Role of DJ-1 in Parkinson's disease.
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is a multifactorial disease caused by both genetic and environmental factors. Although most patients suffering from PD have a sporadic disease, several genetic causes have been identified in recent years, including alpha-synuclein, parkin, PINK1, dardarin (LRRK2), and DJ-1. DJ-1 deletions and point mutations have been found worldwide, and loss of functional protein was shown to cause autosomal recessive PD. Moreover, DJ-1 immunoreactive inclusions are found in other alpha-synucleopathies and tauopathies, indicating that different neurodegenerative diseases might share a common mechanism in which DJ-1 might play a key role. The function of DJ-1 is still unknown; however, it is associated with various cellular processes, including response to oxidative stress, cellular transformation, RNAbinding, androgen-receptor signaling, spermatogenesis, and fertilization. This article reviews the current knowledge on DJ-1, focusing on its importance in the pathogenesis of PD.
Lev
Nirit
N
Laboratory of Neuroscience, Department of Neurology, FMRC, Rabin Medical Center, Tel Aviv University, Israel. lev.nirit@gmail.com
Roncevic
Dusan
D
Roncevich
Dusan
D
Ickowicz
Debby
D
Melamed
Eldad
E
Offen
Daniel
D
D000818:Animals; D002472:Cell Transformation, Viral / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D029721:Drosophila Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics; D005808:Genes, Recessive; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009410:Nerve Degeneration / Q000235:genetics / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D015513:Oncogene Proteins / Q000032:analysis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology; D020734:Parkinsonian Disorders / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D054464:Peroxiredoxins; D000071617:Protein Deglycase DJ-1; D024801:Tauopathies / Q000235:genetics / Q000503:physiopathology; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000502:physiology; D051844:alpha-Synuclein / Q000235:genetics / Q000502:physiology
C506878:DJ-1alpha protein, Drosophila; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D015513:Oncogene Proteins; D051844:alpha-Synuclein; D054464:Peroxiredoxins; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; C506879:DJ-1beta protein, Drosophila; C105131:PARK7 protein, human; C503466:PARK7 protein, mouse; D000071617:Protein Deglycase DJ-1; D004298:Dopamine