title: Production of sepedonin by Sepedonium chrysospermum NT-1 in submerged culture.
abstract: Strains of Sepedonium chrysospermum and the anamorph strain of Hypomyces chrysospermus (congruent with Apiocrea chrysosperma) were isolated and purified from parasitic filamentous fungi on the fruiting bodies of Boletaceae, such as the Gyroponus and Suillus genera in Japan, and identified from formations of conidia and chlamydospores. It is known that these strains produce sepedonin. S. chrysospermum NT-1 strain was selected from these strains and isolated. As the optimum medium (CY-1 medium), 0.1% yeast extract was added to the fruiting-body-forming medium (C medium) of Schizophyllum commune. After 8 days of growth on CY-1 medium, the yield of sepedonin was about 34 mg per 2 g of glucose added. This sepedonin seemed to inhibit the growth of various gram-positive and gram-negative bacteria, yeasts and molds.
authors.affiliation: Research Institute of Technology, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan. nagao@rins.ous.ac.jp
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Nagao
authors.forename: Naho
authors.initials: N
authors.lastname: Yoshida
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Iwai
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakai
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toshiro
authors.initials: T
authors.lastname: Miyahara
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota / Q000502:physiology*; D002176:Candida albicans / Q000187:drug effects; D002241:Carbohydrates / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006999:Hypocreales / Q000187:drug effects / Q000502:physiology*; D014334:Tropolone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D002241:Carbohydrates; C518175:sepedonin; D014334:Tropolone