[Study on application of activated carbon in paclitaxel injection].
OBJECTIVE
To inspect the effect of activated carbon with different dosage and temperature on quality of paclitaxel injection.


METHODS
Determinations in WS1-(X-026)-2001Z-paclitaxel injection were refered to compare the effect of different dosage and temperature for activated carbon on the taxol content, related material, clarity and bacterial endotoxin.


RESULTS
When used with 0.25% and 35 degrees C, activated carbon will ensure the quality of paclitaxel injection.


CONCLUSIONS
0.25% and 35 degrees C are the best condition when activated carbon is used in paclitaxel injection.
Liu
Li
L
Southern Medical University, College of Traditional Chinese Medicine, Key Laboratory of Reasearch of Traditional Chinese Medicine and New Drug, Guangzhou, China.
Luo
Jia-bo
JB
Xing
Xue-feng
XF
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002606:Charcoal / Q000008:administration & dosage* / Q000032:analysis; D004339:Drug Compounding / Q000379:methods; D007267:Injections; D017239:Paclitaxel / Q000008:administration & dosage*; D011786:Quality Control; D013696:Temperature
D000972:Antineoplastic Agents, Phytogenic; D002606:Charcoal; D017239:Paclitaxel