Combining functional and linkage disequilibrium information in the selection of tag SNPs.
We have developed an online program, WCLUSTAG, for tag SNP selection that allows the user to specify variable tagging thresholds for different SNPs. Tag SNPs are selected such that a SNP with user-specified tagging threshold C will have a minimum R2 of C with at least one tag SNP. This flexible feature is useful for researchers who wish to prioritize genomic regions or SNPs in an association study.


BACKGROUND
The online WCLUSTAG program is available at http://bioinfo.hku.hk/wclustag/
Sham
P C
PC
Department of Psychiatry, Institute of Psychiatry, King's College London, UK.
Ao
S I
SI
Kwan
J S H
JS
Kao
P
P
Cheung
F
F
Fong
P Y
PY
Ng
M K
MK
D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods; D016000:Cluster Analysis; D005819:Genetic Markers; D020407:Internet; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016324:Sequence Tagged Sites; D012984:Software; D014584:User-Computer Interface
D005819:Genetic Markers