title: [Genetic advances in hydatidiform mole].
abstract: Hydatidiform mole is the most common gestational trophoblastic disease and is characterized by gross trophoblastic hyperplasia resulting from abnormal fertilization of the oocyte. It is of great interest to researchers because of its propensity for local invasion and spreading. Using cytogenetic and molecular genetic techniques researchers have performed various studies on hydatidiform mole. There are advances in the understanding of karyotype, DNA ploidy, fertilization types, expression of imprinted genes, the differences between genetic classification and pathologic classification, and the correlation to its invasion and spreading.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083,China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Shu-ying
authors.initials: SY
authors.lastname: Wu
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Zhang
mesh_terms: D005260:Female; D018392:Genomic Imprinting; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000473:pathology; D007621:Karyotyping; D011003:Ploidies; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology