title: Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes.
abstract: Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder - RGS4, PRODH, COMT and GRK3 - in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p<0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.
authors.forename: Diana Pinto
authors.initials: DP
authors.lastname: Prata
authors.forename: Gerome
authors.initials: G
authors.lastname: Breen
authors.forename: Janet
authors.initials: J
authors.lastname: Munro
authors.forename: Maggie
authors.initials: M
authors.lastname: Sinclair
authors.forename: Sarah
authors.initials: S
authors.lastname: Osborne
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Robert
authors.initials: R
authors.lastname: Kerwin
authors.forename: David
authors.initials: D
authors.lastname: St Clair
authors.forename: David A
authors.initials: DA
authors.lastname: Collier
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D054770:G-Protein-Coupled Receptor Kinase 3; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011394:Proline Oxidase / Q000235:genetics*; D020710:RGS Proteins / Q000235:genetics*; D051552:beta-Adrenergic Receptor Kinases / Q000235:genetics*
chemical_list: D020710:RGS Proteins; C098799:RGS4 protein; D011394:Proline Oxidase; D002394:Catechol O-Methyltransferase; D054770:G-Protein-Coupled Receptor Kinase 3; C517848:GRK3 protein, human; D051552:beta-Adrenergic Receptor Kinases