title: [Importance of subchondral bone and synovial membrane on the pathogenesis and treatment of osteoarthritis].
abstract: Osteoarthritis (OA) is one of the most prevalent diseases of the musculoskeletal system, and it is caused by an unbalance in chondrocyte homeostasis. Although the chondrocyte is considered the key element in the maintenance of cartilage homeostasis, other structures like subchondral bone and synovial membrane are also involved in the development and progression of OA. In fact, OA is considered an example of a global failure of joint structures. In this paper, we will review the role of subchondral bone and synovium in the pathogenesis of OA, as well as their possible therapeutic implications.
authors.affiliation: Hospital de la Princesa, Madrid.
authors.forename: S
authors.initials: S
authors.lastname: Castañeda Sanz
authors.forename: J
authors.initials: J
authors.lastname: Bruges-Armas
authors.forename: G
authors.initials: G
authors.lastname: Herrero-Beaumont
mesh_terms: D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology*; D002356:Cartilage / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy / Q000209:etiology*; D013583:Synovial Membrane / Q000187:drug effects / Q000502:physiology*