title: Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii.
abstract: Human endogenous retroviruses (HERVs) arose in antiquity from stable integration into the human genome. The mechanism for activation of HERVs has not been fully elucidated. Toxoplasmosis, caused by Toxoplasma gondii, is a medically important parasitic infection with worldwide distribution. To search for a tentative link between toxoplasmosis and HERV activation, HERV expression profiles of human neuroepithelial SK-N-MC cells infected with T. gondii were analyzed. Increased transcriptional activity of class I, II, and III HERV elements was observed in infected cells, suggesting that T. gondii can influence the transcription of HERVs in neuronal cells.
authors.affiliation: Medical Clinic III, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, D-68305 Mannheim, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Frank
authors.forename: Lorraine
authors.initials: L
authors.lastname: Jones-Brando
authors.forename: Christine
authors.initials: C
authors.lastname: Leib-Mosch
authors.forename: Robert
authors.initials: R
authors.lastname: Yolken
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Seifarth
mesh_terms: D000818:Animals; D002460:Cell Line; D020077:Endogenous Retroviruses / Q000235:genetics*; D020869:Gene Expression Profiling; D015967:Gene Expression Regulation, Viral; D006801:Humans; D046569:Neuroepithelial Cells / Q000469:parasitology* / Q000821:virology*; D012367:RNA, Viral / Q000096:biosynthesis; D014122:Toxoplasma; D014158:Transcription, Genetic; D014775:Virus Activation / Q000235:genetics
chemical_list: D012367:RNA, Viral