Alpha-bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin.
Steam distilled essential oil from the aerial parts of Pogostemon cablin was analyzed by gas chromatography-mass spectrometry (GC-MS). Forty one compounds were identified of which alpha-guaiene (20.62%) and alpha-bulnesene (16.18%) were major constituents. Furthermore, fractionation of the essential oil from P. cablin guided by inhibitory activity against PAF-induced platelet aggregation led to the isolation of the sesquiterpene, alpha-bulnesene.
Tsai
Ying-Chieh
YC
Institute of Biochemistry and Molecular Biology National Yang-Ming University, Taipei, Taiwan. tsaiyc@ym.edu.tw
Hsu
Hui-Chun
HC
Yang
Wen-Chia
WC
Tsai
Wei-Jern
WJ
Chen
Chien-Chih
CC
Watanabe
Takashi
T
D000818:Animals; D019686:Lamiaceae; D008297:Male; D013058:Mass Spectrometry; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045789:Sesquiterpenes, Guaiane
D010938:Plant Oils; D010975:Platelet Aggregation Inhibitors; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C512113:alpha-bulnesene