title: Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.
abstract: Non-alcoholic fatty liver disease (NAFLD) is emerging as a major cause of chronic liver disease in association with the rising prevalence of obesity and type 2 diabetes in the population. Oxidative stress and insulin resistance (IR) are major contributors in the pathogenesis of NAFLD and in the progression from steatosis to steatohepatitis. Recently, Houstis and colleagues reported that reactive oxygen species have a causal role in multiple forms of IR, a phenomenon that can further promote exacerbation of oxidative stress. The improvement of the knowledge of these interrelationships should contribute to elucidate pathogenic pathways and design effective treatments for NAFLD.
authors.affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago-7, Chile. videla@med.uchile.cl
authors.forename: Luis A
authors.initials: LA
authors.lastname: Videla
authors.forename: Ramón
authors.initials: R
authors.lastname: Rodrigo
authors.forename: Julia
authors.initials: J
authors.lastname: Araya
authors.forename: Jaime
authors.initials: J
authors.lastname: Poniachik
mesh_terms: D016207:Cytokines / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009765:Obesity / Q000150:complications / Q000378:metabolism; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D005231:Fatty Acids, Unsaturated; D018836:Inflammation Mediators