Dermatomyositis as a paraneoplastic syndrome in carcinosarcoma of uterine origin.
Paraneoplastic syndromes are a collection of disorders affecting an organ or tissue caused by cancer but occurring at a site distant from the primary or metastases. Dermatomyositis can occur in association with malignancy as a paraneoplastic phenomenon. We present a case of a patient presenting simultaneously with an advanced carcinosarcoma of the uterus and dermatomyositis. The diagnoses, pathophysiology and treatment of these two conditions are discussed and current published studies reviewed.
Chandiramani
M
M
Department of Women's Health, St. Thomas' Hospital, London, UK. mchandir@hotmail.com
Joynson
C
C
Panchal
R
R
Symonds
R P
RP
Brown
L J R
LJ
Morgan
B
B
Decatris
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002296:Carcinosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003882:Dermatomyositis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D010388:Pelvis / Q000000981:diagnostic imaging; D011859:Radiography; D014594:Uterine Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery
D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin