New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum.
Two new lanostanoids, 7-oxo-ganoderic acid Z (1) and 15-hydroxy-ganoderic acid S (2), were isolated from a lipophilic extract of the fruiting body of Ganoderma lucidum. The structures of both compounds were established by interpretation of their spectroscopic data. Compounds 1 and 2 both exhibited inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase.
Li
Canjun
C
Pharmanex Shanghai R&D, Building 11, Bi Po Rd, Shanghai 201203, China.
Li
Yiming
Y
Sun
Hao H
HH
D000363:Agaricales / Q000378:metabolism*; D006538:Heptanoic Acids / Q000737:chemistry* / Q000378:metabolism*; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000378:metabolism*
C515758:15-hydroxy-ganoderic acid S; C515759:7-oxo-ganoderic acid Z; D006538:Heptanoic Acids; D014315:Triterpenes; D007810:Lanosterol