title: Basic mechanisms responsible for osteolytic and osteoblastic bone metastases.
abstract: Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.
authors.affiliation: Department of Medicine, University of Virginia, Charlottesville, Virginia 22903, USA. tag4n@virginia.edu
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Guise
authors.forename: Khalid S
authors.initials: KS
authors.lastname: Mohammad
authors.forename: Gregory
authors.initials: G
authors.lastname: Clines
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Stebbins
authors.forename: Darren H
authors.initials: DH
authors.lastname: Wong
authors.forename: Linda S
authors.initials: LS
authors.lastname: Higgins
authors.forename: Robert
authors.initials: R
authors.lastname: Vessella
authors.forename: Eva
authors.initials: E
authors.lastname: Corey
authors.forename: Susan
authors.initials: S
authors.lastname: Padalecki
authors.forename: Larry
authors.initials: L
authors.lastname: Suva
authors.forename: John M
authors.initials: JM
authors.lastname: Chirgwin
mesh_terms: D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000473:pathology*; D010006:Osteoblasts / Q000378:metabolism / Q000473:pathology*; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology*; D010014:Osteolysis / Q000378:metabolism / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology