Anti-triosephosphate isomerase antibodies in cerebrospinal fluid are associated with neuropsychiatric lupus.
We detected anti-triosephosphate isomerase antibodies (anti-TPI) in cerebrospinal fluid (CSF) in 5 of 12 neuropsychiatric lupus patients (41.6%) by Western blotting. C3d index was significantly higher in anti-TPI-positive patient (n=5, median 0.446) than in anti-TPI-negative patient (n=7, median 0.098) (p=0.019) CSF samples. TPI was detected from immune complexes (IC) isolated from CSF in 2 of 2 anti-TPI-positive patients tested and was not detected from IC in 5 of 5 anti-TPI-negative patients tested. Our results suggest that anti-TPI form IC in CSF and contribute to the pathogenesis of neuropsychiatric lupus by activating the complement system.
Sasajima
Tomomi
T
Fukushima Medical University, Department of Internal Medicine II, School of Medicine, Fukushima 960-1295, Japan.
Watanabe
Hiroshi
H
Sato
Shuzo
S
Sato
Yukio
Y
Ohira
Hiromasa
H
D001323:Autoantibodies / Q000134:cerebrospinal fluid* / Q000302:isolation & purification; D015153:Blotting, Western; D003167:Complement Activation / Q000276:immunology*; D015933:Complement C3d / Q000134:cerebrospinal fluid / Q000378:metabolism; D006801:Humans; D020945:Lupus Vasculitis, Central Nervous System / Q000134:cerebrospinal fluid / Q000276:immunology*; D008863:Microspheres; D014305:Triose-Phosphate Isomerase / Q000276:immunology*
D001323:Autoantibodies; D015933:Complement C3d; D014305:Triose-Phosphate Isomerase