[Preparation of puerarin solid self-microemulsion].
OBJECTIVE
To prepare puerarin solid self-microemulsifying drug delivery system (SMEDDS).


METHODS
Pseudo-ternary phase diagram was used to select the formula of microemulsion. The self-microemulsification efficiency was assessed, such as viscosity, conductance, refraction, zeta potential, size ditribution, dissolution were investigated. Puerarin were determined by UV to calculate the cumulative release at different time.


RESULTS
The optimum formulation of puerarin solid self-microemulsifying drug delivery system the consisted of puerarin-Tween 800 glycerinum-ethyl oleate-water-Gum Acacia-manicol at weight ratio of 1.7: 16. 6: 16. 6: 16. 6 : 1.3: 4.0: 39.9: 19.9; Average particle diameter was 30 nm; The dissolution was 94.29% at 10 min.


CONCLUSIONS
Stability of puerarin solid self-microemulsion drug delvery system is good, potent in improving the dissolution of puerarin.
Yu
Ai-Hua
AH
College of Pharmacy, Shandong University, Jinan 250012, China. yuaihua@sdu.edu.cn
Zhai
Guang-Xi
GX
Cui
Jing
J
Liu
Hong
H
D001682:Biological Availability; D016503:Drug Delivery Systems / Q000379:methods; D004355:Drug Stability; D004655:Emulsions; D007529:Isoflavones / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water
D004655:Emulsions; D007529:Isoflavones; D013501:Surface-Active Agents; D014867:Water; C033607:puerarin