The relationship between depression and serum ferritin level.
OBJECTIVE
This study looks at the association of depression and serum ferritin level.


METHODS
Case-control study.


METHODS
University hospital.


METHODS
Two hundred and five female medical students of Free University of Medical Sciences in Tehran were selected for the study (mean age; 24.5+/-1.6 years). Of these, 13 subjects were excluded and finally 192 subjects took part in the study.


METHODS
A questionnaire was filled in by each participant for the diagnosis of depression to be made. Based on the Beck score, the students were grouped as depressed and healthy (67 depressed students and 125 healthy controls). The participants were evaluated in terms of hemoglobin (Hgb) level, serum ferritin, ESR (erythrocyte sedimentation rate), CRP (C-reactive protein), folic acid, vitamin B12 and Hgb simultaneously.


RESULTS
The prevalence of depression in the study population was 34.7%. The mean ferritin level in students with depression was significantly lower than the healthy ones (P<0.001). By changing the status from normal ferritin level to low ferritin level, odds of depression was increased by 1.92 (P<0.05).


CONCLUSIONS
The study implies a possible association between depression and decreased ferritin level before the occurrence of anemia.


BACKGROUND
Free University of Medical Sciences.
Vahdat Shariatpanaahi
M
M
Department of Psychiatry, Free Islamic University of Medical Sciences, Tehran, Iran.
Vahdat Shariatpanaahi
Z
Z
Moshtaaghi
M
M
Shahbaazi
S H
SH
Abadi
A
A
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000453:epidemiology; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003863:Depression / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D005293:Ferritins / Q000097:blood*; D005492:Folic Acid / Q000097:blood; D006304:Health Status; D006454:Hemoglobins / Q000032:analysis; D006785:Hospitals, University; D006801:Humans; D007492:Iran / Q000453:epidemiology; D007501:Iron / Q000097:blood; D000090463:Iron Deficiencies; D016015:Logistic Models; D013337:Students, Medical; D011795:Surveys and Questionnaires; D014805:Vitamin B 12 / Q000097:blood
D006454:Hemoglobins; D002097:C-Reactive Protein; D005293:Ferritins; D005492:Folic Acid; D007501:Iron; D014805:Vitamin B 12