[Induction of micronuclei in somatic cells of mice exposed to x-rays or nonylphenol and to a combination of both agents].
The effects of X-rays, nonylphenol (NL) and combination of both agents on the induction of micronuclei in mouse somatic cells were investigated. Pzh: SFIS mice were exposed during 2 weeks, 5 days per week to X-rays (doses: 0.05 Gy, 0.10 Gy,0.20 Gy), nonylphenol (doses: 25 mg/kg bw NL, 50 mg/kg bw NL, 100 mg/kg bw NL) and to a combination of X-rays and nonylphenol (doses: 0.05 Gy + 25 mg/kg bw NL, 0.10 Gy + 50 mg/kg bw NL). Samples from peripheral blood were taken 1 week after the start of exposure and 24 h after the end of exposure, whereas samples from bone marrow were taken 24 h after the end of exposure. Results obtained show that ionizing radiation, nonylphenol and combination of X-rays-NL in low doses induced micronuclei in peripheral blood and bone marrow reticulocytes. In contrast combined exposure to higher doses of both agents caused reduction frequency of micronuclei in the comparison to effects of X-rays acting alone. In bone marrow polychromatic erythrocytes the induction of micronuclei was enhanced after combined exposure to both agents in lower and higher doses.
Czajka
Urszula
U
Zakład Ochrony Radiologicznej i Radiobiologii Państwowy Zakład Higieny 00-791 Warszawa, ul. Chocimska 24. uczajka@pzh.gov.pl
Dobrzyńska
Małgorzata M
MM
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000187:drug effects* / Q000528:radiation effects*; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000008:administration & dosage / Q000009:adverse effects / Q000528:radiation effects; D010636:Phenols / Q000633:toxicity*; D013997:Time Factors; D014916:Whole-Body Irradiation; D014965:X-Rays / Q000009:adverse effects*
D009153:Mutagens; D010636:Phenols; C025256:nonylphenol