STAT3-mediated anti-inflammatory signalling.
IL-1O (interleukin-10) negatively regulates inflammation through a mechanism that blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules required for the full activation of the innate and adaptive immune responses. The signalling pathway used by the IL-10 receptor to generate the anti-inflammatory response requires STAT3 (signal transducer and activator of transcription 3) and is indirect. Thus STAT3 activates other genes whose task is to selectively control transcription of inflammatory targets. Here, I summarize current knowledge of the key features of IL-10 signalling and make predictions concerning the mechanism of IL-10 at the level of inflammatory genes. Understanding IL-10 signalling should be a gateway to the development of broadly acting anti-inflammatory agents.
Murray
P J
PJ
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Peter.murray@stjude.org
D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology; D007249:Inflammation / Q000235:genetics / Q000503:physiopathology* / Q000517:prevention & control*; D016753:Interleukin-10 / Q000276:immunology / Q000502:physiology; D018448:Models, Immunological; D053701:Receptors, Interleukin-10 / Q000276:immunology / Q000502:physiology; D050796:STAT3 Transcription Factor / Q000502:physiology*; D015398:Signal Transduction; D014158:Transcription, Genetic
D053701:Receptors, Interleukin-10; D050796:STAT3 Transcription Factor; D016753:Interleukin-10