Insulin receptor substrate gene polymorphism is associated with obstructive sleep apnea syndrome in men.
OBJECTIVE
The objective of this study was to assess significance of insulin receptor substrate (IRS) -1 gene polymorphism (Gly972Arg) at codon 972 in obstructive sleep apnea syndrome (OSAS).


METHODS
Using the polymerase chain reaction technique, the codon 972 polymorphism of the IRS-1 gene was analyzed in the DNA obtained from leukocytes of 50 patients and 143 healthy controls.


RESULTS
An overall comparison between the genotypes and allele frequencies of the patients and controls did not reveal any statistically significant difference between the patients and controls (P > .05). Gender-specific comparisons were not significantly different except for a significant difference between the genotypes and allele frequencies of the male patients and male controls (P < .05). The heterozygous, Gly/Arg variant of the IRS-1 gene was overrepresented and the homozygous, Gly/Gly variant was less frequent in male patients compared with male controls. In the patients with OSAS, there was no correlation between the genotypes and polysomnography parameters on correlation analyses (P > .05). There was no relationship between the genotypes and diabetes mellitus (P > .05). Body mass indices and polysomnography parameters of the patients with and without diabetes mellitus were not significantly different (P > .05).


CONCLUSIONS
The polymorphism of the IRS-1 gene at codon 972, especially Gly/Arg variant, or the presence of the allele for Arg appears to be associated with occurrence of OSAS in male patients, whereas this polymorphism is not related to severity of OSAS.
Bayazit
Yildirim A
YA
Department of Otolaryngology, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey. bayazity@yahoo.com
Erdal
Mehmet Emin
ME
Yilmaz
Metin
M
Ciftci
Tansu Ulukavak
TU
Soylemez
Fatma
F
Gokdoğan
Tuba
T
Kokturk
Oguz
O
Kemaloglu
Yusuf K
YK
Koybasioglu
Ahmet
A
D000328:Adult; D001120:Arginine / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005998:Glycine / Q000235:genetics; D006801:Humans; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology
C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D010750:Phosphoproteins; D001120:Arginine; D005998:Glycine