Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy.
In order to provide a suitable device that would contain water-soluble drugs, highly water-soluble gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres (CMS-Gd-DTPA) were prepared by the emulsion method using glutaraldehyde as a cross-linker and Span 80 as a surfactant for gadolinium neutron-capture therapy of cancer. The gadolinium content and the mass median diameter of CMS-Gd-DTPA were estimated. The size and morphology of the CMS-Gd-DTPA were strongly influenced by the initial applied weight ratio of Gd-DTPA:chitosan. FTIR spectra showed that the electrostatic interaction between chitosan and Gd-DTPA accelerated the formation of gadolinium-enriched chitosan microspheres. Sufficient amounts of glutaraldehyde and Span 80 were necessary for producing discrete CMS-Gd-DTPA. The CMS-Gd-DTPA having a mass median diameter 11.7microm and 11.6% of gadolinium could be used in Gd-NCT following intratumoral injection.
Saha
Tapan Kumar
TK
Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh. tksaha_ju@yahoo.com
Ichikawa
Hideki
H
Fukumori
Yoshinobu
Y
D000970:Antineoplastic Agents / Q000008:administration & dosage; D048271:Chitosan; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000008:administration & dosage*; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D008863:Microspheres; D017247:Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D048271:Chitosan; D019786:Gadolinium DTPA