Paget's disease from Western India.
OBJECTIVE
To prospectively study prevalence of Paget's disease from Western India.


METHODS
Seventeen consecutive cases from Western India from 1998 to 2005 are analysed for the clinical, biochemical, skeletal profile. Seventeen cases (15 males & 2 females) with mean age of 62 were diagnosed


RESULTS
The Western Indian cohort of Paget's disease has male preponderance with a mean age of 62 years at onset. Its clinical features are pain, fracture and typical skeletal involvement. It is a non-familial, polyostotic disease with pelvis, skull, spine and femur being the commonly affected bone sites. Elevated alkaline phosphatase is typical which responds well to bisphosphonate therapy in 6 months. Most cases do well with low dose alendronate (10-20mg/day).


CONCLUSIONS
Paget's disease in western India is rare with classical clinical, radiological and biochemical features and responds well to low dose alendronate therapy. In eight years, seventeen cases of Paget's disease were seen from Western India indicating though still rare is present in this population of Western India.
Joshi
Shashank R
SR
Lilavati and Bhatia Hospital, Mumbai.
Ambhore
S
S
Butala
N
N
Patwardhan
M
M
Kulkarni
M
M
Pai
B
B
Karne
R
R
D000368:Aged; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D004704:Endocrinology; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy / Q000453:epidemiology*; D010044:Outpatient Clinics, Hospital / Q000706:statistics & numerical data; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D017678:Sex Distribution
D050071:Bone Density Conservation Agents; D004164:Diphosphonates