Treatment of ocular squamous cell carcinomas in cattle with interleukin-2.
In total, 174 bovine ocular squamous cell carcinomas of varying sizes (20 to 2800 mm(2) in area) were treated daily with peritumoural injections of solvent, or solvent containing 5000 U, 20,000 U, 200,000 U, 500,000 U, 1 million U or 2 million U interleukin-2 (IL-2) for 10 days. The tumours were measured and clinically staged before treatment and at one, three, four, nine and 20 months after treatment. After 20 months, 14 per cent of the tumours treated with the solvent had regressed completely, a significantly smaller proportion than the 55 per cent treated with 5000 U IL-2, 52 per cent treated with 20,000 U IL-2, 58 per cent treated with 200,000 U IL-2, 50 per cent treated with 500,000 U IL-2, 69 per cent of tumours treated with 1 million U IL-2, 52 per cent treated with 2 million U IL-2. The tumours on the third eyelid and limbus were the most responsive.
Stewart
R J E
RJ
Faculty of Veterinary Science, University of Zimbabwe, PO Box MP167, Mount Pleasant, Harare, Zimbabwe.
Hill
F W G
FW
Masztalerz
A
A
Jacobs
J J L
JJ
Koten
J W
JW
Den Otter
W
W
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005134:Eye Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D007376:Interleukin-2 / Q000627:therapeutic use*; D016896:Treatment Outcome; D015030:Zimbabwe
D000970:Antineoplastic Agents; D007376:Interleukin-2