Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis.
The aim of this study was to evaluate the prevalence of vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with various demographic and renal osteodystrophy markers.


METHODS
This cross-sectional, multicenter study was carried out in 273 PD patients with a mean age of 61.7 +/- 10.9 years and mean duration of PD 3.3 +/- 2.2 years. It included 123 female and 150 male patients from 20 centers in Greece and Turkey, countries that are on the same latitude, namely, 36-42 degrees north. We measured 25(OH)D3 and 1.25(OH)2D3 levels and some other clinical and laboratory indices of bone mineral metabolism.


RESULTS
Of these 273 patients 92% (251 patients) had vitamin D deficiency i.e. serum 25(OH)D3 levels less than 15 ng/ml, 119 (43.6%) had severe vitamin D deficiency i.e., serum 25(OH)D3 levels, less than 5 ng/ml, 132 (48.4%) had moderate vitamin D deficiency i.e., serum 25(OH)D3 levels, 5-15 ng/ml, 12 (4.4%) vitamin D insufficiency i.e., serum 25(OH)D3 levels 15 - 30 ng/ml and only 10 (3.6%) had adequate vitamin D stores. We found no correlation between 25(OH)D3 levels and PTH, serum albumin, bone alkaline phosphatase, P, and Ca x P. In multiple regression analyses, the independent predictors of 25(OH)D3 were age, presence of diabetes (DM-CRF), levels of serum calcium and serum 1.25(OH)2D3.


CONCLUSIONS
We found a high prevalence (92%) of vitamin D deficiency in these 273 PD patients, nearly one half of whom had severe vitamin D deficiency. Vitamin D deficiency is more common in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that these patients should be considered for vitamin D supplementation.
Taskapan
H
H
Inonu University Medical School, Department of Medicine, Division of Nephrology, Malatya, Turkey. hulyataskapan@yahoo.com
Ersoy
F F
FF
Passadakis
P S
PS
Tam
P
P
Memmos
D E
DE
Katopodis
K P
KP
Ozener
C
C
Akcicek
F
F
Camsari
T
T
Ates
K
K
Ataman
R
R
Vlachojannis
J G
JG
Dombros
N A
NA
Utas
C
C
Akpolat
T
T
Bozfakioglu
S
S
Wu
G
G
Karayaylali
I
I
Arinsoy
T
T
Stathakis
C P
CP
Yavuz
M
M
Tsakiris
D J
DJ
Dimitriades
A D
AD
Yilmaz
M E
ME
Gültekin
M
M
Oreopoulos
D G
DG
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003928:Diabetic Nephropathies / Q000628:therapy; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology / Q000209:etiology*
D014807:Vitamin D