title: Immunogenetics of pemphigus: an update.
abstract: Pemphigus are rare but informative models of organ-specific autoimmune diseases, resulting from the interplay of environmental, genetic and stochastic factors. There are many arguments to consider that pemphigus have a genetic basis involving, as many other autoimmune diseases, several different genes with additive or synergistic effects. So far, the unique strategy used to identify the contributive loci has been direct analysis of candidate genes through conventional case-control association studies. The major histocompatibility complex in particular the class II locus was demonstrated to be associated with pemphigus with a high rate of replicability. The progresses in the understanding of pemphigus physiopathology and the development of new molecular tools offer new perspectives to unveiled the genetic basis of this group of autoimmune blistering diseases, as shown by recent studies of candidate genes expressed at different levels of the autoimmune process.
authors.affiliation: Faculté de Médicine et de Pharmacie, INSERM U519, Université de Rouen, Rouen, France.
authors.forename: François
authors.initials: F
authors.lastname: Tron
authors.forename: Danièle
authors.initials: D
authors.lastname: Gilbert
authors.forename: Pascal
authors.initials: P
authors.lastname: Joly
authors.forename: Hugo
authors.initials: H
authors.lastname: Mouquet
authors.forename: Laurent
authors.initials: L
authors.lastname: Drouot
authors.forename: Mourad Ben
authors.initials: MB
authors.lastname: Ayed
authors.forename: Myriam
authors.initials: M
authors.lastname: Sellami
authors.forename: Hatem
authors.initials: H
authors.lastname: Masmoudi
authors.forename: Sondès
authors.initials: S
authors.lastname: Makni
mesh_terms: D000818:Animals; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D020412:Multifactorial Inheritance / Q000235:genetics / Q000276:immunology; D010392:Pemphigus / Q000235:genetics* / Q000276:immunology*