title: Cytotoxic hypothemycin analogues from Hypomyces subiculosus.
abstract: Three new hypothemycin analogues were isolated from the fungal strains Hypomyces subiculosus DSM 11931 and DSM 11932. The structures of these compounds were elucidated by spectroscopic methods, chemical conversion, and X-ray crystallographic analysis. One of the analogues, 4-O-demethylhypothemycin, exhibited potent and selective cytotoxic activity against cell lines with a BRAF mutation.
authors.affiliation: Kosan Biosciences, Inc., Hayward, California 94545, USA. lau@kosan.com
authors.forename: Janice L
authors.initials: JL
authors.lastname: Wee
authors.forename: Kurt
authors.initials: K
authors.lastname: Sundermann
authors.forename: Peter
authors.initials: P
authors.lastname: Licari
authors.forename: Jorge
authors.initials: J
authors.lastname: Galazzo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009154:Mutation; D015025:Zearalenone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; C120440:hypothemycin; D015025:Zearalenone