title: Microcystic meningioma in a dolphin (Delphinus delphis): immunohistochemical and ultrastructural study.
abstract: A wild common dolphin was found stranded on the French Atlantic coast. At necropsy, an intracranial grey- to tan-coloured mass (7 x 5 x 4 cm) was found at the right cerebellopontine angle, compressing the right cerebellar hemisphere, the brainstem and the occipital lobe of the right cerebral hemisphere. Microscopically, the tumour was composed of small lobules of polygonal to elongated neoplastic cells with multifocal areas of stellate and vacuolated cells. Neoplastic cells strongly expressed vimentin, S-100 protein and neuron-specific enolase. They were rarely positive for cytokeratin. Ultrastructurally, the neoplastic cells displayed all the diagnostic features of meningiomas and in some areas showed long cytoplasmic processes delimiting extracellular spaces. The immunohistochemical and ultrastructural features were consistent with the histopathological diagnosis of a microcystic meningioma. This is the first report of a meningioma in dolphins or in any other cetacean species.
authors.affiliation: Unité d'Anatomie Pathologique, UMR 703 INRA/ENVN, Ecole Nationale Vétérinaire de Nantes, BP 40706 Nantes Cedex 03, France.
authors.forename: J
authors.initials: J
authors.lastname: Miclard
authors.forename: K
authors.initials: K
authors.lastname: Mokhtari
authors.forename: G
authors.initials: G
authors.lastname: Jouvion
authors.forename: B
authors.initials: B
authors.lastname: Wyrzykowski
authors.forename: O
authors.initials: O
authors.lastname: Van Canneyt
authors.forename: M
authors.initials: M
authors.lastname: Wyers
authors.forename: M A
authors.initials: MA
authors.lastname: Colle
mesh_terms: D000818:Animals; D004289:Dolphins; D005260:Female; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D008579:Meningioma / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin; D010751:Phosphopyruvate Hydratase