Switchable dual binding mode molecular shuttle.
[Structure: see text] Protonation controls the location of a dual binding mode macrocycle in a [2]rotaxane. In the neutral form, amide-amide hydrogen bonds hold the macrocycle over a dipeptide residue; when the thread is protonated, polyether-ammonium cation interactions dominate and the macrocycle changes position.
Leigh
David A
DA
University of Edinburgh, School of Chemistry, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK. david.leigh@ed.ac.uk
Thomson
Andrew R
AR