Dopamine and adult neurogenesis.
Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we approach a highly controversial question: can the adult human brain use neurogenesis to replace the dopaminergic neurones in the substantia nigra that are lost in Parkinson's disease?
Borta
Andreas
A
Experimental Neurology, Philipps University, Marburg, Germany.
Höglinger
Günter U
GU
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D013234:Stem Cells / Q000378:metabolism*; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism / Q000503:physiopathology
D004298:Dopamine