title: Which muscle relaxants should be used in day surgery and when.
abstract: OBJECTIVE
  After myorelaxants, myalgia and residual curarization may complicate recovery. Local anaesthesia and minimally invasive airway management make myorelaxants disputable in many outpatient procedures; nevertheless, neuromuscular blockade may be necessary to facilitate intubation or maintain muscle relaxation. Agent selection criteria are discussed.
  
  
  RESULTS
  Reduced hospital time is not associated with central neuraxial or peripheral nerve block. To reduce the risk for residual block, neuromuscular monitoring is mandatory. Use of reversal agents should not be restricted, although studies have shown higher incidence of postoperative nausea and vomiting following their use. Higher succinylcholine dosage is followed by lower incidence of myalgia. The relationship between fasciculation and myalgia is unclear. Sodium channel blockers or nonsteroidal antiinflammatory drugs may prevent myalgia. Sugammadex functions as a chelating agent.
  
  
  CONCLUSIONS
  Ear-nose-throat, open eye surgery and laparoscopy may demand myoresolution. Regional and minimally invasive anaesthesia are alternative solutions. Central and peripheral nerve blocks are associated with increased induction time, reduced pain scores, and decreased need for analgesics. Central neuraxial block, however, is associated with prolonged outpatient unit stay. Bad intubating conditions may cause pharyngo-laryngeal complications: the decision to avoid myorelaxants for tracheal intubation appears illogical. Incidence of postoperative residual curarization remains very high. Sugammadex offers new perspectives.
authors.affiliation: Department of Anaesthesia and Intensive Care, University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy. gbettelli@unimo.it
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bettelli
mesh_terms: D000556:Ambulatory Surgical Procedures; D000765:Anesthesia, Conduction / Q000009:adverse effects; D000768:Anesthesia, General / Q000009:adverse effects; D044182:Benzylisoquinolines; D002800:Cholinesterase Inhibitors / Q000009:adverse effects; D006801:Humans; D007442:Intubation, Intratracheal; D007546:Isoquinolines; D000077590:Mivacurium; D009125:Muscle Relaxants, Central; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects; D010149:Postoperative Pain / Q000139:chemically induced; D010243:Paralysis / Q000139:chemically induced / Q000188:drug therapy; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D013256:Steroids; D013390:Succinylcholine; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000627:therapeutic use
chemical_list: D044182:Benzylisoquinolines; D002800:Cholinesterase Inhibitors; D007546:Isoquinolines; D009125:Muscle Relaxants, Central; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D013256:Steroids; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077590:Mivacurium; D013390:Succinylcholine