title: Biodegradable microparticles based on poly(D,L-lactide) as a protective transport system in ruminant digestion.
abstract: Despite its abundance in their diet, cattle are unable to directly digest cellulose. The bovine digestive tract overcomes this problem via the rumen, a portion of the stomach containing mixed anaerobic bacteria. These microbes, while breaking down foodstuffs, also perform undesirable processes such as biohydrogenation, in which unsaturated fatty acids become saturated, with deleterious cardiovascular effects. An approach to preventing this saturation entailing the use of polymeric microspheres to encapsulate feed supplements is proposed, with a single emulsion, solvent evaporation method used to formulate poly(D,L-lactide) microparticles for delivery of unsaturated fatty acids to ruminant abomasum.
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Jay
authors.forename: Nolan J
authors.initials: NJ
authors.lastname: Peevy
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Jenkins
authors.forename: Karen J L
authors.initials: KJ
authors.lastname: Burg
mesh_terms: D000818:Animals; D001692:Biological Transport; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002417:Cattle; D019587:Dietary Supplements; D004063:Digestion; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D008660:Metabolism; D008863:Microspheres; D011091:Polyesters / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012418:Ruminants / Q000502:physiology
chemical_list: D005231:Fatty Acids, Unsaturated; D011091:Polyesters; C033616:poly(lactide)