Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease.
Certain chemokines have been proposed to distinctly contribute to tumor growth, dissemination and local immune escape. Expression of the chemokine receptor CXCR4 has been linked to tumor progression in diverse tumor entities. The aim of this study was to evaluate if the expression of CXCR4 influences progression of human pancreatic cancer. CXCR4 expression of pancreatic cancer was retrospectively assessed by immunohistochemistry in 103 patients with pancreatic cancer. Intensity of CXCR4 expression was correlated with both tumor and patient characteristics. Human pancreatic cancer revealed variable intensities of CXCR4 expression. Strong CXCR4 expression was significantly associated with advanced UICC stages (P=0.03) and revealed a trend for hematogenous metastasis (P=0.09) and progressed local tumor stages (P=0.15). In summary, strong expression of CXCR4 was significantly associated with advanced pancreatic cancer.
Wehler
Thomas
T
Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany.
Wolfert
Felix
F
Schimanski
Carl C
CC
Gockel
Ines
I
Herr
Wolfgang
W
Biesterfeld
Stefan
S
Seifert
Joachim K
JK
Adwan
Hassan
H
Berger
Martin R
MR
Junginger
Theodor
T
Galle
Peter R
PR
Moehler
Markus
M
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor; D015153:Blotting, Western; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D019718:Receptors, CXCR4 / Q000096:biosynthesis*; D012189:Retrospective Studies
D014408:Biomarkers, Tumor; D019718:Receptors, CXCR4