title: Chemotherapy and targeted molecular therapies for brain metastases.
abstract: As therapy for systemic cancers improves, an increasing number of patients are developing brain metastases. Although conventional therapy with surgery, radiation therapy and radiosurgery has improved the outcome of a significant number of patients, many develop multiple lesions that are not amenable to standard treatments. In this review, the current role of chemotherapy and targeted molecular agents for brain metastases is summarized and future directions are discussed.
authors.affiliation: Center for Neuro-oncology Dana-Farber/Brigham and Women's Cancer Center, and Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA. jdrappatz@partners.org
authors.forename: Jan
authors.initials: J
authors.lastname: Drappatz
authors.forename: Patrick Y
authors.initials: PY
authors.lastname: Wen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary*; D016503:Drug Delivery Systems / Q000379:methods*; D018390:Gene Targeting / Q000379:methods*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents