Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention.
Aberrant arachidonic acid metabolism has recently received intensive attention in the field of cancer research. Recent discoveries regarding the long-term cardiovascular side effects of cyclooxygenase 2 inhibitors have cast doubts on their use for cancer chemoprevention. Although such a problem does not undermine the importance of cyclooxygenase 2 as a cancer chemopreventive target, investigation into other AA-metabolizing pathways that are also important in inflammation and inflammation-associated carcinogenesis is necessary. Here, the important role of the 5-lipoxygenase pathway in carcinogenesis is reviewed. Inhibition of the 5-lipoxygenase pathways clearly has chemopreventive effects on various cancers, and hence further studies on its enzymes, metabolites and receptors for cancer chemoprevention and therapy are warranted.
Chen
Xiaoxin
X
Cancer Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA. lchen@nccu.edu
Sood
Sandeep
S
Yang
Chung S
CS
Li
Ning
N
Sun
Zheng
Z
D058927:5-Lipoxygenase-Activating Proteins; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001094:Arachidonate 5-Lipoxygenase / Q000502:physiology*; D016718:Arachidonic Acid / Q000378:metabolism*; D002352:Carrier Proteins / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007975:Leukotriene B4 / Q000502:physiology; D017997:Leukotriene C4 / Q000502:physiology; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins / Q000502:physiology; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology* / Q000517:prevention & control; D018077:Receptors, Leukotriene / Q000502:physiology; D018102:Receptors, Leukotriene B4 / Q000502:physiology
D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D016588:Anticarcinogenic Agents; D002352:Carrier Proteins; D004791:Enzyme Inhibitors; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D018077:Receptors, Leukotriene; D018102:Receptors, Leukotriene B4; D007975:Leukotriene B4; D016718:Arachidonic Acid; D017997:Leukotriene C4; D001094:Arachidonate 5-Lipoxygenase; C083169:leukotriene D4 receptor