title: Isolated donor specific alloantibody-mediated rejection after ABO compatible liver transplantation.
abstract: Antibody-mediated rejection (AMR) after liver transplantation is recognized in ABO incompatible and xeno-transplantation, but its role after ABO compatible liver transplantation is controversial. We report a case of ABO compatible liver transplantation that demonstrated clinical, serological and histological signs of AMR without evidence of concurrent acute cellular rejection. AMR with persistently high titers of circulating donor specific antibodies resulted in graft injury with initial centrilobular hepatocyte necrosis, fibroedematous portal expansion mimicking biliary tract outflow obstruction, ultimately resulting in extensive bridging fibrosis. Immunofluorescence microscopy demonstrated persistent, diffuse linear C4d deposits along sinusoids and central veins. Despite intense therapeutic intervention including plasmapheresis, IVIG and rituximab, AMR led to graft failure. We present evidence that an antibody-mediated alloresponse to an ABO compatible liver graft can cause significant graft injury independent of acute cellular rejection. AMR shows distinct histologic changes including a characteristic staining profile for C4d.
authors.affiliation: Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: R
authors.initials: R
authors.lastname: Watson
authors.forename: T
authors.initials: T
authors.lastname: Kozlowski
authors.forename: V
authors.initials: V
authors.lastname: Nickeleit
authors.forename: J T
authors.initials: JT
authors.lastname: Woosley
authors.forename: J L
authors.initials: JL
authors.lastname: Schmitz
authors.forename: S L
authors.initials: SL
authors.lastname: Zacks
authors.forename: J H
authors.initials: JH
authors.lastname: Fair
authors.forename: D A
authors.initials: DA
authors.lastname: Gerber
authors.forename: K A
authors.initials: KA
authors.lastname: Andreoni
mesh_terms: D000017:ABO Blood-Group System; D001787:Blood Group Incompatibility / Q000276:immunology; D005260:Female; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D016031:Liver Transplantation / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged
chemical_list: D000017:ABO Blood-Group System; D007518:Isoantibodies