title: Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2).
abstract: A 40-year-old Japanese woman was admitted to Oita University Hospital with progressive dyspnea, consciousness disturbance and severe cytopenias. Her chest roentgenogram showed diffuse bilateral infiltrates. She was therefore forced to receive mechanical ventilation. Bone marrow aspiration disclosed numerous hemophagocytic histiocytes, thus suggesting her condition to be hemophagocytic syndrome. In addition, she also developed myocarditis and renal failure. Pulsed methylprednisolone, gamma-globulin, granulocyte colony-stimulating factor and sivelestat sodium hydrate were administrated, and thereafter the patient recovered from cytopenia and organ failure. Afterwards, influenza A H3N2 was detected from bronchial extracts. We should recognize that an influenza A virus infection can induce hemophagocytic syndrome and acute respiratory failure as the initial manifestations of multiple organ failure.
authors.affiliation: Division of Pulmonary Disease, Oita University Faculty of Medicine.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ando
authors.forename: Eishi
authors.initials: E
authors.lastname: Miyazaki
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hiroshige
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ashihara
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Okubo
authors.forename: Mami
authors.initials: M
authors.lastname: Ueo
authors.forename: Tetsujiro
authors.initials: T
authors.lastname: Fukami
authors.forename: Katsunori
authors.initials: K
authors.lastname: Sugisaki
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Tsuda
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ohishi
authors.forename: Shigenori
authors.initials: S
authors.lastname: Yoshitake
authors.forename: Takayuki
authors.initials: T
authors.lastname: Noguchi
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kumamoto
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001980:Bronchi / Q000821:virology; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications* / Q000821:virology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000188:drug therapy / Q000209:etiology*; D008775:Methylprednisolone / Q000627:therapeutic use; D009205:Myocarditis / Q000209:etiology; D011183:Postoperative Complications / Q000821:virology; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000628:therapy; D013449:Sulfonamides / Q000627:therapeutic use; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D007166:Immunosuppressive Agents; D013449:Sulfonamides; D005719:gamma-Globulins; D016179:Granulocyte Colony-Stimulating Factor; C069195:sivelestat; D005998:Glycine; D008775:Methylprednisolone