Distribution of signal transducer and activator of transcription 6 gene G2964A polymorphism in Chinese patients with ulcerative colitis.
OBJECTIVE
The signal transducer and activator of transcription 6 (STAT6) gene is located on chromosome 12q13.3-14.1 just within the IBD2 region and is a key transcription factor involved in interleukin (IL)-4 and IL-13-mediated Th2 response. The aim of the present study was to determine distribution of the STAT6 gene polymorphism in Chinese patients with ulcerative colitis.


METHODS
The G2964A polymorphism in the 3' untranslated region of the STAT6 gene was studied in 84 unrelated Chinese patients with ulcerative colitis and 176 healthy controls by PCR and the amplification created restriction site method. The results were then compared with those from a Dutch study published previously.


RESULTS
Significant differences in genotype and allele frequencies of the STAT6 G2964A polymorphism were not found between patients with ulcerative colitis and healthy controls. Subgroups of the patients with ulcerative colitis classified according to the age at onset, sex and location of disease did not differ significantly in the distribution of this polymorphism. However, the genotypes (P < 0.0001, chi-squared = 75.332) and allele frequencies (P < 0.0001, odds ratio = 4.298, 95% confidence interval = 3.070-6.018) were significantly different between the Chinese and Dutch populations.


CONCLUSIONS
The STAT6 G2964A polymorphism is not involved in the genetic susceptibility to ulcerative colitis in Chinese patients.
Zhu
Jianbo
J
Department of Internal Medicine and Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan, China.
Xia
Bing
B
Guo
Qiusha
Q
Cheng
Hong
H
Li
Jin
J
Ye
Mei
M
Hu
Zhengguo
Z
Zhang
Xiaolian
X
Tan
Jingquan
J
D000328:Adult; D002681:China / Q000453:epidemiology; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D015995:Prevalence; D011379:Prognosis; D050800:STAT6 Transcription Factor / Q000235:genetics*
D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D004247:DNA