title: Correlation between parameters of electrophysiological, histomorphometric and sciatic functional index evaluations after rat sciatic nerve repair.
abstract: The rat sciatic nerve is a well-established model for the study of recovery from peripheral nerve injuries. Traditional methods of assessing nerve regeneration after nerve injury and repair, such as electrophysiology and histomorphometry, despite widely used in neural regeneration experiments, do not necessarily correlate with return of motor and sensory functions. The aim of this experimental study is to investigate the possible correlation between several parameters of peripheral nerve regeneration after repair of sectioned sciatic nerve in Wistar rat. A two-stage approach was used to obtain 17 parameters after electrophysiological, morphometric and sciatic functional index evaluations. Pearson's correlation analysis was performed between these results. Only two positives correlations between different classes of peripheral nerve assessments were noted, between sciatic functional index and proximal nerve fiber diameter (r=0.56, p<0.01) and between sciatic functional index and distal fiber diameter (r=0.50, p<0.01). The data presented in our study demonstrates that there is a poor correlation between the sciatic functional index and outcome measures of electrophysiological and morphometric evaluations.
authors.affiliation: Peripheral Nerve Surgery Unit / LIM 45, Department of Neurosurgery, University of São Paulo Medical School, Rua Maestro Cardim 592/1101, 01323-001 São Paulo SP, Brazil. robar@ig.com.br
authors.forename: Roberto Sergio
authors.initials: RS
authors.lastname: Martins
authors.forename: Mario Gilberto
authors.initials: MG
authors.lastname: Siqueira
authors.forename: Ciro Ferreira
authors.initials: CF
authors.lastname: da Silva
authors.forename: José Píndaro Pereira
authors.initials: JP
authors.lastname: Plese
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004594:Electrophysiology; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D020426:Sciatic Neuropathy / Q000473:pathology / Q000503:physiopathology*