title: Response and persistence of antibodies to PRP-T and DTwP vaccines with concomitant administration of conjugate vaccines.
abstract: We first studied the immunogenicity of PRP-T and DTwP vaccines in Filipino infants given at 6, 10 and 14 weeks concomitantly with either an aluminum adjuvanted eleven-valent pneumococcal conjugate vaccine (11PncTD) or a meningococcal diphtheria-conjugated vaccine as compared to a control group that received only DTwP/PRP-T. The GMCs and proportions of infants achieving protective antibody concentrations to DTwP and PRP-T vaccine antigens were similar among the groups. In the second phase, the control group received 11PncTD at 18 weeks and the antibody concentrations were measured at 9 months in all children; 11PncTD induced a booster response to diphtheria in the control group. There was no negative interference from concomitant administration of new conjugate vaccines. In contrast, 11PncTD can boost the antibody response to the carrier proteins.
authors.affiliation: Research Institute for Tropical Medicine, Filinvest Corporate City, Alabang, Muntinlupa City 1780, Philippines. arnaldo_ocampo@hotmail.com
authors.forename: Arnaldo F
authors.initials: AF
authors.lastname: Ocampo
authors.forename: Christel
authors.initials: C
authors.lastname: Biltoft
authors.forename: Marilla
authors.initials: M
authors.lastname: Lucero
authors.forename: Rose-Marie
authors.initials: RM
authors.lastname: Olander
authors.forename: Juanita
authors.initials: J
authors.lastname: Ugpo
authors.forename: Kari
authors.initials: K
authors.lastname: Auranen
authors.forename: Anu
authors.initials: A
authors.lastname: Soininen
authors.forename: Hanna
authors.initials: H
authors.lastname: Nohynek
authors.forename: Helena
authors.initials: H
authors.lastname: Käyhty
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D004347:Drug Interactions; D018073:Haemophilus Vaccines / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D013745:Tetanus Toxoid / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C055753:Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate