title: Total synthesis and stereochemistry of the antitumor antibiotic PD 113,271.
abstract: [Structure: see text] A total synthesis of PD 113,271, an antitumor fostriecin analogue isolated from Streptomyces pulveraceus, was achieved by the chiral pool approach starting with D-galactose and L-tartaric acid. The synthesis of PD 113,271 led to unambiguous assignment of the relative and absolute stereochemistry of its stereocenters.
authors.affiliation: Department of Applied Biological Science and Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI), 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Kouji
authors.initials: K
authors.lastname: Kuramochi
authors.forename: Susumu
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Fumio
authors.initials: F
authors.lastname: Sugawara
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; C040315:PD 113271