The association of chronic hepatitis B and myopathy.
In two patients with chronic hepatitis B and myopathy, muscle biopsy showed necrosis and scarce inflammatory infiltrates. CD8+ cells surrounded some non-necrotic fibers. Hepatitis B virus (HBV) DNA and antigens were found inside intact muscle fibers. Major histocompatibility complex class I antigens were coexpressed with viral antigens. In one patient, symptoms improved during antiviral therapy. HBV can infect muscle fibers and an immune-mediated response to viral antigens may cause muscle injury.
Capasso
M
M
Aging Research Center CeSI , Gabriele d'Annunzio University Foundation Chieti-Pescara and Interuniversitary Institute of Myology, Chieti, Italy.
Di Muzio
A
A
Comar
M
M
Robuffo
I
I
Gambi
A
A
Crovella
S
S
Pizzigallo
E
E
Campello
C
C
Uncini
A
A
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000188:drug therapy; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D018482:Muscle, Skeletal / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D009135:Muscular Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology*; D009336:Necrosis; D016133:Polymerase Chain Reaction
D000956:Antigens, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D015395:Histocompatibility Antigens Class I