A general and efficient FeCl3-catalyzed nucleophilic substitution of propargylic alcohols.
A general and efficient FeCl3-catalyzed substitution reaction of propargylic alcohols with carbon- and heteroatom-centered nucleophiles such as allyl trimethylsilane, alcohols, aromatic compounds, thiols, and amides, leading to the construction of C-C, C-O, C-S and C-N bonds, has been developed.
Zhan
Zhuang-ping
ZP
Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China. zpzhan@xmu.edu.cn
Yu
Jing-liang
JL
Liu
Hui-juan
HJ
Cui
Yuan-yuan
YY
Yang
Rui-feng
RF
Yang
Wen-zhen
WZ
Li
Jun-ping
JP
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides; D005290:Ferric Compounds / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
D000480:Alkynes; D002712:Chlorides; D005290:Ferric Compounds; D020005:Propanols; C028255:propargyl alcohol; C024555:ferric chloride