title: Heritability of dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their sisters.
abstract: OBJECTIVE
  To test the hypothesis that adrenal androgen (AA) secretion is an inherited trait in PCOS and that serum DHEAS concentrations, as a marker of AA secretion, will be correlated between women with PCOS and their sisters.
  
  
  METHODS
  Prospective case-control.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  Sixty-two PCOS probands and 69 sisters.
  
  
  METHODS
  None.
  
  
  METHODS
  The DHEAS concentrations and clinical phenotypes were obtained. Familial correlation between sisters was estimated. A variance components model was used to estimate the heritability (h(2)) of the DHEAS levels. Body mass index (BMI)-adjusted DHEAS levels were used in all of the analyses.
  
  
  RESULTS
  There was no difference in age between the proband and sister groups (28.7 +/- 8.1 years vs. 28.0 +/- 8.8 years, P=.65), and probands had higher BMI values (33.4 +/- 7.6 kg/m(2) vs. 27.9 +/- 7.0 kg/m(2), P<.001). Sixteen of the 69 (23.2%) sisters were affected by PCOS. The sister-sister correlation of DHEAS level was 0.28 +/- 0.12 for the whole group (P<.05), and this correlation was higher, at 0.38 +/- 0.14 (P< or =.05), after excluding 31% of the affected sisters and 34% of the unaffected sisters who received hormonal therapy at or within 3 months of the time of the study. The h(2) estimates of DHEAS were 0.43 (P=.037) and 0.44 (P=.062) when all sisters and only untreated sisters, respectively, were included in the analysis.
  
  
  CONCLUSIONS
  The correlation of serum DHEAS levels between PCOS probands and their sisters suggests a familial component in the regulation of DHEAS levels and possibly AA production in PCOS. The h(2) estimates of 0.43-0.44 for BMI-adjusted DHEAS suggest that genetic factors account for between 40% and 50% of the overall variation in DHEAS levels in these women. Our results support the hypothesis that circulating AA levels represent an inherited trait in PCOS.
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism Unit, Ankara, Turkey.
authors.forename: Bulent O
authors.initials: BO
authors.lastname: Yildiz
authors.forename: Mark O
authors.initials: MO
authors.lastname: Goodarzi
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Guo
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.forename: Ricardo
authors.initials: R
authors.lastname: Azziz
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood*; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000151:congenital / Q000235:genetics*; D035781:Siblings
chemical_list: D000728:Androgens; D015415:Biomarkers; D003687:Dehydroepiandrosterone