Aerosolization potential of cyclodextrins--influence of the operating conditions.
The aim of this work is to characterize the aerosols obtained by jet nebulization with cyclodextrin solutions and to study the influence of operating conditions on nebulization efficiency. Two cyclodextrins, an hydroxypropyl cyclodextrin (Kleptose HP) and a polydisperse methyl beta cyclodextrin (Crysmeb), were tested with 14 nebulizers that differ geometrically. We first determined the physicochemical properties of density, viscosity, and surface tension for the cyclodextrin solutions. Nebulization efficiency was evaluated by measuring droplet size, nebulization rate, quantity of solution nebulized, and nebulization time. We studied the influence of the technological parameters of pressure and nebulizer type and the influence of the formulation on performance efficiency. The use of different nebulizers and different pressure conditions results in variable efficiency. Regardless of the type of nebulizer, an increase in pressure decreases droplet size and increases nebulization rate. The influence of the nebulizer design is considerable. The aqueous cyclodextrin solutions studied can generate aerosols in particle size ranges suitable for pulmonary deposition. Large quantities of aerosol can be nebulized in acceptable nebulization times. The cyclodextrin concentration does not modify nebulization efficiency in the range tested.
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Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacotechnie Industrielle, rue du Professeur Laguesse, BP 83, 59006 LILLE, France.
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D000336:Aerosols; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins / Q000737:chemistry*; D005079:Excipients; D009330:Nebulizers and Vaporizers; D019999:Pharmaceutical Solutions; D013500:Surface Tension; D014465:Ultrasonics; D014783:Viscosity
D000336:Aerosols; D003505:Cyclodextrins; D005079:Excipients; D019999:Pharmaceutical Solutions