title: Functional variations in the JWA gene are associated with increased odds of leukemias.
abstract: The association between the -76G>C in the 5'-flanking region and 723T>G in JWA exon three variants were examined for risk of leukemia development in a hospital-based case-control study of 201 leukemia patients and 243 cancer-free controls in a Chinese population. Studies showed that the -76C allele was associated with significantly increased odds of leukemia but the 723G allele was correlated with marked decreased odds of leukemia. Variation in the -76C allele resulted in almost complete loss of oxidative stress stimulated transcription activities of the promoter fragment.
authors.affiliation: Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University,140 Hanzhong Road, Nanjing 210029, People's Republic of China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Shen
authors.forename: Wei-Yan
authors.initials: WY
authors.lastname: Tang
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Shu
authors.initials: S
authors.lastname: Huang
authors.forename: Ai-Ping
authors.initials: AP
authors.lastname: Li
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007938:Leukemia / Q000235:genetics*; D008297:Male; D026901:Membrane Transport Proteins; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012189:Retrospective Studies; D014158:Transcription, Genetic
chemical_list: C484566:ARL6IP5 protein, human; D006360:Heat-Shock Proteins; D047908:Intracellular Signaling Peptides and Proteins; D026901:Membrane Transport Proteins