Synthesis and antioxidant evaluation of novel silybin analogues.
In this work, we evaluated the antioxidant properties of the eight novel silybin analogues for their capacity to scavenge free radicals including superoxide anion radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in vitro. Compound 7d demonstrated an excellent antioxidant effect in scavenging superoxide anion free radical with an IC50 value of 26.5 microM, while the IC50 of quercetin (the reference compound) was 38.1 microM. Compounds 7b, 7e, 7h showed certain scavenging activities for both types of free radicals.
Yang
Leixiang
L
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 353 Yan an Road, Hangzhou 310031, PR China.
Gong
Jingxu
J
Wang
Feng
F
Zhang
Yongmin
Y
Wang
Yanguang
Y
Hao
Xiaojiang
X
Wu
Xiumei
X
Bai
Hua
H
Stöckigt
Joachim
J
Zhao
Yu
Y
D000838:Anions; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D010851:Picrates; D011794:Quercetin / Q000737:chemistry*; D000077385:Silybin; D012838:Silymarin / Q000737:chemistry; D013053:Spectrophotometry; D013481:Superoxides / Q000737:chemistry
D000838:Anions; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; D012838:Silymarin; D013481:Superoxides; D000077385:Silybin; D011794:Quercetin; C004931:1,1-diphenyl-2-picrylhydrazyl