Influence of wall teichoic acid on lysozyme resistance in Staphylococcus aureus.
Staphylococcus aureus peptidoglycan (PG) is completely resistant to the hydrolytic activity of lysozyme. Here we show that modifications in PG by O acetylation, wall teichoic acid, and a high degree of cross-linking contribute to this resistance.
Bera
Agnieszka
A
Microbial Genetics, University of Tübingen, 72076 Tübingen, Germany.
Biswas
Raja
R
Herbert
Silvia
S
Kulauzovic
Emir
E
Weidenmaier
Christopher
C
Peschel
Andreas
A
Götz
Friedrich
F
D000107:Acetylation / Q000187:drug effects; D002473:Cell Wall / Q000737:chemistry; D024881:Drug Resistance, Bacterial; D006868:Hydrolysis / Q000187:drug effects; D009113:Muramidase / Q000378:metabolism / Q000494:pharmacology*; D010457:Peptidoglycan / Q000302:isolation & purification / Q000378:metabolism; D013211:Staphylococcus aureus / Q000737:chemistry / Q000187:drug effects*; D013682:Teichoic Acids / Q000737:chemistry / Q000378:metabolism*
D010457:Peptidoglycan; D013682:Teichoic Acids; D009113:Muramidase