Synthesis of cyclic peptides constrained with biarylamine linkers using Buchwald-Hartwig C-N coupling.
In this paper, we describe the synthesis of conformationally constrained cyclic peptides with biarylamine linkers for peptidomimetics using palladium-catalyzed intramolecular Buchwald-Hartwig C-N coupling. We have prepared a variety of di-, tri-, and tetrapeptides (16-22-membered) in good yields using this reaction.
Balraju
V
V
Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500 049, A.P., India.
Iqbal
Javed
J
D000588:Amines / Q000737:chemistry*; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000588:Amines; D010456:Peptides, Cyclic