title: [Nonerosive and erosive gastroesophageal reflux disease. Long-term results of laparoscopic anterior semifundoplication].
abstract: BACKGROUND
  The aim of this study was to evaluate long-term results of laparoscopic anterior semifundoplication in patients with nonerosive (NERD) and erosive (ERD) gastroesophageal reflux disease.
  
  
  METHODS
  The study includes the period from May 1997 to July 2005. Upper gastrointestinal endoscopy was performed in all 190 patients. The severity of reflux esophagitis was classified according to Savary and Miller (grades I-IV). A standardized questionnaire was used for follow-up, and the modified symptomatic DeMeester score was assessed.
  
  
  RESULTS
  58.5 years of age (range 27-80), patients with nonerosive reflux disease (n=83) were significantly older than those with erosive reflux disease (n=107) (48 years range 15-84) (p=0.0001). Patients with NERD had a lower modified symptomatic DeMeester score postoperatively of 0 (range 0-4) than patients with ERD, of 1 (range 0-5), though without statistical significance (p=0.151).
  
  
  CONCLUSIONS
  Laparoscopic anterior semifundoplication leads to comparable symptomatic long-term results in both NERD and ERD. Anterior semifundoplication is a good therapeutic option for selected patients with persistent reflux-associated symptoms and endoscopically negative esophagitis.
authors.affiliation: Klinik für Allgemein- und Abdominalchirurgie, Johannes-Gutenberg-Universität, Langenbeckstrasse 1, 55131 Mainz, Germany. gockel@ach.klinik.uni-mainz.de
authors.forename: I
authors.initials: I
authors.lastname: Gockel
authors.forename: A
authors.initials: A
authors.lastname: Heintz
authors.forename: M
authors.initials: M
authors.lastname: Domeyer
authors.forename: W
authors.initials: W
authors.lastname: Kneist
authors.forename: T T
authors.initials: TT
authors.lastname: Trinh
authors.forename: T
authors.initials: T
authors.lastname: Junginger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D016896:Treatment Outcome