title: Tractor_DB (version 2.0): a database of regulatory interactions in gamma-proteobacterial genomes.
abstract: The version 2.0 of Tractor_DB is now accessible at its three international mirrors: www.bioinfo.cu/Tractor_DB, www.tractor.lncc.br and http://www.ccg.unam.mx/tractorDB. This database contains a collection of computationally predicted Transcription Factors' binding sites in gamma-proteobacterial genomes. These data should aid researchers in the design of microarray experiments and the interpretation of their results. They should also facilitate studies of Comparative Genomics of the regulatory networks of this group of organisms. In this paper we describe the main improvements incorporated to the database in the past year and a half which include incorporating information on the regulatory networks of 13-increasing to 30-new gamma-proteobacteria and developing a new computational strategy to complement the putative sites identified by the original weight matrix-based approach. We have also added dynamically generated navigation tabs to the navigation interfaces. Moreover, we developed a new interface that allows users to directly retrieve information on the conservation of regulatory interactions in the 30 genomes included in the database by navigating a map that represents a core of the known Escherichia coli regulatory network.
authors.affiliation: National Bioinformatics Center, Cuba.
authors.forename: Abel González
authors.initials: AG
authors.lastname: Pérez
authors.forename: Vladimir Espinosa
authors.initials: VE
authors.lastname: Angarica
authors.forename: Ana Tereza R
authors.initials: AT
authors.lastname: Vasconcelos
authors.forename: Julio
authors.initials: J
authors.lastname: Collado-Vides
mesh_terms: D001665:Binding Sites; D019295:Computational Biology; D030561:Databases, Nucleic Acid; D004926:Escherichia coli / Q000235:genetics; D020563:Gammaproteobacteria / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D023281:Genomics; D020407:Internet; D050436:Regulatory Elements, Transcriptional; D014157:Transcription Factors / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D014157:Transcription Factors