Testosterone replacement increases vasodilatory reserve in androgen-deficient female rats.
Testosterone replacement leads to increased coronary pressure-induced tone and vasodilatory reserve in oophorectomized rats. The mechanisms involve changes in endothelial nitric-oxide modulation of smooth-muscle constriction and are not a result of the peripheral conversion of T to estrogen.
Cooper
Brian C
BC
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, Vermont, USA. brian-cooper3825@hotmail.com <brian-cooper3825@hotmail.com>
Gokina
Natalia I
NI
Osol
George
G
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000008:administration & dosage*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D000728:Androgens; D013739:Testosterone