title: Three cases of lymphomatoid papulosis with a CD56+ immunophenotype.
abstract: We report 3 cases of lymphomatoid papulosis (LyP) with a CD56+, cytotoxic immunophenotype. All 3 patients presented with clinical histories typical of LyP, with one patient having associated mycosis fungoides. Histologically, two cases were type A LyP and one was type B. All 3 cases demonstrated a T-cell receptor clone in lesional skin without evidence of blood involvement. The atypical lymphocytes in each of the 3 cases expressed cytotoxic granules (T-cell intracellular antigen-1+ and granzyme B+) and were CD8+ and CD56+. Expression of CD56 is associated with a poor prognosis in subcutaneous panniculitis-like T-cell lymphoma and blastic natural killer cell lymphoma. However, the two cases of CD56+ LyP previously reported and the 3 cases in this series all appear to be pursuing an indolent course with no evidence of systemic disease.
authors.affiliation: Skin Tumor Unit, St John's Institute of Dermatology, St Thomas' Hospital, USA. sandyflann@hotmail.com
authors.forename: Sandy
authors.initials: S
authors.lastname: Flann
authors.forename: Guy E
authors.initials: GE
authors.lastname: Orchard
authors.forename: E Mary
authors.initials: EM
authors.lastname: Wain
authors.forename: Robin
authors.initials: R
authors.lastname: Russell-Jones
mesh_terms: D000328:Adult; D001706:Biopsy; D019002:CD56 Antigen / Q000032:analysis*; D003602:Cytotoxicity, Immunologic; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping / Q000379:methods; D017731:Lymphomatoid Papulosis / Q000150:complications / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications
chemical_list: D019002:CD56 Antigen