title: Incidence of de novo nonmelanoma skin tumors after liver transplantation for alcoholic and nonalcoholic liver diseases.
abstract: BACKGROUND
  Skin tumors are the most common malignancies after orthotopic liver transplantation (OLT). They have been related to sunlight exposure, tobacco consumption, and immunosuppression. The aim of this study was to compare the incidence of de novo skin tumors (nonmelanoma) in patients who underwent liver transplantation for alcoholic cirrhosis versus nonalcoholic diseases.
  
  
  METHODS
  Between April 1986 and July 2004, we performed 1000 OLT in a population of 888 recipients. This study was performed in a sample of 701 adult recipients who survived >2 months after transplantation: 276 patients (39.4%) underwent OLT for alcoholic cirrhosis (AC-group), and 425 (60.6%) for nonalcoholic disease (N-AC). The overall incidence of de novo skin tumors was 3.5% (25 tumors): 5.4% (15 tumors) in the AC-group and 2.4% (10 tumors) in the N-AC group (P = .027). Two patients developed two tumors. There were 19 men and 4 women, mean age at OLT of 54.4 +/- 6.8 years (range, 40 to 66 years). The mean time from OLT to tumor diagnosis was 66.1 +/- 51.4 months (range, 3 to 165 months): 56.4 +/- 44.4 months in the AC-group versus 80.6 +/- 59.8 months in the N-AC group (P = NS). Histologically, 17 tumors (68%) were basal cell carcinomas and eight tumors (32%) were squamous cell carcinomas (P = .128). Fourteen patients (60.8%) were smokers: 11 patients (84.6%) in the AC-group versus 3 patients (30%) in the N-AC group (P = .012). All the patients underwent tumor resection, with only one patient dying, because of lymph node invasion of the neck.
  
  
  CONCLUSIONS
  There was a higher incidence of de novo skin tumors among patients who smoked who underwent OLT for alcoholic cirrhosis.
authors.affiliation: Service of General Surgery, Hospital Doce de Octubre, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Jiménez-Romero
authors.forename: A
authors.initials: A
authors.lastname: Manrique Municio
authors.forename: E
authors.initials: E
authors.lastname: Marqués Medina
authors.forename: F
authors.initials: F
authors.lastname: Colina
authors.forename: P
authors.initials: P
authors.lastname: Ortega Domene
authors.forename: R
authors.initials: R
authors.lastname: Gómez Sanz
authors.forename: J C
authors.initials: JC
authors.lastname: Meneu Diaz
authors.forename: M
authors.initials: M
authors.lastname: Abradelo de Usera
authors.forename: A
authors.initials: A
authors.lastname: Moreno Elola
authors.forename: E
authors.initials: E
authors.lastname: Moreno Gonzalez
mesh_terms: D000328:Adult; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D008107:Liver Diseases / Q000145:classification / Q000601:surgery*; D008108:Liver Diseases, Alcoholic / Q000145:classification / Q000601:surgery*; D016031:Liver Transplantation / Q000276:immunology; D009369:Neoplasms / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000453:epidemiology*; D013472:Sunlight / Q000009:adverse effects
chemical_list: D007166:Immunosuppressive Agents