title: Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl.LiCl.
abstract: The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl.LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained. [reaction: see text].
authors.affiliation: Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Lin
authors.forename: Oliver
authors.initials: O
authors.lastname: Baron
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D000215:Acylation; D001554:Benzene / Q000138:chemical synthesis*; D001577:Benzophenones / Q000138:chemical synthesis; D002219:Carbamates / Q000138:chemical synthesis; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry; D018021:Lithium Chloride / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D002219:Carbamates; D007202:Indicators and Reagents; D007659:Ketones; D003300:Copper; D018021:Lithium Chloride; D008274:Magnesium; D001554:Benzene