Energy consumption for the formation of hemoglobin A1c: a reappraisal and implication on the poor-control diabetes mellitus patients.
Diabetes mellitus (DM) is a frequent disorder affecting individuals of all ages. Glycohemoglobin has a key role in the assessment of glycemic control in diabetic patients. Several studies have clearly shown that improved glycemic control is strongly associated with decreased development and/or progression of diabetic complications. The chemical reaction of glycosylation in formation of hemoglobin A(1c) (HbA(1c)) has been described for decades. Here, the author performed a reappraisal on the bonding energy based on quantum chemical analysis. The author calculated the bonding energy of the reaction and found that the reaction is a type of "energy-consuming reaction." In addition, the author gives further implication of the findings on the poor-control DM patients. The author hereby proposed that the nature of energy-consuming reaction in formation of hemoglobin A(1c) (HbA(1c)) is a main underlying for the energy loosing in poorly controlled DM patients. Gathering of the energy from the nearby cellular compartment during formation of HbA(1c) might be an important pathological process.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. wviroj@yahoo.com <wviroj@yahoo.com>
D003920:Diabetes Mellitus / Q000378:metabolism*; D004734:Energy Metabolism; D006442:Glycated Hemoglobin / Q000737:chemistry* / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans
D006442:Glycated Hemoglobin