Structure-activity delineation of quinones related to the biologically active Calothrixin B.
Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucidate the mechanism of action of the Calothrixins, several related quinones were synthesized and tested for biological activity. The results of the structure-activity relationship (SAR) studies are reported here.
Bernardo
Paul H
PH
Department of Chemistry, Australian National University, Canberra, ACT 0200, Australia.
Chai
Christina L L
CL
Le Guen
Maurice
M
Smith
Geoffrey D
GD
Waring
Paul
P
D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry*; D051379:Mice; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D026121:Indole Alkaloids; D011809:Quinones; C418327:calothrixin B