Ethanol impairs coagulation and fibrinolysis in whole blood: a study performed with rotational thromboelastometry.
The objective was to study the effects of ethanol on coagulation and fibrinolysis in whole blood. Blood samples from healthy volunteers were analyzed before and after in-vitro addition of ethanol in order to achieve ethanol concentrations of 0, 1, 2 and 4 per thousand, respectively (0, 22, 44 and 88 mmol/l). Coagulation and fibrinolysis were then assessed using rotational thromboelastometry. We found that increasing ethanol levels increasingly impaired coagulation as evaluated with rotational thromboelastometry, with a maximum prolongation of the clot formation time of 118% at an ethanol level of 4 per thousand (P < 0.000001). We also found a very strong impairment of fibrinolysis already at an ethanol level of 1 per thousand. This is the first study assessing the effects of ethanol on coagulation and fibrinolysis in a whole blood model. The impairment of coagulation is similar in nature to the impairment found in patients suffering from hypothermia. The impairment is at a level that may be of clinical importance (e.g. in patients suffering from trauma). The inhibition of fibrinolysis is obvious already at an ethanol level of 1 per thousand and it may be a contributing factor to the increased amount of coronary and cerebrovascular ischemic events after binge drinking.
Engström
Martin
M
Department of Anaesthesia and Intensive Care, Lund University Hospital, Lund, Sweden. martin.engstrom@med.lu.se
Schött
Ulf
U
Reinstrup
Peter
P
D000428:Alcohol Drinking / Q000009:adverse effects; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D002492:Central Nervous System Depressants / Q000009:adverse effects* / Q000097:blood; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D005342:Fibrinolysis / Q000187:drug effects*; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D066298:In Vitro Techniques; D013916:Thrombelastography
D002492:Central Nervous System Depressants; D000431:Ethanol