[A Nematode Nobel Prize: Caenorhabditis elegans].
The Nematode Caenorhabditis elegans (C. elegans) is an established model increasingly used for studying human disease pathogenesis. C. elegans models are based on the mutagenesis of human disease genes conserved in this Nematode or on the transgenesis with disease genes not conserved in C. elegans. Genetic examinations will give new insights on the cellular and molecular mechanisms that are altered in some neurodegenerative diseases like Duchenne's muscular dystrophy, Huntington's disease and Alzheimer's disease. C. elegans may be used for primary screening of new compounds that may be used as drugs in these diseases.
Savel
J
J
Membre de l'Académie nationale de pharmacie, BP 68, F 75261 Paris Cedex 06.
Clostre
F
F
D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D001424:Bacterial Infections / Q000503:physiopathology; D017173:Caenorhabditis elegans / Q000235:genetics / Q000382:microbiology / Q000502:physiology*; D004195:Disease Models, Animal; D005718:Gametogenesis; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000503:physiopathology; D020388:Muscular Dystrophy, Duchenne / Q000235:genetics / Q000503:physiopathology; D009446:Neurobiology; D009613:Nobel Prize; D012098:Reproduction