[Stability of busulfan injection solution (Busilvex, Busulfex) in B/Braun Injekt syringes].
Stability of busulfan injection solution (Busilvex, Busulfex) in B/Braun Injekt syringes Stability of busulfan injection was determined by a modified stability-indicating HPLC method with UV detection. Diethyldithiocarbamate was used as derivatization agent. The stability tests revealed that busulfan injection (Busilvex, Busulfex) stored in B/Braun Injekt syringes at 18-20 degrees C without light protection or refrigerated are stable for up to 28 days. Unused busulfan injection (Busilvex, Busulfex) is not necessarily to be discarded, but can be stored for a prolonged period of time in a rubber free syringe, preferably under refrigeration.
Karstens
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Apotheke des Klinikums der Johannes Gutenberg-Universität Mainz, Germany.
Krämer
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D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry*; D002066:Busulfan / Q000737:chemistry*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D004356:Drug Storage; D007202:Indicators and Reagents; D008027:Light; D019999:Pharmaceutical Solutions; D013056:Spectrophotometry, Ultraviolet; D013594:Syringes; D013696:Temperature
D018906:Antineoplastic Agents, Alkylating; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D002066:Busulfan