[High incidence of fatal cytokine-related disease among children with sequelae of perinatal hypoxic-ischemic encephalopathy].
Children with sequelae of perinatal hypoxic-ischemic encephalopathy (HIE) occasionally suffer from cytokine-related disease. We investigated 12 children with perinatal HIE sequelae, who died in childhood, concerning (1) the incidence of cytokine-related disease as the cause of death, and (2) the characteristics of the cytokine-related disease. Six (50%) of the 12 patients died from cytokine-related disease:two had virus-associated hemophagocytic syndrome (VAHS) ; one had acute encephalopathy;one had systemic inflammatory response syndrome (SIRS); and two had severe pneumonia/acute respiratory distress syndrome (ARDS). These six patients presented with increased liver transaminase, LDH, and CK, and decreased platelet count and albumin. This study shows the high incidence of cytokine-related disease as the cause of death in children with perinatal HIE sequelae. Further investigation is needed to clarify the pathogenesis of this disease.
Suzuki
Motomasa
M
Department of Pediatrics, Okazaki City Hospital, Okazaki, Aichi. moto-su@tb4.so-net.ne.jp
Hayakawa
Fumio
F
Okumura
Akihisa
A
Kato
Toru
T
Kubota
Tetsuo
T
Maruyama
Koichi
K
D001480:Basal Ganglia Diseases / Q000209:etiology; D001925:Brain Damage, Chronic / Q000150:complications*; D016207:Cytokines / Q000097:blood; D004678:Encephalomalacia / Q000209:etiology; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications*; D007226:Infant Mortality; D007231:Infant, Newborn; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D012709:Serum Albumin / Q000032:analysis; D013398:Sudden Infant Death; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*
D016207:Cytokines; D012709:Serum Albumin