title: Papillary cystadenocarcinoma: report of a case of high-grade histopathologic malignancy.
abstract: Papillary cystadenocarcinoma is an extremely rare malignant tumor of the salivary gland which is cytologically considered to be of low-grade malignancy, showing an indolent biological behavior. Histologically, the tumor is characterized by cysts and papillary endocystic projections. This tumor most commonly arises in the major salivary glands, mainly the parotid gland. We report here a case of papillary cystadenocarcinoma originating from the minor salivary gland, which showed marked growth over a short period of time. Histologically, the tumor was characterized by intense cellular and nuclear pleomorphism and numerous mitotic figures. These findings indicate a tumor of high-grade malignancy.
authors.affiliation: Laboratory of Oral Pathology, Dentistry School, Federal University of Rio Grande do Norte, Natal, Brazil. Av. Senador Salgado Filho, 1787 CEP-59056-000 Natal, RN, Brazil.
authors.forename: Roberta Barroso
authors.initials: RB
authors.lastname: Cavalcante
authors.forename: Márcia Cristina
authors.initials: MC
authors.lastname: da Costa Miguel
authors.forename: Abrahão Cavalcante
authors.initials: AC
authors.lastname: Souza Carvalho
authors.forename: Renato Luiz
authors.initials: RL
authors.lastname: Maia Nogueira
authors.forename: Lélia
authors.initials: L
authors.lastname: Batista de Souza
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018283:Cystadenocarcinoma, Papillary / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008938:Mitosis; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*; D013954:Thyroglobulin / Q000032:analysis; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D013954:Thyroglobulin