title: Animal models of pheochromocytoma including NIH initial experience.
abstract: Mouse models have been used to study the mechanisms underlying the carcinogenesis of a wide variety of human cancer. A considerable number of mouse and rat models, used for the study of elementary tumorgenic mechanisms, were found to develop pheochromocytomas. Some of these models resemble hereditary syndrome-related pheochromocytoma in humans and some may serve as a new starting point for human pheochromocytoma research. Recently, we generated a model of catecholamine-producing metastatic pheochromocytoma in athymic nude mice using tail-vein injection of mouse pheochromocytoma cells (MPCs). This and alternative animal models of metastatic pheochromocytoma are promising avenues in preclinical studies to evaluate new therapeutic approaches for malignant pheochromocytoma.
authors.affiliation: Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, NIH, Building 10, CRC, Room 1E-3141, 10 Center Drive MSC-1109, Bethesda, MD 20892-1109, USA.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ohta
authors.forename: Edwin W
authors.initials: EW
authors.lastname: Lai
authors.forename: Shun'Ichiro
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Tischler
authors.forename: Salvatore
authors.initials: S
authors.lastname: Alesci
authors.forename: Karel
authors.initials: K
authors.lastname: Pacak
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D009316:National Institutes of Health (U.S.); D010673:Pheochromocytoma / Q000473:pathology*; D014481:United States