title: [A case of severe skin eruption caused by lamivudine in a patient with chronic hepatitis B].
abstract: Lamivudine is widely used for the treatment of chronic hepatitis B infection because of it's remarkable antiviral efficacy and safety. We report a case of severe skin eruption caused by lamivudine. A 47-year-old female was admitted because of jaundice and itching sensation. She was diagnosed as chronic hepatitis B infection a few years ago but did not receive any specific treatment. Laboratory data showed acute deterioration of chronic hepatitis B infection. We prescribed lamivudine as a rescue therapy. Her general condition improved and lab data showed improvement in liver function test thereafter. However, she complained of severe skin eruption and itching sensation a few days after the discharge. We stopped lamivudine because the symptoms did not improve despite the use of anti-histamine. Skin biopsy showed interface dermatitis. After stopping lamivudine, her symptoms improved. However, the skin eruption developed again after lamivudine was restarted. Adefovir was used instead, and the patient did not experience any further skin problems since then.
authors.affiliation: Department of Internal Medicine, Dankook University College of Medicine, Anseo-Dong, Cheonan, Korea. sm1213@paran.com
authors.forename: Seok Bae
authors.initials: SB
authors.lastname: Kim
authors.forename: Pyoung Ju
authors.initials: PJ
authors.lastname: Seo
authors.forename: Du San
authors.initials: du S
authors.lastname: Baik
authors.forename: Se Young
authors.initials: SY
authors.lastname: Yun
authors.forename: Byung Ha
authors.initials: BH
authors.lastname: Kim
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Shin
authors.forename: Hong Ja
authors.initials: HJ
authors.lastname: Kim
authors.forename: Il Han
authors.initials: IH
authors.lastname: Song
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D007057:Ichthyosis / Q000139:chemically induced / Q000473:pathology; D019259:Lamivudine / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D019259:Lamivudine; D000225:Adenine; C106812:adefovir dipivoxil