title: Particulate systems as adjuvants and carriers for peptide and protein antigens.
abstract: The most common feature for antigen-delivery systems is their particulate nature. Together with a certain depot effect, it is the particulate nature that primarily dictates whether the antigen-delivery system will be successful in inducing a certain type and strength of immune response. In this article, we will summarize recent data on particulate delivery systems for peptide and protein antigens with a main focus on lipid or polymer-based particles, all of which possess high potential as both preventive and therapeutic vaccines for parenteral, nasal, and possibly oral administration.
authors.affiliation: School of Pharmacy, University of Queensland, Australia.
authors.forename: Ming Tao
authors.initials: MT
authors.lastname: Liang
authors.forename: Nigel M
authors.initials: NM
authors.lastname: Davies
authors.forename: Joanne T
authors.initials: JT
authors.lastname: Blanchfield
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000737:chemistry*; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D016882:ISCOMs; D008081:Liposomes; D010316:Particle Size; D010455:Peptides / Q000008:administration & dosage*; D014614:Vaccines, Synthetic / Q000008:administration & dosage*
chemical_list: D000277:Adjuvants, Pharmaceutic; D000941:Antigens; D004337:Drug Carriers; D016882:ISCOMs; D008081:Liposomes; D010455:Peptides; D014614:Vaccines, Synthetic