title: [Sodium valproate as a cause of acute pancreatitis: a case report].
abstract: Valproic acid (VPA) is a commonly used medication approved by the U.S. FDA for the treatment of epilepsy, migraines and bipolar disorders. Adverse effects associated with VPA are typically benign, but there are more serious effects that are less frequent. These effects include hepatotoxicity, teratogenicity, possible polycystic ovaries with a potential sterile effect and acute pancreatitis. Even though acute pancreatitis is an adverse effect of very low frequency, it is very important due to the high mortality rate of patients with acute pancreatitis as a consequence of the use of valproic acid. In medical literature, by 2005, 80 cases of acute pancreatitis caused by valproic acid were reported, 33 of these cases were patients under the age of 18. This is a description of the clinical case of a 16 year old patient with necrotic pancreatitis caused by VPA, who was treated at the Acute Pancreatitis Unit of Edgardo Rebagliati Martins National Hospital.
authors.affiliation: Servicio de Emergencia, Unidad de Pancreatitis Aguda, Hospital Nacional Edgardo Rebagliati Martins.
authors.forename: Luís
authors.initials: L
authors.lastname: Barreda
authors.forename: Johana
authors.initials: J
authors.lastname: Rosas
authors.forename: William
authors.initials: W
authors.lastname: Milian
authors.forename: Duilio
authors.initials: D
authors.lastname: Valdivia
authors.forename: Javier
authors.initials: J
authors.lastname: Targarona
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D001774:Blood Chemical Analysis; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid