title: Doppler flow velocimetry in the superior mesenteric artery on the first day of life in preterm infants and the risk of neonatal necrotizing enterocolitis.
abstract: OBJECTIVE
  The purpose of this work was to relate Doppler indices of splanchnic perfusion and vascular resistance to the risk of developing necrotizing enterocolitis.
  
  
  METHODS
  We conducted a prospective cohort study with analysis of Doppler flow velocity waveforms of splanchnic vessels on the first day of life. Clinical management and diagnosis of necrotizing enterocolitis were performed blind to the Doppler results in a tertiary NICU on 64 eligible preterm neonates admitted for intensive care. We measured necrotizing enterocolitis using an objective diagnostic classification.
  
  
  RESULTS
  When adjusted for gestational age at birth, the following indices of the Doppler flow velocity wave form in the superior mesenteric artery were significantly predictive of the risk of necrotizing enterocolitis: end-diastolic velocity, mean velocity, and pulsatility index. The association between necrotizing enterocolitis and Doppler velocimetry indicative of high vascular resistance was independent of a range of other factors and comorbidities (race, mode of delivery, umbilical arterial catheter, growth restriction, patent ductus arteriosus, jaundice, respiratory distress syndrome, mechanical ventilation, and hypotension).
  
  
  CONCLUSIONS
  We concluded that neonates with high resistance patterns of blood flow velocity in the superior mesenteric artery on the first day of life are at increased risk of developing necrotizing enterocolitis.
authors.affiliation: Neonatal Intensive Care Unit, Addenbrooke's Hospital, Cambridge, United Kingdom. edile.murdoch@addenbrookes.nhs.uk
authors.forename: Edile M
authors.initials: EM
authors.lastname: Murdoch
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Sinha
authors.forename: Shanti T
authors.initials: ST
authors.lastname: Shanmugalingam
authors.forename: Gordon C S
authors.initials: GC
authors.lastname: Smith
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Kempley
mesh_terms: D020345:Enterocolitis, Necrotizing; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D017078:Laser-Doppler Flowmetry; D017538:Mesenteric Artery, Superior; D011446:Prospective Studies; D012307:Risk Factors