The oncogenic potential of growth hormone.
A growing body of recent literature indicates that in addition to an essential role in growth and development, growth hormone may also play a more sinister role in oncogenic transformation and neoplastic progression. Here we review the accumulating evidence implicating growth hormone in the development and progression of cancer and describe what is known of the mechanisms utilised by this hormone in neoplastic transformation.
Perry
Jo K
JK
The Liggins Institute and the National Research Centre for Growth and Development, University of Auckland, 2-6 Park Avenue, Grafton, Private Bag 92019, Auckland 1023, New Zealand.
Emerald
B Starling
BS
Mertani
Hichem C
HC
Lobie
Peter E
PE
D000172:Acromegaly / Q000150:complications; D000818:Animals; D019898:Autocrine Communication; D001943:Breast Neoplasms / Q000209:etiology; D002471:Cell Transformation, Neoplastic; D004195:Disease Models, Animal; D005260:Female; D013006:Growth Hormone / Q000235:genetics / Q000502:physiology*; D019382:Human Growth Hormone / Q000235:genetics / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000628:therapy
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone