title: Respiratory variations in pulse oximeter waveform amplitude are influenced by venous return in mechanically ventilated patients under general anaesthesia.
abstract: OBJECTIVE
  Respiratory variations in pulse oximetry plethysmographic waveform amplitude (DeltaPOP) are related to respiratory variations in arterial pulse pressure (DeltaPP) in the critical care setting. The aims of this study were to test the hypothesis that in mechanically ventilated patients undergoing general anaesthesia, DeltaPOP calculation is feasible and can detect changes in preload.
  
  
  METHODS
  Twenty-five mechanically ventilated patients were studied immediately after induction of general anaesthesia. Haemodynamic data (mean arterial pressure [MAP], central venous pressure [CVP], DeltaPP and DeltaPOP) were recorded at baseline, before and after tilting the patient from anti-Trendelenburg to Trendelenburg position in order to induce preload changes.
  
  
  RESULTS
  Change from anti-Trendelenburg to Trendelenburg position induced changes in MAP (58 +/- 9 to 67 +/- 10 mmHg, P < 0.05), CVP (4 +/- 4 to 13 +/- 5 mmHg, P < 0.05), DeltaPP (14 +/- 8 to 7 +/- 5%, P < 0.05) and DeltaPOP (17 +/- 12 to 9 +/- 5%, P < 0.05). There was a significant relationship between DeltaPOP in anti-Trendelenburg position and percent change in MAP after volume expansion (r = 0.82; P < 0.05).
  
  
  CONCLUSIONS
  DeltaPOP can be determined in the operating room and is influenced by changes in preload. This new index has potential clinical applications for the prediction of fluid responsiveness.
authors.affiliation: Claude Bernard Lyon 1 University, Louis Pradel Hospital, Department of Anaesthesiology and Intensive Care, EA 1896, France. maxime_cannesson@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Cannesson
authors.forename: O
authors.initials: O
authors.lastname: Desebbe
authors.forename: M
authors.initials: M
authors.lastname: Hachemi
authors.forename: D
authors.initials: D
authors.lastname: Jacques
authors.forename: O
authors.initials: O
authors.lastname: Bastien
authors.forename: J-J
authors.initials: JJ
authors.lastname: Lehot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000768:Anesthesia, General / Q000379:methods*; D001794:Blood Pressure / Q000502:physiology; D002496:Central Venous Pressure / Q000502:physiology*; D005240:Feasibility Studies; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D010092:Oximetry / Q000379:methods*; D010991:Plethysmography / Q000379:methods; D011187:Posture; D012119:Respiration; D012121:Respiration, Artificial / Q000379:methods*; D018667:Tilt-Table Test