title: Using recombinant platelet-derived growth factor to facilitate wound healing.
abstract: Recombinant human platelet-derived growth factor (rhPDGF-BB) is a bioactive protein that has been combined with bone graft materials in an effort to regenerate the periodontium to its prediseased state more predictably. The combination of a biocompatible scaffold with this highly purified, recombinant human growth factor capitalizes on PDGF's stimulatory effects on cellular migration and proliferation, with subsequent matrix formation, to drive the healing process toward regeneration. When using a growth factor such as rhPDGF-BB with broad wound healing activity, an added clinical benefit is the more rapid soft tissue wound healing pattern observed at the surgical site. This also may be seen as a patient-centered benefit because it allows dentists to provide for a patient's prosthetic care on a timely basis, leading to a faster return to normal function. Also, the patient may resume plaque control efforts earlier, which further facilitates the wound-healing process. The purpose of these 2 case reports is to document the use of rhPDGF-BB as a wound-healing agent in 2 clinical situations and to provide a rationale for its use in this capacity.
authors.affiliation: Department of Periodontics, Baltimore College of Dental Surgery, University of Maryland, Baltimore, Maryland, USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Rosen
mesh_terms: D000368:Aged; D000539:Alveolar Process / Q000187:drug effects; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D003094:Collagen; D016556:Crown Lengthening; D015921:Dental Implants; D004337:Drug Carriers; D006801:Humans; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000601:surgery*; D008875:Middle Aged; D010027:Osteotomy; D010513:Periodontal Ligament / Q000187:drug effects; D010519:Periodontium / Q000187:drug effects / Q000601:surgery*; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D013524:Surgical Flaps; D020390:Tooth Socket / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects
chemical_list: D043925:Angiogenesis Inducing Agents; D015921:Dental Implants; D004337:Drug Carriers; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin; D003094:Collagen