The HeArt of regeneration.
Fish and amphibian hearts are known to regenerate after partial resection, but the molecular mechanisms underlying this process remain unclear. In this issue of Cell, Lipilina et al. analyze regeneration in the zebrafish heart. Their work indicates that new cardiomyocytes originate from undifferentiated progenitor cells and reveals a critical role for the epicardium, the cellular layer that covers the heart.
Curado
Silvia
S
Department of Biochemistry and Biophysics and the Cardiovascular Research Institute, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA.
Stainier
Didier Y R
DY
D000818:Animals; D030801:Animals, Genetically Modified; D021461:Animals, Outbred Strains; D002454:Cell Differentiation; D006321:Heart / Q000502:physiology*; D006335:Heart Injuries / Q000473:pathology / Q000503:physiopathology; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010496:Pericardium / Q000293:injuries*; D012038:Regeneration / Q000235:genetics / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*; D015027:Zebrafish / Q000235:genetics / Q000502:physiology*