Anaplasma phagocytophilum subverts tick salivary gland proteins.
Anaplasma phagocytophilum is a bacterium that is transmitted by Ixodes spp. ticks, in which it resides in salivary glands. Ticks inoculate the pathogen into hosts together with an array of salivary molecules that reduce host anti-tick inflammation. Sukumaran et al. recently showed that A. phagocytophilum uses a tick salivary protein, Salp16, to enhance its uptake from the host and into the salivary gland. Occupation and exploitation of tick salivary glands have implications for the maintenance and detection of A. phagocytophilum in its vector and early pathogen interactions with its hosts.
Foley
Janet
J
School of Veterinary Medicine, Department of Medicine and Epidemiology, University of California, Davis, CA 95616, USA. jefoley@ucdavis.edu
Nieto
Nathan
N
D041081:Anaplasma phagocytophilum / Q000472:pathogenicity*; D000712:Anaplasmosis / Q000382:microbiology / Q000635:transmission; D000818:Animals; D006801:Humans; D018884:Ixodes / Q000382:microbiology*; D012469:Salivary Glands / Q000382:microbiology; D012471:Salivary Proteins and Peptides / Q000502:physiology*; D017282:Tick-Borne Diseases / Q000382:microbiology / Q000635:transmission
D012471:Salivary Proteins and Peptides; C406843:Salp16 protein, Ixodes scapularis