title: A ranklet-based image representation for mass classification in digital mammograms.
abstract: Regions of interest (ROIs) found on breast radiographic images are classified as either tumoral mass or normal tissue by means of a support vector machine classifier. Classification features are the coefficients resulting from the specific image representation used to encode each ROI. Pixel and wavelet image representations have already been discussed in one of our previous works. To investigate the possibility of improving classification performances, a novel nonparametric, orientation-selective, and multiresolution image representation is developed and evaluated, namely a ranklet image representation. A dataset consisting of 1000 ROIs representing biopsy-proven tumoral masses (either benign or malignant) and 5000 ROIs representing normal breast tissue is used. ROIs are extracted from the digital database for screening mammography collected by the University of South Florida. Classification performances are evaluated using the area Az under the receiver operating characteristic curve. By achieving Az values of 0.978 +/- 0.003 and 90% sensitivity with a false positive fraction value of 4.5%, experiments demonstrate classification results higher than those reached by the previous image representations. In particular, the improvement on the Az value over that achieved by the wavelet image representation is statistically relevant with the two-tailed p value <0.0001. Besides, owing to the tolerance that the ranklet image representation reveals to variations in the ROIs' gray-level intensity histogram, this approach discloses to be robust also when tested on radiographic images having gray-level intensity histogram remarkably different from that used for training.
authors.affiliation: Department of Physics, University of Bologna, Viale Berti-Pichat 6/2, 40127, Bologna, Italy. masotti@bo.infn.it
authors.forename: Matteo
authors.initials: M
authors.lastname: Masotti
mesh_terms: D000465:Algorithms; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D015233:Models, Statistical; D012372:ROC Curve; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D012680:Sensitivity and Specificity; D012984:Software