[Effect of Lorazepam on emotional status and quality of life of patients with ischemic heart disease].
OBJECTIVE
To investigate emotional status and quality of life of patients with ischemic heart disease (IHD) with various anxiety and effect of therapy with benzodiazepine anxiolytic lorazepam on these parameters.


METHODS
Hospital scale of anxiety and depression, Beck Depression Inventory, and Seattle Questionnaire were used for assessment of anxiety, depression, and quality of life, respectively, in 277 patients with IHD.


RESULTS
Patients with clinically evident level of depression had higher level of vegetative disturbances, worse quality of life and prognosis. Improvement of not only emotional state (lowering of anxiety and depression level) but also of quality of life occurred in patients with clinically pronounced level of depression at the background of treatment with lorazepam.


CONCLUSIONS
Lorazepam is effective and safe preparation for the treatment of anxiety disorders in patients with IHD. Lorazepam improves not only emotional status of these patients but their quality of life as well.
Ibatov
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AD
D000328:Adult; D000339:Affect / Q000187:drug effects*; D000368:Aged; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
D014151:Anti-Anxiety Agents; D008140:Lorazepam