Analysis of domperidone in pharmaceutical formulations and wastewater by differential pulse voltammetry at a glassy-carbon electrode.
The redox characteristics of the drug domperidone at a glassy-carbon electrode (GCE) in aqueous media were critically investigated by differential-pulse voltammetry (DPV) and cyclic voltammetry (CV). In Britton-Robinson (BR) buffer of pH 2.6-10.3, an irreversible and diffusion-controlled oxidation wave was developed. The dependence of the CV response of the developed anodic peak on the sweep rate (nu) and on depolizer concentration was typical of an electrode-coupled chemical reaction mechanism (EC) in which an irreversible first-order reaction is interposed between the charges. The values of the electron-transfer coefficient (alpha) involved in the rate-determining step calculated from the linear plots of E (p,a) against ln (nu) in the pH range investigated were in the range 0.64 +/- 0.05 confirming the irreversible nature of the oxidation peak. In BR buffer of pH 7.6-8.4, a well defined oxidation wave was developed and the plot of peak current height of the DPV against domperidone concentration at this peak potential was linear in the range 5.20 x 10(-6) to 2.40 x 10(-5) mol L(-1) with lower limits of detection (LOD) and quantitation (LOQ) of 6.1 x 10(-7) and 9.1 x 10(-7) mol L(-1), respectively. A relative standard deviation of 2.39% (n = 5) was obtained for 8.5 x 10(-6) mol L(-1) of the drug. These DPV procedures were successfully used for analysis of domperidone in the pure form (98.2 +/- 3.1%), dosage form (98.35 +/- 2.9%), and in tap (97.0 +/- 3.6%) and wastewater (95.0 +/- 2.9%) samples. The method was validated by comparison with standard titrimetric and HPLC methods. Acceptable error of less than 3.3% was also achieved.
El-Shahawi
M S
MS
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia. mohammad_el_shahawi@yahoo.co.uk
Bahaffi
S O
SO
El-Mogy
T
T
D004294:Domperidone / Q000032:analysis*; D004563:Electrochemistry / Q000379:methods; D007220:Industrial Waste / Q000032:analysis; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000032:analysis; D014867:Water / Q000032:analysis; D014874:Water Pollutants, Chemical / Q000032:analysis
D007220:Industrial Waste; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical; D014867:Water; D004294:Domperidone