Reproduction and fertility in human immunodeficiency virus type-1 infection.
Human immunodeficiency virus type-1 (HIV-1) affects mostly men and women in their reproductive years. For those who have access to highly active antiretroviral therapy (HAART), the course of HIV-1 infection has shifted from a lethal to a chronic disease. As a result of this, many patients with HIV-1 consider having offspring, as do other patients of reproductive age with chronic illnesses. This article summarizes the current knowledge on the presence of HIV in the male and female genital tract, the effects of HIV-1 infection and HAART on male and female fertility and the results of various assisted reproduction techniques (ART) in HIV-1-infected men and women who wish to have offspring.
van Leeuwen
E
E
Department of Obstetrics and Gynaecology, Centre for Reproductive Medicine, Academic Medical Centre, Amsterdam, The Netherlands. e.vanleeuwen@amc.uva.nl
Prins
J M
JM
Jurriaans
S
S
Boer
K
K
Reiss
P
P
Repping
S
S
van der Veen
F
F
D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005835:Genitalia / Q000821:virology*; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D027724:Reproductive Techniques, Assisted
D019380:Anti-HIV Agents