[The VDAC channel as the mitochondria function regulator].
Regulation of mitochondria physiology, indispensable for proper cell activity, requires an efficient exchange of molecules between mitochondria and cytoplasm at the level of the mitochondrial outer membrane. The common pathway for the metabolite exchange between mitochondria and cytoplasm is the VDAC channel (voltage dependent anion channel), known also as mitochondrial porin. The channel was identified for the first time in 1976 and since that time has been extensively studied. It has been recognized that the VDAC channel plays a crucial role in the regulation of metabolic and energetic functions of mitochondria. In this article we review the VDAC channel relevance to ATP rationing, Ca2+ homeostasis, protection against oxidative stress and apoptosis execution.
Kmita
Hanna
H
Zakład Bioenergetyki, Instytut Biologii Molekularnej i Biotechnologii, Uniwersytet im. Adama Mickiewicza, ul. Fredry 10, 61-701 Poznań kmita@amu.edu.pl
Stobienia
Olgierd
O
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D003574:Cytochrome c Group / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D051336:Mitochondrial Membranes / Q000378:metabolism; D008958:Models, Molecular; D010539:Permeability; D018272:Porins / Q000378:metabolism; D050994:Voltage-Dependent Anion Channels / Q000378:metabolism*
D003574:Cytochrome c Group; D018272:Porins; D050994:Voltage-Dependent Anion Channels; D000255:Adenosine Triphosphate; D002118:Calcium