Effect of aging on stress reactivity of the adrenal cortex in laboratory primates. Dependence on the time of day.
Age-specific differences in the reaction of the hypothalamic-pituitary-adrenal system to acute psychoemotional stress (immobilization) was studied in female rhesus macaques aged 6-8 and 20-27 years at different time of the day. The reactivity of the hypothalamic-pituitary-adrenal system during immobilization at 15.00 was lower in old animals, while at 9.00 there were no age-specific differences or the reactivity was higher in old animals.
Goncharova
N D
ND
Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi. ndgoncharova@mail.ru
Oganyan
T E
TE
Smelkova
S A
SA
D000302:Adrenal Cortex / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000375:Aging / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D008253:Macaca mulatta / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*
D000324:Adrenocorticotropic Hormone