title: Malabsorption in psoriatic patients: cause or consequence?
abstract: OBJECTIVE
  The etiopathogenesis of psoriasis is still unclear. Associations between gut and skin diseases are well known, since psoriatic patients show a high prevalence of coeliac disease. Small-bowel abnormalities can cause clinical or, more frequently, laboratory alterations that give rise to malabsorption. The aim of the study was to evaluate the prevalence of malabsorption in psoriatic patients.
  
  
  METHODS
  Fifty-five (29 M, 26 F, mean age 51+/-8 years) psoriatic patients in the Dermatology Centre of our hospital and 65 healthy controls (36 M, 29 F, mean age 47+/-9 years) were screened for malabsorption using a D-xylose test. Psoriatic subjects who resulted positive were further investigated in order to reach a better characterization of the malabsorption using serum antigliadin, anti-endomysium and anti-transglutaminase antibodies, H2 lactulose breath test, the parasitological faecal test and colonoscopy with retrograde ileoscopy.
  
  
  RESULTS
  Altered D-xylose absorption was found in 60% (33/55) of psoriatic patients and in 3% (2/65) of controls. Of the former, 6% had coeliac disease, 21% had bacterial overgrowth, 3% had parasitic infections and 1 patient presented eosinophilic gastroenteritis.
  
  
  CONCLUSIONS
  Malabsorption was more prevalent among psoriatic patients than among controls. Coeliac disease, bacterial overgrowth, parasitic infestations and eosinophilic gastroenteritis could be possible causes of malabsorption in these patients. Further studies are needed to clarify the pathogenesis and possible causative associations between gut and skin diseases.
authors.affiliation: Department of Internal Medicine, Catholic University, Rome, Italy. veronica.ojetti@tin.it
authors.forename: Veronica
authors.initials: V
authors.lastname: Ojetti
authors.forename: Clara
authors.initials: C
authors.lastname: De Simone
authors.forename: Jose
authors.initials: J
authors.lastname: Aguilar Sanchez
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Capizzi
authors.forename: Alessio
authors.initials: A
authors.lastname: Migneco
authors.forename: Cristina
authors.initials: C
authors.lastname: Guerriero
authors.forename: Alessia
authors.initials: A
authors.lastname: Cazzato
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gasbarrini
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Amerio
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications; D005260:Female; D005756:Gastritis / Q000150:complications; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000150:complications; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011565:Psoriasis / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D012384:Rome / Q000453:epidemiology; D014994:Xylose
chemical_list: D014994:Xylose