Taxane-resistant lymphoepithelial-like carcinoma: excellent response to VIP chemotherapy.
BACKGROUND
Lymphoepithelial-like carcinoma is a rare tumour type. The optimal treatment for this disease is not known. No effective therapies are described in the literature.


OBJECTIVE
This report describes a case of lymphoepithelial-like carcinoma and documents a therapeutic strategy which has proved effective.


RESULTS
The patient was initially treated with a common platinum-based chemotherapy regimen incorporating a taxane (Carbplatin and Docetaxel). Disease stabilization initially occurred but the patient soon progressed. The patient was then treated with VIP chemotherapy and had a complete response.


CONCLUSIONS
VIP chemotherapy appears to be an effective therapeutic strategy in lymphoepithelial-like carcinoma.
Duffy
A G
AG
Dept of Medical Oncology, Mercy University Hospital, Cork. austinduffy@hotmail.com
Wyse
G
G
Horgan
A M
AM
O'Keefe
M
M
O'Reilly
S
S
Breathnach
O S
OS
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D008297:Male; D019042:Muscle Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011034:Podophyllotoxin / Q000627:therapeutic use; D016658:Psoas Muscles; D011859:Radiography; D043823:Taxoids / Q000627:therapeutic use*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane; D011034:Podophyllotoxin; D002945:Cisplatin; D007069:Ifosfamide