title: Traceless solid-phase synthesis of substituted xanthines.
abstract: A traceless solid-phase route to substituted xanthines, based on the late-stage pyrimidine ring closure, has been developed. This method is especially useful for the preparation of xanthines containing a variety of substituents at the N1, N3, N7, and C8 positions in an unambiguous manner. A representative set of 22 compounds was prepared.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Rongjun
authors.initials: R
authors.lastname: He
authors.forename: Shi Min
authors.initials: SM
authors.lastname: Ching
authors.forename: Yulin
authors.initials: Y
authors.lastname: Lam
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism; D014970:Xanthines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D012996:Solutions; D014970:Xanthines