Liquid chromatographic enantiomer resolution of N-hydrazide derivatives of 2-aryloxypropionic acids on a crown ether derived chiral stationary phase.
The liquid chromatographic separation of the enantiomers of several N-hydrazide derivatives of 2-aryloxypropionic acids was performed on a crown ether type chiral stationary phase derived from (18-crown-6)-2,3,11,12-tetracarboxylic acid. The behavior of chromatographic parameters by the change of mobile phases and additives for the resolution of these analytes was investigated. The enantiomers of all analytes were base-line resolved with a mobile phase of 100% methanol containing 20 mM H2SO4. These results are the first reported for enantiomer resolution of chiral acids of 2-aryloxypropionic acids as their N-hydrazide derivatives.
Jin
Jing Yu
JY
College of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea.
Lee
Wonjae
W
D002853:Chromatography, Liquid; D043844:Crown Ethers; D011422:Propionates / Q000302:isolation & purification*; D013237:Stereoisomerism
D043844:Crown Ethers; D011422:Propionates