title: Effects of breed, gender, exercise and white-coat effect on markers of endothelial function in dogs.
abstract: This study examines how systemic biomarkers of endothelial function and nitric oxide metabolism are affected by exercise in dogs. Furthermore, breed variation and white-coat effect have been tested by sampling three different dog breeds both in their home and in a clinical setting. Short-term exercise increased plasma nitrate and nitrite (NOx) and von Willebrand factor (vWf). There was significant difference between Pointers and the small dog breeds Cairn Terriers and Cavalier King Charles Spaniels in the general plasma levels of vWf and asymmetric dimethylarginine (ADMA). NOx and vWf were significantly higher when the sample was taken in the laboratory cf. at home, whereas ADMA and L-arginine were significantly lower. In conclusion, both short-term exercise and white-coat effect influence several plasma markers of endothelial function depending also on the breed and gender of the dogs. These findings should be considered in future studies concerning endothelial function in dogs.
authors.affiliation: Department of Basic Animal and Veterinary Sciences, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, Frederiksberg C DK-1870, Denmark. som@kvl.dk
authors.forename: S G
authors.initials: SG
authors.lastname: Moesgaard
authors.forename: A V
authors.initials: AV
authors.lastname: Holte
authors.forename: T
authors.initials: T
authors.lastname: Mogensen
authors.forename: J
authors.initials: J
authors.lastname: Mølbak
authors.forename: A T
authors.initials: AT
authors.lastname: Kristensen
authors.forename: A L
authors.initials: AL
authors.lastname: Jensen
authors.forename: T
authors.initials: T
authors.lastname: Teerlink
authors.forename: A J
authors.initials: AJ
authors.lastname: Reynolds
authors.forename: L H
authors.initials: LH
authors.lastname: Olsen
mesh_terms: D000413:Alaska; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers; D003116:Color; D004285:Dogs / Q000145:classification* / Q000235:genetics / Q000502:physiology*; D004727:Endothelium / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000097:blood; D005260:Female; D005786:Gene Expression Regulation; D006197:Hair; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012727:Sex Characteristics; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D015415:Biomarkers; D004791:Enzyme Inhibitors; D014841:von Willebrand Factor; D009569:Nitric Oxide; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine