title: Toxoplasmic chorioretinitis and antitumor necrosis factor treatment in rheumatoid arthritis.
abstract: OBJECTIVE
  To present the data supporting the possible relationship of ocular toxoplasmosis to antitumor necrosis factor-alpha (TNF-alpha) therapy in patients with rheumatoid arthritis (RA).
  
  
  METHODS
  A Medline search was performed using the words "toxoplasmosis, anti-TNF-alpha antagonists, chorioretinitis." We report 2 RA patients who developed ocular toxoplasmosis while receiving anti-TNF-alpha therapy.
  
  
  RESULTS
  In addition to our patients with toxoplasmic chorioretinitis, there are 2 published cases of cerebral toxoplasmosis during treatment with anti-TNF-alpha agents.
  
  
  CONCLUSIONS
  The risk of serious toxoplasmic infection during anti-TNF-alpha therapy for RA should be recognized.
authors.affiliation: Service de Rhumatologie, Centre Hospitalier, Cahors, France. slim.lassoued@ch-cahors.fr
authors.forename: Slim
authors.initials: S
authors.lastname: Lassoued
authors.forename: Laurent
authors.initials: L
authors.lastname: Zabraniecki
authors.forename: Frédéric
authors.initials: F
authors.lastname: Marin
authors.forename: Thierry
authors.initials: T
authors.lastname: Billey
mesh_terms: D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000469:parasitology; D002825:Chorioretinitis / Q000469:parasitology; D005260:Female; D006801:Humans; D000069285:Infliximab; D008297:Male; D014122:Toxoplasma; D014126:Toxoplasmosis, Ocular / Q000139:chemically induced*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab