title: Inflammation, edema, and peripheral blood changes in lung-compromised rats after instillation with combustion-derived and manufactured nanoparticles.
abstract: Increased exposure to pollution has been implicated in cardiovascular malfunction, and although studies show a relationship between PM10 and mortality, the exact biological causes are unclear. This study investigated how compromised lungs respond to instillation of nanoparticles, and the links between exposure to nanoparticles and the subsequent effects on the blood. Instillation of diesel exhaust particles and Cabosil caused significant permeability and inflammatory changes in both bleomycin-treated and control lungs, as shown by increased lung surface protein and lung:body weight ratio. This was true in edematous and maximally repairing lungs, but without significant hematological alterations. Plasma viscosity, a renowned marker for cardiovascular disease, correlated strongly statistically with free cell numbers, type I cell marker rT140, and lung acellular protein. These correlations are a new and novel insight into the mechanisms linking air pollution to cardiovascular mortality.
authors.affiliation: School of Applied Sciences, University of Wales Institute Cardiff, Cardiff, UK. saevans@uwic.ac.uk
authors.forename: Shelley-Ann
authors.initials: SA
authors.lastname: Evans
authors.forename: Ameena
authors.initials: A
authors.lastname: Al-Mosawi
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Adams
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Bérubé
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D001809:Blood Viscosity / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000503:physiopathology; D004195:Disease Models, Animal; D008297:Male; D053758:Nanoparticles / Q000633:toxicity*; D011014:Pneumonia / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D011654:Pulmonary Edema / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020545:Respiratory Mucosa / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D012822:Silicon Dioxide; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D000903:Antibiotics, Antineoplastic; D001335:Vehicle Emissions; D001761:Bleomycin; D012822:Silicon Dioxide