title: Dopamine and adult neurogenesis.
abstract: Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we approach a highly controversial question: can the adult human brain use neurogenesis to replace the dopaminergic neurones in the substantia nigra that are lost in Parkinson's disease?
authors.affiliation: Experimental Neurology, Philipps University, Marburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Borta
authors.forename: Günter U
authors.initials: GU
authors.lastname: Höglinger
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D013234:Stem Cells / Q000378:metabolism*; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism / Q000503:physiopathology
chemical_list: D004298:Dopamine