Hexosaminidase as a new potential marker for middle ear cholesteatoma.
OBJECTIVE
The study aim was to investigate the activities of hexosaminidase (HEX) in cholesteatoma tissue compared with that in normal skin.


METHODS
The enzyme activities were determined using the Chatterjee et al. method in the modification of Zwierz et al. in cholesteatoma and skin.


RESULTS
Significantly higher activity of hexosaminidase was observed in cholesteatoma tissue compared with the skin.


CONCLUSIONS
Hex may be considered as a new pathogenetic factor in that destructive lesion.
Olszewska
Ewa
E
Department of Otolaryngology, Medical University, ul. Sklodowskiej 24 A, 15-274 Bialystok, Poland. ewaolsz@yahoo.com <ewaolsz@yahoo.com>
Borzym-Kluczyk
Malgorzata
M
Olszewski
Slawomir
S
Rogowski
Marek
M
Zwierz
Krzysztof
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D018424:Cholesteatoma, Middle Ear / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000378:metabolism
D015415:Biomarkers; D006596:Hexosaminidases