title: Cytotoxic resveratrol oligomers from the tree bark of Dipterocarpus hasseltii.
abstract: A new resveratrol tetramer, named diptoindonesin E, was isolated from the acetone extract of the tree bark of Dipterocarpus hasseltii, together with five known resveratrol oligomers (-)-epsilon-viniferin, laevifonol, (-)-alpha-viniferin, vaticanol B, (-)-hopeaphenol, and a coumarin, scopoletin. The structures of these compounds were determined from spectroscopic evidence. Cytotoxicity test of the isolated compounds showed that hopeaphenol strongly inhibited murine leukemia P-388 cells.
authors.affiliation: Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.
authors.lastname: Muhtadi
authors.forename: Euis H
authors.initials: EH
authors.lastname: Hakim
authors.forename: Lia D
authors.initials: LD
authors.lastname: Juliawaty
authors.forename: Yana M
authors.initials: YM
authors.lastname: Syah
authors.forename: Sjamsul A
authors.initials: SA
authors.lastname: Achmad
authors.forename: Jalifah
authors.initials: J
authors.lastname: Latip
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Ghisalberti
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D020448:Ericales; D051379:Mice; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D013267:Stilbenes; C516745:diptoindonesin E; D000077185:Resveratrol