Controlled drug delivery system based on magnetic hollow spheres/polyelectrolyte multilayer core-shell structure.
A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a "Layer-by-Layer" (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core-shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core-shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics.
Zhang
YanQi
Y
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China.
Lil
LinLin
L
Tang
Fangqiong
F
Ren
Jun
J
D000180:Acrylic Resins / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry; D002515:Cephradine / Q000008:administration & dosage / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry; D008280:Magnetics / Q000627:therapeutic use*; D008863:Microspheres; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004573:Electrolytes; C006903:carbopol 940; D048271:Chitosan; D002515:Cephradine