title: STRING 7--recent developments in the integration and prediction of protein interactions.
abstract: Information on protein-protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The database and online resource STRING generalizes access to protein interaction data, by integrating known and predicted interactions from a variety of sources. The underlying infrastructure includes a consistent body of completely sequenced genomes and exhaustive orthology classifications, based on which interaction evidence is transferred between organisms. Although primarily developed for protein interaction analysis, the resource has also been successfully applied to comparative genomics, phylogenetics and network studies, which are all facilitated by programmatic access to the database backend and the availability of compact download files. As of release 7, STRING has almost doubled to 373 distinct organisms, and contains more than 1.5 million proteins for which associations have been pre-computed. Novel features include AJAX-based web-navigation, inclusion of additional resources such as BioGRID, and detailed protein domain annotation. STRING is available at http://string.embl.de/
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. mering@molbio.unizh.ch
authors.forename: Christian
authors.initials: C
authors.lastname: von Mering
authors.forename: Lars J
authors.initials: LJ
authors.lastname: Jensen
authors.forename: Michael
authors.initials: M
authors.lastname: Kuhn
authors.forename: Samuel
authors.initials: S
authors.lastname: Chaffron
authors.forename: Tobias
authors.initials: T
authors.lastname: Doerks
authors.forename: Beate
authors.initials: B
authors.lastname: Krüger
authors.forename: Berend
authors.initials: B
authors.lastname: Snel
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
mesh_terms: D030562:Databases, Protein / Q000592:standards; D020407:Internet; D025941:Protein Interaction Mapping; D017386:Sequence Homology, Amino Acid; D018511:Systems Integration; D014584:User-Computer Interface