Unusual histological findings in a child with idiopathic nephrotic syndrome.
We report a 2-year-old child with corticosteroid-resistant nephrotic syndrome whose renal biopsy revealed light microscopically normal glomeruli but highly unusual finger-like projections and arches of the glomerular basement membrane. To our knowledge, the association between nephrotic syndrome and this patient's rare ultrastuctural lesion has not been previously documented in the literature. It is not certain whether this basement membrane is pathogenic or a striking but coincidental developmental anomaly.
Springate
James
J
Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York, and Division of Nephrology, Women and Children's Hospital, Buffalo, NY, 14214, USA. jspringate@upa.chob.edu
Nadasdy
Tibor
T
D002675:Child, Preschool; D005260:Female; D050533:Glomerular Basement Membrane / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000473:pathology*