title: Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children.
abstract: Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate. The presence of polymorphisms that reduce the activity of MTHFR has been linked to the multifactor process of development of acute leukemia. A case control study was conducted on Brazilian children in different regions of the country with the aim of investigating the role of MTHFR C677T and A1298C polymorphisms as risk factors in the development of acute myeloid leukemia (AML). We used the polymerase chain reaction restriction fragment length polymorphism method to genotyping 182 AML and 315 healthy individuals. The genotype 677 CT was associated with decreased risk [odds ratio (OR), 0.37; confidence interval (CI) 95%, 0.14 - 0.92], whereas 1298 AC genotype was linked with an increased risk [OR, 2.90; CI 95%, 1.26 - 6.71] of developing AML in non-white children. Further epidemiological study is needed to unravel the complex multiple gene-environment interactions in the role of the AML leukemogenesis.
authors.affiliation: Departamento de Genética, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Flavio Jose
authors.initials: FJ
authors.lastname: da Costa Ramos
authors.forename: Maria Tereza
authors.initials: MT
authors.lastname: Cartaxo Muniz
authors.forename: Vanessa Cavalcante
authors.initials: VC
authors.lastname: Silva
authors.forename: Marcela
authors.initials: M
authors.lastname: Araújo
authors.forename: Ednalva Pereira
authors.initials: EP
authors.lastname: Leite
authors.forename: Elizabete Malaquias
authors.initials: EM
authors.lastname: Freitas
authors.forename: Crisiane Wais
authors.initials: CW
authors.lastname: Zanrosso
authors.forename: Ana
authors.initials: A
authors.lastname: Hatagima
authors.forename: Maricilda Palandi
authors.initials: MP
authors.lastname: de Mello
authors.forename: Jose Andrés
authors.initials: JA
authors.lastname: Yunes
authors.forename: Terezinha de Jesus
authors.initials: Tde J
authors.lastname: Marques-Salles
authors.forename: Neide
authors.initials: N
authors.lastname: Santos
authors.forename: Silvia R
authors.initials: SR
authors.lastname: Brandalise
authors.forename: Maria S
authors.initials: MS
authors.lastname: Pombo-De-Oliveira
mesh_terms: D000293:Adolescent; D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics*; D012306:Risk
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)