title: Polymorphism of egfr Intron1 is associated with susceptibility and severity of asthma.
abstract: To clarify the associations of the egfr CA repeat polymorphism with asthma and its severity, we examined 579 Japanese asthmatics and 232 control subjects. The number of CA repeat ranges from 9 to 24. Asthmatic patients had a significantly higher incidence of having shorter alleles (<==16 CA repeats) compared with control subjects (p < 0.05). The most severe asthmatic patients have the highest frequency of short alleles (p < 0.05). In addition, subjects treated with leukotriene modifiers had higher incidence of having shorter allele compared to those without it (p < 0.01). Thus, the egfr CA repeat polymorphism is associated with the susceptibility and the severity of asthma.
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima City, Japan.
authors.forename: Xintao
authors.initials: X
authors.lastname: Wang
authors.forename: Junpei
authors.initials: J
authors.lastname: Saito
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Munakata
mesh_terms: D000328:Adult; D000483:Alleles; D001249:Asthma / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D018900:Dinucleotide Repeats; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D066246:ErbB Receptors