[Solubilities of ephedrine and d-pseudo-ephedrine from different sizes of ultramicro-particles of the compound traditional Chinese herbs Maxing Shigan decoction].
OBJECTIVE
To compare the solubilities of ephedrine and d-pseudo-ephdrine in the compound of traditional Chinese drugs--Maxing Shigan decoction with and without ultramicro-pulverizations using a RP-HPLC procedure.


METHODS
The analytical column was a YMC ODS-C18(4.6 mm x 150 mm,4 microm). A mixture of water-acetonitrile-sodium dodecyl sulfate-phosphorous acid (650:350:5:1) was used as the mobile phase at flow rate of 1.5 mL x min(-1). The column temperature was 50 degrees C and the wavelength was 210 nm.


RESULTS
In this way, ephedrine and d-pseudo-ephedrine of the compound samples can be separated well and showed significant differences before and after the ultramicro-pulverizations.


CONCLUSIONS
For the Maxing Shigan decoction, the dissolution rates and solubilites of ephedrine and d-pseudo-ephedrine ultramicro-pulverization were greatly improved.
Si
Nan
N
Institute of Chinese Material Medica, China Academy of Chinese Medicial Sciences, Beijing 100700, China.
Yang
Jian
J
Bian
Bao-lin
BL
D002133:Calcium Sulfate / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D029789:Ephedra / Q000737:chemistry; D004809:Ephedrine / Q000032:analysis* / Q000737:chemistry; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry*; D011208:Powders; D027861:Prunus / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011208:Powders; D004809:Ephedrine; D002133:Calcium Sulfate