title: Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development.
abstract: Recently, sequence analyses have identified a large number of opposite strand transcripts in the vertebrate genome. Although the transcripts appear to be spliced and polyadenylated, many of them are predicted to represent noncoding RNAs. High levels of noncoding transcripts of the Six3 Opposite Strand (Six3OS) were recently identified in the embryonic and postnatal retina of the mouse. In this study, we expanded those initial expression analyses, elucidated in detail the developmental expression profile of mouse Six3OS in the brain and visual system, and compared it with that of Six3. Our results show that Six3OS expression overlaps extensively with that of Six3 and is not altered in Six3-null embryos.
authors.affiliation: Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Geng
authors.forename: Alfonso
authors.initials: A
authors.lastname: Lavado
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Lagutin
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Guillermo
authors.initials: G
authors.lastname: Oliver
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology; D004622:Embryo, Mammalian / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics*; D005136:Eye Proteins / Q000235:genetics*; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics*; D051379:Mice; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016372:RNA, Antisense / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*; D012160:Retina / Q000196:embryology / Q000378:metabolism; D000097607:Homeobox Protein SIX3
chemical_list: D005136:Eye Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D016372:RNA, Antisense; D022661:RNA, Untranslated; D000097607:Homeobox Protein SIX3