Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis.
The IL-4 receptor (IL-4R) and IL-13 genes are candidate genes in atopic diseases. The IL-4Ralpha chain and IL-13 promoter polymorphisms are gain-of-function mutations associated with atopy. We tested whether polymorphisms in the IL-4Ralpha chain and the coding region of the IL-13 gene are associated with allergic rhinitis in a Korean population. Polymerase chain reaction-based assays for IL-4Ralpha Gln551Arg and IL-13 exon 4 G2044A were used for genotyping. There were no differences in the frequencies of the genotypes and alleles of IL-4Ralpha between the controls and patients. The frequency of the IL-13 exon 4 2044A allele was statistically different between the controls and patients. Our results suggest that the IL-13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans, whereas the IL-4Ralpha Gln551Arg polymorphism is not related to allergic rhinitis.
Kim
Jeong Joong
JJ
Department of Anatomy, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea.
Min
Jung Youl
JY
Lee
Jae Hoon
JH
D000328:Adult; D044466:Asian People / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005091:Exons / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics*; D007723:Korea; D008297:Male; D017354:Point Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D053660:Receptors, Interleukin-13 / Q000235:genetics*; D012221:Rhinitis, Allergic, Perennial / Q000208:ethnology / Q000235:genetics*
D017931:DNA Primers; D053662:Interleukin-4 Receptor alpha Subunit; D053660:Receptors, Interleukin-13