Methodology of the thyroid gland disease decision-making using profiling in steroid hormone pathway.
To find out the genetic factors of outbreak of thyroid gland disease, we developed the thyroid gland decision-making system, which processes the metabolic profile in steroid hormone map using a statistical method. Metabolic profile is a measured data of lots of mixed materials that includes not only known metabolites, but also unknown ones, which is estimated to have an influence on the thyroid gland disease. Therefore, to develop thyroid gland disease decision-making system, analyzing metabolic profile containing multi-materials would be useful for diagnosing thyroid gland disease. Because experimental values used for system construction are area values for the retention time, the observations are preprocessed through variable transition and t-test to use the area values concurrently and the highly correlated materials are estimated by principal component analysis. The thyroid gland decision-making system developed through the logistic regression is an excellent system demonstrating 98.7% accuracy in the classification table.
Kim
Young Sun
YS
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Republic of Korea.
Yoon
Chang No
CN
D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D003657:Decision Making; D004196:Disease Outbreaks; D006801:Humans; D016015:Logistic Models; D013058:Mass Spectrometry; D015233:Models, Statistical; D025341:Principal Component Analysis; D015203:Reproducibility of Results; D012307:Risk Factors; D013256:Steroids / Q000378:metabolism*; D013959:Thyroid Diseases / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism
D013256:Steroids