mPar6 alpha controls neuronal migration.
We review studies on the polarity of developing cerebellar granule, showing that the centrosome localizes to the pole of the neuron that extrudes the nascent axon, and the Rho GTPase Cdc42 (cell division cycle 42) activates the mPar6alpha/Par3 (Par for partitioning defective) complex to coordinate actin dynamics in the growth cone. Subsequently, mPar6alpha signaling controls the migration of immature granule neurons down the Bergmann glial fibers into the internal granule cell layer in which they establish synaptic connections.
Solecki
David J
DJ
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA.
Govek
Eve-Ellen
EE
Hatten
Mary E
ME
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002531:Cerebellum / Q000166:cytology / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology / Q000502:physiology*; D020033:Protein Isoforms; D011506:Proteins / Q000502:physiology; D013569:Synapses / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D008565:Membrane Proteins; C509689:PARD3 protein, human; D020033:Protein Isoforms; D011506:Proteins