Highly regioselective catalytic oxidative coupling reactions: synthetic and mechanistic investigations.
A highly efficient and regioselective Pd-catalyzed method for the oxidative coupling of arylpyridine derivatives is reported. Remarkably, the reactions proceed at room temperature and are compatible with diverse functionalities, including aryl halides and thiophenes. Mechanistic studies suggest that these transformations proceed via a previously unprecedented mechanism involving two different pyridine-directed C-H activation reactions-one at a PdII center and one at PdIV.
Hull
Kami L
KL
Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109, USA.
Lanni
Erica L
EL
Sanford
Melanie S
MS
D001688:Biological Products / Q000737:chemistry*; D002384:Catalysis; D010084:Oxidation-Reduction
D001688:Biological Products