Blood coagulation unaffected by ozonated autohemotherapy in patients on maintenance hemodialysis.
BACKGROUND
Ozonated autohemotherapy (O(3)-AHT) is a clinically useful therapeutic procedure in hemodialyzed patients with peripheral arterial occlusive disease (PAOD). The majority of patients on dialysis are in a hypercoagulable state. Thrombotic complications are the major cause of morbidity and mortality in hemodialyzed patients. Effects of O(3)-AHT on blood coagulation were evaluated in 11 hemodialyzed patients affected by PAOD.


METHODS
We performed an oxygen-controlled, crossover study in which nine sessions of autohemotherapy with oxygen administration (AHT) as a control were followed by nine sessions of O(3)-AHT. Blood coagulation was assessed by antithrombin III, activated partial thromboplastin time, prothrombin time, D-dimer and fibrinogen plasma concentrations.


RESULTS
The extents of all the measured parameters after nine sessions of O(3)-AHT did not differ statistically from the values after nine sessions of AHT. Similarly, there were no differences in the measured variables after the first session of O(3)-AHT as compared to the values before therapy. We did not observe any thrombotic accidents during the study.


CONCLUSIONS
O(3)-AHT with ozone concentration of 50 microg/mL and citrate as an anticoagulant does not influence blood coagualation parameters in hemodialyzed patients with PAOD.
Biedunkiewicz
Bogdan
B
Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
Lizakowski
Slawomir
S
Tylicki
Leszek
L
Skiboeska
Anna
A
Nieweglowski
Tomas
T
Chamienia
Andrzej
A
Debska-Slizien
Alicja
A
Rutkowski
Boleslaw
B
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000628:therapy*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001804:Blood Transfusion, Autologous / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000627:therapeutic use*; D016491:Peripheral Vascular Diseases / Q000188:drug therapy / Q000628:therapy*; D006435:Renal Dialysis; D017211:Treatment Failure
D010126:Ozone