Cyclization reactions of homopropargyl azide derivatives catalyzed by PtCl4 in ethanol solution: synthesis of functionalized pyrrole derivatives.
[Structure: see text] PtCl4-catalyzed cyclization reactions of homopropargyl azide derivatives to pyrrole rings were investigated. Using ethanol as solvent with 2,6-di-tert-butyl-4-methylpyridine as the base was found to be the best set of conditions for effecting this ring-closing reaction. These reaction conditions can be applied to the preparation of functionalized pyrrole derivatives, with no effect on the functional groups.
Hiroya
Kou
K
Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai 980-8578, Japan. hiroya@mail.tains.tohoku.ac.jp
Matsumoto
Shigemitsu
S
Ashikawa
Masayasu
M
Ogiwara
Kentaro
K
Sakamoto
Takao
T
D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D000431:Ethanol / Q000737:chemistry*; D015394:Molecular Structure; D017671:Platinum Compounds / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
D001386:Azides; D017671:Platinum Compounds; D011758:Pyrroles; D000431:Ethanol; C032741:platinum tetrachloride