title: Competition between plasmid-bearing and plasmid-free organisms in the host: population dynamics and antibiotic resistance.
abstract: OBJECTIVE
  To clarify the effects of antibiotic exposure on bacterial antibiotic resistance.
  
  
  METHODS
  A competitive population dynamics model for plasmid-bearing organisms and plasmid-free organisms in the host was established. The Poincaré-Bendixson theorem was used for analysis.
  
  
  RESULTS
  All possible results of the competition dependent on biologically meaningful parameters were obtained, which can be classified into eight categories. With the outcomes of the plasmid model, we discussed the sterilizing effect if an antibiotic was added to the host.
  
  
  CONCLUSIONS
  When antibiotic-resistant bacteria existed in a host, a higher dosage of antibiotics was needed with an increased risk of survival of plasmid-bearing organisms and greater danger of resistance to antibiotics.
authors.affiliation: School of Life Science, Qufu Normal University, Qufu, Shandong, PR China. yy.peng@263.net
authors.forename: Hui-Xing
authors.initials: HX
authors.lastname: Song
authors.forename: Yuan-Ying
authors.initials: YY
authors.lastname: Peng
authors.forename: Zhi-Fu
authors.initials: ZF
authors.lastname: Zhu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001424:Bacterial Infections; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D049109:Cell Proliferation; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D008954:Models, Biological; D010957:Plasmids / Q000235:genetics* / Q000378:metabolism; D011157:Population Dynamics; D014169:Transformation, Bacterial / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins