Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima.
Two new cyclic heptapeptides, integerrimides A and B, have been isolated from the latex of Jatropha integerrima. Their structures were elucidated by using extensive 1D and 2D NMR, MS, and chemical degradation. At 50 microM both peptides 1 and 2 significantly inhibited neurite outgrowth in neuronal cell culture. They also partially inhibited proliferation of human IPC-298 melanoma cells as well as migration of human Capan II pancreatic carcinoma cells, but were inactive in HSV-1, antifungal, and antimalarial assays.
Mongkolvisut
Wantana
W
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
Sutthivaiyakit
Somyote
S
Leutbecher
Heiko
H
Mika
Sabine
S
Klaiber
Iris
I
Möller
Wolfgang
W
Rösner
Harald
H
Beifuss
Uwe
U
Conrad
Jürgen
J
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002645:Chickens; D004354:Drug Screening Assays, Antitumor; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D031286:Jatropha / Q000737:chemistry*; D007840:Latex / Q000737:chemistry; D015394:Molecular Structure; D016501:Neurites / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects; D013785:Thailand
D000972:Antineoplastic Agents, Phytogenic; D007840:Latex; D010456:Peptides, Cyclic; C515180:integerrimide A; C515181:integerrimide B