Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia.
A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role for S. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.
Bubeck Wardenburg
Juliane
J
Department of Microbiology, University of Chicago, 920 E. 58th St., Chicago, IL 60637, USA.
Patel
Ravi J
RJ
Schneewind
Olaf
O
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D005098:Exotoxins / Q000235:genetics / Q000502:physiology*; D006651:Histocytochemistry; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011023:Pneumonia, Staphylococcal / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000235:genetics / Q000472:pathogenicity*; D016019:Survival Analysis
D001426:Bacterial Proteins; D005098:Exotoxins; D008565:Membrane Proteins