Inhibition activities of Colchicum luteum baker on lipoxygenase and other enzymes.
In vitro enzymes inhibition activities of the crude methanolic extract and various fractions of Colchicum luteum Baker (Liliaceae) including chloroform, ethyl acetate, n-butanol and aqueous were carried out against actylcholinesterase, butyrylcholinesterase, lipoxygenase and urease enzymes. A significant enzyme inhibition activity (89%) is shown by the crude methanolic extract and its fractions against lipoxygenase, while low to significant activity (32-75%) was evident against butyrylcholinesterase. The crude methanolic extract and its various fractions demonstrated low activity (29-61%) against acetylcholinesterase and no activity against urease.
Ahmad
Bashir
B
Department of Pharmacy, University of Peshawar, NWFP, Pakistan. bashirdr2001@yahoo.com
Khan
Haroon
H
Bashir
Shumaila
S
Nisar
M
M
Hassan
M
M
D000110:Acetylcholinesterase / Q000737:chemistry; D002091:Butyrylcholinesterase / Q000737:chemistry; D003079:Colchicum / Q000378:metabolism*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016166:Free Radical Scavengers; D008084:Lipoxygenase / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D014510:Urease / Q000737:chemistry
D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D008084:Lipoxygenase; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D014510:Urease; D000432:Methanol