[The role of IL-6/sIL-6R complex and its natural inhibitor sgp130 in modulation of inflammatory process].
IL-6/sIL-6R complex belongs to one of the most pleiotropic ligand-receptor system. Participating in leukocytes migration and apoptosis it plays a crucial role in modulation of inflammatory process. Firstly it contributes to resolution of acute inflammatory response regulating a maintaining of organism's homeostasis. Secondly it is a main factor responsible for transition between acute and chronic inflammatory reaction, that underlies the pathogenesis of chronic inflammatory diseases. Presented work focus on the IL-6/sIL-6R structure, function, formation, mechanism of action as well as the role of its natural inhibitor sgp130 in mentioned processes.
Augustyniak
Daria
D
Pracownia Immunologii, Zakład Mikrobiologii, Instytut Genetyki i Mikrobiologii, Uniwersytet Wrocławski, Wrocław. august@microb.uni.wroc.pl
Majkowska-Skrobek
Grayna
G
Basiewicz-Worsztynowicz
Barbara
B
Jankowski
Adam
A
D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D003424:Crohn Disease / Q000276:immunology; D050822:Cytokine Receptor gp130 / Q000037:antagonists & inhibitors* / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D007249:Inflammation / Q000276:immunology*; D015850:Interleukin-6 / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D012995:Solubility
C494199:IL6ST protein, human; D007155:Immunologic Factors; D015850:Interleukin-6; D050822:Cytokine Receptor gp130