Promiscuous interactions between AMPA-Rs and MAGUKs.
What controls the number of AMPA receptors at excitatory synapses? MAGUKs are known to play a critical role in this process, but which ones are involved and when has been contentious. In this issue of Neuron, Elias et al. have elucidated the roles of three MAGUKs, PSD-95, PSD-93, and SAP-102, in the targeting of AMPA receptors to synapses in hippocampal neurons.
Fitzjohn
Stephen M
SM
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom.
Doherty
Andrew J
AJ
Collingridge
Graham L
GL
D000818:Animals; D000076122:Disks Large Homolog 4 Protein; D015536:Down-Regulation / Q000502:physiology; D051528:Guanylate Kinases; D006624:Hippocampus / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology*
D000076122:Disks Large Homolog 4 Protein; C501447:Dlg4 protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C501451:Mpp2 protein, rat; D009479:Neuropeptides; D018091:Receptors, AMPA; C491075:Dlgh3 protein, mouse; D051528:Guanylate Kinases