title: Fat suppression with spectrally selective inversion vs. high spectral and spatial resolution MRI of breast lesions: qualitative and quantitative comparisons.
abstract: OBJECTIVE
  To compare conventional fat-suppressed MR images of the breast to images derived from high spectral and spatial resolution MR data. Image quality and the level of fat suppression are compared qualitatively and quantitatively.
  
  
  METHODS
  Women with suspicious breast lesions found on X-ray mammography were imaged on 1.5 Tesla GE SIGNA scanners. High spectral and spatial resolution (HiSS) data were acquired using echo-planar spectroscopic imaging. Images with intensity proportional to the water signal peak height in each voxel were synthesized. Conventional fat-suppressed images were acquired using a frequency selective inversion method. The experimental (HiSS) and conventional images were compared by experienced radiologists to evaluate the quality of fat suppression. In addition, fat suppression and image quality were evaluated quantitatively.
  
  
  RESULTS
  Fat suppression, tumor edge delineation, lesion conspicuity, and image texture were improved in the peak height images derived from HiSS data.
  
  
  CONCLUSIONS
  The results demonstrate that the water peak height images obtained from HiSS data potentially could improve the quality of fat suppression, detection and diagnosis of breast cancer. HiSS allowed detection of lesions and evaluation of lesion morphology prior to contrast media injection. J. Magn. Reson. Imaging 2006. (c) 2006 Wiley-Liss, Inc.
authors.affiliation: Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fan
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Abe
authors.forename: Milica
authors.initials: M
authors.lastname: Medved
authors.forename: Sean
authors.initials: S
authors.lastname: Foxley
authors.forename: Sanaz
authors.initials: S
authors.lastname: Arkani
authors.forename: Marta A
authors.initials: MA
authors.lastname: Zamora
authors.forename: Olufunmilayo I
authors.initials: OI
authors.lastname: Olopade
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Newstead
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Karczmar
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000465:Algorithms; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique