title: Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis.
abstract: The H2O, H2O/MeOH (1:1) extracts from the wood of Taxus yunnanensis showed a remarkable inhibitory effect on induced histamine release from the human basophilic cell line, KU812. The eleven constituents purified from the wood extracts of Taxus yunnanensis were tested by an in vitro histamine release inhibition assay. Among them, secoisolarciresinol and taxiresinol were found to show inhibitory activities. A new neolignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol, was isolated from the wood of Taxus yunnanensis.
authors.affiliation: Kobe Pharmaceutical University, Japan. j-koyama@kobepharma-u.ac.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Koyama
authors.forename: Izumi
authors.initials: I
authors.lastname: Morita
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hirai
authors.forename: Eriko
authors.initials: E
authors.lastname: Simamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nobukawa
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
mesh_terms: D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002072:Butylene Glycols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D002247:Carbon Isotopes; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D003903:Deuterium; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011409:Propylene Glycols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry*; D014934:Wood / Q000737:chemistry
chemical_list: C517195:2-(2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol; D018926:Anti-Allergic Agents; D002072:Butylene Glycols; D002247:Carbon Isotopes; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D010636:Phenols; D010936:Plant Extracts; D011409:Propylene Glycols; D043823:Taxoids; C483062:taxiresinol; D000001:Calcimycin; D003903:Deuterium; C060283:secoisolariciresinol