title: Synthesis of polycyclic benzonitriles via a one-pot aryl alkylation/cyanation reaction.
abstract: A norbornene-mediated palladium-catalyzed tandem alkylation/cyanation sequence is described in which an alkyl-aryl bond and a nitrile-aryl bond are formed in one pot. A variety of sterically hindered, five-, six-, and seven-membered ring benzonitriles were synthesized in good yields from easily accessible starting materials.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada, M5S 3H6.
authors.forename: Brian
authors.initials: B
authors.lastname: Mariampillai
authors.forename: Dino
authors.initials: D
authors.lastname: Alberico
authors.forename: Valérie
authors.initials: V
authors.lastname: Bidau
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens