title: Overdependence on degraded gist memory in Alzheimer's disease.
abstract: Alzheimer's disease (AD) reduces associative effects on false recognition in the Deese-Roediger-McDermott task, either due to impaired memory for gist or impaired use of gist in memory decisions. Gist processes were manipulated by blocking or mixing studied words according to their associations and by varying the associative strength between studied and nonstudied words at test. Both associative blocking and associative strength had smaller effects on false recognition in AD patients than in control participants, consistent with gist memory impairments. However, unlike the case with control participants, blocking influenced true and false recognition equally in AD patients, demonstrating an overdependence on gist when making memory decisions. AD also impaired item-specific recollections, relative to control participants, as true recognition of studied words was reduced even when the two groups were equated on gist-based false recognition. We propose that the overdependence on degraded gist memory in AD is caused by even larger impairments in item-specific recollections.
authors.affiliation: Department of Psychology, University of Chicago, Chicago, IL 60637, USA. dgallo@uchicago.edu
authors.forename: David A
authors.initials: DA
authors.lastname: Gallo
authors.forename: Kameron R
authors.initials: KR
authors.lastname: Shahid
authors.forename: Meredith A
authors.initials: MA
authors.lastname: Olson
authors.forename: Todd M
authors.initials: TM
authors.lastname: Solomon
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Schacter
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Budson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D001245:Association Learning; D001288:Attention / Q000502:physiology; D003463:Cues; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D007802:Language; D008297:Male; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D009483:Neuropsychological Tests; D021641:Recognition, Psychology