title: [SNP polymorphism of LGALS3BP gene in patients with benign and malignant thyroid tumours].
abstract: BACKGROUND
  The aim of the study was estimation of occurrence of SNP (single nucleotide polymorphism) sites in LGALS3BP gene in patients with benign and malignant thyroid tumors and analysis of correlation between their frequency and the histological type of thyroid lesions.
  
  
  METHODS
  The studied group consisted of 58 patients, 24 with papillary thyroid carcinomas, 19 with nodular goiters and 15 with follicular adenomas. Control group included 180 healthy volunteers. Four different SNP polymorphisms were analysed in PCR products using the SNaPshot test, on genetic analyser ABI Prism 310; these can be found in NCBI database under rs numbers: 1803938 (a/g), 11024 (g/c), 1801463 (a/c) and 1131516 (c/t).
  
  
  RESULTS
  In all patients analysis of SNP sites revealed: lack of polymorphism in a/g rs 18039380; polymorphism identical to database in g/c rs 11024 and polymorphism different from database in a/g rs 1801463 and c/g rs 131516. There were no significant differences between patients with thyroid lesions and group of healthy controls.
  
  
  CONCLUSIONS
  Single nucleotide polymorphism (SNP) of LGALS3BP gene (found in NCBI) database are not characteristic for papillary thyroid cancer, follicular adenomas and nodular goiter.
authors.affiliation: I Department of General, Gastroenterologicaland Endocrinological Surgery, Faculty of Public Health, Medical University Wroclaw, J. Poniatowskiego 2, Wroclaw.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Łukieńczuk
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kaliszewski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zołedziewska
authors.forename: Anna
authors.initials: A
authors.lastname: Jonkisz
authors.forename: Grazyna
authors.initials: G
authors.lastname: Dmochowska
authors.forename: Mirosław
authors.initials: M
authors.lastname: Dobrut
authors.forename: Jacek
authors.initials: J
authors.lastname: Rogoliński
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Dobosz
mesh_terms: D000236:Adenoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006023:Glycoproteins / Q000235:genetics*; D006044:Goiter, Nodular / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013964:Thyroid Neoplasms / Q000235:genetics*; D016326:Extracellular Matrix Proteins
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D006023:Glycoproteins; C081856:LGALS3BP protein, human; D016326:Extracellular Matrix Proteins