title: Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia.
abstract: Transient recovery (TR) of evoked synaptic potentials and ATP depletion during the late stage of hypoxic hypoglycemic insults were investigated in rat hippocampal slices. TR was observed not only in the late stage of insult, but also during recovery. The concentration of ATP corresponded to the appearance (27% of control) and disappearance (15% of control) of TR. Paired pulse studies showed the presynaptic nature of the release of inhibition of synaptic transmission during TR. Both N- and P/Q-type voltage-dependent calcium channels were involved in the appearance of TR. This evidence suggests that underlying mechanisms of TR appearance during hypoxic hypoglycemic insult might be related to ATP depletion and release of A1 adenosine receptor mediated inhibition of presynaptic voltage-dependent calcium channels.
authors.affiliation: Department of Neurosurgery, Korea University Guro Hospital, 80 Guro-dong, Guro-ku, Seoul 152-703, South Korea.
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Kim
authors.forename: Joo-Han
authors.initials: JH
authors.lastname: Kim
authors.forename: Kyung-Han
authors.initials: KH
authors.lastname: Kim
authors.forename: Taek-Hyun
authors.initials: TH
authors.lastname: Kwon
authors.forename: Youn-Kwan
authors.initials: YK
authors.lastname: Park
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004347:Drug Interactions; D004558:Electric Stimulation / Q000379:methods; D006624:Hippocampus / Q000503:physiopathology*; D007003:Hypoglycemia / Q000473:pathology*; D066298:In Vitro Techniques; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D008297:Male; D017729:Presynaptic Terminals / Q000187:drug effects / Q000502:physiology*; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D014970:Xanthines / Q000494:pharmacology; D020866:omega-Conotoxin GVIA / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D058915:Purinergic P1 Receptor Antagonists; D014970:Xanthines; D000255:Adenosine Triphosphate; D020866:omega-Conotoxin GVIA; C051360:1,3-dipropyl-8-cyclopentylxanthine