title: Seroprevalence of hepatitis B and C virus markers among blood donors in Rio de Janeiro, Brazil, 1998-2005.
abstract: The prevalence of infection by hepatitis B (HBV) and C (HCV) viruses varies among geographical regions. In order to determine the prevalence of HBV and HCV infection in voluntary blood donors we evaluated the prevalence of HBsAg, anti-HBc, and anti-HCV markers of 128,497 blood donor samples collected from 1998 to 2005 in the state of Rio de Janeiro. These markers were analyzed by immunoenzymatic tests, as determined by the Ministry of Health. Data were obtained from the Sorology Laboratory of the Hemotherapy Service of the Instituto Nacional de Câncer, Rio de Janeiro. Overall prevalence estimates were: 0.27% for HBsAg, 3.68% for anti-HBc, and 0.90% for anti-HCV. There was a significant decrease in the overall prevalence of HBsAg (from 0.36 to 0.14%) and anti-HBc (from 6.12 to 2.05%) in the period encompassed between 1998-2005. Similarly, there was a decline in anti-HCV prevalence rates in Brazilian blood donors, from 1.04% in 1998 to 0.79% in 2004, with an increase of HCV prevalence to 1.09% in 2005. These prevalence estimates were higher than those found in other countries, indicating high rates of infection by HBV and HCV and a persistent risk of HBV and HCV transmission by transfusion.
authors.affiliation: Laboratório de Sorologia, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
authors.forename: Ana F B
authors.initials: AF
authors.lastname: Andrade
authors.forename: Michelle
authors.initials: M
authors.lastname: Oliveira-Silva
authors.forename: Suely G C
authors.initials: SG
authors.lastname: Silva
authors.forename: Iara J F
authors.initials: IJ
authors.lastname: Motta
authors.forename: Cibele R
authors.initials: CR
authors.lastname: Bonvicino
mesh_terms: D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D001938:Brazil / Q000453:epidemiology; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology; D006512:Hepatitis B Core Antigens / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006526:Hepatitis C / Q000453:epidemiology* / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D015995:Prevalence; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies
chemical_list: D015415:Biomarkers; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies