HIV infection of non-dividing cells: a divisive problem.
Understanding how lentiviruses can infect terminally differentiated, non-dividing cells has proven a very complex and controversial problem. It is, however, a problem worth investigating, for it is central to HIV-1 transmission and AIDS pathogenesis. Here I shall attempt to summarise what is our current understanding for HIV-1 infection of non-dividing cells. In some cases I shall also attempt to make sense of controversies in the field and advance one or two modest proposals.
Fassati
Ariberto
A
Wohl Virion Centre and MRC-UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK. a.fassati@ucl.ac.uk
D021581:Active Transport, Cell Nucleus; D000818:Animals; D002213:Capsid / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000378:metabolism; D015497:HIV-1 / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D007399:Interphase; D009698:Nucleoproteins / Q000378:metabolism*
D009698:Nucleoproteins; D054303:HIV Reverse Transcriptase