Recurrent immune thrombocytopenic purpura in children.
Recurrent immune thrombocytopenic purpura (ITP) is defined as the recurrence of ITP after at least 3 months of remission sustained without treatment. Among 340 children with ITP, 14 had recurrent ITP (4.1%). Ten were females. The initial course was acute in 8 patients and chronic in 6. The median time to recurrence was 33 months (range 4-120). Only 1 patient had a second recurrence. Twelve (86%) achieved complete (n = 10) or partial (n = 2) remission, two of them after splenectomy. One patient continued to require treatment at 10 months from recurrence. One child died of intracranial hemorrhage despite aggressive treatment including splenectomy and craniotomy.
Jayabose
Somasundaram
S
Department of Pediatrics, New York Medical College, Valhalla, New York, USA. s_jayabose@nymc.edu
Levendoglu-Tugal
Oya
O
Ozkaynak
Mehmet F
MF
Sandoval
Claudio
C
D000293:Adolescent; D000328:Adult; D002543:Cerebral Hemorrhage / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010976:Platelet Count; D011241:Prednisone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000453:epidemiology* / Q000601:surgery / Q000628:therapy; D012008:Recurrence; D012074:Remission Induction; D013156:Splenectomy
D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D011241:Prednisone; D008775:Methylprednisolone