[Amiodaron effects on atrioventricular conduction].
OBJECTIVE
To assess short- and long-term effects of amiodaron on atrioventricular conduction (AVC) of the heart.


METHODS
Amiodaron was given to 477 patients (mean age 48.7 +/- 0.7 years) with various arrhythmias caused, as a rule by coronary heart disease. A mean saturation dose was 809.4 +/- 13.4 mg/day, a mean maintanence dose--263.5 +/- 5.4 mg/day. Mean follow-up 20.85 +/- 1.2 months. The frequency of AVC disorders was estimated at regular Holter monitoring.


RESULTS
In saturation, atrioventricular block of the first degree arose in 17.2% patients, of the second and third degree--only in one patient. AVC disorders disappeared at reduction of amiodaron dose. Only in one patient the drug was discontinued because of recurrent block of the third degree and bradycardia.


CONCLUSIONS
In saturation, ECG records lengthening of P-R intervals by 18.9%, on the average. Maintenance therapy increases the length of P-R interval by 8.1%, on the average.
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D000638:Amiodarone / Q000008:administration & dosage / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002036:Bundle of His / Q000187:drug effects* / Q000503:physiopathology; D003327:Coronary Disease / Q000150:complications; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone