title: Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes.
abstract: We demonstrate here that the Epstein-Barr virus (EBV) BZLF1 gene, a switch from latent infection to lytic infection, is expressed as early as 1.5 h after EBV infection in Burkitt's lymphoma-derived, EBV-negative Akata and Daudi cells and primary B lymphocytes. Since BZLF1 mRNA is expressed even when the cells are infected with EBV in the presence of anisomycin, an inhibitor of protein synthesis, its expression does not require prerequisite protein synthesis, indicating that BZLF1 is expressed as an immediate-early gene following primary EBV infection of B lymphocytes.
authors.affiliation: Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.
authors.forename: Wangrong
authors.initials: W
authors.lastname: Wen
authors.forename: Dai
authors.initials: D
authors.lastname: Iwakiri
authors.forename: Koji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Maruo
authors.forename: Teru
authors.initials: T
authors.lastname: Kanda
authors.forename: Kenzo
authors.initials: K
authors.lastname: Takada
mesh_terms: D001402:B-Lymphocytes / Q000821:virology*; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D020031:Epstein-Barr Virus Infections / Q000821:virology; D017781:Genes, Immediate-Early; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism; D017735:Virus Latency
chemical_list: C063676:BZLF1 protein, Herpesvirus 4, Human; D004268:DNA-Binding Proteins; D015534:Trans-Activators; D014764:Viral Proteins