Yeast and filamentous fungi as model organisms in microbody research.
Yeast and filamentous fungi are important model organisms in microbody research. The value of these organisms as models for higher eukaryotes is underscored by the observation that the principles of various aspects of microbody biology are strongly conserved from lower to higher eukaryotes. This has allowed to resolve various peroxisome-related functions, including peroxisome biogenesis disorders in man. This paper summarizes the major advances in microbody research using fungal systems and specifies specific properties and advantages/disadvantages of the major model organisms currently in use.
van der Klei
Ida J
IJ
Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, PO Box 14, 9750 AA Haren, The Netherlands. I.J.van.der.Klei@rug.nl
Veenhuis
Marten
M
D003904:Mitosporic Fungi / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D020675:Peroxisomes / Q000502:physiology*; D015003:Yeasts / Q000235:genetics / Q000502:physiology*