title: Antimicrobial emulsion (coating) based on biopolymer containing neem (Melia azardichta) and turmeric (Curcuma longa) extract for wound covering.
abstract: Polymeric bio-adhesives emulsion which is biodegradable and non-toxic containing antimicrobial agents can play an important role in preventing infection in wound covering and coating for surgical implants. Therefore a bioadhesive polymer was synthesized by semi-Interpenetrating Network process using blend of shellac, casein and polyvinyl alcohol and Maleic anhydride (MA) as reactive compatibilizer. The synthesized polymer was mixed with neem and turmeric extract and homogenized using an emulsifier. Differential scanning calorimeter (DSC) was used to measure the molecular miscibility of biopolymer components and emulsion constituents. Stability of emulsion (coating) was measured by keeping property and accelerated stability test. Antimicrobial properties were evaluated for human pathogenic organisms namely E. coli, Staphylococcus aureus, Bacillus cereus, and Salmonella typhimurium using well diffusion assay. The results indicate that stability, miscibility and antimicrobial properties of bioadhesive was satisfactory, however further in vivo studies are required to ascertain suitability of emulsion (coating) for biomedical use.
authors.affiliation: Defence Bioengineering and Electrochemical Laboratory, Bangalore, India. mursradhika@yahoo.co.in
authors.forename: J H
authors.initials: JH
authors.lastname: Jagannath
authors.forename: M
authors.initials: M
authors.lastname: Radhika
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects*; D001458:Bandages; D001704:Biopolymers / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000737:chemistry; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D005989:Glycerides / Q000008:administration & dosage* / Q000737:chemistry*; D008422:Materials Testing; D013729:Terpenes / Q000008:administration & dosage* / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D001704:Biopolymers; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D004655:Emulsions; D005989:Glycerides; D013729:Terpenes; C002443:neem oil; D003474:Curcumin