Quetiapine regulates the stress-induced increase in corticotropin-releasing factor mRNA expression in the rat hypothalamus.
Corticotropin-releasing factor (CRF) is a key regulator of the stress response. We investigated the effects of the atypical antipsychotic drug quetiapine on CRF mRNA expression in the rat hypothalamus following immobilization stress. Pretreatment with 10 mg/kg quetiapine significantly reduced the immobilization stress-induced increase in CRF mRNA expression in the paraventricular nucleus of the hypothalamus. These results suggest that quetiapine may modulate the stress response via regulation of CRF mRNA expression.
Park
Sung-Woo
SW
Department of Neuropsychiatry, School of Medicine, Paik Inje Memorial Clinical Research Institute, Inje University, Busan, Republic of Korea.
Lee
Sun-Kyung
SK
Kim
Jae-Min
JM
Kang
Ho-Cheol
HC
Yoon
Jin-Sang
JS
Kim
Young-Hoon
YH
D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D003987:Dibenzothiazepines / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D000069348:Quetiapine Fumarate; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000473:pathology* / Q000503:physiopathology
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D012333:RNA, Messenger; D000069348:Quetiapine Fumarate; D003346:Corticotropin-Releasing Hormone