[Sirt1: a novel adipocyte and myocyte regulatory factor].
Sirt1 (Sirtuin type 1), a member of the conserved sirtuin family, is a NAD+ -dependent histone deacetylase. It is intimately related to cell proliferation, differentiation, apoptosis, and metabolism. Its role in senescence and metabolism has recently come to light. Sirt1 promotes fat mobilization in white adipocytes by repressing PPARgamma and inhibits myoblast differentiation by down-regulating muscle gene expression. Therefore, Sirt1 is not only an important longevity factor, but also may play a key modulatory role in animal fat deposition and muscle development.
Bai
Liang
L
Laboratory of Animal Fat Deposition and Muscle Development, Northwest A & F University, Yangling 712100, China. bailiang0922@gmail.com
Pang
Wei-Jun
WJ
Yang
Gong-She
GS
D017667:Adipocytes / Q000166:cytology* / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D016922:Cellular Senescence; D006801:Humans; D008053:Lipid Mobilization; D032342:Muscle Cells / Q000166:cytology* / Q000378:metabolism*; D037761:Sirtuins / Q000737:chemistry / Q000378:metabolism*
D037761:Sirtuins