Cellular neurofibroma with atypia mimics sarcoma: report of a case with immunohistochemical staining pattern analysis and literature review.
A case of two sporadic cellular neurofibromas with atypia and one widespread hyalinization neurofibroma of the lumbar spine in a 51-year-old man without evidence of neurofibromatosis-1 is reported. Cellular neurofibroma with atypia is an unusual variant. The definite criteria for low-grade and high-grade malignant peripheral nerve sheath tumors as well as cellular neurofibroma are not well defined in the literature. The clinical significance of atypical cellular neurofibroma has rarely been systematically studied. To our knowledge, the concomitance of cellular architecture and cytologic atypia is rarely documented, and this is a rare report of atypical cellular neurofibroma. The recognition of this entity is of great importance to both pathologists and clinicians because atypical cellular neurofibroma is clever at masquerading both histologically and cytologically as a sarcoma; therefore, a precise diagnosis of this variant is essential because of the differences in treatment and clinical behavior between benignancy and malignancy. We also examined the immunohistochemical characteristics of CD34 positive cells and focal high expression of p53 up to 73% encountered in our case. To our knowledge, seldom have series or case reports elucidated this phenomenon.
Hu
Shih-Wen
SW
Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Hwang
Shiuh-Lin
SL
Lin
Wei-Chen
WC
Tsai
Kun-Bow
KB
D018952:Antigens, CD34 / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D009455:Neurofibroma / Q000737:chemistry / Q000473:pathology*; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology; D012509:Sarcoma / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000737:chemistry / Q000473:pathology*; D013194:Staining and Labeling; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D018952:Antigens, CD34; D016159:Tumor Suppressor Protein p53