[Effect of L-arginine on diabetic rats].
OBJECTIVE
To observe the effect of L-arginine on diabetic rats.


METHODS
Forty adult male Lewis rats were randomized equally into diabetic and normal control groups, and the former rats were treated intraperitoneally with streptozotocin to induce diabetes mellitus. Seven days later, half of the diabetic and normal rats were injected intraperitoneally with L-arginine at the daily dose of 1 g/kg, while the remainder were given saline instead. All the rats were euthanized on 10 days after L-arginine or saline treatment, and their body weight, plasma protein, arginine and sugar, food and water intake were analyzed.


RESULTS
Diabetic rats had obviously decreased body weight, plasma protein and arginine but increased blood sugar and food and water intakes in comparison with the control rats. L-arginine significantly increased plasma protein and arginine, decreased food and water intakes, but failed to prevent weight loss and blood sugar increment in diabetic rats as compared to their saline-treated counterparts. L-arginine supplementation did not result in any changes other than arginine elevation in the control rats.


CONCLUSIONS
L-arginine supplementation can partially improve polydipsia and polyphagia and increase plasma protein in diabetic rats.
Lü
Wei-ming
WM
Department of General Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. dychen@yahoo.com
Lei
Shang-tong
ST
Zhang
Qiang
Q
Zhang
Yun-jian
YJ
Wang
Shen-ming
SM
Shi
Han-ping
HP
D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew
D001786:Blood Glucose; D001798:Blood Proteins; D001120:Arginine