The intestinal microvasculature as a therapeutic target in inflammatory bowel disease.
Chronic inflammation is a complex biologic process which involves immune as well as non-immune cells including the microvasculature and its endothelial lining. Growing evidence suggests that the microvasculature plays an integral role in the pathophysiology of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The microvasculature contributes to chronic inflammation through altered leukocyte recruitment, impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of IBD microvascular biology represent therapeutic targets that are currently undergoing investigation.
Hatoum
Ossama A
OA
Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.
Heidemann
Jan
J
Binion
David G
DG
D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use; D000818:Animals; D002448:Cell Adhesion; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D007422:Intestines / Q000098:blood supply*; D008833:Microcirculation / Q000503:physiopathology*; D018919:Neovascularization, Physiologic
D043925:Angiogenesis Inducing Agents