title: 5'-methylaristeromycin and related derivatives.
abstract: The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytotoxicity caused ostensibly by the intracellular formation of its 5'-nucleotide derivatives. Aristeromycin derivatives that offered steric interference to this transformation at the C-5' center were sought. This paper describes the facile stereospecific synthesis, where necessary, of such C-5'-methylated aristeromycin derivatives.
authors.affiliation: Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849-5312, USA. schnest@auburn.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Ye
authors.forename: Stewart W
authors.initials: SW
authors.lastname: Schneller
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D003517:Cyclopentanes / Q000737:chemistry; D015394:Molecular Structure
chemical_list: C521697:5'-methylaristeromycin; D000998:Antiviral Agents; D003517:Cyclopentanes; C030034:aristeromycin; D000241:Adenosine