title: Time spent on treatment (TSOT). An independent assessment of disease severity in atopic dermatitis.
abstract: BACKGROUND
  Time spent on treatment (TSOT) appears to reflect disease severity in pediatric patients with atopic dermatitis (AD). Our purpose was to examine the relationship between time spent on treatment and parental psychological parameters such as anxiety and depression.
  
  
  METHODS
  TSOT was studied in a group of parents of patients with AD participating in an eczema school. TSOT included all types of topical treatment. In addition, dermatological life quality (the IDLQI questionnaire), depression (the MDI questionnaire), and anxiety (the STAI questionnaire) were assessed as well as the self-reported (by parent) disease severity, treatment effect, and confidence in treatment (VAS scales) using descriptive statistics, multiple linear regression, and rank correlations (Kendall's tau).
  
  
  RESULTS
  TSOT was found to be significantly associated with parental age (older parents report lower TSOT) and IDLQI (low quality of life with high TSOT), whereas all the other parameters appeared redundant. Sex of the parent showed no effect on TSOT.
  
  
  CONCLUSIONS
  Our data suggest that TSOT is not correlated with anxiety or depression. A positive independent correlation was found with general quality of life, offering mutual validation of the measures. The observations suggest that further investigation of TSOT as a surrogate measure of morbidity in AD may be of practical interest in order to develop an internationally comparable morbidity measure in AD.
authors.affiliation: Department of Dermatology, University of Copenhagen, Roskilde Hospital, DK-4000 Roskilde, Denmark. rsgrj@ra.dk
authors.forename: Gregor B E
authors.initials: GB
authors.lastname: Jemec
authors.forename: Solveig
authors.initials: S
authors.lastname: Esmann
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Holm
authors.forename: Andreas
authors.initials: A
authors.lastname: Tycho
authors.forename: Thomas Martini Martini
authors.initials: TM
authors.lastname: Jørgensen
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000150:complications / Q000523:psychology; D002648:Child; D003866:Depressive Disorder / Q000150:complications / Q000523:psychology; D003876:Dermatitis, Atopic / Q000150:complications / Q000473:pathology / Q000523:psychology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D013997:Time Factors