title: [On three revolutions of vaccine].
abstract: Since the Chinese inuented the uaniolation with human pox vaccine and Jenner invented the vaccine for cowpox, the great achievements of vaccination in preventing and treating many diseases are universally acknowledged. In 1995, the New York Academy of Sciences of America sponsored a symposium on DNA (deoxyribonucleic acid) vaccine, which is called the third revolution of vaccine and new epoch for vaccinology. The first revolution was the invention of inactivated vaccines and live attenuated vaccines represented by Pasteur at the end of the nineteenth century. The second one was the subunit of vaccine prepared by DNA recombination technique and techniques of protein chemistry in 1980s.
authors.affiliation: School of Basic Medical Science, Beijing University, Beijing 100083, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Kou
mesh_terms: D049672:History, 19th Century; D049673:History, 20th Century; D014613:Vaccines, Attenuated / Q000266:history*; D019444:Vaccines, DNA / Q000266:history*; D015164:Vaccines, Inactivated / Q000266:history*
chemical_list: D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D015164:Vaccines, Inactivated