[The PQQ-dehydrogenases. A novel example of bacterial quinoproteins].
The word "quinoprotein" describes four groups of different enzymes which have cofactors containing o-quinones. Pyrrolo-quinoline quinone (PQQ) is not covalently attached. PQQ is the cofactor of several quinoprotein bacterial dehydrogenases including glucose dehydrogenase (G-DH), alcohol dehydrogenase (A-DH) and aldehyde dehydrogenase (AL-DH). These dehydrogenases are located in the periplasm of Gram-negative bacteria. This report summarises the structural properties of quinoprotein dehydrogenases, such as the biological functions and biotechnological aspects more important.
Flores-Encarnación
Marcos
M
Departamento de Ciencias de la Salud, Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla. mflores31@hotmail.com
Sánchez-Cuevas
Mariano
M
Ortiz-Gutiérrez
Felipe
F
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D001709:Biotechnology; D002262:Carboxy-Lyases / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives / Q000378:metabolism; D004783:Environmental Microbiology; D005948:Glucose Dehydrogenases / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000201:enzymology*; D045563:Indolequinones / Q000378:metabolism; D007218:Industrial Microbiology; D020601:Methylobacterium extorquens / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D045542:PQQ Cofactor / Q000502:physiology*; D011487:Protein Conformation; D014364:Tryptophan / Q000031:analogs & derivatives / Q000378:metabolism
D001426:Bacterial Proteins; D045563:Indolequinones; C070569:tryptophan tryptophylquinone; D004295:Dihydroxyphenylalanine; C067626:6-hydroxydopa quinone; D045542:PQQ Cofactor; D014364:Tryptophan; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; D005948:Glucose Dehydrogenases; C019641:alcohol dehydrogenase (acceptor); C033955:glucose dehydrogenase (pyrroloquinoline-quinone); D000444:Aldehyde Dehydrogenase; D002262:Carboxy-Lyases