title: Repeated methamphetamine administration alters expression of the NMDA receptor channel epsilon2 subunit and kinesins in the mouse brain.
abstract: Repeated amphetamine administration results in behavioral sensitization. Behavioral sensitization related to abuse and/or relapse may be associated with stable changes in gene expression. To explore the participating genes, we examined the changes in gene expression levels 24 h or 21 days (long-term withdrawal period) after chronic methamphetamine (METH) treatment for 2 weeks. The expression of several genes related to glutamatergic neural transmission was altered, although changes in the corresponding protein expression were not always consistent with the results for mRNA expression. Of interest, in the frontal cortex of mice treated with METH for 2 weeks, protein expression levels of KIF17 and the N-methyl-D-asparate (NMDA) receptor channel epsilon2 subunit (NRepsilon2) were concomitantly increased. The alteration in expression of these proteins, KIF17 and NRepsilon2, might be a part of the molecular basis of the behavioral sensitization to METH.
authors.affiliation: Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo 156-8585, Japan. yamahide@prit.go.jp
authors.forename: Hideko
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Imai
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kamegaya
authors.forename: Yukio
authors.initials: Y
authors.lastname: Takamatsu
authors.forename: Masashi
authors.initials: M
authors.lastname: Irago
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hagino
authors.forename: Sinya
authors.initials: S
authors.lastname: Kasai
authors.forename: Kiyo
authors.initials: K
authors.lastname: Shimada
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sora
authors.forename: Hisashi
authors.initials: H
authors.lastname: Koga
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology*; D016547:Kinesins / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
chemical_list: D015259:Dopamine Agents; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D008694:Methamphetamine; D016547:Kinesins