title: Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease.
abstract: The diagnosis of fibrosis within liver disease is important for prognosis, stratification for treatment, and monitoring of treatment efficacy. The rising incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) has driven the search for accurate non-invasive tools of liver fibrosis within this condition. With the aid of a systematic review, we explore how the field has evolved from the discovery of simple blood parameters to panel markers of liver fibrosis. We will discuss the biological plausibility, limitations, potential uses, and emerging diagnostic techniques of non-invasive markers in this rapidly expanding field.
authors.affiliation: Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton, Mail point 811, Level D, South Academic Block, Southampton General Hospital, Southampton S016 6YD, UK. guhaneil@hotmail.com
authors.forename: I N
authors.initials: IN
authors.lastname: Guha
authors.forename: J
authors.initials: J
authors.lastname: Parkes
authors.forename: P R
authors.initials: PR
authors.lastname: Roderick
authors.forename: S
authors.initials: S
authors.lastname: Harris
authors.forename: W M
authors.initials: WM
authors.lastname: Rosenberg
mesh_terms: D015415:Biomarkers / Q000097:blood; D005234:Fatty Liver / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers