title: A case of acute myocardial infarction during 5-fluorouracil infusion.
abstract: Cardiac toxicity is an uncommon side-effect of 5-fluorouracil (5-FU) treatment, consisting mainly of chest pain episodes with or without electrocardiographic changes and dysrhythmias. Here, we describe the case of a 56-year-old male patient with a diagnosis of advanced colorectal cancer who developed an acute myocardial infarction during 5-FU infusion. The patient was not affected by prior heart disease and did not show any classic risk factors for coronary heart disease. Coronary angiography examination revealed no evidence of coronary stenosis, supporting the hypothesis of a coronary artery spasm related to 5-FU infusion. Given the great number of cancer patients receiving 5-FU containing chemotherapeutic regimens, this rare but severe cardiac side-effect may be observed in both cardiologic and oncologic clinical practice. We suggest a tight clinical monitoring of all patients receiving 5-FU infusions, even in those without a prior history of heart disease.
authors.affiliation: U.O. Malattie Cardiovascolari I Universitaria, Dipartimento Cardiotoracico, Italy. marialauracanale@katamail.com
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Canale
authors.forename: Andrea
authors.initials: A
authors.lastname: Camerini
authors.forename: Stefano
authors.initials: S
authors.lastname: Stroppa
authors.forename: Romana Prosperi
authors.initials: RP
authors.lastname: Porta
authors.forename: Paolo
authors.initials: P
authors.lastname: Caravelli
authors.forename: Mario
authors.initials: M
authors.lastname: Mariani
authors.forename: Alberto
authors.initials: A
authors.lastname: Balbarini
authors.forename: Sergio
authors.initials: S
authors.lastname: Ricci
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D017023:Coronary Angiography; D052279:Creatine Kinase, MB Form / Q000097:blood; D004562:Electrocardiography; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors; D019210:Troponin I / Q000097:blood
chemical_list: D000964:Antimetabolites, Antineoplastic; D019210:Troponin I; D052279:Creatine Kinase, MB Form; D005472:Fluorouracil