The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women.
Common genetic variants in cancer-related genes contribute to breast cancer. The innate immune system plays a crucial role in the immune surveillance against malignancies, thus it is plausible that genetic variations in key genes of the innate immunity such as the mannose-binding lectin (MBL), MBL2, could influence the risk for breast cancer. We investigated the association of MBL2 genotypes with breast cancer and conducted a comprehensive genotype and haplotype analysis of 26 MBL2 single nucleotide polymorphisms (SNPs) in a case-control study of breast cancer [166 African-American (AA) case patients versus 180 controls and 127 Caucasian (CAU) case patients versus 137 controls]. We observed that the A allele of the 3'-UTR SNP Ex4-1067 (NCBI SNP ID: rs10824792) was significantly associated with a decreased disease risk in AA women [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.27-0.81]. Haplotype analysis of MBL2 showed that the frequency of the corresponding 3' haplotype TATAAC (Ex4-1483, Ex4-1067, Ex4-1047, Ex4-901, Ex4-710, 3238bp 3' STP) was lower in cases than controls among AA women (0.15 versus 0.21; P = 0.02) suggesting a protective effect after adjusting for covariates (OR = 0.51, 95% CI = 0.29-0.88, P = 0.018). In conclusion, this study presents preliminary evidence that common genetic variants in the 3'-UTR of MBL2 might influence the risk for breast cancer in AA women, probably in interaction with the 5' secretor haplotypes that are associated with high concentrations of MBL.
Bernig
Toralf
T
Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) Bethesda, MD 20892-4258, USA.
Boersma
Brenda J
BJ
Howe
Tiffany M
TM
Welch
Robert
R
Yadavalli
Sunita
S
Staats
Brian
B
Mechanic
Leah E
LE
Chanock
Stephen J
SJ
Ambs
Stefan
S
D020413:3' Untranslated Regions / Q000235:genetics; D001741:Black or African American / Q000235:genetics*; D001943:Breast Neoplasms / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D037601:Mannose-Binding Lectin / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics*
D020413:3' Untranslated Regions; D005819:Genetic Markers; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin