CD163-Mediated hemoglobin-heme uptake activates macrophage HO-1, providing an antiinflammatory function.
Abraham
Nader G
NG
Drummond
George
G
D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism; D019610:Cytoprotection; D004705:Endocytosis; D005293:Ferritins / Q000096:biosynthesis; D015971:Gene Expression Regulation, Enzymologic; D006418:Heme / Q000378:metabolism*; D051547:Heme Oxygenase-1 / Q000096:biosynthesis* / Q000235:genetics; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008264:Macrophages / Q000201:enzymology / Q000378:metabolism*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014158:Transcription, Genetic; D000098902:CD163 Antigen
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D006454:Hemoglobins; D018836:Inflammation Mediators; D011956:Receptors, Cell Surface; D006418:Heme; D002248:Carbon Monoxide; D005293:Ferritins; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D001663:Bilirubin