Brain natriuretic peptide as marker of myocardial iron load in beta-thalassemia.
Cardiomyopathy due to iron overload represents a frequent life-limiting complication in patients with beta-thalassemia major. We have conducted a study which proved that brain natriuretic peptide plasma levels have high sensitivity and negative predictive value in detecting cardiac hemosiderosis.
Nikolidakis
Savvas
S
Flessa
Constantina
C
Nikolaou
Nikolaos
N
Gotsis
Efstathios D
ED
Koutouzis
Michael
M
Polyhronaki
Eleni
E
Vrettou
Eleni
E
Kyriakides
Zenon S
ZS
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001803:Blood Transfusion / Q000379:methods; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D006486:Hemosiderosis / Q000175:diagnosis; D006801:Humans; D019190:Iron Overload / Q000175:diagnosis*; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood* / Q000378:metabolism; D011237:Predictive Value of Tests; D011336:Probability; D011379:Prognosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017086:beta-Thalassemia / Q000150:complications* / Q000175:diagnosis / Q000628:therapy
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain