Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation.
A considerable body of evidence suggests that formation of potent reactive oxygen species and resulting oxidative/nitrative stress play a major role in acute and chronic inflammation and pain. Much of the knowledge in this field has been gathered by the use of pharmacological and genetic approaches. In this mini review, we will evaluate recent advances made towards understanding the roles of reactive oxygen species in inflammation, focusing in particular on superoxide and peroxynitrite. Given the limited space to cover this broad topic, here we will refer the reader to comprehensive review articles whenever possible.
Salvemini
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Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St. Louis, MO 63110-0250, USA. salvemd@slu.edu
Doyle
T M
TM
Cuzzocrea
S
S
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D018384:Oxidative Stress / Q000502:physiology*; D030421:Peroxynitrous Acid / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D017382:Reactive Oxygen Species; D013481:Superoxides; D030421:Peroxynitrous Acid; C002744:3-nitrotyrosine; D014443:Tyrosine