RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.
Santoro
Massimo
M
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR 'G. Salvatore', c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Via S. Pansini, 5, 80131 Naples, Italy. masantor@unina.it
Melillo
Rosa Marina
RM
Fusco
Alfredo
A
D000818:Animals; D002291:Carcinoma, Papillary / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement / Q000235:genetics*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*; D015533:Transcriptional Activation
D015514:Oncogene Proteins, Fusion; D011505:Protein-Tyrosine Kinases; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; C093573:ret-PTC fusion oncoproteins, human