A study of physiologic angiogenesis in the human using the dental pulp as an in vivo model.
With the commonly used in vivo animal models of angiogenesis, direct extrapolation of results to the human is not possible. The results presented from this study exemplify various phases of angiogenesis, from cell migration to apoptosis. This supports the use of the dental pulp of the developing human tooth as a viable model of in vivo physiologic angiogenesis.
Arfuso
Frank
F
School of Dentistry, Oral Health Centre of Western Australia, The University of Western Australia, Nedlands, Australia. farfuso@ohcwa.uwa.edu.au
D017209:Apoptosis; D002465:Cell Movement; D003782:Dental Pulp / Q000098:blood supply* / Q000166:cytology; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D020286:Pericytes / Q000166:cytology / Q000502:physiology; D014070:Tooth