Desorption electrospray ionization using an Orbitrap mass spectrometer: Exact mass measurements on drugs and peptides.
Desorption electrospray ionization (DESI) is implemented on an Orbitrap mass spectrometer. The ion source is described and applications which utilize the high-resolution capabilities of the Orbitrap are emphasized, including the characterization of peptides and active ingredients in pharmaceutical tablets. Measurements are made in less than 1 s at a resolution of 60,000. The implications of the data for the mechanisms of DESI are discussed.
Hu
Qizhi
Q
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Talaty
Nari
N
Noll
Robert J
RJ
Cooks
R Graham
RG
D001920:Bradykinin / Q000737:chemistry; D017336:Loratadine / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation* / Q000379:methods*; D013607:Tablets
D010455:Peptides; D004364:Pharmaceutical Preparations; D013607:Tablets; D017336:Loratadine; D001920:Bradykinin