[PEA3 family of transcription factors and the regulation of oncogenesis].
Erm, Er81, and Pea3 are the three members of the PEA3 group which belong to the Ets transcription factors family. These proteins regulate transcription of multiple target genes, such as those encoding several matrix metalloproteinases (MMP), which are enzymes degrading the extracellular matrix during cancer metastasis. In fact, PEA3-group genes are often overexpressed in different types of human cancers that also over-express these MMP and display a disseminating phenotype. In experimental models, regulation of PEA3 group member expression has been shown to influence the metastatic process, thus suggesting that these factors play a key role in metastasis.
de Launoit
Yvan
Y
UMR 8161, Institut de Biologie de Lille, CNRS, Université de Lille I, Université de Lille II, Institut Pasteur de Lille, BP447, 1 rue Calmette, 59021 Lille Cedex. yvan.delaunoit@ibl.fr
Baert
Jean-Luc
JL
Chotteau-Lelievre
Anne
A
Monte
Didier
D
Coutte
Laurent
L
Mauen
Sébastien
S
Firlej
Virginie
V
Degerny
Cindy
C
Verreman
Kathye
K
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D051379:Mice; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; C095239:ETV1 protein, human; D009363:Neoplasm Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors; C065788:transcription factor PEA3; D020782:Matrix Metalloproteinases