title: Inter-rater reliability of manual segmentation of the superior, inferior and middle frontal gyri.
abstract: Precise rules for locating the anatomical boundaries of the dorsolateral prefrontal cortex (DLPFC) or its subdivisions, i.e., superior, inferior and middle frontal gyri (SFG, IFG and MFG) on magnetic resonance images (MRI), have not been defined. The present study describes the inter-rater reliability of manual segmentation of the SFG, IFG and MFG using guidelines based on sulcal-gyral anatomical boundaries as well as the cytoarchitectonic features of the sub-regions of the prefrontal cortex (PFC). Variations in the application of these guidelines in different subjects to account for normal sulcal variability were developed using the atlas of Ono et al. (Ono, M., Kubik, S., Abernathey, C.D., 1990. Atlas of the Cerebral Sulci. Georg Thieme Verlag, New York). Based on previous cytoarchitectonic studies, the coronal plane of the anterior termination of olfactory sulcus (ATOS) was used as a landmark for delimiting the boundary between the frontal pole (FP) and the frontal gyri. The left hemisphere gray-matter volumes of the SFG, IFG and MFG were determined using a set of 10 MRIs (5 normal and 5 schizophrenia subjects) by two trained raters independently. The intra-class correlation coefficients (ICC) for the SFG, IFG and MFG volumes by the two raters were 0.97, 0.94 and 0.93, respectively. Thus, we describe a reliable method of parcellating the SFG, IFG and MFG, which constitute the DLPFC, a brain region involved in a variety of neuropsychiatric conditions.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore 560 029, Karnataka, India. jpj@nimhans.kar.nic.in
authors.forename: John P
authors.initials: JP
authors.lastname: John
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Moffitt
authors.forename: Harmeeta K
authors.initials: HK
authors.lastname: Singh
authors.forename: Mokhtar H
authors.initials: MH
authors.lastname: Gado
authors.forename: John G
authors.initials: JG
authors.lastname: Csernansky
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002552:Cerebral Ventricles / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology; D004292:Dominance, Cerebral / Q000502:physiology; D005625:Frontal Lobe / Q000473:pathology*; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data*; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D015588:Observer Variation; D017397:Prefrontal Cortex / Q000473:pathology*; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis*