Oxidative amide synthesis and N-terminal alpha-amino group ligation of peptides in aqueous medium.
A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal alpha-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.
Chan
Wing-Kei
WK
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Ho
Chi-Ming
CM
Wong
Man-Kin
MK
Che
Chi-Ming
CM
D010084:Oxidation-Reduction; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
D010455:Peptides; D014867:Water