title: In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
abstract: RWJ-416457, an investigational pyrrolopyrazolyl-substituted oxazolidinone, inhibited the growth of linezolid-susceptible staphylococci, enterococci, and streptococci at concentrations of < or =4 microg/ml, generally exhibiting two- to fourfold-greater potency than that of linezolid. Time-kill studies demonstrated bacteriostatic effects for both RWJ-416457 and linezolid.
authors.affiliation: Johnson and Johnson Pharmaceutical Research and Development, L.L.C., Raritan, NJ 08869, USA. bfoleno@prdus.jnj.com
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Foleno
authors.forename: Darren
authors.initials: D
authors.lastname: Abbanat
authors.forename: Raul M
authors.initials: RM
authors.lastname: Goldschmidt
authors.forename: Robert K
authors.initials: RK
authors.lastname: Flamm
authors.forename: Steve D
authors.initials: SD
authors.lastname: Paget
authors.forename: Glenda C
authors.initials: GC
authors.lastname: Webb
authors.forename: Ellyn
authors.initials: E
authors.lastname: Wira
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Macielag
authors.forename: Karen
authors.initials: K
authors.lastname: Bush
mesh_terms: D000081:Acetamides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D016983:Enterococcus / Q000187:drug effects; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; C518323:RWJ-416457; D000069349:Linezolid