title: Epstein-Barr virus in CD30 anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea.
abstract: BACKGROUND
  Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries.
  
  
  OBJECTIVE
  To elucidate the possible association of EBV with CD30+ anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea.
  
  
  METHODS
  In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, paraffin-embedded skin specimens of 26 cases of LyP and 16 cases of CD30+ ALCL involving the skin which were selected from six university hospital medical centers in South Korea.
  
  
  RESULTS
  In situ hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30+ ALCL and in none of the cases of LyP. One EBER-positive case was cutaneous CD30+ ALCL with concurrent lymph node involvement. The other was CD30+ ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP-1 was also positive only for the two cases of EBER-positive CD30+ ALCL.
  
  
  CONCLUSIONS
  LyP and primary cutaneous CD30+ ALCL are very rarely associated with EBV in South Korea.
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea. maychan@ajou.ac.kr
authors.forename: You Chan
authors.initials: YC
authors.lastname: Kim
authors.forename: Woo Ick
authors.initials: WI
authors.lastname: Yang
authors.forename: Min-Geol
authors.initials: MG
authors.lastname: Lee
authors.forename: Soo Nam
authors.initials: SN
authors.lastname: Kim
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Cho
authors.forename: Seok Jong
authors.initials: SJ
authors.lastname: Lee
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
authors.forename: Jai Kyoung
authors.initials: JK
authors.lastname: Koh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D017730:Ki-1 Antigen / Q000032:analysis; D007723:Korea; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology* / Q000821:virology; D017731:Lymphomatoid Papulosis / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000235:genetics; D014763:Viral Matrix Proteins / Q000032:analysis
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex; C037662:EBV-associated membrane antigen, Epstein-Barr virus; C099537:Epstein-Barr virus encoded RNA 1; C106732:Epstein-Barr virus encoded RNA 2; D017730:Ki-1 Antigen; D012367:RNA, Viral; D014763:Viral Matrix Proteins