Coagulopathy in two patients with cystic fibrosis treated with ciprofloxacin.
We report two cases of prolonged blood clotting times as demonstrated by a raised international normalised ratio and elevated activated partial thromboplastin time in patients with cystic fibrosis taking ciprofloxacin. The potential mechanisms of a coagulopathy of this picture as an adverse drug reaction with ciprofloxacin are discussed along with the possible clinical consequences for patients with cystic fibrosis.
Moore
Gillian C
GC
Manchester Adult Cystic Fibrosis Unit, North West Lung Centre, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester, M23 9LT, UK. gillmoore@doctors.net.uk
Redfern
Jan
J
Shiach
Caroline R
CR
Webb
Kevin
K
Jones
Andrew M
AM
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001778:Blood Coagulation Disorders / Q000209:etiology*; D002939:Ciprofloxacin / Q000009:adverse effects*; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D010314:Partial Thromboplastin Time; D011552:Pseudomonas Infections / Q000188:drug therapy*
D000890:Anti-Infective Agents; D002939:Ciprofloxacin