[Acute hemorrhagic colitis induced by the neuraminidase inhibitor oseltamivir].
A 23-year-old woman had lower abdominal pain, diarrhea and bloody stool was admitted and given a diagnosis of influenza B. Her home doctor had started treatment by neuraminidase inhibitor (oseltamivir) the previous day. Colonoscopic examination revealed an area of hemorrhage and erosion in the left transverse colon. After halting oseltamivir treatment these symptoms disappeared and her colonoscopic findings improved. A drug-induced lymphocyte stimulation test was positive for oseltamivir. This case is the first reported case of acute hemorrhagic colitis induced by oseltamivir.
Yoneda
Satoshi
S
Department of Internal Medicine, Takanohara General Hospital.
Kobayashi
Yozo
Y
Nunoi
Takehiro
T
Takeda
Kosuke
K
Matsumori
Atsushi
A
Andoh
Minoru
M
Tsujinoue
Hirohisa
H
Nishimura
Kimio
K
Fukui
Hiroshi
H
D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D003092:Colitis / Q000139:chemically induced*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D009981:Influenza B virus; D007251:Influenza, Human / Q000188:drug therapy; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir / Q000009:adverse effects*
D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase