title: Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain.
abstract: A series of sulphonamide derivatives (1-11) were synthesized in good yield and evaluated for their possible anticonvulsant activity and neurotoxic study. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in MES and scPTZ tests. All the compounds were less toxic than the standard drug phenytoin.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110 062, India. nadeems_03@yahoo.co.in
authors.forename: Nadeem
authors.initials: N
authors.lastname: Siddiqui
authors.forename: Surendra N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: Suroor A
authors.initials: SA
authors.lastname: Khan
authors.forename: James
authors.initials: J
authors.lastname: Stables
authors.forename: Arpana
authors.initials: A
authors.lastname: Rana
authors.forename: Mahfuz
authors.initials: M
authors.lastname: Alam
authors.forename: Md Faiz
authors.initials: MF
authors.lastname: Arshad
authors.forename: Mashooq A
authors.initials: MA
authors.lastname: Bhat
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D013449:Sulfonamides