Melanoma chemoprevention.
BACKGROUND
Despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. The prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures.


OBJECTIVE
We sought to summarize the results of published research on candidate chemoprevention agents for melanoma.


METHODS
We conducted a narrative review of the literature.


RESULTS
Investigation into a possible role in melanoma chemoprevention continues for multiple agents, including sunscreen, lipid-lowering medications, nonsteroidal anti-inflammatory drugs, dietary nutrients, immunomodulators, and other drugs, including retinoids, difluoromethylornithine, and T4 endonuclease V.


CONCLUSIONS
Systematic review of the literature was not performed.


CONCLUSIONS
Because no agent yet emerges as a clear choice for effective melanoma chemoprevention, sun avoidance and sun protection remain the mainstay of melanoma prevention for persons at high risk.
Francis
Shayla O
SO
Department of Dermatology, University of Colorado Health Sciences Center, Aurora, Colorado, USA.
Mahlberg
Matthew J
MJ
Johnson
Kathryn R
KR
Ming
Michael E
ME
Dellavalle
Robert P
RP
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D018890:Chemoprevention; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008545:Melanoma / Q000517:prevention & control*; D044623:Nutrition Therapy; D012878:Skin Neoplasms / Q000517:prevention & control*; D013473:Sunscreening Agents / Q000627:therapeutic use; D014612:Vaccines / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000960:Hypolipidemic Agents; D007155:Immunologic Factors; D013473:Sunscreening Agents; D014612:Vaccines