title: Studies on hepatic lipidosis and coinciding health and fertility problems of high-producing dairy cows using the "Utrecht fatty liver model of dairy cows". A review.
abstract: Fatty liver or hepatic lipidosis is a major metabolic disorder of high-producing dairy cows that occurs rather frequently in early lactation and is associated with decreased health, production and fertility. A background section of the review explores reasons why high-producing dairy cows are prone to develop fatty liver post partum. Hepatic lipidosis and coinciding health and fertility problems seriously endanger profitability and longevity of the dairy cow. Results from a great number of earlier epidemiological and clinical studies made it clear that a different approach was needed for elucidation of pathogenesis and etiology of this complex of health problems. There was a need for an adequate animal model in which hepatic lipidosis and production, health and fertility problems could be provoked under controlled conditions. It was hypothesized that overconditioning ante partum and feed restriction post partum might induce lipolysis in adipose tissue and triacylglycerol accumulation in the liver following calving. This consideration formed the basis for the experiments, which resulted in the "Utrecht fatty liver model of dairy cows". In this model, post partum triacylglycerol-lipidosis as well as the whole complex of health and fertility problems are induced under well-controlled conditions. The experimental protocol based on this hypothesis produced in all cases (10 feeding trials with over 150 dairy cattle) the intended result, i.e. all experimental cows developed post partum higher hepatic triacylglycerol concentrations than did control cows. The model was evaluated in biochemical, clinical pathology, immunological, clinical and fertility terms. It turned out that in this model, post partum triacylglycerol-lipidosis as well as the whole complex of health and fertility problems were induced under well-controlled conditions.
authors.affiliation: Department of Nutrition, Graduate School of Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. m.geelen@vet.uu.nl
authors.forename: M J H
authors.initials: MJ
authors.lastname: Geelen
authors.forename: T
authors.initials: T
authors.lastname: Wensing
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D003612:Dairying / Q000379:methods; D005234:Fatty Liver / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D005298:Fertility; D007774:Lactation / Q000378:metabolism*; D049590:Postpartum Period / Q000378:metabolism; D011247:Pregnancy