Hepatitis C virus and non-Hodgkin's lymphoma: Findings from the Swiss HIV Cohort Study.
Infections with hepatitis C virus (HCV) and, possibly, hepatitis B virus (HBV) are associated with an increased risk of non-Hodgkin's lymphoma (NHL) in the general population, but little information is available on the relationship between hepatitis viruses and NHL among people with HIV (PHIV). We conducted a matched case-control study nested in the Swiss HIV Cohort Study (SHCS). Two hundred and ninety-eight NHL cases and 889 control subjects were matched by SHCS centre, gender, age group, CD4+ count at enrollment, and length of follow-up. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using logistic regression to evaluate the association between NHL and seropositivity for antibodies against HCV (anti-HCV) and hepatitis B core antigen (anti-HBc), and for hepatitis B surface antigen (HBsAg). Anti-HCV was not associated with increased NHL risk overall (OR = 1.05; 95% CI: 0.63-1.75), or in different strata of CD4+ count, age or gender. Only among men having sex with men was an association with anti-HCV found (OR = 2.37; 95% CI: 1.03-5.43). No relationships between NHL risk and anti-HBc or HBsAg emerged. Coinfection with HIV and HCV or HBV did not increase NHL risk compared to HIV alone in the SHCS.
Franceschi
S
S
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France. franceschi@iarc.fr
Polesel
J
J
Rickenbach
M
M
Dal Maso
L
L
Probst-Hensch
N M
NM
Fux
C
C
Cavassini
M
M
Hasse
B
B
Kofler
A
A
Ledergerber
B
B
Erb
P
P
Clifford
G M
GM
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D016174:Hepacivirus; D006509:Hepatitis B / Q000150:complications; D006515:Hepatitis B virus; D006526:Hepatitis C / Q000150:complications*; D018451:Homosexuality, Male; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013557:Switzerland