title: The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies.
abstract: There is increasing evidence for epistatic interactions between gene products (e.g. KIR) encoded within the Leukocyte Receptor Complex (LRC) with those (e.g. HLA) of the Major Histocompatibility Complex (MHC), resulting in susceptibility to disease. Identification of such associations at the DNA level requires comprehensive knowledge of the genetic variation and haplotype structure of the underlying loci. The LRC haplotype project aims to provide this knowledge by sequencing common LRC haplotypes.
authors.affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: R
authors.initials: R
authors.lastname: Horton
authors.forename: P
authors.initials: P
authors.lastname: Coggill
authors.forename: M M
authors.initials: MM
authors.lastname: Miretti
authors.forename: J G
authors.initials: JG
authors.lastname: Sambrook
authors.forename: J A
authors.initials: JA
authors.lastname: Traherne
authors.forename: R
authors.initials: R
authors.lastname: Ward
authors.forename: S
authors.initials: S
authors.lastname: Sims
authors.forename: S
authors.initials: S
authors.lastname: Palmer
authors.forename: H
authors.initials: H
authors.lastname: Sehra
authors.forename: J
authors.initials: J
authors.lastname: Harrow
authors.forename: J
authors.initials: J
authors.lastname: Rogers
authors.forename: M
authors.initials: M
authors.lastname: Carrington
authors.forename: J
authors.initials: J
authors.lastname: Trowsdale
authors.forename: S
authors.initials: S
authors.lastname: Beck
mesh_terms: D002874:Chromosome Mapping; D030541:Databases, Genetic; D036281:Genetic Research; D014644:Genetic Variation; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D020407:Internet; D011971:Receptors, Immunologic / Q000145:classification* / Q000235:genetics*; D054340:Receptors, KIR
chemical_list: D011971:Receptors, Immunologic; D054340:Receptors, KIR