Association between plasma adiponectin levels and unstable coronary syndromes.
OBJECTIVE
Obesity is a risk factor for an acute coronary syndrome (ACS). The association between elevated body mass index (BMI) and ACS is independent of most traditional risk factors, suggesting a possible contribution of other body fat-related mediators. This study evaluated the association between adiponectin and ACS.


RESULTS
Four hundred and ninety-nine patients undergoing coronary angiography were divided into a subgroup without (n = 331) and with ACS (n = 168). In multiple regression analysis, higher adiponectin levels were independently associated with a lower risk of ACS [odds ratio (OR) = 0.61; 95% CIs: 0.46-0.81; P < 0.001]. In contrast, a higher BMI, a history of myocardial infarction, C-reactive protein, and angiographic coronary artery disease severity were all associated with a higher risk. The greatest increase in risk for ACS was seen at adiponectin levels < or = 5.5 microg/mL.


CONCLUSIONS
Higher plasma adiponectin levels are independently associated with a lower risk of ACS.
Wolk
Robert
R
Division of Cardiovascular Diseases, Mayo Clinic, 1216 Second Street SW, Rochester, MN 55902, USA. wolk.robert@mayo.edu
Berger
Peter
P
Lennon
Ryan J
RJ
Brilakis
Emmanouil S
ES
Davison
Diane E
DE
Somers
Virend K
VK
D054058:Acute Coronary Syndrome / Q000097:blood*; D052242:Adiponectin / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D011446:Prospective Studies; D012044:Regression Analysis
D052242:Adiponectin; D002097:C-Reactive Protein