Sporminarins A and B: antifungal metabolites from a fungicolous isolate of Sporormiella minimoides.
Cultures of a fungicolous isolate of Sporormiella minimoides afforded two new polyketide metabolites which we have named sporminarins A (1) and B (2). The planar structures of 1 and 2 were elucidated by analysis of NMR and MS data, and by chemical methods. 1 exhibited significant antifungal activity against Aspergillus flavus.
Mudur
Sanjay V
SV
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Gloer
James B
JB
Wicklow
Donald T
DT
D000475:Alkenes / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota; D001231:Aspergillus flavus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D011714:Pyrans / Q000494:pharmacology
D000475:Alkenes; D000935:Antifungal Agents; D011714:Pyrans; C515295:sporminarin A; C515294:sporminarin B