Complexes of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin. A study of their antimicrobial activity.
Cobalt(II), nickel(II), copper(II) and zinc(II) complexes of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin (HL(1) and HL(2), respectively) were synthesized and characterized, being the crystal structures of HL(1), HL(2) and [Ni(L(1))(2)].2CHCl(3) elucidated by X-ray diffraction techniques. The in vitro antimicrobial activity of all these compounds was tested against several bacteria and fungi. HL(1)and its complexes exhibited a strong inhibition of the growth of Haemophilus influenzae (MIC 0.15-1.50microg/mL) and good antibacterial properties towards Bacillus subtilis (MIC 3-25microg/mL). The minimal inhibitory concentration (MIC) was defined as the lowest concentration of compound inhibiting the growth of each strain. The antibacterial effectiveness was confirmed against a number of Gram positive bacteria, including methicillin-resistant Staphylococcus aureus. Yeasts and moulds showed a low susceptibility, except the dermatophyte mould Epidermophyton floccosum that is inhibited at concentrations ranging from 6 to 50microg/mL. In general, the antimicrobial activity of the thiophene derivatives was greater than that of the isonicotinic analogues.
Rodríguez-Argüelles
María C
MC
Departamento de Química Inorgánica, Universidade de Vigo, 36200 Vigo, Spain. mcarmen@uvigo.es
Mosquera-Vázquez
Sandra
S
Tourón-Touceda
Patricia
P
Sanmartín-Matalobos
Jesús
J
García-Deibe
Ana M
AM
Belicchi-Ferrari
Marisa
M
Pelosi
Giorgio
G
Pelizzi
Corrado
C
Zani
Franca
F
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D006835:Hydrazones; D007211:Indoles; D013876:Thiophenes; C095912:N-methylisatin