title: Renal transplants from category III non-heart-beating donors with evidence of pre-arrest acute renal failure.
abstract: Kidneys transplanted from non-heart-beating donors (NHBDs) have been exposed to varying degrees of ischemic damage after death. Category III donors have invariably been managed, treated, and investigated in a hospital setting prior to arrest and death. Some therefore exhibit evidence of renal dysfunction and even acute renal failure (ARF) before death. Many surgeons would regard a NHBD with pre-arrest evidence of ARF as too marginal for renal transplantation. This retrospective study examines five Maastricht category III NHBD donors with evidence of pre-arrest ARF. We compare 3- and 12-month GFR outcome data from the nine resulting transplants with 40 category III NHBD transplants with normal pre-arrest renal function. The mean GFR at 3 months was 45.4 and 43.8 for the ARF and normal group, respectively. At 12 months the GFR was 42.2 and 44.7 in the ARF and normal groups, respectively. Thus evidence of ARF pre-arrest does not preclude successful category III NHBD renal transplantation.
authors.affiliation: Liver and Renal Transplant Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom. alex@navarrol.wanadoo.co.uk
authors.forename: A P
authors.initials: AP
authors.lastname: Navarro
authors.forename: S
authors.initials: S
authors.lastname: Sohrabi
authors.forename: C
authors.initials: C
authors.lastname: Wilson
authors.forename: A
authors.initials: A
authors.lastname: Sanni
authors.forename: H
authors.initials: H
authors.lastname: Wyrley-Birch
authors.forename: D
authors.initials: D
authors.lastname: Vijayanand
authors.forename: M
authors.initials: M
authors.lastname: Reddy
authors.forename: D
authors.initials: D
authors.lastname: Rix
authors.forename: D
authors.initials: D
authors.lastname: Manas
authors.forename: D
authors.initials: D
authors.lastname: Talbot
mesh_terms: D058186:Acute Kidney Injury; D005919:Glomerular Filtration Rate; D006323:Heart Arrest; D006801:Humans; D007668:Kidney; D016030:Kidney Transplantation / Q000379:methods* / Q000502:physiology; D013997:Time Factors; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods; D016896:Treatment Outcome