Human angiogenin lacks specific antimicrobial activity.
The antimicrobial activities of commercially available human angiogenin were studied against two pathogens, namely, Candida albicans and Streptococcus pneumoniae. In contrast to the data published earlier, antimicrobial action of angiogenin was rather limited and comparable to that of bovine serum albumin.
Avdeeva
Svetlana V
SV
Gamaleya Research Institute of Epidemiology and Microbiology, Gamaleya Street 18, 123098, Moscow, Russia.
Chernukha
M U
MU
Shaginyan
I A
IA
Tarantul
Viacheslav Z
VZ
Naroditsky
Boris S
BS
D000818:Animals; D000890:Anti-Infective Agents; D002176:Candida albicans / Q000187:drug effects*; D002417:Cattle; D006801:Humans; D008826:Microbial Sensitivity Tests; D012259:Ribonuclease, Pancreatic / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000890:Anti-Infective Agents; D012710:Serum Albumin, Bovine; C046366:angiogenin; D012259:Ribonuclease, Pancreatic