Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia.
A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion.
Hulbert
Monica L
ML
Washington University School of Medicine, St. Louis, MO 63108, USA.
Scothorn
Douglas J
DJ
Panepinto
Julie A
JA
Scott
J Paul
JP
Buchanan
George R
GR
Sarnaik
Sharada
S
Fallon
Robert
R
Chu
Jen-Yih
JY
Wang
Winfred
W
Casella
James F
JF
Resar
Linda
L
Berman
Brian
B
Adamkiewicz
Thomas
T
Hsu
Lewis L
LL
Smith-Whitley
Kimberly
K
Mahoney
Donald
D
Woods
Gerald
G
Watanabe
Masayo
M
DeBaun
Michael R
MR
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000628:therapy*; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D013997:Time Factors