title: Aortic depressor nerve function examined in diabetic rats by means of two different approaches.
abstract: The present study examined in anesthetized rats, 5 or 120 days after the onset of streptozotocin-induced diabetes, the aortic depressor nerve (ADN) function by means of pressure-nerve activity curve (fitted by sigmoidal regression) and cross-spectral analysis between mean arterial pressure (MAP) and ADN activity. From the sigmoidal regression curve it was calculated the upper and lower ADN activity plateau, range, average gain and MAP halfway between the lower and upper plateau (MAP50). By means of spectral analysis it was calculated the transfer function magnitude (ratio of ADN activity/MAP) as an index of ADN sensitivity (gain) during induced (withdrawal and reinfusion of blood) slow (0.35 Hz) oscillations of MAP simulating Mayer's waves and spontaneous oscillations (approximately 1.5 Hz) caused by respiratory movement. Diabetic rats exhibited, at 5 or 120 days, lower MAP and heart rate. The parameters calculated by means of the sigmoidal regression curve, as well as the ADN activity gain during slow or spontaneous oscillations of MAP, were similar in diabetic and control rats. In conclusion, it was demonstrated that ADN activity was not altered after 5 or 120 days of experimental diabetes, even though the literature documents, at this time frame of diabetes, a conspicuous derangement of the baroreflex.
authors.affiliation: Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, Brazil.
authors.forename: Jussara M
authors.initials: JM
authors.lastname: do Carmo
authors.forename: Domitila A
authors.initials: DA
authors.lastname: Huber
authors.forename: Jaci A
authors.initials: JA
authors.lastname: Castania
authors.forename: Valéria P S
authors.initials: VP
authors.lastname: Fazan
authors.forename: Rubens
authors.initials: R
authors.lastname: Fazan
authors.forename: Helio C
authors.initials: HC
authors.lastname: Salgado
mesh_terms: D000818:Animals; D001011:Aorta / Q000294:innervation* / Q000503:physiopathology*; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013057:Spectrum Analysis; D013997:Time Factors