Synthesis, cytotoxicity and clastogenicity of novel alpha-aminophosphonic acids.
Alpha-ethyl-N-(phosphonomethyl) glycine is synthesized and characterized by NMR and FAB spectroscopy. The cytotoxicity, clastogenic and antiproliferative effect of 3-ethyl-2-hydroxyl-2-oxo-1,4,2-oxazaphosphorinane, sodium salt of 3-ethyl-2-hydroxyl-2-oxo-1,4,2-oxazaphosphorinane, alpha-ethyl-alpha-N-(hydroxyethylamino) methylphosphonic acid, alpha-ethyl-N-(phosphonomethyl) glycine, alpha-ethyl-N-(phosphonomethyl) glycine isopropylammonium salt, glyphosate isopropylammonium salt are tested.
Naydenova
E
E
Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, Bulgaria.
Troev
K
K
Topashka-Ancheva
M
M
Hägele
G
G
Ivanov
I
I
Kril
A
A
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002417:Cattle; D016923:Cell Death; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002869:Chromosome Aberrations; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008810:Mice, Inbred C57BL; D008940:Mitotic Index; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*
D009153:Mutagens; D063065:Organophosphonates; C526579:alpha-ethyl-N-(phosphonomethyl)glycine; D005998:Glycine