title: [Incretins].
abstract: Insulin secretion is greater after peroral challenge than after intravenous glucose administration due to so-called incretin effect. The major incretins are glucagon-like peptide 1 and glucose-dependent-insulinotropic peptide. Physiology, pathophysiology and therapeutic implications of incretins in diabetes, neurodegenerative disorders and stress-induced hyperglycemia are concerned.
authors.affiliation: Endokrinologický ustav, Praha. jvrbikova@endo.cz
authors.forename: J
authors.initials: J
authors.lastname: Vrbíková
authors.forename: K
authors.initials: K
authors.lastname: Vondra
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D005749:Gastric Inhibitory Polypeptide / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000502:physiology*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology / Q000628:therapy; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion
chemical_list: D007328:Insulin; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1