Use of cisplatin-containing biodegradable beads for treatment of cutaneous neoplasia in equidae: 59 cases (2000-2004).
OBJECTIVE
To determine outcome for equids with cutaneous neoplasms treated with cisplatin-containing biodegradable beads, alone or in conjunction with debulking.


METHODS
Retrospective case series.


METHODS
56 horses, 1 zebra, 1 donkey, and 1 mule.


METHODS
Medical records were reviewed. Follow-up information was obtained through telephone conversations with owners and trainers of the animals.


RESULTS
22 tumors were sarcoids, 6 were fibrosarcomas, 1 was a fibroma, 2 were peripheral nerve sheath tumors, 11 were squamous cell carcinomas, 14 were melanomas (13 gray horses and 1 bay horse), 1 was a lymphosarcoma, 1 was an adenocarcinoma, and 1 was a basal cell tumor. Forty-five (76%) animals underwent conventional or laser debulking of the tumor prior to bead implantation. Forty of 48 (83%) animals for which long-term follow-up information was available were relapse free 2 years after treatment. This included 20 of 22 animals with spindle cell tumors (including 11/13 horses with sarcoids), 6 of 10 animals with squamous cell carcinomas, 13 of 14 animals with melanomas, and 2 of 3 animals with other tumor types. Adverse effects were minimal.


CONCLUSIONS
Results suggest that implantation of cisplatin-containing biodegradable beads, with or without tumor debulking, may be an effective treatment for equidae with various cutaneous neoplasms.
Hewes
Christina A
CA
Marion DuPont Scott Equine Medical Center, Virginia-Maryland Regional College of Veterinary Medicine, Leesburg, VA 20177, USA.
Sullins
Kenneth E
KE
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary; D002945:Cisplatin / Q000627:therapeutic use*; D018397:Equidae; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy* / Q000601:surgery; D006736:Horses; D053685:Laser Therapy / Q000379:methods / Q000662:veterinary; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary; D012189:Retrospective Studies; D012509:Sarcoma / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary; D012878:Skin Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D002945:Cisplatin