title: Hypolipemic effect of water extracts of Picrorrhiza kurroa in high fat diet treated mouse.
abstract: A hypolipemic effect of the water extract of Picrorrhiza kurroa (PR) was observed in a high fat diet feeding hyperlipemic mouse at doses of 50, 100 and 200 mg/kg, orally, once a day for 12 weeks. Liver weight, serum aspartate transferase (AST), alanine transferase (ALT), low density lipoprotein (LDL), triglyceride and total cholesterol levels were significantly reduced by the treatment. On the contrary, serum HDL level seems not affected by P. kurroa water extract.
authors.affiliation: Department of Herbal Biotechnology, Daegu Haany University, Gyeongsan, 712-715, Republic of Korea.
authors.forename: Hyeung Sik
authors.initials: HS
authors.lastname: Lee
authors.forename: Choon Bo
authors.initials: CB
authors.lastname: Yoo
authors.forename: Sae Kwang
authors.initials: SK
authors.lastname: Ku
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009765:Obesity / Q000188:drug therapy*; D008517:Phytotherapy; D032261:Picrorhiza; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D018547:Plant Stems; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase