[Immunogenetic analysis of variants of a clinical course and prognosis of chronic glomerulonephritis in the west Siberia].
OBJECTIVE
To analyze association of HLA antigens with clinical variants of chronic glomerulonephritis (CGN)in 106 patients.


METHODS
HLA association with the time of development of terminal chronic renal failure (CRF) from the moment of detection of initial CRF was studied in 80 patients. Determination of HLA of class I was conducted in the lymphocytotoxic test. DRB1 genes specificity was determined with DNA polymerase chain reaction. The control group consisted of 341 healthy citizens of Novosibirsk. Common HLA associations of latent and hypertensive, latent and nephrotic CGN variants were found demonstrating their succession. HLA associations with a mixed CGN variant defining its genetic isolation were established. It is shown that development of terminal CRF at different time since the disease onset is associated with different HLA alleles. The findings allow prognosis of clinical CGN variants, time of development of terminal CRF.
Korotkova
I Iu
IIu
Valentik
M F
MF
Movchan
E A
EA
Maksimov
V S
VS
Ivanova
G G
GG
Konenkov
V I
VI
D000328:Adult; D002908:Chronic Disease; D004247:DNA / Q000235:genetics; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D015995:Prevalence; D016601:RNA-Binding Proteins / Q000235:genetics; D012800:Siberia / Q000453:epidemiology
D006680:HLA Antigens; D009419:Nerve Tissue Proteins; C467044:RBM45 protein, human; D016601:RNA-Binding Proteins; D004247:DNA