Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users.
The cellular basis for cognitive deficits in HIV+ patients with and without a history of methamphetamine (METH) use is unclear. We found that HIV+ METH users had more severe loss of interneurons that was associated with cognitive impairment. Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIV+ METH users.
Chana
G
G
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093-0624, USA.
Everall
I P
IP
Crews
L
L
Langford
D
D
Adame
A
A
Grant
I
I
Cherner
M
M
Lazzaretto
D
D
Heaton
R
R
Ellis
R
R
Masliah
E
E
D019969:Amphetamine-Related Disorders / Q000150:complications*; D002102:Cadaver; D003072:Cognition Disorders / Q000209:etiology* / Q000523:psychology; D005625:Frontal Lobe / Q000473:pathology; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D007395:Interneurons / Q000473:pathology*; D008569:Memory Disorders / Q000209:etiology; D008694:Methamphetamine; D009410:Nerve Degeneration / Q000150:complications / Q000209:etiology* / Q000473:pathology*; D012720:Severity of Illness Index
D008694:Methamphetamine