Increased serum inflammatory markers as predictors of airway obstruction.
Recruitment and activation of both neutrophils and eosinophils seem to be a characteristic of chronic bronchitis. The purpose of this study was to evaluate whether eosinophil cationic protein and/or myeloperoxidase (ECP/MPO) serum levels differ between patients with chronic obstructive and nonobstructive bronchitis during an exacerbation-free period and if they represent clinical gravity indicators of disease. To identify a correlation between ECP/MPO values in serum and bronco-obstruction, a statistical analysis by logistic regression was used. Study results show that there is a relationship between increased serum levels of ECP and log MPO and an increased risk for forced expiratory volume in 1 second (FEV1) pathologic values associated with obstructive chronic bronchitis, with an ECP odds ratio = 1.04 and logMPO = 4.45.
Amici
Mara De
MD
Department of Pediatrics, University of Pavia, IRCCS Policlinico S Matteo, Pavia, Italy. m.deamici@smatteo.pv.it
Moratti
Remigio
R
Quaglini
Silvana
S
Alesina
Roberta
R
Peona
Vittoria
V
D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000276:immunology; D001991:Bronchitis / Q000175:diagnosis* / Q000276:immunology; D029481:Bronchitis, Chronic / Q000175:diagnosis* / Q000276:immunology; D047150:Eosinophil Cationic Protein / Q000097:blood*; D004804:Eosinophils / Q000276:immunology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D016017:Odds Ratio; D009195:Peroxidase / Q000097:blood*; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000276:immunology; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D013223:Statistics as Topic
D018836:Inflammation Mediators; D009195:Peroxidase; D047150:Eosinophil Cationic Protein