title: [Study on relative bioavailability of ferulic acid of combination Radix Angelicae Sinensis and Cortex Cinnamomi in mice].
abstract: OBJECTIVE
  To study the phamacokinetics and relative bioavailability of combination Radix Angelicae Sinensis and Cortex Cinnamomi.
  
  
  METHODS
  The content of ferulic acid in plasma was determined directly by HPLC after oral administration of Cortex Cinnamomi in combination individually with Radix Angelicae Sinensis. The plasma concentration-time curve were plotted. The main pharmacokinetic parameters and relative bioavailability were obtained.
  
  
  RESULTS
  The plasma concentration-time curve of fenalic aclid conformed to one-compartment model. The relative bioavailability of Cortex Cinnamomi combined with Radix Angelicae Sinensis were 226.75%.
  
  
  CONCLUSIONS
  By the statistical analysis, Cortex Cinnamomi combined with Radix Angelicae Sinensis can increase the relative bioavailability of ferulic acid.
authors.affiliation: Sichuan Cancer Institute, Chengdu 610041, China.
authors.forename: Zu-yi
authors.initials: ZY
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Pei
authors.forename: Rong-min
authors.initials: RM
authors.lastname: Liu
authors.forename: Jia
authors.initials: J
authors.lastname: Cheng
authors.forename: De-guang
authors.initials: DG
authors.lastname: Wan
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D001682:Biological Availability; D032904:Cinnamomum aromaticum / Q000737:chemistry; D003373:Coumaric Acids / Q000097:blood / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D003373:Coumaric Acids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C004999:ferulic acid