Late response to radiochemotherapy in pediatric glioblastoma: report on two patients treated according to HIT-GBM protocols.
High-grade gliomas in children are rare and the best treatment is undetermined. The German language group study HIT-GBM compares various induction protocols for subsequent patient cohorts. Currently, cisplatinum, etoposide, ifosfamide, and vincristine are given simultaneously with extended-field radiotherapy. Imaging is done 3 weeks after to define treatment response, followed by 6-weekly controls during consolidation with lomustine, vincristine, and prednisone. The authors report on 2 patients with incompletely resected glioblastoma multiforme in which response was lacking 3 weeks after radiochemotherapy but became evident 12 weeks later. This suggests that later time points are required to assess induction protocol response.
Classen
C F
CF
Children's Hospital, Wedau Kliniken, Klinikum Duisburg, Duisburg, Germany. cfclassen@gmx.de
Warmuth-Metz
M
M
Papke
K
K
Trotter
A
A
Wolff
J E A
JE
Wagner
S
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D020295:Brain Stem Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003399:Craniotomy; D018450:Disease Progression; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D015173:Supratentorial Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D005047:Etoposide; D002945:Cisplatin; D007069:Ifosfamide