title: [Case of rapid progressive interstitial pneumonia associated with primary Sjogren syndrome].
abstract: A 72-year-old woman with a dry cough and dyspnea on exertion was admitted to our hospital. A chest radiograph showed reticular opacities and volume loss in both lower lung fields. She was troubled with xerostomia and her laboratory test showed positive reaction for anti SS-A and SS-B antibody. Labial biopsy led to a diagnosis of primary Sjogren's syndrome (pSjS). Lung biopsy specimens obtained by video-assisted thoracoscopic surgery (VATS) revealed interstitial pneumonia. On the sixth postoperative day, hypoxemia acutely worsened and her chest radiograph showed widespread diffuse ground-glass attenuation. A diagnosis of acute exacerbation was made, and steroid and immunosuppressive therapy was started. In spite of intensive therapy, she died due to respiratory failure. We report a rare case of interstitial pneumonia with pSjS resulting in acute exacerbation.
authors.affiliation: Department of Respiratory Medicine, Seirei Mikatahara Hospital.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Naruse
authors.forename: Naoki
authors.initials: N
authors.lastname: Inui
authors.forename: Hideki
authors.initials: H
authors.lastname: Yasui
authors.forename: Masato
authors.initials: M
authors.lastname: Karayama
authors.forename: Sawa
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Eriko
authors.initials: E
authors.lastname: Muramatsu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Uto
authors.forename: Satoru
authors.initials: S
authors.lastname: Morita
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakano
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Enomoto
authors.forename: Shiro
authors.initials: S
authors.lastname: Imokawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
authors.forename: Kingo
authors.initials: K
authors.lastname: Chida
mesh_terms: D000368:Aged; D001706:Biopsy / Q000009:adverse effects; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000175:diagnosis; D012131:Respiratory Insufficiency / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis; D020775:Thoracic Surgery, Video-Assisted / Q000009:adverse effects; D014057:Tomography, X-Ray Computed