title: Use of a new hemicellulose dressing (Veloderm) for the treatment of split-thickness skin graft donor sites A within-patient controlled study.
abstract: A multi-centre, open, within-patient controlled study was performed on 23 adult burnt patients to investigate the effectiveness, safety and tolerability of Veloderm in comparison with Algisite M and Jaloskin in split-thickness skin graft donor site care. The areas dressed with Veloderm completely healed within 10-13 days in a significant higher proportion than the other two dressings (47.6% for Veloderm versus 26.3% for Algisite M and 10% for Jaloskin, P<0.03), showing during the whole study less incidence of exudates and of peri-lesional erythema. The aesthetic outcome of the treated lesions after healing was significantly better for Veloderm (P=0.0016). Veloderm) and Jaloskin required very few renewals of the medication during the first week of treatment, while Algisite M needed several multiple re-dressings. Veloderm was judged better than the other two treatments as far as the acceptability (P<0.001), ease of use (P<0.001) and efficacy (P<0.00001). Both pain during application or at removal of dressings and local infections were negligible with all treatments. No scars were formed in any skin donor site. In conclusion Veloderm is a safe and effective dressing for the re-epithelialization of the skin graft donor sites: it showed higher activity than the other two compared dressings.
authors.affiliation: Burn Intensive Care Unit, Bufalini Hospital, Viale Ghirotti 286, I-47023 Cesena, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Melandri
authors.forename: Armando
authors.initials: A
authors.lastname: De Angelis
authors.forename: Roberto
authors.initials: R
authors.lastname: Orioli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ponzielli
authors.forename: Paolo
authors.initials: P
authors.lastname: Lualdi
authors.forename: Nadia
authors.initials: N
authors.lastname: Giarratana
authors.forename: Valentina
authors.initials: V
authors.lastname: Reiner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002056:Burns / Q000601:surgery*; D016022:Case-Control Studies; D002921:Cicatrix; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D017060:Patient Satisfaction; D011134:Polysaccharides / Q000627:therapeutic use*; D016038:Skin Transplantation / Q000379:methods*; D014946:Wound Infection / Q000209:etiology
chemical_list: D011134:Polysaccharides; C007916:hemicellulose