title: Significant loss of primordial follicles after prolonged gonadotropin stimulation in xenografts of cryopreserved human ovarian tissue in severe combined immunodeficient mice.
abstract: This study evaluated the effect of gonadotropin stimulation on the primordial follicle reserve of cryopreserved human ovarian tissue after transplantation in severe combined immunodeficient mice. We found that prolonged gonadotropin stimulation significantly reduces primordial follicles.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Erlangen, Erlangen, Germany.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Maltaris
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Beckmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Mueller
authors.forename: Inge
authors.initials: I
authors.lastname: Hoffmann
authors.forename: Joachim
authors.initials: J
authors.lastname: Kohl
authors.forename: Ralf
authors.initials: R
authors.lastname: Dittrich
mesh_terms: D000818:Animals; D015925:Cryopreservation / Q000379:methods*; D005260:Female; D006062:Gonadotropins / Q000008:administration & dosage*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D006080:Ovarian Follicle / Q000166:cytology* / Q000187:drug effects* / Q000637:transplantation; D010062:Ovulation Induction / Q000379:methods*; D014183:Transplantation, Heterologous / Q000379:methods
chemical_list: D006062:Gonadotropins