title: [Cutaneous necrosis due to interferon alpha in a patient with melanoma].
abstract: We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN.
authors.affiliation: Servicio de Dermatología, Hospital Clínico Universitario San Cecilio, Granada, España. guadaguilar@hohtmail.com
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Aguilar García
authors.forename: Cristina
authors.initials: C
authors.lastname: Serrano Falcón
authors.forename: Maria del Mar
authors.initials: Mdel M
authors.lastname: Serrano Falcón
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: Carmona
authors.forename: Juan
authors.initials: J
authors.lastname: Linares Solano
authors.forename: Salvio
authors.initials: S
authors.lastname: Serrano Ortega
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001132:Arm; D017024:Chemotherapy, Adjuvant; D003646:Debridement; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced* / Q000473:pathology; D009824:Ointments; D011994:Recombinant Proteins; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012883:Skin Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000601:surgery; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009824:Ointments; D011994:Recombinant Proteins