Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients.
Magnetometry analysis of brain tissue sub-samples from two neuroferritinopathy patients provides a preliminary indication that the amount of magnetic iron compounds associated with this rare disease is significantly larger than in age/sex-matched controls. The primary iron compounds contributing to the remnant magnetization of the tissue above 50 K and at body temperature are both blocked and superparamagnetic (SPM) biogenic magnetite (Fe3O4) and/or maghemite (gamma-Fe2O3). The concentration of SPM magnetite is significant and appears to be proportional to the concentration of ferritin, which varies with progression of the disease. The mutated ferritin protein appears to be responsible for the presence of iron oxide nano-particules, which in turn could be responsible for extensive damage in the brain.
Hautot
Dimitri
D
Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, and Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK. dimitri@biomagnetism.co.uk
Pankhurst
Quentin A
QA
Morris
Chris M
CM
Curtis
Andrew
A
Burn
John
J
Dobson
Jon
J
D000368:Aged; D001479:Basal Ganglia / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005290:Ferric Compounds / Q000032:analysis / Q000378:metabolism*; D005293:Ferritins / Q000235:genetics*; D052203:Ferrosoferric Oxide / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles / Q000032:analysis; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism*; D035583:Rare Diseases; D013696:Temperature
D005290:Ferric Compounds; C000499:ferric oxide; D005293:Ferritins; D052203:Ferrosoferric Oxide