title: Effect of fowl adenovirus-1 (IBH isolate) on humoral and cellular immune competency of broiler chicks.
abstract: Fowl adenovirus-1 (FAV-1), isolated from field outbreaks of inclusion body hepatitis (IBH), was administered orally to 3-week-old disease-free broiler chicks. Humoral immune competency was evaluated by determining the antibody response of infected chicks to sheep red blood cells (SRBC) and Brucella abortus. FAV-1 infection significantly decreased the antibody response of chicks to B. abortus (T-cell-independent antigen) by decreasing IgM responses, however, the decreased antibody response to SRBC (T-cell-dependent antigen) was statistically non-significant. Bursal index was also found lowered in infected chicks as compared to the control chicks. A significant decrease was seen in blastogenesis response of peripheral blood lymphocytes to phytohaemagglutinin (PHA-P) in FAV-1-infected chicks on 2 and 3 weeks post-infection (WPI). These results indicated that FAV-1 affects humoral as well as cellular immune competency of infected chicks.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 141 004, India. amarjitsingh@gmx.net
authors.forename: Amarjit
authors.initials: A
authors.lastname: Singh
authors.forename: G S
authors.initials: GS
authors.lastname: Grewal
authors.forename: N K
authors.initials: NK
authors.lastname: Maiti
authors.forename: M S
authors.initials: MS
authors.lastname: Oberoi
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology; D002003:Brucella abortus / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D025681:Fowl adenovirus A / Q000276:immunology*; D006524:Hepatitis, Viral, Animal / Q000821:virology; D007111:Immunity, Cellular / Q000276:immunology*; D007165:Immunosuppression Therapy; D007181:Inclusion Bodies, Viral; D012756:Sheep / Q000097:blood
chemical_list: D000942:Antigens, Bacterial