The short-term administration of Ketoprofen does not decrease the effect of Pleurodesis induced by talc or Doxycycline in rabbits.
OBJECTIVE
To determine whether the concomitant administration of ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) has any effect on the pleurodesis induced by talc or doxycycline in rabbits.


METHODS
Four groups of seven New Zealand rabbits were assigned to receive the following treatments: 400mg/kg of talc intrapleurally only (group 1), 400mg/kg of talc plus 1mg/kg of ketoprofen intramuscularly (group 2), 10mg/kg of doxycycline intrapleurally only (group 3) and 10mg/kg of doxycycline plus 1mg/kg of ketoprofen intramuscularly (group 4). Intramuscular administration of ketoprofen began 4h before the intrapleural administration of the sclerosing agents, followed by twice daily administrations for 1 week. Pleural fluid was collected 24, 48 and 72h after intrapleural injections. Pleurodesis was evaluated macroscopically and microscopically after 14 days.


RESULTS
The concomitant use of ketoprofen at 1mg/kg does not decrease the WBC, LDH, and protein in pleural fluid at 24h following intrapleural injection of talc or doxycycline. There were no significant differences in the macroscopic pleurodesis scores, the degree of microscopic pleural fibrosis, the thickness of the pleura or the percent of the pleura occupied with angiogenesis.


CONCLUSIONS
The study shows that the short-term systemic administration of NSAIDs does not affect the efficacy of pleurodesis induced by talc or doxycycline in rabbits.
Liao
Huai
H
Department of Pulmonary Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China. liaohuai1208@hotmail.com
Guo
Yubiao
Y
Jun Na
Moon
M
Lane
Kirk B
KB
Light
Richard W
RW
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004318:Doxycycline / Q000008:administration & dosage*; D005355:Fibrosis; D007660:Ketoprofen / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D010994:Pleura / Q000098:blood supply / Q000473:pathology; D010996:Pleural Effusion / Q000517:prevention & control; D018700:Pleurodesis / Q000379:methods*; D011817:Rabbits; D013627:Talc / Q000008:administration & dosage*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013627:Talc; D007660:Ketoprofen; D004318:Doxycycline