Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea.
Chemical exploration of Camchaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1 - 9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCI-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCI-H187 and BC cell lines, however the ester 10 showed only mild antimycobacterial activity.
Vongvanich
Namphung
N
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Kittakoop
Prasat
P
Charoenchai
Panarat
P
Intamas
Sutichai
S
Sriklung
Kanlayanee
K
Thebtaranonth
Yodhathai
Y
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D019659:Asteraceae; D045744:Cell Line, Tumor / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D010936:Plant Extracts