title: Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction.
abstract: For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.
authors.affiliation: Fachbereich Chemie, Universität Konstanz, Fach M 725, D-78457 Konstanz, Germany.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Figueroa-Perez
authors.forename: Andreas
authors.initials: A
authors.lastname: Stadelmaier
authors.forename: Susanne
authors.initials: S
authors.lastname: Deininger
authors.forename: Sonja von
authors.initials: Sv
authors.lastname: Aulock
authors.forename: Thomas
authors.initials: T
authors.lastname: Hartung
authors.forename: Richard R
authors.initials: RR
authors.lastname: Schmidt
mesh_terms: D016207:Cytokines / Q000096:biosynthesis*; D004187:Disaccharides / Q000737:chemistry; D005994:Glycerophosphates / Q000737:chemistry; D008070:Lipopolysaccharides / Q000138:chemical synthesis*; D013211:Staphylococcus aureus / Q000737:chemistry; D013329:Structure-Activity Relationship; D013682:Teichoic Acids / Q000138:chemical synthesis*
chemical_list: D016207:Cytokines; D004187:Disaccharides; D005994:Glycerophosphates; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid; C100052:gentiobiose