Role of DHEA and growth factors in chromaffin cell proliferation.
Dehydroepiandrostreone (DHEA) is a neuroactive steroid produced by the inner layer of the adrenal cortex close to the adrenomedullary cells. Chromaffin cell growth and proliferation are under the control of insulin-like growth factor II (IGF-II) and basic fibroblast growth factor (bFGF). The aim of the present study was to examine the role of DHEA on chromaffin cell proliferation induced by IGF-II and bFGF. In our model, DHEA significantly decreased IGF-II-induced proliferation by 48.7%, whereas it did not affect the proliferation induced by bFGF. These data suggest that DHEA exerts a paracrine function in the control of chromaffin cell growth.
Sicard
F
F
Department of Medicine, Carl Gustav Carus University Hospital, Medical Clinic III, University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
Krug
A W
AW
Ziegler
C G
CG
Sperber
S
S
Ehrhart-Bornstein
M
M
Bornstein
S R
SR
D049109:Cell Proliferation / Q000187:drug effects*; D019439:Chromaffin Cells / Q000166:cytology / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000494:pharmacology*
D016222:Fibroblast Growth Factor 2; D003687:Dehydroepiandrosterone; D007335:Insulin-Like Growth Factor II