title: Gene Aging Nexus: a web database and data mining platform for microarray data on aging.
abstract: The recent development of microarray technology provided unprecedented opportunities to understand the genetic basis of aging. So far, many microarray studies have addressed aging-related expression patterns in multiple organisms and under different conditions. The number of relevant studies continues to increase rapidly. However, efficient exploitation of these vast data is frustrated by the lack of an integrated data mining platform or other unifying bioinformatic resource to enable convenient cross-laboratory searches of array signals. To facilitate the integrative analysis of microarray data on aging, we developed a web database and analysis platform 'Gene Aging Nexus' (GAN) that is freely accessible to the research community to query/analyze/visualize cross-platform and cross-species microarray data on aging. By providing the possibility of integrative microarray analysis, GAN should be useful in building the systems-biology understanding of aging. GAN is accessible at http://gan.usc.edu.
authors.affiliation: Department of Biological Sciences, University of Southern California Los Angeles, CA 90089, USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Pan
authors.forename: Chi-Hsien
authors.initials: CH
authors.lastname: Chiu
authors.forename: Sudip
authors.initials: S
authors.lastname: Pulapura
authors.forename: Michael R
authors.initials: MR
authors.lastname: Mehan
authors.forename: Juan
authors.initials: J
authors.lastname: Nunez-Iglesias
authors.forename: Kangyu
authors.initials: K
authors.lastname: Zhang
authors.forename: Kiran
authors.initials: K
authors.lastname: Kamath
authors.forename: Michael S
authors.initials: MS
authors.lastname: Waterman
authors.forename: Caleb E
authors.initials: CE
authors.lastname: Finch
authors.forename: Xianghong Jasmine
authors.initials: XJ
authors.lastname: Zhou
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D006801:Humans; D020407:Internet; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D012984:Software; D014584:User-Computer Interface