Progress towards the clinical application of helper-dependent adenoviral vectors for liver and lung gene therapy.
This review focuses on recent developments in helper-dependent adenoviral technology and preclinical studies for helper-dependent adenovirus-mediated liver- and lung-directed gene therapy. Studies highlighting the tremendous potential of these vectors are reviewed, together with some important obstacles that will need to be addressed before clinical utility.
Brunetti-Pierri
Nicola
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Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza T619, Houston, TX 77030, USA.
Ng
Philip
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D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D018014:Gene Transfer Techniques / Q000639:trends; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics*; D006378:Helper Viruses / Q000235:genetics*; D006801:Humans; D008107:Liver Diseases / Q000628:therapy*; D008171:Lung Diseases / Q000628:therapy*