Protein tyrosine phosphatases: from genes, to function, to disease.
The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.
Tonks
Nicholas K
NK
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA. tonks@cshl.edu
D001665:Binding Sites; D005786:Gene Expression Regulation; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D009369:Neoplasms / Q000201:enzymology* / Q000209:etiology; D010084:Oxidation-Reduction; D017027:Protein Tyrosine Phosphatases / Q000145:classification / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology*; D014443:Tyrosine / Q000378:metabolism
D008024:Ligands; D025521:Tumor Suppressor Proteins; D014443:Tyrosine; D017027:Protein Tyrosine Phosphatases