title: Decomposition of a laser-Doppler spectrum for estimation of speed distribution of particles moving in an optically turbid medium: Monte Carlo validation study.
abstract: A method for measurement of distribution of speed of particles moving in an optically turbid medium is presented. The technique is based on decomposition of the laser-Doppler spectrum. The theoretical background is shown together with the results of Monte Carlo simulations, which were performed to validate the proposed method. The laser-Doppler spectra were obtained by Monte Carlo simulations for assumed uniform and Gaussian speed distributions of particles moving in the turbid medium. The Doppler shift probability distributions were calculated by Monte Carlo simulations for several anisotropy factors of the medium, assuming the Hanyey-Greenstein phase function. The results of the spectra decomposition show that the calculated speed distribution of moving particles match well the distribution assumed for Monte Carlo simulations. This result was obtained for the spectra simulated in optical conditions, in which the photon is scattered with the Doppler shift not more than once during its travel between the source and detector. Influence of multiple scattering of the photon is analysed and a perspective of spectrum decomposition under such conditions is considered. Potential applications and limitations of the method are discussed.
authors.affiliation: Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland. adam.liebert@ibib.waw.pl
authors.forename: A
authors.initials: A
authors.lastname: Liebert
authors.forename: N
authors.initials: N
authors.lastname: Zołek
authors.forename: R
authors.initials: R
authors.lastname: Maniewski
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D003198:Computer Simulation; D004912:Erythrocytes / Q000502:physiology*; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009010:Monte Carlo Method; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D010316:Particle Size; D013057:Spectrum Analysis / Q000379:methods