title: Effects of long-term use of the heat-clearing, diuresis-promoting and collateral-mediating chinese drugs on changes of proteinuria in patients with chronic nephritis.
abstract: OBJECTIVE
  To observe and evaluate the effects of long-term use of the heat-clearing, diuresis-promoting and collateral-mediating Chinese drugs on changes of proteinuria in patients with chronic nephritis, to analyze the influence of renal function, blood pressure, proteinuria and TCM syndrome types on therapeutic effects of the therapy, and to analyze the indications and effects of the heat-clearing, diuresis-promoting and collateral-mediating Chinese drugs when added with small dosage of Lei Gong Teng ([Chinese characters: see text] Radix et Rhizoma Tripterygii).
  
  
  METHODS
  43 cases of chronic nephritis were treated for one year with the heat-clearing, diuresis-promoting and collateral-mediating Chinese drugs.
  
  
  RESULTS
  A one-year treatment showed obvious reduction of proteinuria in patients with chronic nephritis.
  
  
  CONCLUSIONS
  (1) The heat-clearing, diuresis-promoting and collateral-mediating Chinese drugs are effective for a long-term treatment of proteinuria in patients with chronic nephritis. (2) Additional use of Lei Gong Teng can help control proteinuria. (3) Damp-heat deeply accumulated in the kidney is one of the pathologic characteristics for chronic nephritis with the damp-heat syndrome.
authors.affiliation: Nanjing University of Traditional Chinese Medicine, Nanjing 210036, China.
authors.forename: Zou
authors.initials: Z
authors.lastname: Xi
authors.forename: Xiong
authors.initials: X
authors.lastname: Ningning
mesh_terms: D000328:Adult; D002908:Chronic Disease / Q000188:drug therapy; D003097:Collateral Circulation / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000150:complications*; D011507:Proteinuria / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal