[Research on gene expression of warm-hot drug treating cold syndrome].
OBJECTIVE
To study the therapeutic molecular mechanism of the warm-hot drugs treating cold syndrome.


METHODS
A brother and his sister with deficiency-cold syndrome were chosen and treated with appropriate Chinese formula consisted chiefly of warm-hot drugs for 45 days. Then microarray technique was applied for comparing the gene expression difference of sister who had significant effect, the data was dialed with multiple analysis method and the results were mined though gene function and pathway.


RESULTS
276 differential genes were obtained, which were related to metabolism and 18 pathways.


CONCLUSIONS
Warm-hot drugs work on the gene expression of metabolism. It may be exerting the curative action by gene network and there is distinct difference between gene expression of curative effect and syndrome.
Wu
Bin
B
Institute of Integrative Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200040 China.
Yang
Li-ping
LP
Zhang
Tian-e
TE
Xu
Jin-wen
JW
Wang
Mi-qu
MQ
D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008516:Medicine, Chinese Traditional; D020411:Oligonucleotide Array Sequence Analysis; D013577:Syndrome; D016711:Yang Deficiency / Q000188:drug therapy / Q000235:genetics*
D004365:Drugs, Chinese Herbal