title: Asian outpatients with schizophrenia: a double-blind randomized comparison of quality of life and clinical outcomes for patients treated with olanzapine or haloperidol.
abstract: To examine the quality of life (QoL) and clinical outcomes for Asian schizophrenic outpatients treated with olanzapine or haloperidol. Patients were randomized to 24-weeks' treatment with either olanzapine (n = 144) or haloperidol (n = 132) in a double-blind, prospective, multi-country study. The QLS and WHO-BREF were assessed for QoL; the PANSS, BPRS and CGI scales for clinical status; the BAS, AIMS and SAS scales for physical dysfunction. Regardless of antipsychotic, QoL improved significantly at 8 weeks and maintained this improvement at 24 weeks. Compared with haloperidol, olanzapine treatment was associated with significantly better QoL in the WHO-BREF physical and social relationship domains, better improvements in extrapyramidal symptoms in BAS and SAS scores, as well as lower incidence of adverse events. Patients taking haloperidol were more likely to be co-prescribed anticholinergics. The comparatively superior side-effect profile and tolerability of olanzapine may have contributed to enhance domain-specific QoL for these Asian outpatients.
authors.affiliation: Department of Psychiatry, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand. rarks@mahidol.ac.th
authors.forename: Ronnachai
authors.initials: R
authors.lastname: Kongsakon
authors.forename: Pureza
authors.initials: P
authors.lastname: Trinidad-Oñate
authors.forename: Haroon Rashid
authors.initials: HR
authors.lastname: Chaudhry
authors.forename: Syed Baqar
authors.initials: SB
authors.lastname: Raza
authors.forename: Cynthia R
authors.initials: CR
authors.lastname: Leynes
authors.forename: Inam-ur-Rehman
authors.initials: IU
authors.lastname: Khan
authors.forename: Hasanah Che
authors.initials: HC
authors.lastname: Ismail
authors.forename: Benjamin
authors.initials: B
authors.lastname: Chan
authors.forename: Joy C
authors.initials: JC
authors.lastname: Ignacio
authors.forename: Sonia C
authors.initials: SC
authors.lastname: Rodriguez
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Lowry
authors.forename: Alan J M
authors.initials: AJ
authors.lastname: Brnabic
authors.forename: Robert
authors.initials: R
authors.lastname: Buenaventura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D044466:Asian People; D001569:Benzodiazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D011788:Quality of Life; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D006220:Haloperidol; D000077152:Olanzapine