Differentiation between the sensory and affective aspects of histamine-induced bronchoconstriction in asthma.
Respiratory symptom perception research has focused mainly on respiratory sensations. Because dyspnea is multidimensional, affective aspects should be investigated. Patients with asthma (N=25) underwent a histamine provocation until a 20% fall in forced expiratory volume in 1s (FEV(1)). After each dose level, 6 symptoms of dyspnea intensity and 6 symptoms of dyspnea affectivity were rated. Individual perceptual sensitivity was determined by calculating the linear slope between the fall in FEV(1) and the increase in the total symptom score, and for affective and sensory symptoms separately [Bijl-Hofland, Folgering, van den Hoogen, et al. Perception of bronchoconstriction in asthma patients measured during histamine challenge test. Eur Respir J 1999;14:1049-54]. Trait anxiety, baseline state anxiety, daily asthma symptoms and catastrophizing during an asthma exacerbation were also assessed. Sensitivity was unrelated to physiological indices of disease severity (i.e., baseline FEV(1) and histamine dose level at 20% fall in FEV(1)), whereas it was positively related to trait anxiety, state anxiety, daily asthma symptoms and catastrophic thinking during an asthma exacerbation in daily life. These relationships were overall much stronger for affective than for sensory symptom slopes. In stepwise multiple regressions, state anxiety was the best predictor of the affective symptom slopes, whereas catastrophic thinking during an asthma exacerbation was the best predictor for the sensory symptom slopes. The differentiation between sensory and affective components of dyspnea adds to the understanding of respiratory symptom perception in asthma.
De Peuter
Steven
S
Research Group for Stress, Health & Well-Being, Psychology Department, University of Leuven, Tiensestraat 102, B-3000 Leuven, Belgium. steven.depeuter@psy.kuleuven.be
Lemaigre
Valentine
V
Van Diest
Ilse
I
Verleden
Geert
G
Demedts
Maurits
M
Van den Bergh
Omer
O
D000293:Adolescent; D000328:Adult; D000339:Affect; D000368:Aged; D001007:Anxiety / Q000523:psychology; D001249:Asthma / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D001294:Attitude to Health; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction; D004417:Dyspnea / Q000209:etiology / Q000523:psychology*; D005260:Female; D005541:Forced Expiratory Volume; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D012677:Sensation
D006632:Histamine