Interaction partners of the PDZ domain of erbin.
In order to identify proteins that bind to the PDZ domain of Erbin, we tested the C-termini of several proteins in a yeast two-hybrid assay. ErbB2, APC, beta-catenin, c-Rel and HTLV-1 Tax were identified as ligands of the PDZ domain of Erbin. The interactions were verified by co-immunoprecipitation experiments. These findings demonstrate the promiscuity of the PDZ domain of Erbin.
Ress
Angelika
A
Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH-8006 Zurich, Switzerland.
Moelling
Karin
K
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D016356:Gene Products, tax / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D020569:Proto-Oncogene Proteins c-rel / Q000235:genetics / Q000378:metabolism*; D020798:Two-Hybrid System Techniques; D051176:beta Catenin / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D025601:Adenomatous Polyposis Coli Protein; C413364:ERBIN protein, human; D016356:Gene Products, tax; D008024:Ligands; D020569:Proto-Oncogene Proteins c-rel; D051176:beta Catenin