title: [Validity of intraoperative administration of dexmedetomidine in a patient with dermatomyositis-derived respiratory failure].
abstract: A 66-year-old female with dermatomyositis and severe respiratory failure from collagen lungs, dependent on domiciliary oxygen therapy, was scheduled for a mastectomy. Anesthesia was induced with dexmedetomidine (DEX) 6 microg x kg(-1) x h(-1) for 10 minutes and maintained at 0.7 microg x kg(-1) x h(-1), along with a target controlled infusion of propofol combined with epidural anesthesia. No narcotic or muscle relaxant was used. The airway was secured using a laryngeal mask airway and spontaneous breathing was preserved. The perioperative course was uneventful without any pulmonary complications. DEX has a certain analgesic property and a mild respiratory depressant effect. Therefore, it is considered useful as a concomitant anesthetic agent for perioperative management of patients with respiratory failure.
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima 734-8551.
authors.forename: Taishin
authors.initials: T
authors.lastname: Ito
authors.forename: Shinji
authors.initials: S
authors.lastname: Kusunom
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Osafumi
authors.initials: O
authors.lastname: Yuge
mesh_terms: D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000767:Anesthesia, Epidural; D001943:Breast Neoplasms / Q000150:complications / Q000601:surgery; D003882:Dermatomyositis / Q000150:complications*; D020927:Dexmedetomidine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008408:Mastectomy; D012131:Respiratory Insufficiency / Q000150:complications*
chemical_list: D018712:Analgesics, Non-Narcotic; D020927:Dexmedetomidine