title: Increased sympathetic activity present in early hypertensive pregnancy is not lowered by plasma volume expansion.
abstract: OBJECTIVE
  To evaluate whether sympathetic activity is increased in early-onset hypertensive pregnancy and whether this can be influenced by management with plasma volume expansion.
  
  
  METHODS
  The study group consisted of 74 subjects, of which 37 had early-onset hypertensive disorders of pregnancy (preeclampsia or gestational hypertension with fetal growth restriction), who were included at 24 to 34 weeks in a randomized controlled trial of management with (n = 18) or without (n = 19) plasma volume expansion. Heart rate and blood pressure variabilities, LF/HF ratio for heart rate, baroreflex sensitivity, and phase difference at low frequency (LF approximately 0.1 Hz) were calculated by spectral analysis from continuous heart rate and blood pressure recordings of the finger pulse wave (Portaprestrade mark, TNO). Measurements were performed at inclusion, after 20 to 40 hours and after 65 to 100 hours. The control group consisted of 29 women with a normal pregnancy and 8 women who had late-onset preeclampsia after 34 weeks. Controls were measured at 32 weeks. All controls had a normal blood pressures at that time.
  
  
  RESULTS
  LF variability of heart rate and blood pressure were significantly higher and baroreflex sensitivity was significantly lower in early-onset patients compared with normal controls. A significant trend towards higher LF variability of blood pressure and lower baroreflex sensitivity was found from normal controls to late-onset controls to early-onset patients. Parameters of sympathetic activity were not influenced by plasma volume expansion.
  
  
  CONCLUSIONS
  Sympathetic activity was increased in early-onset hypertensive pregnancy. However, this was not affected by management with plasma volume expansion, suggesting that hypovolaemia in preeclampsia is a secondary phenomenon.
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Wieneke P
authors.initials: WP
authors.lastname: Metsaars
authors.forename: Wessel
authors.initials: W
authors.lastname: Ganzevoort
authors.forename: John M
authors.initials: JM
authors.lastname: Karemaker
authors.forename: Saskia
authors.initials: S
authors.lastname: Rang
authors.forename: Hans
authors.initials: H
authors.lastname: Wolf
mesh_terms: D000328:Adult; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy* / Q000503:physiopathology*; D010952:Plasma Substitutes / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D013057:Spectrum Analysis; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes