Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis.
[Structure: see text] Three new compounds, kalanchosides A-C (1-3), as well as five known compounds, were isolated from the aerial parts of Kalanchoe gracilis. The compound structures were determined by spectroscopic methods. All eight isolated compounds showed significant cytotoxic activity against a panel of human tumor cell lines, with potency reaching the nanomolar range. However, only bryophyllin B (8) inhibited HIV replication in H9 lymphocyte cells.
Wu
Pei-Lin
PL
Department of Cosmetic Science, Chung Hwa College of Medical Technology, Tainan 717, Taiwan, Republic of China. wupl@mail.ncku.edu.tw
Hsu
Yu-Lin
YL
Wu
Tian-Shung
TS
Bastow
K F
KF
Lee
Kuo-Hsiung
KH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002018:Bufanolides / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D031962:Kalanchoe / Q000737:chemistry*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D035261:Plant Components, Aerial / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
C517069:12-oxohellebrigenin-3-O-4,6-dideoxyhexopyranoside; D000972:Antineoplastic Agents, Phytogenic; D002018:Bufanolides; D012503:Saponins; C517067:hellebrigenin-3-O-6'-deoxyglucopyranoside; C517068:hellebrigenin-3-O-fucopyranoside