title: Protein oxidation and degradation during aging: role in skin aging and neurodegeneration.
abstract: During aging, the products of oxidative processes accumulate and might disturb cellular metabolism. Among them are oxidized proteins and protein aggregates. On the other hand, in a functioning metabolic system oxidized proteins are degraded, mainly by the proteasome. During aging, however, proteasome activity declines. Therefore, the ability to degrade oxidized proteins is attenuated. The following review summarises the accumulation of oxidized proteins and the decline of the proteasomal system during skin and brain aging including some age-related neurodegenerative processes. The role of protein aggregates will be discussed as a potential reason for the accelerated dysfunction of tissue during aging.
authors.affiliation: Research Institute of Environmental Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Widmer
authors.forename: Isabella
authors.initials: I
authors.lastname: Ziaja
authors.forename: Tilman
authors.initials: T
authors.lastname: Grune
mesh_terms: D000375:Aging / Q000502:physiology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism / Q000502:physiology*; D020836:Protein Structure, Quaternary; D011506:Proteins / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000528:radiation effects; D012879:Skin Physiological Phenomena
chemical_list: D016229:Amyloid beta-Peptides; D011506:Proteins; D046988:Proteasome Endopeptidase Complex