title: [Haptoglobin polymorphism in patients with inflammatory bowel diseases].
abstract: BACKGROUND
  Since functional differences were found among three major haptoglobin phenotypes, haptoglobin polymorphism was reported to be associated with the risk and clinical course of different inflammatory diseases. The aim of the study was to investigate the Hp polymorphism distribution in Hungarian Crohn's disease patients.
  
  
  METHODS
  511 Hungarian IBD patients were investigated (Crohn's disease patients: 468, m/f ratio: 233/235, duration 8.2 +/- 6.7 ys, and ulcerative colitis patients: 43, m/f: 22/21, duration: 9.5 +/- 10.6 ys) and 384 healthy subjects served as controls. Hp phenotypes were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis of sera followed by immunoblotting. Clinical data were come by the questionnaires prepared by the physicians.
  
  
  RESULTS
  The frequency of haptoglobin-1 allele was significantly higher in Crohn's disease (0.395) compared to the controls (0.345; OR: 1.24, 95%CI: 1.02-1.52, p = 0.03), but the phenotype distribution showed no such differences. Haptoglobin phenotype was associated to disease behavior in Crohn's disease (B1 and B2, in haptoglobin 1-1 and 2-2: 36.6%-34.3% and 32.4%-32.5% vs. in 2-1: 44.9% and 20.3%; ORB1Hp2-1 vs. others: 2.06, 95%CI: 1.29-3.28). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in haptoglobin 2-2, compared to the 1-1 (6.5% vs. 0.0%, p = 0.039). No associations were found in ulcerative colitis.
  
  
  CONCLUSIONS
  haptoglobin-1 allele was associated with Crohn's disease, whereas the phenotypes with the disease behavior and frequency of primary sclerosing cholangitis, exhibiting a disease-modifying effect.
authors.affiliation: Debreceni Egyetem, Orvos- es Egészségtudományi Centrum, Belgyógyászati Intézet, Gasztroenterológiai Tanszék, Debrecen. drpappm@yahoo.com
authors.forename: Mária
authors.initials: M
authors.lastname: Papp
authors.forename: Péter László
authors.initials: PL
authors.lastname: Lakatos
authors.forename: Károly
authors.initials: K
authors.lastname: Palatka
authors.forename: Ildikó
authors.initials: I
authors.lastname: Földi
authors.forename: Miklós
authors.initials: M
authors.lastname: Udvardy
authors.forename: Jolán
authors.initials: J
authors.lastname: Hársfalvi
authors.forename: István
authors.initials: I
authors.lastname: Tornai
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Vitális
authors.forename: Tamás
authors.initials: T
authors.lastname: Dinya
authors.forename: Agota
authors.initials: A
authors.lastname: Kovács
authors.forename: Tamás
authors.initials: T
authors.lastname: Molnár
authors.forename: Pál
authors.initials: P
authors.lastname: Demeter
authors.forename: János
authors.initials: J
authors.lastname: Papp
authors.forename: László
authors.initials: L
authors.lastname: Lakatos
authors.forename: István
authors.initials: I
authors.lastname: Altorjay
mesh_terms: D000328:Adult; D015209:Cholangitis, Sclerosing / Q000235:genetics; D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D005260:Female; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D011795:Surveys and Questionnaires; D051197:Toll-Like Receptor 4 / Q000235:genetics
chemical_list: D006242:Haptoglobins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4