title: An open trial of light therapy in adult attention-deficit/hyperactivity disorder.
abstract: OBJECTIVE
  In adults with attention-deficit/ hyperactivity disorder (ADHD), a delayed sleep/ activity rhythm and/or seasonal mood symptoms may contribute significantly to core pathology and disability. This study examined whether a chronobiologically based treatment, i.e., morning bright light therapy (LT), might have utility as an adjunctive treatment for adult ADHD in the fall/ winter period.
  
  
  METHODS
  Twenty-nine adults with DSM-IV ADHD were administered a standard 3-week open trial of LT during the fall or winter months. Primary outcome measures included percentage reduction on the Brown Adult ADD Scale and the Conners' Adult ADHD Scale. Secondary measures were decrease in depression scores according to the Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorder version; improvements on various neuropsychological tests; and shift toward an earlier circadian preference as measured by the Horne-Ostberg Morningness-Eveningness questionnaire. Regression analyses determined which variables at baseline best predicted improvement on a given outcome measure and which variables changed in parallel with one another. The study was conducted from November 2003 through February 2004.
  
  
  RESULTS
  Morning bright light therapy was associated with a significant decrease in both subjective and objective measures of core ADHD pathology, improved mood symptoms, and a significant phase advance in circadian preference. Multiple regression showed that the shift toward an earlier circadian preference with LT was the strongest predictor of improvement on both subjective and objective ADHD measures. Neither baseline global seasonality scores nor baseline depression scores strongly predicted LT effects on most measures of ADHD.
  
  
  CONCLUSIONS
  These findings suggest that during the fall/winter period, LT may be a useful adjunct in many adults with ADHD. Strikingly, the strongest correlate of improvement in core ADHD pathology was a phase advance in circadian preference rather than alleviation of comorbid seasonal affective disorder, suggesting important clinical benefits of LT beyond the treatment of seasonal affective disorder.
authors.affiliation: Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. irybak@uwo.ca
authors.forename: Yuri E
authors.initials: YE
authors.lastname: Rybak
authors.forename: Heather E
authors.initials: HE
authors.lastname: McNeely
authors.forename: Bronwyn E
authors.initials: BE
authors.lastname: Mackenzie
authors.forename: Umesh R
authors.initials: UR
authors.lastname: Jain
authors.forename: Robert D
authors.initials: RD
authors.lastname: Levitan
mesh_terms: D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002940:Circadian Rhythm; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017060:Patient Satisfaction; D010789:Phototherapy / Q000379:methods*; D012044:Regression Analysis; D016574:Seasonal Affective Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D012621:Seasons; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants