Safety and usefulness of a novel eMotion electric mesh nebulizer in children with asthma.
BACKGROUND
A new electronic mesh nebulizer, eMotion is known to have higher performance compared to conventional nebulizers. However, there are some concerns about whether too much delivered dose might cause side effects with higher frequency.


METHODS
To evaluate the safety and usefulness of the nebulizer, we measured changes in heart rates and lung functions of 73 asthmatic children when they inhaled 1 microg/kg of procaterol with eMotion or a conventional nebulizer, Junior BOY.


RESULTS
In 34 children with mild asthma exacerbation, physical findings, lung function and transcutaneous oxygen saturation levels were improved after inhalation using both nebulizers. No adverse effects including significant increase of heart rate were found. Improvements in the rates of the parameters were comparable. When response to beta2-agonist inhalation was checked in 39 children in stable condition, similar degrees of improvement in lung function were observed, and heart rates did not change after inhalation with either nebulizers.


CONCLUSIONS
Safety and efficacy was comparable between eMotion and a conventional nebulizer when it was used to administer beta2-agonists in asthmatic children. However, from the fact that eMotion needs only 3-4 minutes to inhale 2 mL solution, eMotion could be more useful for most children who usually do not prefer longer inhalation time with conventional compressor nebulizers.
Saeki Adachi
Yoko
Y
Department of Pediatrics, Faculty of Medicine, University of Toyama, Sugiahi, Toyama, Japan.
Itazawa
Toshiko
T
Nakabayashi
Motokazu
M
Fuchizawa
Tatsuya
T
Okabe
Yoshie
Y
Ito
Yasunori
Y
Adachi
Yuichi
Y
Murakami
Gyokei
G
Miyawaki
Toshio
T
D000280:Administration, Inhalation; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D017265:Procaterol / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D016896:Treatment Outcome
D000318:Adrenergic beta-Agonists; D017265:Procaterol