title: Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments.
abstract: We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory impairment (increased aversive arm time) but only 0.5 mg/kg reserpine decreased locomotion (entries in enclosed arms). The results suggest that the DAVT evaluation in reserpine-treated mice can be a useful model for studying cognitive deficits accompanied by motor impairments.
authors.affiliation: Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Rita C
authors.initials: RC
authors.lastname: Carvalho
authors.forename: Camilla C
authors.initials: CC
authors.lastname: Patti
authors.forename: André L
authors.initials: AL
authors.lastname: Takatsu-Coleman
authors.forename: Sonia R
authors.initials: SR
authors.lastname: Kameda
authors.forename: Claudio F
authors.initials: CF
authors.lastname: Souza
authors.forename: Lucia
authors.initials: L
authors.lastname: Garcez-do-Carmo
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Abílio
authors.forename: Roberto
authors.initials: R
authors.lastname: Frussa-Filho
authors.forename: Regina H
authors.initials: RH
authors.lastname: Silva
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000150:complications*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000150:complications*; D012110:Reserpine / Q000494:pharmacology*
chemical_list: D018759:Adrenergic Uptake Inhibitors; D012110:Reserpine