Accelerated versus classical hepatitis B virus vaccination programs in healthcare workers accelerated vs. classical HBV vaccination.
BACKGROUND
The aim of this study was to compare the efficacy of a standard hepatitis B virus vaccination program (day 0-30-60) with an accelerated vaccination program (day 0-10-21) in healthy healthcare workers.


METHODS
Participants were randomly assigned to a classical (group 1, days 0, 30, and 60) or an accelerated vaccination program (group 2, days 0, 10, and 21). The vaccine used was 20 pg recombinant hepatitis B vaccine (recombinant hepatitis B vaccine derived from yeast cells, Engerix B, Smith Cline Beachum). HBV markers were re-examined for the emergence of anti-HBsAg and also to detect the development of a possible acute HBV infection one, two, and three months after the last dose of vaccine. Anti-HBsAg titers >10 mIU/l were accepted as protective.


RESULTS
The seroprotection rates were similar one, two, and three months after the last dose of vaccine in both groups. Anti-HBsAg titers in group 1 were higher than in group 2 two and three months after the last dose of vaccination (p<0.05).


CONCLUSIONS
Our data indicate that the accelerated HBV vaccination program was as effective as the classical vaccination program.
Tarhan
Mustafa Oktay
MO
Department of Internal Medicine Division of Oncology, Ataturk Training and Research Hospital, Izmir, Turkey.
Aker
All Ihsan
AI
Sipahi
Oguz Resat
OR
Kardes
Gokhan
G
Biberoglu
Kadir
K
D000328:Adult; D005260:Female; D006282:Health Personnel; D006509:Hepatitis B / Q000517:prevention & control* / Q000821:virology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006515:Hepatitis B virus / Q000378:metabolism*; D006801:Humans; D017589:Immunization Programs; D007115:Immunization Schedule; D016273:Occupational Exposure; D013997:Time Factors; D014611:Vaccination
C075654:Engerix-B; D017325:Hepatitis B Vaccines