title: [Application of the collagen in mastoidectomy].
abstract: OBJECTIVE
  To evaluate the effect of the collage application in mastoidectomy.
  
  
  METHODS
  Forty-one patients (41 ears) with chronic suppurative otitis media (cholesteatoma type) were surgically treated by mastoidectomy, in which 22 cases (22 ears) used collagen and dissociative flap to deal with mastoid cavity but 19 cases (19 ears) without collagen. All patients were followed up for one year to observe the situation after mastoidectomy comparatively.
  
  
  RESULTS
  The epithelization time of mastoid cavity was 3 to 7 weeks, averaging (4.5 +/- 0.7) weeks in the collagen-applying group and was 5 to 12 weeks, averaging (7.2 +/- 0.8) weeks in control group. The epithelization time was significantly different between these two groups (P < 0.01).
  
  
  CONCLUSIONS
  The collagen can reduce infection and promote epithelization of mastoid cavity after mastoidectomy, which is clinically worthy to be applicated in mastoidectomy.
authors.affiliation: Department of Otolaryngology, People's Hospital of Peking University, Beijing, 100044, China. yxiaopei@yahoo.com.cn
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Yuan
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Lisheng
authors.initials: L
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D018424:Cholesteatoma, Middle Ear / Q000601:surgery*; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008297:Male; D008416:Mastoid / Q000601:surgery*; D008875:Middle Aged; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D003094:Collagen