title: hOGG1 Ser326Cys polymorphism and risk of hepatocellular carcinoma among Japanese.
abstract: BACKGROUND
  The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC).
  
  
  METHODS
  We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC.
  
  
  RESULTS
  Overall, the hOGG1 genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69).
  
  
  CONCLUSIONS
  These results suggest that the hOGG1 Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis.
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga. sakamott@med.saga-u.ac.jp
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Higaki
authors.forename: Megumi
authors.initials: M
authors.lastname: Hara
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ichiba
authors.forename: Mikako
authors.initials: M
authors.lastname: Horita
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Mizuta
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Eguchi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yasutake
authors.forename: Iwata
authors.initials: I
authors.lastname: Ozaki
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Onohara
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawazoe
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Shigematsu
authors.forename: Shunzo
authors.initials: S
authors.lastname: Koizumi
authors.forename: Keitaro
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012694:Serine / Q000235:genetics
chemical_list: D012694:Serine; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human