title: [Histological observations of chemically induced acute hepatic injury repaired by allogeneic bone marrow stem cell transplantation].
abstract: OBJECTIVE
  To explore the possibility of repairing chemically induced acute hepatic injuries with allogeneic bone marrow stem cell (BMSC) transplantation.
  
  
  METHODS
  A SD rat model of CCl(4)-induced acute hepatic injury was established, which received transplantation of BMSCs (2.0 ml, 1x10(6)/ml) or normal saline injection into the local liver parenchyma, respectively. The rats were sacrificed at 6 h before and 6 h, 1, and 5 weeks after transplantation, and the livers were prepared for microscopic examination.
  
  
  RESULTS
  Cellular necrosis, bridging necrosis, congestion in the hepatic sinusoid, and inflammatory cell infiltration were seen in the chemically injured livers 6 h after model establishment, and these changes were ameliorated in rats receiving BMSC transplantation.
  
  
  CONCLUSIONS
  Allogeneic BMSC transplantation can repair chemically induced acute liver injuries.
authors.affiliation: Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
authors.forename: Sheng-jun
authors.initials: SJ
authors.lastname: Liu
authors.forename: Chi-hua
authors.initials: CH
authors.lastname: Fang
authors.forename: Xiao-wu
authors.initials: XW
authors.lastname: Chen
authors.forename: Zhen-xiang
authors.initials: ZX
authors.lastname: Rong
authors.forename: Da-jian
authors.initials: DJ
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
chemical_list: D002251:Carbon Tetrachloride