title: Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease.
abstract: Since many nuclear proteins are ectopically localized in the cytoplasm in the vulnerable neurons in Alzheimer disease (AD), we speculated that there is failure of the cytoplasmic-nuclear transport machinery in AD. In support of this notion, we found that importin alpha1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano bodies in vulnerable hippocampal neurons in AD. These data suggest a hindrance in importin-mediated cytoplasmic-nuclear transport in AD.
authors.affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. hyoung-gon.lee@case.edu
authors.forename: Hyoung-gon
authors.initials: HG
authors.lastname: Lee
authors.forename: Masumi
authors.initials: M
authors.lastname: Ueda
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yoneda
authors.forename: George
authors.initials: G
authors.lastname: Perry
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000199:Actins / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D016874:Neurofibrillary Tangles / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D020774:Pick Disease of the Brain / Q000378:metabolism / Q000473:pathology; D028901:alpha Karyopherins / Q000378:metabolism*
chemical_list: D000199:Actins; D028901:alpha Karyopherins; C087978:karyopherin alpha 2