title: [Immune response in vaccinated and non-vaccinated mice infected with tick-borne encephalitis virus].
abstract: The paper deals with an investigation of an immune response in BALB/c mice immunized with tick-borne encephalitis (TBE) vaccine and infected with TBE virus and in non-immunized mice. The parameters of specific humoral (IgG and IgM) and cellular (gamma-interferon (IFN) and cell proliferation) immunities and the activity of cytokines (necrosis tumor factor-alpha, interleukin (IL)-1beta, IL-2, IL-6, IL-10, and IL-12) were studied. There were significant differences in the specific and nonspecific immune response of immunized and non-immunized animals. Noteworthy is the difference in the time course of changes in the levels of IL-6, IL-2, IL-12, and gamma-IFN in the immunized and non-immunized animals.
authors.forename: G M
authors.initials: GM
authors.lastname: Ignat'ev
authors.forename: E K
authors.initials: EK
authors.lastname: Bukin
authors.forename: E V
authors.initials: EV
authors.lastname: Otrashevskaia
authors.forename: M N
authors.initials: MN
authors.lastname: Rasshchepkina
authors.forename: M S
authors.initials: MS
authors.lastname: Vorob'eva
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002478:Cells, Cultured; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000276:immunology*; D007114:Immunization; D007115:Immunization Schedule; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007279:Injections, Subcutaneous; D007371:Interferon-gamma / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011933:Reagent Kits, Diagnostic; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D015850:Interleukin-6; D011933:Reagent Kits, Diagnostic; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D018664:Interleukin-12; D007371:Interferon-gamma