title: [Intratympanic dexamethasone medication for sudden sensorineural hearing loss: clinical evaluation].
abstract: OBJECTIVE
  To investigate clinical efficacy of intratympanic dexamethasone injection for sudden sensorineural hearing loss.
  
  
  METHODS
  Subjects received an course of at least 7-day dexamethasone [5 g/(L x d)] intratympanic injection. Pure-tone averages (PTA) calculated using air conduction thresholds at 4 -frequencies (500, 1000, 2000, 4000 Hz) at pre-injection and post-injection were compared. The change in PTA greater than 10 dB HL was considered to be effective.
  
  
  RESULTS
  PTA at pre-injection and post-injection were (65.65 +/- 24.73) dB HL and (50.25 +/- 25.59)dB HL respectively in 21 patients with sudden sensorineural hearing loss. There was significant improvement in PTA (P < 0.01). Improvement in hearing was found in 47.6% patients. Promising results of intratympanic dexamethasone medication were found in cases with shorter duration or/and without vertigo. No unexpected adverse events such as otitis media or perforated tympanic membrane or worsening in hearing occurred during the injection or follow-up period.
  
  
  CONCLUSIONS
  Intratympanic dexamethasone medication can be beneficial in treating patient with sudden sensorineural hearing loss. Duration and vertigo are two important factors for prognosis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, 200092, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Xue
authors.forename: Xiangping
authors.initials: X
authors.lastname: Chen
authors.forename: Rongping
authors.initials: R
authors.lastname: Cao
authors.forename: Guozhen
authors.initials: G
authors.lastname: Meng
authors.forename: Mingliang
authors.initials: M
authors.lastname: Xiang
authors.forename: Qi
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D003907:Dexamethasone