title: Effect of living donor liver transplantation on outcome of children with inherited liver disease and hepatocellular carcinoma.
abstract: We described six children with heritable liver disease and hepatocellular carcinoma treated with living-related liver transplantation. Underlying liver diseases were type-1 tyrosinemia (three patients), progressive familial intrahepatic cholestasis type II (two patients), and Wilson's disease (one patient). Two of the tumors were found incidentally during liver transplantation. Number of nodules was 12, 15, 3, 2, and 1 (in two patients). Three patients were treated with chemotherapy before the procedure. Chemotherapy was not given to any patient after liver transplantation. The mean follow-up was 17.7 +/- 6 months (range: 7-24). All patients are tumor recurrence free. Both graft and patient survival rates are 100% at a median of 18.5 months follow-up. Physicians in charge of treating children with heritable liver disease should screen them periodically for the development of hepatocellular carcinoma. Liver transplantation may offer these children better survival rates.
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Baskent University Faculty of Medicine, Ankara, Turkey. fozcay@yahoo.com
authors.forename: Figen
authors.initials: F
authors.lastname: Ozçay
authors.forename: Oğuz
authors.initials: O
authors.lastname: Canan
authors.forename: Banu
authors.initials: B
authors.lastname: Bilezikçi
authors.forename: Adnan
authors.initials: A
authors.lastname: Torgay
authors.forename: Hamdi
authors.initials: H
authors.lastname: Karakayali
authors.forename: Mehmet
authors.initials: M
authors.lastname: Haberal
mesh_terms: D000293:Adolescent; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D002780:Cholestasis, Intrahepatic / Q000151:congenital / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006527:Hepatolenticular Degeneration / Q000473:pathology / Q000601:surgery*; D006801:Humans; D015994:Incidence; D007223:Infant; D017093:Liver Failure / Q000453:epidemiology / Q000209:etiology; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D020176:Tyrosinemias / Q000473:pathology / Q000601:surgery*