title: [Study on comparative pharmacology of series of Muskone].
abstract: OBJECTIVE
  To study the therapeutic effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on experimental myocardial infarct and pain in rats.
  
  
  METHODS
  Coronary artery ligation was applied for the model of myocardial infarct. Therapeutic effects were evaluated by measuring parameters of histomorphometry, blood plasm of ET, 6- keto-PGF1alpha and TXB2. Intraperitoneal injection acetic was applied for the model of ache, the frequency and eclipse period of writhing were evaluated its effect of resisting pain.
  
  
  RESULTS
  The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all can decrease the area of myocardial infarction in rats, the level of TXB2, ET, and the frequency of writhing significantly. Also it can increase the level 6-keto-PGF1alpha, the ratio of 6-keto-PGF1alpha and TXB2. Single Radix Aristolociae or Radix Inulae only relieved pain.
  
  
  CONCLUSIONS
  The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all have significant therapeutic effect on both myocardial infarction and pain, while single Radix Aristolociae or Radix Inulae only can relieve pain.
authors.affiliation: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100700, China. makun123@sohu.com
authors.forename: Kun
authors.initials: K
authors.lastname: Ma
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Zhang
authors.forename: Yi-Kui
authors.initials: YK
authors.lastname: Li
authors.forename: Yong-Tao
authors.initials: YT
authors.lastname: Zhang
authors.forename: Li-Mao
authors.initials: LM
authors.lastname: Wu
authors.forename: Xiang-Ri
authors.initials: XR
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.forename: Lian-Da
authors.initials: LD
authors.lastname: Li
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D030022:Aristolochia / Q000737:chemistry; D003516:Cycloparaffins / Q000302:isolation & purification / Q000494:pharmacology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D016232:Endothelins / Q000097:blood; D005260:Female; D038143:Inula / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009203:Myocardial Infarction / Q000188:drug therapy*; D010146:Pain / Q000503:physiopathology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D003516:Cycloparaffins; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C031021:muscone