title: Identification of a hormonal basis for gallbladder filling.
abstract: The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
authors.forename: Mihwa
authors.initials: M
authors.lastname: Choi
authors.forename: Antonio
authors.initials: A
authors.lastname: Moschetta
authors.forename: Angie L
authors.initials: AL
authors.lastname: Bookout
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.forename: Michihisa
authors.initials: M
authors.lastname: Umetani
authors.forename: Sam R
authors.initials: SR
authors.lastname: Holmstrom
authors.forename: Kelly
authors.initials: K
authors.lastname: Suino-Powell
authors.forename: H Eric
authors.initials: HE
authors.lastname: Xu
authors.forename: James A
authors.initials: JA
authors.lastname: Richardson
authors.forename: Robert D
authors.initials: RD
authors.lastname: Gerard
authors.forename: David J
authors.initials: DJ
authors.lastname: Mangelsdorf
authors.forename: Steven A
authors.initials: SA
authors.lastname: Kliewer
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000097:blood; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology*; D005704:Gallbladder / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D012333:RNA, Messenger; C108526:fibroblast growth factor 15, mouse; D005346:Fibroblast Growth Factors; D002766:Cholecystokinin; D000242:Cyclic AMP; D006152:Cyclic GMP