Expedient five-step synthesis of SIB-1508Y from natural nicotine.
Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.
Wagner
Florence F
FF
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA.
Comins
Daniel L
DL
D000978:Antiparkinson Agents / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009538:Nicotine / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000978:Antiparkinson Agents; D011725:Pyridines; D011759:Pyrrolidines; D009538:Nicotine; C100989:altinicline maleate