Voltage-gated sodium channels: action players with many faces.
Voltage-gated sodium channels are responsible for the upstroke of the action potential and thereby play an important role in propagation of the electrical impulse in excitable tissues like muscle, nerve and the heart. Duplication of the sodium channels encoding genes during evolution generated the sodium channel gene family with the different isoforms differing in biophysical properties and tissue distribution. In this review article, mutations in these genes leading to various inherited disorders are discussed.
Koopmann
Tamara T
TT
Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. T.T.Koopmann@amc.uva.nl
Bezzina
Connie R
CR
Wilde
Arthur A M
AA
D000818:Animals; D001927:Brain Diseases / Q000235:genetics; D053447:Channelopathies / Q000150:complications / Q000235:genetics*; D006331:Heart Diseases / Q000235:genetics; D006801:Humans; D015640:Ion Channel Gating / Q000235:genetics* / Q000502:physiology; D051379:Mice; D009135:Muscular Diseases / Q000235:genetics; D009154:Mutation / Q000235:genetics; D015222:Sodium Channels / Q000235:genetics* / Q000502:physiology
D015222:Sodium Channels