Synthesis and fungicidal activity of N-2-(3-methoxy-4-propargyloxy) phenethyl amides. Part 3: stretched and heterocyclic mandelamide oomyceticides.
Novel analogues of mandipropamid have been designed and prepared. The synthetic approach to these stretched and heterocyclic mandelamides is outlined. Biological data demonstrate their high efficacy against important plant diseases like tomato and potato late blight (Phytophthora infestans De Bary) and grape downy mildew (Plasmopara viticola Berliner & de Toni). Structure-activity relationship studies are discussed.
Lamberth
Clemens
C
Syngenta AG, Crop Protection Research, Chemistry, Schwarzwaldallee 215, CH-4058 Basel, Switzerland. clemens.lamberth@syngenta.com
Kempf
Hans-Joachim
HJ
Kriz
Miroslav
M
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000737:chemistry; D008333:Mandelic Acids; D015394:Molecular Structure; D009868:Oomycetes; D010935:Plant Diseases
D000577:Amides; D005659:Fungicides, Industrial; D008333:Mandelic Acids; C010413:mandelamide