title: Aortic root aneurysm due to donor cystic medial degeneration after heart-lung transplantation.
abstract: A patient presented with symptomatic aortic root enlargement 5 years after combined heart and double-lung transplantation for cystic fibrosis, requiring homograft aortic root replacement. Histologic examination of the resected aneurysm showed cystic medial degeneration with no evidence of infectious or atherosclerotic process. Surgical options and potential role of immunosuppressive therapy after homograft implantation are discussed.
authors.affiliation: Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
authors.forename: Lois U
authors.initials: LU
authors.lastname: Nwakanma
authors.forename: Luca A
authors.initials: LA
authors.lastname: Vricella
authors.forename: John V
authors.initials: JV
authors.lastname: Conte
authors.forename: Robert C
authors.initials: RC
authors.lastname: Robbins
mesh_terms: D000328:Adult; D001011:Aorta / Q000637:transplantation; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D001018:Aortic Diseases / Q000150:complications* / Q000601:surgery; D003550:Cystic Fibrosis / Q000601:surgery*; D005260:Female; D016041:Heart-Lung Transplantation / Q000009:adverse effects*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D014019:Tissue Donors; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous