title: [Peculiarities of lipid metabolism during pregnancy].
abstract: More than 200 mln women become pregnant every year. In most cases outcome of labor is successful. The hormonal status changes during pregnancy initiate various adaptive mechanisms. Among them is "switch" of the energetic metabolism to lipid metabolism. It undergoes essential changes. The aim of our investigation was to study the peculiarities of lipid metabolism during pregnancy. 30 pregnant patients have been investigated based on 2 stage dynamics: I stage--pregnancy period=13.0+/-1.4 weeks; II stage--pregnancy period=35.7+/-0.5 weeks. Total cholesterol, HDL, LDL, triglycerides, VLDL and Index of atherogenic risk have been measured by biochemical analysis. The parameters of lipid metabolism became significantly impaired, except HDL (40.0+/-5.8 vs. 57.5+/-9.4 mg/dl), which increased significantly. They revealed significant both direct and inverse correlations with sex hormones. Obtained results point to the body's adaptive mechanisms expressed in the increase of antiatherogenic fraction of total cholesterol; and the influence of sex hormones as well. With the increase of period of pregnancy physiological dyslipidemia became worse, which might be metabolic basis for the development of "prestage" of gall-stone--cholestasis of gall-bladder.
authors.forename: N V
authors.initials: NV
authors.lastname: Merabishvili
authors.forename: S O
authors.initials: SO
authors.lastname: Kamladze
authors.forename: G T
authors.initials: GT
authors.lastname: Sulaberidze
mesh_terms: D015243:Cholesterol, VLDL / Q000097:blood*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000453:epidemiology*; D011247:Pregnancy
chemical_list: D015243:Cholesterol, VLDL