Colorectal neoplasm and acromegaly.
The risk for colorectal carcinoma in acromegaly remains controversial. In our earlier study, we have demonstrated that the risk of colorectal carcinoma in Asian Indians with acromegaly is not increased and after this report, routine colonoscopy in our patients with acromegaly was abandoned. Subsequently, two consecutive young men aged 30 and 35, one 6 years after and other at the time of diagnosis of acromegaly had colorectal carcinoma respectively. None of them had family history of colonic neoplasm. These two younger patients with no other predisposition for colorectal neoplasm suggests that colonoscopy should be done in all patients with acromegaly at diagnosis and they should remain under surveillance.
Bhansali
Anil
A
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. anilbhansali_endocrine@rediffmail.com
Dutta
Pinaki
P
Bhat
Mohammad Hayat
MH
Sinha
S K
SK
Kochar
R
R
Vaiphi
K
K
D000172:Acromegaly / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D000236:Adenoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D000328:Adult; D001344:Autopsy; D017024:Chemotherapy, Adjuvant; D003082:Colectomy; D003111:Colonic Polyps / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome