title: Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene.
abstract: Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are co-morbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia.
authors.affiliation: Department of Epidemiology of Joseph L. Mailman School of Public Health, Columbia University, New York, New York 10032, USA. gah13@columbia.edu
authors.forename: Gary A
authors.initials: GA
authors.lastname: Heiman
authors.forename: Ruth
authors.initials: R
authors.lastname: Ottman
authors.forename: Rachel J
authors.initials: RJ
authors.lastname: Saunders-Pullman
authors.forename: Laurie J
authors.initials: LJ
authors.lastname: Ozelius
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Risch
authors.forename: Susan B
authors.initials: SB
authors.lastname: Bressman
mesh_terms: D000328:Adult; D004421:Dystonia / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones / Q000235:genetics*; D009154:Mutation; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D010641:Phenotype
chemical_list: D018832:Molecular Chaperones; C108175:TOR1A protein, human