Wet powder processing of sol-gel derived mesoporous silica-hydroxyapatite hybrid powders.
This paper describes a method by which a porous silica coating layer can be obtained on different apatite particles through a simple sol-gel synthesis route. Sol-gel derived powders of hydroxyapatite (HAP) and beta tricalciumphosphate (beta-TCP) were coated with a mesoporous silica using C16TAB (hexadecyltrimethylammonium bromide) as a template in order to induce mesophase formation. Further calcination of the material removes the template from the mesophase and leaves a highly ordered hexagonal arranged mesoporous silica structure with a core of HAP/beta-TCP. The phase purity of the SiO2/apatite composites has been thoroughly investigated by the means of FT-IR, XRD, and solid state 31P MAS NMR. The phase purity of these materials is shown to be dependent on the solubility properties of the used apatites. The hybrid materials are suitable as a multifunctional biomaterial where osteoconductive properties can be combined with drug delivery.
Andersson
Jenny
J
Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3-5, FIN-20500 Turku, Finland.
Johannessen
Espen
E
Areva
Sami
S
Järn
Mikael
M
Lindén
Mika
M
D001031:Apatites / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005782:Gels; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016011:Normal Distribution; D044367:Phase Transition; D011208:Powders; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014961:X-Ray Diffraction / Q000379:methods
D001031:Apatites; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D005782:Gels; D011208:Powders; C485817:beta-tricalcium phosphate; D012822:Silicon Dioxide; D017886:Durapatite