title: Meningococcal meningitis in two patients with primary antibody deficiency treated with replacement intravenous immunoglobulin.
abstract: The current treatment of primary antibody deficiency (PAD) is the early recognition of the condition and replacement immunoglobulin combined with prompt treatment of infections and complications. The route of administration (intravenous or subcutaneous), dose and frequency of administration of immunoglobulin still vary between centres and countries. Most infections in patients with PAD are reduced but not entirely prevented by replacement immunoglobulin, with sinopulmonary infections accounting for the bulk of the remainder. Although there have been reports of meningitis in patients with PAD before replacement treatment, we describe the first two cases of bacterial meningitis (group B Neisseria meningitidis) on adequate immunoglobulin replacement and discuss the involvement of potential cofactors.
authors.affiliation: Department of Clinical Immunology, Royal Free Hospital, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Lear
authors.forename: E
authors.initials: E
authors.lastname: Eren
authors.forename: J
authors.initials: J
authors.lastname: Findlow
authors.forename: R
authors.initials: R
authors.lastname: Borrow
authors.forename: D
authors.initials: D
authors.lastname: Webster
authors.forename: S
authors.initials: S
authors.lastname: Jolles
mesh_terms: D000328:Adult; D001770:Blood Bactericidal Activity; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008297:Male; D008585:Meningitis, Meningococcal / Q000150:complications / Q000628:therapy*; D009894:Opportunistic Infections / Q000150:complications / Q000628:therapy*
chemical_list: D016756:Immunoglobulins, Intravenous