title: Prognosis of very large first-trimester hematomas.
abstract: OBJECTIVE
  The aim of this study was to evaluate the outcome of pregnancies complicated by very large hematomas in the first trimester.
  
  
  METHODS
  Between January 2001 and January 2006, 8085 patients between 5 and 14 weeks' gestation underwent routine first-trimester ultrasonographic examinations at our practice. Of these, 30 patients had a "very large" (> 50% of the gestational sac) intrauterine hematoma. These 30 patients were further classified according to pregnancy outcome (normal or adverse), maternal age, vaginal bleeding, crown-rump length, gestational age at diagnosis of the hematoma, and position and location of the hematoma. P < .05 was considered statistically significant.
  
  
  RESULTS
  Six patients were excluded (4 were still pregnant, and 2 were lost to follow-up), leaving 24 patients eligible for analysis, of which 11 (46%) had adverse outcomes and 13 (54%) had normal outcomes. The group with adverse outcomes had a significantly lower gestational age at diagnosis than the second group (7 weeks [range, 5.7-8.4 weeks] versus 8.4 weeks [range, 6.2-14 weeks]; P = .0227), but crown-rump length, vaginal bleeding, and position and location of the hematoma were similar.
  
  
  CONCLUSIONS
  Very large hematomas were associated with adverse outcome in 46% of the pregnancies. Vaginal bleeding was not associated with a poor prognosis. Neither position nor location of the placental hematoma was related to the outcome; however, when the hematoma was diagnosed at an early gestational age, the outcomes were worse.
authors.affiliation: Inner Vision Women's Ultrasound, Nashville, TN 37203-1926 USA. juliana.mbl@gmail.com
authors.forename: Juliana
authors.initials: J
authors.lastname: Leite
authors.forename: Pamela
authors.initials: P
authors.lastname: Ross
authors.forename: A Cristina
authors.initials: AC
authors.lastname: Rossi
authors.forename: Philippe
authors.initials: P
authors.lastname: Jeanty
mesh_terms: D000328:Adult; D005260:Female; D006406:Hematoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011379:Prognosis; D016216:Ultrasonography, Prenatal