Effects of taurine, carnosine, and casomorphine on functional activity of rat peritoneal mast cells.
We studied the effects of taurine, carnosine, and casomorphine on histamine release from rat peritoneal mast cells induced by compound 48/80 and ionophore A23187. Differences were revealed in the effect of the test preparations. Taurine inhibited histamine release induced by ionophore A23187, but not by compound 48/80. Carnosine abolished the stimulatory effect of compound 48/80 on histamine release, but did not modulate the effect of ionophore A23187. Casomorphine inhibited histamine release induced by ionophore A23187, but potentiated the effect of compound 48/80. The mechanisms for these effects are discussed.
Akhalaya
M Ya
MY
Laboratory of Radiation Biophysics, Department of Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University. amedea@biophys.msu.ru
Baizhumanov
A A
AA
Graevskaya
E E
EE
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002336:Carnosine / Q000494:pharmacology*; D004723:Endorphins / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D010529:Peritoneal Cavity / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D004723:Endorphins; D010446:Peptide Fragments; D013654:Taurine; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; C041128:beta-casomorphin 7; D002336:Carnosine