Control of absolute helicity in single-stranded abiotic metallofoldamers.
Described is the design, synthesis, and characterization of abiotic, single-stranded metallofoldamers that adopt helical secondary structures upon metal complexation. The absolute helicity is determined by stereocenters at the ends of the structures and is enforced by the steric influence and hydrogen bonding ability of esters in the backbone of the foldamer. Folding of the structures is characterized in the solid state by X-ray crystallography and in solution by specific rotation, CD spectroscopy, and NMR spectroscopy.
Dong
Zhenzhen
Z
Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
Karpowicz
Richard J
RJ
Bai
Shi
S
Yap
Glenn P A
GP
Fox
Joseph M
JM
D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008667:Metalloproteins / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000737:chemistry*; D017433:Protein Structure, Secondary
D008667:Metalloproteins; D009942:Organometallic Compounds