Levels of vascular cell adhesion molecule-1 and endothelin-1 in ischemic stroke: a longitudinal prospective study.
OBJECTIVE
To determine levels of vascular cellular adhesion molecule (VCAM)-1 and endothelin (ET)-1 in patients with stroke.


METHODS
Thirty-four patients were prospectively studied. Plasma levels of VCAM-1 and ET-1 were measured by ELISA within 72 h of the event, at 7 and 90 days.


RESULTS
Levels of VCAM-1 increased overtime, whereas ET-1 values were initially and persistently elevated.


CONCLUSIONS
Increased circulating levels of VCAM-1 and ET-1 are present during stroke.
Brondani
Rosane
R
Division of Neurology, Hospital de Clínicas de Porto Alegre, Graduate Program in Clinical Medicine, Universidade Federal do Rio Grande do Sul, RS, Brazil.
Rieder
Carlos R M
CR
Valente
Denise
D
Araújo
Luis F
LF
Clausell
Nadine
N
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000150:complications*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D015415:Biomarkers; D019332:Endothelin-1; D019010:Vascular Cell Adhesion Molecule-1