title: [A case of gastrointestinal stromal tumor with liver and bone metastases effectively treated with radiofrequency ablation and imatinib mesylate].
abstract: A 58-year-old man was admitted because of perforation of the small intestine by a gastrointestinal stromal tumor (GIST). First, the small intestine including a GIST was resected; and then 2 month later, a part of the liver (S5) conforming to metastatic lesion was surgically removed. Twelve months later, another liver metastases was found, and surgical treatment was recommended; but the patient requested non-surgical therapy, so a radiofrequency ablation (RFA) was successfully performed. After that, recurrence of liver metastasis was not observed, but another metastasis was observed on the fifth lumbar vertebra; so administration of imatinib mesylate was started. 28 months after the initial administration the metastatic liver lesion was still invisible, and the bone metastatic lesion had not grown. The patient is alive with good performance status. This report shows that multi-modality therapy by surgery, RFA and imatinib mesylate was effective for liver and bone metastases of GIST.
authors.affiliation: Department of Gastroenterology, Hitachi General Hospital.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Ishikawa
authors.forename: Takuma
authors.initials: T
authors.lastname: Teratani
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ono
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ochiai
authors.forename: Nobushige
authors.initials: N
authors.lastname: Kakinoki
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Toshirou
authors.initials: T
authors.lastname: Kamoshida
authors.forename: Shinji
authors.initials: S
authors.lastname: Hirai
authors.forename: Yuji
authors.initials: Y
authors.lastname: Oka
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Shimokama
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy*; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D007421:Intestine, Small; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate