Sources of heterogeneities in estimating the prevalence of endometriosis in infertile and previously fertile women.
OBJECTIVE
To identify possible sources of heterogeneity in estimates of the prevalence of endometriosis in previously fertile women and in women with infertility.


METHODS
A pooled analysis of previously published studies reporting prevalence estimates.


METHODS
Academic.


METHODS
None.


METHODS
None.


METHODS
None.


RESULTS
There were tremendous heterogeneities in prevalence estimates for both the fertile and infertile groups. In addition, the prevalence estimates increased with the year of publication, but decreased with sample size. For previously fertile women, the heterogeneity in prevalence estimates was no longer significant after the effects of sample size and year of publication on estimates were taken into account. In the infertile group, however, there was still a sizeable heterogeneity unaccounted for after both sample size and year of publication were taken into account.


CONCLUSIONS
A single prevalence estimate for the entire fertile or infertile group may be too simplistic at best. More precise prevalence estimates, likely to be age-dependent, await carefully designed and executed studies that will also record covariates such as age at surgery and referral patterns.
Guo
Sun-Wei
SW
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, USA. swguo@mcw.edu <swguo@mcw.edu>
Wang
Yuedong
Y
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015982:Bias; D015897:Comorbidity; D003627:Data Interpretation, Statistical; D004715:Endometriosis / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis* / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D018401:Sample Size; D012680:Sensitivity and Specificity