[Effect of some non-steroidal antiinflammatory drugs and isomeric dihydroxy benzoic acids on the AAPH initiated degradation of crocin].
The authors examined the possible peroxyl radical scavanger effect of some non-steroidal antiinflammatory drugs and isomeric dihidroxy benzoic acids by means of the test based on 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-initiated degradation of crocin. The method is based on spectrophotometric determination of crocin, of which rate of AAPH-initiated degradation can be decreased in the presence of antioxidants with peroxyl radical scavanger activity. The authors studied the crocin degradation-inhibitory effect of phenacetin, paracetamol (acetaminophen), indomethacin, ibuprofen, diclofenac sodium, salicylic acid, salicylamide as well as the 2,3-, 2,4-, 2,5- and 3,4-dihydroxy substituted benzoic acids in 200 microM concentration. In the 60 minute studies the 2,3-, 2,5- and 3,4-dihydroxy benzoic acids proved to show the most effective degradation inhibitory effect. The results draw attention to the different antioxidant activity of salicylic acid and its hydroxylated metabolites (2,3- and 2,5-dihydroxy benzoic acids) formed under physiological conditions.
Fodor
Krisztina
K
Pécsi Tudományegyetem, Gyógyszerészi Kémiai Intézet, Pécs.
Léhman
Adrienn
A
Perjési
Pál
P
D000082:Acetaminophen / Q000737:chemistry; D000578:Amidines / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002338:Carotenoids / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D010615:Phenacetin / Q000737:chemistry; D012459:Salicylates / Q000737:chemistry*
D000578:Amidines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; D012459:Salicylates; D002338:Carotenoids; D000082:Acetaminophen; C046728:2,2'-azobis(2-amidinopropane); C029036:crocin; D010615:Phenacetin