title: Pregabalin (Lyrica) in the treatment of essential tremor.
abstract: We report on 2 essential tremor patients who experienced marked improvement in upper extremity tremor with the use of pregabalin (Lyrica, PGB). On PGB 200 mg/day, tremor amplitude was reduced by at least 40% in the worst affected hand in both patients as measured by accelerometry. Both patients also reported moderate reduction in tremor on the Clinical Global Impression Scale, and Fahn-Tolosa-Marin Part I scores were markedly improved.
authors.affiliation: Parkinson's Disease and Movement Disorders Center, Department of Neurology, Neuroscience Program, University of South Florida, Tampa, Florida 33612, USA. tzesiewi@hsc.usf.edu
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Zesiewicz
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Ward
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hauser
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Pease Campbell
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Sullivan
mesh_terms: D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D020329:Essential Tremor / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069583:Pregabalin; D011597:Psychomotor Performance / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid