title: Complexes of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin. A study of their antimicrobial activity.
abstract: Cobalt(II), nickel(II), copper(II) and zinc(II) complexes of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin (HL(1) and HL(2), respectively) were synthesized and characterized, being the crystal structures of HL(1), HL(2) and [Ni(L(1))(2)].2CHCl(3) elucidated by X-ray diffraction techniques. The in vitro antimicrobial activity of all these compounds was tested against several bacteria and fungi. HL(1)and its complexes exhibited a strong inhibition of the growth of Haemophilus influenzae (MIC 0.15-1.50microg/mL) and good antibacterial properties towards Bacillus subtilis (MIC 3-25microg/mL). The minimal inhibitory concentration (MIC) was defined as the lowest concentration of compound inhibiting the growth of each strain. The antibacterial effectiveness was confirmed against a number of Gram positive bacteria, including methicillin-resistant Staphylococcus aureus. Yeasts and moulds showed a low susceptibility, except the dermatophyte mould Epidermophyton floccosum that is inhibited at concentrations ranging from 6 to 50microg/mL. In general, the antimicrobial activity of the thiophene derivatives was greater than that of the isonicotinic analogues.
authors.affiliation: Departamento de Química Inorgánica, Universidade de Vigo, 36200 Vigo, Spain. mcarmen@uvigo.es
authors.forename: María C
authors.initials: MC
authors.lastname: Rodríguez-Argüelles
authors.forename: Sandra
authors.initials: S
authors.lastname: Mosquera-Vázquez
authors.forename: Patricia
authors.initials: P
authors.lastname: Tourón-Touceda
authors.forename: Jesús
authors.initials: J
authors.lastname: Sanmartín-Matalobos
authors.forename: Ana M
authors.initials: AM
authors.lastname: García-Deibe
authors.forename: Marisa
authors.initials: M
authors.lastname: Belicchi-Ferrari
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pelosi
authors.forename: Corrado
authors.initials: C
authors.lastname: Pelizzi
authors.forename: Franca
authors.initials: F
authors.lastname: Zani
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D006835:Hydrazones; D007211:Indoles; D013876:Thiophenes; C095912:N-methylisatin