Coactivator control of cardiovascular growth and remodeling.
Transcriptional coactivators enhance gene expression by associating with sequence-specific transcription factors and serve as the primary targets of developmental and physiological signals in diverse biological processes. Recent studies have revealed key roles for transcriptional coactivators in the control of gene expression during development, growth and remodeling of the cardiovascular system. Based on the importance of the cardiovascular coactivators identified to date, coactivator control is emerging as a central regulatory mechanism in development and homeostasis of the cardiovascular system and other tissues.
Liu
Ning
N
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX 75390, USA.
Olson
Eric N
EN
D000818:Animals; D002148:Calmodulin-Binding Proteins / Q000235:genetics / Q000378:metabolism; D002319:Cardiovascular System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D038081:Organogenesis / Q000235:genetics*; D017434:Protein Structure, Tertiary / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics*; D000099251:Myocardin
D002148:Calmodulin-Binding Proteins; D009687:Nuclear Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000099251:Myocardin; C511044:CAMTA2 protein, mouse