Clofazimine induced enteropathy--a case highlighting the importance of drug induced disease in differential diagnosis.
A patient on treatment for multibacillary leprosy for the past three years, presented with episodes of abdominal pain. Since the patient improved with conservative management, clofazimine induced enteropathy was considered as a remote possibility. A review of the mucosal biopsies showed macrophages with crystal-storing spaces consistent with clofazimine deposition in the duodenum. This case highlights the need to consider and investigate drug-induced disease as part of the differential diagnosis.
Mathew
Binu S
BS
Department of Pharmacology and Clinical Pharmacology, Christian Medical College Hospital, Vellore 632004, Tamil Nadu, India. clinpharm@cmcvellore.ac.in
Pulimood
Anna B
AB
Prasanna
C G
CG
Ramakrishna
B S
BS
Chandy
Sujith J
SJ
D002991:Clofazimine / Q000009:adverse effects*; D004378:Duodenal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005757:Gastritis, Atrophic / Q000139:chemically induced; D006801:Humans; D007917:Leprostatic Agents / Q000009:adverse effects*; D015440:Leprosy, Lepromatous / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D007917:Leprostatic Agents; D002991:Clofazimine