Strategies for managing antidepressant-induced sexual dysfunction: a review.
Sexual dysfunction is a common side effect of most antidepressants. Lower rates are reported with some newer agents such as reboxetine and bupropion. The evidence base for its management is limited but growing, with most approaches only tested in a small number of trials. Available strategies include watchful waiting, the use of short drug holidays, and a change of antidepressant. Many specific antidotes have been trialed but with lack of convincing benefit in most cases. However, where antidepressants cause erectile dysfunction, the use of sildenafil has the largest and most consistent evidence base.
Taylor
Matthew J
MJ
University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, United Kingdom. matthew.taylor@psych.ox.ac.uk
D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016642:Bupropion / Q000008:administration & dosage / Q000009:adverse effects; D002065:Buspirone / Q000008:administration & dosage / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy*; D007172:Erectile Dysfunction / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D020441:Ginkgo biloba; D017829:Granisetron / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced* / Q000188:drug therapy
D000928:Antidepressive Agents; D016642:Bupropion; D002065:Buspirone; D017829:Granisetron