title: Persistence of a sexually transmitted highly resistant HIV-1: pol quasispecies evolution over 33 months in the absence of treatment.
abstract: The evolution of a sexually transmitted multiresistant HIV-1 in a linked transmission chain was followed for 33 months to assess its potential to persist in the absence of treatment. The multiresistant HIV reverted slowly to wild type in reverse transcriptase (positions 44, 67, 74, 118) rendering the virus only susceptible to lamivudine/emtricitabine. Persistence of the replication-competent resistant HIV increases its potential to spread further and strengthens the importance of resistance testing in newly infected patients.
authors.affiliation: Medical Laboratory Prenzlauer Berg, Berlin, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Neifer
authors.forename: Sybille
authors.initials: S
authors.lastname: Somogyi
authors.forename: Frank
authors.initials: F
authors.lastname: Schlote
authors.forename: Thomas
authors.initials: T
authors.lastname: Berg
authors.forename: Gabriele
authors.initials: G
authors.lastname: Poggensee
authors.forename: Claudia
authors.initials: C
authors.lastname: Kuecherer
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics*; D000068679:Emtricitabine; D015751:Genes, pol / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D009154:Mutation / Q000235:genetics; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors; D003841:Deoxycytidine; D019259:Lamivudine; D000068679:Emtricitabine