title: Early-onset scleral and corneal ectasias following low-dose mitomycin-C-augmented trabeculectomy in a uveitic glaucoma patient.
abstract: A case of early-onset sclerolimbal ectasia following low-dose topical mitomycin C application during uveitic glaucoma surgery is reported. Intraoperative and postoperative clinical courses were consistent with sclerolimbal ectasia. Adjunctive utilization of intraoperative low-dose 0.02% mitomycin C for the management of chronic uveitic glaucoma patients who are under concomitant systemic immunosuppressive regimen may enhance the risk of subacute postoperative sclerolimbal ectasia. Mitomycin C concentrations < 0.02%, decreased scleral exposure time, and a strict informed consent policy are strongly recommended in this subset of uveitic patients.
authors.affiliation: San Diego Children's Hospital, San Diego, CA 92123, USA. amirpirouzian@msn.com
authors.forename: A
authors.initials: A
authors.lastname: Pirouzian
authors.forename: H
authors.initials: H
authors.lastname: O'Halloran
authors.forename: C
authors.initials: C
authors.lastname: Scher
authors.forename: Y
authors.initials: Y
authors.lastname: Jockin
mesh_terms: D000293:Adolescent; D000477:Alkylating Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003316:Corneal Diseases / Q000139:chemically induced*; D004108:Dilatation, Pathologic / Q000139:chemically induced; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects*; D015422:Scleral Diseases / Q000139:chemically induced*; D014130:Trabeculectomy; D014606:Uveitis, Anterior / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin