title: Modified radical neck dissection and minimal invasive tumor surgery in the middle of split course of concomitant chemoradiotherapy of advanced HNSCC.
abstract: OBJECTIVE
  The effectiveness of modified radical neck dissection with concomitant chemoradiotherapy in patients with N2/3 advanced head and neck cancer was evaluated.
  
  
  METHODS
  Retrospective study of 35 patients treated at the University Hospital, Medical University, Innsbruck. The treatment consisted of a split course radiation up to 70 Gy with concomitant chemotherapy with Mytomicin C and 5-fluorouracil. Neck dissection and/or tumor resection was performed between the two cycles of radiation and chemotherapy.
  
  
  RESULTS
  The 2-year progression-free survival was 64%, locoregional control 92% and overall survival 55. Observed toxicities included mucositis (grade 3, 35%; grade 4, 16%), neutropenia (grade 4, 28%), and thrombocytopenia (grade 4, 26%). No complications related to modified radical neck dissection were observed.
  
  
  CONCLUSIONS
  Intermittent neck dissection was highly effective in controlling the neck disease. Mitomycin C-based chemoradiotherapy for treatment of locally advanced cancer seems to be an option to cisplatin-based regimens.
authors.affiliation: Department of Otorhinolaryngology, University Hospital, Medical University Innsbruck, Austria. Ilona.schwentner@uibk.ac.at
authors.forename: Ilona
authors.initials: I
authors.lastname: Schwentner
authors.forename: Joachim
authors.initials: J
authors.lastname: Schmutzhard
authors.forename: Jan
authors.initials: J
authors.lastname: Andrle
authors.forename: Alfred
authors.initials: A
authors.lastname: Haidenberger
authors.forename: Walter F
authors.initials: WF
authors.lastname: Thumfart
authors.forename: Alexander
authors.initials: A
authors.lastname: De Vries
authors.forename: Georg M
authors.initials: GM
authors.lastname: Sprinzl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D016685:Mitomycin / Q000009:adverse effects / Q000627:therapeutic use*; D037981:Neck Dissection / Q000379:methods; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012189:Retrospective Studies
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin; D005472:Fluorouracil