Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene.
Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are co-morbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia.
Heiman
Gary A
GA
Department of Epidemiology of Joseph L. Mailman School of Public Health, Columbia University, New York, New York 10032, USA. gah13@columbia.edu
Ottman
Ruth
R
Saunders-Pullman
Rachel J
RJ
Ozelius
Laurie J
LJ
Risch
Neil J
NJ
Bressman
Susan B
SB
D000328:Adult; D004421:Dystonia / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones / Q000235:genetics*; D009154:Mutation; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D010641:Phenotype
D018832:Molecular Chaperones; C108175:TOR1A protein, human