Silicon switches of marketed drugs.
The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.
Pooni
P K
PK
Paradigm Therapeutics Ltd., 418 Cambridge Science Park, Milton Road, Cambridge, CB4 0PA, UK. ppooni@paradigm-therapeutics.com
Showell
G A
GA
D004298:Dopamine / Q000737:chemistry; D015195:Drug Design; D015394:Molecular Structure; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012701:Serotonin / Q000737:chemistry; D013329:Structure-Activity Relationship
D017646:Organosilicon Compounds; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine