title: [Proteins with GGDEF and EAL domains: their role in bacterial metabolism].
abstract: The availability of multiple bacterial genome sequences has led to the discovery of several conserved domains of proteins. Recently, GGDEF and EAL domains have been described as domains responsible for the synthesis and degradation of c-di-GMP, a second messenger in bacteria. c-di-GMP has been involved in cellulose production and identified as a global regulator of several processes such as biofilm formation, motility and virulence, presumibly through a modification of the cell surface properties.
authors.affiliation: Laboratorio de Microbiología y Genética Molecular, Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México.
authors.forename: Micaela Marcela
authors.initials: MM
authors.lastname: Méndez-Ortiz
authors.forename: Jorge
authors.initials: J
authors.lastname: Membrillo-Hernández
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D016935:Caulobacter crescentus / Q000378:metabolism; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000502:physiology*; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D012486:Salmonella typhimurium / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014734:Vibrio cholerae / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP