title: Polycystic ovaries after precocious pubarche: relation to prenatal growth.
abstract: BACKGROUND
  In 1998, we revealed a sequence departing from prenatal growth restraint in girls and evolving, through precocious pubarche (PP) in mid-childhood, towards anovulatory and hyperinsulinaemic hyperandrogenism. The latter condition fulfilled the criteria for the diagnosis of polycystic ovary syndrome (PCOS), which was then defined independently of the presence of polycystic ovaries (PCOs). Since 2003, the diagnosis of PCOS has been extended by adding PCO as an alternative criterion. We verified longitudinally over 28 +or- 2 years the prevalence of PCO and its potential relationship to growth before birth in a group of post-PP women (n=14, mean age=28 years; body mass index=24.3 kg/m2) belonging to the original cohort of 35 girls in whom the PP-PCOS sequence was described.
  
  
  METHODS
  Endocrine-metabolic variables, body composition (by dual-energy X-ray absorptiometry), carotid intima-media thickness (IMT) and ovarian morphology by transvaginal ultrasonography were assessed in all women.
  
  
  RESULTS
  Post-PP women with a birthweight (BW) in the lowest quartile, when compared with post-PP women with a higher BW, had smaller ovaries (mean volume=4.0 versus 9.0 ml; P=0.004) and a much lower prevalence of PCO (0 versus 67%; P=0.006). The remaining variables were similar between BW subgroups.
  
  
  CONCLUSIONS
  The presence of a PCO morphology in women with a PP history was found to relate to prenatal growth. It would be of interest to verify whether a similar relationship exists in anovulatory and/or hyperandrogenic women without PP history.
authors.affiliation: Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain. libanez@hsjdbcn.org
authors.forename: L
authors.initials: L
authors.lastname: Ibáñez
authors.forename: A
authors.initials: A
authors.lastname: Jaramillo
authors.forename: G
authors.initials: G
authors.lastname: Enríquez
authors.forename: E
authors.initials: E
authors.lastname: Miró
authors.forename: A
authors.initials: A
authors.lastname: López-Bermejo
authors.forename: D
authors.initials: D
authors.lastname: Dunger
authors.forename: F
authors.initials: F
authors.lastname: de Zegher
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002648:Child; D005260:Female; D006801:Humans; D010053:Ovary / Q000000981:diagnostic imaging; D011085:Polycystic Ovary Syndrome / Q000196:embryology*; D011629:Puberty, Precocious / Q000503:physiopathology*; D018608:Ultrasonography, Doppler