Expression of NF-kappaB in Helicobacter pylori infection.
Helicobacter pylori colonizes the gastric mucosa in humans and causes chronic gastritis. NF-kappaB has a key role as a mediator in mucosal inflammation. In this study, we examined the expression of NF-kappaB in the antral epithelial cells of H. pylori-infected and H. pylori-uninfected biopsies and examined these processes in relationship with grade and activity of gastritis, density of H. pylori, presence of the intestinal metaplasia, and atrophy. Fifty biopsies (35 H. pylori-positive patients and 15 H. pylori-negative controls) were studied. NF-kappaB immunohistochemical stain was performed. NF-kappaB activity in H. pylori-infected biopsies were markedly enhanced compared with uninflamed biopsies (P = 0.001). We also found positive correlation NF-kappaB expression with severity of gastritis (according to Sydney score) (P = 0.001), activity of gastritis (P = 0.046) and H. pylori load (P < 0.001), and atrophy (P = 0.004). We did not find a significant relationship between NF-kappaB and the presence of intestinal metaplasia (P = 0.355). These findings suggested that expression of NF-kappaB has an important role in H. pylori gastritis.
Doger
Furuzan Kacar
FK
Department of Pathology, Adnan Menderes Universty School of Medicine, Aydin, Turkey. fdoger@adu.edu.tr
Meteoglu
Ibrahim
I
Ozkara
Esra
E
Erkul
Zehra Kocakaya
ZK
Okyay
Pinar
P
Yükselen
Vahit
V
D001284:Atrophy / Q000473:pathology; D001706:Biopsy; D004847:Epithelial Cells / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D015964:Gene Expression Regulation, Bacterial; D016481:Helicobacter Infections / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008679:Metaplasia / Q000473:pathology; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies; D012720:Severity of Illness Index
D016328:NF-kappa B