title: Neural mechanisms for response selection: comparing selection of responses and items from working memory.
abstract: Recent functional imaging studies of working memory (WM) have suggested a relationship between the requirement for response selection and activity in dorsolateral prefrontal (DLPFC) and parietal regions. Although a number of WM operations are likely to occur during response selection, the current study was particularly interested in the contribution of this neural network to WM-based response selection when compared to the selection of an item from a list being maintained in memory, during a verbal learning task. The design manipulated stimulus-response mappings so that selecting an item from memory was not always accompanied with selecting a motor response. Functional activation during selection supported previous findings of fronto-parietal involvement, although in contrast to previous findings left, rather than right, DLPFC activity was significantly more active for selecting a memory-guided motor response, when compared to selecting an item currently maintained in memory or executing a memory-guided response. Our results contribute to the debate over the role of fronto-parietal activity during WM tasks, suggesting that this activity appears particularly related to response selection, potentially supporting the hypothesized role of prefrontal activity in biasing attention toward task-relevant material in more posterior regions.
authors.affiliation: Department of Psychology, University of Melbourne, Melbourne, Australia. hesterr@unimelb.edu.au
authors.forename: Robert
authors.initials: R
authors.lastname: Hester
authors.forename: Mark
authors.initials: M
authors.lastname: D'Esposito
authors.forename: Michael W
authors.initials: MW
authors.lastname: Cole
authors.forename: Hugh
authors.initials: H
authors.lastname: Garavan
mesh_terms: D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*