title: The relationship between transmural extent of infarction on contrast enhanced magnetic resonance imaging and recovery of contractile function in patients with first myocardial infarction treated with thrombolysis.
abstract: BACKGROUND
  The aim of the current study was to assess the utility of transmurality of delayed enhancement on cardiac magnetic resonance imaging (MRI) in predicting functional recovery in patients with first ST-elevation myocardial infarction (MI) who had received thrombolysis.
  
  
  METHODS
  Nineteen patients underwent cine and contrast-enhanced MRI 3 days and 8 weeks after MI. The transmural extent of infarction (TEI) was determined from the late enhancement component of the first scan. Segmental wall thickening was scored from the cine components of both the initial and follow-up scans.
  
  
  RESULTS
  The TEI was inversely related to the likelihood of improvement in wall thickening; chi(2) test for trend = 53.9, p < 0.0001. Delayed enhancement with >50% transmurality predicted a lack of recovery with 82% sensitivity and 54% specificity. The equivalent values for >75% transmurality were 57 and 77%, respectively. The proportion of the left ventricular segments exhibiting functional recovery was related to the percentage of the left ventricle that was severely dysfunctional but had <or=50% TEI (r = 0.49, p = 0.03). In a backward conditional regression model this was the only independent predictor.
  
  
  CONCLUSIONS
  These data suggest that TEI, determined by contrast-enhanced cardiac MRI, is a useful predictor of the likelihood, or otherwise, of functional recovery following acute MI treated with thrombolysis.
authors.affiliation: Department of Cardiology, Aberdeen Royal Infirmary, Aberdeen, UK.
authors.forename: Justin L
authors.initials: JL
authors.lastname: Barclay
authors.forename: Mohaned
authors.initials: M
authors.lastname: Egred
authors.forename: Kirsten
authors.initials: K
authors.lastname: Kruszewski
authors.forename: Ramasami
authors.initials: R
authors.lastname: Nandakumar
authors.forename: Murdoch Y
authors.initials: MY
authors.lastname: Norton
authors.forename: Colin
authors.initials: C
authors.lastname: Stirrat
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Redpath
authors.forename: Stephen
authors.initials: S
authors.lastname: Walton
authors.forename: Graham S
authors.initials: GS
authors.lastname: Hillis
mesh_terms: D000368:Aged; D003287:Contrast Media; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000188:drug therapy*; D011237:Predictive Value of Tests; D020127:Recovery of Function
chemical_list: D003287:Contrast Media; D005343:Fibrinolytic Agents