title: Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.
abstract: The hemodynamic effects of a series of potent and selective 4-aminopyridine carboxamide-based pan-JNK inhibitors were assessed in an anesthetized rat model. The effects of these agents on mean arterial pressure, heart rate, cardiac contractility, and peripheral vascular resistance are described, and the implication for targeting protein kinases in metabolic diseases is discussed.
authors.affiliation: Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. gang.liu@abbott.com
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhao
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Zhili
authors.initials: Z
authors.lastname: Xin
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Michael D
authors.initials: MD
authors.lastname: Serby
authors.forename: Nathan L
authors.initials: NL
authors.lastname: Lubbers
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Widomski
authors.forename: James S
authors.initials: JS
authors.lastname: Polakowski
authors.forename: David W A
authors.initials: DW
authors.lastname: Beno
authors.forename: James M
authors.initials: JM
authors.lastname: Trevillyan
authors.forename: Hing L
authors.initials: HL
authors.lastname: Sham
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis / Q000494:pharmacology; D000758:Anesthesia; D000777:Anesthetics; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D048670:MAP Kinase Kinase 4 / Q000037:antagonists & inhibitors*; D008297:Male; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000201:enzymology*; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D013874:Thiopental / Q000031:analogs & derivatives; D014655:Vascular Resistance / Q000187:drug effects*; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000631:Aminopyridines; D000777:Anesthetics; D004791:Enzyme Inhibitors; C004316:thiobutabarbital; D048670:MAP Kinase Kinase 4; D013874:Thiopental