Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea.
The influences of different arabinogalactan-proteins (AGPs) on proliferation and IgM-production of mouse lymphocytes as well as nitrite- and IL6-production of mouse macrophages were investigated in vitro. AGPs have been isolated and purified from roots of Baptisia tinctoria and Echinacea pallida and suspension culture of Echinacea purpurea. Comparing the AGPs, there are differences with regard to fine structure as well as to activities. AGPs from roots of B. tinctoria and E. pallida show high activity in all test systems. AGP from cell culture of E. purpurea shows no influence on proliferation of mouse lymphocytes, only weak influence on the IgM-production of mouse lymphocytes and weak stimulation of nitrite- and IL6-production in alveolar mouse macrophage culture.
Classen
B
B
Department of Pharmaceutical Biology, Institute of Pharmacy, University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany. bclassen@pharmazie.uni-kiel.de
Thude
S
S
Blaschek
W
W
Wack
M
M
Bodinet
C
C
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D020900:Echinacea / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D007075:Immunoglobulin M / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D016676:Macrophages, Alveolar / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009088:Mucoproteins / Q000302:isolation & purification / Q000494:pharmacology*; D009573:Nitrites / Q000378:metabolism; D010940:Plant Proteins / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
D007075:Immunoglobulin M; D015850:Interleukin-6; D009088:Mucoproteins; D009573:Nitrites; D010940:Plant Proteins; C006619:arabinogalactan proteins