title: Blood purification for hypercytokinemia.
abstract: Blood purification has been steadily improved in the field of critical care, supported by advances in related biomedical technologies as well as efforts to develop better operating procedures. As it has become clear that hypercytokinemia plays a key role in the pathophysiology of critical pathological conditions, use of various blood purification techniques to control hypercytokinemia has been investigated. Answers to questions concerning the optimal cytokine-removing device (dialyzer/hemofilter/adsorber) as well as operating procedures and conditions of such devices in particular clinical conditions have been obtained in the course of such investigations. The recent success in real-time monitoring of cytokine levels in clinical practice to assess the extent of cytokine network activation may improve the precision and efficacy of blood purification in the treatment of hypercytokinemia. In addition, the recently documented effects of genetic factors on hypercytokinemia suggest that the introduction of tailor-made medicine considering the differences in genetic background among individual patients may improve the efficacy of blood purification as a countermeasure to hypercytokinemia.
authors.affiliation: Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8677, Japan. taka.nakada@nifty.com
authors.forename: Taka-aki
authors.initials: TA
authors.lastname: Nakada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hirasawa
authors.forename: Shigeto
authors.initials: S
authors.lastname: Oda
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Shiga
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Matsuda
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D016207:Cytokines / Q000097:blood* / Q000235:genetics; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics; D015203:Reproducibility of Results; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000628:therapy
chemical_list: D016207:Cytokines