title: Nesiritide for treatment of perioperative low cardiac output syndromes in cardiac surgical patients: an initial experience.
abstract: The physiologic properties of the b-type natriuretic peptide nesiritide include pulmonary, coronary, and renal arterial vasodilation and lusitropic effects on ventricular myocardium. These effects may be useful during cardiac surgery, particularly when myocardial function and cardiac output (CO) are compromised. Intraoperative hemodynamic data were collected retrospectively before and 5-15 min following completion of a nesiritide loading dose in 15 adult cardiac surgical patients with low CO associated with pulmonary hypertension, low left ventricular ejection fraction, diastolic dysfunction, or left ventricular assist device placement. In seven patients, prior alternative pharmacologic interventions had failed to improve CO, and fluid challenges were ineffective in six patients with diastolic dysfunction. Perioperative nesiritide administration (2 microg.kg(-1) load, followed by 0.01 microg.kg(-1).min(-1) for a maximum of 24 h) resulted in a statistically significant median increase in CO of 35% (P = 0.0006). In conclusion, nesiritide was associated with increased CO in patients with low CO syndromes undergoing cardiac surgery, when other measures failed. This novel agent may offer an additional option to inotropes and fluid challenges for these patients perioperatively. Randomized clinical trials are desirable to determine the risks and benefits of nesiritides and to elucidate its role for the cardiac anesthesiologist.
authors.affiliation: Department of Anesthesia, Division of Cardiac Surgery, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Gordon
authors.forename: Roman
authors.initials: R
authors.lastname: Schumann
authors.forename: Hassan
authors.initials: H
authors.lastname: Rastegar
authors.forename: Kamal
authors.initials: K
authors.lastname: Khabbaz
authors.forename: Michael R
authors.initials: MR
authors.lastname: England
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002248:Carbon Monoxide / Q000032:analysis; D002303:Cardiac Output, Low / Q000503:physiopathology / Q000628:therapy*; D006348:Cardiac Surgical Procedures; D017548:Echocardiography, Transesophageal; D005260:Female; D006353:Heart-Assist Devices; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D045283:Natriuretic Agents / Q000627:therapeutic use*; D020097:Natriuretic Peptide, Brain / Q000627:therapeutic use*; D019990:Perioperative Care; D012189:Retrospective Studies
chemical_list: D045283:Natriuretic Agents; D020097:Natriuretic Peptide, Brain; D002248:Carbon Monoxide