title: Influenza vaccine effectiveness among 50-64-year-old persons during a season of poor antigenic match between vaccine and circulating influenza virus strains: Colorado, United States, 2003-2004.
abstract: During the 2003-2004 influenza season, we conducted a case-control study of influenza vaccine effectiveness (VE) among Colorado residents aged 50-64 years. Cases (n=330) were identified from laboratory-confirmed influenza reports to the Colorado Department of Public Health and Environment (CDPHE). Controls (n=1055) were recruited by random-digit dial telephone survey. VE was 60% (43-72%) and 48% (21-66%) among those without and with high-risk medical conditions, respectively. VE was 90% (68-97%) and 36% (0-63%) against influenza-related hospitalization for persons without and with high-risk conditions, respectively.
authors.affiliation: Centers for Disease Control and Prevention (CDC), National Immunization Program (NIP), Epidemiology and Surveillance Division (ESD), Centers for Disease Control and Prevention, Atlanta, GA 30333, United States. gah9@cdc.gov
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Herrera
authors.forename: Marika K
authors.initials: MK
authors.lastname: Iwane
authors.forename: Margaret
authors.initials: M
authors.lastname: Cortese
authors.forename: Cedric
authors.initials: C
authors.lastname: Brown
authors.forename: Ken
authors.initials: K
authors.lastname: Gershman
authors.forename: Alyson
authors.initials: A
authors.lastname: Shupe
authors.forename: Francisco
authors.initials: F
authors.lastname: Averhoff
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Chaves
authors.forename: Paul
authors.initials: P
authors.lastname: Gargiullo
authors.forename: Carolyn B
authors.initials: CB
authors.lastname: Bridges
mesh_terms: D000940:Antigenic Variation; D016022:Case-Control Studies; D003120:Colorado; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification* / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012621:Seasons; D013045:Species Specificity; D016896:Treatment Outcome; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D007252:Influenza Vaccines