Bilateral perysilvian polymicrogyria in Chiari I malformation.
METHODS
We report on a 7-year-old girl with generalized epilepsy and mental retardation.


CONCLUSIONS
Neurologic examination was normal and only facial dysmorphic features, compatible with frontonasal dysplasia, were observed. However, magnetic resonance imaging (MRI) revealed Chiari I malformation together with bilateral opercular polymicrogyria. To our knowledge, this is the first report of the association of these developmental disorders. This condition raises questions regarding the ethiopathogenetic classification of Chiari spectrum and as to whether embryologic and genetic causes could be potentially interconnected.
Spalice
Alberto
A
Child Neurology Division, Department of Pediatrics, University La Sapienza, Viale Regina Elena, 324, 00161, Rome, Italy.
Parisi
Pasquale
P
Mastrangelo
Mario
M
De Luca
Francesca
F
Verrotti
Alberto
A
Iannetti
Paola
P
D001139:Arnold-Chiari Malformation / Q000473:pathology*; D002531:Cerebellum / Q000002:abnormalities*; D002540:Cerebral Cortex / Q000002:abnormalities*; D002648:Child; D004829:Epilepsy, Generalized / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008607:Intellectual Disability / Q000473:pathology; D008279:Magnetic Resonance Imaging