Optimizing antimicrobial host defense peptides.
Antimicrobial host defense peptides constitute a major component of innate immune systems. Expectations are high to develop them into a novel class of anti-infective agents. In this issue of Chemistry & Biology, Hilpert et al. describe new design and peptide synthesis strategies for systematically investigating such concepts.
Sahl
Hans Georg
HG
University of Bonn, Institute for Medical Microbiology, Immunology and Parasitology, Pharmaceutical Microbiology Unit, Meckenheimer Allee 168, 53115 Bonn, Germany.
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000276:immunology / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000276:immunology / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides