[Onycholysis with hyponychium exudate secondary to chemotherapy with paclitaxel and capecitabine].
A 39-year-old female patient who consulted due to onycholysis, subungual hyperkeratosis and presence of exudate in the big toe of the right foot. The lesions appeared during oncology treatment of bilateral breast cancer with lymphatic metastases with paclitaxel every three weeks and capecitabine daily. Clinical manifestations are due to the involvement of the nail bed caused by the chemotherapy. These should be known and taken into account due to the increased use of this type of cytotoxic agents.
Tejera
Antonio
A
Servicio de Dermatología, Hospital Clínico Universitario Virgen de la Victoria, Málaga. España.
Bosch
Ricardo J
RJ
López
Norberto
N
Herrera
Enrique
E
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D001252:Astringents / Q000008:administration & dosage / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D000069287:Capecitabine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005122:Exudates and Transudates; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006214:Hallux; D006801:Humans; D007642:Keratosis / Q000139:chemically induced; D016712:Mupirocin / Q000008:administration & dosage / Q000627:therapeutic use; D009260:Nail Diseases / Q000139:chemically induced* / Q000188:drug therapy; D009824:Ointments; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome; D019287:Zinc Sulfate / Q000008:administration & dosage / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D001252:Astringents; D009824:Ointments; D003841:Deoxycytidine; D000069287:Capecitabine; D019287:Zinc Sulfate; D016712:Mupirocin; D017239:Paclitaxel; D005472:Fluorouracil