Targeting ubiquitin in cancers.
Ubiquitin (Ub) is a small protein modifier involved in cellular functions such as cell cycle, apoptosis, cell signalling, endocytosis, transcription and DNA repair. Ubiquitin operates as a reversible and highly versatile regulatory signal, which may be read and interpreted by an expanding number of Ub-binding domains (UBD). There is accumulating evidence that mutations or altered expression of ubiquitylating or de-ubiquitylating enzymes as well as of Ub-binding proteins affect crucial mediators of such functions and are found in several malignancies. Here we discuss how oncogenic alterations in the Ub system can be targeted by anti-cancer therapies.
Dikic
Ivan
I
Institute of Biochemistry II, Goethe University Hospital, Theodor-Stern-Kai 7, D-60590 Frankfurt (Main), Germany. ivan.dikic@biochem2.de
Crosetto
Nicola
N
Calatroni
Silvia
S
Bernasconi
Paolo
P
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001897:Boronic Acids / Q000627:therapeutic use; D000069286:Bortezomib; D002450:Cell Communication; D002453:Cell Cycle / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D007783:Lactones / Q000627:therapeutic use; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D011719:Pyrazines / Q000627:therapeutic use; D011758:Pyrroles / Q000627:therapeutic use; D025801:Ubiquitin / Q000037:antagonists & inhibitors / Q000235:genetics*
D000970:Antineoplastic Agents; D001897:Boronic Acids; D006360:Heat-Shock Proteins; D007783:Lactones; D011719:Pyrazines; D011758:Pyrroles; D025801:Ubiquitin; D000069286:Bortezomib; C475865:marizomib