title: Single-shot quantitative perfusion imaging of the human lung.
abstract: The major drawback to quantitative perfusion imaging using arterial spin labeling (ASL) techniques is the need to acquire two images (tag and control), which must be subtracted in order to obtain a perfusion-weighted image. This can potentially result in misregistration artifacts, especially in lung imaging, due to varying lung inflation levels in different breath-holds. In this work a double inversion recovery (DIR) imaging technique that yields perfusion-weighted images of the human lung in a single shot is presented. This technique ensures the complete suppression of background tissue while it preserves signal from the blood. Furthermore, the perfusion-weighted images and an additional (independent) acquired reference scan can be used to obtain quantitative perfusion information from the lungs.
authors.affiliation: Department of Experimental Physics 5, University of Wuerzburg, Wuerzburg, Germany. edpracht@physik.uni-wuerzburg.de
authors.forename: Eberhard D
authors.initials: ED
authors.lastname: Pracht
authors.forename: André
authors.initials: A
authors.lastname: Fischer
authors.forename: Johannes F T
authors.initials: JF
authors.lastname: Arnold
authors.forename: Markus
authors.initials: M
authors.lastname: Kotas
authors.forename: Michael
authors.initials: M
authors.lastname: Flentje
authors.forename: Peter M
authors.initials: PM
authors.lastname: Jakob
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology* / Q000098:blood supply*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D013113:Spin Labels
chemical_list: D003287:Contrast Media; D013113:Spin Labels