title: Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica.
abstract: Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins.
authors.affiliation: Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Huizhen
authors.initials: H
authors.lastname: Liu
authors.forename: Kent Gunnertoft
authors.initials: KG
authors.lastname: Jensen
authors.forename: Linh My
authors.initials: LM
authors.lastname: Tran
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Zhai
authors.forename: Carl Erik
authors.initials: CE
authors.lastname: Olsen
authors.forename: Helmer
authors.initials: H
authors.lastname: Søhoel
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Denmeade
authors.forename: John T
authors.initials: JT
authors.lastname: Isaacs
authors.forename: S Brøgger
authors.initials: SB
authors.lastname: Christensen
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000378:metabolism; D053629:Thapsia / Q000737:chemistry*; D019284:Thapsigargin / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010666:Phenylpropionates; D010936:Plant Extracts; D019284:Thapsigargin; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases