Particulate systems as adjuvants and carriers for peptide and protein antigens.
The most common feature for antigen-delivery systems is their particulate nature. Together with a certain depot effect, it is the particulate nature that primarily dictates whether the antigen-delivery system will be successful in inducing a certain type and strength of immune response. In this article, we will summarize recent data on particulate delivery systems for peptide and protein antigens with a main focus on lipid or polymer-based particles, all of which possess high potential as both preventive and therapeutic vaccines for parenteral, nasal, and possibly oral administration.
Liang
Ming Tao
MT
School of Pharmacy, University of Queensland, Australia.
Davies
Nigel M
NM
Blanchfield
Joanne T
JT
Toth
Istvan
I
D000277:Adjuvants, Pharmaceutic / Q000737:chemistry*; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D016882:ISCOMs; D008081:Liposomes; D010316:Particle Size; D010455:Peptides / Q000008:administration & dosage*; D014614:Vaccines, Synthetic / Q000008:administration & dosage*
D000277:Adjuvants, Pharmaceutic; D000941:Antigens; D004337:Drug Carriers; D016882:ISCOMs; D008081:Liposomes; D010455:Peptides; D014614:Vaccines, Synthetic