title: Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein.
abstract: The concept of utilizing the methods of directed evolution for tuning the enantioselectivity of synthetic achiral metal-ligand centers anchored to proteins has been implemented experimentally for the first time.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim/Ruhr, Germany. reetz@mpi-muelheim.mpg.de
authors.forename: Manfred T
authors.initials: MT
authors.lastname: Reetz
authors.forename: Jérôme J-P
authors.initials: JJ
authors.lastname: Peyralans
authors.forename: Andrea
authors.initials: A
authors.lastname: Maichele
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Matthias
authors.initials: M
authors.lastname: Maywald
mesh_terms: D000179:Acrylates / Q000737:chemistry; D002384:Catalysis; D019020:Directed Molecular Evolution; D004798:Enzymes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D015723:Gene Library; D006860:Hydrogen Bonding; D008958:Models, Molecular; D016296:Mutagenesis; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D004798:Enzymes; D012238:Rhodium; C036658:acrylic acid