Prevalent genotypes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) in spontaneously aborted embryos.
OBJECTIVE
To assess prevalent 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms in spontaneously aborted embryos.


METHODS
A retrospectively analyzed, prospectively obtained database.


METHODS
Bundang CHA General Hospital and Kangnam CHA Hospital.


METHODS
Ninety-four spontaneously aborted embryos at <20 weeks of gestational age.


METHODS
None.


METHODS
Genotype frequency of MTHFR C677T and A1298C polymorphisms in spontaneously aborted embryos.


RESULTS
The aborted embryos exhibited both a significantly high frequency of the MTHFR 677CC genotype and a low frequency of the MTHFR 677CT genotype, compared to both the child and the adult control groups, respectively, whereas no significant change in the fetal MTHFR A1298C genotype frequency was observed. The combinative genotype of MTHFR 677CC/1298AC from the abortus had a high prevalence compared to the child controls. Further, the chromosomal integrity of the abortus did not affect the frequency of the MTHFR 677CC and 1298AC genotypes.


CONCLUSIONS
Spontaneously aborted embryos have a unique distribution of MTHFR C677T and A1289C polymorphisms, regardless of their chromosomal integrity.
Bae
Jeehyeon
J
Institute for Clinical Research, Bundang CHA General Hospital, College of Medicine, Seongnam, South Korea.
Shin
Seung Joo
SJ
Cha
Sun Hee
SH
Choi
Dong Hee
DH
Lee
Suman
S
Kim
Nam Keun
NK
D000022:Abortion, Spontaneous / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics*; D004252:DNA Mutational Analysis; D004622:Embryo, Mammalian / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
D042965:Methylenetetrahydrofolate Reductase (NADPH2)