A module map showing interaction between apolipoprotein E and phospholipase A2 polymorphism in lipid profiles.
OBJECTIVE
Establish a possible conceptual relationship among Apo E and PLA2 polymorphism and lipid profiles.


METHODS
Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E and PLA2 polymorphisms and lipid profiles. Two hundred fifty-six participants agreed to have venous blood drawn for DNA studies.


RESULTS
By multiple linear regression, the PLA2 A2 allele showed a statistically significant influence on LDL-C (p = 0.0097), and the Apo epsilon2 allele showed a statistically significant influence on HDL-C (p = 0.0004), however, the interaction between the PLA2 A2 allele and the Apo epsilon2 allele was found to be significant in the blood fraction of HDL-C (p = 0.0388) and LDL-C (p = 0.0002). Decreasing HDL-C and increasing LDL-C were found when the PLA2 A2 and Apo epsilon2 allele co-existed.


CONCLUSIONS
The presence of a physiologic balance contributes significantly to homeostatic and compensatory responses regulating blood HDL-C and LDL-C profiles. A module map of the generation-control cycle and conditional activity among Apo E, PLA2, and lipid levels is presented, and both behaviours and biological perspectives under the consilience model may suggest a new approach to many kinds of complex disorders.
Lung
For-Wey
FW
Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan. forwey@seed.net.tw
Kao
Wei-Tsung
WT
Shu
Bih-Ching
BC
Yen
Yung-Chieh
YC
Tzeng
Dong-Sheng
DS
D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D003710:Demography; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood* / Q000235:genetics; D008297:Male; D008954:Models, Biological; D010741:Phospholipases A / Q000235:genetics* / Q000378:metabolism; D054467:Phospholipases A2; D011110:Polymorphism, Genetic; D013624:Taiwan
D001057:Apolipoproteins E; D008055:Lipids; D010741:Phospholipases A; D054467:Phospholipases A2