Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser.
A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 microm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.
Sun
Chia-Wei
CW
National Taiwan University, Graduate Institute of Electro-Optical Engineering, Taipei, Taiwan.
Wang
Yih-Ming
YM
Lu
Long-Sheng
LS
Lu
Chih-Wei
CW
Hsu
I-Jen
IJ
Tsai
Meng-Tsan
MT
Yang
C C
CC
Kiang
Yean-Woei
YW
Wu
Chau-Chung
CC
D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation*; D007834:Lasers; D008858:Microscopy, Phase-Contrast / Q000295:instrumentation* / Q000379:methods; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods