Cell death in the nervous system.
Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease trigger neuronal cell death through endogenous suicide pathways. Surprisingly, although the cell death itself may occur relatively late in the course of the degenerative process, the mediators of the underlying cell-death pathways have shown promise as potential therapeutic targets.
Bredesen
Dale E
DE
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA. dbredesen@buckinstitute.org
Rao
Rammohan V
RV
Mehlen
Patrick
P
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy; D016923:Cell Death / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D009420:Nervous System / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*