[Effects of fufangdenshen tablets on human atherosclerotic plasma protein using proteomic technique].
OBJECTIVE
To research the effects of fufangdenshen tablets on atherosclerotic plasma protein using proteomic technique and further explore its potential molecular mechanism to cure atherosclerosis.


METHODS
The plasma of normal, atherosclerosis and cured group were collected, and the albumin in plasma was removed. Proteomic protocol involved of 2-DE, image analysis and spectrometry detection was used to detect regulated plasma protein by fufangdenshen tablets.


RESULTS
3 decreased expressed and 6 higher protein in atherosclerotic plasma could be recovered by fufangdenshen tablets. The levels of fibrinogen, Granzyme C and immunoglobulin were decreased by fufangdenshen tablets.


CONCLUSIONS
The levels of fibrinogen, Granzyme C in atherosclerotic plasma could be decreased by fufangdenshen tablets. The effects of fufangdenshen tablets on atherosclerosis included that: inhibition of adhesion of monocyte, inhibition of proliferation and migration of VSMC, and weakening of inflammation.
Ma
Zeng-chun
ZC
Institute of Radiation Medicine, Beijing, China.
Gao
Yue
Y
Tan
Hong-ling
HL
Xiao
Cheng-rong
CR
Wu
Hong-jin
HJ
Wang
Sheng-qi
SQ
D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism*; D053804:Granzymes / Q000097:blood; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008875:Middle Aged; D010946:Plants, Medicinal / Q000737:chemistry; D040901:Proteomics; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013607:Tablets
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007136:Immunoglobulins; D013607:Tablets; D005340:Fibrinogen; D053804:Granzymes