title: Effective use of multi-arterial infusion chemotherapy for advanced non-small cell lung cancer patients: four clinical specified cases.
abstract: Arterial infusion chemotherapy is considered to be a treatment option for lung cancer patients who are intolerant of systemic chemotherapy because of an increased risk of severe toxicity. However, a number of major studies regarding arterial infusion chemotherapy for lung cancer have reported disappointing results. We performed arterial infusion chemotherapy for four patients with advanced NSCLC who were unable to receive systemic chemotherapy or radiotherapy. After detecting the feeding arteries precisely by angiography, low-dose chemotherapeutic agents were administrated into the corresponding arteries. In each case, multiple feeding arteries including main feeding arteries other than the bronchial artery were detected and a partial response (PR) was obtained without severe toxicity in all. We consider that the present method is an effective treatment option for lung cancer patients who are restricted from undergoing standard systemic chemotherapy or radiotherapy.
authors.affiliation: Third Department of Internal Medicine, Medical Faculty, University of Fukui, 23 Shimoaizuki Matsuoka-cho, Fukui Prefecture 910-1193, Japan. mnakanishi@nifty.ne.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Umeda
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Demura
authors.forename: Shingo
authors.initials: S
authors.lastname: Ameshima
authors.forename: Yukio
authors.initials: Y
authors.lastname: Chiba
authors.forename: Isamu
authors.initials: I
authors.lastname: Miyamori
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishizaki
mesh_terms: D000368:Aged; D000792:Angiography; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077143:Docetaxel; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D043823:Taxoids / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D000093542:Gemcitabine
chemical_list: D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D004317:Doxorubicin; D002945:Cisplatin; D000093542:Gemcitabine