Recurrent non-immune fetal hydrops: A case report.
BACKGROUND
Recurrent non-immune fetal hydrops (NIH) has been reported in the literature but is a rare entity, with fewer than 6 reported cases so far. It has been postulated to be related to a recessive gene.


METHODS
We report a case of recurrent fetal hydrops in a multigravida with no medical history of note. She presented in her current pregnancy with a significant history of having 4 (out of 7) previous pregnancies affected by hydrops.


METHODS
All the affected pregnancies resulted in mid-trimester pregnancy termination (MTPT) following diagnosis in the second trimester. Previous investigations for hydrops did not yield any obvious cause.


RESULTS
Her most recent pregnancy was unaffected. We discuss the possible differential diagnoses and the likelihood of autosomal recessive metabolic diseases being the aetiological factor.


CONCLUSIONS
Rare causes of fetal hydrops need to be excluded in cases of recurrent non-immune hydrops with no obvious aetiology following routine investigations.
Goh
Shen L
SL
Division of General Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore. goh.shen.li@kkh.com.sg
Tan
June V K
JV
Kwek
Kenneth Y C
KY
Yeo
George S H
GS
D000029:Abortion, Legal; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012008:Recurrence; D013789:Thalassemia