Influenza vaccine effectiveness among 50-64-year-old persons during a season of poor antigenic match between vaccine and circulating influenza virus strains: Colorado, United States, 2003-2004.
During the 2003-2004 influenza season, we conducted a case-control study of influenza vaccine effectiveness (VE) among Colorado residents aged 50-64 years. Cases (n=330) were identified from laboratory-confirmed influenza reports to the Colorado Department of Public Health and Environment (CDPHE). Controls (n=1055) were recruited by random-digit dial telephone survey. VE was 60% (43-72%) and 48% (21-66%) among those without and with high-risk medical conditions, respectively. VE was 90% (68-97%) and 36% (0-63%) against influenza-related hospitalization for persons without and with high-risk conditions, respectively.
Herrera
Guillermo A
GA
Centers for Disease Control and Prevention (CDC), National Immunization Program (NIP), Epidemiology and Surveillance Division (ESD), Centers for Disease Control and Prevention, Atlanta, GA 30333, United States. gah9@cdc.gov
Iwane
Marika K
MK
Cortese
Margaret
M
Brown
Cedric
C
Gershman
Ken
K
Shupe
Alyson
A
Averhoff
Francisco
F
Chaves
Sandra S
SS
Gargiullo
Paul
P
Bridges
Carolyn B
CB
D000940:Antigenic Variation; D016022:Case-Control Studies; D003120:Colorado; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification* / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012621:Seasons; D013045:Species Specificity; D016896:Treatment Outcome; D014611:Vaccination / Q000706:statistics & numerical data
D007252:Influenza Vaccines