Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT.
Deciphering gene regulatory networks requires the systematic identification of functional cis-acting regulatory elements. We present a suite of web-based bioinformatics tools, called GeneACT http://promoter.colorado.edu, that can rapidly detect evolutionarily conserved transcription factor binding sites or microRNA target sites that are either unique or over-represented in differentially expressed genes from DNA microarray data. GeneACT provides graphic visualization and extraction of common regulatory sequence elements in the promoters and 3'-untranslated regions that are conserved across multiple mammalian species.
Cheung
Tom Hiu
TH
Department of Chemistry and Biochemistry, University of Colorado, 215 UCB, Boulder, Colorado 80309, USA.
Kwan
Yin Lam
YL
Hamady
Micah
M
Liu
Xuedong
X
D000818:Animals; D016678:Genome; D015894:Genome, Human; D006801:Humans; D051379:Mice; D051381:Rats; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic