The missing link between cardiovascular rhythm control and myocardial cell modeling.
Cardiac arrhythmia is currently investigated from two different points of view. One considers ECG bio-signal analysis and investigates heart rate variability, baroreflex control, heart rate turbulence, alternans phenomena, etc. The other involves building computer models of the heart based on ion channels, bio-domain models and forward calculations to finally reach ECG and body surface potential maps. Both approaches aim to support the cardiologist in better understanding of arrhythmia, improving diagnosis and reliable risk stratification, and optimizing therapy. This article summarizes recent results and aims to trigger new research to bridge the different views.
Dössel
Olaf
O
Institute of Biomedical Engineering, Universität Karlsruhe (TH), Karlsruhe, Germany. olaf.doessel@ibt.uni-karlsruhe.de
Reumann
Matthias
M
Seemann
Gunnar
G
Weiss
Daniel
D
D001683:Biological Clocks; D003198:Computer Simulation; D005246:Feedback; D006321:Heart / Q000503:physiopathology*; D006329:Heart Conduction System / Q000503:physiopathology*; D006339:Heart Rate; D006706:Homeostasis; D006801:Humans; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac; D010507:Periodicity