title: Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic.
abstract: We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistance. MDR strains in Bangui may emerge preferentially from a single, MDR-prone family.
authors.affiliation: Institut Pasteur, Paris, France.
authors.forename: Laurent X
authors.initials: LX
authors.lastname: Nouvel
authors.forename: Eric
authors.initials: E
authors.lastname: Kassa-Kelembho
authors.forename: Tiago
authors.initials: T
authors.lastname: Dos Vultos
authors.forename: Germain
authors.initials: G
authors.lastname: Zandanga
authors.forename: Jean
authors.initials: J
authors.lastname: Rauzier
authors.forename: Carmen
authors.initials: C
authors.lastname: Lafoz
authors.forename: Carlos
authors.initials: C
authors.lastname: Martin
authors.forename: Jesus
authors.initials: J
authors.lastname: Blazquez
authors.forename: Antoine
authors.initials: A
authors.lastname: Talarmin
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gicquel
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002488:Central African Republic / Q000453:epidemiology; D004260:DNA Repair; D012321:DNA-Directed RNA Polymerases; D006801:Humans; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D009841:Oligonucleotides / Q000032:analysis; D020641:Polymorphism, Single Nucleotide; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D009841:Oligonucleotides; C505805:rpoB protein, Mycobacterium tuberculosis; D012321:DNA-Directed RNA Polymerases