title: Challenges in forensic toxicology of skeletonized human remains.
abstract: Forensic toxicologists typically work with body fluids such as blood or urine, as well as visceral tissues such as liver. Very little work has been done to properly understand the utility of drug concentrations in bone tissue in a toxicologic examination. Literature reports suggest that detection of selected drugs in bone tissues is possible, but challenging work remains to determine the implications of bone tissue drug concentration measurements with respect to time lines of drug ingestion and deposition into bone, tissue sampling and sensitivity requirements, and environmental effects on measurements and their interpretation.
authors.affiliation: Department of Forensic Science, Laurentian University, 935 Ramsey Lake Rd., Sudbury, Ontario, Canada P3E 2C6.
authors.forename: James
authors.initials: J
authors.lastname: Watterson
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000737:chemistry* / Q000378:metabolism; D053593:Forensic Toxicology / Q000379:methods* / Q000639:trends; D006801:Humans; D023421:Models, Animal; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000378:metabolism; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations