Coronary calcification in body builders using anabolic steroids.
The authors measured coronary artery calcification as a means of examining the impact of anabolic steroids on the development of atherosclerotic disease in body builders using anabolic steroids over an extended period of time. Fourteen male professional body builders with no history of cardiovascular disease were evaluated for coronary artery calcium, serum lipids, left ventricular function, and exercise-induced myocardial ischemia. Seven subjects had coronary artery calcium, with a much higher than expected mean score of 98. Six of the 7 calcium scores were >90th percentile. Mean total cholesterol was 192 mg/dL, while mean high-density lipoprotein was 23 mg/dL and the mean ratio of total cholesterol to high-density lipoprotein was 8.3. Left ventricular ejection fraction ranged between 49% and 68%, with a mean of 59%. No subject had evidence of myocardial ischemia. This small group of professional body builders with a long history of steroid abuse had high levels of coronary artery calcium for age. The authors conclude that in this small pilot study there is an association between early coronary artery calcium and long-term steroid abuse. Large-scale studies are warranted to further explore this association.
Santora
Lawrence J
LJ
Orange County Heart Institute and Research Center, Orange, CA 92668, USA. lsantora@cox.net
Marin
Jairo
J
Vangrow
Jack
J
Minegar
Craig
C
Robinson
Mary
M
Mora
Janet
J
Friede
Gerald
G
D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D002113:Calcification, Physiologic / Q000187:drug effects*; D002114:Calcinosis / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology; D002118:Calcium / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D015243:Cholesterol, VLDL / Q000097:blood / Q000187:drug effects; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology*; D004300:Doping in Sports; D025401:Echocardiography, Stress; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology; D010865:Pilot Projects; D012307:Risk Factors; D013177:Sports; D013256:Steroids / Q000009:adverse effects*; D013318:Stroke Volume / Q000187:drug effects; D014280:Triglycerides / Q000097:blood; D016277:Ventricular Function, Left / Q000187:drug effects
D045930:Anabolic Agents; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D013256:Steroids; D014280:Triglycerides; D002118:Calcium