A mitotic role for BRCA1/BARD1 in tumor suppression?
The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.
Clarke
Paul R
PR
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK. p.r.clarke@dundee.ac.uk
Sanderson
Helen S
HS
D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D002457:Cell Extracts / Q000737:chemistry; D019281:Dimerization; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D009865:Oocytes / Q000737:chemistry; D010750:Phosphoproteins / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism*; D014404:Tubulin / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*; D014981:Xenopus / Q000378:metabolism; D029867:Xenopus Proteins / Q000378:metabolism; D020931:ran GTP-Binding Protein / Q000378:metabolism*
D019313:BRCA1 Protein; D018797:Cell Cycle Proteins; D002457:Cell Extracts; C000623051:Hmmr protein, Xenopus; D008869:Microtubule-Associated Proteins; C489079:NUMA1 protein, Xenopus; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; C486551:TPX2 protein, Xenopus; D014404:Tubulin; D025521:Tumor Suppressor Proteins; D029867:Xenopus Proteins; C102449:BARD1 protein, human; D044767:Ubiquitin-Protein Ligases; D020931:ran GTP-Binding Protein