Report of novel chromosomal abnormalities in a series of 130 chronic lymphocytic leukemia patients studied by classic cytogenetic analysis.
One-hundred-and-thirty typical, unselected CLL cases were studied by conventional cytogenetic analysis. Seventy-three patients (56.2%) had normal karyotype ('normal sub-group'), while 57/130 patients (43.8%) had abnormal karyotype. Twenty-two of 57 patients (38.6%) carried more than one abnormality. Six novel chromosomal abnormalities were detected in five patients: (i) t(3;13)(q14;q34); (ii) t(Y;11)(q12;q23), del(13)(q12q14); (iii) dic(3;11)(p21;q23); (iv) t(3;5)(q29;q23); (v) t(3;22) (p21;q13); and (vi) t(1;13)(p12;q12). Three of five patients carrying novel translocations had progressive disease. The true biological and clinical significance of novel chromosomal abnormalities remains to be determined.
Athanasiadou
Anastasia
A
Hematology Department and BMT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece. stavstam@otenet.gr
Stamatopoulos
Kostas
K
Tsezou
Aspasia
A
Vadikolia
Chrysanthi
C
Asteriou
Olga
O
Fassas
Athanasios
A
Anagnostopoulos
Achilles
A
D000368:Aged; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis / Q000379:methods*; D003582:Cytogenetics / Q000379:methods*; D030541:Databases, Genetic; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic