Adhere upright: a switchblade-like extension of beta2 integrins.
In this issue of Immunity, demonstrate a spectrum of dynamic conformation changes, from a bent form to extended forms, in extracellular domains in alpha(X)beta(2) and alpha(L)beta(2) upon separation of the alpha and beta subunits, providing structural evidence for activation of leukocyte integrins.
Kinashi
Tatsuo
T
Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.
D006801:Humans; D016167:Integrin alphaXbeta2 / Q000737:chemistry*; D007962:Leukocytes / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000737:chemistry*; D011487:Protein Conformation; D017510:Protein Folding
D016167:Integrin alphaXbeta2; D016169:Lymphocyte Function-Associated Antigen-1