title: Current aspects of Shigella pathogenesis.
abstract: Bacillary dysentery (shigellosis) is a severe human disease caused by Shigellae. In recent years, a large amount of information has been generated regarding the host, pathogen and environmental factors that impact the pathogenesis of shigellosis at the cellular and molecular level. This review summarizes what is currently known about Shigella, detailing those factors that contribute to pathogenesis and examining the current progress in the development of a vaccine.
authors.affiliation: Department of Microbiology and Immunology, Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 77555-1070, USA. altorres@utmb.edu
authors.forename: Alfredo G
authors.initials: AG
authors.lastname: Torres
mesh_terms: D002262:Carboxy-Lyases / Q000235:genetics / Q000502:physiology; D004405:Dysentery, Bacillary / Q000382:microbiology* / Q000503:physiopathology / Q000517:prevention & control; D004777:Environment; D004847:Epithelial Cells / Q000382:microbiology; D005798:Genes, Bacterial; D044404:Genomic Islands / Q000235:genetics; D006801:Humans; D007501:Iron / Q000378:metabolism; D010957:Plasmids / Q000235:genetics; D022621:Shiga Toxin / Q000378:metabolism; D012760:Shigella / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D022281:Shigella Vaccines; D014617:Vacuoles / Q000382:microbiology; D014774:Virulence
chemical_list: D022281:Shigella Vaccines; D022621:Shiga Toxin; D007501:Iron; D002262:Carboxy-Lyases; C021520:lysine decarboxylase