title: Cortical sulci and bipolar disorder.
abstract: The width of cortical sulci in bipolar patients (n=19) and healthy controls (n=35) was examined using a novel automated technique involving magnetic resonance imaging. All sulci were wider for bipolar patients than for healthy controls. Bipolar-control differences were largest for the superior and intermediate frontal sulci, smallest for the occipital and cingulate sulci, and intermediate in magnitude for the other sulci (intraparietal, inferior frontal, and central sulci). The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci.
authors.affiliation: Department of Psychology, University of Texas at San Antonio, Texas 78249, USA, and Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Orsay Cedex, France. Thomas.Coyle@utsa.edu
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Coyle
authors.forename: Peter
authors.initials: P
authors.lastname: Kochunov
authors.forename: Rupal D
authors.initials: RD
authors.lastname: Patel
authors.forename: Fabiano G
authors.initials: FG
authors.lastname: Nery
authors.forename: Jack L
authors.initials: JL
authors.lastname: Lancaster
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mangin
authors.forename: Denis
authors.initials: D
authors.lastname: Rivière
authors.forename: David R
authors.initials: DR
authors.lastname: Pillow
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Davis
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nicoletti
authors.forename: E
authors.initials: E
authors.lastname: Serap Monkul
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.forename: Jair C
authors.initials: JC
authors.lastname: Soares
mesh_terms: D000328:Adult; D001284:Atrophy; D001714:Bipolar Disorder / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged