[Studies on the effect of extracts of several Chinese herbal medicines and other medicines on alcohol dehydrogenase activity].
OBJECTIVE
To study the effects of water and alcohol extracts of several Chinese herbal medicines and other medicines on alcohol dehydrogenase activity in order to provide enzymology basis on new medicine.


METHODS
Water or alcohol extracts of Chinese herbal medicine and other medicine were tested on the effects of alcohol dehydrogenase activity by Valle and Hoch method.


RESULTS
Among them, 8 were found to have the effect of activation on alcohol dehydrogenase. They were water extracts of Amomum kravanh and Pueraria flowers, the alcohol extracts of Pueraria flowers, compound hepatcare Chinese medicine and compound Pueraria medicine, L-cysteine, notoginseng saponin. Others had inhibiting action.


CONCLUSIONS
To decrease alcohol concentration in the body through activating the activity of ADH may be one of the mechanisms for some traditional Chinese herbal medicine in neutralizing the effect of alcohol drink.
Li
Wen-Zhe
WZ
College of Life Science and Technology of Tongji University, Shanghai 200092, China. lwz@mail.tongji.edu.cn
Lu
Jie
J
Sun
Xiao-Yu
XY
Wang
Shi-Long
SL
Ni
Ya-Ming
YM
Zhu
Wen-Si
WS
D000426:Alcohol Dehydrogenase / Q000187:drug effects / Q000378:metabolism*; D003545:Cysteine / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D000431:Ethanol / Q000097:blood* / Q000633:toxicity; D008099:Liver / Q000201:enzymology*; D010946:Plants, Medicinal / Q000737:chemistry*; D020011:Protective Agents / Q000494:pharmacology; D011899:Ranitidine / Q000494:pharmacology; D014867:Water
D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D014867:Water; D000431:Ethanol; D011899:Ranitidine; D000426:Alcohol Dehydrogenase; D003545:Cysteine