Synthesis of the mycolactone core by ring-closing metathesis.
The undecenolide core of mycolactone was synthesized by ring-closing metathesis and the structure confirmed using single-crystal X-ray diffraction techniques.
Alexander
Matthew D
MD
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA.
Fontaine
Shaun D
SD
La Clair
James J
JJ
Dipasquale
Antonio G
AG
Rheingold
Arnold L
AL
Burkart
Michael D
MD
D001427:Bacterial Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
D001427:Bacterial Toxins; D018942:Macrolides; C117218:mycolactone