title: Comparison of romifidine and medetomidine pre-medication in propofol-isoflurane anaesthetised dogs.
abstract: The objective of this paper was to evaluate romifidine as a pre-medicant in dogs prior to propofol-isoflurane anaesthesia, and to compare it with medetomidine. For this, eight healthy dogs were anaesthetised. Each dog received three pre-anaesthetic protocols: R40 (romifidine, 40 microg/kg, IV), R80 (romifidine, 80 microg/kg, IV) or MED (medetomidine, 10 microg/kg, IV). Induction of anaesthesia was delivered with propofol and maintained with isoflurane. The following variables were studied before sedative administration and 10 min after sedative administration: heart rate (HR), mean arterial pressure (MAP), systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) and respiratory rate (RR). During maintenance, the following variables were recorded at 5-min intervals: HR, MAP, SAD, DAP, arterial oxygen saturation (SpO(2)), end-tidal CO(2)(EtCO(2)), end-tidal concentration of isoflurane (EtISO) required for maintenance of anaesthesia and tidal volume (TV). Time to extubation, time to sternal recumbency and time to standing were also registered. HR and RR experimented a significantly decreased during sedation in all protocols respect to baseline values. Mean HR, MAP, SAP, DAP, SpO(2), EtCO(2), and TV during anaesthesia were similar for the three protocols. End tidal of isoflurane concentration was statistically similar for all protocols. Recovery time for R40 was significantly shorter than in R80 and MED. The studied combination of romifidine, propofol and isoflurane appears to be an effective drug combination for inducing and maintaining general anaesthesia in healthy dogs.
authors.affiliation: Department of Animal Medicine and Surgery, University of Córdoba, Campus Universitario de Rabanales, Cordoba, Spain. pv1govir@uco.es
authors.forename: R J
authors.initials: RJ
authors.lastname: Gómez-Villamandos
authors.forename: J M
authors.initials: JM
authors.lastname: Domínguez
authors.forename: J I
authors.initials: JI
authors.lastname: Redondo
authors.forename: E M
authors.initials: EM
authors.lastname: Martín
authors.forename: M M
authors.initials: MM
authors.lastname: Granados
authors.forename: I
authors.initials: I
authors.lastname: Ruiz
authors.forename: J M
authors.initials: JM
authors.lastname: Santisteban
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D020926:Medetomidine / Q000494:pharmacology*; D010101:Oxygen Consumption; D015742:Propofol / Q000494:pharmacology; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
chemical_list: D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; C076257:romifidine; D007530:Isoflurane; D020926:Medetomidine; D015742:Propofol