title: Development of dose delivery verification by PET imaging of photonuclear reactions following high energy photon therapy.
abstract: A method for dose delivery monitoring after high energy photon therapy has been investigated based on positron emission tomography (PET). The technique is based on the activation of body tissues by high energy bremsstrahlung beams, preferably with energies well above 20 MeV, resulting primarily in 11C and 15O but also 13N, all positron-emitting radionuclides produced by photoneutron reactions in the nuclei of 12C, 16O and 14N. A PMMA phantom and animal tissue, a frozen hind leg of a pig, were irradiated to 10 Gy and the induced positron activity distributions were measured off-line in a PET camera a couple of minutes after irradiation. The accelerator used was a Racetrack Microtron at the Karolinska University Hospital using 50 MV scanned photon beams. From photonuclear cross-section data integrated over the 50 MV photon fluence spectrum the predicted PET signal was calculated and compared with experimental measurements. Since measured PET images change with time post irradiation, as a result of the different decay times of the radionuclides, the signals from activated 12C, 16O and 14N within the irradiated volume could be separated from each other. Most information is obtained from the carbon and oxygen radionuclides which are the most abundant elements in soft tissue. The predicted and measured overall positron activities are almost equal (-3%) while the predicted activity originating from nitrogen is overestimated by almost a factor of two, possibly due to experimental noise. Based on the results obtained in this first feasibility study the great value of a combined radiotherapy-PET-CT unit is indicated in order to fully exploit the high activity signal from oxygen immediately after treatment and to avoid patient repositioning. With an RT-PET-CT unit a high signal could be collected even at a dose level of 2 Gy and the acquisition time for the PET could be reduced considerably. Real patient dose delivery verification by means of PET imaging seems to be applicable provided that biological transport processes such as capillary blood flow containing mobile 15O and 11C in the activated tissue volume can be accounted for.
authors.affiliation: Medical Radiation Physics, Department of Oncology and Pathology, Karolinska Institutet and Stockholm University, 171 76 Stockholm, Sweden. sara.janek@ki.se
authors.forename: S
authors.initials: S
authors.lastname: Janek
authors.forename: R
authors.initials: R
authors.lastname: Svensson
authors.forename: C
authors.initials: C
authors.lastname: Jonsson
authors.forename: A
authors.initials: A
authors.lastname: Brahme
mesh_terms: D000818:Animals; D001822:Body Burden; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D018499:Linear Energy Transfer; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D009928:Organ Specificity; D019047:Phantoms, Imaging; D017785:Photons / Q000627:therapeutic use*; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods; D011882:Radiotherapy, High-Energy / Q000379:methods*; D013552:Swine; D016896:Treatment Outcome