title: Local delivery of doxorubicin for malignant glioma by a biodegradable PLGA polymer sheet.
abstract: Implantable, biocompatible and biodegradable devices bearing an anticancer drug can provide promising local therapy to patients with malignant disorders. With the aim of treating brain tumors, especially gliomas, a membranous sheet containing doxorubicin was produced by co-polymerization to poly(D,L-lactide-co-glycolide) (PLGA). When release of the drug from the sheet was measured, sustained release continued until day 34. The data contrasted with the burst release from material containing a higher proportion of the drug. In terms of biodegradability, a subcutaneous 3 x 3-mm tetragonal sheet was almost completely absorbed by day 80. When a glioma was implanted subcutaneously and the tumor nodule exposed to the sheet, the device inhibited tumor growth significantly. The sheet consisted of an amorphous structure with cavities estimated to have a diameter of 0.5 - 3 microm by electron microscopic observation. Since the sheet is implantable, biodegradable and has a sustained-drug release property, the device may play a role in the local therapy of brain tumors.
authors.affiliation: Department of Molecular Cell Biology, Institute of DNA Medicine, Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan. manome@jikei.ac.jp
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Manome
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Mariko
authors.initials: M
authors.lastname: Mori
authors.forename: Rie
authors.initials: R
authors.lastname: Suzuki
authors.forename: Naotake
authors.initials: N
authors.lastname: Funamizu
authors.forename: Nobutake
authors.initials: N
authors.lastname: Akiyama
authors.forename: Sachiko
authors.initials: S
authors.lastname: Inoue
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
authors.forename: Michiko
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D019344:Lactic Acid / Q000737:chemistry*; D008863:Microspheres; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000903:Antibiotics, Antineoplastic; D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin