IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity.
Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain significant quantities of IgG. The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. The FcRn can then recycle the IgG/antigen complex back across the intestinal barrier into the lamina propria for processing by dendritic cells and presentation to CD4(+) T cells in regional organized lymphoid structures. FcRn, through its ability to secrete and absorb IgG, thus integrates luminal antigen encounters with systemic immune compartments and, as such, provides essential host defense and immunoregulatory functions at the mucosal surfaces.
Yoshida
Masaru
M
Frontier Medical Science in Gastroenterology, ICMRT, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan, myoshida@med.kobe-u.ac.jp.
Masuda
Atsuhiro
A
Kuo
Timothy T
TT
Kobayashi
Kanna
K
Claypool
Steven M
SM
Takagawa
Tetsuya
T
Kutsumi
Hiromu
H
Azuma
Takeshi
T
Lencer
Wayne I
WI
Blumberg
Richard S
RS
D000941:Antigens / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D007074:Immunoglobulin G / Q000276:immunology; D009092:Mucous Membrane / Q000276:immunology
D000941:Antigens; D007074:Immunoglobulin G