title: Design of endoperoxides with anti-Candida activity.
abstract: Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.
authors.affiliation: Department of Chemistry, The University of Adelaide, 5005 SA, Australia.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Avery
authors.forename: Peter I
authors.initials: PI
authors.lastname: Macreadie
authors.forename: Ben W
authors.initials: BW
authors.lastname: Greatrex
authors.forename: Tony V
authors.initials: TV
authors.lastname: Robinson
authors.forename: Dennis K
authors.initials: DK
authors.lastname: Taylor
authors.forename: Ian G
authors.initials: IG
authors.lastname: Macreadie
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016466:CHO Cells; D002176:Candida albicans / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D006224:Cricetinae; D015195:Drug Design; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D010545:Peroxides