Antinociceptive activity of the pyranocoumarin seselin in mice.
Seselin an angular pyranocoumarin at dose of 0.5, 4.5 or 40.5 mg/kg inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4%, respectively. Using the same doses, seselin elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively. Besides, a significant reduction of licking time was observed during the first phase (neurogenic) at the highest doses of seselin, by 34.4% and 66.9%, respectively. On the contrary, in the hot plate test no effect was observed after seselin treatment. In conclusion, seselin was able to inhibit inflammatory hyperalgesia, suggesting that this natural product possesses both important peripheral anti-inflammatory and antinociceptive properties.
Lima
Vilma
V
Health Sciences Center, Course of Pharmaceutical Sciences, University of Fortaleza (UNIFOR), Fortaleza, Brazil. villima@yahoo.com.br
Silva
Caio B
CB
Mafezoli
Jair
J
Bezerra
Mirna M
MM
Moraes
M Odorico
MO
Mourão
Guilherme S M M
GS
Silva
J Nunes
JN
Oliveira
M Conceição F
MC
D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D039681:Pyranocoumarins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011714:Pyrans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027821:Rutaceae
D000700:Analgesics; D003374:Coumarins; D010936:Plant Extracts; D039681:Pyranocoumarins; D011714:Pyrans; D005557:Formaldehyde; C516746:seselin; D019342:Acetic Acid