title: Impact of surgery on the development of duodenal cancer in patients with familial adenomatous polyposis.
abstract: OBJECTIVE
  Precancerous duodenal lesions in patients with familial adenomatous polyposis can be detected with duodenoscopy and treatment may prevent the development of cancer. We proposed to determine the frequency, natural history, cumulative risk, and risk factors of the precancerous duodenal lesions in a series of patients diagnosed in northern Italy.
  
  
  METHODS
  A prospective, endoscopic, follow-up protocol was performed in 50 patients examined by gastroduodenoscopy at two years of interval or less. The presence and severity of precancerous lesions of the duodenal mucosa were evaluated by Spigelman score. Twenty-five patients (50 percent) had proctocolectomy and ileoanal anastomosis, 15 (30 percent) had colectomy and ileorectal anastomosis, and 5 (10 percent) had proctocolectomy and definitive ileostomy from 0 to 3 years before the admission to the surveillance program. All patients showed more than a thousand adenomas in the colorectal mucosa. No patients with attenuated polyposis were found.
  
  
  RESULTS
  At the first endoscopy, duodenal adenomas could be detected in 19 of 50 patients (38 percent), whereas at the end of the follow-up, 43 (86 percent) had duodenal lesions. The final mean Spigelman score increased during the follow-up period (P<0.001 respect to baseline values). No duodenal cancer could be detected. Eleven patients had or developed severe precancerous duodenal lesions (Stage IV) treated with endoscopic or surgical resection. The distribution of patients with Stage IV according to the surgery of the colon was: 2 of 25 treated with ileoanal anastomosis and 8 of 15 with ileorectal anastomosis (P=0.0024, Fisher's exact test).
  
  
  CONCLUSIONS
  Patients with familial adenomatous polyposis are at risk of significant neoplasia. The natural history of precancerous lesions might be related to surgical treatment of colorectal neoplasms.
authors.affiliation: Institute of Haemathology and Medical Oncology L and A Seràgnoli, Via Massarenti 9, 40138, Bologna, Italy. gbiasco@med.unibo.it
authors.forename: G
authors.initials: G
authors.lastname: Biasco
authors.forename: E
authors.initials: E
authors.lastname: Nobili
authors.forename: C
authors.initials: C
authors.lastname: Calabrese
authors.forename: R
authors.initials: R
authors.lastname: Sassatelli
authors.forename: L
authors.initials: L
authors.lastname: Camellini
authors.forename: M A
authors.initials: MA
authors.lastname: Pantaleo
authors.forename: G
authors.initials: G
authors.lastname: Bertoni
authors.forename: A
authors.initials: A
authors.lastname: De Vivo
authors.forename: M
authors.initials: M
authors.lastname: Ponz De Leon
authors.forename: G
authors.initials: G
authors.lastname: Poggioli
authors.forename: G
authors.initials: G
authors.lastname: Bedogni
authors.forename: T
authors.initials: T
authors.lastname: Venesio
authors.forename: L
authors.initials: L
authors.lastname: Varesco
authors.forename: M
authors.initials: M
authors.lastname: Risio
authors.forename: G
authors.initials: G
authors.lastname: Di Febo
authors.forename: G
authors.initials: G
authors.lastname: Brandi
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000601:surgery; D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000601:surgery*; D000328:Adult; D001003:Anal Canal / Q000601:surgery; D000714:Anastomosis, Surgical; D004379:Duodenal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D004384:Duodenoscopy; D005260:Female; D005500:Follow-Up Studies; D018095:Germ-Line Mutation; D006801:Humans; D007082:Ileum / Q000601:surgery; D008297:Male; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000601:surgery; D016737:Proctocolectomy, Restorative; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery