Stereoselective synthesis of 2'-C-methyl-cyclopropyl-fused carbanucleosides as potential anti-HCV agents.
Stereoselective synthesis of 2'-C-methyl-cyclopropyl-fused carbanucleosides was accomplished via stereoselective cyclopropanation, regioselective cleavage of the isopropylidene group, stereoselective Grignard reaction, and cyclic sulfate chemistry. [reaction: see text]
Lee
Jeong A
JA
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Kim
Hea Ok
HO
Tosh
Dilip K
DK
Moon
Hyung Ryong
HR
Kim
Sanghee
S
Jeong
Lak Shin
LS
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002384:Catalysis; D016174:Hepacivirus / Q000187:drug effects*; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013237:Stereoisomerism
D000998:Antiviral Agents; D009705:Nucleosides