title: Osteo-odonto-keratoprosthesis: a human model of autotransplant.
abstract: We evaluated the microscopical changes that occurred when bone and dental tissue were exposed to such a foreign environment as the ocular surface and anterior chamber in 17 osteo-odonto-keratoprostheses removed from the recipient's eye after 1 to 20 years. Histochemical methods were performed to demonstrate elastic and precursor fibers, while immunohistochemical procedures were used to study the distribution of collagen types I to VI. Islands of heterotopic, newly formed bone were observed in the dentin and the periodontal space, leading to focal dentoalveolar ankylosis. Remodelling and disappearance of the periodontal ligament was never diffuse.
authors.affiliation: Department of Experimental Medicine and Pathology, University La Sapienza, Roma, Italy. irene.pecorella@uniroma1.it
authors.forename: Irene
authors.initials: I
authors.lastname: Pecorella
authors.forename: Maurizio
authors.initials: M
authors.lastname: Taloni
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciardi
authors.forename: Robert A
authors.initials: RA
authors.lastname: Alexander
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Falcinelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000539:Alveolar Process / Q000378:metabolism / Q000473:pathology* / Q000637:transplantation; D016723:Bone Remodeling; D002648:Child; D003094:Collagen / Q000378:metabolism; D003316:Corneal Diseases / Q000601:surgery*; D020878:Device Removal; D005109:Extracellular Matrix; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D019736:Prostheses and Implants; D011474:Prosthesis Design; D014092:Tooth Root / Q000378:metabolism / Q000473:pathology* / Q000637:transplantation; D014182:Transplantation, Autologous / Q000473:pathology*
chemical_list: D003094:Collagen