title: Variation of the serotonin transporter gene SLC6A4 in the susceptibility to migraine with aura.
abstract: To replicate a reported association between migraine with aura (MA) and a promoter polymorphism in the serotonin transporter gene (SLC6A4), we performed a case-control study in a large German sample comprising 472 patients with MA and 506 controls. Neither this polymorphism nor a systematic analysis with single nucleotide polymorphisms capturing the main haplotype diversity of the SLC6A4 locus provided evidence for a contribution of SLC6A4 to the predisposition of complex inherited MA.
authors.affiliation: Institute of Human Genetics, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Todt
authors.forename: J
authors.initials: J
authors.lastname: Freudenberg
authors.forename: I
authors.initials: I
authors.lastname: Goebel
authors.forename: A
authors.initials: A
authors.lastname: Heinze
authors.forename: K
authors.initials: K
authors.lastname: Heinze-Kuhn
authors.forename: M
authors.initials: M
authors.lastname: Rietschel
authors.forename: H
authors.initials: H
authors.lastname: Göbel
authors.forename: C
authors.initials: C
authors.lastname: Kubisch
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin