title: Regressing anaplastic CD30-positive large-cell lymphoma of the skin.
abstract: Originally believed to be of histiocytic origin, regressing primary cutaneous anaplastic large-cell lymphoma is a CD30 (Ki 1) positive T-cell lymphoma with histologic high grade malignancy, but with an often favorable clinical course with regression of individual lesions. We present a case of a 69-year-old white woman with an 8-month history of noduloulcerative lesions on her right lower leg, otherwise in good general health. The clinical, histologic, and immunohistochemical findings pointed to CD30 positive primary cutaneous anaplastic large-cell lymphoma. There were no signs of generalization, lymph node or internal organ involvement. After 2 years of activity, the disease regressed. During the 10-year follow-up period, no signs of disease reactivation were noted. Accurate recognition of this lymphoma is important to avoid unnecessary aggressive treatments.
authors.affiliation: Department of Dermatology, School of Medicine, University of Belgrade, Pasterova 2, 11000 Belgrade, Serbia.
authors.forename: Dusan
authors.initials: D
authors.lastname: Skiljevic
authors.forename: Milos M
authors.initials: MM
authors.lastname: Nikolic
authors.forename: Mirjana
authors.initials: M
authors.lastname: Milinkovic
authors.forename: Branka
authors.initials: B
authors.lastname: Bonaci-Nikolic
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007866:Leg; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000473:pathology; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology