title: Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays.
abstract: New highly sensitive latent bioluminescent luciferin substrates were designed and synthesized for monitoring mammalian glutathione S-transferase (GST) and Schistosoma japonicum enzyme activities.
authors.affiliation: Promega Biosciences Inc, San Luis Obispo, CA 93401, USA. wenhui.zhou@promega.com
authors.forename: Wenhui
authors.initials: W
authors.lastname: Zhou
authors.forename: John W
authors.initials: JW
authors.lastname: Shultz
authors.forename: Nancy
authors.initials: N
authors.lastname: Murphy
authors.forename: Erika M
authors.initials: EM
authors.lastname: Hawkins
authors.forename: Laurent
authors.initials: L
authors.lastname: Bernad
authors.forename: Troy
authors.initials: T
authors.lastname: Good
authors.forename: Leonard
authors.initials: L
authors.lastname: Moothart
authors.forename: Susan
authors.initials: S
authors.lastname: Frackman
authors.forename: Dieter H
authors.initials: DH
authors.lastname: Klaubert
authors.forename: Robert F
authors.initials: RF
authors.lastname: Bulleit
authors.forename: Keith V
authors.initials: KV
authors.lastname: Wood
mesh_terms: D000818:Animals; D049454:Firefly Luciferin / Q000138:chemical synthesis / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D005982:Glutathione Transferase / Q000737:chemistry*; D007202:Indicators and Reagents; D008163:Luminescent Measurements; D015394:Molecular Structure; D012547:Schistosoma / Q000201:enzymology; D012680:Sensitivity and Specificity
chemical_list: D007202:Indicators and Reagents; D049454:Firefly Luciferin; D005982:Glutathione Transferase; D005978:Glutathione