Photostabilization of 1,4-dihydropyridine antihypertensives by incorporation into beta-cyclodextrin and liposomes.
Inclusion compounds of eleven dihydropyridine drugs were formed and investigated for protection against photo-induced drug degradation. Formulations of cyclodextrins and liposomes were prepared and their photoprotective ability for the encapsulated drug was monitored. Drug photodegradation was spectrophotometrically followed during exposure of the formulations to light of a Xenon lamp. ICH guidelines for photostability testing were applied. A comparison with common pharmaceutical formulations revealed optimal protection for both formulations. The use of the liposome and cyclodextrin inclusion complexes resulted in a mean drug recovery of 77 and more then 90% respectively, after a light exposure until to 30 minutes with an intensity of 21 kJ x min(-1) m(-2). Lercanidipine and Manidipine only did not show a satisfactory increase of photostabilization in the studied supramolecular complexes, due to their low inclusion in both the systems.
Ragno
G
G
Department of Pharmaceutical Sciences, University of Calabria, 87036-Rende, Italy.
Risoli
A
A
Ioele
G
G
Cione
E
E
De Luca
M
M
D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004095:Dihydropyridines / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects; D004337:Drug Carriers / Q000737:chemistry* / Q000528:radiation effects; D004355:Drug Stability; D008027:Light; D008081:Liposomes / Q000737:chemistry*; D008422:Materials Testing; D010777:Photochemistry / Q000379:methods; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000528:radiation effects
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D020099:Coated Materials, Biocompatible; D004095:Dihydropyridines; D004337:Drug Carriers; D008081:Liposomes; D047392:beta-Cyclodextrins; C038806:1,4-dihydropyridine; C031215:betadex