title: Progress towards the clinical application of helper-dependent adenoviral vectors for liver and lung gene therapy.
abstract: This review focuses on recent developments in helper-dependent adenoviral technology and preclinical studies for helper-dependent adenovirus-mediated liver- and lung-directed gene therapy. Studies highlighting the tremendous potential of these vectors are reviewed, together with some important obstacles that will need to be addressed before clinical utility.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza T619, Houston, TX 77030, USA.
authors.forename: Nicola
authors.initials: N
authors.lastname: Brunetti-Pierri
authors.forename: Philip
authors.initials: P
authors.lastname: Ng
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D018014:Gene Transfer Techniques / Q000639:trends; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics*; D006378:Helper Viruses / Q000235:genetics*; D006801:Humans; D008107:Liver Diseases / Q000628:therapy*; D008171:Lung Diseases / Q000628:therapy*