title: Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells.
abstract: BACKGROUND
  A class of synthetic histone deacetylase (HDAC) inhibitors, which are hybrids of trichostatin A and MS-275 were previously developed. In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines.
  
  
  METHODS
  Human lung and breast cancer cells, as well as normal human bronchial epithelial (NHBE) cells were treated with SK-7041, and results were compared with those of cells treated with suberoylanilide hydroxamic acid (SAHA).
  
  
  RESULTS
  SK-7041 induced time-dependent histone hyperacetylation and showed more potent cytotoxicity than SAHA in cancer cells. These antiproliferative effects of SK-7041 were due to apoptotic cell death caused by G2/M-phase arrest and to a lesser extent to G1 arrest. Moreover, SK-7041 inhibited cancer cell proliferation more selectively than NHBE cell proliferation.
  
  
  CONCLUSIONS
  These results suggest that SK-7041 may have potential anticancer activity.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Keun-Wook
authors.initials: KW
authors.lastname: Lee
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Hwang-Phill
authors.initials: HP
authors.lastname: Kim
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Song
authors.forename: Sang Gyun
authors.initials: SG
authors.lastname: Kim
authors.forename: Tai Young
authors.initials: TY
authors.lastname: Kim
authors.forename: Hyun-Soon
authors.initials: HS
authors.lastname: Jong
authors.forename: Kyung Hae
authors.initials: KH
authors.lastname: Jung
authors.forename: Seock-Ah
authors.initials: SA
authors.lastname: Im
authors.forename: Tae-You
authors.initials: TY
authors.lastname: Kim
authors.forename: Noe Kyeong
authors.initials: NK
authors.lastname: Kim
authors.forename: Yung-Jue
authors.initials: YJ
authors.lastname: Bang
mesh_terms: D000107:Acetylation; D000577:Amides / Q000633:toxicity*; D017304:Annexin A5 / Q000378:metabolism; D000970:Antineoplastic Agents / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D001713:Biphenyl Compounds / Q000633:toxicity*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000633:toxicity*; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006877:Hydroxamic Acids / Q000633:toxicity; D015151:Immunoblotting; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured; D000077337:Vorinostat
chemical_list: D000577:Amides; D017304:Annexin A5; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; C497103:SK-7041; D000077337:Vorinostat