title: [Pathogenetic substantiation of periodontal disease treatment by photodynamic therapy].
abstract: The action of photodynamic therapy with 1% photoditasine gel upon hemo-microcirculation and oxygen exchange in periodontal disease treatment was studied. The photodynamic therapy increased capillary blood flow by 20-46% and its intensity by 18-64% that promoted trophic normalization of periodontal tissues and improved regulation mechanisms of tissue blood flow in microcirculatory system by enhancing myogenic microvessel activity that normalized tissue blood flow and reduced venous congestion in gingival tissues, increased oxygenation of gingival tissues by 21-47%, decreased the time and speed of oxygen delivery and utilization thus normalizing oxygen metabolism in periodontal tissues. According to the data of fluorescent spectroscopy in case of photodynamic therapy conducting it was established that maximum application time of 1% photoditasine gel is 8-10 minutes. Density of low intensive laser radiation in continuous regime ranged from 80 to 100 J/cm(2) depending upon inflammation severity in periodontium.
authors.forename: E K
authors.initials: EK
authors.lastname: Krechina
authors.forename: N V
authors.initials: NV
authors.lastname: Efremova
authors.forename: V V
authors.initials: VV
authors.lastname: Maslova
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D010510:Periodontal Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D010519:Periodontium / Q000098:blood supply / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: C047635:N-methylglucosamine; D005944:Glucosamine