Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors.
An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with alpha-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases.
Sakamoto
Jun-Ichi
J
Division of Materials Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan.
Koyama
Tetsuo
T
Miyamoto
Daisei
D
Yingsakmongkon
Sangchai
S
Hidari
Kazuya I P J
KI
Jampangern
Wipawee
W
Suzuki
Takashi
T
Suzuki
Yasuo
Y
Esumi
Yasuaki
Y
Hatano
Ken
K
Terunuma
Daiyo
D
Matsuoka
Koji
K
D050091:Dendrimers; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D053118:Influenza A Virus, H1N1 Subtype / Q000201:enzymology; D053122:Influenza A Virus, H3N2 Subtype / Q000201:enzymology; D009980:Influenza A virus / Q000201:enzymology*; D008968:Molecular Conformation; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization
D050091:Dendrimers; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D009439:Neuraminidase