title: Antimicrobial susceptibility of non-enterococcal intrinsic glycopeptide-resistant Gram-positive organisms.
abstract: Non-enterococcal Gram-positive bacteria that are intrinsically vancomycin-resistant have been infrequently isolated in association with serious infections. However, well-documented infections have lately been reported with increasing frequency. Because these organisms may be pathogens, we tested the MICs of 19 antimicrobial agents by the agar dilution method for predicting susceptibility. The activity of these antimicrobial agents was assessed against 28 strains (Lactobacillus rhamnosus, 6; Lactobacillus acidophilus, 1; Lactobacillus casei, 1; Lactobacillus fermentum, 2; Lactobacillus brevis, 1; Lactobacillus plantarum, 1; Weissella confusa, 2; Leuconostoc mesenteroides, 7; Leuconostoc lactis, 4; Pediococcus acidilactici, 2; Pediococcus pentosaceus, 1), isolated from clinical specimens in an Argentinian university hospital from 1997 to 2003. The MICs of penicillin for 67% of the Lactobacillus strains and 100% of the Leuconostoc spp. and Pediococcus spp. strains tested were in the 0.25-2 microg/mL range. Erythromycin was the most active antimicrobial overall. Multiresistance was observed in 2 strains (Lactobacillus rhamnosus, 1; Lactobacillus plantarum, 1).
authors.affiliation: Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas, Universidad de Buenos Aires, Argentina, CP 1407, Buenos Aires, Argentina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Vay
authors.forename: Roxana
authors.initials: R
authors.lastname: Cittadini
authors.forename: Claudia
authors.initials: C
authors.lastname: Barberis
authors.forename: Carlos
authors.initials: C
authors.lastname: Hernán Rodríguez
authors.forename: Herminia
authors.initials: H
authors.lastname: Perez Martínez
authors.forename: Fabiana
authors.initials: F
authors.lastname: Genero
authors.forename: Angela
authors.initials: A
authors.lastname: Famiglietti
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001118:Argentina; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D006020:Glycopeptides / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006785:Hospitals, University; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D004917:Erythromycin