Influence of electrolytes/non-electrolytes on the cloud point phenomenon of the aqueous promethazine hydrochloride drug solution.
We have studied the clouding phenomena in promethazine hydrochloride (PMT) aqueous solutions in presence of electrolytes and non-electrolytes. PMT, a tranquillizer, shows phase separation. The cloud point (CP) decreases with increase in pH due to deprotonation of drug molecules. At constant pH, increasing salt addition causes an increase in CP, which is explained on the basis of their position in Hofmeister series and their hydrated radii. With quaternary salts CP increases due to adsorption/mixed micelle formation. Ureas decrease the CP and the behavior is explained on the basis of removal of water from the headgroup region.
Alam
Md Sayem
MS
Department of Chemistry, Aligarh Muslim University, Aligarh 202002, UP, India.
Naqvi
Andleeb Z
AZ
Kabir-ud-Din
D004573:Electrolytes / Q000737:chemistry*; D004655:Emulsions; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D011398:Promethazine / Q000737:chemistry*; D012995:Solubility; D012996:Solutions / Q000737:chemistry
D004573:Electrolytes; D004655:Emulsions; D008823:Micelles; D012996:Solutions; D011398:Promethazine