title: Hinokiresinol inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction.
abstract: The antiallergic effect of hinokiresinol isolated from the whole plant of TRAPA Pseudoincisa S. at. Z. was measured in vitro and in vivo. Hinokiresinol not only potently inhibited beta-hexosaminidase release from RBL-2H3 cells induced by IgE, with an IC50 value of 98 microM, but also inhibited the proinflammatory cytokines IL-6, IL-4 and TNF-alpha in RBL-2H3 cells stimulated by IgE. Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE.
authors.affiliation: College of Pharmacy, Kyung Hee University, Seoul, Korea.
authors.forename: Eun-Ah
authors.initials: EA
authors.lastname: Bae
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Park
authors.forename: Hye-Joung
authors.initials: HJ
authors.lastname: Yang
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007073:Immunoglobulin E; D020128:Inhibitory Concentration 50; D007274:Injections, Intraperitoneal; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors*; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019684:Magnoliopsida; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy
chemical_list: D018926:Anti-Allergic Agents; D017705:Lignans; D010636:Phenols; C119821:hinokiresinol; D007975:Leukotriene B4; D007073:Immunoglobulin E