Method for the solid-phase parallel synthesis of a 6-alkylamino-2-(functionalized-aminomethyl)-2H-1-benzopyran Library.
A 2000-member library of benzopyran analogues was prepared by using a solid-phase synthesis protocol. Polymer-bound 6-alkylaminobenzopyrans 7 were synthesized as part of a first generation diversification step by employing reactions of a variety of alkyl halides with the amine 6. Transformations of the resin-bound intermediates 8 formed in this manner by reactions with acid halides, sulfonyl chlorides, and isocyanates leads to introduction of the second level of diversification found in the series of 6-alkylamino-2-(functionalized-aminomethyl)-2-methyl-2H-1-benzopyran analogues 11 and 12.
Hwang
Jong Yeon
JY
Medicinal Science Division, Korea Research Institute of Chemical Technology, Yusung-gu, Daejeon 305-600, Korea.
Choi
Hyung-Sub
HS
Seo
Jin-soo
JS
La
Hyun-Ju
HJ
Yoo
Sung-eun
SE
Gong
Young-Dae
YD
D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D013237:Stereoisomerism
D001578:Benzopyrans