title: Mild and general conditions for the cross-coupling of aryl halides with pentafluorobenzene and other perfluoroaromatics.
abstract: New reaction conditions are described that enable the direct arylation of pentafluorobenzene with sterically encumbered aryl bromides and aryl chlorides. These reactions occur in high yield and under mild conditions. Notably, the reactions can be performed at 80 degrees C in isopropyl acetate with a catalyst generated by the in situ mixing of Pd(OAc)(2) and S-Phos. The enhanced scope of these transformations should further reduce the need to use pentafluorophenylboronic acid in the construction of perfluoroarenes. [reaction: see text]
authors.affiliation: Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada K1N 6N5.
authors.forename: Marc
authors.initials: M
authors.lastname: Lafrance
authors.forename: Daniel
authors.initials: D
authors.lastname: Shore
authors.forename: Keith
authors.initials: K
authors.lastname: Fagnou