title: Antidiabetic, antioxidant and antihyperlipidemic status of Heliotropium zeylanicum extract on streptozotocin-induced diabetes in rats.
abstract: The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration of (MEHZ) 150 and 300 mg/kg/d for 14 d significantly decreased the blood glucose level and considerably increased the body weight, food intake, and liquid intake of diabetic-induced rats. MEHZ significantly decreased thiobarbituric acid reactive substances and significantly increased reduced glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 14 d of treatment. The study also investigated the antihyperlipidemic potential of MEHZ. The results show that the active fraction of MEHZ is promising for development of a standardized phytomedicine for the treatment of diabetes mellitus.
authors.affiliation: Department of Pharmaceutical Technology, Division of Pharmaceutical Chemistry, Jadavpur University, Kolkata, India. sarugesh@yahoo.com
authors.forename: Kandasamy
authors.initials: K
authors.lastname: Murugesh
authors.forename: Veerendra
authors.initials: V
authors.lastname: Yeligar
authors.forename: Deepak Kumar
authors.initials: DK
authors.lastname: Dash
authors.forename: Pinaki
authors.initials: P
authors.lastname: Sengupta
authors.forename: Bhim Chandra
authors.initials: BC
authors.lastname: Maiti
authors.forename: Tapan Kumar
authors.initials: TK
authors.lastname: Maity
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D028162:Heliotropium / Q000737:chemistry*; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014044:Tolbutamide / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D013311:Streptozocin; D014044:Tolbutamide; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione