Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is emerging as a major cause of chronic liver disease in association with the rising prevalence of obesity and type 2 diabetes in the population. Oxidative stress and insulin resistance (IR) are major contributors in the pathogenesis of NAFLD and in the progression from steatosis to steatohepatitis. Recently, Houstis and colleagues reported that reactive oxygen species have a causal role in multiple forms of IR, a phenomenon that can further promote exacerbation of oxidative stress. The improvement of the knowledge of these interrelationships should contribute to elucidate pathogenic pathways and design effective treatments for NAFLD.
Videla
Luis A
LA
Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago-7, Chile. videla@med.uchile.cl
Rodrigo
Ramón
R
Araya
Julia
J
Poniachik
Jaime
J
D016207:Cytokines / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009765:Obesity / Q000150:complications / Q000378:metabolism; D018384:Oxidative Stress; D015398:Signal Transduction
D016207:Cytokines; D005231:Fatty Acids, Unsaturated; D018836:Inflammation Mediators