title: Water soluble complexes of chitosan-g-MPEG and hyaluronic acid.
abstract: Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS-g-MPEG) and negatively charged hyaluronic acid (HA). CS-g-MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG-aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS-g-MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS-g-MPEG solution. The highest viscosity was obtained when the charge ratio of CS-g-MPEG/HA was close to 1.0. Small-angle X-ray scattering measurements provided some insights into the lamellar structure of the CS-g-MPEG/HA complex. The CS-g-MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium).
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Xuefen
authors.initials: X
authors.lastname: Wang
authors.forename: Jong Kahk
authors.initials: JK
authors.lastname: Keum
authors.forename: Hongwen
authors.initials: H
authors.lastname: Zhou
authors.forename: Mikhail
authors.initials: M
authors.lastname: Gelfer
authors.forename: Carlos-Alberto
authors.initials: CA
authors.lastname: Avila-Orta
authors.forename: Hui
authors.initials: H
authors.lastname: Pan
authors.forename: Weiliam
authors.initials: W
authors.lastname: Chen
authors.forename: Shu-Min
authors.initials: SM
authors.lastname: Chiao
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Hsiao
authors.forename: Benjamin
authors.initials: B
authors.lastname: Chu
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D015394:Molecular Structure; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013696:Temperature; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D014867:Water; D011092:Polyethylene Glycols; D006820:Hyaluronic Acid; C028210:monomethoxypolyethylene glycol; D048271:Chitosan