title: [Chromatin modifications during X-chromosome inactivation in female mammals].
abstract: In female mammals, the process of dosage compensation occurs during early embryonic development. As a result of this, one of X-chromosomes becomes transcriptionally inactive. This process is accompanied by chromatin remodeling on inactivated X-chromosome, providing transcriptional silencing of the genes and maintenance of their inactive state. In the present review, the dynamics of modifications occurring during embryonic inactivation, their distribution over the inactive X-chromosome, interaction, and the role in establishing and maintening the inactive state are discussed. As an illustration, modifications on the inactive X-chromosome of the Microtus common vole are presented.
authors.forename: A I
authors.initials: AI
authors.lastname: Shevchenko
authors.forename: S V
authors.initials: SV
authors.lastname: Pavlova
authors.forename: E V
authors.initials: EV
authors.lastname: Dement'eva
authors.forename: D V
authors.initials: DV
authors.lastname: Golubeva
authors.forename: S M
authors.initials: SM
authors.lastname: Zakiian
mesh_terms: D000818:Animals; D003411:Arvicolinae / Q000235:genetics*; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D018899:CpG Islands / Q000235:genetics; D019175:DNA Methylation; D042522:DNA Replication Timing; D005260:Female; D018392:Genomic Imprinting; D006657:Histones / Q000235:genetics / Q000378:metabolism; D051379:Mice; D049951:X Chromosome Inactivation / Q000235:genetics*
chemical_list: D002843:Chromatin; D006657:Histones