title: A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia.
abstract: Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that forebrain morphogenesis differs significantly from prior hypotheses. We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell movements or introducing new erroneous behaviours.
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: England
authors.forename: Guy B
authors.initials: GB
authors.lastname: Blanchard
authors.forename: L
authors.initials: L
authors.lastname: Mahadevan
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Adams
mesh_terms: D000818:Animals; D005124:Eye Abnormalities / Q000196:embryology* / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D009154:Mutation; D016548:Prosencephalon / Q000196:embryology*; D051153:Wnt Proteins / Q000235:genetics; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics; D029961:Zebrafish Proteins / Q000235:genetics
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D051153:Wnt Proteins; C092568:Wnt11 protein, zebrafish; D029961:Zebrafish Proteins; C512832:ndr2 protein, zebrafish