Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.
Liang
Winnie S
WS
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Dunckley
Travis
T
Beach
Thomas G
TG
Grover
Andrew
A
Mastroeni
Diego
D
Walker
Douglas G
DG
Caselli
Richard J
RJ
Kukull
Walter A
WA
McKeel
Daniel
D
Morris
John C
JC
Hulette
Christine
C
Schmechel
Donald
D
Alexander
Gene E
GE
Reiman
Eric M
EM
Rogers
Joseph
J
Stephan
Dietrich A
DA
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000378:metabolism
D009419:Nerve Tissue Proteins; D012313:RNA