Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.
Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.
Plath
Niels
N
Molecular Neurobiology, Department of Biology-Chemistry-Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.
Ohana
Ora
O
Dammermann
Björn
B
Errington
Mick L
ML
Schmitz
Dietmar
D
Gross
Christina
C
Mao
Xiaosong
X
Engelsberg
Arne
A
Mahlke
Claudia
C
Welzl
Hans
H
Kobalz
Ursula
U
Stawrakakis
Anastasia
A
Fernandez
Esperanza
E
Waltereit
Robert
R
Bick-Sander
Anika
A
Therstappen
Eric
E
Cooke
Sam F
SF
Blanquet
Veronique
V
Wurst
Wolfgang
W
Salmen
Benedikt
B
Bösl
Michael R
MR
Lipp
Hans-Peter
HP
Grant
Seth G N
SG
Bliss
Tim V P
TV
Wolfer
David P
DP
Kuhl
Dietmar
D
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal; D015139:Blotting, Southern / Q000379:methods; D015153:Blotting, Western / Q000379:methods; D003214:Conditioning, Classical / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000172:deficiency / Q000502:physiology*; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D019706:Excitatory Postsynaptic Potentials / Q000235:genetics / Q000502:physiology; D006624:Hippocampus / Q000166:cytology; D066298:In Vitro Techniques; D007608:Kainic Acid; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000502:physiology*; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D018408:Patch-Clamp Techniques / Q000379:methods; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism; D013037:Spatial Behavior / Q000502:physiology; D013569:Synapses / Q000235:genetics / Q000502:physiology*; D013997:Time Factors
D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; C092069:activity regulated cytoskeletal-associated protein; D007608:Kainic Acid