Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate.
A spectroscopic assay based on surface enhanced Raman scattering (SERS) using silver nanorod array substrates has been developed that allows for rapid detection of trace levels of viruses with a high degree of sensitivity and specificity. This novel SERS assay can detect spectral differences between viruses, viral strains, and viruses with gene deletions in biological media. The method provides rapid diagnostics for detection and characterization of viruses generating reproducible spectra without viral manipulation.
Shanmukh
Saratchandra
S
Department of Chemistry, Physics and Astronomy and Center for Disease Intervention, Department of Infectious Diseases, University of Georgia, Athens, Georgia 30602, USA.
Jones
Les
L
Driskell
Jeremy
J
Zhao
Yiping
Y
Dluhy
Richard
R
Tripp
Ralph A
RA
D017353:Gene Deletion; D006801:Humans; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry*; D012015:Reference Standards; D018113:Respiratory Syncytial Virus, Human / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods* / Q000592:standards; D013499:Surface Properties
D012834:Silver