title: Effects of cevimeline on salivation and thirst in conscious rats.
abstract: OBJECTIVE
  Intraperitoneal injection of a sialogogue, pilocarpine, at high concentrations induces salivation via peripheral pathways and thirst sensation via central pathways. In this study, we report that the effects of another sialagogue, cevimeline, on salivation and water intake in conscious rats differ from those of pilocarpine.
  
  
  METHODS
  We investigated that effects of peripherally and centrally injected cevimeline on parotid saliva flow rate and water intake in conscious rats. The results were compared with those of pilocarpine.
  
  
  RESULTS
  The intraperitoneal injection of cevimeline induced salivation from the parotid gland, but not water intake. In contrast, the intracerebroventricular injection of cevimeline induced water intake without salivation. The concentration of cevimeline needed to induce salivation by intraperitoneal injection was several 10 times that of pilocarpine, but that needed to induce water intake by intracerebroventricular injection was over a 1000 times greater.
  
  
  CONCLUSIONS
  The finding that intraperitoneally injected cevimeline induces salivation without inducing water intake, suggests that the effects on the thirst center in the brain are weaker than those of pilocarpine.
authors.affiliation: Department of Biosciences, Kyushu Dental College, 2-6-1 Manazuru, Fukuoka 803-8580, Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Sato
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ono
authors.forename: Kensuke
authors.initials: K
authors.lastname: Haga
authors.forename: Makoto
authors.initials: M
authors.lastname: Yokota
authors.forename: Kiyotoshi
authors.initials: K
authors.lastname: Inenaga
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004334:Drug Administration Schedule; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D018721:Muscarinic Agonists / Q000008:administration & dosage*; D010306:Parotid Gland / Q000187:drug effects / Q000502:physiology; D011812:Quinuclidines / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012472:Salivation / Q000187:drug effects*; D013876:Thiophenes / Q000008:administration & dosage*; D013894:Thirst / Q000187:drug effects*
chemical_list: D018721:Muscarinic Agonists; D011812:Quinuclidines; D013876:Thiophenes; C059240:cevimeline