Holmes tremor: Application of modern neuroimaging techniques.
Holmes tremor has a characteristic rest, intention, and postural component. The syndrome arises as a consequence of a lesion in the upper brainstem and cerebral peduncles, which, it is postulated, interrupts the cerebello-rubrothalamic pathway. Ataxia, ophthalmoplegia, and bradykinesia are associated features. We present a case of Holmes tremor secondary to a midbrain cavernoma. Modern neuroimaging techniques in this case confirm that a combination of damage to the cerebello-rubrothalamic pathway and the nigrostriatal pathway is required for the full Holmes tremor syndrome to occur.
Paviour
Dominic C
DC
The Sara Koe PSP Research Centre, The Institute of Neurology, UCL, London, United Kingdom. dpaviour@dementia.ion.ucl.ac.uk
Jäger
H Rolf
HR
Wilkinson
Leonora
L
Jahanshahi
Marjan
M
Lees
Andrew J
AJ
D000328:Adult; D001921:Brain / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D014202:Tremor / Q000175:diagnosis*