title: A novel imaging technique as an adjunct to the in vivo diagnosis of nonmelanoma skin cancer.
abstract: BACKGROUND
  Spectrophotometric intracutaneous analysis (SIAscopy) is a light-based imaging system capable of producing rapid images of melanin, blood and collagen of the skin. Although the SIAscope has been investigated for melanoma diagnosis, no formal study has been conducted to determine its use in the diagnosis of nonmelanoma skin cancer (NMSC).
  
  
  OBJECTIVE
  A prospective study was conducted to investigate the potential for the SIAscope to diagnose NMSC.
  
  
  METHODS
  In total, 302 consecutive patients were recruited into the study, 363 lesions being scanned. Logistic regression analysis was used to construct a predictive model for NMSC diagnosis and receiver-operator characteristic curves were used to assess overall accuracy of the model.
  
  
  RESULTS
  A sensitivity of 98.0%, specificity of 95.7% and overall accuracy of 98.2% was found for NMSC diagnosis by the SIAscope model.
  
  
  CONCLUSIONS
  Results suggest that the SIAscope may be a useful adjunct in the diagnosis of NMSC.
authors.affiliation: Department of Plastic Surgery, Norfolk and Norwich University Hospital, Norwich, UK. contact@hamidtehrani.com
authors.forename: H
authors.initials: H
authors.lastname: Tehrani
authors.forename: J
authors.initials: J
authors.lastname: Walls
authors.forename: G
authors.initials: G
authors.lastname: Price
authors.forename: S
authors.initials: S
authors.lastname: Cotton
authors.forename: E
authors.initials: E
authors.lastname: Sassoon
authors.forename: P
authors.initials: P
authors.lastname: Hall
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000175:diagnosis*; D013053:Spectrophotometry / Q000379:methods