title: Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon4 carriers.
abstract: Apolipoprotein E-epsilon4 is the main known genetic risk factor for Alzheimer's disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer's disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at-risk persons. We studied nondemented apolipoprotein E-epsilon4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-epsilon4 carriers, and hence likely progression to Alzheimer's disease.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institute, MR Research Center, Karolinska Hospital, and Department of Psychology, Stockholm University, Stockholm, Sweden. Johanna.lind@ki.se
authors.forename: Johanna
authors.initials: J
authors.lastname: Lind
authors.forename: Martin
authors.initials: M
authors.lastname: Ingvar
authors.forename: Jonas
authors.initials: J
authors.lastname: Persson
authors.forename: Kristel
authors.initials: K
authors.lastname: Sleegers
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Rolf
authors.initials: R
authors.lastname: Adolfsson
authors.forename: Lars-Göran
authors.initials: LG
authors.lastname: Nilsson
authors.forename: Lars
authors.initials: L
authors.lastname: Nyberg
mesh_terms: D000368:Aged; D053327:Apolipoprotein E4 / Q000235:genetics*; D001931:Brain Mapping; D005260:Female; D006579:Heterozygote; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology*; D011237:Predictive Value of Tests
chemical_list: D053327:Apolipoprotein E4