hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among Japanese.
BACKGROUND
The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC).


METHODS
We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC.


RESULTS
Overall, the hOGG1 genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69).


CONCLUSIONS
These results suggest that the hOGG1 Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis.
Sakamoto
Tatsuhiko
T
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga. sakamott@med.saga-u.ac.jp
Higaki
Yasuki
Y
Hara
Megumi
M
Ichiba
Masayoshi
M
Horita
Mikako
M
Mizuta
Toshihiko
T
Eguchi
Yuichiro
Y
Yasutake
Tsutomu
T
Ozaki
Iwata
I
Yamamoto
Kyosuke
K
Onohara
Shingo
S
Kawazoe
Seiji
S
Shigematsu
Hirohisa
H
Koizumi
Shunzo
S
Tanaka
Keitaro
K
D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012694:Serine / Q000235:genetics
D012694:Serine; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human