A high-resolution single nucleotide polymorphism genetic map of the mouse genome.
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, we have constructed genetic maps for both outbred and inbred mice, and separately for males and females. Recombination rates are highly correlated in outbred and inbred mice, but show relatively low correlation between males and females. Differences between male and female recombination maps and the sequence features associated with recombination are strikingly similar to those observed in humans. Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication.
Shifman
Sagiv
S
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Bell
Jordana Tzenova
JT
Copley
Richard R
RR
Taylor
Martin S
MS
Williams
Robert W
RW
Mott
Richard
R
Flint
Jonathan
J
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D008040:Genetic Linkage; D016678:Genome; D020071:Interspersed Repetitive Sequences; D008297:Male; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid