title: Stereocontrolled coupling between aldehydes and conjugated alkenals mediated by TiIII/H2O.
abstract: In the presence of water, titanocene(III) complexes promote a stereoselective C-C bond-forming reaction that provides gamma-lactols by radical coupling between aldehydes and conjugated alkenals. The method is useful for both intermolecular reactions and cyclizations. The relative stereochemistry of the products can be predicted with confidence with the aid of model Ti-coordinated intermediates. The procedure can be carried out enantioselectively using chiral titanocene catalysts. [reaction: see text].
authors.affiliation: Department of Organic Chemistry, Faculty of Sciences, University of Granada, E-18071 Granada, Spain.
authors.forename: Rosa E
authors.initials: RE
authors.lastname: Estévez
authors.forename: Juan L
authors.initials: JL
authors.lastname: Oller-López
authors.forename: Rafael
authors.initials: R
authors.lastname: Robles
authors.forename: Concepción R
authors.initials: CR
authors.lastname: Melgarejo
authors.forename: Andreas
authors.initials: A
authors.lastname: Gansäuer
authors.forename: Juan M
authors.initials: JM
authors.lastname: Cuerva
authors.forename: J Enrique
authors.initials: JE
authors.lastname: Oltra