Discovering orphans' sweet secret: NR4A receptors and hepatic glucose production.
Aberrant hepatic gluconeogenesis contributes importantly to hyperglycemia in type II diabetic patients. A study by Pei et al. (2006b) identifies NR4A orphan nuclear receptors as a novel branch of cAMP-dependent regulators of hepatic glucose production under healthy and diabetic conditions.
Berriel Diaz
Mauricio
M
Emmy-Noether Research Group, Molecular Metabolic Control A170, German Cancer Research Center Heidelberg, 69120 Heidelberg, Germany.
Lemke
Ulrike
U
Herzig
Stephan
S
D004268:DNA-Binding Proteins / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005947:Glucose / Q000096:biosynthesis*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; C539821:NR4A1 protein, human; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; D005947:Glucose