title: Different roles of the two high-oxygen-affinity terminal oxidases of Brucella suis: Cytochrome c oxidase, but not ubiquinol oxidase, is required for persistence in mice.
abstract: The survival of Brucella suis mutant strains in mice demonstrated different roles of the two high-oxygen-affinity terminal oxidases. The cbb3-type cytochrome c oxidase was essential for chronic infection in oxygen-deficient organs. Lack of the cytochrome bd ubiquinol oxidase led to hypervirulence of bacteria, which could rely on nitrite accumulation inhibiting the inducible nitric oxide synthase of the host.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U431, Montpellier, F-34095 France.
authors.forename: Maria Pilar
authors.initials: MP
authors.lastname: Jiménez de Bagüés
authors.forename: Séverine
authors.initials: S
authors.lastname: Loisel-Meyer
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Liautard
authors.forename: Véronique
authors.initials: V
authors.lastname: Jubier-Maurin
mesh_terms: D000818:Animals; D041021:Brucella suis / Q000201:enzymology / Q000472:pathogenicity*; D002006:Brucellosis / Q000201:enzymology*; D004195:Disease Models, Animal; D003576:Electron Transport Complex IV / Q000378:metabolism*; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010088:Oxidoreductases / Q000378:metabolism*
chemical_list: D010088:Oxidoreductases; C432586:ubiquinol oxidase; D003576:Electron Transport Complex IV