Calcium-phosphorus product and troponin-T values in renal failure.
OBJECTIVE
The purpose of this study was to see if there is a significant association between calcium-phosphorus product (CPP) and initial troponin-T values in patients with renal insufficiency.


METHODS
A retrospective study over 4 months from the laboratory database of all patients with serum creatinine values greater than 3 mg/dL who had concomitant troponin T and creatine kinase isoenzymes measured was conducted. The most recent calcium and phosphorus values were also abstracted.


RESULTS
There were 87 patients with a mean age of 59 years, a median creatinine value of 51 mg/dL, a mean CPP of 47, and a median initial troponin-T value of 0.18 ng/mL. The troponin level was elevated (>0.05 ng/mL) in 74% of the patients. The CPP was higher than 55 in 28% of the patients. When comparing the troponin values with the CPP, there was no association noted (P = .72).


CONCLUSIONS
Although both elevated CPP and troponin values are associated with increased cardiovascular mortality in the intermediate term, we could not demonstrate a useful relationship between the 2 values that would indicate causality or help with the interpretation of the initial troponin level when patients with renal insufficiency present with suspected acute myocardial infarction.
Wrenn
Keith
K
Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, TN 7232-4700, USA. keith.wrenn@vanderbilt.edu
Blair
Robert
R
Parl
Fritz F
FF
Schleicher
RuAnn
R
D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood*; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood* / Q000201:enzymology / Q000628:therapy; D012189:Retrospective Studies; D020107:Troponin T / Q000097:blood*
D020107:Troponin T; D010758:Phosphorus; D003404:Creatinine; D052279:Creatine Kinase, MB Form; D002118:Calcium