[SNP polymorphism of LGALS3BP gene in patients with benign and malignant thyroid tumours].
BACKGROUND
The aim of the study was estimation of occurrence of SNP (single nucleotide polymorphism) sites in LGALS3BP gene in patients with benign and malignant thyroid tumors and analysis of correlation between their frequency and the histological type of thyroid lesions.


METHODS
The studied group consisted of 58 patients, 24 with papillary thyroid carcinomas, 19 with nodular goiters and 15 with follicular adenomas. Control group included 180 healthy volunteers. Four different SNP polymorphisms were analysed in PCR products using the SNaPshot test, on genetic analyser ABI Prism 310; these can be found in NCBI database under rs numbers: 1803938 (a/g), 11024 (g/c), 1801463 (a/c) and 1131516 (c/t).


RESULTS
In all patients analysis of SNP sites revealed: lack of polymorphism in a/g rs 18039380; polymorphism identical to database in g/c rs 11024 and polymorphism different from database in a/g rs 1801463 and c/g rs 131516. There were no significant differences between patients with thyroid lesions and group of healthy controls.


CONCLUSIONS
Single nucleotide polymorphism (SNP) of LGALS3BP gene (found in NCBI) database are not characteristic for papillary thyroid cancer, follicular adenomas and nodular goiter.
Łukieńczuk
Tadeusz
T
I Department of General, Gastroenterologicaland Endocrinological Surgery, Faculty of Public Health, Medical University Wroclaw, J. Poniatowskiego 2, Wroclaw.
Kaliszewski
Krzysztof
K
Zołedziewska
Magdalena
M
Jonkisz
Anna
A
Dmochowska
Grazyna
G
Dobrut
Mirosław
M
Rogoliński
Jacek
J
Dobosz
Tadeusz
T
D000236:Adenoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006023:Glycoproteins / Q000235:genetics*; D006044:Goiter, Nodular / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013964:Thyroid Neoplasms / Q000235:genetics*; D016326:Extracellular Matrix Proteins
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D006023:Glycoproteins; C081856:LGALS3BP protein, human; D016326:Extracellular Matrix Proteins