title: A review: synthesis of aryl C-glycosides via the heck coupling reaction.
abstract: In this article, we focus on the synthesis of aryl C-glycosides via Heck coupling. It is organized based on the type of structures used in the assembly of the C-glycosides (also called C-nucleosides) with the following subsections: pyrimidine C-nucleosides, purine C-nucleosides, and monocyclic, bicyclic, and tetracyclic C-nucleosides. The reagents and conditions used for conducting the Heck coupling reactions are discussed. The subsequent conversion of the Heck products to the corresponding target molecules and the application of the target molecules are also described.
authors.affiliation: Foundation for Applied Molecular Evolution, Gainesville, Florida 32604, USA.
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Wellington
authors.forename: Steven A
authors.initials: SA
authors.lastname: Benner
mesh_terms: D002621:Chemistry / Q000379:methods*; D016207:Cytokines / Q000737:chemistry; D005821:Genetic Techniques; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology
chemical_list: D016207:Cytokines; D006027:Glycosides; D009705:Nucleosides; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors