Reactions of PtII diamine anticancer complexes with trypanothione and octreotide.
The products formed in reactions of the square-planar platinum(II) anticancer complexes, [Pt(en)Cl(2)] and [Pt(R,R-dach)Cl(2)] where en=ethylenediamine and dach=diaminocyclohexane, with trypanothione, a glutathione analogue found in some parasites, and octreotide, a synthetic analogue of the hormone somatostatin, have been investigated. Mononuclear and binuclear platinum adducts were formed in reactions of the cyclic disulfides in their oxidised and reduced forms, and were analysed by UV-visible spectroscopy and liquid chromatography-mass spectrometry (LC-MS). NMR and molecular modelling studies were carried out on the mononuclear adducts.
Munk
Vivienne P
VP
School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JJ, UK.
Fakih
Sarah
S
Socorro Murdoch
Piedad Del
PD
Sadler
Peter J
PJ
D000970:Antineoplastic Agents / Q000737:chemistry*; D002853:Chromatography, Liquid; D005978:Glutathione / Q000031:analogs & derivatives* / Q000737:chemistry; D013058:Mass Spectrometry; D015282:Octreotide / Q000737:chemistry*; D017671:Platinum Compounds / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013095:Spermidine / Q000031:analogs & derivatives* / Q000737:chemistry
D000970:Antineoplastic Agents; D017671:Platinum Compounds; C044809:trypanothione; D005978:Glutathione; D015282:Octreotide; D013095:Spermidine