[Antiplatelet effect of adenosine triphosphate administration to animals under different experimental conditions].
A significant and considerable decrease in abnormally high platelet aggregation has been demonstrated after intramuscular administration of sodium adenosine triphosphate (ATP) to rats with depressed anti-coagulant system (in aging rats at the age of 11-12 months) and to rats with experimental diabetes both preliminarily and at the background of progressing diabetes. The elimination of one of thrombotic risk factors (decreasing elevated platelet aggregation) points to possible antithrombotic activity of ATP under these experimental conditions.
Pastorova
V E
VE
Liapina
L A
LA
Ul'ianov
A M
AM
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000375:Aging / Q000097:blood*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D010975:Platelet Aggregation Inhibitors; D000255:Adenosine Triphosphate