Animal models of pheochromocytoma including NIH initial experience.
Mouse models have been used to study the mechanisms underlying the carcinogenesis of a wide variety of human cancer. A considerable number of mouse and rat models, used for the study of elementary tumorgenic mechanisms, were found to develop pheochromocytomas. Some of these models resemble hereditary syndrome-related pheochromocytoma in humans and some may serve as a new starting point for human pheochromocytoma research. Recently, we generated a model of catecholamine-producing metastatic pheochromocytoma in athymic nude mice using tail-vein injection of mouse pheochromocytoma cells (MPCs). This and alternative animal models of metastatic pheochromocytoma are promising avenues in preclinical studies to evaluate new therapeutic approaches for malignant pheochromocytoma.
Ohta
Shoichiro
S
Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, NIH, Building 10, CRC, Room 1E-3141, 10 Center Drive MSC-1109, Bethesda, MD 20892-1109, USA.
Lai
Edwin W
EW
Taniguchi
Shun'Ichiro
S
Tischler
Arthur S
AS
Alesci
Salvatore
S
Pacak
Karel
K
D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D009316:National Institutes of Health (U.S.); D010673:Pheochromocytoma / Q000473:pathology*; D014481:United States