title: Large size, villous content and distal location are associated with severe dysplasia in colorectal adenomas.
abstract: Adenomatous polyps are precursor lesions for colorectal carcinoma. The risk of cancer development has been associated with age and size, amount of villous component and high-grade dysplasia of adenomas. The subject-related and adenoma-related risk factors for severely dysplastic lesions were further investigated.
  
  
  METHODS
  The study was performed in 474 men and 339 women undergoing endoscopic removal at index colonoscopy of 1217 polyps.
  
  
  RESULTS
  The male gender, cases aged over 55 and cases examined for rectal bleeding, showed an increased risk of colorectal polyps (odds ratios, OR = 1.95, 5.1 and 2.99, respectively). Adenomas synchronous with hyperplastic polyps of larger diameter (>10 mm) showed an increased risk of severe dysplasia (OR = 6.94). Severe dysplasia occurred more significantly in younger subjects harbouring villous growths (OR = 4.28, p < 0.03) and in larger adenomas (OR = 3.91, p < 0.001). The risk for severe dysplasia in relation to gender, age, multiplicity and location was higher in adenomas of larger diameter and with villous content. Multivariate analysis showed that distal site (p < 0.02), large size (p < 0.001) and villous content (p < 0.001) were the independent risk factors for severe dysplasia.
  
  
  CONCLUSIONS
  Large size, villous content and distal location are associated with severe dysplasia in colorectal adenomas. The risk for severe dysplasia does not appear to be correlated with age.
authors.affiliation: Department of Surgery Pietro Valdoni, University La Sapienza, Policlinico Umberto I, viale Policlinico 155, 00161 Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Giuliani
authors.forename: Alessandro
authors.initials: A
authors.lastname: Caporale
authors.forename: Mario
authors.initials: M
authors.lastname: Corona
authors.forename: Teresa
authors.initials: T
authors.lastname: Ricciardulli
authors.forename: Marco
authors.initials: M
authors.lastname: Di Bari
authors.forename: Martino
authors.initials: M
authors.lastname: Demoro
authors.forename: Massimo
authors.initials: M
authors.lastname: Scarpini
authors.forename: Francesco
authors.initials: F
authors.lastname: Angelico
mesh_terms: D000236:Adenoma / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D012372:ROC Curve; D012307:Risk Factors