title: [Clinical analysis in diagnosis and treatment of 11 patients with hereditary renal cell carcinoma].
abstract: OBJECTIVE
  To evaluate the diagnosis and treatment of hereditary renal cell carcinoma.
  
  
  METHODS
  Clinical data of 11 patients with hereditary renal cell carcinoma were analyzed retrospectively. Eight patients were male and 3 were female, age ranged from 32 to 67 (mean: age 48 years). Four cases were bilateral renal cell carcinoma, and 4 were multiple renal cell carcinoma. Two cases were diagnosed as Von Hippel-Lindau syndrome, 6 as familial clear cell renal cell cancer, and 3 as hereditary papillary renal carcinoma.
  
  
  RESULTS
  Ten patients performed nephron-sparing surgery and/or radical nephrectomy and 1 had no operation. The patients were followed up from 12 to 114 months. Tumor recurrence was observed in 4 patients, 1 patient died of tumor metastasis, and 2 died of other causes. Four patients survived free of tumor.
  
  
  CONCLUSIONS
  Hereditary renal carcinoma appears in the youth, and it is predominantly multiple and bilateral. Nephron-sparing surgery is the standard method of treatment for the patients.
authors.affiliation: Department of Urology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China. oldgong@sohu.com
authors.forename: Da-xin
authors.initials: DX
authors.lastname: Gong
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Ze-liang
authors.initials: ZL
authors.lastname: Li
authors.forename: Yuan-jun
authors.initials: YJ
authors.lastname: Jiang
authors.forename: Zhi-xi
authors.initials: ZX
authors.lastname: Sun
authors.forename: Chui-ze
authors.initials: CZ
authors.lastname: Kong
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies