title: Functional and magnetic resonance imaging correlates of corpus callosum in normal pressure hydrocephalus before and after shunting.
abstract: BACKGROUND
  Normal pressure hydrocephalus (NPH) is associated with corpus callosum abnormalities.
  
  
  OBJECTIVE
  To study the clinical and neuropsychological effect of callosal thinning in 18 patients with idiopathic NPH and to investigate the postsurgical callosal changes in 14 patients.
  
  
  METHODS
  Global corpus callosum size and seven callosal subdivisions were measured. Neuropsychological assessment included an extensive battery assessing memory, psychomotor speed, visuospatial and frontal lobe functioning.
  
  
  RESULTS
  After surgery, patients showed improvements in memory, visuospatial and frontal lobe functions, and psychomotor speed. Two frontal corpus callosum areas, the genu and the rostral body, were the regions most related to the clinical and neuropsychological dysfunction. After surgery, total corpus callosum and four of the seven subdivisions presented a significant increase in size, which was related to poorer neuropsychological and clinical outcome.
  
  
  CONCLUSIONS
  The postsurgical corpus callosum increase might be the result of decompression, re-expansion and increase of interstitial fluid, although it may also be caused by differences in shape due to cerebral reorganisation.
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Mataró
authors.forename: Mar
authors.initials: M
authors.lastname: Matarín
authors.forename: Maria Antonia
authors.initials: MA
authors.lastname: Poca
authors.forename: Roser
authors.initials: R
authors.lastname: Pueyo
authors.forename: Juan
authors.initials: J
authors.lastname: Sahuquillo
authors.forename: Maite
authors.initials: M
authors.lastname: Barrios
authors.forename: Carme
authors.initials: C
authors.lastname: Junqué
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001927:Brain Diseases / Q000209:etiology; D002557:Cerebrospinal Fluid Shunts; D003072:Cognition Disorders / Q000209:etiology; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011596:Psychomotor Disorders / Q000209:etiology