Synthesis and surface activity of diether-linked phosphoglycerols: potential applications for exogenous lung surfactants.
The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs were measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants.
Notter
Robert H
RH
Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA.
Wang
Zhongyi
Z
Wang
Zhengdong
Z
Davy
Jason A
JA
Schwan
Adrian L
AL
D005994:Glycerophosphates / Q000138:chemical synthesis* / Q000737:chemistry; D011663:Pulmonary Surfactants / Q000138:chemical synthesis* / Q000737:chemistry; D013500:Surface Tension; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry
D005994:Glycerophosphates; D011663:Pulmonary Surfactants; D013501:Surface-Active Agents