Surface-enhanced Raman scattering-based nanoprobe for high-resolution, non-scanning chemical imaging.
This work describes the development and demonstration of a non-scanning chemical imaging probe, capable of obtaining surface-enhanced Raman scattering (SERS) images of samples with which it is in direct contact. The SERS imaging arrays (i.e., nanoprobes) are used in a signal collection mode to obtain images by measuring as many as 30 000 individual sub-diffraction-limited locations on a sample's surface simultaneously. These SERS probes are fabricated from coherent fiber-optic imaging bundles, allowing for the formation of a highly ordered roughened metal surface, capable of providing uniform SERS enhancement (<2.0% relative standard deviation) across the entire imaging surface. These optimized SERS nanoprobes have potential application to a wide range of research fields from materials science to cellular biology.
Hankus
Mikella E
ME
Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA.
Li
Honggang
H
Gibson
Gregory J
GJ
Cullum
Brian M
BM
D036103:Nanotechnology; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*; D013499:Surface Properties