Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
Three new alkaloids (1-3) and twenty-one known compounds were isolated from the stem of Fissistigma oldhamii (Hemsl.) Merr. which was the ruler herb in an approved Traditional Chinese herbal formula used for treatment of rheumatoid arthritis in China and synthesis of one new immunosuppressive alkaloid was achieved. These compounds, including the crude extracts of this herb, exhibited strong activities in the inhibition of T and B cell proliferation.
Zhang
Yi-Nan
YN
Shanghai Research Center for Modernization of Traditional Chinese Medicine and First Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
Zhong
Xiang-Gen
XG
Zheng
Zong-Ping
ZP
Hu
Xu-Dong
XD
Zuo
Jian-Ping
JP
Hu
Li-Hong
LH
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D016572:Cyclosporine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004121:Dimethyl Sulfoxide; D015195:Drug Design; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis; D018547:Plant Stems / Q000737:chemistry; D012996:Solutions; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D007166:Immunosuppressive Agents; D010936:Plant Extracts; D012996:Solutions; D012997:Solvents; D016572:Cyclosporine; D004121:Dimethyl Sulfoxide