title: Detection of motor and non-motor symptoms of end-of dose wearing-off in Parkinson's disease using a dedicated questionnaire: a Belgian multicenter survey.
abstract: In this report the usefulness of a dedicated questionnaire to detect end-of-dose wearing-off (EODWO) fluctuations in PD was studied. One hundred and sixty patients were administered an 18-item questionnaire encompassing both motor and non-motor phenomena. One hundred and eight (86%) reported EODWO, defined as the occurrence of at least one symptom improving by drug intake. Motor phenomena were significantly more frequent and non-motor phenomena never occurred in isolation. This questionnaire was deemed useful by most participants.
authors.affiliation: Dept of Neurology, Gent University Hospital, Gent, Belgium. patrick.santens@ugent.be
authors.forename: Patrick
authors.initials: P
authors.lastname: Santens
authors.forename: Alain Maertens
authors.initials: AM
authors.lastname: de Noordhout
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000175:diagnosis / Q000453:epidemiology; D001530:Belgium; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D019964:Mood Disorders / Q000175:diagnosis* / Q000453:epidemiology; D009069:Movement Disorders / Q000175:diagnosis* / Q000453:epidemiology; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D011795:Surveys and Questionnaires
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa