Podocarpaside, a triterpenoid possessing a new backbone from Actaea podocarpa.
Podocarpaside (1), a novel arabinoside possessing a unique triterpene skeleton was isolated from Actaea podocarpa, a closely related species to black cohosh (dietary supplement used for menopausal disorders). Podocarpaside belongs to a new class of triterpenoids, for which the name "ranunculane" is proposed. Compound 1 possesses anticomplement activity. [structure: see text].
Ali
Zulfiqar
Z
National Center for Natural Products Research, University of Mississippi, Mississippi 38677, USA.
Khan
Shabana I
SI
Ferreira
Daneel
D
Khan
Ikhlas A
IA
D031842:Actaea / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D051056:Complement Inactivating Agents / Q000494:pharmacology; D018360:Crystallography, X-Ray; D018922:HL-60 Cells; D006801:Humans; D018374:LLC-PK1 Cells; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D013552:Swine; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry; D014709:Vero Cells
D000970:Antineoplastic Agents; D051056:Complement Inactivating Agents; D014315:Triterpenes; C522750:podocarpaside