Semiautomated synthesis of a novel [18F] amine fluorocyanoborane for PET imaging studies. Radiosynthesis and in vivo characterization in rats.
A novel fluorine-18 labeled amine fluorocyanoborane derivative was synthesized from the bromo-derivative precursor in 22% radiochemical yield. The [18F] labeling was accomplished by a semiautomatic method that is based on the synthesis of Ag 18F from Ag2CO3 and H 18F in a platinum dish followed by sonication of the bromo-precursor with Ag 18F in dry benzene to produce [18F] labeled amine fluorocyanoborane which was used with no further purification. A total of 50 microCi of the [18F] labeled amine fluorocyanoborane was injected into normal, female Sprague-Dawley rats (250-300 g) via the tail vein and monitored by Positron emission tomography (PET)/CT to detect its biodistribution in the rat body. The images showed an uptake of this compound in the bones of rats.
Shalom
Eli
E
Department of Natural Products and Medicinal Chemistry, School of Pharmacy, Hebrew University in Jerusalem, 91120 Israel.
Takrouri
Khuloud
K
Metsuyanim
Nir
N
Grufi
Arik
A
Katzhendler
Jehoshua
J
Srebnik
Morris
M
D000818:Animals; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes; D049268:Positron-Emission Tomography; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D001896:Boron Compounds; D005462:Fluorine Radioisotopes; D000644:Quaternary Ammonium Compounds; D019275:Radiopharmaceuticals; C518967:undecyldimethylamine fluorocyanoborane