Variation of the serotonin transporter gene SLC6A4 in the susceptibility to migraine with aura.
To replicate a reported association between migraine with aura (MA) and a promoter polymorphism in the serotonin transporter gene (SLC6A4), we performed a case-control study in a large German sample comprising 472 patients with MA and 506 controls. Neither this polymorphism nor a systematic analysis with single nucleotide polymorphisms capturing the main haplotype diversity of the SLC6A4 locus provided evidence for a contribution of SLC6A4 to the predisposition of complex inherited MA.
Todt
U
U
Institute of Human Genetics, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Freudenberg
J
J
Goebel
I
I
Heinze
A
A
Heinze-Kuhn
K
K
Rietschel
M
M
Göbel
H
H
Kubisch
C
C
D000328:Adult; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin