Clinical phenotype of an Italian family with a new mutation in the PRPF8 gene.
OBJECTIVE
To report the clinical and functional characteristics of an autosomal dominant retinitis pigmentosa (ADRP) family with a novel point mutation (P2301S) in the PRPF8 gene.


METHODS
PRPF8 gene analysis and complete ophthalmologic examination in an ADRP family.


RESULTS
Clinical examination revealed the typical RP phenotype in all family members. Electroretinography showed preserved ERG photopic responses. Genetic analysis showed that the P2301S missense mutation segregated with the disease in all subjects.


CONCLUSIONS
Unlike previously reported families, the PRPF8 gene mutation in our family is associated with a mild phenotype in which cone function is partially preserved.
Testa
F
F
Department of Ophthalmology, Second University of Napoli, Napoli, Italy.
Ziviello
C
C
Rinaldi
M
M
Rossi
S
S
Di Iorio
V
V
Interlandi
E
E
Ciccodicola
A
A
Banfi
S
S
Simonelli
F
F
D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D004596:Electroretinography; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D009154:Mutation; D009887:Ophthalmoscopy; D010375:Pedigree; D010641:Phenotype; D016601:RNA-Binding Proteins; D012174:Retinitis Pigmentosa / Q000175:diagnosis / Q000235:genetics*
D002352:Carrier Proteins; C115374:PRPF8 protein, human; D016601:RNA-Binding Proteins; D004247:DNA