[Probiotics--should we change the treatment strategy for pouchitis?].
Pouchitis is an idiopathic inflammatory bowel disease, which occurs in up to 50% of patients operated on for ulcerative colitis with ileal pouch-anal anastomosis (IPAA). Treatment of pouchitis is still to a large extent empirical, but recently more randomized, double-blind placebo-controlled trials have been conducted. This article reviews the possible treatments for pouchitis, focusing especially on treatment with probiotics, which seem to be a new and promising alternative to antibiotics. We are currently doing clinical trials to determine whether a probiotic is an effective treatment for chronic inflammatory bowel disease.
Klinge
Lone Gabriels
LG
Odense Universitetshospital, Medicinsk Gastroenterologisk Afdeling S, Odense C. lone.klinge@ouh.fyns-amt.dk
Kjeldsen
Jens
J
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D019449:Pouchitis / Q000188:drug therapy / Q000628:therapy*; D017410:Practice Guidelines as Topic; D019936:Probiotics / Q000627:therapeutic use*; D012008:Recurrence
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008795:Metronidazole; D002939:Ciprofloxacin