Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia.
BACKGROUND
Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizophrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and function of the hippocampus. Because positive symptoms in SZ have also been associated with hippocampal structure and function, we hypothesized that variation in a DISC1 haplotype containing Ser704Cys would be significantly associated with positive symptomatology in SZ.


METHODS
We tested for an association between variation in a haplotype block within the DISC1 gene containing Ser704Cys and lifetime history of positive symptoms in 199 Caucasian patients with SZ.


RESULTS
We detected significant associations between a DISC1 haplotype containing Ser704Cys and Ser704Cys genotype and lifetime severity of delusions in SZ.


CONCLUSIONS
These data suggest that that the effect of DISC1 genetic variation might be associated with positive symptoms in patients with SZ.
DeRosse
Pamela
P
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA. pderosse@lij.edu
Hodgkinson
Colin A
CA
Lencz
Todd
T
Burdick
Katherine E
KE
Kane
John M
JM
Goldman
David
D
Malhotra
Anil K
AK
D003545:Cysteine / Q000235:genetics; D003702:Delusions / Q000175:diagnosis / Q000235:genetics*; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006212:Hallucinations / Q000175:diagnosis / Q000235:genetics*; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012694:Serine / Q000235:genetics
C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins; D012694:Serine; D003545:Cysteine