title: Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity.
abstract: We sought to determine whether pretreatment low pol replication capacity (polRC) is associated with CD4 T-cell count gains during antiretroviral therapy (ART). Patients were recruited at north American and Australian sites. Viral polRC was measured before starting ART in all subjects. We examined 243 individuals for a median 260 days after initiating ART. Low baseline polRC was associated with greater CD4 T-cell gains independent of virological responses.
authors.affiliation: Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Barbour
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Hecht
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Little
authors.forename: Martin
authors.initials: M
authors.lastname: Markowitz
authors.forename: Eric S
authors.initials: ES
authors.lastname: Daar
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Kelleher
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Routy
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Campbell
authors.forename: Eric S
authors.initials: ES
authors.lastname: Rosenberg
authors.forename: Mark R
authors.initials: MR
authors.lastname: Segal
authors.forename: Jodi
authors.initials: J
authors.lastname: Weidler
authors.forename: Robert M
authors.initials: RM
authors.lastname: Grant
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005500:Follow-Up Studies; D015751:Genes, pol / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D011379:Prognosis; D012367:RNA, Viral / Q000097:blood; D014779:Virus Replication / Q000235:genetics
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral