Antimutagenic characteristics of new diazacrown compounds with N-carboxyalkyl substitutes.
Two new benzodiaza-15-crown-5 compounds containing two N-hydroxycarbonylmethyl or N-hydroxycarbonylpropyl substitutes were synthesized. The first of these compounds exhibited more pronounced protective effects towards human cells according to criteria of primary DNA injury and cell survival after exposure to gamma-radiation and CdCl2; by antimutagenic activity this compound was comparable to garlic extract. The antimutagenic effect of these compounds was realized not through the antioxidant mechanism.
Zasukhina
G D
GD
Institute of General Genetics, Russian Academy of Sciences, Moscow. zasukhina@vigg.ru
Vasil'eva
I M
IM
Vedernikov
A I
AI
Gromov
S P
SP
Alfimov
M V
MV
D016587:Antimutagenic Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D019256:Cadmium Chloride / Q000494:pharmacology; D047248:Crown Compounds / Q000494:pharmacology*; D004249:DNA Damage; D005720:Gamma Rays; D006801:Humans
D016587:Antimutagenic Agents; D001372:Aza Compounds; D047248:Crown Compounds; D019256:Cadmium Chloride