title: Chalcone based aryloxypropanolamines as potential antihyperglycemic agents.
abstract: A series of chalcone based aryloxypropanolamines were synthesized and evaluated for their antihyperglycemic activity in SLM and STZ rat models. Most of the compounds exhibited moderate to good activity ranging from 6.5% to 31.1% in SLM and 8.3% to 22.6% in STZ models, respectively. The most potent compound 5 g exhibited glucose lowering of 26.7% in SLM and 22.6% in STZ models. A definite structure-activity relationship was observed while varying the nature as well as the position of the amine in ring B.
authors.affiliation: Central Drug Research Institute, Lucknow, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Shukla
authors.forename: Amar Bahadur
authors.initials: AB
authors.lastname: Singh
authors.forename: Arvind Kumar
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Ram
authors.initials: R
authors.lastname: Pratap
mesh_terms: D000818:Animals; D050150:Chalones / Q000737:chemistry* / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D022702:Receptors, Adrenergic, beta-3 / Q000187:drug effects; D013395:Sucrose / Q000494:pharmacology
chemical_list: D050150:Chalones; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D022702:Receptors, Adrenergic, beta-3; D013395:Sucrose