title: Sympathetic sudomotor disturbance in early type 1 diabetes mellitus is linked to lipid peroxidation.
abstract: The present study was performed to determine whether increased lipid peroxidation, as assessed from malondialdehyde (MDA) excretion, is associated with deterioration in peripheral nerve function in early type 1 diabetes mellitus. These parameters were measured annually for 3 years in 36 patients who entered the study less than 2 years after the diagnosis of diabetes. Malondialdehyde excretion was 1.51 +/- 0.20 micromol/g creatinine in the controls, and 2.43 +/- 0.21, 2.39 +/- 0.22, and 1.93 +/- 0.21 micromol/g creatinine at the first, second, and third evaluations, respectively (P < .005). The increased MDA was seen only in the female participants. Malondialdehyde excretion was increased in those with high vs low hemoglobin Alc across all years (P < .05). Malondialdehyde excretion correlated negatively with sudomotor function below the waist. The mean sweat production from the 3 evaluations correlated with mean MDA excretion across all years in the proximal leg (r = -0.42, P < .005) and distal leg (r = -0.40, P < .01). Below the waist, sweating correlated with MDA (r = -0.40, P < .01) as did total sweat (r = -0.38, P < .01). The response amplitudes of the peroneal nerves correlated negatively with MDA excretion (for the mean values at the second 2 evaluations, P < .005, r = -0.45). Tests of sensory function correlated inconsistently with MDA excretion. In summary, lipid peroxidation, as assessed from malondialdehyde excretion, is associated with sudomotor dysfunction in early diabetes.
authors.affiliation: Department of Medicine, West Virginia University, Morgantown, WV 26506-9159, USA. rhoeldtke@hsc.wvu.edu
authors.forename: Robert D
authors.initials: RD
authors.lastname: Hoeldtke
authors.forename: Kimberly D
authors.initials: KD
authors.lastname: Bryner
authors.forename: Martin E
authors.initials: ME
authors.lastname: Hoeldtke
authors.forename: Ian
authors.initials: I
authors.lastname: Christie
authors.forename: Gary
authors.initials: G
authors.lastname: Ganser
authors.forename: Gerald
authors.initials: G
authors.lastname: Hobbs
authors.forename: Jack
authors.initials: J
authors.lastname: Riggs
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008137:Longitudinal Studies; D008297:Male; D008315:Malondialdehyde / Q000652:urine; D009431:Neural Conduction / Q000502:physiology; D009566:Nitrates / Q000097:blood; D009638:Norepinephrine / Q000652:urine; D017933:Peripheral Nervous System / Q000378:metabolism*; D012044:Regression Analysis; D012083:Renin / Q000652:urine; D013546:Sweating / Q000502:physiology*; D014642:Vanilmandelic Acid / Q000097:blood
chemical_list: D015237:Dinoprost; D006442:Glycated Hemoglobin; D008315:Malondialdehyde; D009566:Nitrates; D009638:Norepinephrine; D012083:Renin; D014642:Vanilmandelic Acid; C075750:8-epi-prostaglandin F2alpha