title: General and highly efficient synthesis of 2-alkylideneazetidines and beta-lactams via copper-catalyzed intramolecular N-vinylation.
abstract: [Structure: see text] N-Tosyl-3-halo-3-butenylamines underwent efficient Ullmann-type coupling with the catalysis of CuI/N,N'-dimethylethylenediamine to afford 2-alkylideneazetidines, which could be readily converted to the corresponding beta-lactams by oxidation with O3.
authors.affiliation: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, PRC.
authors.forename: Hongjian
authors.initials: H
authors.lastname: Lu
authors.forename: Chaozhong
authors.initials: C
authors.lastname: Li