title: [Studies on the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines].
abstract: OBJECTIVE
  To study the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines.
  
  
  METHODS
  The drug concentration by in situ perfusion in rats were determined by HPLC.
  
  
  RESULTS
  The hourly absorption percentages of baicalin in stomach, small intestine and colon were 8.05%, - 0.94% and 2.32%, respectively, and baioalein with 34.53%, 30.61% and 4.89%, respectively. The absorption rate constants of baicalein were 0.090 7, 0.083 7, 0.076 6 and 0.048 3, respectively in duodenum, jejunum, ileum and colon.
  
  
  CONCLUSIONS
  Baicalin is moderately absorbed in stomach and poorly in small intestine and colon; Baicalein is well absorbed in stomach and small intestine but worse in colon, suggesting that the former is more suitable to be administered orally. The extensive absorption segments of bacailein suggests that it can be processed into a sustained-release preparation.
authors.affiliation: West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Tai-ming
authors.initials: TM
authors.lastname: Liu
authors.forename: Xue-hua
authors.initials: XH
authors.lastname: Jiang
mesh_terms: D000818:Animals; D003106:Colon / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D044950:Flavanones / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005419:Flavonoids / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D031363:Scutellaria / Q000737:chemistry
chemical_list: D044950:Flavanones; D005419:Flavonoids; C038044:baicalin; C006680:baicalein