title: Hexosaminidase as a new potential marker for middle ear cholesteatoma.
abstract: OBJECTIVE
  The study aim was to investigate the activities of hexosaminidase (HEX) in cholesteatoma tissue compared with that in normal skin.
  
  
  METHODS
  The enzyme activities were determined using the Chatterjee et al. method in the modification of Zwierz et al. in cholesteatoma and skin.
  
  
  RESULTS
  Significantly higher activity of hexosaminidase was observed in cholesteatoma tissue compared with the skin.
  
  
  CONCLUSIONS
  Hex may be considered as a new pathogenetic factor in that destructive lesion.
authors.affiliation: Department of Otolaryngology, Medical University, ul. Sklodowskiej 24 A, 15-274 Bialystok, Poland. ewaolsz@yahoo.com <ewaolsz@yahoo.com>
authors.forename: Ewa
authors.initials: E
authors.lastname: Olszewska
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Borzym-Kluczyk
authors.forename: Slawomir
authors.initials: S
authors.lastname: Olszewski
authors.forename: Marek
authors.initials: M
authors.lastname: Rogowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwierz
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D018424:Cholesteatoma, Middle Ear / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D006596:Hexosaminidases