Semisynthesis of isetexane diterpenoid analogues and their cytotoxic activity.
Isetexane diterpene analogues were semisynthesized from demethylsalvicanol isolated from Perovskia abrotanoides (Labiatae). The structure and cytotoxic activity relationships (SAR) of the natural parent diterpene, demethylsalvicanol, and its semisynthetic analogues were studied by using P388 murine leukemia cells.
Aoyagi
Yutaka
Y
School of Pharmacy, Tokyo University of Pharmacy & Life Science, Hachioji, Tokyo, Japan.
Takahashi
Yoshinao
Y
Fukaya
Haruhiko
H
Takeya
Koichi
K
Aiyama
Ritsuo
R
Matsuzaki
Takeshi
T
Hashimoto
Shusuke
S
Kurihara
Teruo
T
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D019686:Lamiaceae / Q000737:chemistry*; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D004224:Diterpenes; C516763:demethylsalvicanol