title: Four new macrocyclic trichothecenes from two strains of marine-derived fungi of the genus Myrothecium.
abstract: Three new macrocyclic trichothecenes, named 12'-hydroxyroridin E (1), roridin Q (2), and 2',3'deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13' position of 1. Compound 4 was a 2',3'-dihydro-2'-hydroxy derivative of roridin H. The IC50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 microM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 microg/disc (inhibition zone: 12.2 mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 microg/disc).
authors.affiliation: Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan.
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Xu
authors.forename: Azusa
authors.initials: A
authors.lastname: Takasaki
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Taiko
authors.initials: T
authors.lastname: Oda
authors.forename: Junko
authors.initials: J
authors.lastname: Yamada
authors.forename: Remy E P
authors.initials: RE
authors.lastname: Mangindaan
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Ukai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagai
authors.forename: Michio
authors.initials: M
authors.lastname: Namikoshi
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism*; D005658:Fungi; D047028:Macrocyclic Compounds / Q000494:pharmacology; D008386:Marine Biology; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009183:Mycotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C515285:12'-hydroxyroridin E; C515284:2',3'-deoxyroritoxin D; D000970:Antineoplastic Agents; D047028:Macrocyclic Compounds; D008387:Marine Toxins; D009183:Mycotoxins; D014255:Trichothecenes; C515283:roridin Q; C515282:roridin R