title: Co-morbidity of select anxiety, affective, and psychotic disorders with cannabis dependence in Southwest California Indians.
abstract: Cannabis dependence is co-morbid with psychiatric disorders in general population surveys, but whether co-morbidity exists in American Indian populations is unknown. The aim of this study was to assess co-morbidity between cannabis dependence and psychiatric disorders in a community sample of Southwest California (SWC) Indians. Demographic information and DSMIII- R diagnoses, including differentiation of independent and cannabis-induced psychiatric disorders, were obtained using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) developed for the Collaborative Study on the Genetics of Alcoholism (COGA) from 513 SWC Indian adults residing on contiguous reservations. Although SWC Indians in this sample had high rates of cannabis dependence (43% in men and 24% in women), cannabis-induced psychiatric disorders each occurred in 1% or less of the sample. No significant co-morbidity with independent psychiatric disorders was found. In SWC Indians, cannabis dependence may be less etiologically related to psychiatric disorders than in the general population.
authors.affiliation: Moleciular and and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Gilder
authors.forename: Philip
authors.initials: P
authors.lastname: Lau
authors.forename: Michelle
authors.initials: M
authors.lastname: Dixon
authors.forename: Linda
authors.initials: L
authors.lastname: Corey
authors.forename: Evelyn
authors.initials: E
authors.lastname: Phillips
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Ehlers
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000208:ethnology* / Q000209:etiology*; D002140:California / Q000453:epidemiology; D002391:Catchment Area, Health; D015897:Comorbidity; D003710:Demography; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007198:Indians, North American / Q000706:statistics & numerical data*; D008297:Male; D002189:Marijuana Abuse / Q000175:diagnosis / Q000208:ethnology* / Q000523:psychology*; D019964:Mood Disorders / Q000175:diagnosis / Q000208:ethnology* / Q000209:etiology*; D015995:Prevalence; D011618:Psychotic Disorders / Q000175:diagnosis / Q000208:ethnology* / Q000209:etiology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires