Parkinsonism in type I Gaucher's disease.
The majority of patients with type I Gaucher's disease never develop neurological signs or symptoms. However, several case reports of Parkinson's disease associated with type I Gaucher's disease have been published, suggesting a genetic link between the two diseases. Hence, detailed clinical investigations are required when the two diseases occur simultaneously, in order to determine whether this is coincidental or whether a true association is present. We present a Japanese man in whom parkinsonism was associated with type I Gaucher's disease. Findings of brain positron tomography (PET) and metaiodobenzylguanidine (MIBG) cardiac scintigraphy are presented.
Itokawa
Kaori
K
Department of Neurology, Saitama Medical University.
Tamura
Naotoshi
N
Kawai
Nobutaka
N
Shimazu
Kunio
K
Ishii
Kenji
K
D019797:3-Iodobenzylguanidine; D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18; D005776:Gaucher Disease / Q000150:complications* / Q000235:genetics; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine