title: Vaccine manufacturing: challenges and solutions.
abstract: The recent influenza vaccine shortages have provided a timely reminder of the tenuous nature of the world's vaccine supply and the potential for manufacturing issues to severely disrupt vital access to important vaccines. The application of new technologies to the discovery, assessment, development and production of vaccines has the potential to prevent such occurrences and enable the introduction of new vaccines. Gene-based vaccines, virus-like particles, plant-derived vaccines and novel adjuvants and delivery systems represent promising approaches to creating safer, more potent vaccines. As a consequence, more people will have faster access to more effective vaccines against a broader spectrum of infectious diseases. However, the increased cost of producing new vaccines and regulatory uncertainty remain challenges for vaccine manufacturers.
authors.affiliation: Novartis Vaccines and Diagnostics, 4560 Horton St., Mailstop 4.3, Emeryville, California 94608, USA. jeffrey_ulmer@chiron.com
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Ulmer
authors.forename: Ulrich
authors.initials: U
authors.lastname: Valley
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
mesh_terms: D001709:Biotechnology / Q000639:trends; D003365:Costs and Cost Analysis; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D004345:Drug Industry / Q000191:economics / Q000379:methods* / Q000639:trends; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control*; D013678:Technology, Pharmaceutical / Q000191:economics / Q000379:methods* / Q000639:trends; D014612:Vaccines / Q000096:biosynthesis / Q000138:chemical synthesis / Q000191:economics / Q000600:supply & distribution*
chemical_list: D014612:Vaccines