Metabolic correction reduces the area of acute ischemic myocardial infarction in rats.
The possibility of decreasing the degree of irreversible alterations in cardiomyocytes with original saline reperfusion solution enriched with L-aspartic acid, D-glucose, and Dmannitol was studied on experimental rats with regional ischemia and reperfusion. Infusion of the test solution into the left ventricle during the early reperfusion stage significantly reduced the area of myocardial infraction. This effect was accompanied by improvement of energy metabolism and decrease in damage to cell membranes in the risk zone. Our results indicate that metabolic protection during reperfusion increases myocardial resistance to ischemic and reperfusion stress.
Pisarenko
O I
OI
Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Center, Moscow. olpi@cardio.ru
Serebryakova
L I
LI
Studneva
I M
IM
Tskitishvili
O V
OV
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000378:metabolism; D009203:Myocardial Infarction / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism*; D015425:Myocardial Reperfusion; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions
D012996:Solutions; D001224:Aspartic Acid; D008353:Mannitol; D005947:Glucose