Cytotoxic hypothemycin analogues from Hypomyces subiculosus.
Three new hypothemycin analogues were isolated from the fungal strains Hypomyces subiculosus DSM 11931 and DSM 11932. The structures of these compounds were elucidated by spectroscopic methods, chemical conversion, and X-ray crystallographic analysis. One of the analogues, 4-O-demethylhypothemycin, exhibited potent and selective cytotoxic activity against cell lines with a BRAF mutation.
Wee
Janice L
JL
Kosan Biosciences, Inc., Hayward, California 94545, USA. lau@kosan.com
Sundermann
Kurt
K
Licari
Peter
P
Galazzo
Jorge
J
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009154:Mutation; D015025:Zearalenone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; C120440:hypothemycin; D015025:Zearalenone