[Effects of Yunnan Baiyao on peri-operative bleeding of patients undergoing cervical open-door laminoplasty: a multi-center randomized double-blind placebo-control trial].
OBJECTIVE
To investigate the effects of Yunnan Baiyao on peri-operative bleeding of the patients undergoing cervical open-door laminoplasty.


METHODS
197 patients undergoing cervical open-door laminoplasty were randomly divided into 2 groups Yunnan Baiyao group (receiving Yunnan Baiyao 500 mg three times daily for 5 days) and placebo group. The amounts of intra-operative and post-operative bleeding were compared, and the side effect of Yunnan Baiyao was also analyzed.


RESULTS
Statistical analysis showed that the amount of intra-operative bleeding of the Yunnan Baiyao was 350 ml +/- 190 ml, significantly lower than that of the placebo group (443 ml +/- 266 ml, P < 0.05). There were no statistical differences in the amount of postoperative bleeding and side effect rate between the two groups.


CONCLUSIONS
Yunnan Baiyao is effective and safe in reducing the amount of intra-operative bleeding of cervical open-door laminoplasty.
Pan
Sheng-fa
SF
Department of Orthopedics, Third Hospital of Peking University, Beijing 100083, China.
Sun
Yu
Y
Li
Feng
F
Li
Guang-hui
GH
Jin
Da-di
DD
Zhang
Zhong-min
ZM
Luo
Zhuo-jing
ZJ
Ye
Zheng-xu
ZX
Hu
Jian-hua
JH
Qiu
Gui-xing
GX
D000328:Adult; D000368:Aged; D001178:Arthroplasty / Q000379:methods*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002574:Cervical Vertebrae; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D008517:Phytotherapy; D013128:Spinal Osteophytosis / Q000601:surgery
D004365:Drugs, Chinese Herbal