title: Epstein-Barr virus associated lymphoepithelial carcinoma of the parotid gland; a clinicopathological report of three cases.
abstract: Lymphoepithelial carcinoma is a relatively uncommon malignant tumor of the salivary gland demonstrating malignant epithelial cells with dense lymphoid stroma. The authors report three cases of lymphoepithelial carcinoma associated with Epstein-Barr virus of the right parotid gland with clinically presenting as painless, gradual enlargement of the preauricular mass. The histopathologic examination of the parotid gland is characterized by malignant epithelial cells with dense lymphoid stroma. Immunohistochemical stains show positive reactivity to cytokeratin and p53 in malignant epithelial cells. In situ hybridization of the Epstein-Barr virus-encoded Ribonucleic acid shows positivity in malignant epithelial cells. Clinical and pathologic features with relevant literatures are discussed. These are the first reported cases of primary parotid lymphoepithelial carcinoma associated with Epstein-Barr virus infection in Thailand and Southeast Asia.
authors.affiliation: Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Noppadol_l@hotmail.com
authors.forename: Noppadol
authors.initials: N
authors.lastname: Larbcharoensub
authors.forename: Nattha
authors.initials: N
authors.lastname: Tubtong
authors.forename: Veeraphol
authors.initials: V
authors.lastname: Praneetvatakul
authors.forename: Atcharaporn
authors.initials: A
authors.lastname: Pongtippan
authors.forename: Juvady
authors.initials: J
authors.lastname: Leopairat
authors.forename: Vorachai
authors.initials: V
authors.lastname: Sirikulchayanonta
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000473:pathology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000473:pathology* / Q000821:virology; D013785:Thailand