The early repolarization variant--normal or a marker of heart disease in certain subjects.
The theory is advanced that the early repolarization variant may not always be benign and that it can become a substrate for ventricular arrhythmias, sudden death, and hypercontractility cardiomyopathy in some subjects, including certain high-performance athletes. In addition, it is suggested that it likely represents part of a spectrum of cardiovascular anomalies related to nonischemic ST elevation including Brugada syndrome, and that it may also have a molecular genetic origin of variable penetrance.
Boineau
John P
JP
Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. schuesslerd@wustl.edu
D001145:Arrhythmias, Cardiac / Q000145:classification* / Q000175:diagnosis*; D016477:Artifacts; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000379:methods*; D006801:Humans; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors