title: Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).
abstract: Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial recognition test and Morris water maze. Peptides HLDF-6 and PEDF-6 possessed neuroprotective activity and counteracted the toxic effect of Abeta(25-35). Peptides HLDF-6 and PEDF-6 mainly improved long-term memory and working memory, respectively.
authors.affiliation: Laboratory of Neurochemistry, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Storozheva
authors.forename: A T
authors.initials: AT
authors.lastname: Proshin
authors.forename: S S
authors.initials: SS
authors.lastname: Zhokhov
authors.forename: V V
authors.initials: VV
authors.lastname: Sherstnev
authors.forename: I L
authors.initials: IL
authors.lastname: Rodionov
authors.forename: V M
authors.initials: VM
authors.lastname: Lipkin
authors.forename: I A
authors.initials: IA
authors.lastname: Kostanyan
mesh_terms: D016229:Amyloid beta-Peptides / Q000008:administration & dosage*; D000818:Animals; D005136:Eye Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000494:pharmacology*; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D015843:Serpins / Q000008:administration & dosage / Q000494:pharmacology*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D016229:Amyloid beta-Peptides; D005136:Eye Proteins; D009414:Nerve Growth Factors; D009842:Oligopeptides; D010446:Peptide Fragments; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor; C074636:amyloid beta-protein (25-35); C513648:threonyl-glycyl-glutamyl-asparaginyl-histidylarginine