title: Thallium-201SPECT assessment in the detection of recurrences of treated gliomas and ependymomas.
abstract: BACKGROUND
  The aim of this study was to establish the value of thalium-(201) single-photon emission computed tomography ((201)Tl-SPECT) in the detection of recurrences in the follow-up of patients with treated primary neuroepithelial tumours.
  
  
  METHODS
  Sixty-three (201)Tl-SPECT were performed in 36 patients with glioma (12 males, mean age of 46 +/- 13 years). All patients underwent surgery and adjuvant radiotherapy (and some of them received chemotherapy). All patients were submitted to morphological neuroimaging techniques as well (and (201) Tl-SPECT). Mean follow-up was 18.3 +/- 14.6 months. Gold standard was based on clinical follow-up, therapeutical decisions (at least 4 months after (201)Tl-SPECT) and imaging features.
  
  
  RESULTS
  Sensitivity and specificity of (201)Tl-SPECT to detect glioma recurrences were 90% and 100% respectively and 93% accuracy. Sensitivity and specificity for high grade tumours, were 100% respectively. Due to 4 false negatives, sensitivity and specificity for low grade gliomas were 78% and 100%. In the positive (201)Tl-SPECT group of patients overall survival was 13.64% at the end of the study. The negative (201)Tl-SPECT group had 84.62% overall survival at the end of the study (p = 0.0003). CONCLUSIONS. (201)Tl-SPECT is a valuable and noninvasive diagnostic procedure to detect recurrence or progression disease for treated gliomas and ependymomas. (201)Tl-SPECT has a good correlation with short term prognosis with excellent diagnostic accuracy.
authors.affiliation: Nuclear Medicine Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Caresia
authors.forename: Joan
authors.initials: J
authors.lastname: Castell-Conesa
authors.forename: Montserra
authors.initials: M
authors.lastname: Negre
authors.forename: Antoni
authors.initials: A
authors.lastname: Mestre
authors.forename: Gemma
authors.initials: G
authors.lastname: Cuberas
authors.forename: Anabel
authors.initials: A
authors.lastname: Mañes
authors.forename: Xavier
authors.initials: X
authors.lastname: Maldonado
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003627:Data Interpretation, Statistical; D004806:Ependymoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005188:False Negative Reactions; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D011379:Prognosis; D011879:Radiotherapy Dosage; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D013794:Thallium Radioisotopes; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes