Synthesis of osteoconductive organic inorganic nanohybrids through modification of chitin with alkoxysilane and calcium chloride.
The so-called bioactive ceramics have been attractive because they spontaneously bond to living bone. Organic-inorganic hybrids consisting of organic polymers and the essential constituents of the bioactive ceramics, i.e., silanol (Si-OH) group and calcium ions (Ca(2+)), are useful as novel bone substitutes, owing to bioactivity and high flexibility. In the present study, organic-inorganic hybrids are synthesized from chitin by modification with glycidoxypropyltrimethoxysilane (GPS) and calcium chloride (CaCl(2)). Their apatite-forming ability is examined in a simulated body fluid (SBF). The prepared hybrids form apatite on their surfaces in SBF within 7 days.
Miyazaki
Toshiki
T
Graduate School of Life Science and Systems Engineering Kyushu Institute of Technology, 2-4 Hibikino, Kitakyushu, Japan. tmiya@life.kyutech.ac.jp
Ohtsuki
Chikara
C
Ashizuka
Masahiro
M
D001031:Apatites / Q000138:chemical synthesis / Q000737:chemistry; D001826:Body Fluids; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry*; D002516:Ceramics / Q000138:chemical synthesis / Q000737:chemistry; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry*; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D001031:Apatites; D018786:Bone Substitutes; D012821:Silanes; D002686:Chitin; D002122:Calcium Chloride