title: Topical combination therapy for cutaneous squamous cell carcinoma in situ with 5-fluorouracil cream and imiquimod cream in patients who have failed topical monotherapy.
abstract: Topical therapeutic options for cutaneous squamous cell carcinoma in situ include 5-fluorouracil cream and imiquimod cream. Such treatment may be preferable to surgical or destructive modalities in certain anatomic locations and in instances where patients are unwilling or poor surgical candidates. We present 4 such patients with cutaneous squamous cell carcinoma in situ involving a digit. Each patient failed treatment with imiquimod cream as monotherapy. In addition, two patients failed treatment with 5-fluorouracil cream as monotherapy. All 4 responded completely to 5-fluorouracil and imiquimod cream as combination therapy. In patients who have failed monotherapy with a topical agent for cutaneous squamous cell carcinoma in situ, combination treatment using both topical 5-fluorouracil cream and imiquimod cream may be considered as an alternative therapeutic strategy.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Ondo
authors.forename: Steven M
authors.initials: SM
authors.lastname: Mings
authors.forename: Regina M
authors.initials: RM
authors.lastname: Pestak
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Shanler
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D016207:Cytokines / Q000502:physiology; D004341:Drug Evaluation; D004357:Drug Synergism; D005385:Fingers; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011355:Prodrugs / Q000493:pharmacokinetics; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy*; D051199:Toll-Like Receptor 7 / Q000037:antagonists & inhibitors; D051200:Toll-Like Receptor 8 / Q000037:antagonists & inhibitors
chemical_list: D000634:Aminoquinolines; D000964:Antimetabolites, Antineoplastic; D016207:Cytokines; D009824:Ointments; D011355:Prodrugs; D051199:Toll-Like Receptor 7; D051200:Toll-Like Receptor 8; D000077271:Imiquimod; D005472:Fluorouracil