Loss of a notch activity in the developing central nervous system leads to increased cell death.
Fishell
Gord
G
D000818:Animals; D016923:Cell Death / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism*; D016548:Prosencephalon / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D051881:Receptor, Notch1 / Q000235:genetics*; D000071656:Receptor, Notch3; D051880:Receptors, Notch / Q000235:genetics; D013234:Stem Cells / Q000378:metabolism*; D015854:Up-Regulation / Q000235:genetics
C497762:Notch1 protein, mouse; C499373:Notch3 protein, mouse; D051881:Receptor, Notch1; D000071656:Receptor, Notch3; D051880:Receptors, Notch