Proteomic analysis of hypertrophied myocardial protein patterns in renovascularly hypertensive and spontaneously hypertensive rats.
The cardiac protein profiles of spontaneously hypertensive and renovascularly hypertensive hypertrophy showed a significant alteration compared with normal hearts. Most proteins with significant modulations in their expressions belong to the category of metabolic and stress-related proteins. Among these proteins, glutathione-S-transferase mu2 and short-chain acyl-CoA dehydrogenase may be two candidate proteins associated with left ventricular hypertrophy in spontaneously hypertensive rats.
Zhou
Si-Gui
SG
Pharmacology and Toxicology Laboratory and Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China.
Zhou
Shu-Feng
SF
Huang
He-Qing
HQ
Chen
Jian-Wen
JW
Huang
Min
M
Liu
Pei-Qing
PQ
D042964:Acyl-CoA Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001794:Blood Pressure; D006332:Cardiomegaly / Q000235:genetics*; D004195:Disease Models, Animal; D004562:Electrocardiography; D015180:Electrophoresis, Gel, Two-Dimensional; D005982:Glutathione Transferase / Q000235:genetics; D006978:Hypertension, Renovascular / Q000235:genetics*; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics* / Q000302:isolation & purification; D020543:Proteome; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018487:Ventricular Dysfunction, Left
D011506:Proteins; D020543:Proteome; D012333:RNA, Messenger; D042964:Acyl-CoA Dehydrogenase; D005982:Glutathione Transferase