[The genetic engineering animal models of retinoblastoma].
The article summarized the latest progress of retinoblastoma animal models using transgenetic engineering technology, and discussed the mechanism of Rb production. According to the the established animal models using current genetic engineering, the dysfunction of Rb1 gene is not the only gene in response to the development of Rb, multiple genes abnormal are required.
Yang
Zhi-wei
ZW
Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China.
Li
Yong-ping
YP
D000818:Animals; D004195:Disease Models, Animal; D016161:Genes, Retinoblastoma; D005818:Genetic Engineering; D051379:Mice; D018345:Mice, Knockout; D019572:Retinal Neoplasms / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics*