Blood glucose-lowering activity of colestimide in patients with type 2 diabetes and hypercholesterolemia: a case-control study comparing colestimide with acarbose.
BACKGROUND
An anion exchange resin has been reported to lower blood glucose levels in patients with type 2 diabetes.


OBJECTIVE
To examine, in comparison with an alpha-glucosidase inhibitor, the usefulness of colestimide in lowering blood glucose levels in patients with type 2 diabetes and hypercholesterolemia.


METHODS
Thirty-three patients with type 2 diabetes and hypercholesterolemia were more or less randomly assigned to receive either colestimide (17 patients) or acarbose (16 patients). At 10 time points before and after administration, plasma glucose levels and serum lipid concentrations were measured in all subjects, and the J-index and M-value were calculated.


RESULTS
Patients receiving colestimide showed significant decreases in glucose levels 2 hours after breakfast (from 216.9 +/- 37.2 mg/dl before treatment to 191.1 +/- 40.9 mg/dl after treatment; p=0.008), in the J-index (from 42.6 +/- 14.5 to 32.6 +/- 9.8; p<0.001), and in the M-value (from 23.1 +/- 12.1 to 14.6 +/- 7.1; p<0.001).


CONCLUSIONS
In patients with type 2 diabetes and hyperlipidemia, colestimide was suggested to have blood glucose-lowering activity as does acarbose.
Suzuki
Tatsuya
T
Department of Functional Pathophysiology for Human Organs, Nippon Medical School Graduate School of Medicine, Tokyo, Japan. t-suzuki@nms.ac.jp
Oba
Kenzo
K
Futami
Shoko
S
Suzuki
Kazunari
K
Ouchi
Motoshi
M
Igari
Yoshimasa
Y
Matsumura
Noriaki
N
Watanabe
Kentaro
K
Kigawa
Yoshiaki
Y
Nakano
Hiroshi
H
D020909:Acarbose / Q000627:therapeutic use*; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004811:Epichlorohydrin / Q000627:therapeutic use*; D005260:Female; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007093:Imidazoles / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D012117:Resins, Synthetic / Q000627:therapeutic use*
D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007093:Imidazoles; D008055:Lipids; D012117:Resins, Synthetic; C417427:colestimide; D004811:Epichlorohydrin; D020909:Acarbose