Decreased lipid peroxidation following periodontal therapy in type 2 diabetic patients.
BACKGROUND
Although diabetes mellitus and periodontal disease promote atherosclerosis, the relation of oxidative stress with these diseases remains unclear. To investigate the influence of periodontal disease on oxidative stress, we assessed the effects of initial periodontal therapy on lipid peroxide (LPO), an oxidative stress index, in type 2 diabetic and non-diabetic patients.


METHODS
Seventeen subjects with or without type 2 diabetes were enrolled in this intervention study. No patient had a history of cardiovascular or peripheral vascular disease. Five type 2 diabetic and six non-diabetic patients, all with moderate to severe periodontal disease, received and completed the initial periodontal therapy and examination. Before and after the therapy, patients underwent medical examinations and blood determinations, including LPO.


RESULTS
Before the therapy, the periodontal probing depth and bleeding on probing (BOP) were similar between groups. LPO, triglyceride, and white blood cell counts were significantly higher in diabetic than non-diabetic patients. Therapy improved the periodontal parameters in both groups and significantly decreased LPO in diabetic patients. Anti-malondialdehyde-modified low-density lipoprotein (MDA-LDL) antibody, a marker of oxidized LDL, significantly decreased with treatment in both groups. Overall, Spearman rank correlation showed no significance between periodontal parameters and LPO or anti-MDA-LDL antibody, but BOP tended to correlate with LPO in diabetic patients (r = 0.585; P = 0.0791).


CONCLUSIONS
Although this is a small and preliminary study, and the changes of LPO and anti-MDA-LDL antibody were within the normal range, the initial periodontal therapy significantly decreased LPO, an oxidative stress index, in type 2 diabetic patients with periodontal disease.
Sonoki
Kazuo
K
Division of General Internal Medicine, Department of Health Promotion, Science of Health Improvement, Kyushu Dental College, Kitakyushu, Japan. sonoki@kyu-dent.ac.jp
Nakashima
Sayori
S
Takata
Yutaka
Y
Naito
Toru
T
Fujisawa
Kiyoshi
K
Ootsubo
Toshio
T
Wakisaka
Masanori
M
Iwase
Masanori
M
Iida
Mitsuo
M
Yokota
Makoto
M
D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010510:Periodontal Diseases / Q000150:complications* / Q000378:metabolism* / Q000628:therapy; D010512:Periodontal Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein