title: Response to influenza vaccine in people with non-protective HI antibody titers.
abstract: The purpose of the study was to determine which factors correlate directly with response to vaccination in such a group of subjects with non-protective HI antibody titers before vaccination. Two vaccines were used, a subunit virus vaccine adjuvanted with MF59 and a split virus vaccine. The analysis indicated that immunization with vaccine adjuvanted with MF59 was an independent variable for immune response against A/H3N2 (OR: 3.51; 95% CI: 1.81-6.79) and B (OR: 2.31; 95% CI: 1.37-3.89). The results suggest that antibody response to vaccine is satisfactory in elderly people previously lacking a protective antibody titer, and that the adjuvanted vaccine reveals a better immunogenicity.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Baldo
authors.forename: Tatjana
authors.initials: T
authors.lastname: Baldovin
authors.forename: Annarosa
authors.initials: A
authors.lastname: Floreani
authors.forename: Michele
authors.initials: M
authors.lastname: Minuzzo
authors.forename: Renzo
authors.initials: R
authors.lastname: Trivello
mesh_terms: D000276:Adjuvants, Immunologic; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000096:biosynthesis*; D004311:Double-Blind Method; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D022223:Vaccines, Subunit