Monitoring the health to disease continuum with global metabolic profiling and systems biology.
Global metabolic profiling, which includes both metabolomics and metabonomics studies, is the latest 'omics' research platform that is being applied to understand the health and disease continuum. Metabolic profiling analyses have been demonstrated for the investigation of inborn errors of metabolism, organ transplant rejection, drug toxicity, disease diagnosis and prognosis, drug efficacy and nutritional status. Combining information generated from a metabolic profiling platform with that obtained based on genetics, transcriptomics and proteomics research paradigms will pave the way for a better understanding of the mechanisms of disease and toxicity. Metabolomics and nutrition will lay the groundwork for the application of personalized medicine in the 21st century.
Schnackenberg
Laura K
LK
Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA. laura.schnackenberg@fda.hhs.gov
Beger
Richard D
RD
D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D064420:Drug-Related Side Effects and Adverse Reactions; D020869:Gene Expression Profiling; D006801:Humans; D008660:Metabolism / Q000235:genetics*; D008661:Metabolism, Inborn Errors / Q000175:diagnosis / Q000235:genetics; D009747:Nutritional Physiological Phenomena; D049490:Systems Biology / Q000639:trends*