title: Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production.
abstract: Glucuronoxylomannan (GXM) is the major capsular polysaccharide of Cryptococcus neoformans. GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.
authors.affiliation: Laboratório de Estudos Integrados em Bioquímica Microbiana, Departamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude (CCS), Rio de Janeiro, Brazil.
authors.forename: Fabiane M
authors.initials: FM
authors.lastname: Barbosa
authors.forename: Fernanda L
authors.initials: FL
authors.lastname: Fonseca
authors.forename: Rodrigo T
authors.initials: RT
authors.lastname: Figueiredo
authors.forename: Marcelo T
authors.initials: MT
authors.lastname: Bozza
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Leonardo
authors.initials: L
authors.lastname: Nimrichter
authors.forename: Marcio L
authors.initials: ML
authors.lastname: Rodrigues
mesh_terms: D003455:Cryptococcus neoformans / Q000472:pathogenicity; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D011134:Polysaccharides / Q000494:pharmacology*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D011956:Receptors, Cell Surface / Q000502:physiology*
chemical_list: D016209:Interleukin-8; D018950:Lipopolysaccharide Receptors; D011134:Polysaccharides; D011956:Receptors, Cell Surface; C027478:glucuronoxylomannan