title: Quantitative modeling of laser speckle imaging.
abstract: We have analyzed the image formation and dynamic properties in laser speckle imaging (LSI) both experimentally and with Monte Carlo simulation. We show for the case of a liquid inclusion that the spatial resolution and the signal itself are both significantly affected by scattering from the turbid environment. Multiple scattering leads to blurring of the dynamic inhomogeneity as detected by LSI. The presence of a nonfluctuating component of scattered light results in the significant increase in the measured image contrast and complicates the estimation of the relaxation time. We present a refined processing scheme that allows a correct estimation of the relaxation time from LSI data.
authors.affiliation: Department of Physics, University of Fribourg, Fribourg, Switzerland. Pavel.Zakharov@unifr.ch
authors.forename: Pavel
authors.initials: P
authors.lastname: Zakharov
authors.forename: Andreas
authors.initials: A
authors.lastname: Völker
authors.forename: Alfred
authors.initials: A
authors.lastname: Buck
authors.forename: Bruno
authors.initials: B
authors.lastname: Weber
authors.forename: Frank
authors.initials: F
authors.lastname: Scheffold
mesh_terms: D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007834:Lasers; D008027:Light; D008956:Models, Chemical; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D012031:Refractometry / Q000379:methods*; D012542:Scattering, Radiation