Global cerebral blood flow in relation to cognitive performance and reserve in subjects with mild memory deficits.
OBJECTIVE
This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET).


METHODS
Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 +/- 6.2 years) meeting criteria for mild cognitive impairment (MCI). PET consisted of quantitative [(15)O]water determinations of CBF, two at baseline and one postadministration of acetazolamide (ACZ).


RESULTS
Mean gCBF were 44.9 +/- 5.5 during counting, 44.5 +/- 6.7 for the memory task, and 60.2 +/- 4.8 ml/min/100 g for post-ACZ (CVR of 33.9 +/- 13.2%). Task-related gCBF change was significantly related to memory score, performance on the Trail Making Test B (Trails-B), premorbid IQ, and education, and differed significantly between the learning-based groups.


CONCLUSIONS
Cognitive reserve appears analogous to cardiac reserve. The ability to alter gCBF paralleled performance on general cognitive measures, was enhanced in higher levels of cognitive reserve, and was impaired in individuals who no longer appear to benefit from repeated exposure to testing.
Boles Ponto
Laura L
LL
Positron Emission Tomography Imaging Center, Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa, IA 52242, USA. laura-ponto@uiowa.edu
Magnotta
Vincent A
VA
Moser
David J
DJ
Duff
Kevin M
KM
Schultz
Susan K
SK
D000086:Acetazolamide / Q000627:therapeutic use*; D000368:Aged; D001519:Behavior; D002531:Cerebellum / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000379:methods*; D012189:Retrospective Studies; D014706:Verbal Learning / Q000187:drug effects
D000086:Acetazolamide