Arterial baroreflex function does not influence telomere length in kidney of rats.
OBJECTIVE
To investigate the relationship between arterial baroreflex (ABR) function and telomere length in kidney of rats.


METHODS
Stroke-prone spontaneously hypertensive rats (SHR-SP) and sinoaortic denervated rats (SAD) were used as models with depressed arterial baroreflex. In the first experiments, SHR-SP rats were examined at the age of 24 weeks for both sexes and 40 weeks for female rats. In the second experiments, SAD rats were studied 4 and 35 weeks after SAD operation. Blood pressure was continuously recorded for 4 h in a conscious state. After the determination of baroreflex sensitivity (BRS), the terminal restriction fragment (TRF) of rat kidney was analyzed using Southern blot.


RESULTS
The TRF length was found shorter in: a) male SHR-SP compared with age-matched female SHR-SP; b) female SHR-SP 40 weeks of age compared with 24 weeks of age; c) in rats 35 weeks after operation compared with rats 4 weeks post operation in both sham-operated and SAD rats.


CONCLUSIONS
In SHR-SP, the TRF length did not correlate with BRS. In addition, SAD did not affect TRF length at either 4 or 35 weeks post-surgery. It may be concluded that baroreflex function does not influence the terminal restriction fragment (TRF) length in rats.
Zhang
Xiao-fei
XF
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.
Yang
Rui-fang
RF
Wang
Jin
J
Zhao
Lei
L
Li
Ling
L
Shen
Fu-ming
FM
Su
Ding-feng
DF
D000818:Animals; D001011:Aorta / Q000294:innervation; D017763:Autonomic Denervation; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002346:Carotid Sinus / Q000294:innervation; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000473:pathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D016615:Telomere / Q000473:pathology*