[Advances in study of murine double minute 2/p53 passway with breast cancer].
Mutant or aberrant regulation of expressing products of p53 gene results in losing its tumor suppressive function, which is often seen in many malignancies, including breast cancer. Oncoprotein MDM2 plays a primary role in regulating P53, and these two form an automregulatory feedback loop. mdm2/p53 passway performs important function in development, progression,therapy and prognosis of breast cancer. Besides, more and more studies show that some other molecular markers in breast cancer, such as PI3K/Akt/mTOR, p14ARF, and Her2/neu can regulate this passway unneglectedly. The purpose of this review is to summarize not only the relations between mdm2/p53 passway and pathological characters, therapy and prognosis of breast cancer, but also the relations of this passway with some other molecular proteins in breast cancer.
Ba
Yan-hua
YH
Department of Oncology Chemotherapy, Peking University Third Hospital, Beijing 100083, China.
Li
Hui-ping
HP
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008954:Models, Biological; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53; C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2