title: Association study of the tumor necrosis factor-alpha gene and its 1A receptor gene with methamphetamine dependence.
abstract: Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-alpha (TNF-alpha) mRNA in some brain regions and that TNF-alpha blocked METH neurotoxicity and rewarding effects suggest TNF-alpha, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-alpha gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-alpha gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-alpha or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-alpha gene and its receptor genes may not be involved in individual vulnerability to METH dependence.
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nomura
authors.forename: H
authors.initials: H
authors.lastname: Ujike
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Kishimoto
authors.forename: K
authors.initials: K
authors.lastname: Otani
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
authors.forename: A
authors.initials: A
authors.lastname: Morio
authors.forename: M
authors.initials: M
authors.lastname: Harano
authors.forename: T
authors.initials: T
authors.lastname: Inada
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Komiyama
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: Y
authors.initials: Y
authors.lastname: Sekine
authors.forename: N
authors.initials: N
authors.lastname: Iwata
authors.forename: I
authors.initials: I
authors.lastname: Sora
authors.forename: M
authors.initials: M
authors.lastname: Iyo
authors.forename: N
authors.initials: N
authors.lastname: Ozaki
authors.forename: S
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000235:genetics*; D016022:Case-Control Studies; D015259:Dopamine Agents / Q000494:pharmacology*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D015259:Dopamine Agents; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha; D008694:Methamphetamine