title: Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12.
abstract: BACKGROUND
  We are interested in identifying susceptibility genes that predispose subjects to attempted suicide.
  
  
  METHODS
  We conducted a secondary analysis of genome-wide linkage data from 162 bipolar pedigrees that incorporated attempted suicide as a clinical covariate.
  
  
  RESULTS
  The strongest covariate-based linkage signal was seen on 2p12 at marker D2S1777. The logarithm of odds (LOD) score at marker D2S1777 rose from 1.56 to 3.82 after inclusion of the suicide covariate, resulting in significant chromosome-wide empirically derived p-values for the overall linkage finding (p = .01) and for the change in LOD score after the inclusion of the covariate (p = .02).
  
  
  CONCLUSIONS
  The finding on chromosome 2 replicates results from two previous studies of attempted suicide in pedigrees with alcohol dependence and in pedigrees with recurrent early-onset depression. Combined, these three studies provide compelling evidence for a locus influencing attempted suicide on 2p12.
authors.affiliation: Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. willour@jhmi.edu
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Willour
authors.forename: Peter P
authors.initials: PP
authors.lastname: Zandi
authors.forename: Judith A
authors.initials: JA
authors.lastname: Badner
authors.forename: Jo
authors.initials: J
authors.lastname: Steele
authors.forename: Kuangyi
authors.initials: K
authors.lastname: Miao
authors.forename: Victor
authors.initials: V
authors.lastname: Lopez
authors.forename: Dean F
authors.initials: DF
authors.lastname: MacKinnon
authors.forename: Francis M
authors.initials: FM
authors.lastname: Mondimore
authors.forename: Barbara
authors.initials: B
authors.lastname: Schweizer
authors.forename: Melvin G
authors.initials: MG
authors.lastname: McInnis
authors.forename: Erin B
authors.initials: EB
authors.lastname: Miller
authors.forename: J Raymond
authors.initials: JR
authors.lastname: Depaulo
authors.forename: Elliot S
authors.initials: ES
authors.lastname: Gershon
authors.forename: Francis J
authors.initials: FJ
authors.lastname: McMahon
authors.forename: James B
authors.initials: JB
authors.lastname: Potash
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D010375:Pedigree; D018709:Statistics, Nonparametric; D013406:Suicide, Attempted