title: Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa.
abstract: The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.
authors.affiliation: 1Centre of Applied Biomedical Research (CRBA), S Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy. giulia.piazzi@yahoo.it
authors.forename: G
authors.initials: G
authors.lastname: Piazzi
authors.forename: P
authors.initials: P
authors.lastname: Paterini
authors.forename: C
authors.initials: C
authors.lastname: Ceccarelli
authors.forename: M A
authors.initials: MA
authors.lastname: Pantaleo
authors.forename: G
authors.initials: G
authors.lastname: Biasco
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000032:analysis; D012007:Rectum / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012333:RNA, Messenger; D066246:ErbB Receptors