A computational model for motor pattern switching between taste-induced ingestion and rejection oromotor behaviors.
The mechanism of switching activity patterns in a central pattern generator is fundamental to the generation of diverse motor behaviors. Based on what is known about a brainstem substrate mediating the oral components of ingestion and rejection, we use computational techniques to construct a hypothetical multifunctional network that switches between the motor outputs of ingestion (licking) and rejection (gaping). The network was constructed using single-compartment conductance-based models for individual neurons based on Hodgkin-Huxley formalism. Using a fast-slow reduction and geometric analysis we describe a mechanism for pattern switching between licks and gapes. The model supports the hypothesis that a single configuration of network connections can produce both activity patterns. It further predicts that prolonged inhibition of some network neurons could lead to a switch in network activity from licks to gapes.
Venugopal
Sharmila
S
Neuroscience Graduate Studies Program, The Ohio State University, 305 W 12th Avenue, Columbus, OH 43210, USA. venugopal.7@osu.edu
Travers
Joseph B
JB
Terman
David H
DH
D000818:Animals; D003198:Computer Simulation; D003679:Deglutition / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005247:Feeding Behavior; D008564:Membrane Potentials / Q000502:physiology; D008954:Models, Biological; D009043:Motor Activity / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology; D013284:Stomatognathic System / Q000502:physiology*; D013649:Taste / Q000502:physiology*