title: [Blue discoloration of hands, numbness of feet, indolent cervical lymph node swelling in a 73-year-old man].
abstract: A 73-years old patient came to our outpatient clinic because of a blue discoloration of his hands. Furthermore there was a systemic inflammatory reaction, burning pain and numbness of his feet due to a polyneuropathy, and an indolent enlargement of the cervical lymph nodes. In 1996 and 2001 cervical lymph node resections were done because of localized angiofollicular lymphnode hyperplasia (Castleman's disease). The laboratory values confirmed a systemic inflammatory reaction, a hypothyreosis and a monoclonal gammopathy. A CT-scan showed enlarged cervical, intrathoracic and abdominal lymphnodes and a splenomegaly. So all the criterias for a POEMS syndrome (special form of multiple myeloma) were met with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes. The generalized lymphadenopathy corresponded histologically to the prior mentioned Castleman's disease. The patient responded well to systemic glucocorticoid treatment and today he is asymptomatic.
authors.affiliation: Medizinische Poliklinik, Departement für Innere Medizin, Universitätsspital Zürich.
authors.forename: C
authors.initials: C
authors.lastname: Kurzen
authors.forename: I
authors.initials: I
authors.lastname: Kunz
authors.forename: C
authors.initials: C
authors.lastname: Nigg
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D005528:Foot / Q000294:innervation*; D006229:Hand Dermatoses / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy / Q000209:etiology*; D006987:Hypesthesia / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D009333:Neck; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence
chemical_list: D011241:Prednisone