Role of macrophage metalloelastase in gut inflammation.
Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases.
Pender
Sylvia L F
SL
Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK. s.pender@soton.ac.uk
Li
C K F
CK
Di Sabatino
A
A
Sabatino
A D I
AD
MacDonald
T T
TT
Buckley
M G
MG
D003093:Colitis, Ulcerative / Q000201:enzymology / Q000503:physiopathology; D003424:Crohn Disease / Q000201:enzymology / Q000503:physiopathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000201:enzymology / Q000503:physiopathology*; D053508:Matrix Metalloproteinase 12; D008666:Metalloendopeptidases / Q000502:physiology*
D008666:Metalloendopeptidases; C507122:MMP12 protein, human; D053508:Matrix Metalloproteinase 12