title: fRNAdb: a platform for mining/annotating functional RNA candidates from non-coding RNA sequences.
abstract: There are abundance of transcripts that code for no particular protein and that remain functionally uncharacterized. Some of these transcripts may have novel functions while others might be junk transcripts. Unfortunately, the experimental validation of such transcripts to find functional non-coding RNA candidates is very costly. Therefore, our primary interest is to computationally mine candidate functional transcripts from a pool of uncharacterized transcripts. We introduce fRNAdb: a novel database service that hosts a large collection of non-coding transcripts including annotated/non-annotated sequences from the H-inv database, NONCODE and RNAdb. A set of computational analyses have been performed on the included sequences. These analyses include RNA secondary structure motif discovery, EST support evaluation, cis-regulatory element search, protein homology search, etc. fRNAdb provides an efficient interface to help users filter out particular transcripts under their own criteria to sort out functional RNA candidates. fRNAdb is available at http://www.ncrna.org/
authors.affiliation: Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology (AIST) Aomi 2-42, Koto-ku, Tokyo 135-0064, Japan. kin-taushin@aist.go.jp
authors.forename: Taishin
authors.initials: T
authors.lastname: Kin
authors.forename: Kouichirou
authors.initials: K
authors.lastname: Yamada
authors.forename: Goro
authors.initials: G
authors.lastname: Terai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okida
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yoshinari
authors.forename: Yukiteru
authors.initials: Y
authors.lastname: Ono
authors.forename: Aya
authors.initials: A
authors.lastname: Kojima
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Komori
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Asai
mesh_terms: D001483:Base Sequence; D030561:Databases, Nucleic Acid; D023281:Genomics; D020407:Internet; D035683:MicroRNAs / Q000502:physiology; D012333:RNA, Messenger / Q000737:chemistry; D022661:RNA, Untranslated / Q000737:chemistry* / Q000502:physiology; D014584:User-Computer Interface
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D022661:RNA, Untranslated