High rate multiple drug resistances in HIV-infected patients failing nonnucleoside reverse transcriptase inhibitor regimens in Thailand, where subtype A/E is predominant.
The prevalence of drug resistance was determined among 64 HIV-infected Thai patients who were failed while receiving nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens. Eighty-nine percent of patients had 1 or more NNRTI mutation resistances. Almost all patients had resistance to at least 1 nucleoside reverse transcriptase inhibitor (NRTI), and 42% had multiple-NRTI resistance.
Chetchotisakd
Ploenchan
P
Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand. ploencha@kku.ac.th
Anunnatsiri
Siriluck
S
Kiertiburanakul
Sasisopin
S
Sutthent
Ruengpung
R
Anekthananon
Thanomsak
T
Bowonwatanuwong
Chureeratana
C
Kowadisaiburana
Boonchai
B
Supparatpinyo
Khuanchai
K
Horsakulthai
Manassinee
M
Chasombat
Sanchai
S
Ruxrungtham
Kiat
K
D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000235:genetics*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D013785:Thailand / Q000453:epidemiology; D017211:Treatment Failure
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase