Brain cancer diagnosis and therapy with nanoplatforms.
Treatment of brain cancer remains a challenge despite recent improvements in surgery and multimodal adjuvant therapy. Drug therapies of brain cancer have been particularly inefficient, due to the blood-brain barrier and the non-specificity of the potentially toxic drugs. The nanoparticle has emerged as a potential vector for brain delivery, able to overcome the problems of current strategies. Moreover, multi-functionality can be engineered into a single nanoplatform so that it can provide tumor-specific detection, treatment, and follow-up monitoring. Such multitasking is not possible with conventional technologies. This review describes recent advances in nanoparticle-based detection and therapy of brain cancer. The advantages of nanoparticle-based delivery and the types of nanoparticle systems under investigation are described, as well as their applications.
Koo
Yong-Eun Lee
YE
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Reddy
G Ramachandra
GR
Bhojani
Mahaveer
M
Schneider
Randy
R
Philbert
Martin A
MA
Rehemtulla
Alnawaz
A
Ross
Brian D
BD
Kopelman
Raoul
R
D001812:Blood-Brain Barrier / Q000187:drug effects*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D053758:Nanoparticles / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000379:methods* / Q000639:trends