Red blood cells and hemoglobin in hypoxic pulmonary vasoconstriction.
Nitric oxide (NO) plays an important role in the modulation of hypoxic pulmonary vasoconstriction; in turn, red blood cells (RBCs) augment HPV by hemoglobin-mediated oxidation and inactivation of NO. In addition, scavenging of reactive oxygen species by RBCs may play a role in augmentation of HPV. NO delivery and/or production by RBCs does not appear to be important in the control of pulmonary vasomotor tone. This review will discuss regulation of HPV by RBCs with an emphasis on hemoglobin-NO interactions. In addition, the review will discuss how biologic (S-nitrosation) or pharmacologic (cross-linking) modification of hemoglobin may affect pulmonary circulatory-hemoglobin interactions.
Deem
Steven
S
Department of Anesthesiology, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA. sdeem@u.washington.edu
D000818:Animals; D004912:Erythrocytes / Q000166:cytology*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia; D008168:Lung / Q000098:blood supply*; D009569:Nitric Oxide / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011652:Pulmonary Circulation; D011659:Pulmonary Gas Exchange; D012039:Regional Blood Flow; D014652:Vascular Diseases / Q000473:pathology; D014661:Vasoconstriction
D006454:Hemoglobins; D009569:Nitric Oxide; D010100:Oxygen