Lipofuscin-like fluorophores originated from malondialdehyde.
The accumulation of fluorescent age pigment or lipofuscin is a frequently observed age-associated cellular alteration in a variety of post-mitotic cells of many species. These pigments are observed within granules composed, in part, of damaged protein and lipid. In the present mini-review, I provide a comprehensive summary of fluorescent adducts originated from malondialdehyde (MDA).
Uchida
Koji
K
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. uchidak@agr.nagoya-u.ac.jp
D050197:Atherosclerosis / Q000473:pathology; D004095:Dihydropyridines / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D015227:Lipid Peroxidation / Q000502:physiology*; D008062:Lipofuscin / Q000096:biosynthesis*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008239:Lysine / Q000737:chemistry; D008315:Malondialdehyde / Q000378:metabolism*
D004095:Dihydropyridines; D005456:Fluorescent Dyes; D008062:Lipofuscin; D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D008239:Lysine