title: Contribution of invariant residues to the function of Rgg family transcription regulators.
abstract: The Rgg family of transcription regulators is widely distributed among gram-positive bacteria, yet how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among Rgg-like regulators are critical for function and obtained evidence for a mechanism involving protein complex formation.
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110-1093, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Loughman
authors.forename: Michael G
authors.initials: MG
authors.lastname: Caparon
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics / Q000502:physiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015153:Blotting, Western; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D013297:Streptococcus pyogenes / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic; D014364:Tryptophan / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C098249:RopB protein, Rhizobium leguminosarum; D015534:Trans-Activators; C074779:rgg protein, Streptococcus; D014364:Tryptophan