[Early stages of CD34+ differentiation during radiation exposure].
The author relatively separated and described early stages of the differentiation CD34+ cells population in patients exposed to radiation. It was done based on functional criterion which reflects ability of cells to express membrane antigens (receptors). These antigens may be revealed through monoclonal antigens. Obtained data indicate the CD34+ cells population to be instable after long period of time the patients were exposed to radiation and radionuclides incorporated into the bodies of these patients. Consequent activation of some chains of unified cascade process of cells development was noted. It has led to progressive proliferation of progenitor cells with some kind of retardation of their differentiation. Revealed changes could be treated as a result of modification at the early stages of hematopoietic stem cells and progenitor cells differentiation and it may be considered as cellular reaction activated by radiation.
Bieliaieva
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D000911:Antibodies, Monoclonal; D018952:Antigens, CD34 / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology / Q000528:radiation effects*; D002462:Cell Membrane / Q000276:immunology / Q000528:radiation effects; D047852:Chernobyl Nuclear Accident; D006801:Humans; D016130:Immunophenotyping; D008564:Membrane Potentials / Q000276:immunology / Q000528:radiation effects; D009784:Occupational Diseases / Q000097:blood / Q000276:immunology / Q000473:pathology*; D011832:Radiation Injuries / Q000097:blood / Q000276:immunology / Q000473:pathology*; D011839:Radiation, Ionizing; D013234:Stem Cells / Q000276:immunology / Q000502:physiology / Q000528:radiation effects*; D014455:Ukraine
D000911:Antibodies, Monoclonal; D018952:Antigens, CD34