title: Acoustic estimation of thermal distribution in the vicinity of femtosecond laser-induced optical breakdown.
abstract: Laser-induced optical breakdown (LIOB), or photo-disruption, can generate individual microbubbles in tissues for biomedical applications. We have previously developed a co-localized high-frequency ultrasound system to detect and characterize these laser-induced microbubbles. Because ultrasound speed varies with temperature, this system can also be used to directly estimate thermal effects in the vicinity of photodisruption. In this study, individual bubbles (sizes 60-100 microm) were created at the bottom of a water tank using a 793-nm, 100-fs Ti:Sapphire laser pulsed at 250 kHz. During and after breakdown, pulse-echoes from the tank bottom in the region surrounding a bubble were recorded with a single-element 85-MHz ultrasonic transducer, and temperature-dependent pulse-echo displacements were calculated using phase-sensitive correlation tracking. These displacements were then fit to a finite-element heat transfer model to estimate the effective thermal distribution. Estimates were calculated for laser exposure times ranging from 6.25 to 312.5 ms (1600 to 78 000 laser pulses), at 1.5 and 4 J/cm2 fluences. Results suggest a minimal temperature increase (<1 degrees C) within 100 microm of a bubble created with <1600 laser pulses at 1.5 J/cm2 fluence. This implies that LIOB can be controlled to be thermally noninvasive in the bubble vicinity.
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2099, USA. marwajoy@umich.edu
authors.forename: Marwa J
authors.initials: MJ
authors.lastname: Zohdy
authors.forename: Christine
authors.initials: C
authors.lastname: Tse
authors.forename: Jing Yong
authors.initials: JY
authors.lastname: Ye
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Donnell
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D003198:Computer Simulation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D053685:Laser Therapy / Q000295:instrumentation* / Q000379:methods*; D008954:Models, Biological; D013817:Thermography / Q000295:instrumentation* / Q000379:methods