title: Lactic acid bacteria increase antiallergic effect of Artemisia princeps pampanini SS-1.
abstract: Artemisia princeps Pampanini, which is called Ssajuarissuk in Korean (SS-1), was fermented with lactic acid bacteria (LAB) and their passive cutaneous anaphylaxis reaction-inhibitory activity was investigated. Of these fermented agents, SS-1 extract fermented with Bifidobacterium infantis K-525 (F-SS-1) most effectively inhibited the release of P-hexosamindase from RBL-2H3 cells induced IgE. In IgE-induced RBL-2H3 cells, F-SS-1 inhibited proinflammatory cytokines IL-6 and TNF-alpha mRNA expression. Oral administration of SS-1 and F-SS-1 to mice inhibited passive cutaneous anaphylaxis (PCA) reaction induced by IgE and scratching behaviors induced by compound 48/80. The inhibitory activity of F-SS-1 against scratching behaviors was more effective than that of SS-1. These findings suggest that the fermentation of SS-1 with LAB can increase its antiallergic activity.
authors.affiliation: College of Pharmacy, Kyung Hee University, Dongdaemun-ku, Seoul 130-701, Korea.
authors.forename: Seung-Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: Yong-Wook
authors.initials: YW
authors.lastname: Shin
authors.forename: Eun-Ah
authors.initials: EA
authors.lastname: Bae
authors.forename: Bomi
authors.initials: B
authors.lastname: Lee
authors.forename: Sungwon
authors.initials: S
authors.lastname: Min
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Hae-Gon
authors.initials: HG
authors.lastname: Chung
authors.forename: Nam-Jae
authors.initials: NJ
authors.lastname: Kim
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D019306:Artemisia / Q000737:chemistry*; D001419:Bacteria / Q000378:metabolism*; D002460:Cell Line; D005243:Feces / Q000382:microbiology; D005260:Female; D005285:Fermentation; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis; D010936:Plant Extracts / Q000494:pharmacology; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000009:adverse effects
chemical_list: D018926:Anti-Allergic Agents; D010936:Plant Extracts; D019344:Lactic Acid; D003189:p-Methoxy-N-methylphenethylamine; D001619:beta-N-Acetylhexosaminidases