Enantioselective equilibration-access to chiral aldol adducts of mandelic acid esters.
[Structure: see text] Syn-configured aldol products of mandelic acid esters and aldehydes were synthesized by the catalytic use of amines in the presence of titanium(IV) tert-butoxide. Used along with chiral N-methylephedrine, anti-configured alpha,beta-dihydroxyesters were isolated with a high degree of enantioselectivity for the first time.
Scholtis
Stefan
S
Humboldt-Universität zu Berlin, Institut für Chemie, Brook-Taylor Strasse 2, 12489 Berlin, Germany.
Ide
Andreas
A
Mahrwald
Rainer
R