A mechanistic rationalization of unusual kinetic behavior in proline-mediated C-O and C-N bond-forming reactions.
Kinetic evidence supports the role of the reaction product in the catalytic cycle of proline-mediated alpha-aminoxylation and alpha-amination reactions, providing both design principles as well as a model for the evolution of efficiency in catalysis.
Mathew
Suju P
SP
Department of Chemistry, Imperial College, London, UK SW7 2AZ.
Klussmann
Martin
M
Iwamura
Hiroshi
H
Wells
David H
DH
Armstrong
Alan
A
Blackmond
Donna G
DG