title: Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression.
abstract: Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evidence for the activation of NF-kappaB-dependent target genes in a variety of solid tumors and hematologic malignancies. This review focuses on the mechanisms by which the NF-kappaB pathway is activated in cancer and on the oncogenic functions controlled by activated NF-kappaB. Additionally, the effects of NF-kappaB activation in tumors relative to cancer therapy are also discussed.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Bassères
authors.forename: A S
authors.initials: AS
authors.lastname: Baldwin
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D016328:NF-kappa B; D051550:I-kappa B Kinase