[Study on relative bioavailability of ferulic acid of combination Radix Angelicae Sinensis and Cortex Cinnamomi in mice].
OBJECTIVE
To study the phamacokinetics and relative bioavailability of combination Radix Angelicae Sinensis and Cortex Cinnamomi.


METHODS
The content of ferulic acid in plasma was determined directly by HPLC after oral administration of Cortex Cinnamomi in combination individually with Radix Angelicae Sinensis. The plasma concentration-time curve were plotted. The main pharmacokinetic parameters and relative bioavailability were obtained.


RESULTS
The plasma concentration-time curve of fenalic aclid conformed to one-compartment model. The relative bioavailability of Cortex Cinnamomi combined with Radix Angelicae Sinensis were 226.75%.


CONCLUSIONS
By the statistical analysis, Cortex Cinnamomi combined with Radix Angelicae Sinensis can increase the relative bioavailability of ferulic acid.
Yang
Zu-yi
ZY
Sichuan Cancer Institute, Chengdu 610041, China.
Pei
Jin
J
Liu
Rong-min
RM
Cheng
Jia
J
Wan
De-guang
DG
Hu
Rong
R
D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D001682:Biological Availability; D032904:Cinnamomum aromaticum / Q000737:chemistry; D003373:Coumaric Acids / Q000097:blood / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D003373:Coumaric Acids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C004999:ferulic acid