title: A novel route to fabricate the biomedical material: structure strategy and the biologically active ions controllable release.
abstract: The multiple biologically active trace element delivery remains a problem in regeneration medicine and tissue engineering. A novel approach to fabricate the biologically active trace elements assembly in a core-shell system for cooperative controlled-release has been proposed. Firstly, using a pH-dependent electrostatic interaction, zinc and strontium ions were incorporated into the silica gel nanospheres. Subsequently a porous octacalcium phosphate (OCP) shell was coated on the nanospheres tailored by poly(acrylate sodium) molecules. In vitro test shows that this hierarchical multilayered nanostructure can achieve a shell-/pH-dependent controlled-release of silicon, strontium and zinc ions. The wet-chemical route to selective synthesis of the core-shell Silica@OCP system may provide a general model to develop cooperative encapsulation of biologically active ions in a silica-based system by using layer-by-layer assembly technique for controlled-release in biomedical areas.
authors.affiliation: State key Lab of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Zhongru
authors.initials: Z
authors.lastname: Gou
authors.forename: Wenjian
authors.initials: W
authors.lastname: Weng
authors.forename: Weiqi
authors.initials: W
authors.lastname: Yan
authors.forename: Piyi
authors.initials: P
authors.lastname: Du
authors.forename: Gaorong
authors.initials: G
authors.lastname: Han
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
mesh_terms: D002130:Calcium Phosphates / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes; D016062:Porosity; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013324:Strontium / Q000008:administration & dosage* / Q000737:chemistry; D013499:Surface Properties; D014131:Trace Elements / Q000008:administration & dosage* / Q000737:chemistry; D015032:Zinc / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D014131:Trace Elements; C022045:octacalcium phosphate; D058428:Silica Gel; D012822:Silicon Dioxide; D015032:Zinc; D013324:Strontium