Function of an N-heterocyclic carbene ligand based on concept of chiral mimetic.
Function of a new N-heterocyclic carbene ligand based on the concept of a chiral mimetic is described. With (4R,5R)-4,5-diphenyl-1,3-dialkyl-4,5-dihydro-3H-imidazol-1-ium tetrafluoroborates as N-heterocyclic carbene precursors, Rh-catalyzed enantioselective arylation (up to 27% ee) of aromatic aldehydes with arylboronic acids and Pd-catalyzed enantioselective intramolecular alpha-arylation (up to 66% ee) of N-(2-bromoaryl)-N-alkyl-2-arylpropanamides are investigated.
Arao
Takafumi
T
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Sato
Kei
K
Kondo
Kazuhiro
K
Aoyama
Toyohiko
T
D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006838:Hydrocarbons / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D018716:Molecular Mimicry; D013237:Stereoisomerism
D006571:Heterocyclic Compounds; D006838:Hydrocarbons; D008024:Ligands; C030011:carbene; D008697:Methane