Functional interactions between calmodulin and estrogen receptor-alpha.
The effects of estrogen in breast epithelial cells are mediated primarily via estrogen receptor alpha and estrogen receptor beta (ERalpha and ERbeta). Accumulating evidence implicates a role for Ca2+ and calmodulin in breast carcinoma, as well as in the function of ERalpha. Calmodulin contributes to the regulation of both ERalpha degradation and ERalpha-mediated transcriptional activation. Recent data will be summarized in this review. Models to explain the molecular mechanisms by which calmodulin modulates ERalpha function are proposed.
Li
Lu
L
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
Sacks
David B
DB
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D014158:Transcription, Genetic
D002147:Calmodulin; D047628:Estrogen Receptor alpha