title: Kv1.1 takes a deTOR from the axon to the dendrite.
abstract: In the October 6th issue of Science, Raab-Graham et al. described two surprising findings. They discovered that local dendritic translation of Kv1.1 occurs in CA1 dendrites of rat hippocampal slices and in cultured neurons. This local translation is inhibited by NMDA receptor-mediated synaptic signaling acting through the mTOR kinase.
authors.affiliation: Department of Pharmacology, School of Medicine, University of California, Davis, Davis, California 95616, USA.
authors.forename: Eliana
authors.initials: E
authors.lastname: Clark
authors.forename: Helene
authors.initials: H
authors.lastname: Vacher
authors.forename: James S
authors.initials: JS
authors.lastname: Trimmer
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology; D051662:Kv1.1 Potassium Channel / Q000502:physiology*; D008954:Models, Biological; D009474:Neurons / Q000166:cytology; D011494:Protein Kinases / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D058570:TOR Serine-Threonine Kinases
chemical_list: D051662:Kv1.1 Potassium Channel; D011494:Protein Kinases; C546845:mTOR protein, rat; D058570:TOR Serine-Threonine Kinases