title: Dynamics of pituitary down-regulation and ovarian response to controlled stimulation in in vitro fertilization cycles.
abstract: The effect of the daily GnRH agonist administration on LH levels and ovarian response after down-regulation was investigated in 2 groups of women who received recombinant FSH versus hMG. The results showed that the pituitary gland remained responsive to the daily buserelin by producing pulses of LH, despite down-regulation in both groups; however, the patients whose condition is profoundly down-regulated may need exogenous LH to improve their response.
authors.affiliation: Centres for Assisted Reproduction (CARE Fertility), Cliftonville, Northampton, United Kingdom. kamel.mohamed@ntlworld.com <kamel.mohamed@ntlworld.com>
authors.forename: Kamel Abdelhakim
authors.initials: KA
authors.lastname: Mohamed
authors.forename: W A R
authors.initials: WA
authors.lastname: Davies
authors.forename: Hany
authors.initials: H
authors.lastname: Lashen
mesh_terms: D000328:Adult; D002064:Buserelin / Q000008:administration & dosage*; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002064:Buserelin