Autocrine growth by granulocyte colony-stimulating factor in malignant mesothelioma.
We report the first case of a malignant mesothelioma expressing not only granulocyte-colony stimulating factor (G-CSF), but also its receptor. A 59-year-old male carpenter underwent a panpleuropneumonectomy, but the tumor relapsed and spread rapidly, accompanied by leukocytosis. The white blood cell count reached 147,000/mm3 (96.2% neutrophils), and the concentration of serum G-CSF was 77 pg/mL. An autopsy demonstrated that some of the tumor cells produced G-CSF, but more tumor cells and endothelial cells in the tumor expressed G-CSF receptor. It was hypothesized that an autocrine loop involving G-CSF and the G-CSF receptor greatly accelerated the tumor growth.
Nishimura
Motohiro
M
Department of Thoracic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Itoh
Kyoko
K
Ito
Kazuhiro
K
Yanada
Masashi
M
Terauchi
Kunihiko
K
Fushiki
Shinji
S
Shimada
Junichi
J
D000008:Abdominal Neoplasms / Q000378:metabolism* / Q000556:secondary; D001201:Ascites; D019898:Autocrine Communication; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000378:metabolism* / Q000556:secondary; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000378:metabolism* / Q000473:pathology; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis
D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor