Significant loss of primordial follicles after prolonged gonadotropin stimulation in xenografts of cryopreserved human ovarian tissue in severe combined immunodeficient mice.
This study evaluated the effect of gonadotropin stimulation on the primordial follicle reserve of cryopreserved human ovarian tissue after transplantation in severe combined immunodeficient mice. We found that prolonged gonadotropin stimulation significantly reduces primordial follicles.
Maltaris
Theodoros
T
Department of Obstetrics and Gynaecology, University Hospital Erlangen, Erlangen, Germany.
Beckmann
Matthias W
MW
Mueller
Andreas
A
Hoffmann
Inge
I
Kohl
Joachim
J
Dittrich
Ralf
R
D000818:Animals; D015925:Cryopreservation / Q000379:methods*; D005260:Female; D006062:Gonadotropins / Q000008:administration & dosage*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D006080:Ovarian Follicle / Q000166:cytology* / Q000187:drug effects* / Q000637:transplantation; D010062:Ovulation Induction / Q000379:methods*; D014183:Transplantation, Heterologous / Q000379:methods
D006062:Gonadotropins