A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusion.
We herein describe a 4-year-old boy who after being treated for pneumonia showed an abnormal shadow at the hilus of the right lung on chest X-rays with continued inflammatory findings in his laboratory data. CT and MR investigations suggested the existence of a neoplasm at that site. An open biopsy was thus performed for a definite diagnosis. The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor. A right upper and middle lobectomy including the tumor was thus performed for a complete resection. In addition to the histological diagnosis, the detection of the tumor specific fusion gene provided objective evidence in making a diagnosis.
Kinoshita
Y
Y
Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. kinoppy@pedsurg.med.kyushu-u.ac.jp
Tajiri
T
T
Ieiri
S
S
Nagata
K
K
Taguchi
T
T
Suita
S
S
Yamazaki
K
K
Yoshino
I
I
Maehara
Y
Y
Kohashi
K
K
Yamamoto
H
H
Oda
Y
Y
Tsuneyoshi
M
M
D000077548:Anaplastic Lymphoma Kinase; D002675:Child, Preschool; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases; D014335:Tropomyosin / Q000235:genetics*
D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm; C498783:TPM3 protein, human; D014335:Tropomyosin; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases