title: Effects of fasting and refeeding on expression of atrogin-1 and Akt/FOXO signaling pathway in skeletal muscle of chicks.
abstract: This experiment was conducted to study the effects of fasting and refeeding on expression of the atrogin-1 and Akt/FOXO signaling pathway in skeletal muscle of chicks. Chicks were fasted for 24 h and refed for 2 h. Atrogin-1 mRNA expression was increased by fasting, and their increment was reduced by refeeding. Phosphorylations of Akt and FOXO1 were not decreased by fasting, but, they were increased by refeeding. These results indicate that refeeding stimulates phosphorylation of Akt/FOXO, resulting in a decrease in atrogin-1 expression in skeletal muscle of chicks.
authors.affiliation: Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland Science, Tsukuba, Japan. kaznaka@affrc.go.jp
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nakashima
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yakabe
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Abe
mesh_terms: D000821:Animal Feed; D000818:Animals; D002645:Chickens; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D044843:SKP Cullin F-Box Protein Ligases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051858:Forkhead Transcription Factors; D009124:Muscle Proteins; D012333:RNA, Messenger; D044843:SKP Cullin F-Box Protein Ligases; D051057:Proto-Oncogene Proteins c-akt