CARP: fishing for novel mechanisms of neovascularization.
Gene expression profiling of mouse skin wounds has led to the discovery of numerous target genes that may have therapeutic or diagnostic value. Among these, cardiac ankyrin repeat protein (CARP, ankrd1) expression was markedly and persistently elevated in several cutaneous compartments. This review summarizes the current state of knowledge of CARP and its regulation in biological systems. In addition to its role as a nuclear transcription cofactor in many cell types including vascular endothelium, CARP is also a structural component of the sarcomere. CARP transcripts are prominent in cardiogenesis and muscle injury, and they are under complex regulation by cytokines, hypoxia, doxorubicin, and other forms of stress. CARP overexpression in wounds by adenoviral gene transfer leads to a high vascular density, and CARP exerts effects on endothelial behavior. The unusual cellular distribution and actions of CARP make it a novel candidate gene in tissue repair.
Samaras
Susan E
SE
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2561, USA.
Shi
Yubin
Y
Davidson
Jeffrey M
JM
D000818:Animals; D019610:Cytoprotection; D004317:Doxorubicin / Q000633:toxicity; D006321:Heart / Q000187:drug effects; D006801:Humans; D051379:Mice; D009124:Muscle Proteins / Q000235:genetics / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
C491304:ANKRD1 protein, human; C104844:Ankrd1 protein, mouse; D009124:Muscle Proteins; D009687:Nuclear Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; D016212:Transforming Growth Factor beta; D004317:Doxorubicin