Prevention trials in Alzheimer disease: one step forward?
Finding strategies that prevent or delay the onset of dementia in Alzheimer disease (AD) will be a challenge for the years to come. Prevention trials in AD pose several unresolved questions, including methodologic, scientific, medical, regulatory, and ethical issues. A critical concern is the benefit and relative risk of giving a treatment to non-demented patients or to asymptomatic subjects. Some trials are under way and will perhaps move the field of prevention of dementia one big step forward.
Touchon
J
J
Neurology Service, Guy de Chauliac Hospital, Montpellier, France. jacques.touchon@wanadoo.fr
Portet
F
F
Gauthier
S
S
D000544:Alzheimer Disease / Q000517:prevention & control; D006801:Humans; D011322:Primary Prevention / Q000379:methods* / Q000639:trends; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000639:trends