title: Phosphaturic mesenchymal tumor with symptoms related to osteomalacia that appeared one year after tumorectomy.
abstract: A 45-year-old man was admitted to our hospital because of bone pain and hypophosphatemia. He had undergone surgery 2 years previously for a "benign unclassified mesenchymal tumor" in the skull, but there were no clinical symptoms related to osteomalacia. His laboratory examination revealed low serum phosphate, high alkaline phosphatase, and normal calcium levels. The diagnosis of tumor-induced osteomalacia due to phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT) was made by re-examining the pathologic specimens. Oral supplementation with phosphate and 1-25-dihydroxyvitamin D relieved his clinical symptoms and laboratory values returned to normal. However, subcutaneous administration of octreotide had no clinical effect. Clinicians and pathologists should be aware of the existence of PMTMCT especially nonphosphaturic or asymptomatic variants of this disorder.
authors.affiliation: Department of Internal Medicine, Osaka City General Hospital, Osaka.
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Rie
authors.initials: R
authors.lastname: Nagata
authors.forename: Mami
authors.initials: M
authors.lastname: Ueda
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Konishi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hosoi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamanaka
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Iwai
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Sato
mesh_terms: D003388:Cranial Fossa, Posterior / Q000473:pathology* / Q000601:surgery; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000188:drug therapy / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008637:Mesenchymoma / Q000150:complications* / Q000601:surgery / Q000652:urine; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D015282:Octreotide / Q000008:administration & dosage / Q000627:therapeutic use; D010018:Osteomalacia / Q000188:drug therapy / Q000209:etiology* / Q000652:urine; D010710:Phosphates / Q000627:therapeutic use; D016634:Radiosurgery; D019292:Skull Base Neoplasms / Q000150:complications* / Q000601:surgery / Q000652:urine; D014807:Vitamin D / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D010710:Phosphates; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D015282:Octreotide