Alterations of mitochondrial DNA in CEM cells selected for resistance toward ddC toxicity.
2 ',3 '-dideoxycytidine (ddC) is a nucleoside analog that has been shown to produce a delayed toxicity which may be due to the depletion of mitochondrial DNA (mtDNA). In order to gain further understanding of the events involved in mitochondrial toxicity, two different CEM cell lines were selected for resistance to the delayed ddC toxicity.
Bjerke
M
M
Mitochondrial Medicine Center, Karolinska Institutet, Stockholm, Sweden. mia.bjerke@ki.se
Franco
M
M
Johansson
M
M
Balzarini
J
J
Karlsson
A
A
D000963:Antimetabolites / Q000494:pharmacology / Q000633:toxicity*; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D004272:DNA, Mitochondrial / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D009705:Nucleosides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D013997:Time Factors; D016047:Zalcitabine / Q000494:pharmacology / Q000633:toxicity*
D000963:Antimetabolites; D004272:DNA, Mitochondrial; D009705:Nucleosides; D010710:Phosphates; D016047:Zalcitabine