Photodynamic therapy with verteporfin of choroidal malignancy from breast cancer.
OBJECTIVE
To evaluate the effectiveness of photodynamic therapy (PDT) with verteporfin for treating a submacular choroidal metastasis from breast cancer.


METHODS
Interventional case report.


METHODS
Multispot PDT irradiation of tumor surface was performed in a 45-year-old woman who had a choroidal metastasis from breast cancer in the right eye. The response of uveal metastasis to photodynamic action was investigated with the use of fluorescein angiography and optical coherence tomography (OCT).


RESULTS
Within four months after photosensitization, the exudative detachment of the macula was resolved, with improvement in the visual acuity following decrease in the tumor vascular permeability and absorption of subretinal fluid.


CONCLUSIONS
PDT can effectively destroy a malignant tissue and induce an antitumor activity. PDT as an adjunct to chemotherapy is a possible treatment and might be appropriate for patients who require ocular treatment only.
Isola
Vincenzo
V
Retina and Angiography Service, Department of Ophthalmology, Melegnano Hospital, Milan, Italy. isolavincenzo@aliceposta.it
Pece
Alfredo
A
Pierro
Luisa
L
D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D015409:Mastectomy, Radical; D008875:Middle Aged; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D012163:Retinal Detachment / Q000175:diagnosis / Q000188:drug therapy; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use; D041623:Tomography, Optical Coherence; D000077362:Verteporfin; D014792:Visual Acuity
D017319:Photosensitizing Agents; D011166:Porphyrins; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D000077362:Verteporfin