Risk of rupture in unruptured anterior communicating artery aneurysms: meta-analysis of natural history studies.
BACKGROUND
The decision of whether to operate on patients bearing UIAs is complicated by the limitations in current knowledge of the natural history of such lesions. The ISUIA has estimated the annual risk of rupture below that justifying surgery for most incidentally found lesions less than 7 mm in diameter. However, there is some evidence that aneurysms located in the ACoA show a higher risk of rupture, even with diameters of less than 7 mm. The present study was conducted to investigate the risk of aneurysm rupture in this site.


METHODS
The available literature on the subject was thoroughly reviewed, and a meta-analysis was carried out comparing the risk of rupture of aneurysms found in the ACoA with that of aneurysms in other sites.


RESULTS
Aneurysms found unruptured in the ACoA show a risk of rupture twice as high as that of other intracranial aneurysms (95% confidence interval, 1.29-3.12). It is the first time this fact has been demonstrated based on the follow-up of unruptured aneurysms.


CONCLUSIONS
When deciding whether to operate on UIAs located in the ACoA, surgeons should consider their higher risk of rupture.
Mira
Juan Marcos Suárez
JM
Departamento de Neurocirurgia, Hospital Santa Casa de Misericórdia, Santana do Livramento, Rio Grande do Sul, Brazil. juanmira@ig.com.br <juanmira@ig.com.br>
Costa
Fernando Antonio De Oliveira
FA
Horta
Bernardo Lessa
BL
Fabião
Othello Moreira
OM
D017542:Aneurysm, Ruptured / Q000209:etiology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000473:pathology; D018570:Risk Assessment