Expression of Sox1 during Xenopus early embryogenesis.
Sox B1 group genes, Sox1, Sox2, and Sox3 (Sox1-3), are involved in neurogenesis in various species. Here, we identified the Xenopus homolog of Sox1, and investigated its expression patterns and neural inducing activity. Sox1 was initially expressed in the anterior neural plate of Xenopus embryos, with expression restricted to the brain and optic vesicle by the tailbud stage. Expression subsequently decreased in the eye region by the tadpole stage. Sox1 expression in animal cap explants was induced by inhibition of BMP signaling in the same manner as Sox2, Sox3, and SoxD. In addition, overexpression of Sox1 induced neural markers in ventral ectoderm and in animal caps. These results implicate Xenopus Sox1 in neurogenesis, especially brain and eye development.
Nitta
Kazuhiro R
KR
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Takahashi
Shuji
S
Haramoto
Yoshikazu
Y
Fukuda
Masakazu
M
Onuma
Yasuko
Y
Asashima
Makoto
M
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D047108:Embryonic Development / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006609:High Mobility Group Proteins / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009928:Organ Specificity; D055748:SOXB1 Transcription Factors; D014018:Tissue Distribution; D029867:Xenopus Proteins / Q000378:metabolism*; D014982:Xenopus laevis / Q000196:embryology* / Q000502:physiology*
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D055748:SOXB1 Transcription Factors; C490905:Sox1 protein, Xenopus; D029867:Xenopus Proteins