title: Influence of static magnetic field on cadmium toxicity: study of oxidative stress and DNA damage in rat tissues.
abstract: In the present study, we investigated the effect of co-exposure to static magnetic field (SMF) and cadmium (Cd) on the biochemical parameters, antioxidant enzymes activity and DNA damage in rat tissues. Animals were treated with cadmium (CdCl(2), 40mg/L, per os) in drinking water during 4 weeks. Cd treatment induced an increase of plasma lactate dehydrogenase (LDH) and transaminases levels. Moreover, Cd treatment increased malondialdehyde (MDA) and 8-oxodGuo levels in rat tissues. However, the antioxidant enzymes activity such as the glutathione peroxidase (GPx), catalase (CAT) and the superoxide dismutase (SOD) were decreased in liver and kidney, while we noted a huge increase of hepatic and renal cadmium content. Interestingly, the combined effect of SMF (128mT, 1h/day during 30 consecutive days) and Cd (40mg/L, per os) decreased the GPx and CAT activities in liver compared to cadmium treated group. However, the association between SMF and Cd failed to alter transaminases, MDA and 8-oxodGuo concentration. Cd treatment altered antioxidant enzymes and DNA in liver and kidney of rats. Moreover, SMF associated to Cd disrupt this antioxidant response in liver compared to Cd-treated rats.
authors.affiliation: Laboratoire de Physiologie Intégrée Faculté des Sciences de Bizerte, 7021 Jarzouna, Tunisia.
authors.forename: Salem
authors.initials: S
authors.lastname: Amara
authors.forename: Hafedh
authors.initials: H
authors.lastname: Abdelmelek
authors.forename: Catherine
authors.initials: C
authors.lastname: Garrel
authors.forename: Pascale
authors.initials: P
authors.lastname: Guiraud
authors.forename: Thierry
authors.initials: T
authors.lastname: Douki
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Ravanat
authors.forename: Alain
authors.initials: A
authors.lastname: Favier
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sakly
authors.forename: Khémais
authors.initials: K
authors.lastname: Ben Rhouma
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002104:Cadmium / Q000633:toxicity*; D002105:Cadmium Poisoning; D004249:DNA Damage; D008280:Magnetics; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002104:Cadmium