title: Comparative study of chemical constituents of rhubarb from different origins.
abstract: A comparative study of the pharmacologically active constituents of 24 rhubarb samples, which were identified genetically as Rheum tanguticum, 3 intraspecies groups of R. palmatum and R. officinale, was conducted using reversed-phase high performance liquid chromatography (HPLC) methods. Thirty compounds belonging to anthraquinones, anthraquinone glucosides, dianthrones, phenylbutanones, stilbenes, flavan-3-ols, procyanidins, galloylglucoses, acylglucoses, gallic acid, and polymeric procyanidins were analyzed quantitatively. The drug samples derived from the same botanical source showed similar chromatographic profiles, and the comparable specific shape that appeared in the 10-directed radar graphs constructed on the basis of the results of quantitative analysis indicated the relationship between chemical constituent patterns and genetic varieties of rhubarb samples.
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama, Japan. katsukok@inm.u-toyama.ac.jp
authors.forename: Katsuko
authors.initials: K
authors.lastname: Komatsu
authors.forename: Yorinobu
authors.initials: Y
authors.lastname: Nagayama
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yun
authors.initials: Y
authors.lastname: Ling
authors.forename: Shao-Qing
authors.initials: SQ
authors.lastname: Cai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Omote
authors.forename: Meselhy Ragab
authors.initials: MR
authors.lastname: Meselhy
mesh_terms: D000873:Anthracenes / Q000032:analysis; D000880:Anthraquinones / Q000032:analysis; D002074:Butanones / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005419:Flavonoids / Q000032:analysis; D005707:Gallic Acid / Q000032:analysis; D005960:Glucosides / Q000032:analysis; D047348:Hydrolyzable Tannins / Q000032:analysis; D015394:Molecular Structure; D044945:Proanthocyanidins / Q000032:analysis; D012250:Rheum / Q000737:chemistry* / Q000145:classification* / Q000235:genetics; D012680:Sensitivity and Specificity; D013045:Species Specificity; D013237:Stereoisomerism; D013267:Stilbenes / Q000032:analysis
chemical_list: D000873:Anthracenes; D000880:Anthraquinones; D002074:Butanones; D005419:Flavonoids; D005960:Glucosides; D047348:Hydrolyzable Tannins; D044945:Proanthocyanidins; D013267:Stilbenes; C404987:flavan-3-ol; C060474:glucogallin; D005707:Gallic Acid