Effects of Yiweining Recipe on expressions of metalloproteinase-2 and cyclooxygenase-2 mRNAs in ectopic endometrium of rats with endometriosis.
OBJECTIVE
To explore the effects of Yiweining Recipe (YWNR), a compound Chinese herbal medicine, on expressions of metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) mRNAs in rats with endometriosis (EM).


METHODS
Operational self-transplantation was applied in establishing the rat models. Detection of MMP-2 and COX-2 mRNAs was conducted with hybridization in situ.


RESULTS
There were significant differences in the expressions of MMP-2 and COX-2 mRNAs between the untreated group and the high-dose YWNR-treated group. YWNR could reduce the expressions of MMP-2 and COX-2 mRNAs.


CONCLUSIONS
YWNR can treat EM through reducing the positive expressions of MMP-2 and COX-2 mRNAs.
Qu
Fan
F
Department of Gynecology and Obstetrics, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province 150040, China.
Zhou
Jue
J
Yang
Dong-Xia
DX
Ma
Wen-Guang
WG
Ma
Bao-Zhang
BZ
D000818:Animals; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008517:Phytotherapy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014591:Uterine Diseases / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics
D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; C527177:yiweining; D051546:Cyclooxygenase 2; D020778:Matrix Metalloproteinase 2