[Comparative evaluation of the safety of poly- and and oligoguanidines].
The antimicrobial activity and microenvironmental safety of poly- and oligoguanidine antiseptics were compared. E. coli and St. aureus test strains were found to be more sensitive to chlorohexidine bigluconate (CHB) upon a long (24 hour) exposure and to polyhexamethylene guanidine derivatives on short (30-second) contact. It is concluded that unlike polyguanidine antiseptics, CHB is more ecologically dangerous; when used for rapid disinfection, it can provoke impairment in the microenvironmental balance outside the area of application. The findings show it expedient to assess the microenvironmental safety of antimicrobial agents in order to prevent ecological catastrophes.
Timofeeva
M Iu
MIu
Matiushina
G P
GP
Krasniuk
I I
II
Rumiantsev
G I
GI
Vorob'ev
A A
AA
Nesvizhskiĭ
Iu V
IuV
Bogdanova
E A
EA
D000890:Anti-Infective Agents / Q000009:adverse effects*; D001419:Bacteria / Q000187:drug effects; D004787:Environmental Pollution / Q000009:adverse effects*; D019791:Guanidine / Q000009:adverse effects*; D006801:Humans
D000890:Anti-Infective Agents; D019791:Guanidine