title: Quantification of hepatic parenchymal blood flow by contrast ultrasonography with flash-replenishment imaging.
abstract: Flash-replenishment (FR) utilizes destruction of microbubbles in the scan volume by high-power ultrasound and enables to observe reperfusion at a low acoustic power. In this paper, we introduced theoretic equation between probability density function (PDF) of the transit time in the scan volume and time intensity curve (TIC) measured by FR method. From the equations, it was explained that the mean transit time (MTT) through the scan volume was calculated from the plateau level and tangent of the initial slope. Animal experiments were also performed to measure TIC in the parenchymal region of the liver using FR method. From the result of the TIC, the variant of the PDF for the transit time was found to be small and the average MTT was 11.1 s. Hepatic blood flow by an ultrasonic transit time flowmeter was also measured in the same experiment, and adequate correlation was obtained from between the two methods. The results suggested that the FR method, which is a noninvasive measurement, can predict the blood flow of the liver.
authors.affiliation: The Fourth Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Metoki
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
authors.forename: Naohisa
authors.initials: N
authors.lastname: Kamiyama
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Hiroko
authors.initials: H
authors.lastname: Iijima
authors.forename: Hui-Xiong
authors.initials: HX
authors.lastname: Xu
authors.forename: Takaya
authors.initials: T
authors.lastname: Aoki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Miyata
authors.forename: Kei
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Kosei
authors.initials: K
authors.lastname: Kudo
authors.forename: Masafumi
authors.initials: M
authors.lastname: Shimizu
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003287:Contrast Media; D007089:Image Enhancement / Q000379:methods; D008102:Liver Circulation; D045423:Microbubbles; D010743:Phospholipids; D011817:Rabbits; D012212:Rheology; D013459:Sulfur Hexafluoride; D014465:Ultrasonics; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride