Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens.
Two new xanthones, 1,3,8-trihydroxy-2,4-dimethoxyxanthone (1) and 1,7-dihydroxy-2,8-dimethoxyxanthone (2), along with twelve known compounds 3 - 14 were isolated from leaves and twigs of Cratoxylum arborescens. Compound 1, euxanthone (4), betulinic acid (8), lup-20(29)-ene-3beta,30-diol (9), 3beta-hydroxylup-20(29)-en-30-oic acid (10) and 3,4-dihydroxybenzoic acid (11) displayed anti-HIV-1 activities in the syncytium assay using (Delta)(Tat/Rev)MC99 virus and the 1A2 cell line system (EC (50) values between 3.9 and 32.2 microg/mL with TI ranging from 1.5 to 11.7), while 1,3,7-trihydroxy-6-methoxy-4,5-diisoprenylxanthone (3), 4, and 8 - 10 inhibited HIV-1 reverse transcriptase with IC (50) values between 8.7 and 84.9 microg/mL.
Reutrakul
Vichai
V
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand. scvrt@mahidol.ac.th
Chanakul
Waraporn
W
Pohmakotr
Manat
M
Jaipetch
Thaworn
T
Yoosook
Chalobon
C
Kasisit
Jittra
J
Napaswat
Chanita
C
Santisuk
Thawatchai
T
Prabpai
Samran
S
Kongsaeree
Palangpon
P
Tuchinda
Patoomratana
P
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D028084:Clusiaceae; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D010936:Plant Extracts