title: Do antisaccade deficits in schizophrenia provide evidence of a specific inhibitory function?
abstract: BACKGROUND
  Despite its inhibitory control requirements, antisaccade deficits have been consistently associated with working memory impairments in schizophrenia. We investigated whether variance in antisaccade performance could be better accounted for in terms of a specific inhibitory function.
  
  
  METHODS
  We assessed 48 clinically stable out-patients with schizophrenia on an antisaccade task, as well as on measures of spatial and verbal working memory, sustained selective attention, and a simple motoric go/no-go measure of response inhibition.
  
  
  RESULTS
  In a stepwise multiple regression analysis, go/no-go task performance accounted for a considerably greater percentage of variance in antisaccade performance (25.3%) than either working memory (8.4%) or sustained selective attention task (9.1%).
  
  
  CONCLUSIONS
  We conclude that antisaccade deficits in schizophrenia appear to be better understood in terms of a specific deficit of inhibitory control than in terms of more general difficulties with context maintenance or goal neglect.
authors.affiliation: Neuropsychiatric Genetics Research Group, Department of Psychiatry, & Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland. donoghug@tcd.ie
authors.forename: Gary
authors.initials: G
authors.lastname: Donohoe
authors.forename: Richard
authors.initials: R
authors.lastname: Reilly
authors.forename: Sarah
authors.initials: S
authors.lastname: Clarke
authors.forename: Stephen
authors.initials: S
authors.lastname: Meredith
authors.forename: Barry
authors.initials: B
authors.lastname: Green
authors.forename: Derek
authors.initials: D
authors.lastname: Morris
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
authors.forename: Aiden
authors.initials: A
authors.lastname: Corvin
authors.forename: Hugh
authors.initials: H
authors.lastname: Garavan
authors.forename: Ian H
authors.initials: IH
authors.lastname: Robertson
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D002755:Choice Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010468:Perceptual Disorders / Q000209:etiology*; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications*; D013028:Space Perception / Q000502:physiology; D014705:Verbal Behavior / Q000502:physiology