Isolation of a new anti-allergic phlorotannin, phlorofucofuroeckol-B, from an edible brown alga, Eisenia arborea.
Eisenia arborea is an edible brown alga occasionally used as a folk medicine in gynecopathy in Japan. A new phlorotannin was isolated from the alga during our search for naturally occurring anti-allergic compounds from edible algae guided by the inhibitory effect on histamine release from rat basophile leukemia (RBL)-2H3 cells. The phlorotannin was called "phlorofucofuroeckol-B." Its structure was determined by spectral analysis and chemical conversion. This paper describes the isolation, structure elucidation, and inhibitory effect of phlorofucofuroeckol-B on histamine release.
Sugiura
Yoshimasa
Y
Department of Technology, Kanehatsu Food Co., Ltd. Yutaka, Minami-ku, Nagoya, Aichi, Japan.
Matsuda
Kohji
K
Yamada
Yasuhiro
Y
Nishikawa
Masashi
M
Shioya
Kazufumi
K
Katsuzaki
Hirotaka
H
Imai
Kunio
K
Amano
Hideomi
H
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004147:Dioxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005502:Food; D006632:Histamine / Q000378:metabolism; D007795:Laminaria / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D051381:Rats
D018926:Anti-Allergic Agents; D001572:Benzofurans; D004147:Dioxins; C516536:phlorofucofuroeckol B; D006632:Histamine