Effects of fibroblast growth factors 19 and 20 on cell multiplication and locomotion in a human embryonal carcinoma cell line (Tera-2) in vitro.
BACKGROUND
The effects of two recently discovered heparin binding growth factors, FGF-19 and FGF-20, on the human embryonal carcinoma derived cell line Tera 2 were examined.


METHODS
Cell numbers, as well as cell migration were examined at the clonal level by light microscopy.


RESULTS
FGF-19, as well as FGF-20 promoted Tera 2 cell multiplication. Whereas FGF-20 promoted cell multiplication at low doses, FGF-19 was required at high doses to achieve a comparable effect. Moreover, FGF-19 did not significantly stimulate cell locomotion, while FGF-20 promoted cell motility at high doses.


CONCLUSIONS
FGF-19 and FGF-20 qualitatively exert different effects on cell survival and cell locomotion.
Engström
Wilhelm
W
Department of Biosciences and Veterinary Public Health, Swedish University of Agricultural Sciences, S-750 07 Uppsala, Sweden. wilhelm.engstrom@bvf.slu.se
Granerus
Marika
M
D018236:Carcinoma, Embryonal / Q000473:pathology*; D002465:Cell Movement; D049109:Cell Proliferation; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D011994:Recombinant Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C117476:FGF19 protein, human; C416003:FGF20 protein, human; D011994:Recombinant Proteins; D005346:Fibroblast Growth Factors