Interactions between HIV-1 Tat and KSHV.
Since the advent of the HIV-1 pandemic, a close association between HIV-1 infection and the development of selected types of cancers has been brought to light. The discovery of Kaposi sarcoma-associated herpesvirus (KSHV) has led to significant advances in uncovering the virological and molecular mechanisms involved in the pathogenesis of AIDS-related malignancies. Extensive evidence indicates that HIV-1 trans-activating protein Tat plays an oncogenic role in the development of KSHV-associated neoplasms. Comprehensive knowledge of the functions of Tat-1 together with the KSHV genes will contribute to a better understanding of the pathogenesis of virus-associated cancers and the interaction of viruses with their hosts.
Aoki
Y
Y
Development, Astellas Pharma Inc., 17-1 Hasune 3-Chome, Itabashi-ku, 174-8612, Japan. yoshiyasu.aoki@jp.astellas.com
Tosato
G
G
D000595:Amino Acid Sequence; D000818:Animals; D015696:Gene Products, tat / Q000737:chemistry / Q000502:physiology*; D015497:HIV-1 / Q000472:pathogenicity*; D015498:HIV-2 / Q000472:pathogenicity; D006801:Humans; D008969:Molecular Sequence Data; D012514:Sarcoma, Kaposi / Q000209:etiology*; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus