title: Acid and non-acid gastro-esophageal refluxes in children with chronic pulmonary diseases.
abstract: OBJECTIVE
  Acid gastro-esophageal reflux has been shown associated with chronic pulmonary diseases. The role of non-acid refluxes in these children is still unknown. Therefore we investigated the prevalence of acid and non-acid refluxes, and their association with desaturations, in children with chronic pulmonary symptoms.
  
  
  METHODS
  In 25 children aged 6 months to 15 years with unexplained chronic cough, wheeze or sputum production, refluxes were assessed by 24h-multiple intra-esophageal impedance measurements, simultaneous pH metry and continuous recording of oxygen saturation.
  
  
  RESULTS
  pH in the proximal and distal esophagus as well as six impedance channels were evaluated in all subjects. A mean of 129.4 refluxes per day per patient was detected. Complete and technically usable readings of oxygen saturation were obtained in 14 children. In this group the subjects had a mean of 112.6 refluxes and 92.6 desaturations per day per patient. The symptom index and symptom sensitivity index for acid refluxes were 34.7% and 24.6%, respectively, for non-acid refluxes 3.0% and 66.7%, respectively.
  
  
  CONCLUSIONS
  We found a high prevalence of acid reflux and a very low number of non-acid refluxes in this population. The symptom index was negative for all types of reflux, whereas the symptom sensitivity index was positive for both acid and non-acid reflux. Our data support a relation between acid gastro-esophageal refluxes and chronic pulmonary symptoms; however, this study does not support a role of non-acid reflux in children with respiratory symptoms, which are not on antacid medication.
authors.affiliation: Department of Pediatric Pulmonology, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University Munich, Lindwurmstrasse 4, D 80337 Munich, Germany.
authors.forename: Claude
authors.initials: C
authors.lastname: Thilmany
authors.forename: Julia
authors.initials: J
authors.lastname: Beck-Ripp
authors.forename: Matthias
authors.initials: M
authors.lastname: Griese
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017097:Electric Impedance; D050782:Esophageal pH Monitoring; D004947:Esophagus / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D008297:Male; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000097:blood; D012120:Respiration Disorders / Q000209:etiology* / Q000378:metabolism
chemical_list: D010100:Oxygen