Domino Heck-C-H activation reaction of unsymmetrically substituted [3]cumulene.
The Heck reaction of an unsymmetrically substituted [3]cumulene has been investigated. Although a carbonyl conjugated alkene is present, the arylpalladium species selectively inserts into the C3-4 double bond, and a subsequent C-H activation reaction with a neighboring phenyl group gives the indene derivatives with a tetrasubstituted olefin moiety.
Furuta
Takumi
T
Department of Synthetic Organic & Medicinal Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. furuta@u-shizuoka-ken.ac.jp
Asakawa
Tomohiro
T
Iinuma
Mie
M
Fujii
Satoshi
S
Tanaka
Kiyoshi
K
Kan
Toshiyuki
T