Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension.
BACKGROUND
The purpose of the study was to use factor analysis to investigate the contribution of a directly measured insulin sensitivity index, steady-state plasma glucose (SSPG) from insulin suppression test (IST), to a clustering of cardiovascular risk factors in hypertensive subjects.


METHODS
A total of 204 nondiabetic hypertensive patients who received IST for SSPG were included for current analysis. Factor analysis was performed to explore the contribution of SSPG as additional information to a clustering of risk factors in these subjects.


RESULTS
In factor analysis, SSPG aggregated with metabolic variables in an obesity-hyperinsulinemia domain that included two factors: one with positive loadings for SSPG, 2-h glucose, and Log 2-h insulin; and the other with positive loadings for body mass index, waist circumference, and fasting glucose. Fasting insulin linked the two factors together and explained 38.3% of the total variance. Systolic and diastolic blood pressures were loaded on a blood pressure domain separately. The third domain consisted of two factors: one with positive loadings for Log triglycerides and negative loading for high-density lipoprotein cholesterol; and the other with positive loadings for Log triglycerides and non-high-density lipoprotein cholesterol. The model loaded without SSPG explained a proportion of the total variance (78.5%) similar to that achieved with the model loaded with SSPG (77.1%).


CONCLUSIONS
Directly measured insulin sensitivity index SSPG clustered with 2-h glucose and Log 2-h insulin in factor analysis in a cohort consisting entirely of hypertensive subjects. However, the contribution of SSPG as additional information to explain the total variance seems to be insignificant.
Lin
Ming-Wei
MW
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Hwu
Chii-Min
CM
Huang
Yung-Hsiang
YH
Sheu
Wayne H-H
WH
Shih
Kuang-Chung
KC
Chiang
Fu-Tien
FT
Olshen
Richard
R
Chen
Yii-Der I
YD
Curb
J David
JD
Rodriguez
Beatriz
B
Ho
Low-Tone
LT
D000328:Adult; D001213:Asian; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D002320:Cardiovascular Physiological Phenomena; D015331:Cohort Studies; D005163:Factor Analysis, Statistical; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity; D018570:Risk Assessment; D012307:Risk Factors
D001786:Blood Glucose