Severe interstitial pneumonia induced by paclitaxel in a patient with adenocarcinoma of the lung.
A 71-year-old Japanese man with adenocarcinoma of the lung developed interstitial pneumonia after treatment with paclitaxel. The patient had acute chills and fever on the fourth day after the second exposure to paclitaxel, rapidly got worse despite empiric therapies, and developed prolonged respiratory failure requiring mechanical ventilation. Four months later, he died of respiratory failure due to progression of both interstitial pneumonia and lung cancer. This is the first case developing fatal paclitaxel-induced pulmonary toxicity to date. Interstitial pneumonia should be considered one of the possible life-threatening complications during treatment with paclitaxel.
Suzaki
Noriyuki
N
Department of Respiratory Medicine, Okayama University Hospital, Okayama 700-8558, Japan.
Hiraki
Akio
A
Takigawa
Nagio
N
Ueoka
Hiroshi
H
Tanimoto
Yasushi
Y
Kozuki
Toshiyuki
T
Tabata
Masahiro
M
Kanehiro
Arihiko
A
Kiura
Katsuyuki
K
Tanimoto
Mitsune
M
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel; D008775:Methylprednisolone