title: Finite element-based probabilistic analysis tool for orthopaedic applications.
abstract: Orthopaedic implants, as well as other physical systems, contain inherent variability in geometry, material properties, component alignment, and loading conditions. While complex, deterministic finite element (FE) models do not account for the potential impact of variability on performance, probabilistic studies have typically predicted behavior from simplified FE models to achieve practical solution times. The objective of this research was to develop an efficient and versatile probabilistic FE tool to quantify the effect of uncertainty in the design variables on the performance of orthopaedic components under relevant conditions. Key aspects of the computational tool developed include parametric and automated FE model creation for changes in dimensional variables, efficient solution using the advanced mean-value (AMV) reliability method, and identification of the most significant design variables. Two orthopaedic applications are presented to demonstrate the ability of the computational tool to efficiently and accurately represent component performance.
authors.affiliation: University of Denver, Computational Biomechanics Lab, 2390 S. York, Denver, CO 80208, United States.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Easley
authors.forename: Saikat
authors.initials: S
authors.lastname: Pal
authors.forename: Paul R
authors.initials: PR
authors.lastname: Tomaszewski
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Petrella
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Rullkoetter
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Laz
mesh_terms: D020342:Finite Element Analysis; D008962:Models, Theoretical; D009985:Orthopedics; D011336:Probability; D012680:Sensitivity and Specificity