Insulin resistance, arterial stiffness and wave reflection.
Insulin resistance is associated with increased cardiovascular morbidity and mortality but the underlying mechanism(s) are incompletely understood. Epidemiological data suggest that insulin resistance and arterial stiffness are interrelated. In insulin sensitive-subjects, insulin acutely decreases the augmentation index as measured using pulse wave analysis. In insulin-resistant subjects, this effect of insulin is blunted implying that insulin resistance involves also large arteries. This may provide one mechanism linking insulin resistance and cardiovascular disease.
Yki-Järvinen
Hannele
H
Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki , Finland.
Westerbacka
Jukka
J
D001158:Arteries / Q000187:drug effects / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance; D011673:Pulsatile Flow / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D007004:Hypoglycemic Agents; D007328:Insulin