title: Lidocaine or diazepam can decrease fasciculation induced by succinylcholine during induction of anesthesia.
abstract: Succinylcholine is used during induction of anesthesia, and it may induce fasciculations. In this study we demonstrated that intravenous diazepam (1 mg/kg) or lidocaine (1.5 mg/kg) can decrease fasciculations induced by succinylcholine. There is no significant difference between these two drugs in reducing fasciculations moreover, these drugs can also prevent raised blood pressure and heart rate during intubation.
authors.affiliation: Tehran University of Medical Sciences, Hassan Abad Square, Sina Hospital, Tehran, Iran. msahrai@sina.tums.ac.ir
authors.forename: Mansour
authors.initials: M
authors.lastname: Hassani
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sahraian
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000379:methods; D018686:Anesthetics, Intravenous / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000627:therapeutic use*; D017558:Elective Surgical Procedures; D005207:Fasciculation / Q000139:chemically induced* / Q000517:prevention & control*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods; D008012:Lidocaine / Q000627:therapeutic use*; D009467:Neuromuscular Depolarizing Agents / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies; D012720:Severity of Illness Index; D013390:Succinylcholine / Q000008:administration & dosage / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D009467:Neuromuscular Depolarizing Agents; D008012:Lidocaine; D013390:Succinylcholine; D003975:Diazepam