title: [Central congenital hypothyroidism due to Graves' disease in the mother].
abstract: Two male twins were born at a gestational age of 30 weeks. Five days after delivery, the mother was diagnosed with Graves' disease. The thyroid function in the neonates was therefore evaluated, which led to the detection of central congenital hypothyroidism (central CHT), even though the neonatal CHT-screening had been reported to be normal. Both boys were treated with thyroxine up to the age of nine months. It was then established that their development had been uneventful. Maternal Graves' disease can, due to the presence of anti-thyroid stimulating hormone (TSH) receptor antibodies and the maternal use of anti-thyroid drugs, result in thyroid dysfunction in the neonate. Neonates born to mothers with Graves' disease are at risk of developing central CHT. This occurs especially in children of mothers who are not treated or are inadequately treated during pregnancy. In view of the importance of thyroid hormone for brain development, children with central CHT are at risk for neurodevelopmental problems if thyroid dysfunction is not detected and treated early. The Dutch screening for congenital hypothyroidism is based on thyroxine (T4), TSH and thyroid-binding globulin. This makes it possible to detect central CHT. However, in prematurely born infants this disease may be missed because in this subgroup, referral is only based on increased TSH levels, which may not be present.
authors.affiliation: Universitair Medisch Centrum St. Radboud, Huispost 833, Postbus 9101, 6500, HB Nijmegen. c.liebrand@cukz.umcn.nl
authors.forename: C A
authors.initials: CA
authors.lastname: Liebrand
authors.forename: A C
authors.initials: AC
authors.lastname: de Mol
authors.forename: M J E
authors.initials: MJ
authors.lastname: Kempers
authors.forename: C
authors.initials: C
authors.lastname: Noordam
mesh_terms: D000328:Adult; D003409:Congenital Hypothyroidism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004200:Diseases in Twins / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use*; D016896:Treatment Outcome; D014427:Twins
chemical_list: D013963:Thyroid Hormones; D013974:Thyroxine