Eosinophilic esophagitis: pathogenesis, genetics, and therapy.
Eosinophilic esophagitis (EE) is a recently recognized disorder characterized by the accumulation of eosinophils in the esophagus. Symptoms of EE frequently mimic those of gastroesophageal reflux disease, but the 2 diseases are quite distinct in terms of the histopathology and response to therapy. We demonstrate that EE involves the interplay of numerous genes, especially the eosinophil chemoattractant eotaxin-3, allowing molecular distinction from other forms of esophagitis and consideration of targeted therapeutic intervention.
Blanchard
Carine
C
Division of Allergy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Wang
Ning
N
Rothenberg
Marc E
ME
D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000628:therapy; D004941:Esophagitis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000628:therapy; D006801:Humans