Pericytes may have an important role in the pathogenesis of vascular malformations.
Vascular malformations are a series of congenital developmental abnormalities. The defects in vascular remodeling may contribute to the formation of these unique entities. Pericytes are the component of microvascular system and play a key role in vascular remodeling. It is logical to propose pericytes may play an important role in the pathogenesis of vascular malformations. Target therapies against pericytes probably bring new sight into vascular malformations treatment.
Li
Chen
C
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 237# Luo Yu Road, Wuhan 430079, PR China.
Zhang
Wen-Feng
WF
Zhao
Yi-Fang
YF
D000818:Animals; D018376:Cardiovascular Abnormalities / Q000473:pathology*; D049109:Cell Proliferation; D000013:Congenital Abnormalities; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D008833:Microcirculation; D008954:Models, Biological; D020286:Pericytes / Q000166:cytology*; D015398:Signal Transduction; D014652:Vascular Diseases / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A