title: An observational study of vasopressin infusion during uncontrolled haemorrhagic shock in a porcine trauma model: Effects on bowel function.
abstract: The effects of vasopressin on the gut in a porcine uncontrolled haemorrhagic shock model are described. In eight anaesthetised pigs, a liver laceration was performed; when haemorrhagic shock was decompensated, all animals received 0.4 IU/kg vasopressin, followed by 0.08 IU/kg min over 30 min, which maintained a mean arterial blood pressure >40 mmHg. Subsequent surgical intervention, infusion of whole blood and fluids resulted in a stable cardiocirculatory status. Three hours after stabilisation, all pigs developed non-bloody diarrhoea which converted into normal bowel movements within 24 h. All histological samples retained 7 days after the experiment revealed no histopathological changes. In conclusion, in this small observational study of uncontrolled porcine haemorrhagic shock, a resuscitation strategy that included high dose vasopressin was associated with transient diarrhoea and good long term survival.
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. karl-heinz.stadlbauer@uibk.ac.at
authors.forename: Karl H
authors.initials: KH
authors.lastname: Stadlbauer
authors.forename: Volker
authors.initials: V
authors.lastname: Wenzel
authors.forename: Horst G
authors.initials: HG
authors.lastname: Wagner-Berger
authors.forename: Anette C
authors.initials: AC
authors.lastname: Krismer
authors.forename: Alfred
authors.initials: A
authors.lastname: Königsrainer
authors.forename: Wolfgang G
authors.initials: WG
authors.lastname: Voelckel
authors.forename: Claus
authors.initials: C
authors.lastname: Raedler
authors.forename: Christian A
authors.initials: CA
authors.lastname: Schmittinger
authors.forename: Karl H
authors.initials: KH
authors.lastname: Lindner
authors.forename: Guenter
authors.initials: G
authors.lastname: Klima
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003967:Diarrhea / Q000503:physiopathology; D004195:Disease Models, Animal; D007422:Intestines / Q000187:drug effects* / Q000503:physiopathology*; D008099:Liver / Q000293:injuries; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology; D013552:Swine; D014662:Vasoconstrictor Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014667:Vasopressins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014662:Vasoconstrictor Agents; D014667:Vasopressins