title: [Comparative study of the effects of Gypsum Fibrosum and Gypsum Fibrosum Preparatum in promoting granulation].
abstract: OBJECTIVE
  To investigate the effects of Gypsum Fibrosum and Gypsum Fibrosum Preparatum in promoting granulation.
  
  
  METHODS
  The wounds of muscle layer were produced in rats by using surgical operation. Two round wounds, with diameter about 1.5 cm, were cut at the depilatory area of two sides of the back of each rat, with an interval of 2 cm, deep to muscle layer, and the thickness of the knife wound of muscle layer was about 0.15 cm. Forty SD rats with the wounds were randomly divided into 4 groups: untreated group, beifuji-treated group, Gypsum Fibrosum-treated group and Gypsum Fibrosum Preparatum-treated group, with 10 rats in each group. Then the wounds were sprinkled with powders of Gypsum Fibrosum and Gypsum Fibrosum Preparatum, or sprayed with beifuji solution, respectively. The healing state of granulation tissues of the wounds was observed at the eighth and fourteenth day respectively.
  
  
  RESULTS
  The number of fibroblasts, the number of capillary tubes and the area of capillary tubes in granulation tissue of wounds in the Gypsum Fibrosum Preparatum-treated group were significantly higher than those in the untreated group and Gypsum Fibrosum-treated group (P<0.01). There were no statistical differences between the Gypsum Fibrosum Preparatum-treated group and the beifuji-treated group. However, Gypsum Fibrosum-treated group showed no obvious differences compared to the untreated group (P>0.05).
  
  
  CONCLUSIONS
  Gypsum Fibrosum Preparatum can accelerate the formation of collagenoblast and micrangium in wounds, and the proliferation of granulation tissues, thus promoting the skin wounds to healing. The effect of Gypsum Fibrosum is changed after being calcined, and Gypsum Fibrosum Preparatum has obvious effect in promoting granulation.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China. lixiang_8182@163.com
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Yuan-Fen
authors.initials: YF
authors.lastname: Liu
authors.forename: Xiao-Ren
authors.initials: XR
authors.lastname: Xiang
authors.forename: Yi-Biao
authors.initials: YB
authors.lastname: Zhou
authors.forename: Zhi-Lei
authors.initials: ZL
authors.lastname: Zhang
mesh_terms: D002133:Calcium Sulfate / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006097:Granulation Tissue / Q000187:drug effects*; D028321:Plant Preparations / Q000494:pharmacology; D011897:Random Allocation; D012883:Skin Ulcer / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D028321:Plant Preparations; D002133:Calcium Sulfate