Goitrous congenital hypothyroidism in a twin pregnancy causing respiratory obstruction at birth: implications for management.
We report a twin pregnancy complicated by fetal goitrous hypothyroidism secondary to dyshormonogenesis caused by thyroglobulin deficiency. Antenatal treatment with intra-amniotic thyroxine was considered but not performed, given the late gestational age at diagnosis and the multiple nature of the pregnancy. Both twins developed airway obstruction at delivery, requiring intubation and ventilation. We review the literature and describe the practical issues relating to the antenatal assessment and perinatal management of fetal goitre.
Reynolds
Ben Christopher
BC
Yorkhill Division, Queen Mother's Hospital, Glasgow, UK. pinkdoc@doctors.net.uk
Simpson
Judith Helen
JH
Macara
Lena
L
Watt
Andrew James Bruce
AJ
Kubba
Haytham
H
Donaldson
Malcolm David Cairns
MD
Pohlen
Joachim
J
D000402:Airway Obstruction / Q000209:etiology / Q000628:therapy; D003409:Congenital Hypothyroidism / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D036861:Delivery, Obstetric; D004200:Diseases in Twins; D005260:Female; D006042:Goiter / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013954:Thyroglobulin / Q000172:deficiency
D013954:Thyroglobulin