Adiponectin versus angiotensin II: Key pathological role of their misbalance.
Kurata et al. report that an angiotensin II type-1 receptor blocker (ARB) inhibits obesity-induced hypoadiponectinemia in rats through inhibition of reactive oxygen species generation. Taken together with the recently reported functional interplay between adiponectin and angiotensin II, this suggests that adiponectin probably mediates tissue-protective effects of ARBs in obesity and metabolic syndrome.
Suzuki
H
H
Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Eguchi
S
S
D052242:Adiponectin / Q000502:physiology*; D000804:Angiotensin II / Q000502:physiology*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism / Q000503:physiopathology; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D052242:Adiponectin; D047228:Angiotensin II Type 1 Receptor Blockers; D017382:Reactive Oxygen Species; D000804:Angiotensin II