The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma.
We have measured the concentrations of metabolites related to the turnover of NAD, which accumulate in the blood of children with renal failure. One is a novel nucleotide, identified as the N1-riboside triphosphate of 4-pyridone-3-carboxamide (4PYTP), also described as 4KNTP, which accumulates in the erythrocytes in parallel with renal failure.
Carrey
E A
EA
Institute of Child Health, University College London, London, UK. e.carrey@ich.ucl.ac.uk
Synesiou
E
E
Simmonds
H A
HA
Fairbanks
L D
LD
D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008297:Male; D009243:NAD / Q000378:metabolism; D009536:Niacinamide / Q000031:analogs & derivatives / Q000378:metabolism; D009711:Nucleotides / Q000097:blood* / Q000737:chemistry; D051437:Renal Insufficiency / Q000097:blood*
C516364:4-pyridone-3-carboxamide N-1 riboside triphosphate; D009711:Nucleotides; D009243:NAD; D009536:Niacinamide; D000255:Adenosine Triphosphate; C005211:N'-methyl-2-pyridone-5-carboxamide