Neutrophil infiltration and chemokines.
Neutrophil infiltration is mainly mediated by ELR+ CXC chemokines and is regulated through interactions between various stimulants and cells, which are perhaps more complex than previously thought. In this review, I describe the current view of the roles of neutrophil-selective chemokines such as IL-8, MIP-2, and KC by choosing several in vivo models. I also illustrate how these three chemokines are induced and how they are involved in neutrophil infiltration. Finally, I introduce synthetic compounds with high efficacy in the prevention of ischemia reperfusion injury.
Kobayashi
Yoshiro
Y
Division of Molecular Medicine, Department of Biomolecular Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. yoshiro@biomol.sci.toho-u.ac.jp
D000818:Animals; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000276:immunology*; D015427:Reperfusion Injury / Q000276:immunology / Q000517:prevention & control
D018925:Chemokines