title: Central pancreatectomy for benign pancreatic pathology/trauma: is it a reasonable pancreas-preserving conservative surgical strategy alternative to standard major pancreatic resection?
abstract: BACKGROUND
  The aim of this study was to assess the technical feasibility, safety and outcome of central pancreatectomy (CP) with pancreaticogastrostomy or pancreaticojejunostomy in appropriately selected patients with benign central pancreatic pathology/trauma. Benign lesions/trauma of the pancreatic neck and proximal body pose an interesting surgical challenge. CP is an operation that allows resection of benign tumours located in the pancreatic isthmus that are not suitable for enucleation.
  
  
  METHODS
  Between January 2000 and December 2005, eight central pancreatectomies were carried out. There were six women and two men with a mean age of 35.7 years. The cephalic pancreatic stump is oversewn and the distal stump is anastomosed end-to-end with a Roux-en-Y jejunal loop in two and with the stomach in six patients. The indications for CP were: non-functional islet cell tumours in two patients, traumatic pancreatic neck transection in two and one each for insulinoma, solid pseudopapillary tumour, splenic artery pseudoaneurysm and pseudocyst. Pancreatic exocrine function was evaluated by a questionnaire method. Endocrine function was evaluated by blood glucose level.
  
  
  RESULTS
  Morbidity rate was 37.5% with no operative mortality. Mean postoperative hospital stay was 10.5 days. Neither of the patients developed pancreatic fistula nor required reoperations or interventional radiological procedures. At a mean follow up of 26.4 months, no patient had evidence of endocrine or exocrine pancreatic insufficiency, all the patients were alive and well without clinical and imaging evidence of disease recurrence.
  
  
  CONCLUSIONS
  When technically feasible, CP is a safe, pancreas-preserving pancreatectomy for non-enucleable benign pancreatic pathology/trauma confined to pancreatic isthmus that allows for cure of the disease without loss of substantial amount of normal pancreatic parenchyma with preservation of exocrine/endocrine function and without interruption of enteric continuity.
authors.affiliation: Department of Surgical Gastroenterology, Center for G. I. Bleed and Division of Hepato Biliary Pancreatic Diseases, Government Stanley Medical College Hospital, Chennai, India.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Johnson
authors.forename: Shanmugasundaram
authors.initials: S
authors.lastname: Rajendran
authors.forename: Tirupporur G
authors.initials: TG
authors.lastname: Balachandar
authors.forename: Devy G
authors.initials: DG
authors.lastname: Kannan
authors.forename: Satyanesan
authors.initials: S
authors.lastname: Jeswanth
authors.forename: Palaniappan
authors.initials: P
authors.lastname: Ravichandran
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Surendran
mesh_terms: D000007:Abdominal Injuries / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D000293:Adolescent; D000328:Adult; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000293:injuries; D010180:Pancreatectomy / Q000379:methods*; D010182:Pancreatic Diseases / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome