Gymnastatins F-H, cytostatic metabolites from the sponge-derived fungus Gymnascella dankaliensis.
Gymnastatins F -H (2-4) and gymnamide (5) have been isolated from the mycelial MeOH extract of the Halichondria sponge-derived fungus Gymnascella dankaliensis. Their stereostructures have been established on the basis of spectroscopic analyses using 1D and 2D NMR techniques. The stereochemistry of gymnastatin H (4) was determined by its synthesis. Among these compounds, gymnastatins F (2) and G (3) possess a unique bicyclo[3.3.1]nonane ring as natural products, and they were found to exhibit potent growth inhibition against the P388 cancer cell line.
Amagata
Taro
T
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094 Japan.
Minoura
Katsuhiko
K
Numata
Atsushi
A
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007564:Japan; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology
D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D010636:Phenols; C515174:gymnastatin F; C515176:gymnastatin G; C515175:gymnastatin H