title: [Expression of estrogen receptor-related receptor alpha and estrogen receptor alpha in endometrial carcinoma and the primary investigation of their clinical significance].
abstract: OBJECTIVE
  To explore the roles of estrogen receptor-related receptor (ERR) alpha and estrogen receptor alpha in endometrial carcinoma and their clinical values.
  
  
  METHODS
  Thirty-five cases of endometrial carcinoma were examined by immunohistochemistry. Clinicopathologic features including FIGO stage, histological grade, myometrial invasion and nodal metastasis were reviewed.
  
  
  RESULTS
  The expression rate of ERalpha in patients with FIGO stage I endometrial carcinoma was more than that in stage II-IV(P = 0.005). The expression rate of ERRalpha in endometrial carcinoma patients at FIGO stage I was lower than that at stages II-IV(P = 0.007). The percentage of patients at FIGO stageI or with G1-2 or myometrial invasion < 1/2 in ERalpha (+) and ERRalpha (-) groups was higher than that in ERalpha (-) and ERRalpha (+) groups(P = 0.000, P = 0.031 and P = 0.022).
  
  
  CONCLUSIONS
  ERalpha may be a biomarker of good prognosis while ERRalpha may serve as a biomarker of poor prognosis in endometrial carcinoma. The combinative measure of ERalpha and ERRalpha may improve the prognostic value.
authors.affiliation: Department of Gynecology, Peking University Peopleos Hospital, Beijing 100044, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.forename: Li-hui
authors.initials: LH
authors.lastname: Wei
authors.forename: Peng-ming
authors.initials: PM
authors.lastname: Sun
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology*; D047628:Estrogen Receptor alpha / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D014408:Biomarkers, Tumor; D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor