[Protective and reverse effects of qindan capsule on aortic lesion in spontaneously hypertensive rats].
OBJECTIVE
To investigate the effects and mechanism of Qindan Capsule (QC) on aortic structure in spontaneously hypertensive rats (SHR).


METHODS
Thirty-two SHR of 14 weeks old, were divided into the QC group, the Niuhuang Jiangya Capsule (NJC) group, the captopril group and the model group. Besides, Wistar-Kyoto (WKY) rats were taken as the normal control. All the others were administered with corresponding medicine and their blood pressure measured. After 12 weeks, the morphological changes of aorta were observed by HE and Masson staining, the level of angiotensin II (Ang II) in aorta was detected by radioimmunoassay, and the mRNA expression of basic fibroblast growth factor (bFGF) in aortic wall was analyzed by real-time quantitative fluorescent PCR.


RESULTS
QC could reduce the blood pressure in SHR, improve their aortic structure, lower the Ang II level and inhibit the bFGF mRNA expression in aortic wall (P < 0.05 or P < 0.01), showing a good effect similar to that of captopril (P > 0.05) and better than that of NJC (P < 0.01).


CONCLUSIONS
QC has a significant protective and reverse effect on aortic lesion in SHR. The mechanism may be related to its actions in reducing Ang II level and inhibiting bFGF mRNA expresion in aortic wall.
Wang
Bo
B
Department of Traditional Chinese Medicine, Qilu Hospital affiliated to Shadong University, Jinan.
Zhang
Ji-dong
JD
Jiang
Hong
H
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000473:pathology*; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis / Q000235:genetics; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D002214:Capsules; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; C526717:qindan; D016222:Fibroblast Growth Factor 2; D000804:Angiotensin II