title: [Research advances in ecotoxicology and risk assessment of chemical mixtures at low doses].
abstract: Chemicals in the environment often exist as mixtures and at low doses, whose ecotoxicological diagnosis and risk assessment are hard to be done with the help of the research results on the ecotoxicity of high-level exposure of single chemicals. This paper reviewed the research advances in ecotoxicology and risk assessment of low-dose chemical mixture contamination, with the focus on the molecular toxicological methods and the risk assessment approaches and schemes of simple and complex mixtures. Comments were given on the development directions of low-dose chemical mixture research, including the necessity of searching for sensitive endpoints, involving the approaches of other disciplines, increasing data accumulation, and setting up a comprehensive and identical risk assessment system.
authors.affiliation: Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. lixinxin@mails.gscas.ac.cn
authors.forename: Xinxin
authors.initials: X
authors.lastname: Li
authors.forename: Yufang
authors.initials: Y
authors.lastname: Song
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Daoli
authors.initials: D
authors.lastname: Yang
authors.forename: Qixing
authors.initials: Q
authors.lastname: Zhou
authors.forename: Tieheng
authors.initials: T
authors.lastname: Sun
mesh_terms: D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000032:analysis*; D006801:Humans; D018570:Risk Assessment
chemical_list: D004785:Environmental Pollutants