title: Self-localization of laser induced tumour coagulation limited by heat diffusion through active tissue.
abstract: We analyse necrosis growth due to thermal coagulation induced by laser light absorption and limited by heat diffusion into the surrounding live tissue. The tissue is assumed to contain a tumour in the undamaged tissue where the blood perfusion rate does not change during the action. By contrast, normal tissue responds strongly to an increase in the tissue temperature and the blood perfusion rate can grow by tenfold. We study in detail necrosis formation under conditions typical of a real course of thermal therapy treatment. The duration of the treatment is about 5 minutes when a necrosis domain of about 1 cm or above is formed. In particular, if the tumour size is sufficiently large, i.e. it exceeds 1 cm, and the tissue response is not too delayed, i.e. the delay time does not exceed 1 min, then there are conditions under which the relative volume of the damaged normal tissue is small in comparison with the tumour volume after the tumour is totally coagulated.
authors.affiliation: Institute for Applied Problems in Mechanics and Mathematics, National Academy of Sciences of Ukraine, Naukova Street 3b, 79053, Lviv, Ukraine. vagaf@yahoo.com
authors.forename: B Y
authors.initials: BY
authors.lastname: Datsko
authors.forename: V V
authors.initials: VV
authors.lastname: Gafiychuk
authors.forename: I A
authors.initials: IA
authors.lastname: Lubashevsky
authors.forename: A V
authors.initials: AV
authors.lastname: Priezzhev
mesh_terms: D001831:Body Temperature / Q000528:radiation effects; D003198:Computer Simulation; D003238:Connective Tissue / Q000473:pathology / Q000503:physiopathology* / Q000528:radiation effects; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000379:methods; D017075:Laser Coagulation / Q000009:adverse effects* / Q000379:methods*; D008954:Models, Biological; D009336:Necrosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D011379:Prognosis; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D013813:Therapy, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome