[Advances of research on abnormality of cell immunity in idiopathic thrombocytopenic purpura: review].
It was long believed that platelets are prematurely destroyed in the reticuloendothelial system by platelet autoantibodies in idiopathic thrombocytopenic purpura. However, humoral mechanisms cannot account for all observations made in this disorder, and it is increasingly evident that cellular mechanisms contribute to platelet destruction. In this review the tolerance of T cell, abnormality of T cell apoptosis, abnormal activation of T cells, T cell subtype and its function changes, and T cell-mediated cytotoxicity were summarized.
Zhao
Chun-Hong
CH
Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China.
Hou
Ming
M
D017209:Apoptosis / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular / Q000276:immunology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D001323:Autoantibodies