title: Clinical trials and oral care R&D.
abstract: The introduction of hydrogen peroxide whitening strips in 2000 has contributed to new paradigms for treatment and expanded interest in tooth whitening. Clinical trials played a prominent role in the whitening strip research and development process. Four case studies from the whitening strip development program are used to review the fundamentals of clinical trials design, conduct, analysis, and interpretation as part of new product development in oral care.
authors.affiliation: The Procter & Gamble Company, Mason, OH, USA. erlach.rw@pg.com
authors.forename: Robert W
authors.initials: RW
authors.lastname: Gerlach
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D018865:Dental Research / Q000379:methods*; D006801:Humans; D014073:Tooth Bleaching / Q000009:adverse effects / Q000379:methods*