title: Successful resection of Hypothalamic Hamartoma with intractable gelastic seizures--by transcallosal subchoroidal approach.
abstract: A 19-year old female with intractable gelastic seizures was found to have 0.7 x 1.8 x 1.8 cm elliptical mass on the floor of the third ventricle. The signal intensity on the Magnetic Resonance Imaging (MRI) was consistent with the Hypothalamic Hamartoma (HH). Ictal EEG demonstrated rhythmic 7 Hz waves over Fp2, F4, and C4 with spreading to the right temporal region and then bilaterally. Ictal Single Photon Emission Computerized Tomography (SPECT) showed hyperperfusion at hypothalamic and medial frontopolar regions. The patient underwent surgical resection using Trans Callosal Subchoroidal Approach (TCSA) to the third ventricle. Pathological finding confirmed the diagnosis of hypothalamic hamartoma. Following the operation, she has been seizure free up to 12 months. Thereafter, provoked seizures seldom occurred and there has been improvement in her memory, emotional control and independence. This appears to be the first report of this surgical approach for HH, which is less likely to disturb memory function compared to previously described interfoniceal approach.
authors.affiliation: Chulalongkorn Comprehensive Epilepsy Program, Bangkok, Thailand.
authors.forename: Krishnapundha
authors.initials: K
authors.lastname: Bunyaratavej
authors.forename: Chaichon
authors.initials: C
authors.lastname: Locharernkul
authors.forename: Supatporn
authors.initials: S
authors.lastname: Tepmongkol
authors.forename: Sukalaya
authors.initials: S
authors.lastname: Lerdlum
authors.forename: Shanop
authors.initials: S
authors.lastname: Shuangshoti
authors.forename: Surachai
authors.initials: S
authors.lastname: Khaoroptham
mesh_terms: D002648:Child; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006222:Hamartoma / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000175:diagnosis / Q000601:surgery*; D007031:Hypothalamus / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome