title: Lung transplantation in patients 60 years and older: results, complications, and outcomes.
abstract: BACKGROUND
  Advanced recipient age is reported to negatively affect survival after lung transplantation (LTX). We hypothesized that LTX in patients aged > or = 60 years could be performed with acceptable outcomes.
  
  
  METHODS
  We identified 182 consecutive LTX recipients from 1995 to 2005. Outcomes were analyzed and survival compared with results in recipients aged < 60, as well as with United Network for Organ Sharing (UNOS) registry outcomes for the same age and study period. Actuarial survivals were calculated by the Kaplan-Meier method.
  
  
  RESULTS
  During the study period, 29% (52/182) of LTX recipients were > or = 60 years old (range, 60 to 69 years). Median follow-up was 2.9 years (range, 0 to 10 years). All patients but one received a single lung. Indications included chronic obstructive pulmonary disease in 63% (33/52), idiopathic pulmonary fibrosis in 27% (14/52), and other in 10% (5/52). In-hospital mortality was 12% (6/52) for those aged > or = 60 compared with 7% (9/130) for those aged < 60 (p = NS). Complications included reoperation in 10% (5/52), requirement for extracorporeal membrane oxygenation in 6% (3/52), renal failure in 12% (6/52), and stroke in 4% (2/52). Actuarial survivals at 30 days, and 1, 3, and 5 years were 90% (82, 98), 86% (76, 96), 71% (56, 85), and 55% (37, 73), respectively. No significant difference in survival was observed between age cohorts for our institutional data by Kaplan-Meier analysis (p = 0.34) or by Cox proportional hazard model (p = 0.15). A significant survival advantage was noted for our institution compared with UNOS for this cohort (p = 0.018).
  
  
  CONCLUSIONS
  In carefully selected recipients > or = 60 years of age, LTX offers acceptable outcomes and survival.
authors.affiliation: Department of Surgery, University of Virginia, Charlottesville, Virginia 22908-0679, USA.
authors.forename: Philip W
authors.initials: PW
authors.lastname: Smith
authors.forename: Hongkun
authors.initials: H
authors.lastname: Wang
authors.forename: Vamsi
authors.initials: V
authors.lastname: Parini
authors.forename: Jason S
authors.initials: JS
authors.lastname: Zolak
authors.forename: K Robert
authors.initials: KR
authors.lastname: Shen
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Daniel
authors.forename: Mark K
authors.initials: MK
authors.lastname: Robbins
authors.forename: Curtis G
authors.initials: CG
authors.lastname: Tribble
authors.forename: Irving L
authors.initials: IL
authors.lastname: Kron
authors.forename: David R
authors.initials: DR
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000601:surgery; D016040:Lung Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome