Pathophysiology and medical management of systemic hypertension in preeclampsia.
Hypertension that complicates preeclampsia in pregnancy is a disorder that requires special consideration in both prevention and pharmacologic treatment. In recent years, few advances have been made regarding the pathophysiology and prevention of preeclampsia; however, there have been some promising results from studies on possible modes of screening women for preeclampsia before clinical signs and symptoms are apparent. The recommendations for first-line drug therapy for the hypertensive complications of preeclampsia have changed little, primarily because first-line medications have had the advantage of extensive research experience. Recent clinical trials have demonstrated the efficacy and safety of various second-line drugs for the hypertensive complications of preeclampsia; whether these therapies can eventually replace the standard recommended first-line medications will require more extensive long-term investigation.
Frishman
William H
WH
Department of Medicine, New York Medical College, Valhalla, NY 10595, USA. william_frishman@nymc.edu
Veresh
Megan
M
Schlocker
Stacy J
SJ
Tejani
Nergesh
N
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000209:etiology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D007511:Ischemia / Q000503:physiopathology; D007741:Labetalol / Q000627:therapeutic use; D008099:Liver / Q000502:physiology; D009529:Nicardipine / Q000627:therapeutic use; D009543:Nifedipine / Q000627:therapeutic use; D010920:Placenta / Q000098:blood supply; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology; D020521:Stroke / Q000209:etiology
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins; D009529:Nicardipine; D009543:Nifedipine; D001241:Aspirin; D007741:Labetalol; D002118:Calcium