title: Rheological behavior of gels and meloxicam release.
abstract: The aim of this work was to identify a gel with suitable organoleptic and rheological properties (spreadability, texture and viscosity) for topical administration, designed to allow fast release of the active principle. The release of Meloxicam (anti-inflammatory agent) from olive oil lipogels was compared with a Carbopol hydrophilic prepared gel. In order to improve the diffusion of the active principle, two different artificial membranes with different pore size were used, before release assays in diffusion cells were compared. Drug released rate were obtained by Higuchi's model. Release rate and rheological properties relations were studied, and the best results were obtained for the gel prepared with an olive oil emulgent (Olivem 900).
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Granada, E-18071 Granada, Spain. adolfina@ugr.es
authors.forename: Maria Adolfina
authors.initials: MA
authors.lastname: Ruiz Martinez
authors.forename: Julián
authors.initials: J
authors.lastname: López-Viota Gallardo
authors.forename: María Muñoz
authors.initials: MM
authors.lastname: de Benavides
authors.forename: Juan
authors.initials: J
authors.lastname: de Dios García López-Duran
authors.forename: Visitación
authors.initials: V
authors.lastname: Gallardo Lara
mesh_terms: D000180:Acrylic Resins; D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004337:Drug Carriers; D004355:Drug Stability; D005782:Gels; D007700:Kinetics; D000077239:Meloxicam; D008567:Membranes, Artificial; D008956:Models, Chemical; D000069463:Olive Oil; D009991:Oscillometry; D010938:Plant Oils / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D016062:Porosity; D012212:Rheology / Q000379:methods; D033081:Shear Strength; D012995:Solubility; D013696:Temperature; D013843:Thiazines / Q000008:administration & dosage / Q000737:chemistry*; D013844:Thiazoles / Q000008:administration & dosage / Q000737:chemistry*; D014783:Viscosity
chemical_list: D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005782:Gels; D008567:Membranes, Artificial; D000069463:Olive Oil; D010938:Plant Oils; D011145:Polyvinyls; D013843:Thiazines; D013844:Thiazoles; C006912:carboxypolymethylene; D000077239:Meloxicam