Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder.
An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution inflammatory syndrome. Treatment with corticosteroids and transient suppression of HAART led to marked neurologic improvement.
Martinez
J V
JV
Infectious Diseases Department, Hospital Británico, Buenos Aires, Argentina.
Mazziotti
J V
JV
Efron
E D
ED
Bonardo
P
P
Jordan
R
R
Sevlever
G
G
Martinez
M
M
Verbanaz
S C
SC
Salazar
Z Salazar
ZS
Pardal
M Fernandez
MF
Reisin
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001037:Aphasia / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology; D001921:Brain / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects / Q000276:immunology; D003907:Dexamethasone / Q000627:therapeutic use; D004660:Encephalitis / Q000139:chemically induced* / Q000276:immunology* / Q000503:physiopathology; D006429:Hemiplegia / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D002479:Inclusion Bodies / Q000276:immunology / Q000473:pathology / Q000821:virology; D007577:JC Virus / Q000276:immunology / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D009836:Oligodendroglia / Q000276:immunology / Q000473:pathology / Q000821:virology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D016896:Treatment Outcome; D028761:Withholding Treatment
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone