title: [Effect of acupoint injection by Astragalus injection on local SIgA and pathomorphology changes in rats with chronic pelvic inflammatory disease].
abstract: OBJECTIVE
  To observe the effect of acupoint injection by astragalus injection on local SIgA and pathomorphologial changes in rats with chronic pelvic inflammatory disease (CPID).
  
  
  METHODS
  50 female Wistar rats were randomly devided into 6 groups, in which CPID model was made except the normal group and sham operation group. The astragalus injection group and the 0.9% NaCl injection group were treated by acupoint injection in Guanyuan (RN4) and Zusanli (ST36). The group was fed Qianjinpian solution into stomach. The histopathologic changes of rats' uterus of each group were observed and SIgA in vagina flushing was detected.
  
  
  RESULTS
  The model group showed inflammatory changes, and astragalus injection group and Qianjinpian group showed little histopathologic changes. The levels of SIgA in astragalus injection group were significantly higher than those in other groups, but that in the model group was the lowest.
  
  
  CONCLUSIONS
  The deficiency of local SIgA lead to repeatedly attack of CPID. The treatment of acupoint injection by astragalus injection can improve the excretion of SIgA, reinforce the local immunity, and prevent the repeatedly attack.
authors.affiliation: Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Xue-Fen
authors.initials: XF
authors.lastname: Cai
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Chen
authors.forename: Zhang-Lian
authors.initials: ZL
authors.lastname: Wang
authors.forename: Ying-Er
authors.initials: YE
authors.lastname: Gu
mesh_terms: D015669:Acupuncture Points; D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007071:Immunoglobulin A, Secretory / Q000097:blood*; D007267:Injections; D000292:Pelvic Inflammatory Disease / Q000097:blood / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000473:pathology*
chemical_list: D004365:Drugs, Chinese Herbal; D007071:Immunoglobulin A, Secretory