title: Synthesis and structure-activity studies of antofine analogues as potential anticancer agents.
abstract: Due to the profound cytotoxicities and interesting biochemical aspects, phenanthroindolizidine alkaloids have received an attention as potential therapeutic leads. To define the features of the molecule that are essential for cytotoxicity, we have synthesized and evaluated a series of phenanthroindolizidine alkaloid, antofine, analogues with different substituents on the phenanthrene ring. The systematic structure activity relationship studies elucidate the essential functional group requirement of phenanthrene ring, providing the basis for further development of phenanthroindolizidine alkaloids.
authors.affiliation: College of Pharmacy, Seoul National University, San 56-1, Shilim, Kwanak, Seoul 151-742, Republic of Korea.
authors.forename: Ye
authors.initials: Y
authors.lastname: Fu
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Min
authors.forename: Taeho
authors.initials: T
authors.lastname: Lee
authors.forename: Jaekwang
authors.initials: J
authors.lastname: Lee
authors.forename: Maosheng
authors.initials: M
authors.lastname: Cheng
authors.forename: Sanghee
authors.initials: S
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D010618:Phenanthrolines; C473343:antofine