title: Herpes simplex and Epstein-Barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine.
abstract: Multiple herpes virus co-infection is a very rare complication in patients with chronic lymphocytic leukemia (CLL). We describe a patient with a CLL who developed an herpes virus lymphadenitis. Inmunohistochemical study was positive for HSV-1, HSV-2, and Epstein-Barr Virus (EBV). The coinfection of EBV with a profile of expresion of viral latent genes type III, is usually seen in inmunodepressed patients. To the best of our knowledge, this is the first reported case of a multiple human herpes virus infection mimicking Richter syndrome.
authors.affiliation: Department of Hematology, Hospital Clínic, IDIBAPS, University of Barcelona, Spain. smerca@clinic.ub.es
authors.forename: Santiago
authors.initials: S
authors.lastname: Mercadal
authors.forename: Antonio
authors.initials: A
authors.lastname: Martinez
authors.forename: Benet
authors.initials: B
authors.lastname: Nomdedeu
authors.forename: María
authors.initials: M
authors.lastname: Rozman
authors.forename: Anna
authors.initials: A
authors.lastname: Gaya
authors.forename: Olga
authors.initials: O
authors.lastname: Salamero
authors.forename: Elías
authors.initials: E
authors.lastname: Campo
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000998:Antiviral Agents / Q000008:administration & dosage; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D015967:Gene Expression Regulation, Viral / Q000187:drug effects; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics; D018258:Herpesvirus 2, Human / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy* / Q000235:genetics / Q000821:virology; D008199:Lymphadenitis / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000821:virology*; D014740:Vidarabine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D014740:Vidarabine; C024352:fludarabine; D000212:Acyclovir