Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease.
An intravascular catheter for Raman spectroscopic detection and analysis of coronary atherosclerotic disease has been developed. The catheter, having an outer diameter of 2 mm, consisted of a side-view-type micro-Raman probe, an imaging fiber bundle, a working channel (injection drain), and a balloon. By inflating the balloon, the probe was brought close to the inner wall of a modeled blood flow system and detected a phantom target buried in the wall. Results obtained demonstrate the possibility of using the spectroscopic catheter for molecular diagnosis of coronary lesions.
Komachi
Yuichi
Y
Tashiro Probing Technology Laboratory, RIKEN The Institute of Physical and Chemical Research, Hirosawa, Wako-shi, Saitama, Japan. komachi@riken.jp
Sato
Hidetoshi
H
Tashiro
Hideo
H
D000818:Animals; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods
D015415:Biomarkers; D001798:Blood Proteins