Antidiabetic activity of hydro-ethanolic extract of Cyperus rotundus in alloxan induced diabetes in rats.
In light of the traditional claim of Cyperus rotundus in the treatment of diabetes, investigations were carried out to evaluate its effect on alloxan induced hyperglycemia in rats. Oral daily administration of 500 mg/kg of the extract (once a day for seven consecutive days) significantly lowered the blood glucose levels. This antihyperglycemic activity can be attributed to its antioxidant activity as it showed the strong DPPH radical scavenging action in vitro.
Raut
Nishikant A
NA
Department of Pharmaceutical Sciences, R. T. M. Nagpur University Campus, Amravati Road, Nagpur-440 033, India. rnishi@sify.com
Gaikwad
Naresh J
NJ
D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D001786:Blood Glucose / Q000187:drug effects; D029786:Cyperus; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome
D000975:Antioxidants; D001713:Biphenyl Compounds; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010851:Picrates; D010936:Plant Extracts; D000496:Alloxan; C004931:1,1-diphenyl-2-picrylhydrazyl