[Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking].
OBJECTIVE
To observe the effects of H. dulcis on relieving alcohol toxicity by animal experiments.


METHODS
Male kunming mice were ovraiectomized and randomly divided into 5 groups: control group, model group, and aqueous extracts of H. dulcis group at 0.5, 0.25, 0.125 g x mL(-1). The acute alcohlism animals induced by gastral administration with "Er Guo Tou" and the alchol concentrations in serum were detected after treated with the extracts within 0.5-3 h by biochemical enzymes.


RESULTS
The alcohol concentration in blood was up to the maximum in 0.5-1.5 h. However, the alcohol concentrations in blood of aqueous extract from H. dulcis group were decreased in 0.5-3 h. The activity of ADH in the liver in aqueous extract of H. dulcis group was increased in 2-3 h, while it was significantly increased in 1-1.5 h (P <0.05).


CONCLUSIONS
The aqueous extract of H. dulcis could reduce the alchol concentration in blood of animals and inrease the activity of ADH after given alcohol. It means the extract has the effect of relieving alcohol toxicity and preventing drunkenness through restraining the absorption of alcohol in the gastrointestinal tract and promoting the metabolism of alcohol in the liver.
Chen
Shao-hong
SH
Beijing University of Chinese Medicine, China.
Zhong
Gan-sheng
GS
Li
Ai-li
AL
Li
Shao-hua
SH
Wu
Li-kun
LK
D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood* / Q000633:toxicity; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D027823:Rhamnaceae / Q000737:chemistry; D012639:Seeds / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D000431:Ethanol; D000426:Alcohol Dehydrogenase