title: Quantitative trait loci modulate vertebral morphology and mechanical properties in a population of 18-month-old genetically heterogeneous mice.
abstract: The aim of this study was to examine effects of polymorphic genes on vertebral bone morphology and mechanical properties. Genotypes from 525 18-month-old female mice were compared to geometric traits obtained from micro-computed tomography and mechanical properties from compression testing. Genetic markers were associated with traits on at least 13 different chromosomes, demonstrating the complexity of genetic control over vertebral form, function and aging.
authors.affiliation: Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109-2200, USA.
authors.forename: Grant M
authors.initials: GM
authors.lastname: Reeves
authors.forename: Barbara R
authors.initials: BR
authors.lastname: McCreadie
authors.forename: Shu
authors.initials: S
authors.lastname: Chen
authors.forename: Andrzej T
authors.initials: AT
authors.lastname: Galecki
authors.forename: David T
authors.initials: DT
authors.lastname: Burke
authors.forename: Richard A
authors.initials: RA
authors.lastname: Miller
authors.forename: Steven A
authors.initials: SA
authors.lastname: Goldstein
mesh_terms: D000375:Aging; D000818:Animals; D001696:Biomechanical Phenomena; D033481:Chromosomes, Mammalian / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D040641:Quantitative Trait Loci; D013131:Spine / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D005819:Genetic Markers