title: Minimally invasive parathyroidectomy without intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism.
abstract: BACKGROUND
  Minimally invasive parathyroidectomy (MIP) is the preferred operation for patients with primary hyperparathyroidism (HPT) and positive preoperative imaging. This non-randomized case series assessed the long-term results of MIP performed without the use of intraoperative parathyroid hormone (ioPTH) monitoring.
  
  
  METHODS
  The study involved prospective collection of demographic, biochemical and operative details on a consecutive, unselected cohort of 298 patients who underwent surgery for non-familial primary HPT during a 5-year interval. The mean preoperative serum calcium level was 3.00 mmol/l with a mean parathyroid hormone concentration of 25.8 pmol/l. (99m)Tc-labelled sestamibi scanning and neck ultrasonography were performed in 262 patients.
  
  
  RESULTS
  Sestamibi scan showed unilateral uptake in 182 patients and a single parathyroid adenoma was confirmed on ultrasonography in 161 patients. MIP was performed in 150 patients. The mean duration of operation was 25 (range 8-65) min. Four patients needed conversion to conventional neck exploration. There was one postoperative haematoma and three cases of temporary recurrent laryngeal nerve neuropraxia. All but four patients were normocalcaemic after MIP. All the parathyroid tumours removed were adenomas, with a mean weight of 1.3 (range 0.1-17.4) g. No patient developed recurrent HPT after a median follow-up of 16 (range 3-48) months.
  
  
  CONCLUSIONS
  The outcome of MIP without ioPTH monitoring was comparable to that reported in series that used ioPTH monitoring.
authors.affiliation: Department of Endocrine Surgery, John Radcliffe Hospital, Oxford, UK.
authors.forename: R
authors.initials: R
authors.lastname: Mihai
authors.forename: F F
authors.initials: FF
authors.lastname: Palazzo
authors.forename: F V
authors.initials: FV
authors.lastname: Gleeson
authors.forename: G P
authors.initials: GP
authors.lastname: Sadler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010281:Parathyroid Hormone / Q000097:blood*; D016105:Parathyroidectomy / Q000379:methods*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: C470125:PTH protein, human; D010281:Parathyroid Hormone; D002118:Calcium