title: ADDP and PS-PPh3: an efficient Mitsunobu protocol for the preparation of pyridine ether PPAR agonists.
abstract: A series of pyridine ether PPAR agonists were synthesized through an ADDP and PS-PPh3 modified Mitsunobu protocol, which eliminated significant by-product formation. This method proved to be versatile, efficient and amenable to parallel synthesis.
authors.affiliation: Pfizer Global R&D, Department of Medicinal Chemistry, 10614 Science Center Drive, San Diego, CA 92121, USA. paul.humphries@pfizer.com
authors.forename: Paul S
authors.initials: PS
authors.lastname: Humphries
authors.forename: Quyen-Quyen T
authors.initials: QQ
authors.lastname: Do
authors.forename: David M
authors.initials: DM
authors.lastname: Wilhite