Interaction between Shaoyao-Gancao-Tang and a laxative with respect to alteration of paeoniflorin metabolism by intestinal bacteria in rats.
Shaoyao-Gancao-Tang (SGT), a traditional Chinese herbal medicine (Kampo formulation) containing Shaoyao (Paeoniae Radix) and Gancao (Glycyrrhizae Radix), is co-administered with laxative sodium picosulfate as a premedication for relieving the pain accompanying colonoscopy. Paeoniflorin (PF), an active glycoside of SGT, is metabolized into the antispasmodic agent paeonimetabolin-I (PM-I) by intestinal bacteria after oral administration. The objective of the present study was to investigate whether the co-administered laxative (sodium picosulfate) influences the metabolism of PF to PM-I by intestinal bacteria. We found that the PF-metabolizing activity of intestinal bacteria in rat feces was significantly reduced to approximately 34% of initial levels by a single sodium picosulfate pretreatment and took approximately 6 days to recover. Repeated administration of SGT after the sodium picosulfate pretreatment significantly shortened the recovery period to around 2 days. Similar results were also observed for plasma PM-I concentration. Since PM-I has muscle relaxant activity, the present results suggest that repetitive administration of SGT after sodium picosulfate pretreatment might be useful to relieve the pain associated with colonoscopy.
He
Ju-Xiu
JX
Institute of Natural Medicine, Toyama, Japan.
Goto
Emi
E
Akao
Teruaki
T
Tani
Tadato
T
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D019540:Area Under Curve; D001419:Bacteria / Q000378:metabolism*; D001565:Benzoates / Q000737:chemistry / Q000378:metabolism*; D001952:Bridged-Ring Compounds / Q000097:blood / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D002400:Cathartics / Q000494:pharmacology; D002951:Citrates; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005243:Feces / Q000382:microbiology; D005960:Glucosides / Q000737:chemistry / Q000378:metabolism*; D006207:Half-Life; D007422:Intestines / Q000382:microbiology*; D008297:Male; D015394:Molecular Structure; D039821:Monoterpenes; D009942:Organometallic Compounds; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D006027:Glycosides
D000700:Analgesics; D001565:Benzoates; D001952:Bridged-Ring Compounds; D002400:Cathartics; D002951:Citrates; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D039821:Monoterpenes; D009942:Organometallic Compounds; D010847:Picolines; C522934:8-phenylthiopaeonimetabolin I; C499903:jackyakamcho-tang; C015423:peoniflorin; D006027:Glycosides; C106915:paeonimetabolin I; C005701:picosulfate sodium