[Expression of transforming growth factor beta receptor I and II in chronic rhinosinusitis, nasal polyps and normal nasal mucosa tissues].
OBJECTIVE
To explore the expression of transforming growth factor beta receptor(TGFpR) I, II in the chronic rhinosinusitis, nasal polyps and normal nasal mucosa tissues.


METHODS
The protein expression of the TGFbetaR I and TGFbetaR II were determined by means of immunohistochemistry in chronic rhinosinusitis tissues from 25 patients, nasal polyps tissues from 21 patients and inferior turbinate mucosa tissues from 17 patients with deviation of nasal septum.


RESULTS
(1) In chronic rhinosinusitis and nasal polyps tissues, compared with controls, the expression of TGFbetaR I and TGFbetaR II protein was increased significantly (P < 0.01). (2) The expression of TGFbetaR I and TGFbetaR II protein in nasal polyps tissues was significant increased than that in chronic rhinosinusitis tissues (P < 0.01).


CONCLUSIONS
The different expression level and pattern of TGFbetaR I and TGFbetaR II in chronic rhinosinusitis and nasal polyps tissues indicates TGFbetaR may play a different role in the pathogenesis chronic rhinosinusitis and nasal polyps.
Huang
Linghan
L
Department of Otorhinolaryngology, Tongji Hospital, Huazhong University of Science an Technology, Wuhan, 430030, China.
Liu
Zheng
Z
Lu
Xiang
X
Cui
Yonghua
Y
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D012852:Sinusitis / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II