Diabetes mellitus following paediatric renal transplantation: a single centre experience.
OBJECTIVE
Post-transplant diabetes mellitus (PTDM) has a variably reported incidence of 4-41% among adults and children. We describe our recent experience of four children with PTDM in a paediatric renal transplantation centre.


METHODS
We undertook a retrospective analysis of the glycaemic status of all paediatric patients undergoing renal transplantation at our centre in the 2-year study period. The clinical features and investigations of those who developed PTDM were further reviewed.


RESULTS
Five episodes of PTDM occurred in 4/32 children. There was a variable onset and a wide range of symptoms. Investigations revealed a combination of insulinopenia with peripheral insulin resistance. Insulin therapy was required for variable durations with resolution of PTDM in four episodes. PTDM did not adversely affect the renal graft function.


CONCLUSIONS
PTDM requires increased awareness among paediatric nephrologists and endocrinologists for early recognition and prompt effective intervention.
Sukthankar
S A
SA
Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester, UK. shaila.sukthankar@CMMC.nhs.uk
Lewis
M A
MA
Webb
N J A
NJ
Plant
N D
ND
Price
D A
DA
Hall
C M
CM
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D012189:Retrospective Studies
D007166:Immunosuppressive Agents