[Transvaginal color doppler ultrasonography and CA125 detection in surveillance of ovarian malignant tumors after operation].
OBJECTIVE
Although transvaginal ultrasonography color Doppler flow imaging (TV-CDFI) has been widely applied in ultrasonography diagnosis, studies on TV-CDFI combined with a serum tumor marker CA125 detection in the surveillance of ovarian malignant tumors after operation are few. This study was to evaluate TV-CDFI combined with CA125 detection in the surveillance of ovarian malignant tumors after operation.


METHODS
Sixty-two cases of ovarian malignant tumors after operation were examined by TV-CDFI. The level of CA125 was measured, and the results were evaluated compared with pathologic findings. The diagnostic sensitivity, specificity, and accuracy were calculated.


RESULTS
The diagnostic sensitivity of TV-CDFI or CA125 alone was 84.6% and 65.4%; the specificity was 88.9% and 66.7%; the accuracy was 87.1% and 66.1%. While the diagnostic sensitivity of TV-CDFI combined with CA125 was 92.3%, the specificity was 88.9%, and the accuracy rate rose to 90.3% (P<0.05).


CONCLUSIONS
The diagnostic accuracy for recurrent ovarian malignant tumors is improved by TV-CDFI combined with CA125, which is more helpful in the surveillance of recurrent ovary malignant tumors than TV-CDFI alone.
Zeng
Hui
H
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China. gzzeng@163.com
Pei
Xiao-Qing
XQ
Zheng
Dan-Miao
DM
Zhao
Yan-Li
YL
Chen
Xiao-Yue
XY
D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D018282:Cystadenocarcinoma, Mucinous / Q000276:immunology / Q000601:surgery; D018284:Cystadenocarcinoma, Serous / Q000276:immunology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D010051:Ovarian Neoplasms / Q000276:immunology / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color
D018394:CA-125 Antigen