title: Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate.
abstract: A spectroscopic assay based on surface enhanced Raman scattering (SERS) using silver nanorod array substrates has been developed that allows for rapid detection of trace levels of viruses with a high degree of sensitivity and specificity. This novel SERS assay can detect spectral differences between viruses, viral strains, and viruses with gene deletions in biological media. The method provides rapid diagnostics for detection and characterization of viruses generating reproducible spectra without viral manipulation.
authors.affiliation: Department of Chemistry, Physics and Astronomy and Center for Disease Intervention, Department of Infectious Diseases, University of Georgia, Athens, Georgia 30602, USA.
authors.forename: Saratchandra
authors.initials: S
authors.lastname: Shanmukh
authors.forename: Les
authors.initials: L
authors.lastname: Jones
authors.forename: Jeremy
authors.initials: J
authors.lastname: Driskell
authors.forename: Yiping
authors.initials: Y
authors.lastname: Zhao
authors.forename: Richard
authors.initials: R
authors.lastname: Dluhy
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Tripp
mesh_terms: D017353:Gene Deletion; D006801:Humans; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry*; D012015:Reference Standards; D018113:Respiratory Syncytial Virus, Human / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods* / Q000592:standards; D013499:Surface Properties
chemical_list: D012834:Silver