title: Conditional and replicative senescence in Escherichia coli.
abstract: Analysis of the molecular mechanisms underlying the cellular degeneration of bacteria in stationary phase (known as conditional senescence) reveals interesting similarities with the aging process of higher organisms. These similarities include the role of self-inflicted oxidative damage and the importance of protein quality control systems in retarding senescence. In addition, recent data suggests that Escherichia coli cells display signs of replicative senescence, or loss of fitness, during exponential growth and that this phenomenon targets the 'older' cells. Thus, bacterial physiology might entail both conditional and mandatory aging processes.
authors.affiliation: Department of Cell and Molecular Biology Microbiology, Göteborg University, Box 462, 405 30 Göteborg, Sweden.
authors.forename: Asa
authors.initials: A
authors.lastname: Fredriksson
authors.forename: Thomas
authors.initials: T
authors.lastname: Nyström
mesh_terms: D000222:Adaptation, Physiological; D002453:Cell Cycle / Q000502:physiology*; D016922:Cellular Senescence / Q000187:drug effects / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species