Encapsulation of ketoprofen for controlled drug release.
Ketoprofen particles were encapsulated with polyions and gelatin to control the release of the drug in aqueous solutions. Charged linear polyions and gelatin were alternatively deposited on 6 microm drug microcrystals through layer-by-layer (LbL) assembly. Sequential layers of poly(dimethyldiallyl ammonium chloride) (PDDA) and poly(styrenesulfonate) (PSS) were followed by adsorption of two to six gelatin/PSS bilayers with corresponding capsule wall thicknesses ranging from 41 to 111 nm. The release of Ketoprofen from the coated microparticles was measured in aqueous solutions of pH 1.4, 4.1, and 7.4. The release rate has changed at these different pH values. At pH 7.4 the release rate of Ketoprofen from the encapsulated particles was less by 107 times compared to uncoated Ketoprofen. The results provide a method of achieving prolonged drug release through self-assembly of polymeric shells on drug crystals.
Arida
Adi I
AI
Faculty of Pharmacy, Philadelphia University, Jerash, Jordan. arida@go.com.jo
Al-Tabakha
Moawia M
MM
D019342:Acetic Acid / Q000737:chemistry; D000327:Adsorption; D003460:Crystallization; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods*; D005780:Gelatin / Q000737:chemistry; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D007097:Imines / Q000737:chemistry; D007660:Ketoprofen / Q000737:chemistry* / Q000493:pharmacokinetics; D007700:Kinetics; D015394:Molecular Structure; D010316:Particle Size; D011095:Polyethylenes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011791:Quartz / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D012995:Solubility; D012996:Solutions / Q000737:chemistry; D055672:Static Electricity; D013451:Sulfonic Acids / Q000737:chemistry
D016861:Cyclooxygenase Inhibitors; D003692:Delayed-Action Preparations; D007097:Imines; D011095:Polyethylenes; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D012996:Solutions; D013451:Sulfonic Acids; C505405:poly(ethylene imine); D011791:Quartz; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; D012965:Sodium Chloride; D005780:Gelatin; D007660:Ketoprofen; D019342:Acetic Acid; C077114:styrenesulfonic acid polymer