Amino acid residues affecting drug pump function in Candida albicans--C. albicans drug pump function.
Membrane-located drug transporters are important components in the multidrug resistance of microbial cells and human tissues. In fungi, clinically important resistance to antifungal drugs most often results from the over-expression of efflux pump proteins in the plasma membrane of the resistant cell. This review describes studies of the ATP binding cassette (ABC) family of membrane efflux pumps in the opportunistic human pathogen Candida albicans and, in particular, examines how changes in the polypeptide sequence can affect pump function. The identification of amino acid residues affecting pump function can provide new insights into efflux pump mechanisms and the relationship between structure and function. Such information will be important for the design of pump inhibitors which could supplement existing antifungal drugs.
Holmes
Ann R
AR
Department of Oral Sciences, School of Dentistry, University of Otago, Dunedin, New Zealand.
Tsao
Sarah
S
Lamping
Erwin
E
Niimi
Kyoko
K
Monk
Brian C
BC
Tanabe
Koichi
K
Niimi
Masakazu
M
Cannon
Richard D
RD
D018528:ATP-Binding Cassette Transporters / Q000502:physiology; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000502:physiology*; D002176:Candida albicans / Q000235:genetics / Q000502:physiology*; D026141:Drug Resistance, Multiple, Fungal / Q000502:physiology*
D018528:ATP-Binding Cassette Transporters; D000596:Amino Acids