title: Low daytime pulse oximetry reading is associated with nocturnal desaturation and obstructive sleep apnea in children with sickle cell anemia.
abstract: A retrospective medical record review was established to test the hypothesis that in children with sickle cell anemia (SCA), a daytime oxygen saturation (SpO(2)) </=94% is associated with nocturnal desaturation with or without obstructive sleep apnea (OSA). Twenty children had a resting SpO(2) </=94% and an abnormal polysomnogram (PSG). Seven patients had OSA and thirteen patients had nocturnal desaturation. The average daytime SpO(2) correlated with the average nighttime SpO(2) (Spearman correlation coefficient = 0.453; P = 0.045). Our results indicate that in children with SCA, a daytime SpO(2) </=94% is a reasonable threshold to recommend a pulmonary evaluation, including a PSG.
authors.affiliation: Department of Pediatrics, Washington University School of Medicine/St. Louis Children's Hospital, St. Louis, Missouri, USA.
authors.forename: John F
authors.initials: JF
authors.lastname: Spivey
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Uong
authors.forename: Robert
authors.initials: R
authors.lastname: Strunk
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Boslaugh
authors.forename: Michael R
authors.initials: MR
authors.lastname: DeBaun
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000097:blood*
chemical_list: D010100:Oxygen