[Erythrocytes and leucocytes in realization of communication between lipid peroxidation and hemostasis].
Investigation of 213 rats has shown that exposition containing normal plasma of erythrocytes, neutrophils or monocytes (physiological concentration) taken from the rats treated with prooxidant (lead acetate) or antioxidant (selmevite) causes corresponding increase or decrease of: a) both spontaneous aggregation and ATP-induced aggregation of thrombocytes, b) releasing P3 and P4 factors, c) their lipoperoxidation (LPO) intensity. The effect is released by LPO products released by erythrocytes and leucocytes into their environment. The efficacy of antioxidants (vitamins with antioxidant properties in particular) used for correcting hypercoagulative changes in oxidative stress in clinics is supposed to be due to their capacity for limiting lipidoxidation in erythrocytes, leukocytes and thrombocytes.
Byshevskiĭ
A Sh
ASh
Galian
S L
SL
Ral'chenko
I V
IV
Alborov
R G
RG
Umutbaeva
M K
MK
Rudzevich
A Iu
AIu
Vinokurova
E A
EA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D009000:Monocytes / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D009942:Organometallic Compounds / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats
D000975:Antioxidants; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; C049638:dimephosphon; D000244:Adenosine Diphosphate; C008261:lead acetate