title: Recognition of transmembrane segments in proteins: review and consistency-based benchmarking of internet servers.
abstract: Membrane proteins perform a number of crucial functions as transporters, receptors, and components of enzyme complexes. Identification of membrane proteins and prediction of their topology is thus an important part of genome annotation. We present here an overview of transmembrane segments in protein sequences, summarize data from large-scale genome studies, and report results of benchmarking of several popular internet servers.
authors.affiliation: Institute for Information Transmission Problems, Russian Academy of Science, Bolshoi Karetny per. 19, Moscow 127994, Russia. nathalie@ippi.ru
authors.forename: Nataliya S
authors.initials: NS
authors.lastname: Sadovskaya
authors.forename: Roman A
authors.initials: RA
authors.lastname: Sutormin
authors.forename: Mikhail S
authors.initials: MS
authors.lastname: Gelfand
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D019985:Benchmarking; D002462:Cell Membrane / Q000737:chemistry*; D020407:Internet; D008565:Membrane Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020539:Sequence Analysis, Protein / Q000379:methods* / Q000592:standards; D012986:Software Validation
chemical_list: D008565:Membrane Proteins