title: Preparation, characterization and controlled release investigation of interpenetrating polymer networks of poly(acrylic acid)/triazole modified poly(vinyl alcohol).
abstract: A series of interpenetrating polymer networks of poly(acrylic acid) (PAA)/triazole modified poly(vinyl alcohol) (TMIPNs) were synthesized by radical polymerization in methanol at room temperature with l-ascorbic acid (Vc) and peroxide hydrogen (H2O2) as initiators and trihydroxymethyl propane glycidol ether (6360) as a crosslinker. The structures of the gels were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The swelling/deswelling behavior of hydrogels was studied in different pH and different concentrations of NaCl aqueous solutions. The results showed that the TMIPNs hydrogels had excellent pH- and salt-sensitivity in the range of the investigation. The mechanism of the swelling and the deswelling was discussed and the results were confirmed further by scanning electron microscope (SEM). In addition, the controlled release behavior of TMIPNs in vitro was also studied. The effects of physical stimulus (ultraviolet ray and ultrasonic wave), salt concentration, pH value and the swelling/deswelling on the controlled released behavior were also explored.
authors.affiliation: Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Liu
authors.forename: Zhenbin
authors.initials: Z
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Liang
authors.forename: Shenglong
authors.initials: S
authors.lastname: Ding
authors.forename: Shilan
authors.initials: S
authors.lastname: Chen
authors.forename: Shuping
authors.initials: S
authors.lastname: Jin
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D044366:Transition Temperature; D014230:Triazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D020100:Hydrogels; D014230:Triazoles; D014867:Water; D012965:Sodium Chloride; C006903:carbopol 940; D011142:Polyvinyl Alcohol