ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?
ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in nondividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.
Vallee
Richard B
RB
Deptartment of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA. rv2025@columbia.edu
Varma
Dileep
D
Dujardin
Denis L
DL
D000818:Animals; D001692:Biological Transport; D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism*; D002875:Chromosomes / Q000648:ultrastructure; D003593:Cytoplasm / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology*; D004331:Drosophila melanogaster; D004398:Dyneins / Q000378:metabolism / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D018386:Kinetochores / Q000378:metabolism; D008938:Mitosis; D008954:Models, Biological; D021381:Protein Transport; D008941:Spindle Apparatus
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; C076055:Zw10 protein, Drosophila; D004398:Dyneins