title: The validity of in vitro ultrasonographic grading of osteoarthritic femoral condylar cartilage--a comparison with histologic grading.
abstract: OBJECTIVE
  To establish an ultrasonographic grading for semi-quantitative evaluation of the femoral condylar cartilage of knee osteoarthritis (OA), in vitro, and compare the ultrasonographic grading with the histologic grading.
  
  
  METHODS
  Thirty-four patients going to receive total knee arthroplasty because of OA of the knee were recruited. Specimens of the distal medial and lateral femoral condyles were taken during the operation. The anterior and middle areas of the articular cartilage in each specimen were graded by in vitro ultrasonography (US) examination and histologic evaluation. The correlation between the US and histologic findings was analyzed.
  
  
  RESULTS
  Sixty-seven specimens were collected. Both US and histologic changes were graded from I to IV. The correlation between the grading of US and histology was good in both anterior and middle areas (Rho=0.78, 0.89, P<0.001). The correlation between US grading over anterior area and histology grading over middle area was moderate (Rho=0.70, P<0.001).
  
  
  CONCLUSIONS
  The moderate correlation between in vitro US and histology might permit quantitative in vivo assessment of cartilage.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Tsai
authors.forename: C-L
authors.initials: CL
authors.lastname: Lee
authors.forename: C-Y
authors.initials: CY
authors.lastname: Chai
authors.forename: C-H
authors.initials: CH
authors.lastname: Chen
authors.forename: J-Y
authors.initials: JY
authors.lastname: Su
authors.forename: H-T
authors.initials: HT
authors.lastname: Huang
authors.forename: M-H
authors.initials: MH
authors.lastname: Huang
mesh_terms: D002358:Cartilage, Articular / Q000000981:diagnostic imaging* / Q000473:pathology; D005269:Femur; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014463:Ultrasonography