Effect of mitomycin C on the size of antrostomy after endoscopic sinus surgery.
OBJECTIVE
Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. We aimed to evaluate the effect of MMC on the size of antrostomy and the mucociliary clearance rate.


METHODS
We selected 20 patients with chronic sinusitis on both sides. After middle meatal antrostomy, we selected one side, and a piece of Merocel soaked with 1.5 mL of MMC (0.4 mg/mL) was applied for 5 minutes. On the other side, normal saline solution was applied for a control. The size of the antrostomy was measured serially after surgery with a ruler. Mucociliary clearance was assessed by the saccharin test.


RESULTS
The effect of MMC in maintaining the size of the antrostomy was only significant during the first month. The relative size (the ratio of the remaining antrostomy area compared to the area in the immediate postoperative period) in the first month was significantly greater on the MMC-treated side than on the control side. The results of the saccharin test were not different between the two sides.


CONCLUSIONS
Topical MMC application may have a short-term effect in maintaining the patency of the antrostomy site. However, it does not seem to improve the relative size over an extended period of time.
Kim
Seon-Tae
ST
Department of Otolaryngology, Gil Medical Center, Gachon Medical School, Incheon City, South Korea.
Gang
Il-Gyu
IG
Cha
Heung-Eog
HE
Ha
Jong-Su
JS
Chung
Yoo-Sam
YS
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002908:Chronic Disease; D002921:Cicatrix / Q000517:prevention & control; D003251:Constriction, Pathologic / Q000517:prevention & control; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D015523:Maxillary Sinusitis / Q000601:surgery*; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin