Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children.
To characterize a host polygenic profile associated with susceptibility to human T lymphotropic virus type I (HTLV-I) infection, we examined common variants in 11 immune-related genes among Jamaican children born to HTLV-I-seropositive mothers. Compared with HTLV-I seronegatives, haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding (odds ratio [OR], 4.5 [95% confidence interval {CI}, 1.2-17.6], and OR, 3.5 [95% CI, 1.4-9.0], respectively). Our findings are the first, to our knowledge, to suggest that host variation in both proinflammatory and anti-inflammatory genes could influence susceptibility to HTLV-I infection.
Brown
Elizabeth E
EE
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA. brownbe@mail.nih.gov
Brown
Brandon J
BJ
Yeager
Meredith
M
Welch
Robert
R
Cranston
Beverly
B
Hanchard
Barrie
B
Hisada
Michie
M
D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D015490:HTLV-I Infections / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D007563:Jamaica; D008297:Male
D015850:Interleukin-6; D016753:Interleukin-10