Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study.
This multi-voxel, phosphorus magnetic resonance spectroscopy ((31)P MRS) study examined the prefrontal cortex (PFC), basal ganglia (BG) and superior temporal (ST) region in 10 children with attention-deficit/hyperactivity disorder (ADHD) and 15 healthy controls. ADHD patients had lower PFC and BG phosphomonoester (PME) levels compared to healthy children. No differences were noted in the ST. These deficits in membrane phospholipid (MPL) precursor levels suggest reduced mass of cellular MPLs due to a possible underdevelopment of neuronal processes and synapses in ADHD.
Stanley
Jeffrey A
JA
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, University Health Center 9B-28, 4201 St. Antoine Street, Detroit, MI 48201, USA.
Kipp
Heidi
H
Greisenegger
Erika
E
MacMaster
Frank P
FP
Panchalingam
K
K
Pettegrew
Jay W
JW
Keshavan
Matcheri S
MS
Bukstein
Oscar G
OG
D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000503:physiopathology*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000175:diagnosis / Q000503:physiopathology; D001479:Basal Ganglia / Q000503:physiopathology*; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D009415:Nerve Net / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D010743:Phospholipids / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism; D017397:Prefrontal Cortex / Q000503:physiopathology*; D013569:Synapses / Q000502:physiology; D013702:Temporal Lobe / Q000503:physiopathology*
D008563:Membrane Lipids; D010743:Phospholipids; D010758:Phosphorus