title: Parkinsonism in type I Gaucher's disease.
abstract: The majority of patients with type I Gaucher's disease never develop neurological signs or symptoms. However, several case reports of Parkinson's disease associated with type I Gaucher's disease have been published, suggesting a genetic link between the two diseases. Hence, detailed clinical investigations are required when the two diseases occur simultaneously, in order to determine whether this is coincidental or whether a true association is present. We present a Japanese man in whom parkinsonism was associated with type I Gaucher's disease. Findings of brain positron tomography (PET) and metaiodobenzylguanidine (MIBG) cardiac scintigraphy are presented.
authors.affiliation: Department of Neurology, Saitama Medical University.
authors.forename: Kaori
authors.initials: K
authors.lastname: Itokawa
authors.forename: Naotoshi
authors.initials: N
authors.lastname: Tamura
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kawai
authors.forename: Kunio
authors.initials: K
authors.lastname: Shimazu
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
mesh_terms: D019797:3-Iodobenzylguanidine; D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18; D005776:Gaucher Disease / Q000150:complications* / Q000235:genetics; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine