Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis.
Capillary electrophoresis was successfully applied for separation of the enantiomers of N-benzyloxycarbonyl-alpha-aminophosphonic and alpha-aminophosphinic acids as well as their ethyl and phenyl monoesters with the use of a range of commercially available cyclodextrins (alpha, beta and hydroxypropyl-gamma-cyclodextrins) as chiral selectors. The dependence of effectiveness of separation on type and concentration of these chiral selectors as well as on pH of background electrolyte was examined in some detail.
Rudzińska
Ewa
E
Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wybrzeze Wyspiańskiego 27, 50-370 Wrocław, Poland.
Poliwoda
Anna
A
Berlicki
Łukasz
Ł
Mucha
Artur
A
Dzygiel
Paweł
P
Wieczorek
Piotr P
PP
Kafarski
Paweł
P
D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D004952:Esters; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D010721:Phosphinic Acids / Q000737:chemistry*; D015203:Reproducibility of Results; D013237:Stereoisomerism
D003505:Cyclodextrins; D004952:Esters; D063065:Organophosphonates; D010721:Phosphinic Acids