title: Peri-infarct ischemia determined by cardiovascular magnetic resonance evaluation of myocardial viability and stress perfusion predicts future cardiovascular events in patients with severe ischemic cardiomyopathy.
abstract: BACKGROUND
  We assessed whether cardiovascular magnetic resonance imaging (CMR) of peri-infarct ischemia provides prognostic information in severe ischemic cardiomyopathy (ICM) patients referred for revascularization.
  
  
  METHODS
  Twenty-one patients with severe ICM were recruited prospectively for combined stress adenosine perfusion, late gadolinium enhancement, and rest perfusion studies. The patients were followed for in-hospital and post-discharge cardiovascular events.
  
  
  RESULTS
  During 12+/- 9.8 months follow-up, 67% of the patients with peri-infarct ischemia and 13% of the patients without peri-infarct ischemia had cardiovascular events (p = 0.03). CONCLUSION. In severe ICM patients, the presence of peri-infarct ischemia was associated with a higher incidence of cardiovascular events.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California, USA.
authors.forename: Miwako
authors.initials: M
authors.lastname: Tsukiji
authors.forename: Patricia
authors.initials: P
authors.lastname: Nguyen
authors.forename: Girish
authors.initials: G
authors.lastname: Narayan
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Hellinger
authors.forename: Frandics
authors.initials: F
authors.lastname: Chan
authors.forename: Robert
authors.initials: R
authors.lastname: Herfkens
authors.forename: John M
authors.initials: JM
authors.lastname: Pauly
authors.forename: Michael V
authors.initials: MV
authors.lastname: McConnell
authors.forename: Phillip C
authors.initials: PC
authors.lastname: Yang
mesh_terms: D000241:Adenosine; D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000473:pathology; D003287:Contrast Media; D003326:Coronary Circulation; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology*; D017202:Myocardial Ischemia / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D014665:Vasodilator Agents
chemical_list: D003287:Contrast Media; D014665:Vasodilator Agents; D019786:Gadolinium DTPA; D000241:Adenosine