The influence of genomics on outcome after cardiovascular surgery.
Recent findings in molecular research suggest that the outcome of cardiovascular surgery is at least partly determined by the individual patient's genetic predisposition to react to surgical trauma and extracorporal circulation. The activation of cellular as well as humoral cascades occurs in the perioperative period, and influences the extent of pro- and anticoagulation and pro- and anti-inflammation. These events contribute to the incidence and severity of perioperative ischaemia or organ dysfunction, and thus determine adverse outcomes in patients undergoing cardiac surgery. Candidate genes that are possibly involved in the development of adverse outcomes not only consist of genes relevant to the field of coagulation and inflammation, but also genes functioning in lipid metabolism, ion channels, membrane integrity and others. Genomic variations may prove to serve as future diagnostic tools for the risk stratification of patients undergoing cardiovascular surgery.
Stüber
Frank
F
Klinik und Poliklinik für Anästhesiologie und Spezielle Intensivmedizin, Universitätsklinkum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany. fstuber@uni-bonn.de
Hoeft
Andreas
A