title: Acute renal dysfunction in salmonella gastroenteritis.
abstract: OBJECTIVE
  To determine the incidence of renal function deterioration in adult patients with Salmonella infection.
  
  
  BACKGROUND
  Renal impairment has been described during severe Salmonella infection and is mainly due to shock, dehydration, or rhabdomyolysis. However, it is unclear whether less severe Salmonella infection also has an impact on kidney function.
  
  
  METHODS
  We retrospectively reviewed over a 2-year period the data of all hospitalized adult patients with microbiologically proven gastrointestinal infection. Different biologic parameters were compared between patients infected with Salmonella and patients with other gastrointestinal infections.
  
  
  RESULTS
  One hundred and seven patients with positive stool cultures were identified; 44 of them had proven Salmonella infection. Renal dysfunction, defined as an increase in serum creatinine above 1.5 mg/dL in men and above 1.3 mg/dL in women, was observed in 16 (36%) patients infected by Salmonella but only in 3 (5%) comparators (P<0.0001). Hydration status and creatine kinase levels were not different in patients affected by Salmonella as compared with other pathogens. Kidney function recovered in all but 1 patient.
  
  
  CONCLUSIONS
  Salmonella gastroenteritis in adults is frequently accompanied by renal dysfunction that is caused by mechanisms other than dehydration or rhabdomyolysis.
authors.affiliation: Department of Intensive Care, Academisch Ziekenhuis AZ-VUB, Brussels, Belgium. k.janssenvandoorn@gmail.com
authors.forename: Karin
authors.initials: K
authors.lastname: Janssen van Doorn
authors.forename: Denis
authors.initials: D
authors.lastname: Pierard
authors.forename: Herbert
authors.initials: H
authors.lastname: Spapen
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000382:microbiology* / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002169:Campylobacter Infections / Q000097:blood / Q000150:complications; D004405:Dysentery, Bacillary / Q000097:blood / Q000150:complications; D004927:Escherichia coli Infections / Q000097:blood / Q000150:complications; D005260:Female; D005759:Gastroenteritis / Q000097:blood / Q000150:complications* / Q000382:microbiology; D006471:Gastrointestinal Hemorrhage / Q000097:blood / Q000209:etiology; D006801:Humans; D015994:Incidence; D007297:Inpatients; D016015:Logistic Models; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D012107:Research Design; D012189:Retrospective Studies; D012480:Salmonella Infections / Q000097:blood / Q000150:complications*; D015009:Yersinia Infections / Q000097:blood / Q000150:complications
chemical_list: D015415:Biomarkers