title: Pro-inflammatory cytokinemia is frequently found in Down syndrome patients with hematological disorders.
abstract: Down syndrome (DS) patients are frequently complicated with infections, autoimmune phenomena and hematological disorders, including transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukaemia (AMKL) in later life. In this study, serum levels of cytokines from 23 TAM and 15 AMKL patients were examined using the highly sensitive microsphere fluorescence system. Statistical differences between DS neonates with or without TAM were found in IL-1beta [median 7.0 pg/ml (0.34-271.6) verses 0.05 pg/ml (0.0-2.4), p=0.034], TNF-alpha [8.11 pg/ml (0.1-253.0) verses 0.41 pg/ml (0.1-1.5), p=0.041], and IFN-gamma [20.0 pg/ml (0.14-406.3) verses 1.5 pg/ml (0.14-5.79), p=0.036]. Moreover, abnormal inflammatory cytokinemia was also found in myelodysplastic syndrome (MDS) and AMKL with DS. These abnormal cytokinemia may have a role in the pathophysiology of TAM, MDS and AMKL in DS, especially in liver fibrosis or myelofibrosis.
authors.affiliation: Department of Hematology/Oncology, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu, Shibukawa, Gunma 377-8577, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Mizuho
authors.initials: M
authors.lastname: Ogasawara
authors.forename: Myoung-Ja
authors.initials: MJ
authors.lastname: Park
authors.forename: Masahiko
authors.initials: M
authors.lastname: Katoh
authors.forename: Hisanori
authors.initials: H
authors.lastname: Minakami
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kitoh
authors.forename: Seiji
authors.initials: S
authors.lastname: Kojima
authors.forename: Keisei
authors.initials: K
authors.lastname: Kawa
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kimura
mesh_terms: D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000097:blood*; D006402:Hematologic Diseases / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007947:Leukemia, Megakaryoblastic, Acute / Q000097:blood*; D009190:Myelodysplastic Syndromes / Q000097:blood*; D055728:Primary Myelofibrosis / Q000175:diagnosis / Q000276:immunology
chemical_list: D016207:Cytokines