Bioadhesive controlled release systems of ornidazole for vaginal delivery.
Our objective was to develop a bioadhesive vaginal tablet formulation of ornidazole by using different polymer mixtures, to evaluate the bioadhesive tablet properties, and to investigate the irritation potential of the formulations to the rat vaginal tissue. Vaginal tablets of ornidazole were directly compressed with bioadhesive and swellable polymer mixtures as release-controlled agents. Carbopol 934 (Cp), pectin (Pc), hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose (Na CMC), and guar gum (GG) were used in different ratios. Bioadhesive properties, swelling capacity, release studies, and histological studies of the formulations were carried out. The bioadhesive strength between bovine vagina and surface of the tablets was determined by tensile experiments, and it was found to be dependent on Cp content. The release mechanism was described and found to be non-Fickian for all formulations. Dissolution data were evaluated statistically. No histological damage was found except one formulation containing high amount of guar gum.
Baloğlu
Esra
E
Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, Turkey. esra.baloglu@ege.edu.tr
Ozyazici
Mine
M
Yaprak Hizarcioğlu
Sinem
S
Senyiğit
Taner
T
Ozyurt
Doğan
D
Pekçetin
Cetin
C
D000268:Adhesiveness; D000282:Administration, Intravaginal; D000818:Animals; D001696:Biomechanical Phenomena; D002417:Cattle; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008962:Models, Theoretical; D009950:Ornidazole / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010599:Pharmacokinetics; D011108:Polymers / Q000493:pharmacokinetics / Q000627:therapeutic use; D051381:Rats; D012995:Solubility; D013607:Tablets; D017155:Wettability
D003692:Delayed-Action Preparations; D011108:Polymers; D013607:Tablets; D009950:Ornidazole