title: Lack of association of an insertion/deletion polymorphism in the G protein-coupled receptor 50 with bipolar disorder in a Northern Swedish population.
abstract: GPR50 is a G protein-coupled receptor, located on Xq28 and related to the melatonin receptor family. It is suggested as a functional and positional candidate gene for bipolar disorder (BP). Recently an insertion/deletion polymorphism in GPR50, Delta502-505, was found to be associated with BP in a Scottish association sample (P=0.007). When the analysis was restricted to female subjects, the association increased in significance (P=0.00023). We attempted to replicate this finding in a Northern Swedish association sample, but no significant association was detected (P=0.7, women only: P=0.65).
authors.forename: Maaike
authors.initials: M
authors.lastname: Alaerts
authors.forename: Tine
authors.initials: T
authors.lastname: Venken
authors.forename: An-Sofie
authors.initials: AS
authors.lastname: Lenaerts
authors.forename: Sonia
authors.initials: S
authors.lastname: De Zutter
authors.forename: Karl-Fredrik
authors.initials: KF
authors.lastname: Norrback
authors.forename: Rolf
authors.initials: R
authors.lastname: Adolfsson
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D013548:Sweden
chemical_list: C509754:GPR50 protein, human; D009419:Nerve Tissue Proteins; D043562:Receptors, G-Protein-Coupled