Effect of Catha edulis foresk (khat) extracts on male rat sexual behavior.
Khat chewing is a widespread habit that has a deep-rooted socio-cultural tradition in East Africa and in the Middle East. Although a number of investigations have been carried out using cathinone, the psychoactive component of khat, these may not wholly reflect the behavioral effects observed after administering khat in a dosage similar to those used traditionally. The aim of the present study was to evaluate the effect of sub-chronically administered khat extract with or without alcohol on sexual behavior in male rats. Adult albino wistar male rats were administered either with khat extracts (100, 200, 400mg/kg), amphetamine (1mg/kg), sildenafil (1mg/kg), ethanol (2ml/kg of 2% and 10%), or a combination of khat and ethanol (2%+10%) by intragastric gavage orally for 15 days. Khat (400mg/kg) treated rats demonstrated a statistically significant increase in all sexual parameters except in mounting frequency, intercopulatory interval and copulatory efficiency. Whereas, khat (200mg/kg) treated rats showed a statistically significant increase only in ejaculation latency (P<0.01). In marked contrast, low dose (100mg/kg) of khat extract was found to significantly reduce both mount latency (P<0.05) and intromission latency P<0.01) thereby enhancing sexual motivation/arousal in male rats. Similar results were obtained when khat extract (200mg/kg) and ethanol (10%) were administered concomitantly despite the inhibitory effect observed in male sexual behavior when administered alone. From the present study it can be concluded that higher doses of the extract inhibit sexual behavior in male rats. In contrast, low dose of the extract as well as the concurrent administration of the extract followed by ethanol was found to enhance male rat sexual motivation/arousal.
Abdulwaheb
Mohammedbirhan
M
Department of Pharmacology, Faculty of Medicine, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Makonnen
Eyasu
E
Debella
Asfaw
A
Abebe
Dawit
D
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D029754:Catha / Q000737:chemistry*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D002492:Central Nervous System Depressants; D010879:Piperazines; D010936:Plant Extracts; D011687:Purines; D013450:Sulfones; D013566:Sympathomimetics; D014665:Vasodilator Agents; D000431:Ethanol; D000068677:Sildenafil Citrate; D000661:Amphetamine