cAMP phosphodiesterase activity evaluation in human carcinoma of salivary glands.
The aim of this study was to evaluate differences of cAMP-PDE activity in human salivary glands, between a control group and some different benign tumours groups and, where present, with 2 malignant tumors groups. The value of the enzymatic activity in the groups analysed was 50% lower than control samples. The differences between the control group (82 +/- 7.9 nmols/mg of protein) and the 3 pathologic groups (Benign A: 44 +/- 6.2; Malignant A: 40 +/- 16; Benign B: 40 +/- 14.2; Malign A: 9.1; Benign C: 22 nmols/mg of protein) are statistically significant.
Spoto
G
G
Department of Applied Sciences of Oral and Dental Diseases, G D'Annunzio University, Chieti, Italy. cercando_luca@hotmail.com
della Malva
M
M
Rubini
C
C
Fioroni
M
M
Piattelli
A
A
Serra
E
E
Di Nicola
M
M
Santoleri
F
F
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D002277:Carcinoma / Q000201:enzymology*; D016022:Case-Control Studies; D000242:Cyclic AMP / Q000737:chemistry; D018450:Disease Progression; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D009712:Nucleotides, Cyclic / Q000737:chemistry; D012468:Salivary Gland Neoplasms / Q000201:enzymology*; D012469:Salivary Glands / Q000201:enzymology*
D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases