1,1,1-tris(hydroxymethyl)ethane as a new, efficient, and versatile tripod ligand for copper-catalyzed cross-coupling reactions of aryl iodides with amides, thiols, and phenols.
1,1,1-tris(hydroxymethyl)ethane was presented as a new, efficient, and versatile tridentate O-donor ligand suitable for the copper-catalyzed formation of C-N, C-S, and C-O bonds. This inexpensive and commercially available tripod ligand has been demonstrated to facilitate the copper-catalyzed cross-coupling reactions of aryl iodides with amides, thiols, and phenols to afford the corresponding desired products in good to excellent yields. [reaction: see text].
Chen
Yao-Jung
YJ
Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan 402, ROC. yjchen@dragon.nchu.edu.tw
Chen
Hsin-Hung
HH
D000473:Alkanes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007202:Indicators and Reagents; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D010636:Phenols / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry
C522756:1,1,1-tris(hydroxymethyl)ethane; D000473:Alkanes; D000577:Amides; D007202:Indicators and Reagents; D007454:Iodides; D008024:Ligands; D010636:Phenols; D013438:Sulfhydryl Compounds; D003300:Copper