Sebaceous hyperplasia and skin cancer in patients undergoing renal transplant.
BACKGROUND
One previous study has shown a higher prevalence of sebaceous hyperplasia (SH) in patients with heart transplant on immunosuppressive drugs as compared with sex-matched control patients.


OBJECTIVE
We set out to compare the prevalence of SH in a cohort of patients undergoing renal transplant with age- and sex-matched control patients and to find any association with nonmelanoma skin cancer (NMSC) in these patients.


METHODS
In all, 117 patients with renal transplant and 117 age- and sex-matched control patients were screened for the prevalence of SH and NMSC.


RESULTS
We found that 29.9% of our patients with renal transplant had SH; 16 of 35 (45.7%) of these patients had a history of NMSC as compared with 6 of 82 (7.3%) patients without SH (P < .001, odds ratio 10.7). In the age- and sex-matched control group, a total of 28 patients (23.9%) had one or more lesions of SH.


CONCLUSIONS
This study is small and will require confirmation with larger cohort studies.


CONCLUSIONS
In our cohort of patients with renal transplant we found a strong association of NMSC with SH. This association remained significant after correction of factors such as age, sex, skin type, and duration of transplant.
Salim
Asad
A
Department of Dermatology, School of Medicine, University Hospital of North Staffordshire, Staffordshire, United Kingdom.
Reece
Sarah M
SM
Smith
Andrew G
AG
Harrison
Denise
D
Ramsay
Helen M
HM
Harden
Paul N
PN
Fryer
Anthony A
AA
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006965:Hyperplasia; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012627:Sebaceous Glands / Q000473:pathology*; D012871:Skin Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology*; D006113:United Kingdom / Q000453:epidemiology