title: Bioadhesive controlled release systems of ornidazole for vaginal delivery.
abstract: Our objective was to develop a bioadhesive vaginal tablet formulation of ornidazole by using different polymer mixtures, to evaluate the bioadhesive tablet properties, and to investigate the irritation potential of the formulations to the rat vaginal tissue. Vaginal tablets of ornidazole were directly compressed with bioadhesive and swellable polymer mixtures as release-controlled agents. Carbopol 934 (Cp), pectin (Pc), hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose (Na CMC), and guar gum (GG) were used in different ratios. Bioadhesive properties, swelling capacity, release studies, and histological studies of the formulations were carried out. The bioadhesive strength between bovine vagina and surface of the tablets was determined by tensile experiments, and it was found to be dependent on Cp content. The release mechanism was described and found to be non-Fickian for all formulations. Dissolution data were evaluated statistically. No histological damage was found except one formulation containing high amount of guar gum.
authors.affiliation: Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, Turkey. esra.baloglu@ege.edu.tr
authors.forename: Esra
authors.initials: E
authors.lastname: Baloğlu
authors.forename: Mine
authors.initials: M
authors.lastname: Ozyazici
authors.forename: Sinem
authors.initials: S
authors.lastname: Yaprak Hizarcioğlu
authors.forename: Taner
authors.initials: T
authors.lastname: Senyiğit
authors.forename: Doğan
authors.initials: D
authors.lastname: Ozyurt
authors.forename: Cetin
authors.initials: C
authors.lastname: Pekçetin
mesh_terms: D000268:Adhesiveness; D000282:Administration, Intravaginal; D000818:Animals; D001696:Biomechanical Phenomena; D002417:Cattle; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008962:Models, Theoretical; D009950:Ornidazole / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010599:Pharmacokinetics; D011108:Polymers / Q000493:pharmacokinetics / Q000627:therapeutic use; D051381:Rats; D012995:Solubility; D013607:Tablets; D017155:Wettability
chemical_list: D003692:Delayed-Action Preparations; D011108:Polymers; D013607:Tablets; D009950:Ornidazole