title: Effectiveness of childhood vaccination against rotavirus in sub-Saharan Africa: the case of Nigeria.
abstract: Rotavirus diarrhoea is associated with high childhood mortality in developing countries. A new vaccine was recently licensed in Mexico. The objective of this study was to assess the effectiveness of routine childhood vaccination by this new vaccine in a developing country. We constructed a decision tree to compare two alternatives: "no vaccination programme" and "vaccination programme". The estimates used for disease incidence, vaccine efficacy and coverage rates were derived from published data. We followed a hypothetical Nigerian cohort from birth to age five. The vaccine programme would prevent 284,000 cases of rotavirus diarrhoea annually and 6129 deaths due to the disease. In this study in a sub-Saharan country, we showed that rotavirus vaccination with a new vaccine substantially reduces the number of deaths from rotavirus diarrhoea and may be of great use in developing countries.
authors.affiliation: Service Universitaire des Maladies Infectieuses et du Voyageur, Centre Hospitalier de Tourcoing, France. hugues.melliez@infonie.fr
authors.forename: H
authors.initials: H
authors.lastname: Melliez
authors.forename: P Y
authors.initials: PY
authors.lastname: Boelle
authors.forename: S
authors.initials: S
authors.lastname: Baron
authors.forename: Y
authors.initials: Y
authors.lastname: Mouton
authors.forename: Y
authors.initials: Y
authors.lastname: Yazdanpanah
mesh_terms: D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009549:Nigeria; D022243:Rotavirus Vaccines / Q000276:immunology*; D014611:Vaccination
chemical_list: D022243:Rotavirus Vaccines