[The correlation of PDGF and TNF-alpha and HA and nasal mucosa healing after ESS].
OBJECTIVE
To investigate the relation of healing outcomes and three factors in nasal fluid before and after endoscopic sinus surgery (ESS), including platelet derived growth factor (PDGF), tumour necrosis factor-alpha (TNF-alpha) and hyaluronic acid (HA).


METHODS
We compared the amounts of PDGF, TNF-alpha, HA among the three stages in 22 patients operated for nasal polyposis. The concentrations of PDGF, TNF-alpha, HA were compared before and after operation between good healing and poor healing at 12th week, and gender, age, body mass, preoperative stage were also compared. Finally, we performed a multiple logistic regression model to assess whether the healing quality was associated with gender, age, body mass, preoperative stage, and concentrations of PDGF, TNF-alpha, HA before ESS.


RESULTS
(1) A significant difference in the concentrations of PDGF and HA could be demonstrated between the first and second stage, or between the first and third stage. But there was no difference in TNF-alpha among three stages. (2) The healing quality after ESS was significantly and independently correlated to the age of patient and preoperative PDGF concentrations in nasal secretions, the younger, the better healing. The lower PDGF concentration, the better healing, and vice versa.


CONCLUSIONS
During the wound healing of nasal mucosa, the levels of PDGF, TNF-alpha, HA are different at each postoperative stage. Age and PDGF concentrations preoperatively are suitable factors to predict the healing quality after ESS.
Wei
Xianfeng
X
Department of Otorhinolaryngology-Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, 300192, China. weixianfeng3@yahoo.com.cn
Zhang
Jian
J
Zhuang
Xinhai
X
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004724:Endoscopy; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism* / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D011184:Postoperative Period; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014945:Wound Healing; D055815:Young Adult
D010982:Platelet-Derived Growth Factor; D014409:Tumor Necrosis Factor-alpha; D006820:Hyaluronic Acid