title: Bisphosphonates prevent experimental vascular calcification: Treat the bone to cure the vessels?
abstract: Bisphosphonates are inhibitors of bone resorption that are widely used to treat osteoporosis. Price and colleagues demonstrate that ibandronate suppressed the development of uremia-related vascular calcification in rats. These findings extend the link between bone remodeling and vascular calcification to the context of chronic renal failure, opening perspectives toward novel therapeutic strategies.
authors.affiliation: Department of Pathophysiology, University of Antwerp, Antwerp, Belgium. veerle.persy@ua.ac.be
authors.forename: V
authors.initials: V
authors.lastname: Persy
authors.forename: M
authors.initials: M
authors.lastname: De Broe
authors.forename: M
authors.initials: M
authors.lastname: Ketteler
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001851:Bone Diseases, Metabolic / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D001862:Bone Resorption / Q000188:drug therapy / Q000503:physiopathology; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002114:Calcinosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D004164:Diphosphonates / Q000494:pharmacology* / Q000627:therapeutic use; D000077557:Ibandronic Acid; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000503:physiopathology; D051379:Mice; D051381:Rats; D014652:Vascular Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077557:Ibandronic Acid