Chalcone based aryloxypropanolamines as potential antihyperglycemic agents.
A series of chalcone based aryloxypropanolamines were synthesized and evaluated for their antihyperglycemic activity in SLM and STZ rat models. Most of the compounds exhibited moderate to good activity ranging from 6.5% to 31.1% in SLM and 8.3% to 22.6% in STZ models, respectively. The most potent compound 5 g exhibited glucose lowering of 26.7% in SLM and 22.6% in STZ models. A definite structure-activity relationship was observed while varying the nature as well as the position of the amine in ring B.
Shukla
Poonam
P
Central Drug Research Institute, Lucknow, India.
Singh
Amar Bahadur
AB
Srivastava
Arvind Kumar
AK
Pratap
Ram
R
D000818:Animals; D050150:Chalones / Q000737:chemistry* / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D022702:Receptors, Adrenergic, beta-3 / Q000187:drug effects; D013395:Sucrose / Q000494:pharmacology
D050150:Chalones; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D022702:Receptors, Adrenergic, beta-3; D013395:Sucrose