title: Expression of MxA protein in blood lymphocytes of children receiving anticancer chemotherapy.
abstract: The aim of the study was to evaluate whether IFN-alpha/beta-inducible MxA protein expression in children receiving anticancer treatment can be used as an indicator for virus infections during the febrile episodes. Twenty-six children with mainly hematological malignancies entered the study. Children with laboratory-confirmed virus infections had clearly elevated MxA protein levels compared to their counterparts with bacterial or unknown etiology. MxA protein expression increased moderately following the administration of cytostatic agents, even though these children had no clinical signs of infection.
authors.affiliation: Turku Immunology Centre and Departments of Pediatrics and Virology, University of Turku, Turku, Finland. Minna.Koskenvuo@utu.fi
authors.forename: Minna M
authors.initials: MM
authors.lastname: Koskenvuo
authors.forename: Markus
authors.initials: M
authors.lastname: Halminen
authors.forename: Miia
authors.initials: M
authors.lastname: Blomqvist
authors.forename: Raija
authors.initials: R
authors.lastname: Vainionpää
authors.forename: Jorma
authors.initials: J
authors.lastname: Ilonen
authors.forename: Ilkka
authors.initials: I
authors.lastname: Julkunen
authors.forename: Toivo T
authors.initials: TT
authors.lastname: Salmi
authors.forename: Mika J
authors.initials: MJ
authors.lastname: Mäkelä
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004198:Disease Susceptibility; D005260:Female; D005334:Fever / Q000097:blood / Q000209:etiology; D019204:GTP-Binding Proteins / Q000097:blood*; D019337:Hematologic Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D016898:Interferon-alpha / Q000502:physiology; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D064547:Myxovirus Resistance Proteins; D009369:Neoplasms / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D011237:Predictive Value of Tests; D014777:Virus Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D016898:Interferon-alpha; C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; D019204:GTP-Binding Proteins