The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies.
There is increasing evidence for epistatic interactions between gene products (e.g. KIR) encoded within the Leukocyte Receptor Complex (LRC) with those (e.g. HLA) of the Major Histocompatibility Complex (MHC), resulting in susceptibility to disease. Identification of such associations at the DNA level requires comprehensive knowledge of the genetic variation and haplotype structure of the underlying loci. The LRC haplotype project aims to provide this knowledge by sequencing common LRC haplotypes.
Horton
R
R
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Coggill
P
P
Miretti
M M
MM
Sambrook
J G
JG
Traherne
J A
JA
Ward
R
R
Sims
S
S
Palmer
S
S
Sehra
H
H
Harrow
J
J
Rogers
J
J
Carrington
M
M
Trowsdale
J
J
Beck
S
S
D002874:Chromosome Mapping; D030541:Databases, Genetic; D036281:Genetic Research; D014644:Genetic Variation; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D020407:Internet; D011971:Receptors, Immunologic / Q000145:classification* / Q000235:genetics*; D054340:Receptors, KIR
D011971:Receptors, Immunologic; D054340:Receptors, KIR