title: Direct C-H arylation of purines: development of methodology and its use in regioselective synthesis of 2,6,8-trisubstituted purines.
abstract: [Structure: see text] Direct C-H arylation of purines to position 8 by diverse aryl iodides was achieved with Pd catalysis in the presence of CuI and Cs2CO3. The methodology is general and efficient and was applied in the consecutive regioselective synthesis of 2,6,8-trisubstituted purines bearing three different C-substituents in combination with two cross-coupling reactions.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.
authors.forename: Igor
authors.initials: I
authors.lastname: Cerna
authors.forename: Radek
authors.initials: R
authors.lastname: Pohl
authors.forename: Blanka
authors.initials: B
authors.lastname: Klepetarová
authors.forename: Michal
authors.initials: M
authors.lastname: Hocek
mesh_terms: D008958:Models, Molecular; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis*
chemical_list: D011687:Purines