The acute effect of aerobic exercise on brachial artery endothelial function in renal transplant recipients.
This study compared the effect of a 30-minute walk on brachial artery endothelial vasodilatation in kidney transplant (KT) recipients and healthy controls (HCs). Endothelial-dependent vasodilatation was measured by ultrasound before and after exercise. The HCs experienced a significant increase in vasodilatation after exercise 1 minute postocclusion when compared with the KT recipients (22%+/-13% vs 3%+/-4%; P<.05). Also, the HCs had a significantly higher vasodilatation from pre-treadmill walk to post-treadmill walk (1 minute postocclusion) when compared with KT recipients (from 3%+/-6% to 22%+/-13% vs 1%+/-3% to 3%+/-4%; P<.05). This acute vasodilatory response observed in the HCs may be related to the immediate release of nitric oxide and the combined response to shear stress and exercise. The KT recipients had several coronary artery disease risk factors that may have adversely affected endothelial function.
Cosio-Lima
Ludmila M
LM
Division of Health, Leisure and Exercise Science, University of West Florida, Pensacola, FL 32514-5750, USA. lcosiolima@uwf.edu
Thompson
Paul D
PD
Reynolds
Katy L
KL
Headley
Samuel A
SA
Winter
Christa R
CR
Manos
Tina
T
Lagasse
Marie A
MA
Todorovich
John R
JR
Germain
Michael
M
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001916:Brachial Artery / Q000502:physiology*; D016022:Case-Control Studies; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000502:physiology*; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D014664:Vasodilation; D016138:Walking
D015415:Biomarkers