Effects of in vitro maturation of monkey oocytes on their developmental capacity.
The study of in vitro maturation (IVM) of rhesus monkey oocytes has important implications for biomedical research and human infertility treatment. In vitro-matured rhesus monkey oocytes show much less developmental potential than IVM oocytes of other species. Since about 1980 when rhesus monkey IVM, in vitro fertilization (IVF) and in vitro embryo culture (IVC) systems were established, numerous efforts have been made to improve the developmental competence of oocytes and to understand the mechanisms regulating oocyte maturation. This review describes recent progress in this area, particularly the effects of factors such as steroid hormones, energy substrates, amino acids, ovarian follicle status, maternal age and breeding season on the developmental competence, gene expression patterns and genome integrity of rhesus IVM oocytes.
Zheng
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Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Building 50, Rm 3132, 9000 Rockville Pike, Bethesda, MD 20892-8028, USA. zhengp@mail.nih.gov
D000818:Animals; D047108:Embryonic Development; D004734:Energy Metabolism; D005260:Female; D005307:Fertilization in Vitro / Q000662:veterinary; D008253:Macaca mulatta / Q000502:physiology*; D008423:Maternal Age; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology; D011247:Pregnancy