New route to azaspirocycles via the organolithium-mediated conversion of beta-alkoxy aziridines into cyclopentenyl amines.
A new three-step route to azaspirocycles involving the organolithium-mediated conversion of beta-alkoxy aziridines into substituted cyclopentenyl amines, hydroboration, and cyclization has been developed. The methodology is utilized in the construction of the pentacyclic ring system of cephalotaxine. [reaction: see text]
Moore
Stephen P
SP
Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.
Coote
Susannah C
SC
O'Brien
Peter
P
Gilday
John
J