title: Influence of glycemic control on pulmonary function and heart rate in response to exercise in subjects with type 2 diabetes mellitus.
abstract: Conflicting results exist regarding the impact of glycemic control on peak oxygen uptake (VO2peak) in subjects with type 2 diabetes mellitus. The influence of glycemic control on submaximal oxygen uptake (VO2) in these subjects is unknown. The aim of this study was to evaluate the impact of fasting blood glucose (FBG) (short-term glycemic control) and glycated hemoglobin (HbA1c) (long-term glycemic control) on submaximal VO2 and VO2peak during exercise in subjects with type 2 diabetes mellitus without cardiovascular disease. FBG and HbA1c levels and exercise tolerance in 30 sedentary men with type 2 diabetes mellitus treated with oral hypoglycemic agents and/or diet were evaluated. VO2, carbon dioxide production (VCO2), heart rate, pulmonary ventilation (VE), and the respiratory exchange ratio (RER) were measured throughout the exercise protocol. Subjects were separated into 2 groups of the same age, weight, and body mass index according to median FBG and HbA1c levels (6.5 mmol/L and 6.1%, respectively). Per protocol design, there was a significant difference in FBG and HbA1c levels (P < .001), but not for age, weight, or body mass index. There was no significant difference in peak exercise parameters between the 2 groups according to median FBG or median HbA1c levels. However, the subjects with elevated HbA1c level had lower submaximal V e throughout the exercise protocol (P < .03), and the subjects with elevated FBG concentration had a blunted heart rate pattern during submaximal exercise (P < .03). Although relatively small abnormalities in the control of glycemia do not affect VO2peak in subjects with type 2 diabetes mellitus without cardiovascular disease, they may influence pulmonary function and the chronotropic response during submaximal exercise in these subjects.
authors.affiliation: Centre de Recherche, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Université Laval, Ste-Foy, Québec, Canada G1V 4G5.
authors.forename: Patrice
authors.initials: P
authors.lastname: Brassard
authors.forename: Annie
authors.initials: A
authors.lastname: Ferland
authors.forename: Peter
authors.initials: P
authors.lastname: Bogaty
authors.forename: Marc
authors.initials: M
authors.lastname: Desmeules
authors.forename: Jean
authors.initials: J
authors.lastname: Jobin
authors.forename: Paul
authors.initials: P
authors.lastname: Poirier
mesh_terms: D001786:Blood Glucose / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance / Q000502:physiology; D006442:Glycated Hemoglobin / Q000378:metabolism; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D012119:Respiration
chemical_list: D001786:Blood Glucose; D002245:Carbon Dioxide; D006442:Glycated Hemoglobin