title: Microdamage and bone mechanobiology.
abstract: Mechanobiology is concerned with the relationships between mechanical forces and biological processes. Bone adapts to altered mechanical loading by modelling and remodelling. Microdamage is a stimulus for adaptation as shown by a sheep overload model. If microdamage accumulates it leads to fracture failure, notably in osteoporosis. Detection methods, based on chelating fluorochromes and radiopaque agents, will enable microdamage to be quantified and, along with bone mass, aid in fracture prediction and prevention. Mechanobiological principles can be utilised to create tissue engineered bone grafts in cases of bone loss due to trauma, malignancy or resorption.
authors.affiliation: Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland. tclee@rcsi.ie
authors.forename: T C
authors.initials: TC
authors.lastname: Lee
authors.forename: F J
authors.initials: FJ
authors.lastname: O'Brien
authors.forename: T
authors.initials: T
authors.lastname: Gunnlaugsson
authors.forename: R
authors.initials: R
authors.lastname: Parkesh
authors.forename: D
authors.initials: D
authors.lastname: Taylor
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D001696:Biomechanical Phenomena; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000293:injuries / Q000473:pathology*; D019245:Compressive Strength; D003238:Connective Tissue; D050723:Fractures, Bone / Q000209:etiology*; D015775:Fractures, Stress / Q000209:etiology*; D006801:Humans; D008954:Models, Biological; D010024:Osteoporosis / Q000473:pathology*; D013314:Stress, Mechanical; D023822:Tissue Engineering; D016474:Weight-Bearing / Q000502:physiology*