title: Comparison of coronary restenosis rates in matched patients with versus without diabetes mellitus.
abstract: Diabetes mellitus (DM) is an established risk factor for stent restenosis, in part as a result of the smaller vessel dimensions and longer lesions. This study compared the magnitude of acute lumen gain and late lumen loss after elective coronary stent implantation in patients with and without DM using a matched-pair analysis. A total of 133 patients with DM and 192 coronary lesions were included in this analysis. A group of 192 lesions in 182 patients without DM were matched in a pairwise fashion, stratifying for reference diameter, minimal luminal diameter, and lesion length. The binary restenosis rate at the 5-month follow-up angiography was 25% in the DM group and 14% in the non-DM group (p <0.01). Acute angiographic lumen gain (1.47 +/- 0.41 vs 1.56 +/- 0.38 mm, p = 0.03) and late lumen loss (0.64 +/- 0.42 vs 0.55 +/- 0.36 mm, p = 0.02) were significantly different between the DM and non-DM groups. In conclusion, suboptimal acute procedural results and an exaggerated neointimal proliferation contributed by about 50% to the lower net lumen gain in the DM group. Patients with DM had a significantly higher restenosis rate even when matched for preprocedural angiographic lesion dimensions. Mechanistically, inferior procedural results, as well as exaggerated neointimal proliferation, are, quantitatively, equally important in this process.
authors.affiliation: Medical Clinic II, University of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. radke@innere2.uni-luebeck.de
authors.forename: Peter W
authors.initials: PW
authors.lastname: Radke
authors.forename: Klara
authors.initials: K
authors.lastname: Friese
authors.forename: Andrea
authors.initials: A
authors.lastname: Buhr
authors.forename: Bernard
authors.initials: B
authors.lastname: Nagel
authors.forename: Lars-Christian
authors.initials: LC
authors.lastname: Harland
authors.forename: Axel
authors.initials: A
authors.lastname: Kaiser
authors.forename: Marko
authors.initials: M
authors.lastname: Remmel
authors.forename: Peter
authors.initials: P
authors.lastname: Hanrath
authors.forename: Heribert
authors.initials: H
authors.lastname: Schunkert
authors.forename: Rainer
authors.initials: R
authors.lastname: Hoffmann
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D023921:Coronary Stenosis / Q000628:therapy; D048909:Diabetes Complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome