title: Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors.
abstract: An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with alpha-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases.
authors.affiliation: Division of Materials Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Sakamoto
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Koyama
authors.forename: Daisei
authors.initials: D
authors.lastname: Miyamoto
authors.forename: Sangchai
authors.initials: S
authors.lastname: Yingsakmongkon
authors.forename: Kazuya I P J
authors.initials: KI
authors.lastname: Hidari
authors.forename: Wipawee
authors.initials: W
authors.lastname: Jampangern
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Esumi
authors.forename: Ken
authors.initials: K
authors.lastname: Hatano
authors.forename: Daiyo
authors.initials: D
authors.lastname: Terunuma
authors.forename: Koji
authors.initials: K
authors.lastname: Matsuoka
mesh_terms: D050091:Dendrimers; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D053118:Influenza A Virus, H1N1 Subtype / Q000201:enzymology; D053122:Influenza A Virus, H3N2 Subtype / Q000201:enzymology; D009980:Influenza A virus / Q000201:enzymology*; D008968:Molecular Conformation; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D050091:Dendrimers; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D009439:Neuraminidase