Expression of viral microRNAs in Epstein-Barr virus-associated gastric carcinoma.
Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.
Kim
Do Nyun
DN
Research Institute of Immunobiology, Catholic University of Korea, Seoul, Korea.
Chae
Hiun-Suk
HS
Oh
Sang Taek
ST
Kang
Jin-Hyoung
JH
Park
Cho Hyun
CH
Park
Won Sang
WS
Takada
Kenzo
K
Lee
Jae Myun
JM
Lee
Won-Keun
WK
Lee
Suk Kyeong
SK
D000818:Animals; D045744:Cell Line, Tumor; D005260:Female; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
C083278:BHRF1 protein, Human herpesvirus 4; D035683:MicroRNAs; D014764:Viral Proteins