title: Pregnancy loss rates after midtrimester amniocentesis.
abstract: OBJECTIVE
  The purpose of this study was to quantify the contemporary procedure-related loss rate after midtrimester amniocentesis using a database generated from patients who were recruited to the First And Second Trimester Evaluation of Risk for Aneuploidy trial.
  
  
  METHODS
  A total of 35,003 unselected patients from the general population with viable singleton pregnancies were enrolled in the First And Second Trimester Evaluation of Risk for Aneuploidy trial between 10 3/7 and 13 6/7 weeks gestation and followed up prospectively for complete pregnancy outcome information. Patients who either did (study group, n=3,096) or did not (control group, n=31,907) undergo midtrimester amniocentesis were identified from the database. The rate of fetal loss less than 24 weeks of gestation was compared between the two groups, and multiple logistic regression analysis was used to adjust for potential confounders.
  
  
  RESULTS
  The spontaneous fetal loss rate less than 24 weeks of gestation in the study group was 1.0% and was not statistically different from the background 0.94% rate seen in the control group (P=.74, 95% confidence interval -0.26%, 0.49%). The procedure-related loss rate after amniocentesis was 0.06% (1.0% minus the background rate of 0.94%). Women undergoing amniocentesis were 1.1 times more likely to have a spontaneous loss (95% confidence interval 0.7-1.5).
  
  
  CONCLUSIONS
  The procedure-related fetal loss rate after midtrimester amniocentesis performed on patients in a contemporary prospective clinical trial was 0.06%. There was no significant difference in loss rates between those undergoing amniocentesis and those not undergoing amniocentesis.
  
  
  METHODS
  II-2.
authors.affiliation: Mount Sinai School of Medicine, New York, New York, USA. keith.eddleman@mssm.edu
authors.forename: Keith A
authors.initials: KA
authors.lastname: Eddleman
authors.forename: Fergal D
authors.initials: FD
authors.lastname: Malone
authors.forename: Lisa
authors.initials: L
authors.lastname: Sullivan
authors.forename: Kim
authors.initials: K
authors.lastname: Dukes
authors.forename: Richard L
authors.initials: RL
authors.lastname: Berkowitz
authors.forename: Yara
authors.initials: Y
authors.lastname: Kharbutli
authors.forename: T Flint
authors.initials: TF
authors.lastname: Porter
authors.forename: David A
authors.initials: DA
authors.lastname: Luthy
authors.forename: Christine H
authors.initials: CH
authors.lastname: Comstock
authors.forename: George R
authors.initials: GR
authors.lastname: Saade
authors.forename: Susan
authors.initials: S
authors.lastname: Klugman
authors.forename: Lorraine
authors.initials: L
authors.lastname: Dugoff
authors.forename: Sabrina D
authors.initials: SD
authors.lastname: Craigo
authors.forename: Ilan E
authors.initials: IE
authors.lastname: Timor-Tritsch
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Carr
authors.forename: Honor M
authors.initials: HM
authors.lastname: Wolfe
authors.forename: Mary E
authors.initials: ME
authors.lastname: D'Alton
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D005313:Fetal Death / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second