[Establishment of rabbit orbital hypertelorism model and evaluation of effects of surgical correction].
OBJECTIVE
To establish a rabbit model of orbital hypertelorism for plastic and reconstructive surgery and evaluate the surgical effects.


METHODS
Orbital osteotomies and medial translocation was performed in 16 New Zealand rabbits (4 to 6 months old) by combined intracranial-extracranial approach. The interorbital distance (IOD) and bone healing between the orbits were evaluated with gross measurement. X-ray and histological examinations were performed immediately and 12 weeks after the operation.


RESULTS
The average IOD of the rabbits was 0.74 cm after completion of the operation, but increased to 0.96 cm 12 weeks after the operation, showing significant relapse of orbital hypertelorism (P<0.01).


CONCLUSIONS
The IOD can be decreased successfully in this rabbit model.
Yuan
Qiang
Q
Department of Plastic and Reconstructive Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. yuanqiang_73@163.com
Liu
Da-lie
DL
Yuan
Ji-long
JL
Shan
Lei
L
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006972:Hypertelorism / Q000209:etiology / Q000601:surgery*; D008297:Male; D011817:Rabbits; D019651:Plastic Surgery Procedures / Q000379:methods; D013518:Surgery, Plastic / Q000379:methods