Synthesis and antiviral activity against tobacco mosaic virus and 3D-QSAR of alpha-substituted-1,2,3-thiadiazoleacetamides.
A series of alpha-substituted-1,2,3-thiadiazoleacetamides were prepared and tested in vitro against tobacco mosaic virus. The preliminary bioassays indicated that some of the new compounds are good as compared to the commercial pesticide Virus A at 500 mg/L, and the activity was influenced by the nature of the substituents. 3D-QSAR models were established based on the antiviral activity of the compounds. It has also been found that some of the new compounds also exhibit significant anti-HBV activity in human hepatoblastoma-derived liver Hep-G2 cells.
Zhao
Wei-Guang
WG
National Pesticide Engineering Research Center (Tianjin), State Key Laboratory of Elmento-Organic Chemistry, Nankai University, Tianjin 300071, PR China. zwg@nankai.edu.cn <zwg@nankai.edu.cn>
Wang
Jian-Guo
JG
Li
Zheng-Ming
ZM
Yang
Zhao
Z
D000081:Acetamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001393:Azoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000081:Acetamides; D000998:Antiviral Agents; D001393:Azoles