In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin.
Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.
Jones-Brando
Lorraine
L
Stanley Division of Developmental Neurovirology, Dept. of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287-4988, USA. lbrando@jhmi.edu
D'Angelo
John
J
Posner
Gary H
GH
Yolken
Robert
R
D000818:Animals; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005347:Fibroblasts / Q000187:drug effects* / Q000469:parasitology*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012867:Skin / Q000166:cytology; D014122:Toxoplasma / Q000187:drug effects*
D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin