[Bioactive isomalabaricane triterpenes isolated from marine sponge Rhabdastrella aff. distincta].
OBJECTIVE
To study the chemical constituents of the marine sponge Rhabdastrella aff. distincta.


METHODS
Compounds were obtained by normal phase silica gel, Sephadex LH-20, reverse phase chromatogrophy and methylation method. These structures were determined on the basis of IR, MS, NMR spectral analysis.


RESULTS
Eight compounds were isolated from bioactive CH3Cl fraction and identified as geoditin A (1), geoditin B (2), stellettin A (5), stellettin B (4), stellettin C (3), stellettinE (7), rhabdastrellic acid A (8) and the methyl ester of stellettin E (6).


CONCLUSIONS
All these compounds were obtained from this species for the first time.
Lu
Fang
F
State Key laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
Lin
Wen-han
WH
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008419:Materia Medica / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D008419:Materia Medica; D012118:Resorcinols; D014315:Triterpenes; C445692:geoditin A; C445693:geoditin B; C452212:stellettin B; C091312:stellettin A