[Clinicopathologic manifestation of amiodarone-induced lung injury].
OBJECTIVE
To study the clinical, pathologic and radiologic features of amiodarone-induced lung injury.


METHODS
The clinical, pathologic and radiologic features, including treatment and follow-up information of three cases diagnosed as amiodarone-induced lung injury from October 2004 to October 2005 in the Peking Union Medical College Hospital were reviewed.


RESULTS
All the patients were males, with age ranging from 35 to 64 years. The duration of symptoms varied from 20 days to 3 years. All presented with cough. Worsening dyspnea and inspiratory crackles were noted in two patients. Computerized tomography showed bilateral patchy infiltration, ground-glass appearance and accentuation of bronchovascular markings. The most common pathologic manifestations included cellular interstitial pneumonia associated with intra-alveolar collections of macrophages and type II pneumocyte hyperplasia. Some of the macrophages contained finely vacuolated cytoplasm. An organizing pneumonia pattern was seen in one patient.


CONCLUSIONS
Amiodarone-induced lung injury has characteristic pathologic features which may provide clues to diagnosis. Correlation with clinical and radiologic findings is also important.
Shi
Ju-hong
JH
Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.
Liu
Hong-rui
HR
Zhu
Yuan-jue
YJ
Xu
Wen-bing
WB
D000328:Adult; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D001706:Biopsy; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D055370:Lung Injury / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
D000889:Anti-Arrhythmia Agents; D005938:Glucocorticoids; D000638:Amiodarone; D011241:Prednisone