Elevation of serum high-mobility group box 1 protein during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilisation.
High mobility group box 1 (HMGB1) is a non-histone protein involved in maintaining the architecture of chromatin. HMGB1 also acts extracellularly as a cytokine, in processes such as inflammation, cell migration and stem cell recruitment. The involvement of HMGB1 in granulocyte colony-stimulating factor (G-CSF)-induced mobilisation of haematopoietic stem cells was investigated in 21 healthy donors. G-CSF treatment significantly elevated serum HMGB1 levels, which increased from 1.16 +/- 0.86 ng/ml, before treatment, to 31.1 +/- 5.99 ng/ml, after treatment. These findings suggest HMGB1 may play a role during the mobilisation of stem cells from the bone marrow into the systemic circulation.
Tagami
Kozo
K
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan.
Yujiri
Toshiaki
T
Tanimura
Atsuko
A
Mitani
Noriyuki
N
Nakamura
Yukinori
Y
Ariyoshi
Koichi
K
Ando
Toshihiko
T
Fujii
Yasuhiko
Y
Tanizawa
Yukio
Y
D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000097:blood; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D024243:HMGB1 Protein / Q000097:blood* / Q000187:drug effects; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D011994:Recombinant Proteins
D018952:Antigens, CD34; D024243:HMGB1 Protein; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor