Prostacyclin analogues: prevention of cardiovascular diseases.
Prostacyclin (PGI(2)) inhibits platelet aggregation and vasoconstriction. PGI(2) synthase (PGIS), a catalyst of PGI(2) formation from prostaglandin H2, is widely distributed and predominantly found in vascular endothelial and smooth muscle cells. Vane et al. first discovered PGI(2) in 1976, for which they received the Nobel Prize in medicine and physiology in 1982. However, the later discovery of nitric oxide (NO), which also resulted in a Nobel Prize for the scientists involved, led to less attention being focused on PGI(2). The reason for this is somewhat perplexing and may have been due to the lack of information on how to correctly use PGI(2). Current findings suggest that researchers concentrated too much effort on the therapeutic effects of PGI(2), while largely ignoring the potential for preventative effects. In addition, PGI(2) was shown to be effective against diseases in some studies but was without effect in others. The present paper contains a review of PGI(2) and PGIS, in addition to an examination of the relationship between PGIS gene mutations and cardiovascular diseases. PGI(2) analogues that can be used in the prevention of cardiovascular diseases are also discussed.
Nakayama
Tomohiro
T
Division of Molecular Diagnostics, Advanced Medical Research Center, Nihon University School of Medicine, Ooyaguchi-kamimachi, 30-1 Itabashi-ku, Tokyo 173-8610, Japan. tnakayam@med.nihon-u.ac.jp
D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004358:Drug Therapy / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000517:prevention & control*; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044062:Prostaglandins I / Q000819:agonists* / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic / Q000379:methods
D044062:Prostaglandins I; D003577:Cytochrome P-450 Enzyme System; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase