title: [The relationship between expression of interleukin-8 and prognosis of breast cancer].
abstract: OBJECTIVE
  To investigate the expression of interleukin-8 (IL-8) and its prognostic significance in breast cancer.
  
  
  METHODS
  Expression of IL-8 in 113 breast cancers, 19 breast benign tumors and 20 breast normal tissues was examined by tissue microarray using immunohistochemistry, and the association of IL-8 expression with patient's clinico-pathological characteristics and prognosis was further analyzed.
  
  
  RESULTS
  The positive rate of IL-8 expression in breast cancer was 27.4%, which was significantly higher than that in benign tumor and normal tissue of breast (P = 0.002). IL-8 expression related to histological type (P = 0.040) and lymph node status (P = 0.021). The expression of IL-8 was observed to correlate negatively with ER and PR status (P = 0.015 and P = 0.034), and correlate positively with C-erbB-2 status (P = 0.002). In addition, Kaplan-Meier curves of disease-free survival analysis showed a significant difference between IL-8 positive groups and negative group (P = 0.031).
  
  
  CONCLUSIONS
  IL-8 might be a poor prognostic factor for human breast cancer, and also might be a novel molecular marker to predicate the occurrence and progression of breast cancer.
authors.affiliation: Center of Breast Disease, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yao
authors.forename: Shen-ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.forename: Hui-xi
authors.initials: HX
authors.lastname: Wu
authors.forename: Dong-ying
authors.initials: DY
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000096:biosynthesis*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis
chemical_list: D016209:Interleukin-8; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone