title: Site specific changes of redox metabolism in adipose tissue of obese Zucker rats.
abstract: Adipose tissues are differently involved in lipid metabolism and obesity according to their type and location. Increasing reports stress on the impact of redox metabolism on obesity and metabolic syndrome. The aim of this work is to investigate the site-specific redox metabolism in three different adipose tissues and its changes occurring in obesity. We analysed enzymatic and non-enzymatic parameters, and focused on the reduced/oxidized glutathione and coenzyme Q couples. In lean compared with obese non-diabetic Zucker rats, interscapular brown fat seems well protected against oxidative stress and epididymal adipose tissue shows a more reduced glutathione redox state, associated with a higher susceptibility to lipophilic oxidative stress than inguinal adipose tissue. Epididymal adipose tissue redox metabolism significantly differs from inguinal one by its limited redox metabolism adaptation. Our results demonstrate site-specific managements of reactive oxygen species metabolism in obese Zucker rats. These results are not consistent with the classic deciphering of inflammatory situation and produce a new conception of the redox parameters implication in the development of the metabolic syndrome.
authors.affiliation: IFR 31, UMR 5018 CNRS-UPS, Bât L1, CHU Rangueil, TSA 50032, 31059 Toulouse Cedex 9, France. galinier.a@chu-toulouse.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Galinier
authors.forename: Audrey
authors.initials: A
authors.lastname: Carriere
authors.forename: Yvette
authors.initials: Y
authors.lastname: Fernandez
authors.forename: Sylvie
authors.initials: S
authors.lastname: Caspar-Bauguil
authors.forename: Brigitte
authors.initials: B
authors.lastname: Periquet
authors.forename: Alain
authors.initials: A
authors.lastname: Periquet
authors.forename: Luc
authors.initials: L
authors.lastname: Penicaud
authors.forename: Louis
authors.initials: L
authors.lastname: Casteilla
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004822:Epididymis / Q000378:metabolism / Q000473:pathology; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D011924:Rats, Zucker; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014451:Ubiquinone / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D014451:Ubiquinone; D005978:Glutathione