Effect of reduced oxygen concentrations on the outcome of in vitro fertilization.
We compared the effects of two standard oxygen concentrations, physiological (5% O(2), 5% CO(2), and 90% N(2)) and atmospheric (5% CO(2) with the balance as air), on fertilization, embryo development, and pregnancy rate in 106 patients undergoing IVF, excluding donor oocyte cycles and preimplantation genetic diagnosis cycles. The differences in oxygen concentration did not significantly affect fertilization rate, blastocyst formation, or pregnancy rate, but there was a significant difference in mean embryo score between physiological and atmospheric groups on day 3.
Kea
Bory
B
School of Medicine, Stanford University, Stanford, California 94305, USA.
Gebhardt
Janice
J
Watt
Jill
J
Westphal
Lynn M
LM
Lathi
Ruth B
RB
Milki
Amin A
AA
Behr
Barry
B
D000328:Adult; D004624:Embryo Transfer; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D046509:Tissue Culture Techniques / Q000379:methods*; D016896:Treatment Outcome
D010100:Oxygen