title: Feasibility of white-light time-resolved optical mammography.
abstract: We demonstrate the feasibility of white-light time-resolved optical mammography. The instrumentation is based on supercontinuum light generated in photonic crystal fiber and 32-channel parallel time-correlated single-photon-counting detection. Total measurement time is of the order of 10 min for typical clinical applications. Preliminary measurements performed on volunteers show the ability of the system to determine tissue constituent concentrations and structure over the entire breast area. Furthermore, measurements on a tissue-like sample demonstrate detection and characterization of inclusions.
authors.affiliation: ULTRAS-CNR-INFM and CNR-IFN, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. andrea.bassi@fisi.polimi.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Bassi
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Spinelli
authors.forename: Cosimo
authors.initials: C
authors.lastname: D'Andrea
authors.forename: Arianna
authors.initials: A
authors.lastname: Giusto
authors.forename: Johannes
authors.initials: J
authors.lastname: Swartling
authors.forename: Antonio
authors.initials: A
authors.lastname: Pifferi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Torricelli
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Cubeddu
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D007834:Lasers; D008327:Mammography / Q000295:instrumentation / Q000379:methods; D008875:Middle Aged; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*