title: Fabrication of biporous low-crystalline apatite based on mannitol dissolution from apatite cement.
abstract: Biporous (macro- and microporous) calcium phosphate gains much attention as a bone substitute material because of its large surface area and that it improves cell penetration. In the present study, we evaluated the feasibility of biporous, low-crystalline apatite based on dissolution of mannitol from self-setting apatite cement (Biopex). Mannitol--known as a biocompatible, easily dissolved monosaccharide alcohol--was recrystallized to obtain larger crystals. It was crushed with pestle and mortar, sieved to obtain crystals which passed through a 500-microm mesh but which remained against a 300-microm mesh, and then used as porogen. Although Biopex containing 60 wt% mannitol was not able to be taken out of the mold, addition of mannitol caused no initial setting inhibition to Biopex if the amount was 40 wt% or less. Similarly, transformation to apatitic product was confirmed when the apatite cement was immersed in 0.9% saline kept at 37 degrees C for seven days. The set mass became low-crystalline, biporous apatite with approximately 60% porosity.
authors.affiliation: Japan Institute for Advanced Dentistry, Tokyo.
authors.forename: Shinya
authors.initials: S
authors.lastname: Tajima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kishi
authors.forename: Makoto
authors.initials: M
authors.lastname: Oda
authors.forename: Michito
authors.initials: M
authors.lastname: Maruta
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsuya
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000648:ultrastructure; D005240:Feasibility Studies; D006882:Hydroxyapatites / Q000737:chemistry*; D008353:Mannitol / Q000737:chemistry / Q000494:pharmacology*; D013386:Succinates / Q000737:chemistry*
chemical_list: C481019:Biopex; D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; D013386:Succinates; D008353:Mannitol; D002809:Chondroitin Sulfates