title: Does the method of treatment affect the outcome in soft-tissue sarcomas of the adductor compartment?
abstract: We have investigated the significance of the method of treatment on the oncological and functional outcomes and on the complications in 184 patients with soft-tissue sarcomas of the adductor compartment managed at three international centres. The overall survival at five years was 65% and was related to the grade at diagnosis and the size of the tumour. There was no difference in overall survival between the three centres. There was, however, a significant difference in local control with a rate of 28% in Centre 1 compared with 10% in Centre 2 and 5% in Centre 3. The overall mean functional score using the Toronto Extremity Salvage Score in 70 patients was 77% but was significantly worse in patients with wound complications or high-grade tumours. The scores were not affected by the timing of radiotherapy or the use of muscle flaps. This large series of soft-tissue sarcomas of the adductor compartment has shown that factors influencing survival do not vary across the international boundaries studied, but that methods of treatment affect complications, local recurrence and function.
authors.affiliation: Royal Orthopaedic Hospital Oncology Service, Birmingham, England.
authors.forename: A
authors.initials: A
authors.lastname: Pradhan
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheung
authors.forename: R J
authors.initials: RJ
authors.lastname: Grimer
authors.forename: A
authors.initials: A
authors.lastname: Abudu
authors.forename: D
authors.initials: D
authors.lastname: Peake
authors.forename: P C
authors.initials: PC
authors.lastname: Ferguson
authors.forename: A M
authors.initials: AM
authors.lastname: Griffin
authors.forename: J S
authors.initials: JS
authors.lastname: Wunder
authors.forename: B
authors.initials: B
authors.lastname: O'Sullivan
authors.forename: R
authors.initials: R
authors.lastname: Hugate
authors.forename: F H
authors.initials: FH
authors.lastname: Sim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D016019:Survival Analysis; D013848:Thigh / Q000601:surgery; D016896:Treatment Outcome