title: Bioorthogonal noncovalent chemistry: Fluorous phases in chemical biology.
abstract: Chemical entities designed to noncovalently interact with predetermined partners have fashioned a new paradigm in chemical biology. Fluorocarbons are extremely promising as supramolecular synthons toward these objectives. Bioorthogonal noncovalent interactions provide a way to modulate self-assembled systems in environments where such control has hitherto not been possible. Fluorocarbons have now found applications in self-assembly as well as proteomics, biomolecule purification and in the creation of microarray platforms. Other self-assembly motifs with similar attributes might be exploited using the same general approach.
authors.affiliation: Department of Chemistry, Tufts University, Medford, MA 02155, USA.
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Yoder
authors.forename: Deniz
authors.initials: D
authors.lastname: Yüksel
authors.forename: Laila
authors.initials: L
authors.lastname: Dafik
authors.forename: Krishna
authors.initials: K
authors.lastname: Kumar
mesh_terms: D002448:Cell Adhesion; D005466:Fluorocarbons / Q000737:chemistry*; D040901:Proteomics
chemical_list: D005466:Fluorocarbons