Fructooligosaccharides consumption inhibits the loss of iron from the incisor enamel surface in gastrectomized rat.
We examined the effects of fructooligosaccharides (FOS) on the reduction in the incisor iron content in gastrectomized rat. Twenty-eight 5- wk-old male Sprague-Dawley rats were divided into two groups: sham operated (bSH) and gastrectomized (bGX). After 4 wk, each group was divided into two subgroups according to the presence or absence of 7.5% FOS in the synthetic diet (SH, SH+FOS, GX, and GX+FOS). At 10 wk after surgery, the maxilla was prepared to examine the iron content of the incisor enamel surface at four points. These points corresponded to the iron content at 6, 7, 8, and 10 wk, respectively. Blood was collected to determine serum iron levels at 4 and 10 wk. The serum iron level significantly decreased at 4 and 10 wk in the GX group. At 10 wk, the level in the GX+FOS group significantly increased but did not reach that in the SH group. The iron content of the enamel surface time-dependently increased and no significant differences were seen between SH and GX+FOS at 8 and 10 wk. These results suggest that FOS consumption impaired the loss of enamel content following gastrectomy, and this effect preceded the effect on the serum iron level.
Horikawa
Yasuhiro
Y
Department of Pediatric Dentistry, School of Dentistry, Showa University, Tokyo 142-8555, Japan.
Morohashi
Tomio
T
Sano
Tsuneyoshi
T
Sakai
Nobuhiro
N
Yamada
Shoji
S
Sasa
Ryuji
R
D000818:Animals; D003743:Dental Enamel / Q000378:metabolism*; D005743:Gastrectomy; D007180:Incisor / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D008297:Male; D009844:Oligosaccharides / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties; D015431:Weight Loss
D009844:Oligosaccharides; C116580:fructooligosaccharide; D007501:Iron