Follicular localization of dendritic cells in a xanthomatous inflammatory tumor of lung associated with human herpes virus-8 infection.
A 17-year-old man was treated with chemotherapy and radiation for nodular sclerosing Hodgkin lymphoma that presented as a left chest wall mass. Ten years later, a left upper lobe lung tumor was identified. The tumor resection demonstrated a 1.3-cm yellow lung nodule composed of epithelioid and spindled lipid-laden CD68+ and Factor XIIIa+ macrophages. Distinct follicular structures with dendritic cells positive for CD1a, fascin, and ALK-1 and largely devoid of intracytoplasmic lipid were a distinguishing feature of the lesion. Most of the xanthomatous macrophages expressed human herpes virus-8 antigen. The current World Health Organization classification of "inflammatory myofibroblastic tumors" is examined, and the association of a subset of "inflammatory pseudotumors" with immunodeficiency states and opportunistic infection is discussed.
Farris
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AB
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
Kradin
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RL
D030301:Activin Receptors, Type II / Q000032:analysis; D000293:Adolescent; D018949:Antigens, CD1 / Q000032:analysis; D020566:Dendritic Cells, Follicular / Q000473:pathology*; D006104:Granuloma, Plasma Cell / Q000473:pathology* / Q000821:virology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000821:virology; D008297:Male; D014973:Xanthomatosis / Q000473:pathology* / Q000821:virology
D018949:Antigens, CD1; C419393:CD1a antigen; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II