title: Telithromycin-nonsusceptible clinical isolates of Streptococcus pneumoniae from Europe.
abstract: Telithromycin-nonsusceptible pneumococcal clinical isolates (n = 17) were analyzed for their antimicrobial susceptibility, macrolide resistance mechanisms, and genetic relatedness. All strains showed the erm(B) genotype and showed a wide range of combinations of macrolide resistance mechanisms. The predominant clone (n = 7) was serotype 14, sequence type 143.
authors.affiliation: Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital (RWTH), Pauwelsstr. 30, Aachen, Germany.
authors.forename: Adnan
authors.initials: A
authors.lastname: Al-Lahham
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
authors.forename: Mark
authors.initials: M
authors.lastname: van der Linden
authors.forename: Ralf René
authors.initials: RR
authors.lastname: Reinert
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005060:Europe; D005838:Genotype; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010641:Phenotype; D011008:Pneumococcal Infections / Q000382:microbiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; C106791:telithromycin