Hepatitis B virus inhibiting constituents from Herpetospermum caudigerum.
From the ethanol extract of the seeds of Herpetospermum caudigerum wall, one new lignan compound 1, was isolated and characterized along with three known compounds 2, 3 and 4. The structure elucidation of the isolated new compound was performed on the basis of spectroscopic and chemical evidence. The structures of known compounds were determined by comparison of spectral data and physical data with those previously reported. The activity inhibiting hepatitis b virus was evaluated. Preliminary studies showed that compound 1 and 2 displayed promising inhibitory potential against hepatitis b virus.
Yuan
Hai-Long
HL
302 Hospital of PLA&PLA Institute of Chinese Materia Medica, Beijing, China. yhalpharm@126.com
Yang
Ming
M
Li
Xian-Yi
XY
You
Rong-Hui
RH
Liu
Yi
Y
Zhu
Jun
J
Xie
Huan
H
Xiao
Xiao-He
XH
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D019662:Cucurbitaceae / Q000737:chemistry*; D004247:DNA / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013045:Species Specificity; D013237:Stereoisomerism; D013997:Time Factors; D014407:Tumor Cells, Cultured
D000998:Antiviral Agents; D008024:Ligands; D010936:Plant Extracts; D004247:DNA