title: A floating metal microelectrode array for chronic implantation.
abstract: Implantation of multi-electrode arrays is becoming increasingly more prevalent within the neuroscience research community and has become important for clinical applications. Many of these studies have been directed towards the development of sensory and motor prosthesis. Here, we present a multi-electrode system made from biocompatible material that is electrically and mechanically stable, and employs design features allowing flexibility in the geometric layout and length of the individual electrodes within the array. We also employ recent advances in laser machining of thin ceramic substrates, application of ultra-fine line gold conductors to ceramic, fabrication of extremely flexible cables, and fine wire management techniques associated with juxtaposing metal microelectrodes within a few hundred microns of each other in the development of a floating multi-electrode array (FMA). We implanted the FMA in rats and show that the FMA is capable of recording both spikes and local field potentials.
authors.affiliation: California Institute of Technology, Division of Biology, MC 216-76 Pasadena, CA 91125, United States. sam@vis.caltech.edu
authors.forename: Sam
authors.initials: S
authors.lastname: Musallam
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Bak
authors.forename: Philip R
authors.initials: PR
authors.lastname: Troyk
authors.forename: Richard A
authors.initials: RA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology; D020099:Coated Materials, Biocompatible; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D008564:Membrane Potentials / Q000502:physiology; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013057:Spectrum Analysis
chemical_list: D020099:Coated Materials, Biocompatible