Absence of Toll-like receptor 4 signaling results in delayed Yersinia enterocolitica YopP-induced cell death of dendritic cells.
In an initial period (< or =4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (>4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates caspase 8 activation, leading to DC death.
Gröbner
Sabine
S
Institute of Medical Microbiology and Hygiene, Eberhard Karls University of Tübingen, Elfriede-Aulhorn-Str. 6, D-72076 Tübingen, Germany. sabine.groebner@med.uni-tuebingen.de
Schulz
Sebastian
S
Soldanova
Irena
I
Gunst
Dani S J
DS
Waibel
Michaela
M
Wesselborg
Sebastian
S
Borgmann
Stefan
S
Autenrieth
Ingo B
IB
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001426:Bacterial Proteins / Q000276:immunology*; D053181:Caspase 8 / Q000378:metabolism; D003713:Dendritic Cells / Q000382:microbiology* / Q000473:pathology; D004789:Enzyme Activation / Q000276:immunology; D015151:Immunoblotting; D051379:Mice; D015398:Signal Transduction / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000276:immunology
D001426:Bacterial Proteins; D051197:Toll-Like Receptor 4; C109227:YopP protein, Yersinia; D053181:Caspase 8