Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa.
The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.
Piazzi
G
G
1Centre of Applied Biomedical Research (CRBA), S Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy. giulia.piazzi@yahoo.it
Paterini
P
P
Ceccarelli
C
C
Pantaleo
M A
MA
Biasco
G
G
D000368:Aged; D015179:Colorectal Neoplasms / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000032:analysis; D012007:Rectum / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D012333:RNA, Messenger; D066246:ErbB Receptors