title: A worldwide survey of haplotype variation and linkage disequilibrium in the human genome.
abstract: Recent genomic surveys have produced high-resolution haplotype information, but only in a small number of human populations. We report haplotype structure across 12 Mb of DNA sequence in 927 individuals representing 52 populations. The geographic distribution of haplotypes reflects human history, with a loss of haplotype diversity as distance increases from Africa. Although the extent of linkage disequilibrium (LD) varies markedly across populations, considerable sharing of haplotype structure exists, and inferred recombination hotspot locations generally match across groups. The four samples in the International HapMap Project contain the majority of common haplotypes found in most populations: averaging across populations, 83% of common 20-kb haplotypes in a population are also common in the most similar HapMap sample. Consequently, although the portability of tag SNPs based on the HapMap is reduced in low-LD Africans, the HapMap will be helpful for the design of genome-wide association mapping studies in nearly all human populations.
authors.affiliation: Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.
authors.forename: Donald F
authors.initials: DF
authors.lastname: Conrad
authors.forename: Mattias
authors.initials: M
authors.lastname: Jakobsson
authors.forename: Graham
authors.initials: G
authors.lastname: Coop
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Wen
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Wall
authors.forename: Noah A
authors.initials: NA
authors.lastname: Rosenberg
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Pritchard
mesh_terms: D002874:Chromosome Mapping; D003625:Data Collection / Q000379:methods*; D014644:Genetic Variation; D005828:Genetics, Population; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D016324:Sequence Tagged Sites