Noniosides E - H, new trisaccharide fatty acid esters from the fruit of Morinda citrifolia (Noni).
Four new trisaccharide fatty acid esters named noniosides E - H ( 4 - 7) were isolated from the fruit of Morinda citrifolia (Noni) by a combination of Sephadex LH-20, high-speed countercurrent chromatography (HSCCC) and semipreparative HPLC. Their structures were elucidated by high resolution mass spectrometry and 1D- and 2D-NMR as 2,6-di- O-(beta-D-glucopyranosyl)-1-O-hexanoyl-beta-D-glucopyranose (4), 2,6-di-O-(beta-D-glucopyranosyl)-1-O-decanoyl-beta-D-glucopyranose (5), 2-O-(6-O-octanoyl-beta-D-glucopyranosyl)-6-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose (6), and 2-O-(6-O-hexanoyl-beta-D-glucopyranosyl)-6-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose or 2-O-(6-O-octanoyl-beta-D-glucopyranosyl)-6-O-(beta-D-glucopyranosyl)-1-O-hexanoyl-beta-D-glucopyranose (7), respectively. In addition, an HPLC-MS analysis of a methanolic extract of the fruit powder revealed the presence of further derivatives including new disaccharide and trisaccharide esters with fatty acid residues of various lengths.
Dalsgaard
Petur W
PW
Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland.
Potterat
Olivier
O
Dieterle
Fiona
F
Paululat
Thomas
T
Kühn
Till
T
Hamburger
Matthias
M
D002851:Chromatography, High Pressure Liquid; D004952:Esters / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D005638:Fruit; D006017:Glycolipids / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D032066:Morinda; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D014312:Trisaccharides / Q000737:chemistry
D004952:Esters; D005227:Fatty Acids; D006017:Glycolipids; D010936:Plant Extracts; D014312:Trisaccharides