title: Ambulatory blood pressure monitoring in obese children: role of insulin resistance.
abstract: OBJECTIVE
  To investigate the relationship between ambulatory blood pressure (ABPM) parameters and insulin resistance in obese children.
  
  
  METHODS
  A population of 56 obese prepubertal children was recruited for the study. They underwent ABPM, an oral glucose tolerance test and complete physical examination, including adiposity indexes such as body mass index (BMI), skinfolds, waist-to-hip ratio (WHR) and fat mass.
  
  
  RESULTS
  The standard deviation score for BMI was significantly correlated with 24-h systolic blood pressure (SBP) (r = 0.30; P = 0.02) and diastolic blood pressure (DBP) (r = 0.29; P = 0.03), daytime SBP and DBP (r = 0.28; P = 0.04 and r = 0.32; P = 0.02), night-time SBP and DBP (r = 0.32; P = 0.01 and r = 0.27; P = 0.04). Fat mass was correlated with 24-h SBP (r = 0.46; P = 0.005), daytime SBP (r = 0.40; P = 0.01) and night-time SBP (r = 0.49; P = 0.03). No correlations were found between ABPM parameters and WHR. Furthermore, significant correlations were found between insulin resistance indexes, such as the homeostasis model assessment of insulin resistance and quantitative insulin-sensitivity check index, and 24-h DBP (r = 0.34; P = 0.01 and r = -0.29; P = 0.03), daytime DBP (r = 0.35; P = 0.009 and r = -0.34; P = 0.01) and daytime SBP (r = 0.32; P = 0.02 and r = -0.27; P = 0.04). Only 24-h and daytime DBP remained correlated with insulin resistance after adjustment for obesity. The analysis of the circadian rhythm of blood pressure revealed that 24 out the 56 children were non-dippers.
  
  
  CONCLUSIONS
  The results of the present study indicate that adiposity and insulin resistance have an important role in influencing blood pressure in obese children, and also show a high prevalence of non-dipping phenomenon. This is of particular relevance because blood pressure tracks from childhood into adulthood and an already early-life high blood pressure is associated with an increased cardiovascular risk.
authors.affiliation: Department of Pediatrics, University of Chieti, Italy.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Marcovecchio
authors.forename: Luca
authors.initials: L
authors.lastname: Patricelli
authors.forename: Michele
authors.initials: M
authors.lastname: Zito
authors.forename: Rita
authors.initials: R
authors.lastname: Capanna
authors.forename: Mariapaola
authors.initials: M
authors.lastname: Ciampani
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiarelli
authors.forename: Angelika
authors.initials: A
authors.lastname: Mohn
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000503:physiopathology*