title: Feasibility of boron neutron capture therapy (BNCT) for malignant pleural mesothelioma from a viewpoint of dose distribution analysis.
abstract: OBJECTIVE
  To investigate the feasibility of boron neutron capture therapy (BNCT) for malignant pleural mesothelioma (MPM) from a viewpoint of dose distribution analysis using Simulation Environment for Radiotherapy Applications (SERA), a currently available BNCT treatment planning system.
  
  
  METHODS
  The BNCT treatment plans were constructed for 3 patients with MPM using the SERA system, with 2 opposed anterior-posterior beams. The (10)B concentrations in the tumor and normal lung in this study were assumed to be 84 and 24 ppm, respectively, and were derived from data observed in clinical trials. The maximum, mean, and minimum doses to the tumors and the normal lung were assessed for each plan. The doses delivered to 5% and 95% of the tumor volume, D(05) and D(95), were adopted as the representative dose for the maximum and minimum dose, respectively.
  
  
  RESULTS
  When the D(05) to the normal ipsilateral lung was 5 Gy-Eq, the D(95) and mean doses delivered to the normal lung were 2.2-3.6 and 3.5-4.2 Gy-Eq, respectively. The mean doses delivered to the tumors were 22.4-27.2 Gy-Eq. The D(05) and D(95) doses to the tumors were 9.6-15.0 and 31.5-39.5 Gy-Eq, respectively.
  
  
  CONCLUSIONS
  From a viewpoint of the dose-distribution analysis, BNCT has the possibility to be a promising treatment for MPM patients who are inoperable because of age and other medical illnesses.
authors.affiliation: Particle Oncology Research Center, Kyoto University, Sennan-Gun, Osaka, Japan. msuzuki@rri.kyoto-u.ac.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Masunaga
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kinashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Nagata
authors.forename: Akira
authors.initials: A
authors.lastname: Maruhashi
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
mesh_terms: D001896:Boron Compounds / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D005240:Feasibility Studies; D006801:Humans; D008168:Lung; D008654:Mesothelioma / Q000532:radiotherapy*; D010997:Pleural Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage
chemical_list: D001896:Boron Compounds