Molecular regulation of cytoskeletal rearrangements during T cell signalling.
Regulation of the cytoskeleton in cells of the haematopoietic system is essential for fulfilling diverse tasks such as migration towards a chemoattractant, phagocytosis or cell-cell communication. This is particularly true for the many types of T cells, which are at the foundation of the adaptive immune system in vertebrates. Deregulation of actin filament turnover is known to be involved in the development of severe immunodeficiencies or immunoproliferative diseases. Therefore, molecular dissection of signalling complexes and effector molecules, which leads to controlled cytoskeletal assembly, has been the focus of immunological research in the last decade. In the past, cytoskeletal remodelling was frequently understood as the finish line of signalling, while today it becomes increasingly evident that actin and microtubule dynamics are required for proper signal transmission in many processes such as T cell activation. Significant effort is made in many laboratories to further elucidate the contribution of cytoskeletal remodelling to immune function. The objective of this article is to summarise the current knowledge on how actin and microtubules are reorganised to support the formation of structures as diverse as the immunological synapse and peripheral protrusions during cell migration.
Stradal
Theresia E B
TE
Signalling and Motility Group, German Research Centre for Biotechnology (GBF), Braunschweig, Germany.
Pusch
Rico
R
Kliche
Stefanie
S
D008841:Actin Cytoskeleton / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D000818:Animals; D018106:CD28 Antigens / Q000378:metabolism; D003599:Cytoskeleton / Q000276:immunology* / Q000378:metabolism; D005544:Forecasting; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014404:Tubulin / Q000378:metabolism
D000199:Actins; D018106:CD28 Antigens; D011948:Receptors, Antigen, T-Cell; D014404:Tubulin