The mitotic spindle matrix: a fibro-membranous lamin connection.
The mitotic spindle apparatus has attracted the attention of cell biologists for decades. Whereas the main function of this microtubule-based system is to segregate chromosomes, spindle morphogenesis and chromosome segregation must also coordinate with the segregation of the whole cell. The finding that RanGTPase stimulates the assembly of a lamin B-containing membranous matrix in mitosis(1) may provide a connection between the segregation of mitotic chromosomes and the partitioning of membrane systems during cell division.
Zheng
Yixian
Y
Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, Maryland 21218, USA. zheng@ciwemb.edu
Tsai
Ming-Ying
MY
D020090:Chromosome Segregation; D006801:Humans; D007399:Interphase; D007797:Laminin / Q000378:metabolism*; D008938:Mitosis; D008941:Spindle Apparatus / Q000378:metabolism* / Q000502:physiology; D020931:ran GTP-Binding Protein / Q000502:physiology
D007797:Laminin; D020931:ran GTP-Binding Protein