Mechanisms for recovery of motor function following cortical damage.
Recent studies of focal injury to the cerebral cortex have demonstrated that the remaining, intact tissue undergoes structural and functional changes that could play a substantial role in neurological recovery. New information regarding the molecular and cellular environment in the adjacent, intact tissue has suggested that waves of growth promotion and inhibition modulate the self-repair processes of the brain. Furthermore, recent studies have documented widespread neurophysiological and neuroanatomical changes in regions remote from a focal cortical injury, suggesting that entire cortical networks participate in the recovery process.
Nudo
Randolph J
RJ
University of Kansas Medical Center, Landon Center on Aging, MS 1005 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. rnudo@kumc.edu
D000818:Animals; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000503:physiopathology*; D020439:Growth Cones / Q000378:metabolism; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism; D009415:Nerve Net / Q000033:anatomy & histology / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D010291:Paresis / Q000209:etiology / Q000503:physiopathology*; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000503:physiopathology*
D009414:Nerve Growth Factors