New findings in transgenic, gene knockout and mutant mice.
Mice with experimentally induced or spontaneous genetic alterations continue to provide new and often unexpected information on the mechanisms of mammalian aging. Papers published during the last year (July 1, 2005 through June 30, 2006) contain many exciting findings, including development and characterization of a new animal model for the study of aging. Highlights of these recent developments will be briefly discussed in this Review.
Bartke
Andrzej
A
Geriatrics Research, Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL 62794-9628, USA. abartke@siumed.edu
D000375:Aging / Q000235:genetics*; D000818:Animals; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D005966:Glucuronidase / Q000235:genetics; D013006:Growth Hormone / Q000235:genetics; D006801:Humans; D000090265:Klotho Proteins; D008569:Memory Disorders / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D008817:Mice, Mutant Strains / Q000235:genetics*; D023421:Models, Animal
D013006:Growth Hormone; D005966:Glucuronidase; D000090265:Klotho Proteins