The bug in MyD88 dependency.
The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus.
van Lier
René A W
RA
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Lutter
René
R
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001228:Aspergillosis / Q000235:genetics / Q000276:immunology*; D001232:Aspergillus fumigatus; D003713:Dendritic Cells; D008172:Lung Diseases, Fungal / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology*; D051379:Mice; D053594:Myeloid Differentiation Factor 88; D013601:T-Lymphocytes / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88