title: Alzheimer's disease and type 2 diabetes mellitus: the cholinesterase connection?
abstract: Alzheimer's disease and type 2 diabetes mellitus tend to occur together. We sought to identify protein(s) common to both conditions that could suggest a possible unifying pathogenic role. Using human neuronal butyrylcholinesterase (AAH08396.1) as the reference protein we used BLAST Tool for protein to protein comparison in humans. We found three groups of sequences among a series of 12, with an E-value between 0-12, common to both Alzheimer's disease and diabetes: butyrylcholinesterase precursor K allele (NP_000046.1), acetylcholinesterase isoform E4-E6 precursor (NP_000656.1), and apoptosis-related acetylcholinesterase (1B41|A). Butyrylcholinesterase and acetylcholinesterase related proteins were found common to both Alzheimer's disease and diabetes; they may play an etiological role via influencing insulin resistance and lipid metabolism.
authors.affiliation: Endocrine and Diabetes Centre, 15-12-16 Krishnanagar, Visakhapatnam 530 002, India. sridharvizag@gmail.com
authors.forename: Gumpeny Ramachandra
authors.initials: GR
authors.lastname: Sridhar
authors.forename: Hanuman
authors.initials: H
authors.lastname: Thota
authors.forename: Appa Rao
authors.initials: AR
authors.lastname: Allam
authors.forename: Changalasetty
authors.initials: C
authors.lastname: Suresh Babu
authors.forename: Akula
authors.initials: A
authors.lastname: Siva Prasad
authors.forename: Ch
authors.initials: Ch
authors.lastname: Divakar
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry / Q000235:genetics*; D000544:Alzheimer Disease / Q000150:complications* / Q000201:enzymology; D017209:Apoptosis / Q000502:physiology; D002091:Butyrylcholinesterase / Q000737:chemistry / Q000235:genetics*; D019295:Computational Biology; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000209:etiology*; D004792:Enzyme Precursors / Q000235:genetics; D006801:Humans; D009474:Neurons / Q000201:enzymology; D016415:Sequence Alignment
chemical_list: D004792:Enzyme Precursors; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase