Platelet-rich plasma: a review of biology and applications in plastic surgery.
Healing of hard and soft tissue is mediated by a complex array of intracellular and extracellular events that are regulated by signaling proteins, a process that is, at present, incompletely understood. What is certain, however, is that platelets play a prominent if not deciding role. Controlled animal studies of soft and hard tissues have suggested that the application of autogenous platelet-rich plasma can enhance wound healing. The clinical use of platelet-rich plasma for a wide variety of applications has been reported; however, many reports are anecdotal and few include controls to definitively determine the role of platelet-rich plasma. The authors describe platelet biology and its role in wound healing; the preparation, characterization, and use of platelet-rich plasma; and those applications in plastic surgery for which it may be useful.
Eppley
Barry L
BL
Indianapolis and Warsaw, Ind.; and Chicago, Ill. From the Division of Plastic Surgery, Indiana University School of Medicine; Biomet, Inc.; and Department of Bioengineering, University of Illinois at Chicago.
Pietrzak
William S
WS
Blanton
Matthew
M
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology*; D001804:Blood Transfusion, Autologous; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D010949:Plasma / Q000502:physiology*; D015539:Platelet Activation / Q000502:physiology; D017713:Platelet Transfusion; D010982:Platelet-Derived Growth Factor; D019651:Plastic Surgery Procedures / Q000379:methods*; D014945:Wound Healing / Q000502:physiology*
D010982:Platelet-Derived Growth Factor