title: Thyroid hormone synthesis and secretion in humans after 80 milligrams of iodine for 15 days and subsequent withdrawal.
abstract: BACKGROUND
  In animals, acute iodine administration results in acute intrathyroidal inhibition of iodinations followed by escape of the inhibition if the excessive iodine intake continues. In humans, the intrathyroidal nonhormonal and hormonal iodine concentration after exposure to large doses of iodine for a relatively long period of time is not known.
  
  
  OBJECTIVE
  To determine whether, in human thyroid, administration of large doses of iodine for a relatively long time results in alterations of intrathyroidal hormonal (HI) T4 and T3 and total iodine (TI) content, as well as whether changes in serum concentration of thyroid hormones and TSH would occur after iodine administration or discontinuation.
  
  
  METHODS
  In 33 euthyroid patients with single thyroid nodule or hyperparathyroidism, Lugol solution (80 mg iodine) was administered for 15 d before operation. Groups of six to eight patients underwent operation 0, 5, 10, and 15 d after iodine withdrawal. TI, HI in a sample of thyroid tissue, and serum concentration of T4, T3, and TSH were measured. In 21 normal euthyroid subjects who did not undergo operation, a similar protocol was used and serial blood measurements were taken.
  
  
  METHODS
  Intrathyroidal TI, HI, and serum thyroid hormone and TSH measurements were the main outcome measure.
  
  
  RESULTS
  Intrathyroidal HI content and serum T4 and T3 were unchanged during and after iodine discontinuation. TI was increased during iodine administration and returned to control values 5 d after discontinuation of iodine. The ratio of HI/TI was decreased and returned to control values 15 d after the iodine was discontinued. Serum TSH was increased during iodine administration and returned to control values 10 d after iodine withdrawal.
  
  
  CONCLUSIONS
  In humans, administration of iodine for a relatively long period of time was accompanied by increased intrathyroidal TI, but no changes in HI or demonstrable increases of serum T4 and T3 were observed. It is hypothesized that the maintenance of normal intrathyroidal HI is the result of the combined inhibitory effect of iodine on thyroid hormone synthesis and on the release of T4 and T3 from the thyroid.
authors.affiliation: Department of Medicine, Division of Endocrinology, University of Patras Medical School, Patras 24500, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Theodoropoulou
authors.forename: Apostolos G
authors.initials: AG
authors.lastname: Vagenakis
authors.forename: Maria
authors.initials: M
authors.lastname: Makri
authors.forename: Kostas B
authors.initials: KB
authors.lastname: Markou
mesh_terms: D006801:Humans; D007455:Iodine / Q000008:administration & dosage*; D013963:Thyroid Hormones / Q000096:biosynthesis / Q000097:blood* / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine