title: New route to azaspirocycles via the organolithium-mediated conversion of beta-alkoxy aziridines into cyclopentenyl amines.
abstract: A new three-step route to azaspirocycles involving the organolithium-mediated conversion of beta-alkoxy aziridines into substituted cyclopentenyl amines, hydroboration, and cyclization has been developed. The methodology is utilized in the construction of the pentacyclic ring system of cephalotaxine. [reaction: see text]
authors.affiliation: Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Moore
authors.forename: Susannah C
authors.initials: SC
authors.lastname: Coote
authors.forename: Peter
authors.initials: P
authors.lastname: O'Brien
authors.forename: John
authors.initials: J
authors.lastname: Gilday