title: Histopathological regression of systemic AA amyloidosis after surgical treatment of a localized Castleman's disease.
abstract: Previously, we reported a case of localized plasma cell type Castleman's disease with severe hepatomegaly and reactive systemic AA amyloidosis. The amyloid deposits were demonstrated in both the hepatic tissue and in the gastric mucosa. Surgical resection of an isolated extra-hepatic tumor was performed. The laboratory findings, including SAA and IL-6, remained within normal limits and the patient's hepatomegaly subsequently showed regression. Nine years after the operation, no amyloid deposition was seen in the gastric mucosa and the patient's liver was of normal size. Our findings with long-term follow up in this case indicated that the cessation of SAA production was the probable cause of histopathological regression of AA amyloid deposits in this patient.
authors.affiliation: Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimojima
authors.forename: Yo-Ichi
authors.initials: Y
authors.lastname: Takei
authors.forename: Ko-Ichi
authors.initials: K
authors.lastname: Tazawa
authors.forename: Takahisa
authors.initials: T
authors.lastname: Gono
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Fushimi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hoshii
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000473:pathology* / Q000503:physiopathology; D005871:Castleman Disease / Q000601:surgery*; D006801:Humans; D008297:Male; D012074:Remission Induction