Metabolic reprogramming in dietary restriction.
It is widely accepted that energy intake restriction without essential nutrient deficiency delays the onset of aging and extends life span. The mechanism underlying this phenomenon is still unknown though a number of different, nonmutually exclusive explanations have been proposed. In each of these, different facets of physiology play the more significant role in the mechanism of aging retardation. Some examples include the altered lipid composition model, the immune response model and models describing changes in endocrine function. In this paper we propose the hypothesis that metabolic reprogramming is the key event in the mechanism of dietary restriction, and the physiological effects at the cellular, tissue and organismal level may be understood in terms of this initial event.
Anderson
Rozalyn M
RM
Department of Medicine, University of Wisconsin, and VA Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA. rmanderson5@wisc.edu
Weindruch
Richard
R
D000273:Adipose Tissue; D000375:Aging / Q000378:metabolism* / Q000502:physiology; D031204:Caloric Restriction; D002149:Energy Intake / Q000502:physiology; D006801:Humans; D008017:Life Expectancy; D008136:Longevity; D008928:Mitochondria / Q000201:enzymology; D018384:Oxidative Stress