title: [Clinicopathology analysis of mesenchymal chondrosarcoma in soft tissue].
abstract: OBJECTIVE
  To investigate the clinicopathological and immunohistochemical characteristics of soft tissue mesenchymal chondrosarcoma.
  
  
  METHODS
  The clinical material, pathological and immunohistochemical characteristics (reaction to LCA, CD3, CD20, CD45RO, CD79a, CD99, NSE, S-100, Syn, CgA, CK7, CK19, EMA, Coll-II, Sarcomeric-Actin, Desmin, Ki-67,P53) of 2 cases of soft tissue mesenchymal chondrosarcoma in Jishuitan Hospital between 1995 and 2005 were reviewed and followed up.
  
  
  RESULTS
  The two patients were both females. The tumors were located in the low extremity muscles. The main roentgenographical appearance was stippled calcification in tumor and calcification at the edge of the tumor. The histological characteristic features showed undifferentiated small cells together with islands of chondrosarcoma; there was hemangiopericytoma-like arrangement of small cells. The tumor cells were positive for CD99, NSE, Syn, CgA; The cells in chondroid matrix were positive for S-100; chondroid matrix was positive for Coll-II. All tumor cells were negative for LCA, CD3, CD20, CD45RO, CD79a,Sarcomeric-actin, Desmin and CK7, CK19, and EMA. The patient with followed radiotherapy was alive. and the other without radiotherapy dead.
  
  
  CONCLUSIONS
  Mesenchymal chondrosarcoma of soft tissue has the characteristics of primary mesenchyme which differentiates to congenital cartilage. The pathological characteristics of bimophic pattern and roentgenographical appearance of tumor are useful for diagnosis. The prognosis is poor.
authors.affiliation: Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100083, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Cai
authors.forename: Zi Fen
authors.initials: ZF
authors.lastname: Gao
authors.forename: Xiao Yuan
authors.initials: XY
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D018951:Antigens, CD20 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D018211:Chondrosarcoma, Mesenchymal / Q000378:metabolism / Q000473:pathology*; D003893:Desmin / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex; D003893:Desmin; D053552:Keratin-7; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53