title: Long-term monitoring of gait in Parkinson's disease.
abstract: A new system for long-term monitoring of gait in Parkinson's disease (PD) has been developed and validated. The characteristics of every stride taken over 10-h epochs were acquired using a lightweight ankle-mounted sensor array that transmitted data wirelessly to a small pocket PC at a rate of 100 Hz. Stride was calculated from the vertical linear acceleration and pitch angular velocity of the leg with an accuracy of 5 cm. Results from PD patients (5) demonstrate the effectiveness of long-term monitoring of gait in a natural environment. The small, variable stride length characteristic of Parkinsonian gait, and fluctuations of efficacy associated with levodopa therapy, such as delayed onset, wearing off, and the 'off/on' effect, could reliably be detected from long-term changes in stride length.
authors.affiliation: Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA. steven.moore@mssm.edu
authors.forename: Steven T
authors.initials: ST
authors.lastname: Moore
authors.forename: Hamish G
authors.initials: HG
authors.lastname: MacDougall
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Gracies
authors.forename: Helen S
authors.initials: HS
authors.lastname: Cohen
authors.forename: William G
authors.initials: WG
authors.lastname: Ondo
mesh_terms: D000328:Adult; D000465:Algorithms; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D002138:Calibration; D034201:Computers, Handheld; D016903:Drug Monitoring / Q000295:instrumentation*; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology / Q000517:prevention & control; D004582:Electronics, Medical; D005240:Feasibility Studies; D005260:Female; D005684:Gait; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa