title: Effect of neonatal sepsis on the development of allergies and asthma in later childhood.
abstract: BACKGROUND
  Exposure to large amounts of endotoxins and other bacterial products in early childhood may protect against the development of allergic diseases later in childhood. The aim of this study was to investigate the effects of neonatal sepsis on subsequent development of asthma, allergic rhinitis, and atopic dermatitis in children.
  
  
  METHODS
  We recruited 85 children (mean age 48.67 +/- 12.88 months) who had been hospitalized for sepsis in their neonatal period and their siblings (n = 85) as controls (mean age 61.81 +/- 21.34 months) to investigate the prevalences of asthma, atopic dermatitis and allergic rhinitis. After asking the questions in the International Study of Asthma and Allergies in Children (ISAAC) questionnaires to the parents, total IgE levels in sera were measured and skin prick tests were performed.
  
  
  RESULTS
  Children with neonatal sepsis had lower total IgE levels and less sensitivity to Dermatophagoides pteronyssinus than controls (25.9 vs. 9.4%, p = 0.003). In addition, wheeze ever, wheeze in the last 12 months, physician-diagnosed asthma, and use of asthma drugs were less common in these subjects. Prevalences of allergic rhinitis and atopic dermatitis were equal in both groups.
  
  
  CONCLUSIONS
  Exposure to severe infections such as sepsis in the neonatal period may decrease sensitization to environmental allergens and prevalence of asthma in later childhood.
authors.affiliation: Sisli Etfal Education and Research Hospital, Istanbul, Turkey. feyzulkaya@mynet.com
authors.forename: Feyzullah
authors.initials: F
authors.lastname: Cetinkaya
authors.forename: Hasan Sinan
authors.initials: HS
authors.lastname: Uslu
authors.forename: Asiye
authors.initials: A
authors.lastname: Nuhoğlu
mesh_terms: D039741:Antigens, Dermatophagoides / Q000276:immunology; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D007073:Immunoglobulin E / Q000097:blood; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D018805:Sepsis / Q000276:immunology*; D012882:Skin Tests
chemical_list: D039741:Antigens, Dermatophagoides; D007073:Immunoglobulin E