Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation.
During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.
Nankoe
Sharif R
SR
Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Sever
Sanja
S
D000818:Animals; D021961:Cell Membrane Structures / Q000378:metabolism* / Q000648:ultrastructure; D002966:Clathrin / Q000378:metabolism; D022163:Clathrin-Coated Vesicles / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D034281:Dynamins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004705:Endocytosis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006835:Hydrazones / Q000494:pharmacology*; D008954:Models, Biological
D002966:Clathrin; D006835:Hydrazones; C511794:N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide; D034281:Dynamins