REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease.
OBJECTIVE
To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects.


METHODS
Overnight polysomnography.


METHODS
Sleep laboratory.


METHODS
Fifteen patients with probable Alzheimer disease (mean age +/-SD, 70.2+/-5.6) and 15 age-matched healthy control subjects (mean age +/- SD, 67.9 +/-5.4).


METHODS
N/A.


RESULTS
Four patients with Alzheimer disease presented REM sleep with-out atonia. One of these patients had all the polysomnographic features of RBD, including behavioral manifestations during REM sleep.


CONCLUSIONS
RBD is rare, but REM sleep without atonia is relatively fre-quent in patients with probable Alzheimer disease, a tauopathy.
Gagnon
Jean-François
JF
Centre d'étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur de Montréal, Qudbec, Canada.
Petit
Dominique
D
Fantini
Maria Livia
ML
Rompré
Sylvie
S
Gauthier
Serge
S
Panisset
Michel
M
Robillard
Alain
A
Montplaisir
Jacques
J
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009123:Muscle Hypotonia / Q000175:diagnosis / Q000453:epidemiology*; D010507:Periodicity; D017286:Polysomnography; D015995:Prevalence; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology*; D051843:Synucleins / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
D051843:Synucleins; D016875:tau Proteins