title: Correlation between fibrinogen level and cerebral infarction.
abstract: OBJECTIVE
  To investigate the correlation between plasma fibrinogen level and cerebral infarction (CI) as well as the difference of fibrinogen among subtypes of CI.
  
  
  METHODS
  A case-controlled study was conducted with 131 cases of CI and 148 controls. Plasma fibrinogen levels were detected by the Clauss method.
  
  
  RESULTS
  High fibrinogen level (3.09 +/- 0.94 g/L) was correlated with CI (OR = 2.47, 95% CI: 1.51-4.04, P < 0.005) at the onset stage of the disease. Persistent high fibrinogen level (3.14 +/- 0.81 g/L) at 6-month after stroke onset was detected and correlated with CI (OR = 4.34, 95% CI: 1.80-10.51, P = 0.001). Higher fibrinogen level was correlated with total anterior circulation infarction (TACI), partial anterior circulation infarction (PACI), and posterior circulation infarction (POCI) (OR = 4.008, P < 0.001). Higher fibrinogen level was correlated with extracranial atherosclerosis (OR = 3.220, P < 0.05, but not with intracranial atherosclerosis.
  
  
  CONCLUSIONS
  Fibrinogen level may be a risk factor of CI and probably correlates with subtypes of CI and distributions of atherosclerosis.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730. zhuych910@yahoo.com.cn
authors.forename: Yi-cheng
authors.initials: YC
authors.lastname: Zhu
authors.forename: Li-ying
authors.initials: LY
authors.lastname: Cui
authors.forename: Bao-lai
authors.initials: BL
authors.lastname: Hua
authors.forename: Jia-qi
authors.initials: JQ
authors.lastname: Pan
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood*; D020520:Brain Infarction / Q000097:blood* / Q000145:classification*; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood / Q000145:classification; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D020243:Infarction, Anterior Cerebral Artery / Q000097:blood; D020762:Infarction, Posterior Cerebral Artery / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D005340:Fibrinogen