title: Introduction to NF-kappaB: players, pathways, perspectives.
abstract: This article serves as an introduction to the collection of reviews on nuclear factor-kappaB (NF-kappaB). It provides an overview of the discovery and current status of NF-kappaB as a research topic. Described are the structures, activities and regulation of the proteins in the NF-kappaB family of transcription factors. NF-kappaB signaling is primarily regulated by inhibitor kappaB (IkappaB) proteins and the IkappaB kinase complex through two major pathways: the canonical and non-canonical NF-kappaB pathways. The organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-kappaB.
authors.affiliation: Biology Department, Boston University, Boston, MA 02215, USA. gilmore@bu.edu
authors.forename: T D
authors.initials: TD
authors.lastname: Gilmore
mesh_terms: D016328:NF-kappa B / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D009626:Terminology as Topic
chemical_list: D016328:NF-kappa B