title: Neuro-bioenergetic concepts in cancer prevention and treatment.
abstract: Cancer remains one of the most difficult and elusive disorders to prevent and treat, despite great efforts in research and treatment over the last 30 years. Researchers have tried to understand the pathogenesis of cancer by discovering the single cellular mechanism or pathway derived from a genetic mutation. There are limited efforts made toward discovering a unified concept of cancer. We propose a neuro-bioenergetic concept of cancer pathogenesis based on the central mechanism of cellular hyperexcitability via inducible overexpression of voltage-gated ion channels, ligand-gated channels and neurotransmitters. Exploration of this concept could lead to a better understanding of the cause of cancer as well as developing more effective and specific strategies toward cancer prevention and treatment.
authors.affiliation: Allergy Research Group, Immunology Research, 4010 Moorpark Avenue, Ste 119, San Jose, CA 5117, United States. niscba@aol.com <niscba@aol.com>
authors.forename: Ba X
authors.initials: BX
authors.lastname: Hoang
authors.forename: D
authors.initials: D
authors.lastname: Graeme Shaw
authors.forename: Phuong
authors.initials: P
authors.lastname: Pham
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Levine
mesh_terms: D000109:Acetylcholine / Q000737:chemistry / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry; D002273:Carcinogens / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D018698:Glutamic Acid / Q000737:chemistry; D006801:Humans; D008274:Magnesium / Q000737:chemistry; D009154:Mutation; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy*; D018377:Neurotransmitter Agents / Q000737:chemistry; D009569:Nitric Oxide / Q000737:chemistry; D058915:Purinergic P1 Receptor Antagonists; D015222:Sodium Channels / Q000737:chemistry; D013002:Somatomedins / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D002273:Carcinogens; D005227:Fatty Acids; D018377:Neurotransmitter Agents; D058915:Purinergic P1 Receptor Antagonists; D015222:Sodium Channels; D013002:Somatomedins; D009569:Nitric Oxide; D018698:Glutamic Acid; D016202:N-Methylaspartate; D008274:Magnesium; D000109:Acetylcholine