Comparison of a bolus of fentanyl with an infusion of alfentanil during target-controlled propofol infusion in third molar extraction under conscious sedation.
OBJECTIVE
This study was designed to compare hemodynamic changes, respiratory depression, and patient satisfaction between a bolus of fentanyl and an infusion of alfentanil during target-controlled propofol infusion in third molar extraction under conscious sedation.


METHODS
Forty patients were randomly assigned to receive either a bolus of fentanyl (n = 24) or an infusion of alfentanil (n = 16) in combination with target-controlled propofol infusion. Hemodynamic changes, respiratory depression, sedation, and cooperation scores were recorded during surgery and patient satisfaction scores were assessed after surgery.


RESULTS
Changes in mean blood pressure, heart rate, or oxygen saturation within and between the groups were not significant throughout the procedure. There were no significant differences in sedation, cooperation, and patient satisfaction scores between the 2 groups.


CONCLUSIONS
Because there was no difference in hemodynamic variables and patient satisfaction scores between a bolus of fentanyl and an infusion of alfentanil during target-controlled propofol infusion, both combinations are suitable for conscious sedation in third molar extraction.
Kwak
Hyun J
HJ
Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Korea.
Kim
Ji Y
JY
Kwak
Young L
YL
Park
Won S
WS
Lee
Kyung C
KC
D000328:Adult; D015760:Alfentanil / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000704:Analysis of Variance; D000766:Anesthesia, Dental / Q000379:methods*; D000771:Anesthesia, Intravenous / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D016009:Chi-Square Distribution; D016292:Procedural Sedation / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010100:Oxygen / Q000097:blood; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage; D011446:Prospective Studies; D012119:Respiration / Q000187:drug effects; D014081:Tooth Extraction
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D015760:Alfentanil; D010100:Oxygen; D005283:Fentanyl; D015742:Propofol