title: Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research.
abstract: Frequent outbreaks of highly pathogenic avian influenza and the increasing data available for comparative analysis require a central database specialized in influenza viruses (IVs). We have established the Influenza Virus Database (IVDB) to integrate information and create an analysis platform for genetic, genomic, and phylogenetic studies of the virus. IVDB hosts complete genome sequences of influenza A virus generated by Beijing Institute of Genomics (BIG) and curates all other published IV sequences after expert annotation. Our Q-Filter system classifies and ranks all nucleotide sequences into seven categories according to sequence content and integrity. IVDB provides a series of tools and viewers for comparative analysis of the viral genomes, genes, genetic polymorphisms and phylogenetic relationships. A search system has been developed for users to retrieve a combination of different data types by setting search options. To facilitate analysis of global viral transmission and evolution, the IV Sequence Distribution Tool (IVDT) has been developed to display the worldwide geographic distribution of chosen viral genotypes and to couple genomic data with epidemiological data. The BLAST, multiple sequence alignment and phylogenetic analysis tools were integrated for online data analysis. Furthermore, IVDB offers instant access to pre-computed alignments and polymorphisms of IV genes and proteins, and presents the results as SNP distribution plots and minor allele distributions. IVDB is publicly available at http://influenza.genomics.org.cn.
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, B-6 Airport Industrial Zone, Beijing 101300, China.
authors.forename: Suhua
authors.initials: S
authors.lastname: Chang
authors.forename: Jiajie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Liao
authors.forename: Xinxing
authors.initials: X
authors.lastname: Zhu
authors.forename: Dahai
authors.initials: D
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
authors.forename: George F
authors.initials: GF
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Huanming
authors.initials: H
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D030541:Databases, Genetic; D005814:Genes, Viral; D016679:Genome, Viral; D023281:Genomics; D009980:Influenza A virus / Q000235:genetics; D020407:Internet; D009975:Orthomyxoviridae / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012106:Research; D012984:Software; D018511:Systems Integration; D014584:User-Computer Interface; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D014764:Viral Proteins