title: Effects of bisphenol A and ethynyl estradiol exposure on enzyme activities, growth and development in the fourth instar larvae of Chironomus riparius (Diptera, Chironomidae).
abstract: This study was conducted to determine the toxic effects of bisphenol A (BPA) and ethynyl estradiol (EE), well-known endocrine disruptors, on Chironomus riparius under controlled laboratory conditions. Mortality, enzyme activities, and growth/development parameters were studied as acute, biochemical, and physiological toxicities, respectively. The results of the present study showed activation of catalase and glutathione-S-transferase after BPA and EE exposure, as well as increased emergence failure after EE exposure. This study on the effects of BPA and EE on C. riparius can be an important addition to the knowledge that has been obtained regarding the toxicology of BPA and EE in aquatic organism, on which limited data are available. The data obtained from this study, however, are not sufficient to establish any correlation or casual relationship between these two compounds and the response of C. riparius. Thus, further research is required to come up with direct experimental demonstrations of the wider relationship between the biochemical effects of BPA and EE on C. riparius and their consequences at higher levels of biological organization.
authors.affiliation: Faculty of Environmental Engineering, College of Urban Science, University of Seoul, 90 Jeonnong-Dong, Dongdaemun-gu, Seoul 130-743, Korea.
authors.forename: Se-Bum
authors.initials: SB
authors.lastname: Lee
authors.forename: Jinhee
authors.initials: J
authors.lastname: Choi
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001559:Benzhydryl Compounds; D002683:Chironomidae / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D052244:Endocrine Disruptors / Q000633:toxicity*; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D004997:Ethinyl Estradiol / Q000633:toxicity*; D005982:Glutathione Transferase / Q000378:metabolism; D007814:Larva / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D010544:Peroxidases / Q000378:metabolism; D010636:Phenols / Q000633:toxicity*; D012744:Sex Ratio; D018675:Toxicity Tests; D000098826:Bisphenol A Compounds
chemical_list: D000110:Acetylcholinesterase; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004968:Estrogens, Non-Steroidal; D004997:Ethinyl Estradiol; D005982:Glutathione Transferase; D010544:Peroxidases; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds