title: Effects of various media on the activity of NXL103 (formerly XRP 2868), a new oral streptogramin, against Haemophilus influenzae.
abstract: The activity of NXL103 against 108 strains of Haemophilus influenzae was tested using Haemophilus test media (HTM) obtained from various sources. With the exception of those obtained with stored HTM, MICs did not differ significantly, with MIC(50) and MIC(90) values of 0.5 and 0.5 to 1 microg/ml, respectively, in each medium.
authors.affiliation: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Pankuch
authors.forename: Dianne
authors.initials: D
authors.lastname: Hoellman
authors.forename: André
authors.initials: A
authors.lastname: Bryskier
authors.forename: John
authors.initials: J
authors.lastname: Lowther
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006193:Haemophilus influenzae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D025364:Streptogramin A / Q000493:pharmacokinetics / Q000494:pharmacology*; D025381:Streptogramin B / Q000493:pharmacokinetics / Q000494:pharmacology*; D025361:Streptogramins / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D004338:Drug Combinations; D025361:Streptogramins; C509060:flopristin, linopristin drug combination; D025381:Streptogramin B; D025364:Streptogramin A