title: Can luteal regression be reversed?
abstract: The corpus luteum is an endocrine gland whose limited lifespan is hormonally programmed. This debate article summarizes findings of our research group that challenge the principle that the end of function of the corpus luteum or luteal regression, once triggered, cannot be reversed. Overturning luteal regression by pharmacological manipulations may be of critical significance in designing strategies to improve fertility efficacy.
authors.affiliation: Division of Basic Biomedical Sciences, Sanford School of Medicine of The University of South Dakota, Vermillion, SD 57069, USA. carlos.telleria@usd.edu
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Telleria
mesh_terms: D000735:Androstenedione / Q000494:pharmacology; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007986:Luteinizing Hormone / Q000494:pharmacology; D003341:Luteolysis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism; D011981:Receptors, Prolactin / Q000235:genetics / Q000378:metabolism
chemical_list: D011944:Receptors, Androgen; D011981:Receptors, Prolactin; D000735:Androstenedione; D011374:Progesterone; D007986:Luteinizing Hormone