title: Oxidative amide synthesis and N-terminal alpha-amino group ligation of peptides in aqueous medium.
abstract: A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal alpha-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Wing-Kei
authors.initials: WK
authors.lastname: Chan
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Ho
authors.forename: Man-Kin
authors.initials: MK
authors.lastname: Wong
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D010084:Oxidation-Reduction; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D010455:Peptides; D014867:Water