Increased micronucleus frequency after oral administration of cadmium in dogs.
Cadmium (Cd) is a toxic heavy metal that has been classified as a human carcinogen by the International Agency for Research on Cancer. The genotoxic effects of cadmium oxide (CdO) were investigated in cultured dog lymphocytes after a short-term oral CdO administration by the micronucleus (MN) test. The dogs were given 10 mg CdO/kg body weight per day for 3 and 28 d, respectively group I (n = 7) and group II (n = 6). Blood samples were collected at the beginning of feeding and at 4 and 29 d after Cd administration and cultured for 72 h. Whereas no significant increase in the MN frequency in group I was observed (p = 0.398), a significant MN induction with CdO was found in group II (p = 0.028) when compared with initial MN frequencies of dogs in both groups. Our results suggest that CdO might be directly and/or indirectly genotoxic after a monthly oral administration of CdO in dogs.
Dönmez-Altuntas
Hamiyet
H
Department of Medical Biology, Medical Faculty, Erciyes University Kayseri, Turkey.
Hamurcu
Zuhal
Z
Liman
Narin
N
Demirtas
Halil
H
Imamoglu
Nalan
N
D000284:Administration, Oral; D000818:Animals; D019187:Cadmium Compounds / Q000008:administration & dosage* / Q000633:toxicity*; D004249:DNA Damage / Q000187:drug effects; D004285:Dogs; D005260:Female; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D015162:Micronucleus Tests; D023421:Models, Animal; D010087:Oxides / Q000008:administration & dosage* / Q000633:toxicity*
D019187:Cadmium Compounds; D010087:Oxides; C029663:cadmium oxide