DDS for anti-aging and regenerative medicine (review).
In this paper we summarized, first the present status and history of the development of research in anti-aging and regenerative medicine in Japan, and secondly some of our research using DDS in the field of both medicine. The regenerative medicine has been developed in Japan by using the fund from the Government, particularly as the Millennium Project. While anti-aging medicine developed following the social interest on it in Japan and it was influenced by American Society (A4M). Next, we summarized our research on DDS for anti-aging and regenerative medicine. In most cases we used oily or solid nanoparticles as carriers of drug. Those particles have a property of both of targeting and slow release in the DDS technology. The two properties are important for anti-aging and regenerative medicine, since drugs have to be administered safely and for long time. We applied prostaglandin E1, granulocyte-colony stimulate factor (G-CSF), and retinoid into the systems.
Mizushima
Y
Y
Institute of DDS, Jikei University School of Medicine, Tokyo, 105-6201, Japan.
Hoshi
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K
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000527:Alprostadil / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D044968:Regenerative Medicine / Q000379:methods*
D004364:Pharmaceutical Preparations; D016179:Granulocyte Colony-Stimulating Factor; D000527:Alprostadil