title: Engineered internal noise stochastic resonator in gene network: a model study.
abstract: Based on a genetic bistable switch model coupled with a gene oscillator model, we have constructed a mesoscopic stochastic model for the coupled synthetic gene network, and studied how internal noise would influence the oscillation of such a system. We found that the state-to-state transitions can occur if the internal noise is taken into account, and the performance of resulting oscillation can reach a maximum in a certain internal noise level, which indicates the occurrence of internal noise stochastic resonance (SR) and makes the coupled gene network work as a stochastic resonator. The potential role of such an effect on gene expression systems is also discussed.
authors.affiliation: Teda Bio-X Research Center, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, The 13th Avenue of Teda, Tianjin, PR China, 300457.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Wang
authors.forename: Zhonghuai
authors.initials: Z
authors.lastname: Hou
authors.forename: Houwen
authors.initials: H
authors.lastname: Xin
authors.forename: Zhizhou
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D001683:Biological Clocks; D053263:Gene Regulatory Networks; D008957:Models, Genetic; D009991:Oscillometry; D013269:Stochastic Processes; D049490:Systems Biology; D013598:Systems Theory