title: Potential anti-allergic ent-kaurene diterpenes from the bark of Suregada multiflora.
abstract: Two ent-kaurene diterpenes, ent-16-kaurene-3beta,15beta,18-triol (1) and ent-3-oxo-16-kaurene-15beta,18-diol (2), were isolated from a dichloromethane extract of the bark of Suregada multiflora along with five known diterpenes:ent-16-kaurene-3beta,15beta-diol (3), abbeokutone (4), helioscopinolide A (5), helioscopinolide C (6) and helioscopinolide I (7). Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1-7 possessed appreciable anti-allergic activities in RBL-2H3 cells model with IC50 values ranging from 22.5 to 42.2 microM.
authors.affiliation: Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
authors.forename: Sarot
authors.initials: S
authors.lastname: Cheenpracha
authors.forename: Orapun
authors.initials: O
authors.lastname: Yodsaoue
authors.forename: Chatchanok
authors.initials: C
authors.lastname: Karalai
authors.forename: Chanita
authors.initials: C
authors.lastname: Ponglimanont
authors.forename: Sanan
authors.initials: S
authors.lastname: Subhadhirasakul
authors.forename: Supinya
authors.initials: S
authors.lastname: Tewtrakul
authors.forename: Akkharawit
authors.initials: A
authors.lastname: Kanjana-opas
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029843:Suregada / Q000737:chemistry*; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D045786:Diterpenes, Kaurane; D010936:Plant Extracts; D001619:beta-N-Acetylhexosaminidases