title: The twentieth century struggle to decipher insulin signalling.
abstract: Following the discovery of insulin, it took the rest of the twentieth century to understand how this hormone regulates intracellular metabolism. What are the main discoveries that led to our current understanding of this process? And how is this new knowledge being exploited in an attempt to develop improved drugs to treat the epidemic of type-2 diabetes?
authors.affiliation: Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, The Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK. p.cohen@dundee.ac.uk
authors.forename: Philip
authors.initials: P
authors.lastname: Cohen
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010770:Phosphotransferases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D007328:Insulin; D010770:Phosphotransferases; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases; D005947:Glucose