Different roles of the two high-oxygen-affinity terminal oxidases of Brucella suis: Cytochrome c oxidase, but not ubiquinol oxidase, is required for persistence in mice.
The survival of Brucella suis mutant strains in mice demonstrated different roles of the two high-oxygen-affinity terminal oxidases. The cbb3-type cytochrome c oxidase was essential for chronic infection in oxygen-deficient organs. Lack of the cytochrome bd ubiquinol oxidase led to hypervirulence of bacteria, which could rely on nitrite accumulation inhibiting the inducible nitric oxide synthase of the host.
Jiménez de Bagüés
Maria Pilar
MP
Institut National de la Santé et de la Recherche Médicale, U431, Montpellier, F-34095 France.
Loisel-Meyer
Séverine
S
Liautard
Jean-Pierre
JP
Jubier-Maurin
Véronique
V
D000818:Animals; D041021:Brucella suis / Q000201:enzymology / Q000472:pathogenicity*; D002006:Brucellosis / Q000201:enzymology*; D004195:Disease Models, Animal; D003576:Electron Transport Complex IV / Q000378:metabolism*; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010088:Oxidoreductases / Q000378:metabolism*
D010088:Oxidoreductases; C432586:ubiquinol oxidase; D003576:Electron Transport Complex IV