title: Assessing the burden of influenza and other respiratory infections in England and Wales.
abstract: OBJECTIVE
  To estimate the burden of influenza in England and Wales, in terms of general practice consultations, hospital admissions and deaths.
  
  
  METHODS
  Multivariable regression was used to estimate the influenza attributable fraction of general practice consultations recorded in the general practice research database, of hospital admissions from hospital episode statistics and of deaths recorded by the Office of National Statistics.
  
  
  RESULTS
  An estimated 779,000 (95%CI+/-258,000)-1,164,000 (95%CI+/-425,000) general practice consultations, 19,000 (95%CI+/-5000)-31,200 (95%CI+/-11,000) hospital admissions and 18,500 (95%CI 2500)-24,800 (95%CI+/-2500) deaths annually are attributable to influenza infections. In primary care, the bulk of the burden falls on those under the age of 45, whereas the elderly are more likely to be hospitalised and to die.
  
  
  CONCLUSIONS
  Although there are significant uncertainties, and considerable year on year variations, it is clear that the burden of influenza is considerable. Although much of this burden falls on the elderly, significant numbers of general practice consultations, hospitalisations and even some deaths occur annually in children in England and Wales.
authors.affiliation: Statistics, Modelling and Bioinformatics Department, Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK. richard.pitman@hpa.org.uk <richard.pitman@hpa.org.uk>
authors.forename: R J
authors.initials: RJ
authors.lastname: Pitman
authors.forename: A
authors.initials: A
authors.lastname: Melegaro
authors.forename: D
authors.initials: D
authors.lastname: Gelb
authors.forename: M R
authors.initials: MR
authors.lastname: Siddiqui
authors.forename: N J
authors.initials: NJ
authors.lastname: Gay
authors.forename: W J
authors.initials: WJ
authors.lastname: Edmunds
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007251:Influenza, Human / Q000453:epidemiology* / Q000401:mortality; D008875:Middle Aged; D010343:Patient Admission / Q000706:statistics & numerical data; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000401:mortality; D014852:Wales / Q000453:epidemiology