title: Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis.
abstract: The IL-4 receptor (IL-4R) and IL-13 genes are candidate genes in atopic diseases. The IL-4Ralpha chain and IL-13 promoter polymorphisms are gain-of-function mutations associated with atopy. We tested whether polymorphisms in the IL-4Ralpha chain and the coding region of the IL-13 gene are associated with allergic rhinitis in a Korean population. Polymerase chain reaction-based assays for IL-4Ralpha Gln551Arg and IL-13 exon 4 G2044A were used for genotyping. There were no differences in the frequencies of the genotypes and alleles of IL-4Ralpha between the controls and patients. The frequency of the IL-13 exon 4 2044A allele was statistically different between the controls and patients. Our results suggest that the IL-13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans, whereas the IL-4Ralpha Gln551Arg polymorphism is not related to allergic rhinitis.
authors.affiliation: Department of Anatomy, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea.
authors.forename: Jeong Joong
authors.initials: JJ
authors.lastname: Kim
authors.forename: Jung Youl
authors.initials: JY
authors.lastname: Min
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005091:Exons / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics*; D007723:Korea; D008297:Male; D017354:Point Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D053660:Receptors, Interleukin-13 / Q000235:genetics*; D012221:Rhinitis, Allergic, Perennial / Q000208:ethnology / Q000235:genetics*
chemical_list: D017931:DNA Primers; D053662:Interleukin-4 Receptor alpha Subunit; D053660:Receptors, Interleukin-13