Bone mineral density in hip-fracture patients with Parkinson's disease: a case-control study.
OBJECTIVE
To investigate bone mineral density (BMD) levels in patients with Parkinson's disease (PD) who sustained a hip fracture.


METHODS
Case-control study.


METHODS
Rehabilitation hospital in Italy.


METHODS
We investigated 831 out of 887 white patients consecutively admitted to a rehabilitation hospital because of an original hip fracture resulting from a fall. Twenty-eight (3.37%) of the 831 patients were affected by PD. Twenty-eight controls matched for sex, age, and hip-fracture type (cervical or trochanteric) were found among the 803 non-PD patients.


METHODS
Not applicable.


METHODS
BMD was assessed by dual-energy x-ray absorptiometry (DXA) at the unfractured femur. Five sites were investigated in each subject: total proximal femur, femoral neck, trochanter, intertrochanteric area, and Ward's triangle. DXA scan was performed a mean +/- standard deviation of 22.2 +/- 7.8 days after fracture occurrence in the 28 patients and 22.0 +/- 5.3 days after fracture occurrence in the 28 controls.


RESULTS
BMD expressed as a T score did not differ significantly between the 28 PD patients and the 28 controls, whereas z score in the PD patients was significantly lower than 0 +/- 1 in the age- and sex-matched general population at 4 of the 5 sites of BMD assessment.


CONCLUSIONS
A sample of PD fallers who sustained a hip fracture had femoral BMD levels similar to those found in matched hip-fracture fallers who did not suffer from PD and significantly lower than those found in the matched reference population.
Di Monaco
Marco
M
Osteoporosis Research Center, Presidio Sanitario San Camillo, Torino, Italy. Merdici@h-sancamillo.to.it
Vallero
Fulvia
F
Di Monaco
Roberto
R
Tappero
Rosa
R
Cavanna
Alberto
A
D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D006620:Hip Fractures / Q000145:classification / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*