Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer.
Aromatase is a particularly good target in the treatment of estrogen receptor positive breast cancer. Novel carbon-11 labeled sulfonanilide analogues, N-[11C]methyl-N-(2-alkyloxy-4-nitrophenyl)-methanesulfonamides ([11C]3a-f, alkyl=propyl, isopropyl, 1-ethyl-propyl, cyclopentyl, cyclohexyl, and cyclohexylethyl), were designed and synthesized as potential PET agents for imaging of aromatase in breast cancer.
Wang
Min
M
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Lacy
Gabrielle
G
Gao
Mingzhang
M
Miller
Kathy D
KD
Sledge
George W
GW
Zheng
Qi-Huang
QH
D000328:Adult; D000813:Anilides / Q000138:chemical synthesis*; D047072:Aromatase Inhibitors / Q000138:chemical synthesis*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000201:enzymology*; D002250:Carbon Radioisotopes; D045744:Cell Line, Tumor; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D015195:Drug Design; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D007553:Isotope Labeling; D009578:Nitrobenzenes / Q000494:pharmacology; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013449:Sulfonamides / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles
D000813:Anilides; D047072:Aromatase Inhibitors; D002250:Carbon Radioisotopes; D052246:Cyclooxygenase 2 Inhibitors; D007202:Indicators and Reagents; D009578:Nitrobenzenes; D019275:Radiopharmaceuticals; D013449:Sulfonamides; D013778:Tetrazolium Salts; D013844:Thiazoles; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; C022616:thiazolyl blue