Recurrence of dilated cardiomyopathy after re-introduction of a tricyclic antidepressant.
A causal relationship between treatment with tricyclic antidepressant (TCA) at therapeutic doses and cases of dilated cardiomyopathy has been suspected, but not definitely evidenced. We present a case of a dilated cardiomyopathy, which seemed idiopathic, but occurred during treatment with imipramine and recovered after its withdrawal. For the first recorded time, the cardiomyopathy recurred 9 years later, after a 2-year period of treatment with amitriptyline and lithium, and recovered again 1 year after both psychotropic drugs withdrawal. New arguments for the existence of TCA-induced dilated cardiomyopathy are brought.
Briec
F
F
Clinique cardiologique et des maladies vasculaires. Institut du thorax, CHU, 44093 Nantes.
Delaire
C
C
Bouhour
J B
JB
Trochu
J N
JN
D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000009:adverse effects*; D008875:Middle Aged; D012008:Recurrence
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine