STDP rule endowed with the BCM sliding threshold accounts for hippocampal heterosynaptic plasticity.
We have combined the nearest neighbour additive spike-timing-dependent plasticity (STDP) rule with the Bienenstock, Cooper and Munro (BCM) sliding modification threshold in a computational model of heterosynaptic plasticity in the hippocampal dentate gyrus. As a result we can reproduce (1) homosynaptic long-term potentiation of the tetanized input, and (2) heterosynaptic long-term depression of the untetanized input, as observed in real experiments.
Benuskova
Lubica
L
Knowledge Engineering & Discovery Research Institute, Auckland University of Technology, Auckland, New Zealand. lbenusko@aut.ac.nz
Abraham
Wickliffe C
WC
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology*; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D013997:Time Factors