title: Tetrahydroquinoline sulfonamides as gamma-secretase inhibitors.
abstract: The development of a novel series of tetrahydroquinoline-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
authors.affiliation: Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. theodros.asberom@spcop.com
authors.forename: Theodros
authors.initials: T
authors.lastname: Asberom
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Bara
authors.forename: John W
authors.initials: JW
authors.lastname: Clader
authors.forename: William J
authors.initials: WJ
authors.lastname: Greenlee
authors.forename: Henry S
authors.initials: HS
authors.lastname: Guzik
authors.forename: Hubert B
authors.initials: HB
authors.lastname: Josien
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Eric M
authors.initials: EM
authors.lastname: Parker
authors.forename: Dmitri A
authors.initials: DA
authors.lastname: Pissarnitski
authors.forename: Lixin
authors.initials: L
authors.lastname: Song
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D006801:Humans; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011480:Protease Inhibitors; D011804:Quinolines; D013449:Sulfonamides; D053829:Amyloid Precursor Protein Secretases