Trans-arterial chemoembolization (TACE) of liver metastases from colorectal cancer using irinotecan-eluting beads: preliminary results.
OBJECTIVE
The purpose of the study was to evalutate the feasibility of irinotecan drug-eluting beads (DC Bead) administered as trans-arterial chemoembolization (TACE) in patients with liver metastases from colorectal cancer (CRC).


METHODS
Ten patients with liver metastases from CRC were treated with TACE adopting irinotecan-eluting beads at a dose of 100 mg every 3 weeks. Computed Tomography (CT) was performed 24h before and after TACE.


RESULTS
TACE with irinotecan eluting beads was found to be feasible and well-tolerated. Right upper quadrant pain (RUQP) lasting 4 days (range 2-7) was reported by all the patients. After 30 days, a reduction >50% of CEA levels and of the lesional contrast enhancement was observed in all the patients.


CONCLUSIONS
Irinotecan drug-eluting beads administered as TACE were shown to be active and safe in patients with liver metastases from CRC.
Aliberti
C
C
Department of Interventional Radiology Delta Hospital, via delle Tombe 65, 47023 Lagosanto, Ferrara, Italy. camy.ali@libero.it
Tilli
M
M
Benea
G
G
Fiorentini
G
G
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016461:Chemoembolization, Therapeutic; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D004337:Drug Carriers; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D004337:Drug Carriers; D000077146:Irinotecan; D002166:Camptothecin