title: Cannabis use in patients with multiple sclerosis.
abstract: BACKGROUND
  Little is known about the extent and patterns of cannabis use in people with multiple sclerosis (MS).
  
  
  METHODS
  MS patients attending neurology outpatient clinics at two hospitals in London and one in Kent, UK completed a questionnaire.
  
  
  RESULTS
  Questionnaires were completed by 254/337 (75%) MS patients. Forty-three per cent had used cannabis at some stage (ever users). Of these, 68% (75/110) had used cannabis to alleviate symptoms of MS (MS-related cannabis use). Forty-six (18%) had used cannabis in the last month (current users), of whom 12% (31/254) had used it for symptom relief. Being married or having a long-term partner, tobacco smokers and increasing disability were independent risk factors for MS-related cannabis use. Compared to patients who could walk unaided, cannabis use was more likely in those who were chair-bound (adjusted OR 2.47; 1.10-5.56) or only able to walk with an aid (adjusted OR 1.56; 0.90-3.60). Pain and spasms were common reasons for cannabis use. Seventy-one per cent of individuals who had never used cannabis said they would try the drug if it were available on prescription.
  
  
  CONCLUSIONS
  A large proportion of MS patients had tried cannabis for symptom control, however current use was small. A subgroup with greater disability appears to derive some symptomatic benefit.
authors.affiliation: Department of Neurology, Kings College Hospital NHS Trust, London, UK.
authors.forename: M S
authors.initials: MS
authors.lastname: Chong
authors.forename: K
authors.initials: K
authors.lastname: Wolff
authors.forename: K
authors.initials: K
authors.lastname: Wise
authors.forename: C
authors.initials: C
authors.lastname: Tanton
authors.forename: A
authors.initials: A
authors.lastname: Winstock
authors.forename: E
authors.initials: E
authors.lastname: Silber
mesh_terms: D000328:Adult; D000368:Aged; D002188:Cannabis / Q000009:adverse effects; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000523:psychology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000523:psychology*; D008517:Phytotherapy / Q000706:statistics & numerical data; D028321:Plant Preparations / Q000009:adverse effects / Q000627:therapeutic use; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D028321:Plant Preparations