Study of KIR genes in tuberculosis patients.
A total of 97 patients with tuberculosis (TB) and 51 controls from Xalapa, Veracruz, Mexico, were studied for the presence and absence of killer cell immunoglobulin-like receptor (KIR) genes. The number of patients with either KIR2DL1 or KIR2DL3 differed significantly compared with the controls. However, only the difference in KIR2DL3 remained significant after correction for the number of factors analysed. We also found KIR2DS2 with its presumed C1 group ligand less prevalent in TB patients than in the control group, but this result lost significance after correction.
Méndez
A
A
Laboratory of Experiment Pathology, Faculty of Medicine, Universidad Veracruzana, México.
Granda
H
H
Meenagh
A
A
Contreras
S
S
Zavaleta
R
R
Mendoza
M F
MF
Izquierdo
L
L
Sarmiento
M E
ME
Acosta
A
A
Middleton
D
D
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D011971:Receptors, Immunologic / Q000145:classification / Q000235:genetics*; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics*
C515078:KIR2DL3 protein, human; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3