trans-2,5-Disubstituted pyrrolidines: Rapid stereocontrolled access from sulfones.
A direct and versatile route for the reliable synthesis of trans-2,5-disubstituted pyrrolidines from pyroglutamic acid is reported, which can be conducted at scale and without chromatographic purification of key intermediates.
Moloney
Mark G
MG
The Department of Chemistry, Chemistry Research Laboratory, The University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
Panchal
Terry
T
Pike
Richard
R
D009942:Organometallic Compounds / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
D009942:Organometallic Compounds; D011759:Pyrrolidines; D013450:Sulfones