[Reversible dilated cardiomyopathy in a patient with acute, advanced heart failure and intense endothelial inflammatory reaction in endomyocardial biopsy--a case report].
Inflammatory response of the endothelium has been increasingly recognized in the aetiopathogenesis of sporadic dilated cardiomyopathy (DCM). It has been shown that up to 2/3 of patients with DCM have immunohistological evidence of enhanced activation of the endothelium. We present a case of a middle-aged patient with a history of hypertension and hyperlipidaemia who developed sudden significant left ventricular dysfunction following flu-like syndrome. Endomyocardial biopsy revealed no myocarditis, but immunohistological features of endothelial activation were present. Additionally, increasing titers of IgG antibodies against PvB19 were observed. During 18 months of standard heart failure treatment along with statin therapy, we observed a significant recovery of left ventricular systolic function, and in this way, reversible dilated cardiomyopathy.
Tyczyński
Paweł
P
I Klinika Choroby Wieńcowej, Instytut Kardiologii, ul. Alpejska 42, 04-628 Warszawa. medykpol@wp.pl
Bilińska
Zofia T
ZT
Dzielińska
Zofia
Z
Cedro
Krzysztof
K
Grzybowski
Jacek
J
Walczak
Ewa
E
Michalak
Ewa
E
Wagner
Teresa
T
Ruzyłło
Witold
W
D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000276:immunology* / Q000473:pathology / Q000821:virology; D004699:Endocardium / Q000276:immunology* / Q000473:pathology / Q000821:virology; D004730:Endothelium, Vascular / Q000473:pathology; D006333:Heart Failure / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000276:immunology* / Q000473:pathology / Q000821:virology; D010322:Parvoviridae Infections / Q000150:complications*; D018487:Ventricular Dysfunction, Left / Q000276:immunology / Q000473:pathology / Q000821:virology