title: Spirocyclic helical compounds as binding agents for bulged RNA, including HIV-2 TAR.
abstract: Based on fluorescence binding studies and 1D 1H NMR studies, designed synthetic analogues of NCSi-gb bind specifically with two-base bulged RNA, including HIV-2 TAR RNA, making them potential lead compounds for antiviral drug development.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Xiao
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Lin
authors.forename: Graham B
authors.initials: GB
authors.lastname: Jones
authors.forename: Irving H
authors.initials: IH
authors.lastname: Goldberg
mesh_terms: D005643:Fucose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D016325:HIV Long Terminal Repeat; D015498:HIV-2 / Q000235:genetics*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D012367:RNA, Viral / Q000737:chemistry / Q000378:metabolism*; D013141:Spiro Compounds / Q000737:chemistry* / Q000378:metabolism
chemical_list: C520353:NCSi-gb compound; D012367:RNA, Viral; D013141:Spiro Compounds; D005643:Fucose