title: Postnatal development and reproductive performance of F1 progeny exposed in utero to an ayurvedic contraceptive: Pippaliyadi yoga.
abstract: Pippaliyadi yoga or pippaliyadi vati is an ayurvedic contraceptive used in India since ancient times. It is a combination of powdered fruit berries of Embelia ribes Burm.f. (Myrsinaceae), Piper longum L. (Piperaceae) and borax in equal proportion. Though the contraceptive potential is known since ancient times, no systematic developmental toxicity studies have been carried out. The present study was carried out to evaluate the postnatal developmental toxicity and the reproductive performance of the progeny exposed in utero to pippaliyadi. Pippaliyadi yoga was obtained from National Institute for Pharmaceutical Education and Research (NIPER), India and the developmental toxicity was studied by administering three doses, viz. 140, 300 and 700 mg/(kg day) to gravid females from day 6 to day 16 of gestation. Pippaliyadi did not have any adverse developmental effects with low doses, however, with the five times higher dose, a decrease in body weight of the pups was observed. The reproductive performance of the progeny born to mothers treated with pippaliyadi was not significantly affected. The present study suggests that in utero exposure to pippaliyadi does not have any adverse effect on the postnatal development and reproductive performance of the F(1) progeny.
authors.affiliation: National Institute for Research in Reproductive Health (ICMR), J.M. Street, Parel, Mumbai 400012, Maharashtra, India. nafisbala@hotmail.com
authors.forename: Nafisa
authors.initials: N
authors.lastname: Balasinor
authors.forename: Ashima
authors.initials: A
authors.lastname: Bhan
authors.forename: Niraja S
authors.initials: NS
authors.lastname: Paradkar
authors.forename: Arifa
authors.initials: A
authors.lastname: Shaikh
authors.forename: Tarala D
authors.initials: TD
authors.lastname: Nandedkar
authors.forename: K K
authors.initials: KK
authors.lastname: Bhutani
authors.forename: Mandakini
authors.initials: M
authors.lastname: Roy-Chaudhury
mesh_terms: D000818:Animals; D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D031645:Embelia; D005260:Female; D005638:Fruit / Q000737:chemistry; D006197:Hair / Q000187:drug effects / Q000254:growth & development; D008297:Male; D008431:Maternal-Fetal Exchange; D008515:Medicine, Ayurvedic; D031701:Piper; D028321:Plant Preparations / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects; D014621:Vagina / Q000187:drug effects / Q000254:growth & development
chemical_list: D003271:Contraceptive Agents, Female; D028321:Plant Preparations