Synthesis, characterization, and in vivo skeletal localization of a new (99m)Tc-based multidentate phosphonate chelate: 5-Amino-1,3-bis(ethylamine-(N,N dimethyl diphosphonic acid) acetamido) benzene.
The tetraphosphonate ligand, 5-amino-1,3-bis(ethylamine-(N,N-dimethyl diphosphonic acid) acetamido) benzene (IPTMP) used in the present study was prepared from 5-nitroisophthalate dimethylester to label with radionuclide for targeted diagnosis and therapy. The synthesized multidentate phosphonate ligand was characterized on the basis of spectroscopic techniques, which exhibited good metal ion control properties when complexed to (99m)Tc with high in vitro and in vivo stability. Excellent quality bone images of rabbit were imaged showing rapid clearance of background activity and visualization of skeleton at 1h.
Panwar
Puja
P
Division of cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Road, Delhi 110054, India.
Singh
Sweta
S
Kumar
Nitin
N
Rawat
Harish
H
Mishra
Anil K
AK
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002614:Chelating Agents / Q000138:chemical synthesis; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008807:Mice, Inbred BALB C; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000633:toxicity; D004369:Pentetic Acid / Q000494:pharmacology; D049268:Positron-Emission Tomography; D011786:Quality Control; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013669:Technetium Tc 99m Medronate; D014018:Tissue Distribution
C517842:(99m)Tc 5-Amino-1,3-bis(ethylamine-(N,N dimethyl diphosphonic acid) acetamido) benzene; D002614:Chelating Agents; D007202:Indicators and Reagents; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D004369:Pentetic Acid; D013669:Technetium Tc 99m Medronate