Epstein-Barr virus in CD30 anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea.
BACKGROUND
Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries.


OBJECTIVE
To elucidate the possible association of EBV with CD30+ anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea.


METHODS
In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving the skin which were selected from six university hospital medical centers in South Korea.


RESULTS
In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30+ ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30+ ALCL with concurrent lymph node involvement. The other was CD30+ ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30+ ALCL.


CONCLUSIONS
LyP and primary cutaneous CD30+ ALCL are very rarely associated with EBV in South Korea.
Kim
You Chan
YC
Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea. maychan@ajou.ac.kr
Yang
Woo Ick
WI
Lee
Min-Geol
MG
Kim
Soo Nam
SN
Cho
Kwang Hyun
KH
Lee
Seok Jong
SJ
Lee
Mi Woo
MW
Koh
Jai Kyoung
JK
D000293:Adolescent; D000328:Adult; D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D017730:Ki-1 Antigen / Q000032:analysis; D007723:Korea; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology* / Q000821:virology; D017731:Lymphomatoid Papulosis / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000235:genetics; D014763:Viral Matrix Proteins / Q000032:analysis
D018951:Antigens, CD20; D017252:CD3 Complex; C037662:EBV-associated membrane antigen, Epstein-Barr virus; C099537:Epstein-Barr virus encoded RNA 1; C106732:Epstein-Barr virus encoded RNA 2; D017730:Ki-1 Antigen; D012367:RNA, Viral; D014763:Viral Matrix Proteins