A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient.
A molecular virology analysis performed in an HIV-hepatitis B virus (HBV) co-infected patient showed the emergence of an unusual HBV polymerase gene mutation (rt A181T) under adefovir therapy, conferring resistance to adefovir but not to tenofovir, as proved by in-vitro phenotypic analysis. This observation suggests that careful monitoring of co-infected patients is required to diagnose HBV resistance to nucleos(t)ide analogues, and that tenofovir may be active at least against some of the adefovir-resistant strains.
Lacombe
Karine
K
INSERM U707, Epidémiologie, Systèmes d'informations, Modélisation, Paris, F-75012 France.
Ollivet
Aurélie
A
Gozlan
Joel
J
Durantel
Sandra
S
Tran
Nathalie
N
Girard
Pierre-Marie
PM
Zoulim
Fabien
F
D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D024882:Drug Resistance, Viral; D015684:Gene Products, pol / Q000235:genetics*; D015658:HIV Infections / Q000150:complications*; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D063065:Organophosphonates / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D000068698:Tenofovir
D015684:Gene Products, pol; D063065:Organophosphonates; C066027:P protein, Hepatitis B virus; D018894:Reverse Transcriptase Inhibitors; C053001:adefovir; D000068698:Tenofovir; D000225:Adenine