title: D-serine in the developing human central nervous system.
abstract: To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development.
authors.affiliation: Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. s.fuchs@umcutrecht.nl
authors.forename: Sabine A
authors.initials: SA
authors.lastname: Fuchs
authors.forename: Lambertus
authors.initials: L
authors.lastname: Dorland
authors.forename: Monique G
authors.initials: MG
authors.lastname: de Sain-van der Velden
authors.forename: Margriet
authors.initials: M
authors.lastname: Hendriks
authors.forename: Leo W J
authors.initials: LW
authors.lastname: Klomp
authors.forename: Ruud
authors.initials: R
authors.lastname: Berger
authors.forename: Tom J
authors.initials: TJ
authors.lastname: de Koning
mesh_terms: D002490:Central Nervous System / Q000254:growth & development* / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005998:Glycine / Q000134:cerebrospinal fluid / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D050543:Phosphoglycerate Dehydrogenase / Q000172:deficiency; D012694:Serine / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000502:physiology*; D013237:Stereoisomerism
chemical_list: D012694:Serine; D050543:Phosphoglycerate Dehydrogenase; D005998:Glycine