Synthesis of estradiol-pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells.
The synthesis, physico-chemical properties, cellular localization and photocytotoxicity of estradiol-pheophorbide a conjugates in estrogen-dependent cancer and vascular endothelial cells are described with the aim of increasing the photodynamic activity by targeting the nucleus of both tumor and blood vessel cells.
El-Akra
Naram
N
Laboratoire des Interactions Moléculaires et Réactivités Chimiques et Photochimiques, Université Paul Sabatier, 118 Rte de Narbonne, Toulouse Cedex 9, F-31062.
Noirot
Arielle
A
Faye
Jean-Charles
JC
Souchard
Jean-Pierre
JP
D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004249:DNA Damage; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D004958:Estradiol / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010778:Photochemotherapy; D017382:Reactive Oxygen Species; D013050:Spectrometry, Fluorescence; D013057:Spectrum Analysis / Q000379:methods
D017382:Reactive Oxygen Species; D002734:Chlorophyll; D004958:Estradiol; C032623:pheophorbide a