title: Does perinatal asphyxia impair cognitive function without cerebral palsy?
abstract: Some studies on neurodevelopmental outcomes after neonatal encephalopathy have suggested that cognitive deficits do not occur in the absence of cerebral palsy. It is increasingly apparent that childhood survivors of overt neonatal encephalopathy may have cognitive impairments, even in the absence of functional motor deficits. The risk of cognitive deficits is related to the severity of neonatal encephalopathy and the pattern of brain injury on neuroimaging, particularly the watershed pattern of injury. A better understanding of the risk factors for cognitive abnormalities after neonatal encephalopathy will ultimately lead to interventions to prevent these deficits. Identifying the full spectrum of neurodevelopmental outcomes after neonatal encephalopathy will also allow care givers to identify children requiring early intervention to maximise their potential for independent function throughout development.
authors.affiliation: Department of Pediatrics, University of California, San Francisco, California, USA.
authors.forename: F F
authors.initials: FF
authors.lastname: Gonzalez
authors.forename: S P
authors.initials: SP
authors.lastname: Miller
mesh_terms: D000818:Animals; D001238:Asphyxia Neonatorum / Q000523:psychology*; D015415:Biomarkers / Q000378:metabolism; D001927:Brain Diseases / Q000209:etiology*; D002547:Cerebral Palsy; D003072:Cognition Disorders / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging
chemical_list: D015415:Biomarkers