title: Blood coagulation unaffected by ozonated autohemotherapy in patients on maintenance hemodialysis.
abstract: BACKGROUND
  Ozonated autohemotherapy (O(3)-AHT) is a clinically useful therapeutic procedure in hemodialyzed patients with peripheral arterial occlusive disease (PAOD). The majority of patients on dialysis are in a hypercoagulable state. Thrombotic complications are the major cause of morbidity and mortality in hemodialyzed patients. Effects of O(3)-AHT on blood coagulation were evaluated in 11 hemodialyzed patients affected by PAOD.
  
  
  METHODS
  We performed an oxygen-controlled, crossover study in which nine sessions of autohemotherapy with oxygen administration (AHT) as a control were followed by nine sessions of O(3)-AHT. Blood coagulation was assessed by antithrombin III, activated partial thromboplastin time, prothrombin time, D-dimer and fibrinogen plasma concentrations.
  
  
  RESULTS
  The extents of all the measured parameters after nine sessions of O(3)-AHT did not differ statistically from the values after nine sessions of AHT. Similarly, there were no differences in the measured variables after the first session of O(3)-AHT as compared to the values before therapy. We did not observe any thrombotic accidents during the study.
  
  
  CONCLUSIONS
  O(3)-AHT with ozone concentration of 50 microg/mL and citrate as an anticoagulant does not influence blood coagualation parameters in hemodialyzed patients with PAOD.
authors.affiliation: Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Biedunkiewicz
authors.forename: Slawomir
authors.initials: S
authors.lastname: Lizakowski
authors.forename: Leszek
authors.initials: L
authors.lastname: Tylicki
authors.forename: Anna
authors.initials: A
authors.lastname: Skiboeska
authors.forename: Tomas
authors.initials: T
authors.lastname: Nieweglowski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Chamienia
authors.forename: Alicja
authors.initials: A
authors.lastname: Debska-Slizien
authors.forename: Boleslaw
authors.initials: B
authors.lastname: Rutkowski
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000628:therapy*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001804:Blood Transfusion, Autologous / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000627:therapeutic use*; D016491:Peripheral Vascular Diseases / Q000188:drug therapy / Q000628:therapy*; D006435:Renal Dialysis; D017211:Treatment Failure
chemical_list: D010126:Ozone