Isokibdelones: novel heterocyclic polyketides from a Kibdelosporangium sp.
[Structure: see text] The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare actinomycete, Kibdelosporangium sp. The structures of the isokibdelones were assigned by spectroscopic analysis and chemical interconversion. A proposed biosynthesis requires a novel molecular twist that generates an unprecedented heterocyclic system and differentiates the isokibdelones from their kibdelone co-metabolites. SAR analysis on the isokibdelones further defines the anticancer pharmacophore of these novel polyketides.
Ratnayake
Ranjala
R
Centre for Molecular Biodiversity, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Lacey
Ernest
E
Tennant
Shaun
S
Gill
Jennifer H
JH
Capon
Robert J
RJ
D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D018942:Macrolides