title: Screening for motility-associated genes in malignant astrocytoma cell lines.
abstract: The most characteristic feature of a malignant astrocytoma is its early and extensive infiltration into adjacent parenchymal structures. We focused on detecting the possible expression changes as the determining factors for malignant astrocytoma's motile ability. We confirmed that four of 39 genes showed different expression on DD-PCR by RT-PCR and Northern blot analysis. These findings suggest that the genes identified may be important for determining high motility in astrocytoma cell lines. These findings may help us understand the molecular invasion mechanism in astrocytomas.
authors.affiliation: Brain Tumor Research Laboratory, Medical School, Chonnam National University, Gwangju, and Department of Neurosurgery, Chonnam National University Hwasun Hospital, Jeollanam-do, Republic of Korea.
authors.forename: Hyang-Hwa
authors.initials: HH
authors.lastname: Ryu
authors.forename: Shin
authors.initials: S
authors.lastname: Jung
authors.forename: Heung-Suk
authors.initials: HS
authors.lastname: Sun
authors.forename: Tae-Young
authors.initials: TY
authors.lastname: Jung
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Jin
authors.forename: Yong-Hao
authors.initials: YH
authors.lastname: Jin
authors.forename: In-Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Jeong
authors.forename: Sam-Suk
authors.initials: SS
authors.lastname: Kang
mesh_terms: D001254:Astrocytoma / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D002465:Cell Movement; D020869:Gene Expression Profiling; D006801:Humans; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor