title: [Antioxidant supplements and risk of hypertension in the SU.VI.MAX trial: relationship to plasma antioxidants].
abstract: The object of this work was to determine the risk of hypertension after 6.5 years'- follow-up of supplementation in vitamins and antioxidant minerals at nutritional doses in the SU.VI.MAX trial. The authors also studied the association with plasma concentrations of antioxidants at inclusion and at long term. This was a randomised nutritional primary prevention study including 5086 adults of the SU.VI.MAX trial. After 6.5 years' follow-up, no effect of supplementation on the risk of developing hypertension could be shown compared with the placebo group: odds ratios (OR IC 95%): 1.04 (0.87-1.23) in men and 1.10 (0.95-1.29) in women. Besides, in the male 2nd and 3rd tertiles of serum beta-carotene levels at inclusion the risk of hypertension was lower [multivariate OR: 0.70 (0.44-1.12) and 0.53 (0.33-0.86) for placebo, and 0.59 (0.37-0.94) and 0.67 (0.42-1.07) for the supplemented groups]. The authors conclude that, despite a reverse relationship in men between the plasma concentrations of beta-carotene and the risk of hypertension, supplementation in antioxidants at nutritional doses had no effect on the risk of developing hypertension after 6.5 years' follow-up.
authors.affiliation: UMR (INSERM/INRA/CNAM), CRNH IdF, Bobigny Université, Paris. sebastien.czernichow@htd.aphp.fr
authors.forename: S
authors.initials: S
authors.lastname: Czernichow
authors.forename: S
authors.initials: S
authors.lastname: Bertrais
authors.forename: J
authors.initials: J
authors.lastname: Blacher
authors.forename: P
authors.initials: P
authors.lastname: Galan
authors.forename: S
authors.initials: S
authors.lastname: Briançon
authors.forename: A
authors.initials: A
authors.lastname: Favier
authors.forename: M
authors.initials: M
authors.lastname: Safar
authors.forename: S
authors.initials: S
authors.lastname: Hercberg
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D019207:beta Carotene