[Vasculitis and liver disease].
Extrahepatic manifestations of liver diseases especially the hepatitis B virus (HBV)-infection and hepatitis C virus (HCV)-infection may occur during acute and/or chronic viral hepatitis. Besides a serum like illness with fever, arthralgia and urticaria, haematological disorders with transient bone marrow suppression and cryoglobulinemia have been described. Vasculitis is a rare complication of viral hepatitis. However, HCV can trigger a cryoglobulinemic vasculitis and may clinically present with purpura, arthritis, neuropathy, glomerulonephritis and fatigue. Panarteritis nodosa is frequently associated with HBV infection, which is caused by deposits of immune complexes in the arterial wall. Therapy of both types of vasculitis depends on the severity of disease and may include immunosuppressive agents as well as antivirals.
Spangenberg
H C
HC
Medizinische Universitätsklinik, Abteilung Innere Medizin II, Albert-Ludwigs-Universität Freiburg. spangenberg@ukl.uni-freiburg.de
Blum
H E
HE
D003449:Cryoglobulinemia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D003937:Diagnosis, Differential; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D010488:Polyarteritis Nodosa / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors; D014657:Vasculitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy