The price of the CD27-CD70 costimulatory axis: you can't have it all.
T cells require costimulatory signals for optimal proliferation, differentiation, and survival and thus to induce protective immune responses. Recent data, however, show that during chronic lymphocyte choriomeningitis virus (LCMV) infection, triggering of the costimulatory receptor CD27 by its ligand CD70 impedes neutralizing antibody production and leads to viral persistence. Thus, while being crucial for the induction of some adaptive effector pathways, costimulation may block the development of others. Pathogens may exploit this Achilles' heal to achieve persistence.
Nolte
Martijn A
MA
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Netherlands. m.a.nolte@amc.uva.nl
van Lier
René A W
RA
D000818:Animals; D053282:CD27 Ligand / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000502:physiology*
D053282:CD27 Ligand; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7