title: [Massive hemorrhage in a 28-year-old male patient with intestinal Behçet's disease].
abstract: A 28-year-old man was admitted to the emergency room of our hospital after syncope and acute gastrointestinal bleeding. On the basis of numerous oral and genital ulcerations as well as uveitis anterior and erythema nodosum, the diagnosis of Behçet's disease had been confirmed previously. The bleeding focus could not be detected by endoscopy. During the next days recurrent massive hemorrhages occurred in spite of immunosuppressive therapy with steroids. Angiography revealed a circumscribed bleeding source in the colon transversum near the left colonic flexure, which was treated by superselective coil embolization. A massive hemorrhage reoccurred and required a surgical approach with a Hartmann procedure. Histology depicted bleeding into the submucosa and mucosa and an ulcer in this area as well as lymphatic infiltration of the mucosa. Immunosuppressive therapy was intensified with azathioprine and resulted in a dramatic improvement of the oral and genital ulcers. In addition, no further gastrointestinal hemorrhage occurred. Due to its higher prevalence in patients from eastern Asia, Behçet's disease poses an important differential diagnosis of intestinal hemorrhage in patients of this descent.
authors.affiliation: I. Medizinische Klinik, Johannes-Gutenberg-Universität, Mainz.
authors.forename: M
authors.initials: M
authors.lastname: Waldner
authors.forename: C
authors.initials: C
authors.lastname: Schimanski
authors.forename: W
authors.initials: W
authors.lastname: Klaas
authors.forename: F
authors.initials: F
authors.lastname: Bittinger
authors.forename: M
authors.initials: M
authors.lastname: Pitton
authors.forename: M
authors.initials: M
authors.lastname: Korenkov
authors.forename: R
authors.initials: R
authors.lastname: Kiesslich
authors.forename: M
authors.initials: M
authors.lastname: Neurath
authors.forename: P
authors.initials: P
authors.lastname: Galle
authors.forename: S
authors.initials: S
authors.lastname: Kanzler
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male