title: Recombinant activated factor seven in acute life-threatening bleeding in neonates: report on three cases and review of literature.
abstract: BACKGROUND
  Acute bleeding of different genesis can be a severe, life-threatening problem in neonatology. Recombinant factor seven (rFVIIa) is known to have unique hemostatic properties in adults and older children.
  
  
  METHODS
  Three cases of acute life-threatening peri- and postnatal hemorrhage were successfully controlled after the application of fFVIIa. All infants were first treated with vitamin K, fresh-frozen plasma and platelet transfusion.
  
  
  CONCLUSIONS
  The cases substantiate other reports that rFVIIa is an effective treatment for acute, refractory and life-threatening bleeding in neonates and premature infants.
authors.affiliation: Department of Neonatology, Children's Hospital of the University of Cologne, Cologne, Germany. ch@kksk.de
authors.forename: C
authors.initials: C
authors.lastname: Hünseler
authors.forename: A
authors.initials: A
authors.lastname: Kribs
authors.forename: F
authors.initials: F
authors.lastname: Eifinger
authors.forename: B
authors.initials: B
authors.lastname: Roth
mesh_terms: D005167:Factor VII / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII