Evidence for an association of high levels of endogenous Acetyl-Ser-Asp-Lys-Pro, a potent mediator of angiogenesis, with acute myeloid leukemia development.
Evidence from clinical and laboratory studies suggests that angiogenesis is important in the progression of solid tumours and hematologic malignancies. We have shown that the naturally occurring tetrapeptide Acetyl-Ser-Asp-Lys-Pro (AcSDKP) is a potent angiogenic factor normally present at nanomolar concentrations in the blood. A murine leukemia model was used to assess whether there was a correlation between levels of endogenous AcSDKP and the development of disease. Levels of AcSDKP in the plasma and bone marrow (BM) cells from mice bearing an acute myeloid leukemia (AML) were five- to ten-fold greater than those in non-leukemic mice. Furthermore, a strong correlation between the concentration of endogenous AcSDKP and the progression of AML was demonstrated. These results are consistent with the marked increase in BM vascularity observed in leukemic mice. The physiologic relevance of these findings awaits further studies and the contribution of AcSDKP to the pathogenesis of leukemia is under investigation.
Liu
Jian-Miao
JM
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France.
Bignon
Jérôme
J
Ilic
Vesna
V
Briscoe
Cecilia
C
Lallemand
Jean-Yves
JY
Riches
Andrew
A
Wdzieczak-Bakala
Joanna
J
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D006131:Growth Inhibitors / Q000097:blood* / Q000494:pharmacology; D007124:Immunoenzyme Techniques; D007942:Leukemia, Experimental / Q000097:blood* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009389:Neovascularization, Pathologic / Q000473:pathology*; D009842:Oligopeptides / Q000097:blood* / Q000494:pharmacology; D013154:Spleen / Q000166:cytology
D006131:Growth Inhibitors; D009842:Oligopeptides; C058504:goralatide