Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR.
Based on fluorescence binding studies and 1D 1H NMR studies, designed synthetic analogues of NCSi-gb bind specifically with two-base bulged RNA, including HIV-2 TAR RNA, making them potential lead compounds for antiviral drug development.
Xiao
Ziwei
Z
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Zhang
Na
N
Lin
Yiqing
Y
Jones
Graham B
GB
Goldberg
Irving H
IH
D005643:Fucose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D016325:HIV Long Terminal Repeat; D015498:HIV-2 / Q000235:genetics*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D012367:RNA, Viral / Q000737:chemistry / Q000378:metabolism*; D013141:Spiro Compounds / Q000737:chemistry* / Q000378:metabolism
C520353:NCSi-gb compound; D012367:RNA, Viral; D013141:Spiro Compounds; D005643:Fucose