Can dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy?
As phototoxic skin reactions caused by psoralen are induced by wavelengths within the UVA1 spectrum, we assessed the potential of the small amount of psoralen in a normal diet to provoke phototoxicity in volunteers with skin types I and II. Threshold erythema was unaffected by ingestion of a 200-g portion of parsnip.
Beattie
Paula E
PE
Photobiology Unit, Dermatology Department, University of Dundee, Ninewells Hospital and Medical School, United Kingdom. paula.beattie@northglasgow.scot.nhs.uk
Wilkie
Murray J V
MJ
Smith
Gillian
G
Ferguson
James
J
Ibbotson
Sally H
SH
D000328:Adult; D000368:Aged; D000077102:Apium / Q000009:adverse effects / Q000737:chemistry; D004032:Diet; D004890:Erythema / Q000139:chemically induced* / Q000209:etiology; D005260:Female; D005511:Food Handling; D011564:Furocoumarins / Q000009:adverse effects* / Q000032:analysis; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000009:adverse effects / Q000032:analysis; D008875:Middle Aged; D028529:Pastinaca / Q000009:adverse effects / Q000737:chemistry; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000209:etiology; D019441:Plant Epidermis / Q000009:adverse effects / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects* / Q000032:analysis; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014467:Ultraviolet Therapy / Q000009:adverse effects
D011564:Furocoumarins; D011838:Radiation-Sensitizing Agents; D008730:Methoxsalen