title: Use of platelet-rich plasma under autogenous onlay bone grafts.
abstract: OBJECTIVE
  To analyze the healing of autogenous onlay bone grafts in three different situations, focusing on the interface area.
  
  
  METHODS
  Sixteen rabbits underwent autogenous bone graft surgeries in the calvaria. The block bone grafts were positioned in three different situations: direct contact between bone graft and receptor bed, graft interposed by particulate bone, and graft interposed by platelet-rich plasma (PRP). After 7, 15, 30, and 60 days, the specimens were retrieved for histological and morphometric evaluation.
  
  
  RESULTS
  All groups healed uneventfully and presented incorporation of the grafts after 30 days. A slightly more evident new bone formation could be observed in the PRP group in the first analyzed period, and an earlier maturation of bone in the last period, although no statistically significant differences were achieved.
  
  
  CONCLUSIONS
  The use of additional material between the bone graft and the receptor bed when using the onlay technique must be carefully considered, taking into account the size of the reconstruction and the cost/benefit relation. The addition of PRP in between autogenous bone blocks and the receptor bed did not confer significant benefit for the new bone formation and healing on the calvaria of bone of rabbits.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Universidade do Sagrado Coração - USC, Bauru, São Paulo, Brazil.
authors.forename: Sandra Regina
authors.initials: SR
authors.lastname: Miranda
authors.forename: Hugo
authors.initials: H
authors.lastname: Nary Filho
authors.forename: Luís Eduardo Marques
authors.initials: LE
authors.lastname: Padovan
authors.forename: Daniel Araki
authors.initials: DA
authors.lastname: Ribeiro
authors.forename: Daniela
authors.initials: D
authors.lastname: Nicolielo
authors.forename: Mariza Akemi
authors.initials: MA
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D006097:Granulation Tissue / Q000033:anatomy & histology; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D010294:Parietal Bone / Q000033:anatomy & histology / Q000601:surgery; D053657:Platelet-Rich Plasma; D011817:Rabbits; D012886:Skull / Q000033:anatomy & histology / Q000601:surgery*; D013977:Tibia / Q000637:transplantation*