Clinicopathologic study of intraductal papillary-mucinous tumors and mucinous cystic tumors of the pancreas.
OBJECTIVE
We analyzed clinicopathologic and imaging findings of intraductal papillary-mucinous tumors (IPMTs) and mucinous cystic tumors (MCTs) of the pancreas to evaluate the difference between IPMTs and MCTs, and to identify the signs indicative of malignancy in IPMTs.


METHODS
Clinicopathological features of 20 patients with IPMT and six patients with MCT of the pancreas were studied.


RESULTS
The patients with IPMT comprised 16 males and four females with a mean age of 62.9 years. Eighty percent of IPMTs were located in the pancreatic head, and the mean tumor size was 38.6mm. Recurrence was observed in one patient, who died of IPM adenocarcinoma. In contrast, all patients with MCT were females, with a mean age of 53.0 years. None of the MCTs arose in the pancreatic head, and the mean tumor size was 42.7mm. One patient died of MC adenocarcinoma, but all of the others survived without recurrence. The difference in gender, location of the tumor, and connection to the pancreatic duct reached statistical significance between IPMTs and MCTs. A significant connection to the pancreatic duct and high level of serum carbohydrate antigen 19-9 (CA19-9) was observed in the adenocarcinoma and moderate dysplasia groups of IPMT.


CONCLUSIONS
The main duct type and an elevation of serum CA19-9 level suggested malignancy in IPMTs.
Tanaka
Moritsugu
M
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Japan.
Sawai
Hirozumi
H
Okada
Yiuji
Y
Yamamoto
Minoru
M
Funahashi
Hitoshi
H
Takeyama
Hiromitsu
H
Manabe
Tadao
T
D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D011379:Prognosis; D011859:Radiography
D014408:Biomarkers, Tumor