A biocompatible method of decorporation: bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood.
We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.
Wang
Ling
L
Departments of Chemistry and Physics, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
Yang
Zhimou
Z
Gao
Jinhao
J
Xu
Keming
K
Gu
Hongwei
H
Zhang
Bei
B
Zhang
Xixiang
X
Xu
Bing
B
D001672:Biocompatible Materials / Q000737:chemistry*; D004164:Diphosphonates / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013050:Spectrometry, Fluorescence; D014501:Uranium / Q000097:blood / Q000302:isolation & purification*
D001672:Biocompatible Materials; D004164:Diphosphonates; D014501:Uranium; D052203:Ferrosoferric Oxide