title: What happens now? Ongoing outcome after post-temporal lobectomy seizure recurrence.
abstract: We studied outcome subsequent to the initial post-temporal lobectomy seizure recurrence (n = 202) or remission. Two years after recurrence, there was 74% (95% CI 67% to 79%) probability of further seizures. Two years after a 2-year seizure remission, there was 68% (95% CI 52% to 79%) probability of remaining seizure-free (n = 50). Remission after seizures had a significantly poorer outcome than an equivalent period of complete seizure freedom after surgery. Implications for outcome classification are discussed.
authors.affiliation: Epilepsy Research Centre, School of Nursing, Department of Medicine, University of Melbourne, Victoria, Australia. a.mcintosh@unimelb.edu.au
authors.forename: Anne M
authors.initials: AM
authors.lastname: McIntosh
authors.forename: Samuel F
authors.initials: SF
authors.lastname: Berkovic
mesh_terms: D004827:Epilepsy / Q000453:epidemiology* / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000706:statistics & numerical data*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D055502:Secondary Prevention; D013702:Temporal Lobe / Q000503:physiopathology* / Q000601:surgery*; D013995:Time; D013997:Time Factors; D016896:Treatment Outcome