[Protective effect of effective parts of Zingiber Offecinal on vascular endothelium of the experimental hyperlipidemic rats].
OBJECTIVE
To observe the influence of effective parts of Zingiber Officinale on serum IL-6, TNF-alpha in oroler to investigate the protective effects of the effective parts of Zingiber Officinal (EPZ) on endothelium of the experimental hyperlipidemic rats and the mechanism of its effects.


METHODS
The hyperlipidemia model of rats was constructed by feeding high-fat forage and filled with the effective parts of Zingiber Officinale 200 mg/kg, 400 mg/kg, 800 mg/kg every day for 13 weeks. Blood was drawn to determine both the level of serum IL-6 and TNF-alpha. All the aortaes were taken to oberserve morphologic change and the intima-media thickness were detected.


RESULTS
The effective parts of Zingiber Officinale could markedly decrease intima-media thickness, but had no marked influence in the level of serum IL-6 and TNF-alpha.


CONCLUSIONS
The Effect Parts of Zingiber Officinale has the effect of protection of the endothelia of hyperlipidemia rats, which has nothing with the level of serum IL-6 and TNF-alpha.
Wu
Cai-Xia
CX
Department of Pharmacology, School of Medicine Shandong University, Jinan 250012, China. wcxzzl@eyou.com
Wei
Xin-Bing
XB
Ding
Hua
H
Sun
Xia
X
Cheng
Xiu-Min
XM
D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000517:prevention & control; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects; D006949:Hyperlipidemias / Q000097:blood / Q000473:pathology*; D015850:Interleukin-6 / Q000097:blood*; D008148:Lovastatin / Q000494:pharmacology; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D030521:Zingiberaceae / Q000737:chemistry*
D002791:Cholesterol, Dietary; D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D008148:Lovastatin