title: [Mitochondrial ion channels].
abstract: Ion channels are proteins, which facilitate the ions flow throught biological membranes. In recent years the structure as well as the function of the plasma membrane ion channels have been well investigated. The knowledge of intracellular ion channels however is still poor. Up till now, the calcium channel described in endoplasmatic reticulum and mitochondrial porine are the examples of intracellular ion channels, which have been well characterized. The mitochondrial potassium channels: regulated by ATP (mitoK(ATP)) and of big conductance activated by Ca2+ (mitoBK(Ca)), which were described in inner mitochondrial membrane, play a key role in the protection of heart muscle against ischemia. In this review the last date concerning the mitochondrial ion channels as well as they function in cell metabolism have been presented.
authors.affiliation: Pracownia Wewnatrzkomórkowych Kanałów Jonowych, Instytut Biologii Doświadczalnej PAN im. Marcelego Nenckiego, Warszawa.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Skalska
authors.forename: Grazyna
authors.initials: G
authors.lastname: Debska-Vielhaber
authors.forename: Marta
authors.initials: M
authors.lastname: Głab
authors.forename: Bogusz
authors.initials: B
authors.lastname: Kulawiak
authors.forename: Dominika
authors.initials: D
authors.lastname: Malińska
authors.forename: Izabela
authors.initials: I
authors.lastname: Koszela-Piotrowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Bednarczyk
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Dołowy
authors.forename: Adam
authors.initials: A
authors.lastname: Szewczyk
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology; D018118:Chloride Channels / Q000378:metabolism; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000378:metabolism*; D008564:Membrane Potentials / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D051336:Mitochondrial Membranes / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism; D015222:Sodium Channels / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D018118:Chloride Channels; D007473:Ion Channels; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D024642:Potassium Channels, Voltage-Gated; D015222:Sodium Channels; D000255:Adenosine Triphosphate