title: [Interferon-alpha and ribavirin treatment in a patient with hepatitis C virus-associated cutaneous periarteritis nodosa].
abstract: BACKGROUND
  Hepatitis C virus (HCV) frequently causes leucocytoclastic vasculitis as a result of type II or III cryoglobulinemia. HCV-associated vasculitis without cryoglobulinemia is less common.
  
  
  METHODS
  A 33-year-old woman consulted for infiltrative necrotic purpura of the lower limbs, responsible for leg ulcers measuring less than 1 cm. Histopathological examination revealed vasculitis affecting the hypodermic arterioles and caused by periarteritis nodosa. No extracutaneous involvement was observed. The patient had presented asymptomatic untreated HVC infection (genotype 3) for two years. Antiviral treatment resulted in elimination of the patient's viremia and no relapse of skin lesions was observed two years after the end of treatment.
  
  
  CONCLUSIONS
  This patient presented vasculitis due to cutaneous nodular periarteritis associated with HVC without cryoglobulinemia. Hepatic impairment was mild and did not require any antiviral treatment. No further skin involvement was seen after treatment with colchicine and because the patient's viral genotype was favorable, we decided to initiate antiviral therapy. This therapeutic approach should be considered by dermatologists, but it is nevertheless important to assess the risk of interferon-induced aggravation of vasculitis.
authors.affiliation: Service de Dermatologie, Centre Hospitalier Universitaire, Université François-Rabelais, Tours, France.
authors.forename: M
authors.initials: M
authors.lastname: Naouri
authors.forename: Y
authors.initials: Y
authors.lastname: Bacq
authors.forename: M C
authors.initials: MC
authors.lastname: Machet
authors.forename: C
authors.initials: C
authors.lastname: Rogez
authors.forename: L
authors.initials: L
authors.lastname: Machet
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007871:Leg Ulcer / Q000821:virology; D010488:Polyarteritis Nodosa / Q000188:drug therapy / Q000821:virology*; D011693:Purpura / Q000821:virology; D012254:Ribavirin / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin