The vasohibin family: a negative regulatory system of angiogenesis genetically programmed in endothelial cells.
Biological phenomena are under the precise control by the genome. For the regulation of angiogenesis, proangiogenic genes such as VEGFs and angiopoietins are highly conserved, act specifically on endothelial cells, and play a fundamental role. In this sense, nature should prepare specific antiangiogenic genes as well. However, this counterpart of genomic regulation of angiogenesis remains to be established. We recently isolated a novel endothelium-derived angiogenesis inhibitor and named it vasohibin. Vasohibin is dominantly expressed in endothelial cells, induced by the stimulation with VEGF or FGF-2, and selectively affects on endothelial cells and inhibits angiogenesis. Although the mechanism of how vasohibin inhibits angiogenesis remains to be elucidated, our discovery of vasohibin as an endothelium-derived VEGF-inducible angiogenesis inhibitor should shed light on the genomic basis of the negative regulation of angiogenesis.
Sato
Yasufumi
Y
Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. y-sato@idac.tohoku.ac.jp
Sonoda
Hikaru
H
D017398:Alternative Splicing; D020533:Angiogenesis Inhibitors / Q000235:genetics / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D025461:Feedback, Physiological / Q000235:genetics / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D020533:Angiogenesis Inhibitors; D018797:Cell Cycle Proteins; C493181:VASH1 protein, human; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2