Design and in vitro evaluation of polymeric formulae of simvastatin for local bone induction.
Simvastatin (SVS), a cholesterol-lowering drug, has been shown to stimulate bone formation. This study deals with the design and in vitro evaluation of local delivery systems for simvastatin. They are intended to treat bony defects resulting from periodontitis or to induce osteogenesis around the titanium implants. Granules and gels were formulated using bioerodible/biocompatible polymers, namely hydroxypropylmethyl cellulose (H), sodium carboxymethyl cellulose (C), and chitosan (Ch). The in vitro release profiles and kinetics were evaluated and the swelling and/or erosion was monitored. Differential scanning calorimetry (DSC) and infrared (IR) were used to detect any SVS/polymer interactions that may affect drug release. The results revealed variable extents of controlled drug release from the designed formulae depending on the polymer nature. About 50% cumulative SVS was released from both H granules and gel formulae within 24 h and approximately 66% and approximately 88% from C granules and gel, respectively. Ch formulae exhibited approximately 50% release from granules and approximately 30% from gel.
Ismail
Fatma A
FA
Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt. fatmaismail@yahoo.com
D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry; D001704:Biopolymers / Q000008:administration & dosage / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D015195:Drug Design; D005782:Gels; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D010316:Particle Size; D010518:Periodontitis / Q000188:drug therapy; D019821:Simvastatin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
D001672:Biocompatible Materials; D001704:Biopolymers; D005782:Gels; D019821:Simvastatin