title: Function of an N-heterocyclic carbene ligand based on concept of chiral mimetic.
abstract: Function of a new N-heterocyclic carbene ligand based on the concept of a chiral mimetic is described. With (4R,5R)-4,5-diphenyl-1,3-dialkyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborates as N-heterocyclic carbene precursors, Rh-catalyzed enantioselective arylation (up to 27% ee) of aromatic aldehydes with arylboronic acids and Pd-catalyzed enantioselective intramolecular alpha-arylation (up to 66% ee) of N-(2-bromoaryl)-N-alkyl-2-arylpropanamides are investigated.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Arao
authors.forename: Kei
authors.initials: K
authors.lastname: Sato
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kondo
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Aoyama
mesh_terms: D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006838:Hydrocarbons / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D018716:Molecular Mimicry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D006838:Hydrocarbons; D008024:Ligands; C030011:carbene; D008697:Methane