title: Potent antitumor activity of 3,4-seco-8betaH-Ferna-4(23),9(11)-dien-3-oic acid (EC-2) and 3,4-seco-Oleana-4(23),18-dien-3-oic acid (EC-4), evaluated by an in vitro human cancer cell line panel.
abstract: 3,4-seco-8beta H-Ferna-4(23),9(11)-dien-3-oic acid (EC-2) (1) and 3,4-seco-oleana-4(23),18-dien-3-oic acid (EC-4) (2) isolated from the whole herb of Euphorbia chamaesyce L. were evaluated for their anti-tumor activities using a panel including 39 human cancer cell lines (HCC) coupled with a drug sensitivity database. Compounds 1 and 2 showed strong cytotoxicity against the HCC panel, even though alcohols 1A and 2A and methyl esters 1B and 2B were inactive.
authors.affiliation: Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan. tanakar@gly.oups.ac.jp
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Wada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Takao
authors.initials: T
authors.lastname: Yamori
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D028481:Euphorbia; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts