Success rate of second-trimester termination of pregnancy using misoprostol.
OBJECTIVE
To evaluate the efficacy and maternal side effects of misoprostol usage for second trimester termination in Siriraj Hospital.


METHODS
Descriptive cross sectional study.


METHODS
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University.


METHODS
The medical records of 94 pregnant women, between 14-28 weeks of gestation, who were admitted for medical termination of pregnancy, were reviewed. Each patient received 400 microg of misoprostol vaginally every 12 hours as recommended by RTCOG for termination of pregnancy. Main outcome measures included success rate of abortion within 48 hours, induction to abortion interval and maternal side effects.


RESULTS
The success rate of abortion within 48 hours was 89.46%. Mean induction to abortion interval was 22.1 hours. The most common maternal side effect was fever (24.5%). The rate of incomplete abortion was 28.6% of successful cases. No factor, including age, parity and viability of fetus affected the success rate significantly. No serious maternal complication was detected.


CONCLUSIONS
Misoprostol 400 microg vaginally every 12 hours can be used effectively and safely for second trimester pregnancy termination.
Prachasilpchai
Natthinee
N
Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Russameecharoen
Kusol
K
Borriboonhirunsarn
Dittakarn
D
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000028:Abortion, Induced; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013997:Time Factors; D016896:Treatment Outcome
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol