title: Pain related potentials by electrical stimulation of skin for detection of small-fiber neuropathy in HIV.
abstract: We compared the sensitivity of pain related evoked potentials (PREP), a novel electrophysiological technique, with standard nerve conduction (SNC) testing in the diagnosis of small fiber neuropathy in 47 patients with HIV infection and 31 age matched controls. SNC testing revealed a neuropathy in only 31%, whereas PREP was abnormal in 74% of symptomatic patients. This result hints that PREP is more sensitive in the detection of HIV-associated small fiber neuropathy than standard neurography.
authors.affiliation: Department of Neurology, University of Essen, Hufelandstr. 55, 45122, Essen, Germany, and Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK. zaza.katsarava@uni-essen.de
authors.forename: Zaza
authors.initials: Z
authors.lastname: Katsarava
authors.forename: Ozgüt
authors.initials: O
authors.lastname: Yaldizli
authors.forename: Christina
authors.initials: C
authors.lastname: Voulkoudis
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Diener
authors.forename: Helger
authors.initials: H
authors.lastname: Kaube
authors.forename: Matthias
authors.initials: M
authors.lastname: Maschke
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004558:Electric Stimulation / Q000009:adverse effects / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology* / Q000528:radiation effects; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology / Q000528:radiation effects; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology*; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects; D012867:Skin / Q000294:innervation* / Q000528:radiation effects