Serotype distribution of Streptococcus pneumoniae in north-western Greece and implications for a vaccination programme.
Serotypes and antibiotic sensitivities were determined for 338 strains of Streptococcus pneumoniae from children of north-western Greece with invasive pneumococcal disease (IPD), acute otitis media (AOM) and nasopharyngeal carriage. The most common serotypes among the isolates from IPD were 14 and 19F, while 3, 19F, 9V and 14 were the major cause of AOM. In these groups, the heptavalent conjugate vaccine for pneumococci (7vPCV) seems to cover 90.5% of the serotypes isolated from children less than 2 years old. Serotypes 23F and 6B were the most prevalent in carrier strains. Overall, 23.7% of the isolates were penicillin nonsusceptible (PNS), 97% were fully susceptible to cefotaxime, 29% were resistant to erythromycin, 11.2% to co-trimoxazole and 1.2% to clindamycin.
Levidiotou
Stamatina
S
Department of Microbiology, Medical School, University of Ioannina, Ioannina, Greece. sleveidi@uoi.gr
Vrioni
Georgia
G
Tzanakaki
Georgina
G
Pappa
Christina
C
Gesouli
Helen
H
Gartzonika
Constantina
C
Papamichail
Dimitrios
D
Kremastinou
Jenny
J
D000293:Adolescent; D001428:Bacterial Vaccines / Q000276:immunology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D014611:Vaccination
D001428:Bacterial Vaccines