Medicated intrauterine systems for treatment of endometriosis-associated pain.
Medicated intrauterine systems (IUSs) are intrauterine devices that act by means of the local release of a medication. The levonorgestrel (LNG)-IUS is a T-shaped device that releases the progestogen LNG directly into the uterine cavity. The LNG-IUS can be used with noncontraceptive, therapeutic intent for idiopathic menorrhagia, hormonal replacement therapy in conjunction with oral or transdermal estrogens, and endometriosis or adenomyosis-associated pain. For this last indication, however, the use of the LNG-IUS is still under clinical investigation.
Muzii
Ludovico
L
Department of Obstetrics and Gynecology, Campus Bio-Medico University, Rome, Italy. l.muzii@unicampus.it
D003271:Contraceptive Agents, Female / Q000008:administration & dosage; D016503:Drug Delivery Systems; D004715:Endometriosis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007434:Intrauterine Devices; D016912:Levonorgestrel / Q000008:administration & dosage; D008595:Menorrhagia / Q000188:drug therapy; D017699:Pelvic Pain / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control
D003271:Contraceptive Agents, Female; D016912:Levonorgestrel