title: The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma.
abstract: We have measured the concentrations of metabolites related to the turnover of NAD, which accumulate in the blood of children with renal failure. One is a novel nucleotide, identified as the N1-riboside triphosphate of 4-pyridone-3-carboxamide (4PYTP), also described as 4KNTP, which accumulates in the erythrocytes in parallel with renal failure.
authors.affiliation: Institute of Child Health, University College London, London, UK. e.carrey@ich.ucl.ac.uk
authors.forename: E A
authors.initials: EA
authors.lastname: Carrey
authors.forename: E
authors.initials: E
authors.lastname: Synesiou
authors.forename: H A
authors.initials: HA
authors.lastname: Simmonds
authors.forename: L D
authors.initials: LD
authors.lastname: Fairbanks
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008297:Male; D009243:NAD / Q000378:metabolism; D009536:Niacinamide / Q000031:analogs & derivatives / Q000378:metabolism; D009711:Nucleotides / Q000097:blood* / Q000737:chemistry; D051437:Renal Insufficiency / Q000097:blood*
chemical_list: C516364:4-pyridone-3-carboxamide N-1 riboside triphosphate; D009711:Nucleotides; D009243:NAD; D009536:Niacinamide; D000255:Adenosine Triphosphate; C005211:N'-methyl-2-pyridone-5-carboxamide