SUMO-specific proteases and the cell cycle. An essential role for SENP5 in cell proliferation.
Post-translational modification by SUMO is a dynamic and reversible process and several SUMO-specific proteases that remove SUMO from substrates have been identified. We have recently described the activities of a new SUMO-specific protease, SENP5. We found that SENP5 discriminates between SUMO-1 and SUMO-2/3 and cells depleted of SENP5 by RNAi failed to proliferate. Our findings support the idea that differential substrate selection by the mammalian SUMO-specific proteases underlies their regulation of distinct biological processes. Furthermore, our finding of a nonredundant function for SENP5 in cell proliferation provides further support for the model that, analogous to phosphorylation, cycles of SUMOylation and deSUMOylation regulate orderly progression through cell division.
Di Bacco
Alessandra
A
Harvard Medical School Department of Pathology, Boston, Massachusetts 02115, USA.
Gill
Grace
G
D002453:Cell Cycle; D049109:Cell Proliferation; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism / Q000502:physiology*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*
D025841:Small Ubiquitin-Related Modifier Proteins; D010447:Peptide Hydrolases; C512579:Senp5 protein, human