Quality of life for women diagnosed with breast carcinoma in situ.
OBJECTIVE
Limited data exist on long-term quality of life (QOL) for women diagnosed with breast carcinoma in situ (BCIS).


METHODS
The data are on 795 BCIS participants diagnosed among female residents of Connecticut from September 15, 1994 to March 14, 1998, and 702 controls frequency-matched to the case participants by 5-year age intervals and geography. These women were participants in a large, population-based case/control study and subsequent follow-up study. Telephone interviews at follow-up were used to collect data on QOL at 5 years from initial diagnosis or contact, using the Medical Outcomes Study, Center for Epidemiologic Studies-Depression, and CAGE (Cut down, Annoyed, Guilty, Eye-opener) alcohol consumption scales. QOL outcomes were compared by case/control status and by case treatment group: lumpectomy, lumpectomy with adjuvant radiation therapy, and mastectomy.


RESULTS
At 5 years after diagnosis, women diagnosed with BCIS report levels of physical, emotional, and mental health functioning similar with those reported in a general healthy female population. Case participants and controls did not differ in reported levels of limitations due to physical health problems, bodily pain, social functioning, or overall physical functioning. Case participants who underwent lumpectomy with radiation reported lower levels of emotional functioning, general health perceptions, vitality, sexual interest, and overall mental health, as well as more depressive symptoms than did control subjects; although, the clinical significance of these statistical differences appears to be limited.


CONCLUSIONS
At 5 years after treatment, women diagnosed with BCIS report good physical and emotional functioning relative to control populations.
Claus
Elizabeth B
EB
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA. elizabeth.claus@yale.edu
Petruzella
Stacey
S
Carter
Darryl
D
Kasl
Stanislav
S
D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology / Q000523:psychology / Q000628:therapy; D002278:Carcinoma in Situ / Q000150:complications* / Q000473:pathology / Q000523:psychology / Q000628:therapy; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008603:Mental Health; D008875:Middle Aged; D011788:Quality of Life