Differential impact of plasma triglycerides on HDL-cholesterol and HDL-apo A-I in a large cohort.
OBJECTIVE
To examine the relationship between plasma triglycerides (TG) to HDL-cholesterol (HDL-C) or HDL apo A-I.


METHODS
Bivariate and multiple linear regression analyses in a large cohort of 1886 subjects.


RESULTS
Higher plasma TG levels were associated with lower concentrations of both HDL-C and HDL-apo A-I. However, the HDL-C/HDL-apo A-I ratio was inversely correlated with plasma TG indicating that the overall composition of the HDL changed as plasma TG changed. Plasma TG levels contributed to 15.9% of the variance of the HDL-C/HDL-apo A-I ratio, whereas gender, HDL-TG, LDL-TG, body mass index and plasma apo B levels represented between 0.15% and 2.21% of this variance.


CONCLUSIONS
These results indicate that increasing levels of plasma TG result in greater reduction in HDL-C levels than in HDL-apo A-I and this might explain, at least in part, the differences that have been observed in the magnitude of the association of HDL-C versus HDL-apo A-I with the risk of cardiovascular disease.
Tremblay
André J
AJ
Lipid Research Center, CHUQ Research Center, Québec (Québec), Canada.
Sniderman
Allan D
AD
Gagné
Claude
C
Bergeron
Jean
J
Couture
Patrick
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016632:Apolipoprotein A-I / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood*
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D014280:Triglycerides