[Progress in the study of KRAB zinc finger protein].
The zinc finger proteins containing the Kruppel-associated box domain (KRAB) constitute the largest single family of transcriptional regulators in mammals. Many genes encoding members of this family are arranged in clusters. KRAB-containing proteins are characterized by the presence of 4 and over 30 C2H2 zinc-finger motifs and a KRAB domain near the amino terminus of the protein. KRAB domain behaving as a protein-protein interaction domain could bind to corepressor proteins and/or transcription factors, and that the KRAB-containing proteins could act as a repressor or corepressor and play a key role in transcriptional repression. Members of the family are involved in embryonic development, cell differentiation, cell proliferation, apoptosis, neoplastic transformation and cell cycle regulation.
Tian
Chun-Yan
CY
Laboratory of Systems Biology, Institute of Radiation Medicine, Beijing 100850, China.
Zhang
Ling-Qiang
LQ
He
Fu-Chu
FC
D000595:Amino Acid Sequence; D000818:Animals; D002468:Cell Physiological Phenomena; D002877:Chromosomes, Human / Q000378:metabolism; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D016335:Zinc Fingers
D051741:Kruppel-Like Transcription Factors