title: Is the PCOS diagnosis solved by ESHRE/ASRM 2003 consensus or could it include ultrasound examination of the ovarian stroma?
abstract: BACKGROUND
  The clinical heterogeneity of polycystic ovary syndrome (PCOS) is mirrored by the unceasing debate on the most appropriate diagnostic criteria.
  
  
  RESULTS
  To highlight differences and inconsistencies between NIH and ESHRE/ASRM criteria, we applied them to 375 patients with oligo/amenorrhoea and signs of hyperandrogenism. Among them, we identified 273 women with PCOS according to NIH, whereas up to 345 patients fulfilled ESHRE/ASRM criteria. The 72 patients, constituting the gap between the two classifications, exhibited a lower expression of clinical signs compared with the 273 patients matching both criteria. To the whole group, we then applied the ESHRE/ASRM criteria modified to include an easily reproducible ultrasound examination of the ovarian stroma (UCSC criteria). In this way, we identified 30 women who were healthy according to all criteria, 37 affected by PCOS according only to the ESHRE/ASRM Consensus, 35 affected according only to the UCSC and ESHRE/ASRM criteria and 273 who were considered to have PCOS by all criteria. These groups showed a progressively increasing expression of PCOS features.
  
  
  CONCLUSIONS
  In the grey area between NIH and ESHRE/ASRM classifications, UCSC criteria could identify a subgroup of women, missed by NIH criteria, with more pronounced stigmas than those identified by ESHRE/ASRM criteria alone, and who may profit more from a targeted therapy.
authors.affiliation: ISI, Istituto Scientifico Internazionale Paolo VI, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Belosi
authors.forename: L
authors.initials: L
authors.lastname: Selvaggi
authors.forename: R
authors.initials: R
authors.lastname: Apa
authors.forename: M
authors.initials: M
authors.lastname: Guido
authors.forename: D
authors.initials: D
authors.lastname: Romualdi
authors.forename: A M
authors.initials: AM
authors.lastname: Fulghesu
authors.forename: A
authors.initials: A
authors.lastname: Lanzone
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D016000:Cluster Analysis; D015331:Cohort Studies; D032921:Consensus; D003937:Diagnosis, Differential; D003944:Diagnostic Techniques, Obstetrical and Gynecological; D005260:Female; D006801:Humans; D009316:National Institutes of Health (U.S.); D010053:Ovary / Q000166:cytology / Q000473:pathology*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000378:metabolism; D017154:Stromal Cells; D014463:Ultrasonography; D014481:United States
chemical_list: D015415:Biomarkers