[Src protein tyrosine kinase family and acute lung injury].
Acute inflammatory responses are one of the major underlying mechanisms for tissue damage of multiple diseases, such as sepsis and acute lung injury. Inflammatory mediators released from a variety of cells in response to acute inflammations can interact with immune cells, microvascular endothelial cells and other tissue cells, to elicit a series of intracellular signaling reactions where activation of Src protein tyrosine kinase (PTK) family members is involved. Using cellular and molecular approaches and transgenic animals, Src PTK family members have been identified to be essential for the recruitment and activation of monocytes, macrophages, neutrophils and other immune cells. Src PTK family members also play a critical role in the regulation of vascular permeability and inflammatory responses in tissue cells. Importantly, animal studies have demonstrated that small chemical inhibitors for Src PTKs attenuated acute lung injury. Further investigation may lead to the clinical application of these inhibitors as drugs for acute lung injury.
Okutani
Daisuke
D
Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry.
D000818:Animals; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D015398:Signal Transduction; D019061:src-Family Kinases / Q000502:physiology*
D011505:Protein-Tyrosine Kinases; D019061:src-Family Kinases