title: Postinfantile giant-cell hepatitis associated with ulcerative colitis and autoimmune hepatitis.
abstract: Postinfantile giant cell hepatitis (PGCH) is rare. It is characterized by the presence of multinucleated giant cells in liver biopsy, and although it has been associated with several etiological agents, in many cases its etiology remains unclear. The case is presented herein of an adult woman with PGCH in the setting of ulcerative colitis and autoimmune hepatitis. The presence of autoimmune hepatitis in the patient is consistent and supports the autoimmune pathogenesis of PGCH in a subgroup of patients. Furthermore, this finding, along with others, suggests that PGCH may be included in the list of hepatic complications of inflammatory bowel disease.
authors.affiliation: Department of Gastroenterology, Hellenic Air Force and Veterans Hospital, Athens, Greece. gkanagnostopoulos@yahoo.gr
authors.forename: George K
authors.initials: GK
authors.lastname: Anagnostopoulos
authors.forename: George
authors.initials: G
authors.lastname: Margantinis
authors.forename: Stavros
authors.initials: S
authors.lastname: Tsiakos
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kostopoulos
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Grigoriadis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Arvanitidis
mesh_terms: D000328:Adult; D001706:Biopsy; D049448:Cholangiopancreatography, Magnetic Resonance; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*