[Effects of formaldehyde on the activity of superoxide dismutases and glutathione peroxidase and the concentration of malondialdehyde].
This review focus on the effects of formaldehyde on the activity of superoxide dismutases (SOD), glutathione peroxidase (GSH-Px) and the concentration of malondialdehyde (MDA) in recent years. It is showed formaldehyde having effect on lipid peroxidation by many studies of animal experiment and occupational group, it can decrease the activity of SOD and GSH-Px, increase the concentration of MDA, there are dose-response relationship between those lipid peroxidation index and the concentration of formaldehyde too. In future study, the animal experiment and the people's late effect of low dose formaldehyde exposure should be pay more attention.
Chang
Jun-Rui
JR
Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Xu
Dong-Qun
DQ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism*
D005557:Formaldehyde; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase