title: Patterns of primary antiretroviral drug resistance in antiretroviral-naive HIV-1-infected individuals in a midwest university clinic.
abstract: A total of 192 HIV-1-infected antiretroviral-naive individuals had genotyping performed in our midwest university clinic between 2003 and 2005. The overall prevalence of resistance with either a reverse transcriptase or major protease mutation was 18%. There did not seem to be a significant difference in primary resistance patterns between different modes of HIV transmission (heterosexual versus men who have sex with men), gender or between white and African-American individuals.
authors.affiliation: Washington University School of Medicine, St Louis, Missouri, USA.
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Grubb
authors.forename: Ekachai
authors.initials: E
authors.lastname: Singhatiraj
authors.forename: Kristin
authors.initials: K
authors.lastname: Mondy
authors.forename: William G
authors.initials: WG
authors.lastname: Powderly
authors.forename: Edgar T
authors.initials: ET
authors.lastname: Overton
mesh_terms: D000328:Adult; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission / Q000821:virology; D016333:HIV Protease / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012194:RNA-Directed DNA Polymerase / Q000235:genetics; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D012194:RNA-Directed DNA Polymerase; D016333:HIV Protease