title: Cytomegalovirus infection complicating immunosuppressive therapy for dermatomyositis.
abstract: The occurrence of opportunistic infections is not rare during the treatment of connective tissue diseases, including dermatomyositis because of the patient's immunosuppression. We describe here cytomegalovirus (CMV) infection that affected two of our patients with dermatomyositis. CMV infection has not been considered to be a frequent event in dermatomyositis, and its significance for disease progression has not been sufficiently recognized. Our case reports demonstrate the importance of close monitoring of such patients and prompt initiation of appropriate therapy to manage a suspected CMV infection.
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Okuyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Hachiro
authors.initials: H
authors.lastname: Tagami
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone; D015774:Ganciclovir