title: Interferon beta adenoviral gene therapy in a patient with ovarian cancer.
abstract: Background A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon beta gene therapy. Investigations Abdominal and chest CT scans, 2-[(18)F]fluoro-2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses. Diagnosis Stage IV ovarian cancer with malignant ascites and pleural effusion. Management Tunneled pleural catheter and intrapleural adenoviral-mediated interferon beta gene therapy.
authors.affiliation: Thoracic Oncology Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Sterman
authors.forename: Colin T
authors.initials: CT
authors.lastname: Gillespie
authors.forename: Richard G
authors.initials: RG
authors.lastname: Carroll
authors.forename: Christina M
authors.initials: CM
authors.lastname: Coughlin
authors.forename: Elaina M
authors.initials: EM
authors.lastname: Lord
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Andrew
authors.initials: A
authors.lastname: Haas
authors.forename: Adri
authors.initials: A
authors.lastname: Recio
authors.forename: Larry R
authors.initials: LR
authors.lastname: Kaiser
authors.forename: George
authors.initials: G
authors.lastname: Coukos
authors.forename: Carl H
authors.initials: CH
authors.lastname: June
authors.forename: Steven M
authors.initials: SM
authors.lastname: Albelda
authors.forename: Robert H
authors.initials: RH
authors.lastname: Vonderheide
mesh_terms: D000256:Adenoviridae; D001201:Ascites / Q000209:etiology; D005260:Female; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D016899:Interferon-beta / Q000235:genetics* / Q000627:therapeutic use*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000628:therapy*; D010996:Pleural Effusion / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D016899:Interferon-beta