title: [Preparation of puerarin solid self-microemulsion].
abstract: OBJECTIVE
  To prepare puerarin solid self-microemulsifying drug delivery system (SMEDDS).
  
  
  METHODS
  Pseudo-ternary phase diagram was used to select the formula of microemulsion. The self-microemulsification efficiency was assessed, such as viscosity, conductance, refraction, zeta potential, size ditribution, dissolution were investigated. Puerarin were determined by UV to calculate the cumulative release at different time.
  
  
  RESULTS
  The optimum formulation of puerarin solid self-microemulsifying drug delivery system the consisted of puerarin-Tween 800 glycerinum-ethyl oleate-water-Gum Acacia-manicol at weight ratio of 1.7: 16. 6: 16. 6: 16. 6 : 1.3: 4.0: 39.9: 19.9; Average particle diameter was 30 nm; The dissolution was 94.29% at 10 min.
  
  
  CONCLUSIONS
  Stability of puerarin solid self-microemulsion drug delvery system is good, potent in improving the dissolution of puerarin.
authors.affiliation: College of Pharmacy, Shandong University, Jinan 250012, China. yuaihua@sdu.edu.cn
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Yu
authors.forename: Guang-Xi
authors.initials: GX
authors.lastname: Zhai
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D001682:Biological Availability; D016503:Drug Delivery Systems / Q000379:methods; D004355:Drug Stability; D004655:Emulsions; D007529:Isoflavones / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water
chemical_list: D004655:Emulsions; D007529:Isoflavones; D013501:Surface-Active Agents; D014867:Water; C033607:puerarin