title: Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
abstract: We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.
authors.affiliation: Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
authors.forename: Norased
authors.initials: N
authors.lastname: Nasongkla
authors.forename: Erik
authors.initials: E
authors.lastname: Bey
authors.forename: Jimin
authors.initials: J
authors.lastname: Ren
authors.forename: Hua
authors.initials: H
authors.lastname: Ai
authors.forename: Chalermchai
authors.initials: C
authors.lastname: Khemtong
authors.forename: Jagadeesh Setti
authors.initials: JS
authors.lastname: Guthi
authors.forename: Shook-Fong
authors.initials: SF
authors.lastname: Chin
authors.forename: A Dean
authors.initials: AD
authors.lastname: Sherry
authors.forename: David A
authors.initials: DA
authors.lastname: Boothman
authors.forename: Jinming
authors.initials: J
authors.lastname: Gao
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000737:chemistry; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D039302:Integrin alphaVbeta3 / Q000737:chemistry; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D005290:Ferric Compounds; D039302:Integrin alphaVbeta3; D008024:Ligands; D008823:Micelles; D009842:Oligopeptides; D011108:Polymers; C000499:ferric oxide; C047981:arginyl-glycyl-aspartic acid; D004317:Doxorubicin