Transcription factors regulating beta-cell function.
Type 2 diabetes is primarily associated with insulin resistance and beta-cell dysfunction. Maintenance of functional mature beta-cells is imperative for ensuring glucose homeostasis. This can be achieved by optimal expression of key transcription factors that are required for normal pancreatic development and maintaining beta-cell function. Defining the regulation of transcription factors as well as their regulation of important beta-cell genes like insulin will provide further insight into elucidating the mechanisms leading to beta-cell dysfunction.
Cerf
Marlon E
ME
Diabetes Discovery Platform, South African Medical Research Council, PO Box 19070, Tygerberg, 7505, South Africa. marlon.cerf@mrc.ac.za
D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology; D005136:Eye Proteins / Q000502:physiology; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000502:physiology; D051542:Hepatocyte Nuclear Factor 3-beta / Q000502:physiology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology*; D050977:Maf Transcription Factors / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000502:physiology; D010179:Pancreas / Q000196:embryology; D012097:Repressor Proteins / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*
D051792:Basic Helix-Loop-Helix Proteins; D005136:Eye Proteins; D051538:Hepatocyte Nuclear Factor 1-alpha; D051542:Hepatocyte Nuclear Factor 3-beta; D018398:Homeodomain Proteins; D050977:Maf Transcription Factors; D009419:Nerve Tissue Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C491709:PAX4 protein, human; C000605730:PAX6 protein, human; C084010:pancreatic and duodenal homeobox 1 protein; C093564:Neurogenic differentiation factor 1