High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules.
Detection of magnetically labeled biomolecules using micro-Hall biosensors is a promising method for monitoring biomolecular recognition processes. The measurement efficiency of standard systems is limited by the time taken for magnetic beads to reach the sensing area of the Hall devices. Here, micro-current lines were integrated with Hall effect structures to manipulate the position of magnetic beads via field gradients generated by localized currents flowing in the current lines. Beads were accumulated onto the sensor surface within seconds of passing currents through the current lines. Real-time detection of magnetic beads using current lines integrated with Hall biosensors was achieved. These results are promising in establishing Hall biosensor platforms as efficient and inexpensive means of monitoring biomolecular reactions for medical applications.
Sandhu
Adarsh
A
Quantum Nanoelectronics Research Center S-9-6, Tokyo Institute of Technology, 2-12-1 O-okayama, Tokyo 152-8552, Japan. sandhu@pe.titech.ac.jp
Kumagai
Yoshimichi
Y
Lapicki
Adam
A
Sakamoto
Satoshi
S
Abe
Masanori
M
Handa
Hiroshi
H
D015374:Biosensing Techniques; D004574:Electromagnetic Fields; D008280:Magnetics; D009841:Oligonucleotides / Q000032:analysis*; D013194:Staining and Labeling
D009841:Oligonucleotides