title: Polymorphisms within inflammatory genes and colorectal cancer.
abstract: BACKGROUND
  Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona (Spain).
  
  
  RESULTS
  There was no statistically significant association between the SNPs investigated and colorectal cancer risk.
  
  
  CONCLUSIONS
  The lack of association may show that the inflammatory genes selected for this study are not involved in the carcinogenic process of colorectum. Alternatively, the negative results may derive from no particular biological effect of the analysed polymorphisms in relation to CRC. Otherwise, the eventual biological effect is so little to go undetected, unless analysing a much larger sample size.
authors.affiliation: Genetics-Department of Biology, University of Pisa, via S, Giuseppe 22, 56126, Pisa, Italy. slandi@biologia.unipi.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
authors.forename: Federica
authors.initials: F
authors.lastname: Gemignani
authors.forename: Fabio
authors.initials: F
authors.lastname: Bottari
authors.forename: Lydie
authors.initials: L
authors.lastname: Gioia-Patricola
authors.forename: Elisabet
authors.initials: E
authors.lastname: Guino
authors.forename: María
authors.initials: M
authors.lastname: Cambray
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Biondo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Capella
authors.forename: Laura
authors.initials: L
authors.lastname: Boldrini
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
authors.forename: Victor
authors.initials: V
authors.lastname: Moreno
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics; D018836:Inflammation Mediators / Q000378:metabolism*; D011110:Polymorphism, Genetic
chemical_list: D018836:Inflammation Mediators