title: Antinociceptive activity of the pyranocoumarin seselin in mice.
abstract: Seselin an angular pyranocoumarin at dose of 0.5, 4.5 or 40.5 mg/kg inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4%, respectively. Using the same doses, seselin elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively. Besides, a significant reduction of licking time was observed during the first phase (neurogenic) at the highest doses of seselin, by 34.4% and 66.9%, respectively. On the contrary, in the hot plate test no effect was observed after seselin treatment. In conclusion, seselin was able to inhibit inflammatory hyperalgesia, suggesting that this natural product possesses both important peripheral anti-inflammatory and antinociceptive properties.
authors.affiliation: Health Sciences Center, Course of Pharmaceutical Sciences, University of Fortaleza (UNIFOR), Fortaleza, Brazil. villima@yahoo.com.br
authors.forename: Vilma
authors.initials: V
authors.lastname: Lima
authors.forename: Caio B
authors.initials: CB
authors.lastname: Silva
authors.forename: Jair
authors.initials: J
authors.lastname: Mafezoli
authors.forename: Mirna M
authors.initials: MM
authors.lastname: Bezerra
authors.forename: M Odorico
authors.initials: MO
authors.lastname: Moraes
authors.forename: Guilherme S M M
authors.initials: GS
authors.lastname: Mourão
authors.forename: J Nunes
authors.initials: JN
authors.lastname: Silva
authors.forename: M Conceição F
authors.initials: MC
authors.lastname: Oliveira
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D039681:Pyranocoumarins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011714:Pyrans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027821:Rutaceae
chemical_list: D000700:Analgesics; D003374:Coumarins; D010936:Plant Extracts; D039681:Pyranocoumarins; D011714:Pyrans; D005557:Formaldehyde; C516746:seselin; D019342:Acetic Acid