Interaction studies of omeprazole with mefloquine, pyrimethamine and sulfadoxine.
Mefloquine hydrochloride, pyrimethamine and sulfadoxine as readily tolerated antimalarial drugs that are highly active against both usual and multidrug resistant strains of Plasmodium falciparum. Omeprazole reduce gastric acid secretion, irreversibly by inhibition of H+-K+ ATPase of the apical membrane of the parietal cell. In order to study the drug interactions of the later with antimalarials, in vitro availability of omeprazole has been studied in presence of mefloquine hydrochloride, pyrimethamine and sulfadoxine. The availability of antimalarial drugs was found to be influenced considerably in presence of omeprazole. The effect of dissolution mediums, simulating various body environments with respect to pH and the influence of temperature on these interactions has been examined in order to elucidate the mechanism of these interactions.
Arayne
M Saeed
MS
Department of Chemistry, University of Karachi, Karachi-75270, Pakistan. arayne@gawab.com
Sultana
Najma
N
Qureshi
M Shahid
MS
Naseem
Sajida
S
D000962:Antimalarials / Q000737:chemistry*; D004347:Drug Interactions; D006863:Hydrogen-Ion Concentration; D015767:Mefloquine / Q000737:chemistry*; D009853:Omeprazole / Q000494:pharmacology*; D011739:Pyrimethamine / Q000737:chemistry*; D012995:Solubility; D013413:Sulfadoxine / Q000737:chemistry*; D013816:Thermodynamics
D000962:Antimalarials; D013413:Sulfadoxine; D009853:Omeprazole; D015767:Mefloquine; D011739:Pyrimethamine