title: Stereoselective synthesis of N-alkylaziridines from N-chloroamines.
abstract: We report the first racemic and stereoselective synthesis of cis- and trans-N-alkylaziridines viaN-chloroamines; using this methodology an N-3,4,5-trimethoxybenzylaziridine was synthesised and efficiently cleaved, affording the corresponding NH aziridine in high yield.
authors.affiliation: School of Chemical Sciences & Pharmacy, UEA, Norwich, UK NR4 7TJ. s.bew@uea.ac.uk
authors.forename: Sean P
authors.initials: SP
authors.lastname: Bew
authors.forename: D L
authors.initials: DL
authors.lastname: Hughes
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Palmer
authors.forename: Vladimir
authors.initials: V
authors.lastname: Savic
authors.forename: Katy M
authors.initials: KM
authors.lastname: Soapi
authors.forename: Martin A
authors.initials: MA
authors.lastname: Wilson
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D002700:Chloramines / Q000138:chemical synthesis*; D003500:Cyclization; D015394:Molecular Structure; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D001388:Aziridines; D002700:Chloramines; D012997:Solvents; C033132:aziridine