title: Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.
abstract: Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.
authors.affiliation: Molecular Neurobiology, Department of Biology-Chemistry-Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.
authors.forename: Niels
authors.initials: N
authors.lastname: Plath
authors.forename: Ora
authors.initials: O
authors.lastname: Ohana
authors.forename: Björn
authors.initials: B
authors.lastname: Dammermann
authors.forename: Mick L
authors.initials: ML
authors.lastname: Errington
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schmitz
authors.forename: Christina
authors.initials: C
authors.lastname: Gross
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Mao
authors.forename: Arne
authors.initials: A
authors.lastname: Engelsberg
authors.forename: Claudia
authors.initials: C
authors.lastname: Mahlke
authors.forename: Hans
authors.initials: H
authors.lastname: Welzl
authors.forename: Ursula
authors.initials: U
authors.lastname: Kobalz
authors.forename: Anastasia
authors.initials: A
authors.lastname: Stawrakakis
authors.forename: Esperanza
authors.initials: E
authors.lastname: Fernandez
authors.forename: Robert
authors.initials: R
authors.lastname: Waltereit
authors.forename: Anika
authors.initials: A
authors.lastname: Bick-Sander
authors.forename: Eric
authors.initials: E
authors.lastname: Therstappen
authors.forename: Sam F
authors.initials: SF
authors.lastname: Cooke
authors.forename: Veronique
authors.initials: V
authors.lastname: Blanquet
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wurst
authors.forename: Benedikt
authors.initials: B
authors.lastname: Salmen
authors.forename: Michael R
authors.initials: MR
authors.lastname: Bösl
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Lipp
authors.forename: Seth G N
authors.initials: SG
authors.lastname: Grant
authors.forename: Tim V P
authors.initials: TV
authors.lastname: Bliss
authors.forename: David P
authors.initials: DP
authors.lastname: Wolfer
authors.forename: Dietmar
authors.initials: D
authors.lastname: Kuhl
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal; D015139:Blotting, Southern / Q000379:methods; D015153:Blotting, Western / Q000379:methods; D003214:Conditioning, Classical / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000172:deficiency / Q000502:physiology*; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D019706:Excitatory Postsynaptic Potentials / Q000235:genetics / Q000502:physiology; D006624:Hippocampus / Q000166:cytology; D066298:In Vitro Techniques; D007608:Kainic Acid; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000502:physiology*; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D018408:Patch-Clamp Techniques / Q000379:methods; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism; D013037:Spatial Behavior / Q000502:physiology; D013569:Synapses / Q000235:genetics / Q000502:physiology*; D013997:Time Factors
chemical_list: D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; C092069:activity regulated cytoskeletal-associated protein; D007608:Kainic Acid