Cell instructive polymers.
Polymeric materials used in tissue engineering were initially used solely as delivery vehicles for transplanting cells. However, these materials are currently designed to actively regulate the resultant tissue structure and function. This control is achieved through spatial and temporal regulation of various cues (e.g., adhesion ligands, growth factors) provided to interacting cells from the material. These polymeric materials that control cell function and tissue formation are termed cell instructive polymers, and recent trends in their design are outlined in this chapter.
Matsumoto
Takuya
T
Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. tmatsu@deas.harvard.edu
Mooney
David J
DJ
D000818:Animals; D002468:Cell Physiological Phenomena / Q000187:drug effects*; D048091:Guided Tissue Regeneration; D006801:Humans; D011108:Polymers / Q000494:pharmacology*; D023822:Tissue Engineering
D011108:Polymers