Methods and protocols for prediction of immunogenic epitopes.
T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the identification of T-cell epitopes to specific MHC alleles. This article examines existing computational strategies for the study of peptide/MHC interactions. The most important bioinformatics tools and methods with relevance to the study of peptide/MHC interactions have been reviewed. We have also provided guidelines for predicting antigenic peptides based on the availability of existing experimental data.
Tong
Joo Chuan
JC
Institute of Infocomm Research, Singapore.
Tan
Tin Wee
TW
Ranganathan
Shoba
S
D000465:Algorithms; D000936:Antigen-Antibody Complex / Q000032:analysis / Q000276:immunology*; D001665:Binding Sites; D018604:Epitope Mapping / Q000379:methods*; D018984:Epitopes, T-Lymphocyte / Q000032:analysis / Q000737:chemistry / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis / Q000737:chemistry / Q000276:immunology*; D010455:Peptides / Q000032:analysis / Q000276:immunology*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*
D000936:Antigen-Antibody Complex; D018984:Epitopes, T-Lymphocyte; D006680:HLA Antigens; D010455:Peptides