Slight and short-lasting increase of serum S-100B protein in extra-cranial trauma.
OBJECTIVE
Serum S-100B protein is an established biochemical marker of traumatic brain injury. At the same time, the question of extra-cranial S-100B release has been raised. This study evaluates the post-traumatic and post-operative release kinetics of S-100B in 45 trauma victims without head injury.


METHODS
Serum S-100B protein was measured on admission and every 24 hours for 4 consecutive days.


RESULTS
Initial S-100B was slightly increased (median: 0.54 microg L-1) and correlated with the severity of extra-cranial trauma (p = 0.0004, Mann-Whitney test). Both severely (abdominal or chest trauma with or without bone fractures) and mildly (long bone fractures) injured showed a rapid decline of S-100B (< 0.2 microg L-1) around 72 hours post-trauma. Extra-cranial surgery caused a secondary increase of S-100B, especially in the mildly injured group (p = 0.004, Wilcoxon signed rank test).


CONCLUSIONS
Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury).
Korfias
Stefanos
S
Department of Neurosurgery, University of Athens, Evangelismos Hospital, Athens, Greece. skorfias@mail.gr
Stranjalis
George
G
Psachoulia
Christina
C
Vasiliadis
Constantinos
C
Pitaridis
Marinos
M
Boviatsis
Efstathios
E
Sakas
Damianos E
DE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood* / Q000601:surgery; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D018709:Statistics, Nonparametric; D013997:Time Factors; D015599:Trauma Severity Indices
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins