[Regulatory mechanisms of mammalian imprinting].
Epigenetic modifications, such as monoallelic DNA methylation, covalent histone modifications, nonhistone proteins, chromatin folding, heterochromatinization, spatial nucleus organization are reviewed with regard to establishment and maintenance of imprinting in mammals. Special attention is paid to repeated DNA sequences as intermediates of the above epigenetic modifications. A suggestion is put forward relative to importance of preimplantation development, in particular, to chromosome organization and segregation in the establishment of imprinting. Some futher directions of imprinting mechanisms are also discussed.
Patkin
E L
EL
Suchkova
I O
IO
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D020090:Chromosome Segregation; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000235:genetics; D019175:DNA Methylation; D004261:DNA Replication; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005786:Gene Expression Regulation; D016678:Genome; D018392:Genomic Imprinting; D006657:Histones / Q000235:genetics; D008322:Mammals / Q000235:genetics* / Q000254:growth & development; D017510:Protein Folding; D012326:RNA Splicing; D014158:Transcription, Genetic
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D004247:DNA; D012321:DNA-Directed RNA Polymerases