Electrochemistry of copper complexes with macrocyclic polyamines containing pyrazole units.
The voltammetric behaviour of bi- and mono-nuclear complexes formed in solution by Cu(2+) with three polyazacyclophanes containing pyrazole units in aqueous solution is described. Cyclic and square wave voltammetric responses at glassy carbon electrodes indicate that the reduction of copper-macrocycle complexes in solution takes place in two successive one-electron per Cu transfer processes coupled with preorganization and protonation reactions that mimic the behaviour of superoxide dismutase. The electrochemistry of ternary Cu(2+)-receptor-dopamine complexes exhibits significant differences with respect to the protection of the neurotransmitter from post-electron transfer cyclization reactions.
Doménech
Antonio
A
Departmento de Química Analítica, Universidad de Valencia, Dr. Moliner, 50, 46100 Burjasot, Valencia, Spain. antonio.domenech@uv.es
García-España
Enrique
E
Navarro
Pilar
P
Miranda
Carlos
C
D003300:Copper / Q000737:chemistry*; D004298:Dopamine / Q000737:chemistry; D004563:Electrochemistry; D047028:Macrocyclic Compounds / Q000737:chemistry; D018716:Molecular Mimicry; D009942:Organometallic Compounds / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D013482:Superoxide Dismutase
D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D011073:Polyamines; D011720:Pyrazoles; C031280:pyrazole; D003300:Copper; D013482:Superoxide Dismutase; D004298:Dopamine