[Study on comparative pharmacology of series of Muskone].
OBJECTIVE
To study the therapeutic effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on experimental myocardial infarct and pain in rats.


METHODS
Coronary artery ligation was applied for the model of myocardial infarct. Therapeutic effects were evaluated by measuring parameters of histomorphometry, blood plasm of ET, 6- keto-PGF1alpha and TXB2. Intraperitoneal injection acetic was applied for the model of ache, the frequency and eclipse period of writhing were evaluated its effect of resisting pain.


RESULTS
The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all can decrease the area of myocardial infarction in rats, the level of TXB2, ET, and the frequency of writhing significantly. Also it can increase the level 6-keto-PGF1alpha, the ratio of 6-keto-PGF1alpha and TXB2. Single Radix Aristolociae or Radix Inulae only relieved pain.


CONCLUSIONS
The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all have significant therapeutic effect on both myocardial infarction and pain, while single Radix Aristolociae or Radix Inulae only can relieve pain.
Ma
Kun
K
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100700, China. makun123@sohu.com
Zhang
Jin-Yan
JY
Li
Yi-Kui
YK
Zhang
Yong-Tao
YT
Wu
Li-Mao
LM
Li
Xiang-Ri
XR
Pan
Li
L
Li
Lian-Da
LD
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D030022:Aristolochia / Q000737:chemistry; D003516:Cycloparaffins / Q000302:isolation & purification / Q000494:pharmacology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D016232:Endothelins / Q000097:blood; D005260:Female; D038143:Inula / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009203:Myocardial Infarction / Q000188:drug therapy*; D010146:Pain / Q000503:physiopathology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013929:Thromboxane B2 / Q000097:blood
D003516:Cycloparaffins; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C031021:muscone