title: Are penetrating aortic ulcers best treated using an endovascular approach?
abstract: BACKGROUND
  Optimal treatment for penetrating aortic ulcers has yet to be determined. Although open surgical repair is an effective therapeutic option, less invasive alternatives such as endoluminal grafting are emerging as a potential adjunct for the treatment of penetrating aortic ulcers isolated to the descending thoracic aorta. We reviewed our cumulative experience with thoracic endografting for penetrating aortic ulcers of the descending thoracic aorta.
  
  
  METHODS
  Between March 2003 and September 2005, 21 patients with penetrating aortic ulcers of the descending thoracic aorta were treated with Gore TAG thoracic endoluminal stent-grafts as part of a single-center investigational device exemption protocol.
  
  
  RESULTS
  Mean patient age was 73 +/- 12 years, and 7 (33%) of 21 were men and 14 (67%) were women. Patients presented with both acute (<14 days; 16/21, 76.2%) and chronic symptoms (5/21, 23.8%). The endoluminal stent-graft was successfully delivered in all 21 patients. No endoleaks were detected at 30-days postprocedurally or in follow-up (mean follow-up, 14 +/- 18 months). The 30-day mortality was 0%, and overall mortality was 4.8% (1/21), which was unrelated to the endovascular intervention.
  
  
  CONCLUSIONS
  Endovascular therapy for penetrating aortic ulcers of the descending thoracic aorta is safe and feasible. The number of patients diagnosed with penetrating aortic ulcers is expected to increase as improved imaging systems are becoming more commonplace. As a result, new and safer treatment paradigms will become even more important in the treatment of aortic diseases. Compared with historical surgical results, endovascular therapy for penetrating aortic ulcers of the descending thoracic aorta appears to have less operative mortality and is as equally effective as open surgical repair. Long-term surveillance and continued investigation are warranted.
authors.affiliation: Division of Cardiothoracic Surgery, Virginia Commonwealth University Medical Center/Medical College of Virginia, Richmond, Virginia, USA.
authors.forename: Derek R
authors.initials: DR
authors.lastname: Brinster
authors.forename: Grayson H
authors.initials: GH
authors.lastname: Wheatley
authors.forename: James
authors.initials: J
authors.lastname: Williams
authors.forename: Venkatesh G
authors.initials: VG
authors.lastname: Ramaiah
authors.forename: Edward B
authors.initials: EB
authors.lastname: Diethrich
authors.forename: Julio A
authors.initials: JA
authors.lastname: Rodriguez-Lopez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001018:Aortic Diseases / Q000150:complications / Q000601:surgery*; D050197:Atherosclerosis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents; D014456:Ulcer / Q000209:etiology / Q000601:surgery*