[Adjuvants--essential components of new generation vaccines].
Adjuvants are essential components of vaccines that augment an immunological reaction of organism. New vaccines based on recombinant proteins and DNA, are more save than traditional vaccines but they are less immunogenic. Therefore, there is an urgent need for the development of new, improved vaccine adjuvants. There are two classes of adjuvants: vaccine delivery systems (e.g. emulsions, microparticles, immune-stimulating complexes ISCOMs, liposomes) and immunostimulatory adjuvants (e.g. lipopolysaccharide, monophosphoryl lipid A, CpG DNA, or muramylpeptides). The discovery of more potent and safer adjuvants may allow to development better prophylactic and therapeutic vaccines against chronic infectious (e.g., HSV, HIV, HCV, HBV, HPV, or Helicobacter pylori) and noninfectious diseases as multiple sclerosis, insulin-dependent diabetes, rheumatoid arthritis, allergy and tumors (e.g., melanoma, breast, or colon cancer).
Dzierzbicka
Krystyna
K
Katedra Chemii Organicznej, Politechnika Gdańska, Gdańsk. kd@chem.pg.gda.pl
Kołodziejczyk
Aleksander M
AM
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D016882:ISCOMs / Q000627:therapeutic use; D008050:Lipid A / Q000031:analogs & derivatives / Q000627:therapeutic use; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D017778:Vaccines, Combined / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
D000276:Adjuvants, Immunologic; D000277:Adjuvants, Pharmaceutic; D001428:Bacterial Vaccines; D016882:ISCOMs; D008050:Lipid A; D014612:Vaccines; D017778:Vaccines, Combined; D019444:Vaccines, DNA; D015164:Vaccines, Inactivated; C048436:monophosphoryl lipid A