[Physiological and biochemical effects of intermittent fasting combined with hunger-resistant food on mice].
OBJECTIVE
To observe the physiological and biochemical effects of intermittent fasting combined with hunger-resistant food on mice, and to evaluate the safety and beneficial effects of this regimen.


METHODS
One hundred and forty-four adult ICR mice were divided into 4 groups: standard feed AL group (ad libitum intake of standard feed), hunger-resistant food AL group (ad libitum intake of hunger-resistant food), standard feed IF group (feeding standard feed and fasting on alternate days), and hunger-resistant food IF group (feeding hunger-resistant food and fasting on alternate days). The experiment lasted for 4-8 weeks and all mice drank water freely. The quality of life, body weight, fasting blood glucose, serum lipid, blood routine test, liver and kidney functions as well as the viscera indexes were examined.


RESULTS
Compared to the standard feed AL group, the caloric taking and the increment of body-weight were reduced (P<0.01), and the viscera indexes of the liver and kidney were elevated (P<0.05) in the hunger-resistant food AL group and the hunger-resistant food IF group, the values of fasting blood glucose were reduced in standard feed IF group and hunger-resistant food IF group (P<0.01), the value of triglycerides was reduced in hunger-resistant food IF group (P<0.05), while the quality of life, blood routine test as well as the liver and kidney functions were not obviously affected in the hunger-resistant food AL group, standard feed IF group and hunger-resistant food IF group.


CONCLUSIONS
The regimen of intermittent fasting combined with hunger-resistant food is safe and beneficial to metabolic regulation, such as controlling body-weight and adjusting blood glucose and serum lipid. It is expected that development of this regimen will be helpful to the control of obesity and diabetes, etc.
Shen
Xiao-Dong
XD
Shanghai Qigong Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China. sh_xd001@163.com
Hua
Wei-Guo
WG
Chu
Wei-Zhong
WZ
Xu
Feng
F
Wang
Yu-Ying
YY
Chen
Hui-Ju
HJ
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D004038:Diet, Reducing; D002149:Energy Intake / Q000502:physiology*; D005215:Fasting / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology*; D006815:Hunger / Q000502:physiology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
D001786:Blood Glucose