title: Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?
abstract: Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular perturbations caused by disease processes. Combination drug therapies with individualized optimization are likely to become a major focus. Metabolomics incorporates the most advanced approaches to molecular phenotype system readout and provides the ideal theranostic technology platform for the discovery of biomarker patterns associated with healthy and diseased states, for use in personalized health monitoring programs and for the design of individualized interventions.
authors.affiliation: TNO Systems Biology, Netherlands Organization for Applied Scientific Research, P.O. 360, 2700 AJ Zeist, Netherlands. jan.vandergreef@tno.nl
authors.forename: Jan
authors.initials: J
authors.lastname: van der Greef
authors.forename: Thomas
authors.initials: T
authors.lastname: Hankemeier
authors.forename: Robert N
authors.initials: RN
authors.lastname: McBurney
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000639:trends*; D006801:Humans; D008660:Metabolism / Q000235:genetics*; D012107:Research Design; D049490:Systems Biology / Q000639:trends*