Kojic acid and its manganese and zinc complexes as potential radioprotective agents.
The naturally occurring fungal metabolite kojic acid and its manganese and zinc complexes have been evaluated as potential radioprotectors in mice. Their toxicity and radioprotective activity (survival rate) have been determined and compared with that of WR-2721 (amifostine). The results of in vivo radioprotection showed that these compounds exhibited significant radioprotective effects against lethal dose of gamma-irradiation in mice.
Emami
Saeed
S
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. sd_emami@yahoo.com
Hosseinimehr
Seyed Jalal
SJ
Taghdisi
Seyed Mohammad
SM
Akhlaghpoor
Shahram
S
D004999:Amifostine / Q000494:pharmacology; D000818:Animals; D005720:Gamma Rays; D008345:Manganese / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry
D009942:Organometallic Compounds; D011753:Pyrones; D011837:Radiation-Protective Agents; C518993:bis(kojic acid)manganese(II); C518994:bis(kojic acid)zinc(II); D008345:Manganese; C011890:kojic acid; D015032:Zinc; D004999:Amifostine