title: Modification of lymphocyte subsets in patients with rhinoscleroma.
abstract: OBJECTIVE
  Rhinoscleroma is a rare, chronic, granulomatous disorder of the upper airways. This disease presents some etiopathogenetic aspects that are not yet clear. Infection by Klebsiella rhinoscleromatis is fundamental for the onset of the disease, but it is impossible to reproduce rhinoscleroma experimentally only via infection with the bacteria both in man and in animals. Furthermore, this disease mainly affects blood-related people and occurs in certain geographic areas. In this context, we present a study that brings to light some of the quantitative abnormalities of the lymphocyte subsets.
  
  
  METHODS
  The study group consisted of 5 patients with rhinoscleroma. The following parameters were studied for each patient: clinical manifestations, histologic examinations, number of leukocytes, lymphocytes, and lymphocyte subsets.
  
  
  RESULTS
  In all patients, we noted the following: There was a relative reduction of the CD4+ cells, an absolute increase of the CD8+ cells, and an inversion of the CD4+/CD8+ ratio. There was an absolute increase of the CD56+ cells and cytotoxic cells that coexpress CD8+CD56+ antigens. There was a relative reduction of the CD3+ cells, and the CD19+ cells tended to show an ambiguous behavioral pattern.
  
  
  CONCLUSIONS
  We believe that K. rhinoscleromatis does not play a major role in the etiopathogenesis of rhinoscleroma. However, we do believe that the anomalous behavior of the immune system can favor rhinoscleroma.
authors.affiliation: Department of Otorhinolaryngology, Audiology and Phoniatrics Giorgio Ferreri, La Sapienza University of Rome, Rome, Italy. massimo.fusconi@libero.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Fusconi
authors.forename: Gianna
authors.initials: G
authors.lastname: Pulice
authors.forename: Flora
authors.initials: F
authors.lastname: Ippoliti
authors.forename: Romina
authors.initials: R
authors.lastname: Mastronicola
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ralli
authors.forename: Marco
authors.initials: M
authors.lastname: de Vincentiis
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000276:immunology*; D007711:Klebsiella pneumoniae; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012226:Rhinoscleroma / Q000276:immunology* / Q000382:microbiology
chemical_list: D015703:Antigens, CD