title: Genome sequences of two frog herpesviruses.
abstract: The sequences of two frog herpesviruses, Ranid herpesvirus 1 and Ranid herpesvirus 2, were determined. They are respectively 220 859 and 231 801 bp in size and contain 132 and 147 predicted genes. The genomes are related most closely in the central regions, where 40 genes are conserved convincingly. Nineteen of these genes are also conserved in a fish herpesvirus, Ictalurid herpesvirus 1. The terminal regions of the genomes are largely not conserved and contain many of the 15 families of related genes present in each genome. The frog herpesviruses are unique among sequenced herpesviruses in that the three exons of the gene encoding the putative ATPase subunit of terminase are not specified by the same DNA strand and in that they encode a putative DNA (cytosine-5-)-methyltransferase and have extensively methylated genomes.
authors.affiliation: MRC Virology Unit, Church Street, Glasgow G11 5JR, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Davison
authors.affiliation: MRC Virology Unit, Church Street, Glasgow G11 5JR, UK.
authors.forename: Charles
authors.initials: C
authors.lastname: Cunningham
authors.affiliation: Beethoven Strasse 35, 35510 Butzbach, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Sauerbier
authors.affiliation: Department of Genetics, Cell Biology and Development, University of Minnesota, Saint Paul, MN 55108, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: McKinnell
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics; D019175:DNA Methylation; D004279:DNA, Viral / Q000737:chemistry* / Q000235:genetics; D004706:Endodeoxyribonucleases / Q000235:genetics; D005091:Exons; D005814:Genes, Viral; D016679:Genome, Viral; D006564:Herpesviridae / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D011898:Ranidae / Q000821:virology; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D004279:DNA, Viral; D004248:DNA (Cytosine-5-)-Methyltransferases; D004706:Endodeoxyribonucleases; C030894:terminase; D000251:Adenosine Triphosphatases