title: [Study on effect of Tiaomaiyin injection on experimental arrhythmia].
abstract: OBJECTIVE
  To study the effect of Tiaomaiyin injection on the experimental arrhythmia for analyzing its underlying mechanism in the treatment of cardiovascular disease.
  
  
  METHODS
  Experimental animals anesthetized with 20% urethane (6 mL x kg(-1)) were evenly randomized into control group, positive control group, low-dose and high-dose Tiaomaiyin group. The rate of ventricular fibrillation (VF) chloroform-induced in mice, and the epoch of ventricular extrasystole (VE), ventricular tachycardia (VT),VF and cardiac arrest (CA), actonitine-induced in rats (1.0 microg x mL(-1) x min(-1)), and vabain-induced in guinea pigs (10 microg x mL(-1) x min(-1)), were detected respectively. The result loas converted into cumulative dosage of actonitine or vabain. In ischemia-reperfusion model in rats, the duration of arrhythmia and activity of superoxide dismutase (SOD) and malondialdehyde (MDA) were detected.
  
  
  RESULTS
  After venous injection of Tiaomaiyin, VF in mice was lower significantly (P < 0.01), VE, VT, VF in rats and VF in guinea pigs were lowered considerably (P <0.05). The duration of arrhythmia in ischemia-reperfusion model was reduced considerably (P < 0.05), and the activity of myocardial SOD was raised significantly (P <0.01).
  
  
  CONCLUSIONS
  Tiaomaiyin shows the reduction of experimental arrhythmia and protect effect to ischemia-reperfusion injury of the heart, which indicates that the effect mechanism may have the relationship with inhabition of lipid peroxidation and damnification of the free radical.
authors.affiliation: Beijing University of Chinese Medicine, China. Firstlihong@yahoo.com.cn
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Niu
authors.forename: Guo-zhang
authors.initials: GZ
authors.lastname: Li
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Shi
authors.forename: Zhi-zhen
authors.initials: ZZ
authors.lastname: Wei
authors.forename: Jun-ping
authors.initials: JP
authors.lastname: Xiao
authors.forename: Xiu-hua
authors.initials: XH
authors.lastname: Sun
authors.forename: Bing-qin
authors.initials: BQ
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Xue
authors.forename: Shi-fang
authors.initials: SF
authors.lastname: Xi
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004562:Electrocardiography; D006168:Guinea Pigs; D007267:Injections; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D017202:Myocardial Ischemia / Q000150:complications; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000889:Anti-Arrhythmia Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase