Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats.
The present study was aimed to evaluate the anti-hyperglycemic efficacy of Murraya koenigii in STZ-induced diabetic rats. Oral administration of ethanolic extract of M. koenigii at a dose of 200 mg/kg/ b.w./day for a period of 30 days significantly decreased the levels of blood glucose, glycosylated hemoglobin, urea, uric acid and creatinine in diabetic treated group of animals. Determination of plasma insulin level revealed the insulin stimulatory effect of the extract. The results suggest that M. koenigii possesses statistically significant hypoglycemic potential in STZ-induced diabetic rats. The M. koenigii extract appeared to be more effective than glibenclamide, a known antidiabetic drug.
Arulselvan
P
P
Department of Biochemistry and Molecular Biology, University of Madras, Chennai, Tamil Nadu, India.
Senthilkumar
G P
GP
Sathish Kumar
D
D
Subramanian
S
S
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D006442:Glycated Hemoglobin / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D032101:Murraya / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014527:Uric Acid / Q000652:urine
D001786:Blood Glucose; D001798:Blood Proteins; D003404:Creatinine; D005905:Glyburide; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D007004:Hypoglycemic Agents; D014527:Uric Acid