Systemic fungemia and hepatic localizations of Fusarium solani in a liver transplanted patient: an emerging fungal agent.
The incidence of invasive fungal infection is increasing especially in the field of transplantation, affecting as many as 50% of bone marrow transplant (BMT) patients with neutropenia and 5-20% of solid-organ transplant (SOT) recipients. Fusarium species are soil saprophytes and plant pathogens. They may cause superficial mycoses or important opportunistic infections in patients with bone marrow suppression and neutropenia, they have been rarely described in solid organ recipients, and up to now there have been no reports of such infection in isolated liver transplanted patients. We describe a case of disseminated Fusarium solani infection with hepatic localization in a liver transplanted patient that resolved with the administration of amphotericin B. Our observation confirms that Fusarium spp. are emerging pathogens that may most frequently affect not only BMT patients and patients with hematological malignancies, but also SOT patients. They may cause both localized and disseminated infection. In conclusion, Fusarium spp. etiology should be considered in the context of infectious diseases following liver transplantation.
Lodato
Francesca
F
Department of Internal Medicine and Gastroenterology, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Tamé
Maria Rosa
MR
Montagnani
Marco
M
Sambri
Vittorio
V
Liguori
Giovanna
G
Azzaroli
Francesco
F
Costigliola
Paolo
P
Grazi
Gianluca
G
Roda
Enrico
E
Mazzella
Giuseppe
G
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology*; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D008099:Liver / Q000382:microbiology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male
D000935:Antifungal Agents; D000666:Amphotericin B