[Studies on the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines].
OBJECTIVE
To study the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines.


METHODS
The drug concentration by in situ perfusion in rats were determined by HPLC.


RESULTS
The hourly absorption percentages of baicalin in stomach, small intestine and colon were 8.05%, - 0.94% and 2.32%, respectively, and baioalein with 34.53%, 30.61% and 4.89%, respectively. The absorption rate constants of baicalein were 0.090 7, 0.083 7, 0.076 6 and 0.048 3, respectively in duodenum, jejunum, ileum and colon.


CONCLUSIONS
Baicalin is moderately absorbed in stomach and poorly in small intestine and colon; Baicalein is well absorbed in stomach and small intestine but worse in colon, suggesting that the former is more suitable to be administered orally. The extensive absorption segments of bacailein suggests that it can be processed into a sustained-release preparation.
Liu
Tai-ming
TM
West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Jiang
Xue-hua
XH
D000818:Animals; D003106:Colon / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D044950:Flavanones / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005419:Flavonoids / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D031363:Scutellaria / Q000737:chemistry
D044950:Flavanones; D005419:Flavonoids; C038044:baicalin; C006680:baicalein