Wnt/beta-catenin signaling in development and disease.
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
Clevers
Hans
H
Hubrecht Laboratory and Utrecht University, Uppsalalaan 8, 3584CT, Utrecht, the Netherlands. clevers@niob.knaw.nl
D000328:Adult; D000818:Animals; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D018095:Germ-Line Mutation; D006801:Humans; D007414:Intestinal Neoplasms / Q000209:etiology; D015398:Signal Transduction; D015534:Trans-Activators / Q000502:physiology*; D051153:Wnt Proteins; D051176:beta Catenin
D015534:Trans-Activators; D051153:Wnt Proteins; D051176:beta Catenin