title: Prevalence and antimicrobial susceptibility patterns of Shigella species in Asmara, Eritrea, northeast Africa.
abstract: OBJECTIVE
  Diarrheal diseases are an important cause of morbidity and mortality in children in developing countries. Of the bacterial causes of dysentery, Shigella are the major enteropathogens with outbreak potential and common development of antimicrobial resistance. This study determined the prevalence and antimicrobial susceptibility patterns of different spp. of Shigella in Asmara, Eritrea.
  
  
  METHODS
  Diarrheic stool specimens of a total of 2,420 children were screened for Shigella organisms over a period of 3 years using standard methods. The Shigella isolates were tested for antimicrobial susceptibility pattern by the disk diffusion method.
  
  
  RESULTS
  Of the 84 Shigella isolates, 54 were Shigella flexneri and 20 were Shigella dysenteriae type 1. High rates of resistance were observed against ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole; 6% of the S. flexneri isolates were resistant to nalidixic acid.
  
  
  CONCLUSIONS
  The study emphasizes the need for continuous monitoring of the occurrence of Shigella organisms and their antimicrobial susceptibility pattern for the successful treatment and control of Shigella dysentery, and also for the development of public health policy for populations at risk for shigellosis.
authors.affiliation: Department of Clinical Laboratory Science, College of Health Science, University of Asmara, Asmara, Eritrea. durga_das2002@yahoo.com
authors.forename: Durgadas Govind
authors.initials: DG
authors.lastname: Naik
mesh_terms: D000293:Adolescent; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000494:pharmacology; D004405:Dysentery, Bacillary / Q000382:microbiology*; D019017:Eritrea; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012760:Shigella / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D013045:Species Specificity; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination