title: Regulatory modules that generate biphasic signal response in biological systems.
abstract: Biochemical networks might be composed of modules. It is still not clear how biochemical modules can be defined and characterised. Here we propose a functional approach to module definition, considering different classes of biphasic regulation modules, which effect optimal cell response to intermediate signal strength. Each regulation class might possess unique properties that make it especially suitable for particular biological functions.
authors.affiliation: Whitaker Institute for Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. alev@bme.jhu.edu
authors.forename: A
authors.initials: A
authors.lastname: Levchenko
authors.forename: J
authors.initials: J
authors.lastname: Bruck
authors.forename: P W
authors.initials: PW
authors.lastname: Sternberg
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D003198:Computer Simulation; D005246:Feedback / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D050436:Regulatory Elements, Transcriptional / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D049490:Systems Biology; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*; D015533:Transcriptional Activation / Q000502:physiology
chemical_list: D014157:Transcription Factors