Copper-free synthesis of skipped diynes via cross-coupling reactions of alkynylalanes with propargylic electrophiles.
Alkynylalanes provide a new, copper-free route to skipped diynes when combined with propargylic electrophiles bearing an aluminum-complexing leaving group. The reaction is mild, efficient, and, in contrast to copper-mediated methods, highly regioselective. [reaction: see text]
Kessabi
Jilali
J
SYNGENTA Crop Protection AG, Research Chemistry, CH-4002 Basel, Switzerland.
Beaudegnies
Renaud
R
Jung
Pierre M J
PM
Martin
Benjamin
B
Montel
Florian
F
Wendeborn
Sebastian
S