title: Stress response in rat brain after different durations of noise exposure.
abstract: The alteration in the levels of plasma corticosterone, brain norepinephrine (NE), and expression of brain heat shock proteins (Hsp70) after different durations of noise exposure (acute, 1 day; sub-acute, 15 days; chronic, 30 days) has been studied to analyze their role in combating time-dependent stress effects of noise. Broadband white noise (100dB) exposure to male Wistar albino rats significantly increased the levels of plasma corticosterone and NE in all three durations of noise exposure. The sustained increase observed in their levels in the chronic group suggests that animals are not getting adapted to noise even after 30 days of exposure. The important role of Hsp70 in combating noise induced stress is evident from the significant increase in its expression after chronic exposure, while there was a reciprocal decrease in the NE and corticosterone when compared with their levels after acute and sub-acute noise exposure. This clearly indicates that the time-dependent stress response to noise exposure is a complex mechanism involving highly interconnected systems such as hypothalamo-pituitary-adrenal (HPA) axis, heat shock proteins and may have serious implications in vital organs, particularly in the brain when there is a prolonged noise exposure.
authors.affiliation: Department of Physiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India. drjsamson@hotmail.com
authors.forename: James
authors.initials: J
authors.lastname: Samson
authors.forename: Rathinasamy
authors.initials: R
authors.lastname: Sheeladevi
authors.forename: Rajan
authors.initials: R
authors.lastname: Ravindran
authors.forename: Manohar
authors.initials: M
authors.lastname: Senthilvelan
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D003345:Corticosterone / Q000097:blood; D004597:Electroshock / Q000009:adverse effects; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D008297:Male; D009622:Noise; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D018840:HSP70 Heat-Shock Proteins; D003345:Corticosterone; D009638:Norepinephrine