Kinetic resolution of racemic secondary alcohols catalyzed by chiral diaminodiphosphine-Ir(I) complexes.
Chiral diaminodiphosphine-Ir(I) complexes were found to efficiently catalyze enantioselective oxidation of racemic secondary alcohols in acetone. In the presence of base, oxidative kinetic resolution of the alcohols proceeded smoothly with excellent enantioselectivity (up to 98% ee) under mild conditions. [reaction: see text].
Li
Yan-Yun
YY
State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, Peoples Republic of China.
Zhang
Xue-Qin
XQ
Dong
Zhen-Rong
ZR
Shen
Wei-Yi
WY
Chen
Gui
G
Gao
Jing-Xing
JX
D000096:Acetone / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D007700:Kinetics; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000438:Alcohols; D007659:Ketones; D009942:Organometallic Compounds; D000096:Acetone; D007495:Iridium