Prevalence of dyslipidemia in non-obese prepubertal children and its association with family history of diabetes, high blood pressure, and obesity.
BACKGROUND
Because obesity masks the need for screening, there is no previous description of dyslipidemia in healthy normal-weight children. The aims of this study were a) to determine the prevalence of disorders in lipid profile among non-obese prepubertal children, and b) to establish its association with the family history (FH) of high blood pressure (HBP), type 2 diabetes (T2-DM), and obesity.


METHODS
A random sample of 439 healthy normal-weight children, 218 girls and 221 boys, aged 10-13 years and Tanner stage 1-2 were enrolled in a community-based cross-sectional study carried out in Durango, in northern Mexico. For verifying accuracy of FH, a direct detailed medical history including anthropometric and laboratory measurements was directly obtained from both parents.


RESULTS
Among parents, prevalence (95% CI) of T2-DM, HBP, and obesity was 8.3% (3.5-14.3), 14.2% (8.6-24.6), and 28.5% (24-33), and for hypercholesterolemia, low HDL-cholesterol, high LDL-cholesterol, hypertriglyceridemia, and mixed hyperlipidemia 17.9 % (15-20), 27.8% (25-30), 14.3% (12-16), 32.3% (29-35), and 9.8 % (8-12), respectively. Among children, prevalence (95% CI) for high total cholesterol, low HDL-cholesterol, high LDL-cholesterol, isolated hypertriglyceridemia, and mixed hyperlipidemia was 15.9% (12.6-19.5); 6.2% (4.0-8.5); 14.6% (11.4-18.0); 9.3% (6.7-12.2); and 3.6% (2.1-5.8), respectively. Sex- and birth weight-adjusted odds ratio (95% CI) showed that FH of T2-DM, but not of HBP and obesity, was associated with hypercholesterolemia (2.1; 1.2-6.2), low HDL-cholesterol (1.8; 1.1-5.7), and hypertriglyceridemia (2.3; 1.1-6.4).


CONCLUSIONS
Non-obese children in this sample display a high prevalence of abnormalities in lipid profile associated with FH of T2-DM.
Guerrero-Romero
Fernando
F
Medical Research Unit in Clinical Epidemiology of the Mexican Social Security Institute, Durango, Mexico, and Research Group on Diabetes and Chronic Illnesses, Durango, Mexico. guerrero_romero@hotmail.com <guerrero_romero@hotmail.com>
Rodríguez-Morán
Martha
M
D000293:Adolescent; D001724:Birth Weight; D015992:Body Mass Index; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D050171:Dyslipidemias / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008055:Lipids / Q000097:blood*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009765:Obesity / Q000235:genetics; D010375:Pedigree; D015995:Prevalence
D008055:Lipids