Topical delivery of silver nanoparticles promotes wound healing.
Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.
Tian
Jun
J
Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
Wong
Kenneth K Y
KK
Ho
Chi-Ming
CM
Lok
Chun-Nam
CN
Yu
Wing-Yiu
WY
Che
Chi-Ming
CM
Chiu
Jen-Fu
JF
Tam
Paul K H
PK
D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016207:Cytokines / Q000378:metabolism; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D012834:Silver / Q000008:administration & dosage*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000473:pathology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D016207:Cytokines; D012834:Silver