title: A comparative study of glycodelin concentrations in uterine flushings in women with subseptate uteri, history of unexplained recurrent miscarriage and healthy controls.
abstract: OBJECTIVE
  To compare the concentration of glycodelin in uterine flushing at the implantation window obtained from women with subseptate uteri, women with a history of recurrent first trimester miscarriage and fertile controls.
  
  
  METHODS
  Glycodelin concentration was assessed using Enzyme Linked Immunohistochemistry (ELISA) at The Early Pregnancy & Gynaecology Assessment Unit, King's College Hospital, London, England. Eight women with a subseptate uterus, 20 women with a history of unexplained recurrent first trimester miscarriage and 16 fertile controls had uterine cavity flushing, for glycodelin concentration, done 7 days after the luteinising hormone surge.
  
  
  RESULTS
  Glycodelin concentrations in uterine flushing obtained from women with subseptate uteri (n=8) (median 32.9 ng/ml, range 17.1-52.4 ng/ml) and recurrent miscarriage (n=20) (median 26.8 ng/ml, range 9.7-78.5 ng/ml) were significantly lower than in the control group (n=16) (median 67.7 ng/ml, range 59.0-77.6 ng/ml) (chi(2)=19.565, p<0.001).
  
  
  CONCLUSIONS
  Peri-implantation levels of glycodelin are lower in women at high risk of early pregnancy failure.
authors.affiliation: The Early Pregnancy & Gynaecology Assessment Unit, King's College Hospital, London, UK. rehan.salim@talk21.com
authors.forename: R
authors.initials: R
authors.lastname: Salim
authors.forename: J
authors.initials: J
authors.lastname: Miel
authors.forename: M
authors.initials: M
authors.lastname: Savvas
authors.forename: C
authors.initials: C
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Jurkovic
mesh_terms: D000026:Abortion, Habitual / Q000378:metabolism*; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D011257:Pregnancy Proteins / Q000378:metabolism*; D014599:Uterus / Q000002:abnormalities / Q000378:metabolism*
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins