title: Clostridium perfringens antigens recognized by broiler chickens immune to necrotic enteritis.
abstract: Little is known about immunity to necrotic enteritis (NE) in chickens. A recent study of broiler chickens showed that protection against NE was associated with infection-immunization with virulent but not with avirulent Clostridium perfringens. In the current study, six secreted antigenic proteins unique to virulent C. perfringens that reacted to serum antibodies from immune birds were identified by mass spectrophotometry; three of these proteins are part of the VirR-VirS regulon.
authors.affiliation: Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
authors.forename: R R
authors.initials: RR
authors.lastname: Kulkarni
authors.forename: V R
authors.initials: VR
authors.lastname: Parreira
authors.forename: S
authors.initials: S
authors.lastname: Sharif
authors.forename: J F
authors.initials: JF
authors.lastname: Prescott
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000378:metabolism; D001426:Bacterial Proteins / Q000276:immunology / Q000378:metabolism; D002645:Chickens / Q000276:immunology*; D003015:Clostridium Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D003016:Clostridium perfringens / Q000276:immunology* / Q000472:pathogenicity; D004751:Enteritis / Q000276:immunology / Q000662:veterinary*; D007106:Immune Sera / Q000276:immunology*; D009336:Necrosis / Q000276:immunology / Q000662:veterinary; D011201:Poultry Diseases / Q000276:immunology* / Q000382:microbiology; D014774:Virulence
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007106:Immune Sera