The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses.
Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokines and targets them to degradation via constitutive ligand-independent internalization. Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and placenta to dampen inflammation in tissues and draining lymph nodes.
Borroni
E M
EM
Istituto Clinico Humanitas, Via Manzoni 56, I-20089 Rozzano, Milan, Italy.
Buracchi
C
C
de la Torre
Y Martinez
YM
Galliera
E
E
Vecchi
A
A
Bonecchi
R
R
Mantovani
A
A
Locati
M
M
D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007962:Leukocytes / Q000502:physiology*; D008024:Ligands; D042601:Lymphatic Vessels / Q000502:physiology; D008954:Models, Biological; D054447:Receptors, CCR10; D019707:Receptors, Chemokine / Q000502:physiology*; D017472:Receptors, Interleukin-1 / Q000502:physiology; D000097628:Chemokine Receptor D6
D008024:Ligands; D054447:Receptors, CCR10; D019707:Receptors, Chemokine; D017472:Receptors, Interleukin-1; D000097628:Chemokine Receptor D6