title: Update in pathophysiology and histopathology of focal segmental glomerulosclerosis.
abstract: Focal segmental glomerulosclerosis (FSGS) is the leading cause of nephrotic syndrome in an adult worldwide. The prevalence of FSGS is estimated as being 20-30% in adults over the age of 15 years and slightly higher (30-35%) in the elderly (age > 60 years). The diagnosis solely relies on pathologic findings, which sclerosis involves some, but not all glomeruli (focal), and sclerosis affects a portion, but not the entire, glomerular tuft (segmental). The pathogenesis remains inconclusive but podocyte injury has been postulated. Even though steroid is the mainstay treatment, only 20-40% of patients are complete respond.
authors.affiliation: Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand. golfnephro@hotmail.com
authors.forename: Talerngsak
authors.initials: T
authors.lastname: Kanjanabuch
authors.forename: Songkiat
authors.initials: S
authors.lastname: Lewsuwan
authors.forename: Chagriya
authors.initials: C
authors.lastname: Kitiyakara
authors.forename: Boonyarit
authors.initials: B
authors.lastname: Cheunsuchon
authors.forename: Somchai
authors.initials: S
authors.lastname: Eiam-Ong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology*; D050199:Podocytes / Q000473:pathology