Thio-isoglobotrihexosylceramide, an agonist for activating invariant natural killer T cells.
Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to alpha-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d. The biological assay showed that S-iGb3 demonstrates a much higher increase as a stimulatory ligand toward invariant natural killer T (iNKT) cells as compared to iGb3. [structure: see text].
Xia
Chengfeng
C
Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Zhou
Dapeng
D
Liu
Chengwen
C
Lou
Yanyan
Y
Yao
Qingjia
Q
Zhang
Wenpeng
W
Wang
Peng George
PG
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002460:Cell Line; D002518:Ceramides / Q000737:chemistry; D003713:Dendritic Cells / Q000187:drug effects; D005915:Globosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007694:Killer Cells, Natural / Q000187:drug effects*; D008024:Ligands; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D013237:Stereoisomerism; D013601:T-Lymphocytes / Q000187:drug effects*; D014281:Trihexosylceramides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000519:alpha-Galactosidase / Q000378:metabolism
D002518:Ceramides; D005915:Globosides; D007202:Indicators and Reagents; D008024:Ligands; D014281:Trihexosylceramides; C522749:thioisoglobotrihexosylceramide; D000519:alpha-Galactosidase