title: Bisphosphonates and oral pathology II. Osteonecrosis of the jaws: review of the literature before 2005.
abstract: Bisphosphonates are bone-turnover modulating drugs which are used in the management of a number of bone diseases ranging from osteoporosis to neoplasic pathology-associated osteolysis. In the last years a number of cases of osteonecrosis of the jaws associated with these drugs have been reported. In this review we analyze the cases published in the literature indexed from 2003 to December 2005. During this period 246 cases were reported, being more frequently associated with women in the sixth decade of life. More frequently associated bisphosphonates were the nitrogenated bisphosphonates (pamidronate, zolendronic acid) and the most common oral antecedent was a dental extraction. Nevertheless more than 25% of the cases were spontaneous. The most frequent site was the mandible and most of the cases presented clinical evidence of bone exposure and pain. Different treatments have been proposed with different antibiotic therapies with or without surgery, showing in general terms an uncertain prognosis with low healing rates.
authors.affiliation: Medicina Bucal, Departamento de Estomatología, Unidad de Patología Oral y Maxilofacial, Servicio Clínica Odontológica, Universidad del País Vasco EHU.
authors.forename: Ruth
authors.initials: R
authors.lastname: Estefanía Fresco
authors.forename: Ruth
authors.initials: R
authors.lastname: Ponte Fernández
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Aguirre Urizar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*
chemical_list: D004164:Diphosphonates