title: Testosterone replacement increases vasodilatory reserve in androgen-deficient female rats.
abstract: Testosterone replacement leads to increased coronary pressure-induced tone and vasodilatory reserve in oophorectomized rats. The mechanisms involve changes in endothelial nitric-oxide modulation of smooth-muscle constriction and are not a result of the peripheral conversion of T to estrogen.
authors.affiliation: Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, Vermont, USA. brian-cooper3825@hotmail.com <brian-cooper3825@hotmail.com>
authors.forename: Brian C
authors.initials: BC
authors.lastname: Cooper
authors.forename: Natalia I
authors.initials: NI
authors.lastname: Gokina
authors.forename: George
authors.initials: G
authors.lastname: Osol
mesh_terms: D000728:Androgens / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000008:administration & dosage*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
chemical_list: D000728:Androgens; D013739:Testosterone