Regeneration of skeletal muscles and state of thymus in gamma-irradiated rats under laser therapy of the area of muscle trauma.
The gamma-irradiation of adult rats with a semi-lethal dose (6 Gy) suppressed the posttraumatic regeneration of skeletal muscles and brought about considerable destructive changes in the thymus. The effect of He-Ne laser radiation at a total dose 4.5-5.4 J/cm2 at each operated leg in irradiated rats stimulated the regenerative capacity of skeletal muscle tissue, the healing of skin-muscle wound, and the processes of postradiation recovery in thymus cells (a decrease of chromosome aberrations). The histological structure of regenerates had more muscle pattern. At the same time, the positive dynamics of regenerative processes in muscles was achieved by an increased functional load on the thymus. To stimulate the regeneration of irradiated muscles on the background of a more moderate load on the thymus, the prolonged period of laser therapy and fragmentary distribution of laser exposures during muscle regeneration were preferable. Wound healing improved visibly. Nor formation of chronic radiation ulcers on operated shins was observed.
Bulyakova
N V
NV
A N Severtzov Institute of Ecology & Evolution, Russian Academy of Sciences, Moscow, Russia. admin@sevin.ru
Azarova
V S
VS
D000818:Animals; D005720:Gamma Rays / Q000009:adverse effects*; D028022:Low-Level Light Therapy; D018482:Muscle, Skeletal / Q000293:injuries / Q000502:physiology* / Q000528:radiation effects; D011839:Radiation, Ionizing; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects*; D014945:Wound Healing; D014947:Wounds and Injuries / Q000534:rehabilitation*