Natural antisense transcripts of Alzheimer's disease associated genes.
Natural antisense transcripts (NATs), also named endogenous antisense transcripts, are a class of genes whose role in controlling gene expression is becoming more and more relevant. NATs might play important roles in gene expression and translation regulation. Present work investigated the presence of NATs of Alzheimer's disease associated genes including PRESENILIN1, PRESENILIN2, BACE1, BACE2, APP, APOE, TAU (MAPT), PRION, alpha-SYNUCLEIN (SNCA), NICASTRIN, PEN2, APH1A, APH1B as well as CD147 (BASIGIN), and the results revealed that APP, BACE2, APH1A, TAU, CD147 and alpha-SYNUCLEIN contain natural antisense transcripts. These NATs were characterized according to the sense-antisense overlapping information and potential functional mechanisms were proposed. Present findings provide preliminary but important information about transcription regulation of AD associated genes, which would further our understanding of the gene expression regulation of AD, and also suggest a novel potential strategy for the therapy of AD.
Guo
Jin-Hu
JH
Neurology, Pharmacology and Physiology Department, University of Chicago, Chicago, IL 60637, USA. jinhu.guo@utsouthwestern.edu
Cheng
Hai-Peng
HP
Yu
Long
L
Zhao
Shouyuan
S
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D053829:Amyloid Precursor Protein Secretases / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D016282:Aspartic Acid Endopeptidases / Q000235:genetics; D001483:Base Sequence; D051926:Basigin / Q000235:genetics; D010450:Endopeptidases; D005786:Gene Expression Regulation; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000235:genetics; D034622:RNA Interference; D016372:RNA, Antisense / Q000032:analysis*; D014158:Transcription, Genetic; D051844:alpha-Synuclein / Q000235:genetics; D016875:tau Proteins / Q000235:genetics
D016564:Amyloid beta-Protein Precursor; C054369:MAPT protein, human; D008565:Membrane Proteins; D016372:RNA, Antisense; D051844:alpha-Synuclein; D016875:tau Proteins; D051926:Basigin; C475154:APH1A protein, human; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D010447:Peptide Hydrolases; D016282:Aspartic Acid Endopeptidases; C509284:BACE2 protein, human