Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease.
OBJECTIVE
The purpose of this study was to investigate the association between plasma pyridoxal 5'-phosphate (PLP) status and lipid profiles and to estimate the relation to the risk of coronary artery disease (CAD).


METHODS
Patients who were identified by cardiac catheterization as having > or =70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group (n = 516) was comprised of healthy individuals with normal blood biochemical values. Plasma PLP, homocysteine, high-sensitivity C-reactive protein, lipid profiles (total cholesterol, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, and triacylglycerol) were determined.


RESULTS
Subjects with a plasma PLP level <30 nmol/L exhibited a significantly increased risk of CAD compared with subjects with a plasma PLP level > or =30 nmol/L (odds ratio, 1.85; 95% confidence interval, 1.16-2.95) after adjusting for homocysteine and high-sensitivity C-reactive protein. The association between PLP and the risk of CAD remained significant after each lipid profile was additionally adjusted. In addition, the combined presence of low PLP level and an abnormal lipid level increased the risk of CAD to an even greater degree.


CONCLUSIONS
A borderline vitamin B6 deficiency (plasma PLP concentration <30 nmol/L) is strongly associated with the risk of CAD. The combined presence of low PLP and abnormal lipid levels increased the risk of CAD even further.
Lin
Ping-Ting
PT
School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
Cheng
Chien-Hsiang
CH
Liaw
Yung-Po
YP
Lee
Bor-Jen
BJ
Lee
Tsung-Wen
TW
Huang
Yi-Chia
YC
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000097:blood*; D012307:Risk Factors; D026681:Vitamin B 6 Deficiency / Q000097:blood* / Q000150:complications; D014803:Vitamin B Complex / Q000097:blood*
D008055:Lipids; D006710:Homocysteine; D014803:Vitamin B Complex; D011732:Pyridoxal Phosphate; D002097:C-Reactive Protein