title: How closely is Helicobacter pylori infection related to gastroduodenal lesions?
abstract: OBJECTIVE
  Various studies have indicated a relationship between Helicobacter pylori infection and upper gastrointestinal lesions, but this relationship needs to be assessed in individuals not seeking medical treatment for complaints.
  
  
  METHODS
  We screened community residents for H. pylori infection and upper gastrointestinal lesions during an annual mass health examination aiming to determine relationships between infection and lesions. In 932 examinees we performed a 13C-urea breath test for H. pylori infection, and assessed degree of gastric atrophy by measuring pepsinogen I and II in serum. In 738 subjects we also performed upper gastrointestinal radiography with or without endoscopy.
  
  
  RESULTS
  Prevalence of H. pylori infection increased with age, and the ratio of serum pepsinogen I to II decreased with age. Prevalence of H. pylori infection did not differ significantly between subjects with and without radiographically or endoscopically evident lesions. Of H. pylori-positive subjects with peptic ulcer, 73.2% had no recurrence of ulcer despite absence of medical treatment.
  
  
  CONCLUSIONS
  Prolonged H. pylori infection was associated with atrophy of the gastric mucosa, but little relationship was evident between H. pylori infection and development or recurrence of peptic ulcer.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine II, Osaka Medical College, Japan. in2021@poh.osaka-med.ac.jp
authors.forename: Chikao
authors.initials: C
authors.lastname: Shimamoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hirata
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tokioka
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeuchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hiraike
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Katsu
mesh_terms: D000328:Adult; D001284:Atrophy; D001944:Breath Tests; D004381:Duodenal Ulcer / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005757:Gastritis, Atrophic / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D020116:Pepsinogen A / Q000097:blood; D020115:Pepsinogen C / Q000097:blood; D013276:Stomach Ulcer / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D020115:Pepsinogen C; D020116:Pepsinogen A