[Which information should be given to the patient concerning the cardiovascular and renal risk of the NSAIDs?].
OBJECTIVE
Patient information is a topical subject. The aim of this review is to present the rare studies concerning the degree of patient information on the cardiovascular and renal risks of the non-steroidal anti-inflammatory drugs and to suggest some recommendations on this subject.


METHODS
After analysis of the literature (Medline search - January 2006), a series of recommendations has been drown up following discussion among experts from different specialties (clinical epidemiology rheumatology cardiology nephrology gastroenterology).


CONCLUSIONS
It appears necessary to warn all patients of the potential risk of hyperkolemia, renal insufficiency and/or hydrosodium retention (decompensation of an arterial hypertension or a cardiac insufficiency), especially subjects who present risk factors such as age over 75 years, a dehydration, a pre-existing renal disorder etc. Concerning the risk of arterial thrombotic incident (coronary or cerebral), it is important to indicate that this risk is rare and seems to be observed particularly during prolonged treatments and at high dose.
Flipo
René-Marc
RM
Service de Rhumatologie, CHU Roger Salengro, Lille 59000. rmflipo@chru-lille.fr
Héloire
François
F
Deray
Gilbert
G
D000367:Age Factors; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D018849:Controlled Clinical Trials as Topic; D003328:Coronary Thrombosis / Q000139:chemically induced; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced; D006973:Hypertension / Q000139:chemically induced; D020767:Intracranial Thrombosis / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced*; D016239:MEDLINE; D009203:Myocardial Infarction / Q000139:chemically induced; D016017:Odds Ratio; D010353:Patient Education as Topic; D010358:Patient Participation; D051437:Renal Insufficiency / Q000139:chemically induced; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000139:chemically induced; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors