title: A randomized, placebo-controlled study of donepezil in poststroke aphasia.
abstract: We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).
authors.affiliation: Centro de Investigaciones Médico-Sanitarias, University of Malaga School of Medicine, Spain. mberthier@terra.es
authors.forename: M L
authors.initials: ML
authors.lastname: Berthier
authors.forename: C
authors.initials: C
authors.lastname: Green
authors.forename: C
authors.initials: C
authors.lastname: Higueras
authors.forename: I
authors.initials: I
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Hinojosa
authors.forename: M C
authors.initials: MC
authors.lastname: Martín
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000328:Adult; D001037:Aphasia / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D000077265:Donepezil; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007189:Indans / Q000008:administration & dosage*; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D018697:Nootropic Agents / Q000008:administration & dosage; D010880:Piperidines / Q000008:administration & dosage*; D010919:Placebos; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D013070:Speech Therapy; D020521:Stroke / Q000150:complications* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D010919:Placebos; D000077265:Donepezil; D000109:Acetylcholine