title: Role of macrophage metalloelastase in gut inflammation.
abstract: Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases.
authors.affiliation: Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK. s.pender@soton.ac.uk
authors.forename: Sylvia L F
authors.initials: SL
authors.lastname: Pender
authors.forename: C K F
authors.initials: CK
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Di Sabatino
authors.forename: A D I
authors.initials: AD
authors.lastname: Sabatino
authors.forename: T T
authors.initials: TT
authors.lastname: MacDonald
authors.forename: M G
authors.initials: MG
authors.lastname: Buckley
mesh_terms: D003093:Colitis, Ulcerative / Q000201:enzymology / Q000503:physiopathology; D003424:Crohn Disease / Q000201:enzymology / Q000503:physiopathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000201:enzymology / Q000503:physiopathology*; D053508:Matrix Metalloproteinase 12; D008666:Metalloendopeptidases / Q000502:physiology*
chemical_list: D008666:Metalloendopeptidases; C507122:MMP12 protein, human; D053508:Matrix Metalloproteinase 12