title: Therapeutic effects of laparoscopic fundoplication for nonerosive gastroesophageal reflux disease.
abstract: OBJECTIVE
  Surgical treatments for nonerosive gastroesophageal reflux disease (NERD) have not been investigated sufficiently. We examined the results of laparoscopic fundoplication for patients with NERD.
  
  
  METHODS
  We performed laparoscopic fundoplication for NERD in 22 patients. The severity of esophageal hiatal hernia, morphology of the cardiac orifice, and results of 24-hour continuous esophageal and gastric pH were evaluated. We used a four-point scale for the improvement rating of postoperative symptoms.
  
  
  RESULTS
  There were 20 patients (91%) with a sliding hiatal hernia, and 21 patients (95%) with a loose cardiac orifice. Seven patients had acid reflux with 4.0% or higher esophageal fraction of time pH below 4. The surgical techniques used were Nissen fundoplication in 10 patients and Toupet fundoplication in 12 patients. Improvement of postoperative heartburn was rated as excellent in 16 patients, good in 5, and fair in 1. The overall efficacy rating was 95%, and discontinuation of proton pump inhibitor (PPI) was possible in 21 patients.
  
  
  CONCLUSIONS
  Our results of performing laparoscopic fundoplication in patients with NERD were excellent. Even if abnormal acid reflux cannot be confirmed preoperatively, sufficient therapeutic efficacy can be expected for patients with esophageal hiatal hernia or a loose cardiac orifice.
authors.affiliation: Department of Surgery, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Omura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kashiwagi
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Yano
authors.forename: Kazuto
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Naruo
authors.initials: N
authors.lastname: Kawasaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
mesh_terms: D000328:Adult; D000368:Aged; D004947:Esophagus / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000379:methods*; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome