Template-assisted synthesis of nanogels from Pluronic-modified poly(acrylic acid).
A series of novel polymeric nanogels with core-shell morphology was developed. Block ionomer complexes of comb-graft poly(ethylene oxide)-b-poly(polypropylene oxide)-b-poly(ethylene oxide)-g-poly(acrylic acid) copolymers (Pluronic-PAA) and divalent metal cations were utilized as micellar templates for the synthesis of nanogels with sizes ranging from 100 to 200 nm in diameter. The Pluronic-PAA nanogels were confirmed to possess ionic cross-linked PAA cores and flexible hydrophilic shells from the Pluronic copolymer chains. The ionic character of the core provided for pH-dependent swelling/collapse behavior of the nanogels. These prepared nanogels are expected to be of utility as carriers for charged therapeutic or diagnostic agents.
Bronich
Tatiana K
TK
Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. tbronich@unmc.edu
Bontha
Satya
S
Shlyakhtenko
Luda S
LS
Bromberg
Lev
L
Hatton
T Alan
TA
Kabanov
Alexander V
AV
D000179:Acrylates / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry; D003102:Colloids / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004492:Edetic Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D018625:Microscopy, Atomic Force; D008962:Models, Theoretical; D000080385:Nanogels; D053758:Nanoparticles / Q000737:chemistry; D009391:Nephelometry and Turbidimetry / Q000379:methods; D009994:Osmolar Concentration; D020442:Poloxamer / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D011094:Polyethyleneimine / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
D000179:Acrylates; D003102:Colloids; D003432:Cross-Linking Reagents; D008823:Micelles; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; D020442:Poloxamer; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D004492:Edetic Acid; C036658:acrylic acid; D002122:Calcium Chloride