title: Neural hyperplasia in chondrodermatitis nodularis chronica helicis.
abstract: BACKGROUND
  Chondrodermatitis nodularis chronica helicis (CNCH) is a common condition characterized by tender nodules of the helix, of uncertain mechanism. The pain is not explained by current physiopathological hypotheses.
  
  
  OBJECTIVE
  We sought to investigate possible nerve hyperplasia in CNCH.
  
  
  METHODS
  Thirty-seven cases of clinically typical CNCH were submitted to conventional microscopy after surgical excision and analyzed with immunohistochemistry using PS100 and neurofilament antibodies. As controls, we investigated 25 tumors of the ear with the same methods.
  
  
  RESULTS
  Large nerves (>0.1 mm in diameter) were seen in 8 of 37 cases; these were close to the cartilage or at the upper part of the ulceration. Increased numbers of small nerve sections (0.01-0.06 mm in diameter) were seen in 35 of 37 cases, with more than 20 sections per low-power field in 18 cases. Nerve hyperplasia was not observed in tumors of the ear, even in ulcerated cases.
  
  
  CONCLUSIONS
  Hypothesis based on morphologic observations.
  
  
  CONCLUSIONS
  Nerve hyperplasia is present in CNCH, but is often masked by intense vascular and inflammatory reactions. This finding may explain the induction of pain by light pressure, whereas ulcerated auricular malignant tumors are generally painless. Certain authors believe that CNCH is an equivalent of prurigo nodularis, which interestingly also shows nerve hyperplasia.
authors.affiliation: Cutaneous Histopathology Laboratory, Dermatology Clinic of the University Hospitals, Strasbourg, France. bernard.cribier@chru-strasbourg.fr
authors.forename: Bernard
authors.initials: B
authors.lastname: Cribier
authors.forename: Yannis
authors.initials: Y
authors.lastname: Scrivener
authors.forename: Bernard
authors.initials: B
authors.lastname: Peltre
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002357:Cartilage Diseases / Q000473:pathology*; D016022:Case-Control Studies; D004396:Coloring Agents; D003872:Dermatitis / Q000473:pathology*; D004425:Ear Cartilage / Q000294:innervation*; D004427:Ear Diseases / Q000473:pathology*; D004431:Ear, External / Q000294:innervation*; D004801:Eosine Yellowish-(YS); D005260:Female; D005456:Fluorescent Dyes; D006416:Hematoxylin; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry / Q000379:methods; D007249:Inflammation / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009417:Nerve Tissue / Q000473:pathology*; D013194:Staining and Labeling
chemical_list: D004396:Coloring Agents; D005456:Fluorescent Dyes; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin