Role of sex hormones in cardiovascular resistance to atropine in rats at rest and during stress.
Castration of males and females reduces the sensitivity of cardiac chronotropic function to atropine and potentiates the vascular component in the reaction to atropine in females (during stress) and males (at rest and during stress). Our results show that estrogens and androgens increase the sensitivity of the cardiovascular system to cholinergic influences at rest and during stress.
Semenova
M A
MA
Department of Human and Animal Physiology, N. G. Chemyshevskii Saratov State University. semenovama@mail.ru
Klimova
O A
OA
Anishchenko
T G
TG
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006339:Heart Rate; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000503:physiopathology*
D012739:Gonadal Steroid Hormones; D001285:Atropine