title: Recurring genomic breaks in independent lineages support genomic fragility.
abstract: BACKGROUND
  Recent findings indicate that evolutionary breaks in the genome are not randomly distributed, and that certain regions, so-called fragile regions, are predisposed to breakages. Previous approaches to the study of genomic fragility have examined the distribution of breaks, as well as the coincidence of breaks with segmental duplications and repeats, within a single species. In contrast, we investigate whether this regional fragility is an inherent genomic characteristic and is thus conserved over multiple independent lineages.
  
  
  RESULTS
  We do this by quantifying the extent to which certain genomic regions are disrupted repeatedly in independent lineages. Our investigation, based on Human, Chimp, Mouse, Rat, Dog and Chicken, suggests that the propensity of a chromosomal region to break is significantly correlated among independent lineages, even when covariates are considered. Furthermore, the fragile regions are enriched for segmental duplications.
  
  
  CONCLUSIONS
  Based on a novel methodology, our work provides additional support for the existence of fragile regions.
authors.affiliation: Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA, USA. hhinsch@yahoo.com <hhinsch@yahoo.com>
authors.forename: Hanno
authors.initials: H
authors.lastname: Hinsch
authors.forename: Sridhar
authors.initials: S
authors.lastname: Hannenhalli
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002645:Chickens / Q000235:genetics; D019457:Chromosome Breakage; D004285:Dogs; D005819:Genetic Markers / Q000235:genetics; D042822:Genomic Instability / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006801:Humans; D051379:Mice; D002679:Pan troglodytes / Q000235:genetics; D051381:Rats
chemical_list: D005819:Genetic Markers