title: Paget's disease of the bone: a report of three cases.
abstract: Paget's disease is uncommon in Asians. We present 3 patients with varying manifestations. A 50 years old lady was detected to have raised alkaline phosphatase at a routine health check-up. Isoenzyme studies confirmed its bony origin. Bone scan revealed polyostotic disease. A 65 years old male patient with known Paget's disease of 6 years duration presented with pelvic girdle pain, progressive increase in alkaline phosphatase levels and worsening bone scan. A 45 years old male was admitted with chest pain. Cardiac evaluation was normal. Bone scan picked up a cough fracture in the left 7th rib and an incidental Paget's disease of the skull. All three had elevated markers of bone metabolism in the serum and urine. With monthly intravenous pamidronate there was significant improvement in the bone markers and follow-up bone scans.
authors.affiliation: Rheumatology Division, PD Hinduja Hospital and MRC, Veer Savarkar Marg, Mumbai.
authors.forename: K
authors.initials: K
authors.lastname: Bhatt
authors.forename: C
authors.initials: C
authors.lastname: Balakrishnan
authors.forename: G
authors.initials: G
authors.lastname: Mangat
authors.forename: K
authors.initials: K
authors.lastname: Bajan
authors.forename: T
authors.initials: T
authors.lastname: Ashavaid
authors.forename: V R
authors.initials: VR
authors.lastname: Joshi
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002637:Chest Pain / Q000209:etiology; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D000077268:Pamidronate; D017699:Pelvic Pain / Q000209:etiology; D011877:Radionuclide Imaging; D013667:Technetium
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D013667:Technetium; D000469:Alkaline Phosphatase; D000077268:Pamidronate