Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation.
LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory disorders. BLT1, a G-protein-coupled receptor, has recently been identified as a high affinity receptor specific for LTB4. Recent studies in allergen-induced airway hyperresponsiveness and inflammation using mice lacking BLT1 have shown crucial new roles for leukotriene B4 and BLT1 in Th2 cytokine IL-13 production from lung T cells and recruitment of antigen-specific effector CD8+ T cells, suggesting novel mechanisms for their actions. The leukotriene B4-BLT1 pathway is an important target for the treatment of bronchial asthma.
Miyahara
Nobuaki
N
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.
Miyahara
Satoko
S
Takeda
Katsuyuki
K
Gelfand
Erwin W
EW
D000485:Allergens / Q000276:immunology*; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D007975:Leukotriene B4 / Q000502:physiology*; D018102:Receptors, Leukotriene B4 / Q000502:physiology*; D012130:Respiratory Hypersensitivity / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D015398:Signal Transduction / Q000502:physiology*
D000485:Allergens; C513240:LTB4R protein, human; C503704:Ltb4r1 protein, mouse; D018102:Receptors, Leukotriene B4; D007975:Leukotriene B4