Myb proteins inhibit fibroblast transformation by v-Rel.
Genes that cause cancer have been divided into two general classes--oncogenes that act in a dominant fashion to transform normal cells into a malignant state, and tumor suppressor genes that act in a dominant fashion to prevent such transformation. In this report, we demonstrate that both the v-myb retroviral oncogene, which causes leukemic transformation of hematopoietic cells, and the c-myb proto-oncogene can also function as inhibitors of fibroblast transformation by the v-rel oncogene. These results imply that the myb genes can function either as oncogenes or as tumor suppressors in different cellular contexts.
Fu
Shu-Ling
SL
Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA. slfu@ym.edu.tw
Ganter
Brigitte
B
Lipsick
Joseph S
JS
D000199:Actins / Q000378:metabolism; D000818:Animals; D002457:Cell Extracts; D002467:Cell Nucleus / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D005347:Fibroblasts / Q000166:cytology / Q000473:pathology*; D051379:Mice; D020626:Oncogene Proteins v-myb / Q000235:genetics / Q000378:metabolism*; D020572:Oncogene Proteins v-rel / Q000378:metabolism*; D020598:Proto-Oncogene Proteins c-myb / Q000235:genetics / Q000378:metabolism*; D011533:Proviruses / Q000235:genetics; D011784:Quail; D011960:Receptors, Estrogen / Q000378:metabolism
D000199:Actins; D002457:Cell Extracts; D020626:Oncogene Proteins v-myb; D020572:Oncogene Proteins v-rel; D020598:Proto-Oncogene Proteins c-myb; D011960:Receptors, Estrogen