G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke.
The human lectin-like oxidized low-density lipoprotein receptor 1 (OLR1/LOX-1) is the major endothelial scavenger receptor against oxidized low-density lipoprotein (Ox-LDL), which has been implicated in the pathogenesis of atherosclerosis. We investigated the G501C mutation in the OLR1 gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 274 age- and sex-matched healthy controls using single nucleotide primer extension analysis (SNuPe). There was no significant difference in the polymorphism between patients with ischemic CVD and controls (GC+CC versus GG, p=0.48). The C allele was not significantly different between the patients and controls (C versus G, p=0.91). Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.
Hattori
Hidenori
H
Department of Neurology, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan. hidehatt@1999.jukuin.keio.ac.jp
Sonoda
Akira
A
Sato
Hideki
H
Ito
Daisuke
D
Tanahashi
Norio
N
Murata
Mitsuru
M
Saito
Ikuo
I
Watanabe
Kiyoaki
K
Suzuki
Norihiro
N
D002545:Brain Ischemia / Q000235:genetics*; D006801:Humans; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051127:Scavenger Receptors, Class E / Q000235:genetics*; D020521:Stroke / Q000235:genetics*
C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E