title: Fluoxetine monotherapy in attention-deficit/hyperactivity disorder and comorbid non-bipolar mood disorders in children and adolescents.
abstract: Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing comorbid non-bipolar mood disorders. Fluoxetine monotherapy is an established treatment for pediatric mood disorders; however its efficacy in ADHD and comorbid mood disorder is unknown. Therefore, we evaluated 30 children who met DSM-IV criteria for ADHD and comorbid non-bipolar mood disorders in a prospective, 6-12-week open-label, study of fluoxetine monotherapy. Fluoxetine was associated with significant decreases in the severity of depressive symptoms, and also, associated with significant decreases on subscales of inattention/overactivity and aggression/defiant symptoms-47% of participants were much or very much improved without observed adverse effects.
authors.affiliation: Department of Psychiatry, Louisiana State University Health Sciences Center School of Medicine at New Orleans, 1542 Tulane Avenue, New Orleans, LA 70112, USA. hquint@lsuhsc.edu
authors.forename: Humberto
authors.initials: H
authors.lastname: Quintana
authors.forename: Grant J
authors.initials: GJ
authors.lastname: Butterbaugh
authors.forename: William
authors.initials: W
authors.lastname: Purnell
authors.forename: Ann K
authors.initials: AK
authors.lastname: Layman
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000453:epidemiology*; D002648:Child; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology*; D011446:Prospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors