Increased IL-13-producing T cells in ALS: positive correlations with disease severity and progression rate.
We measured the intracellular productions of IFNgamma, IL-2, IL-4, IL-13 and TNFalpha in peripheral blood CD4(+) and CD8(+) T cells from 21 amyotrophic lateral sclerosis (ALS) patients, 14 disease controls (DC) with spinocerebellar degeneration and 16 healthy controls (HC). Only the percentages of CD4(+)IL-13(+) and CD8(+)IL-13(+) T cells were significantly higher in ALS patients than in DC and HC. The CD4(+)IL-13(+) T cell percentages showed a significant negative correlation with the revised ALS functional rating scale scores and significant positive correlation with the disease progression rate, suggesting that IL-13 contributes to ALS.
Shi
Nan
N
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kawano
Yuji
Y
Tateishi
Takahisa
T
Kikuchi
Hitoshi
H
Osoegawa
Manabu
M
Ohyagi
Yasumasa
Y
Kira
Jun-ichi
J
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D018793:Interleukin-13 / Q000096:biosynthesis*; D007425:Intracellular Membranes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000378:metabolism* / Q000473:pathology*
D016207:Cytokines; D018793:Interleukin-13; D007073:Immunoglobulin E