title: [A study on expression of HIF-1alpha and EPO in the hippocampus of rats with vascular dementia].
abstract: OBJECTIVE
  To observe the expression rule of hypoxia inducible factor-1 (HIF-1alpha) and erythropoietion (EPO) in the formation of vascular dementia (VD) and investigate the possible pathogenesis of VD.
  
  
  METHODS
  Rats of experimental group were treated with a permanent bilateral common carotid arteries (CCA) occlusion (2-VO) for establishing vascular dementia model. Rats were evaluated on learning-memory ability by Y-type water maze test. The dynamic expression of HIF-1alpha and EPO in hippocampal CA1 region were measured by immunohistochemical assay method.
  
  
  RESULTS
  (1) The learning-memory ability of rats in VD groups was progressively decreased as the ischemic duration prolonged (P < 0.05); (2) In VD group, the expression of HIF-1alpha and EPO in hippocampal CA1 region were most obvious at 1 w, and then declined progressively but still above the normal level (P < 0.01); (3) In VD group, the expression of HIF-1alpha and EPO at each ischemic point and their corresponding learning-memory ability were in significant correlation at the 0.01 level.
  
  
  CONCLUSIONS
  Both HIF-1alpha and EPO contribute to the formation of VD, and HIF-1/EPO anoxic signal transduction may play a protecting role in this process.
authors.affiliation: Department of Neurology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Zhang
authors.forename: Hai-qin
authors.initials: HQ
authors.lastname: Wu
authors.forename: Hai-xiong
authors.initials: HX
authors.lastname: Zhang
authors.forename: Gui-lian
authors.initials: GL
authors.lastname: Zhang
authors.forename: Shu-qin
authors.initials: SQ
authors.lastname: Zhan
mesh_terms: D000818:Animals; D015140:Dementia, Vascular / Q000378:metabolism* / Q000503:physiopathology; D004921:Erythropoietin / Q000096:biosynthesis* / Q000235:genetics; D006624:Hippocampus / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D018782:Maze Learning; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D004921:Erythropoietin