Fertility in men with Down syndrome: a case report.
OBJECTIVE
To inform clinicians about fertility in males with Down syndrome.


METHODS
Case report.


METHODS
Medical Genetics Department of a tertiary-care hospital.


METHODS
A 26-year-old man with confirmed nonmosaic trisomy 21.


METHODS
Karyotype, amniocentesis, paternity testing using microsatellite markers.


METHODS
Confirmed paternity in the son of a male with nonmosaic trisomy 21.


RESULTS
A male with nonmosaic Down syndrome fathered a normal son, and the paternity was proven by microsatellite marker analysis.


CONCLUSIONS
Although Down syndrome males have been reported to be infertile, it may not always be true. Infertility in males has been attributed to defective spermatogenesis, but ignorance of the sexual act may be one of the contributing factors. It is important to advise postpubertal Down syndrome males on contraceptive measures.
Pradhan
Mandakini
M
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. mandakini@sgpgi.ac.in <mandakini@sgpgi.ac.in>
Dalal
Ashwin
A
Khan
Faisal
F
Agrawal
Suraksha
S
D000328:Adult; D004314:Down Syndrome; D005298:Fertility; D006801:Humans; D008297:Male