Serotonin transporter and dopamine transporter imaging in the canine brain.
The serotonergic and dopaminergic systems are involved in a wide range of emotional and behavioral aspects of animals and humans and are involved in many neuropsychiatric disorders. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are designed to block the 5-HT transporter (SERT), thereby increasing the available 5-HT in the brain. Functional imaging with specific SERT and dopamine transporter (DAT) ligands contributes to the study of the SSRI-transporter interaction. First, we evaluated the feasibility of a canine model in the study of the SERT and DAT with the radioligands [123I]-beta-CIT and [123I]-FP-CIT as well as single-photon emission computed tomography imaging. Second, we studied the effect of SSRIs (sertraline, citalopram and escitalopram) on the SERT and DAT in two dogs. The position of the canine model in the study of the SERT and DAT is discussed and compared with other animal models.
Peremans
Kathelijne
K
Department of Medical Imaging, Faculty of Veterinary Sciences, Ghent University, B-9000 Ghent, Belgium.
Goethals
Ingeborg
I
De Vos
Filip
F
Dobbeleir
A
A
Ham
Hamphrey
H
Van Bree
Henri
H
Van Heeringen
Cees
C
Audenaert
Kurt
K
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D003042:Cocaine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004285:Dogs; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005240:Feasibility Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D014326:Tropanes / Q000493:pharmacokinetics*
D050483:Dopamine Plasma Membrane Transport Proteins; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine