Is remission in rheumatoid arthritis associated with radiographic healing?
The precondition for joint damage in rheumatoid arthritis (RA) is inflammation, and the precondition for healing is absence of inflammation. A systematic search for healing phenomena in RA patients in remission has not yet been undertaken. In reports of patients in whom healing was observed, clinical and laboratory data have not been published in part due to space restrictions. However, this preliminary review of the existing literature about repair supports the thesis that a strong association may exist between remission and repair. Several reports indicate that patients in whom radiographic repair was seen were in clinical remission. In most reports clinical response to treatment was very good, and in groups of patients in which scoring was done, evidence of repair was seen in patients with strong inhibition or halt of radiographic progression. In contrast, healing is unlikely to be detected in patients with persistent clinically active disease and/or moderate or strong radiographic progression. In most reports clinical response to treatment was very good, and in groups of patients in which scoring was done, evidence of repair was seen in patients with strong inhibition or halt of radiographic progression. In contrast, healing is unlikely to be detected in patients with persistent clinically active disease and/or moderate or strong radiographic progression.
Rau
R
R
Department of Rheumatology, Evangel- isches Fachkrankenhaus Ratingen, Ratingen, Germany. Rau.Herborn@t-online.de
D001172:Arthritis, Rheumatoid / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D001175:Arthrography; D002986:Clinical Trials as Topic; D018450:Disease Progression; D023381:Endpoint Determination; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D020127:Recovery of Function; D012074:Remission Induction; D012720:Severity of Illness Index