Thymus exclusivity: all the right conditions for T cells.
A fraction of primitive "lymphoid" precursors retain plasticity for myeloid differentiation. In this issue of Immunity, Laiosa et al. describe that Notch-Delta signals can protect thymic precursors from reprogramming into the myeloid lineage, antagonizing the enforced myeloid transcription factors such as PU.1 and C/EBPalpha.
Iwasaki
Hiromi
H
Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Akashi
Koichi
K
D000818:Animals; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000276:immunology / Q000378:metabolism; D051880:Receptors, Notch / Q000276:immunology / Q000378:metabolism; D017465:Receptors, Opioid, delta / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology; D015534:Trans-Activators / Q000276:immunology / Q000378:metabolism; D000099232:Proto-Oncogene Protein Spi-1
D022763:CCAAT-Enhancer-Binding Protein-alpha; D011518:Proto-Oncogene Proteins; D051880:Receptors, Notch; D017465:Receptors, Opioid, delta; D015534:Trans-Activators; D000099232:Proto-Oncogene Protein Spi-1