title: Keeping transcriptional activators under control.
abstract: Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this process.
authors.affiliation: Department of Internal Medicine , University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, USA. thomas.kodadek@utsouthwestern.edu
authors.forename: Thomas
authors.initials: T
authors.lastname: Kodadek
authors.forename: Devanjan
authors.initials: D
authors.lastname: Sikder
authors.forename: Kip
authors.initials: K
authors.lastname: Nalley
mesh_terms: D000818:Animals; D006801:Humans; D008957:Models, Genetic; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D013997:Time Factors; D015534:Trans-Activators / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology; D015533:Transcriptional Activation; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D015534:Trans-Activators; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex