Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent.
Anethole shows synergistic effects on the antifungal activities of phytochemicals including polygodial and (2E)-undecenal against Saccharomyces cerevisiae and Candida albicans. It was found that a fungistatic dodecanol combined with a sublethal amount of anethole showed a fungicidal activity against S. cerevisiae. The MIC of dodecanol quickly reduced cell viability, but the cell viability recovered shortly after and then finally became no longer different from the control, indicating that the effect of dodecanol on this yeast was classified as sublethal damage. On the other hand, anethole completely restricted the recovery of cell viability. Therefore the expression of the synergistic effect was probably due to a blockade of the recovery process from dodecanol-induced stress.
Fujita
Ken-Ichi
K
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, USA.
Fujita
Tomoko
T
Kubo
Isao
I
D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects; D007851:Dodecanol / Q000737:chemistry; D004357:Drug Synergism; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010946:Plants, Medicinal; D017382:Reactive Oxygen Species / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D017382:Reactive Oxygen Species; D007851:Dodecanol; C006578:anethole