Traceless solid-phase synthesis of substituted xanthines.
A traceless solid-phase route to substituted xanthines, based on the late-stage pyrimidine ring closure, has been developed. This method is especially useful for the preparation of xanthines containing a variety of substituents at the N1, N3, N7, and C8 positions in an unambiguous manner. A representative set of 22 compounds was prepared.
He
Rongjun
R
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Ching
Shi Min
SM
Lam
Yulin
Y
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism; D014970:Xanthines / Q000138:chemical synthesis* / Q000737:chemistry
D012996:Solutions; D014970:Xanthines