title: The oriented development of antituberculotics: salicylanilides.
abstract: On the basis of our previous results 22 salicylanilides were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. The Free-Wilson method was used to evaluate structure-antimycobacterial activity relationships. 4-Chloro-N-(4-propylphenyl)salicylamide and 5-chloro-N-(4-propylphenyl)salicylamide were selected for preclinical studies.
authors.affiliation: Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic. waisser@faf.cuni.cz
authors.forename: Karel
authors.initials: K
authors.lastname: Waisser
authors.forename: Josef
authors.initials: J
authors.lastname: Matyk
authors.forename: Hana
authors.initials: H
authors.lastname: Divisová
authors.forename: Petra
authors.initials: P
authors.lastname: Husáková
authors.forename: Jirí
authors.initials: J
authors.lastname: Kunes
authors.forename: Vera
authors.initials: V
authors.lastname: Klimesová
authors.forename: Jarmila
authors.initials: J
authors.lastname: Kaustová
authors.forename: Ute
authors.initials: U
authors.lastname: Möllmann
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Dahse
authors.forename: Milan
authors.initials: M
authors.lastname: Miko
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects; D019909:Mycobacterium kansasii / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D012458:Salicylanilides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D012458:Salicylanilides