title: Blood cell and plasma protein repellent properties of star-PEG-modified surfaces.
abstract: The implantation of biomaterials, medical devices or prostheses can instigate a rejection response or initiate an undesirable adsorption of plasma proteins, as well as blood cells on the implant surface, thus triggering diverse defense mechanisms against the supposed pathologic invader. The extent of this inflammatory reaction depends in part on the biocompatibility of the used materials or coatings. Although adsorption and coagulation responses can appear during the total in vivo lifetime of the implant, they are initially and crucially formed within the first 2-4 weeks of implantation. This early phase is of decisive importance for the consecutive in-growth and healing process. The present study was intended to elucidate the effects of blood contact to surfaces modified with reactive six-arm star-shaped poly(ethylene glycol-stat-propylene glycol) pre-polymers (Star PEG). Taken together, for Star-PEG-covered substrates we could demonstrate a profound reduction of various blood-biomaterial interactions compared to non-coated substrates, indicating the promising potential of this material as future coating for biomaterials with blood contact.
authors.affiliation: Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Calwerstr 7/1, D-72076 Tübingen, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Hoffmann
authors.forename: Jürgen
authors.initials: J
authors.lastname: Groll
authors.forename: Jean
authors.initials: J
authors.lastname: Heuts
authors.forename: Haitao
authors.initials: H
authors.lastname: Rong
authors.forename: Doris
authors.initials: D
authors.lastname: Klee
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ziemer
authors.forename: Martin
authors.initials: M
authors.lastname: Moeller
authors.forename: Hans P
authors.initials: HP
authors.lastname: Wendel
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000494:pharmacology*; D001773:Blood Cells / Q000737:chemistry* / Q000166:cytology; D001798:Blood Proteins / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D040201:Platelet Membrane Glycoprotein IIb / Q000032:analysis; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology*; D013499:Surface Properties; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D040201:Platelet Membrane Glycoprotein IIb; D011108:Polymers; D011409:Propylene Glycols; D001620:beta-Thromboglobulin; C012504:polypropylene glycol; D011092:Polyethylene Glycols