Substrate-directed stereoselectivity in vicinal diamine-catalyzed synthesis of warfarin.
[Structure: see text] A new mechanism involving a diimine intermediate is proposed for vicinal diamine-catalyzed synthesis of warfarin. Decreasing the NCCN dihedral angle by varying the diamine results in an increase in the enantioselectivity of warfarin synthesis.
Kim
Hyunwoo
H
Department of Chemistry, University of Toronto, 80 St. Geroge Street, Toronto, ON, M5S 3H6 Canada.
Yen
Cindy
C
Preston
Philippa
P
Chin
Jik
J