[The evaluation of bioavailability and pharmacokinetic parameters of a new antimicrobial preparation trichomikocid].
Antimicrobial preparations are not effective enough for the normalisation of vaginal microflora, regeneration of it's mucosal layer and thus there are still conditions Amaintained for recidives or reinfection of the disease. In addition, there is a limited arsenal of combinations of trichomikocidal preparations. It is very important problem of modern medicine and pharmacology to create new drugs, especially of natural origin, to treat urogenital trichomonias and trichomona-fungal infections. The purpose of the trial was to study biopenetration and pharmacokinetic parameters of preparation trichomikocid suppositories for vaginal and rectal use. In vitro and in vivo investigations have shown that the level of biological penetration is higher during the use of trichomikocid suppositories for vaginal and rectal use (95% and 96%) than during the oral use (75%). Correlations between the data of in vivo and in vitro investigations has been found.
Eriashvili
T V
TV
Kintraia
N P
NP
Dugashvili
N G
NG
D000818:Animals; D000994:Antitrichomonal Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001682:Biological Availability; D004333:Drug Administration Routes; D005260:Female; D011817:Rabbits; D013997:Time Factors; D014245:Trichomonas Infections / Q000188:drug therapy*
D000994:Antitrichomonal Agents