Reproduction of severe gastroesophageal ulcers (GEU) in gnotobiotic swine infected with porcine Helicobacter pylori-like bacteria.
Groups of gnotobiotic piglets were orally inoculated at 3 days of age with either Helicobacter heilmannii (Hh) or a newly described porcine-origin gastric Helicobacter pylori (Hp)-like bacterium. Three Hh-infected and 6 porcine Hp-like-infected swine were fed a milk replacement diet containing 5-10% (v/v) sterile corn syrup as a dietary source of fermentable carbohydrate. None of the piglets infected with Hh and supplemented with corn syrup developed gastric mucosal ulcers; 2 developed small erosive lesions in the pars esophagea. In contrast, all 6 dietary carbohydrate-supplemented Hp-like-infected swine developed severe gastroesophageal ulcers; 1 of these ex-sanguinated into the stomach and died before the end of the experiment. Four of these 6 piglets had grossly evident partially digested blood in the intestinal lumens, indicative of bleeding into the gastrointestinal tract from the stomach. These data suggest that a high carbohydrate diet and gastric colonization by porcine Hp-like bacteria facilitate development of clinically significant gastroesophageal ulcers.
Krakowka
S
S
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA.
Ellis
J
J
D000818:Animals; D004935:Esophageal Diseases / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D004943:Esophagogastric Junction / Q000382:microbiology* / Q000473:pathology; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005856:Germ-Free Life; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016480:Helicobacter pylori / Q000145:classification*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology* / Q000473:pathology; D014456:Ulcer / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*