Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as new rubella virus inhibitors.
In the search for new chemotherapeutic agents useful against Rubella virus (RV) infections, a solution-phase parallel approach for the synthesis of a small library of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines has been set up, based on previous results from our research group. Biological evaluation of the newly synthesized compounds pointed out their interesting properties as anti-RV agents with IC(50) values in the micromolar range.
Mugnaini
Claudia
C
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Siena, Italy.
Petricci
Elena
E
Botta
Maurizio
M
Corelli
Federico
F
Mastromarino
Paola
P
Giorgi
Gianluca
G
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002522:Chlorocebus aethiops; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012412:Rubella virus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000998:Antiviral Agents; D011743:Pyrimidines