Synthesis of Staphylococcus aureus lipoteichoic acid derivatives for determining the minimal structural requirements for cytokine induction.
For the investigation of the minimal structural requirements for cytokine induction, Staphylococcus aureus lipoteichoic acid derivatives with two, three, four, and five glycerophosphate backbone moieties, carrying each a d-alanyl residue, were needed. Based on two different glycerophosphate building blocks and 6b-O-phosphitylated gentiobiosyl diacylglycerol the desired target molecules (compounds 1-4) could be readily obtained and provided for biological studies.
Figueroa-Perez
Ignacio
I
Fachbereich Chemie, Universität Konstanz, Fach M 725, D-78457 Konstanz, Germany.
Stadelmaier
Andreas
A
Deininger
Susanne
S
Aulock
Sonja von
Sv
Hartung
Thomas
T
Schmidt
Richard R
RR
D016207:Cytokines / Q000096:biosynthesis*; D004187:Disaccharides / Q000737:chemistry; D005994:Glycerophosphates / Q000737:chemistry; D008070:Lipopolysaccharides / Q000138:chemical synthesis*; D013211:Staphylococcus aureus / Q000737:chemistry; D013329:Structure-Activity Relationship; D013682:Teichoic Acids / Q000138:chemical synthesis*
D016207:Cytokines; D004187:Disaccharides; D005994:Glycerophosphates; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid; C100052:gentiobiose