title: Metabolism and depletion of albendazole in the muscle tissue of channel catfish following oral treatment.
abstract: The residue depletion of albendazole (ABZ) and its metabolites was studied in channel catfish muscle tissue. Channel catfish were dosed once with 10 mg/kg ABZ via stomach tube with manual restraint. Muscle tissue samples were collected at 8, 16, 24, 48, 72, 96 and 120 h postdose. A high-performance liquid chromatographic method was used to assay ABZ and its major metabolites: ABZ sulfoxide (ABZ-SO), ABZ sulfone (ABZ-SO2) and ABZ aminosulfone (ABZ-2-NH2SO2) in the muscle tissue. The results indicate that ABZ and ABZ-SO were present in low concentrations, i.e. <15 and <10 microg/kg, respectively, at 8 h postdose in catfish muscle with and without skin. ABZ-SO2 was present at 1 microg/kg concentration levels until 48 h in muscle alone and 72 h in muscle with skin. ABZ-2-NH2SO2 was not detected at any withdrawal periods.
authors.affiliation: Food and Drug Administration, CVM/Office of Research, Laurel, MD 20708, USA. badaruddin.shaikh@fda.hhs.gov
authors.forename: B
authors.initials: B
authors.lastname: Shaikh
authors.forename: N
authors.initials: N
authors.lastname: Rummel
authors.forename: C
authors.initials: C
authors.lastname: Gieseker
authors.forename: R
authors.initials: R
authors.lastname: Reimschuessel
mesh_terms: D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D005399:Fishes / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*
chemical_list: D000871:Anthelmintics; D015766:Albendazole