title: Human thioesterase superfamily member 2 (hTHEM2) is co-localized with beta-tubulin onto the microtubule.
abstract: Human thioesterase superfamily member 2 (hTHEM2) belongs to the hotdog-fold enzyme superfamily but its biological function remains unknown. Tissue specific expression in mouse showed that the encoding gene is highly expressed in the kidney, and moderately expressed in the liver, brain, large intestine, and small intestine. Small interference RNA silencing in cell line HCT116 shows that the hthem2 gene is essential for the cell sustained proliferation. Immunostaining and GFP-Tag experiments show that hTHEM2 is co-localized with microtubules.
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: Zhongjun
authors.initials: Z
authors.lastname: Cheng
authors.forename: Shilai
authors.initials: S
authors.lastname: Bao
authors.forename: Xiaoyue
authors.initials: X
authors.lastname: Shan
authors.forename: Hang
authors.initials: H
authors.lastname: Xu
authors.forename: Weimin
authors.initials: W
authors.lastname: Gong
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D008870:Microtubules / Q000378:metabolism*; D009928:Organ Specificity; D013869:Thiolester Hydrolases / Q000378:metabolism*; D014018:Tissue Distribution; D014404:Tubulin / Q000378:metabolism*
chemical_list: D014404:Tubulin; C514740:ACOT13 protein, human; D013869:Thiolester Hydrolases