title: Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region.
abstract: The craniofacial region contains many specified tissues including bone, cartilage, muscle, blood vessels and neurons. Defect or dysfunction of the craniofacial tissue after post-cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient's life. Therefore, functional reconstruction of damaged tissues is highly expected. Bone marrow-derived mesenchymal stem cells (BMMSCs) are one of the most well characterized postnatal stem cell populations, and considered to be utilized for cell-based clinical therapies. Here, the current understanding and the potential applications in craniofacial tissue regeneration of BMMSCs are reviewed, and the current limitations and drawbacks are also discussed.
authors.affiliation: Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
authors.forename: W
authors.initials: W
authors.lastname: Sonoyama
authors.forename: T
authors.initials: T
authors.lastname: Yamaza
authors.forename: S
authors.initials: S
authors.lastname: Gronthos
authors.forename: S
authors.initials: S
authors.lastname: Shi
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D016026:Bone Marrow Transplantation; D005145:Face / Q000601:surgery; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D039902:Multipotent Stem Cells / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D012886:Skull / Q000601:surgery; D023822:Tissue Engineering