title: Oxidation chemistry of adenosine-3', 5'-cyclic monophosphate at pyrolytic graphite eletrode.
abstract: The voltammetric oxidation of adenosine-3',5'-cyclic monophosphate (3',5'-CAMP) has been studied in the pH range 2.13-10.07 using pyrolytic graphite electrode (PGE). Voltammetric, coulometric, spectral studies, and product characterization indicate that the oxidation of 3',5'-CAMP occurs in an EC reaction involving a 6H+, 6e process at pH 7.24. Electrooxidized products were seperated by semipreparative high performance liquid chromatography (HPLC) and were characterized by mp, 1HNMR, FTIR, and GC-mass as allantoin cyclic ribose monophosphate and 3 dimers as the major products. A detailed interpretation of the redox mechanism of 3',5'-CAMP also has been presented to account for the formation of various products.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India. rngcyfcy@iitr.ernet.in
authors.forename: Rajendra N
authors.initials: RN
authors.lastname: Goyal
authors.forename: Anuradha
authors.initials: A
authors.lastname: Tyagi
mesh_terms: D000241:Adenosine / Q000737:chemistry; D000481:Allantoin / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D000242:Cyclic AMP / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D000481:Allantoin; D006108:Graphite; D000242:Cyclic AMP; D000241:Adenosine; D010100:Oxygen