The hypolipidaemic activity of aqueous Erica multiflora flowers extract in Triton WR-1339 induced hyperlipidaemic rats: a comparison with fenofibrate.
In the present study, an aqueous extract from Erica multiflora L. (Ericaceae) flowers was evaluated for its hypocholesterolaemic and hypotriglyceridaemic activities using Triton WR-1339 induced hyperlipemic rats as experimental model. Hyperlipideamia was developed by intraperitonial injection of Triton (200mg/kg body weight). The animals were divided into control (CG), hyperlipidaemic (HG), hyperlipidaemic plus herb extract (HG+EmE) and hyperlipidaemic plus fenofibrate (HG+FF) treated groups. Intragastric administration of Erica multiflora extract (0.25 g/100g body weight) to the rats caused a significant decrease on their plasma lipid levels (quantified using enzymatic kits). At 7h after treatment, plasma total cholesterol, triglycerides and LDL-cholesterol were decreased by 47%, 95% and 67%, respectively, but the change of HDL-cholesterol level was not significant. However, the hypolipidaemic effect of fenofibrate was limited to triglycerides and LDL-cholesterol, which were lowered by about 92% and 41%, respectively. At 24h after treatment, Erica multiflora extract reduced plasma total cholesterol by 68.5% and triglycerides by 91%. HDL-cholesterol was not significantly increased and LDL-cholesterol was lowered by 80.5%. In fenofibrate treated rats, only plasma triglyceride concentrations were lowered by 82%, while the other lipid parameters were not significantly changed indicating that this aqueous herb extract may contain products that lower plasma lipid concentrations and might be beneficial in treatment of hyperlipideamia.
Harnafi
Hicham
H
Laboratoire de Biochimie, Faculty of Sciences, Oujda, Morocco.
Bouanani
Nour El Houda
Nel H
Aziz
Mohammed
M
Serghini Caid
Hana
H
Ghalim
Noreddine
N
Amrani
Souliman
S
D000818:Animals; D002784:Cholesterol / Q000097:blood; D029791:Ericaceae / Q000737:chemistry*; D005079:Excipients; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols; D059808:Polyphenols; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013634:Tannins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood; D014867:Water
D005079:Excipients; D005419:Flavonoids; D000960:Hypolipidemic Agents; D008055:Lipids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D044945:Proanthocyanidins; D013634:Tannins; D014280:Triglycerides; D014867:Water; D011092:Polyethylene Glycols; D002784:Cholesterol; D011345:Fenofibrate; C016811:tyloxapol