title: [The importance of micronization in the design of dosage forms I. Theoretical and biopharmaceutical aspects].
abstract: The role of micronization is growing considering the optimization of the physicochemical characteristics of drug, dissolution enhancement and ensuring appropiate bioavailability. The importance of micronization can be understood on the basis of Noyes-Whitney equation, where the particle characteristics influence the active surface contacting with the dissolution medium, theoretically the solubility, and the boundary layer around the particle under certain hidrodynamic conditions. To adjudge the possibilities and limits of micronization concerning the dosage form design and preparations based on innovative pharmaceutical technology, it is necessary to take the detailed theoretical, physiological and biopharmaceutical aspects into consideration.
authors.affiliation: Semmelweis Egyetem Gyógyszerészeti Intézet, Budapest.
authors.forename: István
authors.initials: I
authors.lastname: Antal
mesh_terms: D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004304:Dosage Forms; D010316:Particle Size; D004364:Pharmaceutical Preparations; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations