title: SUMO-specific proteases and the cell cycle. An essential role for SENP5 in cell proliferation.
abstract: Post-translational modification by SUMO is a dynamic and reversible process and several SUMO-specific proteases that remove SUMO from substrates have been identified. We have recently described the activities of a new SUMO-specific protease, SENP5. We found that SENP5 discriminates between SUMO-1 and SUMO-2/3 and cells depleted of SENP5 by RNAi failed to proliferate. Our findings support the idea that differential substrate selection by the mammalian SUMO-specific proteases underlies their regulation of distinct biological processes. Furthermore, our finding of a nonredundant function for SENP5 in cell proliferation provides further support for the model that, analogous to phosphorylation, cycles of SUMOylation and deSUMOylation regulate orderly progression through cell division.
authors.affiliation: Harvard Medical School Department of Pathology, Boston, Massachusetts 02115, USA.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Di Bacco
authors.forename: Grace
authors.initials: G
authors.lastname: Gill
mesh_terms: D002453:Cell Cycle; D049109:Cell Proliferation; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism / Q000502:physiology*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins; D010447:Peptide Hydrolases; C512579:Senp5 protein, human