Redox imbalance in patients with coronary artery disease showing progression of atherosclerotic lesions.
OBJECTIVE
To clarify the relationship between changes in redox balance and the development of new coronary lesions in patients with coronary artery disease (CAD).


METHODS
We studied 82 CAD patients (70 males and 12 females, mean age 61.8 +/- 9.2 years) who underwent repeated coronary angiography within 1 year after percutaneous coronary intervention. Levels of serum lipid peroxide, erythrocyte glutathione peroxidase activity, and the redox state of erythrocyte (ratio of reduced to oxidized glutathione, the GSH/GSSG ratio) were measured at the time of follow-up coronary angiography. According to the development of significant stenotic lesions, we divided the patients into two groups: 57 patients without the development of new stenotic lesions (group A) and 25 patients showing new significant stenotic lesions within 1 year (group B).


RESULTS
The serum lipid peroxide level in group B was significantly higher than those of group A (2.61 +/- 0.32 vs 1.74 +/- 0.16 nmol/ml, p < 0.01). Erythrocyte glutathione peroxidase activity did not differ significantly between two groups. The erythrocyte GSH/GSSG ratio in group B was significantly lower than that of group A (83 +/- 9.6 vs 126 +/- 7.3, p < 0.01). The sensitivity and specificity of GSH/GSSG ratio to detect CAD patients with the development of significant coronary stenosis were 80.0% and 61.4%, respectively.


CONCLUSIONS
CAD patients who showed development of new coronary lesions within 1 year have increased oxidative stress and imbalanced erythrocyte redox state. The GSH/GSSG ratio, an indicator for redox balance, could be a useful marker to identify high-risk CAD patients.
Tsuru
Rie
R
Department of Cardiology, School of Medicine, Jichi Medical University, Tochigi.
Hojo
Yukihiro
Y
Gama
Miyuki
M
Mizuno
Osamu
O
Katsuki
Takaaki
T
Shimada
Kazuyuki
K
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D023903:Coronary Restenosis / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005500:Follow-Up Studies; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction
D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D005978:Glutathione