title: Sexual dysfunction in the peri- and postmenopause. Status of incidence, pharmacological treatment and possible risks. A secondary publication.
abstract: The frequency of female sexual dysfunction increases with age, and the menopausal transition has a negative effect on the sexuality. Pharmacological treatment options for female sexual dysfunction during the peri- and post-menopause include hormone therapy or sildenafil. A limited number of randomized, controlled trials have been conducted and evidence suggests that systemic hormone therapy with estrogen, estrogen/progesterone, estrogen/testosterone and tibolone have a positive impact on sexual dysfunction during the peri- and postmenopause. Further, there is evidence that treatment with local estrogen relieves vaginal dryness and dyspareunia. Recent knowledge on side effects related to hormone therapy necessitates careful evaluation of the indication for hormone therapy and the duration of postmenopausal hormone therapy should be as short as possible. Long-term side effects of testosterone have not yet been fully investigated. A positive effect of sildenafil has been observed in a limited group of women; those with arousal problems but with no desire problems. The results suggest an intensified focus on new pharmaceutical products for the treatment of female sexual dysfunction in the postmenopause. For the time being the effect of testosterone therapy and tibolone on female sexual dysfunction is being investigated. Sexual dysfunction in women (Female Sexual Dysfunction, FSD) is multi-factorial and influenced by physiological, psychological, social and emotional factors. FSD is defined in four diagnostic groups: desire-, arousal-, orgasm- and pain problems. Recently, it has been suggested that the woman herself should assess the dysfunction as distressful to be diagnosed as having a sexual dysfunction [1]. There are only a limited number of well-conducted population surveys on the prevalence of FSD. Further, relatively few randomized, controlled trials of pharmacological treatment of FSD have been carried out.
authors.affiliation: Department of Urology, Aalborg Hospital, Aarhus University Hospital, Denmark. ninagregersen@dadlnet.dk
authors.forename: Nina
authors.initials: N
authors.lastname: Gregersen
authors.forename: Pernille Tine
authors.initials: PT
authors.lastname: Jensen
authors.forename: Annamaria Elena
authors.initials: AE
authors.lastname: Giraldi
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000726:Androgen Antagonists / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage / Q000097:blood / Q000502:physiology; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use; D047648:Perimenopause; D010879:Piperazines / Q000627:therapeutic use; D011687:Purines; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy* / Q000453:epidemiology; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000453:epidemiology; D000068677:Sildenafil Citrate; D013450:Sulfones; D013739:Testosterone / Q000008:administration & dosage / Q000627:therapeutic use; D014621:Vagina / Q000187:drug effects
chemical_list: D000726:Androgen Antagonists; D004967:Estrogens; D009652:Norpregnenes; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D013739:Testosterone; D004958:Estradiol; D000068677:Sildenafil Citrate; D015106:3',5'-Cyclic-GMP Phosphodiesterases; C027385:tibolone