title: Chronic inhaled corticosteroids do not affect the course of acute severe asthma exacerbations in children.
abstract: Chronic therapy with inhaled corticosteroids (ICS) suppresses airway inflammation and increases airway responsiveness to beta(2)-adrenergic receptor agonists. We hypothesized that the chronic use of ICS would be associated with shorter duration of hospitalization in severely ill children with status asthmaticus. An 8-year retrospective chart review was conducted of all children admitted to the ICU with status asthmaticus. During the study period, 241 children were admitted, and 44% reported the use of chronic ICS. ICS use was associated with increased baseline asthma severity, previous hospitalization for asthma, and public insurance status. However, ICS use had no effect on hospital or ICU length of stay, type, and duration of treatments received, or the rate of recovery determined by a standard severity of illness scoring system. In the subsets of patients including children with persistent asthma and those who received intravenous terbutaline, there was also no improvement in outcomes with the use of chronic ICS showing that the chronic use of ICS did not improve response to beta(2)-adrenergic receptor agonists in severely ill children with status asthmaticus. Although useful as a preventive therapy, the chronic use of ICS does not appear to affect the course of severe acute asthma exacerbations in pediatric patients once hospitalized.
authors.affiliation: Department of Pediatrics, Connecticut Children's Medical Center, Hartford, Connecticut06106, USA. ccarrol@ccmckids.org
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Carroll
authors.forename: Anita
authors.initials: A
authors.lastname: Bhandari
authors.forename: Craig M
authors.initials: CM
authors.lastname: Schramm
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Zucker
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000403:Airway Resistance / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data; D007902:Length of Stay; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013224:Status Asthmaticus / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids