title: Contrast enhancement by feedback fields in magnetic resonance imaging.
abstract: A conceptually new approach giving rise to contrast enhancement by feedback fields in magnetic resonance imaging is proposed, and the detailed mechanism is described. Nonlinear spin dynamics under the feedback fields of the distant dipolar field and/or radiation damping are examined and shown to amplify contrast due to small variations in spin density and precession frequency. Feedback-based contrast enhancement depends on the instability of the initial magnetization configuration and is propagated by positive feedback, as shown through numerical simulations and experimental results on simple phantom samples. On the basis of a theoretical understanding of contrast enhancement, insight into pulse sequence design and optimal contrast attainable under the individual and joint feedback fields is provided.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
authors.forename: Sandip
authors.initials: S
authors.lastname: Datta
authors.forename: Susie Y
authors.initials: SY
authors.lastname: Huang
authors.forename: Yung-Ya
authors.initials: YY
authors.lastname: Lin
mesh_terms: D003287:Contrast Media; D005246:Feedback; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging
chemical_list: D003287:Contrast Media