Structural impact of coordinating a helical 2,6-pyridyl diamide with divalent metals.
[Structure: see text] The structural consequences of coordinating 2,6-bis[2-((4S)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl)phenyl]carbamoylpyridines, 2, with divalent metals such as Cu(II), Ni(II), and Zn(II) are reported. Metal coordination occurs under mild conditions in a manner that preserves the helical bias of the parent ligand in the solid state and in solution. 1H NMR line-shape analysis indicates that metal coordination increases the helical interconversion barrier, thus rigidifying the dynamic helicity of 2.
Preston
Adam J
AJ
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Gallucci
Judith C
JC
Parquette
Jon R
JR
D000577:Amides / Q000737:chemistry*; D002413:Cations, Divalent; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000577:Amides; D002413:Cations, Divalent; D003300:Copper; D009532:Nickel; D015032:Zinc