Dietary calcium supplementation suppresses bone formation in magnesium-deficient rats.
The purpose of this study was to clarify the effects of dietary calcium (Ca) supplementation on bone metabolism of magnesium (Mg)-deficient rats. Male Wistar rats were randomized by weight into three groups, and fed a control diet (control group), a Mg-deficient diet (Mg- group) or a Mg-deficient diet having twice the control Ca concentrations (Mg-2Ca group) for 14 days. Trabecular bone volume was significantly lower in the Mg- and Mg-2Ca groups than in the control group. Trabecular number was also significantly lower in the Mg- and Mg-2Ca groups than in the control group. Mineralizing bone surface, mineral apposition rate (MAR), and surface referent bone formation rate (BFR/BS) were significantly lower in the Mg- and Mg-2Ca groups than in the control group. Furthermore, MAR and BFR/BS were significantly lower in the Mg-2Ca group than in the Mg- group. These results suggest that dietary Ca supplementation suppresses bone formation in Mg-deficient rats.
Matsuzaki
Hiroshi
H
Department of Nutrition, Junior College of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. matsu@nodai.ac.jp
Miwa
Misao
M
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D001846:Bone Development / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004435:Eating; D005269:Femur / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008274:Magnesium / Q000008:administration & dosage / Q000378:metabolism; D008275:Magnesium Deficiency / Q000503:physiopathology*; D008297:Male; D010010:Osteoclasts / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D016226:Phosphorus, Dietary / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D050071:Bone Density Conservation Agents; D002136:Calcium, Dietary; D016226:Phosphorus, Dietary; D008274:Magnesium