title: Changes of hippocampal protein levels during postnatal brain development in the rat.
abstract: Information on postnatal brain protein expression is very limited, and we therefore compared hippocampal protein levels in rat hippocampus at different developmental time points using two-dimensional gel electrophoresis followed by mass spectrometrical protein identification and specific software for quantification. Proteins from several cascades as e.g., antioxidant, metabolic, cytoskeleton, proteasomal, and chaperone pathways were developmentally regulated, which is relevant for design and interpretation of protein chemical studies in the mammalian brain.
authors.affiliation: Medical University of Vienna, Department of Neonatology, Vienna, Austria.
authors.forename: Rachel
authors.initials: R
authors.lastname: Weitzdörfer
authors.forename: Harald
authors.initials: H
authors.lastname: Höger
authors.forename: Arnold
authors.initials: A
authors.lastname: Pollak
authors.forename: Gert
authors.initials: G
authors.lastname: Lubec
mesh_terms: D000375:Aging; D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005260:Female; D006624:Hippocampus / Q000254:growth & development*; D009419:Nerve Tissue Proteins / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
chemical_list: D009419:Nerve Tissue Proteins