Circulating gastrin is increased in hemochromatosis.
Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively. Since non-amidated gastrins require ferric ions for biological activity in vitro, this study investigated the connection between iron status and gastrin by measurement of circulating gastrin concentrations in mice and humans with hemochromatosis. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe(-/-) mice, and in the sera of humans with HFE-related hemochromatosis. The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis.
Smith
Kelly A
KA
University of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, Vic. 3084, Australia.
Kovac
Suzana
S
Anderson
Gregory J
GJ
Shulkes
Arthur
A
Baldwin
Graham S
GS
D000818:Animals; D005753:Gastric Mucosa / Q000737:chemistry; D005755:Gastrins / Q000032:analysis / Q000097:blood* / Q000302:isolation & purification; D005998:Glycine; D006432:Hemochromatosis / Q000097:blood* / Q000378:metabolism; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D007501:Iron / Q000097:blood / Q000502:physiology; D008565:Membrane Proteins / Q000172:deficiency / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout
D005755:Gastrins; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; C499535:Hfe protein, mouse; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D007501:Iron; D005998:Glycine