title: Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse.
abstract: Many drugs are used or abused in social contexts without understanding the ramifications of their use. In this study, we examined the effects of a newly popular drug, 5-methoxy-diisopropyltryptamine (5-MEO-DIPT; 'foxy' or 'foxy-methoxy'). Two experiments were performed. In the first, 5-MEO-DIPT (0, 10, or 20 mg/kg) was administered to rats four times on a single day and animals were examined 3 days later. The animals that received 5-MEO-DIPT demonstrated hypothermia during the period of drug administration and delayed mild hyperthermic rebound for at least 48 h. Corticosterone levels in plasma were elevated in a dose-dependent manner compared to saline-treated animals with minor changes in 5-HT turnover and no changes in monoamine levels. In experiment 2, rats were examined in behavioral tasks following either 0 or 20 mg/kg of 5-MEO-DIPT. The animals treated with 5-MEO-DIPT showed hypoactivity and an attenuated response to (+)-methamphetamine-induced stimulation (1 mg/kg). In a test of path integration (Cincinnati water maze), 5-MEO-DIPT-treated animals displayed deficits in performance compared to the saline-treated animals. No differences were noted in the ability of the animals to perform in the Morris water maze or on tests of novel object or place recognition. The data demonstrate that 5-MEO-DIPT alters the ability of an animal to perform certain cognitive tasks, while leaving others intact and disrupts the endocrine system. 5-MEO-DIPT may have the potential to induce untoward effects in humans.
authors.affiliation: Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH 45229-3039, USA. michael.williams@cchmc.org
authors.forename: Michael T
authors.initials: MT
authors.lastname: Williams
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Herring
authors.forename: Tori L
authors.initials: TL
authors.lastname: Schaefer
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Skelton
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Campbell
authors.forename: Jack W
authors.initials: JW
authors.lastname: Lipton
authors.forename: Anne E
authors.initials: AE
authors.lastname: McCrea
authors.forename: Charles V
authors.initials: CV
authors.lastname: Vorhees
mesh_terms: D008735:5-Methoxytryptamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood*; D003627:Data Interpretation, Statistical; D015198:Designer Drugs / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008694:Methamphetamine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013239:Stereotyped Behavior / Q000187:drug effects; D013550:Swimming
chemical_list: D015306:Biogenic Monoamines; D000697:Central Nervous System Stimulants; D015198:Designer Drugs; C033696:5-methoxy-N,N-diisopropyltryptamine; D008735:5-Methoxytryptamine; D008694:Methamphetamine; D003345:Corticosterone