Parallel synthesis of arrays of amino-acid-derived isocyanoamides useful as starting materials in IMCR.
Arrays of amino-acid-derived isocyanoamides are conveniently produced on a multigram scale in one step by the solventless aminolysis of the corresponding methyl esters with primary or secondary aliphatic amines. Most of the corresponding isocyanides precipitate during the reaction and can be filtered to yield highly pure, colorless, and odorless solids. They are potentially useful in the combinatorial chemistry of multicomponent reactions.
Dömling
Alexander
A
ABC-Pharma, Franckensteinstrasse 9a, 81243 München, Germany. Alex.doemling@abc-pharma.de
Beck
Barbara
B
Fuchs
Thilo
T
Yazbak
Ahmad
A
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000577:Amides; D000596:Amino Acids; D003486:Cyanides