Highly enantioselective alpha-aminoxylation of aldehydes and ketones in ionic liquids.
As the first example for the synthesis of optically active alpha-hydroxyaldehydes and alpha-hydroxyketones in ionic liquids, we applied RTILs into L-proline catalyzed direct enantioselective alpha-aminoxylation of both aldehydes and ketones successfully. This protocol features a number of advantages, such as recycling of green solvents and chiral organocatalyst, high yields, excellent enantioselectivities, short reaction times, and broad substrate scope.
Huang
Kun
K
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
Huang
Zhi-Zhen
ZZ
Li
Xin-Liang
XL