title: Haemodynamic effects of intravenous quinaprilat in comparison to sodium nitroprusside in patients with chronic heart failure.
abstract: We compared the haemodynamic effects of intravenous boluses of the ACE inhibitor quinaprilat with an intravenous infusion of sodium nitroprusside in 23 patients with chronic heart failure (NYHA Class III or IV). At the highest drug doses, sodium nitroprusside significantly increased stroke volume index (+6.63 ml/m(2), p=0.045), whereas quinaprilat induced only a minor increase (+1.79 ml/m(2), n.s.).
authors.forename: Arne G
authors.initials: AG
authors.lastname: Kieback
authors.forename: Andrea
authors.initials: A
authors.lastname: Grohmann
authors.forename: Gert
authors.initials: G
authors.lastname: Baumann
authors.forename: Stephan B
authors.initials: SB
authors.lastname: Felix
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009599:Nitroprusside / Q000627:therapeutic use*; D013318:Stroke Volume / Q000187:drug effects*; D044005:Tetrahydroisoquinolines / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D044005:Tetrahydroisoquinolines; D014665:Vasodilator Agents; D009599:Nitroprusside; C054501:quinaprilat