title: [The role of adjuvant chemotherapy in the treatment of non-small cell lung cancer].
abstract: Postoperative treatments for lung cancer have been evaluated for more than two decades, but in the majority of the studies (especially until 1990) no significant effect on survival has been shown. In 1995, a meta-analysis of eight cisplatin-based adjuvant chemotherapy trials with NSCLC showed a 13% reduction in the risk of death (P=0.08) and 5% benefit in 5-year survival. Among four positive trials (IALT, JBR10, ANITA and CALGB study) the absolute increase in the 5-year survival rates by adjuvant chemotherapy ranged from 4% to 15%, and the hazard ratios for death ranged from 0.6 to 0.86. The author analyzes the most important studies.
  
  
  CONCLUSIONS
  adjuvant chemotherapy after complete resection of NSCLC can be considered as a new standard of care in patients with good performance status. Patients should receive 4 cycles of platina-based chemotherapy beginning 4-8 weeks after surgery.
  
  
  CONCLUSIONS
  optimization of chemotherapy regimens including targeted therapy (such as EGFR inhibitors, angiogenesis inhibitors, anti-EGFR monoclonal antibodies). Further progress is anticipated through the integration of chemopreventive agents into the adjuvant treatment.
authors.affiliation: Pulmonológiai Klinika, Semmelweis Egyetem, AOK, Budapest, 1125, Hungary. szondy1@citromail.hu
authors.forename: Klára
authors.initials: K
authors.lastname: Szondy
authors.forename: Gábor
authors.initials: G
authors.lastname: Egri
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant / Q000639:trends; D019317:Evidence-Based Medicine; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D015201:Meta-Analysis as Topic; D020360:Neoadjuvant Therapy / Q000379:methods; D016019:Survival Analysis; D016896:Treatment Outcome