title: Skin capacitance mapping of psoriasis.
abstract: BACKGROUND
  The pathobiological dynamics of psoriatic lesions are complex and difficult to perceive by clinical inspection alone. Non-invasive bioengineering methods may prove to be useful in this field.
  
  
  OBJECTIVE
  To identify some subtle capacitance variations in the stratum corneum of chronic psoriasis lesions.
  
  
  METHODS
  The newly developed method of skin capacitance imaging was used to provide non-optical images of the hydration of the superficial layers of the stratum corneum.
  
  
  RESULTS
  Compared to the uninvolved skin, psoriatic lesions usually showed an overall lowered capacitance, admixed with foci of moderately higher capacitance. Still other sharply circumscribed blotches with higher capacitance were present. The latter aspect corresponded to inflammatory areas. Sweating appeared markedly impaired inside the lesions. The fingerprint of some patients was altered, thus potentially interfering with the current biometric security procedures using the same method.
  
  
  CONCLUSIONS
  Skin capacitance imaging is a non-invasive, non-optical method that distinguishes three contrasting levels of stratum corneum hydration in psoriatic lesions. The lowest capacitance level probably corresponded to xerotic orthokeratosis. The medium capacitance level presumably identified foci of parakeratosis and clumps of neutrophils. The highest capacitance level suggested exsudation at the site of prominent vessel dilation and dermal inflammation. Impaired sweating in the psoriatic lesions may potentially interfere with body thermoregulation.
authors.affiliation: Department of Dermatopathology, University Hospital Sart Tilman, Liège, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Xhauflaire-Uhoda
authors.forename: C
authors.initials: C
authors.lastname: Piérard-Franchimont
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D003878:Dermatoglyphics; D003880:Dermatology / Q000295:instrumentation; D025802:Electric Capacitance; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology*; D013545:Sweat Glands / Q000378:metabolism / Q000473:pathology; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water