Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones.
The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.
Ullrich
John W
JW
Chemical and Screening Sciences Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. ullricj@wyeth.com
Unwalla
Rayomand J
RJ
Singhaus
Robert R
RR
Harris
Heather A
HA
Mewshaw
Richard E
RE
D018360:Crystallography, X-Ray; D047629:Estrogen Receptor beta / Q000819:agonists* / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D008024:Ligands; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry*
D047629:Estrogen Receptor beta; D007211:Indoles; D008024:Ligands; D010797:Phthalimides