Lipid profile during pregnancy in HIV-infected women.
OBJECTIVE
We investigated the evolution of serum lipid levels in HIV-infected pregnant women and the potential effect of antiretroviral treatment during pregnancy using data from a national surveillance study.


METHODS
Fasting lipid measurements collected during routine care in pregnancy were used, analyzing longitudinal changes and differences in lipid values at each trimester by protease inhibitors (PIs) and stavudine use. Multivariate analyses were used to control for simultaneous factors potentially leading to hyperlipidemia. Study population included 248 women.


RESULTS
Lipid values increased progressively and significantly during pregnancy: mean increases between the first and third trimesters were 141.6 mg/dL for triglycerides (p < .001), 60.8 mg/dL for total cholesterol (p < .001), 13.7 mg/dL for HDL cholesterol (p < .001), and 17.8 mg/dL for LDL cholesterol (p = .001). At all trimesters, women on PIs had significantly higher triglyceride values compared to women not on PIs. The effect of PIs on cholesterol levels was less consistent. Stavudine showed a dyslipidemic effect at first trimester only. Multivariate analyses confirmed these observations and suggested a potential role of other cofactors in the development of hyperlipidemia during pregnancy.


CONCLUSIONS
The changes observed point to the need to further explore the causes and the clinical correlates of hyperlipidemia during pregnancy in women with HIV.
Floridia
M
M
Department of Drug Research and Evaluation, Istituto Superiore di Sanità, Rome. floridia@iss.it
Tamburrini
E
E
Ravizza
M
M
Tibaldi
C
C
Ravagni Probizer
M F
MF
Anzidei
G
G
Sansone
M
M
Mori
F
F
Rubino
E
E
Meli
M
M
Dalzero
S
S
Guaraldi
G
G
D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D007558:Italy; D050356:Lipid Metabolism / Q000187:drug effects; D016015:Logistic Models; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood*; D011264:Pregnancy Trimesters / Q000097:blood; D018119:Stavudine / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017320:HIV Protease Inhibitors; D014280:Triglycerides; D018119:Stavudine