title: Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV Cohort.
abstract: Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001).
authors.affiliation: Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA. Vvalcour@hawaii.edu
authors.forename: Victor
authors.initials: V
authors.lastname: Valcour
authors.forename: Priscilla
authors.initials: P
authors.lastname: Yee
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Williams
authors.forename: Bruce
authors.initials: B
authors.lastname: Shiramizu
authors.forename: Michael
authors.initials: M
authors.lastname: Watters
authors.forename: Ola
authors.initials: O
authors.lastname: Selnes
authors.forename: Robert
authors.initials: R
authors.lastname: Paul
authors.forename: Cecilia
authors.initials: C
authors.lastname: Shikuma
authors.forename: Ned
authors.initials: N
authors.lastname: Sacktor
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000523:psychology; D000375:Aging; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003072:Cognition Disorders / Q000453:epidemiology* / Q000276:immunology*; D015331:Cohort Studies; D005006:Ethnicity; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000523:psychology*; D006254:Hawaii; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016896:Treatment Outcome