title: Highly regioselective catalytic oxidative coupling reactions: synthetic and mechanistic investigations.
abstract: A highly efficient and regioselective Pd-catalyzed method for the oxidative coupling of arylpyridine derivatives is reported. Remarkably, the reactions proceed at room temperature and are compatible with diverse functionalities, including aryl halides and thiophenes. Mechanistic studies suggest that these transformations proceed via a previously unprecedented mechanism involving two different pyridine-directed C-H activation reactions-one at a PdII center and one at PdIV.
authors.affiliation: Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109, USA.
authors.forename: Kami L
authors.initials: KL
authors.lastname: Hull
authors.forename: Erica L
authors.initials: EL
authors.lastname: Lanni
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Sanford
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D002384:Catalysis; D010084:Oxidation-Reduction
chemical_list: D001688:Biological Products