Inhibition of hypusine biosynthesis in plasmodium: a possible, new strategy in prevention and therapy of malaria.
The increasing drug resistance of malaria parasites against chemotherapeutics enforces new strategies in finding new drugs. Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A).
Kaiser
A
A
Institute for Medical Parasitology, D-53105 Bonn, Germany. annette.kaiser@guc.edu.eg
Ulmer
D
D
Goebel
T
T
Holzgrabe
U
U
Saeftel
M
M
Hoerauf
A
A
D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology*; D010961:Plasmodium / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism
D000977:Antiparasitic Agents; D011073:Polyamines; C100028:hypusine; D008239:Lysine