Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I.
Retinoic acid-inducible gene-I (RIG-I) is considered to play a role in innate immunity against virus infections. We showed by immunohistochemical study that RIG-I expression is upregulated in vivo in hepatic Kupffer cells and in splenic reticular cells of mice infected with Listeria monocytogenes. Both heat-killed L. monocytogenes and live L. monocytogenes induced the expression of RIG-I in cultured RAW264.7 murine macrophage-like cells in vitro. RIG-I may also be involved in innate immunity against Listeria infection.
Imaizumi
Tadaatsu
T
Vascular Biology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan. timaizum@cc.hirosaki-u.ac.jp
Sashinami
Hiroshi
H
Mori
Fumiaki
F
Matsumiya
Tomoh
T
Yoshida
Hidemi
H
Nakane
Akio
A
Wakabayashi
Koichi
K
Oyama
Chikara
C
Satoh
Kei
K
D000818:Animals; D002460:Cell Line; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D007113:Immunity, Innate; D007150:Immunohistochemistry; D008089:Listeria monocytogenes / Q000472:pathogenicity*; D008088:Listeriosis / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000032:analysis
D012333:RNA, Messenger; C503356:Ddx58 protein, mouse; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases