title: A disposable lab-on-a-chip platform with embedded fluid actuators for active nanoliter liquid handling.
abstract: In this work we present the development of a disposable liquid handling lab-on-a-chip (LOC) platform with embedded actuators for applications in analytical chemistry. The proposed platform for nanoliter liquid handling is based on a thermally responsive silicone elastomer composite, consisting of PDMS and expandable microspheres. In our LOC platform, we integrate active dosing, transportation and merging of nanoliter liquid volumes. The disposable platform successfully demonstrates precise sample volume control with smart microfluidic manipulation and on-chip active microfluidic components. It is entirely fabricated from low-cost materials using wafer-level processing. Moreover, an enzymatic reaction and real-time detection was successfully conducted to exemplify its applicability as an LOC.
authors.affiliation: Microsystem Technology Lab, School of Electrical Engineering, Royal Institute of Technology, Stockholm, Sweden. bjorn.samel@ee.kth.se
authors.forename: Björn
authors.initials: B
authors.lastname: Samel
authors.forename: Volker
authors.initials: V
authors.lastname: Nock
authors.forename: Aman
authors.initials: A
authors.lastname: Russom
authors.forename: Patrick
authors.initials: P
authors.lastname: Griss
authors.forename: Göran
authors.initials: G
authors.lastname: Stemme
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods; D004209:Disposable Equipment; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008832:Microchemistry / Q000295:instrumentation* / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D012996:Solutions; D013048:Specimen Handling / Q000295:instrumentation* / Q000379:methods
chemical_list: D012996:Solutions