Rheological behavior of gels and meloxicam release.
The aim of this work was to identify a gel with suitable organoleptic and rheological properties (spreadability, texture and viscosity) for topical administration, designed to allow fast release of the active principle. The release of Meloxicam (anti-inflammatory agent) from olive oil lipogels was compared with a Carbopol hydrophilic prepared gel. In order to improve the diffusion of the active principle, two different artificial membranes with different pore size were used, before release assays in diffusion cells were compared. Drug released rate were obtained by Higuchi's model. Release rate and rheological properties relations were studied, and the best results were obtained for the gel prepared with an olive oil emulgent (Olivem 900).
Ruiz Martinez
Maria Adolfina
MA
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Granada, E-18071 Granada, Spain. adolfina@ugr.es
López-Viota Gallardo
Julián
J
de Benavides
María Muñoz
MM
de Dios García López-Duran
Juan
J
Gallardo Lara
Visitación
V
D000180:Acrylic Resins; D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004337:Drug Carriers; D004355:Drug Stability; D005782:Gels; D007700:Kinetics; D000077239:Meloxicam; D008567:Membranes, Artificial; D008956:Models, Chemical; D000069463:Olive Oil; D009991:Oscillometry; D010938:Plant Oils / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D016062:Porosity; D012212:Rheology / Q000379:methods; D033081:Shear Strength; D012995:Solubility; D013696:Temperature; D013843:Thiazines / Q000008:administration & dosage / Q000737:chemistry*; D013844:Thiazoles / Q000008:administration & dosage / Q000737:chemistry*; D014783:Viscosity
D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005782:Gels; D008567:Membranes, Artificial; D000069463:Olive Oil; D010938:Plant Oils; D011145:Polyvinyls; D013843:Thiazines; D013844:Thiazoles; C006912:carboxypolymethylene; D000077239:Meloxicam