Hinokiresinol inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction.
The antiallergic effect of hinokiresinol isolated from the whole plant of TRAPA Pseudoincisa S. at. Z. was measured in vitro and in vivo. Hinokiresinol not only potently inhibited beta-hexosaminidase release from RBL-2H3 cells induced by IgE, with an IC50 value of 98 microM, but also inhibited the proinflammatory cytokines IL-6, IL-4 and TNF-alpha in RBL-2H3 cells stimulated by IgE. Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE.
Bae
Eun-Ah
EA
College of Pharmacy, Kyung Hee University, Seoul, Korea.
Park
Eun-Kyung
EK
Yang
Hye-Joung
HJ
Baek
Nam-In
NI
Kim
Dong-Hyun
DH
D000284:Administration, Oral; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007073:Immunoglobulin E; D020128:Inhibitory Concentration 50; D007274:Injections, Intraperitoneal; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors*; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019684:Magnoliopsida; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy
D018926:Anti-Allergic Agents; D017705:Lignans; D010636:Phenols; C119821:hinokiresinol; D007975:Leukotriene B4; D007073:Immunoglobulin E