title: Diastereoselective multicomponent synthesis of dihydropyridones with an isocyanide functionality.
abstract: [Structure: see text] In a search for new multicomponent strategies leading to valuable small heterocycles, a new highly diastereoselective four-component reaction (4CR) was found in which a phosphonate, nitriles, aldehydes, and isocyanoacetates combine to afford functionalized 3-isocyano-3,4-dihydro-2-pyridones. In this strategy, initially a 1-azadiene is generated, which is trapped in the same pot by an isocyanoacetate as the fourth component. Multicomponent reactions (MCRs) that lead to heterocycles containing isocyano substituents are unprecedented and offer many possibilities for further differentiation.
authors.affiliation: Vrije Universiteit Amsterdam, Department of Chemistry, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
authors.forename: Monica
authors.initials: M
authors.lastname: Paravidino
authors.forename: Robin S
authors.initials: RS
authors.lastname: Bon
authors.forename: Rachel
authors.initials: R
authors.lastname: Scheffelaar
authors.forename: Danielle J
authors.initials: DJ
authors.lastname: Vugts
authors.forename: Anass
authors.initials: A
authors.lastname: Znabet
authors.forename: Rob F
authors.initials: RF
authors.lastname: Schmitz
authors.forename: Frans J J
authors.initials: FJ
authors.lastname: de Kanter
authors.forename: Martin
authors.initials: M
authors.lastname: Lutz
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Spek
authors.forename: Marinus B
authors.initials: MB
authors.lastname: Groen
authors.forename: Romano V A
authors.initials: RV
authors.lastname: Orru