Yeast unravels epigenetic apoptosis control: deadly chat within a histone tail.
An important paper by David Allis and colleagues (Ahn et al., 2006 [this issue of Molecular Cell]) describes a specific deacetylation/phosphorylation crosstalk at the histone H2B tail required for apoptosis induction in yeast, thus giving first insights into the poorly understood epigenetic regulation of cell death.
Carmona-Gutierrez
Didac
D
Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.
Madeo
Frank
F
D000107:Acetylation; D017209:Apoptosis; D044127:Epigenesis, Genetic; D005656:Fungal Proteins / Q000737:chemistry; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D015003:Yeasts / Q000378:metabolism
D005656:Fungal Proteins; D006657:Histones