In vitro killing of nosocomial pathogens by acid and acidified nitrite.
Exposure to pH 1 or 2 buffers or acidic gastric contents resulted in the killing of vancomycin-resistant Enterococcus sp., Klebsiella pneumoniae, Staphylococcus aureus, and Candida glabrata but not Clostridium difficile spores. Nitrite enhanced killing under acidic conditions, but significant killing of C. difficile spores required nitrite concentrations above usual physiological levels.
Rao
Agam
A
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA.
Jump
Robin L P
RL
Pultz
Nicole J
NJ
Pultz
Michael J
MJ
Donskey
Curtis J
CJ
D000143:Acids / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology; D002021:Buffers; D041221:Candida glabrata / Q000187:drug effects; D016360:Clostridioides difficile / Q000187:drug effects; D003428:Cross Infection / Q000382:microbiology*; D016983:Enterococcus / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D005744:Gastric Acid / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007711:Klebsiella pneumoniae / Q000187:drug effects; D016106:Methicillin Resistance; D009573:Nitrites / Q000494:pharmacology*; D013172:Spores, Fungal / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D020713:Vancomycin Resistance
D000143:Acids; D002021:Buffers; D009573:Nitrites