Y-chromosomal microsatellite mutation rates in a population sample from northwestern Germany.
To estimate Y-chromosomal short tandem repeat (Y-STR) mutation rates, 15 loci (i.e., DYS19, DYS389 I/II, DYS390, and DYS393; DYS437, DYS438, DYS439, and DYS385; DYS391, DYS392, YCA II, and DXYS156) were analyzed in a sample of 1,029 father/son pairs from Westphalia, northwestern Germany. Among 15,435 meiotic allele transfers, 32 mutations were observed; thus, the mutation rate across all 15 Y-STR loci was 2.1 x 10(-3) per locus (95% C.I.: 1.5-3.0 x 10(-3)). With the exception of a three-repeat mutation at DYS385, all remaining mutations were single repeat mutations. Repeat losses were more frequent than gains (20:12), and the mutation rate appeared to increase with age. The Y haplogroups that were detected in the individuals showing a mutation reflect the haplogroup distribution in the Westphalian population. Additionally, the correlation of surnames and haplotypes was tested: Only 49 surnames occurred more than once, and only two men with the same rare surname shared the same haplotype. All other men with identical surnames carried different haplotypes.
Hohoff
Carsten
C
Institut für Rechtsmedizin, Universitätsklinikum Münster, Röntgenstrasse 23, 48149 Münster, Germany.
Dewa
Koji
K
Sibbing
Ulla
U
Hoppe
Karolin
K
Forster
Peter
P
Brinkmann
Bernd
B
D000483:Alleles; D041322:Chromosomes, Human, Y; D005828:Genetics, Population; D005858:Germany; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009154:Mutation