[A search for amyloidogenic regions in protein chain].
We suggest a new method to detect amyloidogenic regions in a protein sequence. In the present work it is shown that regions enriched with amino acid residues which have a high expected packing density are responsible for the amyloid formation. Our predictions are consistent with known disease-related amyloidogenic regions for 8 of 11 amyloid-forming proteins and peptides in which positions of amyloidogenic regions have been revealed experimentally.
Galzitskaia
O V
OV
Garbuzinskiĭ
S A
SA
Lobanov
M Iu
MIu
D000682:Amyloid / Q000737:chemistry*; D030562:Databases, Protein; D008956:Models, Chemical; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
D000682:Amyloid; D011506:Proteins