title: Tissue engineering for tendon repair.
abstract: Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.
authors.affiliation: Institute of Science and Technology in Medicine, Keele University, Hartshill, UK.
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Bagnaninchi
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: El Haj
authors.forename: Nicola
authors.initials: N
authors.lastname: Maffulli
mesh_terms: D001672:Biocompatible Materials; D005260:Female; D006801:Humans; D008297:Male; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures / Q000379:methods*; D012038:Regeneration / Q000502:physiology; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D052256:Tendinopathy / Q000601:surgery; D013708:Tendon Injuries / Q000601:surgery*; D013710:Tendons / Q000502:physiology / Q000601:surgery*; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials