Corneal topographic features in a family with nanophthalmos.
OBJECTIVE
To characterize the corneal topographic features in a family with nanophthalmos.


METHODS
Two observational case reports and a review of the literature. Corneal shape was analyzed using a topographic modeling system (TMS) and an Orbscan topographic system, with further analysis based on Fourier series and Zernicke polynomials. A control group was used for comparison.


RESULTS
Two female family members with nanophthalmos belonging to the same generation showed significant irregular corneal astigmatism and corneal steepening.


CONCLUSIONS
Topographic corneal steepening and irregular astigmatism seems to be associated in 1 family with inherited nanophthalmos. Higher degrees of irregular astigmatism, which were not evident without a topographic analysis, may account, in part, for the unexplained visual reduction.
Srinivasan
Sathish
S
Department of Ophthalmology, Aintree University Hospitals, Liverpool, United Kingdom. sathish.srinivasan@gmail.com
Batterbury
Mark
M
Marsh
Ian B
IB
Fisher
Anthony C
AC
Willoughby
Colin
C
Kaye
Stephen B
SB
D000368:Aged; D001251:Astigmatism / Q000175:diagnosis* / Q000235:genetics; D003315:Cornea / Q000002:abnormalities / Q000473:pathology*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D008850:Microphthalmos / Q000175:diagnosis* / Q000235:genetics; D008875:Middle Aged; D010375:Pedigree; D014786:Vision Disorders / Q000175:diagnosis / Q000235:genetics; D014792:Visual Acuity