title: Aspects on radionuclide therapy in malignant pheochromocytomas.
abstract: Malignant pheochromocytomas/paragangliomas (PCs/PGs) often have distant metastases to the skeleton, liver, and lungs. Radionuclide therapy is valuable for treatment of disseminated tumor disease and could be used as adjuvant therapy after surgery. Patients with local and/or distant metastases of PC/PG should be investigated preoperatively by scintigraphy using both 123I-MIBG and 111In-DTPA-D-Phe1-octreotide, to evaluate the possibilities for radionuclide therapy (i.e., a dosimetric estimation of radiation dose to the tumor tissue versus critical normal tissues). Individual patient dose-planning should be performed. For patients in whom positive therapeutic effects are anticipated radionuclide therapy can be applied. Therapy with both 131I-MIBG and 177Lu-octreotate might be favorable in individual patients with lesions visualized by both metaiodobenzylguanidine (MIBG) and octreotide scintigraphy with enhanced therapeutic effects and reduced side effects.
authors.affiliation: Department of Radiation Physics, Lundberg Laboratory for Cancer Research, Göteborg University, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden. eva.forssell_aronsson@radfys.gu.se
authors.forename: Eva
authors.initials: E
authors.lastname: Forssell-Aronsson
authors.forename: Peter
authors.initials: P
authors.lastname: Bernhardt
authors.forename: Bo
authors.initials: B
authors.lastname: Wängberg
authors.forename: Lars
authors.initials: L
authors.lastname: Kölby
authors.forename: Ola
authors.initials: O
authors.lastname: Nilsson
authors.forename: Håkan
authors.initials: H
authors.lastname: Ahlman
mesh_terms: D019797:3-Iodobenzylguanidine / Q000627:therapeutic use*; D000310:Adrenal Gland Neoplasms / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D010673:Pheochromocytoma / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes; D019797:3-Iodobenzylguanidine