title: Deiodinases: implications of the local control of thyroid hormone action.
abstract: The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein-coupled bile acid receptor 1-mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.
authors.affiliation: Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. abianco@partners.org
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Bianco
authors.forename: Brian W
authors.initials: BW
authors.lastname: Kim
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007453:Iodide Peroxidase / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D015398:Signal Transduction / Q000502:physiology; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D013963:Thyroid Hormones; D007453:Iodide Peroxidase