title: Rapidly enlarging chordoid meningioma with abundant mucin production.
abstract: This 77-year-old woman with a rapidly enlarging chordoid meningioma first noticed a growing, non-pulsatile, nonpainful soft mass in the left temporal region after a head trauma 2 years earlier. Neuroimaging showed a homogeneously enhanced osteolytic mass lesion in the left temporal bone. Surgery revealed an extradural tumor without significant adhesions. Histopathologically it was a meningioma with features reminiscent of chordoma. Most of the tumor cells contained mucin-rich chordoid elements. Immunohistochemically, the lesion was positive for vimentin and epithelial membranous antigen; it was negative for cytokeratin and S-100 protein. Based on these findings a diagnosis of chordoid meningioma was made. We posit that the rapid enlargement of the tumor over a relatively short period was attributable to its high mucin-producing activity.
authors.affiliation: Department of Neurosurgery, Kumamoto University School of Medicine, 1-1-1, Honjo, Kumamoto 860-8556, Japan. shasegawa@fc.kuh.kumamoto-u.ac.jp
authors.forename: Shu
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Susumu
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Shougo
authors.initials: S
authors.lastname: Urabe
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kuratsu
mesh_terms: D000368:Aged; D002817:Chordoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009077:Mucins / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D009077:Mucins