title: Diagnostic accuracy of cardiac markers for myocardial damage after radiofrequency catheter ablation.
abstract: OBJECTIVE
  This study compares serum markers of myocardial damage incurred during radiofrequency catheter ablation (RFCA).
  
  
  RESULTS
  Blood was sampled from 34 patients with atrial flutter (n = 16), atrioventricular nodal reentrant tachycardia (AVNRT; n = 13), and Wolff-Parkinson-White syndrome (WPW; n = 5) to measure creatine kinase MB subfraction (CK-MB), human heart-type fatty acid protein (h-FABP), and cardiac troponin T (cTnT) values at baseline and after RFCA. The controls comprised 12 patients without significant elevation of all myocardial markers during electrophysiological study (EPS) without RFCA. h-FABP values did not elevate significantly, whereas CK-MB and cTnT demonstrated significant change after RFCA (P < 0.001). Neither peak h-FABP nor CK-MB correlated with following RFCA parameters: delivery duration, number of RFCA discharges, and cumulative RFCA energy. In contrast, correlations were significant between mean peak values of cTnT and these RFCA parameters (all P < 0.05). The sensitivity (71.6%) and specificity (35.6%) of h-FABP were inferior to those of cTnT (93.3% and 89.8%, respectively).
  
  
  CONCLUSIONS
  h-FABP is an insensitive and less specific marker of myocardial damage in RFCA much along the lines of CK-MB and when compared with the proven accuracy of cTnT.
authors.affiliation: Department of Cardiovascular Medicine, Gifu Prefectural Government TAJIMI Hospital, Tajimi, Gifu 5078522, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Hirose
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Osamu
authors.initials: O
authors.lastname: Suzuki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Oguri
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yajima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hibino
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000601:surgery*; D001282:Atrial Flutter / Q000601:surgery; D015415:Biomarkers / Q000032:analysis*; D017115:Catheter Ablation / Q000009:adverse effects*; D052279:Creatine Kinase, MB Form / Q000097:blood*; D022062:Electrophysiologic Techniques, Cardiac; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000601:surgery; D020107:Troponin T / Q000097:blood*; D014927:Wolff-Parkinson-White Syndrome / Q000601:surgery
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D020107:Troponin T; D052279:Creatine Kinase, MB Form