title: Common Kibra alleles are associated with human memory performance.
abstract: Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.
authors.affiliation: Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland. papas@bli.unizh.ch
authors.forename: Andreas
authors.initials: A
authors.lastname: Papassotiropoulos
authors.forename: Dietrich A
authors.initials: DA
authors.lastname: Stephan
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Huentelman
authors.forename: Frederic J
authors.initials: FJ
authors.lastname: Hoerndli
authors.forename: David W
authors.initials: DW
authors.lastname: Craig
authors.forename: John V
authors.initials: JV
authors.lastname: Pearson
authors.forename: Kim-Dung
authors.initials: KD
authors.lastname: Huynh
authors.forename: Fabienne
authors.initials: F
authors.lastname: Brunner
authors.forename: Jason
authors.initials: J
authors.lastname: Corneveaux
authors.forename: David
authors.initials: D
authors.lastname: Osborne
authors.forename: M Axel
authors.initials: MA
authors.lastname: Wollmer
authors.forename: Amanda
authors.initials: A
authors.lastname: Aerni
authors.forename: Daniel
authors.initials: D
authors.lastname: Coluccia
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hänggi
authors.forename: Christian R A
authors.initials: CR
authors.lastname: Mondadori
authors.forename: Andreas
authors.initials: A
authors.lastname: Buchmann
authors.forename: Eric M
authors.initials: EM
authors.lastname: Reiman
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Caselli
authors.forename: Katharina
authors.initials: K
authors.lastname: Henke
authors.forename: Dominique J-F
authors.initials: DJ
authors.lastname: de Quervain
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000818:Animals; D001288:Attention; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D002135:Calcium-Binding Proteins / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006239:Haplotypes; D006624:Hippocampus / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008279:Magnetic Resonance Imaging; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008568:Memory; D051379:Mice; D008875:Middle Aged; D010750:Phosphoproteins; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013557:Switzerland; D014481:United States
chemical_list: C472551:CLSTN2 protein, human; D002135:Calcium-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins; D011506:Proteins; C513637:WWC1 protein, human