Effects of methamphetamine on cortisone concentration, NK cell activity and mitogen response of T-lymphocytes in female cynomolgus monkeys.
As a model for studying methamphetamine (MAP) abuse, which has become a social problem in Japan, we investigated the changes in serum cortisone, NK cell activity and mitogenic response of T-lymphocytes after a single injection of MAP (3.0 mg/kg) in female cynomolgus monkeys. Serum cortisol concentration was significantly elevated to 2.66 times pre-injection levels at 6 h post-injection, and the effect was still observed 24 h later. NK cell activity was significantly elevated at 6 h after MAP injection, but at 24 h after injection had dropped markedly to 49.5% of baseline. Mitogen (PHA) response of lymphocytes was elevated when MAP was injected, and this increased level continued up to 24 h. We speculate that the transient increase in NK cell activity followed by a distinct drop, as well as the changes in T-lymphocytes, may be strongly related to the cortisone concentration.
Saito
Masayoshi
M
Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yamaguchi
Takao
T
Kawata
Tetsuya
T
Ito
Hisao
H
Kanai
Takao
T
Terada
Masaru
M
Yokosuka
Makoto
M
Saito
Toru R
TR
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001772:Blood Cell Count; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003348:Cortisone / Q000097:blood*; D005260:Female; D013287:Illicit Drugs / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008252:Macaca fascicularis; D008694:Methamphetamine / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects*
D000697:Central Nervous System Stimulants; D013287:Illicit Drugs; D010835:Phytohemagglutinins; D008694:Methamphetamine; D003348:Cortisone