BACing up the interferon-gamma locus.
In this issue of Immunity, Hatton et al. (2006) identify evolutionarily conserved noncoding sequences (CNSs) upstream of the interferon-gamma gene, then show by using a BAC transgene reporter that CNS-22 is a key regulator of interferon-gamma expression.
Wilson
Christopher B
CB
Department of Immunology and University of Washington, Seattle, WA 98195, USA.
Schoenborn
Jamie
J
D000818:Animals; D001483:Base Sequence / Q000235:genetics; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics*; D017124:Conserved Sequence / Q000235:genetics; D017930:Genes, Reporter; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic; D018417:Th1 Cells / Q000276:immunology*; D019076:Transgenes
D007371:Interferon-gamma