title: Goitrous congenital hypothyroidism in a twin pregnancy causing respiratory obstruction at birth: implications for management.
abstract: We report a twin pregnancy complicated by fetal goitrous hypothyroidism secondary to dyshormonogenesis caused by thyroglobulin deficiency. Antenatal treatment with intra-amniotic thyroxine was considered but not performed, given the late gestational age at diagnosis and the multiple nature of the pregnancy. Both twins developed airway obstruction at delivery, requiring intubation and ventilation. We review the literature and describe the practical issues relating to the antenatal assessment and perinatal management of fetal goitre.
authors.affiliation: Yorkhill Division, Queen Mother's Hospital, Glasgow, UK. pinkdoc@doctors.net.uk
authors.forename: Ben Christopher
authors.initials: BC
authors.lastname: Reynolds
authors.forename: Judith Helen
authors.initials: JH
authors.lastname: Simpson
authors.forename: Lena
authors.initials: L
authors.lastname: Macara
authors.forename: Andrew James Bruce
authors.initials: AJ
authors.lastname: Watt
authors.forename: Haytham
authors.initials: H
authors.lastname: Kubba
authors.forename: Malcolm David Cairns
authors.initials: MD
authors.lastname: Donaldson
authors.forename: Joachim
authors.initials: J
authors.lastname: Pohlen
mesh_terms: D000402:Airway Obstruction / Q000209:etiology / Q000628:therapy; D003409:Congenital Hypothyroidism / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D036861:Delivery, Obstetric; D004200:Diseases in Twins; D005260:Female; D006042:Goiter / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013954:Thyroglobulin / Q000172:deficiency
chemical_list: D013954:Thyroglobulin