title: Chronic (-)-deprenyl administration attenuates dendritic developmental impairment induced by early social isolation in the rat.
abstract: It has been demonstrated that postweaning social isolation alters dendritic development in the medial prefrontal cortex (mPFC) of the rat. In addition, (-)-deprenyl, a monoamine oxidase B (MAO-B) inhibitor, promotes dendritic growth in prefrontocortical pyramidal cells. This study examined whether prefrontocortical dendritic developmental impairment induced by postweaning social isolation is attenuated by chronic (-)-deprenyl administration. Weanling Sprague-Dawley male rats were randomly reared in social and isolated environments between postnatal days 21 and 51 (P21-P51). At P52, half of the animals were behaviorally evaluated in the open-field test and sacrificed for histological analysis. The remaining isolated rats were subdivided into saline- and daily (-)-deprenyl-treated animals for 30 additional days (P52-P82). Socially-reared rats remained undisturbed except for daily saline administration. At P82, all animals were behaviorally evaluated and sacrificed for histological analysis. Dendritic quantification of the Golgi-Cox-Sholl-stained neurons indicated that chronic (-)-deprenyl administration partially compensated the dendritic growth impairment induced by social isolation. In addition, both isolated-saline- and (-)-deprenyl-treated rats showed a sustained locomotor hyperactivity in the open-field test.
authors.affiliation: Instituto de Ciencias Básicas, Universidad Católica del Maule, Talca, Chile. rpascual@ucm.cl
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Pascual
authors.forename: S Pilar
authors.initials: SP
authors.lastname: Zamora-León
mesh_terms: D000818:Animals; D048430:Cell Shape / Q000187:drug effects; D003712:Dendrites / Q000187:drug effects* / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D017397:Prefrontal Cortex / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D017966:Pyramidal Cells / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D012642:Selegiline / Q000494:pharmacology*; D012934:Social Isolation
chemical_list: D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline