title: Bioactive compounds from the seed fungus Menisporopsis theobromae BCC 3975.
abstract: Eight new compounds (2-9), together with a known dithiodiketopiperazine (1), were isolated from the seed fungus Menisporopsis theobromae BCC 3975. The structures of these substances were elucidated by analyses of spectroscopic data. Compounds 1 and 4 exhibited moderate cytotoxicity against BC-1 cell lines with IC50 values of 29.2 and 57.4 microM, respectively. Cytotoxicity of 1, 2, 4, and 9 against the NCI-H187 cell line showed respective IC50 values of 22.9, 20.3, 1.8, and 56.6 microM. Compounds 2 and 4 exhibited antimalarial activity with IC50 values of 2.95 and 28.8 microM, respectively. Substances 1, 4, 7, 8, and 9 possessed weak antimycobacterial activity (MIC 154.8-952.3 microM), while compounds 2 and 3 showed potent antimycobacterial activity with respective MIC values of 1.24 and 7.14 microM.
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. maneekarn@swu.ac.th
authors.forename: Maneekarn
authors.initials: M
authors.lastname: Chinworrungsee
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
authors.forename: Janya
authors.initials: J
authors.lastname: Saenboonrueng
authors.forename: Palangpon
authors.initials: P
authors.lastname: Kongsaeree
authors.forename: Yodhathai
authors.initials: Y
authors.lastname: Thebtaranonth
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D013785:Thailand
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D010879:Piperazines