title: Schizo-obsessive and obsessive-compulsive disorder: comparison of clinical characteristics and neurological soft signs.
abstract: The purpose of the study was to examine whether schizophrenia with obsessive-compulsive disorder (OCD) represents a severe form of OCD-spectrum disorders on the basis of neurological soft signs (NSS) and obsessive-compulsive (OC) symptoms. Sixteen patients with OCD-schizophrenia, 25 OCD patients and 23 healthy controls (HC) were studied. Scales for the Assessment of Positive (SAPS) and Negative Symptoms (SANS), Clinical Global Impressions Scale and Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) were used to assess the schizophrenic and OC symptomatology. NSS were evaluated with the Neurological Evaluation Scale (NES). OCD-schizophrenics had significantly higher scores on total NES than HC. The patients with OCD were more likely to have total Y-BOCS and subscale scores of compulsions than patients with OCD-schizophrenia. The rate of symmetry obsessions and cleaning/washing compulsions were significantly higher in patients with OCD compared to OCD-schizophrenics. We have found no correlation of OC symptoms with schizophrenic symptomatology. Our findings may suggest that OCD-schizophrenia is a distinct subtype of schizophrenia, not a more severe form of OCD-spectrum disorder.
authors.affiliation: Department of Psychiatry, Adnan Menderes University Faculty of Medicine, Aydin, 09100, Turkey. lsevincok@adu.edu.tr
authors.forename: Levent
authors.initials: L
authors.lastname: Sevincok
authors.forename: Aybars
authors.initials: A
authors.lastname: Akoglu
authors.forename: Hülya
authors.initials: H
authors.lastname: Arslantas
mesh_terms: D000328:Adult; D000339:Affect; D001921:Brain / Q000503:physiopathology*; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000503:physiopathology*; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires