[Malnutrition, inflammation and atherosclerosis (MIA-syndrome) in dialysis patients].
Malnutrition and chronic inflammation are frequently-occurring complications in dialysis patients. These conditions are associated with cardiovascular diseases and predict hospitalisation and mortality. There is assumed to be a pathophysiologic association between malnutrition, inflammation and atherosclerosis in this patient population. Indeed, chronic inflammation can induce an atherogenic and catabolic state, while a low food intake can lead to malnutrition and inflammation, but can also result from it. These complex associations constitute the basis for 'malnutrition, inflammation and atherosclerosis (MIA syndrome)'. Inflammation and malnutrition associated atherosclerosis may explain a large part of the high mortality in dialysis patients. An integrated approach is needed to treat this multifactorial complication. Randomised clinical trials on this subject are lacking as yet.
de Mutsert
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Leids Universitair Medisch Centrum, afd Klinische Epidemiologie, Leiden.
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D001161:Arteriosclerosis / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000401:mortality / Q000628:therapy; D044342:Malnutrition / Q000209:etiology*; D006435:Renal Dialysis / Q000009:adverse effects* / Q000401:mortality; D013577:Syndrome