Reverse thermal gelation of aliphatically modified biodegradable triblock copolymers.
A simple aliphatic modification demonstrated how to turn a water-soluble biodegradable triblock copolymer synthesized from PEG, L-lactide, and epsilon-caprolactone into a thermoreversible polymer of which aqueous solution underwent a sol-to-gel phase transition upon a mild temperature rise. Thermogelling behavior of the aliphatically modified polymer was dependent on the degree of aliphatic modification and polymer concentration. When the polymer solutions were subcutaneously injected into rats, immediate depot formation has been observed. The polymeric gel depots have lasted for two weeks in vivo. This aliphatically modified thermogelling polymer can find applications in drug delivery.
Jo
Seongbong
S
Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, 30 S 2000 E RM 201, University of Utah, Salt Lake City, UT 84112-5820, USA.
Kim
Jin
J
Kim
Sung Wan
SW
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D001672:Biocompatible Materials; D005227:Fatty Acids; D011108:Polymers; D011092:Polyethylene Glycols