11/9-mixed helices in the alpha/beta-peptides derived from alternating alpha- and beta-amino acids with proteinogenic side chains.
alpha/beta-Hybrid peptides are prepared from amino acids with proteinogenic side chains on the basis of the concept of "alternating chirality", involving D-Phe and a beta3-hVal. Through the extensive NMR, CD, and MD studies, robust left-handed 11/9-mixed helices were identified in these peptides in CDCl3 solutions, wherein the 11/9-mixed helix was observed even in a small peptide with three residues.
Srinivasulu
Gannoju
G
Centre for Nuclear Magnetic Resonance and D-211, Discovery Laboratory, Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Kumar
Singarapu Kiran
SK
Sharma
Gangavaram V M
GV
Kunwar
Ajit C
AC
D020816:Amino Acid Motifs; D000596:Amino Acids / Q000737:chemistry*; D002942:Circular Dichroism; D003198:Computer Simulation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
D000596:Amino Acids; D010455:Peptides