title: Compatibility of electrolytically produced sodium hypochlorite solutions on long- term implanted dialysis catheters.
abstract: More than 20% of the world's population use a catheter for dialysis, despite guidelines limiting their use. Although the structure and design of the catheters differ by manufacturer, the material used in central venous catheters and peritoneal dialysis catheters are the same across manufacturers. Given the long-term use of these catheters in the dialysis population, the good compatibility of the antiseptics and disinfectants used on the catheters is imperative to prevent failure and cracking of the catheter material. Tensile strengths of commercially available catheters were measured after exposure to commonly used disinfectants. The tensile strength was then compared between the catheters by analyzing the displacement vs. force (N) curves produced during the evaluation. A total of 44 catheter lumens were evaluated. The electrolytically produced sodium hypochlorite solution, Alcavis 50/ExSept Plus, was the only solution shown to be compatible with all three catheter materials resulting in a deviation of less than 10% for each of the different catheter types. Electrolytically produced sodium hypochlorite solutions were the only solutions in this study that did not alter the physical properties of any of the catheters after long-term exposure.
authors.affiliation: Vice President, Research and Development, Alcavis International, Inc., Gaithersburg, Md., USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Mishkin
mesh_terms: D002408:Catheters, Indwelling; D004202:Disinfectants / Q000138:chemical synthesis / Q000494:pharmacology*; D004572:Electrolysis; D004866:Equipment Contamination / Q000517:prevention & control; D004867:Equipment Design; D006801:Humans; D008422:Materials Testing / Q000295:instrumentation / Q000379:methods; D010530:Peritoneal Dialysis / Q000295:instrumentation*; D006435:Renal Dialysis / Q000295:instrumentation*; D012973:Sodium Hypochlorite / Q000138:chemical synthesis / Q000494:pharmacology*; D013718:Tensile Strength
chemical_list: D004202:Disinfectants; D012973:Sodium Hypochlorite