Cerebral infarction in Hunter syndrome.
Hunter syndrome, or mucopolysaccharidosis type II, is an X-linked recessive disorder resulting from iduronate sulfatase deficiency. Typical manifestations include short stature, mental retardation, hydrocephalus, macroglossia and cardiac valvulopathy. We describe a 21-year-old patient who presented with acute ischemic stroke and evidence of cerebral embolization. The echocardiogram demonstrated thickened mitral and aortic valves as potential sources of emboli. We conclude that ischemic stroke secondary to cardioembolization is a potential complication of Hunter syndrome.
Neely
John
J
Department of Neurology, University of California at San Francisco, San Francisco, California, USA.
Carpenter
Jeffrey
J
Hsu
Wesley
W
Jordan
Lori
L
Restrepo
Lucas
L
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D002550:Cerebral Veins / Q000002:abnormalities / Q000503:physiopathology; D004452:Echocardiography; D006349:Heart Valve Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006351:Heart Valves / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D020766:Intracranial Embolism / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D019586:Intracranial Hypertension / Q000209:etiology / Q000503:physiopathology; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D016532:Mucopolysaccharidosis II / Q000150:complications* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000925:Anticoagulants