title: The effects of time varying curvature on species transport in coronary arteries.
abstract: Alterations in mass transport patterns of low-density lipoproteins (LDL) and oxygen are known to cause atherosclerosis in larger arteries. We hypothesise that the species transport processes in coronary arteries may be affected by their physiological motion, a factor which has not been considered widely in mass transfer studies. Hence, we numerically simulated the mass transport of LDL and oxygen in an idealized moving coronary artery model under both steady and pulsatile flow conditions. A physiological inlet velocity and a sinusoidal curvature waveform were specified as velocity and wall motion boundary conditions. The results predicted elevation of LDL flux, impaired oxygen flux and low wall shear stress (WSS) along the inner wall of curvature, a predilection site for atherosclerosis. The wall motion induced changes in the velocity and WSS patterns were only secondary to the pulsatile flow effects. The temporal variations in flow and WSS due to the flow pulsation and wall motion did not affect temporal changes in the species wall flux. However, the wall motion did alter the time-averaged oxygen and LDL flux in the order of 26% and 12% respectively. Taken together, these results suggest that the wall motion may play an important role in coronary arterial transport processes and emphasise the need for further investigation.
authors.affiliation: School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK.
authors.forename: Maheshwaran K
authors.initials: MK
authors.lastname: Kolandavel
authors.forename: Ernst-Torben
authors.initials: ET
authors.lastname: Fruend
authors.forename: Steffen
authors.initials: S
authors.lastname: Ringgaard
authors.forename: Peter G
authors.initials: PG
authors.lastname: Walker
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D003198:Computer Simulation; D003324:Coronary Artery Disease / Q000378:metabolism / Q000503:physiopathology; D003331:Coronary Vessels / Q000502:physiology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008955:Models, Cardiovascular; D010100:Oxygen / Q000378:metabolism*; D011673:Pulsatile Flow / Q000502:physiology
chemical_list: D008077:Lipoproteins, LDL; D010100:Oxygen