[Pathological characteristics of diabetic macro-angiopathy].
The pathological features of coronary diabetic macro-angiopathy were characterized by the acceleration of atherosclerotic lesions. Among the Hisayama cohort study subjected for participants in the screening examination in 1988, the coronary atherosclerotic grade, pathologically estimated on luminal stenosis and/or incidence of advanced lesions of coronary arteries, was significantly correlated with serum HbA1c, levels. These findings suggest that the impaired glucose metabolism is a significant risk factor for coronary atherosclerosis in Japan. The clinico-pathological survey of risk factors for atherosclerosis in the general Japanese population would be very important in not only the further clarification of Japanese atherogenesis but also the exploration and development of novel diagnostic and therapeutic strategies, and preventive guidelines for atherosclerosis-related cardiovascular diseases in Japan nowadays under the remarkable changes of life-style.
Sueishi
Katsuo
K
Division of Pathophysiology and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University.
Sumiyoshi
Shinji
S
Nakashima
Yutaka
Y
D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D018149:Glucose Intolerance / Q000150:complications; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D012307:Risk Factors