[Oesophageal squamous cell carcinoma stade III. State of surgery after radiochemotherapy (RCT)].
Neoadjuvant chemoradiotherapy is the gold standard of the treatment of advanced oesophageal squamous cell carcinoma. The role of surgery after chemoradiotherapy is still debated. Feasibility of curative resection depends on dose of radiotherapy, morbimortality rates, and nutrition status at the end of the protocol especially for non-responders patients. Adding surgery to radiochemotherapy improves local tumour control but does not increase overall survival of patients with advanced oesophageal squamous cell carcinoma. According to the two randomised trials published on the subject, surgery is not recommended after chemoradiotherapy for responders. Recommendations of French National Thesaurus are: exclusive chemoradiotherapy as reference, esophagectomy for residual tumour as alternative for operable patients. Surgery may be proposed for selected non-responders patients and some complete pathology response in expert center.
Triboulet
J-P
JP
Service de Chirurgie Digestive et Générale, Rez-de-Jardin-Aile-Ouest, Hôpital Claude-Huriez, Place de Verdun, 59037 Lille Cedex, France. jp-triboulet@chru-lille.fr
Mariette
C
C
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D018849:Controlled Clinical Trials as Topic; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D009367:Neoplasm Staging; D018307:Neoplasms, Squamous Cell / Q000000981:diagnostic imaging* / Q000532:radiotherapy* / Q000601:surgery; D011788:Quality of Life; D011859:Radiography; D013997:Time Factors; D016896:Treatment Outcome