title: Severe interstitial pneumonia induced by paclitaxel in a patient with adenocarcinoma of the lung.
abstract: A 71-year-old Japanese man with adenocarcinoma of the lung developed interstitial pneumonia after treatment with paclitaxel. The patient had acute chills and fever on the fourth day after the second exposure to paclitaxel, rapidly got worse despite empiric therapies, and developed prolonged respiratory failure requiring mechanical ventilation. Four months later, he died of respiratory failure due to progression of both interstitial pneumonia and lung cancer. This is the first case developing fatal paclitaxel-induced pulmonary toxicity to date. Interstitial pneumonia should be considered one of the possible life-threatening complications during treatment with paclitaxel.
authors.affiliation: Department of Respiratory Medicine, Okayama University Hospital, Okayama 700-8558, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Suzaki
authors.forename: Akio
authors.initials: A
authors.lastname: Hiraki
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueoka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kozuki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tabata
authors.forename: Arihiko
authors.initials: A
authors.lastname: Kanehiro
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kiura
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel; D008775:Methylprednisolone