title: [Effect of Kunyining capsule on reproductive endocrine-immune functions in ovariectomized rats].
abstract: OBJECTIVE
  To study the therapeutic mechanism of Kunyining (KYN) on the climacteric syndrome and provide the pharmacodynamic basis.
  
  
  METHODS
  Ovariectomized rats were used as model to observe the effect of KYN on weight and the index of the organ of OVX rats. The concentration of E2, FSH, LH, PRL, BGP and IL-2 in serum were measured by competitive radio-immunological methods.
  
  
  RESULTS
  KYN could obviously increase the index of uterus and adrenal gland in OVX rats, and enhance the contents of E2, IL-2 and BGP. The level of FSH, LH, PRL in serum were decreased.
  
  
  CONCLUSIONS
  KYN can regulate beneficially the unbalanced reproductive endocrine-immune network, which is the pharmacological basis of KYN treating climacteric syndrome.
authors.affiliation: Zhejiang Provinical Institute of Chinese Materia Medica, Hangzhou, China. ymh702@126.com
authors.forename: Ming-hua
authors.initials: MH
authors.lastname: Yang
authors.forename: Su-bei
authors.initials: SB
authors.lastname: Yang
authors.forename: Sen
authors.initials: S
authors.lastname: Long
authors.forename: Zu-han
authors.initials: ZH
authors.lastname: Jin
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007376:Interleukin-2 / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D009929:Organ Size / Q000187:drug effects; D015675:Osteocalcin / Q000097:blood; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry; D011388:Prolactin / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000187:drug effects
chemical_list: D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D015675:Osteocalcin; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone