Are T cells at the origin of B cell lymphomas?
Lymphoma pathogenesis is at least in some cases related to transformed B cells (BCs) arising from germinal centre reactions (GCRs). In this article possible deregulations of GCRs are investigated using in silico simulations. It is found that the final differentiation of BCs as regulated by helper T cells (TCs) is the best candidate mechanism for such a deregulation. This shifts the paradigm of BC lymphoma pathogenesis from BC transformations to an emphasized role of TC-BC interactions.
Meyer-Hermann
Michael E
ME
Frankfurt Institute for Advanced Studies (FIAS), Max von Laue Str. 1, 60438 Frankfurt/Main, Germany. M.Meyer-Hermann@fias.uni-frankfurt.de
D017209:Apoptosis / Q000502:physiology; D001402:B-Lymphocytes / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D016207:Cytokines / Q000502:physiology; D020566:Dendritic Cells, Follicular / Q000502:physiology; D005246:Feedback / Q000502:physiology; D018858:Germinal Center / Q000502:physiology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000503:physiopathology*; D008433:Mathematics; D008954:Models, Biological; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*; D013997:Time Factors
D016207:Cytokines