[Effect of Kunyining capsule on reproductive endocrine-immune functions in ovariectomized rats].
OBJECTIVE
To study the therapeutic mechanism of Kunyining (KYN) on the climacteric syndrome and provide the pharmacodynamic basis.


METHODS
Ovariectomized rats were used as model to observe the effect of KYN on weight and the index of the organ of OVX rats. The concentration of E2, FSH, LH, PRL, BGP and IL-2 in serum were measured by competitive radio-immunological methods.


RESULTS
KYN could obviously increase the index of uterus and adrenal gland in OVX rats, and enhance the contents of E2, IL-2 and BGP. The level of FSH, LH, PRL in serum were decreased.


CONCLUSIONS
KYN can regulate beneficially the unbalanced reproductive endocrine-immune network, which is the pharmacological basis of KYN treating climacteric syndrome.
Yang
Ming-hua
MH
Zhejiang Provinical Institute of Chinese Materia Medica, Hangzhou, China. ymh702@126.com
Yang
Su-bei
SB
Long
Sen
S
Jin
Zu-han
ZH
Jin
Jie
J
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007376:Interleukin-2 / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D009929:Organ Size / Q000187:drug effects; D015675:Osteocalcin / Q000097:blood; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry; D011388:Prolactin / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000187:drug effects
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D015675:Osteocalcin; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone