Inhibition of restraint-induced neuroendocrine and serotonergic responses by buspirone in rats.
The effects of buspirone (0.5 mg/kg) on the neuroendocrine and serotonergic responses to stress were monitored in rats. Exposure to 2-h of restraint stress increased circulating levels of corticosterone, noradrenaline and glucose. The metabolism of 5-hydroxytryptamine (5-HT; serotonin) increased in the brain. Prior administration of buspirone did not alter levels of corticosterone, noradrenaline and glucose in unrestrained rats, but inhibited stress-induced increase in the activity of hypothalamic-pituitary-adrenal (HPA) axis and circulating levels of glucose. Restraint-induced rise in brain 5-HT and 5-hydroxyindole-acetic acid (5-HIAA) was also attenuated by buspirone. Unrestrained animals injected with buspirone also exhibited a decrease in brain 5-HIAA concentration. The findings are discussed in the context of the role of somatodendritic 5-HT(1A) receptors in responses to stress.
Samad
Noreen
N
Department of Biochemistry, Neurochemistry, Biochemical Neuropharmacology, Research Unit, University of Karachi, Karachi-75270, Pakistan. noreensamad_ku@yahoo.com
Perveen
Tahira
T
Haider
Saida
S
Haleem
Mohammad  A
M
Haleem
Darakhshan J
DJ
D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D003345:Corticosterone / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D007266:Inhibition, Psychological; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*
D012701:Serotonin; D005947:Glucose; D002065:Buspirone; D003345:Corticosterone; D009638:Norepinephrine