title: Copper-free synthesis of skipped diynes via cross-coupling reactions of alkynylalanes with propargylic electrophiles.
abstract: Alkynylalanes provide a new, copper-free route to skipped diynes when combined with propargylic electrophiles bearing an aluminum-complexing leaving group. The reaction is mild, efficient, and, in contrast to copper-mediated methods, highly regioselective. [reaction: see text]
authors.affiliation: SYNGENTA Crop Protection AG, Research Chemistry, CH-4002 Basel, Switzerland.
authors.forename: Jilali
authors.initials: J
authors.lastname: Kessabi
authors.forename: Renaud
authors.initials: R
authors.lastname: Beaudegnies
authors.forename: Pierre M J
authors.initials: PM
authors.lastname: Jung
authors.forename: Benjamin
authors.initials: B
authors.lastname: Martin
authors.forename: Florian
authors.initials: F
authors.lastname: Montel
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wendeborn