Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production.
Glucuronoxylomannan (GXM) is the major capsular polysaccharide of Cryptococcus neoformans. GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.
Barbosa
Fabiane M
FM
Laboratório de Estudos Integrados em Bioquímica Microbiana, Departamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude (CCS), Rio de Janeiro, Brazil.
Fonseca
Fernanda L
FL
Figueiredo
Rodrigo T
RT
Bozza
Marcelo T
MT
Casadevall
Arturo
A
Nimrichter
Leonardo
L
Rodrigues
Marcio L
ML
D003455:Cryptococcus neoformans / Q000472:pathogenicity; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D011134:Polysaccharides / Q000494:pharmacology*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D011956:Receptors, Cell Surface / Q000502:physiology*
D016209:Interleukin-8; D018950:Lipopolysaccharide Receptors; D011134:Polysaccharides; D011956:Receptors, Cell Surface; C027478:glucuronoxylomannan