Cannabinoids and PPARalpha signalling.
Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties, which were proposed to occur mainly via activation of the G-protein-coupled receptor CB(1) (cannabinoid receptor 1). Recently, certain cannabinoids have been reported to be ligands for members of the nuclear receptor transcription factor superfamily known as PPARs (peroxisome-proliferator-activated receptors). This review summarizes the evidence for cannabinoid activation of PPARs and identifies a new intracellular target for cannabinoids as therapeutic agents for neuroprotective treatment.
Sun
Y
Y
School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, UK. stxys3@nottingham.ac.uk
Alexander
S P H
SP
Kendall
D A
DA
Bennett
A J
AJ
D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D008958:Models, Molecular; D008959:Models, Neurological; D047493:PPAR alpha / Q000502:physiology*; D012319:RNA Polymerase II / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D002186:Cannabinoids; D047493:PPAR alpha; D012319:RNA Polymerase II