Melatonin potentiates tear secretion induced by diadenosine tetraphosphate in the rabbit.
Diadenosine tetraphosphate (Ap(4)A, 0.03 nmol) applied topically to the cornea of New Zealand white rabbits, evoked an increase in tear secretion of 9.7 +/- 2.60% (N=7). Melatonin (1 nmol) had no significant effect. Application of Ap(4)A in combination with melatonin, evoked a significantly greater increase in tear secretion of 34.2 +/- 5.8% (N=11). This potentiating effect of melatonin was blocked by pretreating the cornea with a topical application of the melatonin receptor antagonist, luzindole (240 nmol). Melatonin combined with Ap(4)A may be useful for treating dry eye conditions.
Hoyle
Charles H V
CH
Institute of Medicine, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE 1410, Brunei Darussalam. choyle@im.ubd.edu.bn
Peral
Assumpta
A
Pintor
Jesús
J
D000818:Animals; D015226:Dinucleoside Phosphates / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013666:Tears / Q000378:metabolism*; D014363:Tryptamines / Q000494:pharmacology
D015226:Dinucleoside Phosphates; D014363:Tryptamines; C057154:luzindole; C020733:diadenosine tetraphosphate; D008550:Melatonin