title: Toxicological effects of Carica papaya seed extract on spermatozoa of mice.
abstract: Investigations were carried out on epididymal spermatozoa of male mice to study the effects of high dosages (100, 200 and 300 mg kg(-1) bwt) of aqueous Carica papaya seed extract. The results revealed a significant dosedependent suppression of cauda epididymal sperm motility coinciding with a decrease in sperm count and viability. When tested 45 days after the withdrawal of treatment, complete normalcy was restored, proving that the induced effects were transient.
authors.affiliation: Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad-380009, India. ramtejverma2000@yahoo.com
authors.forename: R J
authors.initials: RJ
authors.lastname: Verma
authors.forename: Deepa
authors.initials: D
authors.lastname: Nambiar
authors.forename: N J
authors.initials: NJ
authors.lastname: Chinoy
mesh_terms: D000818:Animals; D029441:Carica; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000633:toxicity*; D012639:Seeds; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D010936:Plant Extracts