title: Three-cycle fentanyl patch system significantly improves pain control in gynecologic cancer.
abstract: Pain affects many cancer patients, and in advanced stages of the disease it can significantly affect the quality of their lives. Morphine has long been the 'gold standard' for the treatment of cancer pain. However, its side-effects, particularly sedation and cognitive impairment at high doses, have encouraged the use of 'opioid rotation'. The transdermal fentanyl patch has advantages over oral morphine, with reduced side-effects and increased convenience in practical usage. The side-effects were reduced in patients who changed to the fentanyl patch, but rescue analgesia was often needed because of the decrease of fentanyl release from the patch, especially on the patch replacement day. We have developed a three-cycle fentanyl patch system that provided an appropriate pain control, and this system should be considered for pain relief in cancer patients.
authors.affiliation: Department of Obstetrics and Gynecology, Kansai Medical University, Moriguchi, Osaka, Japan. goldwoodchiharu@yahoo.co.jp
authors.forename: Chiharu
authors.initials: C
authors.lastname: Kanamori
authors.forename: Takanobu
authors.initials: T
authors.lastname: Kanamori
authors.forename: Michiharu
authors.initials: M
authors.lastname: Hayashi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Yorioka
authors.forename: Haruhide
authors.initials: H
authors.lastname: Kanzaki
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000150:complications; D000279:Administration, Cutaneous; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000494:pharmacology; D005833:Genital Neoplasms, Female / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000150:complications; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl