[Approaches to assessing the human risk of mutagens].
The assessment of the human risk of mutagens is a constituent of the general assessment of the risk of environment-pollutant chemicals to the population's health. An algorithm of assessing the risk of mutagens is proposed. Stage 1 (hazard identification) is to provide an expert analytical characterization of the mutagenic potential of the chemicals polluting the study object. Stage 2 (hazard characterization) is to analyze the quantitative dependences of the effect of mutagens in gametes and somatic cells of man and mammals. Stage 3 (effect evaluation) is to characterize the sources of pollution and the doses of mutagens affecting the population. Stage 4 (risk characterization) is to calculate the risk of mutagens to the population and individuals.
Zhurkov
V S
VS
Sycheva
L P
LP
Revazova
Iu A
IuA
Novikova
S M
SM
D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects*; D018876:Environmental Illness / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D009153:Mutagens / Q000009:adverse effects*; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology
D009153:Mutagens