Nontraumatic spinal epidural hematoma associated with clopidogrel.
A 73-year-old female treated with clopidogrel for vascular disease presented with sudden onset of back pain, urinary retention and paraplegia. MRI scans demonstrated a thoracolumbar epidural hematoma and the patient underwent emergency laminectomy for evacuation of the hematoma. A possible causal link between clopidogrel and occurrence of the hemorrhage is discussed and the literature on spontaneous spinal hematomas is reviewed.
Karabatsou
K
K
Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery NHS Trust, Liverpool, United Kingdom.
Sinha
A
A
Das
K
K
Rainov
N G
NG
D000368:Aged; D001416:Back Pain / Q000209:etiology; D000077144:Clopidogrel; D005260:Female; D046748:Hematoma, Epidural, Spinal / Q000139:chemically induced* / Q000150:complications / Q000601:surgery; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000188:drug therapy; D010264:Paraplegia / Q000209:etiology; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D013131:Spine / Q000473:pathology; D020521:Stroke / Q000188:drug therapy; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014549:Urinary Incontinence / Q000209:etiology
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine