title: The Meropenem Yearly Susceptibility Test Information Collection antimicrobial susceptibility program in Spain: a 5-year analysis.
abstract: The Meropenem Yearly Susceptibility Test Information Collection program is a global study providing in vitro surveillance data on antimicrobial susceptibility in centers prescribing meropenem. This study summarizes data on the activity of meropenem and 5 comparators against 4022 clinical isolates from 7 centers in Spain (1999-2003). Those bacteria intrinsically resistant to meropenem were excluded. Among Enterobacteriaceae, 100% of Enterobacter spp., Citrobacter spp., and Serratia spp. were susceptible to meropenem. Escherichia coli and Klebsiella pneumoniae susceptibilities to carbapenems were 100% and > or =98%, respectively. Extended-spectrum beta-lactamase-producing Enterobacteriaceae were 3.8% of isolates, and all of them were susceptible to meropenem. Ciprofloxacin resistance in E. coli was around 20%. Meropenem and piperacillin/tazobactam were the most active agents against Pseudomonas aeruginosa. Acinetobacter baumannii were 61-90% susceptible to carbapenems, but only 6-21% susceptible to ciprofloxacin. In this period, around 100% of oxacillin-susceptible staphylococci were susceptible to meropenem. There was no significant decrease in susceptibility to the carbapenems throughout the 5-year period. The clinical use of meropenem in 7 Spanish centers did not increase bacterial resistance to this agent in the microorganisms evaluated.
authors.affiliation: Hospital Virgen Macarena-Seville, 41080 Seville, Spain. apascual@us.es
authors.forename: Alvaro
authors.initials: A
authors.lastname: Pascual
authors.forename: E
authors.initials: E
authors.lastname: Perea
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: M
authors.initials: M
authors.lastname: Casal
authors.forename: J
authors.initials: J
authors.lastname: Garcia de Lomas
authors.forename: J A
authors.initials: JA
authors.lastname: Garcia Rodríguez
authors.forename: R
authors.initials: R
authors.lastname: Martin
authors.forename: G
authors.initials: G
authors.lastname: Soria
authors.forename: J
authors.initials: J
authors.lastname: Zapardiel
mesh_terms: D000046:Academic Medical Centers; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006801:Humans; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D013030:Spain; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000077731:Meropenem