Organocatalytic regioselective Michael additions of cyclic enones via asymmetric phase transfer catalysis.
Cyclohexanone and cycloheptanone can be enantioselectively functionalized in the 3-position with up to 92% ee and 87% ee, respectively, by the base-promoted dimerization of the corresponding enones using 3,4,5-tribenzyloxybenzyl cinchoninium bromide, as a new effective catalyst.
Ceccarelli
Roberto
R
Dipartimento di Chimica and Istituto di Chimica Biomolecolare del CNR-Sezione di Roma, Università La Sapienza, P le Aldo Moro 5, 00185-Roma, Italy.
Insogna
Susanna
S
Bella
Marco
M