A scaleable and defined system for generating neural stem cells from human embryonic stem cells.
The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.
Joannides
Alexis J
AJ
Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, Cambridge, CB2 2PY United Kingdom.
Fiore-Hériché
Christelle
C
Battersby
Alysia A
AA
Athauda-Arachchi
Pandula
P
Bouhon
Isabelle A
IA
Williams
Lydia
L
Westmore
Kristine
K
Kemp
Paul J
PJ
Compston
Alastair
A
Allen
Nicholas D
ND
Chandran
Siddharthan
S
D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000502:physiology*; D005434:Flow Cytometry; D006801:Humans; D007700:Kinetics; D009474:Neurons / Q000166:cytology* / Q000502:physiology*