title: [Comparative chemical proteomics: simultaneous identification of disease-specific protein targets and their small molecule-binding partners, suitable as drug candidates].
abstract: The simultaneous identification of disease-specific protein targets and their small molecule binding partners, suitable as drug candidates, could radically reduce the timeline and costs of drug discovery and development. Comparative chemical proteomics provides a novel approach to achieve this goal through rapid detection of overexpressed proteins in diseased samples by the application of small molecule microarrays. The interacting small molecules enables direct affinity-based isolation and identification of the proteins. In the present paper we report comparative chemical proteomics studies on melanocytes and melanoma cell-lines, which led to the identification of 3 overexpressed proteins (e.g. -tubulin) together with their small molecule binding partner.
authors.affiliation: ComGenex, Budapest, Záhony.
authors.forename: György
authors.initials: G
authors.lastname: Dormán
authors.forename: László G
authors.initials: LG
authors.lastname: Puskás
authors.forename: Liliána Z
authors.initials: LZ
authors.lastname: Fehér
authors.forename: László
authors.initials: L
authors.lastname: Hackler
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Lorincz
authors.forename: Csaba
authors.initials: C
authors.lastname: Lang
authors.forename: László
authors.initials: L
authors.lastname: Urge
authors.forename: Ferenc
authors.initials: F
authors.lastname: Darvas
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D002460:Cell Line; D045744:Cell Line, Tumor; D002625:Chemistry, Organic / Q000379:methods; D006801:Humans; D008544:Melanocytes; D008545:Melanoma; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D040901:Proteomics; D014404:Tubulin / Q000235:genetics / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D009363:Neoplasm Proteins; D011506:Proteins; D014404:Tubulin