[Cyto- and histological criteria for a risk of environment-induced diseases].
The author proposes morphological criteria determining the risk of environment-induced diseases. The experimental studies analyzing 23 indices of the development of reparative regeneration in the liver of rats exposed to environmental factors have revealed that a significant change in the ratio of uni- and binuclear tetraploid hepatocytes is a criterion for the risk of hepatotoxic effect. Evaluation of the cytological status of nasal and oral mucosae, by using 21 indices has indicated that a significant reduction in the proportion of individuals with the normal cytological status is a criterion for the risk of environment-induced diseases.
Beliaeva
N N
NN
D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects*; D018876:Environmental Illness / Q000209:etiology / Q000473:pathology*; D006801:Humans; D012307:Risk Factors