Keeping transcriptional activators under control.
Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this process.
Kodadek
Thomas
T
Department of Internal Medicine , University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, USA. thomas.kodadek@utsouthwestern.edu
Sikder
Devanjan
D
Nalley
Kip
K
D000818:Animals; D006801:Humans; D008957:Models, Genetic; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D013997:Time Factors; D015534:Trans-Activators / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology; D015533:Transcriptional Activation; D025801:Ubiquitin / Q000378:metabolism*
D015534:Trans-Activators; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex