Isomerization-free allylic alkylations of terminal pi-allyl palladium complexes.
Chelated amino acid ester enolates are excellent nucleophiles for allylic alkylations. With these enolates, even terminal pi-allyl palladium complexes react without significant isomerization. This allows a transfer of the cis-olefin geometry from the substrate into the product. Chiral substrates also show a reasonably good 1,5-induction.
Krämer
Katja
K
Institut für Organische Chemie, Universität des Saarlandes, D-66123 Saarbrücken, Germany.
Kazmaier
Uli
U