title: MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study.
abstract: The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients had progressed to dementia (9 to Alzheimer's disease (AD)). In Cox regression analysis the baseline volumes of the right hippocampus, the right entorhinal cortex and CDR sum of boxes predicted the progression of MCI to dementia during the follow-up. In a bivariate analysis, only the baseline volumes of entorhinal cortex predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD.
authors.affiliation: Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland. tero.tapiola@uku.fi
authors.forename: Tero
authors.initials: T
authors.lastname: Tapiola
authors.forename: Corina
authors.initials: C
authors.lastname: Pennanen
authors.forename: Mia
authors.initials: M
authors.lastname: Tapiola
authors.forename: Susanna
authors.initials: S
authors.lastname: Tervo
authors.forename: Miia
authors.initials: M
authors.lastname: Kivipelto
authors.forename: Tuomo
authors.initials: T
authors.lastname: Hänninen
authors.forename: Maija
authors.initials: M
authors.lastname: Pihlajamäki
authors.forename: Mikko P
authors.initials: MP
authors.lastname: Laakso
authors.forename: Merja
authors.initials: M
authors.lastname: Hallikainen
authors.forename: Anne
authors.initials: A
authors.lastname: Hämäläinen
authors.forename: Matti
authors.initials: M
authors.lastname: Vanhanen
authors.forename: Eeva-Liisa
authors.initials: EL
authors.lastname: Helkala
authors.forename: Ritva
authors.initials: R
authors.lastname: Vanninen
authors.forename: Aulikki
authors.initials: A
authors.lastname: Nissinen
authors.forename: Roberta
authors.initials: R
authors.lastname: Rossi
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Frisoni
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics; D003072:Cognition Disorders / Q000235:genetics / Q000473:pathology*; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models
chemical_list: D001057:Apolipoproteins E