title: Malon dialdehyde, nitrite and adrenomedullin levels in patients with premenstrual syndrome.
abstract: OBJECTIVE
  To assess the levels of malon dialdehyde (MDA); a lipid peroxide product, total nitrite; a stabile product of nitric oxide (NO), and adrenomedullin (AM), to determine whether their levels are altered in premenstrual syndrome (PMS) and to search for their possible pathophysiological role in this peculiar syndrome.
  
  
  METHODS
  Twenty-one patients aged between 28 and 37 years, who had regular menses for at least six previous cycles, and were in general good health condition, were taken into the study. Blood samples were obtained from each patient at the 3rd and 21st day of their menstrual cycles. AM, nitrite, MDA and estradiol levels have been assessed in these samples for each patient.
  
  
  RESULTS
  No statistically significant difference in terms of age, parity and body mass index was detected among groups (P > 0.05). Nitric oxide levels were higher on the 3rd day, compared to 21st day in the study group, and this difference was statistically significant (P < 0.05). In the study group, 21st day AM levels were significantly higher when compared to the control group (P < 0.05).
  
  
  CONCLUSIONS
  Even though various stress symptoms are present in PMS, there is no change in the levels of MDA, an oxidative distress indicator but AM and NO may have a pathophysiological role on this enigmatic disease.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Gaziantep University, 27310 Sahinbey, Gaziantep, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Balat
authors.forename: Ebru
authors.initials: E
authors.lastname: Dikensoy
authors.forename: Mete Gurol
authors.initials: MG
authors.lastname: Ugur
authors.forename: Rusen
authors.initials: R
authors.lastname: Atmaca
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cekmen
authors.forename: Muhuttin
authors.initials: M
authors.lastname: Yurekli
mesh_terms: D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D008597:Menstrual Cycle; D009569:Nitric Oxide / Q000097:blood; D009573:Nitrites / Q000097:blood*; D011293:Premenstrual Syndrome / Q000097:blood*
chemical_list: D009573:Nitrites; D053607:Adrenomedullin; D009569:Nitric Oxide; D008315:Malondialdehyde