[Chemical modification of heparin].
Heparin was modified at carboxyl groups by reaction with several pharmacologically important amino-containing compounds in aqueous medium in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide. In dependence on the nature of the amine and the ratio of reagents, conjugates containing 36-100% amide and 0-25% isoureidocarbonyl groups were synthesized. Isoureidoarylamide groups are present, along with amide moieties, in the products of heparin modification by hydroxyl-containing aromatic amines. The conjugate of heparin with p-aminobenzoic acid contained oligomeric arylamide.
Ponedel'kina
I Iu
IIu
Odinokova
V N
VN
Lukina
E S
ES
Tiumkina
T V
TV
Khalilov
L M
LM
Dzhemilev
U M
UM
D000588:Amines / Q000737:chemistry; D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D005022:Ethyldimethylaminopropyl Carbodiimide / Q000031:analogs & derivatives / Q000737:chemistry; D006493:Heparin / Q000031:analogs & derivatives* / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000588:Amines; D020533:Angiogenesis Inhibitors; D012996:Solutions; D014867:Water; C041829:1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide methiodide; D006493:Heparin; D005022:Ethyldimethylaminopropyl Carbodiimide