title: Glucose-lowering effect of powder formulation of African black tea extract in KK-A(y)/TaJcl diabetic mouse.
abstract: We observed the suppressive effect of a powder formulation of African black tea extract prepared from the leaves of Camellia sinensis on type 2 non-insulin dependent diabetic mice, KK-A(y)/TaJcl. Black tea extract significantly showed suppressive effect of the elevation of blood glucose on oral glucose tolerance test of 8 week-old KK-A(y)/TaJcl mice (P < 0.05). Long-term treatment with black tea extract showed significant suppression of post-prandial blood glucose and obesity (P < 0.05). The weight of the intestine of mice treated with black tea extract was significantly reduced (P < 0.05). From these results, African black tea used in this study showed a suppressive effect on the elevation of blood glucose during food intake and the body weight.
authors.affiliation: Department of Microbiology, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku Kawasaki, Kanagawa 216-8511, Japan. ysshoji@marianna-u.ac.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shoji
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakashima
mesh_terms: D016475:3T3 Cells; D017667:Adipocytes / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects; D000818:Animals; D015415:Biomarkers; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D028241:Camellia sinensis / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy* / Q000235:genetics; D004326:Drinking / Q000187:drug effects; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000494:pharmacology; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000494:pharmacology; D011208:Powders
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D011208:Powders; D002784:Cholesterol