title: Epidemic outbreaks on structured populations.
abstract: Our chances to halt epidemic outbreaks rely on how accurately we represent the population structure underlying the disease spread. When analysing global epidemics this force us to consider metapopulation models taking into account intra- and inter-community interactions. Here I introduce and analyze a metapopulation model which accounts for several features observed in real outbreaks. First, I demonstrate that depending on the intra-community expected outbreak size and the fraction of social bridges the epidemic outbreaks die out or there is a finite probability to observe a global epidemics. Second, I show that the global scenario is characterized by resurgent epidemics, their number increasing with increasing the intra-community average distance between individuals. Finally, I present empirical data for the AIDS epidemics supporting the model predictions.
authors.affiliation: The Simons Center for Systems Biology, Institute for Advanced Study, Einstein Dr, Princeton, NJ 08540, USA. vazquez@ias.edu
authors.forename: Alexei
authors.initials: A
authors.lastname: Vazquez
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000453:epidemiology* / Q000635:transmission; D004196:Disease Outbreaks; D018562:Disease Transmission, Infectious; D006801:Humans; D015994:Incidence; D008433:Mathematics; D008954:Models, Biological; D011157:Population Dynamics; D014481:United States / Q000453:epidemiology