title: Activity of tigecycline against clinical isolates of Staphylococcus aureus and extended-spectrum beta-lactamase-producing Escherichia coli in Granada, Spain.
abstract: We evaluated the in vitro activity of tigecycline using the Etest and disk diffusion method according to Clinical and Laboratory Standards Institute guidelines against clinical isolates of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) as well as for CTX-M-9 extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and SHV ESBL-producing E. coli. All isolates were susceptible to tigecycline according to US Food and Drug Administration cut-off points. There were no differences in the activity of tigecycline between MSSA and MRSA isolates or between the presence of either type of ESBL. For each type of microorganism studied, we established the equation relating the minimum inhibitory concentration to the diameter of the zone of inhibition.
authors.affiliation: Department of Microbiology, University of Granada, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Sorlózano
authors.forename: J
authors.initials: J
authors.lastname: Gutiérrez
authors.forename: A
authors.initials: A
authors.lastname: Salmerón
authors.forename: J D
authors.initials: JD
authors.lastname: Luna
authors.forename: F
authors.initials: F
authors.lastname: Martínez-Checa
authors.forename: J
authors.initials: J
authors.lastname: Román
authors.forename: G
authors.initials: G
authors.lastname: Piédrola
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology; D029968:Escherichia coli Proteins / Q000096:biosynthesis*; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D000078304:Tigecycline; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D000078304:Tigecycline; C412613:CTX-M-9 protein, E coli; D001618:beta-Lactamases; D008911:Minocycline; D008712:Methicillin