Meiotic spindle: sculpted by severing.
Katanin is a conserved AAA ATPase with the ability to sever microtubules, but its biological function in animal cells has been obscure. A recent study using electron tomography has found that katanin stimulates the production of microtubules in the meiotic spindles of Caenorhabditis elegans oocytes.
Ribbeck
Katharina
K
Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. Katharina_Ribbeck@hms.harvard.edu
Mitchison
Timothy J
TJ
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D000074201:Katanin; D008540:Meiosis / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D009865:Oocytes / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; D000251:Adenosine Triphosphatases; D000074201:Katanin