title: Epidemiology and outcome of bacterial meningitis in Canadian children: 1998-1999.
abstract: BACKGROUND
  The introduction of Hemophilus influenzae type b (Hib) conjugate vaccine as part of the routine childhood vaccination schedule in Canada has resulted in a dramatic reduction in the cases of Hib meningitis. We describe the epidemiology and outcome of bacterial meningitis in Canadian children six years after the introduction of Hib conjugate vaccine and prior to the introduction of the conjugate Streptococcus pneumoniae vaccine.
  
  
  METHODS
  A retrospective chart review from January 1998 to December 1999 of children with meningitis identified at eight Canadian tertiary care children's hospitals belonging to the PICNIC network.
  
  
  RESULTS
  Bacterial meningitis was documented in 104 (11%) of 970 children presenting with meningitis. The most common isolated organisms were: Streptococcus pneumoniae (54%), group B streptococci (13%), and Neisseria meningitidis (11%). The mean age was 2.2 +/- 3.5 yr. Forty seven percent of the children required admission to Intensive Care Unit (ICU), and 19% required artificial ventilation. Sequelae were documented among 32 children (31%) prior to discharge and there were 6 (5.6%) deaths attributable to meningitis and sepsis.
  
  
  CONCLUSIONS
  Bacterial meningitis is an important cause of morbidity in Canadian children with S. pneumoniae replacing H. influenzae as the leading potentially vaccine preventable cause. Despite proper initiation of antimicrobial therapy, meningitis results in great morbidity and mortality in children in Canada.
authors.affiliation: Division of Infectious & Immunologic Diseases, British Columbia Children's Hospital, Vancouver, BC.
authors.forename: E
authors.initials: E
authors.lastname: Husain
authors.forename: R
authors.initials: R
authors.lastname: Chawla
authors.forename: S
authors.initials: S
authors.lastname: Dobson
authors.forename: H
authors.initials: H
authors.lastname: Dele Davies
mesh_terms: D016667:Bacterial Capsules; D002170:Canada / Q000453:epidemiology; D002675:Child, Preschool; D018073:Haemophilus Vaccines / Q000276:immunology; D019741:Haemophilus influenzae type b / Q000276:immunology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D008585:Meningitis, Meningococcal / Q000453:epidemiology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000276:immunology
chemical_list: D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial