Targets of DAF-16 involved in Caenorhabditis elegans adult longevity and dauer formation.
The Forkhead Box O transcription factor DAF-16 regulates genes affecting dauer larva formation and adult life span. Expression profiling and genome-wide searches for DAF-16 binding sites in gene regulatory regions have identified thousands of potential DAF-16 targets. Some of these genes have been shown to alter longevity when their expression is attenuated by RNAi treatment. DAF-16 also associates with other transcription factors, allowing combinatorial modulation of gene expression. Although extensive descriptions of the gene network regulated by DAF-16 have been attempted, there remain many gaps in the understanding of how DAF-16 regulates dauer formation and longevity.
Jensen
Victor L
VL
Department of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Gallo
Marco
M
Riddle
Donald L
DL
D000375:Aging / Q000235:genetics*; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D051858:Forkhead Transcription Factors / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D017238:Genes, Helminth / Q000235:genetics; D007814:Larva / Q000235:genetics; D008136:Longevity / Q000235:genetics; D008957:Models, Genetic; D018510:RNA, Helminth / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D018510:RNA, Helminth; D034741:RNA, Small Interfering; D014157:Transcription Factors; C108831:daf-16 protein, C elegans