title: Cadaver kidney transplantation and vascular anomalies: a pediatric experience.
abstract: BACKGROUND
  The incidence of donor kidneys with vascular anomalies ranges from 18% to 30%; such kidneys are usually at increased risk of vascular and urological complications. The aim of this study was to determine whether the use of cadaver kidneys with vascular anomalies would adversely affect posttransplant graft and patient outcome.
  
  
  METHODS
  From October 1987 to January 2004, 241 patients underwent kidney transplantation in our pediatric surgery department. Vascular anomalies were noted in 77/241 grafts (31.9%); 50 (64.9%) had multiple renal arteries and 22 (28.5%) venous anomalies. Patients were divided into three groups: Group A (1 renal artery and vein, 1 arterial and venous anastomosis [n = 161]), Group B (> 1 renal artery or vein, 1 arterial and venous anastomosis [n = 33]), and Group C (> 1 renal artery or vein, > 1 arterial and venous anastomosis [n = 47]). We compared the three groups for: patient and graft survival, incidence of posttransplant acute tubular necrosis, vascular and urological complications, postoperative mean creatinine levels, and posttransplantation hypertension.
  
  
  RESULTS
  We found no significant differences among the three groups regarding episodes of acute rejection or acute tubular necrosis. Creatinine levels reached normal levels within 30 days in all the groups without any significant differences. Furthermore, patient and graft survival were excellent (100% and 97%).
  
  
  CONCLUSIONS
  The presence of vascular anomalies and their multiple or complex repair does not represent a theoretical disadvantage even in pediatric patients. In order to maximize the quantity and quality of donor kidneys especially in pediatric population, kidneys with vascular anomalies may be implanted with very little risk.
authors.affiliation: Division of Pediatric Surgery, Department of Pediatrics, University of Padua, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: De Coppi
authors.forename: Stefano
authors.initials: S
authors.lastname: Giuliani
authors.forename: Fabio
authors.initials: F
authors.lastname: Fusaro
authors.forename: Cinzia
authors.initials: C
authors.lastname: Zanatta
authors.forename: Graziella
authors.initials: G
authors.lastname: Zacchello
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Gamba
authors.forename: Giovanni F
authors.initials: GF
authors.lastname: Zanon
mesh_terms: D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications* / Q000628:therapy*; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology