Convenient one pot synthesis of some novel derivatives of thiazolo[2,3-b]dihydropyrimidinone possessing 4-methylthiophenyl moiety and evaluation of their antibacterial and antifungal activities.
A series of new 2-(arylidene/5-arylfurfurylidene)-5-(4-methylthiophenyl)-6-carbethoxy-7-methyl-5H-thiazolo[2,3-b]pyrimidin-3(1H)-ones 2 and 3 have been synthesized by a three component (MCR) reaction involving 4-(4-methylthiophenyl)-5-carbethoxy-6-methyl-3,4-dihydropyrimidin-2(1H)-thione 1, monochloroacetic acid and arylaldehydes/arylfurfuraldehydes, respectively. The newly synthesized compounds were well characterized by elemental analysis, IR, (1)H NMR and mass spectral studies. The newly synthesized compounds were screened for their antibacterial and antifungal activities and have exhibited moderate to excellent growth inhibition of bacteria and fungi. The results of such studies have been discussed in this paper.
Ashok
Mithun
M
Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri 574 199, Karnataka, India. mithun41@rediffmail.com
Holla
Bantwal Shivarama
BS
Kumari
Nalilu Suchetha
NS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011744:Pyrimidinones; D013844:Thiazoles; C519545:thiazolo(2,3-b)dihydropyrimidinone