title: [Effects of fufangdenshen tablets on human atherosclerotic plasma protein using proteomic technique].
abstract: OBJECTIVE
  To research the effects of fufangdenshen tablets on atherosclerotic plasma protein using proteomic technique and further explore its potential molecular mechanism to cure atherosclerosis.
  
  
  METHODS
  The plasma of normal, atherosclerosis and cured group were collected, and the albumin in plasma was removed. Proteomic protocol involved of 2-DE, image analysis and spectrometry detection was used to detect regulated plasma protein by fufangdenshen tablets.
  
  
  RESULTS
  3 decreased expressed and 6 higher protein in atherosclerotic plasma could be recovered by fufangdenshen tablets. The levels of fibrinogen, Granzyme C and immunoglobulin were decreased by fufangdenshen tablets.
  
  
  CONCLUSIONS
  The levels of fibrinogen, Granzyme C in atherosclerotic plasma could be decreased by fufangdenshen tablets. The effects of fufangdenshen tablets on atherosclerosis included that: inhibition of adhesion of monocyte, inhibition of proliferation and migration of VSMC, and weakening of inflammation.
authors.affiliation: Institute of Radiation Medicine, Beijing, China.
authors.forename: Zeng-chun
authors.initials: ZC
authors.lastname: Ma
authors.forename: Yue
authors.initials: Y
authors.lastname: Gao
authors.forename: Hong-ling
authors.initials: HL
authors.lastname: Tan
authors.forename: Cheng-rong
authors.initials: CR
authors.lastname: Xiao
authors.forename: Hong-jin
authors.initials: HJ
authors.lastname: Wu
authors.forename: Sheng-qi
authors.initials: SQ
authors.lastname: Wang
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism*; D053804:Granzymes / Q000097:blood; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008875:Middle Aged; D010946:Plants, Medicinal / Q000737:chemistry; D040901:Proteomics; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013607:Tablets
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007136:Immunoglobulins; D013607:Tablets; D005340:Fibrinogen; D053804:Granzymes