[Effects of antiviral effects of agents and prognosis of chronic hepatitis B.].
BACKGROUND
To analyze the effects of difference antiviral agents and the effects of the treatments on long-term prognosis.


METHODS
Retrospective research method was applied.


RESULTS
About 40% of the patients were treated with interferon or lamivudine. After the treatment, in lamivudine group, the negative rate of HBV DNA was the highest. In the interferon group, the sero conversion rates of HBeAg/HBeAb were 22.9%. In the antiviral treatment patients, the disease progression and the occurrence of cirrhosis and liver cancer were much lower than those of the control groups. The mortality of cirrhosis and liver cancer in the HBeAg/HBeAb sero converted group was much lower than that of the group without HBeAg/HBeAb sero conversion groups (P less than 0.05).


CONCLUSIONS
The antiviral effects of interferon and lamivudine were better than those of the other drug groups. The antiviral drugs could relieve the disease progression and reduce the mortality of cirrhosis and liver cancer.
Chen
X Y
XY
Beijing Youan Hospital, Affiliated to Capital University of Medical Sciences, Beijing 100054, China. Corresponding author: SI Chong-wen, E-mail: yyy@bjmu.edu.cn.
Yu
Y Y
YY
Ma
L N
LN
Huang
Y L
YL
Shen
C L
CL
Zhang
W J
WJ
Xu
D Z
DZ
Si
C W
CW
D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000821:virology; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D011379:Prognosis; D012189:Retrospective Studies
D000998:Antiviral Agents; D004279:DNA, Viral; D019259:Lamivudine