title: [Prevalence of sensitization of Japanese cedar pollen in children from infancy to adolescence].
abstract: BACKGROUND
  In Japan, morbidity of Japanese cedar pollinosis has dramatically increased, especially in children. However, little is known about the prevalence of pollinosis and sensitization to Japanese cedar pollen (JCP) in young children.
  
  
  OBJECTIVE
  The aim of this study is to investigate the prevalence of sensitization to JCP in allergic and non-allergic children from infancy to adolescence.
  
  
  METHODS
  Two hundred forty three children with allergic diseases (age 8 months-16 years, mean 5 years) and 137 children without allergic diseases (age 1 month-15 years, mean 4 years) were recruited. Their specific IgE to JCP, house dust mite, orchard grass pollen, egg white, and milk were measured with the CAP-RAST system. A questionnaire was filled out by their parents.
  
  
  RESULTS
  The percentage of positive (> or = 2) CAP-RAST to JCP was 47.1% in children with allergic diseases and 19.9% in children without allergic diseases. In children with allergic diseases, the ratio had risen rapidly from 3 to 5 years old. In children without allergic diseases, the ratio of JCP sensitization has gradually increased from the infancy to adolescence. The youngest child who had been sensitized to JCP was 23-month-old boy with atopic dermatitis. The proportion of children who were born from January to march was significantly higher in JCP sensitized group than JCP non-sensitized group. The ratio of house dust mite and orchard grass pollen sensitization was higher in JCP sensitized group than those in JCP non-sensitized group.
  
  
  CONCLUSIONS
  Large number of children acquire sensitization to JCP in their preschool age. We need to develop the way how to protect JCP sensitization in the early stage of life.
authors.affiliation: Department of Otorhinolaryngology, National Mie Hospital. masudas@mie-m.hosp.go.jp
authors.forename: Sawako
authors.initials: S
authors.lastname: Masuda
authors.forename: Takao
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Kosei
authors.initials: K
authors.lastname: Iguchi
authors.forename: Jun
authors.initials: J
authors.lastname: Atsuta
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Noma
authors.forename: Mizuho
authors.initials: M
authors.lastname: Nagao
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Nambu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suehiro
authors.forename: Saori
authors.initials: S
authors.lastname: Kamesaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Terada
authors.forename: Mihoko
authors.initials: M
authors.lastname: Mizuno
authors.forename: Seiki
authors.initials: S
authors.lastname: Shimizu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tohda
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003233:Conjunctivitis, Allergic / Q000453:epidemiology / Q000276:immunology; D032485:Cryptomeria; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D011058:Pollen; D015995:Prevalence; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology* / Q000276:immunology; D012621:Seasons
chemical_list: D000485:Allergens