In vitro-clinical correlations for amphotericin B susceptibility in AIDS-associated cryptococcal meningitis.
Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.
Larsen
R A
RA
Department of Medicine (Infectious Diseases), 2020 Zonal Ave., IRD Room 620, MC 9520, University of Southern California, Los Angeles, CA 90033, USA. rlarsen@usc.edu
Bauer
M
M
Brouwer
A E
AE
Sanchez
A
A
Thomas
A M
AM
Rajanuwong
A
A
Chierakul
W
W
Peacock
S J
SJ
Day
N
N
White
N J
NJ
Rinaldi
M G
MG
Harrison
T S
TS
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*; D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D003455:Cryptococcus neoformans / Q000187:drug effects*; D006801:Humans; D016919:Meningitis, Cryptococcal / Q000188:drug therapy / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D012044:Regression Analysis
D000935:Antifungal Agents; D000666:Amphotericin B