title: A soft deformable tissue-equivalent phantom for diffuse optical tomography.
abstract: A recipe is presented for the manufacture of highly compressible phantoms for diffuse optical tomography. The recipe is based on polyvinyl alcohol (PVA) slime, a viscoelastic fluid which readily deforms under moderate pressure. Scattering particles and absorbing compounds can be added to provide a uniform material with stable and reproducible optical properties. A linear relationship between the concentration of scattering particles (either titanium dioxide or microspheres) and the transport scatter coefficient is demonstrated. Phantoms of an arbitrary size and shape may be produced by containing the slime within a thin latex shell, and a stability over a period of at least 3 months has been established. The deformable phantoms may be used to test and calibrate optical tomography systems designed for use on patients with irregular or variable geometries.
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Hebden
authors.forename: Ben D
authors.initials: BD
authors.lastname: Price
authors.forename: Adam P
authors.initials: AP
authors.lastname: Gibson
authors.forename: Gary
authors.initials: G
authors.lastname: Royle
mesh_terms: D000042:Absorption; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004548:Elasticity; D006801:Humans; D007840:Latex / Q000737:chemistry; D008863:Microspheres; D019047:Phantoms, Imaging; D011137:Polystyrenes / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012542:Scattering, Radiation; D014025:Titanium / Q000737:chemistry; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods*
chemical_list: D003432:Cross-Linking Reagents; D007840:Latex; D011137:Polystyrenes; C009495:titanium dioxide; D011142:Polyvinyl Alcohol; D014025:Titanium