title: Isolation and identification of the icosalides--cyclic peptolides with selective antibiotic and cytotoxic activities.
abstract: Three cyclic peptolides have been isolated from two different fungal species and their structures determined. Icosalides A1 (1a), A2 (1b), and B (1c) each contain two serine and two leucine amino acid residues and incorporate two fatty acid moieties as part of the central twenty-member ring. 1a contains L-serine and both D- and L-leucine residues, while 1b and 1c contain only L-amino acid residues. Icosalide A1 displays antimicrobial activity against Streptococcus pyogenes, S. pneumoniae (Felton), and Enterococcus faecalis. Icosalides A2 and B are cytotoxic to replicating MDCK cells.
authors.affiliation: MYCOsearch, OSI Pharmaceuticals, 4905 Pine Cone Drive, Durham, North Carolina 27707, USA. cboros@mycosynthetix.com
authors.forename: Christie
authors.initials: C
authors.lastname: Boros
authors.forename: Cameron J
authors.initials: CJ
authors.lastname: Smith
authors.forename: Yelena
authors.initials: Y
authors.lastname: Vasina
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
authors.forename: Alissa B
authors.initials: AB
authors.lastname: Dix
authors.forename: Blaise
authors.initials: B
authors.lastname: Darveaux
authors.forename: Cedric
authors.initials: C
authors.lastname: Pearce
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000187:drug effects; D047630:Depsipeptides; D055666:Lipopeptides
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D010456:Peptides, Cyclic; C515291:Icosalide A1; D047630:Depsipeptides; D055666:Lipopeptides; C515290:Icosalide A2; C515292:Icosalide B