title: Classification of canine urinary bladder urothelial tumours based on the World Health Organization/International Society of Urological Pathology consensus classification.
abstract: One hundred canine urinary bladder urothelial (transitional cell) tumours, including roughly equal numbers of benign and malignant forms, were retrospectively categorized in accordance with the newly described human consensus classification of the World Health Organization/International Society of Urological Pathology (WHO/ISUP). The tumours were reviewed and classified by three veterinary pathologists from Michigan State University and two human pathologists from the Armed Forces Institute of Pathology (AFIP). The current human WHO/ISUP classification system was considered to be readily applicable to the dog. Canine tumours, however, differed from human tumours in that the great majority showed extensive glandular differentiation (or metaplasia) and hyperplastic lesions tended to be more florid than those seen in human beings. The various diagnoses and grades assigned to the tumours were highly consistent between all reviewing pathologists. This paper presents the salient features of the new WHO and ISUP consensus classification and provides illustrations of the various tumour types that were directly applicable to the dog.
authors.affiliation: MPI Research, Mattawan, Michigan 49071, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Patrick
authors.forename: S D
authors.initials: SD
authors.lastname: Fitzgerald
authors.forename: I A
authors.initials: IA
authors.lastname: Sesterhenn
authors.forename: C J
authors.initials: CJ
authors.lastname: Davis
authors.forename: M
authors.initials: M
authors.lastname: Kiupel
mesh_terms: D000818:Animals; D032921:Consensus; D004283:Dog Diseases / Q000145:classification* / Q000473:pathology; D004285:Dogs; D006801:Humans; D009367:Neoplasm Staging; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000145:classification* / Q000473:pathology / Q000662:veterinary*; D019459:Urothelium / Q000473:pathology*; D014944:World Health Organization