Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats.
Using a conditioned place paradigm, we examined the involvement of the bed nucleus of the stria terminalis (BST) in the negative affective component of visceral and somatic pain induced by intraperitoneal acetic acid and intraplantar formalin injections, respectively, in rats. Bilateral BST lesions suppressed both the acetic acid- and formalin-induced conditioned place aversion, suggesting the crucial role of the BST in the negative affective component of visceral and somatic pain.
Deyama
Satoshi
S
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Nakagawa
Takayuki
T
Kaneko
Shuji
S
Uehara
Takashi
T
Minami
Masabumi
M
D019342:Acetic Acid; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal; D003213:Conditioning, Psychological; D005557:Formaldehyde; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D010147:Pain Measurement / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D012686:Septal Nuclei / Q000293:injuries / Q000503:physiopathology*; D013997:Time Factors
D005557:Formaldehyde; D019342:Acetic Acid