title: BMP4 expression in the developing rat retina.
abstract: We investigated the expression of bone morphogenetic protein-4 (BMP4) in the developing retina. At E19, we found very intense BMP4 immunoreactivity (IR) in the nerve fiber layer. At P1, the inner plexiform layer exhibited very strong BMP4-IR. Thereafter, abundant BMP4 expression was kept to the adult period. These results suggest that BMP4 plays pivotal roles in the retina not only in the early embryonic period but also in the late embryonic and postnatal periods, and even in the adult.
authors.affiliation: Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Sumiko
authors.initials: S
authors.lastname: Mikawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hotta
authors.forename: Kohji
authors.initials: K
authors.lastname: Sato
mesh_terms: D000818:Animals; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000166:cytology / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: C525811:Bmp4 protein, rat; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins