title: The use of oxygen in Fournier's gangrene.
abstract: Fournier's gangrene is an aggressive form of necrotizing fasciitis of the perineal, perianal or genital regions, usually caused by a polymicrobial infection that includes virulent organisms. Over the last decades, we have treated 9 patients suffering from Fournier's gangrene using systemic chemotherapy with broad-spectrum antibiotics, and with extensive, sometimes serial surgical debridement. Recently in one case, in addition to treatment, we used locally 100% oxygen in daily doses with promising results in healing wound. Herein, we report this case with a brief review of the literature concerning pathogenesis, risk factors, and treatment approaches.
authors.affiliation: 2nd Propedeutic Department of General Surgery, Medical School, University of Athens, Laiko General Hospital, Athens, Greece. diabahmad1@yahoo.gr
authors.forename: Michael C
authors.initials: MC
authors.lastname: Safioleas
authors.forename: Michael C
authors.initials: MC
authors.lastname: Stamatakos
authors.forename: Ahmad I
authors.initials: AI
authors.lastname: Diab
authors.forename: Panagiotis M
authors.initials: PM
authors.lastname: Safioleas
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use; D001458:Bandages; D003646:Debridement; D018934:Fournier Gangrene / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D010100:Oxygen / Q000008:administration & dosage*; D010502:Perineum / Q000293:injuries / Q000601:surgery; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000627:therapeutic use; D013307:Streptomycin / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D008795:Metronidazole; D011206:Povidone-Iodine; D010100:Oxygen; D013307:Streptomycin