Brain catecholamine alterations and pathological features with aging in Parkinson disease model rat induced by Japanese encephalitis virus.
We analyzed two disease model groups with rats infected by Japanese encephalitis virus (JEV), a 90-day group and a 180-day group after JEV infection. The time measured by the modified pole test showed that motor activities in these two groups were slower than those of age-matched control groups. Striatal dopamine (DA) levels were significantly decreased in all JEV-infected rats. Norepinephrine concentration in brain regions in the 180-day group was significantly decreased in the medulla oblongata and hypothalamus as compared with the control and 90-day group. Tyrosine hydroxylase-positive neurons were significantly decreased in both JEV-infected rat groups. These results suggest that DA decrease and pathological changes in JEV-infected model rats persist for a long time, at least up to 180 days, and this model will be useful for the evaluation of new anti-parkinsonian agents.
Hamaue
N
N
Department of Pharmacology, Health Sciences University of Hokkaido, Ishikari-Tobetsu, 061-0293, Hokkaido, Japan.
Ogata
A
A
Terado
M
M
Ohno
K
K
Kikuchi
S
S
Sasaki
H
H
Tashiro
K
K
Hirafuji
M
M
Minami
M
M
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000375:Aging / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D018349:Encephalitis Viruses, Japanese; D004672:Encephalitis, Japanese / Q000378:metabolism* / Q000473:pathology*; D005684:Gait / Q000502:physiology; D007150:Immunohistochemistry; D008125:Locus Coeruleus / Q000378:metabolism; D009043:Motor Activity / Q000502:physiology; D017072:Neostriatum / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D011916:Rats, Inbred F344
D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine