Low-dose intra-venous cyclophosphamide therapy in a patient with neurological complications of Behçet's disease.
Behçet's disease (BD) is a chronic relapsing-remitting inflammatory disorder of unknown origin, affecting multiple organs. Neurological involvement is one of the most devastating manifestations of BD and may be fatal. We report a 36-year-old woman with neuro-Behçet who was treated with low-dose pulse cyclophosphamide (St. Thomas' protocol) and methylprednisolone, with almost complete clinical remission.
Melillo
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N
Lupus Research Unit, The Rayne Institute, Lambeth Wing, St. Thomas' Hospital, London, SE1 7EH, UK.
Sangle
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S
Stanford
M R
MR
Andrews
T C
TC
D'Cruz
D P
DP
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications / Q000188:drug therapy*; D044383:Black People; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007275:Injections, Intravenous; D012074:Remission Induction; D020293:Vasculitis, Central Nervous System / Q000150:complications / Q000188:drug therapy* / Q000209:etiology
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide