title: International quality control survey of neurochemical dementia diagnostics.
abstract: Currently, neurochemical dementia diagnostics (NDD) are increasingly entering routine clinical neurochemistry, offering improved early and differential diagnosis of dementias. However, there is an obvious lack of standardization in pre-analytical sample handling and systematic quality surveys. Therefore, in this study, 14 laboratories in Germany, Austria, and Switzerland were given aliquots of a human cerebrospinal fluid (CSF) sample, and were asked to measure Alzheimer's disease (AD) biomarkers (amyloid beta (Abeta) peptides, total Tau protein, and phosphorylated Tau protein (P-tau(181P))) according to their routine protocols.
  
  
  RESULTS
  The inter-laboratory coefficients of variation of the results obtained by the laboratories participating in this study were in the range of 20-30%. Although the results of this quality control survey are promising, the quality of measurements has to be further optimized.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewczuk
authors.forename: Georg
authors.initials: G
authors.lastname: Beck
authors.forename: Oliver
authors.initials: O
authors.lastname: Ganslandt
authors.forename: Hermann
authors.initials: H
authors.lastname: Esselmann
authors.forename: Florian
authors.initials: F
authors.lastname: Deisenhammer
authors.forename: Axel
authors.initials: A
authors.lastname: Regeniter
authors.forename: Hela-Felicitas
authors.initials: HF
authors.lastname: Petereit
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Tumani
authors.forename: Andreas
authors.initials: A
authors.lastname: Gerritzen
authors.forename: Patrick
authors.initials: P
authors.lastname: Oschmann
authors.forename: Johannes
authors.initials: J
authors.lastname: Schröder
authors.forename: Peter
authors.initials: P
authors.lastname: Schönknecht
authors.forename: Klaus
authors.initials: K
authors.lastname: Zimmermann
authors.forename: Harald
authors.initials: H
authors.lastname: Hampel
authors.forename: Katharina
authors.initials: K
authors.lastname: Bürger
authors.forename: Markus
authors.initials: M
authors.lastname: Otto
authors.forename: Sabine
authors.initials: S
authors.lastname: Haustein
authors.forename: Karin
authors.initials: K
authors.lastname: Herzog
authors.forename: Rainer
authors.initials: R
authors.lastname: Dannenberg
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wurster
authors.forename: Mirko
authors.initials: M
authors.lastname: Bibl
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Maler
authors.forename: Udo
authors.initials: U
authors.lastname: Reubach
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
authors.forename: Jens
authors.initials: J
authors.lastname: Wiltfang
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers; D019411:Clinical Laboratory Techniques / Q000592:standards*; D003625:Data Collection; D003937:Diagnosis, Differential; D005060:Europe; D006801:Humans; D007202:Indicators and Reagents; D010766:Phosphorylation; D011786:Quality Control; D015203:Reproducibility of Results; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D007202:Indicators and Reagents; D016875:tau Proteins