Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration.
Nowadays, drug discovery based on a single-target-directed strategy seems inappropriate for the treatment of complex diseases that have multiple pathogenic factors. Recent research into new drugs, which are able to hit different targets, highlights the idea that a single molecule could be sufficient to treat multi-factorial diseases. In this review, examples of multi-target-directed compounds derived from lipoic acid are examined.
Bolognesi
Maria L
ML
Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Minarini
Anna
A
Tumiatti
Vincenzo
V
Melchiorre
Carlo
C
D000818:Animals; D015195:Drug Design; D006801:Humans; D009410:Nerve Degeneration / Q000188:drug therapy; D018384:Oxidative Stress; D008063:Thioctic Acid / Q000737:chemistry* / Q000627:therapeutic use*
D008063:Thioctic Acid