title: [Reversible dilated cardiomyopathy in a patient with acute, advanced heart failure and intense endothelial inflammatory reaction in endomyocardial biopsy--a case report].
abstract: Inflammatory response of the endothelium has been increasingly recognized in the aetiopathogenesis of sporadic dilated cardiomyopathy (DCM). It has been shown that up to 2/3 of patients with DCM have immunohistological evidence of enhanced activation of the endothelium. We present a case of a middle-aged patient with a history of hypertension and hyperlipidaemia who developed sudden significant left ventricular dysfunction following flu-like syndrome. Endomyocardial biopsy revealed no myocarditis, but immunohistological features of endothelial activation were present. Additionally, increasing titers of IgG antibodies against PvB19 were observed. During 18 months of standard heart failure treatment along with statin therapy, we observed a significant recovery of left ventricular systolic function, and in this way, reversible dilated cardiomyopathy.
authors.affiliation: I Klinika Choroby Wieńcowej, Instytut Kardiologii, ul. Alpejska 42, 04-628 Warszawa. medykpol@wp.pl
authors.forename: Paweł
authors.initials: P
authors.lastname: Tyczyński
authors.forename: Zofia T
authors.initials: ZT
authors.lastname: Bilińska
authors.forename: Zofia
authors.initials: Z
authors.lastname: Dzielińska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Cedro
authors.forename: Jacek
authors.initials: J
authors.lastname: Grzybowski
authors.forename: Ewa
authors.initials: E
authors.lastname: Walczak
authors.forename: Ewa
authors.initials: E
authors.lastname: Michalak
authors.forename: Teresa
authors.initials: T
authors.lastname: Wagner
authors.forename: Witold
authors.initials: W
authors.lastname: Ruzyłło
mesh_terms: D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000276:immunology* / Q000473:pathology / Q000821:virology; D004699:Endocardium / Q000276:immunology* / Q000473:pathology / Q000821:virology; D004730:Endothelium, Vascular / Q000473:pathology; D006333:Heart Failure / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000276:immunology* / Q000473:pathology / Q000821:virology; D010322:Parvoviridae Infections / Q000150:complications*; D018487:Ventricular Dysfunction, Left / Q000276:immunology / Q000473:pathology / Q000821:virology