title: First highly stereoselective synthesis of anti-alpha-trifluoromethyl-beta-amino acid derivatives.
abstract: The Reformatsky-type reaction of 2-bromo-3,3,3-trifluoropropanoic imide with various types of imines, in the presence of ZnBr2 as a Lewis acid in THF at 0 degrees C for 3 h, gave the corresponding alpha-trifluoromethyl-beta-amino acid derivatives in a highly anti-selective manner.
authors.affiliation: Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-8585, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Shimada
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Konno
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishihara
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D007094:Imides / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007094:Imides; D007097:Imines