Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays.
New highly sensitive latent bioluminescent luciferin substrates were designed and synthesized for monitoring mammalian glutathione S-transferase (GST) and Schistosoma japonicum enzyme activities.
Zhou
Wenhui
W
Promega Biosciences Inc, San Luis Obispo, CA 93401, USA. wenhui.zhou@promega.com
Shultz
John W
JW
Murphy
Nancy
N
Hawkins
Erika M
EM
Bernad
Laurent
L
Good
Troy
T
Moothart
Leonard
L
Frackman
Susan
S
Klaubert
Dieter H
DH
Bulleit
Robert F
RF
Wood
Keith V
KV
D000818:Animals; D049454:Firefly Luciferin / Q000138:chemical synthesis / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D005982:Glutathione Transferase / Q000737:chemistry*; D007202:Indicators and Reagents; D008163:Luminescent Measurements; D015394:Molecular Structure; D012547:Schistosoma / Q000201:enzymology; D012680:Sensitivity and Specificity
D007202:Indicators and Reagents; D049454:Firefly Luciferin; D005982:Glutathione Transferase; D005978:Glutathione