Assessing health-related quality of life in patients with Parkinson's disease in a prospective longitudinal study.
OBJECTIVE
To prospectively assess the health-related quality of life (HrQoL) in Parkinson's disease (PD) during 12 months.


METHODS
HrQoL was assessed in 145 PD patients using the PD-specific PDQ-39, PDQL and the generic EQ-5D. In addition, clinical rating-scales were used.


RESULTS
All scales showed a pronounced effect of PD. In comparison to an age-matched population the EQ-5D was considerably affected. In comparison to baseline, however, there was no significant change in the generic scale but a significant change in the sum-score of disease-specific HrQoL-scales.


CONCLUSIONS
Only disease-specific scales were sensitive to change. Further studies are necessary to evaluate the time-dependent change in HrQoL.
Reuther
M
M
Department of Neurology, Philipps-University Marburg, Germany.
Spottke
E A
EA
Klotsche
J
J
Riedel
O
O
Peter
H
H
Berger
K
K
Athen
O
O
Köhne-Volland
R
R
Dodel
R C
RC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology*; D011594:Psychometrics; D011788:Quality of Life; D012720:Severity of Illness Index; D018434:Sickness Impact Profile