Modafinil and unconstrained motor activity in schizophrenia: double-blind crossover placebo-controlled trial.
Avolition affects quality of life in chronic schizophrenia. We investigated the effect of modafinil upon unconstrained motor activity in 18 male patients. In a randomised crossover design study, wrist-worn actigraphic monitors were used to objectively record motor activity over a 20 h period. Patients' total activity was significantly greater when given the drug. These data suggest that modafinil increases quantifiable motor behaviour in schizophrenia and may have an impact on avolition.
Farrow
Tom F D
TF
SCANLab, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT, UK. t.f.farrow@sheffield.ac.uk
Hunter
Michael D
MD
Haque
Rozana
R
Spence
Sean A
SA
D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D000077408:Modafinil; D009043:Motor Activity / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy*
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D000077408:Modafinil