title: Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty.
abstract: We report a long-term study of bioactive bone cement (BABC) in a canine total hip arthroplasty (THA) at follow-up of 8 years. Previous studies have shown excellent biomechanical and histological results at follow-up of 6, 12, and 24 months. In the present study, THA was performed in a beagle dog using BABC consisting of an apatite- and wollastonite-containing glass ceramic (AW-GC) powder and SiO2 powder as the filler and a bisphenol-a-glycidyl methacrylate (Bis-GMA) based resin as the organic matrix. Histological examination showed direct bonding between BABC and bone without any intervening soft tissue layer at the BABC-bone interface. A reactive layer, through which BABC bonded to the bone, was observed thicker at 8 years than it was at 24 weeks. No adverse effects of BABC were observed. BABC maintained the high bioactivity and direct bonding to bone in a canine THA at follow-up of 8 years.
authors.affiliation: Department of Orthopaedic Surgery, Kyoto University, Japan.
authors.forename: Bojian
authors.initials: B
authors.lastname: Liang
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujibayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujita
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ise
authors.forename: Masashi
authors.initials: M
authors.lastname: Neo
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001031:Apatites; D019644:Arthroplasty, Replacement, Hip; D001672:Biocompatible Materials; D017438:Bisphenol A-Glycidyl Methacrylate; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use*; D002484:Cementation; D002516:Ceramics; D004285:Dogs; D005269:Femur / Q000000981:diagnostic imaging / Q000648:ultrastructure; D005500:Follow-Up Studies; D008855:Microscopy, Electron, Scanning; D011859:Radiography; D012824:Silicic Acid
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D001843:Bone Cements; C077777:apatite-wollastonite-containing glass ceramic; D012824:Silicic Acid; D017438:Bisphenol A-Glycidyl Methacrylate