title: Quantitative structure-activity relationships for toxicity of nonpolar narcotic chemicals to Pseudokirchneriella subcapitata.
abstract: This study presents data for 27 nonpolar narcotic compounds regarding toxicity to Pseudokirchneriella subcapitata as evaluated using a closed-system algal toxicity test with an exposure time of 48 h. Two test endpoints, dissolved oxygen production and algal growth rate, were used to assess the toxicity of nonpolar narcotic chemicals on algae. Hydrophobicity (1-octanol-water partition coefficient [K(OW)]) provided satisfactory descriptions for the toxicity of nonpolar narcotic compounds, and quantitative structure-activity relationships based on log K(OW) were established. The relative sensitivity of various aquatic organisms to nonpolar chemicals was as follows: P. subcapitata > Vibriofischeri > or = Nitrosomonas sp. > fathead minnow > Daphnia magna > polytox > activated sludge. In addition, linear relationships were found between the toxicity observed in P. subcapitata and other aquatic organisms, except in the case of Nitrosomonas sp. Therefore, for nonpolar toxicants, the closed-system technique applied in the present study can be an ideal surrogate for other tests, such as fathead minnow and D. magna, that are either time-consuming or labor-intensive. However, because the current toxicity database is based primarily on the conventional batch tests, it cannot provide adequate assessment regarding the effects of various organic toxicants. Therefore, more extensive research is needed to revise the database for the toxicity of organic compounds on phytoplankton using the closed-system technique.
authors.affiliation: Institute of Environmental Engineering, National Chiao Tung University, 75 Po-Ai Street, Hsinchu 300, Taiwan.
authors.forename: Shih-Hung
authors.initials: SH
authors.lastname: Hsieh
authors.forename: Chih-Hsiung
authors.initials: CH
authors.lastname: Hsu
authors.forename: Din-Yu
authors.initials: DY
authors.lastname: Tsai
authors.forename: Chung-Yuan
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000438:Alcohols / Q000633:toxicity*; D000460:Chlorophyta / Q000187:drug effects* / Q000254:growth & development; D006838:Hydrocarbons / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity*; D010100:Oxygen / Q000032:analysis; D021281:Quantitative Structure-Activity Relationship; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000438:Alcohols; D006838:Hydrocarbons; D007659:Ketones; D014874:Water Pollutants, Chemical; D010100:Oxygen