Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic.
We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistance. MDR strains in Bangui may emerge preferentially from a single, MDR-prone family.
Nouvel
Laurent X
LX
Institut Pasteur, Paris, France.
Kassa-Kelembho
Eric
E
Dos Vultos
Tiago
T
Zandanga
Germain
G
Rauzier
Jean
J
Lafoz
Carmen
C
Martin
Carlos
C
Blazquez
Jesus
J
Talarmin
Antoine
A
Gicquel
Brigitte
B
D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002488:Central African Republic / Q000453:epidemiology; D004260:DNA Repair; D012321:DNA-Directed RNA Polymerases; D006801:Humans; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D009841:Oligonucleotides / Q000032:analysis; D020641:Polymorphism, Single Nucleotide; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology*
D000995:Antitubercular Agents; D001426:Bacterial Proteins; D009841:Oligonucleotides; C505805:rpoB protein, Mycobacterium tuberculosis; D012321:DNA-Directed RNA Polymerases