Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1.
The enantioselective total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C is reported. The approach involves tartrate-mediated, asymmetric nucleophilic epoxidation of a functionalized quinone monoketal to construct the highly substituted D-ring.
Lei
Xiaoguang
X
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, MA 02215, USA.
Porco
John A
JA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001391:Azo Compounds / Q000138:chemical synthesis*; D009285:Naphthoquinones / Q000138:chemical synthesis*; D000095602:Angucyclines and Angucyclinones
D000900:Anti-Bacterial Agents; D001391:Azo Compounds; D009285:Naphthoquinones; C515381:kinamycin C; D000095602:Angucyclines and Angucyclinones