title: [Diagnosis and treatment of thyroid cancer in children in the multicenter analysis in Poland for PPGGL].
abstract: BACKGROUND
  Differentiated thyroid carcinoma (DTC) in children presents different biological behavior in comparison to adults. Authors presents preliminary results of multicenter analysis concerning incidence, diagnostics and treatment of DTC in children.
  
  
  METHODS
  The study is a retrospective analysis of 107 pediatric patients from 14 academic centers based on the data from 2000 to 2005 obtained by questionnaire in hospitals involved in the treatment of DTC in children.
  
  
  RESULTS
  Papillary thyroid cancer was diagnosed in 83 children, follicular thyroid cancer in 10 children and medullary thyroid cancer in 14 children. Incidence of DTC in children was estimated between 18 and 23 cases per year. The biggest group of patients consisted of children between 11 and 15 years of age, with girls to boys ratio 3.3 : 1. Clinically DTC in children presented most often as solitary thyroid nodule. Cervical lymphadenopathy was observed in 42% of patients. Intraoperative verification indicated metastatic nodes in 50% of children. Low stage DTC predominated (T1 in 36% and T2 in 26% of children). One step surgery was performed in 65% of children with DTC, two step surgery in 25% of patients. I131 therapy was undertaken in 80% of children. Lung metastases were indicated in post therapeutic studies in 14% of children with DTC. Prophylactic thyroidectomies were performed in 79% of children in the group of patients with MTC and RET gene mutations.
  
  
  CONCLUSIONS
  The necessity of introduction of unified therapeutic standard in children with DTC in Poland is underlined.
authors.affiliation: Department of Pediatric Surgery Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum-Bydgoszcz, M. Skłodowskiej-Curie 9, Bydgoszcz. aprokurat@cm.umk.pl
authors.forename: Andrzej I
authors.initials: AI
authors.lastname: Prokurat
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Chrupek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pacholska
authors.forename: Przemysław
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authors.lastname: Gałazka
authors.forename: Jerzy
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authors.lastname: Harasymczuk
authors.forename: Andrzej
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authors.lastname: Jankowski
authors.forename: Marek
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authors.lastname: Niedziela
authors.forename: Eugeniusz
authors.initials: E
authors.lastname: Korman
authors.forename: Izabella
authors.initials: I
authors.lastname: Kozłowicz-Gudzińska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Czetwertyńska
authors.forename: Piotr
authors.initials: P
authors.lastname: Kaliciński
authors.forename: Dariusz
authors.initials: D
authors.lastname: Polnik
authors.forename: Jerzy
authors.initials: J
authors.lastname: Starzyk
authors.forename: Alicja
authors.initials: A
authors.lastname: Kalicka-Kasperczyk
authors.forename: Jerzy
authors.initials: J
authors.lastname: Czernik
authors.forename: Krystyna
authors.initials: K
authors.lastname: Sawicz-Birkowska
authors.forename: Maciej
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authors.lastname: Bagłaj
authors.forename: Anna
authors.initials: A
authors.lastname: Balcerska
authors.forename: Joanna
authors.initials: J
authors.lastname: Stefanowicz
authors.forename: Dorota
authors.initials: D
authors.lastname: Birkholz
authors.forename: Lech
authors.initials: L
authors.lastname: Pomorski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kaczka
authors.forename: Jarosław
authors.initials: J
authors.lastname: Peregud-Pogorzelski
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Petriczko
authors.forename: Jan
authors.initials: J
authors.lastname: Godziński
authors.forename: Joanna
authors.initials: J
authors.lastname: Ptaszyńska
authors.forename: Barbara
authors.initials: B
authors.lastname: Ziemniak
authors.forename: Wojciech
authors.initials: W
authors.lastname: Woźniak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bilska
authors.forename: Maria
authors.initials: M
authors.lastname: Górska
authors.forename: Anna
authors.initials: A
authors.lastname: Zonenberg
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*