Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Proteomics approaches to the systems biology of cardiovascular diseases.
Proteins play a central role in a systems view of biologic processes. This review provides an overview of proteomics from a systems perspective. We survey the key tools and methodologies used, present examples of how these are currently being used in the systems biology context, and discuss future directions.
Drake
Thomas A
TA
Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA. tdrake@mednet.ucla.edu
Ping
Peipei
P
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002318:Cardiovascular Diseases / Q000235:genetics*; D002319:Cardiovascular System; D006801:Humans; D020543:Proteome; D040901:Proteomics / Q000379:methods; D013347:Subcellular Fractions / Q000648:ultrastructure; D049490:Systems Biology / Q000379:methods / Q000639:trends
D015415:Biomarkers; D020543:Proteome