title: Left ventricular remodeling after anterior wall acute myocardial infarction in modern clinical practice (from the REmodelage VEntriculaire [REVE] study group).
abstract: Left ventricular (LV) remodeling after acute myocardial infarction (AMI) has been well described in previous studies. However, there is a paucity of data on the incidence of and risk factors for LV remodeling in modern clinical practice that incorporates widespread use of acute reperfusion strategies and almost systematic use of "antiremodeling" medications, such as angiotensin-converting enzyme inhibitors and beta blockers. We enrolled 266 patients with anterior wall Q-wave AMI who had >or=3 segments of the infarct zone that were akinetic on echocardiography before discharge. Echocardiographic follow-up was performed 3 months and 1 year after AMI. LV volumes, ejection fraction, wall motion score index, and mitral flow velocities were determined in a blinded analysis at a core echocardiographic laboratory. Acute reperfusion was attempted in 220 patients (83%; primary angioplasty in 29% and thrombolysis in 54%). During hospitalization, 99% of patients underwent coronary angiography and 87% underwent coronary stenting of the infarct-related lesion. At 1 year, 95% of patients received an antiplatelet agent, 89% a beta blocker, 93% an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, and 93% a statin. Echocardiographic follow-up was obtained in 215 patients. There was recovery in LV systolic function as shown by a decrease in wall motion score index and an increase in ejection fraction. There was a significant increase in end-diastolic volume (EDV; 56.4 +/- 14.7 ml/m2 at baseline, 59.3 +/- 15.7 ml/m2 at 3 months, 62.8 +/- 18.7 ml/m2 at 1 year, p <0.0001). LV remodeling (>20% increase in EDV) was observed in 67 patients (31%). Peak creatine kinase level, systolic blood pressure, and wall motion score index were independently associated with changes in EDV. In conclusion, recent improvements in AMI management do not abolish LV remodeling, which remains a relatively frequent event after an initial anterior wall AMI.
authors.affiliation: Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Savoye
authors.forename: Octave
authors.initials: O
authors.lastname: Equine
authors.forename: Olivier
authors.initials: O
authors.lastname: Tricot
authors.forename: Olivier
authors.initials: O
authors.lastname: Nugue
authors.forename: Benoit
authors.initials: B
authors.lastname: Segrestin
authors.forename: Karine
authors.initials: K
authors.lastname: Sautière
authors.forename: Mariam
authors.initials: M
authors.lastname: Elkohen
authors.forename: Eduard Matei
authors.initials: EM
authors.lastname: Pretorian
authors.forename: Kouroch
authors.initials: K
authors.lastname: Taghipour
authors.forename: André
authors.initials: A
authors.lastname: Philias
authors.forename: Valérie
authors.initials: V
authors.lastname: Aumégeat
authors.forename: Eric
authors.initials: E
authors.lastname: Decoulx
authors.forename: Pierre V
authors.initials: PV
authors.lastname: Ennezat
authors.forename: Christophe
authors.initials: C
authors.lastname: Bauters
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity; D001794:Blood Pressure; D017023:Coronary Angiography; D003326:Coronary Circulation; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006339:Heart Rate; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D015425:Myocardial Reperfusion; D015588:Observer Variation; D011446:Prospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D020257:Ventricular Remodeling