Insights into recombination from population genetic variation.
Patterns of genetic variation in natural populations are shaped by, and hence carry valuable information about, the underlying recombination process. In the past five years, the increasing availability of large-scale population genetic data on dense sets of markers, coupled with advances in statistical methods for extracting information from these data, have led to several important advances in our understanding of the recombination process in humans. These advances include the identification of large numbers of 'hotspots', where recombination appears to take place considerably more frequently than in the surrounding sequence, and the identification of DNA sequence motifs that are associated with the locations of these hotspots.
Hellenthal
Garrett
G
Department of Statistics, University of Washington, Seattle, WA 98195, USA.
Stephens
Matthew
M
D000818:Animals; D003434:Crossing Over, Genetic; D030541:Databases, Genetic; D019143:Evolution, Molecular; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D011153:Population / Q000235:genetics*; D011995:Recombination, Genetic