Tissue engineering for tendon repair.
Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.
Bagnaninchi
Pierre-Olivier
PO
Institute of Science and Technology in Medicine, Keele University, Hartshill, UK.
Yang
Ying
Y
El Haj
Alicia J
AJ
Maffulli
Nicola
N
D001672:Biocompatible Materials; D005260:Female; D006801:Humans; D008297:Male; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures / Q000379:methods*; D012038:Regeneration / Q000502:physiology; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D052256:Tendinopathy / Q000601:surgery; D013708:Tendon Injuries / Q000601:surgery*; D013710:Tendons / Q000502:physiology / Q000601:surgery*; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials