Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials.
Multipigment ensembles that feature (porphinato)metal components and appropriate ethyne- and oligoyne-based chromophore-to-chromophore connectivity can manifest large optical polarizabilities and hyperpolarizabilities by design. Their vectorial orientation and local environment are controlled upon incorporation into designed amphiphilic 4-helix bundle peptides via axial histidyl ligation without disturbing the peptide's helical secondary structure. The chromophore/peptide stoichiometry can be tuned by varying the peptide's oligomeric state. The chromophore/peptide complexes are thermally stable, making them ideal candidates for the fabrication of nonlinear optical biomolecular materials.
Xu
Ting
T
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, USA.
Wu
Sophia P
SP
Miloradovic
Ivan
I
Therien
Michael J
MJ
Blasie
J Kent
JK
D000595:Amino Acid Sequence; D001672:Biocompatible Materials / Q000737:chemistry*; D002942:Circular Dichroism; D008024:Ligands; D008969:Molecular Sequence Data; D015394:Molecular Structure; D055095:Optics and Photonics; D009942:Organometallic Compounds / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D017510:Protein Folding; D017433:Protein Structure, Secondary; D012428:Ruthenium / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013329:Structure-Activity Relationship; D013696:Temperature; D017186:Titrimetry; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry*
D001672:Biocompatible Materials; D008024:Ligands; D009942:Organometallic Compounds; D010455:Peptides; D011166:Porphyrins; D012428:Ruthenium; D015032:Zinc