The protective effect of aloe vera juice on lindane induced hepatotoxicity and genotoxicity.
The protective effect of fresh aloe vera (AV) leaves extract on lindane (LD) - induced hepatoxicity and genotoxicity was studied. Serum levels of hepatic enzyme markers: glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) were determined after oral administration of aloe vera leaves extract and lindane. The level of polychromatic erythrocytes was also observed. Pretreatment with aloe vera leaves extract at concentration of 1.0 ml/kg body weight significantly decreased (P<0.05) the serum levels of GPT (by 41.8%), GOT (by 36.5%), GGT (by 14.3%) and ALP (by 10.7%) induced by 100mg/kg body weight of lindane. The level of polychromatic erythrocytes observed was not statistically significant when compared to control.
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Department of Biochemistry, Faculty of Basic Medical Sciences University of Uyo, Uyo, Nigeria. yirebong_123@yahoo.com
Farombi
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Usoh
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Akpan
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D000504:Aloe; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D001556:Hexachlorocyclohexane