Modern aldol methods for the total synthesis of polyketides.
The aldol reaction is one of the most important methods for the stereoselective construction of polyketide natural products, not only for nature but also for synthetic chemistry. The tremendous development in the field of aldol additions during the last 30 years has led to more and more total syntheses of complicated natural products. This Review illustrates by means of selected syntheses of natural products the new variants of the aldol addition. This includes aldol additions with various metal enolates, as well as metal-complex-catalyzed, organocatalytic, and biocatalytic methods.
Schetter
Bernd
B
Chemisches Institut, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.
Mahrwald
Rainer
R
D000447:Aldehydes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001895:Boron / Q000737:chemistry; D002384:Catalysis; D004917:Erythromycin / Q000138:chemical synthesis; D018942:Macrolides / Q000138:chemical synthesis*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D018942:Macrolides; D009942:Organometallic Compounds; D004917:Erythromycin; C116609:3-hydroxybutanal; D001895:Boron