[Effects of soy isoflavone on levels of low-grade inflammatory peptides in rats with insulin resistance].
OBJECTIVE
To explore the effects of soy isoflavone (SIF) on low-grade inflammation in rats with high-fat diet-induced insulin resistance (IR) and explore the mechanisms of SIF in improving insulin sensitivity.


METHODS
The rats with high-fat diet-induced IR were randomly divided into one model control group and 3 SIF groups gavaged with SIF water solutions at the doses of 50, 150, and 450 mg/kg, respectively. One month after the treatment, fasting blood glucose (FBG), fasting insulin (FINS), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), resistin and adiponectin in the serum were detected by enzymatic method, radioimmunoassay, or enzyme-linked immunosorbent assay.


RESULTS
In the 150 and 450 mg/kg SIF groups, fasting body-weights, visceral adipose tissue deposition, FINS, resistin, TNF-alpha in serum, and IR index were lowered in comparison with the model control group, and in 450 mg/kg SIF group, serum IL-6 level was obviously lowered, and adiponectin increased. No differences were found in serum C-reactive protein levels between the 3 SIF groups.


CONCLUSIONS
Soy isoflavone may ameliorate insulin sensitivity by decreasing visceral adipose deposition and adjusting low-grade inflammatory molecules derived from white adipose tissue.
Chen
Shi-wei
SW
Department of Nutrition and Food Hygiene, West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Li-shi
LS
Zhang
Hong-Min
HM
Feng
Xiao-fan
XF
D052242:Adiponectin / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002097:C-Reactive Protein / Q000378:metabolism*; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D050152:Intra-Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D052243:Resistin / Q000097:blood; D013025:Glycine max / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D052242:Adiponectin; D007328:Insulin; D015850:Interleukin-6; D007529:Isoflavones; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein