title: Methods and protocols for prediction of immunogenic epitopes.
abstract: T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the identification of T-cell epitopes to specific MHC alleles. This article examines existing computational strategies for the study of peptide/MHC interactions. The most important bioinformatics tools and methods with relevance to the study of peptide/MHC interactions have been reviewed. We have also provided guidelines for predicting antigenic peptides based on the availability of existing experimental data.
authors.affiliation: Institute of Infocomm Research, Singapore.
authors.forename: Joo Chuan
authors.initials: JC
authors.lastname: Tong
authors.forename: Tin Wee
authors.initials: TW
authors.lastname: Tan
authors.forename: Shoba
authors.initials: S
authors.lastname: Ranganathan
mesh_terms: D000465:Algorithms; D000936:Antigen-Antibody Complex / Q000032:analysis / Q000276:immunology*; D001665:Binding Sites; D018604:Epitope Mapping / Q000379:methods*; D018984:Epitopes, T-Lymphocyte / Q000032:analysis / Q000737:chemistry / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis / Q000737:chemistry / Q000276:immunology*; D010455:Peptides / Q000032:analysis / Q000276:immunology*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*
chemical_list: D000936:Antigen-Antibody Complex; D018984:Epitopes, T-Lymphocyte; D006680:HLA Antigens; D010455:Peptides