Quantitative-trait-locus mapping in the presence of locus heterogeneity.
Locus heterogeneity is a concern for quantitative trait locus mapping where phenotypes are likely to be influenced by more than one gene. We introduce a model which generalizes the locus heterogeneity model of Smith (1961) from dichotomous traits to quantitative traits and consider some test statistics for this model. The type I error rates and the power of these statistics are assessed through simulation studies. These statistics are applied to a linkage study of asthma genes.
Wang
K
K
Program in Public Health Genetics, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA. kai-wang@uiowa.edu
Peng
Y
Y
D001249:Asthma / Q000235:genetics; D002874:Chromosome Mapping; D003198:Computer Simulation; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D006801:Humans; D015233:Models, Statistical; D040641:Quantitative Trait Loci