[Diagnosis and treatment of thyroid cancer in children in the multicenter analysis in Poland for PPGGL].
BACKGROUND
Differentiated thyroid carcinoma (DTC) in children presents different biological behavior in comparison to adults. Authors presents preliminary results of multicenter analysis concerning incidence, diagnostics and treatment of DTC in children.


METHODS
The study is a retrospective analysis of 107 pediatric patients from 14 academic centers based on the data from 2000 to 2005 obtained by questionnaire in hospitals involved in the treatment of DTC in children.


RESULTS
Papillary thyroid cancer was diagnosed in 83 children, follicular thyroid cancer in 10 children and medullary thyroid cancer in 14 children. Incidence of DTC in children was estimated between 18 and 23 cases per year. The biggest group of patients consisted of children between 11 and 15 years of age, with girls to boys ratio 3.3 : 1. Clinically DTC in children presented most often as solitary thyroid nodule. Cervical lymphadenopathy was observed in 42% of patients. Intraoperative verification indicated metastatic nodes in 50% of children. Low stage DTC predominated (T1 in 36% and T2 in 26% of children). One step surgery was performed in 65% of children with DTC, two step surgery in 25% of patients. I131 therapy was undertaken in 80% of children. Lung metastases were indicated in post therapeutic studies in 14% of children with DTC. Prophylactic thyroidectomies were performed in 79% of children in the group of patients with MTC and RET gene mutations.


CONCLUSIONS
The necessity of introduction of unified therapeutic standard in children with DTC in Poland is underlined.
Prokurat
Andrzej I
AI
Department of Pediatric Surgery Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum-Bydgoszcz, M. Skłodowskiej-Curie 9, Bydgoszcz. aprokurat@cm.umk.pl
Chrupek
Małgorzata
M
Pacholska
Małgorzata
M
Gałazka
Przemysław
P
Harasymczuk
Jerzy
J
Jankowski
Andrzej
A
Niedziela
Marek
M
Korman
Eugeniusz
E
Kozłowicz-Gudzińska
Izabella
I
Czetwertyńska
Małgorzata
M
Kaliciński
Piotr
P
Polnik
Dariusz
D
Starzyk
Jerzy
J
Kalicka-Kasperczyk
Alicja
A
Czernik
Jerzy
J
Sawicz-Birkowska
Krystyna
K
Bagłaj
Maciej
M
Balcerska
Anna
A
Stefanowicz
Joanna
J
Birkholz
Dorota
D
Pomorski
Lech
L
Kaczka
Krzysztof
K
Peregud-Pogorzelski
Jarosław
J
Petriczko
Elżbieta
E
Godziński
Jan
J
Ptaszyńska
Joanna
J
Ziemniak
Barbara
B
Woźniak
Wojciech
W
Bilska
Katarzyna
K
Górska
Maria
M
Zonenberg
Anna
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*