title: EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes.
abstract: EPConDB (http://www.cbil.upenn.edu/EPConDB) is a public web site that supports research in diabetes, pancreatic development and beta-cell function by providing information about genes expressed in cells of the pancreas. EPConDB displays expression profiles for individual genes and information about transcripts, promoter elements and transcription factor binding sites. Gene expression results are obtained from studies examining tissue expression, pancreatic development and growth, differentiation of insulin-producing cells, islet or beta-cell injury, and genetic models of impaired beta-cell function. The expression datasets are derived using different microarray platforms, including the BCBC PancChips and Affymetrix gene expression arrays. Other datasets include semi-quantitative RT-PCR and MPSS expression studies. For selected microarray studies, lists of differentially expressed genes, derived from PaGE analysis, are displayed on the site. EPConDB provides database queries and tools to examine the relationship between a gene, its transcriptional regulation, protein function and expression in pancreatic tissues.
authors.affiliation: Department of Genetics, School of Medicine, Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Joan M
authors.initials: JM
authors.lastname: Mazzarelli
authors.forename: John
authors.initials: J
authors.lastname: Brestelli
authors.forename: Regina K
authors.initials: RK
authors.lastname: Gorski
authors.forename: Junmin
authors.initials: J
authors.lastname: Liu
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Manduchi
authors.forename: Deborah F
authors.initials: DF
authors.lastname: Pinney
authors.forename: Jonathan
authors.initials: J
authors.lastname: Schug
authors.forename: Peter
authors.initials: P
authors.lastname: White
authors.forename: Klaus H
authors.initials: KH
authors.lastname: Kaestner
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Stoeckert
mesh_terms: D000818:Animals; D001665:Binding Sites; D030541:Databases, Genetic; D003920:Diabetes Mellitus / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D020407:Internet; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D010179:Pancreas / Q000254:growth & development / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D012984:Software; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D014584:User-Computer Interface
chemical_list: D014157:Transcription Factors