[Chemical constituents from Viscum nudum and their accelerating PC12 cell differentiation].
OBJECTIVE
To investigate chemical constituents of the stem of Viscum nudum and their bioacyivity.


METHODS
The major chemical constituents were isolated from the AcOEt-solved part of ethanol-extract of the plant by column chromatography and the active screening test in vitro were taken out for looking for compounds to acccelerate PC12 cell differentiation.


RESULTS
5 compounds were identified as eriodictyol (1), 5, 7-dihydroxy-3', 4'-dimethoxy flavanone (2), oleanolic (3), 5, 7-dihydroxychromone (4) and homeriodictyol (5) by spectral evidences, in which homeriodictyol (5) had acceleration differentiation to PC12 cell.


CONCLUSIONS
All compounds were obtained from this plant for the first time, and bioactive constituent was observed in the AcOEt-solved part.
Zhu
Hai-Yan
HY
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
Yu
Zheng-Wen
ZW
Yang
Xiao-Sheng
XS
Hao
Xiao-Jiang
XJ
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016716:PC12 Cells / Q000166:cytology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D028181:Viscum / Q000737:chemistry*
D002867:Chromones; D044950:Flavanones; D047309:Flavones; C080094:5,7-dihydroxychromone; D009828:Oleanolic Acid; C503231:homoeriodictyol; C007619:eriodictyol