Synthesis of plakortone B and analogs.
[Structure: see text] Use of a palladium-mediated alkoxycarbonylation/lactonization process provides a variable route to analogs of the plakortones. Four different analogs, including natural plakortone B, have been synthesized via this route.
Semmelhack
M F
MF
Department of Chemistry, Frick Chemistry Laboratory, Princeton University, Princeton, New Jersey 08544, USA. mfshack@princeton.edu
Hooley
Richard J
RJ
Kraml
Christina M
CM
D000818:Animals; D002384:Catalysis; D007783:Lactones / Q000138:chemical synthesis* / Q000378:metabolism; D015394:Molecular Structure; D010165:Palladium; D011161:Porifera / Q000378:metabolism
D007783:Lactones; C517066:plakortone B; D010165:Palladium