Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.
Nasongkla
Norased
N
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Bey
Erik
E
Ren
Jimin
J
Ai
Hua
H
Khemtong
Chalermchai
C
Guthi
Jagadeesh Setti
JS
Chin
Shook-Fong
SF
Sherry
A Dean
AD
Boothman
David A
DA
Gao
Jinming
J
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000737:chemistry; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D039302:Integrin alphaVbeta3 / Q000737:chemistry; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship; D013499:Surface Properties
D005290:Ferric Compounds; D039302:Integrin alphaVbeta3; D008024:Ligands; D008823:Micelles; D009842:Oligopeptides; D011108:Polymers; C000499:ferric oxide; C047981:arginyl-glycyl-aspartic acid; D004317:Doxorubicin