title: Clinical analysis of synchronous primary neoplasms of the female reproductive tract.
abstract: OBJECTIVE
  In this study, a histopathologic review of synchronous primary neoplasms including gynecologic malignancies is presented, and the possible correlation among discrete tumor subsets, natural history, and survival is evaluated.
  
  
  METHODS
  Between the years 2000 and 2005, 20 patients suffering from synchronous primary cancers of gynecologic malignancy were identified. Clinical and pathologic information was obtained from medical records. Kaplan-Meier survival analyses were conducted.
  
  
  RESULTS
  Patients with synchronous primary malignancies constituted 0.63% of all genital malignancies. The most frequently observed synchronous neoplasm was ovarian cancer coexistent with endometrial cancer (40%). The mean age of patients suffering from synchronous ovarian and endometrial cancer was 45.2 years. All patients with synchronous primary genital malignancies underwent hysterectomy with bilateral salpingo-oophorectomy and/or adjuvant therapy. The mean duration of survival was 57 months (S.E.: 10.0; 95% confidence interval: 37-77).
  
  
  CONCLUSIONS
  Patients suffering from primary genital malignancies are sometimes co-afflicted with other primary cancers. Synchronous ovarian and endometrial cancer constitutes the most common of these cases, and is detected at a relatively early age, with generally favorable prognoses.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Kangnam St. Mary's Hospital, Seoul 137-040, Republic of Korea.
authors.forename: Seo-Yun
authors.initials: SY
authors.lastname: Tong
authors.forename: Yong-Sek
authors.initials: YS
authors.lastname: Lee
authors.forename: Jong-Sup
authors.initials: JS
authors.lastname: Park
authors.forename: Seog-Nyeon
authors.initials: SN
authors.lastname: Bae
authors.forename: Jun-Mo
authors.initials: JM
authors.lastname: Lee
authors.forename: Seung-Eun
authors.initials: SE
authors.lastname: Namkoong
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000628:therapy; D000328:Adult; D017677:Age Distribution; D018269:Carcinoma, Endometrioid / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000401:mortality / Q000628:therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000401:mortality / Q000628:therapy; D006801:Humans; D007044:Hysterectomy; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000401:mortality / Q000628:therapy; D010051:Ovarian Neoplasms / Q000401:mortality / Q000628:therapy; D011379:Prognosis