Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland.
OBJECTIVE
To determine the incidence of severe hyperbilirubinaemia in the newborn, and to identify associated clinical and demographic variables, and short-term outcomes.


METHODS
Prospective, population-based study.


METHODS
UK and Republic of Ireland, between 1 May 2003 and 31 May 2005.


METHODS
Infants in the first month of life with severe hyperbilirubinaemia (maximum unconjugated serum bilirubin >/=510 micromol/l).


RESULTS
108 infants met the case definition, 106 from the UK and 2 from the Republic of Ireland. The UK incidence of severe hyperbilirubinaemia was 7.1/100 000 live births (95% CI 5.8 to 8.6). Only 20 cases presented in hospital; 88 were admitted with severe jaundice. 64 (60.4%) cases were male, and 56 (51.8%) were of ethnic minority origin. 87 (80.5%) cases were exclusively breast fed. Co-morbidity included haemolysis, dehydration, infection and bruising. 14 infants showed evidence of bilirubin encephalopathy, of whom 3 died. The UK incidence of bilirubin encephalopathy was 0.9/100 000 live births (95% CI 0.46 to 1.5).


CONCLUSIONS
This is the first large, prospective, population-based study of the incidence of severe hyperbilirubinaemia in the newborn. The clinical and demographic associations, and short-term outcomes identified, are the same as those reported recently in North America and Europe.
Manning
Donal
D
Donal Manning, Department of Paediatrics, Arrowe Park Hospital, Wirral, Merseyside CH49 5PE, UK. donal.manning@whnt.nhs.uk
Todd
Peter
P
Maxwell
Melanie
M
Jane Platt
Mary
M
D001663:Bilirubin / Q000097:blood; D001803:Blood Transfusion / Q000379:methods; D005260:Female; D006760:Hospitalization; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000453:epidemiology* / Q000628:therapy; D015994:Incidence; D007231:Infant, Newborn; D007494:Ireland / Q000453:epidemiology; D007567:Jaundice, Neonatal / Q000097:blood / Q000453:epidemiology / Q000628:therapy; D007647:Kernicterus / Q000097:blood / Q000453:epidemiology / Q000628:therapy; D008297:Male; D011159:Population Surveillance / Q000379:methods; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D006113:United Kingdom / Q000453:epidemiology
D001663:Bilirubin