title: The place and role of serologic methods in detecting Helicobacter pylori infection.
abstract: The aim of the study was to determine the place and role of serologic methods in detecting Helicobacter pylori (H. pylori) infection, on the basis of estimated enzyme-linked immunosorbent assay (ELISA) and complement fixation test (CFT) sensitivity and specificity. A total of 549 patients were included in the study. ELISA and CFT as serologic methods were compared with invasive methods (rapid urease test--CLO test, culture, histology). The sensitivity of serologic methods was above 90%, and their specificity was around 80%. Study results confirmed the value, reliability and usefulness of serologic methods in the detection of H. pylori infection.
authors.affiliation: University Department of Medicine, General Hospital Sveti Duh, Zagreb, Croatia. marinko.marusic1@zg.t-com.hr
authors.forename: Marinko
authors.initials: M
authors.lastname: Marusić
authors.forename: Vladimir
authors.initials: V
authors.lastname: Presecki
authors.forename: Miroslava
authors.initials: M
authors.lastname: Katicić
authors.forename: Mara
authors.initials: M
authors.lastname: Dominis
authors.forename: Smilja
authors.initials: S
authors.lastname: Kalenić
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000302:isolation & purification*; D003168:Complement Fixation Tests / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D000907:Antibodies, Bacterial