Comparison of two indices of exposure to polycyclic aromatic hydrocarbons in a retrospective aluminium smelter cohort.
BACKGROUND
The association between coal tar-derived substances, a complex mixture of polycyclic aromatic hydrocarbons, and cancer is well established. However, the specific aetiological agents are unknown.


OBJECTIVE
To compare the dose-response relationships for two common measures of coal tar-derived substances, benzene-soluble material (BSM) and benzo(a)pyrene (BaP), and to evaluate which among these is more strongly related to the health outcomes.


METHODS
The study population consisted of 6423 men with > or =3 years of work experience at an aluminium smelter (1954-97). Three health outcomes identified from national mortality and cancer databases were evaluated: incidence of bladder cancer (n = 90), incidence of lung cancer (n = 147) and mortality due to acute myocardial infarction (AMI, n = 184). The shape, magnitude and precision of the dose-response relationships and cumulative exposure levels for BSM and BaP were evaluated. Two model structures were assessed, where 1n(relative risk) increased with cumulative exposure (log-linear model) or with log-transformed cumulative exposure (log-log model).


RESULTS
The BaP and BSM cumulative exposure metrics were highly correlated (r = 0.94). The increase in model precision using BaP over BSM was 14% for bladder cancer and 5% for lung cancer; no difference was observed for AMI. The log-linear BaP model provided the best fit for bladder cancer. The log-log dose-response models, where risk of disease plateaus at high exposure levels, were the best-fitting models for lung cancer and AMI.


CONCLUSIONS
BaP and BSM were both strongly associated with bladder and lung cancer and modestly associated with AMI. Similar conclusions regarding the associations could be made regardless of the exposure metric.
Friesen
Melissa C
MC
Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada. melissaf@interchange.ubc.ca
Demers
Paul A
PA
Spinelli
John J
JJ
Lorenzi
Maria F
MF
Le
Nhu D
ND
D000395:Air Pollutants, Occupational / Q000032:analysis / Q000633:toxicity*; D000535:Aluminum; D001554:Benzene / Q000032:analysis / Q000633:toxicity*; D001564:Benzo(a)pyrene / Q000032:analysis* / Q000633:toxicity*; D001955:British Columbia / Q000453:epidemiology; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000401:mortality; D008297:Male; D008669:Metallurgy; D009203:Myocardial Infarction; D016273:Occupational Exposure; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000401:mortality
D000395:Air Pollutants, Occupational; D001564:Benzo(a)pyrene; D000535:Aluminum; D001554:Benzene