title: Endophthalmitis after open globe injury: microbiologic spectrum and susceptibilities of isolates.
abstract: OBJECTIVE
  To present the microbiologic spectrum and susceptibilities of isolates in posttraumatic endophthalmitis, and to provide a review of the literature.
  
  
  METHODS
  Retrospective consecutive case series.
  
  
  METHODS
  A review of 1182 consecutive open globe injuries was performed, identifying 10 patients with culture-proven endophthalmitis.
  
  
  RESULTS
  Thirteen organisms were isolated from 10 eyes with posttraumatic endophthalmitis. Isolated organisms included Streptococcus species (46.2%), coagulase-negative Staphylococcus (23.1%), and Bacillus cereus (15.4%). All organisms tested were susceptible to vancomycin and tobramycin. The most commonly isolated organisms from an aggregate posttraumatic endophthalmitis pool of 372 cases obtained by literature-based meta-analysis were coagulase-negative Staphylococcus (21.5%) and Bacillus cereus (18.5%).
  
  
  CONCLUSIONS
  We report a high prevalence of gram-positive pathogens and a notable prevalence of Bacillus cereus in posttraumatic endophthalmitis. Susceptibility results suggest that posttraumatic endophthalmitis isolates are generally susceptible to vancomycin and tobramycin.
authors.affiliation: Wills Eye Retina Service, Philadelphia, Pennsylvania 19107, USA. derek_kunimoto@yahoo.com
authors.forename: Sachin
authors.initials: S
authors.lastname: Chhabra
authors.forename: Derek Y
authors.initials: DY
authors.lastname: Kunimoto
authors.forename: Lubna
authors.initials: L
authors.lastname: Kazi
authors.forename: Carl D
authors.initials: CD
authors.lastname: Regillo
authors.forename: Allen C
authors.initials: AC
authors.lastname: Ho
authors.forename: Jonathan
authors.initials: J
authors.lastname: Belmont
authors.forename: Joseph
authors.initials: J
authors.lastname: Maguire
authors.forename: James
authors.initials: J
authors.lastname: Vander
authors.forename: Gary C
authors.initials: GC
authors.lastname: Brown
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001082:Aqueous Humor / Q000382:microbiology; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D024881:Drug Resistance, Bacterial; D009877:Endophthalmitis / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000382:microbiology*; D015807:Eye Injuries, Penetrating / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D014822:Vitreous Body / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents