Synthesis of functional poly(1,4-ketone)s bearing bioactive moieties by Pd-catalyzed insertion polymerization.
The synthesis of novel alternating polyketones bearing pendent bioactive moieties is presented. These materials were prepared by palladium catalyzed coordination polymerization of carbon monoxide and alpha-olefins substituted with protected tyrosine or with dipeptide sequences such as tyrosine-glycine, tyrosine-alanine, and tyrosine-valine. Copolymerization experiments of CO with monomers containing vitamin E or testosterone were also successfully performed under mild reaction conditions. The dicationic Pd (II) bis(phoshine) complex [Pd(dppp)(NCCH(3))(2)](BF(4))(2) was used as catalyst precursor giving rise to macromolecules with well-defined structures.
Malinova
Violeta
V
Department of Inorganic Chemistry 2, Materials and Catalysis, University of Ulm, Albert Einstein Allee 11, D-89069 Ulm, Germany.
Rieger
Bernhard
B
D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D007659:Ketones; D011108:Polymers; D010165:Palladium