Alpha-amylase inhibitors from Brazilian seaweeds and their hypoglycemic potential.
The acetone crude extract of Lobophora variegata did not show any alpha-amylase inhibition activity. On the contrary, acetone crude extract of both Spatoglossum schroederi and Caulerpa racemosa inhibited the enzyme activity, with an ED(50) of 0.58 and 0.09 mg/ml.
Teixeira
Valéria L
VL
Departamento de Biologia Marinha, Instituto de Biologia, Universidade Federal Fluminense, PO Box 100.644, Niterói, RJ, 24001-970, Brazil. gbmvalt@bm.uff.br
Rocha
Fabíola D
FD
Houghton
Peter J
PJ
Kaplan
Maria Auxiliadora C
MA
Pereira
Renato C
RC
D001938:Brazil; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012624:Seaweed; D000516:alpha-Amylases / Q000009:adverse effects*
D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000516:alpha-Amylases