[The clinical study on chronic hepatitis B treated by the four-step therapeutics of Traditional Chinese Medicine].
OBJECTIVE
To observe the clinical curative effect of chronic hepatitis B treated by the four-step therapeutics of Traditional Chinese Medicine (TCM).


METHODS
120 patients with mild or moderate Chronic Hepatitis B (CHB) were randomly divided into two groups: 80 patients in treatment group and 40 in control group. All enrolled cases accorded with the enroll standard. In treatment group, the patients were divided into mild moderate and severe degree of immune intervention based on the ALT level and treated with four-step therapeutics according to the dialectical theory. In control group, all patients were administered 100mg Lamivudine orally daily for two years.


RESULTS
The loss rates of HBeAg, HBV-DNA, precore mutation were 58.9%, 78.9% in treatment group respectively, and 33.3%, 38.9% in control group. There were significant defferences between them. The total effectiveness ratio of two groups has no significant difference. After the treatment, the value of HA, PCIII, IV. C,LN decreased dramatically in treatment group and the antihepatic fibrosis results of treatment group were superior to those of control group. The four-step therapeutics of TCM could improve the ALT value and the ALT value declined to normal after the virus indexes' loss. The response rate in treatment group of ALT-elevating patients was higher than those of no ALT- elevating patients.


CONCLUSIONS
The four-step therapeutics of TCM is effective in treating the CHB patients.
Yang
Hong-zhi
HZ
The Third Affiliated Hopital, Sun Yat-sen University, Guangzhou, China.
Wang
Feng-lin
FL
Wang
Yong-ze
YZ
Shen
Wei-sheng
WS
Xu
Guo-liang
GL
Yang
Yue-wu
YW
Huang
Xue-lan
XL
D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D019259:Lamivudine