title: Pharmacological evaluation of Pachyrrhizus erosus (L) seeds for central nervous system depressant activity.
abstract: The research work deals with the screening of ethanol and chloroform extracts of Pachyrrhizus erosus seeds for central nervous system (CNS) depressant activity. The Pachyrrhizus erosus seed is known to contain rotinoids, flavonoids and phenylfuranocoumarin derivatives as chemical components and is reported to have antifungal, antisecretory, insecticides, antibacterial and spasmolytic activity. Since seeds of Pachyrrhizus erosus is used as folk medicine in treatment of insomnia, we made an attempt to study its CNS depressant effect. The different activities studied were potentiation of pentobarbitone-induced sleep, test for locomotor activity, effect on muscle co-ordination, antiaggressive and antianxiety activities. The result of the study reflected that ethanol extract of the seeds (150 mg/kg, p.o) decreased locomotor activity, produced muscle relaxation and showed antianxiety and antiaggressive activity.
authors.affiliation: Krupanidhi College of Pharmacy, #5, Sarjapur Road, Koramangala, Bangalore 560 034.
authors.forename: Mohd
authors.initials: M
authors.lastname: Abid
authors.forename: H J
authors.initials: HJ
authors.lastname: Hrishikeshavan
authors.forename: Mohammed
authors.initials: M
authors.lastname: Asad
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D029905:Pachyrhizus / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*
chemical_list: D014151:Anti-Anxiety Agents; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D010936:Plant Extracts