Adult male rats sub-chronically exposed to diphenyl diselenide: Effects on their progeny.
The present study was conducted to evaluate the toxicity of diphenyl diselenide [(PhSe)2] exposure on the progeny of Wistar male rats. Male rats were exposed to (PhSe)2 subcutaneously for 4 weeks at the dose of 5.0 mg/kg and 8 weeks at the dose of 2.5 mg/kg, prior to mating with unexposed females. No lethality was noted in any group. At term of exposure period, 4-week exposed male rats presented significant decrease in the body weight. Sex organ weights were similar in (PhSe)2-exposed and control male groups. The number of implantation sites in females mated with males exposed to (PhSe)2 for 8 weeks was significantly higher than those of the respective control group. Male exposure to (PhSe)2, administered for 4 and 8 weeks, did not change fetal body weight. Gross examination of fetuses from 4- to 8-week exposed groups did not reveal the appearance of external anomalies. Examination of live fetuses for ossification centers did not show significantly difference between groups. No increase in the incidence of skeletal anomalies was observed in fetuses obtained from females impregnated with (PhSe)2-exposed males. The current study indicated that (PhSe)2 given sub-chronically (4 or 8 weeks) to male rats had no adverse effects on their progeny.
Favero
Alexandre Marafon
AM
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, SM, CEP 97105-900 Santa Maria, RS, Brazil.
Weis
Simone Nardin
SN
Stangherlin
Eluza Curte
EC
Zeni
Gilson
G
Rocha
Joao Batista Teixeira
JB
Nogueira
Cristina Wayne
CW
D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D047109:Fetal Development / Q000187:drug effects; D007279:Injections, Subcutaneous; D008297:Male; D009929:Organ Size / Q000187:drug effects; D016566:Organoselenium Compounds / Q000633:toxicity*; D018812:Paternal Exposure; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects / Q000473:pathology; D018675:Toxicity Tests
D001555:Benzene Derivatives; D004785:Environmental Pollutants; D016566:Organoselenium Compounds; C061132:diphenyldiselenide