Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342.
Two new furopyrrols, designated tensidols A and B, were isolated from the culture broth of Aspergillus niger FKI-2342 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated and shown to have the common skeleton of 6-benzyl-6H-furo[2,3-b]pyrrole. Tensidols A and B potentiated miconazole activity against Candida albicans. Tensidols also showed moderate antimicrobial activity only against Pyricularia oryzae.
Fukuda
Takashi
T
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Hasegawa
Yoko
Y
Hagimori
Keiichi
K
Yamaguchi
Yuichi
Y
Masuma
Rokuro
R
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004357:Drug Synergism; D005285:Fermentation; D005663:Furans / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000494:pharmacology; D013501:Surface-Active Agents
D000935:Antifungal Agents; D005663:Furans; D011758:Pyrroles; D013501:Surface-Active Agents; C515289:tensidol A; C515288:tensidol B; D008825:Miconazole