title: Detection of impaired coronary flow reserve in coronary artery disease using transthoracic echocardiographic assessment of coronary sinus blood flow.
abstract: In order to establish whether coronary flow reserve (CFR) can be measured by transthoracic echocardiography (TTE) with pulse wave Doppler echocardiography, 14 patients with coronary artery disease (CAD) and 12 normal subjects were studied. Coronary sinus blood flow was measured at rest and 2 minutes after intravenous injection of 0.56 mg/kg dipyridamole (DP). CFR was calculated as the DP to rest flow ratio. Patients with CAD were found to have significantly decreased CFR when compared to normal subjects. These findings suggest that TTE may be useful in diagnosing CAD.
authors.affiliation: Division of Cardiology, LAC & USC Medical Center, USC Keck School of Medicine, Los Angeles, California, USA.
authors.forename: Ghasan M
authors.initials: GM
authors.lastname: Tabel
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vlachonassios
authors.forename: Mohammed
authors.initials: M
authors.lastname: Tabel
authors.forename: Houman
authors.initials: H
authors.lastname: Vaghafi
authors.forename: Niveen
authors.initials: N
authors.lastname: Abdelmessih
authors.forename: P Anthony
authors.initials: PA
authors.lastname: Chandraratna
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects; D016022:Case-Control Studies; D003326:Coronary Circulation / Q000187:drug effects; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004176:Dipyridamole; D004452:Echocardiography; D018619:Echocardiography, Doppler, Pulsed; D006801:Humans; D007275:Injections, Intravenous; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D004176:Dipyridamole