[Liuweidihuang pills reduces visceral fat deposition in Otsuka Long-Evans Tokushima Fatty rats].
OBJECTIVE
To investigate the effects of Liuweidihuang pills (LP) on visceral fat deposition in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.


METHODS
Forty male OLETF rats were randomly divided into LP group and control group (n=20 per group), and 10 male Long-evans Tokushima Otsuka (LETO) rats were used as normal controls. The rats in LP group were given LP(2.4 mg/kg) daily by intragastric administration since the age of 8 weeks, and those in the other two groups were given water of the same volume by intragastric administration. Blood glucose of all the rats was determined by oral glucose tolerance test (OGTT) and visceral fat deposition examined after the rats were sacrificed.


RESULTS
OLETF rats had obviously greater amount of visceral fat than LETO rats (P<0.05) and administration of LP ameliorated the increment of visceral fat deposition in this type 2 diabetic model, producing significant effect at the age of 40 weeks (P<0.01).


CONCLUSIONS
LP may effectively decrease visceral fat deposition in OLETF rats.
Xue
Yao-ming
YM
Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. brightxue@163.com
Luo
Ren
R
Zhu
Bo
B
Zhang
Yan
Y
Pan
Yong-hua
YH
Li
Chen-zhong
CZ
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D050152:Intra-Abdominal Fat / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009765:Obesity / Q000473:pathology / Q000517:prevention & control; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D020334:Rats, Inbred OLETF
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; C476907:liu-wei-di-huang wan