Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators.
A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.
Zhang
Xuqing
X
Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA. xzhang5@prdus.jnj.com
Li
Xiaojie
X
Allan
George F
GF
Sbriscia
Tifanie
T
Linton
Olivia
O
Lundeen
Scott G
SG
Sui
Zhihua
Z
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D008024:Ligands; D008297:Male; D008958:Models, Molecular; D018482:Muscle, Skeletal / Q000187:drug effects; D009919:Orchiectomy; D009929:Organ Size; D011467:Prostate / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013739:Testosterone / Q000378:metabolism
D007202:Indicators and Reagents; D008024:Ligands; D011720:Pyrazoles; D011944:Receptors, Androgen; C026262:imidazopyrazole; D013739:Testosterone