title: Liver regeneration and hemodynamics in pigs with mesocaval shunt.
abstract: BACKGROUND
  A surgical technique using a mesocaval shunt and downstream ligation of the superior mesenteric vein has been recently proposed to overcome the size limitations that restrict the use of partial liver grafts. We designed an experimental study in pigs to evaluate the capacities of liver regeneration and hemodynamic changes after completion of this procedure.
  
  
  METHODS
  Liver regeneration after left hepatectomy was compared between two groups of five pigs, with or without mesocaval shunt, sacrificed 11 to 14 days after surgery. A third group of five animals was used for hemodynamic studies.
  
  
  RESULTS
  Liver regeneration in study animals was 45.3% of controls. This was obtained despite a reduction of the venous inflow to 15.6% of the control, resulting in a net decrease of the total blood inflow to 56% of the control, despite a compensatory increase in the arterial inflow. There was no significant difference in mitotic index, hepatocellular size, and glycogen content between study and control animals.
  
  
  CONCLUSIONS
  Our experimental study confirms that the regenerative capacities of the pig liver are largely preserved despite the dramatic reduction of the venous blood inflow, reduced to its gastroduodenosplenopancreatic component. This lends further support to the hypothesis that the gastroduodenosplenopancreatic blood is enriched in hepatotrophic factors, likely to originate from the pancreas and duodenum.
authors.affiliation: Faculté Laennec, Lyon, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Pouyet
authors.forename: Isabelle
authors.initials: I
authors.lastname: Méchet
authors.forename: Christian
authors.initials: C
authors.lastname: Paquet
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Scoazec
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D006003:Glycogen / Q000378:metabolism; D006498:Hepatectomy / Q000379:methods*; D008026:Ligation; D008099:Liver / Q000098:blood supply / Q000166:cytology / Q000601:surgery; D008102:Liver Circulation; D008115:Liver Regeneration; D016031:Liver Transplantation; D019520:Living Donors; D008642:Mesenteric Veins / Q000601:surgery*; D013152:Splanchnic Circulation; D034421:Sus scrofa; D014656:Vascular Surgical Procedures / Q000379:methods*; D014682:Vena Cava, Inferior / Q000601:surgery*
chemical_list: D006003:Glycogen