Common Kibra alleles are associated with human memory performance.
Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.
Papassotiropoulos
Andreas
A
Division of Psychiatry Research, University of Zurich, Zurich 8057, Switzerland. papas@bli.unizh.ch
Stephan
Dietrich A
DA
Huentelman
Matthew J
MJ
Hoerndli
Frederic J
FJ
Craig
David W
DW
Pearson
John V
JV
Huynh
Kim-Dung
KD
Brunner
Fabienne
F
Corneveaux
Jason
J
Osborne
David
D
Wollmer
M Axel
MA
Aerni
Amanda
A
Coluccia
Daniel
D
Hänggi
Jürgen
J
Mondadori
Christian R A
CR
Buchmann
Andreas
A
Reiman
Eric M
EM
Caselli
Richard J
RJ
Henke
Katharina
K
de Quervain
Dominique J-F
DJ
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000818:Animals; D001288:Attention; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D002135:Calcium-Binding Proteins / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006239:Haplotypes; D006624:Hippocampus / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008279:Magnetic Resonance Imaging; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008568:Memory; D051379:Mice; D008875:Middle Aged; D010750:Phosphoproteins; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013557:Switzerland; D014481:United States
C472551:CLSTN2 protein, human; D002135:Calcium-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins; D011506:Proteins; C513637:WWC1 protein, human