title: Signal-to-noise ratio and spectral linewidth improvements between 1.5 and 7 Tesla in proton echo-planar spectroscopic imaging.
abstract: This study characterizes gains in sensitivity and spectral resolution of proton echo-planar spectroscopic imaging (PEPSI) with increasing magnetic field strength (B(0)). Signal-to-noise ratio (SNR) per unit volume and unit time, and intrinsic linewidth (LW) of N-acetyl-aspartate (NAA), creatine (Cr), and choline (Cho) were measured with PEPSI at 1.5, 3, 4, and 7 Tesla on scanners that shared a similar software and hardware platform, using circularly polarized (CP) and eight-channel phased-array (PA) head coils. Data were corrected for relaxation effects and processed with a time-domain matched filter (MF) adapted to each B(0). The SNR and LW measured with PEPSI were very similar to those measured with conventional point-resolved spectroscopy (PRESS) SI. Measurements with the CP coil demonstrated a nearly linear SNR gain with respect to B(0) in central brain regions. For the PA coil, the SNR-B(0) relationship was less than linear, but there was a substantial SNR increase in comparison to the CP coil. The LW in units of ppm decreased with B(0), resulting in improved spectral resolution. These studies using PEPSI demonstrated linear gains in SNR with respect to B(0), consistent with theoretical expectations, and a decrease in ppm LW with increasing B(0).
authors.affiliation: MIND Institute, Albuquerque, New Mexico 87131, USA. otazo@ece.unm.edu
authors.forename: Ricardo
authors.initials: R
authors.lastname: Otazo
authors.forename: Bryon
authors.initials: B
authors.lastname: Mueller
authors.forename: Kamil
authors.initials: K
authors.lastname: Ugurbil
authors.forename: Lawrence
authors.initials: L
authors.lastname: Wald
authors.forename: Stefan
authors.initials: S
authors.lastname: Posse
mesh_terms: D016477:Artifacts; D001704:Biopolymers / Q000032:analysis*; D017352:Echo-Planar Imaging / Q000379:methods*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D011522:Protons; D011829:Radiation Dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D001704:Biopolymers; D011522:Protons