title: The neuropathology, medical management and dental implications of autism.
abstract: BACKGROUND
  A paucity of information exists in the dental literature about autism and its dental implications.
  
  
  METHODS
  The authors conducted a MEDLINE search for the period 2000 through 2006, using the term "autism," with the aim of defining the condition's clinical manifestations, dental and medical treatment and dental implications.
  
  
  RESULTS
  Autism is a severe developmental brain disorder that appears in infancy, persists throughout life, and is characterized by impaired social interaction, abnormalities in communication (both verbal and nonverbal) and restricted interests. Often accompanying the disorder are behavioral disturbances - such as self-mutilation, aggression, psychiatric symptoms and seizures - that necessitate the administration of multiple medications to help the affected person participate effectively in the educational and rehabilitative process.
  
  
  CONCLUSIONS
  Dentists caring for people with autism must be familiar with the manifestations of the disease and its associated features so that they can garner the maximum level of patient cooperation. They also must be familiar with the medications used to treat the associated features of the disorder because many of them cause untoward orofacial and systemic reactions and may precipitate adverse interactions with dental therapeutic agents.
authors.affiliation: VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA. arthur.friedlander@med.va.gov
authors.forename: Arthur H
authors.initials: AH
authors.lastname: Friedlander
authors.forename: John A
authors.initials: JA
authors.lastname: Yagiela
authors.forename: Victoria I
authors.initials: VI
authors.lastname: Paterno
authors.forename: Michael E
authors.initials: ME
authors.lastname: Mahler
mesh_terms: D001321:Autistic Disorder / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D002648:Child; D019140:Dental Care for Children / Q000379:methods; D003730:Dental Care for Persons with Disabilities / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans