Effect of the ABO blood group on the proliferative and clonogenic capacity of umbilical cord stem cells.
Possible effects of the ABO blood group on the proliferative and self-renewal capacity of umbilical cord CD34+ cells were evaluated. A, B and O (all Rh D+) CD34+ cells isolated from three placental blood samples were cultured in four platforms with hematopoietic growth factors on a 3-dimensional biocompatible matrix. Results from this study suggest that proliferation of CD34+ cells with the O phenotype may be greater than that of cells with the A or B phenotypes. Further ex vivo studies are required to confirm this finding and to determine the effect of the number and type of other genetically determined cell surface antigens on the capacity of hematopoietic stem cells to respond to cytokines. In addition, clinical studies aimed at determining if the CD34+ donor blood group affects the time to functional hematological reconstitution are recommended.
Galan
Isabel
I
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Hutzel Women's Hospital, Box #4, 3990 John R., Detroit, MI 48201, USA.
Santolaya-Forgas
Joaquin
J
Leon
Juan De
JD
Uhlmann
Rebecca A
RA
Montenegro
Daniel
D
Hume
Roderick
R
Mari
Giancarlo
G
D000017:ABO Blood-Group System / Q000235:genetics; D018952:Antigens, CD34 / Q000235:genetics; D018929:Cell Culture Techniques; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D008297:Male; D014470:Umbilical Cord / Q000166:cytology*
D000017:ABO Blood-Group System; D018952:Antigens, CD34; D036341:Intercellular Signaling Peptides and Proteins