Quality of life and depressive symptoms in patients with major depression and end-stage renal disease: a matched-pair study.
OBJECTIVE
To compare the quality of life (QOL) and depressive symptoms of outpatients with major depression with that of nondepressed individuals undergoing hemodialysis (matched for age, gender, and ethnicity).


METHODS
We used the WHOQOL BREF and the Beck Depression Inventory (BDI).


RESULTS
After univariate analyses, depressed patients' QOL scores were significantly lower (P<.0001) in all the assessed domains (i.e., physical health, psychological, social relationships, environmental, and global QOL). Additionally, there was a significant difference in the severity of depression among the study groups (P<.0001). Finally, after multiple regression analysis, the QOL profile of depressed subjects remained significantly worse even when controlling for depression scores and diagnostic status.


CONCLUSIONS
The subjective QOL of patients with major depression is significantly lower than that of subjects undergoing hemodialysis.
Berlim
Marcelo T
MT
Department of Psychiatry and Forensic Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Mattevi
Betina S
BS
Duarte
Anne Paola G
AP
Thomé
Fernando S
FS
Barros
Elvino J G
EJ
Fleck
Marcelo P
MP
D000293:Adolescent; D000328:Adult; D000368:Aged; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000523:psychology*; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010555:Personality Inventory; D011788:Quality of Life / Q000523:psychology*; D006435:Renal Dialysis / Q000523:psychology; D012803:Sick Role; D013223:Statistics as Topic