Efficient preparation of proline N-carboxyanhydride using polymer-supported bases.
[Structure: see text] A procedure for the preparation of proline N-carboxyanhydride in high yield and purity is described using polymer-supported tertiary amines. The polymer-supported amine can be recycled with a basic wash and filtration of the resin. The procedure facilitates the access to the efficient preparation of the polyproline polymer with potential therapeutic interest.
Gulín
Oscar P
OP
Institute for Research in Biomedicine, Parc Científic de Barcelona IRB-PCB, Universitat de Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain.
Rabanal
Francesc
F
Giralt
Ernest
E
D000812:Anhydrides / Q000138:chemical synthesis*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D000812:Anhydrides; D011108:Polymers; C517076:proline N-carboxyanhydride; D011392:Proline