title: Biochemical diagnosis and localization of pheochromocytoma: can we reach a consensus?
abstract: Pheochromocytomas can have a highly variable presentation, making diagnosis challenging. To think of the tumor represents the crucial initial step, but establishing the diagnosis requires biochemical evidence of excessive catecholamine production and imaging studies to localize the source. Currently, however, there exist no generally agreed upon guidelines based on which tests and testing algorithms should be used to confirm and locate or exclude a suspected pheochromocytoma. Choice of biochemical tests and imaging studies instead usually depends on institutional experience. At the First International Symposium on Pheochromocytoma (ISP2005), held in Bethesda in October 2005, a panel of experts and patient representatives discussed current problems and available options for tumor diagnosis and localization and formulated recommendations, which were subsequently agreed upon by those in attendance at the meeting. This article summarizes the discussion and recommendations derived from that session.
authors.affiliation: Department of Endocrinology, St. Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK, and Department of Medicine, University of Toronto, Ontario, Canada. a.b.grossman@qmul.ac.uk
authors.forename: Ashley
authors.initials: A
authors.lastname: Grossman
authors.forename: Karel
authors.initials: K
authors.lastname: Pacak
authors.forename: Anna
authors.initials: A
authors.lastname: Sawka
authors.forename: Jacques W M
authors.initials: JW
authors.lastname: Lenders
authors.forename: Debra
authors.initials: D
authors.lastname: Harlander
authors.forename: Robert T
authors.initials: RT
authors.lastname: Peaston
authors.forename: Rodney
authors.initials: R
authors.lastname: Reznek
authors.forename: James
authors.initials: J
authors.lastname: Sisson
authors.forename: Graeme
authors.initials: G
authors.lastname: Eisenhofer
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D000465:Algorithms; D006801:Humans; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000378:metabolism