Interferon-alfa treatment of essential thrombocythemia during pregnancy.
We report on 2 successful pregnancies in a young woman who has essential thrombocythemia. The platelet count remained well controlled with interferon-alfa administration together with acetylsalicylic acid in each pregnancy. The present case and the published series suggest that close monitoring of the platelet count is crucial and that interferon may be the preferred therapeutic option in the management of pregnancy in patients with essential thrombocythemia.
Iwashita
Toshiko
T
Department of Obstetrics and Gynecology, Takeda General Hospital, Kyoto.
Fujitani
Mayumi
M
Yamamoto
Yoshiaki
Y
Katsurada
Tatsuya
T
Yoshida
Yataro
Y
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007231:Infant, Newborn; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D013920:Thrombocythemia, Essential / Q000188:drug therapy*; D013923:Thromboembolism / Q000517:prevention & control
D000925:Anticoagulants; D007155:Immunologic Factors; D016898:Interferon-alpha; D001241:Aspirin