5'-methylaristeromycin and related derivatives.
The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytotoxicity caused ostensibly by the intracellular formation of its 5'-nucleotide derivatives. Aristeromycin derivatives that offered steric interference to this transformation at the C-5' center were sought. This paper describes the facile stereospecific synthesis, where necessary, of such C-5'-methylated aristeromycin derivatives.
Ye
Wei
W
Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849-5312, USA. schnest@auburn.edu
Schneller
Stewart W
SW
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D003517:Cyclopentanes / Q000737:chemistry; D015394:Molecular Structure
C521697:5'-methylaristeromycin; D000998:Antiviral Agents; D003517:Cyclopentanes; C030034:aristeromycin; D000241:Adenosine