title: Aortic root dysfunctioning and its effect on left ventricular function in Ross procedure patients assessed with magnetic resonance imaging.
abstract: BACKGROUND
  This study evaluated the diameters and distensibility of the aortic root as well as the degree of aortic regurgitation (AR) and its effect on left ventricular (LV) function in patients 8.2 +/- 3.1 years after they underwent the Ross procedure, with a comparison of these parameters between patients and matched healthy subjects.
  
  
  METHODS
  Eighteen Ross procedure patients (16 male patients, age [mean +/- SD] 19.2 +/- 3.8 years) and 18 matched healthy subjects (16 male patients, age [mean +/- SD] 19.7 +/- 4.2 years) underwent magnetic resonance imaging. Measurements for diameters (at 4 levels) and the distensibility of the aortic root were performed using a steady-state free precession sequence. Aortic flow was assessed with a velocity-encoded phase-contrast sequence. Left ventricular systolic function was assessed with a gradient-echo sequence in the short-axis plane. Comparison of parameters was performed using the Mann-Whitney U test. Correlations between diameters, distensibility, AR fraction, and LV systolic function were expressed with Spearman rank correlation coefficients. Linear regression analysis was used to identify predictors of LV systolic dysfunction.
  
  
  RESULTS
  Aortic root diameters were increased in Ross procedure patients as compared with healthy subjects (mean difference 6.3-11.6 mm, P < or = .02 at all 4 levels). Distensibility of the aortic root was lower in patients (1.9 +/- 1.1 vs 7.8 +/- 3.3 mm Hg(-1), P < .01). An AR fraction > 5% was present in 14 of the 18 patients (mean AR fraction 8% +/- 5% vs 1% +/- 1%, P < .01). Left ventricular ejection fraction was lower in patients (50% +/- 6% vs 57% +/- 6%, P < .01). Dilatation, decreased distensibility, and AR fraction were correlated with impaired LV systolic function (P < .05 for all). The AR fraction predicted impaired LV systolic function (P < .01).
  
  
  CONCLUSIONS
  Magnetic resonance imaging shows dilatation and decreased distensibility of the aortic root, AR, and consequent impaired LV systolic function in patients after the Ross procedure.
authors.affiliation: Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Heynric B
authors.initials: HB
authors.lastname: Grotenhuis
authors.forename: Jos J M
authors.initials: JJ
authors.lastname: Westenberg
authors.forename: Joost
authors.initials: J
authors.lastname: Doornbos
authors.forename: Lucia J M
authors.initials: LJ
authors.lastname: Kroft
authors.forename: Paul H
authors.initials: PH
authors.lastname: Schoof
authors.forename: Mark G
authors.initials: MG
authors.lastname: Hazekamp
authors.forename: Hubert W
authors.initials: HW
authors.lastname: Vliegen
authors.forename: Jaap
authors.initials: J
authors.lastname: Ottenkamp
authors.forename: Albert
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000293:Adolescent; D001011:Aorta / Q000503:physiopathology*; D001018:Aortic Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D001021:Aortic Valve / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002648:Child; D004108:Dilatation, Pathologic; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D011664:Pulmonary Valve / Q000601:surgery; D012039:Regional Blood Flow; D014664:Vasodilation; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology