title: [Exercise in outpatient complex rehabilitation and secondary prophylaxis in patients with ischemic heart disease after acute coronary events (a cooperative trial in Russia)].
abstract: OBJECTIVE
  To assess efficacy of early and long-term exercise in patients with ischemic heart disease (IHD) after acute coronary events (acute myocardial infarction--AMI, unstable angina--UA, coronary artery bypass grafting--CABG) in wide outpatient medical practice of Russia.
  
  
  METHODS
  Three to eight weeks after the acute coronary event (ACE) 373 patients from different clinics of RF regions were randomized into two groups: the study group (n = 188) and a control one (n = 185). Both groups received standard therapy, the study group performed also a special exercise program (moderate exercise for maximum 1 hour 3 times a week for a year). The efficacy of the treatment was assessed by clinical, device and biochemical findings during 6-month follow-up.
  
  
  RESULTS
  Physical work capacity, total amount of performed work (PW) in stress test rose in the study group by 26.5% (p < 0.01) and 59.4% (p < 0.01), respectively; HRmax and BPSmax x HRmax increased by 6.4 and 9.8%, respectively, p < 0.01); PW/Hrpeak rose by 48.6% (p < 0.01), PW/DP peak--by 45.9% (p < 0.01). Left ventricular ejection fraction increased by 5.6% (p < 0.05), LV stroke volume--by 3.4% (p < 0.05). In 6 months, controls demonstrated a 4.7% (p < 0.05) rise in HDLP cholesterol, total cholesterol lowered in the study group by 6.4% (p < 0.01), body mass index--by 1.9%, number of anginal attacks--by 0.9%.
  
  
  CONCLUSIONS
  The proposed exercise program is effective and can be applied in outpatients after acute coronary events. The program can be also used as a method of secondary prophylaxis as it lowers total cholesterol, atherogenic index and body mass index.
authors.forename: D M
authors.initials: DM
authors.lastname: Aronov
authors.forename: V B
authors.initials: VB
authors.lastname: Krasnitskiĭ
authors.forename: M G
authors.initials: MG
authors.lastname: Bubnova
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Posdniakov
authors.forename: D V
authors.initials: DV
authors.lastname: Ioseliani
authors.forename: A N
authors.initials: AN
authors.lastname: Shchegol'kov
authors.forename: G G
authors.initials: GG
authors.lastname: Efremushkin
authors.forename: I V
authors.initials: IV
authors.lastname: Osipova
authors.forename: S F
authors.initials: SF
authors.lastname: Guliaeva
authors.forename: S V
authors.initials: SV
authors.lastname: Mal'chikova
authors.forename: E V
authors.initials: EV
authors.lastname: Kazakevich
authors.forename: N P
authors.initials: NP
authors.lastname: Liamina
authors.forename: I N
authors.initials: IN
authors.lastname: Riamzina
authors.forename: L N
authors.initials: LN
authors.lastname: Mingazetdinova
mesh_terms: D004452:Echocardiography; D004562:Electrocardiography; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000517:prevention & control* / Q000534:rehabilitation*; D010045:Outpatients; D015995:Prevalence; D012426:Russia / Q000453:epidemiology; D013318:Stroke Volume; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000502:physiology