fRNAdb: a platform for mining/annotating functional RNA candidates from non-coding RNA sequences.
There are abundance of transcripts that code for no particular protein and that remain functionally uncharacterized. Some of these transcripts may have novel functions while others might be junk transcripts. Unfortunately, the experimental validation of such transcripts to find functional non-coding RNA candidates is very costly. Therefore, our primary interest is to computationally mine candidate functional transcripts from a pool of uncharacterized transcripts. We introduce fRNAdb: a novel database service that hosts a large collection of non-coding transcripts including annotated/non-annotated sequences from the H-inv database, NONCODE and RNAdb. A set of computational analyses have been performed on the included sequences. These analyses include RNA secondary structure motif discovery, EST support evaluation, cis-regulatory element search, protein homology search, etc. fRNAdb provides an efficient interface to help users filter out particular transcripts under their own criteria to sort out functional RNA candidates. fRNAdb is available at http://www.ncrna.org/
Kin
Taishin
T
Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology (AIST) Aomi 2-42, Koto-ku, Tokyo 135-0064, Japan. kin-taushin@aist.go.jp
Yamada
Kouichirou
K
Terai
Goro
G
Okida
Hiroaki
H
Yoshinari
Yasuhiko
Y
Ono
Yukiteru
Y
Kojima
Aya
A
Kimura
Yuki
Y
Komori
Takashi
T
Asai
Kiyoshi
K
D001483:Base Sequence; D030561:Databases, Nucleic Acid; D023281:Genomics; D020407:Internet; D035683:MicroRNAs / Q000502:physiology; D012333:RNA, Messenger / Q000737:chemistry; D022661:RNA, Untranslated / Q000737:chemistry* / Q000502:physiology; D014584:User-Computer Interface
D035683:MicroRNAs; D012333:RNA, Messenger; D022661:RNA, Untranslated