title: Reliability of the ICRP'S dose coefficients for members of the public: IV. basis of the human alimentary tract model and uncertainties in model predictions.
abstract: The biokinetic and dosimetric model of the gastrointestinal (GI) tract applied in current documents of the International Commission on Radiological Protection (ICRP) was developed in the mid-1960s. The model was based on features of a reference adult male and was first used by the ICRP in Publication 30, Limits for Intakes of Radionuclides by Workers (Part 1, 1979). In the late 1990s an ICRP task group was appointed to develop a biokinetic and dosimetric model of the alimentary tract that reflects updated information and addresses current needs in radiation protection. The new age-specific and gender-specific model, called the Human Alimentary Tract Model (HATM), has been completed and will replace the GI model of Publication 30 in upcoming ICRP documents. This paper discusses the basis for the structure and parameter values of the HATM, summarises the uncertainties associated with selected features and types of predictions of the HATM and examines the sensitivity of dose estimates to these uncertainties for selected radionuclides. Emphasis is on generic biokinetic features of the HATM, particularly transit times through the lumen of the alimentary tract, but key dosimetric features of the model are outlined, and the sensitivity of tissue dose estimates to uncertainties in dosimetric as well as biokinetic features of the HATM are examined for selected radionuclides.
authors.affiliation: Oak Ridge National Laboratory, 1060 Commerce Park, 37831 Oak Ridge, TN, USA. rwl@ornl.gov
authors.forename: R
authors.initials: R
authors.lastname: Leggett
authors.forename: J
authors.initials: J
authors.lastname: Harrison
authors.forename: A
authors.initials: A
authors.lastname: Phipps
mesh_terms: D004307:Dose-Response Relationship, Radiation; D041981:Gastrointestinal Tract / Q000528:radiation effects*; D017408:Guidelines as Topic; D007390:International Agencies; D008954:Models, Biological; D011829:Radiation Dosage; D011835:Radiation Protection / Q000592:standards*; D011874:Radiometry / Q000592:standards*; D018570:Risk Assessment / Q000592:standards; D012307:Risk Factors