[Assessment on effects of tongjiang granule on experimental reflux esophagitis in rats].
OBJECTIVE
To study the effects of tongjiang granule (TJG) on reflux esophagitis (RE) in rats.


METHODS
Two rat models of RE were established respectively by cardioplasty + pyloric ligation + Roux-en-Y gastro-jejunum anastomosis and by placed a fixed steel ring into the gastric cardia, and the model rats were treated with various dosages of TJG or cisapride by gastric perfusion.


RESULTS
Rat models were established successfully by both methods. The score of pathological changes of esophagus mucosa in the model rats, made by either method, after high-dosage TJG treatment was lower than that in the model rats (P < 0.05), but equal to that in the cisapride treated model rats. High and moderate dosages of TJG were shown by transmission electron microscope to have effects of alleviating heckle cells and inflammatory reaction. They could reduce the level of gastric acid, more significant in high and moderate dosage groups (P < 0.05), while cisapride couldn't.


CONCLUSIONS
TJG is effective in treating experimental RE in rats to a certain extent.
Tang
Xu-dong
XD
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing. txdly@sina.com.cn
Wu
Hong-mei
HM
Wang
Zhi-bin
ZB
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004942:Esophagitis, Peptic / Q000188:drug therapy* / Q000473:pathology; D004947:Esophagus / Q000187:drug effects* / Q000473:pathology; D005260:Female; D008297:Male; D008517:Phytotherapy; D011208:Powders; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D011208:Powders; C526716:tongjiang