Acute generalized exanthematous pustulosis induced by nimesulide.
Nimesulide is a new nonsteroidal anti-inflammatory (NSAID) drug with antipyretic and analgesic properties. Because of its favorable tolerability profile it appears to be a preferred alternative, especially in NSAID-sensitive patients. We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide. To the best of our knowledge there have been no previous reports of AGEP induced by the ingestion of nimesulide in the medical literature. Nimesulide should be added to the list of agents associated with this serious adverse drug reaction.
Teixeira
M
M
Department of Dermatology, Hospital Geral de Santo António, Porto, Portugal. martamotateixeira@mail.telepac.pt
Silva
E
E
Selores
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D010328:Patch Tests; D010612:Pharyngitis / Q000188:drug therapy; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013449:Sulfonamides / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; C012655:nimesulide