Evaluation of a novel biomaterial for intrasubstance muscle laceration repair.
The authors compare the effects of small intestinal submucosa (SIS) treatment to suture repair with respect to histologic and functional outcomes for complete muscle lacerations in a rabbit model. The authors hypothesized that SIS treatment of full-thickness muscle belly lacerations would significantly improve muscle function, strength, and regeneration compared to the current standard-of-care treatment. Muscle belly lacerations were created in the extensor digitorum longus (EDL) of both hind limbs of each rabbit. After randomization, lacerations were left unrepaired (n = 48) or repaired using a 4-0 Prolene modified Kessler stitch (n = 48). A flap of SIS graft was sutured into half (n = 24 each) of the repaired and unrepaired muscles forming four study groups. Suture repair with SIS augmentation of complete muscle lacerations resulted in healed tissue that most closely resembled normal muscle in terms of morphology and function when compared to current standard-of-care treatments. Active force production in this group reached 79% of uninjured controls 12 weeks after surgery. SIS may have important clinical advantages over suture repair alone and warrants further clinical study.
Crow
Bradley D
BD
Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri 65211, USA.
Haltom
J Douglas
JD
Carson
William L
WL
Greene
Walter B
WB
Cook
James L
JL
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D022125:Lacerations / Q000601:surgery*; D008422:Materials Testing; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery*; D011817:Rabbits; D020127:Recovery of Function; D013552:Swine
D001672:Biocompatible Materials