title: Cerebral infarction in Hunter syndrome.
abstract: Hunter syndrome, or mucopolysaccharidosis type II, is an X-linked recessive disorder resulting from iduronate sulfatase deficiency. Typical manifestations include short stature, mental retardation, hydrocephalus, macroglossia and cardiac valvulopathy. We describe a 21-year-old patient who presented with acute ischemic stroke and evidence of cerebral embolization. The echocardiogram demonstrated thickened mitral and aortic valves as potential sources of emboli. We conclude that ischemic stroke secondary to cardioembolization is a potential complication of Hunter syndrome.
authors.affiliation: Department of Neurology, University of California at San Francisco, San Francisco, California, USA.
authors.forename: John
authors.initials: J
authors.lastname: Neely
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Carpenter
authors.forename: Wesley
authors.initials: W
authors.lastname: Hsu
authors.forename: Lori
authors.initials: L
authors.lastname: Jordan
authors.forename: Lucas
authors.initials: L
authors.lastname: Restrepo
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D002550:Cerebral Veins / Q000002:abnormalities / Q000503:physiopathology; D004452:Echocardiography; D006349:Heart Valve Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006351:Heart Valves / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D020766:Intracranial Embolism / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D019586:Intracranial Hypertension / Q000209:etiology / Q000503:physiopathology; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D016532:Mucopolysaccharidosis II / Q000150:complications* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants