title: Visfatin concentration in Asian Indians is correlated with high density lipoprotein cholesterol and apolipoprotein A1.
abstract: BACKGROUND
  Visfatin is a recently described adipose tissue derived hormone whose role in humans remains largely unknown.
  
  
  OBJECTIVE
  To determine visfatin's relationship to lipoproteins and body composition parameters in Asian Indians and Caucasians.
  
  
  METHODS
  A cross-sectional study.
  
  
  METHODS
  Men and women living in Montreal, Canada between the ages of 20 and 60 years were recruited for participation in this study. Subjects were excluded if they had a history of CVD or were taking lipid lowering medication. Individuals identified themselves as Asian Indian or Caucasian.
  
  
  METHODS
  Anthropometric measurements were collected including weight, height, waist circumference, hip circumference and body fat percentage (BF%). Serum samples were analysed for total cholesterol, HDL-C, apoA1, apoB and visfatin.
  
  
  RESULTS
  There was no difference in visfatin levels between Indian and Caucasian men (64.50 +/- 3.98 ng/ml vs 73.01 +/- 6.45 ng/ml, ns, respectively) and Indian and Caucasian women (59.03 +/- 5.71 ng/ml vs 77.70 +/- 7.63 ng/ml, ns, respectively), despite large differences in BF%, apoB and the apoB/apoA1 ratio. Visfatin correlated positively to HDL-C and apoA1 in the Indian men (R = 0.42, P = 0.004 and R = 0.48, P = 0.003) and Indian women (R = 0.46, P = 0.05 and R = 0.59, P = 0.01).
  
  
  CONCLUSIONS
  Visfatin concentrations may be related to HDL metabolism in Asian Indian immigrants.
authors.affiliation: Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Canada.
authors.forename: Jessica
authors.initials: J
authors.lastname: Smith
authors.forename: Maha
authors.initials: M
authors.lastname: Al-Amri
authors.forename: Allan
authors.initials: A
authors.lastname: Sniderman
authors.forename: Katherine
authors.initials: K
authors.lastname: Cianflone
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D044466:Asian People; D001823:Body Composition; D015992:Body Mass Index; D002170:Canada; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase; D049629:Waist-Hip Ratio; D044465:White People
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human