title: Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein.
abstract: Plasmodium vivax remains the most widespread Plasmodium parasite species around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP7(1)) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques.
authors.affiliation: Molecular Biology Department, Fundacion Instituto de Inmunologia de Colombia, Bogota, Colombia.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Mongui
authors.forename: Oscar
authors.initials: O
authors.lastname: Perez-Leal
authors.forename: Sara C
authors.initials: SC
authors.lastname: Soto
authors.forename: Jimena
authors.initials: J
authors.lastname: Cortes
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Patarroyo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D017780:Malaria Vaccines / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010966:Plasmodium vivax / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015800:Protozoan Proteins / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D017780:Malaria Vaccines; D008565:Membrane Proteins; D015800:Protozoan Proteins; D011994:Recombinant Proteins; C439571:merozoite surface protein 7, Plasmodium