title: Topical tacrolimus neither prevents nor abolishes ultraviolet-induced erythema.
abstract: A dose- and vehicle-controlled study on the pretreatment and posttreatment effect of 0.1% tacrolimus ointment on erythema induced by solar-simulated ultraviolet (UV) radiation was performed. Surprisingly, comparisons of clinical erythema scores and colorimetric data obtained 24 and 72 hours after UV exposure did not reveal significant differences between the control, tacrolimus, and vehicle preirradiation and postirradiation treated sites (P > .05). Our data strongly indicate that topical tacrolimus neither prevents nor abolishes UV-induced erythema in a clinical meaningful degree.
authors.affiliation: Department of Dermatology, Ruhr-University Bochum, Bochum, Germany. t.gambichler@klinikum-bochum.de
authors.forename: Thilo
authors.initials: T
authors.lastname: Gambichler
authors.forename: Nordwig S
authors.initials: NS
authors.lastname: Tomi
authors.forename: Georg
authors.initials: G
authors.lastname: Moussa
authors.forename: Julia
authors.initials: J
authors.lastname: Huyn
authors.forename: Heinrich
authors.initials: H
authors.lastname: Dickel
authors.forename: Peter
authors.initials: P
authors.lastname: Altmeyer
authors.forename: Alexander
authors.initials: A
authors.lastname: Kreuter
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016559:Tacrolimus / Q000008:administration & dosage* / Q000627:therapeutic use; D017211:Treatment Failure; D014466:Ultraviolet Rays
chemical_list: D000893:Anti-Inflammatory Agents; D016559:Tacrolimus