title: Dysbiosis and pouchitis.
abstract: METHODS
  The exact aetiology of pouchitis is unknown, but an association with dysbiosis has been suggested. This is a retrospective review of 17 studies published between 1985 and 2005, identified by a search of the Medline, Pubmed and Embase databases.
  
  
  RESULTS
  The methodology of the studies varied widely. Many were performed at a time when the distinction between a healthy and an inflamed pouch was vague; misclassification of patients makes the analysis of data difficult and conclusions uncertain.
  
  
  CONCLUSIONS
  The evidence that dysbiosis is a cause of pouchitis is poor. Nevertheless, available data allow the construction of an algorithm to aid management and suggest a structured approach for future research.
authors.affiliation: Department of Colorectal Surgery, Leeds General Infirmary, Leeds, UK. mklim@Surgicalresearch.Fsnet.co.uk
authors.forename: M
authors.initials: M
authors.lastname: Lim
authors.forename: P
authors.initials: P
authors.lastname: Sagar
authors.forename: P
authors.initials: P
authors.lastname: Finan
authors.forename: D
authors.initials: D
authors.lastname: Burke
authors.forename: H
authors.initials: H
authors.lastname: Schuster
mesh_terms: D000465:Algorithms; D003106:Colon / Q000382:microbiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D019449:Pouchitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy