Small molecule directed aggregation of a heme peptide on gold: an STM study.
Microperoxidase 11 was adsorbed on Au(111) from basic aqueous solutions containing pure heme peptide and co-added stoichiometric amounts of exogenous neutral and ionic ligands. The addition of small molecules to MP11 produced different aggregate structures that were easily differentiated by STM. In the absence of a complexing agent, the MP-11 formed large clusters of metallopeptide molecules on the gold surface. With neutral imidazole in solution the MP11 aggregated into regular elongated structures (nano-épis) on the substrate. When S(2-) is used as coupling agent, single heme peptide molecules are isolated with identifiable porphyrin ring and substructure in the peptide chain.
Satterlee
James D
JD
Mazur
Ursula
U
D000042:Absorption; D002412:Cations; D006046:Gold / Q000737:chemistry*; D006418:Heme / Q000737:chemistry*; D006420:Hemeproteins / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry; D016252:Microscopy, Scanning Tunneling / Q000379:methods; D008958:Models, Molecular; D010100:Oxygen / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D010544:Peroxidases / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry
D002412:Cations; D006420:Hemeproteins; D007093:Imidazoles; D010455:Peptides; D012996:Solutions; D006418:Heme; D006046:Gold; D010544:Peroxidases; C021799:microperoxidase; D010100:Oxygen