title: Chiral base mediated transformation of cyclic 1,3-diketones.
abstract: Treatment of certain 1,3-diketones with a chiral lithium amide base results in the formation of a non-racemic lithium mono-enolate; these intermediates can be transformed directly into chiral hydroxyketone products by reduction with DIBAL-H in high yield and with selectivities of up to 99% ee.
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, UK NG7 2RD.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Butler
authors.forename: Thomas
authors.initials: T
authors.lastname: Schultz
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Simpkins