title: Pulse pressure and inflammatory process in atherosclerosis.
abstract: Recent studies have reported positive associations between pulse pressure (PP) and markers of inflammation. These studies are intriguing because they suggest that elevations in PP could induce an inflammatory state and thereby increase the risk of inflammation- related diseases such as atherosclerotic cardiovascular disease. In the present chapter, we review potential mechanisms by which an elevated PP could increase inflammation. We also review human-based studies that have investigated the association between PP and inflammatory biomarkers such as C-reactive protein. The majority of studies support a positive association between PP and inflammatory markers. However, it remains unclear whether the association is truly causal and whether it has relevance in terms of predicting cardiovascular diseases.
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Ga. , USA.
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Abramson
authors.forename: Viola
authors.initials: V
authors.lastname: Vaccarino
mesh_terms: D050197:Atherosclerosis / Q000097:blood* / Q000503:physiopathology*; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D002986:Clinical Trials as Topic; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D013314:Stress, Mechanical
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein