title: Pharmacokinetic modelling of [2-13C]uracil metabolism in normal and DPD-deficient dogs.
abstract: A physiologically based pharmacokinetic (PBPK) model to simulate the plasma concentration and 13CO2 exhalation after [2-13C]uracil administration to DPD-suppressed dogs was developed. Simulation using this PBPK model should be useful in clinical situations where DPD-deficient patients at risk are to be detected with [2-13C]uracil as an in vivo probe.
authors.affiliation: Research Section, Diagnostics Division, Otsuka Pharmaceutical Co Ltd, Japan. inadam@otsuka.jp
authors.forename: M
authors.initials: M
authors.lastname: Inada
authors.forename: Y
authors.initials: Y
authors.lastname: Hirao
authors.forename: T
authors.initials: T
authors.lastname: Koga
authors.forename: M
authors.initials: M
authors.lastname: Itose
authors.forename: J
authors.initials: J
authors.lastname: Kunizaki
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Sato
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001944:Breath Tests; D002245:Carbon Dioxide / Q000737:chemistry; D002247:Carbon Isotopes / Q000378:metabolism*; D003198:Computer Simulation; D054067:Dihydropyrimidine Dehydrogenase Deficiency; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000096:biosynthesis* / Q000737:chemistry; D004285:Dogs; D007700:Kinetics; D008954:Models, Biological; D008956:Models, Chemical; D008962:Models, Theoretical; D013997:Time Factors; D014498:Uracil / Q000097:blood* / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D002247:Carbon Isotopes; D002245:Carbon Dioxide; D014498:Uracil; D042943:Dihydrouracil Dehydrogenase (NADP)