title: Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage.
abstract: Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity. Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of long-term health. I hypothesize that short-term survival was achieved by allocating scarce micronutrients by triage, in part through an adjustment of the binding affinity of proteins for required micronutrients. If this hypothesis is correct, micronutrient deficiencies that trigger the triage response would accelerate cancer, aging, and neural decay but would leave critical metabolic functions, such as ATP production, intact. Evidence that micronutrient malnutrition increases late onset diseases, such as cancer, is discussed. A multivitamin-mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life.
authors.affiliation: Nutrition and Metabolism Center, Children's Hospital of Oakland Research Institute, Oakland, CA 94609, USA. bames@chori.org
authors.forename: Bruce N
authors.initials: BN
authors.lastname: Ames
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence; D004249:DNA Damage; D004032:Diet; D019587:Dietary Supplements; D004194:Disease / Q000209:etiology*; D002149:Energy Intake; D006418:Heme / Q000378:metabolism; D006801:Humans; D044342:Malnutrition; D018977:Micronutrients / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000503:physiopathology; D018673:Nutrition Policy; D009751:Nutritional Requirements; D009752:Nutritional Status; D014131:Trace Elements
chemical_list: D018977:Micronutrients; D014131:Trace Elements; D006418:Heme