title: Nuclear anarchy: asynchronous mitosis in multinucleated fungal hyphae.
abstract: Multinucleated cells are found in diverse contexts and include filamentous fungi, developing insect embryos, skeletal muscle and metastasizing tumor cells. Some multinucleated cells such as those in muscles arise from cell fusion events, but many are formed through specialized cell cycles in which nuclear and cell division are uncoupled. Recent work in the fungus Ashbya gossypii illustrates how unique spatial and temporal regulation of conserved cell cycle regulators directs mitosis in multinucleated cells.
authors.affiliation: Department of Biology, Gilman Hall, Dartmouth College, Hanover, NH 03755, USA. gladfelter@dartmouth.edu
authors.forename: Amy S
authors.initials: AS
authors.lastname: Gladfelter
mesh_terms: D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism* / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005658:Fungi / Q000235:genetics / Q000502:physiology*; D025301:Hyphae / Q000254:growth & development*; D008938:Mitosis
chemical_list: D018797:Cell Cycle Proteins; D005656:Fungal Proteins