title: Dietary fat, fiber, vegetable, and micronutrients are associated with overall survival in postmenopausal women diagnosed with breast cancer.
abstract: Relatively few studies have assessed the relationship between dietary intakes and survival after breast cancer diagnosis. We investigated the influence of diet, including dietary fat (percentage energy), fiber, vegetable, and fruit intakes, and micronutrients (folate, carotenoids, and vitamin C) on overall survival in women diagnosed with breast cancer. Subjects were postmenopausal women diagnosed with breast cancer (N = 516) between 1994 and 1995 with a mean survival time of 80 mo (SD: 18). Subjects completed a food frequency questionnaire for the year prior to diagnosis. Cox proportional hazards models were used to measure the relationship between dietary intakes and death due to any cause after breast cancer diagnosis. In the multivariate analysis, we found that the hazard ratio [HR and 95% confidence interval (CI)] of dying in the highest tertile compared to the lowest tertile of total fat, fiber, vegetable, and fruit was 3.12 (95% CI = 1.79-5.44), 0.48 (95% CI = 0.27-0.86), 0.57 (95% CI = 0.35-0.94), and 0.63 (95% CI = 0.38-1.05), respectively (P <or= 0.05 for trend, except for fruit intake). Other nutrients including folate, vitamin C, and carotenoid intakes were also significantly associated with reduced mortality (P <or= 0.05 for trend). These results suggest that in postmenopausal women diagnosed with breast cancer, reduced dietary fat and increased fiber, vegetable, fruit, and other nutrient intakes associated with a plant-based, high-fiber diet improves overall survival after breast cancer diagnosis.
authors.affiliation: Department of Health Science, California State University, CA 92834, USA. amceligot@fullerton.edu
authors.forename: Archana Jaiswal
authors.initials: AJ
authors.lastname: McEligot
authors.forename: Joan
authors.initials: J
authors.lastname: Largent
authors.forename: Argyrios
authors.initials: A
authors.lastname: Ziogas
authors.forename: David
authors.initials: D
authors.lastname: Peel
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
mesh_terms: D015992:Body Mass Index; D001943:Breast Neoplasms / Q000401:mortality*; D015331:Cohort Studies; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D018977:Micronutrients / Q000008:administration & dosage*; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D017698:Postmenopause; D016016:Proportional Hazards Models; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D013997:Time Factors; D014675:Vegetables
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber; D018977:Micronutrients