title: Presence of the exoU gene of Pseudomonas aeruginosa is correlated with cytotoxicity in MDCK cells but not with colonization in BALB/c mice.
abstract: A total of 141 independent strains of Pseudomonas aeruginosa with different heterogeneities in the exo gene (exoS, exoT, exoU, and exoY) background were examined for their pathogenic roles. Results indicated that the exoU gene is the major contributor to cytotoxicity in Madin-Darby canine kidney cells but is not related to bacterial colonization in mice.
authors.affiliation: Department of Infectious Disease, E-DA Hospital/I-Shou University, Kaoshiung, Taiwan.
authors.forename: Hsi-Hsun
authors.initials: HH
authors.lastname: Lin
authors.forename: Shiao-ping
authors.initials: SP
authors.lastname: Huang
authors.forename: Hsiu-Chen
authors.initials: HC
authors.lastname: Teng
authors.forename: Dar-Der
authors.initials: DD
authors.lastname: Ji
authors.forename: Yao-Shen
authors.initials: YS
authors.lastname: Chen
authors.forename: Ya-Lei
authors.initials: YL
authors.lastname: Chen
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D016923:Cell Death; D002460:Cell Line; D004195:Disease Models, Animal; D004285:Dogs; D005798:Genes, Bacterial; D051379:Mice; D008807:Mice, Inbred BALB C; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors; C111749:pseudomonas exoprotein A protein, Pseudomonas aeruginosa