[The correlation between pregnancy specific beta-1 glycoprotein and cytokines in post-dated pregnancy].
We have simultaneously identified levels of pregnancy specific beta-1 glycoprotein (PSG) and cytokines, as well as determined correlation between them in women with post-dated pregnancy. We studied 165 women with post-dated pregnancy, aged form 20 to 37, mean age 29.0+/-7.4. According to the gestational age they have been divided into 3 groups: I group--40 (24.2%)--birth at term 41-42 weeks of pregnancy, II group--95 (57.6%)--birth at 43-44 weeks of pregnancy, III group--30 (18.2%)--birth at 43-44 weeks of pregnancy. The control group consisted of 30 patients with term pregnancy. The comparative study of characteristics of change of PSG revealed low levels of above mentioned protein in women with post-dated pregnancy. This could possibly influenced on activation of immune system of pregnant women and defended placenta from mothers' immune system Cytokines types Th-2, IL-4 and also anti-inflammatory cytokine IL-1beta were insignificantly reduced in post-dated pregnancy cases and the true value increased in concentration of IL-6. We have valued the correlation between cytokines in plasma serum and beta-1 trophoblastic glycoprotein, and revealed mean level of correlation between the PSGG, IL-1 and IL-6 values.
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D000328:Adult; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007378:Interleukins / Q000097:blood / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000503:physiopathology*; D011273:Pregnancy, Prolonged / Q000453:epidemiology* / Q000503:physiopathology*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000502:physiology*
D007378:Interleukins; D011268:Pregnancy-Specific beta 1-Glycoproteins