Vertebrate head development: segmentation, novelties, and homology.
Vertebrate head development is a classical topic lately invigorated by methodological as well as conceptual advances. In contrast to the classical segmentalist views going back to idealistic morphology, the head is now seen not as simply an extension of the trunk, but as a structure patterned by different mechanisms and tissues. Whereas the trunk paraxial mesoderm imposes its segmental pattern on adjacent tissues such as the neural crest derivatives, in the head the neural crest cells carry pattern information needed for proper morphogenesis of mesodermal derivatives, such as the cranial muscles. Neural crest cells make connective tissue components which attach the muscle fiber to the skeletal elements. These crest cells take their origin from the same visceral arch as the muscle cells, even when the skeletal elements to which the muscle attaches are from another arch. The neural crest itself receives important patterning influences from the pharyngeal endoderm. The origin of jaws can be seen as an exaptation in which a heterotopic shift of the expression domains of regulatory genes was a necessary step that enabled this key innovation. The jaws are patterned by Dlx genes expressed in a nested pattern along the proximo-distal axis, analogous to the anterior-posterior specification governed by Hox genes. Knocking out Dlx 5 and 6 transforms the lower jaw homeotically into an upper jaw. New data indicate that both upper and lower jaw cartilages are derived from one, common anlage traditionally labelled the "mandibular" condensation, and that the "maxillary" condensation gives rise to other structures such as the trabecula. We propose that the main contribution from evolutionary developmental biology to solving homology questions lies in deepening our biological understanding of characters and character states.
Olsson
Lennart
L
Institut für Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, Friedrich-Schiller-Universität, D-07743 Jena, Germany. Lennart.Olsson@uni-jena.de
Ericsson
Rolf
R
Cerny
Robert
R
D000818:Animals; D005075:Biological Evolution; D006257:Head / Q000033:anatomy & histology* / Q000196:embryology*; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D009132:Muscles / Q000196:embryology; D009432:Neural Crest / Q000196:embryology; D012886:Skull / Q000033:anatomy & histology / Q000196:embryology; D014157:Transcription Factors / Q000235:genetics; D014714:Vertebrates / Q000196:embryology*; D015046:Zoology
C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors