Anti-inflammatory effect of bioflora probiotic administered orally or subcutaneously with live or dead bacteria.
The anti-inflammatory effect of Bioflora probiotic administered orally or subcutaneously with viable or nonviable bacteria was analyzed in two experimental models of randomly selected female Wistar rats. The use of indomethacin at a dose of 50 mg/kg was associated with gastric necrotic lesions and multiple erosions of the small intestine, with marked mucosal neutrophil infiltrate measured by myeloperoxidase (MPO). Probiotics prevented both gastrointestinal lesions and neutrophil infiltrate (p < 0.001). In the model of carrageenin-induced plantar edema in the rat, the oral or subcutaneous administration of Bioflora with live or dead bacteria proved to prevent plantar edema (p < 0.001). We concluded that Bioflora probiotic given orally or subcutaneously with live or dead bacteria has an anti-inflammatory effect.
Laudanno
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Experimental Gastroenterology, School of Medical Sciences, Cochabamba 2090, 2000, Rosario, Argentina. olaudano@hotmail.com
Vasconcelos
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Catalana
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Cesolari
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D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001644:Bifidobacterium / Q000502:physiology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D013293:Enterococcus faecalis / Q000502:physiology; D005260:Female; D005534:Foot Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000382:microbiology / Q000503:physiopathology / Q000517:prevention & control*; D007213:Indomethacin; D007279:Injections, Subcutaneous; D007780:Lacticaseibacillus casei / Q000502:physiology; D048191:Lactiplantibacillus plantarum / Q000502:physiology; D050296:Microbial Viability; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D007213:Indomethacin