title: Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity.
abstract: The immune system has evolved to tolerate what is self and reject what is foreign. The recognition of self from non-self is performed by activating and inhibitory receptors, which signal immune cells via adapter molecules, determining the outcome of the immune response. DAP10, a transmembrane adapter protein expressed broadly in hematopoietic cells, associates with NKG2D activating receptor forming a multisubunit complex, which recognizes self-proteins upregulated during tumorigenesis, infection, and autoimmune response. Analysis of immune reactions against syngeneic tumors, as well as autoimmune responses in the DAP10-deficient mice, revealed an important physiological role of DAP10 signaling in maintaining tolerance to self, probably by controlling the development and activation threshold of autoreactive T cells.
authors.affiliation: Cellular Immunology Laboratory, Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research, Inc.), Palo Alto, CA 94304, USA.
authors.forename: Nevila
authors.initials: N
authors.lastname: Hyka-Nouspikel
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Phillips
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000502:physiology*; D017634:Self Tolerance / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
chemical_list: D001324:Autoantigens; C492355:Hcst protein, mouse; D008565:Membrane Proteins; D011971:Receptors, Immunologic