title: LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians.
abstract: Myocardial infarction (MI) is currently among the leading causes of death in the developed world. A functional SNP (rs7291467) in galectin-2 (LGALS2), a protein involved in the LTA cascade, has been associated with susceptibility to MI in the Japanese population. We explored for the first time the hypothesis that the same SNP could be associated with the risk of MI in the British population. We conducted a case-control association study on a cohort of 752 British MI patients and 705 population controls. Power calculations showed that our resource had 98% of power to detect a significant association at OR of 1.57, and 80% power to detect an association with an OR of 1.35 (recessive model). Despite this, we found no significant association of allele frequency with risk of MI. Stratification for age, gender and other cardiovascular risk factors also failed to reveal an association of this polymorphism with MI.
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK. mm158@le.ac.uk
authors.forename: Massimo
authors.initials: M
authors.lastname: Mangino
authors.forename: Peter
authors.initials: P
authors.lastname: Braund
authors.forename: Ravi
authors.initials: R
authors.lastname: Singh
authors.forename: Rick
authors.initials: R
authors.lastname: Steeds
authors.forename: John R
authors.initials: JR
authors.lastname: Thompson
authors.forename: Kevin
authors.initials: K
authors.lastname: Channer
authors.forename: Nilesh J
authors.initials: NJ
authors.lastname: Samani
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D037501:Galectin 2 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000208:ethnology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology; D044465:White People / Q000235:genetics*
chemical_list: D037501:Galectin 2; C511926:LGALS2 protein, human