Nodular basal cell carcinoma in Gorlin's syndrome treated with systemic photodynamic therapy and interstitial optical fiber diffuser laser.
Nodular basal cell carcinomas resistant to multiple forms of treatment in two patients with nevoid basal cell carcinoma syndrome (Gorlin's syndrome) were treated with systemic porfimer sodium-based photodynamic therapy. Interstitially placed optical diffuser fibers were used to deliver light. Good response to treatment was seen on clinical evaluation and on measurement by a 20-MHz high-resolution ultrasound.
Madan
Vishal
V
Dermatology Centre, Hope Hospital, Salford, Manchester, M6 8HD, UK.
Loncaster
Juliette A
JA
Allan
Donald
D
Lear
John T
JT
Sheridan
Linda
L
Leach
Catherine
C
Allan
Ernest
E
D000328:Adult; D001478:Basal Cell Nevus Syndrome / Q000188:drug therapy*; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D055095:Optics and Photonics; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*
D017319:Photosensitizing Agents; D017323:Dihematoporphyrin Ether