The role of cadherin/catenin complex in malignant melanoma.
In the present review article the role of cadherin/catenin complex in cases of malignant melanoma is discussed in some detail. Cadherins represent the most important superfamily of adhesion molecules with epithelial E-cadherin being the most studied. Its role in normal state as well as in cancer invasion and metastasis and some other pathologies is crucial. E-cadherin expression is altered in malignant melanomas and its downregulation or absence is associated with melanoma invasion and metastasis potential. A shift from E-cadherin expression to neural N-cadherin expression in melanocytes is also detected in malignant melanomas formation. In addition, a discussion regarding the role of placental P-cadherin and vascular endothelial VE-cadherin as well as the recently identified molecule of dysadherin, is attempted in brief.
Bonitsis
N
N
Department of Physiology, Clinical Unit, Ioannina University Medical School, Ioannina, Greece.
Batistatou
A
A
Karantima
S
S
Charalabopoulos
K
K
D015820:Cadherins / Q000032:analysis / Q000378:metabolism*; D051177:Catenins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D015820:Cadherins; D051177:Catenins