title: [Autoantibodies against alpha1 adrenergic receptor related with cardiac remodeling in hypertensive patients by clinical observation].
abstract: OBJECTIVE
  To investigate the effects of autoantibodies against alpha(-) adrenergic receptor on cardiac remodeling in patients with hypertension.
  
  
  METHODS
  Five hundred and fifty three patients with hypertension in our hospital were selected. The autoantibodies against alpha(1) adrenergic receptor in sera of donor were detected by ELISA, and the results of echocardiography were recorded. By multiple logistic regressions, the risk factors were analyzed on left ventricular enlargement of hypertension.
  
  
  RESULTS
  The percentage of autoantibodies against alpha(1) adrenergic receptor positive was 32.3% (179/553). There were significant difference between the positive group and negative group on the ratio of left atrial enlargement (53.6%, 44.3%, respectively; P < 0.05) and left ventricular enlargement (12.8%, 6.1%, respectively; P < 0.01). The result of regression analysis demonstrated that 4 risk factors were related to left ventricular enlargement, including male, course of disease, heart rate (HR) and autoantibodies against alpha(1) adrenergic receptor in the serum (all P < 0.05).
  
  
  CONCLUSIONS
  The autoantibodies against alpha(1) adrenergic receptor have a relationship with left ventricular enlargement of hypertension. Patients with the activity of autoantibodies against alpha(1) adrenergic might contribute to predict cardiac remodeling.
authors.affiliation: Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science Technology, Wuhan 430022, China.
authors.forename: Zheng-zai
authors.initials: ZZ
authors.lastname: Li
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Liao
authors.forename: Zi-hua
authors.initials: ZH
authors.lastname: Zhou
authors.forename: Yu-miao
authors.initials: YM
authors.lastname: Wei
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Xiong-bing
authors.initials: XB
authors.lastname: Du
authors.forename: Yan-xiang
authors.initials: YX
authors.lastname: Sun
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000276:immunology / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018340:Receptors, Adrenergic, alpha-1 / Q000276:immunology*; D020257:Ventricular Remodeling / Q000276:immunology
chemical_list: D001323:Autoantibodies; D018340:Receptors, Adrenergic, alpha-1