[The expression of pseudogene HMGA1L2 in thyroid lesions].
Pseudogene HMGA1L2 mRNA level was detected using RT-PCR in 50 cases of thyroid lesions. The results show that HMGA1L2 mRNA was found in all 12 cases of nodular goiter, all 9 cases of thyroid adenoma and all 15 cases of papillary carcinoma. In 14 cases of thyroid follicular carcinoma, However, the frequency of HMGA1L2 mRNA expression was 35.7%, which was significantly different from that in other types of thyroid lesions (P < 0.05). This is the first report of mRNA expression of pseudogene HMGA1L2 in nodular goiter and thyroid tumors. It indicate that pseudogene HMGA1L2 expression analysis could be helpful in differentiation between follicular carcinoma and adenoma.
Wang
Guo-Liang
GL
Department of Pathology, Shihezi University School of Medicine, Shihezi 832002, China. yuz1860@163.com
Zhang
Guo-Chang
GC
Li
Feng
F
Zhao
Jin
J
Hu
Wen-Hao
WH
Zhang
Jin-Fang
JF
Yin
Xiang-Li
XL
Guo
Chang-Jun
CJ
Jiang
Jin-Fang
JF
Liang
Wei-Hua
WH
D001483:Base Sequence; D003850:Deoxyribonuclease I / Q000378:metabolism; D006044:Goiter, Nodular / Q000235:genetics* / Q000473:pathology; D024003:HMGA Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011544:Pseudogenes / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
D024003:HMGA Proteins; D012333:RNA, Messenger; D003850:Deoxyribonuclease I