title: Quetiapine regulates the stress-induced increase in corticotropin-releasing factor mRNA expression in the rat hypothalamus.
abstract: Corticotropin-releasing factor (CRF) is a key regulator of the stress response. We investigated the effects of the atypical antipsychotic drug quetiapine on CRF mRNA expression in the rat hypothalamus following immobilization stress. Pretreatment with 10 mg/kg quetiapine significantly reduced the immobilization stress-induced increase in CRF mRNA expression in the paraventricular nucleus of the hypothalamus. These results suggest that quetiapine may modulate the stress response via regulation of CRF mRNA expression.
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Paik Inje Memorial Clinical Research Institute, Inje University, Busan, Republic of Korea.
authors.forename: Sung-Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Sun-Kyung
authors.initials: SK
authors.lastname: Lee
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Ho-Cheol
authors.initials: HC
authors.lastname: Kang
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000235:genetics / Q000378:metabolism*; D003987:Dibenzothiazepines / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D000069348:Quetiapine Fumarate; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000473:pathology* / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D012333:RNA, Messenger; D000069348:Quetiapine Fumarate; D003346:Corticotropin-Releasing Hormone