title: Non-steroidal anti-inflammatory drugs and the risk of psychosis.
abstract: The objective of the current research was to examine the relation between non-steroidal anti-inflammatory drugs (NSAID) use and risk of psychosis. To this end we performed a longitudinal case-control study using prescription data from a Dutch health insurance company. Men aged 25 years or over and women aged 30 years or over were excluded to prevent inclusion of non-incident cases. This resulted in eighty-two cases and 359 randomly selected controls from the same population. The overall relative risk of incident antipsychotic use for NSAID users, adjusted for age and prescription frequency, was 0.80 (95% CI: 0.48-1.33). After stratification for gender the risk of psychosis was significantly lower (59%) in male NSAID users only. The relative risks for male and female subjects were 0.41 (95% CI: 0.17-0.97) and 1.31 (95% CI: 0.65-2.64), respectively. These results suggest that in men NSAIDs may lower the risk of psychosis.
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. W.Laan@umcutrecht.nl
authors.forename: W
authors.initials: W
authors.lastname: Laan
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Selten
authors.forename: D E
authors.initials: DE
authors.lastname: Grobbee
authors.forename: H
authors.initials: H
authors.lastname: Smeets
authors.forename: René S
authors.initials: RS
authors.lastname: Kahn
authors.forename: Huibert
authors.initials: H
authors.lastname: Burger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012306:Risk; D012737:Sex Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal