title: Bioactive guaianolides from siyekucai (Ixeris chinensis).
abstract: Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization are also reported. Chinenciolide E (6) showed significant growth inhibitory activity toward VA-13 malignant lung tumor cells (IC50 = 0.72 microM).
authors.affiliation: Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata, 950-2181, Japan.
authors.forename: Shujun
authors.initials: S
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Liming
authors.initials: L
authors.lastname: Bai
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Jinlan
authors.initials: J
authors.lastname: Wang
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Xue
authors.forename: Qigang
authors.initials: Q
authors.lastname: Deng
authors.forename: Fenglan
authors.initials: F
authors.lastname: Xing
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Bai
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Sakai
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
authors.forename: Rei
authors.initials: R
authors.lastname: Koyanagi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tsukumo
authors.forename: Takao
authors.initials: T
authors.lastname: Kataoka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagai
authors.forename: Katutoshi
authors.initials: K
authors.lastname: Hirose
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ando
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000187:drug effects; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D045789:Sesquiterpenes, Guaiane; C515177:chinensiolide D; C515178:chinensiolide E; D018799:Intercellular Adhesion Molecule-1