Circulating levels of adiponectin in preterm infants.
OBJECTIVE
To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels.


METHODS
Prospective study.


METHODS
A university hospital neonatal care unit.


METHODS
62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group).


METHODS
Blood samples taken at discharge (40.9 (14.8) days of life) from the preterm infants and at a comparable postnatal age in full-term infants. All infants were fed the same commercial formula, but in nine preterms the formula contained long-chain polyunsaturated fatty acids (LCPUFAs).


METHODS
Serum levels of adiponectin, leptin and insulin. Associations of adiponectin levels were tested only in the preterm group.


RESULTS
Serum levels of adiponectin were lower in preterm (40.9 (14.8) microg/ml) than full-term infants (53.1 (16.0) microg/ml, p<0.01). However, after adjustment for body weight, the influence of prematurity on adiponectin levels was no longer significant. In preterm infants, adiponectin levels independently correlated with being born small for gestational age (SGA) (beta=-0.35, p=0.01), weight gain (beta=0.28, p=0.03) and LCPUFA-supplemented formula (beta=0.34, p=0.009). Serum adiponectin levels did not correlate with insulin or leptin levels. However, insulin levels were higher in preterm than in full-term infants after adjustment for body weight.


CONCLUSIONS
Adiponectin levels are lower in preterm infants at discharge than full-term infants probably due to decreased adiposity. The levels are influenced by being born SGA, weight gain and, possibly, by dietary LCPUFAs. The importance of these findings in the development of insulin or leptin resistance in children born prematurely needs to be further studied.
Siahanidou
Tania
T
First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, 115 27 Athens, Greece. neonat5@paidon-agiasofia.gr
Mandyla
Helen
H
Papassotiriou
Gerasimos-Peter
GP
Papassotiriou
Ioannis
I
Chrousos
George
G
D052242:Adiponectin / Q000097:blood*; D000886:Anthropometry / Q000379:methods; D001724:Birth Weight / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D011446:Prospective Studies; D015430:Weight Gain / Q000502:physiology
D052242:Adiponectin; D007328:Insulin; D020738:Leptin