title: Tensile strength and host response towards silk and type i polypropylene implants used for augmentation of fascial repair in a rat model.
abstract: OBJECTIVE
  We compared host response, architectural integration and tensile strength of two different macroporous silk constructs to a polypropylene type I implant in a rat model for augmentation of primary fascial defect repair.
  
  
  METHODS
  Animals were sacrificed on days 7, 14, 30 and 90 after implantation. The explants were evaluated macroscopically for infections, herniations and adhesions, mechanically for tensile strength, and histopathologically, to evaluate collagen deposition and inflammatory response.
  
  
  RESULTS
  The tensile strength of the explants showed a gradual increase for all materials. All implants uniformly shrank around one fifth by 90 days. In the silk implants, the inflammatory reaction showed a remarkable higher number of foreign body giant cells that characteristically spread from the periphery into implants. Collagen deposition was comparable for all the materials. In Silk a higher grade of neovascularisation was observed.
  
  
  CONCLUSIONS
  Silk explants expressed high tensiometric strength, which was associated with a marked fibrotic process. The silk implants induced a strong foreign body reaction accompanied by microscopic signs of architectural degradation at 90 days. Polypropylene explants showed a more moderate foreign body reaction without architectural disturbance.
authors.affiliation: Centre for Surgical Technologies, Faculty of Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Federico
authors.initials: F
authors.lastname: Spelzini
authors.forename: Maja L
authors.initials: ML
authors.lastname: Konstantinovic
authors.forename: Isabelle
authors.initials: I
authors.lastname: Guelinckx
authors.forename: Godelieve
authors.initials: G
authors.lastname: Verbist
authors.forename: Erik
authors.initials: E
authors.lastname: Verbeken
authors.forename: Dirk
authors.initials: D
authors.lastname: De Ridder
authors.forename: Jan
authors.initials: J
authors.lastname: Deprest
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000071938:Fasciotomy; D005260:Female; D005549:Foreign-Body Reaction / Q000453:epidemiology; D006801:Humans; D008297:Male; D008422:Materials Testing / Q000379:methods*; D011126:Polypropylenes / Q000276:immunology* / Q000627:therapeutic use; D019736:Prostheses and Implants; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D013718:Tensile Strength; D014596:Uterine Prolapse / Q000601:surgery; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes