title: Aspirin and decreased adult-onset asthma: randomized comparisons from the physicians' health study.
abstract: BACKGROUND
  In an observational cohort study, women who self-selected for frequent aspirin use developed less newly diagnosed asthma than women who did not take aspirin.
  
  
  OBJECTIVE
  To explore whether low-dose aspirin decreased the risk of newly diagnosed asthma in a randomized, double-blind, placebo-controlled trial.
  
  
  METHODS
  The Physicians' Health Study randomized 22,071 apparently healthy male physicians, aged 40-84 yr at baseline and tolerant of aspirin, over an 18-wk run-in period, to 325 mg aspirin or placebo on alternate days. The aspirin component was terminated after 4.9 yr due principally to the emergence of a statistically extreme 44% reduction in risk of first myocardial infarction among those randomly assigned to aspirin.
  
  
  METHODS
  Physicians could self-report an asthma diagnosis on questionnaires at baseline, 6 mo, and annually thereafter. Asthma was not an a priori endpoint of the trial.
  
  
  RESULTS
  Among 22,040 physicians without reported asthma at randomization, there were 113 new asthma diagnoses in the aspirin group and 145 in the placebo group. The hazard ratio was 0.78 (95% confidence interval, 0.61-1.00; p = 0.045). This apparent 22% lower risk of newly diagnosed asthma among those assigned to aspirin was not modified by baseline characteristics including smoking, body mass index, or age.
  
  
  CONCLUSIONS
  Aspirin reduced the risk of newly diagnosed adult-onset asthma in a large, randomized clinical trial of apparently healthy, aspirin-tolerant men. This result requires replication in randomized trials designed a priori to test this hypothesis; it does not imply that aspirin improves symptoms in patients with asthma.
authors.affiliation: Division of General Medicine, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.forename: Tobias
authors.initials: T
authors.lastname: Kurth
authors.forename: Meir J
authors.initials: MJ
authors.lastname: Stampfer
authors.forename: Julie E
authors.initials: JE
authors.lastname: Buring
authors.forename: Charles H
authors.initials: CH
authors.lastname: Hennekens
authors.forename: J Michael
authors.initials: JM
authors.lastname: Gaziano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage*; D001249:Asthma / Q000175:diagnosis* / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010820:Physicians; D012306:Risk; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology
chemical_list: D001241:Aspirin