Patent ductus arteriosus in extremely preterm infants receiving phototherapy: does shielding the chest make a difference? A randomized, controlled trial.
BACKGROUND
Patent ductus arteriosus (PDA), a common complication in extremely preterm infants, is associated with increased mortality and morbidity. Phototherapy has been associated with PDA, and one randomized, control trial has shown that shielding of the chest may decrease the risk of PDA.


OBJECTIVE
To examine if chest shielding reduces the incidence and severity of PDA in extremely preterm infants.


METHODS
Randomized clinical trial of infants < 29 wk gestation (stratified into two groups: < 27 wk gestation and 27-28 wk gestation).


METHODS
Following written parental consent, eligible infants were randomized to receive phototherapy, with or without a chest shield. Ductal parameters were assessed by Doppler echocardiogram in all infants prior to starting phototherapy and at 48 h after initiation, or earlier if phototherapy was discontinued.


RESULTS
54 infants were enrolled in the study. The incidence of PDA (shield 19/27 vs no shield 21/27), ductal size (1.4 vs 1.0 mm) and left atrial/aortic root (LA/Ao) ratio (1.2 vs 1.3) were similar in the two groups pre-phototherapy. There was no difference between the groups post-phototherapy in incidence (shield 12/27 vs no shield 13/27), ductal size (1.4 vs 1.5 mm) or LA/Ao ratio (1.1 vs 1.3).


CONCLUSIONS
Chest shielding did not alter the incidence or severity of PDA in our population of extremely preterm infants.
Travadi
Javeed
J
Women's and Children's Health Service, Subiaco, WA, Australia. javeed.travadi@hnehealth.nsw.gov.au
Simmer
Karen
K
Ramsay
James
J
Doherty
Dorota
D
Hagan
Ronald
R
D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000628:therapy*; D008297:Male; D010789:Phototherapy / Q000379:methods*; D011835:Radiation Protection; D013909:Thorax / Q000528:radiation effects