Molecular modeling of glycosyltransferases.
Glycosyltransferases, the enzymes that build oligosaccharides and glycoconjugates, have received much interest in recent years owing to their biological functions and their potential uses in biotechnology. The analysis of the wealth of sequences that are now available in databases allowed the classification in different families characterized by conserved peptide motifs. Nevertheless, only a limited number of crystal structures is available and molecular modeling appears to be an inescapable tool for rationalization of binding data, engineering of enzyme properties, and design of inhibitors that would be of interest as therapeutic compounds. Because of sequence diversity and limited experimental data, molecular modeling of these enzymes is not straightforward and utilizes the most recent tools, such as fold recognition programs.
Imberty
Anne
A
Centre de Recherches sur les Macromolécules Végétales, CNRS, Grenoble, France.
Wimmerová
Michaela
M
Koca
Jaroslav
J
Breton
Christelle
C
D000595:Amino Acid Sequence; D001665:Binding Sites; D002241:Carbohydrates / Q000737:chemistry; D016695:Glycosyltransferases / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D020407:Internet; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017510:Protein Folding; D020539:Sequence Analysis, Protein / Q000379:methods; D017386:Sequence Homology, Amino Acid; D012984:Software; D040681:Structural Homology, Protein
D002241:Carbohydrates; D016695:Glycosyltransferases