[Predictive value of serum soluble fms-like tyrosine kinase 1 concentration in preeclampsia at second trimester].
OBJECTIVE
To explore the predictive value of serum soluble fms-like tyrosine kinase-1 (sFlt-1) and vascular endothelia growth factor (VEGF) levels in preeclampsia at second trimester.


METHODS
Serum sFlt-1, VEGF concentrations were determined in 172 initial normal pregnant women at 26 - 28 gestation week. The outcomes of pregnancies were followed. In a cohort of 172 pregnant women, 16 cases of preeclampsia were developed (preeclampsia group), and 156 cases were with no complication (control group).


RESULTS
The serum levels of sFlt-1 in preeclampsia group (11.4 +/- 6.2) microg/L were significantly higher than that in control group (4.5 +/- 2.1) microg/L (P < 0.01). The serum levels of sFlt-1 in precelampsia women with the onset before 32 gestation week and fetal growth retardation, (14.0 +/- 6.8) microg/L, (14.4 +/- 6.7) microg/L were significantly higher than that in women with the onset after 32 gestation week and with no fetal growth retardation (9.0 +/- 4.1) microg/L, (8.9 +/- 4.0) microg/L, respectively (P < 0.05). There was no significant difference in the serum levels of VEGF between preeclampsia group and control group. A sFlt-1 cutoff value of 8.75 microg/L at 26 - 28 gestation week yielded a sensitivity of 87.5%, specificity of 97.4%, positive predictive value of 80.0%, negative predictive value of 88.5%, respectively, for subsequent onset of preeclampsia.


CONCLUSIONS
Maternal serum sFlt-1 concentration at second trimester can be used as an early predictive marker of preeclampsia.
Ye
Yuan-hua
YH
Department of Obstetrics and Gynecology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China.
Liu
Ling
L
Zhan
Ying
Y
Peng
Wei
W
D000328:Adult; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1