title: Gracilarioside and gracilamides from the red alga Gracilaria asiatica.
abstract: One gracilarioside and two gracilamides with unusual cyclopropane-containing alkyl chains were isolated from the red alga Gracilaria asiatica. Their structures were determined by spectroscopic methods and microscale chemical degradation. To our knowledge, no ceramides with a cyclopropane ring have been reported from marine organisms. These three compounds were mildly cytotoxic to the human A375-S2 melanoma cell line.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Youjun
authors.initials: Y
authors.lastname: Xu
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Huiming
authors.initials: H
authors.lastname: Hua
authors.forename: He
authors.initials: H
authors.lastname: Zhu
authors.forename: Yuehu
authors.initials: Y
authors.lastname: Pei
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D003521:Cyclopropanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D044724:Gracilaria / Q000737:chemistry*; D006801:Humans; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D003521:Cyclopropanes; D008387:Marine Toxins; C515267:gracilamide A; C515268:gracilamide B; C515266:gracilarioside