Overexpression of prolactin receptors during intrahepatic transplantation of RS1 rat cholangiocellular carcinoma cells.
Immunohistochemical study showed that expression of prolactin receptors in intrahepatically transplanted cells of RS1 cholangiocellular carcinoma 2-fold exceeds that in cholangiocytes of intact rats. The number of prolactin receptors significantly increased in tumor cell nuclei of male and female animals. The RS1 transplant induced overexpression of prolactin receptors in hepatocytes and increased their number in nuclei of these cells.
Ostroukhova
T Yu
TY
Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University. ostroukhova_t@yahoo.co.uk
Kulikov
A V
AV
Rozenkrants
A A
AA
Smirnova
O V
OV
D000818:Animals; D018281:Cholangiocarcinoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011981:Receptors, Prolactin / Q000378:metabolism*
D011981:Receptors, Prolactin