title: Origin of informational polymers: The concurrent roles of formamide and phosphates.
abstract: Formamide chemistry provides a unitary system by gathering all of the precursors needed to synthesise pregenetic informational polymers in a single milieu. This is not observed with HCN chemistry. With common catalysts, formamide affords all of the precursor nucleobases, photochemically condenses into acyclonucleosides, favours transphosphorylation and enhances micellar aggregation of surfactants. Also, formamide provides a set of physicochemical conditions that thermodynamically favour the polymeric state of nucleotides over the monomers. In the origin-of-informational-polymers scenario, formamide acts in every step, the least characterised being the set of its reactions with phosphates. On this matter, we report two complementary sets of results: 1) the synthesis of prebiotic precursors from formamide, which are catalysed by soluble and mineral phosphates-we observed the formation of rich mixtures that include uracil, 9H-purine, cytosine, dihydrouracil, hypoxanthine, adenosine, urea, parabanic acid, the amino acid N-formylglycine and the peptide-condensing agent carbodiimide; and 2) the protection of ribo- and deoxyribophosphoester bonds by phosphates. The relevance of these effects with respect to the origin of informational polymers is discussed.
authors.affiliation: Dipartimento A.B.A.C., Università della Tuscia, Via San Camillo De Lellis, 01100 Viterbo, Italy. saladino@unitus.it
authors.forename: Raffaele
authors.initials: R
authors.lastname: Saladino
authors.forename: Claudia
authors.initials: C
authors.lastname: Crestini
authors.forename: Veronica
authors.initials: V
authors.lastname: Neri
authors.forename: Fabiana
authors.initials: F
authors.lastname: Ciciriello
authors.forename: Giovanna
authors.initials: G
authors.lastname: Costanzo
authors.forename: Ernesto
authors.initials: E
authors.lastname: Di Mauro
mesh_terms: D002384:Catalysis; D004247:DNA / Q000235:genetics; D005559:Formamides / Q000737:chemistry*; D008903:Minerals / Q000737:chemistry; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012313:RNA / Q000235:genetics; D012995:Solubility
chemical_list: D005559:Formamides; D008903:Minerals; D010710:Phosphates; D011108:Polymers; C471364:pyromorphite; C031066:formamide; D012313:RNA; D004247:DNA