title: The RADI PressureWire high-sensitivity thermistor and culprit lesion temperature in patients with acute coronary syndromes.
abstract: BACKGROUND
  Patients with acute coronary syndromes (ACS) have been shown to have a local increase in culprit lesion temperature of at least 0.5 degrees Celcius using a specialized thermography catheter. However, this device is unique, not clinically available and unable to provide information other than temperature. The 0.014-inch Radi PressureWire XT (RPW) contains a high-sensitivity thermistor in the sensor that has a sensitivity of 0.1 degrees Celcius. We evaluated the ability of the RPW to detect an increase in plaque temperature in patients with ACS.
  
  
  RESULTS
  Patients with ACS and a culprit lesion of > 70% stenosis and who were candidates for percutaneous coronary intervention (PCI) were eligible (n = 20). Fractional flow reserve (FFR) post-adenosine administration and temperature estimations were performed prior to PCI. All demographic data are presented as mean +/- SD, and temperature data (using delta temperature from baseline) as mean +/- SEM. Fifteen men and 5 women were enrolled (age 59.5 +/- 11.6 years). The FFR pre-PCI was 0.65 +/- 0.06, consistent with hemodynamically significant stenoses. The baseline delta temperature was 0.00 +/- 0.01 degrees Celcius. The delta temperature at the culprit lesion was -0.02 +/- 0.01 degrees Celcius (p = NS), a result below the resolution of the thermistor. Post-PCI, the FFR was 0.95 +/- 0.01 (p < 0.0001).
  
  
  CONCLUSIONS
  The RPW was unable to detect any temperature increase in patients with ACS.
authors.affiliation: Cardiovascular Investigation Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia. stephen.worthley@adelaide.edu.au
authors.forename: Stephen
authors.initials: S
authors.lastname: Worthley
authors.forename: M Omar
authors.initials: MO
authors.lastname: Farouque
authors.forename: Matthew
authors.initials: M
authors.lastname: Worthley
authors.forename: Mauro
authors.initials: M
authors.lastname: Baldi
authors.forename: Derek
authors.initials: D
authors.lastname: Chew
authors.forename: Ian
authors.initials: I
authors.lastname: Meredith
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation* / Q000379:methods; D001831:Body Temperature; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology; D004562:Electrocardiography; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000628:therapy*; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013817:Thermography / Q000295:instrumentation; D016896:Treatment Outcome; D014654:Vascular Patency