[Development of research on tumor dormancy].
Tumor dormancy is not only a biologic character in malignant tumor cells but also the key cause of failure to the treatment, metastasis, and recurrence of tumors. In this article, the evidence of tumor dormancy in patients, the evolution of the definition of tumor dormancy, the establishment of the animal mode of tumor dormancy, and the molecular mechanism of tumor dormancy were reviewed. Recent progress on novel antitumor drugs through inducing tumor dormancy was summarized.
Che
Guo-Wei
GW
Department of Cardiovascular Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China. cheguowei@yahoo.com.cn
Liu
Lun-Xu
LX
Zhou
Qing-Hua
QH
D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D004195:Disease Models, Animal; D016147:Genes, Tumor Suppressor; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D009389:Neovascularization, Pathologic; D016192:Resting Phase, Cell Cycle