[Effect of paraaminobenzoic acid on interleukine-6 production in patients with herpetic keratitis].
The purpose of the study was to compare the effect of para-aminobenzoic acid (PABA) (actipol) on tear interleukin-6 (IL-6) levels in patients with herpetic keratitis and in peripheral blood cells of volunteers in vitro. Enzyme immunoassay was used to measure lacrimal fluid IL-6 levels in the actipol and acyclovir groups before and 1, 2, 3, 4, and 7-8 days after therapy and after clinical recovery in 30 patients with herpetic keratitis. A control group comprised apparently healthy volunteers (n=13, 26 eyes) who used actipol instillations into the conjunctival sac 4-5 times a day. The spontaneous production of cytokines and their production in response to the induction with different PABA concentrations (0.001, 0.01, 0.1, and 10 microkg/ml) were studied on peripheral blood cells taken from 9 volunteers. In the patients with herpetic, actipol was found to reduce and normalize tear IL-6 levels while acyclovir failed to produce this effect. In the healthy individuals, actipol did not affect IL-6 production in the anterior segment of the eye. All study PABA concentrations exerted a modulating effect on the production of IL-6 in the peripheral blood cells in vitro.
Akberova
S I
SI
Tazulakhova
E B
EB
Musaev Galbinur
P I
PI
Mamedova
V M
VM
D010129:4-Aminobenzoic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007124:Immunoenzyme Techniques; D015850:Interleukin-6 / Q000096:biosynthesis*; D016849:Keratitis, Herpetic / Q000188:drug therapy* / Q000378:metabolism; D009883:Ophthalmic Solutions; D013666:Tears / Q000187:drug effects / Q000378:metabolism*; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000627:therapeutic use*
D000998:Antiviral Agents; D015850:Interleukin-6; D009883:Ophthalmic Solutions; D014803:Vitamin B Complex; D010129:4-Aminobenzoic Acid; D000212:Acyclovir