title: Maintaining urine production and early allograft function during laparoscopic donor nephrectomy.
abstract: OBJECTIVE
  Intraoperative oliguria and its impact on early postoperative allograft function have been expressed as potential concerns of laparoscopic kidney donation. We evaluated our ability to maintain adequate diuresis during laparoscopic donor nephrectomy and its potential impact on early graft function compared with open donation.
  
  
  METHODS
  We performed a retrospective review of 98 laparoscopic and 80 open donor nephrectomies from 1999 to 2002. All laparoscopic donors received infusions of mannitol (grams of mannitol equaled patient weight in kilograms) and dopamine (2 to 3.0 microg/kg/min) throughout the pneumoperitoneum. All open donors received a single dose of mannitol (12.5 g). Multiple donor variables were compared, including operative time, estimated blood loss, intraoperative fluid administration (in milliliters per kilogram per hour), intraoperative urine production (milliliters per kilogram per hour), and change in creatinine at discharge. The postoperative recipient data were compared, including initial 24-hour urine output, 1-week creatinine level, 1-month creatinine level, and need for postoperative hemodialysis.
  
  
  RESULTS
  No significant differences were noted in the donor groups with respect to age, weight, intraoperative fluid administration, or change in creatinine at discharge. The mean operative urine production was greater in the laparoscopic group at 5.22 mL/kg/hr than in the open group at 2.43 mL/kg/hr (P = 0.0001). The mean estimated blood loss was significantly lower (P = 0.0001) for the laparoscopic donors (106.7 mL) than for the open donors (184.7 mL). No significant differences were seen among the recipient groups.
  
  
  CONCLUSIONS
  The use of mannitol and dopamine infusions during laparoscopic donor nephrectomy provided superior intraoperative urine production in the donor and equivalent early graft function in the recipient compared with the open approach.
authors.affiliation: Department of Surgery, Division of Transplant Surgery, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA.
authors.forename: Stefanie L
authors.initials: SL
authors.lastname: Bolte
authors.forename: L Thomas
authors.initials: LT
authors.lastname: Chin
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Moon
authors.forename: Anthony M
authors.initials: AM
authors.lastname: D'Alessandro
authors.forename: Stephen Y
authors.initials: SY
authors.lastname: Nakada
authors.forename: Yolanda T
authors.initials: YT
authors.lastname: Becker
authors.forename: Sean P
authors.initials: SP
authors.lastname: Hedican
mesh_terms: D000328:Adult; D051799:Delayed Graft Function / Q000517:prevention & control*; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D006801:Humans; D016030:Kidney Transplantation; D010535:Laparoscopy; D019520:Living Donors; D008353:Mannitol / Q000494:pharmacology; D009392:Nephrectomy / Q000379:methods*; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D014556:Urine
chemical_list: D004232:Diuretics; D008353:Mannitol; D004298:Dopamine