title: [Epithelioid hemangioendothelioma of bone].
abstract: Epithelioid hemangioendothelioma is a low-grade malignant tumor with a histologic appearance and clinical course between that of a hemangioma and angiosarcoma. It is rarely encountered in the bone. A 48-year-old woman was examined following trauma. A cystic lesion was noted on a plain radiograph of the left foot, destructing the diaphysis of the first metatarsal bone. Magnetic resonance imaging showed a solid intramedullary lesion involving a large part of the bone. Scintigraphic examination showed uptake in the diaphysis of the left tibia and the first metatarsal bone of the left foot. Histopathologic examination showed a neoplastic lesion consisting of atypical endothelial cells lining vascular structures or forming solid nests in a myxoid stroma. The tumor was immunoreactive for factor VIII, CD31, CD34, and vimentin. A diagnosis of epithelioid hemangioendothelioma was made and the patient underwent subtotal resection of the metatarsal bone with reconstruction of the fibula, and a wide resection of the tibial lesion. No recurrences or metastasis were observed during a four-year follow-up.
authors.affiliation: Department of Pathology (Patoloji Kliniği), Sişli Etfal Training and Research Hospital, Istanbul, Turkey. ykabukcuoglu@yahoo.com
authors.forename: Fevziye
authors.initials: F
authors.lastname: Kabukçuoğlu
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Kabukçuoğlu
authors.forename: Ayten
authors.initials: A
authors.lastname: Livaoğlu
authors.forename: Ayşim
authors.initials: A
authors.lastname: Ozağari
authors.forename: Raffi
authors.initials: R
authors.lastname: Armağan
authors.forename: Unal
authors.initials: U
authors.lastname: Kuzgun
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005360:Fibula / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008682:Metatarsal Bones / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014947:Wounds and Injuries