title: Acute cortisol administration reduces subjective fatigue in healthy women.
abstract: Treatment with cortisol has been found to decrease fatigue and increase feelings of vigor in both patients and healthy male subjects. We obtained self-reports of mood before 35 mg cortisol or placebo ingestion, 70 min later, and after the healthy female subjects performed cognitive tasks for 1 h in a double-blind within-subject study. Cortisol decreased fatigue, increased vigor, and tended to decrease tension. Effects on fatigue were largest after task performance, when fatigue had increased, suggesting that improvement of fatigue by cortisol is observed when subjects are fatigued. This is the first study to demonstrate improvements in fatigue in healthy female subjects; this is particularly relevant because of the high prevalence of hypocortisolimic fatigue syndromes in women and recent evidence that many psychiatric disorders may involve stress-induced hypocortisolemia that is responsive to cortisol replacement.
authors.affiliation: Department of Experimental and Work Psychology, University of Groningen, 9712 TS Groningen, The Netherlands. mtops@darkwing.uoregon.edu
authors.forename: Mattie
authors.initials: M
authors.lastname: Tops
authors.forename: Jacobien M
authors.initials: JM
authors.lastname: van Peer
authors.forename: Albertus A
authors.initials: AA
authors.lastname: Wijers
authors.forename: Jakob
authors.initials: J
authors.lastname: Korf
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000627:therapeutic use*; D004311:Double-Blind Method; D005221:Fatigue / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000627:therapeutic use*; D008597:Menstrual Cycle / Q000502:physiology / Q000523:psychology; D008875:Middle Aged; D011597:Psychomotor Performance / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone