title: Prevalent genotypes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) in spontaneously aborted embryos.
abstract: OBJECTIVE
  To assess prevalent 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms in spontaneously aborted embryos.
  
  
  METHODS
  A retrospectively analyzed, prospectively obtained database.
  
  
  METHODS
  Bundang CHA General Hospital and Kangnam CHA Hospital.
  
  
  METHODS
  Ninety-four spontaneously aborted embryos at <20 weeks of gestational age.
  
  
  METHODS
  None.
  
  
  METHODS
  Genotype frequency of MTHFR C677T and A1298C polymorphisms in spontaneously aborted embryos.
  
  
  RESULTS
  The aborted embryos exhibited both a significantly high frequency of the MTHFR 677CC genotype and a low frequency of the MTHFR 677CT genotype, compared to both the child and the adult control groups, respectively, whereas no significant change in the fetal MTHFR A1298C genotype frequency was observed. The combinative genotype of MTHFR 677CC/1298AC from the abortus had a high prevalence compared to the child controls. Further, the chromosomal integrity of the abortus did not affect the frequency of the MTHFR 677CC and 1298AC genotypes.
  
  
  CONCLUSIONS
  Spontaneously aborted embryos have a unique distribution of MTHFR C677T and A1289C polymorphisms, regardless of their chromosomal integrity.
authors.affiliation: Institute for Clinical Research, Bundang CHA General Hospital, College of Medicine, Seongnam, South Korea.
authors.forename: Jeehyeon
authors.initials: J
authors.lastname: Bae
authors.forename: Seung Joo
authors.initials: SJ
authors.lastname: Shin
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Cha
authors.forename: Dong Hee
authors.initials: DH
authors.lastname: Choi
authors.forename: Suman
authors.initials: S
authors.lastname: Lee
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000022:Abortion, Spontaneous / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics*; D004252:DNA Mutational Analysis; D004622:Embryo, Mammalian / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)