title: Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis.
abstract: The aim of this study was to evaluate the prevalence of vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with various demographic and renal osteodystrophy markers.
  
  
  METHODS
  This cross-sectional, multicenter study was carried out in 273 PD patients with a mean age of 61.7 +/- 10.9 years and mean duration of PD 3.3 +/- 2.2 years. It included 123 female and 150 male patients from 20 centers in Greece and Turkey, countries that are on the same latitude, namely, 36-42 degrees north. We measured 25(OH)D3 and 1.25(OH)2D3 levels and some other clinical and laboratory indices of bone mineral metabolism.
  
  
  RESULTS
  Of these 273 patients 92% (251 patients) had vitamin D deficiency i.e. serum 25(OH)D3 levels less than 15 ng/ml, 119 (43.6%) had severe vitamin D deficiency i.e., serum 25(OH)D3 levels, less than 5 ng/ml, 132 (48.4%) had moderate vitamin D deficiency i.e., serum 25(OH)D3 levels, 5-15 ng/ml, 12 (4.4%) vitamin D insufficiency i.e., serum 25(OH)D3 levels 15 - 30 ng/ml and only 10 (3.6%) had adequate vitamin D stores. We found no correlation between 25(OH)D3 levels and PTH, serum albumin, bone alkaline phosphatase, P, and Ca x P. In multiple regression analyses, the independent predictors of 25(OH)D3 were age, presence of diabetes (DM-CRF), levels of serum calcium and serum 1.25(OH)2D3.
  
  
  CONCLUSIONS
  We found a high prevalence (92%) of vitamin D deficiency in these 273 PD patients, nearly one half of whom had severe vitamin D deficiency. Vitamin D deficiency is more common in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that these patients should be considered for vitamin D supplementation.
authors.affiliation: Inonu University Medical School, Department of Medicine, Division of Nephrology, Malatya, Turkey. hulyataskapan@yahoo.com
authors.forename: H
authors.initials: H
authors.lastname: Taskapan
authors.forename: F F
authors.initials: FF
authors.lastname: Ersoy
authors.forename: P S
authors.initials: PS
authors.lastname: Passadakis
authors.forename: P
authors.initials: P
authors.lastname: Tam
authors.forename: D E
authors.initials: DE
authors.lastname: Memmos
authors.forename: K P
authors.initials: KP
authors.lastname: Katopodis
authors.forename: C
authors.initials: C
authors.lastname: Ozener
authors.forename: F
authors.initials: F
authors.lastname: Akcicek
authors.forename: T
authors.initials: T
authors.lastname: Camsari
authors.forename: K
authors.initials: K
authors.lastname: Ates
authors.forename: R
authors.initials: R
authors.lastname: Ataman
authors.forename: J G
authors.initials: JG
authors.lastname: Vlachojannis
authors.forename: N A
authors.initials: NA
authors.lastname: Dombros
authors.forename: C
authors.initials: C
authors.lastname: Utas
authors.forename: T
authors.initials: T
authors.lastname: Akpolat
authors.forename: S
authors.initials: S
authors.lastname: Bozfakioglu
authors.forename: G
authors.initials: G
authors.lastname: Wu
authors.forename: I
authors.initials: I
authors.lastname: Karayaylali
authors.forename: T
authors.initials: T
authors.lastname: Arinsoy
authors.forename: C P
authors.initials: CP
authors.lastname: Stathakis
authors.forename: M
authors.initials: M
authors.lastname: Yavuz
authors.forename: D J
authors.initials: DJ
authors.lastname: Tsakiris
authors.forename: A D
authors.initials: AD
authors.lastname: Dimitriades
authors.forename: M E
authors.initials: ME
authors.lastname: Yilmaz
authors.forename: M
authors.initials: M
authors.lastname: Gültekin
authors.forename: D G
authors.initials: DG
authors.lastname: Oreopoulos
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003928:Diabetic Nephropathies / Q000628:therapy; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000209:etiology*
chemical_list: D014807:Vitamin D