Cerebrocerebellar circuits for the perceptual cancellation of eye-movement-induced retinal image motion.
Despite smooth pursuit eye movements, we are unaware of resultant retinal image motion. This example of perceptual invariance is achieved by comparing retinal image slip with an internal reference signal predicting the sensory consequences of the eye movement. This prediction can be manipulated experimentally, allowing one to vary the amount of self-induced image motion for which the reference signal compensates and, accordingly, the resulting percept of motion. Here we were able to map regions in CRUS I within the lateral cerebellar hemispheres that exhibited a significant correlation between functional magnetic resonance imaging signal amplitudes and the amount of motion predicted by the reference signal. The fact that these cerebellar regions were found to be functionally coupled with the left parieto-insular cortex and the supplementary eye fields points to these cortical areas as the sites of interaction between predicted and experienced sensory events, ultimately giving rise to the perception of a stable world despite self-induced retinal motion.
Lindner
Axel
A
Hertie-Institut für Clinical Brain Research, Department of Cognitive Neurology, Tübingen, Germany. alindner@caltech.edu
Haarmeier
Thomas
T
Erb
Michael
M
Grodd
Wolfgang
W
Thier
Peter
P
D001931:Brain Mapping; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008959:Models, Neurological; D009039:Motion Perception / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011601:Psychophysics; D012016:Reference Values; D012160:Retina / Q000502:physiology*; D014795:Visual Pathways / Q000098:blood supply / Q000502:physiology*