Quantitative trait loci modulate vertebral morphology and mechanical properties in a population of 18-month-old genetically heterogeneous mice.
The aim of this study was to examine effects of polymorphic genes on vertebral bone morphology and mechanical properties. Genotypes from 525 18-month-old female mice were compared to geometric traits obtained from micro-computed tomography and mechanical properties from compression testing. Genetic markers were associated with traits on at least 13 different chromosomes, demonstrating the complexity of genetic control over vertebral form, function and aging.
Reeves
Grant M
GM
Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48109-2200, USA.
McCreadie
Barbara R
BR
Chen
Shu
S
Galecki
Andrzej T
AT
Burke
David T
DT
Miller
Richard A
RA
Goldstein
Steven A
SA
D000375:Aging; D000818:Animals; D001696:Biomechanical Phenomena; D033481:Chromosomes, Mammalian / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D040641:Quantitative Trait Loci; D013131:Spine / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
D005819:Genetic Markers