Efficacy of cellulose triacetate dialyzer and polysulfone synthetic hemofilter for continuous venovenous hemofiltration in acute renal failure.
OBJECTIVE
To compare the clearance performances and biocompatibility between the modified cellulose membrane and the standard synthetic membrane in continuous renal replacement therapy (CRRT).


METHODS
Seventeen patients with acute renal failure (ARF) were treated with separated continuous veno venous hemofiltration (CVVH) system conducted with the pre-dilution mode. The modified cellulose used was a Sureflux150E (cellulose triacetate) and the standard synthetic membranes used was an AV-400. Blood and replacement flow rate were kept at 100 and 20 mL/min, respectively. Ultrafiltraion rate was 1,200 mL/hr. Samplings of blood and ultrafiltrate were collected at baseline, 2, 8, 16, and 24 hr.


RESULTS
Patients in both methods could similarly tolerate CRRT with only minor complications. Sureflux 150E and AV-400 provided comparable values of sieving coefficients and clearances of small solutes. The albumin loss in ultrafiltrate by Sureflux 150E was greater than AV-400. The values of life span and biocompatability of both hemofilters were not different.


CONCLUSIONS
Because of the excellent efficacy and the much cheaper cost, the modified cellulose membrane could be an appropriate alternative to standard synthetic membrane in CRRT.
Pichaiwong
Warangkana
W
Department of Medicine, Sirindhorn Hospital.
Leelahavanichkul
Asada
A
Eiam-ong
Somchai
S
D058186:Acute Kidney Injury / Q000097:blood / Q000628:therapy*; D000704:Analysis of Variance; D002482:Cellulose / Q000031:analogs & derivatives*; D003404:Creatinine / Q000097:blood; D005260:Female; D017583:Hemodiafiltration / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D011446:Prospective Studies; D006435:Renal Dialysis; D017582:Renal Replacement Therapy / Q000295:instrumentation* / Q000379:methods; D012709:Serum Albumin / Q000032:analysis; D013450:Sulfones; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
D008567:Membranes, Artificial; D011108:Polymers; D012709:Serum Albumin; D013450:Sulfones; C017662:polysulfone P 1700; D014527:Uric Acid; D014508:Urea; D002482:Cellulose; C024671:cellulose triacetate; D003404:Creatinine