BMP4 expression in the developing rat retina.
We investigated the expression of bone morphogenetic protein-4 (BMP4) in the developing retina. At E19, we found very intense BMP4 immunoreactivity (IR) in the nerve fiber layer. At P1, the inner plexiform layer exhibited very strong BMP4-IR. Thereafter, abundant BMP4 expression was kept to the adult period. These results suggest that BMP4 plays pivotal roles in the retina not only in the early embryonic period but also in the late embryonic and postnatal periods, and even in the adult.
Maruyama
Yuka
Y
Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Mikawa
Sumiko
S
Hotta
Yoshihiro
Y
Sato
Kohji
K
D000818:Animals; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000166:cytology / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D014018:Tissue Distribution
C525811:Bmp4 protein, rat; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins