Effects of terephthalic acid on rat lipid metabolism.
OBJECTIVE
To study the effect of terephthalic acid (TPA) on lipid metabolism in Sprague-Dawley (SD) rats.


METHODS
Five groups of SD rats that ingested 0%, 0.04%, 0.2%, 1%, and 5% TPA, respectively, were included in a 90-day subchronic feeding study. Effects of TPA on levels of serum protein, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), total antioxidative capability (T-AOC), superoxide dismutase (SOD) and malondialdehyde (MDA) were observed. Urine samples were collected and analyzed for concentration of ion.


RESULTS
TPA decreased the level of serum T-AOC in a dose dependent manner. The contents of serum and bladder MDA significantly decreased in 1% and 5% TPA ingestion groups. Serum CuZn superoxide dismutase (CuZnSOD) lowered in groups of 0.2%, 1%, and 5% TPA. TPA subchronic feeding had no significant influences on serum TC, LDL or HDL, but increased serum TG, TP and ALB after administration of 0.04% and/or 0.2% TPA. Concentrations of urinary Ca2+, Mg2+, Na+, and K+ were elevated in 1% and 5% TPA groups.


CONCLUSIONS
Antioxidative potential decreased after TPA exposure. MDA increase in serum and bladder tissues was one of the most important reactions in rats which could protect themselves against TPA impairment. The decrease of serum CuZnSOD was related to the excretion of Zn2+.
Dai
Gui-Dong
GD
Jiangsu Key Laboratory of Applied Toxicology, Nanjing Medical University, Nanjing 210029, Jiangsu, China. daiguidong@163.com
Cui
Lun-Biao
LB
Song
Ling
L
Liu
Ru
R
He
Jun
J
Wang
Yu-Bang
YB
Cheng
Jian-Feng
JF
Chang
Hebron C
HC
Wang
Xin-Ru
XR
D000818:Animals; D000975:Antioxidants / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005260:Female; D007477:Ions / Q000652:urine; D050356:Lipid Metabolism / Q000187:drug effects*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013481:Superoxides / Q000097:blood; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain
D000975:Antioxidants; D001798:Blood Proteins; D007477:Ions; D008074:Lipoproteins; D010795:Phthalic Acids; D014280:Triglycerides; D013481:Superoxides; D008315:Malondialdehyde; C011363:terephthalic acid; D002784:Cholesterol