title: REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease.
abstract: OBJECTIVE
  To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects.
  
  
  METHODS
  Overnight polysomnography.
  
  
  METHODS
  Sleep laboratory.
  
  
  METHODS
  Fifteen patients with probable Alzheimer disease (mean age +/-SD, 70.2+/-5.6) and 15 age-matched healthy control subjects (mean age +/- SD, 67.9 +/-5.4).
  
  
  METHODS
  N/A.
  
  
  RESULTS
  Four patients with Alzheimer disease presented REM sleep with-out atonia. One of these patients had all the polysomnographic features of RBD, including behavioral manifestations during REM sleep.
  
  
  CONCLUSIONS
  RBD is rare, but REM sleep without atonia is relatively fre-quent in patients with probable Alzheimer disease, a tauopathy.
authors.affiliation: Centre d'étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur de Montréal, Qudbec, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Gagnon
authors.forename: Dominique
authors.initials: D
authors.lastname: Petit
authors.forename: Maria Livia
authors.initials: ML
authors.lastname: Fantini
authors.forename: Sylvie
authors.initials: S
authors.lastname: Rompré
authors.forename: Serge
authors.initials: S
authors.lastname: Gauthier
authors.forename: Michel
authors.initials: M
authors.lastname: Panisset
authors.forename: Alain
authors.initials: A
authors.lastname: Robillard
authors.forename: Jacques
authors.initials: J
authors.lastname: Montplaisir
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009123:Muscle Hypotonia / Q000175:diagnosis / Q000453:epidemiology*; D010507:Periodicity; D017286:Polysomnography; D015995:Prevalence; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology*; D051843:Synucleins / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D051843:Synucleins; D016875:tau Proteins