title: Synthesis of the penta-oxazole core of telomestatin in a convergent approach to poly-oxazole macrocycles.
abstract: A protocol for the construction of poly-oxazoles with consecutive 2,4'-linkages is described, and has afforded an efficient route to a penta-oxazole which demarcates a route to telomestatin and related macrocyclic poly-oxazole systems.
authors.affiliation: Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, WC1H 0AJ, UK. c.m.marson@ucl.ac.uk
authors.forename: Charles M
authors.initials: CM
authors.lastname: Marson
authors.forename: Mona
authors.initials: M
authors.lastname: Saadi
mesh_terms: D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D047028:Macrocyclic Compounds; D010080:Oxazoles; C431888:telomestatin