title: Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia.
abstract: BACKGROUND
  Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizophrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and function of the hippocampus. Because positive symptoms in SZ have also been associated with hippocampal structure and function, we hypothesized that variation in a DISC1 haplotype containing Ser704Cys would be significantly associated with positive symptomatology in SZ.
  
  
  METHODS
  We tested for an association between variation in a haplotype block within the DISC1 gene containing Ser704Cys and lifetime history of positive symptoms in 199 Caucasian patients with SZ.
  
  
  RESULTS
  We detected significant associations between a DISC1 haplotype containing Ser704Cys and Ser704Cys genotype and lifetime severity of delusions in SZ.
  
  
  CONCLUSIONS
  These data suggest that that the effect of DISC1 genetic variation might be associated with positive symptoms in patients with SZ.
authors.affiliation: Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA. pderosse@lij.edu
authors.forename: Pamela
authors.initials: P
authors.lastname: DeRosse
authors.forename: Colin A
authors.initials: CA
authors.lastname: Hodgkinson
authors.forename: Todd
authors.initials: T
authors.lastname: Lencz
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Burdick
authors.forename: John M
authors.initials: JM
authors.lastname: Kane
authors.forename: David
authors.initials: D
authors.lastname: Goldman
authors.forename: Anil K
authors.initials: AK
authors.lastname: Malhotra
mesh_terms: D003545:Cysteine / Q000235:genetics; D003702:Delusions / Q000175:diagnosis / Q000235:genetics*; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006212:Hallucinations / Q000175:diagnosis / Q000235:genetics*; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012694:Serine / Q000235:genetics
chemical_list: C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins; D012694:Serine; D003545:Cysteine