Cross-talk between nuclear receptors and nuclear factor kappaB.
A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor kappaB (NF-kappaB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-kappaB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-kappaB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.
De Bosscher
K
K
Laboratory for Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Molecular Biology, Ghent University, Gent, Belgium. karolien.debosscher@ugent.be
Vanden Berghe
W
W
Haegeman
G
G
D000818:Animals; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D020239:Receptor Cross-Talk; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D015398:Signal Transduction
D006728:Hormones; D016328:NF-kappa B; D018160:Receptors, Cytoplasmic and Nuclear