HIV evolution and escape.
Human immunodeficiency virus (HIV) exemplifies the principles of Darwinian evolution with a telescoped chronology. Because of its high mutation rate and remarkably high rates of replication, evolution can be appreciated over periods of days in contrast to the durations conceived of by Darwin. Certain selective pressures that drive the evolution of HIV include chemotherapy, anatomic compartmentalization and the immune response. Examples of these selective forces on HIV evolution are described.
Richman
Douglas D
DD
Veterans Affairs San Diego Healthcare System, San Diego, CA 92161-0679, USA. drichman@ucsd.edu
Little
Susan J
SJ
Smith
Davey M
DM
Wrin
Terri
T
Petropoulos
Christos
C
Wong
Joseph K
JK
D016915:AIDS Vaccines / Q000276:immunology; D005075:Biological Evolution; D024882:Drug Resistance, Viral / Q000235:genetics; D006678:HIV / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D006801:Humans; D009154:Mutation; D012641:Selection, Genetic; D014779:Virus Replication
D016915:AIDS Vaccines