A short water-soluble self-assembling peptide forms amyloid-like fibrils.
A water-soluble tripeptide Val-Ile-Ala (VIA) , bearing sequence identity with the C-terminal portion of the Alzheimer Abeta-peptide (Abeta(40-42)), self-assembles, in crystalline form, to produce an intermolecularly hydrogen bonded supramolecular beta-sheet structure which self-associates to form straight, unbranched nanofibrils exhibiting amyloid-like behavior; in contrast, the synthetic tripeptide Ala-Val-Ile (AVI) self-assembles to produce a beta-sheet structure that forms branched nanofibrils which do not show any characteristic features of amyloid-like fibrils.
Ray
Sudipta
S
Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India.
Das
Apurba K
AK
Drew
Michael G B
MG
Banerjee
Arindam
A