Synthesis and anti-inflammatory activities investigation of sinomenine derivatives on ring C.
Eighteen sinomenine derivatives on ring C were prepared, and their anti-inflammatory activities were also investigated. Most of these derivatives showed mild to moderate activities. Compounds 4a, 4c and 5b showed better anti-inflammatory activity. So further modification of the ring C in sinomenine should be worthwhile.
Tang
Qiang
Q
Department of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China.
Luo
Juan
J
Zhu
Qianli
Q
Li
Yin
Y
Yin
Shufan
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000627:therapeutic use*; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009019:Morphinans / Q000737:chemistry* / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009019:Morphinans; C009271:sinomenine