title: SRP19 is a dispensable component of the signal recognition particle in Archaea.
abstract: In vitro, archaeal SRP54 binds SRP RNA in the absence of SRP19, suggesting the latter to be expendable in Archaea. Accordingly, the Haloferax volcanii SRP19 gene was deleted. Although normally transcribed at a level comparable to that of the essential SRP54 gene, SRP19 deletion had no effect on cell growth, membrane protein insertion, protein secretion, or ribosome levels. The absence of SRP19 did, however, increase membrane bacterioruberin levels.
authors.affiliation: Department of Life Sciences, Ben Gurion University, P.O. Box 653, Beersheva 84105, Israel.
authors.forename: Sophie
authors.initials: S
authors.lastname: Yurist
authors.forename: Idit
authors.initials: I
authors.lastname: Dahan
authors.forename: Jerry
authors.initials: J
authors.lastname: Eichler
mesh_terms: D001105:Archaea / Q000378:metabolism*; D019843:Archaeal Proteins / Q000378:metabolism*; D019642:RNA, Archaeal / Q000378:metabolism; D018271:Signal Recognition Particle / Q000378:metabolism* / Q000502:physiology
chemical_list: D019843:Archaeal Proteins; D019642:RNA, Archaeal; C117074:SRP19 protein, human; D018271:Signal Recognition Particle