Disturbance of erythrocyte lipid bilayer by amino acid-based surfactants.
In an attempt to increase our knowledge regarding the mechanisms of surfactant membrane interaction, we studied the action of several anionic and cationic amino acid-based surfactants on membrane fluidity using fluorescence anisotropy. Anisotropy measurements demonstrated that almost all of the surfactants studied disturbed the external region of the erythrocyte membrane without affecting the core of the bilayer. How the physico-chemical properties and structure of these compounds affect dynamics of the lipid bilayer is discussed in detail.
Martínez
V
V
Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain.
Sánchez
L
L
Busquets
M A
MA
Infante
M R
MR
Pilar Vinardell
M
M
Mitjans
M
M
D000596:Amino Acids / Q000737:chemistry*; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000187:drug effects; D005454:Fluorescence Polarization; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity / Q000187:drug effects*; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology
D000596:Amino Acids; D008051:Lipid Bilayers; D013501:Surface-Active Agents