte transplantation as a relevant proposition to treat liver disease. This procedure may change the crescent mortality in liver transplantation waiting lists due global organ shortage. Recent clinical trials have described promising results of hepatocyte transplantation for acute, acute-on-chronic and metabolic liver disease. In this report, we discuss progresses regarding hepatocyte culture, cryopreservation systems, hepatocyte immortalization, suitable recipient site for hepatocyte engraftment, cell differentiation and fusion into hepatocytes, current clinical trials, and summarize the bioartificial liver systems. These progressions motivate expectation concerning hepatocyte transplantation as a consistent therapy for liver disease.
Galvão
Flávio Henrique Ferreira
FH
Laboratório de Transplante Experimental da Disciplina de Transplante e Cirurgia do Fígado (LIM 37), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
de Andrade Júnior
Dahir Ramos
DR
de Andrade
Dahir Ramos
DR
Martins
Bruno Costa
BC
Marson
Allan Garms
AG
Bernard
Christiano Vinicius
CV
Dos Santos
Sânia Alves
SA
Bacchella
Telesforo
T
Machado
Marcel Cerqueira César
MC