title: Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy.
abstract: BACKGROUND
  Despite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment.
  
  
  OBJECTIVE
  The aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control.
  
  
  METHODS
  We evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obese participants (17.01+/-1.6 years old; body mass index 36.54+/-2.86 kg/m), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed.
  
  
  RESULTS
  The results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05+/-1.55 to 3.37+/-1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents.
  
  
  CONCLUSIONS
  The short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.
authors.affiliation: Federal University of São Paulo, Paulista Medicine School, UNIFESP, EPM, São Paulo, Brazil.
authors.forename: Lian
authors.initials: L
authors.lastname: Tock
authors.forename: Wagner L
authors.initials: WL
authors.lastname: Prado
authors.forename: Danielle A
authors.initials: DA
authors.lastname: Caranti
authors.forename: Dejaldo M J
authors.initials: DM
authors.lastname: Cristofalo
authors.forename: Henrique
authors.initials: H
authors.lastname: Lederman
authors.forename: Mauro
authors.initials: M
authors.lastname: Fisberg
authors.forename: Kãli O
authors.initials: KO
authors.lastname: Siqueira
authors.forename: Sérgio G
authors.initials: SG
authors.lastname: Stella
authors.forename: Hanna K
authors.initials: HK
authors.lastname: Antunes
authors.forename: Isa P
authors.initials: IP
authors.lastname: Cintra
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
authors.forename: Ana R
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D004435:Eating; D015444:Exercise; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000097:blood; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids