Colonoscopic screening for colorectal cancer improves quality of life measures: a population-based screening study.
BACKGROUND
Screening asymptomatic individuals for neoplasia can have adverse consequences on quality of life. Colon cancer screening is widespread but the quality of life (QOL) consequences are unknown. This study determined the impact of screening colonoscopy on QOL measures in asymptomatic average-risk participants.


METHODS
Asymptomatic male and female participants aged 55-74 years were randomly selected from the Australian Electoral Roll or six primary care physicians' databases. Participants completed the Short-Form (SF-36) Quality of Life Assessment at baseline and at a mean of 39 days after colonoscopy. Outcome measures were (i) significant changes in raw scores in any of the eight SF-36 domains assessed following colonoscopic screening and (ii) improvements or declines in previously validated categories, representing clinically significant changes, within any of the eight SF-36 domains.


RESULTS
Baseline QOL measures were similar to those of a matched general population sample. Role Limitations due to Emotions, Mental Health and Vitality raw scores significantly improved following colonoscopy (P < 0.05, 2-tailed t-test). Health ratings according to Category were similar (same clinical status) in the majority of participants. However, 30% participants recorded clinically significant improvement in the Mental Health and Vitality domains (P < 0.05, Wilcoxon Signed-Ranks test). This improvement was not offset by declines in other domains or in other participants. Improvement in QOL was not related to colonoscopy results.


CONCLUSIONS
Average-risk persons benefit significantly from colon cancer screening with colonoscopy, improving in Mental Health and Vitality domains of Quality of Life. This improvement is not offset by declines in other domains.
Taupin
Doug
D
Gastroenterology and Hepatology Unit and Centre for Advances in Epidemiology and Information Technology, The Canberra Hospital, Yamba Drive, Garran, Australian Capital Territory, Australia. Doug.Taupin@act.gov.au
Chambers
Sharon L
SL
Corbett
Mike
M
Shadbolt
Bruce
B
D018256:Adenomatous Polyps / Q000175:diagnosis / Q000523:psychology; D000368:Aged; D001007:Anxiety; D020958:Australian Capital Territory; D003111:Colonic Polyps / Q000175:diagnosis / Q000523:psychology; D003113:Colonoscopy / Q000009:adverse effects / Q000523:psychology / Q000706:statistics & numerical data*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000517:prevention & control / Q000523:psychology; D003430:Cross-Sectional Studies; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000523:psychology / Q000706:statistics & numerical data*; D008603:Mental Health; D008875:Middle Aged; D010147:Pain Measurement; D011320:Primary Health Care; D011788:Quality of Life / Q000523:psychology*; D016896:Treatment Outcome