title: Monozygotic twins with Turner syndrome develop slipped capital femoral epiphysis on growth hormone therapy.
abstract: Monozygotic twins with Turner syndrome have rarely been reported. An increased incidence of slipped capital femoral epiphysis has been associated with growth hormone therapy, as well as with Turner syndrome, but has never been described in twins with Turner syndrome. We report the first case of monozygotic twins with Turner syndrome with a 46,Xi(Xq) karyotype, both of whom developed slipped capital femoral epiphysis during growth hormone therapy. This report adds to existing reports of monozygotic twins with Turner syndrome and contributes to recognition of the potential clinical course in such patients. In addition, the association between slipped capital femoral epiphysis, growth hormone therapy, and Turner syndrome is emphasized.
authors.affiliation: Section of Pediatric Endocrinology, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. znabhan@iupui.edu
authors.forename: Zeina M
authors.initials: ZM
authors.lastname: Nabhan
authors.forename: Erica A
authors.initials: EA
authors.lastname: Eugster
mesh_terms: D000293:Adolescent; D004839:Epiphyses, Slipped / Q000139:chemically induced*; D005260:Female; D005269:Femur; D013006:Growth Hormone / Q000009:adverse effects*; D006801:Humans; D010641:Phenotype; D014424:Turner Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000235:genetics; D014430:Twins, Monozygotic
chemical_list: D013006:Growth Hormone