title: Fluoroquinolones and risk for methicillin-resistant Staphylococcus aureus, Canada.
abstract: Receipt of fluoroquinolones was the predominant risk factor for Clostridium difficile-associated disease (CDAD) during an epidemic in Quebec, Canada. To determine the role of antimicrobial drugs in facilitating healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) colonization and infection and to compare this role with their effects on methicillin-susceptible S. aureus infection and CDAD, we conducted a retrospective cohort study of patients in a Quebec hospital. For 7371 episodes of care, data were collected on risk factors, including receipt of antimicrobial drugs. Crude and adjusted hazard ratios (AHR) were calculated by Cox regression. Of 150 episodes of MRSA colonization and 23 of MRSA infection, fluoroquinolones were the only antimicrobials that increased risk for colonization (AHR 2.57, 95% confidence interval [CI] 1.84-3.60) and infection (AHR 2.49, 95% CI 1.02-6.07). Effect of antimicrobial drugs on MRSA colonization and infection was similar to effect on CDAD and should be considered when selecting antimicrobial drugs to treat common infections.
authors.affiliation: University of Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Louiselle
authors.initials: L
authors.lastname: LeBlanc
authors.forename: Jacques
authors.initials: J
authors.lastname: Pépin
authors.forename: Krystel
authors.initials: K
authors.lastname: Toulouse
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Ouellette
authors.forename: Marie-Andrée
authors.initials: MA
authors.lastname: Coulombe
authors.forename: Marie-Pier
authors.initials: MP
authors.lastname: Corriveau
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Alary
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016360:Clostridioides difficile / Q000187:drug effects; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011792:Quebec; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D008712:Methicillin