Effectiveness of early budesonide intervention in Caucasian versus Asian patients with asthma: 3-year results of the START study.
OBJECTIVE
Few studies have assessed the effectiveness of inhaled corticosteroid therapy exclusively in Asian patients with asthma. The present analysis compared the efficacy of early intervention with inhaled budesonide in Caucasian and Asian patients over the first 3 years of the inhaled Steroid Treatment As Regular Therapy in early asthma study.


METHODS
Patients aged 5-66 years with mild persistent asthma of <or=2 years' duration were randomized to 3 years of double-blind treatment with once-daily budesonide 200 microg (for patients aged<11 years) or 400 microg administered via Turbuhaler or placebo, plus usual asthma therapy.


RESULTS
Budesonide significantly improved asthma outcomes in both Caucasian (n=4661) and Asian (n=1995) patients compared with reference therapy (placebo plus usual asthma therapy). Budesonide reduced the risk of a first severe asthma-related event by 42% and 49% in Caucasian and Asian patients, respectively, over the 3-year treatment period (P<0.001 for both). Moreover, budesonide significantly increased symptom-free days, decreased nights with sleeping problems, improved pre- and postbronchodilator FEV1 and reduced the need for additional asthma medications of particular drug classes compared with reference therapy. Except for differences in the patterns of use of additional asthma medications, outcomes with budesonide and overall adverse events were similar in the Caucasian and Asian patient populations.


CONCLUSIONS
Inhaled budesonide administered once daily in Asian patients with recent-onset, mild persistent asthma significantly improved asthma control and pulmonary function compared with reference therapy. Moreover, this effectiveness paralleled that observed in Caucasian patients.
Tan
Wan C
WC
iCapture Centre, UBC, St Paul's Hospital, Vancouver, and Department of Medicine, McMaster University, Hamilton, ON, Canada. wtan@mrl.ubc.ca
Lamm
Carl J
CJ
Chen
Yu-Zhi
YZ
O'Byrne
Paul M
PM
Pedersen
Søren
S
Busse
William W
WW
Ohlsson
Stefan V
SV
Ullman
Anders
A
Andersson
Bertil
B
Pauwels
Romain A
RA
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000188:drug therapy* / Q000208:ethnology* / Q000235:genetics / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019819:Budesonide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006128:Growth / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D016896:Treatment Outcome; D044465:White People / Q000235:genetics
D001993:Bronchodilator Agents; D018343:Receptors, Adrenergic, beta-2; D019819:Budesonide