title: Isokibdelones: novel heterocyclic polyketides from a Kibdelosporangium sp.
abstract: [Structure: see text] The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare actinomycete, Kibdelosporangium sp. The structures of the isokibdelones were assigned by spectroscopic analysis and chemical interconversion. A proposed biosynthesis requires a novel molecular twist that generates an unprecedented heterocyclic system and differentiates the isokibdelones from their kibdelone co-metabolites. SAR analysis on the isokibdelones further defines the anticancer pharmacophore of these novel polyketides.
authors.affiliation: Centre for Molecular Biodiversity, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.
authors.forename: Ranjala
authors.initials: R
authors.lastname: Ratnayake
authors.forename: Ernest
authors.initials: E
authors.lastname: Lacey
authors.forename: Shaun
authors.initials: S
authors.lastname: Tennant
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Gill
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Capon
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D018942:Macrolides