[Advances in the studies of the clearance mechanism of transfused platelet concentrates: review].
Platelet clearance has already been studied in physiological and pathological conditions and shown its occurrence mainly in the liver and the spleen. It is still not clear what mechanisms are responsible for recognition and removal of either aged or damaged platelets by the scavenging system. So study of the clearance mechanism will be useful to prolong the survival time of platelets in vivo. And it may be related to a new strategy to store platelets. This article focuses on the advances in studies of the clearance mechanism of transfused platelet concentrates, including roles of P-selectin, GPI balpha and its receptor Mac-1 in platelet clearance, and effect of endogenous metalloproteinase in platelet clearance.
Guo
Yong
Y
Beijing Institute of Transfusion Medicine, Beijing 100850, China.
Han
Ying
Y
D001792:Blood Platelets / Q000502:physiology*; D001793:Blood Preservation; D016922:Cellular Senescence; D006801:Humans; D016177:Macrophage-1 Antigen / Q000502:physiology; D045726:Metalloproteases / Q000502:physiology; D019007:P-Selectin / Q000502:physiology*; D015539:Platelet Activation; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000502:physiology*; D017713:Platelet Transfusion
D016177:Macrophage-1 Antigen; D019007:P-Selectin; D019038:Platelet Glycoprotein GPIb-IX Complex; C023592:glycocalicin; D045726:Metalloproteases