title: Dysregulation of retinoid transporters expression in body fluids of schizophrenia patients.
abstract: This study aims to find the biomarkers or associated proteins in body fluids of schizophrenia patients so that we can further understand the etiology of schizophrenia. We applied proteomic technologies combining two-dimensional electrophoresis with Coomassie blue staining and mass spectrometry and identified a procedure for the clinical screening of disease-influenced body fluid proteins in two sets of samples, plasma from 19 schizophrenia patients and cerebrospinal fluid (CSF) from 35 drug-treated schizophrenic patients and 36 healthy controls. The expression of transthyretin (TTR) tetramer increased significantly in plasma of schizophrenic patients after a valid 2 months in-hospital antipsychotic treatment. Conversely, the expression of the TTR tetramer and apolipoprotein E (ApoE) was down-regulated by up to 1.68 and 3.62 times, respectively, in the CSF of schizophrenia patients compared to that of normal controls, which has not been reported previously. Considering that the TTR tetramer and ApoE are both retinoid transporters, retinoid dysfunction might be involved in the pathology of schizophrenia.
authors.forename: Chunling
authors.initials: C
authors.lastname: Wan
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Yang
authors.forename: Huafang
authors.initials: H
authors.lastname: Li
authors.forename: Yujuan
authors.initials: Y
authors.lastname: La
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.forename: Yongshuo
authors.initials: Y
authors.lastname: Chen
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015180:Electrophoresis, Gel, Two-Dimensional; D005786:Gene Expression Regulation; D006801:Humans; D013058:Mass Spectrometry; D008875:Middle Aged; D011228:Prealbumin / Q000302:isolation & purification / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000097:blood / Q000302:isolation & purification / Q000378:metabolism*; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D014150:Antipsychotic Agents; D011228:Prealbumin; D018168:Receptors, Retinoic Acid