Composite EBV negative peripheral T-cell lymphoma and diffuse large B-cell lymphoma involving the ileum: a case report and a systematic review of the literature.
We report a case of an intestinal peripheral T-cell lymphoma (PTCL) with a concurrent diffuse large B-cell lymphoma (DLBL) involving the ileum and a regional lymph node. The patient presented with an abdominal mass. The terminal ileum showed a diffuse and monotonous population of small CD3-positive T cells. The T-cell receptor gamma (TCRgamma) gene was rearranged by PCR while the immunoglobulin heavy chain (IgH) gene was not. A separate section of the ileum showed a colliding large B-cell proliferation. The regional lymph node showed a diffuse proliferation of large centroblasts positive for CD20 and CD79a admixed with small T cells and showed a rearranged IgH receptor gene without evidence of a clonally rearranged TCRgamma gene. Both the PTCL and DLBL components were negative for EBV. A review and analysis of the pertinent literature describing composite T- and B-cell lymphomas is performed and reported.
Abou-Elella
Ashraf A
AA
Department of Pathology, Penn State College of Medicine, The Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA. aabouelella@psu.edu
Nifong
Thomas P
TP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017252:CD3 Complex / Q000096:biosynthesis; D020031:Epstein-Barr Virus Infections / Q000150:complications; D019675:Genes, T-Cell Receptor gamma; D004854:Herpesvirus 4, Human / Q000378:metabolism; D007082:Ileum / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral / Q000821:virology; D010641:Phenotype
D017252:CD3 Complex