title: Imparting size, shape, and composition control of materials for nanomedicine.
abstract: This tutorial review presents an overview of strategies for the synthesis and fabrication of organic nanomaterials, specifically those with potential for use in medical applications. Examples include liposomes, micelles, polymer-drug conjugates and dendrimers. Methods of driving shape via"bottom-up" synthetic approaches and thermodynamics and kinetics are discussed. Furthermore, methods of driving shape via"top-down" physical and engineering techniques are also explored. Finally, a novel method (referred to as PRINT) used to produce nanoparticles that are shape-specific, can contain any cargo, and can be easily modified is examined along with its potential future role in nanomedicine.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Larken E
authors.initials: LE
authors.lastname: Euliss
authors.forename: Julie A
authors.initials: JA
authors.lastname: DuPont
authors.forename: Stephanie
authors.initials: S
authors.lastname: Gratton
authors.forename: Joseph
authors.initials: J
authors.lastname: DeSimone
mesh_terms: D000818:Animals; D001698:Biomedical Engineering; D050997:Nanomedicine / Q000295:instrumentation*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D009930:Organic Chemicals / Q000737:chemistry; D010316:Particle Size
chemical_list: D009930:Organic Chemicals