Rat models of myocardial infarction. Pathogenetic insights and clinical relevance.
Animal models of cardiovascular pathology contribute towards understanding and treatment of a broad range of conditions. Specifically in the context of acute myocardial infarction (AMI), rat models have been commonly used in studies of pathogenesis, investigation and novel therapies, although there has often been difficulty in translating experimental findings to clinical benefit. However, recent years have seen two important changes to our clinical approaches to AMI. First, there is increasing recognition that the pathophysiology of human AMI is a process occurring at many levels, not just within the epicardial coronary artery, but also within the microvasculature and the myocardium. Second, contemporary treatments are shifting away from thrombolytic dissolution of epicardial coronary thrombus to direct mechanical approaches using angioplasty and stents. These changes in our understanding of AMI have implications for the relevance of these animal models. The following discussion therefore reviews and examines the current rat models of AMI, places them in a clinical context, discusses their advantages and limitations, and outlines likely future developments, providing an overview of the place of these important models of AMI.
Bhindi
Ravinay
R
Vascular Biology Laboratory, Anzac Research Institute, University of Sydney and Cardiology Department, Concord Repatriation General Hospital, New South Wales, Australia.
Witting
Paul K
PK
McMahon
Aisling C
AC
Khachigian
Levon M
LM
Lowe
Harry C
HC
D000818:Animals; D003328:Coronary Thrombosis / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000473:pathology; D051381:Rats