title: Arterial baroreflex function does not influence telomere length in kidney of rats.
abstract: OBJECTIVE
  To investigate the relationship between arterial baroreflex (ABR) function and telomere length in kidney of rats.
  
  
  METHODS
  Stroke-prone spontaneously hypertensive rats (SHR-SP) and sinoaortic denervated rats (SAD) were used as models with depressed arterial baroreflex. In the first experiments, SHR-SP rats were examined at the age of 24 weeks for both sexes and 40 weeks for female rats. In the second experiments, SAD rats were studied 4 and 35 weeks after SAD operation. Blood pressure was continuously recorded for 4 h in a conscious state. After the determination of baroreflex sensitivity (BRS), the terminal restriction fragment (TRF) of rat kidney was analyzed using Southern blot.
  
  
  RESULTS
  The TRF length was found shorter in: a) male SHR-SP compared with age-matched female SHR-SP; b) female SHR-SP 40 weeks of age compared with 24 weeks of age; c) in rats 35 weeks after operation compared with rats 4 weeks post operation in both sham-operated and SAD rats.
  
  
  CONCLUSIONS
  In SHR-SP, the TRF length did not correlate with BRS. In addition, SAD did not affect TRF length at either 4 or 35 weeks post-surgery. It may be concluded that baroreflex function does not influence the terminal restriction fragment (TRF) length in rats.
authors.affiliation: Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.
authors.forename: Xiao-fei
authors.initials: XF
authors.lastname: Zhang
authors.forename: Rui-fang
authors.initials: RF
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Fu-ming
authors.initials: FM
authors.lastname: Shen
authors.forename: Ding-feng
authors.initials: DF
authors.lastname: Su
mesh_terms: D000818:Animals; D001011:Aorta / Q000294:innervation; D017763:Autonomic Denervation; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002346:Carotid Sinus / Q000294:innervation; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000473:pathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D016615:Telomere / Q000473:pathology*