title: An O(N2) algorithm for discovering optimal Boolean pattern pairs.
abstract: We consider the problem of finding the optimal combination of string patterns, which characterizes a given set of strings that have a numeric attribute value assigned to each string. Pattern combinations are scored based on the correlation between their occurrences in the strings and the numeric attribute values. The aim is to find the combination of patterns which is best with respect to an appropriate scoring function. We present an O(N2) time algorithm for finding the optimal pair of substring patterns combined with Boolean functions, where N is the total length of the sequences. The algorithm looks for all possible Boolean combinations of the patterns, e.g., patterns of the form p and not q, which indicates that the pattern pair is considered to occur in a given string s, if p occurs in s, AND q does NOT occur in s. An efficient implementation using suffix arrays is presented, and we further show that the algorithm can be adapted to find the best k-pattern Boolean combination in O(Nk) time. The algorithm is applied to mRNA sequence data sets of moderate size combined with their turnover rates for the purpose of finding regulatory elements that cooperate, complement, or compete with each other in enhancing and/or silencing mRNA decay.
authors.affiliation: Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. bannai@ims.u-tokyo.ac.jp
authors.forename: Hideo
authors.initials: H
authors.lastname: Bannai
authors.forename: Heikki
authors.initials: H
authors.lastname: Hyyrö
authors.forename: Ayumi
authors.initials: A
authors.lastname: Shinohara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takeda
authors.forename: Kenta
authors.initials: K
authors.lastname: Nakai
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyano
mesh_terms: D020413:3' Untranslated Regions; D000465:Algorithms; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D004247:DNA / Q000235:genetics*; D005800:Genes, Fungal; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D010363:Pattern Recognition, Automated; D012333:RNA, Messenger / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software
chemical_list: D020413:3' Untranslated Regions; D012333:RNA, Messenger; D004247:DNA