[Effect of glaucocalyxin A on level of Th1/Th2 type cytokines in mice].
OBJECTIVE
To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.


METHODS
By using flow cytometer with CBA software to detect Th1/Th2 type cytokines.


RESULTS
GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those of from Th2 were displayed. However, GLA could produce inhibition on IL-2, IFN-gamma and TNF-alpha and acceleration on IL-4 and IL-5.


CONCLUSIONS
Immunosuppressive effect of GLA is related to the influence the level of Th1/Th2 type cytokines.
Chen
Zi-jun
ZJ
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine. zjchen21@yahoo.com.cn
Li
Yun-sen
YS
Zhou
Ji-yan
JY
Wang
Zheng-tao
ZT
D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D037602:Isodon / Q000737:chemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal / Q000737:chemistry; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D015848:Interleukin-5; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; C055124:glaucocalyxin A; D007371:Interferon-gamma