title: [Effects of modified longdan xiegan decoction on hyperandrogenism in patients with polycystic ovary syndrome of stagnant fire in Gan channel type].
abstract: OBJECTIVE
  To observe the therapeutic effect of modified Longdan Xiegan Decoction (LXD) on hyperandrogenism in patients with polycystic ovary syndrome (POS) of stagnant fire in Gan channel type.
  
  
  METHODS
  Forty-eight patients were divided into two groups: the LXD group (25 cases) treated with LXI) for 3 months, and the Diane-35 group (23 cases) with Diane-35. Condition of menstruation, acne, hairiness were observed, basal body temperature (BBT) was measured, and the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), free testosterone (FT), and androstenedione (A) were detected before and after 3 months' treatment. Meanwhile, adverse reaction was observed.
  
  
  RESULTS
  After treatment, the condition of menstrual disorder, acne and single-phase BBT were improved significantly, and serum levels of LH, LH/FSH, FT and A decreased in both groups (P < 0.05), showed insignificant difference between them (P > 0.05). The PRL level dropped in the LXD group (P < 0.05), which significantly lower than that in the Diane-35 group (P < 0.05). There were 3 cases with adverse reaction of irregular colporrhagia and 5 cases with nausea and vomiting in the Diane-35 group, while no adverse reaction in the LXD group occurred.
  
  
  CONCLUSIONS
  Modified LXD could significantly improve the condition in hyperandrogenism patients with POS of stagnant fire in Gan channel type.
authors.affiliation: The First Affiliated Hospital of Guangzhou University of TCM. taolili@3126.com
authors.forename: Li-li
authors.initials: LL
authors.lastname: Tao
authors.forename: Yu-zhen
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Xia
authors.initials: X
authors.lastname: Sang
mesh_terms: D000293:Adolescent; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000188:drug therapy* / Q000209:etiology; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000188:drug therapy
chemical_list: D004365:Drugs, Chinese Herbal; C526720:longdan xiegan decoction