title: Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease.
abstract: An intravascular catheter for Raman spectroscopic detection and analysis of coronary atherosclerotic disease has been developed. The catheter, having an outer diameter of 2 mm, consisted of a side-view-type micro-Raman probe, an imaging fiber bundle, a working channel (injection drain), and a balloon. By inflating the balloon, the probe was brought close to the inner wall of a modeled blood flow system and detected a phantom target buried in the wall. Results obtained demonstrate the possibility of using the spectroscopic catheter for molecular diagnosis of coronary lesions.
authors.affiliation: Tashiro Probing Technology Laboratory, RIKEN The Institute of Physical and Chemical Research, Hirosawa, Wako-shi, Saitama, Japan. komachi@riken.jp
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Komachi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Sato
authors.forename: Hideo
authors.initials: H
authors.lastname: Tashiro
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods
chemical_list: D015415:Biomarkers; D001798:Blood Proteins