Role of CEACAM1 as a regulator of T cells.
A major immunological attribute of inflammatory bowel disease (IBD) is the presence of unrestrained activation of T cells that produce a variety of inflammatory cytokines and other mediators. Gaining an understanding of T cell regulation is therefore of major importance to IBD. Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1) is a novel protein that has been recently recognized as being expressed by immune cells and T lymphocytes, in particular; this protein appears to function as a coinhibitory receptor after T cell activation. Ligation of CEACAM1 on T cells induces a signal cascade that leads inhibition of T cell cytokine production and IBD. CEACAM1 is thus a novel potential therapeutic target in the treatment of IBD.
Nagaishi
Takashi
T
Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 USA.
Iijima
Hideki
H
Nakajima
Atsushi
A
Chen
Daohong
D
Blumberg
Richard S
RS
D015703:Antigens, CD / Q000235:genetics / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000502:physiology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D015703:Antigens, CD; C069847:CD66 antigens; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules