title: Developing a tool for noninvasive monitoring of renal allografts.
abstract: Renal transplantation has emerged as the therapy of choice for many patients with end-stage renal disease. One of the major goals is to tailor immunosuppressive therapy to the individual needs of every patient at every time point post transplant, balancing the risk for rejection and over-immunosuppression. Such individualized treatment will require assays that can detect harmful processes in the allograft early and that can be measured repeatedly. In this review, advantages and disadvantages of current assays to monitor renal allografts noninvasively and how proteomic technology might contribute to the development of novel biomarkers to improve patient management will be discussed.
authors.affiliation: University Hospital Basel, Department for Transplantation Immunology and Nephrology, Petersgraben 4, 4031 Basel, Switzerland. schaubs@uhbs.ch
authors.forename: Stefan
authors.initials: S
authors.lastname: Schaub
authors.forename: John A
authors.initials: JA
authors.lastname: Wilkins
authors.forename: David
authors.initials: D
authors.lastname: Rush
authors.forename: Peter
authors.initials: P
authors.lastname: Nickerson
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000379:methods* / Q000592:standards; D040901:Proteomics / Q000379:methods; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers; D007166:Immunosuppressive Agents