[Experimental study on the effect of tiangui gengnian capsule on the aged female rats ostepoprosis].
OBJECTIVE
To study the therapeutic action of Seabuckthorn Fatty Acid on the aged female rats osteoporosis, and explore the corresponding mechanism related in hormone and cytokine.


METHODS
The change of bone density (BMD), biomechanics and bone morphology were measured and E2, TGF-beta1, IGF-1 level in plasma were determined respectively for the young female rats, aged female rats (Seabuckthorn Fatty Acid 0.72, 1.8, 4.5 g/kg, E2 0.02 g/kg) after they were administrated corresponding drugs for 45 days.


RESULTS
The bone density (BMD), bone biomechanics, bone morphology for female rats aged 22-months all decreased. The BMD, bone biomechanics, the number of bone trabeculas and cortical thickness in Seabuckthorn Fatty Acid treated groups (1.8 g/kg, 4.5 g/kg) were upgraded (P < 0.05). The TGF-beta1, IGF-1 level in plasma were increased, too (P < 0.05).


CONCLUSIONS
Seabuckthorn Fatty Acid can meliorate bone metabolism in post-menopause and heighten the bone density. The adjustment mechanism may be based on the function of estrogen and cell cytokine.
Liu
Bo
B
Department of Pharmacology, Xi'an Jiaotong University, Xi'an 710061, China.
Yuan
Bing-Xiang
BX
Guo
Xiong
X
Wei
Xia-Zhen
XZ
Zhao
Li-Mei
LM
Chen
Dong
D
Kang
Jun
J
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005269:Femur / Q000378:metabolism / Q000648:ultrastructure; D031281:Hippophae / Q000737:chemistry*; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D010938:Plant Oils / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013131:Spine / Q000378:metabolism / Q000648:ultrastructure; D053773:Transforming Growth Factor beta1 / Q000097:blood
D002214:Capsules; D004365:Drugs, Chinese Herbal; D005231:Fatty Acids, Unsaturated; D010938:Plant Oils; D053773:Transforming Growth Factor beta1; D004958:Estradiol