Neurotrophins and peripheral neuropathies.
Peripheral neuropathy is a common disorder seen in general neurology and neuromuscular specialty clinics. Treatment options directed at the underlying cause can only be offered in a handful of conditions, such as those with possible autoimmune etiology. The remainder fall into the idiopathic or genetic category with no known treatment. This review surveys the evidence supporting the rationale for the therapeutic use of neurotrophins and other neurotrophic factors in these disorders in relationship to the underlying pathobiological process. Previous clinical trials are assessed, and increasingly better understood and appreciated therapeutic potential of neurotrophins is emphasized.
Sahenk
Zarife
Z
Neuromuscular Pathology, The Ohio State University, Columbus Children's Research Institute, Neuromuscular Program, Columbus, Ohio 43205, USA. sahenkz@ccri.net
D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism*
D009414:Nerve Growth Factors