Successful unrelated bone marrow transplantation in a child with chronic granulomatous disease complicated by pulmonary and cerebral granuloma formation.
We report on a 6-year-old boy with chronic granulomatous disease (CGD) complicated by chronic inflammatory reactions with formation of large pulmonary granuloma as well as intracerebral lesions. Bone marrow transplantation (BMT) from an unrelated donor led to stable reconstitution, to rapid resolution of pulmonary granuloma, and to rapid resolution of intracerebral lesions.
Schuetz
Catharina
C
Department of Pediatrics, University of Ulm, Eythstrasse 24, 89073 Ulm, Germany.
Hoenig
Manfred
M
Schulz
Ansgar
A
Lee-Kirsch
Min Ae
MA
Roesler
Joachim
J
Friedrich
Wilhelm
W
von Bernuth
Horst
H
D016026:Bone Marrow Transplantation; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D054022:Cerebrum / Q000473:pathology; D002648:Child; D017353:Gene Deletion; D005819:Genetic Markers; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed
D005819:Genetic Markers