Effects of various media on the activity of NXL103 (formerly XRP 2868), a new oral streptogramin, against Haemophilus influenzae.
The activity of NXL103 against 108 strains of Haemophilus influenzae was tested using Haemophilus test media (HTM) obtained from various sources. With the exception of those obtained with stored HTM, MICs did not differ significantly, with MIC(50) and MIC(90) values of 0.5 and 0.5 to 1 microg/ml, respectively, in each medium.
Pankuch
Glenn A
GA
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Hoellman
Dianne
D
Bryskier
André
A
Lowther
John
J
Appelbaum
Peter C
PC
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006193:Haemophilus influenzae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D025364:Streptogramin A / Q000493:pharmacokinetics / Q000494:pharmacology*; D025381:Streptogramin B / Q000493:pharmacokinetics / Q000494:pharmacology*; D025361:Streptogramins / Q000493:pharmacokinetics / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D004338:Drug Combinations; D025361:Streptogramins; C509060:flopristin, linopristin drug combination; D025381:Streptogramin B; D025364:Streptogramin A