title: Isobologram analysis of triple therapies.
abstract: New concepts in radiation oncology are based on the concept that combinations of irradiation and molecular targeted drugs can yield synergistic or at least additive effects. Up to now the combination of two treatment modalities has been tested in almost all cases. Similar to conventional anti-cancer agents, the efficacy of targeted approaches is also subject to predefined resistance mechanisms. Therefore, it seems reasonable to speculate that a combination of more than two agents will ultimately increase the therapeutic gain. No tools for a bio-mathematical evaluation of a given degree of interaction for more than two anti-neoplastic agents are currently available. The present work introduces a new method for an evaluation of triple therapies and provides some graphical examples in order to visualize the results.
authors.affiliation: CCC Tübingen, Department of Radiation Oncology, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany. maxi@niyazi.de
authors.forename: Maximilian
authors.initials: M
authors.lastname: Niyazi
authors.forename: Claus
authors.initials: C
authors.lastname: Belka
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods*; D003627:Data Interpretation, Statistical; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D018787:Radiation Oncology / Q000379:methods / Q000639:trends*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents