Recombinant tissue plasminogen activator (r-TPA) in fibrin dissolution due to postoperative endophthalmitis.
BACKGROUND
The aim of this paper was to describe the use of r-TPA for fibrin clot dissolution following endophthalmitis.


METHODS
A 74-year-old man presented with painful loss of vision following routine uncomplicated cataract surgery.


METHODS
He underwent standard treatment for postoperative endophthalmitis but despite this, developed a dense fibrin clot. He underwent further intracameral injection of r-TPA.


RESULTS
Following the injection, he had complete clot dissolution within 2 hours without any complications.


CONCLUSIONS
R-TPA may be used effectively in the treatment of fibrin clots secondary to endophthalmitis following cataract surgery.
Riaz
Yasmin
Y
The Western Eye Hospital, Marylebone Road, London, UK.
Mehta
Jodhbir S
JS
Fernando
Arosho
A
Ferguson
Veronica
V
D000368:Aged; D002387:Cataract Extraction / Q000009:adverse effects*; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology; D005337:Fibrin / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011184:Postoperative Period; D011994:Recombinant Proteins / Q000627:therapeutic use*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D005337:Fibrin; D010959:Tissue Plasminogen Activator