Suppression of life-threatening tachyarrhyhmias, and atrio-ventricular ischemic block following the administration of anti-inflammatory intravenous drug.
The occurrence of potentially lethal tachyarrhyhmias, or severe bradyarrhytmias could be the end of a cascade of pathophysiological abnormalities. These arrhythmias, occurring in the presence of a decompensated cardiopathy, can be inferred to have an inflammatory etiology. In the present study, we found that administration of an anti-inflammatory compound (ibuprofen IV) during the electrical storm resulted in an immediate suppression of the threatening arrhythmias.
Gurfinkel
Enrique P
EP
Guerlloy
Fernando P
FP
Mautner
Branco
B
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004630:Emergencies; D005260:Female; D006327:Heart Block / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000188:drug therapy*; D013610:Tachycardia / Q000188:drug therapy* / Q000209:etiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen