Levels of serologic markers of celiac disease in patients with reflux esophagitis.
OBJECTIVE
To investigate the prevalence of celiac disease serologic markers (antigliadin IgA, IgG, and anti-endomysial IgA) in patients with reflux esophagitis and to detect the relationship between reflux esophagitis and celiac disease (CD).


METHODS
This study was performed prospectively between January 2003 and January 2004. Sixty-eight adult reflux esophagitis patients and 40 people as control group for symptoms related with gastrointestinal system were enrolled in this study. The diagnostic work-up included an accurate medical history with gastrointestinal symptoms, routine laboratory measurements, the detection of antibodies against gliadin (IgA and IgG) and endomysium (IgA), and an upper endoscopy with postbulbar biopsy.


RESULTS
IgA-AGA and IgG-AGA were positive at 8.8% and 10.3% in patients with reflux esophagitis. In control group, it was found that 10% people had positive IgA-AGA, and 7.5% people had positive IgG-AGA. There was no significant relationship between patients and control group regarding positive IgA-AGA and IgG-AGA. The patients and persons in control group had no positive IgA-EMA. On postbulbar biopsies, no finding was detected concerning celiac disease. There were no symptoms and signs for gluten enteropathy in patients and control group.


CONCLUSIONS
This review supports that an association does not exist between celiac disease and reflux esophagitis. We think these diseases exist independently from each other.
Bagci
Sait
S
Department of Gastroenterology, Gulhane School of Medicine, Etlik 06018 - Ankara, Turkey.
Ercin
C Nuri
CN
Yesilova
Zeki
Z
Ozcan
Ayhan
A
Degertekin
Bulent
B
Dagalp
Kemal
K
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood* / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D004942:Esophagitis, Peptic / Q000097:blood* / Q000150:complications; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood* / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin