title: Animal models of arterial stiffness.
abstract: Animal models of large artery wall stiffness fall into two categories: firstly those that slowly develop multifactorial vascular dysfunction spontaneously, such as the ageing rat. The second type of model consists of those in which a specific pathology is induced by surgical, chemical, or genetic means. Such models are based on a short-term, highly traumatic insult to the arterial wall of a young animal and its acute reaction to such insult. This is very different from the human situation in which changes in wall stiffness arise from the long-term accumulation of relatively minor episodes of vascular insult in the vulnerable elderly.
authors.affiliation: Pharmacology Laboratory, Pharmacy Faculty, UHP-Nancy, Nancy , France.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Atkinson
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D002114:Calcinosis / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D003094:Collagen / Q000502:physiology; D004195:Disease Models, Animal; D004549:Elastin / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology; D010196:Pancreatic Elastase / Q000627:therapeutic use; D012084:Renin-Angiotensin System / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects / Q000235:genetics
chemical_list: D018377:Neurotransmitter Agents; D003094:Collagen; D004549:Elastin; D010196:Pancreatic Elastase