title: Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord blood.
abstract: Fetal exposure to phthalates may be associated with adverse reproductive effects, including cryptorchidism and decreased semen quality. Information about human placental transfer is needed to qualify the hypotheses. A dual recirculating placenta perfusion system to monitor concentrations of eight phthalate monoesters in fetal and maternal perfusates was established. In addition to perfusate background measures of phthalate monoesters, the concentrations in umbilical cord plasma and placenta tissue were measured. Monomethyl phthalate (mMP), monoethyl phthalate (mEP), monobutyl phthalate (mBP), and mono (2-ethyl-hexyl) phthalate (mEHP) were detected in both maternal and fetal perfusate, demonstrating a release of compounds from tissue or blood to perfusates. The distribution of compounds between perfusate, umbilical cord plasma, and tissue was in accordance with the physical-chemical properties of the compounds. Results from the present study of compounds residing in the tissue are essential before studying human transplacental transfer, storage, and metabolism of selected phthalate monoesters.
authors.affiliation: Department of Occupational and Environmental Health, Institute of Public Health, University of Copenhagen, Denmark. t.d.mikkelsen@pubhealth.ku.dk
authors.forename: Tina
authors.initials: T
authors.lastname: Mose
authors.forename: Gerda K
authors.initials: GK
authors.lastname: Mortensen
authors.forename: Morten
authors.initials: M
authors.lastname: Hedegaard
authors.forename: Lisbeth E
authors.initials: LE
authors.lastname: Knudsen
mesh_terms: D000328:Adult; D004785:Environmental Pollutants / Q000032:analysis / Q000493:pharmacokinetics*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000187:drug effects* / Q000502:physiology; D010477:Perfusion; D010795:Phthalic Acids / Q000032:analysis / Q000493:pharmacokinetics*; D010920:Placenta / Q000098:blood supply / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D004785:Environmental Pollutants; D010795:Phthalic Acids