title: Strong ion difference excess and corrected strong ion difference model incorporating the variations in apparent dissociation constant for human blood plasma electro-neutrality equilibria.
abstract: We introduce computed value of the corrected Strong Ion Difference (SID) by including the large variability of the apparent dissociation constant pK' in non-logarithmic form on SID in Henderson-Hasselbach bicarbonate ion aqueous equilibria thereby resulting in a significant correction of up to 27% in SID. We further introduce a new concept of Strong Ion Difference Excess (SIDE) as the change in SID from the reference value at pH = 7.4, pCO2 = 5.33 Kpa (or 40 torr). The SIDE is a particularly useful quick measure when one can rule out the effects of hemoglobin, weak proteins and unidentified components for human blood plasma.
authors.affiliation: ALT.CMOS, Sunnyvale, California CA 94087, USA. marty@alt-cmos.com
authors.forename: Amar P S
authors.initials: AP
authors.lastname: Rana
authors.forename: Sam Pal
authors.initials: SP
authors.lastname: Rana
authors.forename: Jay Pal
authors.initials: JP
authors.lastname: Rana
authors.forename: Sumarjeet
authors.initials: S
authors.lastname: Singh
mesh_terms: D000136:Acid-Base Equilibrium; D001639:Bicarbonates / Q000097:blood*; D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D008954:Models, Biological
chemical_list: D001639:Bicarbonates; D002245:Carbon Dioxide