title: Familial adenomatous polyposis predisposes to pathologic exposure of the stomach to bilirubin.
abstract: BACKGROUND
  The role of duodenogastric reflux in the genesis of gastric polyps in familial adenomatous polyposis (FAP), although suggested by scintigraphy scanning studies, remains unclear.
  
  
  METHODS
  Twenty-four hour intragastric bilirubin monitoring with the Bilitec optoelectronic device was carried out in 25 FAP patients, of whom 19 had gastric polyps (fundic gland in 13, adenomatous in 2, and both histologic types in 4) on endoscopic examination. Gastric exposure to bilirubin was expressed as the percentage of total recording time that absorbance exceeded the threshold of 0.25 and was calculated in reference to values obtained from 25 healthy volunteers. Helicobacter pylori status of the stomach was checked as well.
  
  
  RESULTS
  Gastric exposure to bilirubin was pathologic in 14 (56%) patients. Gastric exposure to bilirubin was of longer duration in FAP patients than in healthy volunteers (mean+/-SEM: 19%+/-4% vs 6%+/-2%) (P<.005). It increased from healthy volunteers (6%+/-2%) to FAP patients without gastric polyps (10%+/-3%), and to FAP patients with gastric polyps (22%+/-5%) (P<.004). Bilirubin exposure times were similar in FAP patients with fundic gland polyps only and in those having either adenomatous polyps only or both types of polyps (24%+/-7% vs 17%+/-4%). No patient with pathologic gastric exposure to bilirubin as well as none having gastric polyps, had H. pylori in the antrum.
  
  
  CONCLUSIONS
  This study shows that gastric exposure to bilirubin is of longer duration in FAP patients than in healthy volunteers, and in FAP patients with gastric polyps than in those without polyps. This study supports the existence of a direct correlation between pathologic duodenogastric reflux (DGR), the absence of H. pylori in the antrum, and the presence of gastric polyps in FAP patients.
authors.affiliation: Upper Gastrointestinal Surgery Unit, Louvain Medical School, Brussels, Belgium, and Digestive Surgery and Liver Transplant Unit, Croix-Rousse Hospital, Lyon, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Mabrut
authors.forename: Renato
authors.initials: R
authors.lastname: Romagnoli
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Collard
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Saurin
authors.forename: Roger
authors.initials: R
authors.lastname: Detry
authors.forename: François
authors.initials: F
authors.lastname: Mion
authors.forename: Jacques
authors.initials: J
authors.lastname: Baulieux
authors.forename: Alex
authors.initials: A
authors.lastname: Kartheuser
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000502:physiology*; D004383:Duodenogastric Reflux / Q000503:physiopathology*; D005260:Female; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000473:pathology / Q000503:physiopathology*; D013270:Stomach / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D001663:Bilirubin