[Effect of streptokinase on the content of plasminogen activator inhibitor of type 1].
The influence of streptokinase on plasminogen activators inhibitor of type I (PAI-1) was investigated with the use of model systems in vitro and in vivo. It was defined, that intravenous streptokinase injection causes an increase in PAI-1 content in mammals' blood plasma. Experiments in vitro have shown that the increase in PAI-1 concentration takes place as a result of streptokinase action. It occurs due to platelets activation with subsequent PAI-1 secretion from their a-granules. It is established, that PAI-1 is secreted by platelets both in free and in complex forms. The data obtained in the work, allow to assume, that the simultaneous substantial increase in PAI-1 content with platelets activation, as a result of streptokinase influence, can lead to new thrombotic complications risk.
Burlova-Vasil'eva
N K
NK
Krasnobryzha
Ie M
IeM
Savchuk
O M
OM
Volkov
H L
HL
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D015153:Blotting, Western; D006487:Hemostasis / Q000187:drug effects; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D015539:Platelet Activation / Q000187:drug effects; D011817:Rabbits; D013300:Streptokinase / Q000494:pharmacology*; D013552:Swine
D017395:Plasminogen Activator Inhibitor 1; D013300:Streptokinase