Upper gastrointestinal tract eosinophilic disorders: pathobiology and management.
Patients with eosinophilic esophagitis present with symptoms similar to those from gastroesophageal reflux disease along with dense esophageal eosinophilia (normal gastric and duodenal biopsies) that persist despite aggressive acid blockade. The dramatic increase in prevalence of eosinophilic esophagitis over the past several years provides clinicians with a new explanation for previously unexplained dysphagia, food impaction, vomiting, and abdominal pain. As a product of this recognition, an increasing number of basic and translational studies are building a new understanding of the pathogenesis of esophageal eosinophilia. This review addresses recent studies that define clinical features, genetic predisposition, pathogenetic mechanisms, and treatment options for eosinophilic esophagitis.
Lee
Jessica J
JJ
Harvard Medical School, Children's Hospital Boston, 300 Longwood Avenue, Hunnewell Ground Floor, Boston, MA 02115, USA.
Furuta
Glenn T
GT
D001706:Biopsy; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal; D004802:Eosinophilia / Q000188:drug therapy* / Q000473:pathology*; D004941:Esophagitis / Q000188:drug therapy* / Q000473:pathology*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D016896:Treatment Outcome
D005765:Gastrointestinal Agents