title: [Effect of zhigancao decoction containing serum on transient outward potassium current in isolated single ventricular myocyte of rabbits].
abstract: OBJECTIVE
  To investigate the effect of Zhigancao Decoction (ZD) containing serum on transient outward potassium current (I(to)) in isolated single ventricular myocyte of rabbits.
  
  
  METHODS
  Single rabbit ventricular myocytes were isolated and divided into 6 groups, the normal group, the non-drug-containing serum group, and the ZD groups, they were treated with normal extracellular fluid alone or with ZD containing serum recording technique was used to observe the changes of I(to).
  
  
  RESULTS
  After treated with 5%, 10%, 20% and 40% ZD containing serum, the I(to) was inhibited and its peak value dropped from (16.1 +/- 1.4) PA/PF to (13.9 +/-1.5) PA/PF, (11.8 +/- 1.9) PA/PF, (8.3 +/- 1.5) PA/PF and (8.2 +/- 1.2) PA/PF respectively, and the effect could be eliminated by elution.
  
  
  CONCLUSIONS
  ZD containing serum could inhibit the I(to) in isolated ventricular myocytes of rabbits in a concentration-dependent manner, which may be the mechanism of antiarrhythmic action of ZI).
authors.affiliation: Department of Cardiology, Cardiology, Hubei Provincial Hospital of TCM, Wuhan. acheng8341@mail.china.com
authors.forename: Cheng-zhi
authors.initials: CZ
authors.lastname: Zhou
authors.forename: Dao-liang
authors.initials: DL
authors.lastname: Zhang
authors.forename: Teng
authors.initials: T
authors.lastname: Wang
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004594:Electrophysiology; D006352:Heart Ventricles / Q000166:cytology; D008297:Male; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015221:Potassium Channels / Q000378:metabolism*; D011817:Rabbits; D011897:Random Allocation; D044967:Serum
chemical_list: D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal; D015221:Potassium Channels; C526719:zhigancao decoction