title: C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients.
abstract: OBJECTIVE
  The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population.
  
  
  METHODS
  We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age-matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products.
  
  
  RESULTS
  The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over-represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (chi(2) = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2-3.4).
  
  
  CONCLUSIONS
  The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.
authors.affiliation: Psychiatry Service, Dual Diagnosis Unit, '12 de Octubre' University Hospital, Madrid, Spain. jhoenicka.hdoc@salud.madrid.org
authors.forename: J
authors.initials: J
authors.lastname: Hoenicka
authors.forename: M
authors.initials: M
authors.lastname: Aragüés
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez-Jiménez
authors.forename: G
authors.initials: G
authors.lastname: Ponce
authors.forename: I
authors.initials: I
authors.lastname: Martínez
authors.forename: G
authors.initials: G
authors.lastname: Rubio
authors.forename: M A
authors.initials: MA
authors.lastname: Jiménez-Arriero
authors.forename: T
authors.initials: T
authors.lastname: Palomo
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D013030:Spain
chemical_list: D017448:Receptors, Dopamine D2