title: Enhanced baroreceptor control of the cardiovascular system by polyunsaturated Fatty acids in heart failure patients.
abstract: OBJECTIVE
  The intention of this study was to test the hypothesis that, in heart failure patients, dietary supplementation of polyunsaturated fatty acids (PUFA) enhances arterial baroreceptor control of the cardiovascular system.
  
  
  BACKGROUND
  Administration of PUFA reduces the risk of life-threatening arrhythmias in patients surviving myocardial infarction. This might result from potentiation of arterial baroreflexes, but whether or not PUFA enhance baroreflex function has never been studied in humans.
  
  
  METHODS
  Patients with post-myocardial infarction left ventricular dysfunction underwent beat-to-beat blood pressure (BP) (Finapres, Ohmeda Inc., Englewood, Colorado) and R-R interval (electrocardiogram) recording; baroreceptor reflexes were assessed from the bradycardic and depressor responses to graded neck suction (NS) as well as by computation of the alpha "spontaneous" baroreflex sensitivity index. Assessments were repeated after prolonged treatment with PUFA (2 g/die, n = 15) or placebo (n = 10).
  
  
  RESULTS
  Baseline BP and R-R interval were unaffected by PUFA. Both reflex depressor and bradycardic responses to NS increased after PUFA (respectively from -0.09 +/- 0.01 to -0.16 +/- 0.01 mm Hg x mm Hg(-1), p < 0.01, and from 1.25 +/- 0.9 to 1.76 +/- 1.1 ms x mm Hg(-1), p < 0.04) but not after placebo. The spontaneous baroreflex sensitivity increased in the PUFA (from 8.99 +/- 1.4 to 12.2 +/- 1.2 ms x mm Hg(-1), p < 0.02) but not in the placebo group. Polyunsaturated fatty acids (but not placebo) treatment also significantly increased R-R interval total variance and low-frequency and high-frequency spectral powers.
  
  
  CONCLUSIONS
  Dietary PUFA supplementation markedly potentiates baroreflex function and enhances heart rate variability in patients with stable congestive heart failure.
authors.affiliation: Divisione di Riabilitazione Cardiologica, Ospedale San Gerardo, Monza, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Radaelli
authors.forename: Maria
authors.initials: M
authors.lastname: Cazzaniga
authors.forename: Andrea
authors.initials: A
authors.lastname: Viola
authors.forename: Giulia
authors.initials: G
authors.lastname: Balestri
authors.forename: Maria Bianchi
authors.initials: MB
authors.lastname: Janetti
authors.forename: Maria G
authors.initials: MG
authors.lastname: Signorini
authors.forename: Paolo
authors.initials: P
authors.lastname: Castiglioni
authors.forename: Arianna
authors.initials: A
authors.lastname: Azzellino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mancia
authors.forename: Alberto U
authors.initials: AU
authors.lastname: Ferrari
mesh_terms: D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000503:physiopathology*; D019587:Dietary Supplements; D005231:Fatty Acids, Unsaturated / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications; D009333:Neck; D010812:Physical Stimulation; D011311:Pressoreceptors / Q000187:drug effects* / Q000503:physiopathology*; D013396:Suction
chemical_list: D005231:Fatty Acids, Unsaturated