title: Photoinduced signal amplification through controlled externally sensitized fragmentation in masked sensitizers.
abstract: Addition of lithiated dithianes to diaryl ketones, potential electron-transfer sensitizers, disrupts conjugation between the two aromatic moieties, effectively masking the sensitizer. A novel photoamplification strategy is developed based on photosensitized cleavage in such adducts, where each fragmentation event releases more diaryl ketone, capable of sensitization. As a result, mass release of dithianes, triggered with a very small amount of the initiator, is observed. Such amplified release can be made contingent on a molecular recognition event, offering a promising methodology for high throughput bioanalytical applications. The concept is proved with the use of micro- and nanosized polymeric supports, including dendrimers.
authors.affiliation: Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208-2436, USA.
authors.forename: Rudresha
authors.initials: R
authors.lastname: Kottani
authors.forename: Janaki R R
authors.initials: JR
authors.lastname: Majjigapu
authors.forename: Alexei
authors.initials: A
authors.lastname: Kurchan
authors.forename: Kavitha
authors.initials: K
authors.lastname: Majjigapu
authors.forename: Tiffany P
authors.initials: TP
authors.lastname: Gustafson
authors.forename: Andrei G
authors.initials: AG
authors.lastname: Kutateladze
mesh_terms: D008956:Models, Chemical; D010777:Photochemistry