title: Imaging of trabeculectomy blebs using anterior segment optical coherence tomography.
abstract: OBJECTIVE
  To image trabeculectomy blebs using anterior segment optical coherence tomography (AS-OCT).
  
  
  METHODS
  Prospective cross-sectional study.
  
  
  METHODS
  Fifty-five patients who had previously undergone trabeculectomy surgery.
  
  
  METHODS
  All blebs were imaged with a prototype of the AS-OCT. Standardized color monophotographs of blebs were also obtained. Blebs were assessed for the following qualitative features: bleb height, thickness of the conjunctiva in the bleb wall, presence of cystic spaces within the bleb wall, apposition of the scleral flap to underlying sclera, and patency of the internal ostium.
  
  
  METHODS
  For blebs with preoperative intraocular pressure (IOP) > 18 mmHg with or without ocular hypotensive medication, success was defined as last recorded IOP< or =18 mmHg without topical glaucoma medication. For blebs with preoperative IOP< or =18 mmHg with ocular hypotensive medication, success was defined last recorded IOP< or =18 mmHg with cessation of ocular hypotensive medication. For blebs with preoperative IOP< or =18 mmHg without ocular hypotensive medication, a 20% drop in IOP with no ocular hypotensive medication was accepted as success.
  
  
  RESULTS
  Seventy-eight blebs in eyes of 55 patients were imaged. There were 32 (58.2%) men and the mean age was 68.9+/-11.5 years. Fifty-seven (73.1%) blebs were classified as successful. Anterior segment optical coherence tomography identified the following bleb characteristics: total bleb height, bleb cavity, bleb wall thickness, tangential and radial dimensions, scleral flap thickness, and patency of the internal ostium. The majority of successful blebs displayed thickening of the bleb wall. Failed blebs were mostly low and were characterized by ostial occlusion, apposition of conjunctiva-episclera to sclera or apposition of the scleral flap to its bed. Thickening of the bleb wall was typically absent.
  
  
  CONCLUSIONS
  AS-OCT is a promising tool to image trabeculectomy blebs. It was able to demonstrate features of bleb morphology not visible with the slit lamp.
authors.affiliation: National University Hospital, Singapore.
authors.forename: Mandeep
authors.initials: M
authors.lastname: Singh
authors.forename: Paul T K
authors.initials: PT
authors.lastname: Chew
authors.forename: David S
authors.initials: DS
authors.lastname: Friedman
authors.forename: Winifred P
authors.initials: WP
authors.lastname: Nolan
authors.forename: Jovina L
authors.initials: JL
authors.lastname: See
authors.forename: Scott D
authors.initials: SD
authors.lastname: Smith
authors.forename: Ce
authors.initials: C
authors.lastname: Zheng
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Foster
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
mesh_terms: D000368:Aged; D000869:Anterior Eye Segment / Q000473:pathology*; D001768:Blister / Q000175:diagnosis*; D003228:Conjunctiva / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D011446:Prospective Studies; D012590:Sclera / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014130:Trabeculectomy