title: Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads.
abstract: Complementary diaminopyridine (DAP) and flavin derivatives self-assemble into discrete helically stacked tetrads in hydrocarbon solvents. The self-assembled structure was demonstrated through induced circular dichroism using DAPs with chiral side-chains and flavin with achiral side-chains. Flavin derivatives with chiral side-chains were synthesized; cooperativity in the self-assembly was established through circular dichroism (CD) profiles and melting curves. It was found that placing stereocenters in both recognition units resulted in a strong bisignated profile and enhancement of complex stability, indicative of cooperative self-assembly.
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakade
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Jordan
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.forename: Sudhanshu
authors.initials: S
authors.lastname: Srivastava
authors.forename: Rochelle R
authors.initials: RR
authors.lastname: Arvizo
authors.forename: Graeme
authors.initials: G
authors.lastname: Cooke
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism