title: Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis.
abstract: [Structure: see text] Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.
authors.affiliation: Department of Cosmetic Science, Chung Hwa College of Medical Technology, Tainan 717, Taiwan, Republic of China. wupl@mail.ncku.edu.tw
authors.forename: Pei-Lin
authors.initials: PL
authors.lastname: Wu
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Hsu
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
authors.forename: K F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002018:Bufanolides / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D031962:Kalanchoe / Q000737:chemistry*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D035261:Plant Components, Aerial / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C517069:12-oxohellebrigenin-3-O-4,6-dideoxyhexopyranoside; D000972:Antineoplastic Agents, Phytogenic; D002018:Bufanolides; D012503:Saponins; C517067:hellebrigenin-3-O-6'-deoxyglucopyranoside; C517068:hellebrigenin-3-O-fucopyranoside