Dual renal transplantation for kidneys from marginal non-heart-beating donors.
Kidneys transplanted from non-heart-beating donors (NHBD) are generally regarded as marginal or extended criteria grafts due to the associated period of warm ischemia. The most prolonged periods occurring in the category II (uncontrolled) donor. This potential for injury can adversely affect the glomular filtration rate (GFR), which in severe cases results in primary nonfunction. Viability testing can identify a group of kidneys that, although unsuitable for solitary transplantation, may be considered for dual transplant. This retrospective study examined a series of 11 dual renal transplants, comparing 3- and 12-month GFR outcome data with 81 single NHBD transplants. The mean GFR at 3 months in the dual group was 47.6 and at 12 months was 48.6. In the single group the GFR at 3 months was 40.6 and at 12 months was 41.9. Thus using viability testing to identify NHBD kidneys suitable for dual transplant appears reliable and predictable.
Navarro
A P
AP
Liver and Renal Transplant Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom. alex@navarrol.wanadoo.co.uk
Sohrabi
S
S
Wyrley-Birch
H
H
Vijayanand
D
D
Wilson
C
C
Sanni
A
A
Reddy
M
M
Manas
D
D
Rix
D
D
Talbot
D
D
D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006323:Heart Arrest; D006801:Humans; D007668:Kidney; D016030:Kidney Transplantation / Q000502:physiology*; D009392:Nephrectomy / Q000379:methods; D018579:Patient Selection; D012189:Retrospective Studies; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods*; D009927:Tissue and Organ Procurement / Q000379:methods*