title: Intestinal lipids and minerals in streptozotocin-induced diabetic rats fed bitter yam (Dioscorea polygonoides) sapogenin extract.
abstract: Yam is the leading form of staple for millions of people in the tropical and subtropical countries. They are good sources of carbohydrate. However, the protein content of yam is low. The effect of bitter yam sapogenin extract or commercial diosgenin on faecal minerals and intestinal lipids in streptozotocin-induced diabetic rats was studied. Sapogenin extract or commercial diosgenin (1%) supplemented diets were fed to diabetic male Wistar rats for three weeks. Bitter yam sapogenin extract or commercial diosgenin did not significantly alter faecal magnesium, calcium, and zinc excretion but significantly decreased faecal sodium and potassium excretion. The absorption of iron was impaired by bitter yam sapogenin extract or commercial diosgenin during the first week of feeding. Bitter yam sapogenin extract or commercial diosgenin supplements significantly decreased intestinal lipids towards normal. Faecal lipids excreted was significantly higher in diabetic rats fed bitter yam sapogenin extract or commercial diosgenin for the three weeks period compared to the diabetic control group. These results show that bitter yam sapogenin extract or commercial diosgenin does not have the same effects on mineral excretion in diabetes. There was no direct correlation between the decrease in excretion of mono-valent cations and the activity of intestinal Na+/K+ATPase.
authors.affiliation: Biochemistry Section, Department of Basic Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica. f7omoruyi@yahoo.co.uk
authors.forename: Felix O
authors.initials: FO
authors.lastname: Omoruyi
authors.forename: Marie A
authors.initials: MA
authors.lastname: McAnuff-Harding
authors.forename: Helen N
authors.initials: HN
authors.lastname: Asemota
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D008076:Cholesterol, HDL / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D027742:Dioscorea / Q000737:chemistry*; D004144:Diosgenin / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D008903:Minerals / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013311:Streptozocin
chemical_list: D008076:Cholesterol, HDL; D008903:Minerals; D010936:Plant Extracts; D013311:Streptozocin; D000254:Sodium-Potassium-Exchanging ATPase; D004144:Diosgenin