title: [IGF-1 plasma levels evaluation in prolactinoma].
abstract: Prolactinomas are the most frequent pituitary tumors and may co-secrete GH (growth hormone). IGF-1 (insulin-like growth factor-1) is the main responsible for GH actions and a parameter for the diagnosis of acromegaly. With the objective of identifying through a IGF-1 levels analysis, in the initial evaluation of prolactinoma patients, the existence of mixed tumors [GH and prolactin (PRL)], we studied 7 men and 27 women, aged between 19 and 72 years, confronting them with the results of basal and glucose stimulated (glucose tolerance test--GTT) GH levels, indicated when GH >0.4 ng/mL or IGF-1 levels were elevated. The prevalence of patients with GH >0.4 ng/mL and elevated IGF-1 was higher than expected; however, after GTT, no patient fulfilled the diagnostic criteria for acromegaly. However, we suggest that, they should be submitted to IGF-1 evaluation, due to the risk of GH co-secretion in prolactinomas. Special attention should be paid to those who present a significant decrease of PRL levels without concomitant tumor size reduction.
authors.affiliation: Hospital Universitario Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil.
authors.forename: Daniela
authors.initials: D
authors.lastname: Zylberberg
authors.forename: Erika C O
authors.initials: EC
authors.lastname: Naliato
authors.forename: Alair
authors.initials: A
authors.lastname: Sarmet
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sato
authors.forename: Fernando S R
authors.initials: FS
authors.lastname: Costa
authors.forename: Alice H D
authors.initials: AH
authors.lastname: Violante
mesh_terms: D000172:Acromegaly / Q000209:etiology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood* / Q000150:complications; D015175:Prolactinoma / Q000097:blood* / Q000150:complications; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D007334:Insulin-Like Growth Factor I