Protocols for optimizing MS/MS parameters with an ion-trap GC-MS instrument.
The product ion spectrum allows us to achieve very selective detection of pesticides and to eliminate the ambiguities caused by more conventional analytical approaches. Owing to the enhanced capabilities of GC/MS/MS for multiresidue pesticides, the development of a GC/MS/MS pesticides library will be useful. The aim of this study was to develop a sensitive and specific analytical method for the identification and quantification of compounds without the need of a time-consuming procedure. Two methods were studied in order to optimize the nonresonant conditions of dissociation of five pesticides (deltamethrin, metalaxyl, myclobutanil, procymidone, pirimicarb). The first permits a systematic investigation of the influence of the qz trapping parameter on sensitivity in precursor ion detection and on the efficiency of collision-induced dissociation (CID). The second is more suited for analytical laboratories and less time-consuming and allows us to reach similar results: the experiments were conducted step by step at a constant stability parameter.
Béguin
Sylvie
S
Groupement Interrégional de Recherche sur les Produits Agropharmaceutiques, UMR-MA 105 Paysage et Biodiversité, Angers Technopôle, 8 rue H. Becquerel, 49070 Beaucouzé, France.
Jadas-Hécart
Alain
A
Tabet
Jean-Claude
JC
Communal
Pierre-Yves
PY
D008401:Gas Chromatography-Mass Spectrometry; D007202:Indicators and Reagents; D010573:Pesticide Residues / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization
D007202:Indicators and Reagents; D010573:Pesticide Residues