Synthesis and antifungal activity of 1H-indole-4,7-diones.
1H-Indole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. The synthesized 1H-indole-4,7-diones generally showed good antifungal activity against Candida krusei, Cryptococcus neoformans, and Aspergillus niger. The results suggest that 1H-indole-4,7-diones would be potent antifungal agents.
Ryu
Chung-Kyu
CK
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@mm.ewha.ac.kr
Lee
Jung Yoon
JY
Park
Rae-Eun
RE
Ma
Mi-Young
MY
Nho
Ji-Hee
JH
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003904:Mitosporic Fungi / Q000187:drug effects*
D000935:Antifungal Agents; D007211:Indoles