Cognate interaction between endothelial cells and T cells.
Endothelial cells lining the blood vessels form a barrier between circulating immune cells and parenchymal tissue. While the molecular mechanisms involved in antigen-independent recruitment of leukocytes into infected tissue have been extensively studied, the mechanisms involving antigen-specific recruitment of T cells into tissue have remained largely elusive. Here I shall review the experimental evidence that endothelial cells function as antigen-presenting cells and in this function contribute first to regulation of immune responses and second, to antigen-specific recruitment of T cells.
Knolle
Percy A
PA
Institute for Molecular Medicine and Experimental Immunology, Friedrich-Wilhelms-Universität Bonn, Germany. Percy.Knolle@ukb.uni-bonn.de
D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D042783:Endothelial Cells / Q000276:immunology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens