Hypolipemic effect of water extracts of Picrorrhiza kurroa in high fat diet treated mouse.
A hypolipemic effect of the water extract of Picrorrhiza kurroa (PR) was observed in a high fat diet feeding hyperlipemic mouse at doses of 50, 100 and 200 mg/kg, orally, once a day for 12 weeks. Liver weight, serum aspartate transferase (AST), alanine transferase (ALT), low density lipoprotein (LDL), triglyceride and total cholesterol levels were significantly reduced by the treatment. On the contrary, serum HDL level seems not affected by P. kurroa water extract.
Lee
Hyeung Sik
HS
Department of Herbal Biotechnology, Daegu Haany University, Gyeongsan, 712-715, Republic of Korea.
Yoo
Choon Bo
CB
Ku
Sae Kwang
SK
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009765:Obesity / Q000188:drug therapy*; D008517:Phytotherapy; D032261:Picrorhiza; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D018547:Plant Stems; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase