title: "Pocket dendrimers" as nanoscale receptors for bimolecular guest accommodation.
abstract: A new series of dendrimer receptors was prepared by combining a (tetraphenylporphinato)zinc(II) core and benzyl ether type dendritic substituents. Since one direction of the (tetraphenylporphinato)zinc(II) was not substituted by a dendritic residue, the resulting unsymmetrical dendrimers have "pockets" available for access of external substrates. Molecular modeling, NMR measurements, and zinc-coordination experiments revealed that the third-generation dendrimer of this type exhibited characteristic inclusion of coordinative pyridine guests. When diamidopyridine moiety was introduced into the dendrimer pocket, a thymine derivative was bound through complementary hydrogen bonding. Two different kinds of substrates, pyridine and thymine derivatives, were simultaneously accommodated in the nanoscale pocket and bimolecular guest accommodation was realized with the designed dendrimer receptor.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shinoda
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ohashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsukube
mesh_terms: D001669:Biochemical Phenomena; D001671:Biochemistry; D050091:Dendrimers / Q000737:chemistry*; D006860:Hydrogen Bonding; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D015032:Zinc / Q000737:chemistry
chemical_list: D050091:Dendrimers; D008024:Ligands; D011166:Porphyrins; D011725:Pyridines; D015032:Zinc; C023666:pyridine