[Preparation of Shuxiong micropellets by centrifugal granulation technology].
OBJECTIVE
To prepare shuxiong micropellets.


METHODS
Shuxiong micropellets were prepared by using a centrifugal granulator. The formulation composition and process factors were optimized investigated by adopting several indices such as size distribution, repose angle, bulk density and friability as indexes.


RESULTS
The optimal process parameters were as follows. The ratio of fine intermediate product and MCC was 3:1 (w/w), the adhesive agent was 3% HMPC solution, the rotating rate of plate was 200 r x min(-1), the blower rate was 15 x 20 L x min(-1), the rate of air flow was 15 L x min(-1), the spray air pressure was 0.5 MPa, the rotating of spray solution pump was 5-25 r x min(-1) and the rotating rate of powder feed machine was 5-25 r x min(-1).


CONCLUSIONS
Under the optimal conditions, micropellets prepared by using centrifugal granulator hadpossessed prefect shape and surface characteristics and the yield of shuxiong pellets was 90.5%.
Song
Hong-Tao
HT
Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China. sohoto@sohu.com
Zhang
Qian
Q
Kong
Lu-Ling
LL
Chen
Da-Wei
DW
He
Zhong-Gui
ZG
D031187:Carthamus tinctorius / Q000737:chemistry; D002482:Cellulose; D002498:Centrifugation / Q000379:methods; D002599:Chalcone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000302:isolation & purification; D004338:Drug Combinations; D005079:Excipients; D036145:Ginsenosides / Q000008:administration & dosage* / Q000302:isolation & purification; D065347:Hypromellose Derivatives; D030004:Ligusticum / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives; D008863:Microspheres; D053723:Panax notoginseng / Q000737:chemistry; D010316:Particle Size; D010636:Phenols / Q000008:administration & dosage* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000008:administration & dosage* / Q000302:isolation & purification; D013678:Technology, Pharmaceutical / Q000379:methods*
D004338:Drug Combinations; D005079:Excipients; D036145:Ginsenosides; D010636:Phenols; D011809:Quinones; C085278:hydroxysafflor yellow A; D065347:Hypromellose Derivatives; D002599:Chalcone; D002482:Cellulose; D008747:Methylcellulose; C109691:microcrystalline cellulose