Ligand-selective determinants in gonadotropin receptors.
In mammals, the interactions between gonadotropins and their cognate receptors are highly specific; unintended cross-reactivity under normal physiological conditions has not been observed. This paper summarizes the comparative structure-function studies that aim at elucidating the molecular basis of the ligand selectivity.
Bogerd
J
J
Department of Endocrinology, Utrecht University, Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands. j.bogerd@bio.uu.nl
D000818:Animals; D001665:Binding Sites; D006062:Gonadotropins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D017434:Protein Structure, Tertiary; D011967:Receptors, Gonadotropin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship
D006062:Gonadotropins; D008024:Ligands; D011967:Receptors, Gonadotropin