title: Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127.
abstract: OBJECTIVE
  A phase II trial of the oral epidermal growth factor receptor (EGFR) inhibitor erlotinib in patients with gastroesophageal adenocarcinomas stratified according to primary tumor location into two groups: gastroesophageal junction (GEJ)/cardia and distal gastric adenocarcinomas.
  
  
  METHODS
  Patients with a histologically proven diagnosis of adenocarcinoma of the GEJ or stomach (ST) that was unresectable or metastatic; presence of measurable disease; no prior chemotherapy for advanced or metastatic cancer; Zubrod performance status (PS) of 0 to 1; and adequate renal, hepatic, and hematologic function were treated with erlotinib 150 mg/d orally. Patient characteristics were median age, GEJ-63 years, ST-64 years; sex, GEJ-84% male and 16% female, ST-60 male and 40 female; Zubrod PS, GEJ-25 had a PS of 0 and 18 had a PS 1, ST-13 had a PS of 0 and 12 had a PS of 1.
  
  
  RESULTS
  Percentage of common toxicities were skin rash, 86% and 72%; fatigue, 51% and 44%; and AST/ALT elevation, 28% and 28%, respectively for GEJ and ST. There has been one confirmed complete response, three confirmed partial responses (PRs) and one unconfirmed PR for an overall response probability of 9% confirmed (95% CI, 3% to 22%), all occurring in GEJ stratum. No responses were observed in ST stratum. The median survival was 6.7 months in GEJ and 3.5 months in ST stratum. Neither intratumoral EGFR, transforming growth factor-alpha or phosphorylated Akt kinase expression nor plasma proteomic analyses were predictive of clinical outcome. No somatic mutations of the EGFR exons 18, 19, or 21 were detected and there was no gross amplification of EGFR by fluorescence in situ hybridization.
  
  
  CONCLUSIONS
  Erlotinib is active in patients with GEJ adenocarcinomas, but appears inactive in gastric cancers. The molecular correlates examined were not predictive of the patient therapeutic response.
authors.affiliation: University of Arizona Cancer Center, Tucson, AZ 85724, USA. tdragovich@azcc.arizona.edu
authors.forename: Tomislav
authors.initials: T
authors.lastname: Dragovich
authors.forename: Sheryl
authors.initials: S
authors.lastname: McCoy
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Fenoglio-Preiser
authors.forename: Jiang
authors.initials: J
authors.lastname: Wang
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: Benedetti
authors.forename: Amanda F
authors.initials: AF
authors.lastname: Baker
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Hackett
authors.forename: Susan G
authors.initials: SG
authors.lastname: Urba
authors.forename: Ken S
authors.initials: KS
authors.lastname: Zaner
authors.forename: Charles D
authors.initials: CD
authors.lastname: Blanke
authors.forename: James L
authors.initials: JL
authors.lastname: Abbruzzese
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D000069347:Erlotinib Hydrochloride; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D004943:Esophagogastric Junction; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride