Spontaneous otitis media in Wistar rats: an overlooked pathology in otological research.
The rat is commonly employed in otological research, but spontaneous ear infections can confound the results of experimental procedures--wasting time, money, and animals. The authors focus on the incidence of spontaneous otitis media in Wistar rats. They compare disease incidence in animals housed in standard cages with those housed in barrier units, showing that 20% of their conventionally housed animals developed spontaneous otitis media, whereas only 5% of their animals housed in isolated units were infected. These results underscore the importance of strict control of the shipping, housing conditions, and manipulation of animals to be used in otological research.
Verdaguer
José María
JM
Department of Otorhinolaryngology, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Spain. josem.verdaguer@gmail.com
Trinidad
Almudena
A
González-García
José Angel
JA
García-Berrocal
José Ramón
JR
Ramírez-Camacho
Rafael
R
D000822:Animal Husbandry / Q000379:methods*; D000818:Animals; D000830:Animals, Laboratory; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005072:Evoked Potentials, Auditory; D005260:Female; D015994:Incidence; D010034:Otitis Media with Effusion / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D051381:Rats; D017208:Rats, Wistar; D012376:Rodent Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology*