title: Failure to maintain an aspirin-desensitized state in a patient with aspirin-exacerbated respiratory disease.
abstract: BACKGROUND
  Aspirin desensitization is a useful therapy in patients with aspirin-exacerbated respiratory disease.
  
  
  OBJECTIVE
  To describe the clinical course of a man with aspirin-exacerbated respiratory disease who was unable to be desensitized to oral aspirin.
  
  
  METHODS
  A standard aspirin desensitization protocol was used to achieve a maximum dose of 650 mg of oral aspirin. The patient initially tolerated this dose of aspirin.
  
  
  RESULTS
  Within days of desensitization, the patient began to react to 650 mg of aspirin. Monitored challenge with this dose of aspirin led to marked decrease in forced expiratory volume in 1 second and pronounced nasal and ocular symptoms.
  
  
  CONCLUSIONS
  We present a patient with classic aspirin-exacerbated respiratory disease, who despite undergoing a standard aspirin desensitization protocol was unable to maintain his desensitized state.
authors.affiliation: Naval Medical Center San Diego, Allergy and Immunology Clinic, San Diego, California 92106, USA. AAWhite@NMCSD.MED.NAVY.MIL
authors.forename: Andrew A
authors.initials: AA
authors.lastname: White
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Hope
authors.forename: Donald D
authors.initials: DD
authors.lastname: Stevenson
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity; D006801:Humans; D008297:Male; D012140:Respiratory Tract Diseases / Q000276:immunology*; D017211:Treatment Failure
chemical_list: D001241:Aspirin