title: Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer.
abstract: We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P<0.001). Furthermore, median intra- and perinodal lymphatic endothelial cell proliferation fractions were higher in metastatically involved LNs (P<0.001). This is the first report demonstrating lymphangiogenesis in LN metastases of cancer in general and breast cancer in particular.
authors.affiliation: Translational Cancer Research Group Antwerp (Lab Pathology University Antwerp/University Hospital Antwerp, Edegem; Oncology Center, General Hospital St-Augustinus, Wilrijk), Antwerp, Belgium.
authors.forename: G G
authors.initials: GG
authors.lastname: Van den Eynden
authors.forename: I
authors.initials: I
authors.lastname: Van der Auwera
authors.forename: S J
authors.initials: SJ
authors.lastname: Van Laere
authors.forename: V
authors.initials: V
authors.lastname: Huygelen
authors.forename: C G
authors.initials: CG
authors.lastname: Colpaert
authors.forename: P
authors.initials: P
authors.lastname: van Dam
authors.forename: L Y
authors.initials: LY
authors.lastname: Dirix
authors.forename: P B
authors.initials: PB
authors.lastname: Vermeulen
authors.forename: E A
authors.initials: EA
authors.lastname: Van Marck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D015415:Biomarkers / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000556:secondary*; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000556:secondary; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D008562:Membrane Glycoproteins / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen; D000098853:Podoplanin
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D011960:Receptors, Estrogen; C117468:PDPN protein, human; D000098853:Podoplanin