Semantic hyperpriming in schizophrenic patients: increased facilitation or impaired inhibition in semantic association processing?
Previous studies analyzing semantic priming in schizophrenic patients have reported conflicting results. In the present study, we explored semantic priming in a sample of schizophrenic patients with mild thought disorders. We wondered if distinct cognitive processes, such as facilitation and/or inhibition, underlie semantic hyperpriming and are variously impaired in schizophrenic patients. Using a lexical decision task, we evaluated semantic priming in 15 schizophrenic patients (DSM-IV) with mild thought disorders and 15 healthy controls matched for sex, age, and education level. The task was designed to divide semantic priming into two additive components, namely facilitation effect and inhibition effect. One-sample t-tests were performed to investigate differences in semantic priming, facilitation, and inhibition within each group. ANOVAs were performed to compare the effects of semantic priming, facilitation, and inhibition between groups. Patients displayed greater semantic priming than controls (i.e., hyperpriming), but this was not due to increased facilitation in processing semantically related pairs. On the contrary, hyperpriming was the result of prolonged response time to process semantically unrelated pairs, corresponding to a requirement to inhibit unrelated information. We demonstrated semantic hyperpriming in stabilized schizophrenic patients with mild severity of symptoms. Thus, semantic hyperpriming may be an intrinsic feature of schizophrenia that is not related to the clinical state of patients. Semantic hyperpriming was due to an inhibition effect involved in processing semantically unrelated information not to increased facilitatory effect for related pairs.
Lecardeur
Laurent
L
UMR 6194, CNRS, CEA, Université de Caen and Université Paris V, France. lecardeur@cyceron.fr
Giffard
Bénédicte
B
Laisney
Mickael
M
Brazo
Perrine
P
Delamillieure
Pascal
P
Eustache
Francis
F
Dollfus
Sonia
S
D000328:Adult; D001288:Attention; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D003463:Cues; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D010153:Paired-Associate Learning; D011930:Reaction Time; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology