title: Sebaceous carcinoma of the caruncle.
abstract: OBJECTIVE
  To report a case of sebaceous carcinoma of the caruncle.
  
  
  METHODS
  A 68-year-old woman developed a slowly enlarging mass of her left caruncle. Incisional biopsy elsewhere was interpreted histopathologically as invasive squamous cell carcinoma. On the basis of the clinical findings, however, we suspected sebaceous carcinoma. Excisional biopsy with frozen section control was undertaken and the lesion was studied histopathologically.
  
  
  RESULTS
  Histopathological examination disclosed infiltration of the caruncular stroma by lobules of a malignant neoplasm that had prominent cytoplasmic vacuoles, typical of sebaceous carcinoma.
  
  
  CONCLUSIONS
  Although it is best known to arise in the meibomian glands of the tarsus, sebaceous carcinoma can rarely arise in the caruncle and can be misinterpreted histopathologically as squamous cell carcinoma.
authors.affiliation: Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA. jerryshields@comcast.net
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Brian P
authors.initials: BP
authors.lastname: Marr
authors.forename: Ralph C
authors.initials: RC
authors.lastname: Eagle
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000473:pathology* / Q000601:surgery; D000368:Aged; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D012626:Sebaceous Gland Neoplasms / Q000473:pathology* / Q000601:surgery