Achiral, cheap, and potent inhibitors of Plasmepsins I, II, and IV.
Boss
Christoph
C
Drug Discovery, Chemistry and Biology, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, 4123 Allschwil, Switzerland.
Corminboeuf
Olivier
O
Grisostomi
Corinna
C
Meyer
Solange
S
Jones
Andrew F
AF
Prade
Lars
L
Binkert
Christoph
C
Fischli
Walter
W
Weller
Thomas
T
Bur
Daniel
D
D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors*; D001665:Binding Sites; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000201:enzymology*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015800:Protozoan Proteins; D013329:Structure-Activity Relationship
D011480:Protease Inhibitors; D015800:Protozoan Proteins; D016282:Aspartic Acid Endopeptidases; C089643:plasmepsin; C100637:plasmepsin II