title: [Coexpression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic carcinoma].
abstract: OBJECTIVE
  To observe the expression of Schwann cell marker GFAP and myoepithelial cell marker alpha-SMA in salivary adenoid cystic carcinoma (ACC), and to evaluate the relationship of GFAP, alpha-SMA and perineural invasion in ACC.
  
  
  METHODS
  Immunohistochemical SABC method, double-label immunofluorescence and CLSM were used to detect the expression of GFAP and alpha-SMA proteins in salivary ACC tissue samples.
  
  
  RESULTS
  In salivary ACC tissue samples, both GFAP and alpha-SMA proteins were positive, which were coexpressed in cytoplasm of the same onco-myoepithelial cells.
  
  
  CONCLUSIONS
  There may be Schwann cell differentiation in onco-myoepithelial cell of salivary ACC, and it may be the pathological base of perineural invasion in salivary ACC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Stomatology, The Fourth Military Medical University, Xi'an 710032, China. moyisun@fmmu.edu.cn
authors.forename: Mo-yi
authors.initials: MY
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Lian-jia
authors.initials: LJ
authors.lastname: Yang
authors.forename: Shao-zhong
authors.initials: SZ
authors.lastname: Dong
mesh_terms: D000199:Actins / Q000378:metabolism*; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism* / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism* / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D006801:Humans; D032342:Muscle Cells / Q000378:metabolism* / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D012583:Schwann Cells / Q000378:metabolism* / Q000473:pathology
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D005904:Glial Fibrillary Acidic Protein