title: Topical delivery of silver nanoparticles promotes wound healing.
abstract: Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.
authors.affiliation: Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tian
authors.forename: Kenneth K Y
authors.initials: KK
authors.lastname: Wong
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Ho
authors.forename: Chun-Nam
authors.initials: CN
authors.lastname: Lok
authors.forename: Wing-Yiu
authors.initials: WY
authors.lastname: Yu
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
authors.forename: Jen-Fu
authors.initials: JF
authors.lastname: Chiu
authors.forename: Paul K H
authors.initials: PK
authors.lastname: Tam
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016207:Cytokines / Q000378:metabolism; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D012834:Silver / Q000008:administration & dosage*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D016207:Cytokines; D012834:Silver