title: [Chronic effects of transmyocardial laser revascularization combined with off-pump coronary artery by pass (OPCAB) compared with OPCAB alone in patients with ischemic heart disease: a prospective multicenter follow-up study].
abstract: OBJECTIVE
  To approach the long term safety and efficacy of transmyocardial laser revascularization (TMLR, holmium: YAG) combined with off-pump coronary artery bypass (OPCAB) compared with OPCAB alone in patients with ischemic cardiac disease.
  
  
  METHODS
  Between 1999 and 2005, 80 patients with diffusely diseased target vessels from two centers in Beijing were enrolled to the study and randomized to receive either TMLR/OPCAB (n = 40) or OPCAB (n = 40) operation. Baseline demographics and operative characteristics were similar between groups. Follow-up (mean 3.4 +/- 1.7 years) included CCS angina class and NYHA classification assessments, 6 minutes walking test (6MWT) and echocardiography.
  
  
  RESULTS
  Perioperative mortality was 5% in both groups. No death occurred during follow up. At the end of follow-up, patients at both groups experienced significant improvement on angina score compared with baseline, and angina score was also significantly lower (1.21 +/- 0.42 vs. 1.57 +/- 0.87, P = 0.03) and 6MWT-distance significantly increased (518.0 +/- 65.5 m vs. 473.8 +/- 65.8m, P = 0.006) in OPCAB/TMLR group than that in the OPCAB group. Fewer patients developed recurrent severe angina and received re-CABG/PCI in OPCAB/TMLR group than that in the OPCAB (1 vs. 6 cases, P = 0.113). NYHA and LVEF were similar between the groups at the end of follow up.
  
  
  CONCLUSIONS
  Our study showed that the addition of TMLR to OPCAB is superior in improving angina and exercise tolerance, but there is no further improvement in cardiac function compared to OPCAB alone.
authors.affiliation: Department of Cardiovascular Surgery, People's Hospital, Peking University, Beijing 100044, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Wan
authors.forename: Jing-xuan
authors.initials: JX
authors.lastname: Guo
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Ji-yan
authors.initials: JY
authors.lastname: Xie
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000368:Aged; D016342:Angioplasty, Laser; D003131:Combined Modality Therapy; D047549:Coronary Artery Bypass, Off-Pump; D003327:Coronary Disease / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D011446:Prospective Studies; D012189:Retrospective Studies