title: Human leucocyte antigen-C in B chronic lymphocytic leukaemia.
abstract: This study aimed at characterising the distribution of human leucocyte antigen (HLA)-C alleles in a large group of patients with B chronic lymphocytic leukaemia from Southeastern Spain. Ninety-eight adult patients and 194 geographically and ethnically matched controls were studied. HLA-C was determined by polymerase chain reaction sequence-specific primers (PCR-SSP) and PCR-sequence-specific oligonucleotides (SSO) methods. The HLA-Cw*16 allele frequency was found to be significantly increased amongst patients compared with controls in our population (27.6% vs. 12.4%, P = 0.0012, Pc = 0.016). HLA-C dimorphism was also analysed but no association was found.
authors.affiliation: Department of Immunology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Montes-Ares
authors.forename: M Rosa
authors.initials: MR
authors.lastname: Moya-Quiles
authors.forename: María
authors.initials: M
authors.lastname: Montes-Casado
authors.forename: Natalia
authors.initials: N
authors.lastname: Guerra-Pérez
authors.forename: J Antonio
authors.initials: JA
authors.lastname: Campillo
authors.forename: Consuelo
authors.initials: C
authors.lastname: González
authors.forename: Antonio
authors.initials: A
authors.lastname: López-Bermejo
authors.forename: Manuel
authors.initials: M
authors.lastname: Tamayo
authors.forename: M Juliana
authors.initials: MJ
authors.lastname: Majado
authors.forename: Antonio
authors.initials: A
authors.lastname: Parrado
authors.forename: Manuel
authors.initials: M
authors.lastname: Muro
authors.forename: Luis
authors.initials: L
authors.lastname: Marín
authors.forename: M Rocío
authors.initials: MR
authors.lastname: Alvarez-López
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods
chemical_list: D015236:HLA-C Antigens