Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer.
We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P<0.001). Furthermore, median intra- and perinodal lymphatic endothelial cell proliferation fractions were higher in metastatically involved LNs (P<0.001). This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in general and breast cancer in particular.
Van den Eynden
G G
GG
Translational Cancer Research Group Antwerp (Lab Pathology University Antwerp/University Hospital Antwerp, Edegem; Oncology Center, General Hospital St-Augustinus, Wilrijk), Antwerp, Belgium.
Van der Auwera
I
I
Van Laere
S J
SJ
Huygelen
V
V
Colpaert
C G
CG
van Dam
P
P
Dirix
L Y
LY
Vermeulen
P B
PB
Van Marck
E A
EA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D015415:Biomarkers / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000556:secondary*; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000556:secondary; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D008562:Membrane Glycoproteins / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen; D000098853:Podoplanin
D015415:Biomarkers; D008562:Membrane Glycoproteins; D011960:Receptors, Estrogen; C117468:PDPN protein, human; D000098853:Podoplanin