Suburban leptospirosis: atypical lymphocytosis and gamma-delta T cell response.
Leptospirosis is a zoonotic disease associated with a changing global epidemiology. Recently, an increased incidence of canine leptospirosis in the northeastern United States and Canada has been associated with increasing rates of infection among reservoir hosts, such as skunks, raccoons, and squirrels, that are common in suburban settings. We describe a case of leptospirosis that provides new insight into the epidemiology, diagnosis, and pathogenesis of this disease acquired in the suburban setting. Atypical lymphocytosis corresponded to an expansion of gamma-delta T cells in peripheral blood.
Barry
Michele
M
Department of Medicine, Yale University School of Medicine, New Haven, CT, USA. michele.barry@yale.edu
Wisnewski
Adam V
AV
Matthias
Michael A
MA
Inouye
Sharon K
SK
Vinetz
Joseph M
JM
D000818:Animals; D002170:Canada / Q000453:epidemiology; D004285:Dogs; D007922:Leptospirosis / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D008218:Lymphocytosis / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D012889:Mephitidae; D009511:New England / Q000453:epidemiology; D011821:Raccoons; D013601:T-Lymphocytes / Q000276:immunology*