Decreases in CD8+ T, naive (CD4+CD45RA+) T, and B (CD19+) lymphocytes by exposure to manganese fume.
To examine the effects of exposure to manganese (Mn) on the cellular and humoral immune system in men, T lymphocyte subpopulations, B (CD19+) lymphocytes, natural killer (NK) cells, and serum immunoglobulins (i.e., IgG, IgA and IgM) together with total T (CD3+) lymphocytes and total lymphocytes were measured in blood samples from 21 welders mainly exposed to Mn fume with blood Mn (BMn) concentrations of 0.6-2.3 (mean 1.4) microg/dl and 21 healthy controls working in the same factory (BMn concentrations: 0.7 to 1.7, mean 1.1 microg/dl). The workers engaged in welding for 6 to 36 (mean 17) yr. All the study subjects were divided into 3 equally sized groups (n=14 for each group) according to BMn concentrations. Numbers of CD8+ T, total T (CD3+), B (CD19+), and total lymphocytes were significantly lower in high-BMn group than those in low-BMn group; the numbers of CD8+ T lymphocytes were significantly lower in moderate-BMn group compared to low-BMn group. After adjusting for age and smoking, significant inverse correlations between BMn concentrations and CD4+CD45RA+ T, CD4+ T, CD8+ T, CD3+ T, and total lymphocytes were found. We conclude that T lymphocytes, especially CD8+ and CD4+CD45RA+ T lymphocytes, as well as CD19+ B lymphocytes are affected by exposure to Mn fume.
Nakata
Akinori
A
National Institute of Occupational Safety and Health, Nagao, Kawasaki, Japan.
Araki
Shunichi
S
Park
Sang-Hwoi
SH
Park
Jong-Tae
JT
Kim
Dae-Sung
DS
Park
Hee-Chan
HC
Yokoyama
Kazuhito
K
D000328:Adult; D018941:Antigens, CD19 / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D006801:Humans; D007723:Korea; D017493:Leukocyte Common Antigens / Q000097:blood*; D008297:Male; D008345:Manganese / Q000633:toxicity*; D008669:Metallurgy; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology; D016273:Occupational Exposure / Q000009:adverse effects*; D010641:Phenotype; D018570:Risk Assessment; D012307:Risk Factors
D018941:Antigens, CD19; D008345:Manganese; D017493:Leukocyte Common Antigens