Gracilarioside and gracilamides from the red alga Gracilaria asiatica.
One gracilarioside and two gracilamides with unusual cyclopropane-containing alkyl chains were isolated from the red alga Gracilaria asiatica. Their structures were determined by spectroscopic methods and microscale chemical degradation. To our knowledge, no ceramides with a cyclopropane ring have been reported from marine organisms. These three compounds were mildly cytotoxic to the human A375-S2 melanoma cell line.
Sun
Yi
Y
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Xu
Youjun
Y
Liu
Kai
K
Hua
Huiming
H
Zhu
He
H
Pei
Yuehu
Y
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D003521:Cyclopropanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D044724:Gracilaria / Q000737:chemistry*; D006801:Humans; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000970:Antineoplastic Agents; D003521:Cyclopropanes; D008387:Marine Toxins; C515267:gracilamide A; C515268:gracilamide B; C515266:gracilarioside