title: Selection of retapamulin, a novel pleuromutilin for topical use.
abstract: The in vitro activity of retapamulin was determined and compared to that of topical and community antibiotics. The MIC(90)s of retapamulin against Staphylococcus aureus and Streptococcus pyogenes were 0.12 microg/ml and 0.016 microg/ml, respectively. Retapamulin has a low propensity to select resistance and produces an in vitro postantibiotic effect.
authors.affiliation: Department of Microbiology Research, MMPD CEDD, GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Rd, Collegeville, PA 19426-0989, USA. Stephen_Rittenhouse@GSK.com
authors.forename: Stephen
authors.initials: S
authors.lastname: Rittenhouse
authors.forename: Sanjoy
authors.initials: S
authors.lastname: Biswas
authors.forename: John
authors.initials: J
authors.lastname: Broskey
authors.forename: Lynn
authors.initials: L
authors.lastname: McCloskey
authors.forename: Terrance
authors.initials: T
authors.lastname: Moore
authors.forename: Sandra
authors.initials: S
authors.lastname: Vasey
authors.forename: Joshua
authors.initials: J
authors.lastname: West
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zalacain
authors.forename: Rimma
authors.initials: R
authors.lastname: Zonis
authors.forename: David
authors.initials: D
authors.lastname: Payne
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects; D016712:Mupirocin / Q000494:pharmacology; D011083:Polycyclic Compounds; D017192:Skin Diseases, Bacterial / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D000097567:Pleuromutilins
chemical_list: D000891:Anti-Infective Agents, Local; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004224:Diterpenes; D016712:Mupirocin; D011083:Polycyclic Compounds; D000097567:Pleuromutilins; C508887:retapamulin