title: [Clinicopathologic study of cryptogenic organizing pneumonia].
abstract: OBJECTIVE
  To study the clinicopathologic features and differential diagnosis of cryptogenic organizing pneumonia (COP).
  
  
  METHODS
  The clinical, radiologic and pathologic features of 11 patients with COP confirmed by open or video-assisted thoracoscopic (VATS) lung biopsy were analyzed. Treatment information and follow-up data were also obtained.
  
  
  RESULTS
  COP usually affected female patients over 40 years of age. Clinical presentations included cough, sputum and exertional dyspnea. High-resolution computerized tomography showed scattered speckled, patchy and trabecular shadows over both lung fields. Honeycomb changes were not found. Histologically, polypoid growths of granulation tissue were noted within respiratory bronchioles, small airways and alveolar spaces. These lesions had a patchy and peribronchiolar distribution and were uniform in appearance. The overall response rate to glucocorticoid was 81.8% (P < 0.01). The duration of follow up ranged from 6 to 134 months. Apart from one patient who developed aggravation of symptoms, the disease pursued a relatively stable clinical course.
  
  
  CONCLUSIONS
  In general, COP responds well to glucocorticoid therapy. Open or VATS lung biopsy is important for arriving at a definitive diagnosis, especially for those cases presenting with atypical clinical and radiographic manifestations. Multiple biopsies with larger samples are preferred in order to avoid misdiagnosis.
authors.affiliation: Department of Pathology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China. yixhxf@yahoo.com.cn
authors.forename: Xiang-hua
authors.initials: XH
authors.lastname: Yi
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.forename: Jing-yun
authors.initials: JY
authors.lastname: Shi
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Chen
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Jin-ming
authors.initials: JM
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D018549:Cryptogenic Organizing Pneumonia / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013906:Thoracoscopy / Q000379:methods; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D011241:Prednisone; D008775:Methylprednisolone