Carnitine-esters from the mushroom Suillus laricinus.
Carnitine-esters (1-8) including, a compound (R)-3-hydroxybutanoyl-(R)-carnitine (5), were isolated from the mushroom Suillus laricinus. Their structures were determined by spectroscopic analyses and by total synthesis. One of these, (R)-3-hydroxy-2-methylpropanoyl-(R)-carnitine (4), promoted hyaluronan-degradation by human skin fibroblasts.
Kawagishi
Hirokazu
H
Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan. achkawa@agr.shizuoka.ac.jp
Murakami
Hiroaki
H
Sakai
Shingo
S
Inoue
Shintaro
S
D001487:Basidiomycota / Q000737:chemistry*; D002331:Carnitine / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D004952:Esters; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment
D004952:Esters; D006820:Hyaluronic Acid; D002331:Carnitine