title: Biosynthesis of streptolydigin: origin of the oxygen atoms.
abstract: [Structure: see text] Biosynthetic incorporations of [13C,18O]-labeled precursors into streptolydigin reveal the origin of the oxygen atoms, limiting the possible pathways for acyltetramic acid ring assembly and for formation of the bicyclic ketal.
authors.affiliation: Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4M1, Canada.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Solveig G
authors.initials: SG
authors.lastname: Olesen
authors.forename: Paul H M
authors.initials: PH
authors.lastname: Harrison
mesh_terms: D000617:Aminoglycosides / Q000096:biosynthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism*; D010103:Oxygen Isotopes; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D010103:Oxygen Isotopes; C100307:streptolydigin; D010100:Oxygen