title: FDG PET/CT demonstrates the effectiveness of isolated limb infusion for malignant melanoma.
abstract: A 43-year-old woman presented with a nodular melanoma treated with wide excision, split skin graft, and sentinel node biopsy. At 2-year follow up, she was noted to have clinical recurrence at the excision site. FDG PET/CT demonstrated in-transit metastasis in her left thigh in addition to disease at the site of the sentinel node biopsy. Isolated limb infusion was performed with melphalan and dactinomycin. PET/CT at 5 weeks demonstrated resolution of the in-transit metastasis and the disease at the excision site. This report of PET/CT demonstrates the effectiveness of chemotherapy for malignant melanoma delivered by isolated limb infusion.
authors.affiliation: St. Vincent's University Hospital, Department of Radiology, Dublin, Ireland. ronan@ronanryan.com
authors.forename: E Ronan
authors.initials: ER
authors.lastname: Ryan
authors.forename: Arnold D K
authors.initials: AD
authors.lastname: Hill
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Skehan
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003609:Dactinomycin / Q000008:administration & dosage; D019788:Fluorodeoxyglucose F18; D007261:Infusions, Intra-Arterial; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000175:diagnosis* / Q000188:drug therapy* / Q000556:secondary; D008558:Melphalan / Q000008:administration & dosage; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000556:secondary; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D003609:Dactinomycin; D008558:Melphalan