[Process of complexation of prothrombine and fibrin E-fragment].
The study is devoted to research of the blood coagulation key proenzyme complexation process. It is prothrombin, and the E-fragment of fibrin can be a component in blood circulation. It is shown, that non-enzyme activation of prothrombin by the E-fragment proceeds as a result of formation of stable non-covalent prothrombin-E fragment complex. The cringle structures of prothrombin and the N-terminal site of beta-chain of E-fragment of fibrin are important for formation of the given complex. It has been defined, that other fragments of fibrin (D and DD) are not capable to induce amydolytic activity of prothrombin.
Savchuk
O M
OM
Krasnobryzha
Ie M
IeM
Horchev
V F
VF
Chernyshenko
T M
TM
Havryliuk
S P
SP
Platonova
T M
TM
D001777:Blood Coagulation / Q000502:physiology; D015153:Blotting, Western; D002850:Chromatography, Gel; D005338:Fibrin Fibrinogen Degradation Products / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D011516:Prothrombin / Q000737:chemistry* / Q000502:physiology
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; C072054:fibrin fragment E-2; D011516:Prothrombin