An organic selenium compound attenuates apomorphine-induced stereotypy in mice.
Selenium compounds display neuroprotective activities mediated at least in part by their antioxidant actions. Oxidative damage has been implicated in psychiatric disorders including schizophrenia and bipolar disorder, and an alteration in expression of selenium-binding protein-1 (SELENBP-1) has been recently reported in both the blood and brain of schizophrenic patients. In the present study we examined the effects of the organic selenium compound 3'3-ditrifluoromethyldiphenyl diselenide [(F3CPhSe)2] on apomorphine-induced stereotypy in mice, an animal model of psychosis. Systemic administration of (F3CPhSe)2 at the highest dose used (25.0 micromol/kg in a 10.0 ml/kg injection volume) significantly reduced apomorphine-induced stereotyped behaviors. A series of control experiments showed that the same dose of (F3CPhSe)2 did not affect open-field behavior, habituation, or aversively motivated memory. The results indicate that organic selenium compounds should be further investigated as agents with possible antipsychotic properties.
Machado
Miriana S
MS
Graduate Program in Cellular and Molecular Biology and Center for Biotechnology, Federal University of Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil. miriana@cbiot.ufrgs.br
Rosa
Renato M
RM
Dantas
Andrea S
AS
Reolon
Gustavo K
GK
Appelt
Helmóz R
HR
Braga
Antônio Luiz
AL
Henriques
João Antonio Pêgas
JA
Roesler
Rafael
R
D000704:Analysis of Variance; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005106:Exploratory Behavior / Q000502:physiology; D008297:Male; D051379:Mice; D016566:Organoselenium Compounds / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*
C517388:3',3-ditrifluoromethyldiphenyl diselenide; D018491:Dopamine Agonists; D016566:Organoselenium Compounds; D001058:Apomorphine