[Case of rapid progressive interstitial pneumonia associated with primary Sjogren syndrome].
A 72-year-old woman with a dry cough and dyspnea on exertion was admitted to our hospital. A chest radiograph showed reticular opacities and volume loss in both lower lung fields. She was troubled with xerostomia and her laboratory test showed positive reaction for anti SS-A and SS-B antibody. Labial biopsy led to a diagnosis of primary Sjogren's syndrome (pSjS). Lung biopsy specimens obtained by video-assisted thoracoscopic surgery (VATS) revealed interstitial pneumonia. On the sixth postoperative day, hypoxemia acutely worsened and her chest radiograph showed widespread diffuse ground-glass attenuation. A diagnosis of acute exacerbation was made, and steroid and immunosuppressive therapy was started. In spite of intensive therapy, she died due to respiratory failure. We report a rare case of interstitial pneumonia with pSjS resulting in acute exacerbation.
Naruse
Yoshihisa
Y
Department of Respiratory Medicine, Seirei Mikatahara Hospital.
Inui
Naoki
N
Yasui
Hideki
H
Karayama
Masato
M
Yamazaki
Sawa
S
Muramatsu
Eriko
E
Uto
Tomohiro
T
Morita
Satoru
S
Tsuchiya
Tomoyoshi
T
Nakano
Yutaka
Y
Enomoto
Noriyuki
N
Imokawa
Shiro
S
Suda
Takafumi
T
Chida
Kingo
K
D000368:Aged; D001706:Biopsy / Q000009:adverse effects; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000175:diagnosis; D012131:Respiratory Insufficiency / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis; D020775:Thoracic Surgery, Video-Assisted / Q000009:adverse effects; D014057:Tomography, X-Ray Computed