103Pd radioactive stent inhibits biliary duct restenosis and reduces smooth muscle actin expression during duct healing in dogs.
BACKGROUND
This study was designed to assess the expression of smooth muscle actin (SMA) in the healing process after implanting a (103)Pd radioactive stent in the biliary duct, and to discuss the function and significance of this stent in preventing biliary stricture formation.


METHODS
A model of biliary injury in dogs was made and then a (103)Pd radioactive stent was positioned in the biliary duct. The expression and distribution of SMA were assessed in the anastomotic tissue 30 days after implantation of the stent.


RESULTS
SMA expression was less in the (103)Pd stent group than in the ordinary stent group. The (103)Pd stent inhibited scar contracture and anastomotic stenosis.


CONCLUSIONS
The (103)Pd stent can reduce the expression of SMA in the healing process and inhibit scar contracture and anastomotic stenosis in the dog biliary duct.
He
Gui-Jin
GJ
Department of General Surgery, Second Affiliated Hospital, China Medical University, Shenyang 110004, China. 23318199@163.com
Gao
Qin-Yi
QY
Xu
Shu-He
SH
Gao
Hong
H
Jiang
Tao
T
Dai
Xian-Wei
XW
Ma
Kai
K
D000199:Actins / Q000378:metabolism*; D000818:Animals; D017734:Bile Ducts, Extrahepatic / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D003251:Constriction, Pathologic / Q000473:pathology / Q000517:prevention & control; D004285:Dogs; D008297:Male; D009130:Muscle, Smooth / Q000378:metabolism; D010165:Palladium; D011868:Radioisotopes; D015607:Stents
D000199:Actins; D011868:Radioisotopes; D010165:Palladium