Strategies for preventing immunologic rejection of transplanted human embryonic stem cells.
Human embryonic stem alls (hESC) have an unlimited capacity of proliferation and self-renewal resulting in a promise for future applications in regenerative medicine. One major problem derived from their use in cellular therapy protocols is the immunological rejection due to HLA incompatibility. Currently, there are four strategies to prevent allograft rejection of hESC; the development of a ''universal hESC line'' with lack of HLA class 1 expression; the creation of nuclear transfer hESC line; the development of hESC line banks; and the generation of haemopoietic chimerism.
Cabrera
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Stem Cell Bank of Andalucia (Spanish Central Node), Hospital Universitario Virgen de las Nieves, Granada, Spain. carmenm.cabrera.sspa@juntadeandalucia.es
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D053595:Embryonic Stem Cells / Q000378:metabolism; D015870:Gene Expression; D006084:Graft Rejection / Q000517:prevention & control*; D006680:HLA Antigens / Q000096:biosynthesis; D006801:Humans; D053652:Nuclear Transfer Techniques; D044968:Regenerative Medicine / Q000379:methods; D033581:Stem Cell Transplantation; D018183:Transplantation Chimera / Q000378:metabolism; D014184:Transplantation, Homologous
D006680:HLA Antigens