title: Measurement of physiological recovery from exacerbation of chronic obstructive pulmonary disease using within-breath forced oscillometry.
abstract: BACKGROUND
  Within-breath reactance from forced oscillometry estimates resistance via its inspiratory component (X(rs,insp)) and flow limitation via its expiratory component (X(rs,exp)).
  
  
  OBJECTIVE
  To assess whether reactance can detect recovery from an exacerbation of chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  39 subjects with a COPD exacerbation were assessed on three occasions over 6 weeks using post-bronchodilator forced oscillometry, arterial blood gases, spirometry including inspiratory capacity, symptoms and health-related quality of life (HRQOL).
  
  
  RESULTS
  Significant improvements were seen in all spirometric variables except the ratio of forced expiratory volume in 1 s (FEV(1)) to vital capacity, ranging in mean (SEM) size from 11.0 (2.2)% predicted for peak expiratory flow to 12.1 (2.3)% predicted for vital capacity at 6 weeks. There was an associated increase in arterial partial pressure of oxygen (PaO(2)). There were significant mean (SEM) increases in both X(rs,insp) and X(rs,exp) (27.4 (6.7)% and 37.1 (10.0)%, respectively) but no change in oscillometry resistance (R(rs)) values. Symptom scales and HRQOL scores improved. For most variables, the largest improvement occurred within the first week with spirometry having the best signal-to-noise ratio. Changes in symptoms and HRQOL correlated best with changes in FEV(1), PaO(2) and X(rs,insp).
  
  
  CONCLUSIONS
  The physiological changes seen following an exacerbation of COPD comprised both an improvement in operating lung volumes and a reduction in airway resistance. Given the ease with which forced oscillometry can be performed in these subjects, measurements of X(rs,insp) and X(rs,exp) could be useful for tracking recovery.
authors.affiliation: Department of Respiratory Medicine, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK. johnson77@btinternet.com
authors.forename: Martin K
authors.initials: MK
authors.lastname: Johnson
authors.forename: Malcolm
authors.initials: M
authors.lastname: Birch
authors.forename: Roger
authors.initials: R
authors.lastname: Carter
authors.forename: John
authors.initials: J
authors.lastname: Kinsella
authors.forename: Robin D
authors.initials: RD
authors.lastname: Stevenson
mesh_terms: D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D011788:Quality of Life; D012119:Respiration; D014797:Vital Capacity
chemical_list: D010100:Oxygen