title: Recurrent immune thrombocytopenic purpura in children.
abstract: Recurrent immune thrombocytopenic purpura (ITP) is defined as the recurrence of ITP after at least 3 months of remission sustained without treatment. Among 340 children with ITP, 14 had recurrent ITP (4.1%). Ten were females. The initial course was acute in 8 patients and chronic in 6. The median time to recurrence was 33 months (range 4-120). Only 1 patient had a second recurrence. Twelve (86%) achieved complete (n = 10) or partial (n = 2) remission, two of them after splenectomy. One patient continued to require treatment at 10 months from recurrence. One child died of intracranial hemorrhage despite aggressive treatment including splenectomy and craniotomy.
authors.affiliation: Department of Pediatrics, New York Medical College, Valhalla, New York, USA. s_jayabose@nymc.edu
authors.forename: Somasundaram
authors.initials: S
authors.lastname: Jayabose
authors.forename: Oya
authors.initials: O
authors.lastname: Levendoglu-Tugal
authors.forename: Mehmet F
authors.initials: MF
authors.lastname: Ozkaynak
authors.forename: Claudio
authors.initials: C
authors.lastname: Sandoval
mesh_terms: D000293:Adolescent; D000328:Adult; D002543:Cerebral Hemorrhage / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010976:Platelet Count; D011241:Prednisone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000453:epidemiology* / Q000601:surgery / Q000628:therapy; D012008:Recurrence; D012074:Remission Induction; D013156:Splenectomy
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D011241:Prednisone; D008775:Methylprednisolone