title: Kojic acid and its manganese and zinc complexes as potential radioprotective agents.
abstract: The naturally occurring fungal metabolite kojic acid and its manganese and zinc complexes have been evaluated as potential radioprotectors in mice. Their toxicity and radioprotective activity (survival rate) have been determined and compared with that of WR-2721 (amifostine). The results of in vivo radioprotection showed that these compounds exhibited significant radioprotective effects against lethal dose of gamma-irradiation in mice.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. sd_emami@yahoo.com
authors.forename: Saeed
authors.initials: S
authors.lastname: Emami
authors.forename: Seyed Jalal
authors.initials: SJ
authors.lastname: Hosseinimehr
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Taghdisi
authors.forename: Shahram
authors.initials: S
authors.lastname: Akhlaghpoor
mesh_terms: D004999:Amifostine / Q000494:pharmacology; D000818:Animals; D005720:Gamma Rays; D008345:Manganese / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D011753:Pyrones; D011837:Radiation-Protective Agents; C518993:bis(kojic acid)manganese(II); C518994:bis(kojic acid)zinc(II); D008345:Manganese; C011890:kojic acid; D015032:Zinc; D004999:Amifostine