title: In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci.
abstract: The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.
authors.affiliation: Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kamysz
authors.forename: Carmela
authors.initials: C
authors.lastname: Silvestri
authors.forename: Oscar
authors.initials: O
authors.lastname: Cirioni
authors.forename: Andrea
authors.initials: A
authors.lastname: Giacometti
authors.forename: Alberto
authors.initials: A
authors.lastname: Licci
authors.forename: Agnese
authors.initials: A
authors.lastname: Della Vittoria
authors.forename: Marcin
authors.initials: M
authors.lastname: Okroj
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scalise
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004357:Drug Synergism; D006095:Gram-Positive Cocci / Q000145:classification / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008074:Lipoproteins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D008074:Lipoproteins; D010455:Peptides