A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia.
Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.
Goemans
Bianca F
BF
Zwaan
Christian M
CM
Reinhardt
Dirk
D
Gibson
Brenda E S
BE
Hählen
K
K
Kaspers
Gert Jan L
GJ
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology; D008081:Liposomes / Q000008:administration & dosage; D008297:Male
D008081:Liposomes; D003630:Daunorubicin