Contact paracrine inhibitory networks within human gestational tissues.
We have determined the effects of separating chorion from decidua on the production of cytokines and prostaglandins. Chorionic production always exceeded that of decidua. Production rates were significantly greater in separated explants compared with intact choriodecidua, which suggests a potential contact paracrine inhibitory network.
Sato
Timothy A
TA
Liggins Institute, University of Auckland, New Zealand.
Mitchell
Murray D
MD
D002823:Chorion / Q000378:metabolism*; D016207:Cytokines / Q000037:antagonists & inhibitors*; D003656:Decidua / Q000378:metabolism*; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009994:Osmolar Concentration; D019899:Paracrine Communication / Q000502:physiology*; D011247:Pregnancy; D011448:Prostaglandin Antagonists / Q000096:biosynthesis*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D015850:Interleukin-6; D011448:Prostaglandin Antagonists; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007770:L-Lactate Dehydrogenase; D015232:Dinoprostone