Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells.
Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells.
Baráth
Zoltán
Z
Institute of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Szeged, Hungary.
Radics
Rita
R
Spengler
Gabriella
G
Ocsovszki
Imre
I
Kawase
Masami
M
Motohashi
Noboru
N
Shirataki
Yoshiaki
Y
Shah
Anamik
A
Molnár
József
J
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002867:Chromones / Q000737:chemistry / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D019450:Genes, MDR; D006801:Humans; D016399:Lymphoma, T-Cell / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D014162:Transfection
D002867:Chromones; C502480:formylchromone