Alzheimer's disease and type 2 diabetes mellitus: the cholinesterase connection?
Alzheimer's disease and type 2 diabetes mellitus tend to occur together. We sought to identify protein(s) common to both conditions that could suggest a possible unifying pathogenic role. Using human neuronal butyrylcholinesterase (AAH08396.1) as the reference protein we used BLAST Tool for protein to protein comparison in humans. We found three groups of sequences among a series of 12, with an E-value between 0-12, common to both Alzheimer's disease and diabetes: butyrylcholinesterase precursor K allele (NP_000046.1), acetylcholinesterase isoform E4-E6 precursor (NP_000656.1), and apoptosis-related acetylcholinesterase (1B41|A). Butyrylcholinesterase and acetylcholinesterase related proteins were found common to both Alzheimer's disease and diabetes; they may play an etiological role via influencing insulin resistance and lipid metabolism.
Sridhar
Gumpeny Ramachandra
GR
Endocrine and Diabetes Centre, 15-12-16 Krishnanagar, Visakhapatnam 530 002, India. sridharvizag@gmail.com
Thota
Hanuman
H
Allam
Appa Rao
AR
Suresh Babu
Changalasetty
C
Siva Prasad
Akula
A
Divakar
Ch
Ch
D000110:Acetylcholinesterase / Q000737:chemistry / Q000235:genetics*; D000544:Alzheimer Disease / Q000150:complications* / Q000201:enzymology; D017209:Apoptosis / Q000502:physiology; D002091:Butyrylcholinesterase / Q000737:chemistry / Q000235:genetics*; D019295:Computational Biology; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000209:etiology*; D004792:Enzyme Precursors / Q000235:genetics; D006801:Humans; D009474:Neurons / Q000201:enzymology; D016415:Sequence Alignment
D004792:Enzyme Precursors; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase