title: Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia.
abstract: A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion.
authors.affiliation: Washington University School of Medicine, St. Louis, MO 63108, USA.
authors.forename: Monica L
authors.initials: ML
authors.lastname: Hulbert
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Scothorn
authors.forename: Julie A
authors.initials: JA
authors.lastname: Panepinto
authors.forename: J Paul
authors.initials: JP
authors.lastname: Scott
authors.forename: George R
authors.initials: GR
authors.lastname: Buchanan
authors.forename: Sharada
authors.initials: S
authors.lastname: Sarnaik
authors.forename: Robert
authors.initials: R
authors.lastname: Fallon
authors.forename: Jen-Yih
authors.initials: JY
authors.lastname: Chu
authors.forename: Winfred
authors.initials: W
authors.lastname: Wang
authors.forename: James F
authors.initials: JF
authors.lastname: Casella
authors.forename: Linda
authors.initials: L
authors.lastname: Resar
authors.forename: Brian
authors.initials: B
authors.lastname: Berman
authors.forename: Thomas
authors.initials: T
authors.lastname: Adamkiewicz
authors.forename: Lewis L
authors.initials: LL
authors.lastname: Hsu
authors.forename: Kimberly
authors.initials: K
authors.lastname: Smith-Whitley
authors.forename: Donald
authors.initials: D
authors.lastname: Mahoney
authors.forename: Gerald
authors.initials: G
authors.lastname: Woods
authors.forename: Masayo
authors.initials: M
authors.lastname: Watanabe
authors.forename: Michael R
authors.initials: MR
authors.lastname: DeBaun
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000628:therapy*; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D013997:Time Factors