title: Endoscopic submucosal dissection for early gastric cancers and large flat adenomas.
abstract: OBJECTIVE
  Endoscopic submucosal dissection (ESD) is a new diagnostic and treatment technique for early gastric cancer (EGC). The present study aims to identify the technical feasibility, operation time, and complications associated with ESD.
  
  
  METHODS
  We reviewed the patients who underwent ESD for EGCs at Maebashi Red Cross Hospital.
  
  
  RESULTS
  There were 160 patients with 171 EGCs treated by ESD. The mean age was 71.4 +/- 8.9 years (median 72). The rate for one-piece resection with tumor-free margins was 94.2 % (161/171), and was 93.2 % (82/88) for large lesions (> 20 mm) and 92.1 % (35/38) for ulcerative lesions. The median operation time was 80 min (range 10-600 min). Evidence of immediate bleeding was found in 2.9 % (5/171), delayed bleeding was seen in 7.6 % (13/171), and perforation was observed in 3.5 % (6/171) of the lesions. All patients with complications, including perforation, were successfully treated endoscopically. There were no local or distant metastases in the lesions which met our indication criteria for ESD.
  
  
  CONCLUSIONS
  The present study shows the technical feasibility of ESD, which provides the capability of one-piece resection even in large and ulcerative lesions.
authors.affiliation: Gastroenterology Center, Maebashi Red Cross Hospital, Maebashi, Gunma, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Onozato
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
authors.forename: H
authors.initials: H
authors.lastname: Iizuka
authors.forename: N
authors.initials: N
authors.lastname: Sohara
authors.forename: S
authors.initials: S
authors.lastname: Kakizaki
authors.forename: S
authors.initials: S
authors.lastname: Okamura
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D005753:Gastric Mucosa / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome