Smoking-responsive juvenile-onset Parkinsonism.
We describe a patient with juvenile levodopa-responsive Parkinsonism who reported a dramatic response to cigarette smoking with transient but marked improvement of motor symptoms associated with oculogyric crises and psychotic behavior. His beta-CIT single-photon emission computed tomography scan showed a complete absence of presynaptic dopaminergic nerve terminals.
Hanagasi
Hasmet Ayhan
HA
Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. hasmet@yahoo.com
Lees
Andrew
A
Johnson
Janel O
JO
Singleton
Andrew
A
Emre
Murat
M
D000328:Adult; D006801:Humans; D008297:Male; D009538:Nicotine / Q000627:therapeutic use*; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012907:Smoking; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes / Q000493:pharmacokinetics
D018722:Nicotinic Agonists; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D009538:Nicotine