title: Sebaceous hyperplasia and skin cancer in patients undergoing renal transplant.
abstract: BACKGROUND
  One previous study has shown a higher prevalence of sebaceous hyperplasia (SH) in patients with heart transplant on immunosuppressive drugs as compared with sex-matched control patients.
  
  
  OBJECTIVE
  We set out to compare the prevalence of SH in a cohort of patients undergoing renal transplant with age- and sex-matched control patients and to find any association with nonmelanoma skin cancer (NMSC) in these patients.
  
  
  METHODS
  In all, 117 patients with renal transplant and 117 age- and sex-matched control patients were screened for the prevalence of SH and NMSC.
  
  
  RESULTS
  We found that 29.9% of our patients with renal transplant had SH; 16 of 35 (45.7%) of these patients had a history of NMSC as compared with 6 of 82 (7.3%) patients without SH (P < .001, odds ratio 10.7). In the age- and sex-matched control group, a total of 28 patients (23.9%) had one or more lesions of SH.
  
  
  CONCLUSIONS
  This study is small and will require confirmation with larger cohort studies.
  
  
  CONCLUSIONS
  In our cohort of patients with renal transplant we found a strong association of NMSC with SH. This association remained significant after correction of factors such as age, sex, skin type, and duration of transplant.
authors.affiliation: Department of Dermatology, School of Medicine, University Hospital of North Staffordshire, Staffordshire, United Kingdom.
authors.forename: Asad
authors.initials: A
authors.lastname: Salim
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Reece
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Smith
authors.forename: Denise
authors.initials: D
authors.lastname: Harrison
authors.forename: Helen M
authors.initials: HM
authors.lastname: Ramsay
authors.forename: Paul N
authors.initials: PN
authors.lastname: Harden
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Fryer
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006965:Hyperplasia; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012627:Sebaceous Glands / Q000473:pathology*; D012871:Skin Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology*; D006113:United Kingdom / Q000453:epidemiology