Immunoglobulin alpha heavy chain derived from human epithelial cancer cells promotes the access of S phase and growth of cancer cells.
It is generally believed that under normal conditions only B lymphocytes express immunoglobulin. Interestingly, our previous work demonstrated that epithelial cancer tissues and cancer cell lines also express Ig alpha heavy chain. So we further analyzed the potential function of cancer-derived Ig alpha heavy chain. Here we show that blockade of cancer-derived Ig alpha suppressed the growth and viability of cancer cells. And cancer-derived Ig alpha promotes the malignant proliferation ability of cancer cells. Furthermore, we demonstrated that Ig alpha protein increases the access percentage of S phase from the early mitosis of synchronized cancer cells. Our findings support the important role of cancer-derived Ig alpha as a growth promoter of cancer cells, and reveal a novel molecular mechanism for growth and proliferation of cancer cells.
Zheng
Hui
H
Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, P R China.
Li
Ming
M
Liu
Haidan
H
Ren
Wei
W
Hu
Duo-sha
DS
Shi
Ying
Y
Tang
Ming
M
Cao
Ya
Y
D019138:Antibodies, Blocking / Q000494:pharmacology; D000912:Antibodies, Neoplasm; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects* / Q000276:immunology*; D006367:HeLa Cells; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000302:isolation & purification / Q000494:pharmacology*; D007137:Immunoglobulin alpha-Chains / Q000302:isolation & purification / Q000494:pharmacology*; D009369:Neoplasms / Q000139:chemically induced* / Q000276:immunology*; D016196:S Phase / Q000187:drug effects*
D019138:Antibodies, Blocking; D000912:Antibodies, Neoplasm; D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains