Mechanisms controlling venom expulsion in the western diamondback rattlesnake, Crotalus atrox.
Although many studies have documented variation in the amount of venom expended during bites of venomous snakes, the mechanistic source of this variation remains uncertain. This study used experimental techniques to examine how two different features of the venom delivery system, the muscle surrounding the venom gland (the Compressor Glandulae in the rattlesnake) and the fang sheath, could influence venom flow in the western diamondback rattlesnake, Crotalus atrox. Differential contraction of the Compressor Glandulae explained only approximately 30% of the variation in venom flow. Lifting (compression) of the fang sheath as occurs during a normal strike produced marked increases in venom flow; these changes were closely correlated and exceed in magnitude by almost 10 x those recorded from the Compressor Glandulae alone. These results suggest that variation in these two aspects of the venom delivery system--both in terms of magnitude and temporal patterning--explain most of the observed variation in venom injection. The lack of functional or mechanical links between the Compressor Glandulae and the fang sheath, and the lack of skeletal or smooth muscle within the fang sheath, make it unlikely that variation in venom flow is under direct neural control. Instead, differential venom injection results from differences in the pressurization by the Compressor Glandulae, the gate keeping effects of the fang sheath and enclosed soft-tissue chambers, and by differences in the pressure returned by peripheral resistance of the target tissue.
Young
Bruce A
BA
School of Biological Sciences, Washington State University, Pullman, Washington 99164-4236, USA. bruce.young@washburn.edu
Kardong
Kenneth V
KV
D000818:Animals; D001696:Biomechanical Phenomena; D003435:Crotalid Venoms; D017839:Crotalus / Q000502:physiology*; D004576:Electromyography; D005088:Exocrine Glands / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D014070:Tooth / Q000502:physiology*
D003435:Crotalid Venoms