title: In vitro-clinical correlations for amphotericin B susceptibility in AIDS-associated cryptococcal meningitis.
abstract: Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.
authors.affiliation: Department of Medicine (Infectious Diseases), 2020 Zonal Ave., IRD Room 620, MC 9520, University of Southern California, Los Angeles, CA 90033, USA. rlarsen@usc.edu
authors.forename: R A
authors.initials: RA
authors.lastname: Larsen
authors.forename: M
authors.initials: M
authors.lastname: Bauer
authors.forename: A E
authors.initials: AE
authors.lastname: Brouwer
authors.forename: A
authors.initials: A
authors.lastname: Sanchez
authors.forename: A M
authors.initials: AM
authors.lastname: Thomas
authors.forename: A
authors.initials: A
authors.lastname: Rajanuwong
authors.forename: W
authors.initials: W
authors.lastname: Chierakul
authors.forename: S J
authors.initials: SJ
authors.lastname: Peacock
authors.forename: N
authors.initials: N
authors.lastname: Day
authors.forename: N J
authors.initials: NJ
authors.lastname: White
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: T S
authors.initials: TS
authors.lastname: Harrison
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*; D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D003455:Cryptococcus neoformans / Q000187:drug effects*; D006801:Humans; D016919:Meningitis, Cryptococcal / Q000188:drug therapy / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D012044:Regression Analysis
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B