title: A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene.
abstract: Muir-Torre syndrome (MTS) is a rare cancer-predisposing syndrome that is autosomal dominantly inherited and characterized by the development of sebaceous skin lesions (adenomas, epitheliomas, basaliomas and carcinomas). These lesions are typically associated with tumors that belong to the spectrum of hereditary nonpolyposis colorectal cancer (HNPCC) (i.e., tumors of the colorectum, endometrium, stomach or ovary). Biliary malignancy in association with MTS has only rarely been reported. We report a case of Muir-Torre syndrome associated with intrahepatic cholangiocarcinoma, a location not previously described, and associated with a novel missense mutation of the MSH2 gene (c.2026T > C), predicted to disrupt the function of the gene.
authors.affiliation: Department of Pathology, Institut Universitaire de Pathologie, Lausanne University Hospital, Bugnon 25, CH-1011 Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Vernez
authors.forename: P
authors.initials: P
authors.lastname: Hutter
authors.forename: C
authors.initials: C
authors.lastname: Monnerat
authors.forename: N
authors.initials: N
authors.lastname: Halkic
authors.forename: O
authors.initials: O
authors.lastname: Gugerli
authors.forename: H
authors.initials: H
authors.lastname: Bouzourene
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000601:surgery; D000236:Adenoma / Q000235:genetics / Q000601:surgery; D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics / Q000556:secondary / Q000601:surgery; D002277:Carcinoma / Q000235:genetics / Q000601:surgery; D018281:Cholangiocarcinoma / Q000235:genetics* / Q000556:secondary* / Q000601:surgery; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000601:surgery; D004252:DNA Mutational Analysis; D015342:DNA Probes; D004268:DNA-Binding Proteins; D016889:Endometrial Neoplasms / Q000601:surgery; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000601:surgery; D053842:Microsatellite Instability; D051718:MutS Homolog 2 Protein / Q000172:deficiency*; D020125:Mutation, Missense; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000601:surgery; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000601:surgery; D011127:Polyps / Q000601:surgery; D011392:Proline / Q000235:genetics; D012626:Sebaceous Gland Neoplasms / Q000235:genetics / Q000601:surgery; D012694:Serine / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics* / Q000556:secondary / Q000601:surgery; D013577:Syndrome
chemical_list: D015342:DNA Probes; D004268:DNA-Binding Proteins; D012694:Serine; D011392:Proline; D051718:MutS Homolog 2 Protein