Identification of a hormonal basis for gallbladder filling.
The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.
Choi
Mihwa
M
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Moschetta
Antonio
A
Bookout
Angie L
AL
Peng
Li
L
Umetani
Michihisa
M
Holmstrom
Sam R
SR
Suino-Powell
Kelly
K
Xu
H Eric
HE
Richardson
James A
JA
Gerard
Robert D
RD
Mangelsdorf
David J
DJ
Kliewer
Steven A
SA
D000818:Animals; D002766:Cholecystokinin / Q000097:blood; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology*; D005704:Gallbladder / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger; C108526:fibroblast growth factor 15, mouse; D005346:Fibroblast Growth Factors; D002766:Cholecystokinin; D000242:Cyclic AMP; D006152:Cyclic GMP