title: Intra-anal collagen injection for the treatment of faecal incontinence.
abstract: BACKGROUND
  Intra-anal injectable agents have been used to treat faecal incontinence. The aim of this study was to report the experience of a cohort of patients who underwent intra-anal injection of collagen and to determine which patients benefited from the technique.
  
  
  METHODS
  Data, including age, sex, incontinence score, classification of incontinence, baseline resting pressure and vector volume, were collected prospectively for 73 consecutive patients (59 women) undergoing intra-anal collagen injection. Patients were reviewed after treatment and incontinence scores documented. A proportion of patients also underwent repeat anorectal physiological testing 8 weeks after the procedure.
  
  
  RESULTS
  At a median follow-up of 12 months after the intra-anal injection, 63 per cent of patients had an improved incontinence score and 73 per cent reported an overall improvement in symptoms. Logistic regression showed that older age and idiopathic faecal incontinence were predictors of a successful outcome (P = 0.042 and P = 0.048 respectively).
  
  
  CONCLUSIONS
  Intra-anal collagen injection appears to have a role in the treatment of faecal incontinence. The majority of patients can expect both objective and subjective improvement. The best results are achieved in older patients and in those with idiopathic incontinence.
authors.affiliation: Department of Colorectal Surgery, Leeds General Infirmary, Leeds, UK.
authors.forename: S G
authors.initials: SG
authors.lastname: Stojkovic
authors.forename: M
authors.initials: M
authors.lastname: Lim
authors.forename: D
authors.initials: D
authors.lastname: Burke
authors.forename: P J
authors.initials: PJ
authors.lastname: Finan
authors.forename: P M
authors.initials: PM
authors.lastname: Sagar
mesh_terms: D000285:Administration, Rectal; D000368:Aged; D015331:Cohort Studies; D003094:Collagen / Q000008:administration & dosage*; D005242:Fecal Incontinence / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D003094:Collagen