Flavonoid-induced acute nephropathy by Cupressus funebris Endl (Mourning Cypress).
Worldwide use of herbal therapy has increased dramatically in recent years. Most herbal therapies were not regulated as medicines, and their adverse effects often were underreported. We report a patient who developed acute renal failure, acute hepatic failure, autoimmune hemolytic anemia, and thrombocytopenia after oral intake of hot-water extract of Cupressus funebris Endl (Mourning Cypress), which is rich in flavonoids. Her renal biopsy showed acute tubular necrosis, interstitial nephritis, and hemoglobin casts. The clinical course and pathological findings were consistent with flavonoid-induced acute nephropathy. We emphasize that flavonoids are not harmless and may induce acute life-threatening renal damage.
Lee
Jia-Jung
JJ
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan.
Chen
Hung-Chun
HC
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced; D029781:Cupressus / Q000633:toxicity*; D005260:Female; D005419:Flavonoids / Q000633:toxicity*; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D017114:Liver Failure, Acute / Q000139:chemically induced; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced; D008517:Phytotherapy / Q000009:adverse effects*; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D013921:Thrombocytopenia / Q000139:chemically induced
D005419:Flavonoids; D010936:Plant Extracts