title: Deficits on the Continuous Performance Test within the schizophrenia spectrum and the mediating effects of family history of schizophrenia.
abstract: Individuals with schizophrenia spectrum personality disorders (SSPD) and schizophrenia show similar cognitive impairments. The authors examined the contributions of SSPD symptoms and familial risk for schizophrenia to impairments on the Continuous Performance Test--Identical Pairs Version. Participants included 103 schizophrenia patients, 66 first-degree relatives (29 SSPD), and 103 community controls (26 SSPD) screened for family history of psychosis. Patients and SSPD relatives performed significantly worse than non-SSPD relatives and SSPD and non-SSPD community controls. No differences in performance were observed among non-SSPD relatives and SSPD and non-SSPD community controls. Results suggest a continuum in which risk for schizophrenia-related cognitive impairments is highest among patients and SSPD relatives, intermediate among non-SSPD relatives, and lowest among SSPD and non-SSPD community controls. Results suggest that SSPD in the absence of a family history of psychosis may be a phenocopy.
authors.affiliation: Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA. mavila@mprc.umaryland.edu
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Avila
authors.forename: Olalla
authors.initials: O
authors.lastname: Robles
authors.forename: L Elliot
authors.initials: LE
authors.lastname: Hong
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Blaxton
authors.forename: Carol S
authors.initials: CS
authors.lastname: Myers
authors.forename: Ikwunga
authors.initials: I
authors.lastname: Wonodi
authors.forename: James
authors.initials: J
authors.lastname: Gold
authors.forename: Gunvant K
authors.initials: GK
authors.lastname: Thaker
mesh_terms: D000328:Adult; D001288:Attention; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology; D017008:Negotiating; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*; D012720:Severity of Illness Index