title: Review article: from 1906 to 2006--a century of major evolution of understanding of gastro-oesophageal reflux disease.
abstract: BACKGROUND
  Our understanding of gastro-oesophageal reflux disease has undergone significant changes over the last century.
  
  
  OBJECTIVE
  To trace the rise in understanding of gastro-oesophageal reflux disease and highlight remaining areas of uncertainty.
  
  
  METHODS
  Literature review.
  
  
  RESULTS
  In 1906, Tileston published his observations on 'peptic ulcer of the oesophagus'. Winkelstein, in 1934, first correlated symptoms of heartburn with acid regurgitation and reflux oesophagitis. In 1946, Allison described hiatus hernia as a causal factor in the development of gastro-oesophageal reflux disease. In 1958, Bernstein and Baker showed a direct relationship between oesophageal acidification and heartburn in patients with gastro-oesophageal reflux disease, irrespective of endoscopic findings, leading to the recognition of non-erosive gastro-oesophageal reflux disease. In the 1980s, continuous recordings of the lower oesophageal sphincter showed that episodes of reflux were related to transient relaxations of lower oesophageal sphincter tone. There is now increasing recognition that gastro-oesophageal reflux disease arises from the interaction of several anatomical and physiological factors. A turning point in the medical treatment of gastro-oesophageal reflux disease came with the introduction of the first proton pump inhibitor, omeprazole, in 1989.
  
  
  CONCLUSIONS
  Future efforts need to identify the multifactorial interactions of gastro-oesophageal junction anatomy and physiology in patients with gastro-oesophageal reflux disease. Increased understanding of the disease will guide development of new therapies.
authors.affiliation: Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia. jdent@mail.rah.sa.gov.au
authors.forename: J
authors.initials: J
authors.lastname: Dent
mesh_terms: D001471:Barrett Esophagus / Q000266:history*; D004867:Equipment Design; D005764:Gastroesophageal Reflux / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans