title: Association between plasma adiponectin levels and unstable coronary syndromes.
abstract: OBJECTIVE
  Obesity is a risk factor for an acute coronary syndrome (ACS). The association between elevated body mass index (BMI) and ACS is independent of most traditional risk factors, suggesting a possible contribution of other body fat-related mediators. This study evaluated the association between adiponectin and ACS.
  
  
  RESULTS
  Four hundred and ninety-nine patients undergoing coronary angiography were divided into a subgroup without (n = 331) and with ACS (n = 168). In multiple regression analysis, higher adiponectin levels were independently associated with a lower risk of ACS [odds ratio (OR) = 0.61; 95% CIs: 0.46-0.81; P < 0.001]. In contrast, a higher BMI, a history of myocardial infarction, C-reactive protein, and angiographic coronary artery disease severity were all associated with a higher risk. The greatest increase in risk for ACS was seen at adiponectin levels < or = 5.5 microg/mL.
  
  
  CONCLUSIONS
  Higher plasma adiponectin levels are independently associated with a lower risk of ACS.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, 1216 Second Street SW, Rochester, MN 55902, USA. wolk.robert@mayo.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Wolk
authors.forename: Peter
authors.initials: P
authors.lastname: Berger
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Lennon
authors.forename: Emmanouil S
authors.initials: ES
authors.lastname: Brilakis
authors.forename: Diane E
authors.initials: DE
authors.lastname: Davison
authors.forename: Virend K
authors.initials: VK
authors.lastname: Somers
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D052242:Adiponectin / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D011446:Prospective Studies; D012044:Regression Analysis
chemical_list: D052242:Adiponectin; D002097:C-Reactive Protein