title: Brain catecholamine alterations and pathological features with aging in Parkinson disease model rat induced by Japanese encephalitis virus.
abstract: We analyzed two disease model groups with rats infected by Japanese encephalitis virus (JEV), a 90-day group and a 180-day group after JEV infection. The time measured by the modified pole test showed that motor activities in these two groups were slower than those of age-matched control groups. Striatal dopamine (DA) levels were significantly decreased in all JEV-infected rats. Norepinephrine concentration in brain regions in the 180-day group was significantly decreased in the medulla oblongata and hypothalamus as compared with the control and 90-day group. Tyrosine hydroxylase-positive neurons were significantly decreased in both JEV-infected rat groups. These results suggest that DA decrease and pathological changes in JEV-infected model rats persist for a long time, at least up to 180 days, and this model will be useful for the evaluation of new anti-parkinsonian agents.
authors.affiliation: Department of Pharmacology, Health Sciences University of Hokkaido, Ishikari-Tobetsu, 061-0293, Hokkaido, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hamaue
authors.forename: A
authors.initials: A
authors.lastname: Ogata
authors.forename: M
authors.initials: M
authors.lastname: Terado
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: S
authors.initials: S
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Tashiro
authors.forename: M
authors.initials: M
authors.lastname: Hirafuji
authors.forename: M
authors.initials: M
authors.lastname: Minami
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000375:Aging / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D018349:Encephalitis Viruses, Japanese; D004672:Encephalitis, Japanese / Q000378:metabolism* / Q000473:pathology*; D005684:Gait / Q000502:physiology; D007150:Immunohistochemistry; D008125:Locus Coeruleus / Q000378:metabolism; D009043:Motor Activity / Q000502:physiology; D017072:Neostriatum / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine