title: [Nodular alveolar pattern of presentation for amiodarone pulmonary toxicity].
abstract: Amiodarone is a triiodinated antiarrhythmic drug that accumulates in alveolar macrophages. Its use is limited by its high rate of associated pulmonary toxicity, estimated at 5-7%. Radiologic findings for pulmonary toxicity caused by amiodarone are unspecific and varied. The most common finding is subpleural reticular-type interstitial thickening, predominately in the bases of the lungs. However, the presence of parenchymal nodules is an uncommon presentation. We report the case of a woman treated with amiodarone that presented multiple nodular lesions at plain-film radiography and high-resolution CT that were compatible with pulmonary toxicity caused by amiodarone at pathologic examination.
authors.affiliation: Servicio de Radiología, Hospital Universitario Ramón y Cajal, Crta de Colmenar Viejo km 9,10, 2834 Madrid, España. cggordaliza@mixmail.com
authors.forename: M C
authors.initials: MC
authors.lastname: González Gordaliza
authors.forename: A
authors.initials: A
authors.lastname: Vicente Bártulos
authors.forename: J A
authors.initials: JA
authors.lastname: Sánchez Corral
authors.forename: E
authors.initials: E
authors.lastname: Bernal Morell
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone