title: Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves.
abstract: Ninety, seven- to 10-day-old calves were allocated to three groups of 30 and treated daily for seven days with either 100 microg/kg halofuginone hydrobromide or 2.5 mg/kg decoquinate orally or left untreated as controls. The levels of diarrhoea and dehydration were monitored daily for 28 days from the first day of treatment (day 0) and samples of faeces were collected on days 0, 7, 14, 21 and 28, to quantify the excretion of Cryptosporidium parvum oocysts. The calves were weighed on days 3 and 28. The treatments had no effect on the levels of diarrhoea or dehydration, the proportions of diarrhoeic calves or the proportions of calves shedding oocysts. However, unlike decoquinate, halofuginone significantly reduced the excretion of oocysts on day 7 (P<0.0001), and decoquinate increased the average daily weight gain of the calves (P=0.049).
authors.affiliation: Centre Hospitalier Universitaire Vétérinaire de St-Hyacinthe, 3200 Rue Sicotte, St-Hyacinthe, Québec J25 7C6, SC, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Lallemand
authors.forename: A
authors.initials: A
authors.lastname: Villeneuve
authors.forename: J
authors.initials: J
authors.lastname: Belda
authors.forename: P
authors.initials: P
authors.lastname: Dubreuil
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003049:Coccidiostats / Q000627:therapeutic use*; D003457:Cryptosporidiosis / Q000188:drug therapy / Q000662:veterinary*; D016785:Cryptosporidium parvum / Q000187:drug effects* / Q000302:isolation & purification; D003667:Decoquinate / Q000627:therapeutic use*; D003681:Dehydration / Q000188:drug therapy / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary; D003967:Diarrhea / Q000188:drug therapy / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary; D005243:Feces / Q000469:parasitology; D005260:Female; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D010880:Piperidines / Q000627:therapeutic use*; D052999:Quinazolinones / Q000627:therapeutic use*; D011897:Random Allocation; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D003049:Coccidiostats; D010880:Piperidines; D052999:Quinazolinones; D003667:Decoquinate; C010176:halofuginone