Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression.
Experiment 1 examined the effects of electrical stimulation of nucleus basalis magnocellularis (NBM) on a relational odor-association task--the social transmission of food preference (STFP). Rats were stimulated unilaterally in the NBM for 20 min (100 microA, 1 Hz) immediately before the social training. They were tested on their ability to remember preference for the trained food either immediately or following a 24-h delay. Stimulation of NBM improved retention regardless of delay, and additional behavioral measures (social interaction, motor activity, or exploration) did not account for such effects. Experiment 2 investigated brain regions activated after NBM electrical stimulation by examining the induction of c-Fos. This treatment led to bilateral increased c-Fos expression in prefrontal regions, such as orbitofrontal, prelimbic, and infralimbic cortices, and some hippocampal subregions (dorsal CA and ventral dentate gyrus). In contrast, no differences between groups in c-Fos expression were found in basolateral amygdala, dorsal dentate gyrus, ventral CA, or ventral subiculum. Present findings indicate that pretraining NBM electrical stimulation facilitates the acquisition of STFP, supporting a role of NBM in the early stages of memory formation, and suggest that the treatment might cause such effects by inducing neural changes, related to transcription factors such as c-Fos, in the prefrontal cortex or the hippocampal formation.
Boix-Trelis
Núria
N
Departament de Psicobiologia i Metodologia de les Ciències de la Salut Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona 08193, Spain.
Vale-Martínez
Anna
A
Guillazo-Blanch
Gemma
G
Costa-Miserachs
David
D
Martí-Nicolovius
Margarita
M
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D020532:Basal Nucleus of Meynert / Q000502:physiology*; D004558:Electric Stimulation; D005247:Feeding Behavior / Q000502:physiology*; D005518:Food Preferences / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism; D007100:Imitative Behavior / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology*; D017397:Prefrontal Cortex / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012903:Smell / Q000502:physiology; D012931:Social Environment
D016760:Proto-Oncogene Proteins c-fos