Synthesis and characterization of (S)-amino alcohol modified M41S as effective material for the enantioseparation of racemic compounds.
A new chiral stationary phase (CSP) was synthesized based on (S)-1-anilino-3-propyl-2-propanol covalently bonded to the mesoporous semi-crystalline material M41S. Direct semipreparative enantioseparation of mandelic acid could be achieved using medium pressure chromatography. Partly separated could also be the enantiomers of 2,2'-dihydroxy-1,1'-binaphthalene, cyanochromene oxide, diethyl tartrate and 2-phenyl propionic acid. The characterization of CSP was accomplished by microanalysis, cross polarized magic angle spinning (CP-MAS) 13C NMR, powder X-ray diffraction (XRD), FTIR, thermo-gravimetric analysis (TGA), N2 adsorption-desorption isotherm, scanning electron microscopy (SEM) and solid reflectance UV-vis spectroscopy. Furthermore the stability of CSP was satisfactory as it could withstand three washing and reuse experiments of enantioseparation of mandelic acid without loss in its performance.
Mayani
Vishal J
VJ
Silicates and Catalysis Discipline, Central Salt and Marine Chemicals Research Institute (CSMCRI), Bhavnagar 364002, Gujarat, India.
Abdi
S H R
SH
Kureshy
R I
RI
Khan
N H
NH
Agrawal
Santosh
S
Jasra
R V
RV
D000605:Amino Alcohols / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D000605:Amino Alcohols