Peptides made to order.
How loading of major histocompatibility complex (MHC) class I-specific peptides by conserved degradation machinery is performed economically has now been resolved by Kanaseki et al. (2006) in this issue of Immunity: The individual MHC molecule serves as a template for its own ligand.
Rammensee
Hans-Georg
HG
Department of Immunology, University of Tübingen, D-72076 Tübingen, Germany.
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000941:Antigens / Q000276:immunology / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000276:immunology / Q000378:metabolism*
D000941:Antigens; D015395:Histocompatibility Antigens Class I; D010455:Peptides