Effects of dietary myo-inositol, D-chiro-inositol and L-chiro-inositol on hepatic lipids with reference to the hepatic myo-inositol status in rats fed on 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane.
The effects of dietary 0.2% inositol stereoisomers on the hepatic lipids and myo-inositol (MI) status in rats fed with 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) were investigated. Dietary MI reduced the hepatic lipids in the rats fed with DDT. Dietary D-chiro-inositol (DCI) and L-chiro-inositol (LCI) both had a promoting effect on the increase in hepatic lipids due to DDT feeding. Dietary MI enhanced the hepatic free MI level and the phosphatidylinositol/phosphatidylcholine ratio, but dietary DCI reduced the level and ratio.
Okazaki
Yukako
Y
Department of Human Life Sciences Education, Graduate School of Education, Hiroshima University, Higashi-Hiroshima, Japan. yokazaki@fujijoshi.ac.jp
Setoguchi
Tomoyasu
T
Katayama
Tetsuyuki
T
D000821:Animal Feed; D000818:Animals; D003634:DDT / Q000494:pharmacology*; D007294:Inositol / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D008055:Lipids; D007294:Inositol; D003634:DDT