title: Molecular characterization of human adenoviruses isolated in Italy.
abstract: There is little information on the epidemiology of Human Adenoviruses (HAdVs) in Italy. In this study, 103 HAdV isolates, collected by the A. Gemelli Hospital (Catholic University Medical School of Rome, Italy) between 1987 and 2005, were genotyped by sequencing and phylogenetic analysis on a partial hexon gene region. Nine different serotypes belonging to all six HAdV species were identified. Serotype 2 was the most frequent (53.4%), followed by serotype 1 (15.53%) and serotype 41 (9.7%). Partial-hexon-based identification was confirmed as an effective tool for studying the molecular epidemiology of HAdVs.
authors.affiliation: Istituto Superiore di Sanità, Dipartimento Ambiente e Connessa Prevenzione Primaria, Roma, Italy. giuseppina.larosa@iss.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: La Rosa
authors.forename: Michele
authors.initials: M
authors.lastname: Muscillo
authors.forename: Marcello
authors.initials: M
authors.lastname: Iaconelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Grazia
authors.forename: Stefano
authors.initials: S
authors.lastname: Fontana
authors.forename: Michela
authors.initials: M
authors.lastname: Sali
authors.forename: Elena
authors.initials: E
authors.lastname: De Carolis
authors.forename: Paola
authors.initials: P
authors.lastname: Cattani
authors.forename: Stefania
authors.initials: S
authors.lastname: Manzara
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fadda
mesh_terms: D000258:Adenovirus Infections, Human / Q000453:epidemiology / Q000821:virology*; D000260:Adenoviruses, Human / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012703:Serotyping
chemical_list: D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus