Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12.
BACKGROUND
We are interested in identifying susceptibility genes that predispose subjects to attempted suicide.


METHODS
We conducted a secondary analysis of genome-wide linkage data from 162 bipolar pedigrees that incorporated attempted suicide as a clinical covariate.


RESULTS
The strongest covariate-based linkage signal was seen on 2p12 at marker D2S1777. The logarithm of odds (LOD) score at marker D2S1777 rose from 1.56 to 3.82 after inclusion of the suicide covariate, resulting in significant chromosome-wide empirically derived p-values for the overall linkage finding (p = .01) and for the change in LOD score after the inclusion of the covariate (p = .02).


CONCLUSIONS
The finding on chromosome 2 replicates results from two previous studies of attempted suicide in pedigrees with alcohol dependence and in pedigrees with recurrent early-onset depression. Combined, these three studies provide compelling evidence for a locus influencing attempted suicide on 2p12.
Willour
Virginia L
VL
Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. willour@jhmi.edu
Zandi
Peter P
PP
Badner
Judith A
JA
Steele
Jo
J
Miao
Kuangyi
K
Lopez
Victor
V
MacKinnon
Dean F
DF
Mondimore
Francis M
FM
Schweizer
Barbara
B
McInnis
Melvin G
MG
Miller
Erin B
EB
Depaulo
J Raymond
JR
Gershon
Elliot S
ES
McMahon
Francis J
FJ
Potash
James B
JB
D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D010375:Pedigree; D018709:Statistics, Nonparametric; D013406:Suicide, Attempted