title: Impact of FDG-PET/MRI image fusion on the detection of pancreatic cancer.
abstract: BACKGROUND
  This study assessed the value of image fusion with (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients suspected of having pancreatic cancer.
  
  
  METHODS
  32 patients (12 women, 20 men; age 24-79 years; mean 56.6 years) were included. All patients underwent whole-body FDG-PET examinations and contrast-enhanced MRI. Image fusion used a semiautomatic voxel-based algorithm. Separate reading, side-by-side analysis and evaluation of fused PET/MRI images were performed. Results were correlated to histopathology (n = 30), or clinical follow-up (n = 2).
  
  
  RESULTS
  15/32 patients had pancreas cancer and 17/32 patients benign disease. The sensitivity and specificity for cancer detection by FDG-PET were 93 and 41% for visual and 86 and 58% for semiquantitative analysis whereas MRI achieved 100 and 76% respectively. Topographical assignment of PET foci by image fusion was superior to side-by-side analysis in 11/39 (28%) foci (in 8/32 patients). However, a true impact on therapeutic strategy was observed only in 1/8 patients as the presence of multiple metastases, irresectable primaries or medical reasons for inoperability prevented a curative setting.
  
  
  CONCLUSIONS
  Compared to side-by-side analysis, PET/MRI image fusion improves the anatomical assignment and interpretation of FDG foci. The therapeutic benefit for the patient however is limited in patients with multiple lesions or incurable primaries.
authors.affiliation: Klinik fur Strahlenheilkunde, Charité Universitatsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Ruf
authors.forename: E
authors.initials: E
authors.lastname: Lopez Hänninen
authors.forename: M
authors.initials: M
authors.lastname: Böhmig
authors.forename: I
authors.initials: I
authors.lastname: Koch
authors.forename: T
authors.initials: T
authors.lastname: Denecke
authors.forename: M
authors.initials: M
authors.lastname: Plotkin
authors.forename: J
authors.initials: J
authors.lastname: Langrehr
authors.forename: B
authors.initials: B
authors.lastname: Wiedenmann
authors.forename: R
authors.initials: R
authors.lastname: Felix
authors.forename: H
authors.initials: H
authors.lastname: Amthauer
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000556:secondary; D000328:Adult; D000368:Aged; D003537:Cystadenoma / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012189:Retrospective Studies
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18