title: Total body propofol clearance (TBPC) after living-donor liver transplantation (LDLT) surgery is decreased in patients with a long warm ischemic time.
abstract: Metabolic capacity after liver transplant surgery may be affected by the graft size and by hepatic injury during the surgery. This study was carried out to investigate the postoperative total body propofol clearance (TBPC) in living-donor liver transplantation (LDLT) patients and to investigate the major factors that contribute to decreased postoperative TBPC in LDLT patients. Fourteen patients scheduled for LDLT were included in this study. Propofol was administered at a rate of 2.0 mg.kg(-1).h(-1) as a sedative in the intensive care unit (ICU) setting. To calculate TBPC, propofol arterial blood concentration was measured by HPLC. Five variables were selected as factors affecting postoperative TBPC; bleeding volume (BLD), warm ischemic time (WIT), cold ischemic time (CIT), graft weight/standard liver volume ratio (GW/SLV), and portal blood flow after surgery (PBF). After factor analysis of six variables, including TBPC, varimax rotation was carried out, and this yielded three interpretable factors that accounted for 75.5% of the total variance in the data set. TBPC, WIT, CIT, and BLD were loaded on the first factor, PBF on the second factor, and GW/SLV on the third factor. The adjusted correlation coefficient between TBPC and WIT showed the highest value (r = -0.61) in the first factor. The LDLT patients were divided into two groups according to WIT; group A (WIT > 100 min) and group B (WIT < 100 min). Mean TBPC values in group A and group B were 14.6 +/- 2.1 and 28.5 +/- 4.1 ml.kg(-1).min(-1), respectively (P < 0.0001). These data suggest that LDLT patients with a long WIT have a risk of deteriorated drug metabolism.
authors.affiliation: Department of Anesthesiology and Intensive Care, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, 371-8511, Japan.
authors.forename: Wael S
authors.initials: WS
authors.lastname: Al-Jahdari
authors.forename: Fumio
authors.initials: F
authors.lastname: Kunimoto
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
authors.forename: Koujirou
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koyama
authors.forename: Ryuya
authors.initials: R
authors.lastname: Horiuchi
authors.forename: Fumio
authors.initials: F
authors.lastname: Goto
mesh_terms: D000293:Adolescent; D000328:Adult; D018686:Anesthetics, Intravenous / Q000097:blood / Q000493:pharmacokinetics*; D002648:Child; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011182:Postoperative Care; D015742:Propofol / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors; D052096:Warm Ischemia / Q000009:adverse effects*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol