title: Determination of n-octanol-water partition coefficients by hollow-fiber membrane solvent microextraction coupled with HPLC.
abstract: A novel direct method has been developed for determination of n-octanol-water partition coefficients by hollow-fiber membrane solvent microextraction (HFMSME) combined with high-performance liquid chromatography (HPLC). The compound of interest is dissolved in water with sonication and a hollow fiber containing octanol inside is placed in the sample solution to perform microextraction. After microextraction the concentrations in both the aqueous and n-octanol phases are analyzed by HPLC with UV detection. The method was evaluated with ten reference compounds and shown to be suitable for determination of the partition coefficients of organic compounds accurately, cheaply, simply, and quickly. Previously unknown n-octanol-water partition coefficients have been obtained for other compounds by use of the hollow-fiber membrane solvent-microextraction technique.
authors.affiliation: College of Pharmaceutical Sciences and Biotechnology, Tianjin University, Tianjin 300072, People's Republic of China. york_guo@yahoo.com
authors.forename: Yu Gao
authors.initials: YG
authors.lastname: Guo
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Dan Ning
authors.initials: DN
authors.lastname: Liu
authors.forename: Hua Feng
authors.initials: HF
authors.lastname: Fu
mesh_terms: D020003:1-Octanol / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D012997:Solvents; D014867:Water / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D012997:Solvents; D014867:Water; D020003:1-Octanol; C023650:aniline