title: Coagulopathy in two patients with cystic fibrosis treated with ciprofloxacin.
abstract: We report two cases of prolonged blood clotting times as demonstrated by a raised international normalised ratio and elevated activated partial thromboplastin time in patients with cystic fibrosis taking ciprofloxacin. The potential mechanisms of a coagulopathy of this picture as an adverse drug reaction with ciprofloxacin are discussed along with the possible clinical consequences for patients with cystic fibrosis.
authors.affiliation: Manchester Adult Cystic Fibrosis Unit, North West Lung Centre, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester, M23 9LT, UK. gillmoore@doctors.net.uk
authors.forename: Gillian C
authors.initials: GC
authors.lastname: Moore
authors.forename: Jan
authors.initials: J
authors.lastname: Redfern
authors.forename: Caroline R
authors.initials: CR
authors.lastname: Shiach
authors.forename: Kevin
authors.initials: K
authors.lastname: Webb
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001778:Blood Coagulation Disorders / Q000209:etiology*; D002939:Ciprofloxacin / Q000009:adverse effects*; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D010314:Partial Thromboplastin Time; D011552:Pseudomonas Infections / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin