title: Food allergies and eosinophilic esophagitis--two case studies.
abstract: Eosinophilic esophagitis (EE) is a clinical-pathological disorder which is being increasingly diagnosed. It is etiologically associated with hypersensitivity to airborne allergens and/or dietary components. However, immediate hypersensitivity to foods has rarely been proven as the etiologic cause of the disorder. Two patients are presented with a history of rhinoconjunctivitis, allergic asthma, atopic dermatitis and food allergies which are currently under control and who show specific IgE to pulses and chicken respectively. These patients developed acute dysphagia and vomiting immediately after ingesting these foods and following appropriate examination were diagnosed as suffering from EE. The study also showed signs of blood hypereosinophilia while the esophageal manometry revealed a motor disorder characterized by aperistalsis and non-propulsive simultaneous waves affecting the lower two-thirds of the organ composed of smooth muscle. Topical treatment with fluticasone propionate was administered over a period of 3 months, in addition to a diet abstaining from the aforementioned foods and this led to remission of dysphagia and normalization of the endoscopic, histological and manometric studies of the esophagus. This situation remained stable for a considerable length of time after steroid treatment was discontinued, which showed that exposure to foods seemed to be the cause of the esophageal disorder. Similarly, allergies to inhalants and other digestive symptoms which appear upon immediate ingestion of the foods involved would not justify the sudden onset of dysphagia. We offer a pathophysiological explanation for the mechanisms of the disease based on the activation of eosinophils and mast cells by IgE and their ability to disturb the dynamic behavior of the neural and muscle components of the esophageal wall.
authors.affiliation: Allergy Service, Pediatric Hospital, Madrid, Spain.
authors.forename: María F
authors.initials: MF
authors.lastname: Martín-Muñoz
authors.forename: Alfredo J
authors.initials: AJ
authors.lastname: Lucendo
authors.forename: Marta
authors.initials: M
authors.lastname: Navarro
authors.forename: Antonio
authors.initials: A
authors.lastname: Letrán
authors.forename: Sonia
authors.initials: S
authors.lastname: Martín-Chávarri
authors.forename: Emilio
authors.initials: E
authors.lastname: Burgos
authors.forename: M
authors.initials: M
authors.lastname: Martín-Esteban
mesh_terms: D000293:Adolescent; D000730:Androstadienes / Q000627:therapeutic use; D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D002645:Chickens / Q000276:immunology; D003680:Deglutition Disorders / Q000276:immunology; D004802:Eosinophilia / Q000276:immunology*; D004941:Esophagitis / Q000276:immunology*; D007887:Fabaceae / Q000276:immunology; D005260:Female; D000068298:Fluticasone; D005512:Food Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007073:Immunoglobulin E; D008297:Male
chemical_list: D000730:Androstadienes; D018926:Anti-Allergic Agents; D007073:Immunoglobulin E; D000068298:Fluticasone