title: Case-orientated approach to the management of hepatocellular adenoma.
abstract: BACKGROUND
  Treatment of suspected hepatocellular adenoma (HA) remains controversial. The aim of this study was to evaluate the management of HA at a time when magnetic resonance imaging (MRI) and computed tomography (CT) are highly sensitive methods for diagnosing HA.
  
  
  METHODS
  Between January 2000 and January 2005, data from 48 consecutive women with HA (median age 36 years) were prospectively collected. The protocol for diagnostic work-up consisted of multiphasic MRI or CT. Management was observation if the tumour was smaller than 5 cm and surgical intervention if it was 5 cm or larger.
  
  
  RESULTS
  The median follow-up was 24 (range 3-73) months. Sixteen (33 per cent) patients had invasive procedures because of tumour size 5 cm or larger, malignant characteristics or haemorrhage. The remaining 32 patients (67 per cent) were observed; haemorrhage and malignant degeneration did not occur and none of the lesions showed enlargement after withdrawal of oral contraceptives. Multiple HAs were found in 32 (67 per cent) patients; liver steatosis was significantly more common in these patients than in those with a solitary lesion (59 versus 19 per cent; P = 0.008).
  
  
  CONCLUSIONS
  Observation of adenomas smaller than 5 cm is justified because of improved radiological reliability. Resection should be reserved for patients with malignant tumour characteristics or with single lesions 5 cm or larger.
authors.affiliation: Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: D J
authors.initials: DJ
authors.lastname: van der Windt
authors.forename: N F M
authors.initials: NF
authors.lastname: Kok
authors.forename: S M
authors.initials: SM
authors.lastname: Hussain
authors.forename: P E
authors.initials: PE
authors.lastname: Zondervan
authors.forename: I P J
authors.initials: IP
authors.lastname: Alwayn
authors.forename: R A
authors.initials: RA
authors.lastname: de Man
authors.forename: J N M
authors.initials: JN
authors.lastname: IJzermans
mesh_terms: D018248:Adenoma, Liver Cell / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D003276:Contraceptives, Oral