title: A P300 event related potential technique for assessment of sexually oriented interest.
abstract: OBJECTIVE
  Despite all of the modern, sophisticated tests that exist for diagnosing and assessing male and female sexual disorders, to our knowledge there is no objective psychophysiological test to evaluate sexual arousal and interest. We provide preliminary data showing a decrease in auditory P300 wave amplitude during exposure to sexually explicit video clips and a significant correlation between the auditory P300 amplitude decrease and self-reported scores of sexual arousal and interest in the clips.
  
  
  METHODS
  A total of 30 healthy subjects were exposed to several blocks of auditory stimuli administered using an oddball paradigm. Baseline auditory P300 amplitudes were obtained and auditory stimuli were then delivered while viewing visual clips with 3 types of content, including sport, scenery and sex.
  
  
  RESULTS
  Auditory P300 amplitude significantly decreased during viewing clips of all contents. Viewing sexual content clips caused a maximal decrease in P300 amplitude (p <0.0001). In addition, a high correlation was found between the amplitude decrease and scores on the sexual arousal questionnaire regarding the viewed clips (r = 0.61, p <0.001). In addition, the P300 amplitude decrease was significantly related to the sexual interest score (r = 0.37, p = 0.042) but not to interest in clips of nonsexual content.
  
  
  CONCLUSIONS
  The change in auditory P300 amplitude during exposure to visual stimuli with sexual context seems to be an objective measure of subject sexual interest. This method might be applied to assess therapeutic intervention and as a diagnostic tool for assessing disorders of impaired libido or psychogenic sexual dysfunction.
authors.affiliation: Neuro-urology Unit, Technion Faculty of Medicine, Rambam Medical Center, Haifa, Israel. yvardi@rambam.health.gov.il
authors.forename: Yoram
authors.initials: Y
authors.lastname: Vardi
authors.forename: Michal
authors.initials: M
authors.lastname: Volos
authors.forename: Elliot
authors.initials: E
authors.lastname: Sprecher
authors.forename: Yelena
authors.initials: Y
authors.lastname: Granovsky
authors.forename: Ilan
authors.initials: I
authors.lastname: Gruenwald
authors.forename: David
authors.initials: D
authors.lastname: Yarnitsky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020018:Sexual Dysfunctions, Psychological / Q000175:diagnosis / Q000503:physiopathology*