Voxelwise correlational analyses of white matter integrity in multiple cognitive domains in schizophrenia.
Patients with schizophrenia show deficits in several neurocognitive domains. However, the relationship between white matter integrity and performance in these domains is poorly understood. The authors conducted neurocognitive testing and diffusion tensor imaging in 25 patients with schizophrenia. Performance was examined for tests of verbal declarative memory, attention, and executive function. Relationships between fractional anisotropy and cognitive performance were examined by using voxelwise correlational analyses. In each case, better performance on these tasks was associated with higher levels of fractional anisotropy in task-relevant regions.
Lim
Kelvin O
KO
Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA. kolim@umn.edu
Ardekani
Babak A
BA
Nierenberg
Jay
J
Butler
Pamela D
PD
Javitt
Daniel C
DC
Hoptman
Matthew J
MJ
D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000175:diagnosis* / Q000378:metabolism; D003337:Corpus Callosum / Q000378:metabolism / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism / Q000473:pathology; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D012559:Schizophrenia / Q000175:diagnosis* / Q000378:metabolism