Neurologic presentation of Erdheim-Chester disease.
Erdheim-Chester disease is a rare, systemic histiocytosis that involves multiple organ systems and causes symmetric sclerosis of the metaphysis and diaphysis of the long bones. We present 2 cases and reviewed 108 patients reported in the literature who had neurologic manifestations of Erdheim-Chester disease. After eye involvement or diabetes insipidus, cerebellar symptoms were most frequently encountered, followed by tumor, headaches, cord compression, mental status change, seizures, and change in libido. A wide range of neurological symptoms can be seen in ECD. Therefore we hope the review brings more awareness about this disorder.
Brodkin
Cynthia L
CL
Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Wszolek
Zbigniew K
ZK
D000328:Adult; D000368:Aged; D002526:Cerebellar Diseases / Q000150:complications / Q000175:diagnosis; D003919:Diabetes Insipidus / Q000150:complications / Q000175:diagnosis; D003937:Diagnosis, Differential; D018450:Disease Progression; D031249:Erdheim-Chester Disease / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D015614:Histiocytosis / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000379:methods*