Human leucocyte antigen-C in B chronic lymphocytic leukaemia.
This study aimed at characterising the distribution of human leucocyte antigen (HLA)-C alleles in a large group of patients with B chronic lymphocytic leukaemia from Southeastern Spain. Ninety-eight adult patients and 194 geographically and ethnically matched controls were studied. HLA-C was determined by polymerase chain reaction sequence-specific primers (PCR-SSP) and PCR-sequence-specific oligonucleotides (SSO) methods. The HLA-Cw*16 allele frequency was found to be significantly increased amongst patients compared with controls in our population (27.6% vs. 12.4%, P = 0.0012, Pc = 0.016). HLA-C dimorphism was also analysed but no association was found.
Montes-Ares
Olga
O
Department of Immunology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Moya-Quiles
M Rosa
MR
Montes-Casado
María
M
Guerra-Pérez
Natalia
N
Campillo
J Antonio
JA
González
Consuelo
C
López-Bermejo
Antonio
A
Tamayo
Manuel
M
Majado
M Juliana
MJ
Parrado
Antonio
A
Muro
Manuel
M
Marín
Luis
L
Alvarez-López
M Rocío
MR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods
D015236:HLA-C Antigens