title: Assessing health-related quality of life in patients with Parkinson's disease in a prospective longitudinal study.
abstract: OBJECTIVE
  To prospectively assess the health-related quality of life (HrQoL) in Parkinson's disease (PD) during 12 months.
  
  
  METHODS
  HrQoL was assessed in 145 PD patients using the PD-specific PDQ-39, PDQL and the generic EQ-5D. In addition, clinical rating-scales were used.
  
  
  RESULTS
  All scales showed a pronounced effect of PD. In comparison to an age-matched population the EQ-5D was considerably affected. In comparison to baseline, however, there was no significant change in the generic scale but a significant change in the sum-score of disease-specific HrQoL-scales.
  
  
  CONCLUSIONS
  Only disease-specific scales were sensitive to change. Further studies are necessary to evaluate the time-dependent change in HrQoL.
authors.affiliation: Department of Neurology, Philipps-University Marburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Reuther
authors.forename: E A
authors.initials: EA
authors.lastname: Spottke
authors.forename: J
authors.initials: J
authors.lastname: Klotsche
authors.forename: O
authors.initials: O
authors.lastname: Riedel
authors.forename: H
authors.initials: H
authors.lastname: Peter
authors.forename: K
authors.initials: K
authors.lastname: Berger
authors.forename: O
authors.initials: O
authors.lastname: Athen
authors.forename: R
authors.initials: R
authors.lastname: Köhne-Volland
authors.forename: R C
authors.initials: RC
authors.lastname: Dodel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology*; D011594:Psychometrics; D011788:Quality of Life; D012720:Severity of Illness Index; D018434:Sickness Impact Profile