title: Use of a new method in reaching consensus on the cause of cytologic-histologic correlation discrepancy.
abstract: Pathologists exhibit very poor agreement in adjudicating the cause of cytologic-histologic correlation discrepancies, which contributes to problems in designing interventions to reduce discrepancy frequency. In this observational study, we developed a visual method of adjudicating discrepancy cause, termed the No-Blame Box method, which consisted of initially assessing specimen interpretability by separately evaluating specimen quality and the presence of tumor. Five pathologists blindly adjudicated the cause of discrepancy in pulmonary specimens from 40 patients. The kappa statistic of all pathologist pairs in adjudicating discrepancy cause using the No-Blame Box method ranged from 0.400 to 0.796, indicating acceptable to excellent agreement. Pathologists ranged in their assessment of specimen interpretability from 13% to 20%, and in no case did all 5 pathologists concur that a specimen was interpretable. Most discrepancies resulted from pathologists diagnosing noninterpretable samples. Pathologists who used the No-Blame Box showed significant agreement in the adjudication of discrepancy cause.
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Raab
authors.forename: Chad H
authors.initials: CH
authors.lastname: Stone
authors.forename: Eva M
authors.initials: EM
authors.lastname: Wojcik
authors.forename: Kim R
authors.initials: KR
authors.lastname: Geisinger
authors.forename: Laila
authors.initials: L
authors.lastname: Dahmoush
authors.forename: Fernando U
authors.initials: FU
authors.lastname: Garcia
authors.forename: Dana Marie
authors.initials: DM
authors.lastname: Grzybicki
authors.forename: Janine E
authors.initials: JE
authors.lastname: Janosky
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Meier
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Zarbo
mesh_terms: D032921:Consensus; D003951:Diagnostic Errors; D006801:Humans; D015233:Models, Statistical; D015588:Observer Variation; D010340:Pathology, Surgical / Q000379:methods* / Q000592:standards; D011785:Quality Assurance, Health Care / Q000379:methods*; D015203:Reproducibility of Results; D016037:Single-Blind Method