Kleine-Levin syndrome in a 14-year-old girl: CSF hypocretin-1 measurements.
CSF hypocretin-1 measurements were performed during a period of hypersomnia and during an asymptomatic interval in a 14-year-old girl affected with severe Kleine-Levin syndrome. A twofold decrease in hypocretin-1 was evidenced during the period of hypersomnia in comparison with the asymptomatic interval. Together with previous data, this result is in favour of recurrent dysfunction at the hypothalamic level in Kleine-Levin syndrome.
Podestá
Claudio
C
Department of Neurology FLENI, Sleep Laboratory, Buenos-Aires, Argentina. cpodesta@fleni.org.ar
Ferreras
Mónica
M
Mozzi
Marcela
M
Bassetti
Claudio
C
Dauvilliers
Yves
Y
Billiard
Michel
M
D000293:Adolescent; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D017593:Kleine-Levin Syndrome / Q000134:cerebrospinal fluid*; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins
C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins