Interleukin-10 promoter polymorphisms in male and female fertility and fecundity.
Interleukin-10 (IL10) is assumed beneficial for a successful pregnancy; it may increase fertility and fecundity. Allele frequencies of IL10 polymorphisms at position -2849, -1082 and -592 were analyzed in association with a past history of fertility and fecundity in men and women of at least 85 years old. Fertility was decreased in association with the -2849 A allele in females; 27% of the AA genotype carriers produced no offspring in marriage compared to 14% of the G allele carriers (odds ratio (OR): 2.2, 95% confidence interval (CI): 1.2-4.2, P=0.01). Effective fecundability was decreased in association with the -2849 A allele in females; 7% of female -2849 AA genotype carriers had a child within 371 days of marriage (therefore, conceived within 3 months of marriage) compared to 28% of female G allele carriers (OR: 0.2, 95% CI: 0.04-0.7, P=0.01). This suggests an association between the -2849 AA genotype and a decreased fertility and fecundity in females.
van Dunné
F M
FM
Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands. frederique@vandunne.tk
de Craen
A J M
AJ
Helmerhorst
F M
FM
Huizinga
T W J
TW
Westendorp
R G J
RG
D000369:Aged, 80 and over; D005260:Female; D005298:Fertility / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D009426:Netherlands; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*
D016753:Interleukin-10