Water soluble complexes of chitosan-g-MPEG and hyaluronic acid.
Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS-g-MPEG) and negatively charged hyaluronic acid (HA). CS-g-MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG-aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS-g-MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS-g-MPEG solution. The highest viscosity was obtained when the charge ratio of CS-g-MPEG/HA was close to 1.0. Small-angle X-ray scattering measurements provided some insights into the lamellar structure of the CS-g-MPEG/HA complex. The CS-g-MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium).
Wu
Jun
J
Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA.
Wang
Xuefen
X
Keum
Jong Kahk
JK
Zhou
Hongwen
H
Gelfer
Mikhail
M
Avila-Orta
Carlos-Alberto
CA
Pan
Hui
H
Chen
Weiliam
W
Chiao
Shu-Min
SM
Hsiao
Benjamin S
BS
Chu
Benjamin
B
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D015394:Molecular Structure; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013696:Temperature; D014783:Viscosity; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D004337:Drug Carriers; D014867:Water; D011092:Polyethylene Glycols; D006820:Hyaluronic Acid; C028210:monomethoxypolyethylene glycol; D048271:Chitosan