Switching stereoselectivity in rhodium-catalysed 1,4-additions: The asymmetric synthesis of 2-substituted pyrrolizidinones.
The appropriate choice of organometallic nucleophile enables the straightforward preparation of different stereoisomers of 2-substituted pyrrolizidinones utilising the rhodium-catalysed 1,4-addition reaction.
Hargrave
Jonathan D
JD
Department of Chemistry, University of Bath, Claverton Down, Bath, UK BA2 7AY.
Bish
Gerwyn
G
Frost
Christopher G
CG