title: Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%.
abstract: In this review, we present an overview of the Gene Ontology (GO) structure and describe how the GO is implemented for Sz. pombe and made available via Sz. pombe GeneDB (http://www.genedb.org/genedb/pombe/). We give a detailed progress report of Sz. pombe GO annotation, providing the current status of both manual and automatic annotations. Fission yeast has at least one GO annotation for 98.3% of its genes (excluding annotations to 'unknown' terms), greater than the current percentage coverage for any other organism. Approximately 65% (3225 gene products) have at least one annotation to each of the three ontologies (biological process, cellular component and molecular function). Approximately 30% (1443 gene products) have GO terms derived directly from small-scale experiments in fission yeast, supporting the validity of fission yeast as a model eukaryote and a reference organism.
authors.affiliation: Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Aslett
authors.forename: Valerie
authors.initials: V
authors.lastname: Wood
mesh_terms: D019295:Computational Biology; D030541:Databases, Genetic; D005800:Genes, Fungal / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics*
chemical_list: D029702:Schizosaccharomyces pombe Proteins