title: Endogenous hydrogen sulfide and the cardiovascular system-what's the smell all about?
abstract: OBJECTIVE
  Hydrogen Sulfide has been found to be produced endogenously in amounts that cause vasodilatation. The purpose of this review is to outline the effects of hydrogen sulfide as a gasotransmitter.
  
  
  METHODS
  This article is a summary of work done in Dr. Rui Wang's laboratory and a comprehensive review of H2S on the Pub-Med website.
  
  
  RESULTS
  One of the specific cellular targets of hydrogen sulfide is the K(ATP) channel protein which produces vasodilatation. The other gasotransmitters like NO (nitric oxide) interact with hydrogen sulfide in complex ways. This action could be important in hypertension and other vascular diseases.
  
  
  CONCLUSIONS
  Gasotransmitter research is relevant to the pathophysiology of a number of cardiovascular disease processes.
authors.affiliation: Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5. jpearson2112@yahoo.ca
authors.forename: R James
authors.initials: RJ
authors.lastname: Pearson
authors.forename: Thomas
authors.initials: T
authors.lastname: Wilson
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology*; D002319:Cardiovascular System / Q000503:physiopathology; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects
chemical_list: D015221:Potassium Channels; D009569:Nitric Oxide; D006862:Hydrogen Sulfide