title: The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trials.
abstract: OBJECTIVE
  To test (a) whether and when bone augmentation procedures are necessary and (b) which is the most effective augmentation technique for specific clinical indications. Trials were divided into 3 categories: (1) major vertical or horizontal bone augmentation (or both); (2) implants placed in extraction sockets; (3) fenestrated implants.
  
  
  METHODS
  An exhaustive search was conducted for all randomized controlled clinical trials (RCTs) comparing different techniques and materials for augmenting bone for implant treatment reporting the outcome of implant therapy at least to abutment connection. No language restriction was applied. The last electronic search was conducted on October 1, 2005.
  
  
  RESULTS
  Thirteen RCTs of 30 potentially eligible trials reporting the outcome of 332 patients were suitable for inclusion. Six trials evaluated techniques for vertical and/or horizontal bone augmentation. Four trials evaluated techniques of bone grafting for implants placed in extraction sockets, and 3 trials evaluated techniques to treat fenestrated implants.
  
  
  CONCLUSIONS
  Major bone grafting procedures of extremely resorbed mandibles may not be justified. Bone substitutes may replace autogenous bone for sinus lift procedures of extremely atrophic sinuses. Both guided bone regeneration procedures and distraction osteogenesis can be used to augment bone vertically, but it is unclear which is the most efficient. It is unclear whether augmentation procedures are needed at immediate single implants placed in fresh extraction sockets; however, sites treated with barrier + Bio-Oss showed a higher position of the gingival margin than sites treated with barriers alone. More bone was regenerated around fenestrated implants with nonresorbable barriers than without barriers; however, it remains unclear whether such bone is of benefit to the patient. Bone morphogenetic proteins may enhance bone formation around implants grafted with Bio-Oss, but there was no reliable evidence supporting the efficacy of other active agents, such as platelet-rich plasma, in conjunction with implant treatment.
authors.affiliation: Oral and Maxillofacial Surgery, Cochrane Oral Health Group, School of Dentistry, The University of Manchester, United Kingdom. espositomarco@hotmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Esposito
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Grusovin
authors.forename: Paul
authors.initials: P
authors.lastname: Coulthard
authors.forename: Helen V
authors.initials: HV
authors.lastname: Worthington
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D019485:Bone Morphogenetic Proteins; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation; D002130:Calcium Phosphates; D003758:Dental Implantation, Endosseous; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery; D008903:Minerals; D019857:Osteogenesis, Distraction; D053657:Platelet-Rich Plasma; D016032:Randomized Controlled Trials as Topic; D020390:Tooth Socket; D014716:Vertical Dimension
chemical_list: C077540:Bio-Oss; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D002130:Calcium Phosphates; D008903:Minerals; C485817:beta-tricalcium phosphate