Primate area MST-l is involved in the generation of goal-directed eye and hand movements.
The contributions of the middle superior temporal area (MST) in the posterior parietal cortex of rhesus monkeys to the generation of smooth-pursuit eye movements as well as the contributions to motion perception are well established. Here, we present the first experimental evidence that this area also contributes to the generation of goal-directed hand movements toward a moving target. This evidence is based on the outcome of intracortical microstimulation experiments and transient lesions by small injections of muscimol at identified sites within the lateral part of area MST (MST-l). When microstimulation was applied during the execution of smooth-pursuit eye movements, postsaccadic eye velocity in the direction of the preferred direction of the stimulated site increased significantly (in 93 of 136 sites tested). When microstimulation was applied during a hand movement trial, the hand movement was displaced significantly in the same direction (in 28 of 39 sites tested). When we lesioned area MST-l transiently by injections of muscimol, steady-state eye velocity was exclusively reduced for ipsiversive smooth-pursuit eye movements. In contrast, hand movements were displaced toward the contralateral side, irrespective of the direction of the moving target. Our results provide evidence that area MST-l is involved in the processing of moving targets and plays a role in the execution of smooth-pursuit eye movements as well as visually guided hand movements.
Ilg
Uwe J
UJ
Cognitive Neurology, Hertie-Institute of Clinical Brain Research, University of Tübingen, Otfried-Müller Strasse 27, D 72076 Tübingen, Germany. uwe.ilg@uni-tuebingen.de
Schumann
Stefan
S
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001288:Attention / Q000502:physiology; D004558:Electric Stimulation; D018755:GABA Agonists / Q000494:pharmacology; D006225:Hand / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D009039:Motion Perception / Q000187:drug effects / Q000502:physiology*; D009068:Movement / Q000187:drug effects / Q000502:physiology; D009118:Muscimol / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009483:Neuropsychological Tests; D009949:Orientation / Q000187:drug effects / Q000502:physiology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D011698:Pursuit, Smooth / Q000187:drug effects / Q000502:physiology*; D013028:Space Perception / Q000187:drug effects / Q000502:physiology; D013702:Temporal Lobe / Q000187:drug effects / Q000502:physiology*; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology*; D014795:Visual Pathways / Q000187:drug effects
D018755:GABA Agonists; D009118:Muscimol