Presence of the exoU gene of Pseudomonas aeruginosa is correlated with cytotoxicity in MDCK cells but not with colonization in BALB/c mice.
A total of 141 independent strains of Pseudomonas aeruginosa with different heterogeneities in the exo gene (exoS, exoT, exoU, and exoY) background were examined for their pathogenic roles. Results indicated that the exoU gene is the major contributor to cytotoxicity in Madin-Darby canine kidney cells but is not related to bacterial colonization in mice.
Lin
Hsi-Hsun
HH
Department of Infectious Disease, E-DA Hospital/I-Shou University, Kaoshiung, Taiwan.
Huang
Shiao-ping
SP
Teng
Hsiu-Chen
HC
Ji
Dar-Der
DD
Chen
Yao-Shen
YS
Chen
Ya-Lei
YL
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D016923:Cell Death; D002460:Cell Line; D004195:Disease Models, Animal; D004285:Dogs; D005798:Genes, Bacterial; D051379:Mice; D008807:Mice, Inbred BALB C; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics*
D001426:Bacterial Proteins; D037521:Virulence Factors; C111749:pseudomonas exoprotein A protein, Pseudomonas aeruginosa