title: Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study.
abstract: Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter model is developed for the purpose of analytically investigating the elevated pressures associated with IIH and a collapsible transverse sinus. This analysis yields practical predictions regarding the degree of elevated ICPs and the effectiveness of various treatment methods. Results suggest that IIH may be caused by a sufficiently collapsible transverse sinus, but it is also possible that a stenosed sinus may persist following resolution of significant intracranial hypertension.
authors.affiliation: School of Science, Penn State Erie, The Behrend College, Erie, PA 16563-0203, USA. sas56@psu.edu
authors.forename: Scott A
authors.initials: SA
authors.lastname: Stevens
authors.forename: Michelle
authors.initials: M
authors.lastname: Previte
authors.forename: William D
authors.initials: WD
authors.lastname: Lakin
authors.forename: Nimish J
authors.initials: NJ
authors.lastname: Thakore
authors.forename: Paul L
authors.initials: PL
authors.lastname: Penar
authors.forename: Brandon
authors.initials: B
authors.lastname: Hamschin
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use; D000465:Algorithms; D002555:Cerebrospinal Fluid / Q000502:physiology; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D003251:Constriction, Pathologic / Q000150:complications / Q000503:physiopathology*; D003392:Cranial Sinuses / Q000503:physiopathology*; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D008954:Models, Biological; D011312:Pressure; D011559:Pseudotumor Cerebri / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D017287:Ventriculoperitoneal Shunt
chemical_list: D000086:Acetazolamide