title: Which factors are important predictors of non-recovery from major depression? A 2-year prospective observational study.
abstract: Our aim was to study factors associated with long-term non-recovery from major depression. A total of 109 patients with major depression were followed prospectively for 2 years. A diagnosis of major depression based on SCID interviews at follow-up indicated non-recovery. The effect of several established risk factors was assessed. A third (30%) of the patients did not recover. Severity of initial depression were associated with poor outcome according to univariate analysis. Nevertheless, personality disorder and rural area of residence were associated with non-recovery in final multivariate analysis. Major depression in patients with personality disorder should be treated as effectively as possible. Moreover, service planning in rural areas needs attention.
authors.affiliation: Department of Psychiatry, Kuopio University Hospital, University of Kuopio, Finland. heimo.viinamaki@kuh.fi
authors.forename: Heimo
authors.initials: H
authors.lastname: Viinamäki
authors.forename: Kaisa
authors.initials: K
authors.lastname: Haatainen
authors.forename: Kirsi
authors.initials: K
authors.lastname: Honkalampi
authors.forename: Antti
authors.initials: A
authors.lastname: Tanskanen
authors.forename: Heli
authors.initials: H
authors.lastname: Koivumaa-Honkanen
authors.forename: Risto
authors.initials: R
authors.lastname: Antikainen
authors.forename: Minna
authors.initials: M
authors.lastname: Valkonen-Korhonen
authors.forename: Jukka
authors.initials: J
authors.lastname: Hintikka
mesh_terms: D000328:Adult; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010554:Personality Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012424:Rural Population; D012959:Socioeconomic Factors; D013223:Statistics as Topic; D017211:Treatment Failure