title: The etiology of hypertension in the metabolic syndrome part four: the systemic perspective--the role of the neuroendocrine and immune systems, and the challenge of integration.
abstract: Insulin resistance can be regarded to be a cause, a consequence, a sustainer or a marker of the wider neuroendocrine dysfunction within which it occurs. In the final part of our series of reviews, we examine the systemic influences which operate within the metabolic syndrome: the endocrine system, the central nervous system and the immune system. We discuss strategies for integrating the array of information that is being gathered, in particular the need for computer simulation. We also advocate the need to move beyond the linear paradigm of 'cause and effect' and use causal networks to think about this system. We also discuss the need to understand the temperospatial organisation of the factors being studied. Finally, we draw together the data, concepts and hypotheses we have reviewed over the course of these four articles.
authors.affiliation: Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, V6T 1Z3, Canada. vijaysha@interchange.ubc.ca
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
authors.forename: John H
authors.initials: JH
authors.lastname: McNeill
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology; D000818:Animals; D006728:Hormones / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology*; D007107:Immune System / Q000503:physiopathology*; D007328:Insulin / Q000502:physiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000276:immunology / Q000503:physiopathology*; D009490:Neurosecretory Systems / Q000503:physiopathology*
chemical_list: D006728:Hormones; D007328:Insulin