title: Expression of viral microRNAs in Epstein-Barr virus-associated gastric carcinoma.
abstract: Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.
authors.affiliation: Research Institute of Immunobiology, Catholic University of Korea, Seoul, Korea.
authors.forename: Do Nyun
authors.initials: DN
authors.lastname: Kim
authors.forename: Hiun-Suk
authors.initials: HS
authors.lastname: Chae
authors.forename: Sang Taek
authors.initials: ST
authors.lastname: Oh
authors.forename: Jin-Hyoung
authors.initials: JH
authors.lastname: Kang
authors.forename: Cho Hyun
authors.initials: CH
authors.lastname: Park
authors.forename: Won Sang
authors.initials: WS
authors.lastname: Park
authors.forename: Kenzo
authors.initials: K
authors.lastname: Takada
authors.forename: Jae Myun
authors.initials: JM
authors.lastname: Lee
authors.forename: Won-Keun
authors.initials: WK
authors.lastname: Lee
authors.forename: Suk Kyeong
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005260:Female; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
chemical_list: C083278:BHRF1 protein, Human herpesvirus 4; D035683:MicroRNAs; D014764:Viral Proteins