title: "Hippocrates-mst": a prototype for computer-aided microcalcification analysis and risk assessment for breast cancer.
abstract: One of the most common cancer types among women is breast cancer. Regular mammographic examinations increase the possibility for early diagnosis and treatment and significantly improve the chance of survival for patients with breast cancer. Clustered microcalcifications have been considered as important indicators of the presence of breast cancer. We present "Hippocrates-mst", a prototype system for computer-aided risk assessment of breast cancer. Our research has been focused in developing software to locate microcalcifications on X-ray mammography images, quantify their critical features and classify them according to their probability of being cancerous. A total of 260 cases (187 benign and 73 malignant) have been examined and the performance of the prototype is presented through receiver operating characteristic (ROC) analysis. The system is showing high levels of sensitivity identifying correctly 98.63% of malignant cases.
authors.affiliation: Laboratory of Informatics, Academy of Athens, 4 Soranou Efesiou, 115 27, Athens, Greece. gspyrou@bioacademy.gr
authors.forename: George
authors.initials: G
authors.lastname: Spyrou
authors.forename: Smaragda
authors.initials: S
authors.lastname: Kapsimalakou
authors.forename: Antonis
authors.initials: A
authors.lastname: Frigas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Koufopoulos
authors.forename: Stamatios
authors.initials: S
authors.lastname: Vassilaros
authors.forename: Panos
authors.initials: P
authors.lastname: Ligomenides
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D002114:Calcinosis / Q000000981:diagnostic imaging*; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D008327:Mammography; D012372:ROC Curve; D011857:Radiographic Image Interpretation, Computer-Assisted; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D012984:Software