In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci.
The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.
Kamysz
Wojciech
W
Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.
Silvestri
Carmela
C
Cirioni
Oscar
O
Giacometti
Andrea
A
Licci
Alberto
A
Della Vittoria
Agnese
A
Okroj
Marcin
M
Scalise
Giorgio
G
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004357:Drug Synergism; D006095:Gram-Positive Cocci / Q000145:classification / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008074:Lipoproteins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D008074:Lipoproteins; D010455:Peptides