title: Hepatitis B virus inhibiting constituents from Herpetospermum caudigerum.
abstract: From the ethanol extract of the seeds of Herpetospermum caudigerum wall, one new lignan compound 1, was isolated and characterized along with three known compounds 2, 3 and 4. The structure elucidation of the isolated new compound was performed on the basis of spectroscopic and chemical evidence. The structures of known compounds were determined by comparison of spectral data and physical data with those previously reported. The activity inhibiting hepatitis b virus was evaluated. Preliminary studies showed that compound 1 and 2 displayed promising inhibitory potential against hepatitis b virus.
authors.affiliation: 302 Hospital of PLA&PLA Institute of Chinese Materia Medica, Beijing, China. yhalpharm@126.com
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Yuan
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Xian-Yi
authors.initials: XY
authors.lastname: Li
authors.forename: Rong-Hui
authors.initials: RH
authors.lastname: You
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Huan
authors.initials: H
authors.lastname: Xie
authors.forename: Xiao-He
authors.initials: XH
authors.lastname: Xiao
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D019662:Cucurbitaceae / Q000737:chemistry*; D004247:DNA / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013045:Species Specificity; D013237:Stereoisomerism; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D008024:Ligands; D010936:Plant Extracts; D004247:DNA