title: Resolution of early stage diabetic nephropathy in an obese diabetic patient after gastric bypass.
abstract: Epidemiological studies have proven that obesity is a significant risk factor for type 2 diabetes. Long-term progression of diabetes leads to various microvascular complications, of which diabetic nephropathy has become of increasing importance, and is the main cause of end-stage renal failure in occidental countries. Microalbuminuria is the first marker of incipient diabetic nephropathy, an early stage glomerulopathy which can progress to renal failure and which historically has been treated with angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor antagonists. We report a severely obese diabetic patient on treatment for diabetic nephropathy with ACE-inhibitors and poor results, which resolved after Roux-en-Y gastric bypass.
authors.affiliation: Digestive Surgery Department, Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pérez
authors.forename: Nicolás
authors.initials: N
authors.lastname: Devaud
authors.forename: Alex
authors.initials: A
authors.lastname: Escalona
authors.forename: Patricio
authors.initials: P
authors.lastname: Downey
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D015992:Body Mass Index; D015897:Comorbidity; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000453:epidemiology*; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000601:surgery*; D011184:Postoperative Period; D017211:Treatment Failure
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril