title: Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias.
abstract: Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.
authors.affiliation: Procter and Gamble Pharmaceuticals, The Mason Business Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA.
authors.forename: Chris M
authors.initials: CM
authors.lastname: Jackson
authors.forename: Benjamin
authors.initials: B
authors.lastname: Blass
authors.forename: Keith
authors.initials: K
authors.lastname: Coburn
authors.forename: Laurent
authors.initials: L
authors.lastname: Djandjighian
authors.forename: Gina
authors.initials: G
authors.lastname: Fadayel
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Fluxe
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Hodson
authors.forename: John M
authors.initials: JM
authors.lastname: Janusz
authors.forename: Michael
authors.initials: M
authors.lastname: Murawsky
authors.forename: James M
authors.initials: JM
authors.lastname: Ridgeway
authors.forename: Ronald E
authors.initials: RE
authors.lastname: White
authors.forename: Shengde
authors.initials: S
authors.lastname: Wu
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry* / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000188:drug therapy; D001282:Atrial Flutter / Q000188:drug therapy; D006801:Humans; D051666:Kv1.5 Potassium Channel / Q000037:antagonists & inhibitors*; D026902:Potassium Channel Blockers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000889:Anti-Arrhythmia Agents; C496981:KCNA5 protein, human; D051666:Kv1.5 Potassium Channel; D026902:Potassium Channel Blockers; D053778:Thiazolidines