title: [Does hypertension need treatment following correction of coarctation in childhood?].
abstract: Does hypertension need treatment following correction of coarctation in childhood? The results of the surgical repair of aortic coarctation (CoA) are excellent. Prenatal diagnosis of this defect is made in 40% of the cases and this allowed a reduction of preoperative mortality. Beside these successes, patients who underwent a CoA repair in infancy remain at high risk for resting hypertension (HT) later in life. Indeed, half of the adolescents are hypertensive and 2/3 of the patients around 30 years. This HT is responsible for an increased mortality mostly related to cardiovascular events. Screening for HT and its risk factors is the main objective of the follow-up. Some residual anomalies such as recoarctation or hypoplasia of the horizontal aorta may be treated either by surgery or by interventional catheterisation. Recently, new contributors to hypertension have been identified such as abnormal geometry of the aortic arch or alteration of the mechanical properties of the arterial wall. In a given patient, the co-existence of vascular dysfunction and abnormal geometry of the aortic arch confers a high risk for HT. The indications to treat exercise HT or the type of antihypertensive drug to be given remain unsolved questions. Prevention may rely on substantial modifications of the surgical techniques to optimise the aortic arch geometry. The indications to correct abnormal geometries at high risk without recoarctation are not yet defined. The long-term benefit of either preventive or curative strategies might be difficult to evidence and will probably need the analysis of intermediate markers such as vascular function and left ventricular hypertrophy.
authors.affiliation: Cardiologie pédiatrique, Université Paris V-Descartes, Necker-Enfants Malades. INSERM EMIU0016, 149, rue de Sèvres 75743 Paris 15.
authors.forename: P
authors.initials: P
authors.lastname: Ou
authors.forename: E
authors.initials: E
authors.lastname: Mousseaux
authors.forename: I
authors.initials: I
authors.lastname: Szezepanski
authors.forename: Y
authors.initials: Y
authors.lastname: Aggoun
authors.forename: D
authors.initials: D
authors.lastname: Bonnet
mesh_terms: D001017:Aortic Coarctation / Q000150:complications / Q000601:surgery*; D002648:Child; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000628:therapy*; D012307:Risk Factors