title: Mechanism of N-ethylmaleimide-induced contraction of the frog sartorius muscle.
abstract: We studied parameters of the frog sartorius muscle contraction initiated by ryanodine receptor agonists in the presence of ROS donors. We hypothesized that sodium nitroprusside and hydrogen peroxide inhibit initiation of contractions by N-ethylmaleimide and that this effect of ROS donors on parameters of N-ethylmaleimide-induced contractions is due to a direct effects of sodium nitroprusside and hydrogen peroxide on N-ethylmaleimide, but not to inactivation of ryanodine receptors in the sarcoplasmatic reticulum of frog skeletal muscle.
authors.affiliation: Department of Physiology, Kazan State Medical University.
authors.forename: S N
authors.initials: SN
authors.lastname: Grishin
authors.forename: A V
authors.initials: AV
authors.lastname: Shakirzyanova
authors.forename: A Yu
authors.initials: AY
authors.lastname: Teplov
authors.forename: I M
authors.initials: IM
authors.lastname: Fatkhutdinov
authors.forename: V V
authors.initials: VV
authors.lastname: Valiullin
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D000818:Animals; D005033:Ethylmaleimide / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D011898:Ranidae; D017382:Reactive Oxygen Species / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000187:drug effects
chemical_list: D017382:Reactive Oxygen Species; D019837:Ryanodine Receptor Calcium Release Channel; D005033:Ethylmaleimide