title: Comparative genomic hybridization by microarray for the detection of cytogenetic imbalance.
abstract: Chromosomal abnormalities often result in the improper dosage of genes in a particular chromosome or chromosome segment, which may cause specific and complex clinical phenotypes. Comparative genomic hybridization by microarray (array CGH) is a high-throughput and high-resolution method for the detection of microscopic and submicroscopic chromosome abnormalities, some of which may not be detectable by conventional cytogenetic techniques. In addition, with the human genome sequenced and publicly available, array CGH allows for the direct correlation between chromosomal anomalies and genomic sequence. Properly constructed, microarrays have the potential to be a valuable tool for the detection of chromosomal abnormalities in cancer and genetic disease.
authors.affiliation: Health Research and Education Center, Washington State University, Spokane, WA, USA.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Jarmuz
authors.forename: Blake C
authors.initials: BC
authors.lastname: Ballif
authors.forename: Catherine D
authors.initials: CD
authors.lastname: Kashork
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Theisen
authors.forename: Bassem A
authors.initials: BA
authors.lastname: Bejjani
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Shaffer
mesh_terms: D002460:Cell Line; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000235:genetics; D020732:Cytogenetic Analysis / Q000379:methods; D005260:Female; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D007621:Karyotyping / Q000379:methods; D008297:Male; D009693:Nucleic Acid Hybridization / Q000379:methods*; D010641:Phenotype