title: Three-dimensional analysis of shear wave propagation observed by in vivo magnetic resonance elastography of the brain.
abstract: Dynamic magnetic resonance elastography (MRE) is a non-invasive method for the quantitative determination of the mechanical properties of soft tissues in vivo. In MRE, shear waves are generated in the tissue and visualized using phase-sensitive MR imaging methods. The resulting two-dimensional (2-D) wave images can reveal in-plane elastic properties when possible geometrical biases of the wave patterns are taken into account. In this study, 3-D MRE experiments of in vivo human brain are analyzed to gain knowledge about the direction of wave propagation and to deduce in-plane elastic properties. The direction of wave propagation was determined using a new algorithm which identifies minimal wave velocities along rays from the surface into the brain. It was possible to quantify biases of the elastic parameters due to projections onto coronal, sagittal and transversal image planes in 2-D MRE. It was found that the in-plane shear modulus is increasingly overestimated when the image slice is displaced from narrow slabs of 2-5cm through the center of the brain. The mean shear modulus of the brain was deduced from 4-D wave data with about 3.5kPa. Using the proposed slice positions in 2-D MRE, this shear modulus can be reproduced with an acceptable error within a fraction of the full 3-D examination time.
authors.affiliation: Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany. uwe.hamhaber@charite.de
authors.forename: U
authors.initials: U
authors.lastname: Hamhaber
authors.forename: I
authors.initials: I
authors.lastname: Sack
authors.forename: S
authors.initials: S
authors.lastname: Papazoglou
authors.forename: J
authors.initials: J
authors.lastname: Rump
authors.forename: D
authors.initials: D
authors.lastname: Klatt
authors.forename: J
authors.initials: J
authors.lastname: Braun
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D004548:Elasticity; D006801:Humans; D019047:Phantoms, Imaging; D014783:Viscosity