title: Protein NMR-based screening in drug discovery.
abstract: Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Maryland, Baltimore, 20 Penn Street, Baltimore, MD 21201, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Zartler
authors.forename: M J
authors.initials: MJ
authors.lastname: Shapiro
mesh_terms: D002626:Chemistry, Pharmaceutical; D007553:Isotope Labeling / Q000379:methods; D008024:Ligands; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009696:Nucleic Acids / Q000737:chemistry / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D009696:Nucleic Acids; D004364:Pharmaceutical Preparations; D011506:Proteins