[Baclofen-associated encephalopathy in a hemodialysis patient with hiccups].
Baclofen is a centrally acting gamma-ammino butyric acid agonist that is used like muscular relaxant in disorders with spasticity and intractable hiccups. Although encouraging and safe results were provided 5 mg/day in hemodialysis patients, his pharmacokinetic and pharmacodinamic properties are not well known in end stage renal disease. We present here the case of a hemodialysis patient with intractable hiccups who developed baclofen-associated encephalopathy with this recommended dose.
Quintana
L F
LF
Servicio de Nefrología y Trasplante Renal, Hospital Clinic, Barcelona. lfquintana@clinic.ub.es
Lladó
A
A
Butjosa
M
M
Santamaría
J
J
Torras
A
A
Poch
E
E
D000368:Aged; D001418:Baclofen / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced*; D006606:Hiccup / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D006435:Renal Dialysis
D009125:Muscle Relaxants, Central; D001418:Baclofen