title: Two-level antibacterial coating with both release-killing and contact-killing capabilities.
abstract: Using a combination of an aqueous layer-by-layer deposition technique, nanoparticle surface modification chemistry, and nanoreactor chemistry, we constructed thin film coatings with two distinct layered functional regions: a reservoir for the loading and release of bactericidal chemicals and a nanoparticle surface cap with immobilized bactericides. This results in dual-functional bactericidal coatings bearing both chemical-releasing bacteria-killing capacity and contact bacteria-killing capacity. These dual-functional coatings showed very high initial bacteria-killing efficiency due to the release of Ag ions and retained significant antibacterial activity after the depletion of embedded Ag because of the immobilized quaternary ammonium salts.
authors.affiliation: Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Daeyeon
authors.initials: D
authors.lastname: Lee
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Sheng
authors.forename: Robert E
authors.initials: RE
authors.lastname: Cohen
authors.forename: Michael F
authors.initials: MF
authors.lastname: Rubner
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion; D004573:Electrolytes; D007477:Ions; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004573:Electrolytes; D007477:Ions; D000644:Quaternary Ammonium Compounds; D012834:Silver; D012822:Silicon Dioxide