Polymorphisms within inflammatory genes and colorectal cancer.
BACKGROUND
Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain).


RESULTS
There was no statistically significant association between the SNPs investigated and colorectal cancer risk.


CONCLUSIONS
The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alternatively, the negative results may derive from no particular biological effect of the analysed polymorphisms in relation to CRC. Otherwise, the eventual biological effect is so little to go undetected, unless analysing a much larger sample size.
Landi
Stefano
S
Genetics-Department of Biology, University of Pisa, via S, Giuseppe 22, 56126, Pisa, Italy. slandi@biologia.unipi.it
Gemignani
Federica
F
Bottari
Fabio
F
Gioia-Patricola
Lydie
L
Guino
Elisabet
E
Cambray
María
M
Biondo
Sebastiano
S
Capella
Gabriel
G
Boldrini
Laura
L
Canzian
Federico
F
Moreno
Victor
V
D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics; D018836:Inflammation Mediators / Q000378:metabolism*; D011110:Polymorphism, Genetic
D018836:Inflammation Mediators