[Endothelial dysfunction and oxidative stress in sepsis].
Central to the pathophysiology of sepsis and septic shock is an alteration in endothelial cell function and oxidative stress. Highly complex, integrated responses that include the activation of a number of cell types, inflammatory mediators and the hemostatic system are involved in endothelial dysfunction. On the other hand, the imbalance between the excessive production of reactive oxygen species and/or inadequate antioxidative defenses characterizes the oxidative stress. The overview of all these mechanisms suggests clinical biochemical markers as a possible therapeutic target together with correct intervention timing.
Parodi
O
O
Istituto di Fisiologia Clinica del CNR, Milano. ifcnig@tin.it
De Chiara
B
B
Campolo
J
J
Sedda
V
V
Roubina
E
E
D015415:Biomarkers / Q000097:blood; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D018384:Oxidative Stress; D018805:Sepsis / Q000503:physiopathology* / Q000628:therapy
D015415:Biomarkers