Comparison of Prussian blue and apple-pectin efficacy on 137Cs decorporation in rats.
Cesium-137 (137Cs) is one of the most important nuclear fission elements that contaminated the environment after the explosion of the Chernobyl nuclear power plant in Ukraine (1986). The aim of the study was to compare the efficacy of two chelating agent, Prussian blue and apple-pectin on 137cesium decorporation in rats. Rats were intravenously injected with a solution of 137cesium (5 kBq per rat). Chelating agents, Prussian blue or apple-pectin were given immediately after Cs contamination and during 11 days by addition of each chelating agent in drinking water at a concentration corresponding to 400 mg kg(-1) day(-1). Efficiency was evaluated 11 days after contamination (at the end of treatment) through their ability to promote Cs excretion and to reduce the radionuclide accumulation in some retention compartments (blood, liver, kidneys, spleen, skeleton and in the remaining carcass). In these conditions after treatment with Prussian blue a fivefold increase in fecal excretion of Cs was observed and was associated with a reduction in the radionuclide retention in the main organs measured. In contrast, no significant differences were observed between untreated rats and rats treated with apple-pectin. These observations were discussed in terms of ability of pectins to bind Cs and compared to recently published results obtained after treatment of Cs-contaminated children with this chelate.
Le Gall
B
B
CEA/DSV/DRR/SRCA/LRT, Bruyères-le-Châtel, France. Beatrice.le-gall@cea.fr
Taran
F
F
Renault
D
D
Wilk
J-C
JC
Ansoborlo
E
E
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002588:Cesium Radioisotopes / Q000493:pharmacokinetics*; D005295:Ferrocyanides / Q000494:pharmacology*; D008297:Male; D027845:Malus; D010368:Pectins / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002588:Cesium Radioisotopes; D005295:Ferrocyanides; D010368:Pectins; C000170:ferric ferrocyanide