In vitro antianaerobic activity of DX-619, a new des-fluoro(6) quinolone.
The in vitro activity of DX-619, a new des-F(6) quinolone, against anaerobic bacteria was evaluated. DX-619 showed potent activity against Bacteroides, Prevotella, Fusobacterium, Micromonas, Actinomyces, and Clostridium spp., with MIC(50)s/MIC(90)s of </=0.03 to 0.25/</=0.03 to 1 microg/ml, respectively. DX-619 was also active against imipenem-resistant Bacteroides spp., with MIC(50)s/MIC(90)s of 0.25/1 microg/ml, respectively.
Tanaka
Kaori
K
Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. kktb@gifu-u.ac.jp
Mikamo
Hiroshige
H
Nakao
Ken'ichi
K
Watanabe
Kunitomo
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D005734:Gangrene / Q000382:microbiology; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011759:Pyrrolidines / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; C505440:DX 619; D011759:Pyrrolidines; D011804:Quinolines; D015363:Quinolones; D013845:Thienamycins; D015378:Imipenem