title: ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men.
abstract: Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We measured plasma ADAMTS13 and VWF antigen levels by enzyme-linked immunosorbent assay (ELISA) in a large population-based case-control study (Study of Myocardial Infarctions Leiden [SMILE]), consisting of 560 men with a first myocardial infarction (MI) and 646 control subjects. Although ABO blood groups influenced VWF levels, they had no influence on ADAMTS13. Furthermore, there was no relationship between plasma ADAMTS13 and VWF levels. Similar to VWF, the estimated risk of MI was increased for every quartile of ADAMTS13 when compared to the lowest quartile (odds ratio, 1.5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13.
authors.affiliation: Department of Haematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.
authors.forename: Chan K N K
authors.initials: CK
authors.lastname: Chion
authors.forename: Carine J M
authors.initials: CJ
authors.lastname: Doggen
authors.forename: James T B
authors.initials: JT
authors.lastname: Crawley
authors.forename: David A
authors.initials: DA
authors.lastname: Lane
authors.forename: Frits R
authors.initials: FR
authors.lastname: Rosendaal
mesh_terms: D051722:ADAM Proteins / Q000097:blood*; D000071120:ADAMTS13 Protein; D000293:Adolescent; D000328:Adult; D000368:Aged; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000473:pathology*; D012307:Risk Factors; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D014841:von Willebrand Factor; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human