Integration of auditory and visual communication information in the primate ventrolateral prefrontal cortex.
The integration of auditory and visual stimuli is crucial for recognizing objects, communicating effectively, and navigating through our complex world. Although the frontal lobes are involved in memory, communication, and language, there has been no evidence that the integration of communication information occurs at the single-cell level in the frontal lobes. Here, we show that neurons in the macaque ventrolateral prefrontal cortex (VLPFC) integrate audiovisual communication stimuli. The multisensory interactions included both enhancement and suppression of a predominantly auditory or a predominantly visual response, although multisensory suppression was the more common mode of response. The multisensory neurons were distributed across the VLPFC and within previously identified unimodal auditory and visual regions (O'Scalaidhe et al., 1997; Romanski and Goldman-Rakic, 2002). Thus, our study demonstrates, for the first time, that single prefrontal neurons integrate communication information from the auditory and visual domains, suggesting that these neurons are an important node in the cortical network responsible for communication.
Sugihara
Tadashi
T
Department of Neurobiology, University of Rochester Medical Center, Rochester, New York 14642, USA.
Diltz
Mark D
MD
Averbeck
Bruno B
BB
Romanski
Lizabeth M
LM
D000161:Acoustic Stimulation / Q000379:methods; D000819:Animal Communication; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D005260:Female; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*