Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima.
Three new natural sesquiterpene coumarins, isofeterin (1), lehmannolol (3), sinkianone (4), and one known compound, lehmannolone (2), were isolated from the roots of Ferula teterrima and Ferula sinkiangensis. Their chemical structures were established on the basis of spectroscopic analysis, including X-ray crystallography and CD spectrum measurements for determining the absolute configuration of compound 2.
Yang
Jun-Rong
JR
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Beijing, PR China.
An
Zheng
Z
Li
Zhi-Hong
ZH
Jing
Song
S
Qina
Hai-Lin
HL
D002942:Circular Dichroism; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D005309:Ferula / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D013045:Species Specificity; D013237:Stereoisomerism
D003374:Coumarins; D012717:Sesquiterpenes; C516732:isofeterin; C516733:lehmannolol; C516734:sinkianone