title: Extradural motor cortex stimulation as a method to treat advanced Parkinson's disease: new perspectives in geriatric medicine.
abstract: Motor fluctuations not controlled by pharmacological therapy are often encountered in long-term Parkinson's disease (PD). Neurosurgery treatment represented by deep brain stimulation (DBS) was considered a valid alternative to pharmacological treatment. Unfortunately this method is most effective in patients under age of 70. Recently it has been suggested that extradural motor cortex stimulation (EMCS) could be a valid cost-effective alternative to DBS to control motor symptoms in patients affected by Parkinson's disease. The relevant non-invasive surgical technique makes this treatment particularly indicated in geriatric patients. Brain atrophy, cognitive impairment, psychiatric symptoms are not an absolute contraindication to the treatment. We submitted to EMCS an outpatient afferent to our geriatric department, a woman 68 yrs old. The patient showed an improvement of 35% as measured by the Unified Parkinson Disease Rating Scale (UPDRS) scale after the surgery. If our findings will be confirmed in larger series, a new dimension will be added to the treatment of PD.
authors.forename: E
authors.initials: E
authors.lastname: Benvenuti
authors.forename: F
authors.initials: F
authors.lastname: Cecchi
authors.forename: A
authors.initials: A
authors.lastname: Colombini
authors.forename: G
authors.initials: G
authors.lastname: Gori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods*; D005853:Geriatrics / Q000379:methods; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects / Q000379:methods; D009044:Motor Cortex / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome