title: Synthesis of cyclic peptides constrained with biarylamine linkers using Buchwald-Hartwig C-N coupling.
abstract: In this paper, we describe the synthesis of conformationally constrained cyclic peptides with biarylamine linkers for peptidomimetics using palladium-catalyzed intramolecular Buchwald-Hartwig C-N coupling. We have prepared a variety of di-, tri-, and tetrapeptides (16-22-membered) in good yields using this reaction.
authors.affiliation: Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500 049, A.P., India.
authors.forename: V
authors.initials: V
authors.lastname: Balraju
authors.forename: Javed
authors.initials: J
authors.lastname: Iqbal
mesh_terms: D000588:Amines / Q000737:chemistry*; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D010456:Peptides, Cyclic