Specific expression of substance P in synovial tissues of patients with symptomatic, non-reducing internal derangement of the temporomandibular joint: comparison with clinical findings.
Our aim was to find out the extent of expression of substance P in synovial tissue from the human temporomandibular joints (TMJ) with symptomatic, non-reducing internal derangement, and to investigate the relationship between substance P and clinical findings. Fifty-four joints in 54 patients were examined immunohistochemically. Specimens of synovial tissue from 10 joints in 8 subjects with habitual dislocation of the TMJ with no pain were examined as controls. Cells that stained for substance P were found mainly among the endothelial cells in the blood vessels beneath the lining cells in synovial tissues from 47 of the 54 joints (87%) with internal derangement and from 5 of the 10 control joints. The extent score of cells that stained for substance P in joints with internal derangement was significantly higher than that in controls (p=0.02). The extent score of these cells did not correlate with pain in the joint or the degree of synovitis. These results suggest that substance P may have some roles in both the physiological and pathological conditions in patients with symptomatic internal derangement of the TMJ.
Sato
Jun
J
Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan. jun-s@den.hokudai.ac.jp <jun-s@den.hokudai.ac.jp>
Segami
Natsuki
N
Yoshitake
Yoshino
Y
Kaneyama
Keiseki
K
Yoshimura
Hiroshi
H
Fujimura
Kazuma
K
Kitagawa
Yoshimasa
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000378:metabolism; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D004204:Joint Dislocations / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020078:Neurogenic Inflammation / Q000378:metabolism / Q000473:pathology; D018709:Statistics, Nonparametric; D013373:Substance P / Q000032:analysis / Q000096:biosynthesis*; D013583:Synovial Membrane / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D013585:Synovitis / Q000378:metabolism / Q000473:pathology; D013704:Temporomandibular Joint / Q000378:metabolism / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000378:metabolism* / Q000473:pathology
D013373:Substance P