title: Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors.
abstract: The objective was to describe the prevalence and factors associated with uterine cervical cancer (CA) and high-grade squamous intraepithelial lesions (HSIL) in adolescents. A cross-sectional study was carried out with 702 sexually active adolescents treated at a general hospital in Rio de Janeiro, Brazil, from 1993 to 2002. Screening was performed by cytopathology and colposcopy and confirmation by biopsy. Exposure variables were socio-demographic characteristics and those related to reproductive health, habits, and sexual behavior. Adjusted odds ratios were estimated using multivariate logistic regression analysis. Based on histopathology, the prevalence of HSIL/CA was 3% (95%CI: 1.8-4.6). There was one case of invasive cancer. With each additional pregnancy, the odds of HSIL/CA increased by 2.2 (95%CI: 1.1-4.4). Age was also associated with this outcome, doubling the odds of acquiring this degree of disease with each year of age (OR = 2.0; 95%CI: 1.2-3.4). The prevalence of lesions suggests the importance of including sexually active adolescent females in cervical cancer screening programs aimed at early detection and treatment of these lesions.
authors.affiliation: Instituto Fernandes Figueira, Fundação, Rio de Janeiro, Brasil. denimonteiro2@yahoo.com.br
authors.forename: Denise Leite Maia
authors.initials: DL
authors.lastname: Monteiro
authors.forename: Alexandre José Baptista
authors.initials: AJ
authors.lastname: Trajano
authors.forename: Kátia Silveira
authors.initials: KS
authors.lastname: da Silva
authors.forename: Fábio Bastos
authors.initials: FB
authors.lastname: Russomano
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D010298:Parity; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000473:pathology; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology