title: Immunophenotyping of amelanotic melanoma. A case report.
abstract: Amelanotic malignant melanoma (AMM) is a subtype of cutaneous melanoma with little or no pigment upon visual inspection. The lack of pigmentation is the reason for late diagnosis of lesions and a poor prognosis. We report a case of a 55-year-old female with an AMM diagnosed by immunophenotyping. Monoclonal antibodies S-100, HMB-45, and antibodies to cytokeratin were used. Our patient underwent a wide local excision (a 2 cm wide margin) 2 years ago. So far there are no signs of a recurrence. In doubtful cases, immunophenotyping with monoclonal antibodies HMB-45 and S-100 is important for confirming the correct diagnosis of AMM.
authors.affiliation: Clinic for Dermatovenerology, Nis Clinical Center, Bul. Zorana Djindjića 48, 18 000 Nis, Serbia.
authors.forename: Viktor
authors.initials: V
authors.lastname: Lazarević
authors.forename: Jelica
authors.initials: J
authors.lastname: Tiodorović
authors.forename: Danica
authors.initials: D
authors.lastname: Tiodorović-Zivković
authors.forename: Milenko
authors.initials: M
authors.lastname: Stanojević
authors.forename: Danijela
authors.initials: D
authors.lastname: Popović
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Janković
mesh_terms: D000906:Antibodies / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007633:Keratins / Q000276:immunology; D018328:Melanoma, Amelanotic / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009418:S100 Proteins / Q000276:immunology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; D009418:S100 Proteins; D007633:Keratins