title: Sculptra: the new three-dimensional filler.
abstract: Sculptra, the synthetic injectable poly-l-lactic acid (PLLA), is a revolutionary three-dimensional filler lasting 18 to 24 months. This unique volumizing agent is best used to globally restore volume to the lower two thirds of the face in patients who have lipoatrophy. Sculptra is a biocompatible, biodegradable, and nonimmunogenic derivative of the alpha-hydroxy-acid family. The size and the slow degradation kinetics of PLLA microparticles act as a stimulus for collagen production, providing lasting volume enhancement in lipoatrophy patients.
authors.affiliation: Skin Institute of New Orleans, 2633 Napoleon Avenue, Suite 815, New Orleans, LA 70115, USA. rshermanmd@cox.net
authors.forename: Richard N
authors.initials: RN
authors.lastname: Sherman
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D001284:Atrophy / Q000188:drug therapy / Q000473:pathology; D002482:Cellulose / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005145:Face; D017408:Guidelines as Topic; D006801:Humans; D007279:Injections, Subcutaneous; D019344:Lactic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008353:Mannitol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011108:Polymers / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012060:Rejuvenation
chemical_list: C482305:New-Fill; D011108:Polymers; D019344:Lactic Acid; D008353:Mannitol; D002482:Cellulose