[Mechanism of diabetic macroangiopathy].
Diabetes is a strong risk factor for cardiovascular diseases. Hyperglycemia at post-prandial as well as fasting state explains a part of the risk. Several disorders induced by hyperglycemia such as activation of PKC, increased glycosylation and oxidative stress have been proposed as the underlying mechanisms. In addition to the hyperglycemia, several epidemiological studies have suggested that hyperinsulinemia or insulin-resistance is also associated with the cardiovascular diseases. Endothelial dysfunction and/or inflammation are postulated as key players in the hyperinsulinemic or insulin-resistant state. Recently, we found that insulin stimulates the proinflammatory gene expression in cultured vascular cells. In this article, I reviewed these hypothesis explaining how hyperglycemia or insulin-resistance caused macroangiopathy in diabetics.
Nishio
Yoshihiko
Y
Division of Endocrine and Metabolism, Department of Medicine, Shiga University of Medical Science.
D000818:Animals; D003324:Coronary Artery Disease / Q000209:etiology*; D003925:Diabetic Angiopathies / Q000209:etiology*; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D006946:Hyperinsulinism / Q000150:complications; D018836:Inflammation Mediators / Q000378:metabolism; D007333:Insulin Resistance; D018384:Oxidative Stress / Q000502:physiology; D019518:Postprandial Period; D011493:Protein Kinase C / Q000378:metabolism; D012307:Risk Factors
D017127:Glycation End Products, Advanced; D018836:Inflammation Mediators; D011493:Protein Kinase C