TFII-IDelta and TFII-Ibeta: unequal brothers fostering cellular proliferation.
Activation of the immediate-early gene c-fos through MAP kinases is a hallmark of growth factor signaling. In this issue of Molecular Cell, Roy and colleagues (Hakre et al., 2006) show that TFII-I isoforms play differential roles in this process.
Santolin
Lisa
L
Gene Expression, GSF-National Research Center for Environment and Health, Institute for Molecular Immunology, Marchionistrasse 25, D-81377 München, Germany.
Meisterernst
Michael
M
D017398:Alternative Splicing; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D020033:Protein Isoforms; D015398:Signal Transduction; D019473:Transcription Factors, TFII / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
C104259:GTF2I protein, human; D020033:Protein Isoforms; D019473:Transcription Factors, TFII