title: Autopsy case of disseminated Trichosporon inkin infection identified with molecular biological and biochemical methods.
abstract: Trichosporon species are usually opportunistic pathogens. Disseminated trichosporonosis is uncommon but is increasingly reported with a high mortality rate, especially in immunocompromised patients. Although Trichosporon asahii and T. mucoides are known as the most common pathogens of disseminated trichosporonosis, cases of systemic infection due to T. inkin have been reported recently. However, no autopsy case of disseminated T. inkin infection has been reported. Herein is presented an autopsy case of disseminated trichosporonosis caused by T. inkin in a 30-year-old man with allogenic peripheral blood stem cell transplantation for acute myelocytic leukemia. In the present case, identification of T. inkin was performed with morphological, molecular biological and biochemical methods. It is difficult to make a diagnosis of Trichosporon infection on only histological examination; therefore, molecular biological and biochemical methods are needed in a diagnosis of disseminated trichosporonosis.
authors.affiliation: Department of Pathology, St Mary's Hospital, Kurume, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Koyanagi
authors.forename: Naoyo
authors.initials: N
authors.lastname: Nishida
authors.forename: Seishi
authors.initials: S
authors.lastname: Osabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Imamura
authors.forename: Sigeko
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Shichiji
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D001228:Aspergillosis / Q000473:pathology; D001344:Autopsy; D016026:Bone Marrow Transplantation; D004271:DNA, Fungal; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D008172:Lung Diseases, Fungal / Q000473:pathology; D008297:Male; D009181:Mycoses / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D009894:Opportunistic Infections / Q000150:complications* / Q000382:microbiology; D014057:Tomography, X-Ray Computed; D014250:Trichosporon / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal