Usefulness of the immunological rapid urease test for detection of Helicobacter pylori in patients who are reluctant to undergo endoscopic biopsies.
Cardiovascular diseases and liver cirrhosis are in the list of Helicobacter pylori-related extragastric diseases. Patients with cirrhosis and cardiovascular diseases under the control of aspirin have increased risk of gastrointestinal bleeding. The immunological rapid urease test (IRUT) provides a rapid and safe diagnostic test for H. pylori using gastric mucus collected at endoscopy. We investigated its usefulness in 93 patients with these extragastric diseases including 46 with H. pylori infection assessed by urea breath test and serology. Twenty H. pylori-infected patients received eradication therapy and the IRUT was assessed to evaluate the efficacy of bacterial eradication. The sensitivity, specificity, and positive and negative predictive values for IRUT were 96%, 90%, 90%, and 96%, respectively. The results of IRUT completely agreed with those of urea breath test following anti-H. pylori therapy. The IRUT has acceptable diagnostic performance in such cohorts reluctant to undergo endoscopic biopsies due to the risk of bleeding.
Isomoto
Hajime
H
Department of Endoscopy, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. hajimei2002@yahoo.co.jp
Kawazoe
Kaoru
K
Inoue
Kenichiro
K
Kohno
Shigeru
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis; D001706:Biopsy / Q000009:adverse effects; D003955:Diagnostic Tests, Routine / Q000379:methods*; D016099:Endoscopy, Gastrointestinal / Q000009:adverse effects; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000201:enzymology / Q000276:immunology*; D016480:Helicobacter pylori / Q000201:enzymology* / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014510:Urease / Q000276:immunology* / Q000378:metabolism
D000907:Antibodies, Bacterial; D014510:Urease