N-chlorotaurine--a new safe substance for postoperative ear care.
OBJECTIVE
The new endogenous substance N-chlorotaurine (NCT), which for the first time was synthesized and introduced into clinical practice by our research group, was now used for postoperative ear care following tympanoplasty. The antiseptic and drying effect of NCT was evaluated and compared to the standard postoperative procedure in our department.


METHODS
Prospective randomized trial on 10 patients. Local irrigations of the external auditory canal with 1% NCT solution were performed once daily until the canal was dry.


RESULTS
NCT was well tolerated. The external auditory canal showed no signs of infections and dried significantly more rapidly than the control group. In contrast to previous suppositions, epithelialization proceeded without complications and was identical in both groups.


CONCLUSIONS
As NCT in our first postoperative patient study was effective in preventing infections and drying of the outer ear canal was faster without impairing epithelialization, this agent seems useful for postoperative ear care.
Neher
Andreas
A
Department of Otorhinolaryngology, University Hospital of Innsbruck, Anichstr.35, Innsbruck, Austria. Andreas.Neher@uibk.ac.at
Gstöttner
Michaela
M
Nagl
Markus
M
Scholtz
Arne
A
Gunkel
Andreas R
AR
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors; D014433:Tympanoplasty
D000998:Antiviral Agents; D013654:Taurine; C043410:N-chlorotaurine