title: Regio- and stereoselective Ferrier reaction of O-1,3-dienyl acetals promoted by organoaluminum complexes.
abstract: The Ferrier reaction of O-1,3-dienyl acetals promoted by organoaluminum complexes such as methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide) (MAD) is shown to proceed with a high degree of regio- and stereoselectivity to afford the corresponding alpha-alkenyl-substituted beta-alkoxy aldehydes in good yields. The mechanistic origin of the high regiocontrolling ability of MAD is elucidated. This method, coupled with the easy availability of the requisite substrates, expands the synthetic scope of the Ferrier reaction. [reaction: see text].
authors.affiliation: Graduate School of Science and Technology, Niigata University, Niigata 950-2181, Japan. tayama@gs.niigata-u.ac.jp
authors.forename: Eiji
authors.initials: E
authors.lastname: Tayama
authors.forename: Wataru
authors.initials: W
authors.lastname: Isaka