Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor.
A cell permeable DPP II [also known as DPP2, DPP7, and quiescent cell proline dipeptidase (QPP)] inhibitor has been synthesized. The azabicyclo[3.3.0]octane-based inhibitor is potent and selective and elicits very similar quiescent lymphocyte death to previously characterized inhibitors that are not as selective.
Danilova
Olga
O
Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA.
Li
Bei
B
Szardenings
A Katrin
AK
Huber
Brigitte T
BT
Rosenblum
Jonathan S
JS
D017209:Apoptosis / Q000187:drug effects; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000037:antagonists & inhibitors*; D006801:Humans; D066298:In Vitro Techniques; D019169:Jurkat Cells; D007700:Kinetics; D008214:Lymphocytes / Q000187:drug effects; D009795:Octanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*
D001372:Aza Compounds; D009795:Octanes; D011480:Protease Inhibitors; C518626:azabicyclo(3.3.0)-octane; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; C100151:dipeptidyl peptidase II