title: Eosinophilic esophagitis: pathogenesis, genetics, and therapy.
abstract: Eosinophilic esophagitis (EE) is a recently recognized disorder characterized by the accumulation of eosinophils in the esophagus. Symptoms of EE frequently mimic those of gastroesophageal reflux disease, but the 2 diseases are quite distinct in terms of the histopathology and response to therapy. We demonstrate that EE involves the interplay of numerous genes, especially the eosinophil chemoattractant eotaxin-3, allowing molecular distinction from other forms of esophagitis and consideration of targeted therapeutic intervention.
authors.affiliation: Division of Allergy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Carine
authors.initials: C
authors.lastname: Blanchard
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Marc E
authors.initials: ME
authors.lastname: Rothenberg
mesh_terms: D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000628:therapy; D004941:Esophagitis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics* / Q000628:therapy; D006801:Humans