title: MMP-2 and MMP-9 levels in peripheral blood after subarachnoid hemorrhage.
abstract: MMPs play an important role in ischemic and hemorrhagic stroke. We analyzed replicate serum samples from 20 normal healthy individuals to assess reproducibility of MMP determinations, and found that MMP-2 and MMP-9 determinations were quite consistent. We then studied the serum levels of MMP-2 and MMP-9 in patients suffering from subarachnoid hemorrhage (SAH), another stroke subtype. Serum MMP-2 and MMP-9 levels from SAH patients were measured sequentially using gelatine zymography in 11 patients after acute SAH. The occurrence of intracerebral aneurysms and vasospasms and the initial Hunt and Hess score were analysed in relation to MMP-levels. MMP-2 levels are significantly decreased while MMP-9 levels are increased in SAH patients relative to controls. MMP-2 levels remain depressed out to day 12 post SAH, but MMP-9 levels may recover by day 12.
authors.affiliation: Department of Neurology, Medical School, University of Heidelberg, Heidelberg, Germany.
authors.forename: Solveig
authors.initials: S
authors.lastname: Horstmann
authors.forename: Ying
authors.initials: Y
authors.lastname: Su
authors.forename: James
authors.initials: J
authors.lastname: Koziol
authors.forename: Uta
authors.initials: U
authors.lastname: Meyding-Lamadé
authors.forename: Simon
authors.initials: S
authors.lastname: Nagel
authors.forename: Simone
authors.initials: S
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D012016:Reference Values; D013345:Subarachnoid Hemorrhage / Q000097:blood*; D013997:Time Factors
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9