title: Invasive carcinomas derived from intraductal papillary mucinous neoplasms of the pancreas: a long-term follow-up assessment with CT imaging.
abstract: OBJECTIVE
  To describe computed tomography (CT) findings of invasive carcinoma derived from intraductal papillary mucinous neoplasms (IPMNs) of the pancreas during long-term follow-up.
  
  
  METHODS
  Follow-up CT findings of 5 patients with IPMNs progressing to invasive carcinomas were respectively reviewed for 12 to 63 months. All patients underwent thin-section 3-phase helical and/or multislice CT.
  
  
  RESULTS
  Invasive carcinomas were detected as hypo- (n = 3) or hyperattenuating (n = 2) solid masses in the pancreatic parenchyma on contrast-enhanced CT. Hypoattenuating masses were mostly visualized on arterial dominant phase images. In 4 branch-duct type IPMNs, the solid masses appeared with (n = 3) or without (n = 1) dilatation of the main pancreatic duct after 3 to 5 years. In the remaining combined-type IPMN, a solid mass was detected on initial CT and progressively increased during the follow-up.
  
  
  CONCLUSIONS
  Arterial dominant phase CT is useful for detecting invasive carcinoma derived from IPMNs and is an effective follow-up method.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Oita University Faculty of Medicine, Hasama-machi, Yufu-city 879-5593, Japan. YASUNARI@med.oita-u.ac.jp
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Yamada
authors.forename: Hiromu
authors.initials: H
authors.lastname: Mori
authors.forename: Shunro
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Noritaka
authors.initials: N
authors.lastname: Kamei
authors.forename: Norio
authors.initials: N
authors.lastname: Hongo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed