Elevation of serum and urinary carbohydrate antigen 19-9 in benign hydronephrosis.
OBJECTIVE
The aim of this study was to find out the predictive role of serum and urinary carbohydrate antigen 19-9 levels in benign hydronephrosis and whether these levels are helpful for differentiation of complete or partial urinary obstruction.


METHODS
Fifty-four patients with, and 23 without, benign hydronephrosis were enrolled in this study. Serum and urinary carbohydrate antigen 19-9 were determined by the chemiluminescence enzyme immunometric assay method and these levels were correlated with clinical factors.


RESULTS
The mean serum (P < 0.0001) and urinary (P < 0.0001) carbohydrate antigen 19-9 and serum creatinine (P < 0.008) levels were significantly higher in the hydronephrosis group than the control group. There was significant correlation between serum and urinary carbohydrate antigen 19-9 levels in the hydronephrosis group (r = 0.639, P < 0.0001). In the hydronephrosis group, there were no significant differences between the serum creatinine, serum or urinary carbohydrate antigen 19-9 levels and the clinical features except symptom duration. The best cut-off value for the serum and urinary carbohydrate antigen 19-9 were found to be 4.84 U/mL and 29.35 U/mL, respectively.


CONCLUSIONS
Serum and urinary carbohydrate antigen 19-9 levels correlated with each other, were significantly elevated in patients with hydronephrosis and did not predict complete urinary obstruction. Benign hydronephrosis should be considered in the differential diagnosis of carbohydrate antigen 19-9 increments, as this is what is of most importance in clinical practice.
Aybek
Hulya
H
Department of Biochemistry, Pamukkale University School of Medicine, Denizli, Turkey.
Aybek
Zafer
Z
Sinik
Zafer
Z
Demir
Suleyman
S
Sancak
Burak
B
Tuncay
Levent
L
D000328:Adult; D000368:Aged; D018395:CA-19-9 Antigen / Q000097:blood* / Q000652:urine*; D003404:Creatinine / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D014570:Urologic Diseases / Q000097:blood / Q000473:pathology / Q000652:urine
D018395:CA-19-9 Antigen; D003404:Creatinine