[Studies on active substance of anticancer effect in Polygonum cuspidatum].
OBJECTIVE
To supply the scientific basis of research and development of the medicinal value of Polygonum cuspidatum.


METHODS
One composition was isolated from the roots of Polygonum cuspidatum by cytotoxicity based fractionation and identified by HPLC-MS, UV scanning and IR. The inhibition and morphology of L-02, Hep G2, SHZ-888, MCF-7, MCF-7/ADM cells growth caused by this composition was determined by MTT assay and HE dyeing.


RESULTS
This composition was identified as trans-and cis-resveratrol. It could specifically inhibit proliferation of many cancer cells but not human normal liver cell. We investigated the cytotoxicity of resveratrol to adriamycin-resistant MCF-7 cell in virtro.


CONCLUSIONS
Resveratrol is a new anticancer composition which is less toxicity and higher efficiency in Polygonum cuspidatum.
Feng
Lei
L
The Biopharmaceutical Laboratory, School of Biotechnology, Yangtze University, Wuxi, China. feng2000lei@yahoo.com.cn
Zhang
Lian-fen
LF
Yan
Ting
T
Jin
Jian
J
Tao
Wen-yi
WY
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects; D045468:Fallopia japonica / Q000737:chemistry*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D000077185:Resveratrol; D027343:Rhizome / Q000737:chemistry; D013267:Stilbenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D000077185:Resveratrol