[Necrolytic migratory erythema in Waldmann's disease].
BACKGROUND
We report a case of necrolytic migratory erythema in a patient with Waldmann's disease.


METHODS
A 55-year-old male patient with a history of Waldmann's disease was hospitalized for a rash on the trunk and limbs comprising annular polycyclic lesions with peripheral scaling evocative of necrolytic migratory erythema. High-protein and fatty-acid-supplemented parenteral feeding led to rapid improvement of the patient's cutaneous lesions.


CONCLUSIONS
Waldmann's disease is characterized by intestinal lymphatic abnormalities leading to exudative intestinal disease causing protein loss in the bowel lumen and deficient fatty acid absorption. The pathogenesis of necrolytic migratory erythema is not fully understood. Increased serum glucagon does not appear to be the only mechanism involved. The occurrence of necrolytic migratory erythema in a patient with Waldmann's disease supports the current physiopathological hypothesis of the role of decreased plasma protein and amino acid levels in necrolytic migratory erythema.
Baricault
S
S
Clinique Dermatologique, CHU de Rouen, France.
Soubrane
J C
JC
Courville
P
P
Young
P
P
Joly
P
P
D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D004750:Enteral Nutrition; D004890:Erythema / Q000178:diet therapy / Q000209:etiology*; D005076:Exanthema / Q000209:etiology; D005227:Fatty Acids / Q000008:administration & dosage; D006801:Humans; D008201:Lymphangiectasis, Intestinal / Q000150:complications* / Q000178:diet therapy; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011504:Protein-Losing Enteropathies / Q000209:etiology
D004041:Dietary Fats; D004044:Dietary Proteins; D005227:Fatty Acids