title: Treating open carious lesions in anxious children with ozone. A prospective controlled clinical study.
abstract: OBJECTIVE
  To determine whether the treatment of dental caries with ozone was possible in apprehensive children and to ascertain whether ozone reverses caries in open single-surface lesions. Further, the influence of ozone on laser fluorescence was investigated.
  
  
  METHODS
  82 lesions in 28 children with at least two open single-surface lesions were assessed. The children were anxious and were judged by the referring dentist as non-treatable. For each test lesion, which was treated with ozone, a control lesion was left without ozone treatment. Hardness and laser fluorescence values were assessed and the changes for hardness and laser fluorescence values in the test lesion were compared with the values in the control lesion after 2, 4, 6, and 8 months.
  
  
  RESULTS
  94 percent of the children were treatable and 93% lost their dental anxiety. The hardness values improved significantly in the ozone-treated test lesions after 4, 6, and 8 months (P< 0.05) compared with baseline while the control lesions had no significant change in hardness at any recall interval. Comparing the differences between test and control teeth over time, the laser fluorescence values improved, however the improvement was not statistically significant (P> 0.05). The use of ozone resulted in an average reduction of 13% of the laser fluorescence values immediately after the ozone treatment.
authors.affiliation: Department of Operative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Switzerland. daehnhardt@zmk.unibe.ch
authors.forename: Jan Eric
authors.initials: JE
authors.lastname: Dähnhardt
authors.forename: Thomas
authors.initials: T
authors.lastname: Jaeggi
authors.forename: Adrian
authors.initials: A
authors.lastname: Lussi
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D016854:Dental Anxiety / Q000517:prevention & control*; D003731:Dental Caries / Q000628:therapy*; D003732:Dental Caries Activity Tests; D005260:Female; D005453:Fluorescence; D006244:Hardness / Q000187:drug effects; D006801:Humans; D008297:Male; D010126:Ozone / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D002327:Cariostatic Agents; D010126:Ozone