Chiral base mediated transformation of cyclic 1,3-diketones.
Treatment of certain 1,3-diketones with a chiral lithium amide base results in the formation of a non-racemic lithium mono-enolate; these intermediates can be transformed directly into chiral hydroxyketone products by reduction with DIBAL-H in high yield and with selectivities of up to 99% ee.
Butler
Benjamin
B
School of Chemistry, University of Nottingham, University Park, Nottingham, UK NG7 2RD.
Schultz
Thomas
T
Simpkins
Nigel S
NS