title: Tissue Doppler assessment of longitudinal right and left ventricular strain and strain rate in pulmonary artery hypertension.
abstract: Tissue Doppler imaging (TDI) in 38 adult patients with pulmonary artery hypertension of varied etiology and normal left ventricular systolic function by two-dimensional transthoracic echocardiography showed significantly reduced peak systolic strain (SS) in all three segments of left ventricular free wall and ventricular septum and two of three segments of right ventricular free wall when compared to 29 adults with no clinical or echocardiographic evidence of heart disease and normal left and right ventricular systolic function. A similar reduction in peak diastolic strain (DS) was also noted in all three segments of left ventricular free wall and ventricular septum and one of three segments of right ventricular free wall. This reduction in strain indices in patients with pulmonary hypertension was noted irrespective of whether right ventricular systolic function was normal or reduced as assessed by two-dimensional transthoracic echocardiography. SS and DS rates also showed reductions in patients with pulmonary artery hypertension. Our study shows the potential value of TDI indices in identifying reduced regional left ventricular systolic and diastolic longitudinal function in patients with pulmonary artery hypertension and normal left ventricular systolic function by two-dimensional transthoracic echocardiography. This reduction in left ventricular function was noted in patients with both normal and reduced right ventricular systolic functions by two-dimensional echocardiography.
authors.affiliation: Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, Alabama, 35249, USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Rajdev
authors.forename: Navin C
authors.initials: NC
authors.lastname: Nanda
authors.forename: Vinod
authors.initials: V
authors.lastname: Patel
authors.forename: Anurag
authors.initials: A
authors.lastname: Singh
authors.forename: Farhat
authors.initials: F
authors.lastname: Mehmood
authors.forename: Srinivas
authors.initials: S
authors.lastname: Vengala
authors.forename: Ligang
authors.initials: L
authors.lastname: Fang
authors.forename: Velayudhan
authors.initials: V
authors.lastname: Dasan
authors.forename: Raymond L
authors.initials: RL
authors.lastname: Benza
authors.forename: Robert C
authors.initials: RC
authors.lastname: Bourge
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011651:Pulmonary Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure; D012107:Research Design; D012720:Severity of Illness Index; D013318:Stroke Volume; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000503:physiopathology