Tissue reaction to poly (lactic-co-glycolic acid) copolymer membrane in rhBMP used rabbit experimental mandibular reconstruction.
A rabbit experimental mandibular defect was reconstructed with 1% atelocollagen gel including rhBMP-2 10microg and a covering a poly (lactic-co-glycolic acid) copolymer (PLGA) membrane. For this experiment, eight male rabbits were used and a histological study was conducted. Our study purpose was to examine the effects and fate of PLGA membrane during bone reconstruction. PLGA membrane was phagocytized by foreign body giant cells and macrophages in the healing course of reconstruction osteogenesis. These histological data suggest that the PLGA membrane was gradually absorbed and replaced by fibrous connective tissue or bone tissue. In the osteogenesis course, the outer periphery of the new bone was maintained by PLGA membrane without expansion.
Okafuji
Norimasa
N
Department of Orthodontics, Matsumoto Dental University School of Dentistry, 1780 Hirooka-Gobara, Shiojiri, 399-0781 Japan. okafuji@po.mdu.ac.jp
Shimizu
T
T
Watanabe
T
T
Kimura
A
A
Kurihara
S
S
Furusawa
K
K
Hasegawa
H
H
Kawakami
T
T
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D018786:Bone Substitutes / Q000737:chemistry; D016503:Drug Delivery Systems; D005782:Gels; D020007:Implants, Experimental; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D008334:Mandible / Q000378:metabolism / Q000601:surgery*; D008567:Membranes, Artificial; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D019651:Plastic Surgery Procedures; D023822:Tissue Engineering; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000494:pharmacology*
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D005782:Gels; D008567:Membranes, Artificial; D011108:Polymers; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid