title: Minimisation of palladium content in Suzuki cross-coupling reactions.
abstract: A protocol for conducting Suzuki reactions in a plate format amenable to use in library synthesis of biaryl compounds has been developed. A key objective was to determine reaction conditions which give biaryl products containing <10 ppm of Pd for a wide variety of building blocks. A Design of Experiments (DoE) approach for the identification of an optimised set of reaction conditions was successfully applied. The utility of the protocol developed has been demonstrated by preparation of an array of 96 biaryl compounds in a parallel fashion.
authors.affiliation: Evotec (UK) Ltd., 111 Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK. heather.tye@evotec.com
authors.forename: Heather
authors.initials: H
authors.lastname: Tye
authors.forename: Mark
authors.initials: M
authors.lastname: Whittaker
authors.forename: Shailesh
authors.initials: S
authors.lastname: Ramdeehul
mesh_terms: D002384:Catalysis; D002853:Chromatography, Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010165:Palladium / Q000737:chemistry*
chemical_list: D010165:Palladium