title: The PKA-CREB system encoded by the honeybee genome.
abstract: The cAMP-dependent kinase (PKA) plays a crucial part in long-term memory formation in the honeybee (Apis mellifera). One of the putative substrates of the PKA activity is the cAMP response element binding protein (CREB), a transcription factor in the bZIP protein family. We searched the honeybee genome to characterize genes from the CREB/CREM and the PKA families. We identified two genes that encode regulatory subunits and three genes encode catalytic subunits of PKA. Eight genes code for bZIP proteins, but only one gene was found that encodes a member of the CREB/CREM family. The phylogenetic relationship of these genes was analysed with their Drosophila and human counterparts.
authors.affiliation: Neurobiology, FB Biology/Chemistry/Pharmacy, Freie Universität Berlin, Berlin, Germany. theodora@neurobiologie.fu-berlin.de
authors.forename: D
authors.initials: D
authors.lastname: Eisenhardt
authors.forename: C
authors.initials: C
authors.lastname: Kühn
authors.forename: G
authors.initials: G
authors.lastname: Leboulle
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics; D001516:Bees / Q000235:genetics*; D020134:Catalytic Domain / Q000235:genetics; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics*; D004330:Drosophila / Q000235:genetics; D040461:Gene Components; D017344:Genes, Insect; D006801:Humans; D050436:Regulatory Elements, Transcriptional; D017386:Sequence Homology, Amino Acid
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D017362:Cyclic AMP Response Element-Binding Protein; D017868:Cyclic AMP-Dependent Protein Kinases