title: Slight and short-lasting increase of serum S-100B protein in extra-cranial trauma.
abstract: OBJECTIVE
  Serum S-100B protein is an established biochemical marker of traumatic brain injury. At the same time, the question of extra-cranial S-100B release has been raised. This study evaluates the post-traumatic and post-operative release kinetics of S-100B in 45 trauma victims without head injury.
  
  
  METHODS
  Serum S-100B protein was measured on admission and every 24 hours for 4 consecutive days.
  
  
  RESULTS
  Initial S-100B was slightly increased (median: 0.54 microg L-1) and correlated with the severity of extra-cranial trauma (p = 0.0004, Mann-Whitney test). Both severely (abdominal or chest trauma with or without bone fractures) and mildly (long bone fractures) injured showed a rapid decline of S-100B (< 0.2 microg L-1) around 72 hours post-trauma. Extra-cranial surgery caused a secondary increase of S-100B, especially in the mildly injured group (p = 0.004, Wilcoxon signed rank test).
  
  
  CONCLUSIONS
  Extra-cranial injury results in a mild elevation of serum S-100B protein that declines rapidly (1-3 days after injury).
authors.affiliation: Department of Neurosurgery, University of Athens, Evangelismos Hospital, Athens, Greece. skorfias@mail.gr
authors.forename: Stefanos
authors.initials: S
authors.lastname: Korfias
authors.forename: George
authors.initials: G
authors.lastname: Stranjalis
authors.forename: Christina
authors.initials: C
authors.lastname: Psachoulia
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vasiliadis
authors.forename: Marinos
authors.initials: M
authors.lastname: Pitaridis
authors.forename: Efstathios
authors.initials: E
authors.lastname: Boviatsis
authors.forename: Damianos E
authors.initials: DE
authors.lastname: Sakas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood* / Q000601:surgery; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D018709:Statistics, Nonparametric; D013997:Time Factors; D015599:Trauma Severity Indices
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins