title: Localized bilateral paranasal mucormycosis: a case in an immunocompetent patient.
abstract: Mucormycosis of the nasal cavity and paranasal sinuses is an uncommon opportunistic fungal infection, which often has an aggressive, life-threatening course. Patients who have this condition are generally diabetic or immunosuppressed. However, mucormycosis can also occur in immunocompetent individuals. The most effective treatment consists of reversal of the source of immunocompromise, immediate surgical debridement and administration of systemic amphotericin B. No consensus has been reached regarding the appropriate surgical treatment or the total dose of amphotericin B. We present the case of a patient suffering from localized bilateral paranasal mucormycosis who was treated by means of endoscopic sinus surgery and administration of systemic amphotericin B. We suggest that endoscopic sinus surgery is the choice of treatment for localized paranasal mucormycosis in an immunocompetent patient, and that the total dose of amphotericin B can be determined by the extent of disease and the postoperative endoscopic findings.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Pusan Paik Hospital, Pusan, South Korea. sinus4@pusanpaik.or.kr
authors.forename: Seong Kook
authors.initials: SK
authors.lastname: Park
authors.forename: Hyun
authors.initials: H
authors.lastname: Jung
authors.forename: Mi Seon
authors.initials: MS
authors.lastname: Kang
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D004724:Endoscopy; D006801:Humans; D007121:Immunocompetence; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis / Q000628:therapy; D012852:Sinusitis / Q000382:microbiology* / Q000628:therapy
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B