Schools of pharmacology: retinoid update.
The most widely used retinoids include topical tretinoin (Retin-A), adapalene (Differin), topical tazarotene (Tazorac), isotretinoin (Accutane), and acitretin (Soriatane). This article will review new uses and developments in tazarotene (its failure to secure FDA approval in oral form for psoriasis), adapalene (its new 0.3% gel form and use in rosacea), alitretinoin (its use in photoaging), bexarotene (its use for psoriasis and chronic hand dermatitis), isotretinoin (the IPledge program, its use for neuroblastoma and branded formulation pharmacological superiority to generics), and retinoic acid metabolism-blocking agents (RAMBAs) (liarazole use for ichthyosis and psoriasis).
Scheinfeld
Noah
N
St. Luke's-Roosevelt Hospital Center, New York, NY, USA.
D000068816:Adapalene; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000627:therapeutic use; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy*; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use
D007641:Keratolytic Agents; D009281:Naphthalenes; D009539:Nicotinic Acids; D012176:Retinoids; D000068816:Adapalene; D014212:Tretinoin; C086827:tazarotene; D015474:Isotretinoin