Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation.
Francisella tularensis replicates in macrophages and dendritic cells, but interactions with other cell types have not been well described. F. tularensis LVS invaded and replicated within alveolar epithelial cell lines. Following intranasal inoculation of C57BL/6 mice, Francisella localized to the alveolus and replicated within alveolar type II epithelial cells.
Hall
Joshua D
JD
University of North Carolina, Chapel Hill, NC 27599-7290, USA.
Craven
Robin R
RR
Fuller
James R
JR
Pickles
Raymond J
RJ
Kawula
Thomas H
TH
D000818:Animals; D002460:Cell Line; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000382:microbiology*; D005604:Francisella tularensis / Q000254:growth & development*; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008856:Microscopy, Fluorescence; D011650:Pulmonary Alveoli / Q000166:cytology* / Q000382:microbiology*; D014406:Tularemia / Q000382:microbiology*