title: Proteomic analysis of hypertrophied myocardial protein patterns in renovascularly hypertensive and spontaneously hypertensive rats.
abstract: The cardiac protein profiles of spontaneously hypertensive and renovascularly hypertensive hypertrophy showed a significant alteration compared with normal hearts. Most proteins with significant modulations in their expressions belong to the category of metabolic and stress-related proteins. Among these proteins, glutathione-S-transferase mu2 and short-chain acyl-CoA dehydrogenase may be two candidate proteins associated with left ventricular hypertrophy in spontaneously hypertensive rats.
authors.affiliation: Pharmacology and Toxicology Laboratory and Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Si-Gui
authors.initials: SG
authors.lastname: Zhou
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Zhou
authors.forename: He-Qing
authors.initials: HQ
authors.lastname: Huang
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.forename: Pei-Qing
authors.initials: PQ
authors.lastname: Liu
mesh_terms: D042964:Acyl-CoA Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001794:Blood Pressure; D006332:Cardiomegaly / Q000235:genetics*; D004195:Disease Models, Animal; D004562:Electrocardiography; D015180:Electrophoresis, Gel, Two-Dimensional; D005982:Glutathione Transferase / Q000235:genetics; D006978:Hypertension, Renovascular / Q000235:genetics*; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics* / Q000302:isolation & purification; D020543:Proteome; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018487:Ventricular Dysfunction, Left
chemical_list: D011506:Proteins; D020543:Proteome; D012333:RNA, Messenger; D042964:Acyl-CoA Dehydrogenase; D005982:Glutathione Transferase