Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs.
OBJECTIVE
In the present study, the contractile response to norepinephrine (NE) and relaxing response to histamine and leukotriene D(4) (LTD(4)) were compared among the nasal mucosae of septa (S) and lateral (L) and medial turbinates (M) isolated from naive male Hartley guinea pigs.


METHODS
The isometrical tension of the isolated nasal mucosae of the above regions was measured at a resting tension of 0.5 g by using a standard organ-bath technique.


RESULTS
In each mucosal strip, NE induced a contraction in a concentration-dependent manner. A significant difference in efficacy (maximal response) of NE was found (L>M>S). In mucosal strips precontracted with NE (3x10(-5)M), both histamine and LTD(4) induced relaxing responses. The efficacy of histamine in S was significantly greater than those in L and M. The potency order of LTD(4) was L>M>S; a significant difference was observed between L and S.


CONCLUSIONS
In conclusion, the present study demonstrated a distinct regional difference in the response to contractile and relaxant agonists of isolated nasal mucosae of guinea pigs.
Chiba
Yoshihiko
Y
Department of Pharmacology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. chiba@hoshi.ac.jp
Matsuo
Kensuke
K
Sakai
Hiroyasu
H
Abe
Kazuho
K
Misawa
Miwa
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D017998:Leukotriene D4 / Q000494:pharmacology*; D008297:Male; D009297:Nasal Mucosa / Q000098:blood supply*; D009300:Nasal Septum / Q000098:blood supply; D009638:Norepinephrine / Q000494:pharmacology*; D014420:Turbinates / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D017998:Leukotriene D4; D006632:Histamine; D009638:Norepinephrine