Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.
[Structure: see text] A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.
Baumann
Marcus
M
Innovative Technology Center (ACS), Department of Chemistry, University of Cambridge, Cambridge, UK, CB2 1EW.
Baxendale
Ian R
IR
Ley
Steven V
SV
Smith
Christoper D
CD
Tranmer
Geoffrey K
GK