Preservation solutions for solid organ transplantation.
Solid organ transplantation was one of the greatest medical advances of the 20th century. Current preservation technology falls short of maintaining organs ex vivo in perpetuity. This review examines the biochemical basis of organ degradation in response to ischaemia, preservation solution composition and potential future organ preservation technology.
Wilson
C H
CH
The Liver/ Renal Unit, The Freeman Hospital, High Heaton, Newcastle-upon-Tyne, NE7 7DN, UK. c4moon@doctors.org.uk
Brook
N R
NR
Talbot
D
D
D002118:Calcium / Q000737:chemistry; D003102:Colloids / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019188:Organ Preservation Solutions / Q000737:chemistry* / Q000592:standards; D016377:Organ Transplantation; D017382:Reactive Oxygen Species / Q000737:chemistry; D015427:Reperfusion Injury / Q000517:prevention & control
D003102:Colloids; D019188:Organ Preservation Solutions; D017382:Reactive Oxygen Species; D002118:Calcium