A proposal for a convenient notation for P-chiral nucleotide analogues. Part 2. Dinucleoside monophosphate analogues.
A configuration of ligands around a phosphorus atom in P-chiral dinucleoside monophosphate analogues can be described using DP/LP stereochemical notation, which allows immediate correlation between the notation of configuration and the actual spatial arrangement of the phosphorus ligands. The area of applications of this new stereochemical nomenclature covers dinucleoside units bridged by virtually any type of tri-and tetra-coordinated phosphorus moieties, that is, phosphorothioates, phosphoramidates, phosphoramidites, boranephosphates, methanephosphonates, H-phosphonates, and many others.
Sobkowski
Michal
M
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland. msob@ibch.poznan.pl
Stawinski
Jacek
J
Kraszewski
Adam
A
D002621:Chemistry / Q000379:methods*; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D011993:Recombinant Fusion Proteins / Q000737:chemistry; D013237:Stereoisomerism; D009626:Terminology as Topic
D015226:Dinucleoside Phosphates; D008024:Ligands; D009705:Nucleosides; D009711:Nucleotides; D011993:Recombinant Fusion Proteins; D010100:Oxygen