5-endo Heck-type cyclization of 2-(trifluoromethyl)allyl ketone oximes: Synthesis of 4-difluoromethylene-substituted 1-pyrrolines.
2-(Trifluoromethyl)allyl ketone O-pentafluorobenzoyloximes undergo a palladium-catalyzed 5-endo mode of alkene insertion via oxidative addition of the N-O bond, followed by beta-fluorine elimination to produce 4-difluoromethylene-1-pyrrolines.
Ichikawa
Junji
J
Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. junji@chem.s.u-tokyo.ac.jp
Nadano
Ryo
R
Ito
Naotaka
N