Stem cell neural differentiation: A model for chemical biology.
Stem cells can produce progenies that constitute an organism or a tissue while replenishing (renewing) themselves. The ability to produce large quantities of stage-specific cells from self-renewing stem cells in a precisely controlled manner makes it possible to dissect out complex interactions among macromolecules along development, such as early brain development at the global level. These cellular differentiation pathways also serve as templates for identifying biological effects of novel or existing chemical compounds. Thus, stem cells find their most powerful use in chemical biology, which may ultimately lead to applications in regenerative medicine.
Krencik
Robert
R
Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Center, Wisconsin Stem Cell Research Program, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA.
Zhang
Su-Chun
SC
D002454:Cell Differentiation; D009474:Neurons / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology*