Kainate receptor-interacting proteins and membrane trafficking.
Kainate receptors are composed of several subunits and splice variants, but the relevance of this diversity is still not well understood. The subunits and splice variants show great divergence in their C-terminal cytoplasmic tail region, which has been identified as a region of interaction with a number of protein partners. Differential trafficking of kainate receptors to neuronal compartments is likely to rely on interactions with distinct subsets of protein partners. This review summarizes our knowledge of the regulation of trafficking of kainate receptors and focuses on the identification and characterization of functions of interacting partners.
Coussen
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F
CNRS UMR 5091, Laboratoire Physiologie Cellulaire de la Synapse, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux Cedex, France.
Mulle
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C
D000368:Aged; D017398:Alternative Splicing; D002462:Cell Membrane / Q000502:physiology*; D014644:Genetic Variation; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D018092:Kainic Acid Receptors / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000378:metabolism
D008565:Membrane Proteins; D021122:Protein Subunits; D018092:Kainic Acid Receptors; D011994:Recombinant Proteins