title: Ultrasonic characterization of human cancellous bone using the Biot theory: inverse problem.
abstract: This paper concerns the ultrasonic characterization of human cancellous bone samples by solving the inverse problem using experimental transmitted signals. The ultrasonic propagation in cancellous bone is modeled using the Biot theory modified by the Johnson et al. model for viscous exchange between fluid and structure. The sensitivity of the Young modulus and the Poisson ratio of the skeletal frame is studied showing their effect on the fast and slow wave forms. The inverse problem is solved numerically by the least squares method. Five parameters are inverted: the porosity, tortuosity, viscous characteristic length, Young modulus, and Poisson ratio of the skeletal frame. The minimization of the discrepancy between experiment and theory is made in the time domain. The inverse problem is shown to be well posed, and its solution to be unique. Experimental results for slow and fast waves transmitted through human cancellous bone samples are given and compared with theoretical predictions.
authors.affiliation: Laboratorium voor Akoestiek en Thermische Fysica, Katholieke Universiteit Leuven, Celestijnenlaan 200 D, B-3001 Heverlee, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Sebaa
authors.forename: Z E A
authors.initials: ZE
authors.lastname: Fellah
authors.forename: M
authors.initials: M
authors.lastname: Fellah
authors.forename: E
authors.initials: E
authors.lastname: Ogam
authors.forename: A
authors.initials: A
authors.lastname: Wirgin
authors.forename: F G
authors.initials: FG
authors.lastname: Mitri
authors.forename: C
authors.initials: C
authors.lastname: Depollier
authors.forename: W
authors.initials: W
authors.lastname: Lauriks
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000502:physiology*; D005270:Femur Head / Q000000981:diagnostic imaging / Q000502:physiology; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010024:Osteoporosis / Q000000981:diagnostic imaging; D016012:Poisson Distribution; D016062:Porosity; D014463:Ultrasonography; D014783:Viscosity