title: Primary breast lymphoma: long-term treatment outcome and prognosis.
abstract: Between 1980 and 2002, 32 cases diagnosed as primary breast lymphoma were reviewed. Among them, 18 patients were stage I and 14 were stage II. Four patients underwent mastectomy and the remainder underwent lumpectomy. Twenty-eight patients received postoperative chemotherapy and 20 patients received postoperative radiotherapy. After a median follow-up of 76 (range 25 - 245) months, the 5-year overall survival and relapse-free survival was 69.3% and 47.7%, respectively. Ann Arbor stage, International Prognostic Index (IPI) excluding stage, lactic dehydrogenase (LDH) and radiotherapy were significant factors for relapse-free survival. We conclude that younger age and elevated LDH were apparent characters of the patients in our study. IPI excluding stage was a valuable prognostic factor. Combined radiotherapy and chemotherapy appeared to be important for treatment.
authors.affiliation: Department of Radiation Oncology. Fudan University, Shanghai, PR China. linyuancai@yahoo.com
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
authors.forename: Xiao-Mao
authors.initials: XM
authors.lastname: Guo
authors.forename: Kun-Wei
authors.initials: KW
authors.lastname: Shen
authors.forename: Jia-Lei
authors.initials: JL
authors.lastname: Wang
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012044:Regression Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents