Comparison of body fat distribution and blood lipid profiles according to Trp64Arg polymorphism for the beta 3-adrenergic receptor gene in Korean middle-aged women.
The aim of this study was to determine whether there was an association between body fat distribution, blood lipid profiles, and beta 3-adrenergic receptor gene polymorphism in Korean middle-aged women. Subjects were grouped according to BMI as obese (> or = 5 BMI, n = 95) or non-obese (BMI<25, n = 93). The Trp64Arg mutation of the beta 3-adrenergic receptor gene was detected by PCR-RFLP. Skinfold thickness, body circumference, intra-abdominal fat area by CT, and blood lipid profiles were also measured. Data were compared using ANOVA, Bonferroni t-test, and Chi-square. Significance for statistical analyses were set at p<0.05. In the obese group, 63.16% were Trp64Trp homozygotes and 36.84% were Trp64Arg heterozygotes, compared to 80.65% who were Trp64Trp homozygotes and 19.35% who were Trp64Arg heterozygotes in the non-obese group. These results indicated a significant (chi-square = 4.943, p<0.05) difference between the two groups. Frequency of the Arg64 allele in the obese group (16.84%) showed a significant (chi-square = 4.185, p<0.05) difference as compared to the non-obese group (9.68%). Skinfold thickness and body circumference of the Trp64Arg heterozygote group showed a consistent increase as compared to the Trp64Trp homozygote group. Visceral fat area and VSR of Trp64Arg heterozygote group showed a higher tendency than Trp64Trp homozygotes in the obese group, but these differences were not statistically significant. In conclusion, the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women.
Kim
Kijin
K
Department of Physical Education, Keimyung University, 1000, Shindang-dong, Dalseo-gu, Daegu, 704-701, Korea. kjk744@kmu.ac.kr
Lee
Seungno
S
Lee
Sunjang
S
Lim
Kiwon
K
Cheun
Wookwang
W
Ahn
Nayoung
N
Shin
Yoonjung
Y
Park
Jusik
J
Hong
Changbae
C
Kim
Sanghyun
S
D001120:Arginine / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis; D050218:Body Fat Distribution; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics; D007723:Korea; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000235:genetics; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012885:Skinfold Thickness; D014280:Triglycerides / Q000097:blood; D014364:Tryptophan / Q000235:genetics
D001786:Blood Glucose; D008076:Cholesterol, HDL; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D022702:Receptors, Adrenergic, beta-3; D014280:Triglycerides; D014364:Tryptophan; D001120:Arginine