[Incretins].
Insulin secretion is greater after peroral challenge than after intravenous glucose administration due to so-called incretin effect. The major incretins are glucagon-like peptide 1 and glucose-dependent-insulinotropic peptide. Physiology, pathophysiology and therapeutic implications of incretins in diabetes, neurodegenerative disorders and stress-induced hyperglycemia are concerned.
Vrbíková
J
J
Endokrinologický ustav, Praha. jvrbikova@endo.cz
Vondra
K
K
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D005749:Gastric Inhibitory Polypeptide / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000502:physiology*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology / Q000628:therapy; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion
D007328:Insulin; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1