Transient leukocytopenia associated with a steep surge of pro-inflammatory cytokines in a patient with severe cardiogenic pulmonary edema.
Leukocytopenia can be caused by depressed production, increased peripheral destruction, or excessive peripheral pooling. Leukocyte margination is one of the mechanisms responsible for excessive peripheral pooling. A reversible leukocyte margination is caused by an increase in pro-inflammatory cytokines. However, there are limited data for this phenomenon in clinical conditions. We describe a case of unexpected transient leukocytopenia after exchanging an extracorporeal membrane oxygenation (ECMO) system used to treat severe cardiogenic pulmonary edema. To assess the cause of the leukocytopenia, the serum concentrations of pro-inflammatory cytokines and selectins were measured. The concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 were markedly, but transiently, elevated in relation to the leukocytopenia. The transient leukocytopenia with pulmonary margination appeared to be caused by a steep surge of pro-inflammatory cytokines stimulated by hypoxia/reoxygenation during the exchange of the ECMO system. This case may suggest the mechanisms responsible for leukocytopenia in the clinical entity referred to as "systemic inflammatory response syndrome"
Yamamoto
Takeshi
T
Intensive and Cardiac Care Unit, Nippon Medical School, Tokyo.
Terajima
Katsuyuki
K
Kato
Koji
K
Iwasaki
Yu-ki
YK
Miyagi
Yasuo
Y
Sato
Naoki
N
Takeda
Shinhiro
S
Tanaka
Keiji
K
Takano
Teruo
T
D002815:Chordae Tendineae; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D004417:Dyspnea / Q000209:etiology / Q000503:physiopathology; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects; D006349:Heart Valve Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism; D016209:Interleukin-8 / Q000097:blood / Q000378:metabolism; D007423:Intra-Aortic Balloon Pumping; D007970:Leukopenia / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011175:Positive-Pressure Respiration; D011654:Pulmonary Edema / Q000097:blood* / Q000209:etiology; D012422:Rupture, Spontaneous; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha