Polypharmacy in oligopopulations: what psychiatric genetics can teach biological psychiatry.
Psychiatric genetics and genomics have made major strides in recent years. Some of that knowledge has yet to permeate in the clinical practice of biological psychiatry. The example of cancer-genetics, biology and clinical treatments may be profitable in terms of accelerating translational integration in psychiatry. We propose that current developments in genetics and genomics point to an Early Low-Dose Rational Polypharmacy in Oligopopulations model for psychiatric pharmacotherapy.
Niculescu
Alexander B
AB
Laboratory of Neurophenomics, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. anicules@iupui.edu
D004347:Drug Interactions; D005824:Genetics, Behavioral; D006801:Humans; D019338:Polypharmacy