title: Primary chondrosarcoma in the liver of a dog.
abstract: Primary chondrosarcoma was found in the quadrate lobe of the liver of a 6-year-old, intact, male Golden Retriever. At 6 months after partial hepatectomy, recurrence in the liver occurred. The dog died of its systemic metastases 10 months thereafter. Histologically, the hepatic mass revealed neoplastic chondrocytes with abundant chondroid matrix, and there were few myxoid areas where the cellularity and pleomorphism of the neoplastic cells were more prominent. The neoplastic cells were positive for periodic acid-Schiff and were immunohistochemically positive for vimentin and S-100 protein; the matrix was deeply stained for alcian blue and was metachromatic for toluidine blue stain. This tumor might be derived from pluripotent mesenchymal cells in the connective tissue of the liver. To the best of our knowledge, in all mammalians, including humans, this is the first report of extraskeletal chondrosarcoma primarily arising in the liver.
authors.affiliation: Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, 180-8602 Tokyo, Japan. kimimasa@nvlu.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Chikata
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Katayama
authors.forename: S
authors.initials: S
authors.lastname: Yanagisawa
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.forename: I
authors.initials: I
authors.lastname: Yamane
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D002813:Chondrosarcoma / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008113:Liver Neoplasms / Q000473:pathology / Q000662:veterinary*; D008297:Male