title: Infants fed docosahexaenoic acid- and arachidonic acid-supplemented formula have decreased incidence of bronchiolitis/bronchitis the first year of life.
abstract: To assess the effect of docosahexaenoic acid and arachidonic acid supplementation in infant formula on the incidence of respiratory illnesses, pediatricians assigned infants to receive docosahexaenoic acid/arachidonic acid-supplemented formula or control formula. Anthropometrics, medical history, and illnesses were reported. Among 1342 infants, there was a higher incidence of bronchiolitis in control versus docosahexaenoic acid/arachidonic acid-supplemented groups at 5, 7, and 9 months (P < .01). Weight, length, and head circumference were similar for both groups. Infants fed formula supplemented with 0.32% docosahexaenoic acid and 0.64% arachidonic acid experienced a lower incidence of bronchiolitis compared with infants fed formula supplemented with no docosahexaenoic acid/arachidonic acid or lower levels of docosahexaenoic acid/arachidonic acid in the first year of life.
authors.affiliation: Mead Johnson Nutritionals, USA.
authors.forename: Nitida
authors.initials: N
authors.lastname: Pastor
authors.forename: Begoña
authors.initials: B
authors.lastname: Soler
authors.forename: Susan Hazels
authors.initials: SH
authors.lastname: Mitmesser
authors.forename: Paul
authors.initials: P
authors.lastname: Ferguson
authors.forename: Carlos
authors.initials: C
authors.lastname: Lifschitz
mesh_terms: D000886:Anthropometry; D016718:Arachidonic Acid / Q000008:administration & dosage*; D001988:Bronchiolitis / Q000453:epidemiology / Q000517:prevention & control; D001991:Bronchitis / Q000453:epidemiology* / Q000517:prevention & control*; D015986:Confounding Factors, Epidemiologic; D018849:Controlled Clinical Trials as Topic; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D041943:Infant Formula; D008297:Male; D011446:Prospective Studies; D012220:Rhinitis / Q000453:epidemiology / Q000517:prevention & control; D013030:Spain / Q000453:epidemiology; D013997:Time Factors
chemical_list: D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid