The potential clinical impact of low-level antibiotic resistance in Staphylococcus aureus.
Low-level antibiotic resistance in Staphylococcus aureus is a frequently overlooked phenomenon, usually not detected by standard susceptibility testing procedures. It represents a gateway to high-level clinically relevant resistance. Moreover, low-level resistance may be associated with increased virulence, resistance to unrelated compounds and more successful in vivo survival.
Goldstein
F
F
Hospital Saint-Joseph, 185 rue Raymond Losserand, 75014 Paris, France. fgoldstein@hopital-saint-joseph.org
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001422:Bacterial Adhesion; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D013211:Staphylococcus aureus / Q000187:drug effects*; D014774:Virulence
D000900:Anti-Bacterial Agents