title: Development of a stereoselective co-mediated dihydropyran ring contraction.
abstract: A highly stereoselective approach for the synthesis of trans-1,2-disubstituted cyclobutanes through an Al-promoted cobalt-mediated O-->C ring contraction of dihydropyrans is described. [reaction: see text].
authors.affiliation: Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Meek
authors.forename: Fabienne
authors.initials: F
authors.lastname: Pradaux
authors.forename: Emmanuel H
authors.initials: EH
authors.lastname: Demont
authors.forename: Joseph P A
authors.initials: JP
authors.lastname: Harrity
mesh_terms: D000535:Aluminum / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D003503:Cyclobutanes / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011714:Pyrans / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D003503:Cyclobutanes; D007202:Indicators and Reagents; D011714:Pyrans; D003035:Cobalt; D000535:Aluminum