title: COMT Val108/158Met gene variant, birth weight, and conduct disorder in children with ADHD.
abstract: OBJECTIVE
  In a recent study, Thapar and colleagues reported that COMT "gene variant and birth weight predict early-onset antisocial behavior in children" with attention-deficit/hyperactivity disorder. We have attempted to replicate these findings in a group of ADHD children using a similar research design.
  
  
  METHODS
  Children (n=191) between 6 and 12 years of age who were diagnosed with ADHD were included in the study. Conduct disorder was diagnosed according to DSM-IV criteria based on clinical evaluation and a structured interview (Diagnostic Interview Schedule for Children-IV). The mother's report on the child's birth weight was used in the analysis. Logistic regression analysis, with genotype and birth weight as independent variables and DSM-IV conduct disorder as the dependent variable, was conducted.
  
  
  RESULTS
  No significant main effects of genotype and birth weight or interaction effects on conduct disorder were observed.
  
  
  CONCLUSIONS
  In this sample of children diagnosed with ADHD, we find no association between the COMT ValMet gene variant, birth weight, and conduct disorder. Further investigations are required before using birth weight and COMT genotype as predictors of conduct disorder in children with attention-deficit/hyperactivity disorder, especially given the societal and legal ramifications of conduct disorder.
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Sarojini M
authors.initials: SM
authors.lastname: Sengupta
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Natalie
authors.initials: N
authors.lastname: Grizenko
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Norbert
authors.initials: N
authors.lastname: Schmitz
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: George
authors.initials: G
authors.lastname: Schwartz
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Leila
authors.initials: L
authors.lastname: Ben Amor
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Johanne
authors.initials: J
authors.lastname: Bellingham
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Rosherrie
authors.initials: R
authors.lastname: DE Guzman
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Anna
authors.initials: A
authors.lastname: Polotskaia
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Marina
authors.initials: M
authors.lastname: Ter Stepanian
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.
authors.forename: Geeta
authors.initials: G
authors.lastname: Thakur
authors.affiliation: Drs. Sengupta, Ben Amor, and Joober are with the Department of Human Genetics, Drs. Grizenko and Joober and Mr. Schwartz are with the Department of Psychiatry, Dr. Joober and Ms. Thakur are with the Department of Neurology and Neurosurgery, McGill University; and Drs. Sengupta, Schmitz, and Joober, Mr. Schwartz, Ms. Bellingham, Ms. de Guzman, Ms. Polotskaia, and Ms. Ter Stepanian are with Douglas Hospital Research Centre, Montreal, Quebec, Canada.. Electronic address: ridha.joober@douglas.mcgill.ca.
authors.forename: Ridha
authors.initials: R
authors.lastname: Joober
mesh_terms: D001724:Birth Weight / Q000235:genetics* / Q000502:physiology; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D002648:Child; D019955:Conduct Disorder / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male
chemical_list: D002394:Catechol O-Methyltransferase