title: [Endothelial dysfunction and oxidative stress in sepsis].
abstract: Central to the pathophysiology of sepsis and septic shock is an alteration in endothelial cell function and oxidative stress. Highly complex, integrated responses that include the activation of a number of cell types, inflammatory mediators and the hemostatic system are involved in endothelial dysfunction. On the other hand, the imbalance between the excessive production of reactive oxygen species and/or inadequate antioxidative defenses characterizes the oxidative stress. The overview of all these mechanisms suggests clinical biochemical markers as a possible therapeutic target together with correct intervention timing.
authors.affiliation: Istituto di Fisiologia Clinica del CNR, Milano. ifcnig@tin.it
authors.forename: O
authors.initials: O
authors.lastname: Parodi
authors.forename: B
authors.initials: B
authors.lastname: De Chiara
authors.forename: J
authors.initials: J
authors.lastname: Campolo
authors.forename: V
authors.initials: V
authors.lastname: Sedda
authors.forename: E
authors.initials: E
authors.lastname: Roubina
mesh_terms: D015415:Biomarkers / Q000097:blood; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D018384:Oxidative Stress; D018805:Sepsis / Q000503:physiopathology* / Q000628:therapy
chemical_list: D015415:Biomarkers