title: A successful IVF-pregnancy in a patient who underwent conservative surgery followed by a regimen of cisplatin, vinblastine and peplomycin to treat an advanced ovarian mixed germ cell tumour: a case report.
abstract: Mixed germ cell tumours of the ovary, one type of malignant ovarian germ cell tumours (MOGCTs), are rare gynaecologic cancers usually affecting young women. We report the case of a patient with an advanced ovarian mixed germ cell tumour who underwent fertility-saving surgery followed by a chemotherapy regimen of cisplatin, vinblastine and peplomycin. The patient was disease-free 8 years after initial presentation. She conceived and gestated dichorionic twins after IVF-embryo transfer. To the best of our knowledge, the patient is the first to be treated successfully with the combination chemotherapy regimen and then conceive safely using assisted reproductive technology (ART).
authors.affiliation: Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kitajima
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Ishioka
authors.forename: T
authors.initials: T
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Honnma
authors.forename: T
authors.initials: T
authors.lastname: Saito
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000601:surgery / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000601:surgery / Q000628:therapy*; D017663:Peplomycin / Q000008:administration & dosage / Q000627:therapeutic use; D010532:Peritoneal Diseases / Q000150:complications / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D000267:Tissue Adhesions; D014427:Twins; D014747:Vinblastine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D017663:Peplomycin; D014747:Vinblastine; D002945:Cisplatin