title: Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report.
abstract: Systemic lupus erythematosus (SLE) and autoimmune hepatitis are distinct clinical disorders, which rarely occur, in the same patient. We describe a 59-year-old woman with coexistence of both conditions. Photosensitivity, arthritis, positive ANA, and extreme elevation of anti-dsDNA concluded the diagnosis of SLE. Hyperbilirubinemia, high serum value of liver function, and elevation of alpha-fetoprotein were also prominent. By a review of pertinent literature, clinical investigation, calculation of autoimmune hepatitis score, and pathology of liver biopsy specimen, we were in favor of autoimmune hepatitis. Awareness of this rare presentation may be beneficial to clinicians in identifying and treating patients with both SLE and autoimmune hepatitis.
authors.affiliation: Division of Rheumatology/Immunology/Allergy, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan, ROC. lfc10399@yahoo.com.tw
authors.forename: Feng-Cheng
authors.initials: FC
authors.lastname: Liu
authors.forename: Deh-Ming
authors.initials: DM
authors.lastname: Chang
authors.forename: Jenn-Huang
authors.initials: JH
authors.lastname: Lai
authors.forename: Chih-Kung
authors.initials: CK
authors.lastname: Lin
authors.forename: Hsiang-Cheng
authors.initials: HC
authors.lastname: Chen
authors.forename: Tsung-Yun
authors.initials: TY
authors.lastname: Hou
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Kuo
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000276:immunology / Q000378:metabolism*
chemical_list: D000509:alpha-Fetoproteins