Tetrahydroquinoline sulfonamides as gamma-secretase inhibitors.
The development of a novel series of tetrahydroquinoline-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
Asberom
Theodros
T
Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. theodros.asberom@spcop.com
Bara
Thomas A
TA
Clader
John W
JW
Greenlee
William J
WJ
Guzik
Henry S
HS
Josien
Hubert B
HB
Li
Wei
W
Parker
Eric M
EM
Pissarnitski
Dmitri A
DA
Song
Lixin
L
Zhang
Lili
L
Zhao
Zhiqiang
Z
D000544:Alzheimer Disease / Q000188:drug therapy*; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D006801:Humans; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
D011480:Protease Inhibitors; D011804:Quinolines; D013449:Sulfonamides; D053829:Amyloid Precursor Protein Secretases