title: Dense gas processing of polymeric controlled release formulations.
abstract: Dense gas techniques, which utilize the properties of fluids in the vicinity of their critical points, are of increasing interest in the processing of pharmaceuticals. It is generally known that dense gases can be used for extractions, chromatographic separations and chemical synthesis due to their liquid-like solvation power and gas-like mass-transfer properties. The processes can be conducted at moderate operating conditions and are thus suitable for many heat-labile compounds such as proteins, biocompatible polymers and pharmaceuticals. Recent applications of dense gas techniques include micronization, crystallization of high-purity particles, sterilization and preparation of microencapsulated drug formulations. The following paper provides a brief overview of dense gases and various processing techniques to fabricate polymeric drug-loaded formulations for controlled release purposes.
authors.affiliation: School of Chemical Engineering and Industrial Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Andrian
authors.initials: A
authors.lastname: Tandya
authors.forename: Raffaella
authors.initials: R
authors.lastname: Mammucari
authors.forename: Fariba
authors.initials: F
authors.lastname: Dehghani
authors.forename: Neil R
authors.initials: NR
authors.lastname: Foster
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005740:Gases / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012997:Solvents
chemical_list: D003692:Delayed-Action Preparations; D005740:Gases; D011108:Polymers; D012997:Solvents