title: Putative quantitative trait loci associated with the probability of contracting infectious bovine keratoconjunctivitis.
abstract: Infectious bovine keratoconjunctivitis, also known as pinkeye, is an economically important disease in cattle. The objective of this study was to detect QTL associated with infectious bovine keratoconjunctivitis in offspring from a Brahman x Hereford sire. The sire was mated to Hereford, Angus, and F1 cows to produce 288 offspring in 1994 and mated to MARC III ((1/4) Hereford, (1/4) Angus, (1/4) Red Poll, and (1/4) Pinzgauer) cows in 1996 to produce 259 offspring (547 animals total). Infectious bovine keratoconjunctivitis was diagnosed by physical examination in 36 animals of the family. Records included unilateral and bilateral frequency, but not severity. Records were binary: 0 for unaffected and 1 for affected cattle. A putative QTL for infectious bovine keratoconjunctivitis was identified on chromosome 1, with a maximum F-statistic (F = 10.15; P = 0.0015) at centimorgan 79 of the linkage group. The support interval spanned centimorgans 66 to 110. There was also evidence suggesting the presence of a QTL for infectious bovine keratoconjunctivitis on chromosome 20, with a maximum F-statistic (F = 10.35; P = 0.0014) at centimorgan 16 of the linkage group. The support interval ranged from centimorgan 2 to 35. This report provides the initial evidence of QTL for infectious bovine keratoconjunctivitis. Although a candidate gene was identified for one of the regions of interest, further studies are needed to identify the genetic basis of resistance to the disease.
authors.affiliation: US Meat Animal Research Center, USDA, ARS, Clay Center, NE 68933-0166, USA. casas@email.marc.usda.gov
authors.forename: E
authors.initials: E
authors.lastname: Casas
authors.forename: R T
authors.initials: RT
authors.lastname: Stone
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000235:genetics*; D002511:Cephalosporins / Q000627:therapeutic use; D003023:Cloxacillin / Q000627:therapeutic use; D005260:Female; D020022:Genetic Predisposition to Disease; D007637:Keratoconjunctivitis / Q000188:drug therapy / Q000235:genetics / Q000662:veterinary*; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use; D040641:Quantitative Trait Loci
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C053503:ceftiofur; D003023:Cloxacillin; D010118:Oxytetracycline