title: Community annotation: procedures, protocols, and supporting tools.
abstract: Investigators at the Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC) and BeeBase organized a community-wide effort to manually annotate the honey bee (Apis mellifera) genome. Although various strategies for manual annotation have been used in the past, the value of dispersed community annotation has not yet been demonstrated. Here we make a case for the merit of dispersed community annotation. We present annotation procedures, standard protocols, and tools used for sequence analysis, data submission, and data management. We also report lessons learned from this dispersed community annotation effort for a metazoan genome.
authors.affiliation: Department of Animal Science, Texas A&M University, College Station, Texas 77843, USA.
authors.forename: Christine G
authors.initials: CG
authors.lastname: Elsik
authors.forename: Kim C
authors.initials: KC
authors.lastname: Worley
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Milshina
authors.forename: Huaiyang
authors.initials: H
authors.lastname: Jiang
authors.forename: Justin T
authors.initials: JT
authors.lastname: Reese
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Childs
authors.forename: Anand
authors.initials: A
authors.lastname: Venkatraman
authors.forename: C Michael
authors.initials: CM
authors.lastname: Dickens
authors.forename: George M
authors.initials: GM
authors.lastname: Weinstock
authors.forename: Richard A
authors.initials: RA
authors.lastname: Gibbs
mesh_terms: D000818:Animals; D001516:Bees / Q000235:genetics; D030541:Databases, Genetic; D015894:Genome, Human; D023281:Genomics / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D017421:Sequence Analysis