title: Bonabiline A, a monoterpenoid 3alpha-acyloxytropane from the roots of Bonamia spectabilis showing M3 receptor antagonist activity.
abstract: Two 3alpha-acyloxytropanes with unique monoterpenoic acyl moieties, bonabiline A and its anhydro derivative bonabiline B, have been isolated from the roots of Bonamia spectabilis. Their structures were elucidated by detailed spectroscopic analysis. Due to the structural similarity of bonabiline A to atropine/hyoscyamine, the affinity of both bonabilines to the muscarinic M (3) receptor was studied in the isolated guinea-pig ileum. Bonabiline A (pA (2) 6.65 +/- 0.03) proved to be a more potent antagonist than bonabiline B (pA (2) 5.50 +/- 0.03).
authors.affiliation: Institut für Pharmazie, Pharmazeutische Biologie, Freie Universität Berlin, Berlin, Germany.
authors.forename: Sonja C
authors.initials: SC
authors.lastname: Ott
authors.forename: Kristina
authors.initials: K
authors.lastname: Jenett-Siems
authors.forename: Heinz H
authors.initials: HH
authors.lastname: Pertz
authors.forename: Karsten
authors.initials: K
authors.lastname: Siems
authors.forename: Ludger
authors.initials: L
authors.lastname: Witte
authors.forename: Eckart
authors.initials: E
authors.lastname: Eich
mesh_terms: D000818:Animals; D041601:Bonamia Plant; D002217:Carbachol; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D039821:Monoterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D043587:Receptor, Muscarinic M3 / Q000037:antagonists & inhibitors*
chemical_list: D039821:Monoterpenes; D018727:Muscarinic Antagonists; D010936:Plant Extracts; D043587:Receptor, Muscarinic M3; C517588:bonabiline A; D002217:Carbachol