Cortical sulci and bipolar disorder.
The width of cortical sulci in bipolar patients (n=19) and healthy controls (n=35) was examined using a novel automated technique involving magnetic resonance imaging. All sulci were wider for bipolar patients than for healthy controls. Bipolar-control differences were largest for the superior and intermediate frontal sulci, smallest for the occipital and cingulate sulci, and intermediate in magnitude for the other sulci (intraparietal, inferior frontal, and central sulci). The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci.
Coyle
Thomas R
TR
Department of Psychology, University of Texas at San Antonio, Texas 78249, USA, and Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Orsay Cedex, France. Thomas.Coyle@utsa.edu
Kochunov
Peter
P
Patel
Rupal D
RD
Nery
Fabiano G
FG
Lancaster
Jack L
JL
Mangin
Jean-François
JF
Rivière
Denis
D
Pillow
David R
DR
Davis
Gregory J
GJ
Nicoletti
Mark A
MA
Serap Monkul
E
E
Fox
Peter T
PT
Soares
Jair C
JC
D000328:Adult; D001284:Atrophy; D001714:Bipolar Disorder / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged