title: Eosinophilic granulomatous gastroenterocolitis and hepatitis in a 1-year-old male Siberian Husky.
abstract: A case of eosinophilic granulomatous gastroenterocolitis and hepatitis in a 1-year-old male Siberian Husky is described. The dog presented with a history of diarrhea, weakness, lethargy, and anorexia of several months' duration. Hematologic and biochemical examinations, abdominal ultrasonography, computer tomography, and exploratory laparotomy were performed. Histopathologic examination of full-thickness biopsies from the gastrointestinal tract and liver revealed the presence of eosinophilic granulomatous lesions in the submucosa and tunica muscularis of stomach, jejunum, ileum, colon, and liver. Infectious agents were not detected by light microscopic and electron microscopic examination or by immunohistochemistry. On the basis of the findings, it is concluded that the disease in this dog represents an unusual manifestation of chronic idiopathic inflammatory bowel disease.
authors.affiliation: Department of Pathology, School of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.
authors.forename: G D
authors.initials: GD
authors.lastname: Brellou
authors.forename: S
authors.initials: S
authors.lastname: Kleinschmidt
authors.forename: F
authors.initials: F
authors.lastname: Meneses
authors.forename: I
authors.initials: I
authors.lastname: Nolte
authors.forename: M
authors.initials: M
authors.lastname: Hewicker-Trautwein
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004803:Eosinophilic Granuloma / Q000473:pathology / Q000662:veterinary*; D005759:Gastroenteritis / Q000473:pathology / Q000662:veterinary*; D006520:Hepatitis, Animal / Q000473:pathology*; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male