title: Prognostic role of right ventricular dilatation and troponin I elevation in acute pulmonary embolism.
abstract: Acute pulmonary embolism continues to cause significant morbidity and mortality despite advances in diagnosis and treatment. This retrospective analysis aimed to determine whether the combination of elevated troponin I and right ventricular dilatation (RVD) could provide a more powerful predictor for risk evaluation. The study data comprised records of 110 patients with either high-probability ventilation/perfusion lung scan or positive spiral computed tomography. All cause 100-day mortality was 18.2%. The hypotension and RVD variables significantly influenced 100-day mortality. For the combination of RVD and raised troponin I, the 100-day mortality rate was 31%. Notably, the group with elevated troponin I and no RVD had a 100-day mortality rate of only 3.7%. The combination of RVD and elevated troponin had a positive predictive value of 31% and a negative predictive value of 88% for 100-day mortality. Compared with existing reports, conflicting conclusions for the individual prognostic role of elevated troponin I, cancer, and heart failure were obtained. These conflicting conclusions most likely resulted from inappropriate cut-off troponin I values and the modest sample size. In conclusion, the combination of elevated troponin and RVD was able to identify a subset of patients most likely to benefit from aggressive therapy.
authors.affiliation: Division of Cardiology, Chiayi Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Chai Yi Hsien, Taiwan.
authors.forename: Jen Te
authors.initials: JT
authors.lastname: Hsu
authors.forename: Chi Ming
authors.initials: CM
authors.lastname: Chu
authors.forename: Shih Tai
authors.initials: ST
authors.lastname: Chang
authors.forename: Hui Wen
authors.initials: HW
authors.lastname: Cheng
authors.forename: Nye Jan
authors.initials: NJ
authors.lastname: Cheng
authors.forename: Chang Min
authors.initials: CM
authors.lastname: Chung
mesh_terms: D000368:Aged; D004106:Dilatation; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D011379:Prognosis; D011655:Pulmonary Embolism / Q000401:mortality*; D012189:Retrospective Studies; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I