title: Initiated chemical vapor deposition of antimicrobial polymer coatings.
abstract: The vapor phase deposition of polymeric antimicrobial coatings is reported. Initiated chemical vapor deposition (iCVD), a solventless low-temperature process, is used to form thin films of polymers on fragile substrates. For this work, finished nylon fabric is coated by iCVD with no affect on the color or feel of the fabric. Infrared characterization confirms the polymer structure. Coatings of poly(dimethylaminomethyl styrene) of up to 540 microg/cm2 were deposited on the fabric. The antimicrobial properties were tested using standard method ASTM E2149-01. A coating of 40 microg/cm2 of fabric was found to be very effective against gram-negative Escherichia coli, with over a 99.99%, or 4 log, kill in just 2 min continuing to over a 99.9999%, or 6 log, reduction in viable bacteria in 60 min. A coating of 120 microg/cm2 was most effective against the gram-positive Bacillus subtilis. Further tests confirmed that the iCVD polymer did not leach off the fabric.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, MA, USA.
authors.forename: T P
authors.initials: TP
authors.lastname: Martin
authors.forename: S E
authors.initials: SE
authors.lastname: Kooi
authors.forename: S H
authors.initials: SH
authors.lastname: Chang
authors.forename: K L
authors.initials: KL
authors.lastname: Sedransk
authors.forename: K K
authors.initials: KK
authors.lastname: Gleason
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D011232:Chemical Precipitation; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D004926:Escherichia coli / Q000187:drug effects*; D005740:Gases / Q000737:chemistry; D008422:Materials Testing; D009757:Nylons / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D005740:Gases; D009757:Nylons; D011108:Polymers