Plasma resistin, insulin concentration in non-diabetic and diabetic, overweight/obese Thai.
This study investigated levels of fasting plasma glucose (FBS), homeostasis model of the assessment of the insulin resistance (HOMA), lipid profile, insulin, and resistin hormones in 202 individuals, divided into four groups. Two groups had type II diabetes mellitus (DM): one group had been overnourished (DM/OB) (body mass index: BMI equal or above 25) and the other had not (DM/nOB). Two additional groups not suffering from diabetes were either overnourished (nDM/OB) or of normal nutritional status (nDM/nOB). Only the DM/OB group had insulin levels elevated above the other three groups. Resistin levels had been lowest in the nDM/nOB group. When participants of the two nOB groups were pooled into one group and the subjects of the two OB groups were combined into another group, the median plasma resistin levels of the OB groups were significantly higher compared with the nOB groups. Likewise the DM groups had higher resistin levels than the nDM groups. A significant correlation of plasma resistin with BMI, waist circumference, waist-to-hip ratio, FBS, and HOMA score had been observed. The result suggests that plasma resistin has a role in linking central obesity and obesity-related insulin resistance to type II diabetes mellitus.
Chanchay
Siriporn
S
Department of Tropical Nutrition and food Science, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand.
Tungtrongchitr
Rungsunn
R
Harnroongroj
Talabporn
T
Phonrat
Benjaluck
B
Rungseesakorn
Orapin
O
Paksanont
Suporn
S
Pooudong
Somchai
S
Saowakontha
Sastri
S
Varongchayakul
Chusak
C
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D050177:Overweight; D011863:Radioimmunoassay; D052243:Resistin / Q000097:blood*; D012885:Skinfold Thickness; D013785:Thailand / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D052243:Resistin; D014280:Triglycerides