Acitretin induces capillary leak syndrome in a patient with pustular psoriasis.
Capillary leak syndrome is a rare and potentially life-threatening condition caused by a shift of intravascular fluid and proteins to the interstitial space. We describe a patient with pustular psoriasis in whom capillary leak syndrome developed after the start of acitretin. Immediate withdrawal of retinoic acid is necessary and corticosteroid therapy should be considered.
Vos
Lydia E
LE
Department of Dermatology, Leiden University Medical Center, The Netherlands. l.e.vos@lumc.nl
Vermeer
Maarten H
MH
Pavel
Stan
S
D017255:Acitretin / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D019559:Capillary Leak Syndrome / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D004417:Dyspnea / Q000209:etiology; D004487:Edema / Q000209:etiology; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy*
D007641:Keratolytic Agents; D017255:Acitretin