Exiting the outside world for cross-presentation.
How are extracellular proteins cross-presented on MHC class I molecules? In this issue of Immunity, demonstrate that the ER-associated degradation (ERAD) export pathway operates in the phagosomes of dendritic cells and transfers antigens into the MHC class I pathway.
Rock
Kenneth L
KL
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
D017951:Antigen Presentation; D045142:Cross-Priming; D003713:Dendritic Cells / Q000276:immunology* / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D010588:Phagosomes / Q000378:metabolism*; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism
D015395:Histocompatibility Antigens Class I; D011506:Proteins