title: Method for the solid-phase parallel synthesis of a 6-alkylamino-2-(functionalized-aminomethyl)-2H-1-benzopyran Library.
abstract: A 2000-member library of benzopyran analogues was prepared by using a solid-phase synthesis protocol. Polymer-bound 6-alkylaminobenzopyrans 7 were synthesized as part of a first generation diversification step by employing reactions of a variety of alkyl halides with the amine 6. Transformations of the resin-bound intermediates 8 formed in this manner by reactions with acid halides, sulfonyl chlorides, and isocyanates leads to introduction of the second level of diversification found in the series of 6-alkylamino-2-(functionalized-aminomethyl)-2-methyl-2H-1-benzopyran analogues 11 and 12.
authors.affiliation: Medicinal Science Division, Korea Research Institute of Chemical Technology, Yusung-gu, Daejeon 305-600, Korea.
authors.forename: Jong Yeon
authors.initials: JY
authors.lastname: Hwang
authors.forename: Hyung-Sub
authors.initials: HS
authors.lastname: Choi
authors.forename: Jin-soo
authors.initials: JS
authors.lastname: Seo
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: La
authors.forename: Sung-eun
authors.initials: SE
authors.lastname: Yoo
authors.forename: Young-Dae
authors.initials: YD
authors.lastname: Gong
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001578:Benzopyrans