Modified 'Joyce model' of opioid dependence/withdrawal.
By comprehensive and detailed measurement of the time course of withdrawal signs in rats, Joyce et al. (J. Theo. Biol. 240:531-537, 2006) recently provided a creative quantitative model of the onset of drug dependence based on the requirement of protein synthesis. Because the initial model fit the data imperfectly over the full time course, those authors postulated that additional features would be needed. We report excellent fit of the data (R(2)=0.96) by adding: (1) a transient early phase, and (2) a delay in the buildup of protein.
Raffa
Robert B
RB
Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Philadelphia PA 19140, USA. robert.raffa@temple.edu
Tallarida
Ronald J
RJ
D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D000818:Animals; D007700:Kinetics; D008954:Models, Biological; D009020:Morphine / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D009021:Morphine Dependence / Q000378:metabolism*; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D017711:Nonlinear Dynamics; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D013997:Time Factors
D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine