Antioxidative phenolics from the fresh leaves of Ternstroemia japonica.
Six new phenylethanoid glucosides, ternstrosides A-F (1-6), a new kaempferol derivative (7), and eight known compounds were isolated from the fresh leaves of Ternstroemia japonica. The structures were elucidated by 1D and 2D NMR spectroscopic analyses. Compounds 1-7 showed potent antioxidative activity in three different tests, with IC50 values in the range 3.26-6.50 microM in the hydroxyl radical (*OH) inhibitory activity test, 33.29-82.21 microM in the total ROS (reactive oxygen species) inhibitory activity test, and 1.14-13.53 microM in the peroxynitrite (ONOO-) scavenging activity test.
Jo
Youngmi
Y
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Kim
Minkyung
M
Shin
Myung Hee
MH
Chung
Hae Young
HY
Jung
Jee H
JH
Im
Kwang Sik
KS
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029791:Ericaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007668:Kidney / Q000166:cytology; D007723:Korea; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D030421:Peroxynitrous Acid / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000494:pharmacology
D000975:Antioxidants; D016166:Free Radical Scavengers; D005960:Glucosides; D010636:Phenols; D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid; D017665:Hydroxyl Radical