title: Do regulatory T-cells play a role in AIDS pathogenesis?
abstract: The impairment of adaptive immune responses to HIV and abnormalities in the immune regulatory function mechanisms during HIV infection have been regarded as key issues in AIDS pathogenesis since the early years of the pandemic. However, the multiple mechanisms underlying this impairment are still not fully understood. New emerging information shows that alterations in the number and/or function of regulatory T-cells may contribute to HIV pathogenesis. Thus, pharmacologic manipulation of regulatory T-cells as well as blocking the activity of other immunomodulatory molecules, such as indoleamine 2,3-dioxygenase, glucocorticoid-induced tumor necrosis factor receptor and PD1, might provide a valuable approach to redirect the immune system towards an efficient antiviral response.
authors.affiliation: Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
authors.forename: Adriano
authors.initials: A
authors.lastname: Boasso
authors.forename: Monica
authors.initials: M
authors.lastname: Vaccari
authors.forename: Jakob
authors.initials: J
authors.lastname: Nilsson
authors.forename: Gene M
authors.initials: GM
authors.lastname: Shearer
authors.forename: Jan
authors.initials: J
authors.lastname: Andersson
authors.forename: Valentina
authors.initials: V
authors.lastname: Cecchinato
authors.forename: Claire
authors.initials: C
authors.lastname: Chougnet
authors.forename: Genoveffa
authors.initials: G
authors.lastname: Franchini
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D015195:Drug Design; D006678:HIV / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects* / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology* / Q000821:virology
chemical_list: D007155:Immunologic Factors