title: Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation.
abstract: OBJECTIVE
  To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation.
  
  
  METHODS
  Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique.
  
  
  RESULTS
  Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P < 0.01). There was no difference between high- and low-grade gastric carcinoma (P > 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05).
  
  
  CONCLUSIONS
  IGFBP-2 may be involved in carcino-genesis and progression of gastric carcinoma by promoting cell proliferation.
authors.affiliation: Department of Surgery, Affiliated Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China. slh1020@tom.com
authors.forename: Liang-Hui
authors.initials: LH
authors.lastname: Shi
authors.forename: Xiao-Qun
authors.initials: XQ
authors.lastname: Zhu
authors.forename: Guo-Hai
authors.initials: GH
authors.lastname: Zhao
authors.forename: Ya-Bin
authors.initials: YB
authors.lastname: Xia
authors.forename: Yi-Sheng
authors.initials: YS
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000235:genetics / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000235:genetics / Q000378:metabolism; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*
chemical_list: D018971:Insulin-Like Growth Factor Binding Protein 2; D019394:Ki-67 Antigen