Preparation of recombinant proteins in milk to improve human and animal health.
Milk is a very abundant source of proteins for animal and human consumption. Milk composition can be modified using transgenesis, including exogenous gene addition and endogenous gene inactivation. The study of milk protein genes has provided researchers with regulatory regions capable of efficiently and specifically driving the expression of foreign genes in milk. The projects underway are aimed at modifying milk composition, improving its nutritional value, reducing mammary infections, providing consumers with antipathogen proteins and preparing purified recombinant proteins for pharmaceutical use. The present paper summarises the current progress in this field.
Soler
Eric
E
BioProtein Technologies 63, Domaine de Vilvert, 78350, Jouy-en-Josas, France.
Thépot
Dominique
D
Rival-Gervier
Sylvie
S
Jolivet
Geneviève
G
Houdebine
Louis-Marie
LM
D000818:Animals; D030801:Animals, Genetically Modified; D002417:Cattle; D005260:Female; D005786:Gene Expression Regulation; D005822:Genetic Vectors; D006801:Humans; D007774:Lactation / Q000235:genetics* / Q000378:metabolism*; D008892:Milk / Q000737:chemistry / Q000592:standards*; D008894:Milk Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D009753:Nutritive Value; D019076:Transgenes
D008894:Milk Proteins