title: 19F NMR as a powerful technique for the assay of anti-psychotic drug haloperidol in human serum and pharmaceutical formulations.
abstract: 19F nuclear magnetic resonance was used as a suitable analytical tool for the identification and selective determination of haloperidol in human serum and pharmaceutical preparations. The method is based on the integration of appropriate signals of haloperidol and trifluoroacetic acid as an internal standard. The proposed method is a rapid and facile, while without any sample pretreatment, manipulation of large samples and lengthy instrument time. The regression equation for haloperidol in human serum showed a good linearity in the range of 60-600 microg ml(-1) with a detection limit of 1.4 microg ml(-1). The mean recovery results on human serum samples ranged from about 96-103%, with relative standard deviations <8%. The method was also applied successfully to the determination of haloperidol in real pharmaceutical samples, and compared with the results obtained by a reference method. The drug's degradation was studied by the proposed method in hydrochloric acid media and main products were identified.
authors.affiliation: Department of Chemistry, Razi University, Kermanshah, Iran. mshamsipur@yahoo.com
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Shamsipur
authors.forename: Leila
authors.initials: L
authors.lastname: Shafiee-Dastgerdi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Talebpour
authors.forename: Soheila
authors.initials: S
authors.lastname: Haghgoo
mesh_terms: D014150:Antipsychotic Agents / Q000032:analysis* / Q000097:blood*; D002138:Calibration; D006220:Haloperidol / Q000032:analysis* / Q000097:blood*; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D012015:Reference Standards; D015203:Reproducibility of Results; D013607:Tablets / Q000032:analysis
chemical_list: D014150:Antipsychotic Agents; D007202:Indicators and Reagents; D013607:Tablets; D006220:Haloperidol