Catalytic asymmetric transfer hydrogenation of alpha-ketoesters with hantzsch esters.
C2-symmetric chiral copper(II)-bisoxazolines function as alcohol dehydrogenase mimics and catalyze highly enantioselective transfer hydrogenations of alpha-ketoesters with Hantzsch esters as a synthetic NADH analogue to give alpha-hydroxy esters in excellent enantioselectivities. [reaction: see text].
Yang
Jung Woon
JW
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
List
Benjamin
B
D000426:Alcohol Dehydrogenase / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis*; D018716:Molecular Mimicry; D009243:NAD / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism
D004952:Esters; D007659:Ketones; D009243:NAD; D003300:Copper; D000426:Alcohol Dehydrogenase