title: Identification of selective neuropeptide Y2 peptide agonists.
abstract: Activation of the NPY2 receptor to reduce appetite while avoiding stimulation of the NPY1 and NPY5 receptors that induce feeding provides a pharmaceutical approach to modulate food intake. The naturally occurring peptide PYY(3-36) is a nonselective NPY1, NPY2, and NPY5 agonist. N-terminal truncation of PYY to abrogate affinity for the NPY1 and NPY5 receptors and subsequent N-terminal modification with aminobenzoic analogs to restore NPY2 receptor potency results in a series of highly selective NPY2 receptor peptide agonists.
authors.affiliation: Department of Metabolic Disorders Research, Bayer Pharmaceuticals Corporation, 400 Morgan Lane, West Haven, CT 06516, USA.
authors.forename: Lynn B
authors.initials: LB
authors.lastname: DeCarr
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Buckholz
authors.forename: Philip D G
authors.initials: PD
authors.lastname: Coish
authors.forename: Zahra
authors.initials: Z
authors.lastname: Fathi
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Fisk
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Mays
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: O'Connor
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Lumb
mesh_terms: D001667:Binding, Competitive / Q000187:drug effects; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D004435:Eating / Q000187:drug effects*; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D010446:Peptide Fragments; D019894:Peptide YY / Q000737:chemistry* / Q000494:pharmacology*; D017476:Receptors, Neuropeptide Y / Q000819:agonists* / Q000187:drug effects
chemical_list: D007202:Indicators and Reagents; D010446:Peptide Fragments; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; C095889:neuropeptide Y2 receptor; C100568:neuropeptide Y5 receptor; D019894:Peptide YY; C061785:peptide YY (3-36); D016244:Guanosine 5'-O-(3-Thiotriphosphate)