title: Linear relationship of refractive and biometric lenticular changes during accommodation in emmetropic and myopic eyes.
abstract: OBJECTIVE
  Aim of this study was to investigate the relationship between refractive changes in the eye and biometric changes of the human crystalline lens during accommodation. Furthermore, differences in these relationships between young, healthy emmetropic and myopic subjects were analyzed.
  
  
  METHODS
  Mean relative change in anterior chamber depth (ACD), lens thickness (LT), anterior segment length (ASL = ACD + LT) and in objective refraction were simultaneously assessed during near-point-induced accommodation in 10 emmetropic and 10 myopic subjects. Via a beam splitter, measurements were performed simultaneously using partial coherence interferometry (PCI) and infrared (IR) photorefraction.
  
  
  RESULTS
  On average, for each diopter of accommodation LT increased by 0.063 mm in emmetropic and by 0.072 mm in myopic eyes, and ACD decreased by 0.047 mm and 0.057 mm, respectively. Mean ASL, indicating the position of the posterior lens pole, increased by 0.009 mm in emmetropic and by 0.013 mm in myopic eyes. The correlation between refractive and biometric changes was found to be essentially linear in both subgroups. Differences in ACD between emmetropic and myopic eyes were statistically significant at an accommodative stimulus of -1 D (p<0.04) and -2 D (p<0.02).
  
  
  CONCLUSIONS
  The biometric and refractive changes of the human lens are highly correlated and linear in function in both emmetropic and myopic eyes.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Matthias
authors.initials: M
authors.lastname: Bolz
authors.forename: Ana
authors.initials: A
authors.lastname: Prinz
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Drexler
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D000328:Adult; D000867:Anterior Chamber / Q000033:anatomy & histology / Q000473:pathology; D001699:Biometry / Q000379:methods; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D009068:Movement / Q000502:physiology; D009216:Myopia / Q000473:pathology / Q000503:physiopathology*; D015588:Observer Variation; D012029:Refraction, Ocular / Q000502:physiology*