Total synthesis of (+/-)-morphine.
[Structure: see text] The morphinan skeleton was effectively synthesized by an intramolecular Mannich-type reaction. Further transformation led to total synthesis of morphine.
Uchida
Kenji
K
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yokoshima
Satoshi
S
Kan
Toshiyuki
T
Fukuyama
Tohru
T
D015394:Molecular Structure; D009020:Morphine / Q000138:chemical synthesis*
D009020:Morphine