Neural crest inducing signals.
The formation of the neural crest has been traditionally considered a classic example of secondary induction, where signals form one tissue elicit a response in a competent responding tissue. Interactions of the neural plate with paraxial mesoderm or nonneural ectoderm can generate neural crest. Several signaling pathways converge at the border between neural and nonneural ectoderm where the neural crest will form. Among the molecules identified in this process are members of the BMP, Wnt, FGF and Notch signaling pathways. The concerted action of these signals and their downstream targets will define the identity of the neural crest.
Basch
Martín L
ML
House Ear Institute, Los Angeles, California, USA.
Bronner-Fraser
Marianne
M
D000818:Animals; D019521:Body Patterning; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D015509:Developmental Biology / Q000379:methods*; D004475:Ectoderm / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D009432:Neural Crest / Q000166:cytology*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D051880:Receptors, Notch; D051153:Wnt Proteins; D005346:Fibroblast Growth Factors