title: Is high-grade prostatic intraepithelial neoplasia on needle biopsy different in an Asian population: a clinicopathologic study performed in Singapore.
abstract: OBJECTIVE
  To evaluate the incidence, pathologic findings, and follow-up of high-grade prostatic intraepithelial neoplasia (HGPIN) in a series of prostate core biopsies from Singaporean men.
  
  
  METHODS
  We studied isolated HGPIN diagnosed on prostate core biopsies and the incidence of cancer discovered in men who had undergone repeat biopsies from 1999 to 2003 at the Department of Pathology, Singapore General Hospital.
  
  
  RESULTS
  Of 1219 men undergoing prostate needle biopsy, 56 (4.6%) had isolated HGPIN. Most cases affected a single prostate core (44 cases, 78.6%). Twenty-nine men (51.8%) underwent repeat biopsies. Cancer was discovered in 7 (24.1%) of the 29 men within two repeat biopsies.
  
  
  CONCLUSIONS
  The incidence of isolated HGPIN on prostate needle core biopsies in Asian men, as well as the likelihood of subsequent cancer detection, are comparable to the rates reported for Western populations. The relatively low yield of cancer detection on repeat biopsy supports the need to re-evaluate recommendations for rebiopsy strategies.
authors.affiliation: Department of Pathology, Singapore General Hospital, Singapore, Singapore.
authors.forename: Puay Hoon
authors.initials: PH
authors.lastname: Tan
authors.forename: Hong Wui
authors.initials: HW
authors.lastname: Tan
authors.forename: Yen
authors.initials: Y
authors.lastname: Tan
authors.forename: Chay Ngee
authors.initials: CN
authors.lastname: Lim
authors.forename: Christopher
authors.initials: C
authors.lastname: Cheng
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Epstein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D019048:Prostatic Intraepithelial Neoplasia / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology* / Q000601:surgery; D012086:Reoperation; D012189:Retrospective Studies; D012846:Singapore