title: Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products.
abstract: Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products are reported. Key steps involve copper-mediated, enantioselective oxidative dearomatization to prepare the azaphilone core and olefin cross-metathesis for side-chain installation. [reaction: see text]
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, MA 02215, USA
authors.forename: Jianglong
authors.initials: J
authors.lastname: Zhu
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D001565:Benzoates / Q000138:chemical synthesis* / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis*; D015394:Molecular Structure; D010860:Pigments, Biological / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001565:Benzoates; D001578:Benzopyrans; D001688:Biological Products; D010860:Pigments, Biological; C494154:azaphilone; C521221:mitorubrin