A short overview on the role of alpha-synuclein and proteasome in experimental models of Parkinson's disease.
The Ubiquitin Proteasome System is a multi-enzymatic pathway which degrades polyubiquinated soluble cytoplasmic proteins. This biochemical machinery is impaired both in sporadic and inherited forms of Parkinsonism. In the present paper we focus on the role of the pre-synaptic protein alpha-synuclein in altering the proteasom based on the results emerging from experimental models showing a mechanistic chain of events between altered alpha-synuclein, proteasome impairment and formation of neuronal inclusions and catecholamine cell death.
Giorgi
F S
FS
Department of Neuroscience, Section of Neurology, University of Pisa, Italy.
Bandettini di Poggio
A
A
Battaglia
G
G
Pellegrini
A
A
Murri
L
L
Ruggieri
S
S
Paparelli
A
A
Fornai
F
F
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000662:Amphetamines; D000818:Animals; D004195:Disease Models, Animal; D015259:Dopamine Agents; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism; D051844:alpha-Synuclein / Q000235:genetics / Q000502:physiology*
D000662:Amphetamines; D015259:Dopamine Agents; D025801:Ubiquitin; D051844:alpha-Synuclein; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D046988:Proteasome Endopeptidase Complex