title: Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells.
abstract: Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells.
authors.affiliation: Institute of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Szeged, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Baráth
authors.forename: Rita
authors.initials: R
authors.lastname: Radics
authors.forename: Gabriella
authors.initials: G
authors.lastname: Spengler
authors.forename: Imre
authors.initials: I
authors.lastname: Ocsovszki
authors.forename: Masami
authors.initials: M
authors.lastname: Kawase
authors.forename: Noboru
authors.initials: N
authors.lastname: Motohashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Shirataki
authors.forename: Anamik
authors.initials: A
authors.lastname: Shah
authors.forename: József
authors.initials: J
authors.lastname: Molnár
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002867:Chromones / Q000737:chemistry / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D019450:Genes, MDR; D006801:Humans; D016399:Lymphoma, T-Cell / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D014162:Transfection
chemical_list: D002867:Chromones; C502480:formylchromone