title: Biomimetic calcium phosphate composite coating of dental implants.
abstract: OBJECTIVE
  The aim of the present study was to test the hypothesis that calcium phosphate coating of titanium screw-type implants enhances peri-implant bone formation in the jaw.
  
  
  METHODS
  Ten adult female foxhounds received experimental titanium screw-type implants in the mandible 3 months after removal of all premolar teeth. Four types of implants were evaluated in each animal: implants with machined titanium surface (the control group), implants coated with collagen I (the collagen-only group), implants with a composite coating of calcium phosphate and mineralized collagen I (the composite group), and implants with calcium phosphate (hydroxyapatite [HA]) coating (the HA-only group). Peri-implant bone regeneration was assessed histomorphometrically after 1 and 3 months in 5 dogs each by measuring bone-implant contact (BIC) and the volume density of the newly formed peri-implant bone (BVD).
  
  
  RESULTS
  After 1 month, BIC was significantly enhanced only in the group of implants with composite coating of calcium phosphate and mineralized collagen (P = .038). Volume density of the newly formed peri-implant bone was significantly higher in all coated implants after 1 month. No significant difference from baseline was found in BIC for the collagen-only and HA-only groups, but BVD was significantly higher in implants with composite coating (P = .041). After 3 months, BIC and BVD were significantly higher in all coated implants than in the controls with machined surfaces.
  
  
  CONCLUSIONS
  It was concluded that composite coating of dental screw-type implant surfaces using calcium phosphate and collagen can enhance BIC and peri-implant bone formation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, George-Augusta-University, Göttingen, Germany. schliephake.henning@med.uni-goettingen.de
authors.forename: Henning
authors.initials: H
authors.lastname: Schliephake
authors.forename: Dieter
authors.initials: D
authors.lastname: Scharnweber
authors.forename: Sophie
authors.initials: S
authors.lastname: Roesseler
authors.forename: Michel
authors.initials: M
authors.lastname: Dard
authors.forename: Andreas
authors.initials: A
authors.lastname: Sewing
authors.forename: Arash
authors.initials: A
authors.lastname: Aref
mesh_terms: D000818:Animals; D040761:Biomimetic Materials; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D024042:Collagen Type I; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D017886:Durapatite; D005260:Female; D016348:Osseointegration; D013499:Surface Properties; D014025:Titanium
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D024042:Collagen Type I; D015921:Dental Implants; D017886:Durapatite; D014025:Titanium