Expression of MxA protein in blood lymphocytes of children receiving anticancer chemotherapy.
The aim of the study was to evaluate whether IFN-alpha/beta-inducible MxA protein expression in children receiving anticancer treatment can be used as an indicator for virus infections during the febrile episodes. Twenty-six children with mainly hematological malignancies entered the study. Children with laboratory-confirmed virus infections had clearly elevated MxA protein levels compared to their counterparts with bacterial or unknown etiology. MxA protein expression increased moderately following the administration of cytostatic agents, even though these children had no clinical signs of infection.
Koskenvuo
Minna M
MM
Turku Immunology Centre and Departments of Pediatrics and Virology, University of Turku, Turku, Finland. Minna.Koskenvuo@utu.fi
Halminen
Markus
M
Blomqvist
Miia
M
Vainionpää
Raija
R
Ilonen
Jorma
J
Julkunen
Ilkka
I
Salmi
Toivo T
TT
Mäkelä
Mika J
MJ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004198:Disease Susceptibility; D005260:Female; D005334:Fever / Q000097:blood / Q000209:etiology; D019204:GTP-Binding Proteins / Q000097:blood*; D019337:Hematologic Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D016898:Interferon-alpha / Q000502:physiology; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D064547:Myxovirus Resistance Proteins; D009369:Neoplasms / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D011237:Predictive Value of Tests; D014777:Virus Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis
D015415:Biomarkers; D016898:Interferon-alpha; C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; D019204:GTP-Binding Proteins