[Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus].
Single injection of Bacillus intermedius RNAase in a dose of 5 mg/kg could protect 40 and 50-70% of the outdoor rabies virus-preinfected guinea-pigs and rabbits, respectively. In the control group there were 100 and 75-100% deaths of the RNAase-untreated guinea-pigs and rabbits, respectively. Animal protection was observed only when RNAase was injected into the site of viral administration. The intramuscular injection of RNAase, other than the site of viral administration failed to protect the infected animals. The efficacy (75%) of RNAase injected into the rabbits was similar 1 and 24 hours after animal infection.
Gribencha
S V
SV
Potselueva
L A
LA
Barinskiĭ
I F
IF
Deev
S M
SM
Balandin
T G
TG
Leshchinskaia
I B
IB
D000818:Animals; D001407:Bacillus / Q000201:enzymology*; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D011817:Rabbits; D011818:Rabies / Q000188:drug therapy* / Q000517:prevention & control; D011820:Rabies virus / Q000187:drug effects; D012260:Ribonucleases / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D001426:Bacterial Proteins; D012260:Ribonucleases