title: Mesoporous silica material TUD-1 as a drug delivery system.
abstract: For the first time the feasibility of siliceous mesoporous material TUD-1 (Technische Universiteit Delft) for drug delivery was studied. Model drug, ibuprofen, was adsorbed into TUD-1 mesopores via a soaking procedure. Characterizations with nitrogen adsorption, XRD, TG, HPLC and DSC demonstrated the successful inclusion of ibuprofen into TUD-1 host. The amount of ibuprofen adsorbed into the nanoreservoir of TUD-1 material was higher than reported for other mesoporous silica drug carriers (drug/carrier 49.5 wt.%). Drug release studies in vitro (HBSS buffer pH 5.5) demonstrated a fast and unrestricted liberation of ibuprofen, with 96% released at 210 min of the dissolution assay. The drug dissolution profile of TUD-1 material with the random, foam-like three-dimensional mesopore network and high accessibility to the dissolution medium was found to be much faster (kinetic constant k = 10.7) and more diffusion based (release constant n = 0.64) compared to a mesoporous MCM-41 material with smaller, unidirectional mesopore channels (k = 4.7, n = 0.71). Also, the mesoporous carriers were found to significantly increase the dissolution rate of ibuprofen, when compared to the pure crystalline form of the drug (k = 0.6, n = 0.96). TUD-1 was constituted as a potential drug delivery device with fast release property, with prospective applications in the formulation of poorly soluble drug compounds.
authors.affiliation: Laboratory of Industrial Physics, Department of Physics, University of Turku, FI-20014 Turku, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Heikkilä
authors.forename: J
authors.initials: J
authors.lastname: Salonen
authors.forename: J
authors.initials: J
authors.lastname: Tuura
authors.forename: M S
authors.initials: MS
authors.lastname: Hamdy
authors.forename: G
authors.initials: G
authors.lastname: Mul
authors.forename: N
authors.initials: N
authors.lastname: Kumar
authors.forename: T
authors.initials: T
authors.lastname: Salmi
authors.forename: D Yu
authors.initials: DY
authors.lastname: Murzin
authors.forename: L
authors.initials: L
authors.lastname: Laitinen
authors.forename: A M
authors.initials: AM
authors.lastname: Kaukonen
authors.forename: J
authors.initials: J
authors.lastname: Hirvonen
authors.forename: V-P
authors.initials: VP
authors.lastname: Lehto
mesh_terms: D000327:Adsorption; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000032:analysis / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; C509968:MCM-41; D012822:Silicon Dioxide; D007052:Ibuprofen