title: Modern aldol methods for the total synthesis of polyketides.
abstract: The aldol reaction is one of the most important methods for the stereoselective construction of polyketide natural products, not only for nature but also for synthetic chemistry. The tremendous development in the field of aldol additions during the last 30 years has led to more and more total syntheses of complicated natural products. This Review illustrates by means of selected syntheses of natural products the new variants of the aldol addition. This includes aldol additions with various metal enolates, as well as metal-complex-catalyzed, organocatalytic, and biocatalytic methods.
authors.affiliation: Chemisches Institut, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Schetter
authors.forename: Rainer
authors.initials: R
authors.lastname: Mahrwald
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001895:Boron / Q000737:chemistry; D002384:Catalysis; D004917:Erythromycin / Q000138:chemical synthesis; D018942:Macrolides / Q000138:chemical synthesis*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D018942:Macrolides; D009942:Organometallic Compounds; D004917:Erythromycin; C116609:3-hydroxybutanal; D001895:Boron