Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques.
Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous control of SIV in any of these animals could be explained by mutations in host genes. Such variables could confound studies of associations between MHC class I alleles and control of viral replication. We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-alpha, and TSG101 and looked for associations with decreased viral replication. We did not detect any correlations between plasma viral concentration and polymorphisms in host genes examined in this study. In addition, we did not find the polymorphisms present in humans in any of our macaques.
Weiler
Andrea
A
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA. amweiler@wisc.edu
May
Gemma E
GE
Qi
Ying
Y
Wilson
Nancy
N
Watkins
David I
DI
D000818:Animals; D016207:Cytokines / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D056827:Endosomal Sorting Complexes Required for Transport; D005805:Genes, MHC Class I / Q000235:genetics; D006678:HIV / Q000502:physiology*; D008253:Macaca mulatta / Q000235:genetics* / Q000821:virology; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D019707:Receptors, Chemokine / Q000235:genetics; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics*; D015302:Simian Immunodeficiency Virus / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics; D014779:Virus Replication / Q000235:genetics*; D000099177:Tsg101 Protein
D016207:Cytokines; D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D019707:Receptors, Chemokine; D014157:Transcription Factors; D000099177:Tsg101 Protein