title: Rapid systemic bone resorption during the course of Staphylococcus aureus-induced arthritis.
abstract: Bacterial arthritis is the most rapidly progressing destructive joint disease in humans. To evaluate bone resorption and formation, mice were injected with Staphylococcus aureus and killed after 3 and 14 days. Both total and trabecular bone mineral density were, compared with those in uninfected controls, already significantly reduced 3 days after bacterial inoculation. Serum levels of type I collagen fragments were significantly increased and osteocalcin levels decreased in mice infected with S. aureus, compared with those in noninfected mice, 3 and 14 days after bacterial inoculation. This study shows that there is a rapid and easily measurable systemic bone resorption during S. aureus-induced arthritis.
authors.affiliation: Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, S-41346 Goteborg, Sweden. margareta.verdrengh@rheuma.gu.se
authors.forename: Margareta
authors.initials: M
authors.lastname: Verdrengh
authors.forename: Hans
authors.initials: H
authors.lastname: Carlsten
authors.forename: Claes
authors.initials: C
authors.lastname: Ohlsson
authors.forename: Andrej
authors.initials: A
authors.lastname: Tarkowski
mesh_terms: D000818:Animals; D001170:Arthritis, Infectious / Q000150:complications* / Q000382:microbiology*; D015519:Bone Density; D001862:Bone Resorption / Q000209:etiology*; D024042:Collagen Type I / Q000097:blood; D051379:Mice; D015675:Osteocalcin / Q000097:blood; D013203:Staphylococcal Infections / Q000150:complications* / Q000382:microbiology*; D013211:Staphylococcus aureus
chemical_list: D024042:Collagen Type I; D015675:Osteocalcin