title: Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese.
abstract: To investigate the association between polymorphisms in the G protein-coupled receptor kinase 4 gene (GRK4) (R65L, A142V and A486V) and essential hypertension in northern Han Chinese, we conducted a case-control study consisting of 503 individuals with essential hypertension (HT) and 490 age-, gender-, and area-matched normotensive (NT) controls. The three GRK4 variants were genotyped by PCR-RFLP analysis. Both haplotype and single locus analysis were used to process the genotyping data. The A486 allele showed a significant association with HT (P < 0.001). A total of 6 haplotypes were observed in the entire population, with the haplotypes L-V-A and R-A-A being found to be significantly related to hypertension (P= 0.001).
authors.affiliation: Division of Population Genetics and Prevention, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Wang
authors.forename: Biao
authors.initials: B
authors.lastname: Li
authors.forename: Weiyan
authors.initials: W
authors.lastname: Zhao
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.forename: Shufeng
authors.initials: S
authors.lastname: Chen
authors.forename: Hongfan
authors.initials: H
authors.lastname: Li
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D054771:G-Protein-Coupled Receptor Kinase 4; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: D017346:Protein Serine-Threonine Kinases; D054771:G-Protein-Coupled Receptor Kinase 4; C517855:GRK4 protein, human