title: [Effects of Yunnan Baiyao on peri-operative bleeding of patients undergoing cervical open-door laminoplasty: a multi-center randomized double-blind placebo-control trial].
abstract: OBJECTIVE
  To investigate the effects of Yunnan Baiyao on peri-operative bleeding of the patients undergoing cervical open-door laminoplasty.
  
  
  METHODS
  197 patients undergoing cervical open-door laminoplasty were randomly divided into 2 groups Yunnan Baiyao group (receiving Yunnan Baiyao 500 mg three times daily for 5 days) and placebo group. The amounts of intra-operative and post-operative bleeding were compared, and the side effect of Yunnan Baiyao was also analyzed.
  
  
  RESULTS
  Statistical analysis showed that the amount of intra-operative bleeding of the Yunnan Baiyao was 350 ml +/- 190 ml, significantly lower than that of the placebo group (443 ml +/- 266 ml, P < 0.05). There were no statistical differences in the amount of postoperative bleeding and side effect rate between the two groups.
  
  
  CONCLUSIONS
  Yunnan Baiyao is effective and safe in reducing the amount of intra-operative bleeding of cervical open-door laminoplasty.
authors.affiliation: Department of Orthopedics, Third Hospital of Peking University, Beijing 100083, China.
authors.forename: Sheng-fa
authors.initials: SF
authors.lastname: Pan
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Guang-hui
authors.initials: GH
authors.lastname: Li
authors.forename: Da-di
authors.initials: DD
authors.lastname: Jin
authors.forename: Zhong-min
authors.initials: ZM
authors.lastname: Zhang
authors.forename: Zhuo-jing
authors.initials: ZJ
authors.lastname: Luo
authors.forename: Zheng-xu
authors.initials: ZX
authors.lastname: Ye
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Hu
authors.forename: Gui-xing
authors.initials: GX
authors.lastname: Qiu
mesh_terms: D000328:Adult; D000368:Aged; D001178:Arthroplasty / Q000379:methods*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002574:Cervical Vertebrae; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D008517:Phytotherapy; D013128:Spinal Osteophytosis / Q000601:surgery
chemical_list: D004365:Drugs, Chinese Herbal