title: Attentional modulation of early-stage visual processing in schizophrenia.
abstract: This study shows that paying attention to the color of a visual stimulus is manifested by an early endogenous scalp-positive event-related brain potential (ERP) component, referred to as "selection positivity", that emerges within the first 100 ms after stimulus onset in healthy observers. In contrast, recently ill and chronically ill schizophrenia patients as well as patients at high risk for schizophrenia all failed to show this early ERP component while attending to color. These results suggest that a relatively early stage of visual-selective processing in posterior extrastriate cortex is disrupted in schizophrenia.
authors.affiliation: Department of Psychiatry, University of North Carolina, School of Medicine, Chapel Hill, NC 28223, USA. odin.vanderstelt@medizin.uni-magdeburg.de
authors.forename: Odin
authors.initials: O
authors.lastname: van der Stelt
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Lieberman
authors.forename: Aysenil
authors.initials: A
authors.lastname: Belger
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention; D016022:Case-Control Studies; D003118:Color Perception / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000145:classification / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014793:Visual Cortex / Q000503:physiopathology