Effect of a tomato drink intervention on insulin-like growth factor (IGF)-1 serum levels in healthy subjects.
There is concern that dietary factors can modulate the insulin-like growth factor (IGF) system. The aim of this work was to evaluate the effect of a tomato drink intervention providing small amounts of lycopene and other carotenoids on serum levels of IGF-1. Twenty healthy young subjects participated in a repeated measure double-blind, cross-over design. Subjects consumed 250 ml of a tomato drink or a placebo drink for 26 days separated by 26 days wash-out. The tomato drink intake increased plasma lycopene, phytoene, phytofluene, and beta-carotene concentrations by 0.22, 0.12, 0.13, and 0.18 micromol/L, respectively (P < 0.05). No significant effect of the tomato drink intake on IGF-1 levels was observed. However, changes in lycopene before and after each experimental period were inversely and significantly correlated with those of IGF-1 (r = -0.33, P < 0.05, N = 20). No correlation was found with the other carotenoids. A significant reduction of IGF-1 serum level (-5.7%) was observed in subjects (n = 11) with the highest plasma lycopene response but also IGF-1 levels following the tomato drink intake (P < 0.05). No effect was evident after the placebo treatment. The results suggest that further exploration of the role of tomato lycopene on IGF-1 modulation both on healthy and on subjects at risk is necessary.
Riso
Patrizia
P
Department of Food Science and Microbiology, Division of Human Nutrition, University of Milan, Italy. patrizia.riso@unimi.it
Brusamolino
Antonella
A
Martinetti
Antonia
A
Porrini
Marisa
M
D000328:Adult; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001628:Beverages; D002338:Carotenoids / Q000097:blood / Q000494:pharmacology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000187:drug effects* / Q000378:metabolism*; D000077276:Lycopene; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D019207:beta Carotene / Q000097:blood / Q000494:pharmacology
D000975:Antioxidants; D019207:beta Carotene; D002338:Carotenoids; D007334:Insulin-Like Growth Factor I; C003140:phytofluene; C100185:(all-E) phytoene; D000077276:Lycopene