Early postoperative response of cytokines in liver transplant recipients.
We evaluated the early postoperative response of several cytokines (IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma) prior to liver transplantation (T(0)) as well as 1, 6, and 12 hours and 1, 2, 3, 5, and 7 days afterward. Cytokine concentrations were correlated with serum levels of bilirubin as a predictor of postoperative complications. Cytokine levels were determined in plasma samples from 16 liver transplant recipients (13 men, 3 women) aged 43 to 61 years. IL-6 and IL-10 reached their maximum concentrations 1 hour after transplantation. Each increase in IL-6 correlated to a rise in IL-10. IL-2, IL-4, TNF-alpha, and IFN-gamma had a particular time-course for each patient studied. Bilirubin fell to almost normal values but not in cases of postoperative complications, where IL-6 showed values four times higher compared to those of liver transplant recipients who did not show postoperative complications. IL-6 and IL-10 plasma concentrations and serum bilirubin level might be useful as a predictive factor of postoperative complications in liver transplant recipients.
Hassan
L
L
Experimental Surgery Research Unit, Virgen de las Nieves University Hospital, Granada, Spain.
Bueno
P
P
Ferrón-Celma
I
I
Ramia
J M
JM
Garrote
D
D
Muffak
K
K
Barrera
L
L
Villar
J M
JM
García-Navarro
A
A
Mansilla
A
A
Gomez-Bravo
M A
MA
Bernardos
A
A
Ferrón
J A
JA
D000328:Adult; D001663:Bilirubin / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D011184:Postoperative Period; D012016:Reference Values; D013030:Spain; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D001663:Bilirubin