Hormonal influence on periurethral vessels in postmenopausal incontinent women using Doppler velocimetry analysis.
The lack of estrogen affects the urinary tract mainly by diminishing vascular, muscular and epithelial trophism, resulting in negative effects on continence in postmenopausal women.


OBJECTIVE
Study the effect of hormone therapy (estrogen and progesterone) in periurethral vessels detected by Doppler velocimetric analysis using, as parameters, the number of vessels, resistance and pulsatility indexes, as well as the minimum diastolic value.


METHODS
Thirty-eight postmenopausal women with stress urinary incontinence were randomized into two groups. The first consisted of women receiving 3 months of estrogen therapy previous to 3 months of continuous estrogen and progesterone combined therapy. The second comprised of women receiving 3 months of continuous estrogen and progesterone therapy. Periurethral Doppler velocimetric analysis was done before hormone administration and during treatment in both groups.


RESULTS
We observed a statistically significant increased number of periurethral vessels during treatment in both groups. There was an increase in value of the mean minimum diastolic value during estrogen and progesterone therapy in Group 2. The resistance indexes diminished in both groups. However, they were not statistically significant.


CONCLUSIONS
Hormonal therapy of short duration (3-6 months) had a positive effect on the urethral continence mechanism increasing the number of periurethral vessels either with estrogen alone or combined therapy (estrogen and progesterone).
Jármy-Di Bella
Z I K
ZI
Department of Gynecology at Escola Paulista de Medicina, Federal University of São Paulo, Brazil. zsuvi@uol.com.br
Girão
M J B C
MJ
Di Bella
V
V
Sartori
M G F
MG
Szejnfeld
J
J
Baracat
E C
EC
Lima
G R
GR
D000328:Adult; D000368:Aged; D001808:Blood Vessels / Q000503:physiopathology*; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D011374:Progesterone / Q000627:therapeutic use; D014463:Ultrasonography; D014521:Urethra / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D014550:Urinary Incontinence, Stress / Q000188:drug therapy / Q000503:physiopathology*; D014655:Vascular Resistance / Q000502:physiology
D004967:Estrogens; D011374:Progesterone