title: Inhibitors of sphingolipid metabolism enzymes.
abstract: Sphingolipids are a family of lipids that play essential roles both as structural cell membrane components and in cell signalling. The cellular contents of the various sphingolipid species are controlled by enzymes involved in their metabolic pathways. In this context, the discovery of small chemical entities able to modify these enzyme activities in a potent and selective way should offer new pharmacological tools and therapeutic agents.
authors.affiliation: Research Unit on Bioactive Molecules (RUBAM), Department of Biological Organic Chemistry, Chemical and Environmental Research Institute of Barcelona, (IIQAB-C.S.I.C), Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Delgado
authors.forename: Josefina
authors.initials: J
authors.lastname: Casas
authors.forename: Amadeu
authors.initials: A
authors.lastname: Llebaria
authors.forename: José Luís
authors.initials: JL
authors.lastname: Abad
authors.forename: Gemma
authors.initials: G
authors.lastname: Fabrias
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism; D055572:Ceramidases; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000378:metabolism; D051102:Serine C-Palmitoyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013107:Sphingolipids / Q000378:metabolism*; D000099157:Sphingosine Kinase
chemical_list: D000581:Amidohydrolases; D055572:Ceramidases; D004791:Enzyme Inhibitors; D010088:Oxidoreductases; D017853:Phosphotransferases (Alcohol Group Acceptor); D051102:Serine C-Palmitoyltransferase; D013107:Sphingolipids; D000099157:Sphingosine Kinase; C108138:dihydroceramide desaturase; C066324:ceramide kinase