title: Systemic AA-amyloidosis related to MPO-ANCA microscopic polyangiitis: a case report.
abstract: We report autopsy findings in an 83-year-old woman with myeloperoxidase-type anti-neutrophil cytoplasmic antibody (MPO-ANCA)-positive microscopic polyangiitis and systemic AA amyloidosis. With a diagnosis of MPO-ANCA-related microscopic polyangiitis, the patient was treated with corticosteroids, but she died of intractable enteritis. Autopsy showed inactive vasculitis affecting small arteries in kidney, lung, intestinal tract, and skeletal muscle. Gastrointestinal viscera were thickened, and AA-amyloid was demonstrated in arterioles and surrounding tissues. Amyloidosis also involved heart, kidney, gallbladder, pancreas, salivary gland, and subcutis. ANCA-positive microscopic polyangiitis appears to have been the likely cause of this patient's AA-amyloidosis.
authors.affiliation: Nephrology Center, Toranomon Hospital, Tokyo, Japan. ubara@toranomon.gr.jp
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ubara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tagami
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suwabe
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sogawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Hoshino
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Higa
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nomura
authors.forename: Naoki
authors.initials: N
authors.lastname: Sawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Katori
authors.forename: Fumi
authors.initials: F
authors.lastname: Takemoto
authors.forename: Shigeko
authors.initials: S
authors.lastname: Hara
authors.forename: Tomoji
authors.initials: T
authors.lastname: Watanabe
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ohashi
authors.forename: Kenmei
authors.initials: K
authors.lastname: Takaichi
mesh_terms: D000369:Aged, 80 and over; D000686:Amyloidosis / Q000473:pathology / Q000503:physiopathology*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D009195:Peroxidase / Q000276:immunology*; D014657:Vasculitis / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase