A pediatric patient with neuro-Behçet's disease.
Behçet's disease is rare in childhood. We describe a 10-year-old boy with neuro-Behçet's disease (NB) who presented with fever, headache, vertigo, and hearing loss. An examination of the cerebrospinal fluid (CSF) revealed pleocytosis as well as elevated protein and interleukin (IL)-6 levels. Brain magnetic resonance imaging (MRI) showed hyperintensity of the right thalamus and midbrain on T2-WI, and gadolinium (Gd) enhancement of left acoustic nerve origin. HLA-B51 was positive. Prednisolone combined with methotrexate resulted in a complete remission. Brain MRI and the CSF IL-6 level were useful for the diagnosis and monitoring of this pediatric patient with NB.
Hatachi
Saori
S
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Nakazawa
Takashi
T
Morinobu
Akio
A
Kasagi
Shinpei
S
Kogata
Yoshinori
Y
Kageyama
Gohichi
G
Kawano
Seiji
S
Koshiba
Masahiro
M
Kumagai
Shunichi
S
D001528:Behcet Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000503:physiopathology; D001921:Brain / Q000473:pathology*; D002648:Child; D005334:Fever / Q000209:etiology; D015235:HLA-B Antigens / Q000235:genetics; D059949:HLA-B51 Antigen; D006261:Headache / Q000209:etiology; D034381:Hearing Loss / Q000209:etiology; D006801:Humans; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D008279:Magnetic Resonance Imaging; D008297:Male; D014717:Vertigo / Q000209:etiology
D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D015850:Interleukin-6