title: [Experimental study on the effect of tiangui gengnian capsule on the aged female rats ostepoprosis].
abstract: OBJECTIVE
  To study the therapeutic action of Seabuckthorn Fatty Acid on the aged female rats osteoporosis, and explore the corresponding mechanism related in hormone and cytokine.
  
  
  METHODS
  The change of bone density (BMD), biomechanics and bone morphology were measured and E2, TGF-beta1, IGF-1 level in plasma were determined respectively for the young female rats, aged female rats (Seabuckthorn Fatty Acid 0.72, 1.8, 4.5 g/kg, E2 0.02 g/kg) after they were administrated corresponding drugs for 45 days.
  
  
  RESULTS
  The bone density (BMD), bone biomechanics, bone morphology for female rats aged 22-months all decreased. The BMD, bone biomechanics, the number of bone trabeculas and cortical thickness in Seabuckthorn Fatty Acid treated groups (1.8 g/kg, 4.5 g/kg) were upgraded (P < 0.05). The TGF-beta1, IGF-1 level in plasma were increased, too (P < 0.05).
  
  
  CONCLUSIONS
  Seabuckthorn Fatty Acid can meliorate bone metabolism in post-menopause and heighten the bone density. The adjustment mechanism may be based on the function of estrogen and cell cytokine.
authors.affiliation: Department of Pharmacology, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Bing-Xiang
authors.initials: BX
authors.lastname: Yuan
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
authors.forename: Xia-Zhen
authors.initials: XZ
authors.lastname: Wei
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Zhao
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Kang
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005269:Femur / Q000378:metabolism / Q000648:ultrastructure; D031281:Hippophae / Q000737:chemistry*; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D010938:Plant Oils / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013131:Spine / Q000378:metabolism / Q000648:ultrastructure; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D005231:Fatty Acids, Unsaturated; D010938:Plant Oils; D053773:Transforming Growth Factor beta1; D004958:Estradiol