Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.
Adiponectin/adiponectin receptors (AdipoR) are involved in energy homeostasis and inflammatory pathways. To investigate the role of AdipoR2 in metabolic control, we studied the lipid and glucose metabolic phenotypes in AdipoR2-deficient mice. AdipoR2 deletion diminished high-fat diet-induced dyslipidemia and insulin resistance yet deteriorated glucose homeostasis as high-fat feeding continued, which resulted from the failure of pancreatic beta-cells to adequately compensate for the moderate insulin resistance. A defect in the AdipoR2 gene may represent a mechanism underlying the etiology of certain subgroups of type 2 diabetic patients who eventually develop overt diabetes, whereas other obese patients do not.
Liu
Yanfang
Y
Type 2 Diabetes Drug Hunting Team, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
Michael
M Dodson
MD
Kash
Shera
S
Bensch
William R
WR
Monia
Brett P
BP
Murray
Susan F
SF
Otto
Keith A
KA
Syed
Samreen K
SK
Bhanot
Sanjay
S
Sloop
Kyle W
KW
Sullivan
John M
JM
Reifel-Miller
Anne
A
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D050171:Dyslipidemias / Q000503:physiopathology; D002149:Energy Intake; D005947:Glucose / Q000378:metabolism; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism; D050356:Lipid Metabolism / Q000235:genetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D054419:Receptors, Adiponectin; D011956:Receptors, Cell Surface / Q000172:deficiency*; D015430:Weight Gain
D001786:Blood Glucose; D004041:Dietary Fats; D054419:Receptors, Adiponectin; D011956:Receptors, Cell Surface; C475421:adiponectin receptor 2, mouse; D005947:Glucose