[Principles of the immune modulation therapy against papilloma virus infections].
The aim of the study was to investigate the effect of Immudone on local immune responses of cervical mucous in patients with papilloma virus cervicitis. 80 women of reproductive age with chronic cervicitis, 60 women with no signs of infection and 70 bioptates obtained from the base of vaginal section of the cervix. Colposcopic, bacterioscopic, patho-histological and immunohistochemical investigations have been performed. After using of Immudone healing of ectopia was observed in the most of cases. As a result of local application of Immudone in patients with PVI in the tissue of cervix the rate of CD4+ cells was increased, expression of receptors of interleukin-2 was increased, CD4/CD8 ratio also increased, quantity of macrophages and natural killers was increased. Local sIgA synthesis was restored.
Kamladze
P O
PO
Mamamgavrishvili
I D
ID
Kintraia
N P
NP
D000282:Administration, Intravaginal; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000942:Antigens, Bacterial / Q000627:therapeutic use*; D015703:Antigens, CD / Q000276:immunology; D000946:Antigens, Fungal / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000188:drug therapy* / Q000821:virology*; D013849:Thimerosal / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000209:etiology*
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D015703:Antigens, CD; D000946:Antigens, Fungal; D004338:Drug Combinations; C011874:imudon; D013849:Thimerosal