title: Desorption electrospray ionization using an Orbitrap mass spectrometer: Exact mass measurements on drugs and peptides.
abstract: Desorption electrospray ionization (DESI) is implemented on an Orbitrap mass spectrometer. The ion source is described and applications which utilize the high-resolution capabilities of the Orbitrap are emphasized, including the characterization of peptides and active ingredients in pharmaceutical tablets. Measurements are made in less than 1 s at a resolution of 60,000. The implications of the data for the mechanisms of DESI are discussed.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Hu
authors.forename: Nari
authors.initials: N
authors.lastname: Talaty
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Noll
authors.forename: R Graham
authors.initials: RG
authors.lastname: Cooks
mesh_terms: D001920:Bradykinin / Q000737:chemistry; D017336:Loratadine / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation* / Q000379:methods*; D013607:Tablets
chemical_list: D010455:Peptides; D004364:Pharmaceutical Preparations; D013607:Tablets; D017336:Loratadine; D001920:Bradykinin