Current aspects of Shigella pathogenesis.
Bacillary dysentery (shigellosis) is a severe human disease caused by Shigellae. In recent years, a large amount of information has been generated regarding the host, pathogen and environmental factors that impact the pathogenesis of shigellosis at the cellular and molecular level. This review summarizes what is currently known about Shigella, detailing those factors that contribute to pathogenesis and examining the current progress in the development of a vaccine.
Torres
Alfredo G
AG
Department of Microbiology and Immunology, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 77555-1070, USA. altorres@utmb.edu
D002262:Carboxy-Lyases / Q000235:genetics / Q000502:physiology; D004405:Dysentery, Bacillary / Q000382:microbiology* / Q000503:physiopathology / Q000517:prevention & control; D004777:Environment; D004847:Epithelial Cells / Q000382:microbiology; D005798:Genes, Bacterial; D044404:Genomic Islands / Q000235:genetics; D006801:Humans; D007501:Iron / Q000378:metabolism; D010957:Plasmids / Q000235:genetics; D022621:Shiga Toxin / Q000378:metabolism; D012760:Shigella / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D022281:Shigella Vaccines; D014617:Vacuoles / Q000382:microbiology; D014774:Virulence
D022281:Shigella Vaccines; D022621:Shiga Toxin; D007501:Iron; D002262:Carboxy-Lyases; C021520:lysine decarboxylase