title: Spoligotype signatures in the Mycobacterium tuberculosis complex.
abstract: Evolution of the direct repeat region in Mycobacterium tuberculosis has created unique spoligotype signatures specifically associated with IS6110-defined strain families. Spoligotyping signatures may enable the analysis of the strain population structure in different settings and will enable the rapid identification of strain families that acquire drug resistance or escape protective immunity in drug and vaccine trials.
authors.affiliation: DST/NRF Centre of Excellence in Biomedical TB Research, Department of Medical Biochemistry, Stellenbosch University, Tygerberg, South Africa 7505.
authors.forename: E M
authors.initials: EM
authors.lastname: Streicher
authors.forename: T C
authors.initials: TC
authors.lastname: Victor
authors.forename: G
authors.initials: G
authors.lastname: van der Spuy
authors.forename: C
authors.initials: C
authors.lastname: Sola
authors.forename: N
authors.initials: N
authors.lastname: Rastogi
authors.forename: P D
authors.initials: PD
authors.lastname: van Helden
authors.forename: R M
authors.initials: RM
authors.lastname: Warren
mesh_terms: D015373:Bacterial Typing Techniques; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D005838:Genotype; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics*; D009841:Oligonucleotides / Q000032:analysis*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics
chemical_list: D004251:DNA Transposable Elements; D009841:Oligonucleotides