title: Exposure and risk assessment of 1,3-butadiene in Japan.
abstract: 1,3-Butadiene is on the list of Substances Requiring Priority Action published by the Central Environmental Council of Japan in 1996. Emission of 1,3-butadiene has been controlled by a voluntary reduction program since 1997. Although the industrial emission of 1,3-butadiene in Japan has decreased in recent years, primarily due to a voluntary industrial emissions reduction program, the risks of exposure to it remain largely unknown. We assessed the risks and consequences of exposure to 1,3-butadiene on human health. A remarkable advantage of our risk assessment approach is the detailed assessment of exposure. Previously, we developed two different models that can be applied for the assessment of exposure: the first, the AIST-ADMER model estimates regional concentration distributions, whereas the second, the METI-LIS model estimates concentration distributions in the vicinity of factories. Both models were used for the assessment of exposure to 1,3-butadiene. Using exposure concentration and carcinogenic potency determined and reported by Environment Canada and Health Canada, we evaluated the excess lifetime cancer risk for persons exposed to 1,3-butadiene over the course of a lifetime. The results suggested that the majority of the population in Japan has an excess lifetime cancer risk of less than 10(-5), whereas a small number of people living close to industrial sources had a risk of greater than 10(-5). The results of the present assessment also showed that 1,3-butadiene in the general environment originates primarily from automobile emissions, such that a countermeasure of reducing emissions from cars is expected to be effective at reducing the total cancer risk among Japanese. On the other hand, individual risks among a population living in the vicinity of certain industrial sources were found to be significantly higher than those of the population living elsewhere, such that a reduction in emissions from a small number of specific industrial sources should be realized in order to reduce the high level of individual risk. Based on the results of our assessment, the Industrial Structure Council of the Ministry of Economy, Trade and Industry (METI) in Japan decided to announce that the voluntary reduction program had been successful, and that emissions reductions should no longer be targeted across all industries in general, but instead that such reductions should be carried out in a small number of selected factories that emit excessively large amounts of emissions.
authors.affiliation: Research Center for Chemical Risk Management, National Institute of Advanced Industrial Science and Technology, 16-1 Onogawa, Tsukuba, Ibaraki 305-8569, Japan. haru@ni.aist.go.jp
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Higashino
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Mita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshikado
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iwata
authors.forename: Junko
authors.initials: J
authors.lastname: Nakanishi
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis; D002070:Butadienes / Q000008:administration & dosage* / Q000009:adverse effects* / Q000032:analysis; D023381:Endpoint Determination; D004781:Environmental Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data*; D005843:Geography; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015233:Models, Statistical; D018570:Risk Assessment / Q000706:statistics & numerical data
chemical_list: D000393:Air Pollutants; D002070:Butadienes; C031763:1,3-butadiene