title: Exit-site care in peritoneal dialysis.
abstract: Exit-site infection (ESI), tunnel infection and associated peritonitis are major causes of morbidity and catheter loss in chronic peritoneal dialysis patients. Meticulous exit-site care is vital in preventing ESI. Avoiding trauma to the exit-site and daily cleaning of the exit-site with a dedicated antimicrobial soap is essential for the longevity of the peritoneal dialysis catheter. Antibiotics cream and disinfectant agents including povidone-iodine, chlorhexidine, electrolytic chloroxidizing solutions (Amuchina 10% - ExSept Plus, Amuchina 5% - ExSept) are useful to keep the resident micro-organisms inhibited. ESI rates in peritoneal dialysis patients treated with Amuchina 10% (ExSept Plus) and Amuchina 5% (ExSept) for the exit-site care are similar or lower compared to povidone-iodine or chlorhexidine. Electrolytic chloroxidizing (Amuchina 10% - ExSept Plus and Amuchina 5% - ExSept) solutions for exit-site care are effective for prevention and treatment of ESI.
authors.affiliation: Division of Nephrology, Department of Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, N.Y., USA.
authors.forename: Nand K
authors.initials: NK
authors.lastname: Wadhwa
authors.forename: Gampala H
authors.initials: GH
authors.lastname: Reddy
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001458:Bandages; D002408:Catheters, Indwelling / Q000382:microbiology; D002710:Chlorhexidine / Q000627:therapeutic use; D004866:Equipment Contamination / Q000517:prevention & control; D006801:Humans; D006997:Hypochlorous Acid / Q000627:therapeutic use*; D017053:Infection Control / Q000379:methods*; D007676:Kidney Failure, Chronic / Q000628:therapy; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000379:methods*; D010538:Peritonitis / Q000517:prevention & control*; D011206:Povidone-Iodine / Q000627:therapeutic use; D017592:Skin Care / Q000379:methods; D012915:Soaps; D012965:Sodium Chloride / Q000627:therapeutic use*
chemical_list: C057052:Amuchina; D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D012915:Soaps; D012965:Sodium Chloride; D006997:Hypochlorous Acid; D011206:Povidone-Iodine; D002710:Chlorhexidine