title: Pleomorphic presentation of cutaneous lesions associated with the proteasome inhibitor bortezomib in patients with multiple myeloma.
abstract: The clinical course and histologic findings of cutaneous adverse reactions associated with bortezomib treatment are presented in this study. Bortezomib (Velcade) is a proteasome inhibitor, which is used as a novel anticancer drug in the treatment of multiple myeloma. We have conducted an observational analysis of 47 patients with myeloma who were treated with bortezomib in 3 prospective clinical trials. Cutaneous adverse reactions were observed in 6 patients (13%). Five patients presented with sharply demarcated erythematous plaques or nodules on the trunk and one patient had generalized morbilliform erythema with ulcerations and fever. The time between the first bortezomib dose and occurrence of the cutaneous eruptions was at least 30 days. The cutaneous eruptions usually resolve within a few days. One patient withdrew from further treatment because of severe cutaneous toxicity. The histologic findings ranged from perivascular dermatitis to interstitial and interface dermatitis corresponding with clinically more extensive lesions.
authors.affiliation: Department of Hematology, Erasmus MC, Rotterdam, The Netherlands. k.wu@erasmusmc.nl
authors.forename: Ka Lung
authors.initials: KL
authors.lastname: Wu
authors.forename: Freerk
authors.initials: F
authors.lastname: Heule
authors.forename: King
authors.initials: K
authors.lastname: Lam
authors.forename: Pieter
authors.initials: P
authors.lastname: Sonneveld
mesh_terms: D000328:Adult; D000368:Aged; D001897:Boronic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D000069286:Bortezomib; D003875:Drug Eruptions / Q000188:drug therapy / Q000473:pathology*; D004359:Drug Therapy, Combination; D004890:Erythema / Q000139:chemically induced / Q000473:pathology; D005334:Fever / Q000139:chemically induced; D005938:Glucocorticoids / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use; D011480:Protease Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011719:Pyrazines / Q000009:adverse effects* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012883:Skin Ulcer / Q000139:chemically induced
chemical_list: D001897:Boronic Acids; D005938:Glucocorticoids; D006634:Histamine H1 Antagonists; D011480:Protease Inhibitors; D011719:Pyrazines; D000069286:Bortezomib; D011241:Prednisone