Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling.
Membrane lipids function as structural molecules, reservoirs for second messengers, membrane platforms that scaffold protein assembly and regulators of enzymes and ion channels. Such diverse lipid functions contribute substantially to cellular mechanisms for fine-tuning membrane-signaling events. Meaningful coordination of these events requires exquisite spatial and temporal control of lipid metabolism and organization, and reliable mechanisms for specifically coupling these parameters to dedicated physiological processes. Recent studies suggest such integration is linked to the action of phosphatidylinositol transfer proteins that operate at the interface of the metabolism, trafficking and organization of specific lipids.
Ile
Kristina E
KE
Department of Cell & Developmental Biology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7090, USA.
Schaaf
Gabriel
G
Bankaitis
Vytas A
VA
D000595:Amino Acid Sequence; D000818:Animals; D017360:Arabidopsis / Q000235:genetics; D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry*; D049294:Phospholipid Transfer Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D012441:Saccharomyces cerevisiae / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology
D008563:Membrane Lipids; D049294:Phospholipid Transfer Proteins