title: The central nervous system in childhood chronic kidney disease.
abstract: Neurodevelopmental deficits in pediatric and adult survivors of childhood onset chronic kidney disease (CKD) have been documented for many years. This paper reviews the available literature on central nervous system involvement incurred in childhood CKD. The studies reviewed include recent work in neuroimaging, electrophysiology, and neuropsychology, along with commentary on school functioning and long-term outcomes. The paper concludes with suggestions for monitoring the neurodevelopmental status and pursuing appropriate early interventions for children with CKD.
authors.affiliation: UNC Kidney Center, University of North Carolina School of Medicine, 7012 Burnett Womack Bldg., CB# 7155, Chapel Hill, NC 27599-7155, USA. Debbie_gipson@med.unc.edu
authors.forename: Debbie S
authors.initials: DS
authors.lastname: Gipson
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Duquette
authors.forename: Phil F
authors.initials: PF
authors.lastname: Icard
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Hooper
mesh_terms: D000124:Achievement; D002490:Central Nervous System / Q000503:physiopathology*; D002648:Child; D002657:Child Development; D003071:Cognition; D003404:Creatinine / Q000097:blood; D004493:Education; D004569:Electroencephalography; D006801:Humans; D007360:Intelligence; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000523:psychology*; D007858:Learning; D008568:Memory; D012574:Schools
chemical_list: D003404:Creatinine