[Herpes simplex virus vaccines: perspectives].
OBJECTIVE
Despite effective antiviral therapy, infection with herpes simplex virus (HSV) is a critical public health issue, particularly genital herpes by its social and psychological burden and its contribution to the neonatal herpes and possibly to the HIV/AIDS pandemic.


BACKGROUND
Many prophylactic and therapeutic vaccination approaches have been explored but no effective vaccine is presently available. In fact, as members of the Herpesviridae family, both HSV-1 and 2 types have genes involved in immune evasion.


CONCLUSIONS
Further research is needed to define determinants of immunity in order to design more effective vaccines.
Deback
C
C
Service de virologie du groupe hospitalier de la Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. claire.deback@psl.aphp.fr
Huraux
J-M
JM
D017326:Clinical Trials, Phase III as Topic; D006561:Herpes Simplex / Q000276:immunology / Q000517:prevention & control*; D022301:Herpes Simplex Virus Vaccines; D006801:Humans; D018139:Simplexvirus / Q000276:immunology
D022301:Herpes Simplex Virus Vaccines