title: Bilateral perysilvian polymicrogyria in Chiari I malformation.
abstract: METHODS
  We report on a 7-year-old girl with generalized epilepsy and mental retardation.
  
  
  CONCLUSIONS
  Neurologic examination was normal and only facial dysmorphic features, compatible with frontonasal dysplasia, were observed. However, magnetic resonance imaging (MRI) revealed Chiari I malformation together with bilateral opercular polymicrogyria. To our knowledge, this is the first report of the association of these developmental disorders. This condition raises questions regarding the ethiopathogenetic classification of Chiari spectrum and as to whether embryologic and genetic causes could be potentially interconnected.
authors.affiliation: Child Neurology Division, Department of Pediatrics, University La Sapienza, Viale Regina Elena, 324, 00161, Rome, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Spalice
authors.forename: Pasquale
authors.initials: P
authors.lastname: Parisi
authors.forename: Mario
authors.initials: M
authors.lastname: Mastrangelo
authors.forename: Francesca
authors.initials: F
authors.lastname: De Luca
authors.forename: Alberto
authors.initials: A
authors.lastname: Verrotti
authors.forename: Paola
authors.initials: P
authors.lastname: Iannetti
mesh_terms: D001139:Arnold-Chiari Malformation / Q000473:pathology*; D002531:Cerebellum / Q000002:abnormalities*; D002540:Cerebral Cortex / Q000002:abnormalities*; D002648:Child; D004829:Epilepsy, Generalized / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008607:Intellectual Disability / Q000473:pathology; D008279:Magnetic Resonance Imaging