title: Structure-activity delineation of quinones related to the biologically active Calothrixin B.
abstract: Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucidate the mechanism of action of the Calothrixins, several related quinones were synthesized and tested for biological activity. The results of the structure-activity relationship (SAR) studies are reported here.
authors.affiliation: Department of Chemistry, Australian National University, Canberra, ACT 0200, Australia.
authors.forename: Paul H
authors.initials: PH
authors.lastname: Bernardo
authors.forename: Christina L L
authors.initials: CL
authors.lastname: Chai
authors.forename: Maurice
authors.initials: M
authors.lastname: Le Guen
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Smith
authors.forename: Paul
authors.initials: P
authors.lastname: Waring
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry*; D051379:Mice; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D026121:Indole Alkaloids; D011809:Quinones; C418327:calothrixin B