An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius.
The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC(50) value of 0.31 microg/ml, a level of inhibition comparable to that of tamoxifen (IC(50) = 0.43 microg/ml).
Yoo
Hye Hyun
HH
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.
Park
Jeong Hill
JH
Kwon
Sung Won
SW
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D031187:Carthamus tinctorius / Q000737:chemistry*; D002460:Cell Line; D004789:Enzyme Activation / Q000187:drug effects; D004967:Estrogens / Q000378:metabolism*; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D012995:Solubility
D004967:Estrogens; D005960:Glucosides; D006027:Glycosides; D017705:Lignans; D010936:Plant Extracts; C079169:tracheloside; D015107:4-Butyrolactone