[Clinical study on effect of ganneng dripping pill in treating chronic hepatitis B].
OBJECTIVE
To observe the antiviral efficacy of Ganneng Dripping Pill (GDP) in treating patients with chronic hepatitis B.


METHODS
Eighty-four patients of chronic hepatitis B with positive HBV-DNA, HBsAg, and HBeAg were randomly assigned to 2 groups, the treated group (56 patients) treated with GDP and the control group (28 patients) treated with lamivudine. The therapeutic course for both groups was 6 months. The negative conversion rate of HBeAg and HBV-DNA, changes of liver function, symptoms and physical signs in patients were observed before and after treatment.


RESULTS
In the treated group, the negative conversion rate of HBV-DNA and HBeAg was 54.0% (27/50) and 30.0% (15/50) respectively, and the ALT normalizing rate was 80.0% (40/50), while those were 67.86% (19/28), 21.8% (6/28) and 75.0% (21/28) respectively in the control group, showing no significant difference between the two groups (all P > 0.05). However, the AST normalizing rate was 97.96% (48/49) in the treated group, higher than that in the control group (48.0%, 12/25, P < 0.01); and the clinical symptoms, especially the poor appetite, lassitude, gastric distention and yellow urine, were improved more significantly in the treated group than those in the control group (P <0.05 or P < 0.01).


CONCLUSIONS
GDP has a favorable short-term effect on chronic hepatitis B, it could effectively inhibit HBV replication and improve the liver function, symptoms and signs in patients.
Li
Li
L
The Seventh Department of Infection, 302 Hosipital of PLA, Beijing.
Yuan
Hai-long
HL
Wu
Qin
Q
D000328:Adult; D004279:DNA, Viral / Q000096:biosynthesis; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D016896:Treatment Outcome; D014779:Virus Replication / Q000187:drug effects*
D004279:DNA, Viral; D004365:Drugs, Chinese Herbal