title: The influence of total mesorectal excision on local recurrence and survival in rectal cancer patients: a population-based study in Greater Amsterdam.
abstract: OBJECTIVE
  To determine retrospectively in a population-based setting, the influence of the introduction of total mesorectal excision (TME) on local recurrence and survival in patients with rectal carcinoma.
  
  
  METHODS
  All rectal carcinomas diagnosed during 1988-1991 (979 patients, conventional surgery with blunt dissection of the rectum) and 1998-2000 (890 patients, TME resection) were selected from the Amsterdam Cancer Registry. For all patients who underwent a macroscopically radical resection in the absence of distant dissemination, information on the occurrence of local recurrent disease and distant metastasis was collected.
  
  
  RESULTS
  The cumulative 5-year recurrence rate decreased significantly from 20% for patients diagnosed in 1988-1991 to 11% in 1998-2000. Stage (T-category, nodal status), period of diagnosis (conventional surgery vs. TME resection), radiotherapy, and chemotherapy were independent variables of local recurrence in multivariate analysis. There was a non-significant trend for improved 5-year relative survival for all rectal carcinoma cases from 52% (95% CI 48-55) for patients diagnosed in 1988-1991 to 59% (95% CI 55-63) in 1998-2000.
  
  
  CONCLUSIONS
  A significant decrease in local recurrence and a trend for improved relative survival were observed. The broad introduction of TME and the shift towards preoperative radiotherapy are the most plausible explanations for these observations.
authors.affiliation: Comprehensive Cancer Centre Amsterdam, Amsterdam, The Netherlands. o.visser@ikca.nl
authors.forename: O
authors.initials: O
authors.lastname: Visser
authors.forename: R
authors.initials: R
authors.lastname: Bakx
authors.forename: F A N
authors.initials: FA
authors.lastname: Zoetmulder
authors.forename: C C
authors.initials: CC
authors.lastname: Levering
authors.forename: S
authors.initials: S
authors.lastname: Meijer
authors.forename: J F M
authors.initials: JF
authors.lastname: Slors
authors.forename: J J B
authors.initials: JJ
authors.lastname: van Lanschot
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000401:mortality; D009367:Neoplasm Staging; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery* / Q000628:therapy; D012007:Rectum / Q000528:radiation effects / Q000601:surgery*; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014798:Vital Statistics