title: [Investigation for proper use of probiotics in Nagasaki University Hospital of Medicine and Dentistry].
abstract: Antimicrobial agents sometimes cause the adverse effects of diarrhea and loose stool. Antibiotic-resistant lactic acid bacteria are used to prevent these adverse effects. The bacteria are not resistant to several antimicrobial agents, although the bacterium preparations are sometimes prescribed the antimicrobial agents concomitantly. Therefore this paper reports that the minimal inhibitory concentration of three new antimicrobial agents against antibiotic-resistant lactic acid bacteria were determined using a microdilution method with cation-adjusted Mueller-Hinton broth. Furthermore, we investigated antimicrobial agents that are prescribed concomitantly with antibiotic-resistant lactic acid bacterium preparations or a clostridium butyricum preparation. The bacteria were susceptible to the three new antimicrobial agents. Approximately 50% of the bacterium preparations were prescribed alone, and 30% were prescribed concomitantly with antimicrobial agents that show antimicrobial activity against the bacteria. Consequently, we suggest that pharmacists need to confirm prescriptions and to provide more drug information on antibiotic-resistant lactic acid bacterium preparations.
authors.affiliation: Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry, 1-7-1 Sakamoto, Nagasaki City 852-8501, Japan. kanoko-kyu@umin.ac.jp
authors.forename: Kanoko
authors.initials: K
authors.lastname: Egashira
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitahara
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kashiwagi
authors.forename: Norihide
authors.initials: N
authors.lastname: Higuchi
authors.forename: Mikiro
authors.initials: M
authors.lastname: Nakashima
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ichikawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004346:Drug Information Services; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D004363:Drug Utilization / Q000706:statistics & numerical data*; D013293:Enterococcus faecalis / Q000187:drug effects*; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D019936:Probiotics / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents