Differential effects of low and high doses of topiramate on consolidation and retrieval of novel object recognition memory in rats.
Topiramate is a new antiepileptic drug proposed to facilitate synaptic inhibition and block excitatory receptors. However, little is known about the effects of topiramate on memory. In the first experiment, intraperitoneal injection of topiramate at doses of 10.0 and 100.0 mg/kg, immediately after training, induced a deficit in short-term memory (STM) of a novel object recognition (NOR) task tested 1.5 hours after training in rats. In a long-term memory (LTM) test given to the same rats 24 hours after training, topiramate 0.1mg/kg enhanced, whereas 10.0 and 100.0 mg/kg impaired, NOR retention. In the second experiment, administration of topiramate 0.01 and 0.10 mg/kg 1 hour prior to the LTM retention test improved NOR retention, whereas 10.0 and 100.0 mg/kg produced retrieval deficits. The results indicate that low doses of topiramate improve, whereas high doses impair, consolidation and retrieval of recognition memory in rats.
Martins de Lima
Maria Noemia
MN
Graduate Program in Biomedical Gerontology, Institute for Geriatrics and Gerontology, São Lucas Hospital, Pontifical Catholic University, 90619-900 Porto Alegre, RS, Brazil.
Presti-Torres
Juliana
J
Dornelles
Arethuza
A
Bromberg
Elke
E
Schröder
Nadja
N
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D011939:Mental Recall / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects*; D012153:Retention, Psychology / Q000187:drug effects*; D018709:Statistics, Nonparametric; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose