[Regulon in the treatment of hyperandrogenism in teenage girls].
The aim of study was to assess the efficiency of the use of combined oral contraceptive with dezogestrel-regulon in the treatment of hyperandrogenism in teenage girls. 14-18 y.o. girls with signs of hyperandrogenism have been investigated. Investigation included: physical examination, assessment of body mass, hirsute number, ultrasonography, FSH, LH, prolactin, testosterone, 17 OH progesterone in blood.


RESULTS
All the patients received Regulon from the 5th up to 21st day of menstrual cycle during 6 months. After the 6 months of treatment the regulation of menstrual cycle have been registered in 91% of patients. Reduction of hirsute number (from 24.1+/-1.0 to 11.0+/-1.2 ), ovarian volume by ultrasound (from 16.7+/-3.0 sm(3) to 7.1+/-0.9 sm(3)), level of LH (from 12.7+/-2.4 to 8.0+/-1.2 IU/L) and testosterone (from 4.2 +/-0.2 to 2.8+/-0.6 nmol/l) were registered. Regulon is effective for the treatment of hyperandrogenism in teenage girls.
Mkrtchian
M Ia
MIa
Arustamian
K K
KK
Totoian
E S
ES
Mirzoian
A S
AS
Simonian
D A
DA
D000293:Adolescent; D003280:Contraceptives, Oral, Synthetic / Q000627:therapeutic use*; D017135:Desogestrel / Q000627:therapeutic use*; D005260:Female; D006628:Hirsutism / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology
D003280:Contraceptives, Oral, Synthetic; D017135:Desogestrel