Rapid systemic bone resorption during the course of Staphylococcus aureus-induced arthritis.
Bacterial arthritis is the most rapidly progressing destructive joint disease in humans. To evaluate bone resorption and formation, mice were injected with Staphylococcus aureus and killed after 3 and 14 days. Both total and trabecular bone mineral density were, compared with those in uninfected controls, already significantly reduced 3 days after bacterial inoculation. Serum levels of type I collagen fragments were significantly increased and osteocalcin levels decreased in mice infected with S. aureus, compared with those in noninfected mice, 3 and 14 days after bacterial inoculation. This study shows that there is a rapid and easily measurable systemic bone resorption during S. aureus-induced arthritis.
Verdrengh
Margareta
M
Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, S-41346 Goteborg, Sweden. margareta.verdrengh@rheuma.gu.se
Carlsten
Hans
H
Ohlsson
Claes
C
Tarkowski
Andrej
A
D000818:Animals; D001170:Arthritis, Infectious / Q000150:complications* / Q000382:microbiology*; D015519:Bone Density; D001862:Bone Resorption / Q000209:etiology*; D024042:Collagen Type I / Q000097:blood; D051379:Mice; D015675:Osteocalcin / Q000097:blood; D013203:Staphylococcal Infections / Q000150:complications* / Q000382:microbiology*; D013211:Staphylococcus aureus
D024042:Collagen Type I; D015675:Osteocalcin