title: The interrupter technique to assess airway responsiveness in children with cystic fibrosis.
abstract: The aim of this study was to assess the validity of the interrupter technique (Rint) in measuring airway responsiveness in children with cystic fibrosis. Fifty children (aged 6-16 years) with cystic fibrosis performed six Rint measurements followed by three acceptable forced expiratory maneuvers. Each child then inhaled 5 mg of nebulized salbutamol by facemask. After 20 min the Rint and forced expiratory measurements were repeated. In the population as a whole a moderate but significant correlation between inverse Rint and FEV1 values was observed, both before and after inhaled bronchodilator (r=0.71 and 0.72, respectively, P < 0.001). However, when changes in Rint and FEV1 readings following inhaled bronchodilator were examined, no relationship was seen. Indeed, the two methods identified completely different subsets of children as being bronchodilator responsive. These results indicate that although a relationship exists between Rint and FEV1 in the whole population, this is not the case in individual children. Rint and FEV1 reflect different aspects of lung function. It is not appropriate to use Rint as a simple alternative for FEV1 in children with cystic fibrosis when assessing airway responsiveness.
authors.affiliation: Department of Respiratory Paediatrics, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, UK. daviep@doctors.net.uk
authors.forename: Philip L
authors.initials: PL
authors.lastname: Davies
authors.forename: Iolo J
authors.initials: IJ
authors.lastname: Doull
authors.forename: Frances
authors.initials: F
authors.lastname: Child
mesh_terms: D000293:Adolescent; D000403:Airway Resistance / Q000187:drug effects*; D000420:Albuterol / Q000008:administration & dosage; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000379:methods*; D013147:Spirometry
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol