CRSBP-1/LYVE-l-null mice exhibit identifiable morphological and functional alterations of lymphatic capillary vessels.
CRSBP-1, a membrane glycoprotein, can mediate cell-surface retention of secreted growth factors containing CRS motifs such as PDGF-BB. CRSBP-1 has recently been found to be identical to LYVE-1, a specific marker for lymphatic capillary endothelial cells. The in vivo role of CRSBP-1/LYVE-1 is unknown. CRSBP-1-null mice are overtly normal and fertile but exhibit identifiable morphological and functional alterations of lymphatic capillary vessels in certain tissues, marked by the constitutively increased interstitial-lymphatic flow and lack of typical irregularly-shaped lumens. The CRSBP-1 ligands PDGF-BB and HA enhance interstitial-lymphatic flow in wild-type mice but not in CRSBP-1-null animals.
Huang
S S
SS
Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104, USA. shuang@auxagen.com
Liu
I-Hua
IH
Smith
Tracy
T
Shah
Maulik R
MR
Johnson
Frank E
FE
Huang
Jung S
JS
D000818:Animals; D000077214:Becaplermin; D006023:Glycoproteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D006820:Hyaluronic Acid / Q000494:pharmacology; D008024:Ligands; D008208:Lymphatic System; D042601:Lymphatic Vessels / Q000473:pathology* / Q000503:physiopathology; D026901:Membrane Transport Proteins; D051379:Mice; D018345:Mice, Knockout; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D020574:Proto-Oncogene Proteins c-sis
D000077214:Becaplermin; D006023:Glycoproteins; D006820:Hyaluronic Acid; D008024:Ligands; D026901:Membrane Transport Proteins; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; C492273:LYVE1 protein, mouse