[Experimental studies on antitussive, expectorant and antiasthmatic effects of extract from Citrus grandis var. tomentosa].
OBJECTIVE
To observe the antitussive, expectorant and antiashmatic effects of the extract from Citrus grandist var. tomentosa.


METHODS
The cough models induced by ammonia liquor in mice and citric acid in guines pigs were used to observe the antitussive effects. The methods of phenel red execretion in mice and phlegm displacement of rats were used to investigate the expectorant effects. Bronchial asthma model induced by histamine-acetylcholine in guinea pigs was used to observe the antiasthmatic effects.


RESULTS
The extract from the title plant could inhibit the cough induced by ammonia in mice, decrease the frequency of cough induced by citric acid in guineas pig and prolong the latent period of cough. The extract also could obviously increase phenol red output of trachea in mice, promote expectoration in rats and prolong the latent period of asthma induced by histamine-acetylcholine in guinea pigs.


CONCLUSIONS
The extract from C. grandis var. tomenfosa has significant antitussive, expectorant and antiasthmatic effects.
Li
Pei-Bo
PB
College of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Ma
Yan
Y
Wang
Yong-Gang
YG
Su
Wei-Wei
WW
D000109:Acetylcholine; D000641:Ammonia; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D000996:Antitussive Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy; D019343:Citric Acid; D002957:Citrus / Q000737:chemistry; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use; D005100:Expectorants / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D005638:Fruit / Q000737:chemistry; D006168:Guinea Pigs; D006632:Histamine; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D018927:Anti-Asthmatic Agents; D000996:Antitussive Agents; D004365:Drugs, Chinese Herbal; D005100:Expectorants; D019343:Citric Acid; D000641:Ammonia; D006632:Histamine; D000109:Acetylcholine