title: [Effects of jianwei yuyang granule on inflammatory reaction and NF-kappaB expression in rat gastric mucosa of ulcer healing and recurrence].
abstract: OBJECTIVE
  To observe the effects of Jianwei Yuyang granule (JWYY) on inflammatory reaction and NF-kappaB expression in rat gastric mucosa of ulcer healing and recurrence.
  
  
  METHODS
  Gastric ulcer was induced in rat by acetic acid according Okeba's method with some modification and the recurrence model was induced by IL-1beta. Pathohistology of ulcer healing and recurrence was observed. Density of inflammatory cell infiltrating regenerative mucosa, NF-kappaB protein and mRNA expression were measured.
  
  
  RESULTS
  JWYY had effects on improving the quality of ulcer healing, reducing the rate of ulcer recurrence, decreasing the density of inflammatory cell infiltrating regenerative mucosa and suppressing the activation and expression quantity of NF-kappaB protein and mRNA.
  
  
  CONCLUSIONS
  JWYY may promote the ulcer healing and prevent the recurrence of the gastric ulcer by suppressing the activation of NF-kappaB and the following inflammatory reaction.
authors.affiliation: Traditional Chinese Medicine Department, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China. ling_jianghong@sina.com
authors.forename: Jiang-Hong
authors.initials: JH
authors.lastname: Ling
authors.forename: Ye-Qiang
authors.initials: YQ
authors.lastname: Chen
authors.forename: Jia-Bang
authors.initials: JB
authors.lastname: Li
authors.forename: Yu-Zheng
authors.initials: YZ
authors.lastname: Pan
authors.forename: Yang
authors.initials: Y
authors.lastname: Cao
authors.forename: Ding-Zhu
authors.initials: DZ
authors.lastname: Shen
mesh_terms: D019342:Acetic Acid; D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D016328:NF-kappa B / Q000096:biosynthesis* / Q000235:genetics; D010946:Plants, Medicinal / Q000737:chemistry; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; D012333:RNA, Messenger; D019342:Acetic Acid