C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients.
OBJECTIVE
The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population.


METHODS
We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age-matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products.


RESULTS
The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over-represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (chi(2) = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2-3.4).


CONCLUSIONS
The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.
Hoenicka
J
J
Psychiatry Service, Dual Diagnosis Unit, '12 de Octubre' University Hospital, Madrid, Spain. jhoenicka.hdoc@salud.madrid.org
Aragüés
M
M
Rodríguez-Jiménez
R
R
Ponce
G
G
Martínez
I
I
Rubio
G
G
Jiménez-Arriero
M A
MA
Palomo
T
T
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D013030:Spain
D017448:Receptors, Dopamine D2