Changes of hippocampal protein levels during postnatal brain development in the rat.
Information on postnatal brain protein expression is very limited, and we therefore compared hippocampal protein levels in rat hippocampus at different developmental time points using two-dimensional gel electrophoresis followed by mass spectrometrical protein identification and specific software for quantification. Proteins from several cascades as e.g., antioxidant, metabolic, cytoskeleton, proteasomal, and chaperone pathways were developmentally regulated, which is relevant for design and interpretation of protein chemical studies in the mammalian brain.
Weitzdörfer
Rachel
R
Medical University of Vienna, Department of Neonatology, Vienna, Austria.
Höger
Harald
H
Pollak
Arnold
A
Lubec
Gert
G
D000375:Aging; D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005260:Female; D006624:Hippocampus / Q000254:growth & development*; D009419:Nerve Tissue Proteins / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
D009419:Nerve Tissue Proteins