title: Synthesis of estradiol-pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells.
abstract: The synthesis, physico-chemical properties, cellular localization and photocytotoxicity of estradiol-pheophorbide a conjugates in estrogen-dependent cancer and vascular endothelial cells are described with the aim of increasing the photodynamic activity by targeting the nucleus of both tumor and blood vessel cells.
authors.affiliation: Laboratoire des Interactions Moléculaires et Réactivités Chimiques et Photochimiques, Université Paul Sabatier, 118 Rte de Narbonne, Toulouse Cedex 9, F-31062.
authors.forename: Naram
authors.initials: N
authors.lastname: El-Akra
authors.forename: Arielle
authors.initials: A
authors.lastname: Noirot
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Faye
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Souchard
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004249:DNA Damage; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D004958:Estradiol / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010778:Photochemotherapy; D017382:Reactive Oxygen Species; D013050:Spectrometry, Fluorescence; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D017382:Reactive Oxygen Species; D002734:Chlorophyll; D004958:Estradiol; C032623:pheophorbide a