title: Peroxisomal membrane permeability and solute transfer.
abstract: The review is dedicated to recent progress in the study of peroxisomal membrane permeability to solutes which has been a matter of debate for more than 40 years. Apparently, the mammalian peroxisomal membrane is freely permeable to small solute molecules owing to the presence of pore-forming channels. However, the membrane forms a permeability barrier for 'bulky' solutes including cofactors (NAD/H, NADP/H, CoA, and acetyl/acyl-CoA esters) and ATP. Therefore, peroxisomes need specific protein transporters to transfer these compounds across the membrane. Recent electrophysiological studies have revealed channel-forming activities in the mammalian peroxisomal membrane. The possible involvement of the channels in the transfer of small metabolites and in the formation of peroxisomal shuttle systems is described.
authors.affiliation: Department of Biochemistry and Biocenter Oulu, University of Oulu, P.O. Box 3000, FIN-90014 Oulu, Finland. vasily.antonenkov@oulu.fi
authors.forename: Vasily D
authors.initials: VD
authors.lastname: Antonenkov
authors.forename: J Kalervo
authors.initials: JK
authors.lastname: Hiltunen
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D003065:Coenzyme A / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008954:Models, Biological; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010539:Permeability; D020675:Peroxisomes / Q000378:metabolism*; D011755:Pyrophosphatases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D000096964:Nudix Hydrolases
chemical_list: D000255:Adenosine Triphosphate; D003065:Coenzyme A; D026901:Membrane Transport Proteins; D009243:NAD; D009249:NADP; D011755:Pyrophosphatases; D017382:Reactive Oxygen Species; D000096964:Nudix Hydrolases