title: Topical administration of oleandrin could protect against gentamicin ototoxicity via inhibition of activator protein-1 and c-Jun N-terminal kinase.
authors.forename: Enzo
authors.initials: E
authors.lastname: Emanuele
authors.forename: Valentina
authors.initials: V
authors.lastname: Olivieri
authors.forename: Alessia
authors.initials: A
authors.lastname: Aldeghi
authors.forename: Piercarlo
authors.initials: P
authors.lastname: Minoretti
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000633:toxicity; D002298:Cardenolides / Q000008:administration & dosage* / Q000627:therapeutic use*; D004423:Ear; D005839:Gentamicins / Q000633:toxicity*; D006198:Hair Cells, Auditory / Q000187:drug effects; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors*
chemical_list: D000900:Anti-Bacterial Agents; D002298:Cardenolides; D005839:Gentamicins; D018808:Transcription Factor AP-1; D048031:JNK Mitogen-Activated Protein Kinases; C021065:oleandrin