The relation of adult bronchial responsiveness to serious childhood respiratory illness in the ECRHS.
BACKGROUND
Respiratory symptoms in adulthood have been found to be associated with childhood respiratory infection, but few studies have analyzed adult bronchial responsiveness (BHR) with adequate adjustment for known risk factors.


OBJECTIVE
To estimate the relation of BHR with serious childhood respiratory infections in a large population study.


METHODS
The European Community Respiratory Health Survey (ECRHS) was a cross-sectional population-based survey in 34 centers. Data on serious respiratory infections before the age of 5 years and possible confounders were obtained from a questionnaire administered in the clinic. Blood samples were taken for measurement of total immunoglobulin E (IgE) and specific IgE to four common allergens, and spirometry and bronchial challenge with methacholine were performed. A continuous measure of BHR was analyzed by multiple regression, in 11,282 participants, in relation to serious respiratory infection and other potential risk factors, adjusted for center and major determinants of adult BHR.


RESULTS
Those reporting a serious childhood respiratory infection had greater BHR, by an amount corresponding to approximately 0.23 doubling doses (95% confidence interval 0.02-0.44) of the amount of methacholine causing a 20% fall (PD(20)) in forced expiratory volume in 1s (FEV(1)). All childhood factors explained less than 0.3% of variation in BHR in addition to over 20% by factors measured in adulthood. The relation of BHR to BMI was confined to smokers.


CONCLUSIONS
We found an effect of serious childhood respiratory infection on adult BHR, but this was small in comparison to relations of BHR to IgE-sensitization and airway caliber.
Chinn
Susan
S
Department Public Health Sciences, King's College London, 5th floor Capital House, 42 Weston Street, London SE1 3QD, UK. s.chinn@imperial.ac.uk
Janson
Christer
C
Svanes
Cecilie
C
Dharmage
Shyamali
S
Jarvis
Deborah
D
D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D016535:Bronchial Hyperreactivity / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016085:Bronchoconstrictor Agents; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D016210:Methacholine Chloride; D012141:Respiratory Tract Infections / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014797:Vital Capacity
D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D007073:Immunoglobulin E