title: [Granulosa cells as indicators of oocyte quality].
abstract: Granulosa-cumulus cells are located around the oocyte and may be involved in competence acquisition and in the resumption of oocyte meiosis. We assessed Bax expression in granulosa-cumulus cells and its correlation to in vitro resumption of oocyte meiosis in women presenting PCOS (polycystic ovarian syndrome), as well as the role of the chemokine SDF1-CXCL12 in human preovulatory follicle in the follow-up of granulosa cell survival and embryo quality in IVF.
authors.affiliation: INSERM U-764 - Hôpital Antoine-Béclère, Clamart.
authors.forename: V
authors.initials: V
authors.lastname: Machelon
mesh_terms: D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000502:physiology; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004622:Embryo, Mammalian / Q000502:physiology; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D015870:Gene Expression; D006107:Granulosa Cells / Q000502:physiology*; D006801:Humans; D008540:Meiosis; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D011085:Polycystic Ovary Syndrome; D051028:bcl-2-Associated X Protein / Q000235:genetics
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D006063:Chorionic Gonadotropin; D051028:bcl-2-Associated X Protein