title: Citicoline is not protective in experimental models of Huntington's disease.
abstract: We have evaluated the neuroprotective effects of citicoline in relevant phenotypic models of Huntington's disease induced by either the mitochondrial inhibitor 3-nitropropionic acid or the N-methyl-D-aspartate agonist quinolinic acid, which, respectively, reproduce the metabolic defect or the excitotoxicity seen in the disease. We found that citicoline failed to reverse behavioural and histological alterations induced by both neurotoxins. In addition, citicoline did not reduce PC12 cell death induced by the expression of an N-terminal fragment of mutated Huntingtin. Altogether, our results suggest that citicoline is not a potential therapeutic agent for the treatment of Huntington's disease.
authors.affiliation: IRIBHM, University of Brussels, ULB-Erasme, Brussels, Belgium.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mievis
authors.forename: Marc
authors.initials: M
authors.lastname: Levivier
authors.forename: Gilbert
authors.initials: G
authors.lastname: Vassart
authors.forename: Jacques
authors.initials: J
authors.lastname: Brotchi
authors.forename: Catherine
authors.initials: C
authors.lastname: Ledent
authors.forename: David
authors.initials: D
authors.lastname: Blum
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006816:Huntington Disease / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D018696:Neuroprotective Agents / Q000008:administration & dosage; D018697:Nootropic Agents; D051381:Rats; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline