Novel poly(ADP-ribose) polymerase-1 inhibitors.
Synthesis and activity of a series of 4-thiazol-yl substituted analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been disclosed.
Dunn
Derek
D
Cephalon Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.
Husten
Jean
J
Ator
Mark A
MA
Chatterjee
Sankar
S
D000818:Animals; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D016716:PC12 Cells; D000071137:Poly (ADP-Ribose) Polymerase-1; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D051381:Rats; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
C518628:4-thiazol-yl pyrrolocarbazole; D002227:Carbazoles; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011994:Recombinant Proteins; D013844:Thiazoles; C499320:PARP1 protein, human; C499322:Parp1 protein, rat; D000071137:Poly (ADP-Ribose) Polymerase-1