title: Fertility in men with Down syndrome: a case report.
abstract: OBJECTIVE
  To inform clinicians about fertility in males with Down syndrome.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Medical Genetics Department of a tertiary-care hospital.
  
  
  METHODS
  A 26-year-old man with confirmed nonmosaic trisomy 21.
  
  
  METHODS
  Karyotype, amniocentesis, paternity testing using microsatellite markers.
  
  
  METHODS
  Confirmed paternity in the son of a male with nonmosaic trisomy 21.
  
  
  RESULTS
  A male with nonmosaic Down syndrome fathered a normal son, and the paternity was proven by microsatellite marker analysis.
  
  
  CONCLUSIONS
  Although Down syndrome males have been reported to be infertile, it may not always be true. Infertility in males has been attributed to defective spermatogenesis, but ignorance of the sexual act may be one of the contributing factors. It is important to advise postpubertal Down syndrome males on contraceptive measures.
authors.affiliation: Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. mandakini@sgpgi.ac.in <mandakini@sgpgi.ac.in>
authors.forename: Mandakini
authors.initials: M
authors.lastname: Pradhan
authors.forename: Ashwin
authors.initials: A
authors.lastname: Dalal
authors.forename: Faisal
authors.initials: F
authors.lastname: Khan
authors.forename: Suraksha
authors.initials: S
authors.lastname: Agrawal
mesh_terms: D000328:Adult; D004314:Down Syndrome; D005298:Fertility; D006801:Humans; D008297:Male