title: Efficacy of a novel oral carbapenem, tebipenem pivoxil (TBM-PI), against experimental otitis media caused by penicillin resistant Streptococcus pneumoniae in chinchilla.
abstract: An animal model of otitis media using chinchillas was developed to evaluate the efficacy of tebipenem pivoxil (TBM-PI) against experimental otitis media. Chinchillas inoculated via the transbullar approach with Streptococcus pneumoniae serogroup 6 were included in the efficacy study with TBM-PI, amoxicillin (AMX) or untreated as controls. TBM-PI resulted in survival rate of 83%, compared with 25% survival for AMX and 0% survival for controls (p<0.01). Quantitative cultures in the middle ear effusions at day 5 of the TBM-PI group yielded 3.5+/-2.4log(10)CFUs/ml. TBM-PI is a promising antibiotic for the treatment of acute otitis media.
authors.affiliation: Infection and Immunity Research Center, Wakayama Medical University, Wakayama, Japan.
authors.forename: Muneki
authors.initials: M
authors.lastname: Hotomi
authors.forename: Masaki
authors.initials: M
authors.lastname: Suzumoto
authors.forename: Koju
authors.initials: K
authors.lastname: Itahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Nagura
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Fukushima
authors.forename: Jun
authors.initials: J
authors.lastname: Shimada
authors.forename: Dewan S
authors.initials: DS
authors.lastname: Billal
authors.forename: Kazuma
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Keiji
authors.initials: K
authors.lastname: Fujihara
authors.forename: Noboru
authors.initials: N
authors.lastname: Yamanaka
mesh_terms: D000284:Administration, Oral; D000658:Amoxicillin / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D015780:Carbapenems / Q000493:pharmacokinetics / Q000494:pharmacology*; D002682:Chinchilla; D008297:Male; D023421:Models, Animal; D010033:Otitis Media / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000378:metabolism; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000658:Amoxicillin; C500135:tebipenem