Association between the MTHFR A1298C polymorphism and increased risk of acute myeloid leukemia in Brazilian children.
Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate. The presence of polymorphisms that reduce the activity of MTHFR has been linked to the multifactor process of development of acute leukemia. A case control study was conducted on Brazilian children in different regions of the country with the aim of investigating the role of MTHFR C677T and A1298C polymorphisms as risk factors in the development of acute myeloid leukemia (AML). We used the polymerase chain reaction restriction fragment length polymorphism method to genotyping 182 AML and 315 healthy individuals. The genotype 677 CT was associated with decreased risk [odds ratio (OR), 0.37; confidence interval (CI) 95%, 0.14 - 0.92], whereas 1298 AC genotype was linked with an increased risk [OR, 2.90; CI 95%, 1.26 - 6.71] of developing AML in non-white children. Further epidemiological study is needed to unravel the complex multiple gene-environment interactions in the role of the AML leukemogenesis.
da Costa Ramos
Flavio Jose
FJ
Departamento de Genética, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Cartaxo Muniz
Maria Tereza
MT
Silva
Vanessa Cavalcante
VC
Araújo
Marcela
M
Leite
Ednalva Pereira
EP
Freitas
Elizabete Malaquias
EM
Zanrosso
Crisiane Wais
CW
Hatagima
Ana
A
de Mello
Maricilda Palandi
MP
Yunes
Jose Andrés
JA
Marques-Salles
Terezinha de Jesus
Tde J
Santos
Neide
N
Brandalise
Silvia R
SR
Pombo-De-Oliveira
Maria S
MS
D000293:Adolescent; D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics*; D012306:Risk
D042965:Methylenetetrahydrofolate Reductase (NADPH2)