Antimicrobial properties of nuclear diffusion inhibitory signal of HIV-1 Rev.
Nuclear Diffusion Inhibitory Signal (NIS) has been identified in human immunodeficiency virus type 1 (HIV-1) Rev as a nuclear signal peptide which modulates nucleocytoplasmic protein trafficking and intracellular stability of the HIV-1 Rev. In this study, it was discovered that antimicrobial properties are inherent in the NIS. This is a significant finding that the NIS, which does not exist solely for self defense, in fact possesses antimicrobial properties.
Kobayashi
Nahoko
N
Nagoya R&D Institute, Toagosei Co., Ltd., Nagoya, 455-0027 Japan.
Yoshida
Tetsuhiko
T
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002467:Cell Nucleus / Q000378:metabolism*; D015694:Gene Products, rev / Q000235:genetics / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D019913:Nuclear Localization Signals / Q000235:genetics* / Q000502:physiology; D054321:rev Gene Products, Human Immunodeficiency Virus
D000900:Anti-Bacterial Agents; D015694:Gene Products, rev; D019913:Nuclear Localization Signals; D054321:rev Gene Products, Human Immunodeficiency Virus; C514860:rev protein, Human Immunodeficiency Virus-1