TLRS in the gut. II. Flagellin-induced inflammation and antiapoptosis.
Flagellin is bacterial protein that serves as a danger signal across a wide variety of eukaryotes and is a potent inducer of inflammatory effector responses in the mammalian gut. Recent findings utilizing purified flagellin and flagellate/aflagellate bacteria in in vitro and in vivo systems have revealed the important roles played by flagellin in the initial encounter between mucosa and flagellate bacteria, specifically in the modulation of apoptotic responses.
Neish
Andrew S
AS
Dept of Pathology, Emory Univ School of Medicine, Atlanta, GA 30322, USA. aneish@emory.edu
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D001424:Bacterial Infections / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D053468:CARD Signaling Adaptor Proteins / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology; D005408:Flagellin / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D007413:Intestinal Mucosa / Q000502:physiology; D008954:Models, Biological; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000502:physiology; D051198:Toll-Like Receptor 5 / Q000502:physiology; D051193:Toll-Like Receptors / Q000502:physiology*
D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D002135:Calcium-Binding Proteins; C512299:Ipaf protein, mouse; C435692:NLRC4 protein, human; C496806:Naip5 protein, mouse; D051616:Neuronal Apoptosis-Inhibitory Protein; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; D005408:Flagellin