title: Amuchina 10% solution, safe antiseptic for preventing infections of exit-site of Tenckhoff catheters, in the pediatric population of a dialysis program.
abstract: Although, decreasing in incidence with the disconnection systems, the first complication is still peritonitis in patients with chronic renal failure and the second is infection of Tenckhoff catheter exit-site. All efforts made to diminish the frequency of exit-site infection lower the possibility of peritonitis. The pediatric population is well-known to have a major risk of infectious complications, and making easy and safe the care of the exit-site will prevent the peritonitis that follows. The aim of the study was to evaluate the efficacy of the Amuchina 10% solution vs. pH neutral soap in children with chronic renal failure, on preventing exit-site infection. There were 60 patients who were assigned randomly to one of two groups. One group used Amuchina 10% solution for the daily cleaning of the exit-site, and the other used pH neutral soap, with 14 months of follow-up. Before the study they have to be free of infection for at least 30 days. All were taught by the same nurse how to clean their exit-site. Groups were almost identical in years, sex, and time on dialysis. We had nine infections in the soap group and none in the Amuchina 10% solution group, with an OR: 17 (p = 0.004). From these nine infections, the bacteria isolated were: 4 (13%) were caused by Pseudomona aeruginosa, 1 (3.3%) by Staphylococcus aureus, coagulase-positive staphylococci in 2 (6.6%) and Serratia marcensens in 1 (3.3%). In conclusion, Amuchina 10% solution is effective in preventing infection on the exit-site, without any secondary topical reaction.
authors.affiliation: Hospital de Pediatria, Centro Medico Nacional 'Siglo XXI', Instituto Mexicano del Seguro Social, Mexico, D.F., Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Mendoza-Guevara
authors.forename: F
authors.initials: F
authors.lastname: Castro-Vazquez
authors.forename: A
authors.initials: A
authors.lastname: Aguilar-Kitsu
authors.forename: A
authors.initials: A
authors.lastname: Morales-Nava
authors.forename: F
authors.initials: F
authors.lastname: Rodriguez-Leyva
authors.forename: J L
authors.initials: JL
authors.lastname: Sanchez-Barbosa
mesh_terms: D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002408:Catheters, Indwelling / Q000382:microbiology; D002648:Child; D004866:Equipment Contamination / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006997:Hypochlorous Acid / Q000627:therapeutic use*; D015994:Incidence; D017053:Infection Control / Q000379:methods* / Q000706:statistics & numerical data; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D010538:Peritonitis / Q000453:epidemiology / Q000517:prevention & control*; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000517:prevention & control; D016868:Serratia Infections / Q000453:epidemiology / Q000517:prevention & control; D017592:Skin Care / Q000379:methods; D012915:Soaps; D012965:Sodium Chloride / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000517:prevention & control
chemical_list: C057052:Amuchina; D000891:Anti-Infective Agents, Local; D012915:Soaps; D012965:Sodium Chloride; D006997:Hypochlorous Acid