title: Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension.
abstract: BACKGROUND
  The purpose of the study was to use factor analysis to investigate the contribution of a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), to a clustering of cardiovascular risk factors in hypertensive subjects.
  
  
  METHODS
  A total of 204 nondiabetic hypertensive patients who received IST for SSPG were included for current analysis. Factor analysis was performed to explore the contribution of SSPG as additional information to a clustering of risk factors in these subjects.
  
  
  RESULTS
  In factor analysis, SSPG aggregated with metabolic variables in an obesity-hyperinsulinemia domain that included two factors: one with positive loadings for SSPG, 2-h glucose, and Log 2-h insulin; and the other with positive loadings for body mass index, waist circumference, and fasting glucose. Fasting insulin linked the two factors together and explained 38.3% of the total variance. Systolic and diastolic blood pressures were loaded on a blood pressure domain separately. The third domain consisted of two factors: one with positive loadings for Log triglycerides and negative loading for high-density lipoprotein cholesterol; and the other with positive loadings for Log triglycerides and non-high-density lipoprotein cholesterol. The model loaded without SSPG explained a proportion of the total variance (78.5%) similar to that achieved with the model loaded with SSPG (77.1%).
  
  
  CONCLUSIONS
  Directly measured insulin sensitivity index SSPG clustered with 2-h glucose and Log 2-h insulin in factor analysis in a cohort consisting entirely of hypertensive subjects. However, the contribution of SSPG as additional information to explain the total variance seems to be insignificant.
authors.affiliation: Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Lin
authors.forename: Chii-Min
authors.initials: CM
authors.lastname: Hwu
authors.forename: Yung-Hsiang
authors.initials: YH
authors.lastname: Huang
authors.forename: Wayne H-H
authors.initials: WH
authors.lastname: Sheu
authors.forename: Kuang-Chung
authors.initials: KC
authors.lastname: Shih
authors.forename: Fu-Tien
authors.initials: FT
authors.lastname: Chiang
authors.forename: Richard
authors.initials: R
authors.lastname: Olshen
authors.forename: Yii-Der I
authors.initials: YD
authors.lastname: Chen
authors.forename: J David
authors.initials: JD
authors.lastname: Curb
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rodriguez
authors.forename: Low-Tone
authors.initials: LT
authors.lastname: Ho
mesh_terms: D000328:Adult; D001213:Asian; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D002320:Cardiovascular Physiological Phenomena; D015331:Cohort Studies; D005163:Factor Analysis, Statistical; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D001786:Blood Glucose