Fluxional additives: a second generation control in enantioselective catalysis.
The concept of "fluxional additives", additives that can adopt enantiomeric conformations depending on the chiral information in the ligand, is demonstrated in enantioselective Diels-Alder and nitrone cycloaddition reactions. The additive design is modular, and diverse structures are accessible in three steps. Chiral Lewis acids from main group and transition metals show enhancements in enantioselectivity in the presence of these additives.
Sibi
Mukund P
MP
Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, North Dakota 58105, USA. Mukund.Sibi@ndsu.edu
Manyem
Shankar
S
Palencia
Hector
H