title: Nodular basal cell carcinoma in Gorlin's syndrome treated with systemic photodynamic therapy and interstitial optical fiber diffuser laser.
abstract: Nodular basal cell carcinomas resistant to multiple forms of treatment in two patients with nevoid basal cell carcinoma syndrome (Gorlin's syndrome) were treated with systemic porfimer sodium-based photodynamic therapy. Interstitially placed optical diffuser fibers were used to deliver light. Good response to treatment was seen on clinical evaluation and on measurement by a 20-MHz high-resolution ultrasound.
authors.affiliation: Dermatology Centre, Hope Hospital, Salford, Manchester, M6 8HD, UK.
authors.forename: Vishal
authors.initials: V
authors.lastname: Madan
authors.forename: Juliette A
authors.initials: JA
authors.lastname: Loncaster
authors.forename: Donald
authors.initials: D
authors.lastname: Allan
authors.forename: John T
authors.initials: JT
authors.lastname: Lear
authors.forename: Linda
authors.initials: L
authors.lastname: Sheridan
authors.forename: Catherine
authors.initials: C
authors.lastname: Leach
authors.forename: Ernest
authors.initials: E
authors.lastname: Allan
mesh_terms: D000328:Adult; D001478:Basal Cell Nevus Syndrome / Q000188:drug therapy*; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D055095:Optics and Photonics; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D017319:Photosensitizing Agents; D017323:Dihematoporphyrin Ether