title: [A search for amyloidogenic regions in protein chain].
abstract: We suggest a new method to detect amyloidogenic regions in a protein sequence. In the present work it is shown that regions enriched with amino acid residues which have a high expected packing density are responsible for the amyloid formation. Our predictions are consistent with known disease-related amyloidogenic regions for 8 of 11 amyloid-forming proteins and peptides in which positions of amyloidogenic regions have been revealed experimentally.
authors.forename: O V
authors.initials: OV
authors.lastname: Galzitskaia
authors.forename: S A
authors.initials: SA
authors.lastname: Garbuzinskiĭ
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Lobanov
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D030562:Databases, Protein; D008956:Models, Chemical; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
chemical_list: D000682:Amyloid; D011506:Proteins