title: [Intracranial bleeding in acquired hemophilia].
abstract: Acquired hemophilia is a rare complication in autoimmune disorders and malignancies. It can result in bleedings into skin and muscle, whereas intracranial hemorrhage in adults has so far not been described. We report a patient with acute intracerebral hemorrhage due to acquired hemophilia with factor VIII inhibition. The patient was treated with recombinant factor VIIa and open hematoma evacuation followed by administration of cortisone and cyclophosphamide. After good initial recovery, intracerebral rebleeding occurred and the patient died from brainstem compression.
authors.affiliation: Neurologische Klinik, Klinikum Ludwigshafen, Ludwigshafen, Germany. lars.marquardt@clneuro.ox.ac.uk
authors.forename: L
authors.initials: L
authors.lastname: Marquardt
authors.forename: H
authors.initials: H
authors.lastname: Haubelt
authors.forename: S
authors.initials: S
authors.lastname: Gass
authors.forename: A J
authors.initials: AJ
authors.lastname: Grau
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D003131:Combined Modality Therapy; D003399:Craniotomy; D005167:Factor VII / Q000627:therapeutic use; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D015942:Factor VIIa; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D013702:Temporal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D011994:Recombinant Proteins; D005167:Factor VII; D005169:Factor VIII; C103587:recombinant FVIIa; D015942:Factor VIIa; D008775:Methylprednisolone