Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis.
The H2O, H2O/MeOH (1:1) extracts from the wood of Taxus yunnanensis showed a remarkable inhibitory effect on induced histamine release from the human basophilic cell line, KU812. The eleven constituents purified from the wood extracts of Taxus yunnanensis were tested by an in vitro histamine release inhibition assay. Among them, secoisolarciresinol and taxiresinol were found to show inhibitory activities. A new neolignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol, was isolated from the wood of Taxus yunnanensis.
Koyama
Junko
J
Kobe Pharmaceutical University, Japan. j-koyama@kobepharma-u.ac.jp
Morita
Izumi
I
Kobayashi
Norihiro
N
Hirai
Keiichi
K
Simamura
Eriko
E
Nobukawa
Takahiro
T
Kadota
Shigetoshi
S
D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002072:Butylene Glycols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D002247:Carbon Isotopes; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D003903:Deuterium; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011409:Propylene Glycols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry*; D014934:Wood / Q000737:chemistry
C517195:2-(2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol; D018926:Anti-Allergic Agents; D002072:Butylene Glycols; D002247:Carbon Isotopes; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D010636:Phenols; D010936:Plant Extracts; D011409:Propylene Glycols; D043823:Taxoids; C483062:taxiresinol; D000001:Calcimycin; D003903:Deuterium; C060283:secoisolariciresinol