title: Basal cell carcinoma metastatic to cervical lymph nodes and lungs.
abstract: Metastatic basal cell carcinoma (MBCC) of the skin is rare in occurrence and may initially elude proper diagnosis and management. We describe a case of MBCC to cervical lymph nodes, originally evaluated and treated surgically as metastatic thyroid carcinoma. After definitive diagnosis of MBCC was made, chemotherapy and concomitant radiation treatment were initiated; however, despite these measures, the patient then developed MBCC to the lung. Risk factors and current therapeutic modalities for MBCC are also discussed. In addition to the more commonly metastasizing carcinomas, metastases from a cutaneous basal cell carcinoma primary tumor should be considered when evaluating cervical lymph node metastases of an uncertain head and neck primary.
authors.affiliation: Department of Internal Medicine, University of California San Francisco-Fresno, Fresno, CA, USA. jboswell@fresno.ucsf.edu
authors.forename: J Scott
authors.initials: JS
authors.lastname: Boswell
authors.forename: Marshall S
authors.initials: MS
authors.lastname: Flam
authors.forename: David N
authors.initials: DN
authors.lastname: Tashjian
authors.forename: Tai-Po
authors.initials: TP
authors.lastname: Tschang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D044963:Biopsy, Fine-Needle; D016190:Carboplatin / Q000008:administration & dosage; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D002291:Carcinoma, Papillary / Q000175:diagnosis*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D003951:Diagnostic Errors; D000077143:Docetaxel; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D016609:Neoplasms, Second Primary; D011878:Radiotherapy; D018239:Seminoma; D012878:Skin Neoplasms / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage; D013736:Testicular Neoplasms; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D013965:Thyroidectomy; D019564:Unnecessary Procedures; D000093542:Gemcitabine
chemical_list: D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D016190:Carboplatin; D000093542:Gemcitabine