[Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood].
OBJECTIVE
A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS).


METHODS
The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode.


RESULTS
The linear range was 0.1-10 microg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 microg/mL.


CONCLUSIONS
The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology.
Zhu
You-Jiang
YJ
The people's Procuratorate of Huzhou, Huzhou 313000, China.
Ding
Xuan-Kun
XK
D018686:Anesthetics, Intravenous / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D015742:Propofol / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D018686:Anesthetics, Intravenous; D015742:Propofol