title: Iontophoresed segmental allografts in revision arthroplasty for infection.
abstract: Revision arthroplasty after infection can often be complicated by both extensive bone loss and a relatively high rate of re-infection. Using allograft to address the bone loss in such patients is controversial because of the perceived risk of bacterial infection from the use of avascular graft material. We describe 12 two-stage revisions for infection in which segmental allografts were loaded with antibiotics using iontophoresis, a technique using an electrical potential to drive ionised antibiotics into cortical bone. Iontophoresis produced high levels of antibiotic in the allograft, which eluted into the surrounding tissues. We postulate that this offers protection from infection in the high-risk peri-operative period. None of the 12 patients who had two-stage revision with iontophoresed allografts had further infection after a mean period of 47 months (14 to 78).
authors.affiliation: Medical Engineering and Physics Department, Royal Perth Hospital, Wellington Street, Perth, Western Australia 6847, Australia.
authors.forename: K A
authors.initials: KA
authors.lastname: Michalak
authors.forename: P P C
authors.initials: PP
authors.lastname: Khoo
authors.forename: P J
authors.initials: PJ
authors.lastname: Yates
authors.forename: R E
authors.initials: RE
authors.lastname: Day
authors.forename: D J
authors.initials: DJ
authors.lastname: Wood
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000032:analysis; D019643:Arthroplasty, Replacement; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D006801:Humans; D007478:Iontophoresis / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000601:surgery; D020370:Osteoarthritis, Knee / Q000601:surgery; D011183:Postoperative Complications; D012008:Recurrence; D012086:Reoperation; D013530:Surgical Wound Infection / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents