title: The adipokine visfatin is markedly elevated in obese children.
abstract: OBJECTIVE
  The insulin-mimetic adipocytokine visfatin has been linked to adiposity and the metabolic syndrome.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Eighty-three nondiabetic obese children and 40 healthy controls.
  
  
  METHODS
  We analyzed plasma visfatin concentrations to assess whether this adipokine is associated with adiposity.
  
  
  RESULTS
  Plasma visfatin concentrations were nearly 2-fold higher in obese children (mean, 1.1 ng/mL; 95% CI, 0.2-6.6) than in controls (0.6 ng/mL, 95% CI, 0.6 to 0.6; P < 0.001). No relationship was detectable between visfatin and other subject characteristics, hsCRP or the lipid profile.
  
  
  CONCLUSIONS
  Visfatin may be involved in the development of metabolic derangements in obese children.
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Austria.
authors.forename: Dominik G
authors.initials: DG
authors.lastname: Haider
authors.forename: Gregor
authors.initials: G
authors.lastname: Holzer
authors.forename: Georg
authors.initials: G
authors.lastname: Schaller
authors.forename: Daniel
authors.initials: D
authors.lastname: Weghuber
authors.forename: Kurt
authors.initials: K
authors.lastname: Widhalm
authors.forename: Oswald
authors.initials: O
authors.lastname: Wagner
authors.forename: Stylianos
authors.initials: S
authors.lastname: Kapiotis
authors.forename: Michael
authors.initials: M
authors.lastname: Wolzt
mesh_terms: D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology*; D054409:Nicotinamide Phosphoribosyltransferase; D009765:Obesity / Q000097:blood* / Q000150:complications
chemical_list: D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human