title: Chromosomal imbalances in pediatric Burkitt-like lymphoma and review of the literature in relation to other germinal center derived B-cell tumors.
abstract: This study reports on the cytogenetic features of a novel case of pediatric Burkitt-like lymphoma (BLL), that adds to the three published. Four groups of cytogenetic abnormalities were detected in the present case: (1) imbalances shared by most germinal center (GC) derived B-cell tumors including BLL (+1q, -6q, -8p, +8q24 and +11); (2) imbalances already reported in adult but not in pediatric BLL cases and shared with most GC B-cell tumors (+7, -9p, -9q, +12q, -13q, +17, +19, -3 and -4); (3) imbalances already reported in pediatric but not in adult BLL cases and shared with some GC B-cell tumors (-2q); and (4) imbalances never described before in pediatric or adult BLL, but present in different GC B-cell tumors (-6p, -1p and -18q). In view of the paucity of pediatric BLL cases published, this report adds novel, relevant information on the molecular cytogenetic features of this rare tumor.
authors.affiliation: Laboratory of Oncology, Giannina Gaslini Institute, Genoa, Italy. annalisapezzolo@ospedale-gaslini.ge.it
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pezzolo
authors.forename: Roberta
authors.initials: R
authors.lastname: Cinti
authors.forename: Francesca
authors.initials: F
authors.lastname: Negri
authors.forename: Federica
authors.initials: F
authors.lastname: Parodi
authors.forename: Alberto
authors.initials: A
authors.lastname: Garaventa
authors.forename: Claudio
authors.initials: C
authors.lastname: Gambini
authors.forename: Vito
authors.initials: V
authors.lastname: Pistoia
mesh_terms: D002051:Burkitt Lymphoma / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D002648:Child; D002877:Chromosomes, Human / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009693:Nucleic Acid Hybridization; D012196:Review Literature as Topic