Directional signals in the prefrontal cortex and in area MT during a working memory for visual motion task.
Neurons in the middle temporal visual area (MT) have been implicated in the perception of visual motion, whereas prefrontal cortex (PFC) neurons have been linked to temporary storage of sensory signals, attentional and executive control of behavior. Using a task that placed demands on both sets of neurons, we investigated their contribution to working memory for visual motion. Monkeys compared the direction of two moving random-dot stimuli, sample and test, separated by a brief memory delay. Neurons in both areas showed robust direction-selective activity during all phases of the task. During the sample, approximately 60% of task-related PFC neurons were direction selective, and this selectivity emerged 40 ms later than in MT. Unlike MT, the PFC responses to sample did not correlate with behavioral choices, but their selectivity was modulated by task demands and diminished on error trials. Reliable directional signals were found in both areas during the memory delay, but these signals were transient rather than sustained by neurons of either area. Responses to the test in both areas were modulated by the remembered sample direction, decreasing when the test direction matched the sample. This decrease arose in the PFC 100 ms later than in MT and was predictive of the forthcoming decision. Our data suggest that neurons in the two regions are functionally connected and make unique contributions to different task components. PFC neurons reflect task-related information about visual motion and represent decisions that may be based, in part, on the comparison in MT between the remembered sample and test.
Zaksas
Daniel
D
Department of Neurobiology and Anatomy, Department of Brain and Cognitive Science, and Center for Visual Science, University of Rochester, Rochester, New York 14642, USA.
Pasternak
Tatiana
T
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D001931:Brain Mapping; D002755:Choice Behavior / Q000502:physiology; D003463:Cues; D004192:Discrimination, Psychological / Q000502:physiology*; D008253:Macaca mulatta; D008254:Macaca nemestrina; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009039:Motion Perception / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D012372:ROC Curve; D011930:Reaction Time / Q000502:physiology; D013702:Temporal Lobe / Q000166:cytology / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology