title: Successful unrelated bone marrow transplantation in a child with chronic granulomatous disease complicated by pulmonary and cerebral granuloma formation.
abstract: We report on a 6-year-old boy with chronic granulomatous disease (CGD) complicated by chronic inflammatory reactions with formation of large pulmonary granuloma as well as intracerebral lesions. Bone marrow transplantation (BMT) from an unrelated donor led to stable reconstitution, to rapid resolution of pulmonary granuloma, and to rapid resolution of intracerebral lesions.
authors.affiliation: Department of Pediatrics, University of Ulm, Eythstrasse 24, 89073 Ulm, Germany.
authors.forename: Catharina
authors.initials: C
authors.lastname: Schuetz
authors.forename: Manfred
authors.initials: M
authors.lastname: Hoenig
authors.forename: Ansgar
authors.initials: A
authors.lastname: Schulz
authors.forename: Min Ae
authors.initials: MA
authors.lastname: Lee-Kirsch
authors.forename: Joachim
authors.initials: J
authors.lastname: Roesler
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Friedrich
authors.forename: Horst
authors.initials: H
authors.lastname: von Bernuth
mesh_terms: D016026:Bone Marrow Transplantation; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D054022:Cerebrum / Q000473:pathology; D002648:Child; D017353:Gene Deletion; D005819:Genetic Markers; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D005819:Genetic Markers