title: Renal cell carcinoma associated with prominent angioleiomyoma-like proliferation: Report of 5 cases and review of the literature.
abstract: Five cases of renal cell carcinoma of clear cell type are presented, Fuhrmann's grade 2, associated with a peculiar stromal proliferation having angioleiomyoma-like features. This proliferation was particularly prominent at the interphase between the tumor edge and the surrounding normal tissues, in which it acquired the configuration of a tumor capsule. Four similar cases were taken from the literature. We postulate that this angioleiomyoma-like change is a tumor epiphenomenon and that it represents yet another manifestation of the well-documented capacity of renal cell carcinoma to induce vascular proliferation, probably through the secretion of angiogenic and other growth factors by the tumor cells.
authors.affiliation: Centro Consulenze Anatomia Patologica Oncologica, Centro Diagnostico Italiano, Milan, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Kuhn
authors.forename: Jazmìn
authors.initials: J
authors.lastname: De Anda
authors.forename: Samanta
authors.initials: S
authors.lastname: Manoni
authors.forename: George
authors.initials: G
authors.lastname: Netto
authors.forename: Juan
authors.initials: J
authors.lastname: Rosai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018229:Angiomyoma / Q000378:metabolism / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged