title: Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs.
abstract: OBJECTIVE
  In the present study, the contractile response to norepinephrine (NE) and relaxing response to histamine and leukotriene D(4) (LTD(4)) were compared among the nasal mucosae of septa (S) and lateral (L) and medial turbinates (M) isolated from naive male Hartley guinea pigs.
  
  
  METHODS
  The isometrical tension of the isolated nasal mucosae of the above regions was measured at a resting tension of 0.5 g by using a standard organ-bath technique.
  
  
  RESULTS
  In each mucosal strip, NE induced a contraction in a concentration-dependent manner. A significant difference in efficacy (maximal response) of NE was found (L>M>S). In mucosal strips precontracted with NE (3x10(-5)M), both histamine and LTD(4) induced relaxing responses. The efficacy of histamine in S was significantly greater than those in L and M. The potency order of LTD(4) was L>M>S; a significant difference was observed between L and S.
  
  
  CONCLUSIONS
  In conclusion, the present study demonstrated a distinct regional difference in the response to contractile and relaxant agonists of isolated nasal mucosae of guinea pigs.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. chiba@hoshi.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Chiba
authors.forename: Kensuke
authors.initials: K
authors.lastname: Matsuo
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Sakai
authors.forename: Kazuho
authors.initials: K
authors.lastname: Abe
authors.forename: Miwa
authors.initials: M
authors.lastname: Misawa
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D017998:Leukotriene D4 / Q000494:pharmacology*; D008297:Male; D009297:Nasal Mucosa / Q000098:blood supply*; D009300:Nasal Septum / Q000098:blood supply; D009638:Norepinephrine / Q000494:pharmacology*; D014420:Turbinates / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D017998:Leukotriene D4; D006632:Histamine; D009638:Norepinephrine