title: Assessment of regional GABA(A) receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy.
abstract: Periventricular leukomalacia (PVL) due to hypoxic-ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABA(A) receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABA(A) receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABA(A) receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABA(A) receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.
authors.affiliation: Division of Nuclear Medicine, Department of Diagnostic Radiology, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, Republic of Korea. jdlee@yumc.yonsei.ac.kr
authors.forename: Jong Doo
authors.initials: JD
authors.lastname: Lee
authors.forename: Hae-Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Park
authors.forename: Dong Goo
authors.initials: DG
authors.lastname: Kim
authors.forename: Dong-Wook
authors.initials: DW
authors.lastname: Rha
authors.forename: Eung Yeop
authors.initials: EY
authors.lastname: Kim
authors.forename: Dong Ik
authors.initials: DI
authors.lastname: Kim
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Mijin
authors.initials: M
authors.lastname: Yun
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Ryu
authors.forename: Jinu
authors.initials: J
authors.lastname: Lee
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Jeong
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Lee
authors.forename: Chang Il
authors.initials: CI
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D001665:Binding Sites; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000503:physiopathology; D002547:Cerebral Palsy / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002648:Child; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D049268:Positron-Emission Tomography; D011963:Receptors, GABA-A / Q000502:physiology*
chemical_list: C483765:2'-fluoroflumazenil; D005462:Fluorine Radioisotopes; D011963:Receptors, GABA-A; D005442:Flumazenil