title: Generalized lichen ruber planus--induced by radiotherapy of the breast?
abstract: BACKGROUND
  Lichen ruber planus is an inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. The etiology is unknown.
  
  
  METHODS
  A 56-year-old female was treated with standard local radiotherapy after breast-conserving surgery due to high-grade ductal carcinoma in situ (DCIS) of the breast.
  
  
  RESULTS
  During radiotherapy, the patient began to complain about increasing disseminated itching papules of the breast. The efflorescences appeared as flat-topped, solid, purplish papules spreading to the limbs and trunk. A thorough clinical examination revealed additionally suspicious cob-web like and white-coated mucosal lesions of the oral cavity consistent with the clinical diagnosis of a generalized lichen ruber planus with an oral manifestation.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of a generalized manifestation of lichen ruber planus presumably induced by radiation therapy.
authors.affiliation: Department of Gynecology and Obstetrics, University of Heidelberg Medical School, Heidelberg, Germany. Michael.Eichbaum@med.uni-heidelberg.de
authors.forename: Michael
authors.initials: M
authors.lastname: Eichbaum
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Harms
authors.forename: Sven
authors.initials: S
authors.lastname: Bolz
authors.forename: Andreas
authors.initials: A
authors.lastname: Schneeweiss
authors.forename: Christof
authors.initials: C
authors.lastname: Sohn
mesh_terms: D001943:Breast Neoplasms / Q000150:complications / Q000628:therapy*; D044584:Carcinoma, Ductal / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000175:diagnosis* / Q000209:etiology*; D008875:Middle Aged; D011855:Radiodermatitis / Q000175:diagnosis* / Q000209:etiology*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects*