title: Effect of steroids on increased permeability of blood vessels of the stria vascularis after auditory ossicle vibration by a drill in otologic surgery.
abstract: OBJECTIVE
  The vibration caused by drills used for middle ear surgery is considered one of the causes of postoperative sensorineural deafness. Seki et al reported that when drill-induced damage was created in the auditory ossicles of guinea pigs, permeability across the capillary vessels in the stria vascularis increased significantly with the duration of drill-induced vibration. The present study was undertaken to examine changes in permeability across the stria vascularis capillaries following vibration in experimental animals pretreated with steroids, with the goal of developing a method of preventing a vibration-induced increase in permeability across these capillaries.
  
  
  METHODS
  After an intravenous dose of hydrocortisone and horseradish peroxidase, the auditory ossicles of guinea pigs were vibrated with a drill for 60 seconds.
  
  
  RESULTS
  Intravenous steroid administration before vibration reduced the leakage of horseradish peroxidase from the stria vascularis capillaries after vibration.
  
  
  CONCLUSIONS
  The findings suggested that steroids suppress the increase in permeability across the stria vascularis capillaries that results from drill-induced vibration.
authors.affiliation: Department of Otorhinolaryngology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Morihiro
authors.initials: M
authors.lastname: Seki
authors.forename: Hiroe
authors.initials: H
authors.lastname: Miyasaka
authors.forename: Kensuke
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004432:Ear, Middle / Q000601:surgery*; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000517:prevention & control; D006735:Horseradish Peroxidase / Q000008:administration & dosage / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D013316:Stria Vascularis / Q000187:drug effects* / Q000648:ultrastructure; D013523:Surgical Equipment / Q000009:adverse effects*; D014732:Vibration / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D006735:Horseradish Peroxidase; D006854:Hydrocortisone