title: [Influence of the size and the localization of metastases in melanoma sentinel lymph nodes on the results of lymphadenectomy].
abstract: OBJECTIVE
  Thirty-five cases of lymphadenectomy carried out in the context of positive sentinel lymph node for malignant melanoma have been reviewed to assess the prognostic value of certain metastatic charachteristics. We have checked wether the type (macro or micrometastasis) and localisation (subcapsular or intraparenchymal) in the sentinel lymph node had predictive value for the lymphadenectomy outcome and evolution of the case.
  
  
  METHODS
  The retrospective study relates to 35 cases (with an average 2 years history) taken from a total of 87 sentinel lymph node protocols; average age 46.5 years, Breslow 2.5 mm with an history of 25 months.
  
  
  RESULTS
  Among the 35 positive sentinel lymph nodes we have 19 cases (54.2%) of micrometastasis. Among the 35 lymphadenectomy 5 cases (14.28%) turned out positive, 3 of which concerned micrometastatic sentinel lymph nodes. In our cohort the micrometastatic nature of sentinel lymph nodes did not have statistically significant impact upon the lymphadenectomy result but showed more favourable short-term evolution with 68.42% metastatic free evolution as against 43.75% in case of initial macrometastasis. The subcapsular localisation of micrometastasis equally represents a factor of improved prognosis (69.2% of metastatic free evolution against of 30.8% in the case of intraparenchymal localistion).
  
  
  CONCLUSIONS
  Unfortunately, none of the studied criteria justifies a modification of our present clinical attitude whereby a systematic lymphadenectomy in cases of positive sentinel lymph nodes is performed, whatever the type or localisation of the relevant metastases.
authors.affiliation: Service de chirurgie plastique, CHU Charles-Nicolle, 1, rue de Germont, 76000 Rouen, France.
authors.forename: M-H
authors.initials: MH
authors.lastname: Denis
authors.forename: E
authors.initials: E
authors.lastname: Dudrap
authors.forename: P
authors.initials: P
authors.lastname: Courville
authors.forename: I
authors.initials: I
authors.lastname: Auquit-Auckbur
authors.forename: P
authors.initials: P
authors.lastname: Joly
authors.forename: P-Y
authors.initials: PY
authors.lastname: Milliez
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology*; D016896:Treatment Outcome