title: [Serum level of homocysteine and the development of collateral circulation in patients with severe coronary artery stenosis].
abstract: OBJECTIVE
  To investigate the relationship between serum level of homocysteine and the development of collaterals in patients with severe coronary artery stenosis (SCAS).
  
  
  METHODS
  Eighty patients with at least one vessel stenosis over 90% among the 3 main vessels of coronary artery were consecutively enrolled into the study according to angiographic estimation. The development of collaterals was classified by Rentrop's method.
  
  
  RESULTS
  The serum levels of homocysteine among the single-vessel, bi-vessel and tri-vessel coronary artery disease groups had no significant difference; there was no linear correlation between the serum level of homocysteine and Gensini's score. The level of homocysteine in the poorly developed collaterals was significantly higher than that in the well-developed collaterals in the SCAS patients (P<0.001). Multiple stepwise logistic analysis revealed that homocysteine negatively correlated with the development of collaterals (P<0.001, odds ratio=0.353; 95% confidence interval=0.201 - 0.620), whereas it positively correlated with the number of stenosis vessels.
  
  
  CONCLUSIONS
  The serum level of homocysteine is independently and negatively associated with the development of collateral circulation in severe SCAs patients.
authors.affiliation: Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Tian-lun
authors.initials: TL
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Chuan-chang
authors.initials: CC
authors.lastname: Li
authors.forename: Xiao-qun
authors.initials: XQ
authors.lastname: Pu
authors.forename: Zhao-fen
authors.initials: ZF
authors.lastname: Deng
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Deng
authors.forename: Shuang-yuan
authors.initials: SY
authors.lastname: Meng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003097:Collateral Circulation; D017023:Coronary Angiography; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D006711:Homocystine / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D006711:Homocystine