Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report.
Systemic lupus erythematosus (SLE) and autoimmune hepatitis are distinct clinical disorders, which rarely occur, in the same patient. We describe a 59-year-old woman with coexistence of both conditions. Photosensitivity, arthritis, positive ANA, and extreme elevation of anti-dsDNA concluded the diagnosis of SLE. Hyperbilirubinemia, high serum value of liver function, and elevation of alpha-fetoprotein were also prominent. By a review of pertinent literature, clinical investigation, calculation of autoimmune hepatitis score, and pathology of liver biopsy specimen, we were in favor of autoimmune hepatitis. Awareness of this rare presentation may be beneficial to clinicians in identifying and treating patients with both SLE and autoimmune hepatitis.
Liu
Feng-Cheng
FC
Division of Rheumatology/Immunology/Allergy, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan, ROC. lfc10399@yahoo.com.tw
Chang
Deh-Ming
DM
Lai
Jenn-Huang
JH
Lin
Chih-Kung
CK
Chen
Hsiang-Cheng
HC
Hou
Tsung-Yun
TY
Kuo
San-Yuan
SY
D003937:Diagnosis, Differential; D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000276:immunology / Q000378:metabolism*
D000509:alpha-Fetoproteins