[Effects of shenfu injection on immune function in patients during perioperative cardiopulmonary bypass].
OBJECTIVE
To observe the effects of Shenfu Injection (SI) on immune function in patients during perioperative cardiopulmonary bypass (CPB).


METHODS
Ninety patients scheduled for CPB were randomly divided into 3 groups, the group A treated with SI before CPB, the group B treated with SI after CPB and the group C (the control group), 30 cases in each group. Counts of leukocyte, neutrophil, lymphocyte and T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and serum levels of IgG, IgA, IgM, C3 and C4 were investigated at different time-points, i.e. one day before CPB, immediately after anesthesia and finishing CPB, and the 1st, 3rd and 8th post-operational days.


RESULTS
In all the three groups, counts of leukocyte and neutrophil rose immediately after CPB and the high level maintained on the 1st and 3rd post operational days, it somewhat lowered on the 8th day but still higher than that before operation, showing insignificant difference among the 3 groups. As for the other indexes, they declined obviously and immediately after CPB and began to restore on the 8th day to a certain extent, and the restoration were better in the group A and B, as the changes were milder.


CONCLUSIONS
SI could improve the immune function and reduce the risk of post operational infection in patients during perioperative CPB.
Chen
Xiao-wei
XW
Er-Sha Heart Center, Guangdong Provincial Hospital of TCM, Guangzhou. showvey@yahoo.com.cn
Fu
Jian
J
Ruan
Xin-min
XM
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006331:Heart Diseases / Q000276:immunology / Q000601:surgery; D006801:Humans; D007275:Injections, Intravenous; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011183:Postoperative Complications / Q000517:prevention & control*; D016176:T-Lymphocyte Subsets / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; C492793:Shen-Fu