Condensation of alpha-aroylketene dithioacetals and 2-hydroxyarylaldehydes results in facile synthesis of a combinatorial library of 3-aroylcoumarins.
A facile, convenient, efficient, and high yielding synthesis of a combinatorial library of 3-aroylcoumarins has been developed by the condensation of easily available alpha-aroylketene dithioacetals (AKDTAs) and 2-hydroxybenzaldehydes (salicylaldehydes)/2-hydroxy-1-naphthaldehyde in the presence of catalytic amount of piperidine in THF reflux. The condensation of ferrocene derived alpha-aroylketene dithioacetal and 2-hydroxybenzaldehyde furnished coumarin installed on a ferrocene platform.
Rao
H Surya Prakash
HS
Department of Chemistry, Pondicherry University, Pondicherry 605 014, India. hspr@yahoo.com
Sivakumar
S
S
D000080:Acetals / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000080:Acetals; D000447:Aldehydes; D003374:Coumarins