Continuing efforts on the improvement of Beckmann rearrangement of indanone oxime.
Continuing search for beneficial additive toward the Beckmann rearrangement (BR) of indanone oxime has revealed that common Lewis acid catalyst in methanesulfonyl chloride (MsCl) showed increasing efficiency in this ionic rearrangement. The new protocol with MsCl is superior to the classical phosphorus-based methods such as PPA and Eaton reagent, especially in the reaction of indanone oximes.
Torisawa
Yasuhiro
Y
Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Naka-Orui, Takasaki, Gunma 370-0033, Japan. torisawa@takasaki-u.ac.jp
Nishi
Takao
T
Minamikawa
Jun-ichi
J
D000577:Amides / Q000737:chemistry; D002384:Catalysis; D007189:Indans / Q000138:chemical synthesis*; D008698:Mesylates; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents
D000577:Amides; D007189:Indans; D008698:Mesylates; D010091:Oximes; D012997:Solvents; C518621:indanone oxime; C030209:methanesulfonyl chloride