title: Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones.
abstract: The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.
authors.affiliation: Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. ullricj@wyeth.com
authors.forename: John W
authors.initials: JW
authors.lastname: Ullrich
authors.forename: Rayomand J
authors.initials: RJ
authors.lastname: Unwalla
authors.forename: Robert R
authors.initials: RR
authors.lastname: Singhaus
authors.forename: Heather A
authors.initials: HA
authors.lastname: Harris
authors.forename: Richard E
authors.initials: RE
authors.lastname: Mewshaw
mesh_terms: D018360:Crystallography, X-Ray; D047629:Estrogen Receptor beta / Q000819:agonists* / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D008024:Ligands; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D047629:Estrogen Receptor beta; D007211:Indoles; D008024:Ligands; D010797:Phthalimides