title: Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
abstract: In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.
authors.affiliation: Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
authors.forename: Winnie S
authors.initials: WS
authors.lastname: Liang
authors.forename: Travis
authors.initials: T
authors.lastname: Dunckley
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Beach
authors.forename: Andrew
authors.initials: A
authors.lastname: Grover
authors.forename: Diego
authors.initials: D
authors.lastname: Mastroeni
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Walker
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Caselli
authors.forename: Walter A
authors.initials: WA
authors.lastname: Kukull
authors.forename: Daniel
authors.initials: D
authors.lastname: McKeel
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.forename: Christine
authors.initials: C
authors.lastname: Hulette
authors.forename: Donald
authors.initials: D
authors.lastname: Schmechel
authors.forename: Gene E
authors.initials: GE
authors.lastname: Alexander
authors.forename: Eric M
authors.initials: EM
authors.lastname: Reiman
authors.forename: Joseph
authors.initials: J
authors.lastname: Rogers
authors.forename: Dietrich A
authors.initials: DA
authors.lastname: Stephan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D012313:RNA