title: Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta.
abstract: BACKGROUND
  Adiponectin (APN) concentration in umbilical cord serum is higher than that in adult serum. Except for the positive association between birth weight and cord APN concentration, little is known about the pathophysiological function of APN in fetal development.
  
  
  OBJECTIVE
  The objective of this study was to evaluate the relationship of cord serum APN and IGF-I concentrations with the development of the fetoplacental unit.
  
  
  METHODS
  Umbilical cord serum APN and IGF-I concentrations were measured in term singleton deliveries (n = 94). The association of cord APN and IGF-I concentrations was evaluated in relation to fetal weight, placental weight, and fetoplacental (F/P) weight ratio.
  
  
  RESULTS
  Mean concentrations and sd of APN and IGF-I were 36.1 +/- 14.0 microg/ml and 58.6 +/- 27.0 ng/ml, respectively. Cord APN concentration was positively associated with F/P weight ratio (r = 0.375, P < 0.001) as well as fetal weight (r = 0.389, P < 0.001) but not placental weight. Cord IGF-I concentration was positively associated with fetal weight (r = 0.405, P < 0.001) and placental weight (r = 0.400, P < 0.001) but not F/P weight ratio. In multiregression analysis, only APN concentration resulted in a significant determinant of F/P weight ratio among variables (beta = 0.376, P < 0.001).
  
  
  CONCLUSIONS
  In cord hyperadiponectinemia, fetuses tend to be disproportionately larger for their placental weight and vice versa in cord hypoadiponectinemia. APN is shown to be the first biomarker positively associated with F/P weight ratio.
authors.affiliation: Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Izumi, Osaka 594-1101, Japan. kozo1223@aol.com
authors.forename: Kozo
authors.initials: K
authors.lastname: Kadowaki
authors.forename: Masako
authors.initials: M
authors.lastname: Waguri
authors.forename: Isao
authors.initials: I
authors.lastname: Nakanishi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyashita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakayama
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Suehara
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Tomio
authors.initials: T
authors.lastname: Fujita
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001724:Birth Weight; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D047109:Fetal Development / Q000502:physiology; D020567:Fetal Weight / Q000502:physiology*; D005333:Fetus / Q000033:anatomy & histology; D005865:Gestational Age; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D009035:Mothers; D015999:Multivariate Analysis; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology*; D010929:Placentation; D011247:Pregnancy; D012044:Regression Analysis
chemical_list: D052242:Adiponectin; D007334:Insulin-Like Growth Factor I