title: Resolving polarized views: septin filaments do the twist.
abstract: Septins are a highly conserved family of filamentous GTPases required for cell division in a wide range of eukaryotic organisms. In a recent issue of Nature, Vrabioiu and Mitchison use polarized fluorescence microscopy to show that septin filaments undergo a highly orchestrated rotation, from a longitudinal to circumferential orientation, coincident with splitting of the septin ring during cytokinesis (Vrabioiu and Mitchison, 2006).
authors.affiliation: Program in Cell Biology, Hospital for Sick Children and Department of Biochemistry, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Steels
authors.forename: William S
authors.initials: WS
authors.lastname: Trimble
mesh_terms: D048749:Cytokinesis; D003598:Cytoskeletal Proteins / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D005454:Fluorescence Polarization; D020558:GTP Phosphohydrolases / Q000502:physiology*; D008856:Microscopy, Fluorescence; D012441:Saccharomyces cerevisiae / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*
chemical_list: D003598:Cytoskeletal Proteins; D029701:Saccharomyces cerevisiae Proteins; D020558:GTP Phosphohydrolases