Pre-hypertension as a predictor of hypertension in military aviators: a longitudinal study of 367 men.
BACKGROUND
Recently, the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure introduced the term "pre-hypertension" for systolic blood pressure (BP) levels of 120-139 and diastolic BP levels of 80-89 mmHg. Our aim was to establish the prevalence of this novel entity among young subjects, and to assess the rate of progression to hypertension.


METHODS
We retrospectively analyzed the data of a group of 367 male aviators who were examined at the age of 18 and who were followed for an average of 18 +/- 7 yr (range 3-37 yr). Systolic and diastolic BP, heart rate, and body mass index (BMI) were measured at the age of 18 and at the end of the follow-up.


RESULTS
At the age of 18, 176 subjects (48%) had pre-hypertension. Subjects with pre-hypertension had higher BP levels (132 +/- 6/76 +/- 8 vs. 115 +/- 6/72 +/- 7 mmHg; p < 0.001), heart rate (71 +/- 12 vs. 65 +/- 12 bpm; p < 0.001) and BMI (22.4 +/- 2.9 vs. 21.7 +/- 2.5 kg x m(-2); p < 0.05) than the subjects with normal BP. During the follow-up period, 110 subjects (30%), 77 with pre-hypertension and 33 with normal BP, developed hypertension. Pre-hypertensive subjects had an odds ratio of 3.7 (95% CI; 2.3-6.2) to develop hypertension as compared with subjects with normal BP.


CONCLUSIONS
Pre-hypertension is common and it predicts the development of frank hypertension. Thus, subjects with pre-hypertension should be closely followed and encouraged to begin lifestyle modification in order to prevent future complications.
Grossman
Alon
A
Israeli Air Force Aeromedical Center at Tel Hashomer, Israel. gross-e@zahav.net.il
Grossman
Chagai
C
Barenboim
Erez
E
Azaria
Bella
B
Goldstein
Liav
L
Grossman
Ehud
E
D000293:Adolescent; D000337:Aerospace Medicine; D015992:Body Mass Index; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007557:Israel; D016015:Logistic Models; D008297:Male; D008889:Military Personnel; D009784:Occupational Diseases / Q000453:epidemiology*; D012189:Retrospective Studies