Allergic eosinophilic esophagitis.
Allergic eosinophilic esophagitis is an increasingly recognized disease in various parts of the world. The clinical presentation mimics other gastrointestinal diseases, especially gastroesophageal reflux disease, making endoscopic examination and histological evaluation of esophageal mucosal biopsies crucial to accurate diagnosis. The pathogenesis likely involves allergen-initiated, TH2-dependent, IL-5 mediated infiltration of eosinophilis into the esophageal mucosa. Therapies currently favored include dietary modifications and use of corticosteroids.
Bax
Kevin C
KC
Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Indianapolis, Indiana 46202-5225, USA.
Gupta
Sandeep K
SK
D002648:Child; D016145:Endoscopy, Digestive System; D004802:Eosinophilia / Q000503:physiopathology*; D050782:Esophageal pH Monitoring; D004941:Esophagitis / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications