title: Topiramate use in alprazolam addiction.
abstract: Alprazolam is successful in reducing anxiety but has a high addictive/misuse potential. Topiramate is a novel anticonvulsant which has been used as a mood stabilizer. Other anticonvulsants, such as carbamazepine and valproate, have been used in alcohol and benzodiazepine withdrawal. Topiramate has recently been used in alcohol, cocaine and opiates withdrawal. There has been also one report of topiramate use in midazolam withdrawal. In our case of a patient with recurrent major depressive disorder, subthreshold anxiety disorder and addiction to alprazolam, topiramate appears to be efficient and safe in alprazolam withdrawal.
authors.affiliation: Department of General Hospital Psychiatry, Athens University Medical School, Attikon Hospital, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Michopoulos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Douzenis
authors.forename: Christos
authors.initials: C
authors.lastname: Christodoulou
authors.forename: Lefteris
authors.initials: L
authors.lastname: Lykouras
mesh_terms: D000328:Adult; D000525:Alprazolam / Q000009:adverse effects*; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage; D001008:Anxiety Disorders / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D003511:Cyclohexanols / Q000008:administration & dosage; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D000077236:Topiramate; D016896:Treatment Outcome; D000069470:Venlafaxine Hydrochloride
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D000077236:Topiramate; D005632:Fructose; D000069470:Venlafaxine Hydrochloride; D000525:Alprazolam