[The value of serum endostatin level in early diagnosis of lung cancer].
OBJECTIVE
To investigate value of serum endostatin level in early diagnosis of lung cancer.


METHODS
ELISA was used to detect the level of serum endostatin at in 40 lung carcinoma patients, 18 males and 4 females, aged 59.50 +/- 14.58. The serum endostatin levels of the lung cancer patients at different clinical stage and of different pathological types were analyzed. The change of serum endostatin level before and after chemotherapy was observed. Twenty patients with benign lung disease and 20 normal persons were used as controls.


RESULTS
(1) The serum endostatin level of the lung cancer patients was 10.71 +/- 9.99) ng/ml, significantly higher than those of the patients with benign lung diseases and the normal persons (4.79 +/- 1.23 ng/ml and 4.51 +/- 1.14 ng/ml, respectively, both P < 0.01). (2) The serum endostatin level of the lung cancer patients at the stage I and II were 13.63 +/- 13.13 ng/ml and 12.35 +/- 5.79 ng/ml respectively, booth significantly higher than that of the patients at the stage III (6.29 +/- 1.64, P = 0.023 and P = 0.023). (3) There were no significant differences in the serum endostatin level among the lung cancer patients with different pathological types. (4) The serum endostatin level of the lung cancer patients after chemotherapy was 7.83 +/- 1.48 ng/ml, significantly higher than that before the chemotherapy (5.59 +/- 1.74, P = 0.04).


CONCLUSIONS
(1) Rising in lung cancer at stages I and II, level of serum may probably be used as the a sign in early diagnosis of lung cancer. (2) After chemotherapy the level of endostatin has a trend of rising. The changes of serum endostatin level will be used as a sign in observation of treatment and prognosis.
Xu
Ai-hui
AH
Department of Respiratory Medicine, Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
Yin
Yan-wei
YW
Chen
Fei-hu
FH
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology; D000368:Aged; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D042241:Early Diagnosis; D043169:Endostatins / Q000097:blood*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012698:Serologic Tests
D043169:Endostatins