[Growth factors and the hystologic picture of the liver in chronic viral hepatitis and hepatic cirrhosis].
The authors of the article present the results of studying correlations between growth factors and histological changes in the liver in 48 patients with chronic viral hepatitis and hepatic cirrhosis. The results show that the blood level of transforming growth factor-beta1 (TGF-beta1) increases, whilst the level of insulin-like growth factor-1 (IGF-1), epidermal growth factors (EGF), and regeneration index (RI) in general decrease according to increase in histological activity and the degree of hepatic fibrosis. There was a positive correlation between TGF-beta1 and a negative one between IGF-1 and EGF, as well as RI, on the one part, and the degree of hepatic inflammation and fibrosis, on the other. Measurement of the serum levels of growth factors with RI calculation broadens the possibility to evaluate inflammation and fibrosis in chronic viral hepatic diseases.
Iagoda
A B
AB
Koroĭ
P V
PV
Geĭvandova
N I
NI
Nikitina
O A
OA
Kastornaia
I V
IV
D000328:Adult; D005260:Female; D019694:Hepatitis B, Chronic / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000276:immunology* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000276:immunology*
D053773:Transforming Growth Factor beta1; D007334:Insulin-Like Growth Factor I