Proper use of phosphodiesterase inhibitors according to the situations.
We came across a case who because of sustained hypotension with normal cardiac output was given amrinone which offered an initial excellent response but showed impotency later and its replacement by milrinone dramatically improved the hemodynamic status. The ensuing hypotension was thought to be the consequence of the use of amrinone which was given to treat hypotension in conjunction with fluid therapy; besides, it also induced pulmonary hypertension. Therefore, milrinone was given to replace amrinone and was successfully to turn the tide. It is our suggestion that if the use of a phosphodiesterase (PDE) inhibitor is indicated but its side effects are enhanced to refute its use, the application of a different PDE inhibitor should be kept in mind.
Tanwiphongtrakun
Thiranat
T
Department of Anesthesiology, Nara Medical University, Kashihara Nara, Japan.
Inoue
Satoki
S
Furuya
Hitoshi
H
D000368:Aged; D000676:Amrinone / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D008297:Male; D020105:Milrinone / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*
D010726:Phosphodiesterase Inhibitors; D020105:Milrinone; D000676:Amrinone