Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.
In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 microM. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
Weber
Daniela
D
Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
Erosa
Gilda
G
Sterner
Olov
O
Anke
Timm
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000032:analysis; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D021903:DNA, Ribosomal Spacer; D010456:Peptides, Cyclic; C515293:cylindrocyclin A