Regio- and diastereocontrolled C-H insertion of chiral gamma- and delta-lactam diazoacetates. Application to the asymmetric synthesis of (8S,8aS)-8-hydroxyindolizidine.
gamma- and delta-Lactam diazoacetates undergo efficient intramolecular C-H insertion catalyzed by Rh2(MPPIM)4 with excellent regioselectivity and cis-diastereoselectivity to provide synthetically useful bicyclic lactam lactones.
Fan
Gao-Jun
GJ
Department of Chemistry and Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.
Wang
Zhongyi
Z
Wee
Andrew G H
AG