title: Comparison of rat mandible bone characteristics in F344 substrains, F344/Du and F344/N.
abstract: The characteristics of the mandible bone were compared through DXA methods between two major substrains of F344 rats, F344/DuCrlCrlj and F344/NSlc at around 60 days of age. Since these two substrains are clearly different in survival and mandible morphology, some genetic differences are supposed to exist. In contrast to a previous microsatellite analysis, clear and significant differences were detected in the body and mandible weights, the mandible bone mineral contents (BMC), bone area (AREA), bone mineral density (BMD) and bone mineral ratio (BMR), between F344/DuCrlCrlj and F344/NSlc, with the mandible molar teeth intact in the bone. Thus, care is needed in the experimental use of these substrains, as results may differ between them. The newly proposed parameter, BMR, may especially contribute to the comparison of bone characteristics among species.
authors.affiliation: Animal Facility for Aging Research (AFAR), National Institute for Longevity Sciences (NILS), Obu, Aichi, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Tanaka
authors.forename: Sachi
authors.initials: S
authors.lastname: Kuwahara
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Nishijima
authors.forename: Tamio
authors.initials: T
authors.lastname: Ohno
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagaya
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sumi
authors.forename: Osamu
authors.initials: O
authors.lastname: Miyaishi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Aoyama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Goto
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001835:Body Weight; D015519:Bone Density; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging* / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity