title: Anti-arthritic activity of a biopolymeric fraction from Euphorbia tirucalli.
abstract: The present study was undertaken to investigate the anti-arthritic activity of a biopolymeric fraction (BET) from plant Euphorbia tirucalli Boiss (Euphorbiaceae). The fraction showed dose dependent anti-arthritic activity and also showed in vivo immunomodulatory capacity being a major component in inhibiting arthritis. It caused suppression of CD4(+) and CD8(+) T cells, inhibition of intracellular Interleukin-2 (IL-2) and Interferon-gamma (IFN-gamma) by flowcytometry. It inhibited vascular permeability and the migration of leucocytes at the site of the insult. The oral LD(0) in both rats and mice was more than 2000 mg/kg.
authors.affiliation: Department of Pharmacology, Regional Research Laboratory, Canal Road, Jammu Tawi 180 001, J&K State, India. sarangbani@rediffmail.com
authors.forename: Sarang
authors.initials: S
authors.lastname: Bani
authors.forename: Anpurna
authors.initials: A
authors.lastname: Kaul
authors.forename: Beenish
authors.initials: B
authors.lastname: Khan
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Gupta
authors.forename: Naresh Kumar
authors.initials: NK
authors.lastname: Satti
authors.forename: Krishan Avtar
authors.initials: KA
authors.lastname: Suri
authors.forename: Ghulam Nabi
authors.initials: GN
authors.lastname: Qazi
mesh_terms: D000890:Anti-Infective Agents
chemical_list: D000890:Anti-Infective Agents