title: [Functional mechanism of glucocorticoid in bone turnover and bone structure].
abstract: The functional mechanism of glucocorticoid (GC)-induced osteoporosis is not fully understood. We examined to the effects of GC on bone turnover, minerals, structure, and bone strength in growing minipigs. GC administration caused prolongation of the period of bone tissue turnover in both trabecular and cortical bone and imbalance in bone formation and resorption, consequently leading to osteoporosis in growing minipigs. Bone structure were deteriorated both trabeculare and cortex. Deterioration of cortical bone rather than trabecular bone could play a role as main factor of bone fragilities in GC-induced osteoporosis.
authors.affiliation: Ken-ai Kinen Hospital, Department of Orthopedic Surgery.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Shoujiro
authors.initials: S
authors.lastname: Akahoshi
authors.forename: Akinori
authors.initials: A
authors.lastname: Sakai
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000139:chemically induced; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D002113:Calcification, Physiologic / Q000187:drug effects; D005938:Glucocorticoids / Q000009:adverse effects*; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D013552:Swine; D013556:Swine, Miniature; D013718:Tensile Strength / Q000187:drug effects
chemical_list: D005938:Glucocorticoids