title: Numerical investigation on the flow characteristics and aerodynamic force of the upper airway of patient with obstructive sleep apnea using computational fluid dynamics.
abstract: Developing a mathematical model to predict the abnormal flow characteristics that are produced by obstructive sleep apnea is an important step in learning the pathophysiology of the obstructive sleep apnea (OSA) disease. The present study provides detailed calculations of flow in the pharyngeal airway of a patient with obstructive sleep apnea. To achieve this goal, a computational fluid dynamics model was constructed using raw data from three-dimensional computed tomogram (CT) images of an OSA patient. To reproduce the important transition from laminar to turbulent flow in the pharyngeal airway, the low Reynolds number k-epsilon model was adopted and successfully validated using previous open literature. The results show that the flow in the pharyngeal airway of patients with OSA comprises a turbulent jet formed by area restriction at the velopharynx. This turbulent jet causes higher shear and pressure forces in the vicinity of the velopharynx. From the results, It may be deduced that the most collapsible area in the pharyngeal airway of OSA patients is the velopharynx where minimum intraluminal pressure and maximum aerodynamic force lie.
authors.affiliation: Advanced Power & IT Research Center, Korea Automotive Technology Institute, Chonan, Chungnam 330-912, Republic of Korea.
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Woo-Seung
authors.initials: WS
authors.lastname: Kim
authors.forename: Sang-Jin
authors.initials: SJ
authors.lastname: Sung
mesh_terms: D000328:Adult; D003198:Computer Simulation; D006801:Humans; D008297:Male; D008954:Models, Biological; D010614:Pharynx / Q000503:physiopathology*; D011312:Pressure; D012123:Pulmonary Ventilation; D015656:Respiratory Mechanics; D012212:Rheology / Q000379:methods; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D013314:Stress, Mechanical