Anti-KEL7 (anti-Js(b)) alloimmunization diagnostic supported by molecular KEL*6,7 typing in a pregnant woman with previous intrauterine deaths.
Anti-KEL7 (anti-Js(b)) is a rare antibody that has been related to haemolytic transfusion reactions and HDN. We report a case of anti-KEL7 alloimmunization detected in a pregnant woman who had an obstetric previous history of four miscarriages and one stillborn. Employing classical immunohematological techniques, we studied the propositus and her available relatives. Due to the unavailability of commercial anti-KEL6 and anti-KEL7 reagents, we used a KEL*6,7 genotyping method as an alternative tool to contribute with the identification of the alloantibody origin. The results of KEL genotyping showed that the propositus was KEL*6/6 homozygous, while her second partner was KEL*7/7 homozygous.
Boturão-Neto
Edmir
E
Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu, 740, São Paulo 04023-092, SP, Brazil.
Chiba
Akemi Kuroda
AK
Oliveira Barros
Melca Maria
MM
Barretto de Mello
Adriana
A
Fabron
Antonio
A
Orlando Bordin
José
J
D000328:Adult; D001787:Blood Group Incompatibility / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D002675:Child, Preschool; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005313:Fetal Death / Q000235:genetics*; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood* / Q000235:genetics; D007626:Kell Blood-Group System / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology*; D018566:Pregnancy, High-Risk / Q000276:immunology; D065227:Transfusion Reaction
D007518:Isoantibodies; D007626:Kell Blood-Group System