title: Successful use of recombinant factor VIIa (NovoSeven) in children with compartment syndrome: two case reports.
abstract: Compartment syndrome (CS) is an uncommon bleeding manifestation in patients with liver failure and end-stage renal disease (ESRD). Although prompt intervention is paramount in preventing the tissue necrosis and the permanent functional deficits that may be associated with untreated CS, the indications for initiating therapies for children with CS are not standardized. In this report, we present 2 children, one with ESRD and the other with liver failure, who have CS related to life-threatening bleeding complications and were treated with recombinant factor VIIa (rFVIIa). In conclusion, treatment decisions for patients with CS should be made on a case-by-case basis. The use of rFVIIa is an effective and safe treatment in children with liver failure and ESRD. Surgical treatment should be preferred in patients with CS. However, in patients who have a coagulation defect, the first priority is to correct the clotting deficiency. The use of rFVIIa is a treatment option in children with CS due to a coagulation defect.
authors.affiliation: Department of Pediatric Hematology, Baskent University Faculty of Medicine, Ankara, Turkey. alioglub@gmail.com
authors.forename: Bulent
authors.initials: B
authors.lastname: Alioglu
authors.forename: Zekai
authors.initials: Z
authors.lastname: Avci
authors.forename: Esra
authors.initials: E
authors.lastname: Baskin
authors.forename: Figen
authors.initials: F
authors.lastname: Ozcay
authors.forename: Ismail Cengiz
authors.initials: IC
authors.lastname: Tuncay
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
mesh_terms: D000005:Abdomen; D000293:Adolescent; D003161:Compartment Syndromes / Q000188:drug therapy* / Q000209:etiology; D005167:Factor VII / Q000627:therapeutic use*; D015942:Factor VIIa; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000150:complications; D017093:Liver Failure / Q000150:complications; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa