title: Inflammation but not oxidative stress is associated with beta-chemokine levels and prevalence of cardiovascular disease in uraemic patients.
abstract: Inflammation and oxidative stress (SOX) have been reported in patients with chronic renal failure (CRF), but their influence on beta-chemokines levels and cardiovascular disease (CVD) prevalence remains unknown. We assessed beta-chemokines, SOX markers and high sensitivity C-reactive protein (hs CRP) as a marker of inflammation in 40 uraemic patients, both with as well as without CVD and 20 controls. Compared with the controls, the patients with CVD showed a significant increase in plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), total peroxide (both p<0.05), macrophage inflammatory protein 1beta (MIP-1beta) and hs CRP (both p<0.01). The values of MCP-1 and hs CRP were more elevated in patients with CVD than without CVD (p<0.01 and p<0.05; respectively). Both subgroup of CRF patients were lower of regulated upon activation, normal T cell expressed and secreted (RANTES) levels than in the controls (both p<0.001). The positive relationships were between hs CRP and presence of CVD, MIP-1beta (both p<0.01) and MCP-1 levels (p<0.05). SOX markers did not show any significant correlation with beta-chemokines, hs CRP and presence of CVD. We documented that increased inflammation but not SOX were associated with significant elevation in plasma beta-chemokines levels and CVD prevalence in CRF patients not requiring dialysis.
authors.affiliation: Department of Nephrology and Clinical Transplantation, Medical University, 14 Zurawia Street, 15-540 Bialystok, Poland. krystynapawlak@poczta.onet.pl
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pawlak
authors.forename: Dariusz
authors.initials: D
authors.lastname: Pawlak
authors.forename: Michal
authors.initials: M
authors.lastname: Myśliwiec
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000276:immunology; D019742:Chemokines, CC / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000276:immunology; D014511:Uremia / Q000097:blood* / Q000150:complications / Q000276:immunology
chemical_list: D015415:Biomarkers; D019742:Chemokines, CC