Comparison of creatinine clearance estimates with routine measured clearance.
OBJECTIVE
Compare GFR estimates (eGFR) calculated by formulas (CG, CGI, MDRD) and creatinine clearance (CrCl), in subgroups based on sex, age, BMI and serum creatinine (Cr).


METHODS
eGFR is calculated with Cockgroft-Gault (CG), CG corrected for ideal or lean weight (CGI), and Modification of Diet in Renal Disease (MDRD) formulas using a compensated kinetic Jaffé method. Comparison of means and correlations relative to CrCl is done with 666 male and female adult subjects in different subgroups.


RESULTS
Comparatively to CrCl, most subgroups are best correlated with MDRD, especially with high Cr. However, in men <65 years, a factor of 222, instead of 186 in MDRD formula, is better.


CONCLUSIONS
eGFR from MDRD formula, modified for men <65 years, is better correlated to CrCl.
Planet
Guy
G
Service de biochimie, CH Anna Laberge, Biochimie, 200 Brisebois, Châteauguay (Qc), Canada J6K 4W8. guy.planet@rrsss16.gouv.qc.ca
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000032:analysis*; D005260:Female; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged
D003404:Creatinine