title: Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima.
abstract: Two new cyclic heptapeptides, integerrimides A and B, have been isolated from the latex of Jatropha integerrima. Their structures were elucidated by using extensive 1D and 2D NMR, MS, and chemical degradation. At 50 microM both peptides 1 and 2 significantly inhibited neurite outgrowth in neuronal cell culture. They also partially inhibited proliferation of human IPC-298 melanoma cells as well as migration of human Capan II pancreatic carcinoma cells, but were inactive in HSV-1, antifungal, and antimalarial assays.
authors.affiliation: Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
authors.forename: Wantana
authors.initials: W
authors.lastname: Mongkolvisut
authors.forename: Somyote
authors.initials: S
authors.lastname: Sutthivaiyakit
authors.forename: Heiko
authors.initials: H
authors.lastname: Leutbecher
authors.forename: Sabine
authors.initials: S
authors.lastname: Mika
authors.forename: Iris
authors.initials: I
authors.lastname: Klaiber
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Möller
authors.forename: Harald
authors.initials: H
authors.lastname: Rösner
authors.forename: Uwe
authors.initials: U
authors.lastname: Beifuss
authors.forename: Jürgen
authors.initials: J
authors.lastname: Conrad
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002645:Chickens; D004354:Drug Screening Assays, Antitumor; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D031286:Jatropha / Q000737:chemistry*; D007840:Latex / Q000737:chemistry; D015394:Molecular Structure; D016501:Neurites / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects; D013785:Thailand
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007840:Latex; D010456:Peptides, Cyclic; C515180:integerrimide A; C515181:integerrimide B