[New medications; zonisamide].
Zonisamide is an adjuvant for the treatment of patients with partial epilepsy, with or without secondary generalisation. It affects, among other things, the voltage-sensitive sodium and calcium channels, thus disrupting synchronised neuronal firing; as a result, it diminishes the spread of seizure discharges.
Cohen
A F
AF
Centre for Human Drug Research, Leiden. ac@chdr.nl
van Bronswijk
H
H
D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D015220:Calcium Channels / Q000187:drug effects; D004828:Epilepsies, Partial / Q000188:drug therapy*; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology / Q000627:therapeutic use*; D015222:Sodium Channels / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D016896:Treatment Outcome; D000078305:Zonisamide
D000927:Anticonvulsants; D015220:Calcium Channels; D007555:Isoxazoles; D015222:Sodium Channels; D000078305:Zonisamide