Structural determination of three new germacrane-type sesquiterpene alcohols from curdione by microbial transformation.
Five germacrane-type sesquiterpene alcohols obtained from curdione (1) by microbial biotransformation were isolated. Their structures were characterized as (2R)-2beta-hydroxycurdione (2), 1alpha, 10beta-epoxy-11-hydroxycurdione (3), (2S)-2alpha, 11-dihydroxycurdione (4), 11,15-dihydroxycurdione (5) and (3R)-3alpha-hydroxycurdione (6) based on the extensive NMR studies. Among them, 4, 5 and 6 are new compounds.
Ma
Xiao-chi
XC
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road #38, Beijing 100083, P.R. China.
Zheng
Jian
J
Wu
Li-jun
LJ
Guo
De-an
DA
D000438:Alcohols / Q000737:chemistry*; D001711:Biotransformation; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism; D018514:Plant Structures; D012015:Reference Standards; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000378:metabolism
D000438:Alcohols; D045788:Sesquiterpenes, Germacrane; C504126:curdione