The alveolar-epithelial barrier: a target for potential therapy.
During acute lung injury (ALI), the alveolar-capillary barrier is damaged, resulting in the accumulation of fluid and protein in the alveolar space characteristic of the acute respiratory distress syndrome (ARDS). Disordered epithelial repair may contribute to the development of fibrosis and worsen outcomes in patients who have lung injury. This article discusses novel emerging therapies based on these mechanisms that are designed to preserve the function and promote the repair of the alveolar epithelium in patients who have ALI/ARDS.
Budinger
G R Scott
GR
Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA.
Sznajder
Jacob I
JI
D000818:Animals; D015824:Blood-Air Barrier / Q000502:physiology*; D002199:Capillary Permeability / Q000502:physiology; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D011379:Prognosis; D012128:Respiratory Distress Syndrome / Q000378:metabolism* / Q000628:therapy*; D020545:Respiratory Mucosa / Q000378:metabolism; D015912:Thrombolytic Therapy / Q000379:methods*
D005343:Fibrinolytic Agents