In-vitro biological evaluation of some ONS and NS donor Schiff's bases and their metal complexes.
Complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with the Schiff bases salicylidene-o-aminothiophenol (H2L) and thiophene-o-carboxaldeneaniline (SB) have been synthesized and characterized by elemental analyses, magnetic measurements, thermogravimetric analyses as well as infrared spectra and reflectance spectra. The nature of the bonding has been discussed on the basis of IR spectral data. Magnetic susceptibility measurements and electronic spectral data suggest a six-coordinated octahedral structure for these complexes. The complexes of Mn(II), Co(II), Ni(II), Cu(II) are paramagnetic, while Zn(II) and Cd(II) are diamagnetic in nature. The complexes were tested for their antimicrobial activities against Salmonella typhi, Escherichia coli and Serratia marcescens using the "Disc Diffusion Method". The results are compared with the standard drug (tetracycline) and show moderate activity.
Panchal
Pragnesh K
PK
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat 388120, India.
Pansuriya
Pramod B
PB
Patel
M N
MN
D000890:Anti-Infective Agents; D004353:Drug Evaluation, Preclinical; D008826:Microbial Sensitivity Tests / Q000379:methods*; D008956:Models, Chemical; D009584:Nitrogen / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D011485:Protein Binding; D011994:Recombinant Proteins / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013455:Sulfur / Q000737:chemistry*; D013752:Tetracycline / Q000737:chemistry*; D013818:Thermogravimetry / Q000379:methods; D028561:Transition Elements
D000890:Anti-Infective Agents; D011994:Recombinant Proteins; D012545:Schiff Bases; D028561:Transition Elements; D013455:Sulfur; D013752:Tetracycline; D009584:Nitrogen; D010100:Oxygen