Impact of intra-arterial administration of boron compounds on dose-volume histograms in boron neutron capture therapy for recurrent head-and-neck tumors.
OBJECTIVE
To analyze the dose-volume histogram (DVH) of head-and-neck tumors treated with boron neutron capture therapy (BNCT) and to determine the advantage of the intra-arterial (IA) route over the intravenous (IV) route as a drug delivery system for BNCT.


METHODS
Fifteen BNCTs for 12 patients with recurrent head-and-neck tumors were included in the present study. Eight irradiations were done after IV administration of boronophenylalanine and seven after IA administration. The maximal, mean, and minimal doses given to the gross tumor volume were assessed using a BNCT planning system.


RESULTS
The results are reported as median values with the interquartile range. In the IA group, the maximal, mean, and minimal dose given to the gross tumor volume was 68.7 Gy-Eq (range, 38.8-79.9), 45.0 Gy-Eq (range, 25.1-51.0), and 13.8 Gy-Eq (range, 4.8-25.3), respectively. In the IV group, the maximal, mean, and minimal dose given to the gross tumor volume was 24.2 Gy-Eq (range, 21.5-29.9), 16.4 Gy-Eq (range, 14.5-20.2), and 7.8 Gy-Eq (range, 6.8-9.5), respectively. Within 1-3 months after BNCT, the responses were assessed. Of the 6 patients in the IV group, 2 had a partial response, 3 no change, and 1 had progressive disease. Of 4 patients in the IA group, 1 achieved a complete response and 3 a partial response.


CONCLUSIONS
Intra-arterial administration of boronophenylalanine is a promising drug delivery system for head-and-neck BNCT.
Suzuki
Minoru
M
Particle Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan. msuzuki@rri.kyot-u.ac.jp
Sakurai
Yoshinori
Y
Nagata
Kenji
K
Kinashi
Yuko
Y
Masunaga
Shinichiro
S
Ono
Koji
K
Maruhashi
Akira
A
Kato
Ituro
I
Fuwa
Nobukazu
N
Hiratsuka
Junichi
J
Imahori
Yoshio
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001896:Boron Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000532:radiotherapy*; D010649:Phenylalanine / Q000819:agonists* / Q000493:pharmacokinetics; D016896:Treatment Outcome
D001896:Boron Compounds; D010649:Phenylalanine