CoREST-like complexes regulate chromatin modification and neuronal gene expression.
The mammalian CoREST ([co]repressor for element-1-silencing transcription factor) complex was first identified associated with the repressor for element-1 silencing transcription factor (REST)/neuronal restrictive silencing factor. The CoREST complex is a chromatin-modifying corepressor complex that acts with REST to regulate neuronal gene expression and neuronal stem cell fate. Components of a CoREST-like complex have been identified recently in Xenopus laevis, Caenorhabditis elegans, and Drosophila melanogaster. Like the mammalian complex, the Drosophila complex is required to regulate neuronal gene expression, whereas the C. elegans homologs regulate the expression of the hop-1 presenilin gene, suggesting an ancient conserved function of CoREST complexes in regulating neuronal gene expression.
Lakowski
Bernard
B
Nematode Genetics Group, Department of Neuroscience, Pasteur Institute, 75724 Paris Cedex 15, France. lakowski@pasteur.fr
Roelens
Ingele
I
Jacob
Sandrine
S
D000818:Animals; D029681:Arabidopsis Proteins / Q000502:physiology; D005075:Biological Evolution; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D018797:Cell Cycle Proteins; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006609:High Mobility Group Proteins / Q000502:physiology; D056284:Histone Deacetylase 1; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases / Q000502:physiology; D056466:Histone Demethylases; D006801:Humans; D007448:Invertebrates / Q000235:genetics / Q000378:metabolism; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D051379:Mice; D046912:Multiprotein Complexes / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D009474:Neurons / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000502:physiology; D011401:Promoter Regions, Genetic; D019908:Proto-Oncogene Proteins c-raf / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology; D000099229:RE1-Silencing Transcription Factor
D029681:Arabidopsis Proteins; D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D002843:Chromatin; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006609:High Mobility Group Proteins; D056284:Histone Deacetylase 1; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases; D056466:Histone Demethylases; D046912:Multiprotein Complexes; D009419:Nerve Tissue Proteins; D010089:Oxidoreductases, N-Demethylating; D019908:Proto-Oncogene Proteins c-raf; D012097:Repressor Proteins; D014157:Transcription Factors; D000099229:RE1-Silencing Transcription Factor; C000625244:HMG20B protein, human; C400291:Hmg20b protein, mouse; C492635:Phf21a protein, mouse; C121019:RCOR1 protein, human; C504076:KDM1a protein, mouse; C495195:KDM1A protein, human; C468848:SPR-5 protein, C elegans; C492634:PHF21A protein, human; C110550:HDAC1 protein, human; C484389:Hdac1 protein, mouse; C533424:Hdac2 protein, mouse