A SUMOry of DNA replication: synthesis, damage, and repair.
Recombination at stalled replication forks is regulated at an early stage by sumoylation. In this issue of Cell, Branzei et al. show that the Ubc9/SUMO modification pathway controls the accumulation of cruciform structures at stalled forks.
Klein
Hannah L
HL
Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA. hannah.klein@med.nyu.edu
D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D004271:DNA, Fungal / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics / Q000378:metabolism*
D004271:DNA, Fungal; D044763:Ubiquitin-Conjugating Enzymes