Cyclin D1 functions in cell migration.
Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its upregulation by Ras, Rho, Src, and other genes that drive malignant development, the new findings suggest that cyclin D1 may have a central role in mediating invasion and metastasis of cancer cells by controlling Rho/ROCK signaling and matrix deposition of TSP-1.
Li
Zhiping
Z
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Wang
Chenguang
C
Prendergast
George C
GC
Pestell
Richard G
RG
D000818:Animals; D002453:Cell Cycle; D002465:Cell Movement; D019938:Cyclin D1 / Q000378:metabolism / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000378:metabolism; D015398:Signal Transduction; D019700:Thrombospondin 1 / Q000378:metabolism*; D014158:Transcription, Genetic; D054460:rho-Associated Kinases
D047908:Intracellular Signaling Peptides and Proteins; D016160:Retinoblastoma Protein; D019700:Thrombospondin 1; D019938:Cyclin D1; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases