D-serine in the developing human central nervous system.
To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development.
Fuchs
Sabine A
SA
Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. s.fuchs@umcutrecht.nl
Dorland
Lambertus
L
de Sain-van der Velden
Monique G
MG
Hendriks
Margriet
M
Klomp
Leo W J
LW
Berger
Ruud
R
de Koning
Tom J
TJ
D002490:Central Nervous System / Q000254:growth & development* / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005998:Glycine / Q000134:cerebrospinal fluid / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D050543:Phosphoglycerate Dehydrogenase / Q000172:deficiency; D012694:Serine / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000502:physiology*; D013237:Stereoisomerism
D012694:Serine; D050543:Phosphoglycerate Dehydrogenase; D005998:Glycine