title: Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol.
abstract: Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly measured in schizophrenic patients. Patients with increased S100B levels showed elevated myo-inositol concentrations. This pilot study demonstrates a concomitant elevation of two markers indicating astrocyte activation in a subgroup of schizophrenic patients.
authors.affiliation: Department of Psychiatry, University of Muenster, Albert-Schweitzer-Str. 11, D-48301 Muenster, Germany. rothermu@uni-muenster.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Rothermundt
authors.forename: Patricia
authors.initials: P
authors.lastname: Ohrmann
authors.forename: Simone
authors.initials: S
authors.lastname: Abel
authors.forename: Ansgar
authors.initials: A
authors.lastname: Siegmund
authors.forename: Anya
authors.initials: A
authors.lastname: Pedersen
authors.forename: Gerald
authors.initials: G
authors.lastname: Ponath
authors.forename: Thomas
authors.initials: T
authors.lastname: Suslow
authors.forename: Marion
authors.initials: M
authors.lastname: Peters
authors.forename: Florian
authors.initials: F
authors.lastname: Kaestner
authors.forename: Walter
authors.initials: W
authors.lastname: Heindel
authors.forename: Volker
authors.initials: V
authors.lastname: Arolt
authors.forename: Bettina
authors.initials: B
authors.lastname: Pfleiderer
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D009457:Neuroglia / Q000378:metabolism*; D011180:Postmortem Changes; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012559:Schizophrenia / Q000097:blood* / Q000473:pathology*
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D007294:Inositol