The Baylis-Hillman approach to quinoline derivatives.
Baylis-Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed.
Familoni
Oluwole B
OB
Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa.
Klaas
Phindile J
PJ
Lobb
Kevin A
KA
Pakade
Vusumzi E
VE
Kaye
Perry T
PT
D008956:Models, Chemical; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*
D011804:Quinolines; C037219:quinoline