Pharmacokinetics of inhaled anesthetics in green iguanas (Iguana iguana).
OBJECTIVE
To test the hypothesis that differences in anesthetic uptake and elimination in iguanas would counter the pharmacokinetic effects of blood:gas solubility and thus serve to minimize kinetic differences among inhaled agents.


METHODS
6 green iguanas (Iguana iguana).


METHODS
Iguanas were anesthetized with isoflurane, sevoflurane, or desflurane in a Latin-square design. Intervals from initial administration of an anesthetic agent to specific induction events and from cessation of administration of an anesthetic agent to specific recovery events were recorded. End-expired gas concentrations were measured during anesthetic washout.


RESULTS
Significant differences were not detected for any induction or recovery events for any inhalation agent in iguanas. Washout curves best fit a 2-compartment model, but slopes for both compartments did not differ significantly among the 3 anesthetics.


CONCLUSIONS
Differences in blood:gas solubility for isoflurane, sevoflurane, and desflurane did not significantly influence differences in pharmacokinetics for the inhalation agents in iguanas.
Brosnan
Robert J
RJ
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Pypendop
Bruno H
BH
Barter
Linda S
LS
Hawkins
Michelle G
MG
D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics; D000818:Animals; D000077335:Desflurane; D005260:Female; D006207:Half-Life; D007076:Iguanas / Q000378:metabolism*; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D008297:Male; D008738:Methyl Ethers / Q000493:pharmacokinetics*; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane