Effect of beer ingestion on the plasma concentrations and urinary excretion of purine bases: one-month study.
To investigate the effect of long-term beer ingestion on the plasma concentrations and urinary excretion of purine bases, 5 healthy males participated in the present study, during which they ingested beer every evening for 30 days. Blood and 24-hour urine samples were collected in the morning one day before and 14 and 30 days after the initiation of the beer ingestion. During the beer ingestion period, the plasma concentration and the urinary excretion of uric acid were increased significantly, while uric acid clearance was not decreased. Further, purine ingestion was not significantly different throughout the study. These results suggest that production of uric acid by ethanol ingestion was the main contributor to the increased plasma uric acid. Therefore, patients with gout should be encouraged to avoid drinking large amounts of beer on a daily basis.
Moriwaki
Y
Y
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. moriwaki@hyo-med.ac.jp
Ka
T
T
Takahashi
S
S
Tsutsumi
Z
Z
Yamamoto
T
T
D019342:Acetic Acid / Q000097:blood; D000428:Alcohol Drinking; D001515:Beer; D000431:Ethanol / Q000097:blood; D006801:Humans; D019271:Hypoxanthine / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011687:Purines / Q000097:blood* / Q000652:urine*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood / Q000378:metabolism; D019820:Xanthine / Q000378:metabolism
D011687:Purines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D000431:Ethanol; D019342:Acetic Acid