Antiretroviral therapy in HIV.
The advent of highly active antiretroviral therapy (HAART) has led to a significant decline in HIV-associated morbidity and mortality. Despite these recent advances, the majority of patients with HIV/AIDS worldwide are still lacking access to treatment. To date, there are 21 approved antiretrovirals divided into four categories based on their mechanism of action. We review the basic characteristics of these antiretrovirals. We also briefly discuss current guidelines regarding the use of antiretrovirals in general as well as in special populations such as in pregnant women, in occupational exposure and non occupational exposure.
Yu
Aimee
A
Mayo Clinic College of Medicine, Rochester, MN, USA.
Berbari
Elie
E
Temesgen
Zelalem
Z
D000328:Adult; D044966:Anti-Retroviral Agents / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000592:standards*; D014943:Global Health; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology; D006297:Health Services Accessibility; D006801:Humans; D017410:Practice Guidelines as Topic; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use
D044966:Anti-Retroviral Agents; D011480:Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors