Pregnancy complications and delivery outcomes in pregnant women with severe migraine.
OBJECTIVE
The objective was to study the possible association among maternal migraine during pregnancy, pregnancy complications, and the delivery outcomes: sex ratio, gestational age/birth weight and preterm birth/low birth weight.


METHODS
The population-based large data set of newborn infants without any defects of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996 was analyzed.


RESULTS
Out of 38,151 newborn infants, 713 (1.9%) had mothers who had severe migraine during pregnancy; 68% were medically recorded. Pregnant women with severe migraine had a higher prevalence of preeclampsia and severe nausea/vomiting, but a lower occurrence of threatened abortion and preterm delivery. However, mean gestational age and birth weight, as well as the proportion of low birth weight and preterm births, were similar in newborn infants born to mothers with or without migraine.


CONCLUSIONS
Severe maternal migraine and its related drug treatment may increase the occurrence of preeclampsia and severe nausea/vomiting during pregnancy, but is not associated with unfavorable delivery outcomes.
Bánhidy
Ferenc
F
Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary.
Acs
Nándor
N
Horváth-Puhó
Erzsébet
E
Czeizel
Andrew E
AE
D001719:Birth Certificates; D016022:Case-Control Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D006814:Hungary; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008881:Migraine Disorders / Q000150:complications* / Q000188:drug therapy; D048968:Morning Sickness; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth; D012189:Retrospective Studies