title: Validation of a new endoscopic technique to assess acid output in Zollinger-Ellison syndrome.
abstract: OBJECTIVE
  To safely manage the hypersecretory state in patients with Zollinger-Ellison syndrome, both upper endoscopy and gastric analysis are required to titrate optimal medical therapy. Conventional gastric analysis requires more than 1 hour to perform and results in significant patient dissatisfaction. In this study, we have validated endoscopic gastric analysis as a novel technique that can effectively replace conventional gastric analysis.
  
  
  METHODS
  In a prospective, cross-over study, 12 patients with Zollinger-Ellison syndrome underwent gastric analysis, first by the conventional method and then by an endoscopic technique performed on the same day. Acid concentration was determined by titration, volume output was recorded, and acid output was calculated using standard methodologies and formulas. Agreement was assessed following the Bland-Altman method. To assess repeatability, both techniques were repeated on the same day in a subset of patients.
  
  
  RESULTS
  Excellent agreement was reported between acid output (95% limits of agreement, -1.27 to 1.61 mEq/h) and acid concentration (95% limits of agreement, -0.01 to 0.01 mEq/mL), although poor agreement was observed between volume output measured. Endoscopic gastric analysis showed greater reproducibility regarding acid and volume output measured.
  
  
  CONCLUSIONS
  We introduce a new, rapid, reproducible, and accurate endoscopic technique to measure acid output in patients with Zollinger-Ellison syndrome who require both annual endoscopy and gastric analysis. The data presented here suggest that endoscopic gastric analysis would be equally effective in determining acid output in other hypersecretory states. Additional analysis of cost effectiveness is needed to evaluate its use as a screening tool in select populations.
authors.affiliation: Department of Gastroenterology and Hepatology, Veterans Administration Greater Los Angeles Healthcare System, and Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90073, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Oh
authors.forename: Hank S
authors.initials: HS
authors.lastname: Wang
authors.forename: Gordon V
authors.initials: GV
authors.lastname: Ohning
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Pisegna
mesh_terms: D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*