Cardiovascular polycystins: insights from autosomal dominant polycystic kidney disease and transgenic animal models.
Mutations in the PKD1 and PKD2 polycystin genes are responsible for autosomal dominant polycystic kidney disease (ADPKD), one of the most prevalent genetic kidney disorders. ADPKD is a multisystem disease characterized by the formation of numerous fluid-filled cysts in the kidneys, the pancreas, and the liver. Moreover, major cardiovascular manifestations are common complications in ADPKD. Intracranial aneurysms and arterial hypertension are among the leading causes of mortality in this disease. In the present review, we summarize our current understanding of the role of polycystins in the development, maintenance, and function of the cardiovascular system.
Bichet
Delphine
D
Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France.
Peters
Dorien
D
Patel
Amanda Jane
AJ
Delmas
Patrick
P
Honoré
Eric
E
D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D016891:Polycystic Kidney, Autosomal Dominant / Q000209:etiology*; D050396:TRPP Cation Channels
D050396:TRPP Cation Channels