[The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus].
OBJECTIVE
To investigate the role of MMP-2, MT1-MMP and TIMP-2 in the carcinogenesis of oral lichen planus (OLP).


METHODS
Immunohistochemistry was performed to examine the expression of OLP and compare with that of NOM.


RESULTS
The expression of these proteinases significantly increased from NOM, non-atrophic OLP, to atrophic OLP and OSCC. The expression of MMP-2 and MT1-MMP in atrophic OLP was significantly higher than in non-atrophic OLP. Furthermore, the expression of TIMP-2 consequently increased with the increasing of the MMP, but the increase of TIMP-2 was less than that of MMP.


CONCLUSIONS
MMP may be useful marker to judge the possibility of malignant change of OLP.
Zhang
Wei-ping
WP
Department of Oral Pathology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Chen
Yu
Y
Geng
Ning
N
Tian
Kun
K
Bao
Dong-mei
DM
Yang
Ming-zhong
MZ
D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017676:Lichen Planus, Oral / Q000378:metabolism* / Q000473:pathology; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism*
D019716:Tissue Inhibitor of Metalloproteinase-2; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D053511:Matrix Metalloproteinase 14