Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women.
We studied the association between herpes simplex virus type-2 (HSV-2) and HIV-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. Forty-seven (68%) men and 57 (80%) women were HSV-2 antibody positive, of whom 12 (26%, 95% confidence interval [CI] 20, 32) and five (8%, 95% CI 4, 12), respectively, had HSV-2 genital shedding detected by polymerase chain reaction. The mean HIV-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence of HSV-2 shedding. Eleven men and 15 women presented with genital ulcers; all ulcers were due to HSV-2. Ten men and nine women were followed up over six days: the mean (95% CI) HIV-1 log viral load copies/mL in the genital ulcers at baseline and final visits were 2.5 (2.3, 2.7) and 3.1 (2.0, 4.2) for men and 3.0 (2.6, 3.4) and 2.7 (2.3, 3.1) for women. These findings do not support the hypothesis that HSV-2 increases the HIV-1 viral load in genital secretions.
Chu
Kathryn
K
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Jiamton
Sukhum
S
Pepin
Jacques
J
Cowan
Frances
F
Mahakkanukrauh
Bussakorn
B
Suttent
Ruengpung
R
Robinson
Noah J
NJ
Deslandes
Sylvie
S
Frost
Eric
E
Chaisilwattana
Pongsakdi
P
Suthipinittharm
Puan
P
Grosskurth
Heiner
H
Brown
David
D
Jaffar
Shabbar
S
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002353:Carrier State / Q000097:blood / Q000473:pathology / Q000821:virology; D002584:Cervix Uteri / Q000378:metabolism / Q000821:virology*; D004198:Disease Susceptibility / Q000209:etiology / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000209:etiology* / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006558:Herpes Genitalis / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000821:virology; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006786:Hospitals, Urban; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012661:Semen / Q000821:virology*; D013785:Thailand; D014456:Ulcer / Q000473:pathology / Q000821:virology; D014621:Vagina / Q000378:metabolism / Q000821:virology*; D019562:Viral Load; D014777:Virus Diseases / Q000235:genetics
D000914:Antibodies, Viral