title: [Synergistic effects of human papillomavirus and phorbol ester in cell transformation.].
abstract: BACKGROUND
  To investigate the molecular mechanism of the synergistic effects of human papillomavirus (HPV) and phorbal esters (TPA) in cell transformation.
  
  
  METHODS
  The expression of oncogenes and anti-oncogenes in 293 cell line treated with HPV and TPA was studied by Southern Blot and RNA dot blot.
  
  
  RESULTS
  It was found that the synergistic effect induced the amplification of c-myc (4-8 times), increased expressing level of c-erbB-2 (32-64 times) and decreased expressing level of p16(1/4-1/8).
  
  
  CONCLUSIONS
  The above results show that the synergistic effect has an important role in development of carcinoma.
authors.affiliation: Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052, China.
authors.forename: S
authors.initials: S
authors.lastname: Cen
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: J J
authors.initials: JJ
authors.lastname: Xu
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Shen
authors.forename: Y
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D002460:Cell Line; D006801:Humans; D009857:Oncogenes; D027383:Papillomaviridae / Q000235:genetics; D010703:Phorbol Esters; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D010703:Phorbol Esters; D012333:RNA, Messenger