Incidence rates of the major leukemia subtypes among US Hispanics, Blacks, and non-Hispanic Whites.
While leukemia rates are thought to be lower in South and Central America, no study has systematically investigated incidence rates of the leukemia subtypes among Hispanics in the U.S. This was a retrospective cohort study, using data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute, 1992 - 2001, to compare leukemia incidence rates as a function of race and ethnicity. It was found that in adults, Hispanics had lower incidence rates for each of the major types of leukemia as compared to non-Hispanic Whites: For AML, elderly Whites had an incidence rate ratio (IRR) of 1.61 in comparison to Hispanics (p < 0.001) and 1.27 in comparison to Blacks (p < 0.001); for CML, the IRR among the elderly was 1.42 that of Hispanics (p < 0.001) and 1.22 that of Blacks (p = 0.003); and for CLL, the IRR was 2.31 times that of Hispanics (p < 0.001) and 1.48 times that of Blacks (p < 0.001). In ALL, however, Hispanics aged 0 - 19 had a significantly higher incidence rate than Whites and Blacks, with an IRR of 1.32 compared to Whites (p < 0.001), and 2.62 compared to Blacks (p < 0.001). In AML, CML, and CLL, among people age 65 or older, white non-Hispanics have higher incidence rates than Blacks, and Blacks have higher incidence rates than Hispanics. Childhood ALL incidence rates are highest among Hispanics, and lowest among Blacks.
Matasar
Matthew J
MJ
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Ritchie
Ellen K
EK
Consedine
Nathan
N
Magai
Carol
C
Neugut
Alfred I
AI
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People / Q000208:ethnology; D002648:Child; D002675:Child, Preschool; D006630:Hispanic or Latino / Q000208:ethnology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000145:classification* / Q000453:epidemiology*; D008875:Middle Aged; D044465:White People / Q000208:ethnology