title: [Air pollution and cardiovascular and cerebrovascular disease. Pathophysiologic basis and groups at risk].
abstract: The pathophysiologic basis of the harmful action of air pollutants rests principally on their proinflammatory and prothrombotic effects. The principal pollutants currently identified as responsible for these effects are fine suspended particles (PM2.5) and ozone. Inflammatory effects, initially localized in the lungs, then become systemic. Analysis of groups at the highest risk of atherothrombotic events suggests the elderly may be most sensitive to the effects of air pollution.
authors.affiliation: Observatoire des infarctus de Côte-d'Or (RICO). Electronic address: marianne.zeller@u-bourgogne.fr.
authors.forename: Marianne
authors.initials: M
authors.lastname: Zeller
authors.affiliation: Registre dijonnais des accidents vasculaires cérébraux.
authors.forename: Maurice
authors.initials: M
authors.lastname: Giroud
authors.affiliation: Observatoire des infarctus de Côte-d'Or (RICO).
authors.forename: Clotilde
authors.initials: C
authors.lastname: Royer
authors.affiliation: Registre dijonnais des accidents vasculaires cérébraux.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Benatru
authors.affiliation: Climat et santé, Faculté de médecine, Dijon (21).
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Besancenot
authors.affiliation: Observatoire des infarctus de Côte-d'Or (RICO).
authors.forename: Luc
authors.initials: L
authors.lastname: Rochette
authors.affiliation: Observatoire des infarctus de Côte-d'Or (RICO).
authors.forename: Yves
authors.initials: Y
authors.lastname: Cottin
mesh_terms: D000367:Age Factors; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D000397:Air Pollution / Q000009:adverse effects* / Q000517:prevention & control; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000503:physiopathology; D003327:Coronary Disease / Q000150:complications; D048909:Diabetes Complications; D006801:Humans; D008168:Lung / Q000187:drug effects; D010083:Oxidants, Photochemical / Q000009:adverse effects; D010126:Ozone / Q000009:adverse effects; D052638:Particulate Matter / Q000009:adverse effects; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D010083:Oxidants, Photochemical; D052638:Particulate Matter; D010126:Ozone