Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).
Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial recognition test and Morris water maze. Peptides HLDF-6 and PEDF-6 possessed neuroprotective activity and counteracted the toxic effect of Abeta(25-35). Peptides HLDF-6 and PEDF-6 mainly improved long-term memory and working memory, respectively.
Storozheva
Z I
ZI
Laboratory of Neurochemistry, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences.
Proshin
A T
AT
Zhokhov
S S
SS
Sherstnev
V V
VV
Rodionov
I L
IL
Lipkin
V M
VM
Kostanyan
I A
IA
D016229:Amyloid beta-Peptides / Q000008:administration & dosage*; D000818:Animals; D005136:Eye Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000494:pharmacology*; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D015843:Serpins / Q000008:administration & dosage / Q000494:pharmacology*; D000099174:Pigment Epithelium-Derived Factor
D016229:Amyloid beta-Peptides; D005136:Eye Proteins; D009414:Nerve Growth Factors; D009842:Oligopeptides; D010446:Peptide Fragments; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor; C074636:amyloid beta-protein (25-35); C513648:threonyl-glycyl-glutamyl-asparaginyl-histidylarginine