title: Treatment of mediastinal immature teratoma in a child with precocious puberty and Klinefelter's syndrome.
abstract: Teratoma is the most common germ cell tumor, which can be divided into the mature and the immature histologically. Concurrent Klinefelter's syndrome may be overlooked in a patient with a germ cell tumor. This is because the tumor that secrets alpha-fetoprotein and beta human chorionic gonadotropin can mimic puberty in a patient with Klinefelter's syndrome, masking the usual clinical signs. In reviewing the literature on the subject, the role of neoadjuvant and adjuvant chemotherapy remains ill-defined for the immature teratoma. Age-dependent prognosis seems to demonstrate that children with immature teratomas have a better outcome. We share the experience of treating a child with immature teratoma with surgical excision alone, and it ended in a local recurrence.
authors.affiliation: Department of Surgery, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan.
authors.forename: Chen-Kun
authors.initials: CK
authors.lastname: Chen
authors.forename: Yih-Leong
authors.initials: YL
authors.lastname: Chang
authors.forename: Shiann-Tarng
authors.initials: ST
authors.lastname: Jou
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Tseng
authors.forename: Yung-Chie
authors.initials: YC
authors.lastname: Lee
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D002675:Child, Preschool; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D009364:Neoplasm Recurrence, Local; D011629:Puberty, Precocious / Q000209:etiology; D012086:Reoperation; D013724:Teratoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin