title: A revised model for spermatogonial expansion in man: lessons from non-human primates.
abstract: We have recently described a revised scheme for spermatogonial expansion in non-human primates. We proposed that A(pale)-spermatogonia act as self-renewing progenitors and premeiotic germ cells are organized and divide as small clones. Here, we are revisiting the model described for man and propose a modified scheme for spermatogonial expansion. Our revised model shows high similarity to the scheme proposed for non-human primates and is in accordance with all previous and present data.
authors.affiliation: Department of Cell Biology and Physiology, Center for Research in Reproductive Physiology, University of Pittsburgh School of Medicine, W952 Biomedical Sciences Tower, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Jens
authors.initials: J
authors.lastname: Ehmcke
authors.forename: Stefan
authors.initials: S
authors.lastname: Schlatt
mesh_terms: D000328:Adult; D000818:Animals; D049109:Cell Proliferation; D002999:Clone Cells; D006801:Humans; D008297:Male; D023421:Models, Animal; D011323:Primates / Q000502:physiology*; D013091:Spermatogenesis / Q000502:physiology*; D013093:Spermatogonia / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology*