title: Bdellovibrio: growth and development during the predatory cycle.
abstract: Predatory Bdellovibrio enter the periplasm of other Gram-negative bacteria, growing within and consuming them. Unravelling molecular details of this intimate association between bacterial predator and prey is challenging yet fascinating, and might lead to novel antibacterials in the future. Pioneering physiological and biochemical studies described the predatory life of Bdellovibrio in the 1960s and 1970s, later followed by recombinant DNA work in the 1990s, which led to a revival in Bdellovibrio molecular research. This revival continues in the 21st century with the advent of a genome sequence. Now worldwide research is underway on the comparative genomics and transcriptomics of predatory bacteria, and will illuminate the evolutionary adaptations to become predatory, and will hopefully ultimately illuminate how the predatory processes of Bdellovibrio can be employed against pathogenic bacteria and for humankind.
authors.affiliation: Institute of Genetics, School of Biology QMC, University of Nottingham, Nottingham NG7 2UH, UK.
authors.forename: Carey
authors.initials: C
authors.lastname: Lambert
authors.forename: Karen A
authors.initials: KA
authors.lastname: Morehouse
authors.forename: Chien-Yi
authors.initials: CY
authors.lastname: Chang
authors.forename: R Elizabeth
authors.initials: RE
authors.lastname: Sockett
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology; D001501:Bdellovibrio / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D020387:Food Chain