title: Bone augmentation in rabbit calvariae: comparative study between Bio-Oss and a novel beta-TCP/DCPD granulate.
abstract: OBJECTIVE
  In the present in vivo study, we compare the bone regeneration capacity of a novel brushite cement synthesized in our laboratory (DTG) with Bio-Oss using rabbits as an animal model.
  
  
  METHODS
  The study was performed in a group of 14 adult New Zealand rabbits using the bone conduction model. Two titanium cylinders were fixed into perforated slits made on the parietal cortical bone of each rabbit. One cylinder was left empty (negative control) and the other was filled with either Bio-Oss or brushite set-cement granules (test cylinder). Four weeks after the intervention, the animals were sacrificed and biopsies were taken. The following parameters were analysed: bone tissue augmentation, bone mineral density and biomaterial resorption. The comparison of data between the different groups was performed using the Mann-Whitney test with a significance level of p<0.05.
  
  
  RESULTS
  The mean bone mineral density and augmented mineral tissue inside the test cylinders were similar but higher than those of negative controls. Material resorption and bone tissue augmentation were significantly higher in the defects treated with the brushite-based set cement (p<0.05).
  
  
  CONCLUSIONS
  Brushite cement granules were more resorbable and generated more bone tissue than Bio-Oss inside the titanium cylinders placed in the rabbit calvaria.
authors.affiliation: Departamento Química-Física II, Complutense University of Madrid (UCM), Madrid 28040, Spain. fdamimim@farm.ucm.es
authors.forename: Faleh Mariño
authors.initials: FM
authors.lastname: Tamimi
authors.forename: Jesús
authors.initials: J
authors.lastname: Torres
authors.forename: Isabel
authors.initials: I
authors.lastname: Tresguerres
authors.forename: Celia
authors.initials: C
authors.lastname: Clemente
authors.forename: Enrique
authors.initials: E
authors.lastname: López-Cabarcos
authors.forename: Luis Jerez
authors.initials: LJ
authors.lastname: Blanco
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D001843:Bone Cements / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D005260:Female; D008903:Minerals / Q000627:therapeutic use*; D023421:Models, Animal; D010012:Osteogenesis / Q000502:physiology; D010294:Parietal Bone / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D013997:Time Factors
chemical_list: C077540:Bio-Oss; D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D008903:Minerals; C485817:beta-tricalcium phosphate; C494366:calcium phosphate, dibasic, dihydrate