title: trans-2,5-Disubstituted pyrrolidines: Rapid stereocontrolled access from sulfones.
abstract: A direct and versatile route for the reliable synthesis of trans-2,5-disubstituted pyrrolidines from pyroglutamic acid is reported, which can be conducted at scale and without chromatographic purification of key intermediates.
authors.affiliation: The Department of Chemistry, Chemistry Research Laboratory, The University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Moloney
authors.forename: Terry
authors.initials: T
authors.lastname: Panchal
authors.forename: Richard
authors.initials: R
authors.lastname: Pike
mesh_terms: D009942:Organometallic Compounds / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D011759:Pyrrolidines; D013450:Sulfones