title: Accelerated versus classical hepatitis B virus vaccination programs in healthcare workers accelerated vs. classical HBV vaccination.
abstract: BACKGROUND
  The aim of this study was to compare the efficacy of a standard hepatitis B virus vaccination program (day 0-30-60) with an accelerated vaccination program (day 0-10-21) in healthy healthcare workers.
  
  
  METHODS
  Participants were randomly assigned to a classical (group 1, days 0, 30, and 60) or an accelerated vaccination program (group 2, days 0, 10, and 21). The vaccine used was 20 pg recombinant hepatitis B vaccine (recombinant hepatitis B vaccine derived from yeast cells, Engerix B, Smith Cline Beachum). HBV markers were re-examined for the emergence of anti-HBsAg and also to detect the development of a possible acute HBV infection one, two, and three months after the last dose of vaccine. Anti-HBsAg titers >10 mIU/l were accepted as protective.
  
  
  RESULTS
  The seroprotection rates were similar one, two, and three months after the last dose of vaccine in both groups. Anti-HBsAg titers in group 1 were higher than in group 2 two and three months after the last dose of vaccination (p<0.05).
  
  
  CONCLUSIONS
  Our data indicate that the accelerated HBV vaccination program was as effective as the classical vaccination program.
authors.affiliation: Department of Internal Medicine Division of Oncology, Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Mustafa Oktay
authors.initials: MO
authors.lastname: Tarhan
authors.forename: All Ihsan
authors.initials: AI
authors.lastname: Aker
authors.forename: Oguz Resat
authors.initials: OR
authors.lastname: Sipahi
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kardes
authors.forename: Kadir
authors.initials: K
authors.lastname: Biberoglu
mesh_terms: D000328:Adult; D005260:Female; D006282:Health Personnel; D006509:Hepatitis B / Q000517:prevention & control* / Q000821:virology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006515:Hepatitis B virus / Q000378:metabolism*; D006801:Humans; D017589:Immunization Programs; D007115:Immunization Schedule; D016273:Occupational Exposure; D013997:Time Factors; D014611:Vaccination
chemical_list: C075654:Engerix-B; D017325:Hepatitis B Vaccines