title: Modafinil and unconstrained motor activity in schizophrenia: double-blind crossover placebo-controlled trial.
abstract: Avolition affects quality of life in chronic schizophrenia. We investigated the effect of modafinil upon unconstrained motor activity in 18 male patients. In a randomised crossover design study, wrist-worn actigraphic monitors were used to objectively record motor activity over a 20 h period. Patients' total activity was significantly greater when given the drug. These data suggest that modafinil increases quantifiable motor behaviour in schizophrenia and may have an impact on avolition.
authors.affiliation: SCANLab, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT, UK. t.f.farrow@sheffield.ac.uk
authors.forename: Tom F D
authors.initials: TF
authors.lastname: Farrow
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hunter
authors.forename: Rozana
authors.initials: R
authors.lastname: Haque
authors.forename: Sean A
authors.initials: SA
authors.lastname: Spence
mesh_terms: D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D000077408:Modafinil; D009043:Motor Activity / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D000077408:Modafinil