title: Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy.
abstract: We compared the cognitive functions and interictal cerebral glucose metabolism of 11 patients with mesial temporal lobe epilepsy (MTLE) with frequent seizures to those of 10 patients with MTLE with rare seizures; the groups were matched for age, sex, education, IQ, and focus side. The frequent-seizure group had more set-shifting impairment that correlated with glucose hypometabolism in the prefrontal cortices. Our results suggest that frequent seizures in MTLE are associated with hypofunction of the prefrontal cortex.
authors.affiliation: Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takaya
authors.forename: T
authors.initials: T
authors.lastname: Hanakawa
authors.forename: K
authors.initials: K
authors.lastname: Hashikawa
authors.forename: A
authors.initials: A
authors.lastname: Ikeda
authors.forename: N
authors.initials: N
authors.lastname: Sawamoto
authors.forename: T
authors.initials: T
authors.lastname: Nagamine
authors.forename: K
authors.initials: K
authors.lastname: Ishizu
authors.forename: H
authors.initials: H
authors.lastname: Fukuyama
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology; D004827:Epilepsy / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D007839:Functional Laterality / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D012718:Set, Psychology
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose