Regenerative inductive therapy based on DDS technology of protein and gene.
Recent development of biomedical engineering including biomaterials and drug delivery system (DDS) as well as basic biology and medicine has enabled cells to induce regeneration repairing of defective tissues as well as substitute the biological functions of damaged organs. For successful tissue regeneration, it is undoubtedly indispensable to give cells a local environment which allows cells to efficiently promote their proliferation and differentiation and consequently induce cell-based tissue regeneration. Tissue engineering is one of the biomedical forms to create this regeneration environment of cells. The tissue and organ repairing based on their regeneration induction has been realized by combining cells with the tissue engineering technology or methodology in a surgical or internally medical manner. This paper overviews the present status and future direction of tissue engineering for regenerative inductive therapy, briefly explaining the key technology of tissue engineering, especially DDS of growth factor and gene.
Tabata
Yasuhiko
Y
Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan. yasuhiko@frontier.kyoto-u.ac.jp
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006133:Growth Substances / Q000008:administration & dosage* / Q000235:genetics / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology; D044968:Regenerative Medicine / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends; D023822:Tissue Engineering / Q000379:methods
D006133:Growth Substances