title: Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae).
abstract: In our screening program for antihypertensive properties of plants, the leaves of Ailanthus excelsa (Roxb), a plant used in Egyptian traditional medicine, were analysed. Chromatographic separation of A. excelsa MeOH extract yielded six flavonoids for the first time from this species, namely apigenin, luteolin, kaempferol-3-O-alpha-arabinopyranoside, kaempferol-3-O-beta-galactopyranoside, quercetin-3-O-alpha-arabinopyranoside and luteolin-7-O-beta-glucopyranoside. The in vitro hypotensive activities of the MeOH extract and the isolated compounds were elucidated. All the flavonoids tested exhibited ACE inhibitory activity, in particular the most active compound was kaempferol-3-O-beta-galactopyranoside with an IC(50) value of 260 microm.
authors.affiliation: Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), Italy. mr.loizzo@unical.it
authors.forename: Monica Rosa
authors.initials: MR
authors.lastname: Loizzo
authors.forename: Ataa
authors.initials: A
authors.lastname: Said
authors.forename: Rosa
authors.initials: R
authors.lastname: Tundis
authors.forename: Khaled
authors.initials: K
authors.lastname: Rashed
authors.forename: Giancarlo Antonio
authors.initials: GA
authors.lastname: Statti
authors.forename: Antje
authors.initials: A
authors.lastname: Hufner
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
mesh_terms: D032268:Ailanthus; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D005419:Flavonoids; D010936:Plant Extracts; D007703:Peptidyl-Dipeptidase A