Ultrasound promoted protection of alcohols: an efficient solvent-free pathway for the preparation of silyl ethers in the presence of no additive.
Various types of alcohols and phenols were rapidly protected by hexamethyldisilazane in good to excellent yields at room temperature using high-intensity ultrasound irradiation in the presence of no solvent or any additive. Good to excellent chemoselectivity was observed for competitive protection of hydroxyl groups in favor of sterically less hindered alcohols. Exclusive protection of phenols in the presence of aromatic amines was also demonstrated successfully.
Mojtahedi
Mohammad M
MM
Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186 Tehran, Iran. Electronic address: mojtahedi@ccerci.ac.ir.
Saeed Abaee
M
M
Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186 Tehran, Iran.
Hamidi
Vahid
V
Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186 Tehran, Iran.
Zolfaghari
Alireza
A
Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186 Tehran, Iran.