title: 103Pd radioactive stent inhibits biliary duct restenosis and reduces smooth muscle actin expression during duct healing in dogs.
abstract: BACKGROUND
  This study was designed to assess the expression of smooth muscle actin (SMA) in the healing process after implanting a (103)Pd radioactive stent in the biliary duct, and to discuss the function and significance of this stent in preventing biliary stricture formation.
  
  
  METHODS
  A model of biliary injury in dogs was made and then a (103)Pd radioactive stent was positioned in the biliary duct. The expression and distribution of SMA were assessed in the anastomotic tissue 30 days after implantation of the stent.
  
  
  RESULTS
  SMA expression was less in the (103)Pd stent group than in the ordinary stent group. The (103)Pd stent inhibited scar contracture and anastomotic stenosis.
  
  
  CONCLUSIONS
  The (103)Pd stent can reduce the expression of SMA in the healing process and inhibit scar contracture and anastomotic stenosis in the dog biliary duct.
authors.affiliation: Department of General Surgery, Second Affiliated Hospital, China Medical University, Shenyang 110004, China. 23318199@163.com
authors.forename: Gui-Jin
authors.initials: GJ
authors.lastname: He
authors.forename: Qin-Yi
authors.initials: QY
authors.lastname: Gao
authors.forename: Shu-He
authors.initials: SH
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Xian-Wei
authors.initials: XW
authors.lastname: Dai
authors.forename: Kai
authors.initials: K
authors.lastname: Ma
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D017734:Bile Ducts, Extrahepatic / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D003251:Constriction, Pathologic / Q000473:pathology / Q000517:prevention & control; D004285:Dogs; D008297:Male; D009130:Muscle, Smooth / Q000378:metabolism; D010165:Palladium; D011868:Radioisotopes; D015607:Stents
chemical_list: D000199:Actins; D011868:Radioisotopes; D010165:Palladium