Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.
Crude extracts of the marine hydroid Garveia annulata show potent inhibition of indoleamine 2,3-dioxygenase (IDO). Fractionation of the extract led to the identification of the new polyketides annulin C (1), 2-hydroxygarveatin E (4), garveatin E (5), and garvin C (9). Annulins A (2), B (3), and C (1) were found to be submicromolar inhibitors of IDO.
Pereira
Alban
A
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z1.
Vottero
Eduardo
E
Roberge
Michel
M
Mauk
A Grant
AG
Andersen
Raymond J
RJ
D000818:Animals; D006801:Humans; D037402:Hydrozoa / Q000737:chemistry*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D018942:Macrolides; D009285:Naphthoquinones; D011753:Pyrones; C529393:annulin B