title: Biomarker discovery by proteomics: challenges not only for the analytical chemist.
abstract: This forum article outlines some of the major challenges in present day biomarker discovery research. Notably the dilemma of reaching sufficient concentration sensitivity versus the required analysis time per sample is highlighted using a model calculation. A number of possible developments and recent research findings are considered to show possible ways out of this dilemma. Finally, the challenge of processing large, megavariate datasets prior to statistical analysis is presented.
authors.affiliation: University of Groningen, Centre of Pharmacy, Analytical Biochemistry, Antonius Deusinglaan 1, 9713 AV, Groningen, the Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Horvatovich
authors.forename: Natalia
authors.initials: N
authors.lastname: Govorukhina
authors.forename: Rainer
authors.initials: R
authors.lastname: Bischoff
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D019295:Computational Biology; D006801:Humans; D040901:Proteomics / Q000379:methods*; D012106:Research; D049490:Systems Biology
chemical_list: D015415:Biomarkers