[Cutaneous necrosis due to interferon alpha in a patient with melanoma].
We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN.
Aguilar García
Guadalupe
G
Servicio de Dermatología, Hospital Clínico Universitario San Cecilio, Granada, España. guadaguilar@hohtmail.com
Serrano Falcón
Cristina
C
Serrano Falcón
Maria del Mar
Mdel M
Carmona
Maria Dolores
MD
Linares Solano
Juan
J
Serrano Ortega
Salvio
S
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001132:Arm; D017024:Chemotherapy, Adjuvant; D003646:Debridement; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced* / Q000473:pathology; D009824:Ointments; D011994:Recombinant Proteins; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012883:Skin Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000601:surgery; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009824:Ointments; D011994:Recombinant Proteins