Phenolic marine natural products as aldose reductase inhibitors.
Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.
Manzanaro
Sonia
S
Instituto Biomar, S.A., Polígono Industrial, Edificio CEEI, 24231 Onzonilla, León, Spain.
Salva
Javier
J
de la Fuente
Jesús Angel
JA
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D048289:Imidazolidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D053778:Thiazolidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry
D001688:Biological Products; D048289:Imidazolidines; D009281:Naphthalenes; D011799:Quinazolines; D053778:Thiazolidines; C040550:tolrestat; C064920:FR 74366; C038131:epalrestat; D012236:Rhodanine; C484670:AKR1B1 protein, human; D000449:Aldehyde Reductase; C026411:sorbinil