Biosynthesis of streptolydigin: origin of the oxygen atoms.
[Structure: see text] Biosynthetic incorporations of [13C,18O]-labeled precursors into streptolydigin reveal the origin of the oxygen atoms, limiting the possible pathways for acyltetramic acid ring assembly and for formation of the bicyclic ketal.
Chen
Hao
H
Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4M1, Canada.
Olesen
Solveig G
SG
Harrison
Paul H M
PH
D000617:Aminoglycosides / Q000096:biosynthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism*; D010103:Oxygen Isotopes; D013302:Streptomyces / Q000378:metabolism*
D000617:Aminoglycosides; D010103:Oxygen Isotopes; C100307:streptolydigin; D010100:Oxygen