title: Evaluation of the antibacterial activity of a special silk textile in the treatment of atopic dermatitis.
abstract: BACKGROUND
  Increased skin Staphylococcus aureus colonization is frequently found in atopic patients. The reduction of local overinfection decreases skin inflammation and improves the flares.
  
  
  OBJECTIVE
  To evaluate the effectiveness of the antimicrobial activity of a silk fabric (MICROAIR DermaSilk) coated with alkoxysilane quaternary ammonium with durable antimicrobial properties (AEGIS AEM 5572/5) in children affected by atopic dermatitis (AD).
  
  
  METHODS
  Sixteen children, 12 affected by AD with symmetric eczematous lesions on the antecubital areas and 4 without any cutaneous disease, used, for 7 days, tubular arm covers made of this special silk fabric but only one of each pair was coated with AEGIS AEM 5572/5. Microbiological examinations were done with standard cultural swabs and by means of quantification of bacterial agents using agar plates at baseline, after 1 h and after 7 days.
  
  
  RESULTS
  After 7 days a significant improvement in the mean value of the 'local SCORAD' index was observed in both the covered areas compared to the values obtained at baseline. The reduction in the mean number of colony forming units per square centimetre was similar in both areas.
  
  
  CONCLUSIONS
  Although this special silk fabric seems to be able to improve skin lesions in AD, we were unable to demonstrate that such silk fabrics coated with AEGIS AEM 5572/5 have an antibacterial activity in vivo, as shown in vitro.
authors.affiliation: Department of Pediatrics, University of Bologna, Bologna, Italy. ricci@med.unibo.it
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Ricci
authors.forename: Annalisa
authors.initials: A
authors.lastname: Patrizi
authors.forename: Paolo
authors.initials: P
authors.lastname: Mandrioli
authors.forename: Fernando
authors.initials: F
authors.lastname: Specchia
authors.forename: Matelda
authors.initials: M
authors.lastname: Medri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Menna
authors.forename: Massimo
authors.initials: M
authors.lastname: Masi
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003020:Clothing; D015169:Colony Count, Microbial; D003876:Dermatitis, Atopic / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008826:Microbial Sensitivity Tests; D047011:Silk; D013207:Staphylococcal Skin Infections / Q000209:etiology / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013784:Textiles; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D047011:Silk