title: Effect of resveratrol on alcohol-induced mortality and liver lesions in mice.
abstract: BACKGROUND
  Resveratrol is a polyphenol with important antiinflammatory and antioxidant properties. We investigated the effect of resveratrol on alcohol-induced mortality and liver lesions in mice.
  
  
  METHODS
  Mice were randomly distributed into four groups (control, resveratrol-treated control, alcohol and resveratrol-treated alcohol). Chronic alcohol intoxication was induced by progressively administering alcohol in drinking water up to 40% v/v. The mice administered resveratrol received 10 mg/ml in drinking water. The animals had free access to standard diet. Blood levels were determined for transaminases, IL-1 and TNF-alpha. A histological evaluation was made of liver damage, and survival among the animals was recorded.
  
  
  RESULTS
  Transaminase concentration was significantly higher in the alcohol group than in the rest of the groups (p < 0.05). IL-1 levels were significantly reduced in the alcohol plus resveratrol group compared with the alcohol group (p < 0.05). TNF-alpha was not detected in any group. Histologically, the liver lesions were more severe in the alcohol group, though no significant differences between groups were observed. Mortality in the alcohol group was 78% in the seventh week, versus 22% in the alcohol plus resveratrol group (p < 0.001). All mice in the alcohol group died before the ninth week.
  
  
  CONCLUSIONS
  The results obtained suggest that resveratrol reduces mortality and liver damage in mice.
authors.affiliation: Department of Gastroenterology, Donostia Hospital, San Sebastián, Spain. castro@medynet.com
authors.forename: Luis
authors.initials: L
authors.lastname: Bujanda
authors.forename: María
authors.initials: M
authors.lastname: García-Barcina
authors.forename: Virginia
authors.initials: V
authors.lastname: Gutiérrez-de Juan
authors.forename: Joseba
authors.initials: J
authors.lastname: Bidaurrazaga
authors.forename: Marian Fernández
authors.initials: MF
authors.lastname: de Luco
authors.forename: Marian
authors.initials: M
authors.lastname: Gutiérrez-Stampa
authors.forename: Mikel
authors.initials: M
authors.lastname: Larzabal
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Hijona
authors.forename: Cristina
authors.initials: C
authors.lastname: Sarasqueta
authors.forename: Miguel
authors.initials: M
authors.lastname: Echenique-Elizondo
authors.forename: Juan I
authors.initials: JI
authors.lastname: Arenas
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000437:Alcoholism / Q000401:mortality* / Q000473:pathology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D004326:Drinking; D004435:Eating; D007375:Interleukin-1 / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000401:mortality* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D000637:Transaminases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D007375:Interleukin-1; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000077185:Resveratrol