Synthesis of polycyclic benzonitriles via a one-pot aryl alkylation/cyanation reaction.
A norbornene-mediated palladium-catalyzed tandem alkylation/cyanation sequence is described in which an alkyl-aryl bond and a nitrile-aryl bond are formed in one pot. A variety of sterically hindered, five-, six-, and seven-membered ring benzonitriles were synthesized in good yields from easily accessible starting materials.
Mariampillai
Brian
B
Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada, M5S 3H6.
Alberico
Dino
D
Bidau
Valérie
V
Lautens
Mark
M