title: Isolated splenic vein thrombosis secondary to splenic metastasis: a case report.
abstract: A 49-year-old, previously healthy woman sought treatment for abdominal pain. Colonoscopy revealed ascending colon cancer. Computed tomography and angiography showed splenic metastasis and thrombosis extending from the splenic vein to the portal vein. She underwent right hemicolectomy, splenectomy, and distal pancreatomy. Histological findings showed no malignant cell in the splenic vein which was filled with organizing thrombus. We postulate the mechanism of splenic vein thrombosis in our case to be secondary to the extrinsic compression of the splenic vein by the splenic metastasis or by the inflammatory process produced by the splenic metastasis. In conclusion, we suggest that splenic metastasis should be added to the list of differential diagnosis which causes splenic vein thrombosis. In the absence of other sites of neoplastic disease, splenectomy seems to be the preferred therapy because it can be performed with low morbidity and harbors the potential for long-term survival.
authors.affiliation: Department of Surgery, Hamamatsu Red Cross Hospital, 1-5-30 Takabayashi, Hamamatsu, Shizuoka 430-0907, Japan. hiraiwa9215@hotmail.com
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hiraiwa
authors.forename: Kyoei
authors.initials: K
authors.lastname: Morozumi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sotome
authors.forename: Akio
authors.initials: A
authors.lastname: Furukawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamaru
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Hisami
authors.initials: H
authors.lastname: Iri
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000556:secondary*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000473:pathology; D013160:Splenic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000556:secondary*; D013162:Splenic Vein / Q000473:pathology*; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology