[Colonic perforation in a patient treated with combination chemotherapy for recurrent ovarian clear cell adenocarcinoma].
BACKGROUND
Colonic perforation due to colitis is a known and reported side effect of chemotherapy.


METHODS
A 53-year-old woman was treated with combination chemotherapy of irinotecan plus cisplatin for a recurrent ovarian clear cell adenocarcinoma. Steroid was also used for suspected interstitial pneumonia. After two cycles of treatment, she developed a colonic perforation. Emergency laparotomy was not performed because of poor performance status with multiple lung metastases, pleural effusion and pericardial effusion. Colonoscopy showed a perforated wall at the cecum, and a long tube with balloon was inserted for occlusion. In addition, a peritoneal drainage tube was inserted. Oral intake could be restarted for a while, but she died from tumor progression one and a half months after the diagnosis of perforation.


CONCLUSIONS
Non-surgical management with peritoneal drainage and ileus tube was useful in this case of colonic perforation for preserving oral intake and quality of life.
Shitara
Kohei
K
Dept. of Medical Oncology, Misawa City Hospital.
Munakata
Masaki
M
Ishiguro
Atsushi
A
Kudo
Toshihiro
T
Okada
Ritsuko
R
Tomioka
Rumiko
R
Mitobe
Sumako
S
Yokoyama
Shin
S
Sakata
Yuh
Y
D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002429:Cecal Diseases / Q000175:diagnosis / Q000209:etiology*; D002945:Cisplatin / Q000008:administration & dosage; D003113:Colonoscopy; D004322:Drainage; D004334:Drug Administration Schedule; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016066:Pleural Effusion, Malignant / Q000209:etiology
D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin