title: Expression of NF-kappaB in Helicobacter pylori infection.
abstract: Helicobacter pylori colonizes the gastric mucosa in humans and causes chronic gastritis. NF-kappaB has a key role as a mediator in mucosal inflammation. In this study, we examined the expression of NF-kappaB in the antral epithelial cells of H. pylori-infected and H. pylori-uninfected biopsies and examined these processes in relationship with grade and activity of gastritis, density of H. pylori, presence of the intestinal metaplasia, and atrophy. Fifty biopsies (35 H. pylori-positive patients and 15 H. pylori-negative controls) were studied. NF-kappaB immunohistochemical stain was performed. NF-kappaB activity in H. pylori-infected biopsies were markedly enhanced compared with uninflamed biopsies (P = 0.001). We also found positive correlation NF-kappaB expression with severity of gastritis (according to Sydney score) (P = 0.001), activity of gastritis (P = 0.046) and H. pylori load (P < 0.001), and atrophy (P = 0.004). We did not find a significant relationship between NF-kappaB and the presence of intestinal metaplasia (P = 0.355). These findings suggested that expression of NF-kappaB has an important role in H. pylori gastritis.
authors.affiliation: Department of Pathology, Adnan Menderes Universty School of Medicine, Aydin, Turkey. fdoger@adu.edu.tr
authors.forename: Furuzan Kacar
authors.initials: FK
authors.lastname: Doger
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Meteoglu
authors.forename: Esra
authors.initials: E
authors.lastname: Ozkara
authors.forename: Zehra Kocakaya
authors.initials: ZK
authors.lastname: Erkul
authors.forename: Pinar
authors.initials: P
authors.lastname: Okyay
authors.forename: Vahit
authors.initials: V
authors.lastname: Yükselen
mesh_terms: D001284:Atrophy / Q000473:pathology; D001706:Biopsy; D004847:Epithelial Cells / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D015964:Gene Expression Regulation, Bacterial; D016481:Helicobacter Infections / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008679:Metaplasia / Q000473:pathology; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D016328:NF-kappa B