Influences on circulating oestrogens in postmenopausal women: relationship with breast cancer.
Sex hormones are intrinsically linked to the development and treatment of the majority of breast cancers. High oestradiol levels are associated with elevated breast cancer risk in the postmenopausal setting and are given increasing importance in determining chemoprevention target groups. This review aims to evaluate the impact of various lifestyle factors including body mass index, diet, smoking, and alcohol on normal physiological sex hormone profiles. The role of genetic polymorphisms is also discussed, and all are placed within the context of designing future epidemiological studies and breast cancer risk algorithms.
Kendall
Anne
A
Academic Department of Biochemistry, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom.
Folkerd
Elizabeth J
EJ
Dowsett
Mitch
M
D001943:Breast Neoplasms / Q000097:blood* / Q000235:genetics; D004967:Estrogens / Q000097:blood* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008019:Life Style; D008954:Models, Biological; D017698:Postmenopause / Q000097:blood*
D004967:Estrogens; D012739:Gonadal Steroid Hormones