title: Synthesis and application of quinazoline-oxazoline-containing (quinazox) ligands.
abstract: A practical synthesis of potentially tridentate P,N,N-ligands containing two stereogenic elements incorporated into the axially chiral Quinazolinap and centrally chiral 2-oxazoline subunits is reported. The application of these novel hybrid ligands in Pd(0)-catalyzed asymmetric allylic alkylation revealed the matched and mismatched diastereomer, dominant stereogenic element, as well as the effect of the oxazoline R substituent on the level of enantioselectivity (ee's up to 81%). [structure: see text]
authors.affiliation: Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Fekner
authors.forename: Helge
authors.initials: H
authors.lastname: Müller-Bunz
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Guiry