Lipases in beta-dipeptide synthesis in organic solvents.
A number of beta-dipeptides were prepared by two-step lipase-catalyzed reactions where N-acetylated beta-amino esters were first activated as 2,2,2-trifluoroethyl esters with Candida antarctica lipase B (CAL-B). The activated esters were then used to acylate beta-amino ester in the presence of Candida antarctica lipase A (CAL-A) in dry Et2O or i-Pr2O. [reaction: see text].
Li
Xiang-Guo
XG
Department of Pharmacology, Drug Development and Therapeutics/Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, Lemminkaisenkatu 5C, FIN- 20520 Turku, Finland.
Kanerva
Liisa T
LT
D000107:Acetylation; D000215:Acylation; D000596:Amino Acids / Q000737:chemistry; D002175:Candida / Q000201:enzymology; D004151:Dipeptides / Q000138:chemical synthesis*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D008049:Lipase / Q000737:chemistry*; D008968:Molecular Conformation; D012997:Solvents; D013237:Stereoisomerism
D000596:Amino Acids; D004151:Dipeptides; D004952:Esters; D012997:Solvents; D008049:Lipase