Albumin functions as an inhibitor of T cell adhesion in vitro.
Jurkat T cells were found to adhere to a tissue culture flask or cover glass when 10% fetal bovine serum (FBS) was withdrawn. However, the cells adhered to extracellular matrix, especially fibronectin, regardless of the presence of FBS. We hypothesized that a substance in FBS inhibits T cells' adherence. Through a purification and identification procedure performed on the substance, bovine serum albumin (BSA) was found to inhibit T cell adhesion. BSA, furthermore, inhibited the adhesion of human primary cultured T cells. These results suggest a novel function for albumin as a T cell adhesion inhibitor.
Kim
Yu-Lee
YL
Laboratory of Pharmacology, College of Pharmacy and Research Institute for Drug Development, Pusan National University, San 30, Jang-Jun-dong, Geum-Jung-gu, Busan 609-735, Republic of Korea.
Im
Young-Jin
YJ
Lee
Yun-Kyung
YK
Ha
Nam-Chul
NC
Bae
Yoe-Sik
YS
Lim
Sung-Mee
SM
Okajima
Fumikazu
F
Im
Dong-Soon
DS
D000818:Animals; D002417:Cattle; D002448:Cell Adhesion / Q000187:drug effects*; D006801:Humans; D019169:Jurkat Cells; D044967:Serum / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000032:analysis / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology
D012710:Serum Albumin, Bovine