title: Replacement of chordae tendineae with polytetrafluoroethylene (PTFE) sutures in mitral valve repair: early and long-term results.
abstract: OBJECTIVE
  A variety of reliable techniques are now available for chordal disease management and repair of the anterior mitral valve leaflet prolapse. The study aim was to review the authors' experience with polytetrafluoroethylene (PTFE), using a standardized technique for length adjustment, and to analyze the long-term results in patients who underwent mitral valve repair.
  
  
  METHODS
  A total of 111 patients (mean age 56.2 +/- 16.1 years) underwent mitral valve repair with PTFE neochordae, in addition to a variety of other surgical procedures. Etiologies were degenerative in 82 patients (73.9%), Barlow disease in 13 (11.7%), rheumatic in 10 (9%), and infection in six (5.4%). Prolapse of the anterior leaflet was present in 78 patients (70.3%), of the posterior leaflet in 15 (13.5%), a bileaflet prolapse was present in 12 (10.8%), and a commissural prolapse in six (5.4%). In all cases the anterior annulus was used as the reference level in order to assess the appropriate length of the PTFE neochordae.
  
  
  RESULTS
  The mean number of PTFE neochordae used was 6 +/- 4 per patient. In-hospital mortality was 1.8% (n = 2); mean follow up was 36.8 +/- 25.6 months (range: 12-94 months). There were no late deaths. At five years postoperatively the patient overall survival was 98.2 +/- 1.8%, freedom from reoperation rate 100%, and freedom from grade 1+ mitral regurgitation rate 97.2 +/- 2.8%. There were no documented thromboembolism or hemorrhagic events.
  
  
  CONCLUSIONS
  In degenerative and myxomatous mitral valve disease, leaflet prolapse can be successfully repaired by implantation of PTFE neochordae. Both immediate and long-term results proved the versatility, efficiency and durability of this technique.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, St. Luc Hospital, Catholic University of Leuven, Brussels, Belgium. bruno_chiappini@hotmail.com
authors.forename: Bruno
authors.initials: B
authors.lastname: Chiappini
authors.forename: Alvaro
authors.initials: A
authors.lastname: Sanchez
authors.forename: Philippe
authors.initials: P
authors.lastname: Noirhomme
authors.forename: Robert
authors.initials: R
authors.lastname: Verhelst
authors.forename: Jean
authors.initials: J
authors.lastname: Rubay
authors.forename: Alain
authors.initials: A
authors.lastname: Poncelet
authors.forename: Jean Christophe
authors.initials: JC
authors.lastname: Funken
authors.forename: Gebrine
authors.initials: G
authors.lastname: El Khoury
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002815:Chordae Tendineae / Q000601:surgery*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000401:mortality; D008945:Mitral Valve Prolapse / Q000601:surgery*; D011138:Polytetrafluoroethylene; D012720:Severity of Illness Index; D016019:Survival Analysis; D013537:Sutures; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011138:Polytetrafluoroethylene