title: Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT.
abstract: Deciphering gene regulatory networks requires the systematic identification of functional cis-acting regulatory elements. We present a suite of web-based bioinformatics tools, called GeneACT http://promoter.colorado.edu, that can rapidly detect evolutionarily conserved transcription factor binding sites or microRNA target sites that are either unique or over-represented in differentially expressed genes from DNA microarray data. GeneACT provides graphic visualization and extraction of common regulatory sequence elements in the promoters and 3'-untranslated regions that are conserved across multiple mammalian species.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, 215 UCB, Boulder, Colorado 80309, USA.
authors.forename: Tom Hiu
authors.initials: TH
authors.lastname: Cheung
authors.forename: Yin Lam
authors.initials: YL
authors.lastname: Kwan
authors.forename: Micah
authors.initials: M
authors.lastname: Hamady
authors.forename: Xuedong
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D016678:Genome; D015894:Genome, Human; D006801:Humans; D051379:Mice; D051381:Rats; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic