Toxicology case of the month: Carbamazepine overdose.
A 29-year-old woman presents shortly after a massive overdose of carbamazepine controlled-release tablets. In anticipation of coma, she is electively intubated to safely enable gastrointestinal decontamination with nasogastric activated charcoal. She is admitted to the intensive care unit for ongoing supportive care, and further doses of activated charcoal are prescribed to enhance elimination of carbamazepine. Carbamazepine levels remain high and haemodialysis is carried out to further enhance elimination. Her coma resolves as levels fall, but clinical progress is complicated by anticholinergic delirium, ileus and bowel obstruction from charcoal concretions. She survives to medical discharge on day 12.
Soderstrom
J
J
Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Murray
L
L
Little
M
M
Daly
F F S
FF
D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D001315:Australia; D002220:Carbamazepine / Q000506:poisoning*; D002606:Charcoal / Q000627:therapeutic use; D003128:Coma / Q000628:therapy; D062787:Drug Overdose / Q000628:therapy; D004630:Emergencies; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008991:Monitoring, Physiologic; D006435:Renal Dialysis; D018570:Risk Assessment; D007507:Therapeutic Irrigation
D000927:Anticonvulsants; D002606:Charcoal; D002220:Carbamazepine