title: The amino acid sequence of an AL-protein, AL-KH, isolated from the heart of a patient with Waldenstroms macroglobulinemia and amyloidosis.
abstract: An AL-protein was isolated from the myocardium of a patient (KH) with Waldenstrom's macroglobulinemia. SDS-PAGE of the fraction revealed three major bands ranging from 14 to 30 kDa. Two of the major bands showed a positive PAS test for carbohydrate. The amino acid sequence was established for positions 1-92 and for positions 104-205, except for 150-187. According to the data, the AL-protein KH is derived from the kappa 1c germline gene.
authors.affiliation: Department of Biochemistry/Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway.
authors.forename: Sissel
authors.initials: S
authors.lastname: Kjaeraas
authors.forename: Gunnar
authors.initials: G
authors.lastname: Husby
authors.forename: Knut
authors.initials: K
authors.lastname: Sletten
mesh_terms: D000368:Aged; D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D000686:Amyloidosis / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009206:Myocardium / Q000378:metabolism*; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000235:genetics / Q000378:metabolism*
chemical_list: D000682:Amyloid; C035222:amyloid protein AL