Survey of the patients with cleft lip and palate in China who were funded for surgery by the Smile Train Program from 2000 to 2002.
BACKGROUND
Cleft lip (CL) and cleft palate (CP) are two of the most frequent congenital malformations. Many epidemiologic studies on this deformity have been conducted worldwide, often producing inconsistent results. This study assessed epidemiology and some genetic aspects of cleft lip and palate in a Chinese sample from the Smile Train Program and to compare with other methodologically sound surveys.


METHODS
The general information, family history, classification of cleft and associated malformations of 8000 CL and CP surgery patients were analyzed.


RESULTS
Of the 8000 cases, 7812 had complete data. The distribution of cleft types is 17.04% with CP, 23.39% with CL and 59.58% with cleft lip and palate (CLP). Unilateral clefts were more common than bilateral, with unilateral to bilateral ratios being 10.4:1 for CL, and 3.42:1 for CLP. The overall male:female ratio was 2.01:1. Left sided defects were more common than right sided regardless of sex, 1.90:1 for CL and 1.96:1 for CLP. CLP and CL were more common in males than in females with sex ratios (SR) of 2.88:1 and 1.85:1 respectively, whereas CP was more common in females with SR of 0.76:1. Associated malformations (2.89%), involved 29 CP cases, 41 CL and 156 CLP. The frequency of associated malformations in CLP (3.35%) was higher than CL (2.24%) and CP (2.22%) (P < 0.05). Patients with CP or CLP were born less often in the winter than in the summer (P < 0.05). A history of family members having clefts occurred in 6.84% of patients. The proportion of CLP cases (7.56%) was significantly higher than that of CL cases (5.64%) (P < 0.05).


CONCLUSIONS
The different types of clefts appeared in the highest proportion in CLP and lowest proportion in CP. Males are more common with CL and CLP and less common with CP. These characteristics are the same as those of other Chinese surveys but different from some European reports.
Zhou
Qiao-juan
QJ
Department of Oral and Maxillofacial Surgery, West China Dental School, Sichuan University, Chengdu 610041, China.
Shi
Bing
B
Shi
Zong-dao
ZD
Zheng
Qian
Q
Wang
Yan
Y
D002681:China / Q000453:epidemiology; D002971:Cleft Lip / Q000453:epidemiology* / Q000235:genetics / Q000601:surgery; D002972:Cleft Palate / Q000453:epidemiology* / Q000235:genetics / Q000601:surgery; D005260:Female; D007839:Functional Laterality; D006306:Health Surveys; D006801:Humans; D008297:Male; D012737:Sex Factors; D013997:Time Factors