title: Synthesis and anti-inflammatory activities investigation of sinomenine derivatives on ring C.
abstract: Eighteen sinomenine derivatives on ring C were prepared, and their anti-inflammatory activities were also investigated. Most of these derivatives showed mild to moderate activities. Compounds 4a, 4c and 5b showed better anti-inflammatory activity. So further modification of the ring C in sinomenine should be worthwhile.
authors.affiliation: Department of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Tang
authors.forename: Juan
authors.initials: J
authors.lastname: Luo
authors.forename: Qianli
authors.initials: Q
authors.lastname: Zhu
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
authors.forename: Shufan
authors.initials: S
authors.lastname: Yin
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000627:therapeutic use*; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009019:Morphinans / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009019:Morphinans; C009271:sinomenine