[Exacerbation of tonicoclonic seizures in a juvenile myoclonic epileptic taking lamotrigine].
BACKGROUND
Lamotrigine is an anti-epileptic drug considered as a first-line therapy in idiopathic generalised epilepsy. Lamotrigine is well-tolerated and secondary aggravation of epileptic syndromes has rarely been reported.


METHODS
We report the case of a 19 year-old man with juvenile myoclonic epilepsy in whom lamotrigine lead to the exacerbation of generalised tonico-clonic seizures, reversible when lamotrigine was stopped and substituted by valproic acid.


CONCLUSIONS
Lamotrogine may induce exacerbation of generalised tonico-clonic seizures and myoclonic jerks in juvenile myoclonic epilepsy.
Maiga
Y
Y
Clinique Neurologique, Hôpital Laënnec, Nantes.
Nogues
B
B
Guillon
B
B
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use*; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000150:complications; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000150:complications / Q000188:drug therapy*; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use*; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine