Reassessment of cardiovascular risk in diabetes.
OBJECTIVE
To review recent trials and reassess cardiovascular risk in people with diabetes.


RESULTS
Recent clinical trials have tended to focus on lower-risk participants with diabetes who have had event rates considerably lower than participants in the early lipid trials. Statin studies have generally shown benefit in those without cardiovascular disease and at lower levels of low-density lipoprotein cholesterol. Results of fibrate and glitazone studies have been mixed; the question of benefit among statin-treated patients remains unanswered. Investigators failed to confirm the benefits of glucose control observed in the original Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction study possibly due to study design issues. Epidemiologic follow-up of the Diabetes Control and Complications Trial showed sustained benefit of glucose control. A number of studies have shown the benefit of inpatient control of blood glucose. We await the results of ongoing blood pressure trials and other ongoing trials, which should provide much new information. A conceptual model of cardiovascular risk for people with diabetes mellitus based on the UK Prospective Diabetes Study outcomes model is discussed.


CONCLUSIONS
The majority of adults with diabetes have a substantially greater risk compared with those without diabetes and a small percentage has very high risk. A minority of individuals may have considerably lower 10-year risk.
Jaffe
Jonathan R
JR
Merck & Co., Inc., Sumneytown Pike, West Point, Pennsylvania 19486, USA.
Nag
Soma S
SS
Landsman
Pamela B
PB
Alexander
Charles M
CM
D001786:Blood Glucose / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D048909:Diabetes Complications / Q000150:complications*; D003920:Diabetes Mellitus / Q000097:blood / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology; D008055:Lipids / Q000097:blood; D012307:Risk Factors
D001786:Blood Glucose; D008055:Lipids