title: Effects of taurine, carnosine, and casomorphine on functional activity of rat peritoneal mast cells.
abstract: We studied the effects of taurine, carnosine, and casomorphine on histamine release from rat peritoneal mast cells induced by compound 48/80 and ionophore A23187. Differences were revealed in the effect of the test preparations. Taurine inhibited histamine release induced by ionophore A23187, but not by compound 48/80. Carnosine abolished the stimulatory effect of compound 48/80 on histamine release, but did not modulate the effect of ionophore A23187. Casomorphine inhibited histamine release induced by ionophore A23187, but potentiated the effect of compound 48/80. The mechanisms for these effects are discussed.
authors.affiliation: Laboratory of Radiation Biophysics, Department of Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University. amedea@biophys.msu.ru
authors.forename: M Ya
authors.initials: MY
authors.lastname: Akhalaya
authors.forename: A A
authors.initials: AA
authors.lastname: Baizhumanov
authors.forename: E E
authors.initials: EE
authors.lastname: Graevskaya
mesh_terms: D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002336:Carnosine / Q000494:pharmacology*; D004723:Endorphins / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D010529:Peritoneal Cavity / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D004723:Endorphins; D010446:Peptide Fragments; D013654:Taurine; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; C041128:beta-casomorphin 7; D002336:Carnosine