title: Kleine-Levin syndrome in a 14-year-old girl: CSF hypocretin-1 measurements.
abstract: CSF hypocretin-1 measurements were performed during a period of hypersomnia and during an asymptomatic interval in a 14-year-old girl affected with severe Kleine-Levin syndrome. A twofold decrease in hypocretin-1 was evidenced during the period of hypersomnia in comparison with the asymptomatic interval. Together with previous data, this result is in favour of recurrent dysfunction at the hypothalamic level in Kleine-Levin syndrome.
authors.affiliation: Department of Neurology FLENI, Sleep Laboratory, Buenos-Aires, Argentina. cpodesta@fleni.org.ar
authors.forename: Claudio
authors.initials: C
authors.lastname: Podestá
authors.forename: Mónica
authors.initials: M
authors.lastname: Ferreras
authors.forename: Marcela
authors.initials: M
authors.lastname: Mozzi
authors.forename: Claudio
authors.initials: C
authors.lastname: Bassetti
authors.forename: Yves
authors.initials: Y
authors.lastname: Dauvilliers
authors.forename: Michel
authors.initials: M
authors.lastname: Billiard
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D017593:Kleine-Levin Syndrome / Q000134:cerebrospinal fluid*; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins
chemical_list: C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins