title: Effect of local anesthetics on the electrical characteristics of an excitable model membrane composed of dioleyl phosphate II. Dynamic response.
abstract: The effects of local anesthetics (tetracaine, procaine and lidocaine) on self-sustained electrical oscillations were studied for a lipid membrane comprising dioleyl phosphate (DOPH). This model membrane exhibits oscillation of the membrane potential in a manner similar to that of nerve membranes, i.e., repetitive firing, in the presence of an ion-concentration gradient, on the application of d.c. electric current. Relatively weak anesthetics such as procaine and lidocaine increased the frequency of self-sustained oscillation, and finally induced aperiodic, rapid oscillation. The strong anesthetic tetracaine inhibited oscillation.
authors.affiliation: Department of Home Economics, Kyushu Junior College of Kinki University, Iizuka 820, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iiyama
authors.forename: K
authors.initials: K
authors.lastname: Toko
authors.forename: T
authors.initials: T
authors.lastname: Murata
authors.forename: Y
authors.initials: Y
authors.lastname: Suezaki
authors.forename: H
authors.initials: H
authors.lastname: Kamaya
authors.forename: I
authors.initials: I
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Yamafuji