title: Role of DHEA and growth factors in chromaffin cell proliferation.
abstract: Dehydroepiandrostreone (DHEA) is a neuroactive steroid produced by the inner layer of the adrenal cortex close to the adrenomedullary cells. Chromaffin cell growth and proliferation are under the control of insulin-like growth factor II (IGF-II) and basic fibroblast growth factor (bFGF). The aim of the present study was to examine the role of DHEA on chromaffin cell proliferation induced by IGF-II and bFGF. In our model, DHEA significantly decreased IGF-II-induced proliferation by 48.7%, whereas it did not affect the proliferation induced by bFGF. These data suggest that DHEA exerts a paracrine function in the control of chromaffin cell growth.
authors.affiliation: Department of Medicine, Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Sicard
authors.forename: A W
authors.initials: AW
authors.lastname: Krug
authors.forename: C G
authors.initials: CG
authors.lastname: Ziegler
authors.forename: S
authors.initials: S
authors.lastname: Sperber
authors.forename: M
authors.initials: M
authors.lastname: Ehrhart-Bornstein
authors.forename: S R
authors.initials: SR
authors.lastname: Bornstein
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D019439:Chromaffin Cells / Q000166:cytology / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000494:pharmacology*
chemical_list: D016222:Fibroblast Growth Factor 2; D003687:Dehydroepiandrosterone; D007335:Insulin-Like Growth Factor II