title: Antisperm antibodies in prepubertal boys with cryptorchidism.
abstract: The presence of antisperm antibodies in male individuals before puberty is controversial due to the lack of finally differentiated male germ cells. It was questioned whether the pathologic conditions of the male gonad may influence antisperm antibody formation in individuals before puberty. Sera samples of 76 individuals and 10 healthy boys with testicular failure (mainly uni- or bilateral cryptorchidism) were examined by means of indirect immunobead-binding test (IDIBT). The presence of antisperm antibodies was found in 3.95% of the studied subjects. Antibodies recognizing antigenic determinants present on the surface of mature sperm cells may be produced before puberty in individuals suffering from cryptorchidism or the other gonadal disorders. Antisperm antibodies that did develop in a minority of the studied male population may be proof for individual predispositions to autoimmune reactions.
authors.affiliation: Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska, Poznan, Poland.
authors.forename: Alina
authors.initials: A
authors.lastname: Domagala
authors.forename: Anna
authors.initials: A
authors.lastname: Havryluk
authors.forename: Andrij
authors.initials: A
authors.lastname: Nakonechnyj
authors.forename: Marzena
authors.initials: M
authors.lastname: Kamieniczna
authors.forename: Valentina
authors.initials: V
authors.lastname: Chopyak
authors.forename: Maciej
authors.initials: M
authors.lastname: Kurpisz
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D011627:Puberty; D013094:Spermatozoa / Q000276:immunology*
chemical_list: D001323:Autoantibodies