title: Synthesis and surface activity of diether-linked phosphoglycerols: potential applications for exogenous lung surfactants.
abstract: The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs were measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants.
authors.affiliation: Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Notter
authors.forename: Zhongyi
authors.initials: Z
authors.lastname: Wang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Wang
authors.forename: Jason A
authors.initials: JA
authors.lastname: Davy
authors.forename: Adrian L
authors.initials: AL
authors.lastname: Schwan
mesh_terms: D005994:Glycerophosphates / Q000138:chemical synthesis* / Q000737:chemistry; D011663:Pulmonary Surfactants / Q000138:chemical synthesis* / Q000737:chemistry; D013500:Surface Tension; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005994:Glycerophosphates; D011663:Pulmonary Surfactants; D013501:Surface-Active Agents