title: The utility of computed tomography for recent-onset partial seizures in childhood.
abstract: OBJECTIVE
  To determine the diagnostic yield of computed tomography (CT) of the head in children presenting for the first time with partial seizures in a region with a high prevalence of tuberculosis and neurocysticercosis.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  The secondary-level ambulatory service of Red Cross Children's Hospital, Cape Town.
  
  
  METHODS
  Children aged 6 months-12 years with a first partial seizure. Outcome measures. Abnormal CT findings; clinically unsuspected abnormal CT findings.
  
  
  RESULTS
  Of 118 enrolled children, CT findings were available for 94 (80%). Sixteen (33%) of 49 children scheduled to return later for an initial CT scan failed to do so. Thirty-two scans (34%) were reported normal, 45 (48%) showed single or multiple granulomas, and 17 (18%) showed other findings. All 8 children with persistent specific CT findings were suspected of having the condition before CT scan. Of 68 cases with prospectively recorded clinically expected CT findings, normal scans were expected in 2 cases (3%) and occurred in 33 cases (49%).
  
  
  CONCLUSIONS
  Routine CT scan for children presenting with a first partial seizure in an area with a high prevalence of neurocysticercosis failed to identify findings other than neurocysticercosis that meaningfully altered clinical management. Assuming a 70% relative reduction of seizures with albendazole treatment for neurocysticercosis, routine CT scanning in the study population would require 11 scans and 5 courses of albendazole to prevent 1 child from having seizures, compared with no CT scans and 11 courses of albendazole with blanket use of albendazole.
authors.affiliation: School of Child and Adolescent Health, University of Cape Town, South Africa. swingler@ich.uct.ac.za
authors.forename: George H
authors.initials: GH
authors.lastname: Swingler
authors.forename: Anthony T R
authors.initials: AT
authors.lastname: Westwood
authors.forename: Karen
authors.initials: K
authors.lastname: Iloni
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*