The genetics of chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to disease pathogenesis and heterogeneity by causing variation in protease anti-protease systems, defence against oxidative stress and inflammation. The main methods of genomic research for complex disease traits are described, together with the genes implicated in COPD thus far, their roles in disease causation and the future for this area of investigation.
Wood
Alice M
AM
Department of Medical Sciences, University of Birmingham, Birmingham, UK. alice.wood@uhb.nhs.uk
Stockley
Robert A
RA
D016207:Cytokines / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D010447:Peptide Hydrolases / Q000235:genetics*; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
D016207:Cytokines; D010447:Peptide Hydrolases