Spoligotype signatures in the Mycobacterium tuberculosis complex.
Evolution of the direct repeat region in Mycobacterium tuberculosis has created unique spoligotype signatures specifically associated with IS6110-defined strain families. Spoligotyping signatures may enable the analysis of the strain population structure in different settings and will enable the rapid identification of strain families that acquire drug resistance or escape protective immunity in drug and vaccine trials.
Streicher
E M
EM
DST/NRF Centre of Excellence in Biomedical TB Research, Department of Medical Biochemistry, Stellenbosch University, Tygerberg, South Africa 7505.
Victor
T C
TC
van der Spuy
G
G
Sola
C
C
Rastogi
N
N
van Helden
P D
PD
Warren
R M
RM
D015373:Bacterial Typing Techniques; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D005838:Genotype; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics*; D009841:Oligonucleotides / Q000032:analysis*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics
D004251:DNA Transposable Elements; D009841:Oligonucleotides