Improving foldamer synthesis through protecting group induced unfolding of aromatic oligoamides.
The hydrogen bond rigidified backbones of aromatic oligoamides are temporarily interrupted by replacing the amide hydrogens with the acid-labile 2,4-dimethoxybenzyl (DMB) group, which allows the efficient preparation of long folding oligomers that, upon removal of the DMB groups, fold into multiturn helices. [structure: see text]
Zhang
Aimin
A
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Ferguson
Joseph S
JS
Yamato
Kazuhiro
K
Zheng
Chong
C
Gong
Bing
B