[The characteristics of proliferation activity in squamous metaplasia and reserve cell hyperplasia of uterine cervix].
The aim of our study was to investigate the characteristics of proliferation activity in squamous metaplasia and reserve cell hyperplasia of uterine cervix. Four groups of patients were selected: 1st group--34 reproductive patients with reserve cell hyperplasia, 2nd group--21 reproductive patients with squamous metaplasia, 3rd group--12 postmenopausal patients with reserve cell hyperplasia, 4th group--29 postmenopausal patients with squamous metaplasia. These groups included the patients with and without infections. Cervical biopsies were studied by immunohistochemistry using anti-Ki-67 monoclonal antibody. Ki-67(+) reserve cells were counted in reserve cell hyperplasia. Ki-67(+) squamous cells were counted in squamous metaplasia. The results showed that in both squamous metaplasia and reserve cell hyperplasia the number of Ki-67(+) cells, i.e. the intensity of proliferation is depended on the co-existence of infection, as well as on the age of the patient. These data are important in the complex treatment of cervical pseudoerosions.
Tsanava
R M
RM
Burkadze
G M
GM
Chkhobadze
M D
MD
Berdzenishvili
B R
BR
D000328:Adult; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000276:immunology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000276:immunology / Q000473:pathology; D019394:Ki-67 Antigen / Q000276:immunology; D008875:Middle Aged; D017698:Postmenopause; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000473:pathology*
D019394:Ki-67 Antigen