title: Effect of reduced oxygen concentrations on the outcome of in vitro fertilization.
abstract: We compared the effects of two standard oxygen concentrations, physiological (5% O(2), 5% CO(2), and 90% N(2)) and atmospheric (5% CO(2) with the balance as air), on fertilization, embryo development, and pregnancy rate in 106 patients undergoing IVF, excluding donor oocyte cycles and preimplantation genetic diagnosis cycles. The differences in oxygen concentration did not significantly affect fertilization rate, blastocyst formation, or pregnancy rate, but there was a significant difference in mean embryo score between physiological and atmospheric groups on day 3.
authors.affiliation: School of Medicine, Stanford University, Stanford, California 94305, USA.
authors.forename: Bory
authors.initials: B
authors.lastname: Kea
authors.forename: Janice
authors.initials: J
authors.lastname: Gebhardt
authors.forename: Jill
authors.initials: J
authors.lastname: Watt
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Westphal
authors.forename: Ruth B
authors.initials: RB
authors.lastname: Lathi
authors.forename: Amin A
authors.initials: AA
authors.lastname: Milki
authors.forename: Barry
authors.initials: B
authors.lastname: Behr
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D046509:Tissue Culture Techniques / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D010100:Oxygen