[Autoantibodies against alpha1 adrenergic receptor related with cardiac remodeling in hypertensive patients by clinical observation].
OBJECTIVE
To investigate the effects of autoantibodies against alpha(-) adrenergic receptor on cardiac remodeling in patients with hypertension.


METHODS
Five hundred and fifty three patients with hypertension in our hospital were selected. The autoantibodies against alpha(1) adrenergic receptor in sera of donor were detected by ELISA, and the results of echocardiography were recorded. By multiple logistic regressions, the risk factors were analyzed on left ventricular enlargement of hypertension.


RESULTS
The percentage of autoantibodies against alpha(1) adrenergic receptor positive was 32.3% (179/553). There were significant difference between the positive group and negative group on the ratio of left atrial enlargement (53.6%, 44.3%, respectively; P < 0.05) and left ventricular enlargement (12.8%, 6.1%, respectively; P < 0.01). The result of regression analysis demonstrated that 4 risk factors were related to left ventricular enlargement, including male, course of disease, heart rate (HR) and autoantibodies against alpha(1) adrenergic receptor in the serum (all P < 0.05).


CONCLUSIONS
The autoantibodies against alpha(1) adrenergic receptor have a relationship with left ventricular enlargement of hypertension. Patients with the activity of autoantibodies against alpha(1) adrenergic might contribute to predict cardiac remodeling.
Li
Zheng-zai
ZZ
Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science Technology, Wuhan 430022, China.
Liao
Yu-hua
YH
Zhou
Zi-hua
ZH
Wei
Yu-miao
YM
Wang
Min
M
Zhu
Feng
F
Chen
Ming
M
Du
Xiong-bing
XB
Sun
Yan-xiang
YX
Zhang
Hai-yan
HY
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000276:immunology / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018340:Receptors, Adrenergic, alpha-1 / Q000276:immunology*; D020257:Ventricular Remodeling / Q000276:immunology
D001323:Autoantibodies; D018340:Receptors, Adrenergic, alpha-1