title: Immunolocalization of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in the rat forebrain.
abstract: Immunohistochemical study was performed to determine distribution of ecto-nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) in adult rat forebrain. The study revealed widespread distribution of NPP1 in rat forebrain, yet with regional differences in the expression pattern and abundance. Strong NPP1 immunoreaction was detected in pyramidal cell layer of cerebral cortex and hippocampus, and in the midline regions of hypothalamus and thalamus. In many immunopositive forebrain areas, NPP1 was mainly localized at neuronal cell bodies. However, prominent immunoreaction was also detected at ependymal cells, tanycytes, endothelial cells of the capillaries and cells of the choroid plexus, suggesting that NPP1 could be involved in some highly specialized transport process.
authors.affiliation: Institute for Biological Research Sinisa Stankovic, Department of Neurobiology and Immunology, Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Bjelobaba
authors.forename: Nadezda
authors.initials: N
authors.lastname: Nedeljkovic
authors.forename: Sanja
authors.initials: S
authors.lastname: Subasic
authors.forename: Irena
authors.initials: I
authors.lastname: Lavrnja
authors.forename: Sanja
authors.initials: S
authors.lastname: Pekovic
authors.forename: Danijela
authors.initials: D
authors.lastname: Stojkov
authors.forename: Ljubisav
authors.initials: L
authors.lastname: Rakic
authors.forename: Mirjana
authors.initials: M
authors.lastname: Stojiljkovic
mesh_terms: D000818:Animals; D015153:Blotting, Western / Q000379:methods; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D016548:Prosencephalon / Q000378:metabolism*; D011755:Pyrophosphatases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases