Modelling microtubule patterns.
The cellular cytoskeleton is well studied in terms of its biological and physical properties, making it an attractive subject for systems approaches. Here, we describe the experimental and theoretical strategies used to study the collective behaviour of microtubules and motors. We illustrate how this led to the beginning of an understanding of dynamic cellular patterns that have precise functions.
Karsenti
Eric
E
European Molecular Systems Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. karsenti@embl.de
Nédélec
François
F
Surrey
Thomas
T
D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000465:Algorithms; D000818:Animals; D006801:Humans; D007700:Kinetics; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D008956:Models, Chemical; D011485:Protein Binding; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
D014404:Tubulin; D000255:Adenosine Triphosphate