Carnosol, a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells.
Carnosol, a major component of Rosmarinus officinalis, is a phenolic diterpene that has potent antioxidant and anti-inflammatory activities. In this study, we investigated the protective effects of carnosol on rotenone-induced neurotoxicity in cultured dopaminergic cells. Results showed that cell viability was significantly improved with carnosol through downregulation of caspase-3. Furthermore, carnosol significantly increased the tyrosine hydroxylase, Nurr1, and extracellular signal-regulated kinase 1/2. These results suggest that carnosol may have potential as a possible compound for the development of new agents to treat Parkinson's disease.
Kim
Sung-Jun
SJ
Department of Biotechnology, Research Center for Proteineous Materials, Chosun University, Gwangju, Republic of Korea.
Kim
Jae-Sung
JS
Cho
Hong-Suk
HS
Lee
Hyo Jung
HJ
Kim
Sang Yong
SY
Kim
Seung
S
Lee
Sook-Young
SY
Chun
Hong Sung
HS
D045784:Abietanes / Q000494:pharmacology*; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D053148:Caspase 3 / Q000096:biosynthesis; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism*; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000502:physiology; D048052:Mitogen-Activated Protein Kinase 3 / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010616:Phenanthrenes / Q000494:pharmacology*; D027542:Rosmarinus / Q000737:chemistry*; D012402:Rotenone; D013378:Substantia Nigra / Q000166:cytology*; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis; D048490:raf Kinases / Q000502:physiology
D045784:Abietanes; D000978:Antiparkinson Agents; D018696:Neuroprotective Agents; D010616:Phenanthrenes; D012402:Rotenone; C068623:carnosol; D014446:Tyrosine 3-Monooxygenase; D048490:raf Kinases; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D053148:Caspase 3; D004298:Dopamine