title: Antioxidative phenolics from the fresh leaves of Ternstroemia japonica.
abstract: Six new phenylethanoid glucosides, ternstrosides A-F (1-6), a new kaempferol derivative (7), and eight known compounds were isolated from the fresh leaves of Ternstroemia japonica. The structures were elucidated by 1D and 2D NMR spectroscopic analyses. Compounds 1-7 showed potent antioxidative activity in three different tests, with IC50 values in the range 3.26-6.50 microM in the hydroxyl radical (*OH) inhibitory activity test, 33.29-82.21 microM in the total ROS (reactive oxygen species) inhibitory activity test, and 1.14-13.53 microM in the peroxynitrite (ONOO-) scavenging activity test.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Jo
authors.forename: Minkyung
authors.initials: M
authors.lastname: Kim
authors.forename: Myung Hee
authors.initials: MH
authors.lastname: Shin
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029791:Ericaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007668:Kidney / Q000166:cytology; D007723:Korea; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D030421:Peroxynitrous Acid / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D005960:Glucosides; D010636:Phenols; D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid; D017665:Hydroxyl Radical