title: A randomized controlled trial of a smoking cessation intervention among people with a psychotic disorder.
abstract: OBJECTIVE
  Despite extremely high rates of smoking among individuals with psychotic disorders and the associated financial and health costs, few studies have investigated the efficacy of smoking cessation interventions among this group. The purpose of this study was to compare an integrated psychological and nicotine replacement therapy intervention for people with a psychotic disorder with routine care alone.
  
  
  METHODS
  The authors recruited 298 regular smokers with a psychotic disorder residing in the community and randomly assigned them to a routine care comparison condition (N=151) or an eight-session, individually administered smoking cessation intervention (N=147), which consisted of nicotine replacement therapy, motivational interviewing, and cognitive behavior therapy. Outcome variables included continuous and point-prevalence abstinence rates, smoking reduction status, and changes in symptoms and functioning.
  
  
  RESULTS
  While there were no overall differences between the treatment group and comparison group in abstinence rates, a significantly higher proportion of smokers who completed all treatment sessions stopped smoking at each of the follow-up occasions (point-prevalence rates: 3 months, 30.0% versus 6.0%; 6 months, 18.6% versus 4.0%; and 12 months, 18.6% versus 6.6%). Smokers who completed all treatment sessions were also more likely to have achieved continuous abstinence at 3 months (21.4% versus 4.0%). There was a strong dose-response relationship between treatment session attendance and smoking reduction status, with one-half of those who completed the intervention program achieving a 50% or greater reduction in daily cigarette consumption across the follow-ups, relative to less than one-fifth of the comparison subjects. There was no evidence of any associated deterioration in symptoms or functioning.
  
  
  CONCLUSIONS
  These findings demonstrate the utility of a nicotine replacement therapy plus motivational interviewing/cognitive behavior therapy smoking cessation intervention among individuals with a psychotic disorder. Further development of more efficacious interventions is required for those who do not respond to existing interventions.
authors.affiliation: Centre for Mental Health Studies, University of Newcastle, University Dr., Callaghan, NSW 2308, Australia. Amanda.Baker@newcastle.edu.au
authors.forename: Amanda
authors.initials: A
authors.lastname: Baker
authors.forename: Robyn
authors.initials: R
authors.lastname: Richmond
authors.forename: Melanie
authors.initials: M
authors.lastname: Haile
authors.forename: Terry J
authors.initials: TJ
authors.lastname: Lewin
authors.forename: Vaughan J
authors.initials: VJ
authors.lastname: Carr
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Taylor
authors.forename: Sylvia
authors.initials: S
authors.lastname: Jansons
authors.forename: Kay
authors.initials: K
authors.lastname: Wilhelm
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D015897:Comorbidity; D003376:Counseling / Q000379:methods; D005260:Female; D006801:Humans; D007407:Interviews as Topic / Q000379:methods; D008297:Male; D009042:Motivation; D009538:Nicotine / Q000008:administration & dosage / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000453:epidemiology / Q000523:psychology / Q000628:therapy*; D012907:Smoking / Q000453:epidemiology / Q000523:psychology; D016540:Smoking Cessation / Q000379:methods*; D000074606:Smoking Prevention; D016896:Treatment Outcome
chemical_list: D009538:Nicotine