Synthesis of the entire framework of tartrolon B utilizing a silicon-tethered ring-closing metathesis strategy.
[Structure: see text] A tandem ring-closing metathesis (RCM) of silaketal-tethered dienynes gives rise to bicyclic siloxanes, which upon removal of the silicon tether afford dienediol skeletons with a stereodefined E,Z-1,3-diene motif. The implementation of this methodology has led to the construction of the entire C1-C21 linear carbon skeleton of tartrolon B.
Kim
Yi Jin
YJ
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.
Lee
Daesung
D
D000900:Anti-Bacterial Agents / Q000737:chemistry; D001881:Borates / Q000138:chemical synthesis; D007783:Lactones / Q000737:chemistry; D015394:Molecular Structure; D012825:Silicon / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D001881:Borates; D007783:Lactones; C092169:tartrolon A; C092170:tartrolon B; D012825:Silicon