Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol.
Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly measured in schizophrenic patients. Patients with increased S100B levels showed elevated myo-inositol concentrations. This pilot study demonstrates a concomitant elevation of two markers indicating astrocyte activation in a subgroup of schizophrenic patients.
Rothermundt
Matthias
M
Department of Psychiatry, University of Muenster, Albert-Schweitzer-Str. 11, D-48301 Muenster, Germany. rothermu@uni-muenster.de
Ohrmann
Patricia
P
Abel
Simone
S
Siegmund
Ansgar
A
Pedersen
Anya
A
Ponath
Gerald
G
Suslow
Thomas
T
Peters
Marion
M
Kaestner
Florian
F
Heindel
Walter
W
Arolt
Volker
V
Pfleiderer
Bettina
B
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D009457:Neuroglia / Q000378:metabolism*; D011180:Postmortem Changes; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012559:Schizophrenia / Q000097:blood* / Q000473:pathology*
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D007294:Inositol