title: Cisplatin plus gemcitabine with or without vinorelbine as induction chemotherapy prior to radical locoregional treatment for patients with stage III non-small-cell lung cancer (NSCLC): results of a prospective randomized study.
abstract: To evaluate possible improvement in objective response of adding vinorelbine (V) to the combination of cisplatin/gemcitabine (CG) in induction chemotherapy for stage III NSCLC, patients (n=154) aged < or =75 years, Karnofsky index > or =70%, were stratified by stage (IIIA versus IIIB) and randomly assigned to receive: C (50mg/m(2) i.v.) plus G (1250mg/m(2) i.v.) or CG plus V (25mg/m(2) i.v.). All drugs were administered on days 1 and 8 of an every 3-week cycle. At conclusion, local treatment (LT) with surgery and/or radiotherapy was scheduled. The results indicated that, following a median of 3 cycles, the overall efficacy was 65% in the CG and 61% in the CGV group. Most patients in both groups received radiotherapy as part of their LT. Pathological complete response was confirmed by surgery in 18% in the CG and 25% in the CGV group. Median progression-free survival was 368 days in the CG and 322 days in the CGV group. There were no statistically significant differences in toxicities between groups. We conclude that the CG and CGV combinations had similar efficacy and moderate toxicity, without accruing to the triplet combination.
authors.affiliation: Servicio de Oncología Médica, Hospital Central de Asturias, Julián Clavería s/n, 33006 Oviedo, Asturias, Spain. eestebang@seom.org
authors.forename: Emilio
authors.initials: E
authors.lastname: Esteban
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: de Sande
authors.forename: Noemi
authors.initials: N
authors.lastname: Villanueva
authors.forename: Norberto
authors.initials: N
authors.lastname: Corral
authors.forename: Isabel
authors.initials: I
authors.lastname: Muñiz
authors.forename: José M A
authors.initials: JM
authors.lastname: Vieitez
authors.forename: Joaquin
authors.initials: J
authors.lastname: Fra
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Fernández
authors.forename: Enrique
authors.initials: E
authors.lastname: Estrada
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Fernandez
authors.forename: Maria
authors.initials: M
authors.lastname: Luque
authors.forename: Paula
authors.initials: P
authors.lastname: Jimenez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Mareque
authors.forename: Marta
authors.initials: M
authors.lastname: Capellan
authors.forename: José M A
authors.initials: JM
authors.lastname: Buesa
authors.forename: Angel Jimenez
authors.initials: AJ
authors.lastname: Lacave
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D018450:Disease Progression; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D014747:Vinblastine; D002945:Cisplatin; D000077235:Vinorelbine; D000093542:Gemcitabine