title: [The genetic engineering animal models of retinoblastoma].
abstract: The article summarized the latest progress of retinoblastoma animal models using transgenetic engineering technology, and discussed the mechanism of Rb production. According to the the established animal models using current genetic engineering, the dysfunction of Rb1 gene is not the only gene in response to the development of Rb, multiple genes abnormal are required.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Yang
authors.forename: Yong-ping
authors.initials: YP
authors.lastname: Li
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D016161:Genes, Retinoblastoma; D005818:Genetic Engineering; D051379:Mice; D018345:Mice, Knockout; D019572:Retinal Neoplasms / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics*