The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.
Attention-deficit/hyperactivity disorder (ADHD) is a heritable disease. Serotonin is one of the neurotransmitters involved in the etiology of ADHD. Serotonin-1D receptors are autoreceptors which can regulate the release of serotonin in brain, so the HTR1D gene may be predisposing. The current study genotyped two variants of HTR1D gene in 272 ADHD trios of Chinese ethnicity, that is 1350T > C in the coding region and 1236A > G in 3'-UTR by the use of transmission disequilibrium test (TDT). The A allele of the 1236A > G polymorphism exhibited both a trend toward preferential transmission to ADHD probands (chi2 = 3.815, P = 0.051) and a significant preferential transmission to probands of ADHDC (chi2 = 4.198, P = 0.040). Additional polymorphisms in this gene need to be studied further.
Li
Jun
J
Institute of Mental Health, Peking University (Peking University Sixth Hospital), Beijing 100083, China.
Zhang
Xia
X
Wang
Yufeng
Y
Zhou
Rulun
R
Zhang
Haobo
H
Yang
Li
L
Wang
Bing
B
Faraone
Stephen V
SV
D044466:Asian People / Q000235:genetics; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D011110:Polymorphism, Genetic; D044346:Receptor, Serotonin, 5-HT1D / Q000235:genetics*
D044346:Receptor, Serotonin, 5-HT1D