title: Control of absolute helicity in single-stranded abiotic metallofoldamers.
abstract: Described is the design, synthesis, and characterization of abiotic, single-stranded metallofoldamers that adopt helical secondary structures upon metal complexation. The absolute helicity is determined by stereocenters at the ends of the structures and is enforced by the steric influence and hydrogen bonding ability of esters in the backbone of the foldamer. Folding of the structures is characterized in the solid state by X-ray crystallography and in solution by specific rotation, CD spectroscopy, and NMR spectroscopy.
authors.affiliation: Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Dong
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Karpowicz
authors.forename: Shi
authors.initials: S
authors.lastname: Bai
authors.forename: Glenn P A
authors.initials: GP
authors.lastname: Yap
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Fox
mesh_terms: D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008667:Metalloproteins / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D008667:Metalloproteins; D009942:Organometallic Compounds