Optimal information storage in noisy synapses under resource constraints.
Experimental investigations have revealed that synapses possess interesting and, in some cases, unexpected properties. We propose a theoretical framework that accounts for three of these properties: typical central synapses are noisy, the distribution of synaptic weights among central synapses is wide, and synaptic connectivity between neurons is sparse. We also comment on the possibility that synaptic weights may vary in discrete steps. Our approach is based on maximizing information storage capacity of neural tissue under resource constraints. Based on previous experimental and theoretical work, we use volume as a limited resource and utilize the empirical relationship between volume and synaptic weight. Solutions of our constrained optimization problems are not only consistent with existing experimental measurements but also make nontrivial predictions.
Varshney
Lav R
LR
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Sjöström
Per Jesper
PJ
Chklovskii
Dmitri B
DB
D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D016247:Information Storage and Retrieval; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology