title: Anti-bacterial drug discovery using systems biology.
abstract: The pipeline for new antibacterials is bleak despite the fact that infectious diseases account for a quarter of all worldwide deaths due to disease. Bacteria are ideal organisms for a systems biology approach to understanding pathogenesis by combined use of genomic technologies and computer algorithms. This approach can be applied to identify control points in molecular networks, which could be targets for novel drugs.
authors.affiliation: Genesis Research and Development Corporation Limited, One Fox Street, Parnell, Auckland, New Zealand. a.kumble@genesis.co.nz
authors.forename: K D
authors.initials: KD
authors.lastname: Kumble
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy; D052117:Benzodioxoles / Q000737:chemistry / Q000627:therapeutic use; D015195:Drug Design; D016680:Genome, Bacterial / Q000235:genetics; D006801:Humans; D010880:Piperidines / Q000737:chemistry / Q000627:therapeutic use; D053284:Polyunsaturated Alkamides / Q000737:chemistry / Q000627:therapeutic use; D049490:Systems Biology
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; C008922:piperine