Molecular characterization of human adenoviruses isolated in Italy.
There is little information on the epidemiology of Human Adenoviruses (HAdVs) in Italy. In this study, 103 HAdV isolates, collected by the A. Gemelli Hospital (Catholic University Medical School of Rome, Italy) between 1987 and 2005, were genotyped by sequencing and phylogenetic analysis on a partial hexon gene region. Nine different serotypes belonging to all six HAdV species were identified. Serotype 2 was the most frequent (53.4%), followed by serotype 1 (15.53%) and serotype 41 (9.7%). Partial-hexon-based identification was confirmed as an effective tool for studying the molecular epidemiology of HAdVs.
La Rosa
Giuseppina
G
Istituto Superiore di Sanità, Dipartimento Ambiente e Connessa Prevenzione Primaria, Roma, Italy. giuseppina.larosa@iss.it
Muscillo
Michele
M
Iaconelli
Marcello
M
Di Grazia
Antonio
A
Fontana
Stefano
S
Sali
Michela
M
De Carolis
Elena
E
Cattani
Paola
P
Manzara
Stefania
S
Fadda
Giovanni
G
D000258:Adenovirus Infections, Human / Q000453:epidemiology / Q000821:virology*; D000260:Adenoviruses, Human / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012703:Serotyping
D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus