[Methodological thoughts on clinical efficacy evaluation with multiple clinical trials].
Some clinical trials showed that the efficacy of traditional Chinese medicine was not good as the efficacy of western medicine even thoush clinical doctors have been using traditional medicine effectively. Such a result originated from improper application of western medical thoughts in routine clinical efficacy evaluation. To find differences from effective cases with non-effective cases and put the differences into the indication of next clinical trial would conform to the differentiation theory in traditional Chinese medicine. The differences, whether positively or negatively related to the efficacy, could be obtained from all information including symptom evaluation, tongue appearance, pulse feeling and biological parameters with non-linear and other statistical methods. More specific indication finding would be the key task for clinical efficacy evaluation via multiple clinical trials.
Lv
Ai-Ping
AP
China Academy of Chinese Medical Sciences, Beijing 100700, China. lap@jzjt.com
Wang
Yong-Yan
YY
D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal