A novel isoflavonoid from Millettia puguensis.
From the roots of Millettia puguensis (Leguminosae), a novel isoflavonoid (5), 2'-methoxy-4',5'-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3',4'-methylenedioxyisoflavone (3) and 7,2'-dimethoxy-4',5'-methylenedioxyisoflavone (4) were isolated and identified by 1H-, 13C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC50 = 32 microM against Leishmania infantum), and a moderate cytotoxicity for compound 2 (IC50 = 43 microM on MRC-5 cells).
Kapingu
Modest C
MC
Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania. mkapingu@muchs.ac.tz
Mbwambo
Zakaria H
ZH
Moshi
Mainen J
MJ
Magadula
Joseph J
JJ
Cos
Paul
P
Berghe
Dirk Vanden
DV
Maes
Louis
L
Theunis
Mart
M
Apers
Sandra
S
Pieters
Luc
L
Vlietinck
Arnold
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018314:Leishmania infantum / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy; D016778:Malaria, Falciparum / Q000188:drug therapy; D033641:Millettia; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D010963:Plasmodium falciparum / Q000187:drug effects; D014345:Trypanosoma / Q000187:drug effects; D014352:Trypanosomiasis / Q000188:drug therapy
D000981:Antiprotozoal Agents; D007529:Isoflavones; D010936:Plant Extracts