title: [Cartilage formation and regeneration by mechanical stress].
abstract: Every cell in our body is subject to mechanical stress and responds to mechanical stimulation. Especially, tissues which function as a supportive tissue such as bone or cartilage utilize these stimulation during tissue formation and maintenance. Several lines of extensive studies have revealed the effects and mechanisms of mechanotransduction in cartilage or three dimensional engineered tissue. Furthermore, these biological responses to mechanical stimulation are thought to enhance cartilage formation or regeneration in vitro . Mechanical stimulation to a cultured tissue is thought to be a feasible strategy to develop a new cartilage therapy.
authors.affiliation: Osaka University Graduate School of Medicine, Department of Orthopaedic Surgery.
authors.forename: Ken
authors.initials: K
authors.lastname: Nakata
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D016025:Bone Transplantation; D002356:Cartilage / Q000502:physiology*; D002478:Cells, Cultured; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D010812:Physical Stimulation; D013314:Stress, Mechanical; D023822:Tissue Engineering
chemical_list: D048049:Extracellular Signal-Regulated MAP Kinases; D020928:Mitogen-Activated Protein Kinases