Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease.
Since many nuclear proteins are ectopically localized in the cytoplasm in the vulnerable neurons in Alzheimer disease (AD), we speculated that there is failure of the cytoplasmic-nuclear transport machinery in AD. In support of this notion, we found that importin alpha1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano bodies in vulnerable hippocampal neurons in AD. These data suggest a hindrance in importin-mediated cytoplasmic-nuclear transport in AD.
Lee
Hyoung-gon
HG
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. hyoung-gon.lee@case.edu
Ueda
Masumi
M
Miyamoto
Yoichi
Y
Yoneda
Yoshihiro
Y
Perry
George
G
Smith
Mark A
MA
Zhu
Xiongwei
X
D000199:Actins / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D016874:Neurofibrillary Tangles / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D020774:Pick Disease of the Brain / Q000378:metabolism / Q000473:pathology; D028901:alpha Karyopherins / Q000378:metabolism*
D000199:Actins; D028901:alpha Karyopherins; C087978:karyopherin alpha 2