title: [Baclofen-associated encephalopathy in a hemodialysis patient with hiccups].
abstract: Baclofen is a centrally acting gamma-ammino butyric acid agonist that is used like muscular relaxant in disorders with spasticity and intractable hiccups. Although encouraging and safe results were provided 5 mg/day in hemodialysis patients, his pharmacokinetic and pharmacodinamic properties are not well known in end stage renal disease. We present here the case of a hemodialysis patient with intractable hiccups who developed baclofen-associated encephalopathy with this recommended dose.
authors.affiliation: Servicio de Nefrología y Trasplante Renal, Hospital Clinic, Barcelona. lfquintana@clinic.ub.es
authors.forename: L F
authors.initials: LF
authors.lastname: Quintana
authors.forename: A
authors.initials: A
authors.lastname: Lladó
authors.forename: M
authors.initials: M
authors.lastname: Butjosa
authors.forename: J
authors.initials: J
authors.lastname: Santamaría
authors.forename: A
authors.initials: A
authors.lastname: Torras
authors.forename: E
authors.initials: E
authors.lastname: Poch
mesh_terms: D000368:Aged; D001418:Baclofen / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced*; D006606:Hiccup / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D006435:Renal Dialysis
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen