Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina.
To provide a foundation for the development of effective interventions to counteract various age-related diseases in humans, ageing processes have been extensively studied in various model organisms and systems. However, the mechanisms underlying ageing are still not unravelled in detail in any system including rather simple organisms. In this article, we review some of the molecular mechanisms that were found to affect ageing in two fungal models, the unicellular ascomycete Saccharomyces cerevisiae and the filamentous ascomycete Podospora anserina. A selection of issues like retrograde response, genomic instability, caloric restriction, mtDNA reorganisation and apoptosis is presented and discussed with special emphasis on the role reactive oxygen species (ROS) play in these diverse molecular pathways.
Osiewacz
Heinz D
HD
Institute of Molecular Biosciences, Molecular Developmental Biology, Johann Wolfgang Goethe University, Frankfurt, Germany. osiewacz@em.uni-frankfurt.de
Scheckhuber
Christian Q
CQ
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D016922:Cellular Senescence / Q000187:drug effects / Q000502:physiology; D004272:DNA, Mitochondrial / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins; D008954:Models, Biological; D010088:Oxidoreductases / Q000096:biosynthesis; D010940:Plant Proteins; D048468:Podospora / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D000099188:Alternative Oxidase
D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins; D010088:Oxidoreductases; D010940:Plant Proteins; D017382:Reactive Oxygen Species; D000099188:Alternative Oxidase