Phosphaturic mesenchymal tumor with symptoms related to osteomalacia that appeared one year after tumorectomy.
A 45-year-old man was admitted to our hospital because of bone pain and hypophosphatemia. He had undergone surgery 2 years previously for a "benign unclassified mesenchymal tumor" in the skull, but there were no clinical symptoms related to osteomalacia. His laboratory examination revealed low serum phosphate, high alkaline phosphatase, and normal calcium levels. The diagnosis of tumor-induced osteomalacia due to phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT) was made by re-examining the pathologic specimens. Oral supplementation with phosphate and 1-25-dihydroxyvitamin D relieved his clinical symptoms and laboratory values returned to normal. However, subcutaneous administration of octreotide had no clinical effect. Clinicians and pathologists should be aware of the existence of PMTMCT especially nonphosphaturic or asymptomatic variants of this disorder.
Yoshioka
Katsunobu
K
Department of Internal Medicine, Osaka City General Hospital, Osaka.
Nagata
Rie
R
Ueda
Mami
M
Yamaguchi
Toshimasa
T
Konishi
Yoshio
Y
Hosoi
Masayuki
M
Inoue
Takeshi
T
Yamanaka
Kazuhiro
K
Iwai
Yoshiyasu
Y
Sato
Toshihiko
T
D003388:Cranial Fossa, Posterior / Q000473:pathology* / Q000601:surgery; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000188:drug therapy / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008637:Mesenchymoma / Q000150:complications* / Q000601:surgery / Q000652:urine; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D015282:Octreotide / Q000008:administration & dosage / Q000627:therapeutic use; D010018:Osteomalacia / Q000188:drug therapy / Q000209:etiology* / Q000652:urine; D010710:Phosphates / Q000627:therapeutic use; D016634:Radiosurgery; D019292:Skull Base Neoplasms / Q000150:complications* / Q000601:surgery / Q000652:urine; D014807:Vitamin D / Q000031:analogs & derivatives / Q000627:therapeutic use
D010710:Phosphates; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D015282:Octreotide