Protein oxidation and degradation during aging: role in skin aging and neurodegeneration.
During aging, the products of oxidative processes accumulate and might disturb cellular metabolism. Among them are oxidized proteins and protein aggregates. On the other hand, in a functioning metabolic system oxidized proteins are degraded, mainly by the proteasome. During aging, however, proteasome activity declines. Therefore, the ability to degrade oxidized proteins is attenuated. The following review summarises the accumulation of oxidized proteins and the decline of the proteasomal system during skin and brain aging including some age-related neurodegenerative processes. The role of protein aggregates will be discussed as a potential reason for the accelerated dysfunction of tissue during aging.
Widmer
Rebecca
R
Research Institute of Environmental Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Ziaja
Isabella
I
Grune
Tilman
T
D000375:Aging / Q000502:physiology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism / Q000502:physiology*; D020836:Protein Structure, Quaternary; D011506:Proteins / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000528:radiation effects; D012879:Skin Physiological Phenomena
D016229:Amyloid beta-Peptides; D011506:Proteins; D046988:Proteasome Endopeptidase Complex