title: Central corneal thickness and corneal diameter in patients with childhood glaucoma.
abstract: OBJECTIVE
  To determine and compare the central corneal thickness (CCT) and corneal diameter among groups of patients with childhood glaucomas and assess the relationship between CCT and corneal diameter in these patients.
  
  
  METHODS
  A multicenter observational case series using prospective and retrospective data.
  
  
  METHODS
  Patients from the Scheie Eye Institute, Children's Hospital of Philadelphia, and Emory and Vanderbilt Medical Centers with childhood glaucomas were eligible to participate. Retrospective data on CCT and corneal diameter of these patients were collected when available; otherwise, patients were asked to return to the ophthalmology clinics for measurements. Patients with corneal edema or central corneal scarring were excluded. One hundred eighty four glaucomatous eyes from 109 patients (median age = 9.0 y; age range = 0 to 60 y) were included.
  
  
  RESULTS
  The mean CCT (+/-SE) was 651.1+/-63.5 microm for aphakic, 528.7+/-38.5 microm for Axenfeld-Rieger, and 563.4+/-67.9 microm for 1 degrees infantile eyes. The mean corneal diameter in aphakic, Axenfeld-Rieger, and 1 degrees infantile glaucoma eyes were 11.2+/-1.0, 12.5+/-0.9, and 13.2+/-1.2 mm, respectively. There was a significant difference in CCT and in corneal diameter between aphakic and 1 degrees infantile glaucoma eyes, and between aphakic and Axenfeld-Rieger eyes (P < 0.0001). There was a negative correlation between CCT and corneal diameter in all eyes (r = -0.41, P < 0.0001).
  
  
  CONCLUSIONS
  Patients with aphakic glaucoma are different from those with congenital glaucoma or Axenfeld-Rieger in CCT and corneal diameter. A patient with pediatric glaucoma and a larger corneal diameter was more likely to have a thinner CCT. Attention should be paid to the CCT of patients with childhood glaucomas for interpretation of intraocular pressure.
authors.affiliation: Scheie Eye Institute, Philadelphia, PA, USA. ttytai@yahoo.com
authors.forename: Tak Yee Tania
authors.initials: TY
authors.lastname: Tai
authors.forename: Monte D
authors.initials: MD
authors.lastname: Mills
authors.forename: Allen D
authors.initials: AD
authors.lastname: Beck
authors.forename: Karen M
authors.initials: KM
authors.lastname: Joos
authors.forename: Gui-Shuang
authors.initials: GS
authors.lastname: Ying
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Liu
authors.forename: Jody R
authors.initials: JR
authors.lastname: Piltz-Seymour
mesh_terms: D000293:Adolescent; D000328:Adult; D001036:Aphakia, Postcataract / Q000150:complications*; D001837:Body Weights and Measures; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005901:Glaucoma / Q000151:congenital* / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D014463:Ultrasonography