Ultrasound biomicroscopy in asymmetric pigment dispersion syndrome and pigmentary glaucoma.
OBJECTIVE
To identify differences in anterior chamber anatomy among patients with asymmetric pigment dispersion syndrome and no other discernible cause for the asymmetry.


METHODS
Ultrasound biomicroscopy and A-scan biometry were performed on both eyes of 13 patients with asymmetric pigment dispersion syndrome without a known cause for asymmetric involvement. A radial perpendicular image in the horizontal temporal meridian detailing the scleral spur, angle anatomy, and iris configuration was obtained for each eye by 2 examiners.


RESULTS
There were no differences in lens thickness (P = .33), refractive error (P = .84), or axial length (P = .99) between more and less affected eyes. However, the mean +/- SD iris concavity (P<.001), iris-lens contact distance (P = .02), and distance from the scleral spur to the iris insertion (0.42 +/- 0.11 vs 0.29 +/- 0.06 mm) (P = .002) were greater in the more affected eye of each patient.


CONCLUSIONS
A more posterior iris insertion predisposes to the phenotypic expression of pigment dispersion syndrome.
Kanadani
Fabio N
FN
Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY 10003, USA.
Dorairaj
Syril
S
Langlieb
Alan M
AM
Shihadeh
Wisam A
WA
Tello
Celso
C
Liebmann
Jeffrey M
JM
Ritch
Robert
R
D000328:Adult; D000867:Anterior Chamber / Q000000981:diagnostic imaging*; D017889:Exfoliation Syndrome / Q000000981:diagnostic imaging*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging*; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000000981:diagnostic imaging*; D007908:Lens, Crystalline / Q000000981:diagnostic imaging; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged