Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain.
A series of sulphonamide derivatives (1-11) were synthesized in good yield and evaluated for their possible anticonvulsant activity and neurotoxic study. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in MES and scPTZ tests. All the compounds were less toxic than the standard drug phenytoin.
Siddiqui
Nadeem
N
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110 062, India. nadeems_03@yahoo.co.in
Pandeya
Surendra N
SN
Khan
Suroor A
SA
Stables
James
J
Rana
Arpana
A
Alam
Mahfuz
M
Arshad
Md Faiz
MF
Bhat
Mashooq A
MA
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000927:Anticonvulsants; D013449:Sulfonamides