Towards erythropoietin mimicking small molecules.
Small molecules potentially mimicking the hormone erythropoietin have been discovered by screening of a library of rationally designed multicomponent reaction molecules in a functional cell-based assay.
Dömling
Alexander
A
ABC-Pharma, Franckensteinstr.9a, 81243 München, Germany. asd30+@pitt.edu
Beck
Barbara
B
Baumbach
William
W
Larbig
Gregor
G
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004921:Erythropoietin / Q000737:chemistry*; D006801:Humans; D007377:Interleukin-3 / Q000502:physiology; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D017467:Receptors, Erythropoietin / Q000187:drug effects; D011994:Recombinant Proteins
D007377:Interleukin-3; D017467:Receptors, Erythropoietin; D011994:Recombinant Proteins; D004921:Erythropoietin