title: Thymic granulomatous lesions in pigs.
abstract: Rare cases of thymic granulomatous lesions were found in pigs. The lesions consisted of epithelioid cells, multinucleated giant cells, and lymphocytes. Such lesions also were observed in the mesenteric lymph nodes, spleen, kidney, and stomach. The cytoplasm of the majority of giant cells and some epithlioid cells was periodic acid-Schiff (PAS) positive. All cells were positive for vimentin, lysozyme, and desmin. Ultrastructurally, the giant cells were rich in organella and attached to adjacent epithelioid cells by membrane interdigitation. The cells included numerous coated vesicles and granules. No etiologic pathogen, including porcine circovirus type 2, was detected in the lesions. This is the rare case of idiopathic thymic granulomatous lesion in pigs.
authors.affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan. aa27157@mail.ecc.u-tokyo.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: A
authors.initials: A
authors.lastname: Yasoshima
authors.forename: K
authors.initials: K
authors.lastname: Uetsuka
authors.forename: S
authors.initials: S
authors.lastname: Kumagai
authors.forename: K
authors.initials: K
authors.lastname: Doi
mesh_terms: D000818:Animals; D005260:Female; D006099:Granuloma / Q000473:pathology / Q000662:veterinary*; D008206:Lymphatic Diseases / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*; D013950:Thymus Gland / Q000473:pathology*