title: Nor-seco-cucurbit[10]uril exhibits homotropic allosterism.
abstract: The condensation of glycoluril and formaldehyde in concentrated HCl at 50 degrees C delivers nor-seco-cucurbit[10]uril (ns-CB [10]). 1H NMR and X-ray crystallographic evidence indicates that the two cavities of ns-CB[10] accommodate guests that are typically bound within CB[6] or CB[7]. Several interesting types of selectivity are possible within these ternary complexes-top/center isomerism, diastereoselective complexation of chiral (but racemic) guest pairs, and guest size controlled homotropic allosterism.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
authors.forename: Wei-Hao
authors.initials: WH
authors.lastname: Huang
authors.forename: Simin
authors.initials: S
authors.lastname: Liu
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Zavalij
authors.forename: Lyle
authors.initials: L
authors.lastname: Isaacs