title: Mechanisms for recovery of motor function following cortical damage.
abstract: Recent studies of focal injury to the cerebral cortex have demonstrated that the remaining, intact tissue undergoes structural and functional changes that could play a substantial role in neurological recovery. New information regarding the molecular and cellular environment in the adjacent, intact tissue has suggested that waves of growth promotion and inhibition modulate the self-repair processes of the brain. Furthermore, recent studies have documented widespread neurophysiological and neuroanatomical changes in regions remote from a focal cortical injury, suggesting that entire cortical networks participate in the recovery process.
authors.affiliation: University of Kansas Medical Center, Landon Center on Aging, MS 1005 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. rnudo@kumc.edu
authors.forename: Randolph J
authors.initials: RJ
authors.lastname: Nudo
mesh_terms: D000818:Animals; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000503:physiopathology*; D020439:Growth Cones / Q000378:metabolism; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism; D009415:Nerve Net / Q000033:anatomy & histology / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D010291:Paresis / Q000209:etiology / Q000503:physiopathology*; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000503:physiopathology*
chemical_list: D009414:Nerve Growth Factors