title: Systemic fungemia and hepatic localizations of Fusarium solani in a liver transplanted patient: an emerging fungal agent.
abstract: The incidence of invasive fungal infection is increasing especially in the field of transplantation, affecting as many as 50% of bone marrow transplant (BMT) patients with neutropenia and 5-20% of solid-organ transplant (SOT) recipients. Fusarium species are soil saprophytes and plant pathogens. They may cause superficial mycoses or important opportunistic infections in patients with bone marrow suppression and neutropenia, they have been rarely described in solid organ recipients, and up to now there have been no reports of such infection in isolated liver transplanted patients. We describe a case of disseminated Fusarium solani infection with hepatic localization in a liver transplanted patient that resolved with the administration of amphotericin B. Our observation confirms that Fusarium spp. are emerging pathogens that may most frequently affect not only BMT patients and patients with hematological malignancies, but also SOT patients. They may cause both localized and disseminated infection. In conclusion, Fusarium spp. etiology should be considered in the context of infectious diseases following liver transplantation.
authors.affiliation: Department of Internal Medicine and Gastroenterology, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Lodato
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Tamé
authors.forename: Marco
authors.initials: M
authors.lastname: Montagnani
authors.forename: Vittorio
authors.initials: V
authors.lastname: Sambri
authors.forename: Giovanna
authors.initials: G
authors.lastname: Liguori
authors.forename: Francesco
authors.initials: F
authors.lastname: Azzaroli
authors.forename: Paolo
authors.initials: P
authors.lastname: Costigliola
authors.forename: Gianluca
authors.initials: G
authors.lastname: Grazi
authors.forename: Enrico
authors.initials: E
authors.lastname: Roda
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mazzella
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology*; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D008099:Liver / Q000382:microbiology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B