title: [Evaluation of the sedation level with propofol with electroencephalographic Entropy in comparison with bispectral index monitor].
abstract: BACKGROUND
  Entropy, a newly available electroencephalographic monitor, demonstrates two parameters, response entropy (RE) and state entropy (SE). The aim of this study is to compare RE and SE with bispectral index (BIS) during anesthetic induction with propofol.
  
  
  METHODS
  Fifteen patients received target controlled infusion of propofol starting at 3 microg x ml(-1). We measured RE, SE and BIS and recorded effect-site concentrations of propofol at three sedation levels: VR1; conscious state before infusion of propofol, VR2; no response to verbal command, and VR3; no response to verbal command and shaking. Spearman rank correlations and prediction probability for sedation level were analyzed.
  
  
  RESULTS
  Effect-site concentrations of propofol at VR1, VR2, and VR3 were 0, 1.8 +/- 0.7, and 2.4 +/- 0.7, respectively. All three parameters showed significant correlations with sedation levels. Prediction probability values of SE, RE, and BIS were 0.905, 0.894, and 0.890, respectively.
  
  
  CONCLUSIONS
  Response entropy and SE can provide similar information as BIS about the sedation level with propofol.
authors.affiliation: Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551.
authors.forename: Hideki
authors.initials: H
authors.lastname: Fukuda
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kurita
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Osafumi
authors.initials: O
authors.lastname: Yuge
mesh_terms: D000328:Adult; D000368:Aged; D016292:Procedural Sedation; D004569:Electroencephalography / Q000379:methods*; D019277:Entropy; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol