[Experiment of using distraction osteogenesis to repair skull defect].
OBJECTIVE
To explore the possibility of using distraction osteogenesis to repair skull defect.


METHODS
17 goats with one year age were chosen randomly. The animals were divided to 3 groups. Group A includes 7 goats, a 3.0 cm x 2.2 cm rectangle skull defect is created on both sides of parietal area. Group B includes 5 goats, a 2.2 cm x 2.2 cm square skull defect was created on right side of parietal area. Group C includes 5 goats, a 3 cm x 1 cm rectangle skull defect was created on both sides of parietal area. Accordingly, different size of transport discs were created on right side of skull and the distraction apparatus is implanted. 3-D CT was done to measure the skull defect on group A. Biomechanical test was done on group B. Process of bone formation illustrated by histological stain, scan and transparent electric microscope was observed on group C.


RESULTS
Group A measured by 3-D CT showed that skull defect of experimental side have been repaired by distraction osteogenesis. There was definitely difference between experimental and control side (P < 0.01). Group B measured by biomechanical test showed no definitely difference between experimental and normal side (maximum load P = 0.235 > 0.05, rigidity P = 0.213 > 0.05). Group C showed that the process of bone formation was typical intramembranous.


CONCLUSIONS
The evidence showed that skull defect of goat can be repaired by distraction osteogenesis.
Yu
Bing
B
Department of Cranio Maxillo Facial Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Gui
Lai
L
Zhang
Zhi-Yong
ZY
Teng
Li
L
Lü
Chang-Sheng
CS
Niu
Feng
F
Jin
Ji
J
Huang
Lü-Ping
LP
D000818:Animals; D006041:Goats; D019857:Osteogenesis, Distraction; D012886:Skull / Q000473:pathology / Q000601:surgery*