Parallel solution-phase synthesis of acrylonitrile scaffolds carrying L-alpha-amino acidic or D-glycosyl residues.
A practical and straightforward protocol for the preparation of a solution-phase library of acrylonitrile scaffolds is reported. Target compounds were obtained in high yield, stereoselectivity, and purity by two simple and practical steps from cyanoacetic acid. Moreover, our study proposes a synthetic approach starting from the constructed library to obtain three-membered heterocycles.
Fioravanti
Stefania
S
Dipartimento di Chimica, Università degli Studi La Sapienza, P.le Aldo Moro 2, I-00185 Roma, Italy.
Pellacani
Lucio
L
Tardella
Paolo A
PA
Morreale
Alberto
A
Del Signore
Giuseppe
G
D000085:Acetates / Q000737:chemistry; D000181:Acrylonitrile / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism
D000085:Acetates; D000596:Amino Acids; D012996:Solutions; D000181:Acrylonitrile; C007170:cyanoacetic acid