title: Penetration of atazanavir in seminal plasma of men infected with human immunodeficiency virus type 1.
abstract: In this exploratory study, the human immunodeficiency virus (HIV) protease inhibitor atazanavir was detected in seminal plasma in 15 out of 15 HIV-infected men taking an atazanavir-containing regimen. However, this penetration was limited and variable, and the median seminal/blood plasma ratio was only 0.1.
authors.affiliation: Academic Medical Centre, Obstetrics and Gynecology, H4-205, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands. e.vanleeuwen@amc.uva.nl
authors.forename: E
authors.initials: E
authors.lastname: van Leeuwen
authors.forename: R
authors.initials: R
authors.lastname: Ter Heine
authors.forename: F
authors.initials: F
authors.lastname: van der Veen
authors.forename: S
authors.initials: S
authors.lastname: Repping
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: J M
authors.initials: JM
authors.lastname: Prins
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D000069446:Atazanavir Sulfate; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011725:Pyridines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012367:RNA, Viral / Q000097:blood; D012661:Semen / Q000378:metabolism*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D009842:Oligopeptides; D011725:Pyridines; D012367:RNA, Viral; D000069446:Atazanavir Sulfate