title: Rectal adenocarcinoma following cranio-spinal radiotherapy for cerebellar medulloblastoma.
abstract: The authors present a case of a 16-year-old female diagnosed with rectal adenocarcinoma 10 years after receiving cranio-spinal radiotherapy for a cerebellar medulloblastoma. While the risk of a second malignancy is recognised to be increased in children previously treated with radiotherapy, rectal adenocarcinoma is a rare presentation. A child presenting with symptoms of weight loss and a change in bowel habit in a patient who has previously received radiotherapy should alert practitioners to the possibility of a colorectal malignancy.
authors.affiliation: Paediatric Surgery, University of Oxford and John Radcliffe Hospital, Headley Way, Oxford, Oxfordshire, OX3 9DU, UK.
authors.forename: R E
authors.initials: RE
authors.lastname: Brugha
authors.forename: W
authors.initials: W
authors.lastname: Sherwood
authors.forename: A
authors.initials: A
authors.lastname: Scarsbrook
authors.forename: C
authors.initials: C
authors.lastname: Mitchell
authors.forename: K
authors.initials: K
authors.lastname: Lakhoo
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D000293:Adolescent; D002528:Cerebellar Neoplasms / Q000532:radiotherapy; D016371:Cranial Irradiation / Q000009:adverse effects; D005260:Female; D006801:Humans; D008527:Medulloblastoma / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects*; D012004:Rectal Neoplasms / Q000209:etiology*