[Effect of vasoactive intestinal peptide and epidermal growth factor on the adhesion of eosinophils to bronchial epithelial cells].
OBJECTIVE
To investigate the effect of intrapulmonary regulatory peptides on adhesion of eosinophils (EOS) to bronchial epithelial cells (BECs).


METHODS
Two regulatory peptides, namely vasoactive intestinal peptide (VIP) and epidermal growth factor (EGF) were investigated. VIP and EGF were observed on the secretion of ILs and expression of intercellular adhesion molecule-1 (ICAM-1).


RESULTS
VIP and EGF could decrease ILs secretion and ICAM-1 expression.


CONCLUSIONS
VIP and EGF inhibited the adhesion of EOS to BEC in the inflammatory process to lighten the airway inflammation.
Li
Xiang
X
Research Department of Applied Physiology, Medical College, Hunan Normal University, Changsha 410006, China.
Xing
Xiu-mei
XM
Zhang
Jian-song
JS
Tan
Yu-rong
YR
D000818:Animals; D001980:Bronchi / Q000166:cytology*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D004804:Eosinophils / Q000166:cytology*; D004815:Epidermal Growth Factor / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D008297:Male; D011817:Rabbits; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*
D015848:Interleukin-5; D018799:Intercellular Adhesion Molecule-1; D014660:Vasoactive Intestinal Peptide; D004815:Epidermal Growth Factor