Can luteal regression be reversed?
The corpus luteum is an endocrine gland whose limited lifespan is hormonally programmed. This debate article summarizes findings of our research group that challenge the principle that the end of function of the corpus luteum or luteal regression, once triggered, cannot be reversed. Overturning luteal regression by pharmacological manipulations may be of critical significance in designing strategies to improve fertility efficacy.
Telleria
Carlos M
CM
Division of Basic Biomedical Sciences, Sanford School of Medicine of The University of South Dakota, Vermillion, SD 57069, USA. carlos.telleria@usd.edu
D000735:Androstenedione / Q000494:pharmacology; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007986:Luteinizing Hormone / Q000494:pharmacology; D003341:Luteolysis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism; D011981:Receptors, Prolactin / Q000235:genetics / Q000378:metabolism
D011944:Receptors, Androgen; D011981:Receptors, Prolactin; D000735:Androstenedione; D011374:Progesterone; D007986:Luteinizing Hormone