title: Lipid deposition on silicone hydrogel lenses, part I: quantification of oleic Acid, oleic Acid methyl ester, and cholesterol.
abstract: OBJECTIVE
  To investigate the sorption of oleic acid, oleic acid methyl ester, and cholesterol on currently marketed silicone hydrogel contact lenses.
  
  
  METHODS
  Two liquid chromatography methods were developed and used to analyze lens extracts from continuous-wear and daily-wear modalities from asymptomatic silicone hydrogel contact lens wearers.
  
  
  RESULTS
  Of the three probed compounds, cholesterol is the most prevalently sorbed, at levels ranging from below the limit of quantitation (<1.50 microg per lens) to approximately 37.0 microg per lens. Oleic acid and oleic acid methyl ester were found to exist at levels below the limit of quantitation (<1.50 microg per lens). In general, there appears to be no significant difference between the amounts of cholesterol sorbed on the continuous-wear PureVision and daily-wear PureVision lenses evaluated.
  
  
  CONCLUSIONS
  The quantities of lipid sorbed to continuous-wear PureVision lenses are significantly different from those previously reported by other authors in a similarly conducted experiment. This difference suggests that any hypothesis of silicone hydrogel lenses based on these previous lipid data should be reconsidered.
authors.affiliation: Bausch & Lomb, Inc., Rochester, NY 14603, USA.
authors.forename: E Peter
authors.initials: EP
authors.lastname: Maziarz
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Stachowski
authors.forename: X Michael
authors.initials: XM
authors.lastname: Liu
authors.forename: Linda
authors.initials: L
authors.lastname: Mosack
authors.forename: Ann
authors.initials: A
authors.lastname: Davis
authors.forename: Connie
authors.initials: C
authors.lastname: Musante
authors.forename: David
authors.initials: D
authors.lastname: Heckathorn
mesh_terms: D000042:Absorption; D002784:Cholesterol / Q000378:metabolism*; D003263:Contact Lenses, Hydrophilic; D004952:Esters; D006801:Humans; D020100:Hydrogels; D050356:Lipid Metabolism; D019301:Oleic Acid / Q000378:metabolism*; D012828:Silicones
chemical_list: D004952:Esters; D020100:Hydrogels; D012828:Silicones; D019301:Oleic Acid; D002784:Cholesterol