title: Pluripotent human stem cells as novel tools in drug discovery and toxicity testing.
abstract: Improved technologies are urgently needed to develop effective and safe new drugs in a cost-efficient manner. Cell-based assays have many advantages in drug research, particularly because these assays can be adapted in a high-throughput format. In addition, technological advances in the areas of instrumentation and automation are providing expanding opportunities for high-content analyses. However, in cell-based research, none of these systems is particularly useful unless the cells that are being evaluated are clinically relevant. Pluripotent human stem cells are expected to revolutionize the accessibility to a variety of human cell types. The possibility to propagate pluripotent human stem cells and to subsequently differentiate these cells into desired target cell types will provide a stable supply of cells for a range of applications in drug discovery and toxicity testing. This feature discusses some of the research opportunities for pluripotent human stem cells.
authors.affiliation: Cellartis AB, Arvid Wallgrens Backe 20, 413 46 Göteborg, Sweden. peter.sartipy@cellartis.com
authors.forename: Peter
authors.initials: P
authors.lastname: Sartipy
authors.forename: Petter
authors.initials: P
authors.lastname: Bjorquist
authors.forename: Raimund
authors.initials: R
authors.lastname: Strehl
authors.forename: Johan
authors.initials: J
authors.lastname: Hyllner
mesh_terms: D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000187:drug effects*; D018675:Toxicity Tests / Q000379:methods*