Endophthalmitis after open globe injury: microbiologic spectrum and susceptibilities of isolates.
OBJECTIVE
To present the microbiologic spectrum and susceptibilities of isolates in posttraumatic endophthalmitis, and to provide a review of the literature.


METHODS
Retrospective consecutive case series.


METHODS
A review of 1182 consecutive open globe injuries was performed, identifying 10 patients with culture-proven endophthalmitis.


RESULTS
Thirteen organisms were isolated from 10 eyes with posttraumatic endophthalmitis. Isolated organisms included Streptococcus species (46.2%), coagulase-negative Staphylococcus (23.1%), and Bacillus cereus (15.4%). All organisms tested were susceptible to vancomycin and tobramycin. The most commonly isolated organisms from an aggregate posttraumatic endophthalmitis pool of 372 cases obtained by literature-based meta-analysis were coagulase-negative Staphylococcus (21.5%) and Bacillus cereus (18.5%).


CONCLUSIONS
We report a high prevalence of gram-positive pathogens and a notable prevalence of Bacillus cereus in posttraumatic endophthalmitis. Susceptibility results suggest that posttraumatic endophthalmitis isolates are generally susceptible to vancomycin and tobramycin.
Chhabra
Sachin
S
Wills Eye Retina Service, Philadelphia, Pennsylvania 19107, USA. derek_kunimoto@yahoo.com
Kunimoto
Derek Y
DY
Kazi
Lubna
L
Regillo
Carl D
CD
Ho
Allen C
AC
Belmont
Jonathan
J
Maguire
Joseph
J
Vander
James
J
Brown
Gary C
GC
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001082:Aqueous Humor / Q000382:microbiology; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D024881:Drug Resistance, Bacterial; D009877:Endophthalmitis / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000382:microbiology*; D015807:Eye Injuries, Penetrating / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D014822:Vitreous Body / Q000382:microbiology
D000900:Anti-Bacterial Agents