title: Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice.
abstract: Nicotine is known to decrease body weight in normal rodents and human smokers, whereas nicotine withdrawal or smoking cessation can increase body weight. We have found that mice fed a high fat diet do not show the anorectic effect of chronic nicotine treatment, but do increase their body weight following nicotine withdrawal. Nicotine withdrawal is accompanied by increased expression of the orexigenic peptides neuropeptide Y and Agouti-related protein in the hypothalamus, and decreased expression of the metabolic protein uncoupling protein-3 in brown adipose tissue. These data suggest that diet can influence the ability of nicotine to modulate body weight regulation and demonstrate that chronic nicotine exposure results in adaptive changes in central and peripheral molecules which regulate feeding behavior and energy metabolism.
authors.affiliation: Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Fornari
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pedrazzi
authors.forename: Giordano
authors.initials: G
authors.lastname: Lippi
authors.forename: Marina R
authors.initials: MR
authors.lastname: Picciotto
authors.forename: Michele
authors.initials: M
authors.lastname: Zoli
authors.forename: Isabella
authors.initials: I
authors.lastname: Zini
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D054366:Agouti Signaling Protein; D054369:Agouti-Related Protein; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology*; D004041:Dietary Fats / Q000008:administration & dosage; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D024101:Mitochondrial Proteins / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism*; D009538:Nicotine / Q000008:administration & dosage / Q000009:adverse effects*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D011943:Receptors, Adrenergic, beta / Q000235:genetics / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D000071247:Uncoupling Protein 3
chemical_list: C515198:AGRP protein, human; D054366:Agouti Signaling Protein; D054369:Agouti-Related Protein; C515199:Agrp protein, mouse; D004041:Dietary Fats; D036341:Intercellular Signaling Peptides and Proteins; D007473:Ion Channels; D024101:Mitochondrial Proteins; D009478:Neuropeptide Y; D018722:Nicotinic Agonists; D011943:Receptors, Adrenergic, beta; C000604392:UCP3 protein, human; C000604393:Ucp3 protein, mouse; D000071247:Uncoupling Protein 3; D009538:Nicotine