title: Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy.
abstract: OBJECTIVE
  The significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy (PD) has not been well understood. The aim of this study was to clarify this issue.
  
  
  METHODS
  Clinical records of 60 Japanese patients who underwent PD were reviewed retrospectively. Patients were divided into two groups, normal (n=33) and low (n=27) pancreatic exocrine function, according to the preoperative value of N-benzoyl-L-tyrosyl-p-aminobenzoic acid excretion test (normal value >70%). We compared the perioperative events and nutritional status between the two groups.
  
  
  RESULTS
  The preoperative and operative characteristics between the two groups were not significantly different. Postoperative pancreatic juice output from the remnant pancreas during the initial 7 days after PD was greater (1145 +/- 618 vs. 741 +/-612mL, P=0.02), and the prevalence of pancreatic anastomotic leakage was higher (10/23, 30% vs. 1/27, 4%, P=0.008) in the group with normal pancreatic exocrine function than that in the insufficient group. Perioperative body mass index and serum albumin concentration, which reflect the nutritional status of patients, were significantly lower in the group with low pancreatic exocrine function (P=0.007 and 0.04, respectively).
  
  
  CONCLUSIONS
  Surgeons should pay more attention to pancreatic anastomotic leakage in patients with normal pancreatic exocrine function after PD. On the other hand, in patients with insufficient exocrine function, perioperative nutritional support should be considered.
authors.affiliation: Department of Surgery, Saga University Faculty of Medicine, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: Kenji
authors.initials: K
authors.lastname: Kitahara
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsuyama
authors.forename: Tomonori
authors.initials: T
authors.lastname: Shimonishi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakafusa
authors.forename: Kohji
authors.initials: K
authors.lastname: Miyazaki
mesh_terms: D000368:Aged; D015992:Body Mass Index; D004066:Digestive System Diseases / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D046790:Pancreas, Exocrine / Q000503:physiopathology*; D010190:Pancreatic Neoplasms / Q000503:physiopathology / Q000601:surgery; D016577:Pancreaticoduodenectomy / Q000009:adverse effects