Choroidal neovascularization with interferon associated retinopathy: case report and review of literature.
We report a case of new interferon-associated ocular complication during treatment with combination of pegylated interferon plus ribavirin for chronic hepatitis C infection. Our patient developed choroidal neovascularization in addition to the classic interferon associated retinopathy. Choroidal neovascularization has not been reported before in association with interferon induced retinopathy. We describe our management to control the ocular symptoms and the retinal lesions with one year follow up. We also provide literature report on the natural history, the pathophysiology and the variable characteristics of interferon associated retinopathy versus hepatitis C related ophthalmopathy.
Bazarah
Salem M
SM
Hepatology Services, Division of Gastroenterology, Dalhousie University, and Capital District Health Authority, Halifax, Nova Scotia, Canada.
Ritenour
Rusty
R
Patel
Sunil T
ST
Hirsch
Geri
G
Peltekian
Kevork M
KM
Cruess
Alan F
AF
D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D020256:Choroidal Neovascularization / Q000139:chemically induced*; D005260:Female; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology; D012196:Review Literature as Topic; D012254:Ribavirin / Q000009:adverse effects / Q000627:therapeutic use
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b