The role of myosin Va in secretory granule trafficking and exocytosis.
It emerges that myosin Va plays multiple roles in the trafficking of SGs (secretory granules). In addition to a function in the capture and transport of newly formed SGs in the F-actin-rich cortex, myosin Va is implicated in late transport events of these organelles, which precede their exocytosis. Consistent with these roles, interactions of myosin Va with an array of well-known proteins involved in regulated protein secretion have been documented.
Eichler
T W
TW
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway.
Kögel
T
T
Bukoreshtliev
N V
NV
Gerdes
H-H
HH
D005089:Exocytosis / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D020460:Melanosomes / Q000502:physiology; D009154:Mutation; D018995:Myosin Heavy Chains / Q000235:genetics / Q000502:physiology*; D024701:Myosin Type V / Q000235:genetics / Q000502:physiology*; D021381:Protein Transport; D022142:Secretory Vesicles / Q000502:physiology*
C077511:MYO5A protein, human; D024701:Myosin Type V; D018995:Myosin Heavy Chains