Comparison of GnRH antagonist cycles with and without oral contraceptive pretreatment in potential poor prognosis patients.
OBJECTIVE
To evaluate the effect of oral contraceptive pill (OCP) pretreatment in patients undergoing IVF cycles with an antagonist.


METHODS
In this retrospective study, 194 cycles of women with diminished ovarian reserve undergoing IVF with a protocol using GnRH antagonists were evaluated. Oral contraceptive pretreatment was used in 146 cycles.


RESULTS
Pregnancy rates were the same in both groups. Patients using OCPs required more gonadotropins (5,890 IU) compared to patients not undergoing OCP pretreatment (4,410 IU).


CONCLUSIONS
Pregnancy outcomes were the same whether or not OCP pretreatment was implemented in poor responders using an antagonist protocol. While OCP pretreatment may help with scheduling flexibility, the higher dose of gonadotropins needed for ovarian stimulation should be considered.
Bendikson
K
K
Department of Obstetrics and Gynecology, Stanford University School of Medicine, CA 94305, USA.
Milki
A A
AA
Speck-Zulak
A
A
Westphal
L M
LM
D000328:Adult; D002140:California; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome
D003276:Contraceptives, Oral; D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone