title: Inhibition activities of Colchicum luteum baker on lipoxygenase and other enzymes.
abstract: In vitro enzymes inhibition activities of the crude methanolic extract and various fractions of Colchicum luteum Baker (Liliaceae) including chloroform, ethyl acetate, n-butanol and aqueous were carried out against actylcholinesterase, butyrylcholinesterase, lipoxygenase and urease enzymes. A significant enzyme inhibition activity (89%) is shown by the crude methanolic extract and its fractions against lipoxygenase, while low to significant activity (32-75%) was evident against butyrylcholinesterase. The crude methanolic extract and its various fractions demonstrated low activity (29-61%) against acetylcholinesterase and no activity against urease.
authors.affiliation: Department of Pharmacy, University of Peshawar, NWFP, Pakistan. bashirdr2001@yahoo.com
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmad
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.forename: Shumaila
authors.initials: S
authors.lastname: Bashir
authors.forename: M
authors.initials: M
authors.lastname: Nisar
authors.forename: M
authors.initials: M
authors.lastname: Hassan
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry; D002091:Butyrylcholinesterase / Q000737:chemistry; D003079:Colchicum / Q000378:metabolism*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016166:Free Radical Scavengers; D008084:Lipoxygenase / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D014510:Urease / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D014510:Urease; D000432:Methanol