title: New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum.
abstract: Two new lanostanoids, 7-oxo-ganoderic acid Z (1) and 15-hydroxy-ganoderic acid S (2), were isolated from a lipophilic extract of the fruiting body of Ganoderma lucidum. The structures of both compounds were established by interpretation of their spectroscopic data. Compounds 1 and 2 both exhibited inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase.
authors.affiliation: Pharmanex Shanghai R&D, Building 11, Bi Po Rd, Shanghai 201203, China.
authors.forename: Canjun
authors.initials: C
authors.lastname: Li
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.forename: Hao H
authors.initials: HH
authors.lastname: Sun
mesh_terms: D000363:Agaricales / Q000378:metabolism*; D006538:Heptanoic Acids / Q000737:chemistry* / Q000378:metabolism*; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000378:metabolism*
chemical_list: C515758:15-hydroxy-ganoderic acid S; C515759:7-oxo-ganoderic acid Z; D006538:Heptanoic Acids; D014315:Triterpenes; D007810:Lanosterol