title: Diffuse bone marrow uptake on F-18 FDG PET in patients with myelodysplastic syndromes.
abstract: It is well known that hematopoietic cytokine stimulation can cause diffuse increase of FDG accumulation in bone marrow on PET imaging, which simulates that seen in patients with bone marrow metastases. However, diffuse bone marrow FDG uptake can be caused by other etiologies. We report 2 patients who did not have a history of hematopoietic cytokine stimulation. The FDG PET images showed diffuse bone marrow FDG uptake, and the patients were diagnosed as having myelodysplastic syndromes. These cases demonstrate that diffuse FDG uptake by bone marrow can suggest neoplastic disease of the hematopoietic tissues.
authors.affiliation: Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. kenta@idac.tohoku.ac.jp
authors.forename: Kentaro
authors.initials: K
authors.lastname: Inoue
authors.forename: Ken
authors.initials: K
authors.lastname: Okada
authors.forename: Hideo
authors.initials: H
authors.lastname: Harigae
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Taki
authors.forename: Ryoi
authors.initials: R
authors.lastname: Goto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Kinomura
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kato
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaneta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukuda
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000378:metabolism*; D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D003937:Diagnosis, Differential; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18