Molecular mechanisms for regulation of AMPAR trafficking by PICK1.
AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor trafficking is a fundamental mechanism for regulating synaptic strength, and hence may underlie cellular processes involved in learning and memory. PICK1 (protein that interacts with protein C-kinase) has recently emerged as a key regulator of AMPAR (AMPA receptor) traffic, and the precise molecular mechanisms of PICK1's action are just beginning to be unravelled. In this review, I summarize recent findings that describe some important molecular characteristics of PICK1 with respect to AMPAR cell biology.
Hanley
J G
JG
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK. Jon.Hanley@bristol.ac.uk
D000494:Allosteric Regulation; D000818:Animals; D002118:Calcium / Q000502:physiology; D020013:Calcium Signaling; D002352:Carrier Proteins / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D006706:Homeostasis; D017774:Long-Term Potentiation; D036881:Long-Term Synaptic Depression; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000502:physiology*; D011487:Protein Conformation; D021381:Protein Transport; D018091:Receptors, AMPA / Q000378:metabolism / Q000502:physiology*
D002352:Carrier Proteins; D009687:Nuclear Proteins; D018091:Receptors, AMPA; D002118:Calcium